Adrenarche: A stage of development at which the ADRENAL GLANDS undergo maturation leading to the capability of producing increasing amounts of adrenal androgens, DEHYDROEPIANDROSTERONE and ANDROSTENEDIONE. Adrenarche usually begins at about 7 or 8 years of age before the signs of PUBERTY and continues throughout puberty.Zona Reticularis: The inner zone of the adrenal cortex. This zone produces the enzymes that convert PREGNENOLONE, a 21-carbon steroid, to 19-carbon steroids (DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE) via 17-ALPHA-HYDROXYPREGNENOLONE.Puberty, Precocious: Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE.Progesterone Reductase: An enzyme that catalyzes the reduction of a 3 beta-hydroxy-delta(5)-steroid to 3-oxo-delta(4)-steroid in the presence of NAD. It converts pregnenolone to progesterone and dehydroepiandrosterone to androstenedione. EC 1.1.1.145.Gigantism: The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.Steroid 17-alpha-Hydroxylase: A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.Dehydroepiandrosterone Sulfate: The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.Etiocholanolone: The 5-beta-reduced isomer of ANDROSTERONE. Etiocholanolone is a major metabolite of TESTOSTERONE and ANDROSTENEDIONE in many mammalian species including humans. It is excreted in the URINE.Adrenal Cortex: The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.Steroid Metabolism, Inborn Errors: Errors in metabolic processing of STEROIDS resulting from inborn genetic mutations that are inherited or acquired in utero.Pan paniscus: The pygmy chimpanzee, a species of the genus Pan, family HOMINIDAE. Its common name is Bonobo, which was once considered a separate genus by some; others considered it a subspecies of PAN TROGLODYTES. Its range is confined to the forests of the central Zaire basin. Despite its name, it is often of equal size to P. troglodytes.Endocrinology: A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.Adrenal Glands: A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.Steroid 21-Hydroxylase: An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).Cytochromes b5: Cytochromes of the b group that are found bound to cytoplasmic side of ENDOPLASMIC RETICULUM. They serve as electron carrier proteins for a variety of membrane-bound OXYGENASES. They are reduced by the enzyme CYTOCHROME-B(5) REDUCTASE.Androgens: Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.17-alpha-Hydroxyprogesterone: A metabolite of PROGESTERONE with a hydroxyl group at the 17-alpha position. It serves as an intermediate in the biosynthesis of HYDROCORTISONE and GONADAL STEROID HORMONES.3-Hydroxysteroid Dehydrogenases: Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.Puberty: A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT.
(1/28) Cytochrome b(5) modulation of 17{alpha} hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis.

CYP17 is a steroidogenic enzyme located in the zona fasciculata and zona reticularis of the adrenal cortex and gonad tissues and which has dual functions - hydroxylation and as a lyase. The first activity gives hydroxylation of pregnenolone and progesterone at the C(17) position to generate 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone, while the second enzymic activity cleaves the C(17)-C(20) bond of 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone to form dehydroepiandro-sterone and androstenedione respectively. The modulation of these two activities occurs through cytochrome b(5). Association of cytochrome b(5) and CYP17 is thought to be based primarily on electrostatic interactions in which the negatively charged residues pair up with positively charged residues on the proximal surface of the CYP17 molecule. Non-specific interactions of the hydrophobic membrane regions of cytochrome b(5) and CYP17 are also thought to play a crucial role in the association of these two haemoproteins. Although cytochrome b(5) is known to stimulate CYP activity by contributing the second electron in the catalytic cycle, in the case of CYP17, the mechanism of cleavage stimulation proceeds via an allosteric mode. It is hypothesised that cytochrome b(5) promotes the cleavage by aligning the iron-oxygen complex attack onto the C(20) rather than the C(17) atom of the steroid substrate molecule. Thus, further understanding of the mechanism of modulation by cytochrome b(5) of the hydroxylase and lyase activities should shed new insights on developing therapeutic targets in CYP17-linked biochemical processes such as adrenarche, polycystic ovary syndrome and prostate cancer.  (+info)

(2/28) Early puberty-menarche after precocious pubarche: relation to prenatal growth.

