Adrenarche
A stage of development at which the ADRENAL GLANDS undergo maturation leading to the capability of producing increasing amounts of adrenal androgens, DEHYDROEPIANDROSTERONE and ANDROSTENEDIONE. Adrenarche usually begins at about 7 or 8 years of age before the signs of PUBERTY and continues throughout puberty.
Zona Reticularis
Puberty, Precocious
Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE.
Progesterone Reductase
Gigantism
The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.
Steroid 17-alpha-Hydroxylase
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
Dehydroepiandrosterone Sulfate
Etiocholanolone
Adrenal Cortex
The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.
Steroid Metabolism, Inborn Errors
Pan paniscus
The pygmy chimpanzee, a species of the genus Pan, family HOMINIDAE. Its common name is Bonobo, which was once considered a separate genus by some; others considered it a subspecies of PAN TROGLODYTES. Its range is confined to the forests of the central Zaire basin. Despite its name, it is often of equal size to P. troglodytes.
Endocrinology
Dehydroepiandrosterone
A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
Adrenal Glands
Steroid 21-Hydroxylase
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Cytochromes b5
Androgens
Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.
17-alpha-Hydroxyprogesterone
Puberty
A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT.
Receptors, Mineralocorticoid
Mineralocorticoids
A group of CORTICOSTEROIDS primarily associated with water and electrolyte balance. This is accomplished through the effect on ION TRANSPORT in renal tubules, resulting in retention of sodium and loss of potassium. Mineralocorticoid secretion is itself regulated by PLASMA VOLUME, serum potassium, and ANGIOTENSIN II.
Carbohydrate Metabolism
Leptin
Receptors, Leptin
Body Mass Index
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
Body Height
Receptors, Androgen
Polychlorinated Biphenyls
Contraceptives, Oral
Pediatrics
Puberty, Delayed
The lack of development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations above the mean age at onset of PUBERTY in a population. Delayed puberty can be classified by defects in the hypothalamic LHRH pulse generator, the PITUITARY GLAND, or the GONADS. These patients will undergo spontaneous but delayed puberty whereas patients with SEXUAL INFANTILISM will not.
Lipoprotein(a)
A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.
Polycystic Ovary Syndrome
A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.
Testosterone
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Encyclopedias as Topic
Endocytosis
Cholesterol
Cholesterol Esters
Lipoproteins, LDL
A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.
Sulfotransferases
Addison Disease
An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.
Cytochrome b(5) modulation of 17{alpha} hydroxylase and 17-20 lyase (CYP17) activities in steroidogenesis. (1/28)
CYP17 is a steroidogenic enzyme located in the zona fasciculata and zona reticularis of the adrenal cortex and gonad tissues and which has dual functions - hydroxylation and as a lyase. The first activity gives hydroxylation of pregnenolone and progesterone at the C(17) position to generate 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone, while the second enzymic activity cleaves the C(17)-C(20) bond of 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone to form dehydroepiandro-sterone and androstenedione respectively. The modulation of these two activities occurs through cytochrome b(5). Association of cytochrome b(5) and CYP17 is thought to be based primarily on electrostatic interactions in which the negatively charged residues pair up with positively charged residues on the proximal surface of the CYP17 molecule. Non-specific interactions of the hydrophobic membrane regions of cytochrome b(5) and CYP17 are also thought to play a crucial role in the association of these two haemoproteins. Although cytochrome b(5) is known to stimulate CYP activity by contributing the second electron in the catalytic cycle, in the case of CYP17, the mechanism of cleavage stimulation proceeds via an allosteric mode. It is hypothesised that cytochrome b(5) promotes the cleavage by aligning the iron-oxygen complex attack onto the C(20) rather than the C(17) atom of the steroid substrate molecule. Thus, further understanding of the mechanism of modulation by cytochrome b(5) of the hydroxylase and lyase activities should shed new insights on developing therapeutic targets in CYP17-linked biochemical processes such as adrenarche, polycystic ovary syndrome and prostate cancer. (+info)Early puberty-menarche after precocious pubarche: relation to prenatal growth. (2/28)
OBJECTIVE: Girls with precocious pubarche (PP; pubic hair at <8 years of age) as a result of an early or amplified adrenarche (high dehydroepiandrosterone-sulfate [DHEAS]) tend to be hyperinsulinemic, in particular when born with low birth weight (LBW). The objective of this study was to assess the interrelationship among prenatal growth, PP, the timing of puberty-menarche, and adult stature. METHODS: We studied 187 PP girls longitudinally: (1) at birth, (2) in prepuberty, (3) at onset of puberty, (4) at menarche, and (5) on reaching adult stature. This PP cohort was divided into subgroups of higher birth weight (>0 SD), intermediate birth weight (0 to -2 SD), and lower birth weight (less than -2 SD). RESULTS: At the time of PP diagnosis, age, bone age, and BMI were similar across birth weight subgroups; circulating sex hormone-binding globulin and body height were reduced in PP girls with lower birth weight, and these remained so throughout pubertal development. Onset of puberty occurred earlier in PP girls with lower birth weight; so did menarche. Adult height differed by an average of 6.5 cm (approximately 1 SD) between the upper and lower birth weight subgroups; this difference was essentially achieved before puberty and even before PP. Menarche before age 12.0 years was twofold more prevalent in PP girls than in control subjects. Among PP girls, age at menarche was advanced by 8 to 10 months in lower versus higher birth weight girls. Menarche before age 12.0 years was threefold more prevalent among LBW-PP girls than in control subjects (approximately 75% vs approximately 25%). CONCLUSIONS: The link between prenatal growth restraint and early menarche is herewith extended to PP girls. In particular LBW-PP girls may become a target group for interventions directed toward normalization of pubertal onset and progression. (+info)Adrenarche in the rat. (3/28)
