Adp ribosylation factors. Medical search

MONOMERIC GTP-BINDING PROTEINS that were initially recognized as allosteric activators of the MONO(ADP-RIBOSE) TRANSFERASE of the CHOLERA TOXIN catalytic subunit. They are involved in vesicle trafficking and activation of PHOSPHOLIPASE D. This enzyme was formerly listed as EC 3.6.1.47

ADP-RIBOSYLATION FACTOR 1 is involved in regulating intracellular transport by modulating the interaction of coat proteins with organelle membranes in the early secretory pathway. It is a component of COAT PROTEIN COMPLEX I. This enzyme was formerly listed as EC 3.6.1.47.

A fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity.

Vesicles formed when cell-membrane coated pits (COATED PITS, CELL-MEMBRANE) invaginate and pinch off. The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS.

A 700-kDa cytosolic protein complex consisting of seven equimolar subunits (alpha, beta, beta', gamma, delta, epsilon and zeta). COATOMER PROTEIN and ADP-RIBOSYLATION FACTOR 1 are principle components of COAT PROTEIN COMPLEX I and are involved in vesicle transport between the ENDOPLASMIC RETICULUM and the GOLGI APPARATUS.

Protein factors that promote the exchange of GTP for GDP bound to GTP-BINDING PROTEINS.

Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.

A protein complex comprised of COATOMER PROTEIN and ADP RIBOSYLATION FACTOR 1. It is involved in transport of vesicles between the ENDOPLASMIC RETICULUM and the GOLGI APPARATUS.

A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)

Proteins that activate the GTPase of specific GTP-BINDING PROTEINS.

An ester formed between the aldehydic carbon of RIBOSE and the terminal phosphate of ADENOSINE DIPHOSPHATE. It is produced by the hydrolysis of nicotinamide-adenine dinucleotide (NAD) by a variety of enzymes, some of which transfer an ADP-ribosyl group to target proteins.

An enzyme found mostly in plant tissue. It hydrolyzes glycerophosphatidates with the formation of a phosphatidic acid and a nitrogenous base such as choline. This enzyme also catalyzes transphosphatidylation reactions. EC 3.1.4.4.

Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes.

Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.

Esters formed between the aldehydic carbon of sugars and the terminal phosphate of adenosine diphosphate.

Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

A pentose active in biological systems usually in its D-form.

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.

Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains.

Transport proteins that carry specific substances in the blood or across cell membranes.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.

A set of BACTERIAL ADHESINS and TOXINS, BIOLOGICAL produced by BORDETELLA organisms that determine the pathogenesis of BORDETELLA INFECTIONS, such as WHOOPING COUGH. They include filamentous hemagglutinin; FIMBRIAE PROTEINS; pertactin; PERTUSSIS TOXIN; ADENYLATE CYCLASE TOXIN; dermonecrotic toxin; tracheal cytotoxin; Bordetella LIPOPOLYSACCHARIDES; and tracheal colonization factor.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.

Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.

The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.

A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)

An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 4.6.1.1.

One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLYL CYCLASES and hemolysin components.

A polynucleotide formed from the ADP-RIBOSE moiety of nicotinamide-adenine dinucleotide (NAD) by POLY(ADP-RIBOSE) POLYMERASES.

A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)

Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.

The rate dynamics in chemical or physical systems.

A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.

A RHO GTP-BINDING PROTEIN involved in regulating signal transduction pathways that control assembly of focal adhesions and actin stress fibers. This enzyme was formerly listed as EC 3.6.1.47.

Proteins prepared by recombinant DNA technology.

One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.

Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.

Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.

The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.

Established cell cultures that have the potential to propagate indefinitely.

Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

A group of telomere associated proteins that interact with TRF1 PROTEIN, contain ANKYRIN REPEATS and have poly(ADP-ribose) polymerase activity.

A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.

CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.

A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Identification of a new Pyk2 target protein with Arf-GAP activity. (1/1111)

Protein tyrosine kinase Pyk2 is activated by a variety of G-protein-coupled receptors and by extracellular signals that elevate intracellular Ca2+ concentration. We have identified a new Pyk2 binding protein designated Pap. Pap is a multidomain protein composed of an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal SH3 domain. We demonstrate that Pap forms a stable complex with Pyk2 and that activation of Pyk2 leads to tyrosine phosphorylation of Pap in living cells. Immunofluorescence experiments demonstrate that Pap is localized in the Golgi apparatus and at the plasma membrane, where it is colocalized with Pyk2. In addition, in vitro recombinant Pap exhibits strong GTPase-activating protein (GAP) activity towards the small GTPases Arf1 and Arf5 and weak activity towards Arf6. Addition of recombinant Pap protein to Golgi preparations prevented Arf-dependent generation of post-Golgi vesicles in vitro. Moreover, overexpression of Pap in cultured cells reduced the constitutive secretion of a marker protein. We propose that Pap functions as a GAP for Arf and that Pyk2 may be involved in regulation of vesicular transport through its interaction with Pap. (+info)

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. (2/1111)