OBJECTIVE: Girls with precocious pubarche (PP; pubic hair at <8 years of age) as a result of an early or amplified adrenarche (high dehydroepiandrosterone-sulfate [DHEAS]) tend to be hyperinsulinemic, in particular when born with low birth weight (LBW). The objective of this study was to assess the interrelationship among prenatal growth, PP, the timing of puberty-menarche, and adult stature. METHODS: We studied 187 PP girls longitudinally: (1) at birth, (2) in prepuberty, (3) at onset of puberty, (4) at menarche, and (5) on reaching adult stature. This PP cohort was divided into subgroups of higher birth weight (>0 SD), intermediate birth weight (0 to -2 SD), and lower birth weight (less than -2 SD). RESULTS: At the time of PP diagnosis, age, bone age, and BMI were similar across birth weight subgroups; circulating sex hormone-binding globulin and body height were reduced in PP girls with lower birth weight, and these remained so throughout pubertal development. Onset of puberty occurred earlier in PP girls with lower birth weight; so did menarche. Adult height differed by an average of 6.5 cm (approximately 1 SD) between the upper and lower birth weight subgroups; this difference was essentially achieved before puberty and even before PP. Menarche before age 12.0 years was twofold more prevalent in PP girls than in control subjects. Among PP girls, age at menarche was advanced by 8 to 10 months in lower versus higher birth weight girls. Menarche before age 12.0 years was threefold more prevalent among LBW-PP girls than in control subjects (approximately 75% vs approximately 25%). CONCLUSIONS: The link between prenatal growth restraint and early menarche is herewith extended to PP girls. In particular LBW-PP girls may become a target group for interventions directed toward normalization of pubertal onset and progression.  (+info)

(3/28) Adrenarche in the rat.

Normal pubertal development in humans involves two distinct processes: maturation of adrenal androgen secretion (adrenarche) and activation of the hypothalamic-pituitary-gonadal axis (gonadarche). One factor thought to contribute to the adrenarche in man is increased adrenal 17-hydroxylase (CYP17) activity. In the rat, there is evidence for adrenal involvement in the initiation of puberty, but the adrenal glands of this species are generally thought to express CYP17 only very poorly at best. To further examine the nature of postnatal adrenal development in rat, plasma samples and adrenal tissues were taken from animals aged 2-90 days, circulating adrenal steroids assayed, and adrenal zones assessed quantitatively. A relative increase in zona reticularis, and peaks of circulating cortisol, androstenedione, and 17-OH-progesterone were observed around postnatal days 16-20, clearly before the development of the gonads, which begins at 30-35 days. Quantitative reverse transcriptase PCR confirmed a peak in mRNA coding for CYP17 in adrenal tissue from rats of similar age. The results suggest that the rat adrenal has the capacity to secrete steroids arising from 17-hydroxylation, and that this may contribute to a process similar to human adrenarche.  (+info)

(4/28) Differences in endocrine parameters and psychopathology in girls with premature adrenarche versus on-time adrenarche.

Girls with premature adrenarche (PA) are at risk for multiple problems related to exaggerated androgen synthesis. Whether PA carries a risk of psychopathology remains unknown. This study examined group differences in: (a) anthropometric and endocrine parameters, and (b) mood and behavior problems, in 6-8 year-old girls with PA (n = 40) compared to on-time adrenarche girls (n = 36). PA girls were taller (p < or =0.05) and heavier (p < or =0.01) than the on-time adrenarche girls but body mass index showed no difference. PA girls had significantly (p <0.05) higher adrenal androgen and testosterone concentrations but not cortisol or leptin. PA girls also had significantly more oppositional defiant disorder, and higher symptom counts reflecting anxiety, mood or disruptive behavior disorders. PA girls may be more vulnerable to psychopathology than on-time adrenarche girls. The challenge of future studies is to determine which PA girls are at risk for psychopathology and which are more resilient.  (+info)

(5/28) Morphological adrenarche in rhesus macaques: development of the zona reticularis is concurrent with fetal zone regression in the early neonatal period.

 (+info)

(6/28) Adrenal changes associated with adrenarche.

 (+info)

(7/28) Body composition in premature adrenarche by structural MRI, 1H MRS and DXA.