Normal pubertal development in humans involves two distinct processes: maturation of adrenal androgen secretion (adrenarche) and activation of the hypothalamic-pituitary-gonadal axis (gonadarche). One factor thought to contribute to the adrenarche in man is increased adrenal 17-hydroxylase (CYP17) activity. In the rat, there is evidence for adrenal involvement in the initiation of puberty, but the adrenal glands of this species are generally thought to express CYP17 only very poorly at best. To further examine the nature of postnatal adrenal development in rat, plasma samples and adrenal tissues were taken from animals aged 2-90 days, circulating adrenal steroids assayed, and adrenal zones assessed quantitatively. A relative increase in zona reticularis, and peaks of circulating cortisol, androstenedione, and 17-OH-progesterone were observed around postnatal days 16-20, clearly before the development of the gonads, which begins at 30-35 days. Quantitative reverse transcriptase PCR confirmed a peak in mRNA coding for CYP17 in adrenal tissue from rats of similar age. The results suggest that the rat adrenal has the capacity to secrete steroids arising from 17-hydroxylation, and that this may contribute to a process similar to human adrenarche. (+info)Differences in endocrine parameters and psychopathology in girls with premature adrenarche versus on-time adrenarche. (4/28)
Girls with premature adrenarche (PA) are at risk for multiple problems related to exaggerated androgen synthesis. Whether PA carries a risk of psychopathology remains unknown. This study examined group differences in: (a) anthropometric and endocrine parameters, and (b) mood and behavior problems, in 6-8 year-old girls with PA (n = 40) compared to on-time adrenarche girls (n = 36). PA girls were taller (p < or =0.05) and heavier (p < or =0.01) than the on-time adrenarche girls but body mass index showed no difference. PA girls had significantly (p <0.05) higher adrenal androgen and testosterone concentrations but not cortisol or leptin. PA girls also had significantly more oppositional defiant disorder, and higher symptom counts reflecting anxiety, mood or disruptive behavior disorders. PA girls may be more vulnerable to psychopathology than on-time adrenarche girls. The challenge of future studies is to determine which PA girls are at risk for psychopathology and which are more resilient. (+info)Morphological adrenarche in rhesus macaques: development of the zona reticularis is concurrent with fetal zone regression in the early neonatal period. (5/28)
(+info)Adrenal changes associated with adrenarche. (6/28)
(+info)Body composition in premature adrenarche by structural MRI, 1H MRS and DXA. (7/28)
BACKGROUND: Premature adrenarche (PA) is recognized to be a possible precursor of polycystic ovarian syndrome, type 2 diabetes mellitus and cardiovascular disease. Visceral adiposity and increased intramyocellular lipid (IMCL) are associated with insulin resistance and increased risk of cardiovascular disease. AIM: To determine whether prepubertal girls with PA have altered visceral adiposity and/or increased muscle lipid content compared to prepubertal girls without PA using proton magnetic resonance imaging (MRI) and spectroscopy (1H MRS). PATIENTS AND METHODS: We performed total body dual energy X-ray absorptiometry (DXA) scans, MRI of the trunk, and MRS of the tibialis anterior muscle in the right calf on six girls with PA and eight prepubertal controls. RESULTS: Amount of visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (SAT), and VAT to SAT ratio did not differ significantly between the PA and control girls. Those with PA, however, had significantly greater IMCL than controls (p = 0.004). CONCLUSIONS: This study adds further evidence that PA is not a benign condition, and future studies investigating early intervention with dietary and exercise counseling may help diminish potential risk for diabetes mellitus and/or cardiovascular disease. (+info)Utility of early insulin response and proinsulin to assess insulin resistance. (8/28)
(+info)
5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activity in prepubertal Hispanic girls with premature adrenarche. -...
Premature Adrenarche Treatments | Boston Childrens Hospital
The timing of the onset of adrenarche in Pakistani boys | ICEECE2012
Microsoft word - review. normal and premature adrenarche. manuscript alicia belgorosky.doc
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Adrenarche
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Adrenarche: Physiology, Biochemistry and Human Disease
Adrenarche: Physiology, Biochemistry and Human Disease
Deletion in the uridine diphosphate glucuronyltransferase 2B17 gene is associated with delayed pubarche in healthy boys in:...
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Adrenal gland
AdrenarcheEdit. Main article: Adrenarche. During early childhood androgen synthesis and secretion remain low, but several years ... Adrenarche is independent of ACTH or gonadotropins and correlates with a progressive thickening of the zona reticularis layer ... Functionally, adrenarche provides a source of androgens for the development of axillary and pubic hair before the beginning of ... These changes are part of a process called adrenarche, which has only been described in humans and some other primates. ...
Adrenal gland
Functionally, adrenarche provides a source of androgens for the development of axillary and pubic hair before the beginning of ... Adrenarche is independent of ACTH or gonadotropins and correlates with a progressive thickening of the zona reticularis layer ... Hornsby, PJ (2012). "Adrenarche: a cell biological perspective". The Journal of Endocrinology. 214 (2): 113-119. doi:10.1530/ ... Rege, J; Rainey, WE (2012). "The steroid metabolome of adrenarche". The Journal of Endocrinology. 214 (2): 133-143. doi:10.1530 ...
XX male syndrome
Witchel, Selma Feldman; Topaloglu, A. Kemal (1 January 2019). "Chapter 17 - Puberty: Gonadarche and Adrenarche". Yen and ...
Underarm hair
Adrenal gland Adrenarche Ferriman-Gallwey score Hirsutism Puberty Tanner staging Auchus, Richard J.; Rainey, William E. (1 ... driven by weak androgens produced by the adrenal in males and females during adrenarche, and testosterone from the testicle in ... usually coinciding with onset of adrenarche) Wolfsdorf Stage 3- coarse axillary hair, less than full-adult Wolfsdorf Stage 4- ... March 2004). "Adrenarche - physiology, biochemistry and human disease". Clinical Endocrinology. 60 (3): 288-296. doi:10.1046/j. ...
