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Adrenal Cortex NeoplasmsAdrenal CortexAdrenal GlandsAdrenal MedullaZona ReticularisAdrenal Gland NeoplasmsAdrenal Cortex DiseasesAdrenal Gland DiseasesAdrenocorticotropic HormoneZona FasciculataCerebral CortexAdrenal InsufficiencyPrefrontal CortexVisual CortexZona GlomerulosaAdrenocortical AdenomaSteroid 11-beta-HydroxylaseMotor CortexAdrenal Cortex Function TestsAdrenal Cortex HormonesAdrenocortical CarcinomaAuditory CortexAdrenal Hyperplasia, CongenitalSomatosensory CortexCosyntropinAldosteroneAdrenalectomyHydrocortisoneAdrenodoxinCorticosteroneAldosterone SynthaseCholesterol Side-Chain Cleavage EnzymeSteroidogenic Factor 1CattleSteroid 21-HydroxylaseCushing SyndromeAdrenocortical HyperfunctionAddison DiseaseSteroid 17-alpha-HydroxylaseEntorhinal CortexAdenomaPancreatic NeoplasmsAdosterolPregnenoloneKidney CortexImmunohistochemistryNeoplasmsFerredoxin-NADP Reductase17-HydroxycorticosteroidsBrain MappingHyperaldosteronismMagnetic Resonance ImagingPituitary-Adrenal SystemSteroids3-Hydroxysteroid DehydrogenasesNeoplasms, Cystic, Mucinous, and SerousPheochromocytomaChromaffin CellsDehydroepiandrosteroneCatecholaminesReceptor, Melanocortin, Type 2RNA, MessengerCerebellar CortexHypothalamo-Hypophyseal SystemHypophysectomyMitochondriaAdrenarcheAminoglutethimideRats, Sprague-DawleyProgesterone ReductaseBrainNeoplasms, Multiple PrimaryDehydroepiandrosterone SulfateRats, Inbred StrainsNeuronsGlucocorticoidsMetyraponeSkin NeoplasmsSteroid HydroxylasesCytochrome P-450 Enzyme SystemTime FactorsHistocytochemistryRats, WistarMicroscopy, ElectronFrontal LobeHyperplasiaOrgan SpecificityPhotic StimulationNeural PathwaysAngiotensin IIFetusOrgan SizeTissue DistributionDexamethasoneKidney NeoplasmsMineralocorticoidsChromaffin SystemNeoplasms, Second PrimaryMolecular Sequence DataIn Situ Hybridization
Adrenal Cortex Neoplasms
Tumors or cancers of the ADRENAL CORTEX.
Adrenal Cortex
The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.
Adrenal Glands
A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.
Adrenal Medulla
The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.
Zona Reticularis
The inner zone of the adrenal cortex. This zone produces the enzymes that convert PREGNENOLONE, a 21-carbon steroid, to 19-carbon steroids (DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE) via 17-ALPHA-HYDROXYPREGNENOLONE.
Adrenal Gland Neoplasms
Tumors or cancer of the ADRENAL GLANDS.
Adrenal Cortex Diseases
Pathological processes of the ADRENAL CORTEX.
Adrenal Gland Diseases
Pathological processes of the ADRENAL GLANDS.
Adrenocorticotropic Hormone
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Zona Fasciculata
The wide middle zone of the adrenal cortex. This zone produces a series of enzymes that convert PREGNENOLONE to cortisol (HYDROCORTISONE) via 17-ALPHA-HYDROXYPROGESTERONE.
Cerebral Cortex
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Adrenal Insufficiency
Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.
Prefrontal Cortex
The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the MEDIODORSAL NUCLEUS OF THE THALAMUS. The prefrontal cortex receives afferent fibers from numerous structures of the DIENCEPHALON; MESENCEPHALON; and LIMBIC SYSTEM as well as cortical afferents of visual, auditory, and somatic origin.
Visual Cortex
Area of the OCCIPITAL LOBE concerned with the processing of visual information relayed via VISUAL PATHWAYS.
Zona Glomerulosa
The narrow subcapsular outer zone of the adrenal cortex. This zone produces a series of enzymes that convert PREGNENOLONE to ALDOSTERONE. The final steps involve three successive oxidations by CYTOCHROME P-450 CYP11B2.
Adrenocortical Adenoma
A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.
Steroid 11-beta-Hydroxylase
A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Motor Cortex
Area of the FRONTAL LOBE concerned with primary motor control located in the dorsal PRECENTRAL GYRUS immediately anterior to the central sulcus. It is comprised of three areas: the primary motor cortex located on the anterior paracentral lobule on the medial surface of the brain; the premotor cortex located anterior to the primary motor cortex; and the supplementary motor area located on the midline surface of the hemisphere anterior to the primary motor cortex.
Adrenal Cortex Function Tests
Examinations that evaluate and monitor hormone production in the adrenal cortex.
Adrenal Cortex Hormones
Adrenocortical Carcinoma
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Auditory Cortex
The region of the cerebral cortex that receives the auditory radiation from the MEDIAL GENICULATE BODY.
Adrenal Hyperplasia, Congenital
A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.
Somatosensory Cortex
Area of the parietal lobe concerned with receiving sensations such as movement, pain, pressure, position, temperature, touch, and vibration. It lies posterior to the central sulcus.
Cosyntropin
A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of ADRENOCORTICOTROPIC HORMONE. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of CORTICOSTEROIDS in the ADRENAL CORTEX.
Aldosterone
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
Adrenalectomy
Excision of one or both adrenal glands. (From Dorland, 28th ed)
Hydrocortisone
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
Adrenodoxin
An iron-sulfur protein which serves as an electron carrier in enzymatic steroid hydroxylation reactions in adrenal cortex mitochondria. The electron transport system which catalyzes this reaction consists of adrenodoxin reductase, NADP, adrenodoxin, and cytochrome P-450.
Corticosterone
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
Aldosterone Synthase
A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.
Cholesterol Side-Chain Cleavage Enzyme
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
Steroidogenic Factor 1
A transcription factor and member of the nuclear receptor family NR5 that is expressed throughout the adrenal and reproductive axes during development. It plays an important role in sexual differentiation, formation of primary steroidogenic tissues, and their functions in post-natal and adult life. It regulates the expression of key steroidogenic enzymes.
Cattle
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Steroid 21-Hydroxylase
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Cushing Syndrome
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
Adrenocortical Hyperfunction
Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.
Addison Disease
An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.
Steroid 17-alpha-Hydroxylase
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
Entorhinal Cortex
Cerebral cortex region on the medial aspect of the PARAHIPPOCAMPAL GYRUS, immediately caudal to the OLFACTORY CORTEX of the uncus. The entorhinal cortex is the origin of the major neural fiber system afferent to the HIPPOCAMPAL FORMATION, the so-called PERFORANT PATHWAY.
Adenoma
A benign epithelial tumor with a glandular organization.
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Adosterol
A sterol usually substituted with radioactive iodine. It is an adrenal cortex scanning agent with demonstrated high adrenal concentration and superior adrenal imaging.
Pregnenolone
A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.
Kidney Cortex
The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.
Immunohistochemistry
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Ferredoxin-NADP Reductase
An enzyme that catalyzes the oxidation and reduction of FERREDOXIN or ADRENODOXIN in the presence of NADP. EC 1.18.1.2 was formerly listed as EC 1.6.7.1 and EC 1.6.99.4.
17-Hydroxycorticosteroids
A group of hydroxycorticosteroids bearing a hydroxy group at the 17-position. Urinary excretion of these compounds is used as an index of adrenal function. They are used systemically in the free alcohol form, but with esterification of the hydroxy groups, topical effectiveness is increased.
Brain Mapping
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Hyperaldosteronism
A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.
Magnetic Resonance Imaging
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Pituitary-Adrenal System
The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.
Steroids
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
3-Hydroxysteroid Dehydrogenases
Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids.
Neoplasms, Cystic, Mucinous, and Serous
Neoplasms containing cyst-like formations or producing mucin or serum.
Pheochromocytoma
A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
Chromaffin Cells
Cells that store epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia (PARAGANGLIA, CHROMAFFIN) of the sympathetic nervous system.
Dehydroepiandrosterone
A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
Catecholamines
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
Receptor, Melanocortin, Type 2
A melanocortin receptor subtype found primarily in the ADRENAL CORTEX. It shows specificity for ADRENOCORTICOTROPIC HORMONE.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Cerebellar Cortex
The superficial GRAY MATTER of the CEREBELLUM. It consists of two main layers, the stratum moleculare and the stratum granulosum.
Hypothalamo-Hypophyseal System
A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.
Hypophysectomy
Surgical removal or destruction of the hypophysis, or pituitary gland. (Dorland, 28th ed)
Mitochondria
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Adrenarche
A stage of development at which the ADRENAL GLANDS undergo maturation leading to the capability of producing increasing amounts of adrenal androgens, DEHYDROEPIANDROSTERONE and ANDROSTENEDIONE. Adrenarche usually begins at about 7 or 8 years of age before the signs of PUBERTY and continues throughout puberty.
Aminoglutethimide
An aromatase inhibitor that is used in the treatment of advanced BREAST CANCER.
Rats, Sprague-Dawley
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Progesterone Reductase
An enzyme that catalyzes the reduction of a 3 beta-hydroxy-delta(5)-steroid to 3-oxo-delta(4)-steroid in the presence of NAD. It converts pregnenolone to progesterone and dehydroepiandrosterone to androstenedione. EC 1.1.1.145.
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Neoplasms, Multiple Primary
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Dehydroepiandrosterone Sulfate
The circulating form of a major C19 steroid produced primarily by the ADRENAL CORTEX. DHEA sulfate serves as a precursor for TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE.
Rats, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Neurons
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Glucocorticoids
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Metyrapone
An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
Skin Neoplasms
Tumors or cancer of the SKIN.
Steroid Hydroxylases
Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.
Cytochrome P-450 Enzyme System
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Histocytochemistry
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Rats, Wistar
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Microscopy, Electron
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Frontal Lobe
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
Hyperplasia
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Organ Specificity
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Photic Stimulation
Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.
Neural Pathways
Neural tracts connecting one part of the nervous system with another.
Angiotensin II
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Fetus
The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.
Organ Size
The measurement of an organ in volume, mass, or heaviness.
Tissue Distribution
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Dexamethasone
An anti-inflammatory 9-fluoro-glucocorticoid.
Kidney Neoplasms
Tumors or cancers of the KIDNEY.
Mineralocorticoids
A group of CORTICOSTEROIDS primarily associated with water and electrolyte balance. This is accomplished through the effect on ION TRANSPORT in renal tubules, resulting in retention of sodium and loss of potassium. Mineralocorticoid secretion is itself regulated by PLASMA VOLUME, serum potassium, and ANGIOTENSIN II.
Chromaffin System
The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs.
Neoplasms, Second Primary
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
In Situ Hybridization
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Functional Laterality
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
Parietal Lobe
Upper central part of the cerebral hemisphere. It is located posterior to central sulcus, anterior to the OCCIPITAL LOBE, and superior to the TEMPORAL LOBES.
Gyrus Cinguli
One of the convolutions on the medial surface of the CEREBRAL HEMISPHERES. It surrounds the rostral part of the brain and CORPUS CALLOSUM and forms part of the LIMBIC SYSTEM.
Thyroid Neoplasms
Tumors or cancer of the THYROID GLAND.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Autoradiography
The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)

Primary aldosteronism with aldosterone-producing adrenal adenoma in a pregnant woman. (1/605)

A 30-year-old pregnant woman complained of muscle weakness at 29 weeks' gestation. She was hypertensive with severe hypokalemia. Lower plasma renin activity and higher aldosterone level than the normal values in pregnancy suggested primary aldosteronism. A cesarean delivery was performed at 31 weeks' gestation because of pulmonary congestion. The neonatal course was uncomplicated. The laparoscopic adrenalectomy for a 2.0-cm right adrenal adenoma resulted in normalizing of her blood pressure and serum potassium level. Although primary aldosteronism is rare, especially during pregnancy, it should be always considered as one of etiologies of hypertension in pregnancy.  (+info)

The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. (2/605)

Inhibins and activins are dimeric proteins of the transforming growth factor-beta superfamily which have been shown to be expressed in the adrenal cortex. Recent studies have suggested a role for these peptides in the pathogenesis and/or function of adrenal tumours. To investigate further their physiological and pathological roles, we have documented immunoreactivity for inhibin alpha, betaA and betaB subunits in normal adult and fetal human adrenals, in hyperplastic adrenals and in adrenal tumours. In the normal and hyperplastic adult gland, diffuse immunopositivity was demonstrated for beta subunits, suggesting that activins (beta beta dimers) can be expressed in all zones. Inhibin alpha was limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia, supporting a role for ACTH in the regulation of expression, and suggesting that expression of inhibins (alpha beta dimers) is restricted. Immunopositivity for all three subunits was seen in both fetal and definitive zones of the fetal cortex, indicating that both inhibins and activins could be expressed in both. Immunopositivity for all three subunits was seen in most adrenocortical tumours. Loss of immunopositivity for inhibin alpha in a subgroup of carcinomas might indicate a role in tumour progression. The greater intensity of staining for inhibin alpha in tumours associated with Cushing's syndrome again suggests a link with cortisol production.  (+info)

Androgen secreting adrenocortical tumours. (3/605)

BACKGROUND: Androgen secreting adrenocortical tumours are rare in children and the determination of their malignant potential can be difficult. OBJECTIVES: To assess the presentation, histology, and clinical behaviour of these tumours. SETTING: Two tertiary referral centres. STUDY DESIGN: Retrospective analysis of children diagnosed with an androgen secreting adrenocortical tumour between 1976 and 1996. PATIENTS: Twenty three girls and seven boys aged 0-14 years. RESULTS: Pubic hair was observed in all children, clitoromegaly or growth of the phallus in 23 children, acceleration of linear growth in 22 children, and advanced bone age (> 1.5 years) in 18 children. Hypersecretion of androgens was detected by assessment of serum androgen concentrations alone in four patients and by 24 hour urine steroid excretion profiles in 22 patients. All 16 tumours measuring < 5 cm in diameter were benign. Of the tumours measuring 5-9 cm, three were malignant and seven were benign, whereas all four tumours > 10 cm were malignant. Histological slides were available for reassessment in 25 children. Although mitoses and necrosis were more characteristic of tumours with malignant behaviour, no exclusive histological features of malignancy were seen. CONCLUSION: Histological criteria for malignancy are not reliable, whereas tumour size is important in assessing malignant potential.  (+info)

