A specific category of drugs that prevent sleepiness by specifically targeting sleep-mechanisms in the brain. They are used to treat DISORDERS OF EXCESSIVE SOMNOLENCE such as NARCOLEPSY. Note that this drug category does not include broadly-acting central nervous system stimulants such as AMPHETAMINES.
A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.
Drugs that are used to treat RHEUMATOID ARTHRITIS.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Antibodies produced by a single clone of cells.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists.
Compounds that inhibit or block the activity of NEUROKININ-1 RECEPTORS.
Agents inhibiting the effect of narcotics on the central nervous system.
Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Drugs that bind to but do not activate GABA RECEPTORS, thereby blocking the actions of endogenous GAMMA-AMINOBUTYRIC ACID and GABA RECEPTOR AGONISTS.
A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric a7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Compounds that bind to and block the stimulation of PURINERGIC P1 RECEPTORS.
A family of hexahydropyridines.
A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.
Drugs that bind to and block the activation of ADRENERGIC ALPHA-2 RECEPTORS.
Infiltration of inflammatory cells into the parenchyma of PROSTATE. The subtypes are classified by their varied laboratory analysis, clinical presentation and response to treatment.
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
Pain in the pelvic region of genital and non-genital origin and of organic or psychogenic etiology. Frequent causes of pain are distension or contraction of hollow viscera, rapid stretching of the capsule of a solid organ, chemical irritation, tissue ischemia, and neuritis secondary to inflammatory, neoplastic, or fibrotic processes in adjacent organs. (Kase, Weingold & Gershenson: Principles and Practice of Clinical Gynecology, 2d ed, pp479-508)
A mixture of three different hydrogenated derivatives of ERGOTAMINE: DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and DIHYDROERGOCRYPTINE. Dihydroergotoxine has been proposed to be a neuroprotective agent and a nootropic agent. The mechanism of its therapeutic actions is not clear, but it can act as an alpha-adrenergic antagonist and a dopamine agonist. The methanesulfonate salts of this mixture of alkaloids are called ERGOLOID MESYLATES.
A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Agents that promote the excretion of urine through their effects on kidney function.
Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with nitrogen atoms.
A prolonged painful erection that may lasts hours and is not associated with sexual activity. It is seen in patients with SICKLE CELL ANEMIA, advanced malignancy, spinal trauma; and certain drug treatments.
An imprecise term which may refer to a sense of spatial disorientation, motion of the environment, or lightheadedness.
The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.
Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.
Discharge of URINE, liquid waste processed by the KIDNEY, from the body.
Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
A plant genus of the family POACEAE. The name is similar to Broom or Scotch Broom (CYTISUS) or Butcher's Broom (RUSCUS) or Desert Broom (BACCHARIS) or Spanish Broom (SPARTIUM).
A publication issued at stated, more or less regular, intervals.
The act or practice of literary composition, the occupation of writer, or producing or engaging in literary work as a profession.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.

alpha1-adrenergic receptor subtypes in human peripheral blood lymphocytes. (1/2042)

We investigated the expression of alpha1-adrenergic receptor subtypes in intact human peripheral blood lymphocytes using reverse transcription-polymerase chain reaction (RT-PCR) and radioligand binding assay techniques combined with antibodies against the three subtypes of alpha1-adrenergic receptors (alpha1A, alpha1B, and alpha1D). RT-PCR amplified in peripheral blood lymphocytes a 348-bp alpha1A-adrenergic receptor fragment, a 689-bp alpha1B-adrenergic receptor fragment, and a 540-bp alpha1D-adrenergic receptor fragment. Radioligand binding assay with [3H]prazosin as radioligand revealed a high-affinity binding with a dissociation constant value of 0. 65+/-0.05 nmol/L and a maximum density of binding sites of 175. 3+/-20.5 fmol/10(6) cells. The pharmacological profile of [3H]prazosin binding to human peripheral blood lymphocytes was consistent with the labeling of alpha1-adrenergic receptors. Antibodies against alpha1A-, alpha1B-, and alpha1D-receptor subtypes decreased [3H]prazosin binding to a different extent. This indicates that human peripheral blood lymphocytes express the three alpha1-adrenergic receptor subtypes. Of the three different alpha1-adrenergic receptor subtypes, the alpha1B is the most represented and the alpha1D, the least. Future studies should clarify the functional relevance of alpha1-adrenergic receptors expressed by peripheral blood lymphocytes. The identification of these sites may represent a step for evaluating whether they represent a marker of alpha1-adrenergic receptors in cardiovascular disorders or for assessing responses to drug treatment on these receptors.  (+info)

Modulation of basal intracellular calcium by inverse agonists and phorbol myristate acetate in rat-1 fibroblasts stably expressing alpha1d-adrenoceptors. (2/2042)

In rat-1 fibroblasts stably expressing alpha1d-adrenoceptors BMY 7378, phentolamine, chloroethylclonidine and 5-methyl urapidil decreased basal [Ca2+]i. WB 4101 induced a very small effect on this parameter but when added before the other antagonists it blocked their effect. All these agents inhibited the action of norepinephrine. Phorbol myristate acetate also blocked the effect of norepinephrine and decreased basal [Ca2+]i. Staurosporine inhibited these effects of the phorbol ester. Our results suggest that: (1) alpha1d-adrenoceptors exhibit spontaneous ligand-independent activity, (2) BMY 7378, phentolamine, chloroethylclonidine and 5-methyl urapidil act as inverse agonists and (3) protein kinase C activation blocks spontaneous and agonist-stimulated alpha1d-adrenoceptor activity.  (+info)

Transcriptional regulation of alpha1-adrenoceptor gene in the rat liver during different phases of sepsis. (3/2042)

Changes in alpha1-adrenoceptor (alpha1AR) gene expression in the rat liver during different phases of sepsis were studied. Sepsis was induced by cecal ligation and puncture (CLP). Septic rats exhibit two metabolically distinct phases: an initial hyperglycemic phase (9 h after CLP, early sepsis) followed by a hypoglycemic phase (18 h after CLP; late sepsis). The [3H]prazosin binding studies show that the density of alpha1AR was increased by 30% during the early phase while it was decreased by 24% during the late phase of sepsis. Western blot analyses reveal that alpha1AR protein level was elevated by 48% during early sepsis but was decreased by 55% during late sepsis. Northern blot analyses depict that the steady-state level of alpha1bAR mRNA was enhanced by 21% during the early phase but was declined by 29% during the late phase of sepsis. Nuclear run-off assays show that the transcription rate of alpha1bAR gene transcript was increased by 76% during early sepsis while it was decreased by 29% during late sepsis. The actinomycin D pulse-chase studies indicate that the half-life of alpha1bAR mRNA remained unaffected during the early and the late phases of sepsis. These findings demonstrate that during the early phase of sepsis, the increase in the rate of transcription of alpha1bAR gene paralleled with the elevations in the alpha1bAR mRNA abundance and alpha1AR protein level, while during the late phase of sepsis, the decrease in the rate of transcription of alpha1bAR gene coincided with the declines in the alpha1bAR mRNA abundance and the alpha1AR protein level in the rat liver. These observations indicate that the altered expression of alpha1AR genes in the rat liver during the progression of sepsis was regulated transcriptionally.  (+info)

Facilitation and depression of ATP and noradrenaline release from sympathetic nerves of rat tail artery. (4/2042)

1. Excitatory junction currents (EJCs) were used to measure ATP release; noradrenaline (NA) oxidation currents and fractional overflow of labelled NA, [3H]NA, were used to monitor the release of endogenous and exogenous NA, respectively, from post-ganglionic sympathetic nerves of rat tail artery. 2. During nerve stimulation with 100 pulses at 5-20 Hz the EJCs initially grew in size (maximally by 23 %, at 2-10 Hz), and then depressed, maximally by 68 % at 20 Hz. 3. The peak amplitude of NA oxidation currents in response to nerve stimulation with 100 pulses at 2-20 Hz grew in size with frequency, while the area was independent of frequency and roughly constant. 4. The size of the NA oxidation currents evoked by nerve stimulation with 4-100 pulses at 20 Hz grew linearly with train length between pulses 4-16. Between pulses 20-100 there was a train length-dependent depression of the signal. 5. Fractional overflow of [3H]NA in response to nerve stimulation with 5-100 pulses at 20 Hz behaved similarly to the EJCs. It initially grew roughly linearly between pulses 5-25, and then showed a dramatic depression similar to that of the EJCs. 6. The alpha2-adrenoceptor antagonists rauwolscine and yohimbine increased the overflow of [3H]NA and the amplitude of NA oxidation currents, but not that of the EJCs. 7. It is concluded that during high-frequency stimulation (i) the release of ATP and NA is first briefly facilitated then markedly depressed, (ii) facilitation and depression of the two transmitters are similar in magnitude and time course, and (iii) alpha2-adrenoceptor antagonists differentially modify EJCs and the NA signals. The results obtained in the absence of drugs are compatible with the hypothesis that ATP and NA are released in parallel, while the effects of alpha2-adrenoceptor antagonists seem to suggest dissociated release.  (+info)

Homologous regulation of the alpha2C-adrenoceptor subtype in human hepatocarcinoma, HepG2. (5/2042)