The ARF6 GTPase regulates a novel endosomal-plasma membrane recycling pathway and influences cortical actin remodeling. Here we examined the relationship between ARF6 and Rac1, a Rho family GTPase, implicated in cortical actin rearrangements. Endogenous Rac1 colocalized with ARF6 at the plasma membrane and on the ARF6 recycling endosome in untransfected HeLa and primary human fibroblast cells. In transfected HeLa cells Rac1 and ARF6 also colocalized. Cells expressing wild-type ARF6 or Rac1 formed actin-containing surface protrusions and membrane ruffles, respectively, upon treatment with the G protein activator aluminum fluoride. Aluminum fluoride-treatment of cells transfected with equivalent amounts of plasmid resulted in enhanced membrane ruffling, with protrusions appearing as Rac expression was lowered. Co-expression of the dominant negative, GTP binding-defective ARF6 T27N mutant inhibited the aluminum fluoride-induced ruffling observed in cells expressing Rac1, and the constitutive ruffling observed in cells expressing the activated Rac1 Q61L mutant. In contrast, co-expression of the GTP-binding-defective, T17N mutant of either Rac1 or Cdc42 with ARF6 did not inhibit the aluminum fluoride-induced surface protrusions, nor did inactivation of Rho with C3-transferase. These observations suggest that ARF6, a non-Rho family GTPase, can, by itself, alter cortical actin and can influence the ability of Rac1 to form lamellipodia, in part, by regulating its trafficking to the plasma membrane. (+info)

Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. (3/1111)

COPI-coated vesicle budding from lipid bilayers whose composition resembles mammalian Golgi membranes requires coatomer, ARF, GTP, and cytoplasmic tails of putative cargo receptors (p24 family proteins) or membrane cargo proteins (containing the KKXX retrieval signal) emanating from the bilayer surface. Liposome-derived COPI-coated vesicles are similar to their native counterparts with respect to diameter, buoyant density, morphology, and the requirement for an elevated temperature for budding. These results suggest that a bivalent interaction of coatomer with membrane-bound ARF[GTP] and with the cytoplasmic tails of cargo or putative cargo receptors is the molecular basis of COPI coat assembly and provide a simple mechanism to couple uptake of cargo to transport vesicle formation. (+info)

GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro. (4/1111)

Recent cloning of a rat brain phosphatidylinositol 3,4, 5-trisphosphate binding protein, centaurin alpha, identified a novel gene family based on homology to an amino-terminal zinc-binding domain. In Saccharomyces cerevisiae, the protein with the highest homology to centaurin alpha is Gcs1p, the product of the GCS1 gene. GCS1 was originally identified as a gene conditionally required for the reentry of cells into the cell cycle after stationary phase growth. Gcs1p was previously characterized as a guanosine triphosphatase-activating protein for the small guanosine triphosphatase Arf1, and gcs1 mutants displayed vesicle-trafficking defects. Here, we have shown that similar to centaurin alpha, recombinant Gcs1p bound phosphoinositide-based affinity resins with high affinity and specificity. A novel GCS1 disruption strain (gcs1Delta) exhibited morphological defects, as well as mislocalization of cortical actin patches. gcs1Delta was hypersensitive to the actin monomer-sequestering drug, latrunculin-B. Synthetic lethality was observed between null alleles of GCS1 and SLA2, the gene encoding a protein involved in stabilization of the actin cytoskeleton. In addition, synthetic growth defects were observed between null alleles of GCS1 and SAC6, the gene encoding the yeast fimbrin homologue. Recombinant Gcs1p bound to actin filaments, stimulated actin polymerization, and inhibited actin depolymerization in vitro. These data provide in vivo and in vitro evidence that Gcs1p interacts directly with the actin cytoskeleton in S. cerevisiae. (+info)

EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization. (5/1111)

We have identified a human cDNA encoding a novel protein, exchange factor for ARF6 (EFA6), which contains Sec7 and pleckstrin homology domains. EFA6 promotes efficient guanine nucleotide exchange on ARF6 and is distinct from the ARNO family of ARF1 exchange factors. The protein localizes to a dense matrix on the cytoplasmic face of plasma membrane invaginations, induced on its expression. We show that EFA6 regulates endosomal membrane recycling and promotes the redistribution of transferrin receptors to the cell surface. Furthermore, expression of EFA6 induces actin-based membrane ruffles that are inhibited by co-expression of dominant-inhibitory mutant forms of ARF6 or Rac1. Our results demonstrate that by catalyzing nucleotide exchange on ARF6 at the plasma membrane and by regulating Rac1 activation, EFA6 coordinates endocytosis with cytoskeletal rearrangements. (+info)

Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors. (6/1111)