Gonadarche
... should be contrasted with adrenarche. Gonadarche indicates that true central puberty has begun, while adrenarche is ...
Patterson syndrome
One other case has shown premature adrenarche.[citation needed] Zach Samson (July 1, 2006). "Dr. Patterson, influential past ...
Prader-Willi syndrome
Adrenarche may be treated with hormone replacement therapy. PWS is commonly associated with development of strabismus. In one ... This is manifested as undescended testes in males and benign premature adrenarche in females. Testes may descend with time or ...
Pubarche
Premature adrenarche is the most common cause of premature pubarche. Early occurrences can arise due to congenital adrenal ... When adrenarche, central puberty, and all pathologic conditions have been excluded, the term isolated premature pubarche is ... The average age for females varies between 12 and 14, and for males, about 13-15.[citation needed] Adrenarche Androgens ... First (and often transient) pubic hair resulting from adrenarche may appear between ages 10-12 preceding puberty. During ...
Puberty
... is preceded by adrenarche, marking an increase of adrenal androgen production between ages 6-10. Adrenarche is ... Adrenal maturation, termed adrenarche, typically precedes gonadarche in mid-childhood. Neurokinin B (a tachykinin peptide) and ... The first androgenic hair resulting from adrenarche can be also transient and disappear before the onset of true puberty. The ... Rising levels of adrenal androgens (termed adrenarche) can usually be detected between 6 and 11 years of age, even before the ...
Thelarche
Adrenarche Gonadarche Gynecomastia Menarche Pubarche De Silva, Nirupama K. (April 2018). "Breast development and disorders in ... adrenarche, pubarche, vaginal discharge, and bone growth, while premature thelarche is identified by the sole presence of early ... Part III-Premature Thelarche and Premature Adrenarche. Variations of Normal?". The Endocrinologist. 11 (3): 196-203. doi: ...
21-Hydroxylase
While symptoms are usually diagnosed after puberty, children may present with premature adrenarche. Steroidogenic enzyme ...
Late onset congenital adrenal hyperplasia
While symptoms are usually diagnosed after puberty, children may present with premature adrenarche. The degree of hormonal ... September 2012). "Genetic defects in the cyp21a2 gene in heterozygous girls with premature adrenarche and adolescent females ...
Gonadotropin-releasing hormone insensitivity
The presence of pubic hair suggests GnRH insensitivity because normal adrenarche still occurs; in comparison, both adrenarche ...
Attachment theory
Adrenarche is proposed as the endocrine mechanism underlying the reorganization of insecure attachment in middle childhood. ...
Walter L. Miller (endocrinologist)
Implications for adrenarche and the polycystic ovary syndrome". Proceedings of the National Academy of Sciences. 92 (23): 10619 ...
CYP17A1
... implications for adrenarche and the polycystic ovary syndrome". Proceedings of the National Academy of Sciences of the United ...
Spermarche
Adrenarche Adolescence and Emerging Adulthood: A Cultural Approach, Jeffrey Jensen Arnett, N.J.: Prentice-Hall, 3rd edition, ...
Xenoestrogen
However, thelarche, adrenarche, and linear growth[clarification needed] can occur simultaneously and although uncommon, ... adrenarche) usually appears 2 years later. Onset of menstruation (menarche) is a late event (median 12.8 years), occurring ...
Aggression
Circulating DHEAS (its sulfated ester) levels rise during adrenarche (≈7 years of age) while plasma testosterone levels are ...
Androstenedione
In children aged 6 to 8 years old, there is a rise in androstenedione secretion along with DHEA during adrenarche. This rise in ...
Adrenal cortex
Cushing's syndrome Cushing's disease Conn's syndrome Adrenocortical carcinoma Adrenarche Adrenopause "Embryology of the adrenal ...
Bone age
The bone age is often marginally advanced with premature adrenarche, when a child is overweight from a young age or when a ...
Pituitary gland
... associated with relatively early adrenarche) and traits associated with social anxiety. Children who experience early ...
Dehydroepiandrosterone sulfate
They remain low during childhood until adrenarche around 6 to 8 years of age, at which point they markedly increase, eventually ...
Infantile acne
... and testosterone of testicular origin that stops after this period until adrenarche. Girls do not experience this. Genetics and ...
Dehydroepiandrosterone
... demonstrating the role of DHEA and other androgens in body hair development at both adrenarche and pubarche. DHEA is a weak ... are responsible for the androgenic effects of adrenarche, such as early pubic and axillary hair growth, adult-type body odor, ...
List of skin conditions
Myxedema Panhypopituitarism Persistent adrenarche syndrome (adrenal SAHA syndrome) Polycystic ovarian syndrome Seborrhoea-acne- ...
Finasteride
In a study of 89 women with hyperandrogenism due to persistent adrenarche syndrome, finasteride produced a 93% reduction in ...
List of syndromes
... pharyngitis and adenitis Perisylvian syndrome Perlman syndrome Persistent adrenarche syndrome Persistent genital arousal ...
Adrenarche - Wikipedia
Adrenarche is the result of the development of a new zone of the adrenal cortex, the zona reticularis. Adrenarche is a process ... Adrenarche occurs in only a small number of primates, and only chimpanzees and gorillas show a pattern of adrenarche ... Levels of corticosteroids like cortisol do not change with adrenarche. An initiator of adrenarche has not yet been identified. ... have an earlier onset of adrenarche, which raises the possibility that timing of adrenarche may be affected by physiological ...
Adrenarche: Physiology, Biochemistry and Human Disease
At adrenarche, the expression of CPR increases in all zones of the adrenal, which should increase both activities of the CYP17 ... At adrenarche, the zona reticularis begins to expand, and 3βHSD2 content falls, restricting steroidogenesis to the Δ5-pathway. ... Adrenarche and Steroidogenesis. CYP11A performs the first committed step common to all cells that synthesize steroid hormones: ... As adrenarche progresses, the expanding zona reticularis expresses high amounts of b 5 (Fig. 2). ...