1. Previous studies of the regulation of the alpha2C-adrenoceptor in OK and in transfected cells have led to discrepant conclusions. In the present work, we examined the homologous regulation of the human alpha2C-adrenoceptor in the hepatocarcinoma cell-line, HepG2; a model which expresses this subtype spontaneously. 2. Short-period treatment of the cells with UK14304 provoked neither a diminution of the potency of the alpha2-agonist to inhibit forskolin-induced cyclic AMP-accumulation nor a change in the degree of receptor coupling to G-proteins. 3. Long-period exposure to UK14304 resulted in a large reduction of [3H]MK912 binding sites (55% decrease). The action of UK14304 was dose-dependent (EC50 = 190 +/- 45 nM), rapid (t1/2 = 4.2 h) and reversible. Receptor down-regulation was also observed with clonidine or (-)adrenaline (38 and 36% decrease, respectively) and was blocked by the addition of alpha2-antagonists. 4. Conversely to that observed with alpha2-agonists, treatment of the cells with RX821002 or yohimbine alone, but not with phentolamine, promoted a significant increase of the receptor expression. 5. The observed alterations of receptor density are not the reflection of changes at the alpha2C4 mRNA level. Estimation of the receptor protein turnover and measurement of its half-life demonstrated that down-regulation by alpha2-agonists and up-regulation by alpha2-antagonists, with inverse-agonist efficacy, are respectively the consequence of increased and decreased rate of receptor degradation. 6. In conclusion, our data show that alpha2C-adrenoceptor does not undergo desensitization but is down-regulated in HepG2. The lack of desensitization agrees with previous results obtained in cells transfected with the alpha2C4 gene, but not with observations made in OK cells. Inversely, down-regulation fits with results obtained in OK but not in transfected cells. The reasons for these discrepancies are discussed. Our results also demonstrated that certain alpha2-antagonists behave as inverse agonist on the HepG2 model and thus provide for the first time evidence of inverse efficacy of antagonists on a cellular model expressing physiological level of a wild-type alpha2-adrenoceptor.  (+info)

Effects of heptanol on the neurogenic and myogenic contractions of the guinea-pig vas deferens. (6/2042)

1. The effects of the putative gap junction uncoupler, 1-heptanol, on the neurogenic and myogenic contractile responses of guinea-pig vas deferens were studied in vitro. 2. Superfusion of 2.0 mM heptanol for 20-30 min produced the following reversible changes in the biphasic neurogenic contractile response (8 trials): (i) suppression of both phases; (ii) delayed development of both the first as well as the second phase, accompanied by complete temporal separation of the two phases; (iii) prominent oscillations of force during the second (noradrenergic) phase only. 3. To eliminate prejunctional effects of heptanol, myogenic contractions were evoked by field stimulation of the vas in the presence of suramin (200 microM) and prazosin (1 microM). Heptanol (2.0 mM) abolished these contractions reversibly. 4. These results show that (i) heptanol inhibits both excitatory junction potential (EJP)-dependent and non EJP-dependent contractions of the vas; (ii) a postjunctional site of action of heptanol, probably intercellular uncoupling of smooth muscle cells, contributes to the inhibition of contraction.  (+info)

Nitric oxide mediates sympathetic vasoconstriction at supraspinal, spinal, and synaptic levels. (7/2042)

The purposes of this study were to investigate the level of the sympathetic nervous system in which nitric oxide (NO) mediates regional sympathetic vasoconstriction and to determine whether neural mechanisms are involved in vasoconstriction after NO inhibition. Ganglionic blockade (hexamethonium), alpha1-receptor blockade (prazosin), and spinal section at T1 were used to study sympathetic involvement. NO was blocked with Nomega-nitro-L-arginine methyl ester (L-NAME). Regional blood flow in the mesenteric and renal arteries and terminal aorta was monitored by electromagnetic flowmetry in conscious rats. L-NAME (3-5 mg/kg iv) increased arterial pressure and peripheral resistance. Ganglionic blockade (25 mg/kg iv) significantly reduced the increase in resistance in the mesentery and kidney in intact and spinal-sectioned rats. Ganglionic blockade significantly decreased hindquarter resistance in intact rats but not in spinal-sectioned rats. Prazosin (200 micrograms/kg iv) significantly reduced the increased hindquarter resistance. We concluded that NO suppresses sympathetic vasoconstriction in the mesentery and kidney at the spinal level, whereas hindquarter tone is mediated at supraspinal and synaptic levels.  (+info)

Facilitatory beta2-adrenoceptors on cholinergic and adrenergic nerve endings of the guinea pig trachea. (8/2042)

Using electrical field stimulation of epithelium-denuded intact guinea pig tracheal tube preparations, we studied the presence and role of prejunctional beta2-adrenoceptors by measuring evoked endogenous acetylcholine (ACh) and norepinephrine (NE) release directly. Analysis of ACh and NE was through two HPLC systems with electrochemical detection. Electrical field stimulation (150 mA, 0.8 ms, 16 Hz, 5 min, biphasic pulses) released 29.1 +/- 2.5 pmol ACh/g tissue and 70.2 +/- 6.2 pmol NE/g tissue. Preincubation for 15 min with the selective beta2-adrenoceptor agonist fenoterol (1 microM) increased both ACh and NE overflow to 178 +/- 28 (P < 0.01) and 165 +/- 12% (P < 0.01), respectively, of control values, increases that were abolished completely by the selective beta2-adrenoceptor antagonist ICI-118551 (1 microM). Further experiments with increasing fenoterol concentrations (0.1-100 microM) and different preincubation periods (1, 5, and 15 min) showed a strong and concentration-dependent facilitation of NE release, with maximum response levels decreasing (from nearly 5-fold to only 2.5-fold of control value) with increasing agonist contact time. In contrast, sensitivity of facilitatory beta2-adrenoceptors on cholinergic nerves to fenoterol gradually increased when the incubation period was prolonged; in addition, a bell-shaped concentration-response relationship was found at 15 min of preincubation. Fenoterol concentration-response relationships (15-min agonist preincubation) in the presence of atropine and yohimbine (1 microM each) were similar in the case of NE release, but in the case of ACh release, the bell shape was lost. The results indicate a differential capacity and response time profile of facilitatory prejunctional beta2-adrenoceptors on adrenergic and cholinergic nerve terminals in the guinea pig trachea and suggest that the receptors on adrenergic nerves are more susceptible to desensitization.  (+info)