Protein secretion through the endoplasmic reticulum and Golgi vesicular trafficking system is initiated by the binding of ADP-ribosylation factors (ARFs) to donor membranes, leading to recruitment of coatomer, bud formation, and eventual vesicle release. ARFs are approximately 20-kDa GTPases that are active with bound GTP and inactive with GDP bound. Conversion of ARF-GDP to ARF-GTP is regulated by guanine nucleotide-exchange proteins. All known ARF guanine nucleotide-exchange proteins contain a Sec7 domain of approximately 200 amino acids that includes the active site and fall into two classes that differ in molecular size and susceptibility to inhibition by the fungal metabolite brefeldin A (BFA). To determine the structural basis of BFA sensitivity, chimeric molecules were constructed by using sequences from the Sec7 domains of BFA-sensitive yeast Sec7 protein (ySec7d) and the insensitive human cytohesin-1 (C-1Sec7). Based on BFA inhibition of the activities of these molecules with recombinant yeast ARF2 as substrate, the Asp965-Met975 sequence in ySec7d was shown to be responsible for BFA sensitivity. A C-1Sec7 mutant in which Ser199, Asn204, and Pro209 were replaced with the corresponding ySec7d amino acids, Asp965, Gln970, and Met975, exhibited BFA sensitivity similar to that of recombinant ySec7d (rySec7d). Single replacement in C-1Sec7 of Ser199 or Pro209 resulted in partial inhibition by BFA, whereas replacement of Gln970 in ySec7d with Asn (as found in C-1Sec7) had no effect. As predicted, the double C-1Sec7 mutant with S199D and P209M was BFA-sensitive, demonstrating that Asp965 and Met975 in ySec7d are major molecular determinants of BFA sensitivity. (+info)

Characterization of the regulation of phospholipase D activity in the detergent-insoluble fraction of HL60 cells by protein kinase C and small G-proteins. (7/1111)

Phospholipase D (PLD) activity has been shown to be GTP-dependent both in vivo and in vitro. One protein that confers GTP sensitivity to PLD activity in vitro is the low-molecular-mass G-protein ADP-ribosylation factor (Arf). However, members of the Rho family and protein kinase C (PKC) have also been reported to activate PLD in various cell systems. We have characterized the stimulation of PLD in HL60 cell membranes by these proteins. The results demonstrate that a considerable proportion of HL60 PLD activity is located in a detergent-insoluble fraction of the cell membrane that is unlikely to be a caveolae-like domain, but is probably cytoskeletal. This PLD activity required the presence of Arf1, a Rho-family member and PKC for efficient catalysis of the lipid substrate, suggesting that the activity represents PLD1. We show that recombinant human PLD1b is regulated in a similar manner to HL60-membrane PLD, and that PKCalpha and PKCdelta are equally effective PLD activators. Therefore maximum PLD activity requires Arf, a Rho-family member and PKC, emphasizing the high degree of regulation of this enzyme. (+info)

The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D. (8/1111)

ADP-ribosylation factor-related protein (ARP) is a membrane-associated GTPase with remote similarity to the family of ADP-ribosylation factors (ARF). In a yeast two-hybrid screen designed to identify proteins interacting with ARP, we isolated a partial cDNA of the ARF-specific guanine nucleotide exchange factor mSec7-1/cytohesin encoding its N terminus and most of the Sec7 domain (codons 1-200). ARP and ARP-Q79L (GTPase-negative ARP) exhibited a higher affinity to mSec7-1-(1-200) than ARP-T31N (nucleotide exchange-defective ARP) in the two-hybrid assay. Similarly, full-length [35S]mSec7-1/cytohesin was specifically adsorbed to glutathione-Sepharose loaded with glutathione S-transferase (GST)-ARP-Q79L, GST-ARP, or GST-ARP-T31N, the latter exhibiting the lowest binding affinity. Overexpression of ARP-Q79L, but not of ARP-T31N, in COS-7 cells reduced the fluorescence from co-expressed green fluorescent protein fused with mSec7-1/cytohesin or mSec7-2/ARNO in plasma membranes as detected by deconvolution microscopy. Recombinant ARP and ARP-Q79L, but not ARP-T31N, inhibited the phospholipase D (PLD) activity stimulated by mSec7-2/ARNO and ARF in a system of isolated membranes. Furthermore, transfection of HEK-293 cells with ARP or ARP-Q79L, but not ARP-T31N, inhibited the muscarinic acetylcholine receptor-3 induced PLD stimulation and translocation of ARF from cytosol to membranes. These data suggest that the GTP-bound form of ARP specifically binds mSec7-1/cytohesin, and that ARP may be involved in a pathway inhibiting the ARF-controlled activity of PLD. (+info)

ADP ribosylation factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family ... The small ADP ribosylation factor (Arf) GTP-binding proteins are major regulators of vesicle biogenesis in intracellular ... Kahn RA, Kern FG, Clark J, Gelmann EP, Rulka C (1991). "Human ADP-ribosylation factors. A functionally conserved family of GTP- ... Amor JC, Harrison DH, Kahn RA, Ringe D (1994). "Structure of the human ADP-ribosylation factor 1 complexed with GDP". Nature. ...