Adrenocortical oncocytoma. (4/605)

The histopathology and ultrastructural features of an adrenocortical oncocytoma are reported. The tumour was discovered incidentally during investigation for hypertension in a 72 year old female. Oncocytic tumours of the adrenal cortex are rare, with only 20 examples described in English language reports. Most have been non-functioning and benign, like the present example. Molecular studies may help assess the significance of oncocytic change in the pathogenesis and behaviour of oncocytic neoplasms.  (+info)

Cloning of a novel kinase (SIK) of the SNF1/AMPK family from high salt diet-treated rat adrenal. (5/605)

PCR-coupled cDNA subtraction hybridization was adapted to identify the genes expressed in the adrenocortical tissues from high salt diet-treated rat. A novel cDNA clone, termed salt-inducible kinase (SIK), encoding a polypeptide (776 amino acids) with significant similarity to protein serine/ threonine kinases in the SNF1/AMPK family was isolated. An in vitro kinase assay demonstrated that SIK protein had autophosphorylation activity. Northern blot revealed that SIK mRNA levels were markedly augmented by ACTH treatment both in rat adrenal glands and in Y1 cells. SIK may play an important role in the regulation of adrenocortical functions in response to high plasma salt and ACTH stimulation.  (+info)

Autocrine role of IGF-II in proliferation of human adrenocortical carcinoma NCI H295R cell line. (6/605)

In adrenocortical tumors, the malignant phenotype is associated with rearrangements (paternal isodisomy) at the 11p15 locus and IGF-II gene overexpression, strongly suggesting that the IGF system is a major determinant of adrenocortical tumor progression. The aim of this study was to validate an in vitro model for investigating the involvement of the IGF system in adrenocortical tumorigenesis. We analyzed the production of IGF mRNA and proteins, IGF-binding proteins (IGFBPs) and IGF receptors by the NCI H295R cell line, which is derived from a human adult adrenocortical carcinoma. H295R cells were shown to proliferate for a long period (26 days) in the absence of serum or any added growth factor. Northern blot analyses showed high IGF-II mRNA contents in H295R cells. The cells secreted large amounts of IGF-II protein (14 ng/10(6) cells per 48 h) although no IGF-I protein was detected. Western ligand blot analyses of conditioned media detected the presence of large amounts of a 34 kDa protein, which was identified as IGFBP-2 by immunoblotting. The presence of high-affinity binding sites for IGF-I and IGF-II on H295R cells was shown by binding experiments using radiolabeled IGFs and confirmed by reverse transcription PCR analyses showing type 1 and type 2 IGF receptors. Proliferation of H295R cells was inhibited by anti-IGF-II antibody (45%) and by anti-type 1 IGF receptor antibody (53%) indicating that IGF-II is an autocrine growth factor for these cells and that its effects are, at least in part, mediated by the type 1 IGF receptor. These findings confirm the involvement of the IGF system in adrenocortical tumors and suggest that the H295R cell line is a suitable in vitro model for studying the molecular mechanisms of adrenocortical tumor proliferation.  (+info)

Evidence for a potential role for HDL as an important source of cholesterol in human adrenocortical tumors via the CLA-1 pathway. (7/605)

CLA-1, a human homologue of rodent scavenger receptor class B1 (SR-B1), has been identified as a receptor for high density lipoprotein (HDL) and is highly expressed in the adrenal gland. Several studies have indicated that HDL might be a source of cholesterol for steroidogenesis in the adrenal gland. In this study, we show that ACTH and its second messenger cAMP stimulated CLA-1 protein expression in a human adrenocortical cell line. We also determined whether CLA-1 plays an important role in steroidogenesis by investigating CLA-1 expression levels in various adrenal tumors including the adenomas of Cushing's and Conn's syndrome. Western blot analysis showed that CLA-1 expression was much higher in the tumors of Cushing's syndrome than in non-tumor lesions of Conn's syndrome and pheochromocytoma. We were able to detect a strong CLA-1 signal in tumors of Conn's syndrome, too. On the other hand, much less CLA-1 expression was detected in Cushing's adenoma adjacent adrenal glands. The immunohistochemical analysis showed that CLA-1 was expressed in the outer region of the adrenal cortex mainly in plasma membranes of the cortical cells but not in the medulla. These findings demonstrated for the first time that ACTH increased CLA-1 protein in cultured human adrenocortical cells, and that cortisol- and aldosterone-secreting adenomas had high CLA-1 proteins in their cell surfaces.  (+info)

A patient with preclinical Cushing's syndrome and excessive DHEA-S secretion having unilateral adrenal carcinoma and contralateral adenoma. (8/605)

We report a case of preclinical Cushing's syndrome in a 54-year-old male associated with bilateral adrenocortical tumours. Physical findings and general laboratory data were unremarkable except for mild hypertension (158/90 mmHg) and impaired glucose tolerance. Endocrinological evaluation revealed the presence of autonomous cortisol secretion including unsuppressible serum cortisol by 8 mg dexamethasone test (11 microg/dl), high serum DHEA-S (3580 ng/ml, normal: 400-3500) and increased urinary 17-KS excretion (31.0-35.8 mg/day, normal: 5.8-21.3). CT scan demonstrated the presence of tumours in both adrenals and bilateral adrenalectomy was subsequently performed. Histological examination of the resected specimens revealed an adrenocortical carcinoma on the right side and an adenoma on the left side with noticeable cortical atrophy in non-neoplastic adrenals. Immunohistochemical study of steroidogenic enzymes demonstrated that all the steroidogenic enzymes involved in cortisol biosynthesis were expressed in both right and left adrenal tumours. Enzymatic activities of 21, 17alpha, 18, 11beta-hydroxylases were detected in both right and left adrenals except for the absence of 11beta-hydroxylase activity in the left adrenal adenoma. Results of in vitro tissue steroidogenesis examined in short-term tissue culture of the specimens revealed no significant differences between carcinoma and adenoma in cortisol production, but the production of adrenal androgens in carcinoma was significantly higher than that in adenoma, which may indicate the importance of evaluating adrenal androgen levels in patients with adrenocortical neoplasms.  (+info)

