Adrenal Rest Tumor: Neoplasm derived from displaced cells (rest cells) of the primordial ADRENAL GLANDS, generally in patients with CONGENITAL ADRENAL HYPERPLASIA. Adrenal rest tumors have been identified in TESTES; LIVER; and other tissues. They are dependent on ADRENOCORTICOTROPIN for growth and adrenal steroid secretion.Fludrocortisone: A synthetic mineralocorticoid with anti-inflammatory activity.Adrenal Hyperplasia, Congenital: A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.Digestive System Fistula: An abnormal passage communicating between any components of the digestive system, or between any part of the digestive system and surrounding organ(s).Facial NeoplasmsDehydroepiandrosterone Sulfate: The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.Marsupialia: An infraclass of MAMMALS, also called Metatheria, where the young are born at an early stage of development and continue to develop in a pouch (marsupium). In contrast to Eutheria (placentals), marsupials have an incomplete PLACENTA.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.Tasmania: An island south of Australia and the smallest state of the Commonwealth. Its capital is Hobart. It was discovered and named Van Diemen's Island in 1642 by Abel Tasman, a Dutch navigator, in honor of the Dutch governor-general of the Dutch East Indian colonies. It was renamed for the discoverer in 1853. In 1803 it was taken over by Great Britain and was used as a penal colony. It was granted government in 1856 and federated as a state in 1901. (From Webster's New Geographical Dictionary, 1988, p1190 & Room, Brewer's Dictionary of Names, p535)Gonadotropin-Releasing Hormone: A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.Inhibins: Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectivelyLuteinizing Hormone: A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.Apudoma: A general term collectively applied to tumors associated with the APUD CELLS series, irrespective of their specific identification.Adrenal Glands: A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.Adrenal Gland Neoplasms: Tumors or cancer of the ADRENAL GLANDS.Adrenal Gland Diseases: Pathological processes of the ADRENAL GLANDS.Medical History Taking: Acquiring information from a patient on past medical conditions and treatments.Adrenal Cortex: The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.Adrenal Medulla: The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.Physical Examination: Systematic and thorough inspection of the patient for physical signs of disease or abnormality.Adrenal Insufficiency: Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.Salivary Glands: Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Morinda: A plant genus of the family RUBIACEAE. Members contain iridoid glycosides and ANTHRAQUINONES.Varicocele: A condition characterized by the dilated tortuous veins of the SPERMATIC CORD with a marked left-sided predominance. Adverse effect on male fertility occurs when varicocele leads to an increased scrotal (and testicular) temperature and reduced testicular volume.Cuscuta: A plant genus of the family Cuscutaceae. It is a threadlike climbing parasitic plant that is used in DRUGS, CHINESE HERBAL.Convolvulaceae: The morning glory family of flowering plants, of the order Solanales, which includes about 50 genera and at least 1,400 species. Leaves are alternate and flowers are funnel-shaped. Most are twining and erect herbs, with a few woody vines, trees, and shrubs.Allium: A genus of the plant family Liliaceae (sometimes classified as Alliaceae) in the order Liliales. Many produce pungent, often bacteriostatic and physiologically active compounds and are used as VEGETABLES; CONDIMENTS; and medicament, the latter in traditional medicine.Onions: Herbaceous biennial plants and their edible bulbs, belonging to the Liliaceae.Rubiaceae: The Madder plant family of the order Rubiales, subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.Ipomoea: A plant genus in the family CONVOLVULACEAE best known for morning glories (a common name also used with CONVOLVULUS) and sweet potato.Liliaceae: A monocot family within the order Liliales. This family is divided by some botanists into other families such as Convallariaceae, Hyacinthaceae and Amaryllidaceae. Amaryllidaceae, which have inferior ovaries, includes CRINUM; GALANTHUS; LYCORIS; and NARCISSUS and are known for AMARYLLIDACEAE ALKALOIDS.Infertility, Male: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.Trail Making Test: The subject's ability to connect 25 numbered and lettered circles in sequence in a specific length of time. A score of 12 or below is suggestive of organic brain damage.Attention Deficit Disorder with Hyperactivity: A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)Executive Function: A set of cognitive functions that controls complex, goal-directed thought and behavior. Executive function involves multiple domains, such as CONCEPT FORMATION, goal management, cognitive flexibility, INHIBITION control, and WORKING MEMORY. Impaired executive function is seen in a range of disorders, e.g., SCHIZOPHRENIA; and ADHD.Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Personality Disorders: A major deviation from normal patterns of behavior.Neuropsychological Tests: Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.Central Nervous System Stimulants: A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.Cognition Disorders: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.Cognition: Intellectual or mental process whereby an organism obtains knowledge.
(1/13) Successful treatment with ICSI of infertility caused by azoospermia associated with adrenal rests in the testes: case report.