https://en.wikipedia.org/wiki/ADP_ribosylation_factor

ADP-ribosylation factor regulates hPLD2". The Journal of Biological Chemistry. 273 (21): 12846-52. doi:10.1074/jbc.273.21.12846 ... "Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor- ... "Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor- ... May 2003). "The direct interaction of phospholipase C-gamma 1 with phospholipase D2 is important for epidermal growth factor ...

https://en.wikipedia.org/wiki/PLD2

ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene. ADP-ribosylation factor 1 (ARF1) is a member ... Frank S, Upender S, Hansen SH, Casanova JE (1998). "ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6 ... ARF1 ADP-ribosylation factor 1". Mitchell R, Robertson DN, Holland PJ, Collins D, Lutz EM, Johnson MS (September 2003). "ADP- ... 1991). "ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding ...

https://en.wikipedia.org/wiki/ARF1

December 1995). "Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly ... July 1998). "Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA". FEBS Letters. 430 ( ... July 1998). "Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA". FEBS Letters. 430 ( ... Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric ...

https://en.wikipedia.org/wiki/Phospholipase_D1

ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety ... Frank S, Upender S, Hansen SH, Casanova JE (1998). "ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6 ... "ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1". J. Biol. Chem. 274 (38): 27099-104. doi: ... "Entrez Gene: ARF6 ADP-ribosylation factor 6". Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ (November ...

https://en.wikipedia.org/wiki/ARF6

ADP-ribosylation factor-like protein 13B (ARL13B), also known as ADP-ribosylation factor-like protein 2-like 1, is a protein ... "Entrez Gene: ADP-ribosylation factor-like 13B". Cantagrel V, Silhavy JL, Bielas SL, Swistun D, Marsh SE, Bertrand JY, Audollent ... This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both ...

https://en.wikipedia.org/wiki/ARL13B

ADP-ribosylation factor 5 is a protein that in humans is encoded by the ARF5 gene. ADP-ribosylation factor 5 (ARF5) is a member ... "Entrez Gene: ARF5 ADP-ribosylation factor 5". Kanoh, H; Williger B T; Exton J H (February 1997). "Arfaptin 1, a putative ... Shin OH, Couvillon AD, Exton JH (2001). "Arfophilin is a common target of both class II and class III ADP-ribosylation factors ... Shin, O H; Exton J H (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. ...

https://en.wikipedia.org/wiki/ARF5

ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene. ADP-ribosylation factor 4 (ARF4) is a member ... ARF4 ADP-ribosylation factor 4". Kim SW, Hayashi M, Lo JF, Yang Y, Yoo JS, Lee JD (Jan 2003). "ADP-ribosylation factor 4 small ... "ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation". J. ... Kahn RA, Kern FG, Clark J, Gelmann EP, Rulka C (1991). "Human ADP-ribosylation factors. A functionally conserved family of GTP- ...

https://en.wikipedia.org/wiki/ARF4

ADP-ribosylation factor-like 15 is a protein in humans that is encoded by the ARL15 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ADP-ribosylation factor-like 15". Retrieved 2013-03-16. v t e (Articles with short description, Short description ...

https://en.wikipedia.org/wiki/ARL15

ADP-ribosylation factor 3 is a protein that in humans is encoded by the ARF3 gene. ADP-ribosylation factor 3 (ARF3) is a member ... "Entrez Gene: ARF3 ADP-ribosylation factor 3". Kanoh H, Williger BT, Exton JH (February 1997). "Arfaptin 1, a putative cytosolic ... Williger BT, Provost JJ, Ho WT, Milstine J, Exton JH (July 1999). "Arfaptin 1 forms a complex with ADP-ribosylation factor and ... Lee CM, Haun RS, Tsai SC, Moss J, Vaughan M (1992). "Characterization of the human gene encoding ADP-ribosylation factor 1, a ...

https://en.wikipedia.org/wiki/ARF3

ADP-ribosylation factor-like protein 8A is a protein that in humans is encoded by the ARL8A gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ARL8A ADP-ribosylation factor-like 8A". Human ARL8A genome location and ARL8A gene details page in the UCSC Genome ...

https://en.wikipedia.org/wiki/ARL8A

ADP-ribosylation factor-like protein 8B is a protein that in humans is encoded by the ARL8B gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ARL8B ADP-ribosylation factor-like 8B". Human ARL8B genome location and ARL8B gene details page in the UCSC Genome ...

https://en.wikipedia.org/wiki/ARL8B

ADP-ribosylation factor-like protein 4D is a protein that in humans is encoded by the ARL4D gene. ADP-ribosylation factor 4D is ... "Entrez Gene: ARL4D ADP-ribosylation factor-like 4D". "DEXA data for Arl4d". Wellcome Trust Sanger Institute. "Radiography data ... Jacobs S, Schilf C, Fliegert F, Koling S, Weber Y, Schürmann A, Joost HG (Aug 1999). "ADP-ribosylation factor (ARF)-like 4, 6, ... "Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients ...

https://en.wikipedia.org/wiki/ARL4D

ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, ... ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene. The protein encoded by this ... "Entrez Gene: ARL1 ADP-ribosylation factor-like 1". Lu L, Hong W (September 2003). "Interaction of Arl1-GTP with GRIP domains ... Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA (June 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have ...