Adrenarche: Physiology, Biochemistry and Human Disease
The onset of DHEA-S production from the adrenal zona reticularis leads to the phenomenon of adrenarche. Adrenarche occurs only ... The phenomenon of adrenarche is unique to human beings and to some Old World primates, and a reversal of adrenarche appears to ... thus increasing the clinical relevance of adrenarche. The physiological triggers of adrenarche and the role(s) of DHEA-S remain ... Adrenarche refers to the onset of dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) production from the adrenal zona ...
Persistent adrenarche syndrome - Wikipedia
Adrenarche
... refers to a stage of maturation of the cortex of the human adrenal glands. It typically occurs between ... Premature adrenarche. Premature adrenarche is the most common cause of the early appearance of pubic hair ("premature pubarche ... Role of adrenarche as part of puberty. An initiator of adrenarche has not yet been identified. Researchers have unsuccessfully ... Structural and functional changes of adrenarche. Structural changes of adrenarche include increased size and mass of the ...
Premature Adrenarche: Information for Parents - HealthyChildren.org
Does premature adrenarche cause any harm to the child?. There are generally no health problems caused by PA. Girls with PA may ... Premature adrenarche (PA) is one of the most common diagnoses made in children referred to a specialist for signs of early ... Treatment for premature adrenarche. There is no treatment that will cause the pubic and/or underarm hair to go away. ... What else besides premature adrenarche can cause early pubic hair?. A small percentage of children with PA may be found to have ...
Premature Adrenarche Treatments | Boston Children's Hospital
Testing & Diagnosis for Premature Adrenarche | Boston Children's Hospital
Learn more about Premature Adrenarche testing and diagnosis from experts at Boston Childrens, ranked best Childrens Hospital ... How is premature adrenarche diagnosed? If your child is showing symptoms of premature adrenarche, her healthcare provider may ... Testing & Diagnosis for Premature Adrenarche in Children. Tests ...
The timing of the onset of adrenarche in Pakistani boys | ICEECE2012
Adrenarche is a normal maturational event that in humans occurs at around 6 8 years of age. During adrenarche, a new zone of ... and DHEAS and T at adrenarche. We report here that the age of adrenarche in Pakistani boys is 7 years. ... The timing of the onset of adrenarche in Pakistani boys. F. Bibi1, A. Naseem1, S. Aslam2, M. Irfan1, F. Tahir3, M. Qayyum1, R. ... The present study was aimed at unraveling the age of the onset of adrenarche in Pakistani boys. The history of the boys of 1 10 ...
Serum anti-mullerian hormone is elevated in girls with exaggerated adrenarche | SFEBES2007
Serum anti-mullerian hormone is elevated in girls with exaggerated adrenarche. WF Paterson1, R Fleming2, SF Ahmed1 & AM Wallace ... r=−0.264) and between AMH and DHAS (r=−0.372) in the girls with adrenarche. Interestingly, the AMH concentration in the ... Median AMH in the girls with exaggerated adrenarche was 15.1 pmol/L, significantly higher than found in 5 8 year-old girls who ... Serum AMH (pmol/L) was measured by immunoassay (DSL Elisa) in 25 girls with clinical signs of exaggerated adrenarche [median ( ...
Associations between body mass, leptin, IGF-I and circulating adrenal androgens in children with obesity and premature...
We also tested whether these parameters contribute to inducing premature adrenarche (PA).. DESIGN: In a cross-sectional study, ... We also tested whether these parameters contribute to inducing premature adrenarche (PA).. DESIGN: In a cross-sectional study, ... IGF-I and circulating adrenal androgens in children with obesity and premature adrenarche. European Journal of Endocrinology, ... IGF-I and circulating adrenal androgens in children with obesity and premature adrenarche ...
The Urinary Steroid Signature of Premature Adrenarche | ESPE2019
... of adrenarche is just appearing earlier in girls with premature adrenarche or earlier and different compared to adrenarche at ... Background: Adrenarche describes the developmental event of the human adrenal cortex when the zona reticularis increases the ... Results: Girls with premature adrenarche were heavier (median weight 26.2±4.5 kg) than controls (21.5±3.4 kg) and had a higher ... The Urinary Steroid Signature of Premature Adrenarche. Marco Janner1, Grit Sommer1, Michael Groessl1, Christa Flück2. ...
Changes in carotid artery sonogram in premature adrenarche - Fingerprint
- UC Davis
Evaluation and Referral of Children With Signs of Early Puberty | From the American Academy of Pediatrics | Pediatrics
Premature Adrenarche. Adrenarche, an adrenal maturational event associated with an increase in secretion of DHEA and its more ... premature adrenarche. PCP - primary care physician. PROS - Pediatric Research in Office Settings Network. PT - premature ... The most common of these signs of early puberty are premature adrenarche (early onset of pubic hair and/or body odor), ... In children with premature adrenarche, bone age advancement by 2 or more years is common and generally benign. J Pediatr ...
Follow-up of Growth and Puberty in Girls and Boys with Premature Adrenarche | ESPE2016
Background: Premature adrenarche (PA) has been linked with early pubertal development, but only few longitudinal studies on PA ... Follow-up of Growth and Puberty in Girls and Boys with Premature Adrenarche. Jani Liimattaa, Pauliina Utriainenc, Raimo ... Follow-up of Growth and Puberty in Girls and Boys with Premature Adrenarche (. ...
HORMONE-BEHAVIOR RELATIONS IN ADRENARCHE
- Penn State
children with premature adrenarche and on-time adrenarche. (Adrenarche refers to maturation of the adrenal glands and an ... time adrenarche. The relations of serum to saliva hormones and the relation of hormones and behavior will be examined with ... adrenarche, and (4) use the data to conduct power analyses to determine the required sample size. Subjects include: 6-9 year ... evaluation of premature adrenarche (n = 12) and a matched comparison group of healthy children (n = 20). Measures include: ...