Congenital adrenal hyperplasia (CAH) is a well-recognized, but uncommon, cause of azoospermia and infertility in men. Commonly this is due to undertreatment of excessive adrenal androgen secretion which suppresses gonadotrophin stimulation of the testes. A less common complication of CAH is development of adrenal tissue within the testes; this is important to recognize because it may be confused with malignancy leading to unnecessary surgery. In this case report, a man is described with simple virilizing CAH due to 21-hydroxylase deficiency who presented with azoospermia and was found to have adrenal rests. Investigations concluded that there was adequate adrenal suppression with glucocorticoids and that azoospermia was due to obstruction by adrenal rest tissue, strategically situated at the hilum of the testes. Spermatozoa were able to be retrieved by testicular aspiration from the man and these were used to successfully establish a pregnancy using intracytoplasmic sperm injection of his wife's oocytes.  (+info)

(2/13) Nonfunctioning adrenocortical carcinoma.

The rarity of adrenocortical carcinoma prompted us to report a case who came with a history of swelling in the left flank associated with pain, weakness and loss of appetite. Ultrasonography revealed a left retroperitoneal mass which was removed by radical surgery along with the left kidney and spleen. On histopathological examination, a diagnosis of adrenocortical carcinoma was made. (Hough criteria score 2.97). The cells of the tumor were arranged in closely packed columns and cords supported by fibrovascular stroma. There was no evidence of metastasis.  (+info)

(3/13) Prevalence of testicular adrenal rest tumours in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

OBJECTIVE: Testicular adrenal rest tumours (TART) are a well-known complication in adult male patients with congenital adrenal hyperplasia (CAH), with a reported prevalence of up to 94%. In adulthood, the tumours are associated with gonadal dysfunction most probably due to longstanding obstruction of the seminiferous tubules. The aim of our study was to determine the presence of TART and their influence on gonadal function in childhood. DESIGN: Retrospective study. PATIENTS AND METHODS: Scrotal ultrasound was performed in 34 children with CAH due to 21-hydroxylase deficiency who were between 2 and 18 years old. FSH, LH, testosterone and inhibin B concentrations were measured in serum of 27 patients. RESULTS: TART were detected by ultrasound in 8 out of 34 (24%) children. In two of them, bilateral tumours were found. All lesions were located in the rete testis. Seven patients had the salt-wasting type of CAH; one patient had the simple virilising type of CAH. Mean tumour size was 4.1 mm (range 2-8 mm). In none of the patients were the tumours palpable. Two children with TART were between 5 and 10 years old, the other six children were above 10 years old. In all children with TART, LH, FSH, testosterone and inhibin B levels were similar to the patients without TART. CONCLUSION: TART can be found in CAH children before the age of 10 years. The absence of gonadal dysfunction in our group of children suggests that gonadal dysfunction as frequently reported in adult CAH patients with TART develops after childhood.  (+info)

(4/13) An adrenal rest tumour in the perirenal region in a patient with congenital adrenal hyperplasia due to congenital 3beta-hydroxysteroid dehydrogenase deficiency.

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(5/13) The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency.

Development of a testicular adrenal rest tumor (TART) is common in males with congenital adrenal hyperplasia, and it can be an important cause of infertility. In the present study, we observed the prevalence of TARTs, and analyzed its associated factors in patients with 21-hydroxylase deficiency. Testicular ultrasonography was performed in 48 postpubertal male patients aged 10.6 to 27.1 years. To determine whether patients were undertreated, we analyzed the serum 17-hydroxyprogesterone (17-OHP) levels to the time of ultrasonographic measurement and calculated the percentage of measurements when serum 17-OHP level was >10 ng/mL relative to the total number of measurements during the follow-up period. We divided the 6-year period before ultrasonographic measurement (time 0) into three 2-year intervals and calculated the average concentration of serum 17-OHP in each interval to give a -2(nd) to 0 year-average concentration (-2-0YAC), -4-2YAC and -6-4YAC. A TART was detected by ultrasonography in 31 of 48 patients (64.6%) and the median maximal cross-sectional area of the TARTs was 0.71 (0.03, 4.95) cm(2). The corrected final adult height was lower, and -4-2YAC and body mass index were higher in patients with TART than in those without. After controlling for the type of 21-hydroxylase deficiency, hydrocortisone-equivalent dose, age, and -6-4YAC, the size of TART was associated with a high undertreatment percentage with a marginal statistical significance. These results suggest that strict disease control is mandatory and regular examination with testicular ultrasonography is recommended in male patients, regardless of the type of 21-hydroxylase deficiency.  (+info)

(6/13) Testicular adrenal rest tumor in infertile man with congenital adrenal hyperplasia: case report and literature review.

 (+info)

(7/13) Fertility, sexuality and testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia.

 (+info)

(8/13) Testicular adrenal rest tumours in boys with congenital adrenal hyperplasia: case report and literature review.

