A stage of development at which the ADRENAL GLANDS undergo maturation leading to the capability of producing increasing amounts of adrenal androgens, DEHYDROEPIANDROSTERONE and ANDROSTENEDIONE. Adrenarche usually begins at about 7 or 8 years of age before the signs of PUBERTY and continues throughout puberty.
The inner zone of the adrenal cortex. This zone produces the enzymes that convert PREGNENOLONE, a 21-carbon steroid, to 19-carbon steroids (DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE) via 17-ALPHA-HYDROXYPREGNENOLONE.
Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE.
An enzyme that catalyzes the reduction of a 3 beta-hydroxy-delta(5)-steroid to 3-oxo-delta(4)-steroid in the presence of NAD. It converts pregnenolone to progesterone and dehydroepiandrosterone to androstenedione. EC 1.1.1.145.
The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.
The 5-beta-reduced isomer of ANDROSTERONE. Etiocholanolone is a major metabolite of TESTOSTERONE and ANDROSTENEDIONE in many mammalian species including humans. It is excreted in the URINE.
The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.
Errors in metabolic processing of STEROIDS resulting from inborn genetic mutations that are inherited or acquired in utero.
The pygmy chimpanzee, a species of the genus Pan, family HOMINIDAE. Its common name is Bonobo, which was once considered a separate genus by some; others considered it a subspecies of PAN TROGLODYTES. Its range is confined to the forests of the central Zaire basin. Despite its name, it is often of equal size to P. troglodytes.
A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.
A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Cytochromes of the b group that are found bound to cytoplasmic side of ENDOPLASMIC RETICULUM. They serve as electron carrier proteins for a variety of membrane-bound OXYGENASES. They are reduced by the enzyme CYTOCHROME-B(5) REDUCTASE.
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
A metabolite of PROGESTERONE with a hydroxyl group at the 17-alpha position. It serves as an intermediate in the biosynthesis of HYDROCORTISONE and GONADAL STEROID HORMONES.
Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.
A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT.

Cytochrome b(5) modulation of 17{alpha} hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis. (1/28)

CYP17 is a steroidogenic enzyme located in the zona fasciculata and zona reticularis of the adrenal cortex and gonad tissues and which has dual functions - hydroxylation and as a lyase. The first activity gives hydroxylation of pregnenolone and progesterone at the C(17) position to generate 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone, while the second enzymic activity cleaves the C(17)-C(20) bond of 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone to form dehydroepiandro-sterone and androstenedione respectively. The modulation of these two activities occurs through cytochrome b(5). Association of cytochrome b(5) and CYP17 is thought to be based primarily on electrostatic interactions in which the negatively charged residues pair up with positively charged residues on the proximal surface of the CYP17 molecule. Non-specific interactions of the hydrophobic membrane regions of cytochrome b(5) and CYP17 are also thought to play a crucial role in the association of these two haemoproteins. Although cytochrome b(5) is known to stimulate CYP activity by contributing the second electron in the catalytic cycle, in the case of CYP17, the mechanism of cleavage stimulation proceeds via an allosteric mode. It is hypothesised that cytochrome b(5) promotes the cleavage by aligning the iron-oxygen complex attack onto the C(20) rather than the C(17) atom of the steroid substrate molecule. Thus, further understanding of the mechanism of modulation by cytochrome b(5) of the hydroxylase and lyase activities should shed new insights on developing therapeutic targets in CYP17-linked biochemical processes such as adrenarche, polycystic ovary syndrome and prostate cancer.  (+info)

Early puberty-menarche after precocious pubarche: relation to prenatal growth. (2/28)