BACKGROUND: Premature adrenarche (PA) is recognized to be a possible precursor of polycystic ovarian syndrome, type 2 diabetes mellitus and cardiovascular disease. Visceral adiposity and increased intramyocellular lipid (IMCL) are associated with insulin resistance and increased risk of cardiovascular disease. AIM: To determine whether prepubertal girls with PA have altered visceral adiposity and/or increased muscle lipid content compared to prepubertal girls without PA using proton magnetic resonance imaging (MRI) and spectroscopy (1H MRS). PATIENTS AND METHODS: We performed total body dual energy X-ray absorptiometry (DXA) scans, MRI of the trunk, and MRS of the tibialis anterior muscle in the right calf on six girls with PA and eight prepubertal controls. RESULTS: Amount of visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (SAT), and VAT to SAT ratio did not differ significantly between the PA and control girls. Those with PA, however, had significantly greater IMCL than controls (p = 0.004). CONCLUSIONS: This study adds further evidence that PA is not a benign condition, and future studies investigating early intervention with dietary and exercise counseling may help diminish potential risk for diabetes mellitus and/or cardiovascular disease.  (+info)

(8/28) Utility of early insulin response and proinsulin to assess insulin resistance.

 (+info)

*  Puberty
... is preceded by adrenarche, marking an increase of adrenal androgen production between ages 6-10. Adrenarche is ... Adrenal maturation, termed adrenarche, typically precedes gonadarche in mid-childhood. Neurokinin B (a tachykinin peptide) and ... The first androgenic hair resulting from adrenarche can be also transient and disappear before the onset of true puberty. The ... Rising levels of adrenal androgens (termed adrenarche) can usually be detected between 6 and 11 years of age, even before the ...
*  Adrenarche
... is the result of the development of a new zone of the adrenal cortex, the zona reticularis. Adrenarche is a process ... Adrenarche occurs in only a small number of primates, and only chimpanzees and gorillas show a pattern of adrenarche ... have an earlier onset of adrenarche, which raises the possibility that timing of adrenarche may be affected by physiological ... "Differences in Endocrine Parameters and Psychopathology in Girls with Premature Adrenarche versus On-time Adrenarche". J ...
*  Persistent adrenarche syndrome
... (also known as "Adrenal SAHA syndrome") is a cutaneous condition seen typically in thin young ...
*  Adrenal gland
Functionally, adrenarche provides a source of androgens for the development of axillary and pubic hair before the beginning of ... Adrenarche is independent of ACTH or gonadotropins and correlates with a progressive thickening of the zona reticularis layer ... Hornsby, PJ (2012). "Adrenarche: a cell biological perspective". The Journal of Endocrinology. 214 (2): 113-119. doi:10.1530/ ... Rege, J; Rainey, WE (2012). "The steroid metabolome of adrenarche". The Journal of Endocrinology. 214 (2): 133-143. doi:10.1530 ...
*  Underarm hair
Puberty Adrenarche Adrenal gland Tanner staging Hirsutism Ferriman-Gallwey score Auchus, Richard J.; Rainey, William E. (2004- ... driven by weak androgens produced by the adrenal in males and females during adrenarche, and testosterone from the testicle in ... 03-01). "Adrenarche - physiology, biochemistry and human disease". Clinical Endocrinology. 60 (3): 288-296. doi:10.1046/j.1365- ... usually coinciding with onset of adrenarche) Wolfsdorf Stage 3- coarse axillary hair, less than full-adult Wolfsdorf Stage 4- ...
*  Gonadarche
... should be contrasted with adrenarche. Gonadarche indicates that true central puberty has begun, while adrenarche is ...
*  Patterson syndrome
One other case has shown premature adrenarche. Zach Samson (July 1, 2006). "Dr. Patterson, influential past president of AAP ...
*  Thelarche
Adrenarche Gonadarche Menarche Pubarche Isolated Premature Thelarche Dictionary.com > thelarche Citing: The American Heritage® ...
*  Pubarche
When adrenarche, central puberty, and all pathologic conditions have been excluded, the term isolated premature pubarche is ... Premature adrenarche is the most common cause of premature pubarche. Rarer causes include precocious puberty, congenital ... First (and often transient) pubic hair resulting from adrenarche may appear between ages 6-10 well preceding puberty. During ... The average age for females varies between 9-12, and for males, about 10-12.[citation needed] Adrenarche Androgens Menarche ...
*  Walter L. Miller (endocrinologist)