Nodular testicular lesions derived from adrenal tissue (testicular adrenal rest tumours - TART) in boys and men with congenital adrenal hyperplasia (CAH) lead to testicular structure damage, spermatogenesis disorders, and infertility. Hyperplasia of the ectopic adrenal tissue in testes is associated with high levels of the adrenocorticotropic hormone (ACTH) in blood serum. The development of non-invasive methods of diagnostic imaging allows detection of testicular lesions in adolescents and children. The basic method for TART detection is imaging with ultrasonography (USG) being the most widely available method. Since these mild testicular lesions can cause impaired fertility, periodic palpation and testicular ultrasonography should be performed in patients with CAH in order to prevent infertility.  (+info)

*  Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
2007). "Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal ... Infertility observed in adult males with congenital adrenal hyperplasia (CAH) has been associated with testicular adrenal rest ... Inborn errors of steroid metabolism Congenital adrenal hyperplasia Adrenal insufficiency Disorders of sexual development ... Congenital Adrenal Hyperplasia Guide to Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency for parents or patients ...
*  Adrenal tumor
Only 10% of adrenal pheochromocytomas are malignant, while the rest are benign tumors. The most clinically important feature of ... An adrenal tumor or adrenal mass is any benign or malignant neoplasms of the adrenal gland, several of which are notable for ... with surgery employed to remove the tumor once the patient is medically stable. An adrenal incidentaloma is an adrenal tumor ... Adrenal cancer is the presence of malignant adrenal tumors, and includes neuroblastoma, adrenocortical carcinoma and some ...
*  List of MeSH codes (C04)
... adrenal rest tumor MeSH C04.557.470.035.250 --- apudoma MeSH C04.557.470.035.320 --- cystadenoma MeSH C04.557.470.035.320.225 ... mixed tumor, malignant MeSH C04.557.435.530 --- mixed tumor, mesodermal MeSH C04.557.435.540 --- mixed tumor, mullerian MeSH ... extra-adrenal MeSH C04.557.465.625.650.700.705.220 --- carotid body tumor MeSH C04.557.465.625.650.700.705.340 --- glomus ... extra-adrenal MeSH C04.557.580.625.650.700.705.220 --- carotid body tumor MeSH C04.557.580.625.650.700.705.340 --- glomus ...
*  Prolactin-releasing peptide receptor
2003). "Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of ... Kemp DM, Lin JC, Ubeda M, Habener JF (2002). "NRSF/REST confers transcriptional repression of the GPR10 gene via a putative ... adrenocortical tumors, pheochromocytomas and neuroblastomas". Peptides. 23 (6): 1135-40. doi:10.1016/S0196-9781(02)00046-3. ...
*  Renal cell carcinoma
A probe is placed through the skin and into the tumor using real-time imaging of both the probe tip and the tumor by computed ... Vigorous criticism of Grawitz was provided by Oskar Stoerk in 1908, who considered the adrenal origin of renal tumours to be ... The partial nephrectomy involves the removal of the affected tissue only, sparing the rest of the kidney, Gerota's fascia and ... More specific subsets show a five-year survival rate of around 90-95% for tumors less than 4 cm. For larger tumors confined to ...
*  International Classification of Diseases for Oncology
NOS Masculinovoblastoma M8670/3 Steroid cell tumor, malignant M8641/0 Adrenal rest tumor M8680/0 Paraganglioma, benign M8680/1 ... Adrenal cortical tumor, benign Adrenal cortical tumor, NOS M8370/3 Adrenal cortical carcinoma (C74.0) Adrenal cortical ... NOS G cell tumor, NOS Gastrin cell tumor M8153/3 Gastinoma, malignant G cell tumor, malignant Gastrin cell tumor, malignant ... malignant Interstitial cell tumor, malignant M8660/0 Hilus cell tumor (C56.9) Hilar cell tumor M8670/0 Lipid cell tumor of ...
*  Pauline Pfeiffer
... his mother's autopsy report as indicating that Pauline had died due to a pheochromocytoma tumor on one of her adrenal glands. ... Pfeiffer spent the rest of her life in Key West, with frequent visits to California, until her death on October 1, 1951 at age ... His theory was that the phone call from Ernest had caused the tumor to secrete excessive adrenalin, and then stop, the ...
*  Lennox Broster
... a tumour of the adrenal cortex), and he asked Broster to operate on the new patient. Removal of the larger adrenal gland (an ... In 1933 became a full surgeon at the hospital, and he remained there as a consultant for the rest of his career. A history of ... Harris, Dean A.; Wheeler, Malcolm H. (2005). "History of adrenal surgery". In Linos, Dimitrios; van Heerden, Jon A. Adrenal ... "Surgery of the Adrenal". He also lectured on the adrenal gland during tours of the United States and Canada in 1936 and 1937. ...
*  Hyperthermia