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Depression, immune function, and early adrenarche in children
Lipoprotein(a) levels in girls with premature adrenarche. | PubFacts
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Adrenal gland - Wikipedia
AdrenarcheEdit. Main article: Adrenarche. During early childhood androgen synthesis and secretion remain low, but several years ... Adrenarche is independent of ACTH or gonadotropins and correlates with a progressive thickening of the zona reticularis layer ... Functionally, adrenarche provides a source of androgens for the development of axillary and pubic hair before the beginning of ... These changes are part of a process called adrenarche, which has only been described in humans and some other primates. ...
Microsoft word - review. normal and premature adrenarche. manuscript alicia belgorosky.doc
normal and premature adrenarche. manuscript alicia belgorosky.doc. NORMAL AND PREMATURE ADRENARCHE Alicia Belgorosky; María ... The mechanism behind precocious adrenarche is as intriguing as that behind normal adrenarche. From a cel ular perspective, ... However, many questions remain with incomplete answers, such as, 1) the mechanisms of adrenarche and premature adrenarche, 2) ... 3. Premature adrenarche. ONE-YEAR-OLD ADRENAL GLAND cell proliferation Aldosterone z. glomerulosa Cortisol Androstenedione z. ...
Genetic variation of FTO and TCF7L2 in premature adrenarche. - PubMed - NCBI
Tips From Other Journals - American Family Physician
This finding alters the previous definition of premature adrenarche, which has been defined as the growth of pubic hair in ... Characteristics of Benign Premature Adrenarche. Sparse to moderate development of pubic hair ... Characteristics of Benign Premature Adrenarche. Sparse to moderate development of pubic hair ...
Low prevalence of organic pathology in a predominantly black population with premature adrenarche: need to stratify definitions...
... premature adrenarche. Premature adrenarche is more common among black girls compared to white girls and other racial groups. ... Two hundred and seventy three subjects had signs of early adrenarche. Three subjects were found to have CAH (2 with NCCAH and 1 ... Few studies have been done to evaluate a largely black population with premature adrenarche to assess the incidence of adrenal ... Adrenal pathology such as NCCAH is less common as a cause for premature adrenarche compared with idiopathic premature ...
Link Between Body Fat and the Timing of Puberty | SUPPLEMENT ARTICLES | Pediatrics
Remer T, Manz F. Role of nutritional status in the regulation of adrenarche. J Clin Endocrinol Metab.1999;84(11) :3936- 3944. ... A preliminary study of 7 US girls with premature adrenarche and 8 age-matched control subjects showed a higher BMI and a ... Human Studies That Link Leptin, Puberty, Adrenarche, and Body Fat. As the role of leptin in rodent physiology was being ... Charkaluk ML, Trivin C, Brauner R. Premature pubarche as an indicator of how body weight influences the onset of adrenarche. ...
Depression, immune function, and early adrenarche in children | Foundation for Vertebral Subluxation
Faustina M. Delany, Michelle L. Byrne, Sarah Whittle, Julian G. Simmons, Craig Olsson, Lisa K. Mundy, George C. Patton, Nicholas B. Allen Psychoneuroendocrinology. 5 October 2015. Pages 228-234 Abstract Despite consistent findings of an association between depression and immunity in adult and adolescent populations, little is known about the nature of this relationship at earlier…
Male Tanner Stage
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Metabolic and hormonal assessment of adolescent and young adult women with prior premature adrenarche
| Clinics
Premature adrenarche - a common condition with variable presentation.. Horm Res Paediatr 83((4)), 221-31. ... Premature adrenarche - normal variant or forerunner of adult disease?.. Endocr Rev 21((6)), 671-96. ... The molecular basis of premature adrenarche: an hypothesis.. Acta Paediatr Suppl 88((433)), 60-6. ... Metabolic and hormonal assessment of adolescent and young adult women with prior premature adrenarche * Flávia Alves Ribeiro ...
PubertyPubarcheThelarcheBody odorZona reticularisMaturationOccursAppearance of pubic hairAndrogensGonadarcheOnset of adrenarcheIncrease in adrenal androgenCongenital adrenal hypHormonalSecretionPhysiologicalDHEASOccurGirls with clinical signsAdvanced developmentalAndrostenedioneFuture onsetSyndromeDevelopmentDHASMetabolitesBiosynthesisSteroidogenesisYearsSerumIncreasesChildrenHormonesTriggersPrepubertal
Puberty20
- Adrenarche is a process related to puberty, but distinct from hypothalamic-pituitary-gonadal axis (HPG axis) maturation and function. (wikipedia.org)
- Adrenarche begins on average between age 5 to 8 in girls and between 7 to 11 in boys, and precedes puberty by about 2 years. (wikipedia.org)
- In girls, the adrenal androgens of adrenarche produce most of the early androgenic changes of puberty: pubic hair, body odor, skin oiliness, and acne. (wikipedia.org)
- citation needed] However, the independence of adrenarche and gonadal puberty is apparent in children with atypical or abnormal development, when one process may occur without the other. (wikipedia.org)
- For instance, adrenarche does not occur in many girls with Addison's disease, who will continue to have minimal pubic hair as puberty progresses. (wikipedia.org)
- Conversely, girls with Turner syndrome will have normal adrenarche and normal pubic hair development, but true gonadal puberty never occurs because their ovaries are defective. (wikipedia.org)
- First, when pubic hair appears at an unusually early age in a child, premature adrenarche should be distinguished from true central precocious puberty, from congenital adrenal hyperplasia, and from androgen-producing tumors of the adrenals or gonads. (wikipedia.org)
- Premature adrenarche (PA) is one of the most common diagnoses made in children referred to a specialist for signs of early puberty. (healthychildren.org)
- The most common of these signs of early puberty are premature adrenarche (early onset of pubic hair and/or body odor), premature thelarche (nonprogressive breast development, usually occurring before 2 years of age), and lipomastia, in which girls have apparent breast development which, on careful palpation, is determined to be adipose tissue. (aappublications.org)