Implications for adrenarche and the polycystic ovary syndrome". Proceedings of the National Academy of Sciences. 92 (23): 10619 ...
*  CYP17A1
... implications for adrenarche and the polycystic ovary syndrome". Proceedings of the National Academy of Sciences of the United ...
*  Spermarche
Adrenarche Adolescence and Emerging Adulthood: A Cultural Approach, Jeffrey Jensen Arnett, N.J.: Prentice-Hall, 3rd edition, ...
*  Müllerian agenesis
... the person will enter puberty with development of secondary sexual characteristics including thelarche and adrenarche (pubic ...
*  Xenoestrogen
However, thelarche, adrenarche, and linear growth[clarification needed] can occur simultaneously and although uncommon, ... adrenarche) usually appears 2 years later. Onset of menstruation (menarche) is a late event (median 12.8 years), occurring ...
*  Androstenedione
In children aged 6 to 8 years old, there is a rise in androstenedione secretion along with DHEA during adrenarche. This rise in ...
*  Bone age
The bone age is often marginally advanced with premature adrenarche, when a child is overweight from a young age or when a ...
*  Pituitary gland
... associated with relatively early adrenarche) and traits associated with social anxiety. Children who experience early ...
*  Dehydroepiandrosterone sulfate
They remain low during childhood until adrenarche around 6 to 8 years of age, at which point they markedly increase, eventually ...
*  Dehydroepiandrosterone
... are responsible for the androgenic effects of adrenarche, such as early pubic and axillary hair growth, adult-type body odor, ... and other androgens in body hair development at both adrenarche and pubarche. As a neurosteroid and neurotrophin, DHEA has ...
*  Finasteride
In a study of 89 women with hyperandrogenism due to persistent adrenarche syndrome, finasteride produced a 93% reduction in ...
*  List of syndromes
... pharyngitis and adenitis Perisylvian syndrome Perlman syndrome Persistent adrenarche syndrome Persistent genital arousal ...
*  Immunology
... bone age in normal boys and girls and in patients with Addison's disease or hypogonadism or with premature or late adrenarche ...
*  Congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency
... or from simple premature adrenarche because of the DHEA elevation. Some of the childhood management issues are similar those of ...
*  Progesterone
... and is also produced in smaller amounts by the adrenal glands after the onset of adrenarche in both males and females. To a ...
*  Isolated 17,20-lyase deficiency
... or fully absent adrenarche and puberty with an associated reduction in or complete lack of development of secondary sexual ...
Premature Adrenarche Treatments | Boston Childrens Hospital  Premature Adrenarche Treatments | Boston Children's Hospital
Learn more about Premature Adrenarche treatments from experts at Boston Children's, ranked best Children's Hospital by US News. ... Treatments for Premature Adrenarche in Children. Premature adrenarche doesn't require treatment. However, it will cause your ...
more infohttp://www.childrenshospital.org/conditions-and-treatments/conditions/p/premature-adrenarche/treatments
5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activity in prepubertal Hispanic girls with premature adrenarche. -...  5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activity in prepubertal Hispanic girls with premature adrenarche. -...
Total cortisol metabolites were not different in the girls with premature adrenarche, compared with the controls. In conclusion ... in prepubertal Hispanic girls with premature adrenarche, compared with controls. Therefore, in this group of young girls, ... total 11 oxo/total 11 hydroxy metabolites in 24-h urine samples from 17 prepubertal Hispanic girls with premature adrenarche ... in the 5 alpha-reductase or 11 beta-hydroxysteroid dehydrogenase activities in the prepubertal girls with premature adrenarche ...
more infohttps://www.semanticscholar.org/paper/5-alpha-reductase-and-11-beta-hydroxysteroid-dehyd-Silfen-Shackleton/018ab3c0f96b12a4e7dcaa84e3ff157db6899159
Adrenarche - Wikipedia  Adrenarche - Wikipedia
Adrenarche is the result of the development of a new zone of the adrenal cortex, the zona reticularis. Adrenarche is a process ... Adrenarche occurs in only a small number of primates, and only chimpanzees and gorillas show a pattern of adrenarche ... have an earlier onset of adrenarche, which raises the possibility that timing of adrenarche may be affected by physiological ... "Differences in Endocrine Parameters and Psychopathology in Girls with Premature Adrenarche versus On-time Adrenarche". J ...
more infohttps://en.wikipedia.org/wiki/Adrenarche