Other rare causes of hyperthermia include thyrotoxicosis and an adrenal gland tumor, called pheochromocytoma, both of which can ... In this situation, the body's tolerance for high environmental temperature may be insufficient, even at rest. Heat waves are ... Passive cooling techniques, such as resting in a cool, shady area and removing clothing can be applied immediately. Active ... dominates by raising catecholamine levels by the blocked action of the Rest and Digest System. Drugs that decouple oxidative ...
*  Adrenergic storm
Rarely, a pheochromocytoma (tumor of the medullar tissue of the adrenal glands, which are located anterior to the kidney), may ... Like a seizure, sometimes a patient has a single one, or perhaps a few, and then does not for the rest of their life. The ... This type of tumor is not common to begin with, and furthermore, the subtype that can cause massive adrenaline release is rarer ... Whalen, R. K.; Althausen, A. F.; Daniels, G. H. (1992). "Extra-adrenal pheochromocytoma". The Journal of Urology. 147 (1): 1-10 ...
*  HINT2
At rest, intramitochondrial ([Ca2+]m) and cytosolic Ca2+ concentration ([Ca2+]i) are similar, of the order of 100 nM (9). The ... In mammals, HINT2 is expressed in the liver, adrenal cortex, and pancreas and localizes to the mitochondria within their cells ... Its exact role in tumor suppression remains unknown, though studies suggest it may promote apoptosis in hepatocellular ... This protein is an AMP-lysine hydrolase and phosphoamidase and may contribute to tumor suppression. As a member of the ...
*  Hypokalemia
These include renal artery stenosis and tumors (generally nonmalignant) of the adrenal glands, e.g., Conn's syndrome (primary ... This hyperpolarization is caused by the effect of the altered potassium gradient on resting membrane potential as defined by ... Lower potassium levels in the extracellular space cause hyperpolarization of the resting membrane potential. ... potassium is needed to repolarize the cell membrane to a resting state after an action potential has passed. ...
*  Tumor necrosis factor alpha
... who had been randomised to either rest or exercise prior to endotoxin administration. In resting subjects, endotoxin induced a ... Stimulation of the hypothalamic-pituitary-adrenal axis by stimulating the release of corticotropin releasing hormone (CRH) ... Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) ... Tumor Necrosis Factor-alpha at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal Medicine ...
*  Norepinephrine
A pheochromocytoma is a rarely occurring tumor of the adrenal medulla, caused either by genetic factors or certain types of ... In the rest of the body, norepinephrine increases heart rate and blood pressure, triggers the release of glucose from energy ... and adrenal glands. Sympathetic activation of the adrenal glands causes the part called the adrenal medulla to release ... The symptoms are widespread, the most serious being a reduction in heart rate and an extreme drop in resting blood pressure, ...
*  RAB18
2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries". Int. J. ... 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. ... "Synaptic vesicle proteins under conditions of rest and activation: analysis by 2-D difference gel electrophoresis". ...
*  Haptotaxis
Cells migrate easily and quickly in packs[citation needed], so when one cell moves the rest follow in response to the gradient ... Basara, M. L.; McCarthy, J. B.; Barnes, D. W.; Furcht, L. T. (1985). "Stimulation of haptotaxis and migration of tumor cells by ... The adrenocytes migrate centripetally as they mature towards the medulla of the adrenal gland., and this movement may be a ... This ability is not limited to tumor cells. Idiopathic pulmonary fibrosis (IPF) is a disease marked by fibrosis in lung ...
*  Delta wave
W. Grey Walter was the first person to use delta waves from an EEG to locate brain tumors and lesions causing temporal lobe ... 2014). Infra-slow EEG fluctuations are correlated with resting-state network dynamics in fMRI. [Article]. The Journal of ... Brandenberger, G. (2003). The Ulradien Rhythm of Sleep: Diverse Relations with Pituitary and Adrenal Hormones. Revue ... The location of cerebral tumors by electroencephalography. Lancet 1936;2: 305-8. "Biofeedback for Epileptic Seizures; EEG ...
*  Cannabinoid receptor type 1
However, as with the rest of the brain, it plays a crucial role in modulation of NT release. Selective CB1 agonists may be used ... CB1 is expressed on several types of cell in pituitary gland, thyroid gland, and possibly in the adrenal gland. CB1 is also ... Increased receptor expression has also been found in human hepatocellular carcinoma tumor samples and other human prostate ... synthesis of anandamide and 2-AG in response to stress mediated beneficial effects of the hypothalamic-pituitary-adrenal axis. ...
*  Hypothalamic-pituitary-adrenal axis