Synonyms for alpha-blocking agent in Free Thesaurus. Antonyms for alpha-blocking agent. 2 synonyms for alpha: first and last, be-all and end-all. What are synonyms for alpha-blocking agent?
Alpha blockers lower blood pressure by keeping the hormone norepinephrine from tightening the muscles in the walls of smaller arteries and veins. As a result, the vessels remain open and relaxed. This improves blood flow and lowers blood pressure.. Because alpha blockers also relax other muscles throughout the body, these medications also can help improve urine flow in older men with prostate problems.. Alpha blockers are either short-acting or long-acting. Short-acting medications work quickly, but their effects last only a few hours. Long-acting medications take longer to work, but their effects last longer. The alpha blocker thats best for you depends on your health and the condition being treated.. Alpha blockers are also called alpha-adrenergic blocking agents, alpha-adrenergic antagonists, adrenergic blocking agents and alpha-blocking agents.. Examples of alpha blockers used to treat high blood pressure include:. ...
Several important results were obtained from the present studies. First, in accordance with many previous reports, PCP was found repeatedly to disrupt PPI (Bakshi and Geyer, 1995; Bakshi et al., 1994; Mansbach and Geyer, 1989; Swerdlow et al., 1996; Wiley, 1994; Varty and Higgins, 1994; Johansson et al., 1994b). Second, the selective alpha-1 noradrenergic antagonist prazosin prevented the PCP-induced deficit in PPI. This effect was produced by multiple prazosin doses, was observed over multiple prepulse intensities and was replicated in a second separate experiment. Finally, selective antagonists for eitheralpha-2 (RX821002), muscarinic M1 (pirenzepine) or GABA-A (pitrazepin) receptors had no effect on the disruption of PPI produced by PCP. Taken together, these results indicate strongly that the impairment of sensorimotor gating induced by PCP involves the presumably indirect activation of alpha-1 adrenergic receptors, but probably not alpha-2, M1 or GABA-A receptors.. To the best of our ...
Define alpha-blocker. alpha-blocker synonyms, alpha-blocker pronunciation, alpha-blocker translation, English dictionary definition of alpha-blocker. n. A drug that blocks or counteracts the effects of epinephrine and other molecules that stimulate alpha-receptors, leading to various physiological...
Alpha-blockers, also known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors). Historically, alpha-blockers were used as a tool for pharmacologic research to develop a greater understanding of the autonomic nervous system. Using alpha blockers, scientists began characterizing arterial blood pressure and central vasomotor control in the autonomic nervous system. Today, they can be used as clinical treatments for a limited number of diseases. Although alpha blockers can only treat a small range of diseases, some of them have clinical uses, such as having the ability to treat hypertension, Raynauds disease, Congestive Heart Failure, erectile dysfunction, etc. Generally speaking, all of these treatments function by binding an α-blocker to α receptors in the arteries and smooth muscle. Ultimately, this relaxes the smooth muscle or blood vessels, which increases fluid flow in these entities. ...
Ioannides, C, Okine, L and Parke, DV (1979) Effects of β-adrenoceptor antagonists on the hepatic mixed-function oxygenases in the rat ...
BACKGROUND AND PURPOSE: In mouse tail arteries, selective alpha(2)-adrenoceptor antagonism with rauwolscine caused powerful dilation during constriction to the alpha(1)-adrenoceptor agonist phenylephrine. This study therefore assessed phenylephrines selectivity at vascular alpha-adrenoceptors and the mechanism(s) underlying dilation to rauwolscine. EXPERIMENTAL APPROACH: Mouse isolated tail arter
Prazosin: Belongs to the class of alpha-adrenoreceptor antagonists, peripherally-acting antiadrenergic agents. Used in the treatment of hypertension.,
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TY - JOUR. T1 - Rationale for the inclusion of alpha-adrenergic blockade in benign prostatic hyperplasia treatment guidelines. AU - Roehrborn, Claus. PY - 1996/1/1. Y1 - 1996/1/1. N2 - The effectiveness and safety of a-adrenergic blockade for the treatment of BPH has been demonstrated in large-scale, randomized, placebo-controlled, multicenter trials. Good patient compliance, low failure or retreatment rates, and cost-effectiveness have also been shown. Moreover, therapeutic success has been independent of the healthcare provider or venue. Accordingly, both the Agency for Health Care Policy and Research (AHCPR) and the 3rd International Consultation on BPH have recognized α1-specific adrenergic receptor blockers as a reasonable treatment alternative for men with symptomatic BPH.. AB - The effectiveness and safety of a-adrenergic blockade for the treatment of BPH has been demonstrated in large-scale, randomized, placebo-controlled, multicenter trials. Good patient compliance, low failure or ...
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Several important results were obtained from the present studies. First, in accordance with many previous reports, PCP was found repeatedly to disrupt PPI (Bakshi and Geyer, 1995; Bakshi et al., 1994; Mansbach and Geyer, 1989; Swerdlow et al., 1996; Wiley, 1994; Varty and Higgins, 1994; Johansson et al., 1994b). Second, the selective alpha-1 noradrenergic antagonist prazosin prevented the PCP-induced deficit in PPI. This effect was produced by multiple prazosin doses, was observed over multiple prepulse intensities and was replicated in a second separate experiment. Finally, selective antagonists for eitheralpha-2 (RX821002), muscarinic M1 (pirenzepine) or GABA-A (pitrazepin) receptors had no effect on the disruption of PPI produced by PCP. Taken together, these results indicate strongly that the impairment of sensorimotor gating induced by PCP involves the presumably indirect activation of alpha-1 adrenergic receptors, but probably not alpha-2, M1 or GABA-A receptors.. To the best of our ...
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Hytrin is an alpha-adrenergic blocker, which relaxes blood vessels. It is prescribed to treat hypertension and benign prostatic hyperplasia.
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This review evaluates the role of α-adrenoceptor antagonists as a potential treatment of prostate cancer (PCa). Cochrane, Google Scholar and Pubmed were accessed to retrieve sixty-two articles for analysis. In vitro studies demonstrate that doxazosin, prazosin and terazosin (quinazoline α-antagonists) induce apoptosis, decrease cell growth, and proliferation in PC-3, LNCaP and DU-145 cell lines. Similarly, the piperazine based naftopidil induced cell cycle arrest and death in LNCaP-E9 cell lines. In contrast, sulphonamide based tamsulosin did not exhibit these effects. In vivo data was consistent with in vitro findings as the quinazoline based α-antagonists prevented angiogenesis and decreased tumour mass in mice models of PCa. Mechanistically the cytotoxic and antitumor effects of the α-antagonists appear largely independent of α 1-blockade. The proposed targets include: VEGF, EGFR, HER2/Neu, caspase 8/3, topoisomerase 1 and other mitochondrial apoptotic inducing factors. These cytotoxic effects
This review evaluates the role of α-adrenoceptor antagonists as a potential treatment of prostate cancer (PCa). Cochrane, Google Scholar and Pubmed were accessed to retrieve sixty-two articles for analysis. In vitro studies demonstrate that doxazosin, prazosin and terazosin (quinazoline α-antagonists) induce apoptosis, decrease cell growth, and proliferation in PC-3, LNCaP and DU-145 cell lines. Similarly, the piperazine based naftopidil induced cell cycle arrest and death in LNCaP-E9 cell lines. In contrast, sulphonamide based tamsulosin did not exhibit these effects. In vivo data was consistent with in vitro findings as the quinazoline based α-antagonists prevented angiogenesis and decreased tumour mass in mice models of PCa. Mechanistically the cytotoxic and antitumor effects of the α-antagonists appear largely independent of α 1-blockade. The proposed targets include: VEGF, EGFR, HER2/Neu, caspase 8/3, topoisomerase 1 and other mitochondrial apoptotic inducing factors. These cytotoxic effects
Flomax is a drug that is often used to treat benign prostatic hyperplasia (BPH). It is an alpha-blocker and it affects the hormones adrenaline and noradrenaline. There may be side effects, and other drugs may be used. Home remedies can also help relieve symptoms. Find out more about Flomax and other treatment options.
The exact mechanism of the hypotensive action of prazosin is unknown. Prazosin causes a decrease in total peripheral resistance and was originally thought to have a direct relaxant action on vascular smooth muscle. Recent animal studies, however, have suggested that the vasodilator effect of prazosin is also related to blockade of postsynaptic alpha-adrenoceptors. The results of dog forelimb experiments demonstrate that the peripheral vasodilator effect of prazosin is confined mainly to the level of the resistance vessels (arterioles). Unlike conventional alpha-blockers, the antihypertensive action of prazosin is usually not accompanied by a reflex tachycardia. Tolerance has not been observed to develop in long term therapy.. Hemodynamic studies have been carried out in man following acute single dose administration and during the course of long term maintenance therapy. The results confirm that the therapeutic effect is a fall in blood pressure unaccompanied by a clinically significant change ...
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Hytrin is an alpha-adrenergic blocker, which relaxes blood vessels. It is prescribed to treat hypertension and benign prostatic hyperplasia.
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Doxazosin is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. Doxazosin relaxes your veins and arteries so that blood can more easily pass through them. It also relaxes the muscles in the prostate and bladder neck, making it easier to urinate. Doxazosin is used to treat hypertension (high blood pressure), or to...
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Antiadrenergic agents inhibit the activity of the sympathetic nervous system. They act by blocking adrenergic receptors in target organs or by inhibiting the s…
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Alpha-2 adrenergic antagonist Increase blood pressure Yohimbine[111] Prognosis[edit]. POTS has a favorable prognosis when ... Alpha-1 adrenergic receptor agonist Constrict the peripheral blood vessels aiding venous return. Midodrine[17][89][90][91] ... alpha-2 adrenergic receptor agonist Decreases blood pressure and sympathetic nerve traffic. Clonidine,[12] Methyldopa[12] ... Antibodies against the Alpha 1 adrenergic receptor and muscarinic acetylcholine M4 receptor[4][5][6]. ...
... is an antihypertensive alpha-adrenergic antagonist. Trcka, V; König, J; Mácová, S; Smíd, M; Helfert, I; Votavová, M; ... a novel alpha-adrenergic antagonist". Biopharmaceutics & Drug Disposition. 10 (6): 581-9. doi:10.1002/bdd.2510100607. PMID ...