Laparoscopic resection of adrenal cortical carcinoma: A cautionary note<...Laparoscopic resection of adrenal cortical carcinoma: A cautionary note<...
TY - JOUR. T1 - Laparoscopic resection of adrenal cortical carcinoma. T2 - A cautionary note. AU - Gonzalez, Ricardo J.. AU - Shapiro, Suzanne. AU - Sarlis, Nicholas. AU - Vassilopoulou-Sellin, Rena. AU - Perrier, Nancy D.. AU - Evans, Douglas B.. AU - Lee, Jeffrey E.. AU - Inabnet, William B.. AU - Libutti, Steven K.. AU - Chen, Herbert. AU - Duh, Quan Yang. AU - Wilhelm, Scott. PY - 2005/12/1. Y1 - 2005/12/1. N2 - Background. While laparoscopic removal of small, benign, functioning adrenal tumors is accepted, laparoscopic resection of adrenal tumors that may be adrenal cortical carcinoma (ACC) remains controversial. Methods. The records of all patients with ACC evaluated at a single institution from 1991 through 2004 were reviewed retrospectively. Results. Among 170 patients with ACC, 153 patients underwent open anterior adrenalectomy, 6 underwent laparoscopic adrenalectomy, 1 was treated via an open flank approach, and 10 had no operation. At a median follow-up of 28 months, 115 (86%) of 133 ...
https://einstein.pure.elsevier.com/en/publications/laparoscopic-resection-of-adrenal-cortical-carcinoma-a-cautionary-2
Non steroidogenic | Neurosteroid biosynthesis: genes for adrenal steroidogenic.
The focus on the refinement, reduction and replacement of animal use in toxicity testing requires the development of cell-based systems that mimic the effects of xenobiotics in human tissues. The human adrenocortical carcinoma cell line, H295R, has been
http://lks.stoynev.us/non-steroidogenic.html
CD44 expression in normal adrenal tissue and adrenal tumours. | Journal of Clinical PathologyCD44 expression in normal adrenal tissue and adrenal tumours. | Journal of Clinical Pathology
BACKGROUND: CD44 is a cell surface glycoprotein found on many normal cells, mainly lymphoid and epithelial. Normal cells usually express standard CD44 (CD44-S), whereas malignant tumours may express CD44 variant isoforms (CD44-V). CD44 expression has been described for neural crest derivatives. Characterisation of differences in CD44 expression may help in the diagnosis and differentiation of distinct adrenal tumours. AIMS: To examine CD44 expression in different layers of cortical cortex, in adrenal medulla, and in adrenal tumours. METHODS: CD44-S and CD44-V6 expression were studied in 12 cases of adrenal cortical adenoma, 3 of adrenal cortical carcinoma, 10 of pheochromocytoma, and 4 normal adrenal glands. RESULTS: CD44-V6 staining showed cytoplasmic expression in normal adrenal cortex and in cortical adenomas and carcinomas. Pheochromocytomas also showed CD44-V6 expression but in 5 of the 10 cases it was sparse, focal, and sometimes perinuclear. Strong membranous staining for CD44-S was ...
https://jcp.bmj.com/content/51/1/52
Management of the Clinically Inapparent Adrenal Mass | Annals of Internal Medicine | American College of PhysiciansManagement of the Clinically Inapparent Adrenal Mass | Annals of Internal Medicine | American College of Physicians
1. The major issue to resolve with the various imaging techniques is the differentiation of benign adrenal adenomas from adrenal cortical carcinoma, since biochemical tests can distinguish an adrenal adenoma from a pheochromocytoma. As Dr. Copeland has noted, approximately half of the adrenal masses in patients with known cancer represent metastasis (1). It is in that group of patients that fine-needle aspiration of the adrenal mass is most useful in excluding metastatic disease if the findings on imaging are equivocal. In the study Dr. Copeland cites to advocate the routine use of delayed enhanced CT (2), 39 of the 40 malignant adrenal incidentalomas were metastatic lesions, while the remaining lesion was a malignant pheochromocytoma. None were adrenal cortical carcinomas. Until we have sufficient data that this procedure regularly distinguishes between primary adrenal adenomas and carcinomas, additional research is needed ...
http://annals.org/aim/article-abstract/717264/management-clinically-inapparent-adrenal-mass
Adrenal Cortical Carcinoma - RxMed.comAdrenal Cortical Carcinoma - RxMed.com
Treatment:. The main method of adrenal tumor treatment is surgery.. At the first stage of tumor development, when the formation does not exceed 5 cm and there is no metastasis, laparoscopic removal is performed.. If the tumor has reached the second stage of development and has grown more than 5 cm, then the method of removal is determined by doctors based on MRI or CT.. At stage 3 of adrenal cancer, when the tumor affects the lymph nodes, a cavitary surgery is indicated. During removal, the surgeon examines nearby organs and tissues for the presence of metastases.. Adrenal cancer of the 4th stage is usually accompanied by metastatic sprouting in the tissue of the kidneys, liver, etc. Such tumors are not always operable. The possibility of prompt removal is determined by the doctor individually.. As additional treatment, other methods are used. Radiotherapy is actively used in pheochromocytomas.. A patient can get a radioactive isotope injection, which kills cancer cells, reducing the size of the ...
https://www.rxmed.com/illness/adrenal-cortical-carcinoma
AdrenalGland - Schema Index
Note 2: Except for histologies that have strictly histology-based CS schemas (for example lymphoma), all cases with primary site adrenal gland (C74._) are coded with this schema. However, only adrenal cortical carcinomas will have AJCC stage derived (7th Edition only). Adrenal cortical carcinoma is identified as C74.0 (adrenal cortex) with histology 8010, 8140, or 8370 OR C74.9 (adrenal gland, NOS) with histology 8370 ...
http://web2.facs.org/cstage0205/adrenalgland/AdrenalGlandschema.html
A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced...
TY - JOUR. T1 - A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma. AU - Xie, Hao. AU - Yin, Jun. AU - Shah, Manisha H.. AU - Menefee, Michael E.. AU - Bible, Keith C.. AU - Reidy-Lagunes, Diane. AU - Kane, Madeleine A.. AU - Quinn, David I.. AU - Gandara, David R.. AU - Erlichman, Charles. AU - Adjei, Alex. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background Adrenal cortical carcinoma (ACC) is a rare cancer with treatment options of limited efficacy, and poor prognosis if metastatic. AT-101 is a more potent inhibitor of B cell lymphoma 2 family apoptosis-related proteins than its racemic form, gossypol, which showed preliminary clinical activity in ACC. We thus evaluated the efficacy of AT-101 in patients with advanced ACC. Methods Patients with histologically confirmed metastatic, recurrent, or primarily unresectable ACC were treated with AT-101 (20 mg/day orally, 21 days out of 28-day cycles) ...
https://mayoclinic.pure.elsevier.com/en/publications/a-phase-ii-study-of-the-orally-administered-negative-enantiomer-o
Adrenal Cortical CarcinomaAdrenal Cortical Carcinoma
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http://www.psychiatryadvisor.com/endocrinology-metabolism/adrenal-cortical-carcinoma/article/595716/
OPUS Würzburg | Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomasOPUS Würzburg | Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas
Somatic mutations in protein kinase A catalytic α subunit (PRKACA) were found to be causative for 30-40% of cortisol-producing adenomas (CPA) of the adrenal gland, rendering PKA signalling constitutively active. In its resting state, PKA is a stable and inactive heterotetramer, consisting of two catalytic and two regulatory subunits with the latter inhibiting PKA activity. The human genome encodes three different PKA catalytic subunits and four different regulatory subunits that are preferentially expressed in different organs. In normal adrenal glands all regulatory subunits are expressed, while CPA exhibit reduced protein levels of the regulatory subunit IIβ. In this study, we linked for the first time the loss of RIIβ protein levels to the PRKACA mutation status and found the down-regulation of RIIβ to arise post-transcriptionally. We further found the PKA subunit expression pattern of different tumours is also present in the zones of the normal adrenal cortex and demonstrate that the different
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/searchtype/authorsearch/author/%22Dalmazi%2C+Guido+Di%22/docId/15795/start/0/rows/10
Most recent papers with the keyword Adrenal tumor children | Read by QxMDMost recent papers with the keyword Adrenal tumor children | Read by QxMD
Childhood adrenocortical tumors (ACTs) are rare, representing ∼0.2% of all pediatric malignancies and having an incidence of 0.2-0.3 new cases per million per year in the United States, but incidences are remarkably higher in Southern Brazil. At diagnosis, most children show signs and symptoms of virilization, Cushing syndrome, or both. Less than 10% of patients with ACT exhibit no endocrine syndrome at presentation, although some show abnormal concentrations of adrenal cortex hormones. Pediatric ACT is commonly associated with constitutional genetic and/or epigenetic alterations, represented by germline TP53 mutations or chromosome 11p abnormalities ...
https://read.qxmd.com/keyword/119741
Genevisible - Top 10 cancers for NM 000624
Top 10 cancers for NM_000624 (Homo sapiens, RefSeq): cortex of adrenal gland, adrenal cortical adenoma, NOS, cortex of adrenal gland, adrenal gland, cortex of adrenal gland, adrenal cortical carcinoma, adrenal gland, aldosterone-producing adenoma, adrenal gland, unspecified, neoplasms of endocrine glands and related structures, liver, hepatoblastoma, NOS, liver, hepatocellular carcinoma, NOS,metastatic, PDX/CDX, liver, dysplastic nodule
https://genevisible.com/cancers/HS/RefSeq/NM_000624
Browse In Signs and Symptoms, Kyphoscoliosis | EDM Case ReportsBrowse In Signs and Symptoms, Kyphoscoliosis | EDM Case Reports
Adrenal cortical carcinoma (ACC) has previously only been reported in eight patients with type 1 neurofibromatosis (NF1). There has not been any clear evidence of a causal association between NF1 gene mutations and adrenocortical malignancy development. We report the case of a 49-year-old female, with no family history of endocrinopathy, who was diagnosed with ACC on the background of NF1, due to a novel germline frame shift mutation (c.5452_5453delAT) in exon 37 of the NF1 gene. A left adrenal mass was detected by ultrasound and characterised by contrast computerised tomography (CT) scan. Biochemical tests showed mild hypercortisolism and androgen excess. A 24-h urinary steroid profile and 18flouro deoxy glucose PET suggested ACC. An open adrenalectomy was performed and histology confirmed ACC. This is the first reported case with DNA analysis, which demonstrated the loss of heterozygosity (LOH) at the NF1 locus in the adrenal cancer, supporting the hypothesis of an involvement of the NF1 gene ...
https://edm.bioscientifica.com/browse?pageSize=10&sort=datedescending&t=signs-symptoms&t_1=signs-symptoms_425
Protein Expression of Cyclin B1, Transferrin Receptor, and Fibronectin Is Correlated with the Prognosis of Adrenal Cortical...Protein Expression of Cyclin B1, Transferrin Receptor, and Fibronectin Is Correlated with the Prognosis of Adrenal Cortical...
Adrenal cortical carcinoma (ACC) is a rare cancer, with an annual incidence of about 1-2 per million [1]. ACC has a poor prognosis, with a 5-year overall survival rate of less than 40% for all cancers and 10% for metastatic cancers [2]. However, even in metastatic ACC, the prognosis is quite variable, with reported survival ranging from a few months to more than 10 years, suggesting the heterogeneity of these tumors [3]. Tumor, node, metastasis (TNM) staging has been used as a predictor of survival and has been modified to improve its prognostic power; currently, the eighth edition of TNM staging and European Network for the Study of Adrenal Tumors (ENSAT) staging systems are used [4,5,6]. Nevertheless, a significant proportion of patients with localized disease according to TNM staging experience recurrence after surgery (up to 70% within 3 years), which is the only curative treatment to date [2]. Tumor grade, as assessed by mitotic count and proliferation indices such as the Ki-67 index, has ...
https://e-enm.org/journal/view.php?number=2012
Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor - Full Text View -...Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor - Full Text View -...
This phase III clinical trial is studying how well cisplatin-based chemotherapy and/or surgery works in treating young patients with stage I, stage II, stage III or stage IV adrenocortical cancer. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Giving chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving it after surgery may kill any tumor cells that remain after surgery ...
https://clinicaltrials.gov/ct2/show/NCT00304070?term=COG+ARAR0332&rank=1
Flag Drugstore: Viagra mapuche antofagasta prime quality!Flag Drugstore: Viagra mapuche antofagasta prime quality!
Neurosci biobehav rev. Where they or a bronze appearance), this can often be improved by early diagnosis and management intestinal bleeding. Serum bilirubin levels greater than 400 mg orally daily with ritonavir ence, resistance patterns, side effects, and fatigue. Or peripheral aromatization of adrenal cortical carcinoma is a very high recurrence in the general population, segmental waveforms or ities. Lahn m, kohler g, kulmburg p, et al: Laparoscopic 147:124228. Rapid diagnostic testing (see chapter 10), surgical site infection, certain patient groups. Jacc cardiovasc interv. Am j some studies sug- combination of uric acid production, abrupt and fulminant. The line, desipramine, or imipramine, may be due to arteriolar necrosis and hem- the testis is palpated from the tumor questioned the high incidence of rebleeding c. Surgical portosystemic shunts usually cause disseminated calcification in a patient with type 1 diabetes, since they have little impact in danis rb et al. Proton pump inhibitors ...
http://wsradio.com/surgeon/viagra-mapuche-antofagasta/93/
Study of Adrenal Gland Tumors - Full Text View - ClinicalTrials.govStudy of Adrenal Gland Tumors - Full Text View - ClinicalTrials.gov
The adrenal glands are the major source in the body of the steroid hormones. In normal physiology, the pituitary hormone ACTH regulates the secretion of glucocorticoids, while the secretion of mineralocorticoids such as aldosterone is controlled by the renin-angiotensin system. In addition to these two classes of steroids, the adrenal gland secretes lesser amounts of intermediate metabolites as well as dehydroepiandrosterone (DHEA) and its sulfated product (DHEAS) and androstenedione, testosterone, estrogen, and estrone. Dysregulated secretion of any of these hormones can be caused by sporadic adrenocortical adenomas or carcinomas, with the development of specific clinical syndromes depending on the identity of the hormones secreted. In at least a subset of cortisol-producing adrenocortical neoplasms, the presence of ectopic or abnormal receptors has been described, resulting in the regulation of cortisol and/or aldosterone by non-physiologic stimuli. The present study will serve as a mechanism ...
https://clinicaltrials.gov/ct2/show/NCT00005927?cond=%22Adenoma+of+the+adrenal+gland%22&rank=5
MTMT2: CAI Yun et al. Association between c ongenital adrenal hyperplasia and adrenocortical tumors. (2013) Chin J Clinicians...MTMT2: CAI Yun et al. Association between c ongenital adrenal hyperplasia and adrenocortical tumors. (2013) Chin J Clinicians...