OBJECTIVE: Girls with precocious pubarche (PP; pubic hair at <8 years of age) as a result of an early or amplified adrenarche (high dehydroepiandrosterone-sulfate [DHEAS]) tend to be hyperinsulinemic, in particular when born with low birth weight (LBW). The objective of this study was to assess the interrelationship among prenatal growth, PP, the timing of puberty-menarche, and adult stature. METHODS: We studied 187 PP girls longitudinally: (1) at birth, (2) in prepuberty, (3) at onset of puberty, (4) at menarche, and (5) on reaching adult stature. This PP cohort was divided into subgroups of higher birth weight (>0 SD), intermediate birth weight (0 to -2 SD), and lower birth weight (less than -2 SD). RESULTS: At the time of PP diagnosis, age, bone age, and BMI were similar across birth weight subgroups; circulating sex hormone-binding globulin and body height were reduced in PP girls with lower birth weight, and these remained so throughout pubertal development. Onset of puberty occurred earlier in PP girls with lower birth weight; so did menarche. Adult height differed by an average of 6.5 cm (approximately 1 SD) between the upper and lower birth weight subgroups; this difference was essentially achieved before puberty and even before PP. Menarche before age 12.0 years was twofold more prevalent in PP girls than in control subjects. Among PP girls, age at menarche was advanced by 8 to 10 months in lower versus higher birth weight girls. Menarche before age 12.0 years was threefold more prevalent among LBW-PP girls than in control subjects (approximately 75% vs approximately 25%). CONCLUSIONS: The link between prenatal growth restraint and early menarche is herewith extended to PP girls. In particular LBW-PP girls may become a target group for interventions directed toward normalization of pubertal onset and progression.  (+info)

Adrenarche in the rat. (3/28)

Normal pubertal development in humans involves two distinct processes: maturation of adrenal androgen secretion (adrenarche) and activation of the hypothalamic-pituitary-gonadal axis (gonadarche). One factor thought to contribute to the adrenarche in man is increased adrenal 17-hydroxylase (CYP17) activity. In the rat, there is evidence for adrenal involvement in the initiation of puberty, but the adrenal glands of this species are generally thought to express CYP17 only very poorly at best. To further examine the nature of postnatal adrenal development in rat, plasma samples and adrenal tissues were taken from animals aged 2-90 days, circulating adrenal steroids assayed, and adrenal zones assessed quantitatively. A relative increase in zona reticularis, and peaks of circulating cortisol, androstenedione, and 17-OH-progesterone were observed around postnatal days 16-20, clearly before the development of the gonads, which begins at 30-35 days. Quantitative reverse transcriptase PCR confirmed a peak in mRNA coding for CYP17 in adrenal tissue from rats of similar age. The results suggest that the rat adrenal has the capacity to secrete steroids arising from 17-hydroxylation, and that this may contribute to a process similar to human adrenarche.  (+info)

Differences in endocrine parameters and psychopathology in girls with premature adrenarche versus on-time adrenarche. (4/28)

Girls with premature adrenarche (PA) are at risk for multiple problems related to exaggerated androgen synthesis. Whether PA carries a risk of psychopathology remains unknown. This study examined group differences in: (a) anthropometric and endocrine parameters, and (b) mood and behavior problems, in 6-8 year-old girls with PA (n = 40) compared to on-time adrenarche girls (n = 36). PA girls were taller (p < or =0.05) and heavier (p < or =0.01) than the on-time adrenarche girls but body mass index showed no difference. PA girls had significantly (p <0.05) higher adrenal androgen and testosterone concentrations but not cortisol or leptin. PA girls also had significantly more oppositional defiant disorder, and higher symptom counts reflecting anxiety, mood or disruptive behavior disorders. PA girls may be more vulnerable to psychopathology than on-time adrenarche girls. The challenge of future studies is to determine which PA girls are at risk for psychopathology and which are more resilient.  (+info)

Morphological adrenarche in rhesus macaques: development of the zona reticularis is concurrent with fetal zone regression in the early neonatal period. (5/28)

 (+info)

Adrenal changes associated with adrenarche. (6/28)

 (+info)

Body composition in premature adrenarche by structural MRI, 1H MRS and DXA. (7/28)