https://en.wikipedia.org/wiki/ARL1

ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene. ADP-ribosylation factor-like 3 ... "Entrez Gene: ARL3 ADP-ribosylation factor-like 3". Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M ... Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA (June 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have ... Kim HS (1998). "Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation ...

https://en.wikipedia.org/wiki/ARL3

ADP-ribosylation factor-like protein 6 is a protein that in humans is encoded by the ARL6 gene. The protein encoded by this ... "Entrez Gene: ARL6 ADP-ribosylation factor-like 6". GeneReviews/NIH/NCBI/UW entry on Bardet-Biedl Syndrome Human ARL6 genome ... 1999). "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid ... 1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS ...

https://en.wikipedia.org/wiki/ARL6

ADP-ribosylation factor-like protein 11 is a protein that in humans is encoded by the ARL11 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ARL11 ADP-ribosylation factor-like 11". Human ARL11 genome location and ARL11 gene details page in the UCSC Genome ...

https://en.wikipedia.org/wiki/ARL11

ADP ribosylation factor like GTPase 13A is a protein that in humans is encoded by the ARL13A gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ADP ribosylation factor like GTPase 13A". Retrieved 2017-02-09. v t e (Articles with short description, Short ...

https://en.wikipedia.org/wiki/ARL13A

ADP-ribosylation factor-like protein 2 is a protein that in humans is encoded by the ARL2 gene. The ADP-ribosylation factor ( ... "Entrez Gene: ARL2 ADP-ribosylation factor-like 2". Hanke-Gogokhia, C.; Zhang, H.; Frederick, J. M.; Baehr, W. (2016). "The ... Beghin A, Honore S, Messana C, Matera EL, Aim J, Burlinchon S, Braguer D, Dumontet C (2007). "ADP ribosylation factor like 2 ( ... Bhamidipati A, Lewis SA, Cowan NJ (May 2000). "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of ...

https://en.wikipedia.org/wiki/ARL2

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene. The protein encoded by ... "Entrez Gene: ARFRP1 ADP-ribosylation factor related protein 1". Schürmann A, Schmidt M, Asmus M, Bayer S, Fliegert F, Koling S ... It is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. The gene is located in a gene cluster that ... 1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide ...

https://en.wikipedia.org/wiki/ARFRP1

ADP ribosylation factor like GTPase 6 interacting protein 6 is a protein that in the humans is encoded by the ARL6IP6 gene. It ... "ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov ... "ADP ribosylation factor like GTPase 6 interacting protein 6". NCBI Gene. "UniProtKB - Q8N6S5 (AR6P6_HUMAN)". uniprot.org. ...

https://en.wikipedia.org/wiki/ARL6IP6

"ARL14 ADP-ribosylation factor-like 14 [Homo sapiens (human)". Entrez Gene. "ARL14EP ADP-ribosylation factor-like 14 effector ... PSD4 as a guanine exchange factor, loads ARL14/ARF7 with GTP. Subsequently, ARF7EP interacts with MYO1E which binds itself to ... PSD4 (Pleckstrin and Sec7 Domain containing 4) is a GEF (Guanine nucleotide Exchange Factor) that loads ARL14/ARF7 with GTP. ... is due to mutations in the genes that code for transcription factors that regulate the expression of the MHC class II genes. It ...

https://en.wikipedia.org/wiki/MHC_class_II

Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ (July 2000). "The GIT family of ADP-ribosylation factor GTPase- ... a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proc. Natl. Acad. Sci. U.S.A ... receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor". J. ...

https://en.wikipedia.org/wiki/G_protein-coupled_receptor_kinase_2

Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ (Jul 2000). "The GIT family of ADP-ribosylation factor GTPase-activating ... GIT proteins interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating ... "An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin ... a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proceedings of the National ...

https://en.wikipedia.org/wiki/GIT2

BFA blocks the activation of some ADP-ribosylation factors (ARFs). ARFs are small GTPases which regulate vesicular trafficking ... BFA inhibits the function of several guanine nucleotide exchange factors (GEFs) that mediate GTP-binding of ARFs. Treatment of ...

https://en.wikipedia.org/wiki/Golgi_apparatus

ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene. The protein ... "Entrez Gene: ARFGAP3 ADP-ribosylation factor GTPase activating protein 3". Human ARFGAP1 genome location and ARFGAP1 gene ... which associates with the Golgi apparatus and which is thought to interact with ADP-ribosylation factor 1 (ARF1). The encoded ...

https://en.wikipedia.org/wiki/ARFGAP3

Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ (2000). "The GIT family of ADP-ribosylation factor GTPase-activating ... Shin EY, Woo KN, Lee CS, Koo SH, Kim YG, Kim WJ, Bae CD, Chang SI, Kim EG (2004). "Basic fibroblast growth factor stimulates ... Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene. ARHGEF7 is commonly known ... βPIX contains a central DH/PH RhoGEF domain that functions as a guanine nucleotide exchange factor (GEF) for small GTPases of ...