There is evidence shown that the HPA axis hormones can be linked to certain stress related skin diseases and skin tumors. This ... This corresponds to the rest-activity cycle of the organism. An abnormally flattened circadian cortisol cycle has been linked ... ACTH is transported by the blood to the adrenal cortex of the adrenal gland, where it rapidly stimulates biosynthesis of ... The hypothalamic-pituitary-adrenal axis (HPA axis or HTPA axis) is a complex set of direct influences and feedback interactions ...
*  Neuroendocrine tumor
Hindgut GEP-NET Liver and gallbladder Adrenal tumors, particularly adrenomedullary tumors Pheochromocytoma Peripheral nervous ... lung and the rest of the body. Although there are many kinds of NETs, they are treated as a group of tissue because the cells ... Small intestinal neuroendocrine tumors were first distinguished from other tumors in 1907. They were named carcinoid tumors ... Neuroendocrine thyroid tumors, particularly medullary carcinoma Parathyroid tumors Thymus and mediastinal carcinoid tumors ...
*  Annexin A1
In resting conditions, human and mouse immune cells such as neutrophils, monocytes, and macrophages contain high levels of ... Annexin A1 protects against DNA damage induced by heat in breast cancer cells, adding to the evidence that it has tumor ... long-term use of glucocorticoid drugs can lead to side-effects such as immunodeficiency and adrenal insufficiency. The main ... This data suggests that ANXA1 may act as a tumor suppressor gene and modulate the proliferative functions of estrogens. ...
*  Persistent vegetative state
... even if resting brain metabolism was severely impaired. However, this activation of primary cortex seems to be isolated and ... such as a tumor or abscess Vascular pressure which causes intracranial hemorrhaging or stroke Hypoxic ischemic injury ( ... Endocrine disorders such as adrenal insufficiency and thyroid disorders Degenerative and metabolic diseases including urea ...
*  Feline lower urinary tract disease
Consistent with this, elevated levels of catecholamines have been found in affected cats both at rest and during high stress ... Other conditions that can contribute to this disease include physical trauma, tumors of the urinary tract, intentional urinary ... Cats with FIC also have abnormalities in corticotropin stimulation and larger adrenal medullary areas, suggesting that they are ...
*  Sexual dysfunction
Other hormonal causes of erectile failure include brain tumors, hyperthyroidism, hypothyroidism or disorders of the adrenal ... In the rest, the medications may not work because of wrong diagnosis or chronic history. Another type of medication that is ... tumors, and, rarely, tertiary syphilis may also impact the activity, as could the failure of various organ systems (such as the ... heart and lungs), endocrine disorders (thyroid, pituitary, or adrenal gland problems), hormonal deficiencies (low testosterone ...
*  Adrenal insufficiency
Other cases are due to congenital adrenal hyperplasia or an adenoma (tumor) of the adrenal gland. Secondary adrenal ... prednisone or methylpredisolone tablets Rest Cortisol deficiency (primary and secondary) Hydrocortisone (Cortef) Prednisone ( ... "Dorlands Medical Dictionary:adrenal insufficiency". "Secondary Adrenal Insufficiency: Adrenal Disorders: Merck Manual ... Addison's disease and congenital adrenal hyperplasia can manifest as adrenal insufficiency. If not treated, adrenal ...
*  Prostate cancer
Eventually, the tumor may grow large enough to invade nearby organs such as the seminal vesicles or the rectum, or the tumor ... Prostate cancer rates are higher in developed countries than in the rest of the world. Many of the risk factors for prostate ... Androgens include testosterone, which is made in the testes; dehydroepiandrosterone, made in the adrenal glands; and ... The grade tells how much the tumor tissue differs from normal prostate tissue and suggests how fast the tumor is likely to grow ...
adrenal rest tumor disease finding 2005:2010[pubdate] *count=100 - BioMedLib™ search engine  adrenal rest tumor disease finding 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Adrenal Medulla / physiopathology. Adrenal Rest Tumor / etiology. Adrenal Rest Tumor / prevention & control. Adult. Continuity ... Adrenal Hyperplasia, Congenital / genetics. Adrenal Rest Tumor / genetics. Adrenal Rest Tumor / pathology. Steroid 21- ... Adrenal Hyperplasia, Congenital / ultrasonography. Adrenal Rest Tumor / pathology. Adrenal Rest Tumor / ultrasonography. ... Title] Hepatic adrenal rest tumor mimicking hepatocellular carcinoma.. *[MeSH-major] Adrenal Rest Tumor / radiography. Liver ...
more infohttp://www.bmlsearch.com/?kwr=adrenal+rest+tumor+disease+finding+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency - Wikipedia  Congenital adrenal hyperplasia due to 21-hydroxylase deficiency - Wikipedia