BACKGROUND: Premature adrenarche (PA) is recognized to be a possible precursor of polycystic ovarian syndrome, type 2 diabetes mellitus and cardiovascular disease. Visceral adiposity and increased intramyocellular lipid (IMCL) are associated with insulin resistance and increased risk of cardiovascular disease. AIM: To determine whether prepubertal girls with PA have altered visceral adiposity and/or increased muscle lipid content compared to prepubertal girls without PA using proton magnetic resonance imaging (MRI) and spectroscopy (1H MRS). PATIENTS AND METHODS: We performed total body dual energy X-ray absorptiometry (DXA) scans, MRI of the trunk, and MRS of the tibialis anterior muscle in the right calf on six girls with PA and eight prepubertal controls. RESULTS: Amount of visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (SAT), and VAT to SAT ratio did not differ significantly between the PA and control girls. Those with PA, however, had significantly greater IMCL than controls (p = 0.004). CONCLUSIONS: This study adds further evidence that PA is not a benign condition, and future studies investigating early intervention with dietary and exercise counseling may help diminish potential risk for diabetes mellitus and/or cardiovascular disease.  (+info)

Utility of early insulin response and proinsulin to assess insulin resistance. (8/28)

 (+info)

Precocious puberty is a condition wherein children under the age of 8 or 9 experience early onset of pubertal changes, such as breast development, menstruation, or enlargement of the testes and scrotum. It is also known as central precocious puberty (CPP) when it is caused by premature activation of the hypothalamic-pituitary-gonadal axis, resulting in early release of sex hormones.

Precocious Puberty: Causes

The exact cause of precocious puberty is not known; however, several factors have been implicated, including:

1. Genetics: In some cases, precocious puberty may be inherited, with a family history of early puberty or other hormonal disorders.
2. Brain tumors: Tumors in the hypothalamus or pituitary gland can cause early activation of the HPG axis and result in precocious puberty.
3. Congenital anomalies: Some children may be born with abnormalities in the HPG axis, leading to early puberty.
4. Trauma: Traumatic brain injury or stroke may trigger premature activation of the HPG axis and result in precocious puberty.
5. Infections: Certain infections, such as meningitis or encephalitis, can cause inflammation in the hypothalamus or pituitary gland, leading to early puberty.
6. Nutritional factors: Malnutrition or rapid weight gain may contribute to early puberty.
7. Hormonal imbalance: Some children may have an imbalance of sex hormones, such as estrogen or testosterone, which can lead to early puberty.
8. Thyroid disorders: Hypothyroidism (underactive thyroid) or hyperthyroidism (overactive thyroid) can cause early puberty.
9. Chronic diseases: Certain chronic diseases, such as type 1 diabetes mellitus or inflammatory bowel disease, may increase the risk of early puberty.

It is important to note that in many cases, the exact cause of precocious puberty cannot be determined. If you suspect that your child is experiencing early puberty, it is essential to consult with a healthcare professional for proper evaluation and treatment.

In medicine, gigantism is typically diagnosed based on a combination of clinical features, including:

1. Excessive height: Gigantism is defined as a height that is two or more standard deviations above the mean for age and gender.
2. Proportional body size: The excessive height is accompanied by proportionate increases in other body dimensions, such as arm and leg length.
3. Obesity: Gigantism can also be associated with obesity, particularly in adults.
4. Coarsening of facial features: Individuals with gigantism may have a coarse or irregular appearance to their face, including a large jaw, prominent forehead, and heavy eyebrows.
5. Skin thickness: The skin may be thicker than normal, leading to a rough, scaly texture.
6. Skeletal abnormalities: Gigantism can be associated with skeletal abnormalities, such as bowed legs or a large head.
7. Endocrine disorders: Gigantism is often caused by an overproduction of growth hormone, which can be due to a benign tumor on the pituitary gland or another endocrine disorder.

Treatment for gigantism typically involves surgery to remove the tumor or other underlying cause of the condition. In some cases, medications may be used to reduce growth hormone production and slow down growth.

In summary, gigantism is a rare condition characterized by excessive height and proportional body size, often due to an overproduction of growth hormone. It can be associated with various physical features and endocrine disorders, and treatment typically involves surgery or medication to reduce growth hormone production.