CAI Yun et al. Association between c ongenital adrenal hyperplasia and adrenocortical tumors. (2013) Chin J Clinicians(Electronic Edition) 7 22 10298- ...
https://m2.mtmt.hu/api/citation/24361155
Adrenal carcinoma - Radiology ImagingAdrenal carcinoma - Radiology Imaging
An interesting phenomenon consists of adrenal collision tumors. Thus a contiguous adrenal adenoma and metastasis results in the adenoma component displaying a signal loss on opposed-phase MR images and the metastatic component increasing in signal intensity. At times neither a biopsy nor a resected specimen allows adequate evaluation of an adrenocortical tumor if only histologic criteria are employed; immunohistologic staining is often helpful. Nevertheless, even then the true nature of a tumor may not be apparent. For example, CT and US discovered an incidental homogeneous adrenal tumor in a 43-year-old woman; endocrine tests revealed preclinical Cushings syndrome. An adrenalectomy was performed, and histology revealed an adrenocorticaltumor of undetermined nature, 4 months later the patient presented with a metastatic cortisol and androgen-producing adrenocortical carcinoma ...
http://radiology-information.blogspot.com/2014/04/adrenal-carcinoma.html
OPUS Würzburg | SearchOPUS Würzburg | Search
Adrenocortical tumors consist of benign adenomas and highly malignant carcinomas with a still incompletely understood pathogenesis. A total of 46 adrenocortical tumors (24 adenomas and 22 carcinomas) were investigated aiming to identify novel genes involved in adrenocortical tumorigenesis. High-resolution single nucleotide polymorphism arrays (Affymetrix) were used to detect copy number alterations (CNAs) and copy neutral losses of heterozygosity (cnLOH). Genomic clustering showed good separation between adenomas and carcinomas, with best partition including only chromosome 5, which was highly amplified in 17/22 malignant tumors. The malignant tumors had more relevant genomic aberrations than benign tumors, such as a higher median number of recurrent CNA (2631 vs 94), CNAs ,100 Kb (62.5 vs 7) and CN losses (72.5 vs 5.5), and a higher percentage of samples with cnLOH (91% vs 29%). Within the carcinoma cohort, a precise genetic pattern (i.e. large gains at chr 5, 7, 12, and 19, and losses at chr ...
https://opus.bibliothek.uni-wuerzburg.de/solrsearch/index/search/searchtype/authorsearch/author/%22Henzel%2C+Katharina%22
Plus itPlus it
Purpose: ,p,Adrenal incidentalomas must be differentiated from adrenocortical cancer (ACC). Currently, size, growth, and imaging characteristics determine the potential for malignancy but are imperfect. The aim was to evaluate whether urinary small molecules (,800 Da) are associated with ACC.,/p, ,p,Experimental Design:,/p, ,p,Preoperative fasting urine specimens from patients with ACC (n=19) and benign adrenal tumors (n=46) were analyzed by unbiased ultra performance liquid chromatography/mass spectrometry. Creatinine-normalized features were analyzed by Progenesis, SIMCA, and unpaired t-test adjusted by false discovery rate. Features with an AUC ,0.8 were identified through fragmentation patterns and database searches. All lead features were assessed in an independent set from patients with ACC (n=11) and benign adrenal tumors (n=46) and in a subset of tissue samples from patients with ACC (n=15) and benign adrenal tumors (n=15) in the training set.,/p, ,p,Results:,/p, ,p,Sixty-nine features ...
http://clincancerres.aacrjournals.org/content/early/2017/04/27/1078-0432.CCR-16-3156
The Division of Biology & Biomedical SciencesThe Division of Biology & Biomedical Sciences
Another area of interest is the role of GATA factors in the regulation of steroidogenic cell differentiation. Our experimental system takes advantage of the observation that GATA-4 normally is expressed in gonadal but not adrenocortical steroidogenic cells of the adult mouse. Interestingly, certain inbred strains of mice develop sex steroid-producing adrenocortical neoplasms in response to prepubertal gonadectomy. This phenomenon is thought to reflect metaplasia of competent cells in the adrenal gland, which transform into gonadal-like stroma in response to changes in the hormonal milieu, and increased expression of GATA4 is a hallmark of this transformation. To examine the signaling pathways involved in this form of tissue-type switching, we have created new inbred and transgenic models of adrenocortical neoplasia .. ...
http://dbbs.wustl.edu/faculty/Pages/faculty_bio.aspx?SID=1644
ReP USP - Detalhe do registro: Cloning and characterization of genes induced by FGF2 and ACTH in mouse adrenocortical Y1 cells
Asprino, P. F., & Armelin, H. A. (2002). Cloning and characterization of genes induced by FGF2 and ACTH in mouse adrenocortical Y1 cells. In Programa e Resumos. São Paulo: SBBq ...
https://repositorio.usp.br/item/001263887
TP53 p.R337H is a conditional cancer-predisposing mutation : further evidence from a homozygous patientTP53 p.R337H is a conditional cancer-predisposing mutation : further evidence from a homozygous patient
Background: Adrenocortical carcinomas (ACCs) are among the most common childhood cancers occurring in infants affected with the Li-Fraumeni and Li- Fraumeni-like (LFS/LFL) syndromes, which are caused by dominant germline mutations in the TP53 gene. In Brazil, a particular mutation, occurring in the tetramerisation domain of the gene, p.R337H, is exceedingly common due to a founder effect and is strongly associated with ACC. In this report, we describe the phenotype and long-term clinical follow-up of a female child diagnosed with ACC and homozygous for the TP53 p.R337H founder mutation. Case presentation: At age 11 months, the patient was diagnosed with a virilising anaplastic adrenal cortical tumour, which was completely excised without disturbing the adrenal capsule. Family history was consistent with an LFL tumour pattern, and genotyping identified the TP53 p.R337H mutation in both alleles in genomic DNA from lymphocytes and fibroblasts. Haplotype analysis confirmed the occurrence of the ...
http://www.lume.ufrgs.br/handle/10183/110028
Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11β-hydroxylase<...
TY - JOUR. T1 - Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11β-hydroxylase. AU - Mouw, A. R.. AU - Rice, D. A.. AU - Meade, J. C.. AU - Chua, S. C.. AU - White, P. C.. AU - Schimmer, B. P.. AU - Parker, K. L.. PY - 1989/1/1. Y1 - 1989/1/1. N2 - The mouse gene encoding adrenal steroid 11β-hydroxylase (11β-OHase) has been cloned and the nucleotide sequence of its 5 end has been determined. The coding regions sequenced are homologous (75%) to the sequence of bovine 11β-OHase cDNA. The 5-flanking region of the 11β-OHase gene contains a potential cAMP response element (TGACGTGA) located 56 base pairs upstream of the transcription initiation site (position -56) and two motifs at positions -249 and -148 which are similar to an element postulated to be required for the expression of 21-hydroxylase. Transfection of mouse Y1 adrenocortical tumor cells and MA-10 testicular Leydig cells with plasmids containing the 11β-OHase promoter linked to a ...
https://utsouthwestern.pure.elsevier.com/en/publications/structural-and-functional-analysis-of-the-promoter-region-of-the-
Adrenals - Humpath.com - Human pathology
Adrenocortical Tumors: Improving the Practice of the Weiss System Through Virtual Microscopy: A National Program of the French Network INCa-COMETE. Tissier F, Aubert S, Leteurtre E, Al Ghuzlan A, Patey M, Decaussin M, Doucet L, Gobet F, Hoang C, Mazerolles C, Monges G, Renaudin K, Sturm N, Trouette H, Vacher-Lavenu MC, Viallon V, Baudin E, Bertagna X, Coste J, Libe R. Am J Surg Pathol. 2012 Aug;36(8):1194-1201. PMID: (...). ...
http://humpath.com/spip.php?rubrique42
Research Roundup - Environmental Nutrition ArticleResearch Roundup - Environmental Nutrition Article
Drinking tomato juice may reduce platelet aggregation in people with type 2 diabetes. The friendly bacteria found in yogurt may help reduce inflammation associated with arthritis. Fish oil supplements may help people with systemic lupus.
https://www.environmentalnutrition.com/issues/27_11/researchroundup/151074-1.html
mebendazole lung cancermebendazole lung cancer
Rodriguez-Bravo, V.; Galsky, M.; Cordon-Cardo, C.; Domingo-Domenech, J. Martarelli, D.; Pompei, P.; Baldi, C.; Mazzoni, G. Mebendazole inhibits growth of human adrenocortical carcinoma cell lines implanted in nude mice. Williamson, T.; Bai, R.Y. Most importantly, daily oral mebendazole prevented established thyroid tumors from metastasizing to the lung. In addition, the tumor vascularity in vivo was quantitated in control and MZ-treated mice using a hemoglobin assay. ; Springer, C.J. B, significant growth inhibition was observed when nu/nu mice were fed 1 mg of MZ every other day. . ; Marshall, C.J. Lung cancer has become the leading cause of cancer death in the world (1). The statements, opinions and data contained in the journal, © 1996-2020 MDPI (Basel, Switzerland) unless otherwise stated. Davis, R.J.; Van Waes, C.; Allen, C.T. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. You seem to have ...
http://facebus.net/69w23rg/mebendazole-lung-cancer-22c051
Adrenocortical Carcinoma Adrenal Cortex Cancer, Pipeline Review, H1 2015Adrenocortical Carcinoma Adrenal Cortex Cancer, Pipeline Review, H1 2015
Adrenocortical Carcinoma (Adrenal Cortex Cancer)-Pipeline Review, H1 2015. Summary. Global Markets Directs, Adrenocortical Carcinoma (Adrenal Cortex Cancer)-Pipeline Review, H1 2015, provides an overview of the Adrenocortical Carcinoma (Adrenal Cortex Cancer)s therapeutic pipeline.. This report provides comprehensive information on the therapeutic development for Adrenocortical Carcinoma (Adrenal Cortex Cancer), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Adrenocortical Carcinoma (Adrenal Cortex Cancer) and special features on late-stage and discontinued projects.. Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data ...
https://www.kenresearch.com/healthcare/pharmaceuticals/adrenocortical-carcinoma-adrenal-cortex-cancer-pipeline/8755-91.html
Adrenocortical carcinoma secreting cortisol, androgens and aldosterone: a case report | Cases Journal | Full TextAdrenocortical carcinoma secreting cortisol, androgens and aldosterone: a case report | Cases Journal | Full Text
Adrenocortical carcinoma is a rare malignancy with a poor prognosis and presents with mass effects and less often with signs of hormone excess (approximately 60% of all adrenocortical carcinomas). Hormonally active adrenocortical carcinomas most commonly secrete cortisol while the co-secretion of multiple steroid hormones is rare. We report the case of a 59 year-old woman with a medical history of hyperaldosteronism due to a right adrenal adenoma. During follow up, she showed symptoms of hypercortisolism and hyperandrogenemia and a rapid growth of the adrenal mass. She underwent right adrenalectomy and the histology revealed the presence of an adrenocortical carcinoma. Six months post-operatively being on treatment with mitotane, she was diagnosed of metastatic disease to the liver. She underwent right hepatectomy and was started on systemic chemotherapy, with no signs of tumour recurrence during the following six months. The hormonal status should be carefully investigated in all cases of suspected
https://casesjournal.biomedcentral.com/articles/10.4076/1757-1626-2-8951
11C-metomidate PET imaging of adrenocortical cancer11C-metomidate PET imaging of adrenocortical cancer
Adrenocortical cancer (ACC) is a rare disease that is often difficult to diagnose, and therefore often presents at an advanced stage. Various cytotoxic treatments have been tried with little success. Evaluation of new diagnostic methods and improvement of medical therapies are therefore crucial.. The diagnostic potential of 11C-metomidate positron emission tomography (PET) was evaluated in eleven ACC patients. PET visualized all viable tumors with high tracer uptake, including two lesions that CT failed to detect. Necrotic or fibrotic tumors were PET negative. Medication with adrenal steroid inhibitors and chemotherapy may decrease the tracer uptake.. We performed a phase-II study with streptozocin and o,p-DDD (SO) combination therapy in 40 ACC patients. The SO therapy was found to have impact on the disease-free interval (P = 0.02) as well as on survival (P = 0.01) in patients who received adjuvant therapy after curative resection. Complete or partial response was obtained in 36.4% of patients ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:164511
Adrenocortical Carcinoma
Adrenocortical Carcinoma, also called adrenal cortical carcinoma, is the formation of cancer in the outer layer (cortex) of an adrenal gland. This is the forum for discussing anything related to this health condition
https://www.healthician.org/forumdisplay.php?580-Adrenocortical-Carcinoma&s=b4ffec8ce0e8f4dd2fbda3b31a201efc
Rare Cancer News & Clinical Trials » PubMed - Adrenocortical CarcinomaRare Cancer News & Clinical Trials » PubMed - Adrenocortical Carcinoma
Adrenocortical carcinoma is a rare entity. However, it is the most common type of cancerous adrenal gland tumor with poor prognosis. Approximately 4 to 12 per 1 million people develop this type of tumor, which begins in the adrenal cortex. Adrenocortical carcinoma can occur at any age. Women tend to be diagnosed slightly more often than men. In most cases, the cause of cancerous adrenal gland tumor remains unknown. However, people with certain hereditary conditions have a higher risk. Adrenocortical carcinoma can be a functional or nonfunctional tumor. If the tumor is functional, it may produce hormones causing symptoms such as high blood pressure, low potassium level, heart palpitations, nervousness, feelings of anxiety or panic attacks, excessive perspiration, diabetes, Cushing syndrome, unexplained weight gain or weight loss, weakness, abdominal stretch marks, excessive hair growth, changes in genitalia, change in libido, etc. If the tumor is nonfunctional, symptoms occur because the tumor ...
http://news.rare-cancer.org/PubMed_-_Adrenocortical_Carcinoma/
Papers with the keyword Adrenal cortical neoplasms histologic criteria for malignancy | Read by QxMDPapers with the keyword Adrenal cortical neoplasms histologic criteria for malignancy | Read by QxMD
Adrenocortical carcinoma is an unusual tumor that tends to be larger than 100 g at diagnosis. Malignant adrenocortical tumors of less than 50 g have been reported rarely. We studied a small adrenocortical carcinoma that weighed 40 g and metastasized 3 1/2 years following bilateral adrenalectomy. The malignancy of adrenocortical tumors is frequently difficult to determine. Two recent studies have proposed histologic criteria for determining the malignancy of adrenal cortical tumors. Since the tumor we studied was initially judged to be benign, we sought to determine whether an extensive evaluation of this tumor using these recent criteria could have identified the tumors potential for metastasizing ...
https://www.readbyqxmd.com/keyword/28740
Adrenocortical Carcinoma Treatment
There are different types of treatment for patients with adrenocortical carcinoma.. Different types of treatments are available for patients with adrenocortical carcinoma. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.. Three types of standard treatment are used:. Surgery. Surgery to remove the adrenal gland (adrenalectomy) is often used to treat adrenocortical carcinoma. Sometimes surgery is done to remove the nearby lymph nodes and other tissue where the cancer has spread.. Radiation therapy. Radiation ...
https://www.missouricancer.com/cancer_type/adrenocortical-carcinoma-treatment/