... is an alpha-1 adrenergic antagonist. Terazosin Chiang, J; Hermodsson, G; Oie, S (1991). "The effect of alpha 1-acid ... glycoprotein on the pharmacological activity of alpha 1-adrenergic antagonists in rabbit aortic strips". The Journal of ...
Prazosin, an alpha-1 adrenergic antagonist, has been used in veterans with PTSD to reduce nightmares. Studies show variability ... adrenergic inhibitors, antipsychotics, and even anticonvulsants), benzodiazepines should be considered relatively ...
... a specific antagonist radioligand for brain alpha 2-adrenergic receptors". European Journal of Pharmacology. 76 (4): 461-4. doi ... Rauwolscine acts predominantly as a α2-adrenergic receptor antagonist. It has also been shown to function as a 5-HT1A receptor ... Wainscott DB, Sasso DA, Kursar JD, Baez M, Lucaites VL, Nelson DL (January 1998). "[3H]Rauwolscine: an antagonist radioligand ... Perry BD, U'Prichard DC (December 1981). "[3H]rauwolscine (alpha-yohimbine): ...
Earl CQ, Prozialeck WC, Weiss B.: Interaction of alpha adrenergic antagonists with calmodulin. Life Sci. 1984 Jul 30;35(5):525- ... alpha adrenergic antagonists [23]and phenothiazineantipsychotic drugs were potent inhibitors of calmodulin activated enzymes [ ... in that older animals evidence a decrease in beta-adrenergic receptors and a reduced response to adrenergic stimuli [34,35,36 ... Greenberg, L.H. and Weiss, B.: Beta adrenergic receptors in aged rat brain: reduced number and capacity of pineal gland to ...
Systemic Alpha-1 adrenergic receptor antagonists have been implicated in Intraoperative Floppy Iris Syndrome (IFIS). Bunazosin ... Bunazosin (INN) is an alpha 1 antagonist. Bunazosin was initially developed to treat benign prostatic hyperplasia (BPH). It has ...
Conversely, coadministration of NMDA-antagonists with alpha-2 adrenergic antagonists, like yohimbine, could theoretically ... Drugs that work to suppress NAN include anticholinergics, benzodiazepines, barbiturates and Alpha-adrenergic agonists, such as ... D.Wozniak - NMDA Antagonist Neurotoxicity: Mechanism and Prevention] Olney J, Labruyere J, Wang G, Wozniak D, Price M, Sesma M ... Firstly, NMDA receptor antagonist are physician-prescribed drugs for therapeutic treatment of human diseases such as memantine ...
... is an alpha-2 adrenergic antagonist, and has been used in a variety of research projects. It is a veterinary drug ... February 2000). "Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, ... It behaves as an antagonist at α1-adrenergic, α2-adrenergic, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, and dopamine D2, and as a partial ... Saenz de Tejada I, Kim NN, Goldstein I, Traish AM (March 2000). "Regulation of pre-synaptic alpha adrenergic activity in the ...
"Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists". ... It acts as an α2-adrenergic receptor antagonist similarly to other imidazoles like idazoxan. It was never marketed. ... Fenmetozole (DH-524) is a drug which was patented as an antidepressant, but was later studied as an antagonist of the effects ...
Yang G, Wei Q, Li H, Yang Y, Zhang S, Dong Q; Wei; Li; Yang; Zhang; Dong (2006). "The effect of alpha-adrenergic antagonists in ... Alpha blockers and/or antibiotics appear to be the most effective with NSAIDs such as ibuprofen providing lesser benefit. ... The effectiveness of alpha blockers (tamsulosin, alfuzosin) is questionable in men with CPPS. A 2006 meta-analysis found that ... He, L.; Wang, Y.; Long, Z.; Jiang, C. (Dec 2009). "Clinical Significance of IL-2, IL-10, and TNF-alpha in Prostatic Secretion ...
Labetalol (koristi se za hipertenziju; it is a mixed alpha/beta adrenergic antagonist)[4] ... Elliott J (1997). „Alpha-adrenoceptors in equine digital veins: evidence for the presence of both α1 and α2-receptors mediating ... Fentolamin (koristi se za hipertenzivne hitne slučajeve; to je neselektivni alfa-antagonist) ...
... relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists". Journal ... It acts as a centrally-acting α1 and α2 adrenergic receptor antagonist (with IC50 4.85 μM and 0.0091 μM, respectively). In ... Roden DM, Nadeau JH, Primm RK (June 1988). "Electrophysiologic and hemodynamic effects of chronic oral therapy with the alpha 2 ...
Yang G, Wei Q, Li H, Yang Y, Zhang S, Dong Q (2006). "The effect of alpha-adrenergic antagonists in chronic prostatitis/chronic ...
... a specific antagonist radioligand for brain alpha 2-adrenergic receptors". European Journal of Pharmacology. 76 (4): 461-4. ... Rauvolscin deluje predominantno kao antagonist α2-adrenergičnog receptora.[2] On takođe deluje kao parcijalni agonist 5-HT1A ... Wainscott DB, Sasso DA, Kursar JD, Baez M, Lucaites VL, Nelson DL (1998). „[3H]Rauwolscine: an antagonist radioligand for the ... Perry BD, U'Prichard DC (1981). „[3H]rauwolscine (alpha-yohimbine): ...
... related to ketanserin such as ritanserin are more selective 5-HT2A receptor antagonists with low affinity for alpha-adrenergic ... Other antagonists are MDL-100,907 (prototype of another new series of 5-HT2A antagonists) and cyproheptadine. Pizotifen is a ... Trazodone is a potent 5-HT2A antagonist, as well as an antagonist on other serotonin receptors. Mirtazapine is a 5-HT2A, 5-HT2C ... However, there is at least one antagonist at this site which has been shown to up-regulate 5-HT2A receptors. Additionally, a ...
They are primarily postsynaptic adrenergic receptor antagonists (alpha and beta adrenergic receptor antagonists, or "blockers ... Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. Raskind and colleagues studied the ... ICI-118,551 Highly selective β2-adrenergic receptor antagonist - No known clinical applications, but used in experiments due to ... α1 antagonist) Doxazosin (alpha blocker) Beta blockers Non-selective agents Alprenolol Bucindolol Carteolol Carvedilol (has ...
... is a drug which acts as a potent and selective antagonist for the Alpha-1 adrenergic receptor subtype α1B. It has ... Yang XP, Chiba S (August 2002). "Effects of L-765,314, a selective and potent alpha 1B-adrenoceptor antagonist, on periarterial ... a potent and selective alpha1b adrenergic receptor antagonist ". Journal of Medicinal Chemistry. 41 (8): 1205-8. doi:10.1021/ ... alpha(1D)-, and alpha(2)-adrenoceptors". European Journal of Pharmacology. 613 (1-3): 86-92. doi:10.1016/j.ejphar.2009.04.011. ...
In addition, it has alpha-adrenergic antagonist activities in vascular tissue, and it has also been reported to have ...
... is an α1-adrenergic receptor antagonist. Alpha blocker Tham TC, Guy S, Shanks RG, Harron DW (April 1992). "Dose-dependent alpha ... 1-adrenoceptor antagonist activity of the anti-arrhythmic drug, abanoquil (UK-52,046), without reduction in blood pressure in ...
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... alpha-adrenergic agonist, alpha 1 antagonists). Urinary symptoms may include frequency, urgency, incontinence or recurrent ... Alpha blockers can also reduce outlet resistance and allow complete emptying if there is adequate bladder muscle function. ...
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... related to ketanserin such as ritanserin are more selective 5-HT2A receptor antagonists with low affinity for alpha-adrenergic ... Silent antagonistsEdit. *Trazodone is a potent 5-HT2A antagonist, as well as an antagonist on other serotonin receptors. ... Other antagonists are MDL-100,907 (prototype of another new series of 5-HT2A antagonists) and cyproheptadine. ... but through its high affinity for alpha1 adrenergic receptors. It also has high affinity for H1 histaminergic receptors equal ...
5-Alpha-reductase inhibitor Angiotensin II receptor antagonist ACE inhibitor Alpha-adrenergic agonist Beta blocker Dopamine ... For receptors, these activities include agonist, antagonist, inverse agonist, or modulator. Enzyme target mechanisms include ... agonist Dopamine antagonist Incretin mimetic Nonsteroidal anti-inflammatory drug − cyclooxygenase inhibitor Proton-pump ...
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... an alpha-2 adrenergic agonist Irbesartan, an angiotensin II receptor antagonist Propranolol, a sympatholytic beta blocker ... Such medications include antipsychotics, antidepressants, anticonvulsants, alpha agonists and anticholinergics. It should also ... Vasopressin receptor antagonists, such as conivaptan Acetazolamide, a carbonic anhydrase inhibitor Lithium was previously used ...
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... by drugs known as neurokinin type 1 antagonists (also termed: SP antagonists, or tachykinin antagonists.) One such drug is ... Azzolina A, Bongiovanni A, Lampiasi N (Dec 2003). "Substance P induces TNF-alpha and IL-6 production through NF kappa B in ... administered through the non-adrenergic, non-cholinergic nervous system (branch of the vagal system). ... Muñoz M, Rosso M, Coveñas R (2010). "A new frontier in the treatment of cancer: NK-1 receptor antagonists". Current Medicinal ...
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腎上腺素受體激動藥 (α(英語:Alpha-adrenergic agonist) ... Glutamate receptor antagonist(英語:Excitatory amino acid antagonist) (NMDA(英語:NMDA receptor antagonist)) ... Cannabinoid receptor antagonist(英語:Cannabinoid receptor antagonist). *Endocannabinoid enhancer(英語:Endocannabinoid enhancer) ( ... 腎上腺素受體拮抗劑 (α(英語:Alpha blocker) (1
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SoRI-20040; Antagonist-like: SoRI-20041. *Adrenergic release blockers: Bethanidine. *Bretylium. *Guanadrel ... N,alpha-Diethylphenylethylamine. *N-Ethylbuphedrone. *N-Ethylhexedrone. *N,N-Dimethylphenethylamine. *Naphthylamphetamine. * ...
alpha-Ergosine *IUPAC name: Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(2-methylpropyl)-, (5'-alpha)- ... a 5-HT1A agonist/5-HT2A antagonist, and mesulergine, a 5-HT2A/2C antagonist.[15] The selectivity and affinity of ergolines for ... The antagonist or agonist behavior of the ergolines are substrate dependent and mixed agonist/antagonist behaviors of ergoline ... alpha-Ergocryptine. CH(CH3)2. CH2CH(CH3)2. Leucine ... Adrenergic receptor modulators. α1. *Agonists: 6-FNE. * ...
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Meta-[I-131]iodobenzylguanidine is a radio-labeled analog of the adrenergic blocking agent guanethidine.[37] Radioactivity is ... alpha emitters. *223Ra (Radium chloride). beta emitters. *32P. *89Sr ...
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SoRI-20040; Antagonist-like: SoRI-20041. *Adrenergic release blockers: Bethanidine. *Bretylium. *Guanadrel ... 2,5-DMA is the alpha-methyl homologue of 2C-H and could be called "DOH" under the DO naming scheme. ...
Adrenergic stimulants, such as ephedrine, may act by directly binding and activating the receptors that norepinephrine and ... but other drugs such as CB1 receptor antagonists exist in this class too.[25][26] Drugs used to treat sleep disorders such as ... on adrenergic receptors.[83] It is most usually marketed as the hydrochloride or sulfate salt. ... but inhaled adrenergic drugs are now preferred due to less systemic side effects. Pseudoephedrine is used to relieve nasal or ...