... is the result of the development of a new zone of the adrenal cortex, the zona reticularis. Adrenarche is a process ... Adrenarche occurs in only a small number of primates, and only chimpanzees and gorillas show a pattern of adrenarche ... Levels of corticosteroids like cortisol do not change with adrenarche. Biological messengers during the onset of adrenarche are ... have an earlier onset of adrenarche, which raises the possibility that timing of adrenarche may be affected by physiological ...
... is a cutaneous condition seen typically in thin young women who report great psychological and ...
Functionally, adrenarche provides a source of androgens for the development of axillary and pubic hair before the beginning of ... Adrenarche is independent of ACTH or gonadotropins and correlates with a progressive thickening of the zona reticularis layer ... Hornsby, PJ (2012). "Adrenarche: a cell biological perspective". The Journal of Endocrinology. 214 (2): 113-119. doi:10.1530/ ... Rege, J; Rainey, WE (2012). "The steroid metabolome of adrenarche". The Journal of Endocrinology. 214 (2): 133-143. doi:10.1530 ...
Witchel, Selma Feldman; Topaloglu, A. Kemal (1 January 2019). "Chapter 17 - Puberty: Gonadarche and Adrenarche". Yen and ...
Auchus RJ, Rainey WE (March 2004). "Adrenarche - physiology, biochemistry and human disease". Clinical Endocrinology. 60 (3): ... Adrenal gland Adrenarche Ferriman-Gallwey score Hirsutism History of removal of leg and underarm hair in the United States ... driven by weak androgens produced by the adrenal in males and females during adrenarche, and testosterone from the testicle in ...
... should be contrasted with adrenarche. Gonadarche indicates that true central puberty has begun, while adrenarche is ...
One other case has shown premature adrenarche.[citation needed] Zach Samson (July 1, 2006). "Dr. Patterson, influential past ...
Adrenarche may be treated with hormone replacement therapy.[citation needed] PWS is commonly associated with development of ... This is manifested as undescended testes in males and benign premature adrenarche in females. Testes may descend with time or ...
It is hypothesized to be involved in adrenarche and adrenopause. The existence of this hormone is controversial and disputed ...
Premature adrenarche is the most common cause of premature pubarche. Early occurrences can arise due to congenital adrenal ... When adrenarche, central puberty, and all pathologic conditions have been excluded, the term isolated premature pubarche is ... First (and often transient) pubic hair resulting from adrenarche may appear between ages 10-12 at the beginning of puberty. ...
Patient history assessed includes age at thelarche, adrenarche, and menarche; patterns of menstruation; obesity; reproductive ...
... is preceded by adrenarche, marking an increase of adrenal androgen production between ages 6-10. Adrenarche is ... Regulation of adrenarche and its relationship to maturation of the hypothalamic-gonadal axis is not fully understood, and some ... Adrenal maturation, termed adrenarche, typically precedes gonadarche in mid-childhood. Neurokinin B (a tachykinin peptide) and ... The first androgenic hair resulting from adrenarche can be also transient and disappear before the onset of true puberty. The ...
Adrenarche Gonadarche Gynecomastia Menarche Pubarche De Silva, Nirupama K. (April 2018). "Breast development and disorders in ... adrenarche, pubarche, vaginal discharge, and bone growth, while the sole presence of early thelarche identifies premature ... Part III-Premature Thelarche and Premature Adrenarche. Variations of Normal?". The Endocrinologist. 11 (3): 196-203. doi: ...
While symptoms are usually diagnosed after puberty, children may present with premature adrenarche. Steroidogenic enzyme ...
While symptoms are usually diagnosed after puberty, children may present with premature adrenarche. The degree of hormonal ... September 2012). "Genetic defects in the cyp21a2 gene in heterozygous girls with premature adrenarche and adolescent females ...
The presence of pubic hair suggests GnRH insensitivity because normal adrenarche still occurs; in comparison, both adrenarche ...
Adrenarche is proposed as the endocrine mechanism underlying the reorganization of insecure attachment in middle childhood. ...