- Timing of adrenarche, the first phase of puberty that occurs during late childhood, is a plausible moderator of the depression-immunity relationship in late childhood due to its associations with both the immune system and psychological wellbeing. (edu.au)
- Adrenarche can be considered as the puberty of the adrenal gland, but the two processes (adrenal and gonadal puberty) are independent. (health-articles.net)
- However, androgens of adrenal origin had been postulated to be able to initiate activation of the hypothalamic-pituitary-gonadal axis, because central precocious puberty often occurs in children untreated or poorly treated for congenital adrenal hyperplasia (1,15,32), suggesting a possible relationship between adrenarche and gonadarche.On the contrary, the adrenal insufficiency does not represent a limiting factor for the development of gonadarche (33). (health-articles.net)
- However, dissociation between pubarche and biochemical markers of adrenarche can occur in girls with precocious puberty, who have pubarche long before adrenarche (34-35). (health-articles.net)
- opposite situation has been reported in some girls with Turner syndrome, mainly in those with premature ovarian failure Premature adrenarche, the early increase in adrenal androgen production might be associated with ovarian hyperandrogenism and polycystic ovarian syndrome in females, as wel as with insulin resistance in the two sexes, during puberty development, adult life and even in childhood (15,18, 36-42). (health-articles.net)
- Some children develop isolated and idiopathic premature adrenarche (PA), which is defined as the onset of androgenic signs before 8 years of age in girls and 9 years of age in boys, in the absence of true puberty, steroidogenic enzymatic defects and virilizing tumors. (usp.br)
- Another important component of puberty is adrenarche, which is the release of hormones from the adrenal gland. (healio.com)
- Differentiate premature thelarche and adrenarche from true precocious puberty. (slideshare.net)
- Due to the earlier onset of puberty in recent times, some experts have recommended that these guidelines be changed to thelarche prior to age 7 in White girls and prior to age 6 in African-Americans and adrenarche prior to age 8 years. (oncologynurseadvisor.com)
- This period follows adrenarche by about two years and is what most people think of as puberty. (flashcardmachine.com)
- Incomplete forms of precocious puberty include premature thelarche (unilateral or bilateral), premature pubarche and premature adrenarche with appearance of pubic and axillary hair. (contemporaryobgyn.net)
Pubarche7
- Premature adrenarche is the most common cause of the early appearance of pubic hair ("premature pubarche") in childhood. (wikipedia.org)
- The phenotypic result of adrenarche is pubarche or the development of axillary and pubic hair that occurs in both girls and boys at about age 8. (medscape.com)
- Pubarche has often been taken as the clinical sign of adrenarche, therefore, the terms adrenarche and pubarche have been usual y used as synonyms (15,33). (health-articles.net)
- Pubarche and adrenarche are dissociated in classic CAH: earlier pubarche, gonadarche and thelarche, respectively, in both sexes contrast with the absence of typical adrenarche. (figshare.com)
- We aimed to obtain normative data on dehydroepiandrosterone-sulphate (DHEA-S) secretion in healthy children and to evaluate the age of adrenarche, pubarche and the DHEA-S levels at which pubarche starts in both sexes. (marmara.edu.tr)
- The term adrenarche is often used interchangeably with pubarche, as the main clinical sign of adrenarche is pubic hair growth. (oncologynurseadvisor.com)
- These terms include premature thelarche, premature adrenarche, premature pubarche and premature menarche. (rarediseases.org)
Thelarche2
- Classically, early development was considered thelarche prior to age 8 years or adrenarche prior to age 9 years. (oncologynurseadvisor.com)
- SEP measures were examined for associations with pubertal onset, assessed by breast budding (thelarche) and pubic hair development (adrenarche). (aacrjournals.org)
Body odor4
- Adrenarche is an early stage in sexual maturation that happens in some higher primates and in humans, typically peaks at around 20 years of age, and is eventually involved in the development of pubic hair, body odor, skin oiliness, and acne. (wikipedia.org)
- The principal physical consequences of adrenarche are androgen effects, especially pubic hair (in which Tanner stage 2 becomes Tanner stage 3) and the change of sweat composition that produces adult body odor. (wikipedia.org)
- 2 yr old daughter(preemie) with premature adrenarche(extreme body odor) and 1 year advanced bone age. (medhelp.org)
- Sometimes body odor can be the first sign of something called premature adrenarche, when glands are stimulated and cause growth of pubertal hair under the arms and in the genital area at an early age. (everydayhealth.com)
Zona reticularis8
- Adrenarche is the result of the development of a new zone of the adrenal cortex, the zona reticularis. (wikipedia.org)
- Adrenarche refers to the onset of dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) production from the adrenal zona reticularis that can be detected at around 6 years of age. (medscape.com)
- However, the biochemical pathways that define adrenarche have been characterized in detail, and the appearance of key enzymes and cofactors in the adrenal zona reticularis track with the progression of adrenarche. (medscape.com)
- This article reviews the clinical manifestations of adrenarche, the biochemistry of the enzymes involved in DHEA-S production, and the cell biology of the adrenal zona reticularis. (medscape.com)
- The onset of DHEA-S production from the adrenal zona reticularis leads to the phenomenon of adrenarche. (medscape.com)
- Adrenarche describes the developmental event of the human adrenal cortex when the zona reticularis increases the synthesis of C19 steroids (DHEA/-S) markedly at around 6-8 years of age. (eurospe.org)
- Adrenarche occurs only in higher primates, typical y at 6-8 y of age in humans, when the innermost layer of adrenal cortex, the zona reticularis, develops. (health-articles.net)