Adrenocortical Carcinoma - Pipeline Review, H1 2017Adrenocortical Carcinoma - Pipeline Review, H1 2017
Adrenocortical Carcinoma - Pipeline Review, H1 2017 Adrenocortical Carcinoma - Pipeline Review, H1 2017 Summary Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline guide Adrenocortical Carcinoma - Market research report and industry analysis - 10909461
https://www.marketresearch.com/Global-Markets-Direct-v3480/Adrenocortical-Carcinoma-Pipeline-Review-H1-10909461/
Adrenal Tumors and Adrenal Masses, an OverviewAdrenal Tumors and Adrenal Masses, an Overview
Adrenal masses and adrenal tumors occur commonly with some being quite dangerous. Learn the basics of adrenal tumors from the worlds top adrenal surgeon.
https://www.adrenal.com/adrenal-tumors/overview
Adrenocortical hyperplasia | definition of adrenocortical hyperplasia by Medical dictionaryAdrenocortical hyperplasia | definition of adrenocortical hyperplasia by Medical dictionary
Looking for online definition of adrenocortical hyperplasia in the Medical Dictionary? adrenocortical hyperplasia explanation free. What is adrenocortical hyperplasia? Meaning of adrenocortical hyperplasia medical term. What does adrenocortical hyperplasia mean?
http://medical-dictionary.thefreedictionary.com/adrenocortical+hyperplasia
Adrenocortical Cancer | Harrisons Manual of Oncology, 2e | AccessHemOnc | McGraw-Hill MedicalAdrenocortical Cancer | Harrisons Manual of Oncology, 2e | AccessHemOnc | McGraw-Hill Medical
At the time of disease discovery there may be no symptoms (the tumor may be found incidentally on imaging). In other patients there may be symptoms of hormone excess or complaints referable to an abdominal mass. Hormone excess presents clinically as Cushings syndrome, virilization, feminization, or, less frequently, hypertension with hypokalemia. Hormone hypersecretion can be found in as many as 73%-79% of ACC patients, although not all patients have symptoms (2). In one study, amongst 45 ACC patients, routine biochemistry documented hormone excess in 33 (73%) with excess glucocorticoid and adrenal androgen in 12, isolated glucocorticoid in 11, isolated adrenal androgen in 7, and 17β-estradiol excess in combination with glucocorticoid and adrenal androgen excess in two and one, respectively. Steroid profiling revealed predominantly immature, early-stage steroid precursors, and their production most likely a consequence of altered expression of steroidogenic enzymes in variably undifferentiated ...
http://hemonc.mhmedical.com/content.aspx?bookid=1799§ionid=124754633
The possible role of apoptosis-suppressing genes, bcl-2 and mcl-1/EAT in human adrenal tumors<...
TY - JOUR. T1 - The possible role of apoptosis-suppressing genes, bcl-2 and mcl-1/EAT in human adrenal tumors. AU - Ando, Takashi. AU - Shibata, Hirotaka. AU - Suzuki, Toshihiko. AU - Kurihara, Isao. AU - Hayashi, Kouichi. AU - Hayashi, Matsuhiko. AU - Saito, Ikuo. AU - Kawabe, Hiroshi. AU - Tsujioka, Minako. AU - Saruta, Takao. PY - 1998/1/1. Y1 - 1998/1/1. N2 - The expression levels of bcl-2, mcl-1/EAT, and bax were examined by Northern blot analysis and semi-quantitative RT-PCR method in 25 adrenal tumors, including seven adrenal pheochromocytomas (PHE), seven aldosterone- producing adenomas (APA), four adrenal cortisol-producing adenomas (CS), one deoxycorticosterone-producing adenoma (DOC) and six non-hyperfunctioning adrenal cortical adenomas (NF). Northern blot analysis revealed both bcl-2 and mcl-1/EAT mRNAs in all of the adrenal tumors. The expression levels differed greatly among the tumor samples. Mcl-1/EAT mRNA levels were enhanced in APA and CS compared with those in NF. In ...
https://keio.pure.elsevier.com/en/publications/the-possible-role-of-apoptosis-suppressing-genes-bcl-2-and-mcl-1e
A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy | Experimental oncologyA case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy | Experimental oncology
Adrenocortical cancer is an extremely rare tumor presenting with extensive locoregional spread at the time of diagnosis. Due to the diagnostic difficulties
https://exp-oncology.com.ua/article/11711/a-case-report-of-late-local-relapse-of-adrenocortical-carcinoma-18-years-after-adrenalectomy
Endocrine Cancer
Endocrine cancer can happen by chance, can be caused by environmental exposures, could be caused by a combination of genetic factors, or can be caused by a mutation in a gene.. Certain types of endocrine cancers are more likely to be genetic than others, such as medullary thyroid cancer or adrenal cortical carcinoma in children. Other times endocrine cancers are caused by other factors. Individuals with genetic syndromes have a mutation (or change) in a gene that causes them to be at increased for breast cancer. These mutations are typically inherited from a either parent and can be passed on to children. People with genetic cancer syndromes may be at risk to develop other types of cancers as well. Learning if you have a cancer syndrome can help you understand your risk to develop cancer, your familys risk to develop cancer, and potentially provide you with ways to reduce your cancer risk. ...
http://healthsource.baylorhealth.com/22,endocrinecancer
Search Results | ercSearch Results | erc
Abnormal expression of membrane receptors has been previously described in benign adrenocortical neoplasms causing Cushings syndrome. In particular, we have observed that, in some adreno corticotropic hormone (ACTH)-independent macronodular adrenal hyperplasia tissues, cortisol secretion is controlled by ectopic serotonin7 (5-HT7) receptors. The objective of the present study was to investigate in vitro the effect of serotonin (5-hydroxy tryptamine; 5-HT) on cortisol and renin production by a left adrenocortical carcinoma removed from a 48-year-old female patient with severe Cushings syndrome and elevated plasma renin levels. Tumor explants were obtained at surgery and processed for immunohistochemistry, in situ hybridization and cell culture studies. 5-HT-like immunoreactivity was observed in mast cells and steroidogenic cells disseminated in the tissue. 5-HT stimulated cortisol release by cultured cells. The stimulatory effect of 5-HT on cortisol secretion was suppressed by the 5-HT7 ...
https://erc.bioscientifica.com/search?f_0=abstract&f_1=abstract&f_2=abstract&f_3=abstract&f_4=abstract&f_5=abstract&f_6=abstract&f_7=abstract&f_8=abstract&f_9=abstract&f_10=abstract&f_11=abstract&o_1=OR&o_2=OR&o_3=OR&o_4=OR&o_5=OR&o_6=OR&o_7=OR&o_8=OR&o_9=OR&o_10=OR&o_11=OR&o_12=OR&q_0=Cushing%27s&q_1=Cortisol&q_2=ACTH&q_3=Adreno
Rare Cancer News & Clinical Trials » Google - Adrenocortical CarcinomaRare Cancer News & Clinical Trials » Google - Adrenocortical Carcinoma
Infinity also announced today that it is adding two additional cohorts to the combination expansion component of the study, one in mesothelioma and one in adrenocortical carcinoma (cancer of the adrenal gland). These two new cohorts are based in part ... ...
http://news.rare-cancer.org/Google_-_Adrenocortical_Carcinoma/
Impact of standardised reporting in adrenocortical carcinoma: a single centre clinicopathological review | Journal of Clinical...Impact of standardised reporting in adrenocortical carcinoma: a single centre clinicopathological review | Journal of Clinical...
Aims: Structured multicentre efforts are needed if the prognosis of adrenocortical carcinoma (ACC) is to be improved. Data collection may be enhanced through standardised histopathological reporting using criteria such as the recently published Royal College of Pathologists (UK) minimum dataset (MDS). This study aimed to perform a clinicopathological review of the adult patients treated at the Royal Victoria Infirmary, Newcastle upon Tyne, in the 10 years preceding the MDS.. Methods: Case records were examined for all patients diagnosed with ACC between 1996 and 2006. Pathology was reviewed and compared with the Royal College of Pathologists MDS along with the original reports. A systematic evaluation of Ki-67 immunolabelling was also performed.. Results: Eleven patients with ACC were diagnosed and treated. Histopathological reporting according to the MDS identified more features of malignancy than in the original reports (8.5±1.2 versus 5.1±0.8, p,0.02). The median number of microscopic ...
http://jcp.bmj.com/content/61/8/939
Clinical management of adrenocortical carcinoma | Medic Debate
Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. Available online 3 June 2009. Adrenocortical carcinoma (ACC) is a rare and ...
http://medicdebate.org/node/512
Adrenocortical Carcinoma | Portsmouth Regional HospitalAdrenocortical Carcinoma | Portsmouth Regional Hospital
Learn more about Adrenocortical Carcinoma at Portsmouth Regional Hospital DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
https://portsmouthhospital.com/hl/?/179661/Adrenal-cancer&com.dotmarketing.htmlpage.language=1
Adrenocortical Carcinoma Research - National Cancer InstituteAdrenocortical Carcinoma Research - National Cancer Institute
Find research articles on adrenocortical carcinoma, which may include news stories, clinical trials, blog posts, and descriptions of active studies.
https://www.cancer.gov/types/adrenocortical/research
Adrenocortical Carcinoma | TriStar Southern HillsAdrenocortical Carcinoma | TriStar Southern Hills
Learn more about Adrenocortical Carcinoma at TriStar Southern Hills DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
https://tristarsouthernhills.com/hl/?/179661/Adrenal-cancer
TCF21/POD-1, a transcritional regulator of SF-1/NR5A1, as a potential prognosis marker in adult and pediatric adrenocortical...TCF21/POD-1, a transcritional regulator of SF-1/NR5A1, as a potential prognosis marker in adult and pediatric adrenocortical...
With recent progress in understanding the pathogenesis of adrenocortical tumors (ACTs), identification of molecular markers to predict their prognosis has become possible. Transcription factor 21 (TCF21)/podocyte-expressed 1 (POD1) is a transcriptional regulatory protein expressed in mesenchymal cells at sites of epithelial-mesenchymal transition during the development of different systems. Adult carcinomas express less TCF21 than adenomas, in addition, the KEGG pathway analysis has shown that BUB1B, among others genes, is negatively correlated with TCF21 expression. The difference between BUB1B and PTEN-induced putative kinase 1 (PINK1) expression has been described previously to be associated with survival in adult but not in pediatric carcinomas. Here, we analyzed the gene expression of TCF21, BUB1B, PINK1, and NR5A1 in adult and pediatric ACTs. We found a negative correlation between the relative expression levels of TCF21 and BUB1B in adult ACTs, but the relative expression levels of TCF21, ...
https://repositorio.butantan.gov.br/handle/butantan/2421
Katie Gerstenberger Endowment: October 2009Katie Gerstenberger Endowment: October 2009
Dr. Park conferred with experts in pathology. She communicated with oncologists at St. Judes Childrens Hospital in Tennessee, where the leading research on adrenocortical carcinoma is being performed by Dr. Rodriguez-Galindo and Dr. Rubiero. They shared their protocol for treating this rare disease with Dr. Park, and she changed Katies chemo regimen to follow the St. Judes teams protocol. Although the most current treatment was given, and the primary tumor was removed after 5 rounds of chemotherapy, the cancer recurred within a few months (in spite of follow-on drug therapy, as well). The thinking about adrenocortical carcinoma is that it is a slow-growing cancer; this was clearly not the case for Katie! Obviously, more needs to be known about pediatric cancer, which is the main reason why Katie wanted her Endowment to fund solid tumor research. Katies preference was that it fund adrenocortical carcinoma research, but since that is such a rare disease, her Endowment funds solid tumor ...
http://katiegerstenbergerendowment.blogspot.com/2009_10_01_archive.html
General Physician for Primary Aldosteronism (Conn Syndrome), Symptoms, Treatment | mfineGeneral Physician for Primary Aldosteronism (Conn Syndrome), Symptoms, Treatment | mfine
Know more about the symptoms, causes, diagnosis and treatment for Primary Aldosteronism (Conn Syndrome). mfine has the finest of General Physician who will provide the best treatment.
https://www.mfine.co/general-physicians/conditions/primary-aldosteronism-
Diagnostic and prognostic value of nucleolar proteins in the regulation of tumor cells proliferation in patients with lung...Diagnostic and prognostic value of nucleolar proteins in the regulation of tumor cells proliferation in patients with lung...
Diagnostic and prognostic value of nucleolar proteins in the regulation of tumor cells proliferation in patients with lung carcinoma and adrenocortical cancer
http://journals.rudn.ru/medicine/article/view/3641
Successful pregnancy following surgery for a masculinizing adrenocortical carcinoma. - Semantic ScholarSuccessful pregnancy following surgery for a masculinizing adrenocortical carcinoma. - Semantic Scholar
A 16-year-old girl with a masculinizing adrenal carcinoma treated surgically is presented. Following surgery a full clinical and steroid remission has been achieved, without any adjuvant chemotherapy. In the 7th year after the surgical treatment the patient became pregnant. Pregnancy and labour were uncomplicated. The patient continues in complete remission, and her son has been noted to have normal development at 21 mth of age.
https://www.semanticscholar.org/paper/Successful-pregnancy-following-surgery-for-a-mascu-Kasperlik-Za%C5%82uska-Migdalska/71f777555d1d2d35bc404a8af516f853bb7a2b3e
In vivo and in vitro effects of AVP and V1a receptor antagonis...In vivo and in vitro effects of AVP and V1a receptor antagonis...
In vivo and in vitro effects of AVP and V1a receptor antagonist on Cushings syndrome due to ACTH-independent bilateral macronodular adrenocortical hyperplasia.
https://www.mysciencework.com/publication/show/vivo-vitro-effects-avp-v1a-receptor-antagonist-cushing-s-syndrome-due-acth-independent-bilateral-macronodular-adrenocor-9060c2fa
WikiGenes - Adrenocortical AdenomaWikiGenes - Adrenocortical Adenoma
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
https://www.wikigenes.org/e/mesh/e/23592.html
Adrenocortical carcinoma staging - wikidocAdrenocortical carcinoma staging - wikidoc
A new study showed staging system that incorporates the patients age better and predicts 5-year survival among patients with stages I/II ACC. Consideration should be given to include age in staging for ACC, because it may better inform providers about treatment and prognosis.[2] ...
http://wikidoc.org/index.php/Adrenocortical_carcinoma_staging
Katie Gerstenberger Endowment: June 2010Katie Gerstenberger Endowment: June 2010
Katies Comforters Guild is listed as one of the guilds that supports cancer research. The guilds connection to cancer research is 1) because Katie died of cancer, 2) our family and friends created the Katie Gerstenberger Endowment for Cancer Research in 2007 and 3) we began our work by sewing quilts for children in the cancer ward at Seattle Childrens Hospital - and weve now expanded to blanket the entire hospital. As you know, Katies endowment is for solid tumor research, to help find a cure for the kind of tumor she had (adrenocortical carcinoma). Since adrenocortical carcinoma is very rare, Katies endowment supports ALL solid tumor research with the income that is generated by the principal in the endowment. At last count, the principal was just over $100,000. ...
http://katiegerstenbergerendowment.blogspot.com/2010_06_01_archive.html
Cintredekin Besudotox (IL-13-PE) for Adrenocortical CarcinomaCintredekin Besudotox (IL-13-PE) for Adrenocortical Carcinoma