https://en.wikipedia.org/wiki/ARHGEF7

Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ (August 2000). "The GIT family of ADP-ribosylation factor GTPase- ... a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proc Natl Acad Sci U S A. 95 ... Zhao ZS, Manser E, Loo TH, Lim L (September 2000). "Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal ... Zhao ZS, Manser E, Loo TH, Lim L (2000). "Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex ...

https://en.wikipedia.org/wiki/GIT1

"Entrez Gene: ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5". Human ARL6IP5 genome location and ARL6IP5 gene ... 1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS ...

https://en.wikipedia.org/wiki/ARL6IP5

"Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)". D'Souza-Schorey C, Boshans RL, McDonough M, ... Kanoh H, Williger BT, Exton JH (February 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is ... Shin OH, Exton JH (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical ... Shin OH, Exton JH (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical ...

https://en.wikipedia.org/wiki/ARFIP2

In several coronaviruses, ADP-ribosylation of the N protein has also been reported. With unclear functional significance, the ... by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3". ... "The coronavirus nucleocapsid protein is ADP-ribosylated". Virology. 517: 62-68. doi:10.1016/j.virol.2017.11.020. PMC 5871557. ...

https://en.wikipedia.org/wiki/Coronavirus_nucleocapsid_protein

... belongs to an ADP-ribosylation factor GTPase-activating (ARF-GAP) protein family involved in membrane traffic and actin ... phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton". The Journal of ...

https://en.wikipedia.org/wiki/CENTG2

... encoding protein ADP-ribosylation factor-like protein 6-interacting protein 1 ARMC5 BMIQ5: Body mass index quantitative trait ... Chemokine-like factor CLUAP1: CMTM2: encoding protein CKLF-like MARVEL transmembrane domain-containing protein 2 CCDC135: ... encoding protein VPS35 Endosomal Protein Sorting Factor Like WFDC1: encoding protein WAP four-disulfide core domain protein 1 ... encoding protein Polyamine-modulated factor 1-binding protein 1 POLR3K: encoding enzyme DNA-directed RNA polymerase III subunit ...

https://en.wikipedia.org/wiki/Chromosome_16

ADP-ribosylation, deamination and proline isomerization; acetylation, methylation, phosphorylation and ubiquitination have been ... The transposase is used to insert tags in the genome, with higher frequency on regions not covered by proteic factors. The tags ... And, while DNA binding transcription factors provide a mechanism for specific control of cellular responses, a model where DNA ... However instead of isolating a DNA-binding transcription factor or enhancer protein through chromatin immunoprecipitation, the ...

https://en.wikipedia.org/wiki/Epigenomics

In addition, the inactivation of Rho protein by ADP-ribosylation in Rac1 microinjection reduced the formation of actin stress ... Indeed, Rho-dependent response is stimulated by the action of growth factors on Rac protein. In 1993 he moved to University ... The inhibition of Rho by C3 transferase ribosylation resulted in an inhibition of focal adhesion and stress fibre assembly, but ... This led to the conclusion that CNK1 couples specific Rho exchange factors to the JNK MAP kinase pathway, providing specificity ...

https://en.wikipedia.org/wiki/Alan_Hall

Cholera: ADP-ribosylation caused by cholera toxin results in increased production of cyclic AMP which in turn opens the CFTR ... April 1992). "Primary hepatocellular carcinoma with severe hypoglycemia: involvement of insulin-like growth factors". Liver. 12 ... and RACK1 binding to Na+/H+ exchange regulatory factor". The Journal of Biological Chemistry. 277 (25): 22925-22933. doi: ... receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor ...

https://en.wikipedia.org/wiki/Cystic_fibrosis_transmembrane_conductance_regulator

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction ... Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as ... This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA ... Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene. ...

https://en.wikipedia.org/wiki/PARP4

Zhao L, Helms JB, Brunner J, Wieland FT (1999). "GTP-dependent binding of ADP-ribosylation factor to coatomer in close ... 1997). "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor". Biochem. Biophys. Res. ...

https://en.wikipedia.org/wiki/COPB1

1998). "Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange ... 1998). "ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of ... and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ... guanine nucleotide-exchange proteins for ADP-ribosylation factors". J. Biol. Chem. 275 (5): 3221-30. doi:10.1074/jbc.275.5.3221 ...

https://en.wikipedia.org/wiki/CYTH3

... and the A1 subunit is freed to bind with a human partner protein called ADP-ribosylation factor 6 (Arf6). Binding exposes its ... The A1 portion of the A subunit is an enzyme that ADP-ribosylates G proteins, while the A2 chain fits into the central pore of ... Risk factors for the disease include poor sanitation, not enough clean drinking water, and poverty. Cholera can be diagnosed by ... "Sources of Infection & Risk Factors". Centers for Disease Control and Prevention. November 7, 2014. Archived from the original ...