Implications for adrenarche and the polycystic ovary syndrome". Proceedings of the National Academy of Sciences. 92 (23): 10619 ...
... implications for adrenarche and the polycystic ovary syndrome". Proceedings of the National Academy of Sciences of the United ...
Adrenarche Adolescence and Emerging Adulthood: A Cultural Approach, Jeffrey Jensen Arnett, N.J.: Prentice-Hall, 3rd edition, ...
However, thelarche, adrenarche, and linear growth[clarification needed] can occur simultaneously and although uncommon, ... adrenarche) usually appears 2 years later. Onset of menstruation (menarche) is a late event (median 12.8 years), occurring ...
Circulating DHEAS (its sulfated ester) levels rise during adrenarche (≈7 years of age) while plasma testosterone levels are ...
In children aged 6 to 8 years old, there is a rise in androstenedione secretion along with DHEA during adrenarche. This rise in ...
Cushing's syndrome Cushing's disease Conn's syndrome Adrenocortical carcinoma Adrenarche Adrenopause "Embryology of the adrenal ...
... corresponding to physical changes seen during adrenarche and puberty. Early adolescents may become aware of their sexuality for ...
The bone age is often marginally advanced with premature adrenarche, when a child is overweight from a young age or when a ...
... associated with relatively early adrenarche) and traits associated with social anxiety. Children who experience early ...
They remain low during childhood until adrenarche around 6 to 8 years of age, at which point they markedly increase, eventually ...
... and testosterone of testicular origin that stops after this period until adrenarche. Girls do not experience this. Genetics and ...
... demonstrating the role of DHEA and other androgens in body hair development at both adrenarche and pubarche. DHEA is a weak ... are responsible for the androgenic effects of adrenarche, such as early pubic and axillary hair growth, adult-type body odor, ...
Premature adrenarche. Pubic hair development prior to thelarche or gonadarche. Age ,9 years for boys and ,8 years for girls. ...
Secretion of dehydroepiandrostenedione (DHEA) initiates adrenarche. In the United States, the average age of girls at menarche ... Adrenarche, sexual hair growth, is independent from GnRH function and typically occurs between breast budding and accelerated ...
Premature adrenarche. Saenger P, Dimartino-Nardi J. Saenger P, et al. J Endocrinol Invest. 2001 Oct;24(9):724-33. doi: 10.1007/ ... to estimate an overall pubertal factor and for each process of adrenarche and gonadarche. There were negative associations ... suggesting physical characteristics and hormones capture different aspects of neurobiological development during adrenarche. ...
Adrenarche, precocious 259.1. *Breast - see also condition*. buds 259.1*. in newborn 779.89. ...
MeSH Terms: Adrenal Glands/growth & development; Adrenal Glands/metabolism; Adrenarche/blood*; Androstenedione/blood; Breast/ ...
Premature Adrenarche. Premature Pubarche. Synonym: Premature Pubic Hair Growth. Primary Amenorrhea. Psychosis. Synonym: ...
Adrenal changes associated with adrenarche.. Nakamura Y; Gang HX; Suzuki T; Sasano H; Rainey WE. Rev Endocr Metab Disord; 2009 ...
Examples of maturational stages include infancy, adiposity rebound, adrenarche, puberty and growth cessation. This is in ...
9. Pubertal Maturation, Adrenarche, and the Onset of Reproduction in Human Males. Benjamin Campbell. ...
It also provides an overview of premature adrenarche, which is commonly diagnosed in children who have signs of precocious ...
Adrenarche Preferred Term Term UI T618284. Date11/17/2004. LexicalTag NON. ThesaurusID NLM (2006). ... Adrenarche Preferred Concept UI. M0475625. Scope Note. A stage of development at which the ADRENAL GLANDS undergo maturation ... Adrenarche usually begins at about 7 or 8 years of age before the signs of PUBERTY and continues throughout puberty.. Terms. ... Adrenarche usually begins at about 7 or 8 years of age before the signs of PUBERTY and continues throughout puberty.. Previous ...
During adrenarche, the adrenal glands, which sit on the kidneys, begin to churn out weak "male" hormones. That, in turn, can ...