This is an open-label Phase 1/2 study to assess the maximum tolerated dose of cintredekin besudotox (IL-13PE, hlLl3-PE38QQR) and the therapeutic respons
http://www.knowcancer.com/cancer-trials/NCT01832974/
Adrenocortical carcinoma screening - wikidocAdrenocortical carcinoma screening - wikidoc
This page was last edited 16:23, 25 September 2017 by Mohammed Medhat. Based on work by Ahmad Al Maradni, Jyostna Chouturi and Aarti Narayan and wikidoc user WikiBot ...
http://wikidoc.org/index.php/Adrenocortical_carcinoma_screening
Conns Syndrome | BetaMedicine
Primary hyperaldosteronism /Conns Syndrome is an adrenal gland disorder which is characterized by overproduction of aldosterone resulting in sodium along
https://betamedicine.com/conns-syndrome/?amp
Cis-Platinum Treatment of Metastatic Adrenal Carcinoma - UCL DiscoveryCis-Platinum Treatment of Metastatic Adrenal Carcinoma - UCL Discovery
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
http://discovery.ucl.ac.uk/56397/
EURORAD - Radiologic Teaching FilesEURORAD - Radiologic Teaching Files
MEN-1, which was first described as a clinical and genetic syndrome by Wermer in 1954, is an autosomal dominant cancer syndrome, characterized primarily by multiple neoplasias in the parathyroid glands, endocrine pancreas and anterior pituitary. Other endocrine tumors such as gastrinoma, carcinoid, adrenal cortical tumors and cutaneous tumors (angiofibroma, collagenoma and lipoma) may also occur. The genetic defect responsible for MEN-1 has been mapped to chromosome 11 q 13 . The MEN-1 gene consists of 10 exons which encodes a protein of 610 amino acids. Inactivation of MEN-1 gene mutations in both germline and sporadic tumors supports that MEN-1 is a tumor-suppessor gene. Germline MEN-1 gene mutation is responsible for the majority of MEN-1 syndrome cases. MEN-1 induces combinations of more than twenty various endocrine and non-endocrine tumors. A feasible definition of MEN-1 is a case with two of the three main MEN-1 related endocrine tumors (parathyroid adenomas, entero-pancreatic endocrine ...
http://www.eurorad.org/eurorad/case.php?id=4303
Vetoryl Rx, 60 mg x 30 ctVetoryl Rx, 60 mg x 30 ct
Vetoryl Capsules are indicated for the treatment of pituitary-dependent hyperadrenocorticism in dogs and for the treatment of hyperadrenocorticism due to adrenocortical tumor in dogs. It is also used for the treatment of Canine Cushings Syndrome. It is an adrenocortical suppressant for oral use in dogs only. Vetoryl is FDA approved. Prescription drugs are NONRETURNABLE and NONREFUNDABLE.
http://www.petsupplies4less.com/Vetoryl-Rx-60-mg-x-30-ct_p_6258.html
Primary Aldosteronism (Conns Syndrome)Primary Aldosteronism (Conns Syndrome)
Psychiatry healthcare professionals gain a thorough knowledge base of psychiatric disorder information to offer the best patient care. Get our FREE app now.
http://www.psychiatryadvisor.com/labmed/primary-aldosteronism-conns-syndrome/article/614206/
Primary Aldosteronism (Conns Syndrome) - Cancer Therapy AdvisorPrimary Aldosteronism (Conns Syndrome) - Cancer Therapy Advisor
Cancer Therapy Advisor provides laboratory medicine specialists with the latest information to correctly diagnose laboratory medicine based upon conditions, procedures and guides. Visit often for updates and new information.
http://www.cancertherapyadvisor.com/labmed/primary-aldosteronism-conns-syndrome/article/614203/
Cabazitaxel Activity in Patients With Advanced AdrenoCortical-Carcinoma Progressing After Previous Chemotherapy Lines |...Cabazitaxel Activity in Patients With Advanced AdrenoCortical-Carcinoma Progressing After Previous Chemotherapy Lines |...
Clinical trial for Adrenocortical carcinoma , Cabazitaxel Activity in Patients With Advanced AdrenoCortical-Carcinoma Progressing After Previous Chemotherapy Lines
https://www.centerwatch.com/clinical-trials/listings/202474/adrenocortical-carcinoma-cabazitaxel-activity-patients-advanced/?section=elg
Adrenal Support: StressAdrenal Support: Stress
Adrenal Support products are designed to support normal adrenal gland function and address symptoms such as fatigue, low-energy, and stress.
https://www.acuatlanta.net/Adrenal-Support-Stress-tid-1-5.html
Zubehör 1.25x objective, Plan Apochromat WD 5 NA 0.04Zubehör 1.25x objective, Plan Apochromat WD 5 NA 0.04
BioTek Product Accessory, Part Number: 1220562, for use with Lionheart FX Vollautomatisiertes Mikroskop , Cytation 7 Multi-Detektions-Reader für Cell Imaging , Cytation C10 Confocal Imaging Reader, Cytation 5 Multi-Detektions-Reader für Cell Imaging , Lionheart LX Vollautomatisiertes Mikroskop and Cytation 1 Multi-Detektions-Reader für Cell Imaging
https://www.biotek.de/de/products/accessories/125x-objective-olympus-na-04/
Adrenocortical adenomaAdrenocortical adenoma
... is commonly described as a benign neoplasm emerging from the cells that comprise the adrenal cortex. ... If functional, adrenocortical adenomas can affect the normal activities of the adrenal cortex. Located within the adrenal ... Hypercortisolism Hyperaldosteronism Hyperandrogenism Adrenal gland Adrenal paraganglioma Adrenal Pheochromocytoma Adrenal ... The adrenal cortex is considered a dynamic organ in which senescent cells are replaced by newly differentiated cells. This ...
https://en.wikipedia.org/wiki/Adrenocortical_adenoma
Laboratory ratLaboratory rat
The most common are adenomas of the pituitary and adenomas/adenocarcinomas of the adrenal cortex in both sexes, mammary gland ... Comparison of Neoplasms in Six Sources of Rats Diamond JM (January 2006). Collapse: How Societies Choose to Fail or Succeed. ... There were even significant variations in the incidences of adrenal medulla tumors among rats from the same source raised in ... The Lewis rat suffers from several spontaneous pathologies: first, they can suffer from high incidences of neoplasms, with the ...
https://en.wikipedia.org/wiki/Laboratory_rat
List of MeSH codes (C19)List of MeSH codes (C19)
MeSH C19.053.098.265 - adrenal cortex neoplasms MeSH C19.053.098.265.500 - adrenocortical adenoma MeSH C19.053.098.265.750 - ... adrenal cortex neoplasms MeSH C19.053.347.500.500 - adrenocortical adenoma MeSH C19.053.347.500.750 - adrenocortical carcinoma ... adrenal cortex neoplasms MeSH C19.344.078.265.500 - adrenocortical adenoma MeSH C19.344.078.265.750 - adrenocortical carcinoma ... ovarian neoplasms MeSH C19.391.630.705.265 - brenner tumor MeSH C19.391.630.705.331 - carcinoma, endometrioid MeSH C19.391. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C19)
Adrenal tumorAdrenal tumor
An adrenal tumor or adrenal mass is any benign or malignant neoplasms of the adrenal gland, several of which are notable for ... The adrenal cortex is composed of three distinct layers of endocrine cells which produce critical steroid hormones. These ... "Adrenal Cortical Neoplasms: Perspectives in Pediatric Patients". In Santulli, Gaetano (ed.). Adrenal Glands: From ... Pheochromocytoma is a neoplasm composed of cells similar to the chromaffin cells of the mature adrenal medulla. ...
https://en.wikipedia.org/wiki/Adrenal_tumor
MEN1MEN1
In rare cases, adrenal cortex tumours are also seen. Most germline or somatic mutations in the MEN1 gene predict truncation or ... The MEN1 phenotype is inherited via an autosomal-dominant pattern and is associated with neoplasms of the pituitary gland, the ... and ependymomas are observed neoplasms. In a study of 12 sporadic carcinoid tumors of the lung, five cases involved ...
https://en.wikipedia.org/wiki/MEN1
List of MeSH codes (C04)List of MeSH codes (C04)
... peritoneal neoplasms MeSH C04.588.322.078 - adrenal gland neoplasms MeSH C04.588.322.078.265 - adrenal cortex neoplasms MeSH ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588.274.120.250.250 - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ... femoral neoplasms MeSH C04.588.149.721 - skull neoplasms MeSH C04.588.149.721.450 - jaw neoplasms MeSH C04.588.149.721.450.583 ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C04)
Oral pigmentationOral pigmentation
... as a result of deficient amounts of hormones being produced from the adrenal cortex. Due to this, dark pigmentation may be ... HIV Antimalarial drug therapy This is an intermediate neoplasm which affects the skin and mucous membranes; usually arising in ... where the infection can lead to destruction of the adrenal gland. Pregnancy[citation needed] Oral contraceptive intake[citation ...
https://en.wikipedia.org/wiki/Oral_pigmentation
Zona reticularisZona reticularis
... is the innermost layer of the adrenal cortex, lying deep to the zona fasciculata and superficial to the adrenal medulla. The ... Coppola, Christopher P.; Merrell, Ronald C. (2001). "Neoplasms of the Adrenal and Endocrine Pancreas in the Elderly". In ... These precursors are not further converted in the adrenal cortex if the cells lack 17β-Hydroxysteroid dehydrogenase. Instead, ... Pediatric Adrenal Insufficiency (Addison Disease) at eMedicine Ibáñez L, Potau N, Marcos MV, de Zegher F (September 1999). " ...
https://en.wikipedia.org/wiki/Zona_reticularis
Adrenal medullaAdrenal medulla
It is located at the center of the gland, being surrounded by the adrenal cortex. It is the innermost part of the adrenal gland ... Neoplasms include: Pheochromocytoma (most common), a catecholamine-secreting tumor of the adrenal medulla Neuroblastoma, a ... The adrenal medulla (Latin: medulla glandulae suprarenalis) is part of the adrenal gland. ... Rather than releasing a neurotransmitter, the cells of the adrenal medulla secrete hormones. The adrenal medulla is the ...
https://en.wikipedia.org/wiki/Adrenal_medulla
Adrenocortical hormoneAdrenocortical hormone
... the adrenocortical hormones are hormones produced by the adrenal cortex, the outer region of the adrenal gland. These ... Low, G., & Sahi, K. (2012). Clinical and imaging overview of functional adrenal neoplasms. International Journal of Urology, 19 ... The glucocorticoid family of hormones is synthesized in the middle layer of the adrenal cortex known as the zona fasciculata. ... Androgens, or sex hormones, are synthesized in the innermost layer of the adrenal cortex known as the zona reticularis. These ...
https://en.wikipedia.org/wiki/Adrenocortical_hormone
Adrenocortical carcinomaAdrenocortical carcinoma
"Diseases of the Adrenal Cortex: Adrenal Cancer". EndocrineWeb. Updated on: 04/14/16 Albano D, Agnello F, Midiri F, Pecoraro G, ... Finally, c-myc gene expression is relatively high in neoplasms, and it is often linked to poor prognosis. Bilateral ... Several relatively rare variants of ACC include:[citation needed] Oncocytic adrenal cortical carcinoma Myxoid adrenal cortical ... which is toxic to cells of the adrenal cortex, as well as standard cytotoxic drugs. A retrospective analysis showed a survival ...
https://en.wikipedia.org/wiki/Adrenocortical_carcinoma
Li-Fraumeni syndromeLi-Fraumeni syndrome
... brain or adrenal cortex) regardless of age at diagnosis A first- or second-degree relative with any cancer diagnosed before age ... Li F.P.; Fraumeni J.F. (October 1969). "Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?". Ann. ... This syndrome is also known as the sarcoma, breast, leukaemia and adrenal gland (SBLA) syndrome. The syndrome is linked to ... The classical LFS malignancies-sarcoma, cancers of the breast, brain, and adrenal glands-comprise about 80% of all cancers that ...
https://en.wikipedia.org/wiki/Li–Fraumeni_syndrome
Adrenal haemorrhageAdrenal haemorrhage
... such as adrenal neoplasm, adrenocortical carcinomas, and pheochromocytomas. Hematomas have solid adrenal nodules, size of which ... The branches then form a sub-capsular plexus within the adrenal cortex, which drains into medullary sinusoids through ... Adrenal crisis Adrenal gland Adrenal insufficiency CT scan Hematoma Hemorrhage Magnetic resonance imaging Traumatic injury ... the viability of residual adrenal tissue, the status of contralateral adrenal gland, and the stability of the patient. Adrenal ...
https://en.wikipedia.org/wiki/Adrenal_haemorrhage
Harrisons Principles of Internal MedicineHarrison's Principles of Internal Medicine
Disorders of the Adrenal Cortex Chapter 380: Pheochromocytoma Chapter 381: Multiple Endocrine Neoplasia Chapter 382: Autoimmune ... Neoplasms of the Lung Chapter 75: Breast Cancer Chapter 76: Upper Gastrointestinal Tract Cancers Chapter 77: Lower ... Polycythemia Vera and Other Myeloproliferative Neoplasms Chapter 100: Acute Myeloid Leukemia Chapter 101: Chronic Myeloid ...
https://en.wikipedia.org/wiki/Harrison's_Principles_of_Internal_Medicine
Mayo ClinicMayo Clinic
They separated and identified compounds from the adrenal cortex that produced cortisone and hydrocortisone. Later in the decade ... "Defect of neuromuscular conduction associated with malignant neoplasms". Am. J. Physiol. 187: 612-613. Gutmann L, Crosby TW, ...
https://en.wikipedia.org/wiki/Mayo_Clinic
Somatostatin receptor 2Somatostatin receptor 2
The Somatostatin receptor 2a was found mostly in far down layers of the cerebral cortex, in the human brain. This variant of ... Kennedy JW, Dluhy RG (1997). "The biology and clinical relevance of somatostatin receptor scintigraphy in adrenal tumor ... "Somatostatin receptor expression indicates improved prognosis in gastroenteropancreatic neuroendocrine neoplasm, and octreotide ... Somatostatin receptor 2a and somatostatin receptor 2b were found in the medulla oblongata, mesencephalon, testis, cortex, ...
https://en.wikipedia.org/wiki/Somatostatin_receptor_2
Glossary of medicineGlossary of medicine
Visual cortex - The visual cortex of the brain is the area of the cerebral cortex that processes visual information. It is ... Adrenal gland - The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones ... Papillary - In oncology, papillary refers to neoplasms with projections ("papillae", from Latin, 'nipple') that have ... The area of the visual cortex that receives the sensory input from the lateral geniculate nucleus is the primary visual cortex ...
https://en.wikipedia.org/wiki/Glossary_of_medicine
Renal cell carcinomaRenal cell carcinoma
Vigorous criticism of Grawitz was provided by Oskar Stoerk in 1908, who considered the adrenal origin of renal tumours to be ... Judd, E. Starr (1929). "Carcinoma of the Renal Cortex with Factors Bearing on Prognosis". Archives of Internal Medicine. 44 (5 ... which is an assessment based on the microscopic morphology of a neoplasm with haematoxylin and eosin (H&E staining). This ... When RCC metastasises, it most commonly spreads to the lymph nodes, lungs, liver, adrenal glands, brain or bones. Immunotherapy ...
https://en.wikipedia.org/wiki/Renal_cell_carcinoma
Long-term effects of alcoholLong-term effects of alcohol
ISBN 978-1-84310-221-2. Uekermann J, Daum I (May 2008). "Social cognition in alcoholism: a link to prefrontal cortex ... pituitary-adrenal axis hormones, beta-endorphin and prolactin in human adults of both sexes". Alcohol and Alcoholism. 37 (2): ... and malignant neoplasms. The psychiatric disorders associated with alcoholism include major depression, dysthymia, ... especially the prefrontal cortex area of the brain. The social skills that are impaired by alcohol use disorder include ...
https://en.wikipedia.org/wiki/Long-term_effects_of_alcohol
Nervi - Viquipèdia, lenciclopèdia lliureNervi - Viquipèdia, l'enciclopèdia lliure
Somatosensory Cortex Repetitive Transcranial Magnetic Stimulation and Associative Sensory Stimulation of Peripheral Nerves ... Schober A, Parlato R, Huber K, Kinscherf R, et al «Cell Loss and Autophagy in the Extra-Adrenal Chromaffin Organ of Zuckerkandl ... Rindi G, Klimstra DS, Abedi-Ardekani B, Asa SL, et al «A common classification framework for neuroendocrine neoplasms: an ... Păun, DL; Mirică, A «Pheochromocytomas and Paragangliomas: A Focus on Genetics» (en anglès). A: Clinical Management of Adrenal ...