- In addition, the regulation of adrenal steroidogenesis in zona reticularis is a complex process, since adrenarche requires both the acquisition of 17, 20-lyase activity of P450c17 and a decrease of 3beta HSD expression (18-20,22-27). (health-articles.net)
Maturation2
- Adrenarche refers to a stage of maturation of the cortex of the human adrenal glands . (bionity.com)
- Adrenarche refers to maturation of the adrenal glands and an increase in its hormones which occurs normally, at ages 6 to 8). (elsevier.com)
Occurs6
- Adrenarche occurs between the ages of 6 and 20 years. (wikipedia.org)
- Adrenarche also occurs prematurely in many children who are overweight, suggesting a possible relationship with body mass or adiposity signals. (wikipedia.org)
- As mentioned above, premature adrenarche occurs more often in children with intrauterine growth retardation and in overweight children. (wikipedia.org)
- Adrenarche occurs only in human beings and some Old World primates, such as the chimpanzee (Smail et al . (medscape.com)
- Adrenarche is a normal maturational event that in humans occurs at around 6 8 years of age. (endocrine-abstracts.org)
- Adrenarche occurs when a child's adrenal glands start producing the steroid DHEA. (ucsf.edu)
Appearance of pubic hair1
- Girls with idiopathic premature adrenarche, characterized by the early appearance of pubic hair and adrenal hyperandrogenism, may be at an increased risk for polycystic ovarian syndrome and its associated complications. (semanticscholar.org)
Androgens6
- During adrenarche the adrenal glands secrete increased levels of weak adrenal androgens, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione (A4), but without increased cortisol levels. (wikipedia.org)
- 39 steroid metabolites comprising progesterones, corticosterones, aldosterone, androgens, estrogens and glucocorticoids were measured in the urine by gas chromatography mass spectrometry in 23 girls with premature adrenarche (age range 3.9-8.4 years) and 22 healthy, age-matched controls (4.3-8.5 years). (eurospe.org)
- Girls with premature adrenarche produce more androgens than healthy girls of the same age. (eurospe.org)
- It is important to note that pubic hair in girls and adult axillary odor in boys and girls is related to the increase in secretion of weak adrenal androgens (primarily dehydroepiandrosterone-sulfate [DHEA-S]), referred to as adrenarche, and is unrelated to activation of the HPG axis. (aappublications.org)
- Even though adrenarche might be a multifactorial event, the main process regulating the production of adrenal androgens continues to represent one of the most intriguing mysteries in adrenal functional differentiation. (health-articles.net)
- Levels of adrenal androgens (dehydroepiandrosterone [DHEA] and dehydroepiandrosterone sulfate [DHEA-S]) are usually elevated in boys and girls with premature adrenarche. (medscape.com)
Gonadarche1
- In general adrenarche is independent of gonadarche. (oncologynurseadvisor.com)
Onset of adrenarche2
- Many children born small for gestational age (SGA) because of intrauterine growth restriction (IUGR) have an earlier onset of adrenarche, which raises the possibility that timing of adrenarche may be affected by physiological programming in infancy. (wikipedia.org)
- The present study was aimed at unraveling the age of the onset of adrenarche in Pakistani boys. (endocrine-abstracts.org)
Increase in adrenal androgen1
- Technically, adrenarche refers to the age-dependent increase in adrenal androgen precursor production around age 6-7 years. (oncologynurseadvisor.com)
Congenital adrenal hyp2
- There have been only a few studies on adrenarche in girls with classic congenital adrenal hyperplasia (CAH) showing that dehydroepiandrosterone sulfate (DHEAS) levels did not rise at the physiological age of adrenarche. (figshare.com)
- Is basal serum 17-OH progesterone a reliable parameter to predict nonclassical congenital adrenal hyperplasia in premature adrenarche? (acibadem.edu.tr)
Hormonal3
- The girls with premature adrenarche (PA) were shown to share similar hormonal/metabolic properties with PCOS. (pubfacts.com)
- The hormonal response to ACTH was evaluated in 17 girls with clinical signs of premature adrenarche and 17 adolescent females with hyperandrogenemia, along with direct DNA sequencing and MLPA analysis for mutations in the CYP21A2 gene. (cdc.gov)
- Miller has a longstanding interest in a hormonal and developmental phenomenon known to pediatricians as premature adrenarche. (ucsf.edu)
Secretion2
- Premature adrenarche gonadotropin secretion. (wellchild.org)
- In children aged 6 to 8 years old, there is a rise in androstenedione secretion along with DHEA during adrenarche. (wikipedia.org)
Physiological1
- The physiological triggers of adrenarche and the role(s) of DHEA-S remain speculative. (medscape.com)
DHEAS2
- We observed strong positive correlations between androsteindione and DHEAS, androsteindione and T, and DHEAS and T at adrenarche. (endocrine-abstracts.org)
- Even thought the importance of the fetal production of DHEA and DHEAS is related to their role as substrates for the massive rise in estrogens biosynthesis during gestation (29), the significance of adrenarche in human physiology remains unknown. (health-articles.net)
Occur3
- At adrenarche, the expression of CPR increases in all zones of the adrenal, which should increase both activities of the CYP17 enzyme system, particularly 17,20-lyase activity, thus boosting the overall capacity to produce DHEA-S. Therefore, robust adrenal CPR expression is necessary for adrenal DHEA-S production, but increases in CPR content alone are not sufficient to explain the biochemical changes in the reticularis that occur during of adrenarche. (medscape.com)
- The phenomenon of adrenarche is unique to human beings and to some Old World primates, and a reversal of adrenarche appears to occur in the ageing process. (medscape.com)
- 1982). In order for adrenarche to occur, a specific cell type with the capacity to synthesize DHEA-S must arise within the adrenal glands. (medscape.com)
Girls with clinical signs1
- Serum AMH (pmol/L) was measured by immunoassay (DSL Elisa) in 25 girls with clinical signs of exaggerated adrenarche [median (range) age 8.1 (6.0 8.9) years] recruited into a Scottish multicentre adrenarche study. (endocrine-abstracts.org)
Advanced developmental1
- The early rise in AMH in girls with exaggerated adrenarche implies that follicular development has proceeded to more advanced developmental stages than normal. (endocrine-abstracts.org)