Premature Adrenarche. Premature adrenarche is the early activation of the adrenal glands, resulting in the production of ... Premature adrenarche is often a benign condition but may be associated with an increased risk of developing PCOS or early ... Some common causes include congenital adrenal hyperplasia, early puberty, polycystic ovary syndrome, premature adrenarche, and ...
Adrenarche, and Sexual Maturation: A Longitudinal Test of a Life History Model) in the November/December issue of "Child ...
Adrenarche - Preferred Concept UI. M0475625. Scope note. A stage of development at which the ADRENAL GLANDS undergo maturation ... Adrenarche usually begins at about 7 or 8 years of age before the signs of PUBERTY and continues throughout puberty. ... Adrenarche usually begins at about 7 or 8 years of age before the signs of PUBERTY and continues throughout puberty.. ...
Adrenarche G8.686.785.880.374.204 G8.686.841.374.204 Adrenochrome D3.438.473.25 D3.633.100.473.25 Adrenocorticotropic Hormone ...
Adrenarche Preferred Term Term UI T618284. Date11/17/2004. LexicalTag NON. ThesaurusID NLM (2006). ... Adrenarche Preferred Concept UI. M0475625. Scope Note. A stage of development at which the ADRENAL GLANDS undergo maturation ... Adrenarche usually begins at about 7 or 8 years of age before the signs of PUBERTY and continues throughout puberty.. Terms. ... Adrenarche usually begins at about 7 or 8 years of age before the signs of PUBERTY and continues throughout puberty.. Previous ...
Female-dominant estrogen production in healthy young children before adrenarche. Endocr Connect. 2021 Sep 1:EC-21-0134.R1. doi ...
... adrenarche,noun,E0007484,yes phytohormonal,adj,E0335862,phytohormone,noun,E0047794,yes sub-zonal,adj,E0058759,sub-zone,noun, ...
Early adrenarche is known as "premature adrenarche." It is mostly idiopathic and of uncertain pathologic relevance but requires ... at the age of 6 to 8 years and reflects functional activation of the zona reticularis of the adrenal cortex at adrenarche, ...
C36285 C118464 Adverse Events Terminology C113337 Premature Adrenarche Premature Adrenarche Premature onset of adrenal androgen ...
Normal serum cortisol but ↑ cortisol production and excretion, early adrenarche, ↑ adrenal androgens and dehydroepiandrosterone ...
Premature Adrenarche (PA) * Premature Thelarche * Prematurity * Prenatal Drug Exposure * Prenatal Hydronephrosis * Primary ...
Circulating TNF-Alpha and IL-6 Concentrations and TNF-Alpha -308 G?,?A Polymorphism in Children with Premature Adrenarche. ...
Adrenarche in Silver-Russell Syndrome: Timing and Consequences Binder, Gerhard; Schweizer, Roland; Blumenstock, Gunnar; Ferrand ...
Premature adrenarche has been described as clinical and biochemical hyperandrogenism before the age of 8 years in girls and 9 ... Low prevalence of organic pathology in a predominantly black population with premature adrenarche: need to stratify definitions ...
Tytu orygina u: Adrenarche u 7-letniej dziewczynki z cz ciow trisomi 4q w kariotypie.. Tytu angielski: Adrenarche in 7 years ...
  • 9. 11-Ketotestosterone Is the Dominant Circulating Bioactive Androgen During Normal and Premature Adrenarche. (nih.gov)
  • This is called premature adrenarche. (aafp.org)
  • Premature adrenarche and normal puberty that starts too early often don't need treatment. (aafp.org)
  • It also provides an overview of premature adrenarche, which is commonly diagnosed in children who have signs of precocious puberty. (nih.gov)
  • Premature adrenarche is the early activation of the adrenal glands, resulting in the production of hormones that cause pubic hair growth. (mumeemagic.com)
  • Premature adrenarche is often a benign condition but may be associated with an increased risk of developing PCOS or early puberty later in childhood. (mumeemagic.com)
  • A Polymorphism in Children with Premature Adrenarche. (cdc.gov)
  • The existence of a relationship between adrenarche and puberty has been suggested, partly because increased concentrations of adrenal androgens in undertreated congenital adrenal hyperplasia have been associated with cases of true precocious puberty in boys. (nih.gov)
  • Serum androgens in normal prepubertal and pubertal children and in children with precocious adrenarche. (nih.gov)
  • 17. Serum androgens in normal prepubertal and pubertal children and in children with precocious adrenarche. (nih.gov)
  • Adrenarche may cause a transient acceleration of growth and serve as a permissive factor in male puberty but does not appear to be necessary for the initiation of puberty. (nih.gov)