https://ca.m.wikipedia.org/wiki/Innervació
Adrenal Carcinoma Guidelines: Guidelines SummaryAdrenal Carcinoma Guidelines: Guidelines Summary
Adrenal cortical neoplasms in children: why so many carcinomas and yet so many survivors?. Pediatr Dev Pathol. 2009 Jul-Aug. 12 ... Adrenal Cortex. Brierley JD, Gospodarowicz MK, Wittekind C, eds. TNM Classification of Malignant Tumours. 8th ed. Hoboken, NJ: ... Adrenal wash-out CT: moderate diagnostic value in distinguishing benign from malignant adrenal masses. Eur J Endocrinol. 2021 ... encoded search term (Adrenal Carcinoma) and Adrenal Carcinoma What to Read Next on Medscape ...
https://emedicine.staging.medscape.com/article/276264-guidelines
HuGE Navigator|HuGE Literature Finder|PHGKBHuGE Navigator|HuGE Literature Finder|PHGKB
No article was found for Adrenal Cortex Neoplasms and MEN1[original query]. ...
https://phgkb.cdc.gov/PHGKB/searchSummary.action?firstQuery=Adrenal Cortex Neoplasms and MEN1&Mysubmit=Search
1988 OSHA PEL Project - Hexachlorobutadiene | NIOSH | CDC1988 OSHA PEL Project - Hexachlorobutadiene | NIOSH | CDC
... and damage to kidney tissue and the adrenal cortex after two 4-hour exposures at 250 ppm; twelve 6-hour exposures to 100 ppm ... 1-494). These authors also reported that HCBD-induced neoplasms occur only at HCBD doses higher than those causing discernible ... and renal neoplasms, all of which constitute material health impairments that are associated with exposure to HCBD at levels ... renal neoplasms) result from ingestion of 20 mg/kg/day (Kociba, Schwetz, Keyes et al. 1977/Ex. ...
https://www.cdc.gov/niosh/pel88/87-68.html
HuGE Navigator|Genopedia|PHGKBHuGE Navigator|Genopedia|PHGKB
A00 0 Cholera CholeraA00 0 Cholera Cholera
Malignant neoplasm of adrenal gland 02068 C740 0 Malignant neoplasm of cortex of adrenal gland Malignant neoplasm of cortex of ... 1 Malignant neoplasm of cortex of left adrenal gland Malignant neoplasm of cortex of left adrenal gland 02072 C741 0 Malignant ... Malignant neoplasm of cortex of unspecified adrenal gland 02070 C7401 1 Malignant neoplasm of cortex of right adrenal gland ... 1 Benign neoplasm of right adrenal gland Benign neoplasm of right adrenal gland 03202 D3502 1 Benign neoplasm of left adrenal ...
https://ftp.cdc.gov/pub/Health_Statistics/NCHS/Publications/ICD10CM/2021/icd10cm_order_2021.txt
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No article was found for Adrenal Cortex Neoplasms and HLA-DRB1[original query]. ...
https://phgkb.cdc.gov/PHGKB/searchSummary.action?firstQuery=Adrenal Cortex Neoplasms and HLA-DRB1&Mysubmit=search
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No article was found for Adrenal Cortex Neoplasms and AXIN2[original query]. ...
https://phgkb.cdc.gov/PHGKB/searchSummary.action?firstQuery=Adrenal Cortex Neoplasms and AXIN2&Mysubmit=Search
Amyloidosis: Definition of Amyloid and Amyloidosis, Classification Systems, Systemic AmyloidosesAmyloidosis: Definition of Amyloid and Amyloidosis, Classification Systems, Systemic Amyloidoses
The accumulation of amyloid-β peptide (Aβ) in the brain both in the form of plaques in the cerebral cortex and in blood vessel ... Other organs involved include the heart, gastrointestinal tract, liver, lungs, prostate, adrenals, and tongue. ... and occasionally with neoplasms; it was formerly termed secondary amyloidosis.. Worldwide, AA is the most common systemic ...
https://www.staging.medscape.com/answers/335414-105992/how-is-transthyretin-amyloidosis-diagnosed-and-treated
A Novel Therapeutic Vaccine (EO2401) in Metastatic Adrenocortical Carcinoma, or Malignant Pheochromocytoma/Paraganglioma - Full...A Novel Therapeutic Vaccine (EO2401) in Metastatic Adrenocortical Carcinoma, or Malignant Pheochromocytoma/Paraganglioma - Full...
Adrenal Cortex Neoplasms. Adrenal Gland Neoplasms. Endocrine Gland Neoplasms. Neoplasms by Site. Adrenal Cortex Diseases. ... Neoplasms by Histologic Type. Neoplasms. Neuroendocrine Tumors. Neuroectodermal Tumors. Neoplasms, Germ Cell and Embryonal. ... Three to 12 evaluable patients with adrenal carcinoma or progressive malignant pheochromocytoma/paraganglioma will be included ...
https://clinicaltrials.gov/ct2/show/NCT04187404?term=spencer&draw=2&rank=2
Surgical Resection of Synchronously Metastatic Adrenocortical Cancer<...
Adrenal Cortex Neoplasms Medicine & Life Sciences 100% * Adrenocortical Carcinoma Medicine & Life Sciences 25% ... Methods: A review of all patients undergoing surgery (European Network for the Study of Adrenal Tumors) stage IV ACC between ... European Network for the Study of Adrenal Tumors) stage IV ACC between January 2000 and December 2012 from two referral centers ... European Network for the Study of Adrenal Tumors) stage IV ACC between January 2000 and December 2012 from two referral centers ...
https://mayoclinic.pure.elsevier.com/en/publications/surgical-resection-of-synchronously-metastatic-adrenocortical-can
Abstract for TR-520Abstract for TR-520
Neoplasms of the adrenal cortex and cholangioma of the liver may have been related to administration of PCB 126. ... At 2 years, adenomas and/or carcinomas were present in the adrenal cortex of most core study groups and in the 1,000 ng/kg stop ... Dose-related effects on the incidences of adrenal cortex atrophy and cytoplasmic vacuolization were also seen. ... PCB 126 administration caused increased incidences of nonneoplastic lesions of the liver, lung, adrenal cortex, pancreas, ...
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr520/index.html?utm_source=direct&utm_medium=prod&utm_campaign=ntpgolinks&utm_term=9301
Biochemistry of Human Cancer - 1st EditionBiochemistry of Human Cancer - 1st Edition
12 Neoplasms of the Adrenal Cortex. I. Introduction. II. Steroids of the Adrenal Cortex. III. Cushings Syndrome. IV. The ... Neoplasms of the Stomach. III. Neoplasms of the Small Intestine. IV. Neoplasms of the Colon and Rectum. V. Neoplasms of the ... and neoplasms of other organs, such as the pituitary gland, thyroid, testis, and adrenal cortex. Brief case reports from the ... 15 Neoplasms of the Ovary. I. Introduction. II. Biochemistry of the Normal Ovary. III. Biochemistry of Ovarian Neoplasms. ...
https://www.elsevier.com/books/biochemistry-of-human-cancer/bodansky/978-0-12-109850-6
118948005 - Disorder of abdomen - SNOMED CT
Malignant tumor of adrenal cortex 363479004 removed: 2002-07-31. *Metal foreign body in abdomen 283170002 ... Neoplasm of abdomen 128050000. *Obstructed labor due to abnormality of maternal pelvic organs 199765007 ...
https://www.findacode.com/snomed/118948005--disorder-of-abdomen.html
Glucocorticoid Therapy and Cushing Syndrome: Background, Pathophysiology, Endogenous Cushing syndromeGlucocorticoid Therapy and Cushing Syndrome: Background, Pathophysiology, Endogenous Cushing syndrome
... of the adrenal cortex and adrenocortical neoplasms that result in autonomous overproduction of cortisol and other adrenal ... Adrenal neoplasms. For nonmalignant adrenal neoplasms, the cure rate remains excellent. For malignant tumors, surgery offers ... The adrenal cortex. In: Wilson JD, Foster DW, Kronenberg H, Larsen PR, eds. Williams Textbook of Endocrinology. 9th ed. ... Adrenal neoplasm. Personal or family history of multiple tumors (eg, lung, breast, nasopharynx, CNS, melanoma, pancreas, gonads ...
https://emedicine.medscape.com/article/921086-overview
Dissecting morphological and molecular heterogeneity in adrenocortical carcinomaDissecting morphological and molecular heterogeneity in adrenocortical carcinoma
Adrenocortical carcinoma; Heterogeneity; Immunohistochemistry; Molecular pathology; Variants; Adrenal Cortex Neoplasms; ... as it is currently approached for other types of neoplasms such as breast or lung cancer, which are not merely descriptive, but ... as it is currently approached for other types of neoplasms such as breast or lung cancer, which are not merely descriptive, but ... Neoplasm Grading; Pathology, Molecular; Phenotype; Predictive Value of Tests; Biomarkers, Tumor; 2734; Medicine (all) ...
https://iris.unito.it/handle/2318/1570737
HuGE Navigator|HuGE Literature Finder|PHGKBHuGE Navigator|HuGE Literature Finder|PHGKB
No article was found for Adrenal Cortex Neoplasms and BRAF[original query]. ...
https://phgkb.cdc.gov/PHGKB/searchSummary.action?firstQuery=Adrenal%20Cortex%20Neoplasms+and+BRAF&Mysubmit=Search
Androgen Excess Clinical Presentation: History, Physical, CausesAndrogen Excess Clinical Presentation: History, Physical, Causes
Androgens are produced primarily from the adrenal glands and the ovaries. ... Androgen-secreting adrenal neoplasms are less common than ovarian neoplasms. [62] Patients with these tumors usually present ... Elevated prolactin levels might directly stimulate the adrenal cortex. [65] Pregnancy. Testosterone rises throughout the normal ... Other cases of Cushing syndrome are related to autonomous cortisol secretion by the adrenal glands. [60] Adrenal tumors are ...
https://www.medscape.com/answers/273153-91122/what-is-the-role-of-congenital-adrenal-hyperplasia-in-the-etiology-of-androgen-excess
HuGE Navigator|Genopedia|PHGKBHuGE Navigator|Genopedia|PHGKB
DeCSDeCS
Adrenal Cortex Neoplasm Neoplasm, Adrenal Cortex Neoplasms, Adrenal Cortex Adrenocortical Cancer - Narrower Concept UI. ... Cancers, Adrenal Cortex. Cancers, Adrenocortical. Neoplasm, Adrenal Cortex. Neoplasms, Adrenal Cortex. Tree number(s):. C04.588 ... Adrenal Cortex Cancer Adrenal Cortex Cancers Adrenocortical Cancers Cancer of Adrenal Cortex Cancer of the Adrenal Cortex ... Adrenal Cortex Neoplasm. Adrenocortical Cancer. Adrenocortical Cancers. Cancer of Adrenal Cortex. Cancer of the Adrenal Cortex ...
https://decs.bvsalud.org/en/ths/resource/?id=309&filter=ths_exact_term&q=NEOPLASIAS+DO+C%C3%93RTEX+SUPRARRENAL
IMSEAR at SEARO: Non-functioning adrenal cortical carcinoma.
Adrenal Cortex Neoplasms. en_US. dc.subject.mesh. Adrenal Gland Neoplasms. en_US. ... Thusoo TK, Gulati SM, Pandey KK, Satyanand . Non-functioning adrenal cortical carcinoma. Indian Journal of Cancer. 1977 Dec; 14 ...
https://imsear.searo.who.int/handle/123456789/50202?mode=full
Hyperaldosteronism; AldosteronismHyperaldosteronism; Aldosteronism
Adrenal Cortex Neoplasms. 12. + + 6. Adrenal Gland Neoplasms. 10. + + 7. Adenoma. 8. + + ...
https://lookfordiagnosis.com/results.php?symptoms=Hyperaldosteronism%3B%20Aldosteronism&lang=1&parent=%2F&mode=F
Code System Concept
Neoplasm of adrenal cortex (disorder). Code System Preferred Concept Name. Neoplasm of adrenal cortex (disorder). ... Neoplasm of adrenal cortex Active Synonym false false 474007017 Tumor of adrenal cortex Active Synonym false false ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=127022002
Agriculture & FarmingAgriculture & Farming
Adrenal Cortex Neoplasms Market DelveInsights Adrenal Cortex Neoplasms Market Insights, Epidemiology, and Market Forecast-2032 ... Adrenal Cortex Neoplasms Market Size and Trends, Epidemiology, Industry Analysis, Drugs, Pipeline, Treatment and Key Companies ...
http://www.srinagarmagazine.in/category/agriculture-farming
Albumin FS - PROLINEAlbumin FS - PROLINE
Adrenal cortex insufficiency. *Hypopituitarism. *Extra - pancreatic neoplasm. *Severe liver disease. *Alcohol consumption ...
https://proline.co.id/our-product/reagents/clinical-chemistry/albumin-fs/
ARCHS4ARCHS4
Neoplasm of the adrenal cortex (HP:0100641). 1.90008900. 59. Abnormality of the vitamin B12 metabolism (HP:0004341). 1.89810841 ...
https://maayanlab.cloud/archs4/gene/UGT8
Genevisible - Top 10 cancers for 1553102 a at
... adrenal cortical adenoma, NOS, cortex of adrenal gland, adrenal gland, chronic lymphocytic leukemia, B-cell type ... cortex of adrenal gland. Expression (log2-scale):14.389032. Number of Samples:190 Neoplasm. cortex of adrenal gland. ... Neoplasm. cortex of adrenal gland, adrenal cortical adenoma, NOS. Hierarchy. neoplasms of endocrine glands and related ... cortex of adrenal gland, adrenal cortical adenoma, NOS. Expression (log2-scale):14.483707. Number of Samples:80 ...
https://genevisible.com/cancers/HS/Affymetrix%20Probeset/1553102_a_at
Pesquisa | Prevenção e Controle de CâncerPesquisa | Prevenção e Controle de Câncer
ACC is a rare malignant neoplasm of the adrenal cortex with a variable prognosis. At present, predicting the course of the ... Adrenal cortex produces glucocorticoids, mineralocorticoids and adrenal androgens which are essential for life, supporting ... we will summarize our knowledge on the mechanisms regulating adrenal cortex development and function, describe adrenal ... One hypothesis is that changes in vascular supply to the adrenal cortex, due to phenomena of atherosclerosis or high blood ...
https://pesquisa.bvsalud.org/controlecancer/?lang=pt&q=mh:Neoplasias+do+C%C3%B3rtex+Suprarrenal/patologia
DeCS 2008 - versión 17 de Marzo de 2008DeCS 2008 - versión 17 de Marzo de 2008
Cancer of Adrenal Cortex use Adrenal Cortex Neoplasms. Cancer of Anus use Anus Neoplasms ...
https://decs.bvs.br/I/DeCS2008_Alfab-C_ing.htm
BIGG
Adrenal Cortex Neoplasms, Neoplasm Metastasis, Antineoplastic Agents, Hormonal/therapeutic use, Etoposide/administration & ... Hydrocortisone, Adrenal Gland Neoplasms, Incidental Findings, Adrenal Gland Neoplasms/therapy, Adrenal Gland Neoplasms/ ... By definition, an adrenal incidentaloma is an asymptomatic adrenal mass detected on imaging not performed for suspected adrenal ... Adrenal Cortex Neoplasms/therapy, Adrenocortical Carcinoma/therapy, Chemoembolization, Therapeutic ...
https://sites.bvsalud.org/bigg/en/biblio/?filter=publication_country:en^Norway|pt-br^Noruega|es^Noruega
Pełny tekst: Funkcjonowanie nadnerczy u pacjentów pediatrycznych podczas leczenia onkologicznego i po jego zakończeniu, Barbara...Pełny tekst: Funkcjonowanie nadnerczy u pacjentów pediatrycznych podczas leczenia onkologicznego i po jego zakończeniu, Barbara...
Mitotane is an anti-cancer drug used to treat adrenal cortex cancer. It directly influences the adrenal cortex by inhibiting ... There are some therapeutics that are dedicated to treat adrenal neoplasms, but they affect adrenal function. ... Aminoglutethimide is an anti-cancer drug used in the treatment of breast cancer, prostate cancer, and adrenal cortex cancer. It ... One of the first indications that there is adrenal cortex dysfunction is an elevation in plasma renin level [35]. Therefore, ...
https://www.termedia.pl/Funkcjonowanie-nadnerczy-u-pacjentow-pediatrycznych-podczas-leczenia-onkologicznego-i-po-jego-zakonczeniu,138,47553,1,0.html
G0S2 Lysates: Novus BiologicalsG0S2 Lysates: Novus Biologicals
Lung Neoplasms (1). *. Malignant Neoplasm Of Adrenal Cortex (1). *. Malignant Neoplasm Of Lung (1) ...
https://www.novusbio.com/lysates/g0s2?related_diseases=Malignant%20Neoplasm%20Of%20Lung
Terminal RI - SophiA Biblioteca WebTerminal RI - SophiA Biblioteca Web
Abstract: The adrenocortical carcinoma (ACC) is a rare malignant neoplasm that appears in the adrenal cortex. The main ... Abstract: The adrenocortical carcinoma (ACC) is a rare malignant neoplasm that appears in the adrenal cortex. The main ...
https://www.repositorio.unicamp.br/acervo/detalhe/918172
Adrenocortical carcinomaAdrenocortical carcinoma
C74.90 - Malignant neoplasm of adrenal gland. SNOMEDCT:. 255035007 - Adrenal carcinoma. Best Tests. Subscription Required ... A malignant tumor of the adrenal cortex. Adrenal carcinomas may be found incidentally on imaging or may be identified after a ... About half of adrenal carcinomas do not produce hormones, while the other half produce any combination of the normal adrenal ... Post-contrast MRI of the abdomen demonstrates heterogeneously enhancing right adrenal mass.. +4 More images of Adrenocortical ...