Guanfacine - Sympatholytic, α2-adrenergic receptor agonist.. *Prazosin - Sympatholytic, alpha blocker.. Comorbidity[edit]. GAD ... Hydroxyzine - Antihistamine, 5-HT2A receptor antagonist.. *Propranolol - Sympatholytic, beta blocker.. *Clonidine - ...
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Alpha-1 blockers (e.g., prazosin). *Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) ... Serotonin antagonists and reuptake inhibitors *Etoperidone. *Nefazodone. *Trazodone. *Tricyclic antidepressants *Amitriptyline ...
α1(英语:Alpha-1 adrenergic receptor) (A, B, D) · α2(英语:Alpha-2 adrenergic receptor) (A, B, C) · β1 · β2 · β3 ... GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor. British Journal of Pharmacology. January 1994 ...
However, β2 adrenergic receptor agonists are not recommended to treat ARDS because it may reduce survival rates and precipitate ... Recombinant activated protein C (drotrecogin alpha) was originally introduced for severe sepsis (as identified by a high APACHE ... and H2 antagonist are useful in a person with risk factors of developing upper gastrointestinal bleeding (UGIB) such as on ...
SoRI-20040; Antagonist-like: SoRI-20041. *Adrenergic release blockers: Bethanidine. *Bretylium. *Guanadrel ... Antagonists: AR-A000002. *Beta blockers (e.g., alprenolol, carteolol, isamoltane, oxprenolol, penbutolol, propranolol, ... Antagonists: ABT-354. *Atypical antipsychotics (e.g., aripiprazole, asenapine, clorotepine, clozapine, fluperlapine, ... Antagonists: Agomelatine. *Atypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, cariprazine, ...
It is an alpha-2 adrenergic agonist that causes sedation and does have some analgesic properties. It has minimal effect on ... Additionally, some agents have antagonists, reversal agents, that can be used to reverse the effects or reduce the amount of ...
Patients taking strong dopaminergic antagonists such as those used in the treatment of psychosis are more likely than the ... Further support for the monoamine hypothesis came from monoamine depletion studies: Alpha-methyl-p-tyrosine (AMPT) is a ... at functionally important adrenergic receptor sites in the brain. However, elation may be associated with an excess of such ... Although their primary mechanisms of action are as NMDA receptor antagonists, ketamine and phencyclidine are also SNDRIs and ...
Combination therapy with dronabinol and the alpha 2 adrenergic receptor agonist lofexidine have shown mixed results, with ... Naltrexone, a mu opioid receptor antagonist, has shown mixed results for cannabis use disorder-both increasing the subjective ... antagonist, and modulation of other neurotransmitter systems.[4][40] More broadly, the goal of medication therapy for cannabis ... The CB-1 receptor antagonist rimonabant has shown efficacy in reducing the effects of cannabis in users, but with a risk for ...
... drugs which are selective receptor antagonists of CysLTR1 but not CysLTR2.[20][21][22][23] Models of allergic reactions in ... see Gq alpha subunit#function and Ga subunit#function for details); the order of potency of the cysLTs in stimulating CysLTR2 ... is a G protein-coupled receptor that links to and when bound to its CysLT ligands activates the Gq alpha subunit and/or Ga ... a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma". Journal of Medicinal Chemistry. 58 (15): 6093-113. doi: ...
Among other alkaloids is corynanthine, an alpha-1 adrenergic receptor blocker and raubasine. Extracts from the bark of yohimbe ... ISBN 9789290814955 Doxey, JC; Lane AC; Roach AG; Virdee NK (Feb 1984). "Comparison of the alpha-adrenoceptor antagonist ...
Alpha-adrenergic antagonists. Class Summary. These agents are used in the treatment of benign prostatic hypertrophy. Studies ... An alpha-adrenergic blocker, specifically targeting the A1 receptors, tamsulosin has the advantage of causing relatively less ... alpha-Blockers for Treatment of the Prostatitis Syndromes. Rev Urol. 2005. 7 Suppl 8:S18-25. [Medline]. [Full Text]. ... Alpha-blockers reduce bladder outlet obstruction and thus improve voiding dysfunction that may be associated with prostatic ...
Helping you find trustworthy answers on Alpha Adrenergic Antagonist , Latest evidence made easy ... Find all the evidence you need on Alpha Adrenergic Antagonist via the Trip Database. ... Alpha Adrenergics Alpha Adrenergic Agonist (Alpha Adrenergic Receptor) Alpha Non-Specific Alpha 1 Selective Methoxamine Alpha 2 ... 100968571 1471-2490 0 Adrenergic alpha-Antagonists 0 Muscarinic Antagonists IM Adrenergic alpha-Antagonists administration & ...
Alpha-adrenergic agonists. Class Summary. These agents stimulate alpha-adrenoreceptors in brain stem, activating an inhibitory ... A central alpha-adrenergic agonist that suppresses peripheral release of norepinephrine, resulting in lower blood pressure; ... A pure peripheral alpha-adrenergic agonist, which causes peripheral vasoconstriction and raises blood pressure without ... H2 receptor antagonists. Class Summary. These agents are reversible competitive blockers of histamine at the H2 receptors, ...
3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors.. Perry BD, ... 3H]Rauwolscine, a specific and potent alpha 2-antagonist radioligand, was used to characterize alpha 2-receptor binding in ... These results suggest that [3H]rauwolscine specifically labels both the high and low affinity states of the alpha 2-receptor in ... rauwolscine labeled the alpha 2-receptor. Agonists inhibited [3H]rauwolscine binding in a shallow, GTP-sensitive manner. ...
Prophylactic alpha-adrenergic antagonists were initiated five days prior to SBRT and continued until resolution of urinary ... Prophylactic alpha-adrenergic antagonists were initiated five days prior to SBRT and continued until resolution of urinary ... Conclusions: SBRT for localized prostate cancer with utilization of prophylactic alpha-adrenergic antagonist and UDR was well ... rates of acute urinary morbidity following SBRT for localized prostate cancer with prophylactic alpha-adrenergic antagonist ...
... and their use as selective alpha 1a adrenergic receptor antagonists. One application of these componds is in the treatment of ... These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without ... Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such ... EN) ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS. (FR) ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1a. ...
... alpha.-adrenergic receptor antagonists, compositions comprising .alpha.-adrenergic receptor antagonists that are optionally ... adrenergic receptor antagonists: NO.sub.n -.alpha.-antagonists where n is 1 or 2. The .alpha.-adrenergic antagonists can be ... A kit comprising an imidazoline .alpha.-adrenergic receptor antagonist, wherein the imidazoline .alpha.-adrenergic receptor ... 1. A composition comprising an imidazoline .alpha.-adrenergic receptor antagonist, wherein the imidazoline .alpha.-adrenergic ...
Central Alpha-Agonist Agents, Alpha-Adrenergic Receptor Blockers, Direct Vasodilators, and Exogenous Nitric Oxide Donors. ... Central Alpha-Agonist Agents, Alpha-Adrenergic Receptor Blockers, Direct Vasodilators, and Exogenous Nitric Oxide Donors", ... Central Alpha-Agonist Agents, Alpha-Adrenergic Receptor Blockers, Direct Vasodilators, and Exogenous Nitric Oxide Donors ... Carlos G. Musso and Jose Alfie, "Resistant Hypertension in the Elderly-Second Line Treatments: Aldosterone Antagonists, ...
We previously demonstrated that alpha-1 adrenergic receptor ($\alpha_1$-AR) antagonists can prevent cytokine storm syndrome in ... Title:Alpha-1 adrenergic receptor antagonists to prevent acute respiratory distress syndrome and death from cytokine storm ... These results highlight the urgent need for prospective trials testing whether prophylactic use of $\alpha_1$-AR antagonists ... alpha_1$-AR antagonists, as compared to nonusers, had a 40% relative risk reduction for ventilation and dying (p=0.014). We ...
... alpha 1 or alpha 2):. *Selective alpha antagonists only block alpha 1 receptors and are more commonly used for treatment of ... Nonselective alpha antagonists (alpha 1 and alpha 2 blockers) are used in the treatment of various types of peripheral vascular ... Potential side effects of alpha blockers. Selective alpha antagonists (alpha 1 blockers) can cause one or more of the following ... Selective alpha antagonists (alpha 1 blockers) include prazosin, terazosin and doxazosin. These drugs are sometimes used to ...
Find out information about alpha-adrenergic antagonist. 1. the first letter in the Greek alphabet , a vowel transliterated as a ... 2. Brit the highest grade or mark, as in an examination 3. a. involving or relating... Explanation of alpha-adrenergic ... alpha. (redirected from alpha-adrenergic antagonist). Also found in: Dictionary, Thesaurus, Medical, Legal, Financial. alpha. 1 ... Alpha-adrenergic antagonist , Article about alpha-adrenergic antagonist by The Free Dictionary https://encyclopedia2. ...
... and beta 2 adrenergic antagonists on the Na and K concentrations of sympathetic-nerve stimulated rat saliva.: Selective alpha ... Effects of alpha, beta 1, and beta 2 adrenergic antagonists on the Na and K concentrations of sympathetic-nerve stimulated rat ... Selective alpha and beta 1 and beta 2 adrenergic antagonists were used with electrical stimulation of the sympathetic ...
Alpha Adrenergic Antagonists. The pharmacokinetic and pharmacodynamic interactions between Uroxatral and other alpha adrenergic ... Caution is advised when alpha adrenergic antagonists, including Uroxatral, are coadministered with PDE5 inhibitors. Alpha ... However, interactions may be expected, and Uroxatral should not be used in combination with other alpha adrenergic antagonists. ... has been reported in some patients on or previously treated with alpha adrenergic antagonists. ...
Combination with Alpha-adrenergic Antagonist. Dutasteride Capsules in combination with the alpha-adrenergic antagonist, ... Approximately 52% of subjects had previous exposure to 5 alpha-reductase inhibitor or alpha adrenergic antagonist treatment. Of ... Combination with Alpha-adrenergic Antagonist. The recommended dose of dutasteride is 1 capsule (0.5 mg) taken once daily and ... Alpha Adrenergic Antagonists: In a single-sequence, crossover trial in healthy volunteers, the administration of tamsulosin or ...
Explore the 20 possible supplements interactions for Adrenergic Alpha-Antagonists and the research papers that mention these ... Adrenergic Alpha-Antagonists. A.K.A: alpha-adrenergic antagonist, alpha adrenergic blocking agents, …(more) ...
Agonist versus antagonist binding to alpha-adrenergic receptors. Proceedings of the National Academy of Sciences of the United ... Human platelet alpha 2-adrenergic receptors: labeling with 3H-yohimbine, a selective antagonist ligand. (opens in new tab) ... Human platelet alpha 2-adrenergic receptors: labeling with 3H-yohimbine, a selective antagonist ligand. (opens in new tab) ... However, in the liver, alpha-adrenergic effects such as glycogen phosphorylase activation are shown to be mediated via alpha 1 ...
Dapiprazole is an alpha-adrenergic blocking agent. It produces miosis by blocking the alpha-adrenergic receptors on the dilator ... Used in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic ( ...