2007). "Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal ... Infertility observed in adult males with congenital adrenal hyperplasia (CAH) has been associated with testicular adrenal rest ... Inborn errors of steroid metabolism Congenital adrenal hyperplasia Adrenal insufficiency Disorders of sexual development ... Congenital Adrenal Hyperplasia Guide to Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency for parents or patients ...
more infohttps://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia_due_to_21-hydroxylase_deficiency
Genetics and clinical presentation of classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency  Genetics and clinical presentation of classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
... conversion of 17-hydroxyprogesterone to 11-deoxycortisol accounts for more than 90 percent of cases of congenital adrenal ... Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia. J ... Ovarian adrenal rest tumor in a congenital adrenal hyperplasia patient with adrenocorticotropin hypersecretion following ... Fertility, sexuality and testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia. Eur J Endocrinol ...
more infohttp://www.uptodate.com/contents/genetics-and-clinical-presentation-of-classic-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency
Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11...  Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11...
Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11. - ... "Prevalence of testicular adrenal rest tumors in male children with congenital adrenal hyperplasia due to 21-hydroxylase ... causing testicular masses known as testicular adrenal rest tumors (TARTs). Leydig cell tumors (LCTs) are make up a very small ... Tumors of adrenal rest tissue, LCTs, and Leydig cell hyperplasia are the primary etiologic considerations [7]. In this report, ...
more infohttps://www.hindawi.com/journals/criu/2012/648643/
Adrenal Rest Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials  Adrenal Rest Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
MalaCards integrated aliases for Adrenal Rest Tumor:. Name: Adrenal Rest Tumor 12 55 44 15 73 ... MalaCards based summary : Adrenal Rest Tumor, also known as adrenal rest neoplasm, is related to lipoid congenital adrenal ... Testicular adrenal rest tumor mimicking leydig cell tumor in a patient with congenital adrenal hyperplasia. ( 24834391 ) ... MalaCards organs/tissues related to Adrenal Rest Tumor:. 41 Liver, Ovary, Lung, Bone, Pituitary, Pineal, Cortex ...
more infohttps://www.malacards.org/card/adrenal_rest_tumor
Sonographic Spectrum of Testicular Adrenal Rest Tumors  Sonographic Spectrum of Testicular Adrenal Rest Tumors
Testicular adrenal rest tumors (TARTs) are a type of testicular neoplasm that is commonly associated with congenital adrenal ... Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia can cause severe testicular damage. Fertil ... Ali, H., Arabi, H., Samkari, A. Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with ... Testicular adrenal rest tumors in patients with congenital adrenal hyperplasia: prevalence and sonographic, hormonal, and ...
more infohttps://americanjs.com/article-text.php?q=1&1/15/Sonographic-Spectrum-of-Testicular-Adrenal-Rest-Tumors
adrenal benign rest tumor 2005:2010  - BioMedLib™ search engine  adrenal benign rest tumor 2005:2010 - BioMedLib™ search engine
Title] Hepatic adrenal rest tumor mimicking hepatocellular carcinoma.. *[MeSH-major] Adrenal Rest Tumor / radiography. Liver ... Adrenal Rest Tumor of the Liver Preoperatively Diagnosed as Hepatocellular Carcinoma.. *BACKGROUND: Hepatic adrenal rest tumors ... Title] Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to ... Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β- ...
more infohttp://bmlsearch.com/?kwr=adrenal%20benign%20rest%20tumor%202005:2010
Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia. -...  Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia. -...
... has been associated with testicular adrenal rest tumors (TART) that may originate during childhood. OBJECTIVE Our objective was ... CONTEXT Infertility observed in adult males with congenital adrenal hyperplasia (CAH) ... Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal hyperplasia.. *. ... Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia. *Min Kyung Yu. , Mo ...
more infohttps://www.semanticscholar.org/paper/Testicular-adrenal-rest-tumors-and-Leydig-and-Sert-Mart%C3%ADnez-Aguayo-Rocha/f300aad538af937d37bcc2dd93239747037c58a6
adrenal benign rest tumor diagnosis 2005:2010[pubdate] *count=100 - BioMedLib™ search engine  adrenal benign rest tumor diagnosis 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Adrenal Medulla / physiopathology. Adrenal Rest Tumor / etiology. Adrenal Rest Tumor / prevention & control. Adult. Continuity ... Adrenal Hyperplasia, Congenital / genetics. Adrenal Rest Tumor / genetics. Adrenal Rest Tumor / pathology. Steroid 21- ... Adrenal Hyperplasia, Congenital / ultrasonography. Adrenal Rest Tumor / pathology. Adrenal Rest Tumor / ultrasonography. ... Title] Hepatic adrenal rest tumor mimicking hepatocellular carcinoma.. *[MeSH-major] Adrenal Rest Tumor / radiography. Liver ...