https://logicalimages.com/visualdx/diagnosis/adrenocortical+carcinoma?moduleId=101&diagnosisId=55630
Evaluation of 18F-AlF-NOTA-octreotide for imaging neuroendocrine neoplasms: comparison with 68Ga-DOTATATE PET/CT | EJNMMI...Evaluation of 18F-AlF-NOTA-octreotide for imaging neuroendocrine neoplasms: comparison with 68Ga-DOTATATE PET/CT | EJNMMI...
Twenty patients (mean age: 52.65 years, range: 24-70 years) with biopsy-proven neuroendocrine neoplasms (NENs) were ... cerebral cortex, adrenal gland, uncinate process of the pancreas (PU), pancreas (except the PU), stomach, spleen, thyroid, ... Hou, J., Long, T., He, Z. et al. Evaluation of 18F-AlF-NOTA-octreotide for imaging neuroendocrine neoplasms: comparison with 68 ... Evaluation of 18F-AlF-NOTA-octreotide for imaging neuroendocrine neoplasms: comparison with 68Ga-DOTATATE PET/CT. *Jiale Hou1 ...
https://ejnmmires.springeropen.com/articles/10.1186/s13550-021-00797-4
New Drugstore: Safety of crestor original quality!
With 95% ci 0.5 3.2), 6) of the palpable tumors are heterogeneous neoplasms. 159 8. Adrenal cortex resulting from pelvic in the ...
https://vgdev.gtorg.gatech.edu/buyonline/safety-of-crestor/1/
TumorsProstatic neoplasmsHormonesGlandsMedullaInsufficiencyPancreatic neoplasmCongenital adrenal hypHypothalamic-pituitary-adrenalMalignant neoplasmMetastaticCortical carcinomaTumorNeuroendocrine neoplasmsGlandBenignHuman adrenalHeterogeneousMitotaneAdrenocortical adenomasEndocrineEpidemiologyPheochromocytomaClassificationCancerAndrogenHYPERPLASIAGlandularAxisCancersDiseaseDifferencesMassPatients
Tumors11
  • Methods: A review of all patients undergoing surgery (European Network for the Study of Adrenal Tumors) stage IV ACC between January 2000 and December 2012 from two referral centers was performed. (elsevier.com)
  • Biochemistry of Human Cancer focuses on advances in the application of biochemistry to the study of human cancers, such as neoplastic immunoglobulinopathies, cancer of the bladder, tumors of the neural crest, leukemias and lymphomas, and neoplasms of the bone. (elsevier.com)
  • The remaining chapters look at the role of enzymes and immunoglobulins in cancer, the tryptophan metabolism in cancer of the bladder and the carcinoid syndrome, the link between amino acid metabolism and tumors of the neural crest, and the neoplasms of the digestive tract and the accessory organs (pancreas and liver). (elsevier.com)
  • Tumors or cancers of the ADRENAL CORTEX . (bvsalud.org)
  • The impact of genetics and genomics on clinical medicine is becoming more and more important Endocrinology pioneered the development of molecular medicine, but also the study of adrenal tumors had a great impact in this field. (elsevier.com)
  • Particularly important was the detection of genetics of tumors derived from the adrenal medulla, as well as that of those derived from the sympathetic and parasympathetic paraganglia. (elsevier.com)
  • Less well understood is the genetics of adrenal cortex tumors, in particular adrenocortical carcinoma, a rare and particularly aggressive disease. (elsevier.com)
  • Adrenal cancer is a rare and heterogenous group of tumors the etiology of which is largely unknown. (semanticscholar.org)
  • DESIGN: Expression of PSMA was evaluated in benign and malignant adrenal tumors and 1 patient with metastatic ACC. (cornell.edu)
  • CONCLUSIONS: PSMA is significantly overexpressed in ACC neovasculature when compared with normal and benign adrenal tumors. (cornell.edu)
  • In cytology, the practical utility of immunocytochemistry includes characterization of poorly differentiated neoplasms, differentiation of primary from metastatic tumors, determination of the sites of origin of metastatic lesions and prognostic assessments. (basicmedicalkey.com)
Prostatic neoplasms1
  • It then discusses the important biochemical aspects of pulmonary and prostatic neoplasms, including the serum acid and alkaline phosphatase activities of prostatic carcinoma. (elsevier.com)
Hormones2
  • About half of adrenal carcinomas do not produce hormones, while the other half produce any combination of the normal adrenal cortical hormones. (logicalimages.com)
  • The most relevant hormones for the neuroendocrine axis are the adrenocorticotropic hormone (ACTH) and ß-endorphins, which stimulate the secretion of various endogenous substances, such as glucocorticoids, produced in the adrenal cortex, and noradrenaline and adrenaline, produced in the adrenal medulla and nerve endings 5-7 . (bvsalud.org)
Glands4
  • Hull B, Wedrychowicz A. The function of adrenal glands in children and adolescents during and after oncological treatment. (termedia.pl)
  • Cortisol is produced mainly by the adrenal cortex (the outer part of the two adrenal glands, located above the kidneys). (biosteroids.com)
  • PATIENTS: Fifty adrenal samples were evaluated, including 16 normal adrenal glands, 16 adrenocortical adenomas, 15 primary ACC, and 3 ACC metastases. (cornell.edu)
  • Once excited, the PVN produces the neuropeptide corticotropin-releasing factor (CRF), which travels through the hypophyseal portal system and stimulates the adrenal and pituitary glands to produce many neurotransmitters. (bvsalud.org)
Medulla1
  • Glucocorticoid synthesis and release is strictly regulated by the pituitary and hypothalamus by negative feedback and, to a lesser extent, by catecholamines from the adrenal medulla and neural inputs from the autonomic system. (medscape.com)
Insufficiency2
  • Although uncommon, the adrenal insufficiency can be a life-threatening complication of the cancer treatment. (termedia.pl)
  • Triamcinolone is used as an alternative treatment for adrenal insufficiency. (firedrug.com)
Pancreatic neoplasm1
  • Stock C, Keutgen XM, Pisapia D, Crawford C, Zarnegar R. Heterotopic pancreatic neoplasm presenting as an obstructing mass at the fourth portion of the duodenum. (rush.edu)
Congenital adrenal hyp5
  • [ 34 ] Congenital adrenal hyperplasia also presents with familial clustering. (medscape.com)
  • The 17-hydroxyprogesterone (17-OHP) test is routinely ordered as part of newborn screening in the UnitedStates to detect congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. (biosteroids.com)
  • Cortisol is called the 'stress hormone' because it's secreted in larger amounts as part of the body's response to physical or emotional stress.In kids, the most common cause of cortisol deficiency, and consequently high levels of 17-hydroxyprogesterone, is one of the forms of the genetic disorder congenital adrenal hyperplasia (CAH). (biosteroids.com)
  • 17-hydroxyprogesterone is elevated in patients with congenital adrenal hyperplasia (CAH). (biosteroids.com)
  • Triamcinolone is also effective in congenital adrenal hyperplasia of cerebral edema and rheumatic diseases. (firedrug.com)
Hypothalamic-pituitary-adrenal3
  • Although distinguishing endogenous from exogenous Cushing syndrome is usually straightforward, the investigation and differentiation of Cushing syndrome from other causes of hypercortisolism require a sound understanding of the physiology of the hypothalamic-pituitary-adrenal (HPA) axis. (medscape.com)
  • Chemotherapy, as well as radiotherapy of the head, neck and abdomen area, may interfere temporarily or permanently with the proper functioning of the hypothalamic pituitary adrenal axis (HPAA). (termedia.pl)
  • The hypothalamic-pituitary-adrenal (HPA) axis is responsible for many body functions in mammals. (bvsalud.org)
Malignant neoplasm2
  • Abstract: The adrenocortical carcinoma (ACC) is a rare malignant neoplasm that appears in the adrenal cortex. (unicamp.br)
  • carcinoma - Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell c. (en-academic.com)
Metastatic2
  • A case of metastatic adrenal cancer: with a statistical analysis based on annals of the pathological autopsy cases in Japan in the past 5 years]. (semanticscholar.org)
  • Of note, longitudinal sampling of primary and metastatic thyroid neoplasms was crucial for refining tumor classification and coining the recently-described non-invasive follicular thyroid neoplasm with papillary-like nuclear features(Nikiforov et al. (biomedcentral.com)
Cortical carcinoma1
  • IMSEAR at SEARO: Non-functioning adrenal cortical carcinoma. (who.int)
Tumor5
  • Furthermore, immunohistochemical and molecular studies, based on a wide set of different methodologies, identified novel biomarkers in adrenocortical carcinoma of diagnostic and prognostic relevance, which claimed again the concept that this tumor type represents an heterogeneous group of neoplasms which cannot be considered a unique entity. (unito.it)
  • BACKGROUND: Adrenocortical cancer (ACC) is an orphan malignant tumor of the adrenal cortex with a predominantly poor prognosis and an aggressive clinical course. (bvsalud.org)
  • A malignant tumor of the adrenal cortex. (logicalimages.com)
  • Neuroendocrine neoplasms (NENs) are a relatively rare and highly heterogeneous tumor derived from neuroendocrine cells. (springeropen.com)
  • INTRODUCCIÓN: Prostatectomía por laparoscopia es una técnica quirúrgica que se utiliza para extirpar un tumor de próstata localizado en el interior de la glándula o para extirpar la próstata por completo. (bvsalud.org)
Neuroendocrine neoplasms2
  • Twenty patients (mean age: 52.65 years, range: 24-70 years) with biopsy-proven neuroendocrine neoplasms (NENs) were enrolled in this prospective study. (springeropen.com)
  • It's clear that most hereditary and familial Neuroendocrine Neoplasms (NEN) will be from well-differentiated Neuroendocrine Tumours (NET) rather than poorly differentiated Neuroendocrine Carcinomas (NEC). (ronnyallan.net)
Gland1
  • The book explains the metabolism of purines and pyrimidines in cancer, hypercalcemia in neoplastic disease without evidence of bone metastases, and neoplasms of other organs, such as the pituitary gland, thyroid, testis, and adrenal cortex. (elsevier.com)
Benign1
  • Uterine leiomyoma is the most common benign neoplasm of the female genital tract. (gafacom.website)
Human adrenal3
  • Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway. (semanticscholar.org)
  • Epigallocatechin gallate induced apoptosis in human adrenal cancer NCI-H295 cells through caspase-dependent and caspase-independent pathway. (semanticscholar.org)
  • Mice have largely been overlooked as a model system for the human adrenal as mouse adrenals are unable to produce androgens due to the silencing of Cyp17a1 early in development. (nature.com)
Heterogeneous1
  • Adrenal cancer is a heterogeneous group of neoplasms with unknown etiology. (semanticscholar.org)
Mitotane1
  • Treatment modalities include surgery, medical adrenal suppression (mitotane), and cytotoxic chemotherapy. (logicalimages.com)
Adrenocortical adenomas1
  • In most cases, adrenal incidentalomas are nonfunctioning adrenocortical adenomas, but may also represent conditions requiring therapeutic intervention (e.g. adrenocorti. (bvsalud.org)
Endocrine3
  • Adrenal carcinomas may be found incidentally on imaging or may be identified after a patient shows signs of endocrine dysfunction, such as hypercortisolism or virilization. (logicalimages.com)
  • Syndromes such as multiple endocrine neoplasia type 1 are uncommonly the cause of adrenal carcinoma. (logicalimages.com)
  • Previous global knockouts have ablated AR from the adrenal 21 , however, the caveats of this, like many global knockout models, is that the adrenals both produce and respond to multiple endocrine stimuli. (nature.com)
Epidemiology1
Pheochromocytoma1
  • Three to 12 evaluable patients with adrenal carcinoma or progressive malignant pheochromocytoma/paraganglioma will be included depending on the safety profile of the administered treatments. (clinicaltrials.gov)
Classification2
  • The integration between morphology, immunophenotype and molecular data is expected in the next years to build a novel concept of adrenocortical carcinoma classification into specific subgroups, as it is currently approached for other types of neoplasms such as breast or lung cancer, which are not merely descriptive, but also characterized by a specific biological and clinical behavior. (unito.it)
  • Skin neoplasm - Skin cancer Classification and external resources A basal cell carcinoma. (en-academic.com)
Cancer3
  • Management of patients with adrenal cancer: recommendations of an international consensus conference. (semanticscholar.org)
  • SummaryMitotane is an important adrenalytic drug for the treatment of adrenal cancer whose use is limited by toxicity. (semanticscholar.org)
  • Smoking and adrenal cancer mortality among United States veterans. (semanticscholar.org)
Androgen5
  • Rapid virilization associated with hirsutism is suggestive of androgen secreting neoplasm or exogenous androgenic drug use. (medscape.com)
  • Androgen receptor (AR) is widely expressed throughout the adrenal cortex, yet the wider role for androgen signalling in the adrenal remains underexplored. (nature.com)
  • To investigate AR-dependent and AR-independent androgen signalling in the adrenal, we used a novel mouse model with a specific ablation of androgen receptor in the adrenal cortex with or without reduction of circulating androgen levels by castration. (nature.com)
  • Our results describe AR expression in the human and mouse adrenal and highlight that the mouse is a viable model to investigate androgen signalling in the adrenal cortex. (nature.com)
  • The redevelopment of the X-zone following castration and the abundant expression of AR in the mouse adrenal suggests that androgens are important regulators of the adrenal cortex and that despite not producing adrenal androgens, the mouse has utility for dissecting the role of androgen signalling within the adrenal. (nature.com)
HYPERPLASIA1
  • Additionally, investigation of aged mice with AR ablation reveals severe cortex disruption, spindle cell hyperplasia and X-zone expansion. (nature.com)
Glandular1
  • 1981). By immunohistochemical techniques TGF-β1 was strongly detected in adrenal cortex, megakaryocytes and other bone marrow cells, cardiac myocytes, chondrocytes, renal distal tubules, ovarian glandular cells and chorionic cells of the placenta and also in cartilage, heart, pancreas, skin, and uterus (Thompson et al. (atlasgeneticsoncology.org)
Axis1
  • Moreover, we present diagnostic guidelines for the evaluation of the function of the adrenal axis and we report available protocols for the management of its disturbances. (termedia.pl)
Cancers1
  • We present possible adrenal complications in the most frequent pediatric cancers. (termedia.pl)
Disease2
  • Addison disease presents as adrenal cortical hypofunction along with splotchy or generalized bronzing of the mucosa and skin. (medscape.com)
  • By definition, an adrenal incidentaloma is an asymptomatic adrenal mass detected on imaging not performed for suspected adrenal disease. (bvsalud.org)
Differences1
  • Furthermore, cortex measurements define differences in X-zone morphology depending on whether circulating androgens or AR have been removed. (nature.com)
Mass1
  • Post-contrast MRI of the abdomen demonstrates heterogeneously enhancing right adrenal mass. (logicalimages.com)
Patients1
  • Cohorts 2A (previously treated patients) and 2B (previously untreated patients): evaluation of EO2401 at the recommended dose found in Cohort 1 in combination with nivolumab in 30 evaluable patients (15 each for Cohorts 2A and 2B) with adrenal carcinoma. (clinicaltrials.gov)
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