These drugs are also called alpha-adrenergic antagonists, alpha-adrenergic blocking agents and alpha-adrenergic blockers. ... alpha-adrenergic antagonists and alpha-adrenergic blockers.. Related: Types of Blood Pressure Medications. alpha blockers Alpha ... alpha adrenergic antagonists Alpha-adrenergic antagonists are drugs used to lower blood pressure. They work by relaxing the ... These drugs are also called alpha blockers, alpha-adrenergic antagonists and alpha-adrenergic blocking agents. ...
1.2 Combination with Alpha-adrenergic Antagonist. Dutasteride in combination with the alpha-adrenergic antagonist, tamsulosin, ... 7.2 Alpha-adrenergic Antagonists 7.3 Calcium Channel Antagonists 7.4 Cholestyramine 7.5 Digoxin 7.6 Warfarin 8 USE IN SPECIFIC ... Approximately 52% of subjects had previous exposure to 5 alpha-reductase inhibitor or alpha-adrenergic antagonist treatment. Of ... 1.2 Combination with Alpha-adrenergic Antagonist 1.3 Limitations of Use 2 DOSAGE AND ADMINISTRATION 2.1 Monotherapy 2.2 ...
1.2 Combination With Alpha Adrenergic Antagonist Dutasteride in combination with the alpha adrenergic antagonist, tamsulosin, ... 7.2 Alpha Adrenergic Antagonists 7.3 Calcium Channel Antagonists 7.4 Cholestyramine 7.5 Digoxin 7.6 Warfarin 8 USE IN SPECIFIC ... Approximately 52% of subjects had previous exposure to 5 alpha-reductase inhibitor or alpha adrenergic antagonist treatment. Of ... 1.2 Combination With Alpha Adrenergic Antagonist 1.3 Limitations of Use 2 DOSAGE AND ADMINISTRATION 2.1 Monotherapy 2.2 ...
As an alpha-adrenergic blocking agent, terazosin is used to treat hypertension and benign prostatic hypertrophy (BPH). ...
Alpha-adrenergic Antagonists and Antihypertensives. Clonidine transdermal patch has shown some benefit in four CRPS patients ... Systemic alpha-adrenergic blockage with phentolamine: a diagnostic test for sympathetically maintained pain. Anesthesiol. 1991; ... N-methyl-d-aspartate (NMDA) Receptor Antagonists. Anesthetic doses of ketamine, an NMDA receptor antagonist, have been used ... Another NMDA receptor antagonist, amantadine 200 mg IV, has been used to treat neuropathic cancer pain (n = 15).18 In this ...
Alpha-1 adrenergic antagonist properties.. Experiments were carried out in rats (270-390 g) that had free access to water and ... Thealpha-1-adrenergic antagonist, prazosin, tested at doses up to 160 mg/kg, was unable to protect from the effects of ... and alpha-1 adrenergic antagonist activity (inhibition of the pressor response induced by methoxamine; ○) after i.p. ... and had a 70-fold separation between its 5-HT1Aagonist and alpha-1 adrenergic antagonist properties (measured as the ability to ...
Alpha-2 adrenergic antagonist Increase blood pressure Yohimbine[111] Prognosis[edit]. POTS has a favorable prognosis when ... Alpha-1 adrenergic receptor agonist Constrict the peripheral blood vessels aiding venous return. Midodrine[17][89][90][91] ... alpha-2 adrenergic receptor agonist Decreases blood pressure and sympathetic nerve traffic. Clonidine,[12] Methyldopa[12] ... Antibodies against the Alpha 1 adrenergic receptor and muscarinic acetylcholine M4 receptor[4][5][6]. ...
Interaction of Imidazoline Alpha-Adrenergic Receptor Antagonists with Histamine Receptors. Powell, James R.; Shamel, L. Blair ... Thyroxine and Propylthiouracil Effects on Alpha- and Beta-Adrenergic Receptor Number, ATPase Activities, and Sialic Acid ...
Adrenergic alpha-Antagonists / administration & dosage* * Aged * Aged, 80 and over * Humans * Male ... Natural course of lower urinary tract symptoms following discontinuation of alpha-1-adrenergic blockers in patients with benign ... Objective: alpha1-adrenergic blockers (alphab) remain the first-line therapy in men with lower urinary tract symptoms (LUTS). ...
Platelet alpha 2-adrenergic receptor density is increased in hypercholesterolemia and directly correlates with plasma total and ... Receptors, Adrenergic, alpha-2 / metabolism* * Yohimbine / metabolism Substances * Adrenergic alpha-Antagonists * Lipids ... Conclusion: Platelet alpha 2-adrenergic receptor density is increased in hypercholesterolemia and directly correlates with ... Platelet alpha 2-adrenergic receptors in hypercholesterolemia: relationship between binding studies and epinephrine-induced ...
Progesterone possesses GABA agonist, glutamate antagonist, and alpha-adrenergic antagonist properties. Laboratory studies have ... Labetalol, an alpha- and beta-adrenergic blocker, attenuates some of the physiologic effects of cocaine but has not been shown ... Overall, adrenergic receptor antagonists seem to be effective in reducing or blocking the physiologic effects of acute cocaine ... Cocaine stimulates dopamine and alpha- and beta-adrenergic receptors in the CNS and in the peripheral nervous system, which is ...
alpha-adrenergic antagonists. *antihistamines. *diuretics. *muscle relaxants and sedatives. *narcotics, such as oxycodone and ...
alpha-adrenergic antagonists. *antihistamines. *diuretics. *muscle relaxants and sedatives. *narcotics, such as oxycodone and ...
  • The H2 antagonists are highly selective, do not affect the H1 receptors, and are not anticholinergic agents. (medscape.com)
  • 3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. (nih.gov)
  • They are called alpha blockers because they block the microscopic areas in the heart called alpha receptors . (nmihi.com)
  • These alpha receptors are normally activated by certain chemicals in the brain, such as the hormones released during stress (e.g., adrenaline). (nmihi.com)
  • When activated by these chemicals, the alpha receptors trigger a reaction that speeds the heart rate, increases the force of the heartbeat and constricts the blood vessels. (nmihi.com)
  • However, this reaction cannot be triggered if the chemicals are blocked by alpha blockers from activating or binding to the alpha receptors. (nmihi.com)
  • Selective alpha antagonists only block alpha 1 receptors and are more commonly used for treatment of cardiac conditions. (nmihi.com)
  • Nonselective alpha antagonists can bind with both types of receptors and are generally not used for cardiology treatments because blocking both receptors can cause tachycardia (rapid heart beat) and palpitations (pounding heart beat). (nmihi.com)
  • It produces miosis by blocking the alpha-adrenergic receptors on the dilator muscle of the iris. (pharmacycode.com)
  • The platelet contains exclusively alpha 2 and the liver mostly (approximately 80%) alpha 1 receptors. (meta.org)
  • Agonists induce the formation of a guanine nucleotide-sensitive high-affinity state of alpha 2 but not alpha 1 receptors. (meta.org)
  • 3H]Dihydroergocryptine labels all the alpha receptors, whereas [3H]epinephrine at low concentrations labels predominantly the high-affinity form of the alpha 2 receptor in both platelet and liver. (meta.org)
  • However, in the liver, alpha-adrenergic effects such as glycogen phosphorylase activation are shown to be mediated via alpha 1 receptors. (meta.org)
  • Thus, in liver membranes the endogenous 'physiological' agonist may not label the physiologically relevant alpha 1 receptors in typical radioligand binding assays using low concentrations of [3H]epinephrine. (meta.org)
  • Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. (meta.org)
  • An agent that binds to but does not activate alpha -adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha -adrenergic agonists. (ebi.ac.uk)
  • H 1 -receptor antagonists are the drugs that selectively bind to but do not activate histamine H 1 receptors, thereby blocking the actions of endogenous histamine. (ebi.ac.uk)
  • Bladder muscles, particularly the neck of the bladder, contain large amounts of receptors sensitive to alpha agonists. (healthhype.com)
  • Blocks Alpha-1 receptors in blood vessels (arteries and veins). (exrx.net)
  • Role of adrenergic alpha-2-receptors on feeding behavior in layer-type chicks. (biomedsearch.com)
  • The present study was designed to investigate the role of brain adrenergic alpha-2-receptors on feeding regulation of layer-type chicks. (biomedsearch.com)
  • It is therefore likely that brain adrenergic alpha-2-receptors mediate the orexigenic effects of neuropeptide Y and beta-endorphin in layer-type chicks. (biomedsearch.com)
  • A drug that blocks or counteracts the effects of epinephrine and other molecules that stimulate alpha-receptors, leading to various physiological reactions such as vasodilation and a decrease in blood pressure. (thefreedictionary.com)
  • The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. (fpnotebook.com)
  • also used to distinguish types of radioactive decay, brain waves or rhythms, adrenergic receptors, and secretory cells that stain with acid dyes, such as the alpha cells of the pancreas. (thefreedictionary.com)
  • alpha-adrenergic blocking agent ( alpha-blocker ) ( alpha-blocking agent ) any of a group of drugs that selectively inhibit the activity of alpha receptors in the sympathetic nervous system. (thefreedictionary.com)
  • Phenylephrine hydrochloride acts predominantly on the alpha 1 receptors of the iris. (aao.org)
  • These latter antipsychotics have antagonistic actions at several receptors, including alpha -1 and alpha -2 adrenergic, M1 muscarinic and γ-aminobutyric acid (GABA)-A receptors. (aspetjournals.org)
  • The present studies examined the possibility that an antagonist action at a particular receptor subtype might be responsible for the interaction between PCP and the clozapine-like antipsychotics by testing whether a selective antagonist at alpha -1, alpha -2, M1 or GABA-A receptors would prevent the PCP-induced deficit in PPI in rats. (aspetjournals.org)
  • The antagonists for alpha -2, for M1 and for GABA-A receptors had no effect on base-line PPI or on PCP-induced disruptions in PPI. (aspetjournals.org)
  • These findings indicate that the PPI-disruptive effect of PCP may be mediated in part by alpha -1 adrenergic receptors and that antagonism of alpha -1 receptors may play a major role in mediating the blockade of PCP-induced deficits in PPI by certain antipsychotics. (aspetjournals.org)
  • RAPAFLO (TM) maximizes target organ activity by binding with high affinity to the alpha (1A) receptors concentrated in the prostate. (bio-medicine.org)
  • By this second component of the mechanism, the same stimulus directly acts on the carbonic anhydrase I isozyme (that might be functionally coupled with adrenergic receptors), so that its activation ensures an adequate pH for stimulus-receptor coupling for signal transduction into the cell, resulting in vasoconstriction. (scielo.br)
  • Important factors in the response of any cell or organ to sympathomimetic amines are the density and proportion of alpha- and beta-adrenergic receptors (3,4). (scielo.br)
  • Studies on DNA cloning have demonstrated the existence of at least nine types of adrenergic receptors (5). (scielo.br)
  • Etilefrine is an adrenergic agonist that appears to interact with beta-2 and some alpha adrenergic receptors. (drugbank.ca)
  • Cirazoline acts on a number of α adrenergic receptors. (drugbank.ca)