Persistent adrenarche syndrome - Wikipedia  Persistent adrenarche syndrome - Wikipedia
Persistent adrenarche syndrome (also known as "Adrenal SAHA syndrome") is a cutaneous condition seen typically in thin young ...
more infohttps://en.wikipedia.org/wiki/Persistent_adrenarche_syndrome
Testing & Diagnosis for Premature Adrenarche | Boston Childrens Hospital  Testing & Diagnosis for Premature Adrenarche | Boston Children's Hospital
Learn more about Premature Adrenarche testing and diagnosis from experts at Boston Children's, ranked best Children's Hospital ... How is premature adrenarche diagnosed? If your child is showing symptoms of premature adrenarche, her healthcare provider may ... Testing & Diagnosis for Premature Adrenarche in Children. Tests ...
more infohttp://www.childrenshospital.org/conditions-and-treatments/conditions/p/premature-adrenarche/testing-and-diagnosis
Associations between body mass, leptin, IGF-I and circulating adrenal androgens in children with obesity and premature...  Associations between body mass, leptin, IGF-I and circulating adrenal androgens in children with obesity and premature...
We also tested whether these parameters contribute to inducing premature adrenarche (PA).. DESIGN: In a cross-sectional study, ... We also tested whether these parameters contribute to inducing premature adrenarche (PA).. DESIGN: In a cross-sectional study, ... IGF-I and circulating adrenal androgens in children with obesity and premature adrenarche. European Journal of Endocrinology, ... IGF-I and circulating adrenal androgens in children with obesity and premature adrenarche ...
more infohttp://www.zora.uzh.ch/id/eprint/111630/
Metabolic and hormonal assessment of adolescent and young adult women with prior premature adrenarche
							| Clinics
			  Metabolic and hormonal assessment of adolescent and young adult women with prior premature adrenarche | Clinics
Premature adrenarche - a common condition with variable presentation.. Horm Res Paediatr 83((4)), 221-31. ... Premature adrenarche - normal variant or forerunner of adult disease?.. Endocr Rev 21((6)), 671-96. ... The molecular basis of premature adrenarche: an hypothesis.. Acta Paediatr Suppl 88((433)), 60-6. ... Metabolic and hormonal assessment of adolescent and young adult women with prior premature adrenarche * Flávia Alves Ribeiro ...
more infohttp://www.revistas.usp.br/clinics/article/view/159387
Clinical Phenotype of Patients with MCM4 Mutation Suggests Pubertal Delay in Males in Addition to Adrenal Failure, Absent...  Clinical Phenotype of Patients with MCM4 Mutation Suggests Pubertal Delay in Males in Addition to Adrenal Failure, Absent...
Clinically all children ,8 years have absent adrenarche. Renin and aldosterone levels were normal. Children had low birth ... Absent Adrenarche, and Short Stature in Boys and Girls. Claire Hughesa,b, Adrian Clarkb, Louise Metherellb & Colm Costigana. ... Absent Adrenarche, and Short Stature in Boys and Girls (. ...
more infohttp://abstracts.eurospe.org/hrp/0082/hrp0082fc1.2.htm
Supplementary Material for: Adrenarche and Puberty in Children with Classic Congenital Adrenal Hyperplasia due to 21...  Supplementary Material for: Adrenarche and Puberty in Children with Classic Congenital Adrenal Hyperplasia due to 21...
Adrenarche and Puberty in Children with Classic Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency ... Supplementary Material for: Adrenarche and Puberty in Children with Classic Congenital Adrenal Hyperplasia due to 21- ... There have been only a few studies on adrenarche in girls with classic congenital adrenal hyperplasia (CAH) showing that ... Conclusions: Pubarche and adrenarche are dissociated in classic CAH: earlier pubarche, gonadarche and thelarche, respectively, ...
more infohttps://karger.figshare.com/articles/Supplementary_Material_for_Adrenarche_and_Puberty_in_Children_with_Classic_Congenital_Adrenal_Hyperplasia_due_to_21-Hydroxylase_Deficiency/5122978/1
Evaluation and Referral of Children With Signs of Early Puberty | From the American Academy of Pediatrics | Pediatrics  Evaluation and Referral of Children With Signs of Early Puberty | From the American Academy of Pediatrics | Pediatrics
Premature Adrenarche. Adrenarche, an adrenal maturational event associated with an increase in secretion of DHEA and its more ... premature adrenarche. PCP - primary care physician. PROS - Pediatric Research in Office Settings Network. PT - premature ... The most common of these signs of early puberty are premature adrenarche (early onset of pubic hair and/or body odor), ... In children with premature adrenarche, bone age advancement by 2 or more years is common and generally benign. J Pediatr ...