https://en.wikipedia.org/wiki/Cholera

Vibrio cholerae produces a similar protein called the Cholix toxin (Q5EK40). It inhibits elongation factor-2. It does so by ADP ... ribosylation of EF2 using NAD+. This then causes the elongation of polypeptides to cease. This mechanism is similar to that of ... a novel ADP-ribosylating factor from Vibrio cholerae". The Journal of Biological Chemistry. 283 (16): 10671-8. doi:10.1074/jbc. ... Yates SP, Merrill AR (May 2004). "Elucidation of eukaryotic elongation factor-2 contact sites within the catalytic domain of ...

https://en.wikipedia.org/wiki/Pseudomonas_exotoxin

ADP-ribosylation factor GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARFGAP1 gene. Two transcript ... which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein ...

https://en.wikipedia.org/wiki/ARFGAP1

P. aeruginosa uses the virulence factor exotoxin A to inactivate eukaryotic elongation factor 2 via ADP-ribosylation in the ... An important factor found to be associated with antibiotic resistance is the decrease in the virulence capabilities of the ... Pyocyanin is a virulence factor of the bacteria and has been known to cause death in C. elegans by oxidative stress. However, ... Without elongation factor 2, eukaryotic cells cannot synthesize proteins and necrotise. The release of intracellular contents ...

https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa

Toxin B (cytotoxin) induces actin depolymerization by a mechanism correlated with a decrease in the ADP-ribosylation of the low ... Additional virulence factors include an adhesion factor that mediates the binding to human colonic cells and a hyaluronidase. ... GI disturbances in carriers appear to trigger periods of increased shedding which may be an important factor for transmission.[ ... Antibiotic treatment of C. diff infections may be difficult, due both to antibiotic resistance and physiological factors of the ...

https://en.wikipedia.org/wiki/Clostridioides_difficile

This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its ... Vitale N, Horiba K, Ferrans VJ, Moss J, Vaughan M (Jul 1998). "Localization of ADP-ribosylation factor domain protein 1 (ARD1) ... Vitale N, Moss J, Vaughan M (Oct 1997). "Characterization of a GDP dissociation inhibitory region of ADP-ribosylation factor ... Vitale N, Moss J, Vaughan M (Jan 1998). "Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor ...

https://en.wikipedia.org/wiki/TRIM23

"Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs)". EMBO J. 20 (22 ...

https://en.wikipedia.org/wiki/AP4M1

... a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proceedings of the National ...

https://en.wikipedia.org/wiki/GRK5

The life span of 13 mammalian species correlated with poly(ADP ribosyl)ation capability measured in mononuclear cells. ... An increase in cellular apoptosis may correlate to aging, but is not a 'cause of death'. Environmental factors and genetic ... ADP-ribosyl)ation capability than control cell lines from younger individuals. The cross-linking theory proposes that advanced ... Further support for the theory that DNA damage is the primary cause of aging comes from study of Poly ADP ribose polymerases ( ...

https://en.wikipedia.org/wiki/Biogerontology

ADP-ribosylation, and ubiquitination have also been reported. These combinations of different covalent modifications on the N- ... and the general transcription factors TFIIE and TFIIF. Other substrates include the transcription factors Sp1, KLF5, FOXO1, ... MORF (MOZ-related factor) exhibits very close homology to MOZ throughout its entire length. It contains an N-terminal ... TAFII250 is one of the TBP-associated factor subunits of TFIID, and it shares a Gly-X-Gly pattern with Gcn5 that is important ...

https://en.wikipedia.org/wiki/Histone_acetyltransferase

... encoding protein ADP-ribosylation factor GTPase-activating protein 3 ASCC2: encoding protein Activating signal cointegrator 1 ... encoding protein Thyrotroph embryonic factor THAP7: encoding protein THAP domain-containing protein 7 THOC5: encoding protein ... complex subunit 2 ATF4 (22q13) encoding protein cyclic AMP-dependent transcription factor ATF-4 BCR (22q11) encoding breakpoint ...

https://en.wikipedia.org/wiki/Chromosome_22

... of arfaptin 1 on guanine nucleotide-dependent activation of phospholipase D and cholera toxin by ADP-ribosylation factor". J. ... 2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream ... 2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochim. ...

https://en.wikipedia.org/wiki/MTG1

... to arginine or other guanidine compounds by utilizing ADP-ribosylation factors (ARFs). In the absence of arginine or simple ... Locht, C; Antoine, R (1995). "A proposed mechanism of ADP-ribosylation catalyzed by the pertussis toxin S1 subunit". Biochimie ... the A1 domain unfolds and is redirected back to the cytosol where it refolds and catalyzes ADP-ribosylation of certain G ... This is accomplished through fusion of epidermal growth factor (EGF) with SubAB's A subunit. Cancer cells that express ...

https://en.wikipedia.org/wiki/AB5_toxin

ADP-ribosylation toxin is one of the effector molecules secreted by several pathogenic bacteria and translocated through the ... T3SS is a specialized protein secretion machinery that exports virulence factors directly to host cells. These factors subvert ...