  • pharmacology) A drug which blocks α1-adrenergic receptors in arteries and smooth muscles. (yourdictionary.com)
  • More adrenaline production can lead to what we wrongfully refer to as "CNS fatigue" either by depleting dopamine (adrenaline is made from dopamine) or a desensitization of the adrenergic receptors due to overstimulation. (t-nation.com)
  • This drug category may also be called central-acting agents, central alpha agonists, or central adrenergic inhibitors. (healthcentral.com)
  • Research suggests that beta-2 adrenergic agonists can help reduce fat. (bodybuilding.com)
  • We studied the relationship between alpha- and beta-adrenergic agonists and the activity of carbonic anhydrase I and II in erythrocyte, clinical and vessel studies. (scielo.br)
  • We believe that adrenergic agonists may have a dual mechanism of action: the first one consists of a catecholamine action on its receptor with the formation of a stimulus-receptor complex. (scielo.br)
  • Our previous work has shown that alpha- and beta-adrenergic agonists activated purified and red cell CA while adrenergic antagonists inhibited CA and reduced the activating effect of agonists on this enzyme (15,16). (scielo.br)
  • In the present investigation we studied the relationship between alpha- and beta-adrenergic agonists and CA activity in vasoconstriction mechanism. (scielo.br)
  • The authors note the limited utility of NMDA receptor antagonists and alpha-2 adrenergic agonists. (lww.com)
  • Importance of Alpha - adrenergic Receptor Subtypes in Regulating of Airways Tonus at Patients with Bronchial Asthma In this work, effect of Tamsulosin hydrochloride as antagonist of alpha1A and alpha1B- adrenergic receptor and effect of Salbutamol as agonist of beta2- adrenergic receptor in patients with bronchial asthma and increased bronchial reactibility was studied.Parameters of the lung function are determined by Body plethysmography. (tripdatabase.com)
  • Carlos G. Musso and Jose Alfie, "Resistant Hypertension in the Elderly-Second Line Treatments: Aldosterone Antagonists, Central Alpha-Agonist Agents, Alpha-Adrenergic Receptor Blockers, Direct Vasodilators, and Exogenous Nitric Oxide Donors", Cardiovascular & Hematological Agents in Medicinal Chemistry (2014) 12: 170. (eurekaselect.com)
  • The binding properties of two alpha-adrenergic radioligands, [3H]epinephrine (an agonist) and [3H]dihydroergocryptine (an antagonist), were compared in two model systems--membranes derived from human platelets and membranes from rat liver. (meta.org)
  • Intracerebroventricular injection of the adrenergic alpha-2-receptor agonist, clonidine, stimulated food intake. (biomedsearch.com)
  • An alpha-2 selective adrenergic agonist used as an antihypertensive agent. (fpnotebook.com)
  • An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. (fpnotebook.com)
  • One of those constituents is higenamine a beta-2 adrenergic agonist. (bodybuilding.com)
  • Synephrine is an adrenergic agonist of beta-1. (illpumpyouup.com)
  • An alpha-1A adrenoceptor agonist used to treat nasal congestion, allergic reactions of the eye, and facial erythema associated with rosacea. (drugbank.ca)
  • An alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics. (drugbank.ca)
  • An alpha-adrenergic agonist used in the temporary symptomatic relief of discomfort and redness of the eyes due to minor irritations. (drugbank.ca)
  • A alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. (drugbank.ca)
  • An alpha adrenergic agonist used to treat hypotension. (drugbank.ca)
  • An alpha and beta adrenergic agonist used to treat nasal and sinus congestion, as well as allergic rhinitis. (drugbank.ca)
  • An alpha and beta-adrenergic agonist indicated to treat hypotension under anesthesia, allergic conditions, bronchial asthma, and nasal congestion. (drugbank.ca)
  • It is an agonist of α1A, partial agonist of α1B and α1D, and a nonselective antagonist of α2. (drugbank.ca)
  • Selective alpha antagonists (alpha 1 blockers) include prazosin, terazosin and doxazosin. (nmihi.com)
  • Animals were pretreated with either the alpha -1 antagonist prazosin (0, 0.5, 1.0 or 2.5 mg/kg), the alpha -2 antagonist RX821002 (0, 0.2 or 0.4 mg/kg), the M1 muscarinic antagonist pirenzepine (0, 10 or 30 mg/kg) or the GABA-A antagonist pitrazepin (0, 1.0 or 3.0 mg/kg) and then treated with either saline or PCP (1.5 mg/kg). (aspetjournals.org)
  • An appropriate therapy for RH can be achieved by the addition of second line antihypertensive drugs: antialdosteronic diuretics, central agents, alpha blockers, direct vasodilating agents, and exogenous nitric oxide donors. (eurekaselect.com)
  • Alpha blockers are non-habit-forming medications. (nmihi.com)
  • Therefore, alpha blockers relieve cardiac stress by slowing the heart rate and reducing the force of heart muscle contractions (the pumping action). (nmihi.com)
  • Because they affect stress hormones, alpha blockers result in a lowering of blood pressure (the force of blood against artery walls). (nmihi.com)
  • Alpha 1 blockers decrease resistance within blood vessels and increase vein capacity, increasing the flow of blood in the heart and reducing cardiac output - a measure of the heart's workload. (nmihi.com)
  • Alpha 1 blockers have also been found effective in the prevention and treatment of post-traumatic stress disorder, particularly in reducing trauma-related nightmares. (nmihi.com)
  • However, alpha 1 blockers may also have pronounced side effects and, as shown in the ALLHAT trials, doxazosin may increase the risk of heart failure over long-term use. (nmihi.com)
  • As with other alpha blockers, postural hypotension (decreasing blood pressure upon standing, with or without dizziness) may develop within a few hours following ingestion of alfuzosin and can cause fainting. (medicinenet.com)
  • alpha1-adrenergic blockers (alphab) remain the first-line therapy in men with lower urinary tract symptoms (LUTS). (nih.gov)
  • Alpha-blockers are used to treat the symptoms of many conditions, such as benign prostatic hyperplasia (BPH), high blood pressure, and some blood circulation problems. (cancer.gov)
  • However, literature about the use of alpha-1 adrenergic blockers in pediatric population with distal ureterolithiasis is still scarce. (scielo.br)
  • This review has the objective to evaluate the use of alpha-1 adrenergic blockers as medical expulsive treatment in children with distal ureterolithiasis. (scielo.br)
  • In the adult patient, there are various conservative treatments to treat calculi smaller than 12mm, such as the use of calcium blockers, non-steroidal anti-inflammatory agents, or alpha-1 adrenergic blockers, which is the better approach ( 9 ). (scielo.br)
  • Antihypertensive agents include diuretics, alpha-adrenergic and beta-adrenergic antagonists, angiotensin-converting enzyme inhibitors, calcium channel blockers, ganglionic blockers, and vasodilator agents. (fpnotebook.com)
  • Alpha blockers inhibit the actions of norepinephrine. (healthcentral.com)
  • Alpha blockers relax muscles to allow for wider blood vessels and lower blood pressure. (healthcentral.com)
  • Like calcium channel blockers, there are short-acting and long-acting forms of alpha blockers. (healthcentral.com)
  • Beta adrenergic blockers. (flashcardmachine.com)
  • The study was limited to patients using tamsulosin because the incidence of IFIS in these patients is more frequent and severe than with other nonselective alpha-adrenergic blockers, Dr. Lorente said. (aao.org)
  • Alpha blockers are used in combination with other drugs to treat high blood pressure and can treat prostate problems in men. (mayoclinic.org)
  • Alpha blockers lower blood pressure by keeping the hormone norepinephrine from tightening the muscles in the walls of smaller arteries and veins. (mayoclinic.org)
  • Because alpha blockers also relax other muscles throughout the body, these medications also can help improve urine flow in older men with prostate problems. (mayoclinic.org)
  • Alpha blockers are either short-acting or long-acting. (mayoclinic.org)
  • Alpha blockers are also called alpha-adrenergic blocking agents, alpha-adrenergic antagonists, adrenergic blocking agents and alpha-blocking agents. (mayoclinic.org)
  • Alpha blockers typically aren't the first treatment option for high blood pressure. (mayoclinic.org)
  • In addition to high blood pressure, doctors prescribe alpha blockers to prevent, treat or improve symptoms of an enlarged prostate (benign prostatic hyperplasia). (mayoclinic.org)
  • Some alpha blockers might have a "first-dose effect. (mayoclinic.org)
  • Before taking an alpha blocker, be sure your doctor knows about other medications you take, such as beta blockers, calcium channel blockers or medications for erectile dysfunction. (mayoclinic.org)
  • Alpha blockers can increase or decrease the effects of other medications you take. (mayoclinic.org)
  • Alpha blockers may improve total cholesterol. (mayoclinic.org)
  • However, some research has found that long-term use of some alpha blockers can increase the risk of heart failure. (mayoclinic.org)
  • Dutasteride Capsules in combination with the alpha-adrenergic antagonist, tamsulosin, is indicated for the treatment of symptomatic BPH in men with an enlarged prostate. (drugs.com)
  • The most studied alpha-blocker has been tamsulosin, although a class effect has been suggested. (thefreedictionary.com)
  • Tamsulosin is an alpha blocker, prescribed for benign prostatic hyperplasia (BPH) or prostate enlargement. (medindia.net)
  • IFIS has been associated with systemic administration of tamsulosin and other alpha-adrenergic receptor antagonists. (aao.org)
  • Considering that phenylephrine was effective enough to prevent IFIS in the worst possible scenario-intake of tamsulosin-we assume that it will have the same prophylactic effect with the remaining alpha-antagonists, since IFIS is less common and severe with those," Dr. Lorente said. (aao.org)
  • Patients with previously demonstrated, clinically significant hypersensitivity (e.g., serious skin reactions, angioedema) to dutasteride or other 5 alpha-reductase inhibitors [see Adverse Reactions (6.2) ]. (drugs.com)
  • 5 alpha-reductase inhibitors may increase the risk of development of high-grade prostate cancer. (drugs.com)
  • Patients with previously demonstrated, clinically significant hypersensitivity (e.g., serious skin reactions, angioedema) to dutasteride capsules or other 5 alpha-reductase inhibitors. (nih.gov)
  • Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. (ebi.ac.uk)
  • Management of benign prostate hyperplasia (BPH) by combinatorial approach using alpha-1-adrenergic antagonists and 5-alpha-reductase inhibitors. (unimore.it)
  • Currently, the main available treatments for benign prostate hyperplasia (BPH) are alpha-1 adrenergic receptor antagonists (ARAs), 5-alpha reductase inhibitors (5-αRI), anticholinergics, and Phosphodiesterase-5 inhibitors. (unimore.it)
  • Clinical efficacy and tolerability of alpha-blocker doxazosin as add-on therapy in patients with hypertension and impaired glucose metabolism. (nextbio.com)