more infohttp://pediatrics.aappublications.org/content/early/2015/12/11/peds.2015-3732
Medical Issues A-Z  Medical Issues A-Z
Adrenarche. "Adrenarche" is the term for the development of sexual hair - underarms, genital, and facial hair. In childhood, ... See Adrenarche for another hormone finding which is not the result of the previously described abnormalities. ...
more infohttps://www.pwsausa.org/medical-issues-a-z/
Pediatrics Help - Forums and Discussions - MedHelp  - Page 5  Pediatrics Help - Forums and Discussions - MedHelp - Page 5
2 yr old daughter(preemie) with premature adrenarche(extreme body odor) and 1 year advanced bone age. Hormone levels normal ...
more infohttps://www.medhelp.org/forums/Pediatrics/show/153?page=5
Adrenal gland - Wikipedia  Adrenal gland - Wikipedia
AdrenarcheEdit. Main article: Adrenarche. During early childhood androgen synthesis and secretion remain low, but several years ... Adrenarche is independent of ACTH or gonadotropins and correlates with a progressive thickening of the zona reticularis layer ... Functionally, adrenarche provides a source of androgens for the development of axillary and pubic hair before the beginning of ... These changes are part of a process called adrenarche, which has only been described in humans and some other primates. ...
more infohttps://en.m.wikipedia.org/wiki/Adrenal_gland
Tips From Other Journals - American Family Physician  Tips From Other Journals - American Family Physician
This finding alters the previous definition of premature adrenarche, which has been defined as the growth of pubic hair in ... Characteristics of Benign Premature Adrenarche. Sparse to moderate development of pubic hair ... Characteristics of Benign Premature Adrenarche. Sparse to moderate development of pubic hair ...
more infohttps://www.aafp.org/afp/2000/0915/p1406.html
Male Tanner Stage  Male Tanner Stage
Sexual Development Female Tanner Stage Pubertal Delay Precocious Puberty Precocious Puberty Causes Benign Premature Adrenarche ... Stage: Tanner 3 (Adrenarche) *Height increases at accelerated rate: 7-8 cm/year ...
more infohttps://fpnotebook.com/endo/Exam/MlTnrStg.htm
Link Between Body Fat and the Timing of Puberty | SUPPLEMENT ARTICLES | Pediatrics  Link Between Body Fat and the Timing of Puberty | SUPPLEMENT ARTICLES | Pediatrics
Remer T, Manz F. Role of nutritional status in the regulation of adrenarche. J Clin Endocrinol Metab.1999;84(11) :3936- 3944. ... A preliminary study of 7 US girls with premature adrenarche and 8 age-matched control subjects showed a higher BMI and a ... Human Studies That Link Leptin, Puberty, Adrenarche, and Body Fat. As the role of leptin in rodent physiology was being ... Charkaluk ML, Trivin C, Brauner R. Premature pubarche as an indicator of how body weight influences the onset of adrenarche. ...
more infohttp://pediatrics.aappublications.org/content/121/Supplement_3/S208
Endocrinology Flashcards by  | Brainscape  Endocrinology Flashcards by | Brainscape
At 4-5 yo, girls w/ premature adrenarche, clitoromeg, acne, rapid growth, hirsut, infert. Boys = premature adrenarche, rapid ...
more infohttps://www.brainscape.com/flashcards/endocrinology-2366453/packs/4155556
Endocrinology - Reproductive Endocrinology Flashcards by Josh Davies | Brainscape  Endocrinology - Reproductive Endocrinology Flashcards by Josh Davies | Brainscape
Adrenarche refers to the time during puberty when the adrenal glands increase their production and secretion of adrenal ... However, the signs of adrenarche, such as pubic hair, axillary hair, acne, and body odor do not typically occur until early ... such as benign premature thelarche and benign premature adrenarche. ...
more infohttps://www.brainscape.com/flashcards/endocrinology-reproductive-endocrinology-5678820/packs/7933764
  • OBJECTIVE: Follow-up studies of girls with premature adrenarche have reported the development of polycystic ovary syndrome, insulin resistance, and dyslipidemia and a propensity to cardiovascular disease. (usp.br)
  • In children aged 6 to 8 years old, there is a rise in androstenedione secretion along with DHEA during adrenarche. (wikipedia.org)
  • Adrenarche also occurs prematurely in many children who are overweight, suggesting a possible relationship with body mass or adiposity signals. (wikipedia.org)
  • As mentioned above, premature adrenarche occurs more often in children with intrauterine growth retardation and in overweight children. (wikipedia.org)
  • Third, at least one report found an increased incidence of behavior and school problems in a group of children with premature adrenarche compared with an otherwise similar control group. (wikipedia.org)