  • Adrenarche usually begins at about 7 or 8 years of age before the signs of PUBERTY and continues throughout puberty. (nih.gov)
  • These hormonal changes, which constitute the adrenarche, are accompanied by the appearance of axillary and pubic hair and a transient acceleration of linear growth and bone maturation. (nih.gov)
  • Le tableau 1, presente en annexe, illustre la complexite d un systeme d assurance-maladie a deux etages (part obligatoire / half complementaire) et a plusieurs portes d entree (affliation par le travail ou par la residence en France) diabetes type 2 early warning signs [url=http://efgreatersil.org/buy-meds/Duetact/]17 mg duetact safe[/url]. (ehd.org)
  • 35% of the females present AOT, possible ZR cell number changes, and whether early adrenarche timing is different in Brazilian compared to European girls. (bioscientifica.com)
  • Bruce J. Ellis, an associate professor in the Norton School of Family and Consumer Sciences at the UA, and Marilyn J. Essex at Wisconsin, are reporting their research (Family Environments, Adrenarche, and Sexual Maturation: A Longitudinal Test of a Life History Model) in the November/December issue of "Child Development," the journal of the Society for Research in Child Development. (health.am)
  • Premature and exaggerated adrenarche can be indicative of future onset of adult diseases, thus increasing the clinical relevance of adrenarche. (medscape.com)
  • The aim of the study was to find out whether ACTH receptor (MC2R) promoter polymorphism associates with premature adrenarche (PA) and its characteristics. (nih.gov)
  • Polymorphism Pro12Ala of PPARG in prepubertal children with premature adrenarche and its association with growth in healthy children. (nih.gov)
  • Premature adrenarche and premature thelarche are two common, benign, normal variant conditions that can resemble true precocious puberty but that progress slowly or not at all. (medscape.com)
  • premature adrenarche refers to the appearance of pubic hair without other signs of puberty in girls or boys younger than 7-8 years. (medscape.com)
  • It also provides an overview of premature adrenarche, which is commonly diagnosed in children who have signs of precocious puberty. (nih.gov)
  • A Polymorphism in Children with Premature Adrenarche. (cdc.gov)
  • Adrenarche refers to the onset of dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) production from the adrenal zona reticularis that can be detected at around 6 years of age. (medscape.com)
  • However, the biochemical pathways that define adrenarche have been characterized in detail, and the appearance of key enzymes and cofactors in the adrenal zona reticularis track with the progression of adrenarche. (medscape.com)
  • This article reviews the clinical manifestations of adrenarche, the biochemistry of the enzymes involved in DHEA-S production, and the cell biology of the adrenal zona reticularis. (medscape.com)
  • The onset of DHEA-S production from the adrenal zona reticularis leads to the phenomenon of adrenarche. (medscape.com)
  • 1982). In order for adrenarche to occur, a specific cell type with the capacity to synthesize DHEA-S must arise within the adrenal glands. (medscape.com)
  • Our study provides evidence that the MC2R promoter polymorphism modulates the hypothalamo-pituitary-adrenal axis in children and may play a role in altered regulation of adrenarche. (nih.gov)
  • 19. Adrenal changes associated with adrenarche. (nih.gov)
  • The phenotypic result of adrenarche is pubarche or the development of axillary and pubic hair that occurs in both girls and boys at about age 8. (medscape.com)
  • Guran T, Firat I, Yildiz F, Bulut IK, Dogru M, Bereket A. Reference values for serum dehydroepiandrosterone sulfate in healthy children and adolescents with emphasis on the age of adrenarche and pubarche. (medscape.com)
  • The physiological triggers of adrenarche and the role(s) of DHEA-S remain speculative. (medscape.com)
  • Serum DHEA-S concentrations fall after birth then begins to increase around the age of 7-9 (adrenarche). (medscape.com)
  • Serum DHEA concentrations decrease after birth and then begin to increase at around age 7-9 years (adrenarche) and continue increasing until the third decade of life. (medscape.com)