more infohttp://www.bmlsearch.com/?kwr=adrenal+benign+rest+tumor+diagnosis+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency - Wikipedia  Congenital adrenal hyperplasia due to 21-hydroxylase deficiency - Wikipedia
Testicular adrenal rest tumors[edit]. Infertility observed in adult males with congenital adrenal hyperplasia (CAH) has been ... 2007). "Testicular adrenal rest tumors and Leydig and Sertoli cell function in boys with classical congenital adrenal ... associated with testicular adrenal rest tumors (TART) that may originate during childhood. TART in prepubertal males with ... The primary goals of hormone replacement are to protect from adrenal insufficiency and to suppress the excessive adrenal ...
more infohttps://en.wikipedia.org/wiki/21-hydroxylase_deficiency
HSD3B1 Gene - GeneCards | 3BHS1 Protein | 3BHS1 Antibody  HSD3B1 Gene - GeneCards | 3BHS1 Protein | 3BHS1 Antibody
adrenal rest tumor. *adrenal rest neoplasm. - elite association - COSMIC cancer census association via MalaCards ... Diseases associated with HSD3B1 include Testicular Leydig Cell Tumor and Lipoid Congenital Adrenal Hyperplasia. Among its ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=HSD3B1
MC2R | Cancer Genetics Web  MC2R | Cancer Genetics Web
CONTEXT: Testicular adrenal rest tumors (TART) are one of the major long term complications in patients with congenital adrenal ... Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both ... OBJECTIVE: Testicular adrenal rest tumours (TARTs) are a common finding in patients with congenital adrenal hyperplasia (CAH). ... In a series of 114 patients with various adrenal and non-adrenal tumors, the rate of heterozygosity was 100 %. Only one out of ...
more infohttp://www.cancerindex.org/geneweb/MC2R.htm
December 1970 - Volume 36 - Issue 6 : Obstetrics & Gynecology  December 1970 - Volume 36 - Issue 6 : Obstetrics & Gynecology
Adrenal Rest Cell Tumor of the Ovary: Report of a Case. SOBRINHO, L G; KASE, N G ...
more infohttps://journals.lww.com/greenjournal/toc/1970/12000
International Classification of Diseases for Oncology  International Classification of Diseases for Oncology
A benign, testicular or ovarian tumor, derived from adrenal embryonic rest cells. It is composed of hyperplastic adrenal ... A benign, testicular or ovarian tumor, derived from adrenal embryonic rest cells. It is composed of hyperplastic adrenal ... 8671/0 Adrenal rest tumor. Definitions. Testis/Male genital organs. ICD-O-3 topography code: C62-C63. ...
more infohttp://codes.iarc.fr/code/3197
C-17 Hydroxylase Deficiency Treatment & Management: Medical Care, Surgical Care, Consultations  C-17 Hydroxylase Deficiency Treatment & Management: Medical Care, Surgical Care, Consultations
The rare variant of congenital adrenal hyperplasia (CAH) known as 17-hydroxylase deficiency was first described in the 1960s in ... Molecular Characterization of Testicular Adrenal Rest Tumors in Congenital Adrenal Hyperplasia; Lesions with both ... Sexuality and Testicular Adrenal Rest Tumors in Adult Males with Congenital Adrenal Hyperplasia. Eur J Endocrinol. 2011 Dec 9. ... Congenital adrenal hyperplasia. Bardin CW. Current Therapy in Endocrinology and Metabolism. 6th ed. St Louis, Mo: Mosby- ...
more infohttps://emedicine.medscape.com/article/117140-treatment
C-17 Hydroxylase Deficiency Medication: Glucocorticoids, Estrogens, Progestogens, Androgens, Antihypertensive agents,...  C-17 Hydroxylase Deficiency Medication: Glucocorticoids, Estrogens, Progestogens, Androgens, Antihypertensive agents,...
The rare variant of congenital adrenal hyperplasia (CAH) known as 17-hydroxylase deficiency was first described in the 1960s in ... Molecular Characterization of Testicular Adrenal Rest Tumors in Congenital Adrenal Hyperplasia; Lesions with both ... Sexuality and Testicular Adrenal Rest Tumors in Adult Males with Congenital Adrenal Hyperplasia. Eur J Endocrinol. 2011 Dec 9. ... Use of adrenal androgen replacement therapy is controversial and not FDA-approved. However, the fact that DHEA constitutes a ...
more infohttps://emedicine.medscape.com/article/117140-medication
A Klinefelter boy with congenital adrenal hyperplasia: too much or too little androgens? | Springer for Research & Development  A Klinefelter boy with congenital adrenal hyperplasia: too much or too little androgens? | Springer for Research & Development
... and Congenital Adrenal Hyperplasia (CAH) is an exceptional event: there are just three case reports (two children and a 51 ... Testes ultrasound showed no signs of adrenal rest tumor.. He had wholly developed pubic hair and a pubertal penis length. He ... A new testes ultrasound showed small testis with no signs of adrenal rest tumor. ... Budzyńska E, Beń-Skowronek I. Testicular adrenal rest tumours in boys with congenital adrenal hyperplasia: case report and ...