Androstenedione1
- A characteristic aspect of early adrenarche is a diminished activity of 3β-hydroxysteroid dehydrogenase, the enzyme which mediates the hydroxylation of 17-hydroxypregnenolone to 17-hydroxyprogesterone , and DHEA to androstenedione . (bionity.com)
Future onset2
- Premature and exaggerated adrenarche can be indicative of future onset of adult diseases, thus increasing the clinical relevance of adrenarche. (medscape.com)
- The premature and/or exaggerated adrenarche results in future onset of diseases and thus has a clinical relevance. (endocrine-abstracts.org)
Syndrome3
- Persistent adrenarche syndrome is a cutaneous condition seen typically in thin young women who report great psychological and physical stress in their lives. (wikipedia.org)
- Early appearance of this event is called premature adrenarche (PA) and has been associated with adverse outcomes including polycystic ovary syndrome and metabolic syndrome. (eurospe.org)
- OBJECTIVE: Follow-up studies of girls with premature adrenarche have reported the development of polycystic ovary syndrome, insulin resistance, and dyslipidemia and a propensity to cardiovascular disease. (usp.br)
Development4
- Background: Premature adrenarche (PA) has been linked with early pubertal development, but only few longitudinal studies on PA girls and boys born appropriate for gestational age (AGA) have been reported. (eurospe.org)
- Adrenarche" is the term for the development of sexual hair - underarms, genital, and facial hair. (pwsausa.org)
- The fact that adrenarche is confined to higher-order primates indicates that this phenomenon is a relatively recent evolutionary development. (health-articles.net)
- I am currently designing a study among the Ju'Hoansi of Namibia to test the impact of nutritional status on the timing of adrenarche and its implications for development. (uwm.edu)
DHAS1
- r =−0.264) and between AMH and DHAS ( r =−0.372) in the girls with adrenarche. (endocrine-abstracts.org)
Metabolites5
- This study aimed at characterizing the urinary steroid metabolome of girls with premature adrenarche in comparison to healthy controls with a special focus on metabolites originating of novel, alternate androgen pathways. (eurospe.org)
- The urinary steroid signature of adrenarche includes steroid metabolites of alternate pathways, which shows differences in premature adrenarche. (eurospe.org)
- However, in contrast to the latter proposal, adrenarche might begin earlier in childhood, as suggested by studies performed in healthy children measuring DHEA, as wel as the DHEA metabolites in 24-h urine samples (16). (health-articles.net)
- We studied C19 and C21 urinary steroid metabolites, 5 alpha/5 beta and 11 oxo/11 hydroxy metabolite pairs as well as the ratios of the total 5 alpha/total 5 beta and total 11 oxo/total 11 hydroxy metabolites in 24-h urine samples from 17 prepubertal Hispanic girls with premature adrenarche and seven controls. (semanticscholar.org)
- Total cortisol metabolites were not different in the girls with premature adrenarche, compared with the controls. (semanticscholar.org)
Biosynthesis1
- Although CYP11A is essential for DHEA-S biosynthesis and for adrenarche, all steroid hormone production requires CYP11A as well. (medscape.com)
Steroidogenesis1
- 2000). However, as CYP11A (with StAR) is the quantitative regulator of steroidogenesis, alterations in CYP11A activities may contribute to the genesis of premature and/or exaggerated adrenarche. (medscape.com)
Years2
- We report here that the age of adrenarche in Pakistani boys is 7 years. (endocrine-abstracts.org)
- This finding alters the previous definition of premature adrenarche, which has been defined as the growth of pubic hair in girls younger than eight years and in boys younger than nine years. (aafp.org)
Serum2
- In view of the reported association between adrenarche and functional ovarian hyperandrogenism, we measured serum AMH in girls with exaggerated adrenarche and compared them with normative data. (endocrine-abstracts.org)
- The cross sectional pilot study proposed here, will be conducted in preparation for the longitudinal study to: (1) test the feasibility of using the biological and psychological measures, (2) determine the correlation between serum and saliva hormones, (3) identify a trend for hormone-behavior relations to exist in adrenarche, and (4) use the data to conduct power analyses to determine the required sample size. (elsevier.com)
Increases1
- Heterozygosity for CYP21A2 mutations in females increases their risk of clinically manifesting hyperandrogenism and the present study was designed to seek evidence on the prevalence and consequences of heterozygous CYP21A2 mutations in children with premature adrenarche and adolescents with hyperandrogenemia. (cdc.gov)
Children4
- Is testing needed in children with premature adrenarche? (healthychildren.org)
- The purpose of the proposal is to examine change in adrenal hormones at adrenarche and how these changes relate to moods, health, and behavior in children with premature adrenarche and on-time adrenarche. (elsevier.com)
- Subjects include: 6-9 year old children seen for evaluation of premature adrenarche (n = 12) and a matched comparison group of healthy children (n = 20). (elsevier.com)
- We hypothesized that: (1) a depression-immunity association exists in children, (2) this association is moderated by adrenarche. (edu.au)
Hormones1
- It is normal for production of these hormones to increase (something we call adrenarche) and for pubic hair to appear after age 8 in girls or 9 in boys. (healthychildren.org)
Triggers1
- In boys, adrenarche also triggers penile enlargement and voice changes. (healio.com)
Prepubertal3
- 5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activity in prepubertal Hispanic girls with premature adrenarche. (semanticscholar.org)
- We found no differences in the 5 alpha-reductase or 11 beta-hydroxysteroid dehydrogenase activities in the prepubertal girls with premature adrenarche, compared with the controls. (semanticscholar.org)
- In conclusion, we did not demonstrate a difference in the peripheral steroid metabolism, specifically 5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activities, in prepubertal Hispanic girls with premature adrenarche, compared with controls. (semanticscholar.org)