  • PURPOSE: The aim of this study was to assess the effects of acute systemic, nonselective alpha-adrenergic blockade on aqueous flow. (biomedsearch.com)
  • A nonselective alpha-adrenergic antagonist. (bioportfolio.com)
  • Any confirmed increase from the lowest PSA value while on dutasteride may signal the presence of prostate cancer and should be evaluated, even if PSA levels are still within the normal range for men not taking a 5 alpha-reductase inhibitor. (drugs.com)
  • We identified WB4101 (2-(2,6-Dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane hydrochloride), an antagonist of α 1 -adrenoceptor, as a Nav1.7 inhibitor from a screen. (aspetjournals.org)
  • The link between heart failure risk and alpha blocker use was one of the findings of the landmark ALLHAT study (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). (nmihi.com)
  • Metazosin is an antihypertensive alpha-adrenergic antagonist. (wikipedia.org)
  • To treat hypertension, a class of Antihypertensive medications called "angiotensin II receptor antagonists" may be prescribed. (blausen.com)
  • This effect was blocked by co-injection of the alpha-2-receptor antagonist, yohimbine, demonstrating that the alpha-2-receptor is related to stimulation of feeding in layer-type chicks. (biomedsearch.com)
  • Yohimbine acts as an alpha-2 adrenoceptor antagonist. (sigmaaldrich.com)
  • Yohimbine acts centrally to increase sympathetic outflow, and peripherally to increase the release of norepinephrine from adrenergic nerve terminals. (sigmaaldrich.com)
  • Yohimbine may act via blockade of postsynaptic alpha-2 adrenoceptors to produce insulinotropic and hypoglycemic effects. (sigmaaldrich.com)
  • 25 Since alpha-adrenoceptors are located in widespread locations throughout the central and peripheral nervous system, yohimbine has a variety of autonomic and psychic effects (increased noradrenaline release). (sigmaaldrich.com)
  • Yohimbine HCL is an Alpha 2-adrenergic antagonist. (bodybuilding.com)
  • Simply put, in the fat cell, the alpha 2 adrenergic receptor is the off switch for fat release, as such Yohimbine HCL being an alpha 2-adrenergic antagonist helps block the off switch, creating fat release. (bodybuilding.com)
  • We aimed to investigate the relationship of alpha2-receptor dysregulation with learning processes in MDD by conducting a differential fear conditioning paradigm after double-blind administration of the alpha2-receptor antagonist yohimbine versus placebo. (tripdatabase.com)
  • The alpha-2 adrenergic receptor antagonist, yohimbine , can facilitate fear extinction in animals and humans. (tripdatabase.com)
  • As an alpha-adrenergic blocking agent, terazosin is used to treat hypertension and benign prostatic hypertrophy (BPH). (pharmacycode.com)
  • This increase in PRA was blocked by phentolamine, suggesting a vascular alpha-adrenergic receptor-mediated release of renin. (ahajournals.org)
  • Observational Study in Patients Suffering From Benign Prostatic Hyperplasia Treated With Alpha - adrenergic Blockade Observational Study in Patients Suffering From Benign Prostatic Hyperplasia Treated With Alpha - adrenergic Blockade - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. (tripdatabase.com)
  • The second rise in PRA was increased by 30% with alpha-adrenergic blockade. (ahajournals.org)
  • The purpose of this study is to explore additional benefit of solifenacin after 12-week treatment, compared with alpha blocker monotherapy in men with residual OAB symptoms. (clinicaltrials.gov)
  • Also called alpha-adrenergic antagonist , alpha-adrenergic blocker . (thefreedictionary.com)
  • Its combination with an alpha-blocker is effective in improving irritative symptoms, and for select patients with BOO and concomitant detrusor overactivity. (thefreedictionary.com)
  • Labetalol is both a selective alpha-blocker and a nonselective beta-blocker that decreases systemic vascular resistance without changing maternal cardiac output. (thefreedictionary.com)
  • Our findings do not support this recommendation and should prompt reconsideration of use of an alpha-blocker as the first drug of choice for these patients," he added. (thefreedictionary.com)
  • Conventional medical therapy for an enlarged prostate includes alpha-blocker drugs such as Flomax to relax the smooth muscle in the prostate. (thefreedictionary.com)
  • We know that alpha-blocker drugs and Proscar can do the first, and it looks like a combination of the two can do the second," Wilt says. (thefreedictionary.com)
  • The first group consisted of patients receiving diclofenac sodium and an alpha-blocker , the second group of patients received diclofenac sodium and prednisolone, and the third group of patients received diclofenac sodium alone. (thefreedictionary.com)
  • Alpha-1 adrenergic blocker use is related with a greater incidence of expulsion of ureteral calculi, smaller or greater than 5mm, and fewer episodes of pain when compared to ibuprofen. (scielo.br)
  • 8. alpha blocker$.tw. (bestbets.org)
  • Naftopidil is a selective α1-adrenergic receptor antagonist or alpha blocker. (medindia.net)
  • RAPAFLO (TM) is a new, uniquely selective alpha blocker for the treatment of the signs and symptoms of BPH, launched earlier this month by Watson Pharmaceuticals, a leader in generic and specialty branded pharmaceuticals. (bio-medicine.org)
  • How would you define alpha blocker? (yourdictionary.com)
  • The alpha blocker that's best for you depends on your health and the condition being treated. (mayoclinic.org)
  • When you start taking an alpha blocker, you might develop pronounced low blood pressure and dizziness, which can make you faint when you rise from a sitting or lying position. (mayoclinic.org)
  • Uroxatral ( alfuzosin ) is a selective antagonist of post-synaptic alpha1-adrenoreceptors used in adult men to treat slow urination due to benign prostatic hyperplasia ( BPH ). (medicinenet.com)
  • The current project aims to test the safety, tolerability and efficacy of Nuedexta - containing the NMDA antagonist dextromethorphan. (clinicaltrials.gov)
  • Ketamine - a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist - has now been demonstrated in several studies to bring about a rapid and robust antidepressant effect, even in patients suffering from TRD. (clinicaltrials.gov)
  • Dextromethorphan (DM) is a low-affinity uncompetitive antagonist of the N-Methyl-D-aspartate (NMDA) receptor, reducing the level of excitatory activity. (clinicaltrials.gov)
  • PCP-induced deficits in PPI in rats are resistant to dopamine and serotonin antagonists but can be antagonized by antipsychotics such as clozapine, olanzapine and Seroquel. (aspetjournals.org)
  • alpha -Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (ebi.ac.uk)
  • A selective adrenergic alpha-1 antagonist used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud's syndrome, prostatic hypertrophy, and urinary retention. (bioportfolio.com)
  • There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. (wikipedia.org)
  • As with beta-adrenergic blocking agents , alpha-blocking agents compete with the catecholamines at peripheral autonomic receptor sites. (thefreedictionary.com)
  • This study reports rates of acute urinary morbidity following SBRT for localized prostate cancer with prophylactic alpha-adrenergic antagonist utilization and urethral dose reduction (UDR). (frontiersin.org)
  • Prophylactic alpha-adrenergic antagonists were initiated 5 days prior to SBRT and continued until resolution of urinary symptoms. (frontiersin.org)
  • Stereotactic body radiation therapy for localized prostate cancer with utilization of prophylactic alpha-adrenergic antagonist and UDR was well tolerated as determined by acute urinary function and bother, and symptoms were comparable to those observed following conventionally fractionated external beam radiation therapy (EBRT). (frontiersin.org)
  • These results highlight the urgent need for prospective trials testing whether prophylactic use of $\alpha_1$-AR antagonists ameliorates diseases associated with cytokine storm syndrome, such as COVID-19. (arxiv.org)
  • β2- Adrenergic Receptor-Mediated HIF-1α Upregulation Mediates Blood Brain Barrier Damage in Acute Cerebral Ischemia Disruption of the blood brain barrier (BBB) within the thrombolytic time window is an antecedent event to intracerebral hemorrhage in ischemic stroke. (tripdatabase.com)
  • Acute and chronic intrarenal alpha- and beta- adrenergic receptor stimulation of renin release in the conscious dog. (ahajournals.org)
  • 9. The method of claim 8, wherein said adrenergic blocking agent is tolazoline hydrochloride. (google.com.au)
  • Two yet to be launched products, Forest Laboratories/Cypress Biosciences's antidepressant milnacipran and Schwarz Pharma's sodium ion channel antagonist/CRMP2 modulator lacosamide (Vimpat), will compete for market share as well as provide the benefit of an additional mechanism of action. (massagemag.com)
  • The end result is that angiotensin II receptor antagonists prevent blood vessels from narrowing, thereby keeping a normal blood pressure. (blausen.com)
  • Ergot alkaloid and alpha adrenergic receptor antagonist with vasoconstrictor effect. (e-lactancia.org)
  • This study assessed whether platelet hyperreactivity to epinephrine in hypercholesterolemia is associated with higher alpha 2-adrenergic receptor density or affinity for epinephrine. (nih.gov)
  • Platelet alpha 2-adrenergic receptor density is increased in hypercholesterolemia and directly correlates with plasma total and levels of LDL cholesterol, providing at least a partial explanation for the enhanced platelet response to epinephrine that is observed in hypercholesterolemia. (nih.gov)
  • Used in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents used in certain eye examinations. (pharmacycode.com)
  • Medications (alpha adrenergic antagonists) that can relax the smooth muscle of the prostate and that reduce the pressure that causes the urethral obstruction are now being tested in Europe and the United States, but have not as yet received necessary Food and Drug Administration approval for use in the United States. (chicagotribune.com)
  • https://www.heart.org/en/health-topics/high-blood-pressure/changes-you-can-make-to-manage-high-blood-pressure/types-of-blood-pressure-medications. (mayoclinic.org)
  • Long-Term Vitamin K Antagonists and Cancer Risk: A Systematic Review and Meta-Analysis. (nih.gov)
  • This review analyzed the outcome of alpha adrenergic antagonist in children with ureteral calculi. (scielo.br)
  • There are several different brands of angiotensin II receptor antagonists. (blausen.com)
  • competitive non-selective benzodiazepine receptor antagonist. (brainscape.com)
  • Chronic prostatitis, chronic pelvic pain syndrome, and asymptomatic inflammatory prostatitis may be treated with alpha-blocking agents or diazepam with sitz baths. (medscape.com)
  • These agents stimulate alpha-adrenoreceptors in brain stem, activating an inhibitory neuron, which in turn results in reduced sympathetic outflow. (medscape.com)
  • This drug category may also be called beta-adrenergic blocking agents. (healthcentral.com)
  • Reply: Safety of Alpha-Adrenergic Receptor Antagonists in Heart Failure. (nih.gov)