more infohttps://rd.springer.com/article/10.1186/s13052-018-0485-x
Article - Essentials of scrotal ultrasound: A review of frequently encountered abnormalities  Article - Essentials of scrotal ultrasound: A review of frequently encountered abnormalities
Unusual scrotal masses: Thinking beyond germ cell tumors. Poster. * Maizlin ZV, Strauss S. Testicular adrenal rest tumors. Isr ... Testicular adrenal rest tissue in congential adrenal hyperplasia: Comparison of MR imaging and sonographic findings. AJR Am J ... ectopic adrenal rest tissue is frequently identified within the testicles. In response to elevated levels of ACTH, this rest ... tumors. The commonest germ cell tumors are seminomas, mixed germ cell tumors, and teratomas. The ultrasound appearance of ...
more infohttps://www.appliedradiology.com/articles/essentials-of-scrotal-ultrasound-a-review-of-frequently-encountered-abnormalities
Acth-Independent Macronodular Adrenal Hyperplasia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials  Acth-Independent Macronodular Adrenal Hyperplasia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
adrenal rest tumor 10.0. GNRH1 MC2R 30. diabetes insipidus, neurohypophyseal 9.9. AVPR2 GNRH1 ... Study of Adrenal Gland Tumors. Recruiting. NCT00005927 Search. NIH Clinical Center for Acth-Independent Macronodular Adrenal ... MalaCards organs/tissues related to Acth-Independent Macronodular Adrenal Hyperplasia:. 42 Adrenal Gland, Pituitary, Ovary, ... macronodular adrenal hyperplasia cushing syndrome acth-independent hypercortisolemia enlarged adrenal glands Neurologic Central ...
more infohttps://www.malacards.org/card/acth_independent_macronodular_adrenal_hyperplasia
Infertility and Reproductive Function in Patients with Congenital Adrenal Hyperplasia: Pathophysiology, Advances in Management,...  Infertility and Reproductive Function in Patients with Congenital Adrenal Hyperplasia: Pathophysiology, Advances in Management,...
... whereas in men testicular adrenal rest tumors can be a major cause of infertility. Suppression of adrenal androgen secretion ... Individuals with congenital adrenal hyperplasia have reduced fertility. However, reproductive outcomes have improved over the ... alterations of the hypothalamic-pituitary-gonadal axis to the direct effect on gonadal function by elevated circulating adrenal ... Bilateral ovary adrenal rest tumor in a congenital adrenal hyperplasia following adrenalectomy.. Magda G Zaarour, David Atallah ...
more infohttps://www.semanticscholar.org/paper/Infertility-and-Reproductive-Function-in-Patients-Lekarev-Lin-Su/2c0d2ff05e44756eb7eff01bc7b4e37d537b04f4
  • The enzyme P450c21, commonly referred to as 21-hydroxylase (21-OH), is embedded in the smooth endoplasmic reticulum of the cells of the adrenal cortex. (wikipedia.org)
  • Steroid precursors up to and including progesterone, 17α-hydroxypregnenolone, and especially 17α-hydroxyprogesterone accumulate in the adrenal cortex and in circulating blood. (wikipedia.org)
  • however, it is known that in some normal neonates adrenal tissue remnants remain in the testes-the result of aberrant adrenal cortical tissue that adhered to the gonads and descended during prenatal life. (americanjs.com)
  • We conducted an integrated analysis of transcriptome and methylome data of paired APA-adjacent adrenal gland (AAG) samples from the same patient. (cancerindex.org)
  • The adrenal medulla is located anatomically at the center of each adrenal gland, and is composed of neuroendocrine (chromaffin) cells which produce and release epinephrine (adrenaline) into the bloodstream in response to activation of the sympathetic nervous system. (wikipedia.org)
  • Pheochromocytoma is a neoplasm composed of cells similar to the chromaffin cells of the mature adrenal medulla. (wikipedia.org)
  • Although both ultrasound and magnetic resonance imaging (MRI) are proven methods of diagnosis, ultrasound is preferred due to greater accessibility, lower cost, and higher sensitivity in the detection of tumors. (americanjs.com)
  • Testes ultrasound showed no signs of adrenal rest tumor. (springer.com)
  • Primary adrenal teratoma: An unusual tumor - Challenges in diagnosis and surgical management. (readbyqxmd.com)
  • Although the tumor has often spread to distant parts of the body at the time of diagnosis, this cancer is unusual in that many cases are highly curable when the spread is limited to the liver, skin, and/or bone marrow (stage IVS). (wikipedia.org)
  • An important gene associated with Adrenal Rest Tumor is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2), and among its related pathways/superpathways are Metabolism and Cushing syndrome . (malacards.org)
  • Computed tomography scan revealed an adrenal mass for which a right open transperitoneal adrenalectomy was performed, and the lesion was diagnosed as mature teratoma on histopathological examination. (readbyqxmd.com)