https://en.wikipedia.org/wiki/Aeromonas_hydrophila

ADP-ribosylation factor like GTPase 10 Arl10 ADP-ribosylation factor-like 10 Nomenclature updated to reflect human and mouse ... ADP-ribosylation factor-like 10 Symbol and Name status set to approved. 1299863. APPROVED. ... ARL10 (ADP ribosylation factor like GTPase 10) Alliance. DIOPT (Ensembl Compara,HGNC,Hieranoid,InParanoid,OMA,OrthoFinder, ... ARL10 (ADP ribosylation factor like GTPase 10). HGNC. Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther. ...

https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1303298

Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish ... ADP-Ribosylation Factors, Animals, Animals, Genetically Modified, Cardiovascular System, Embryo, Nonmammalian, Gene Expression ... In situ localization of highly elevated transcripts revealed intense staining of ADP-ribosylation factors arf3 and arf5 in the ... Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish ...

https://fwcs.oregonstate.edu/biblio/early-life-stage-trimethyltin-exposure-induces-adp-ribosylation-factor-expression-and-0

... and that this is through the regulation of secretion of fibroblast growth factor-2, a guidance factor for migration of ... show in vivothat Arf6 positively regulates oligiodendrocyte myelination via the release of the growth factor FGF-2 from ... The small G protein ADP-ribosylation factor 6 (Arf6) plays important roles in a wide variety of membrane dynamics-based ... Mammalian ADP-ribosylation factor (Arf) is a small GTPase cycling between an inactive GDP-bound and active GTP-bound form. Arf ...

https://www.nature.com/articles/ncomms5744?error=cookies_not_supported&code=eb053ac1-2b23-4e94-b201-4cd1407f04fd

ARFGEF2: ADP ribosylation factor guanine nucleotide exchange factor 2. *ARG1: arginase 1 ...

https://medlineplus.gov/genetics/gene

13] ; ADP-ribosylation factor plays a significant role in the growth of Mucorales. [13] Neutrophils are the key host defense ... Risk factors. Immunocompromising conditions are the main risk factors for mucormycosis. Patients with uncontrolled diabetes ... Risk factors such as diabetic ketoacidosis and neutropenia are present in most cases. Severe sinusitis, complicated by brain ... Demographic and Socioeconomic Factors Associated With Fungal Infection Risk, United States, 2019 1.0 CME / ABIM MOC Credits ...

https://www.medscape.com/answers/222551-121800/what-is-the-prognosis-of-mucormycosis-zygomycosis

PEPTIDE ELONGATION FACTOR 1 FACTOR 1 DE ELONGACION PEPTIDA FATOR 1 DE RIBOSILAÇÃO DO ADP ADP-RIBOSYLATION FACTOR 1 FACTOR 1 DE ... FATORES DE RIBOSILAÇÃO DO ADP ADP-RIBOSYLATION FACTORS FACTORES DE RIBOSILACION-ADP ... GLIA MATURATION FACTOR FACTOR DE MADURACION DE LA GLIA FATOR G PARA ELONGAÇÃO DE PEPTÍDIOS PEPTIDE ELONGATION FACTOR G FACTOR G ... GUANINE NUCLEOTIDE-RELEASING FACTOR 2 FACTOR 2 LIBERADOR DE GUANINA NUCLEOTIDO FATOR DE CRESCIMENTO NEURAL NERVE GROWTH FACTOR ...

https://decs.bvs.br/P/news2000pie.htm

Structure of human ADP-ribosylation factor-like 5 (ARL5). 2h17. Structure of human ADP-ribosylation factor-like 5 (ARL5) (CASP ... ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae. 1mr3. Saccharomyces cerevisiae ADP-ribosylation Factor 2 ( ... Delta-17 Human ADP Ribosylation Factor 1 Complexed with GDP. 1upt. Structure of a complex of the golgin-245 GRIP domain with ... Crystal Structure of Plasmodium falciparum ADP-Ribosylation Factor 1. 3lvq. The crystal structure of ASAP3 in complex with Arf6 ...

https://smart.embl.de/smart/do_annotation.pl?DOMAIN=ARF&START=1&END=175&E_VALUE=2.34e-134&TYPE=SMART&BLAST=MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS

Centaurin beta2/KIAA0041, is a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins. ... COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport ... COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport ... COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport ...

https://www.ncbi.nlm.nih.gov/gene/23527

ADP-ribosylation factor 1. MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIG.... unknown. Bifunctional 3-phosphoadenosine 5- ...

https://www.rcsb.org/ligand/GOL

ADP-ribosylation factor-like 14. MGI:1918869 Go Annotations as Summary Text (Tabular View) (GO Graph). Automated description ... Orthologous to human ARL14 (ADP ribosylation factor like GTPase 14).. Go Annotations in Tabular Form (Text View) (GO Graph) ...

http://www.informatics.jax.org/go/marker/MGI:1918869

ARFGEF1 ADP ribosylation factor guanine nucleotide exchange factor 1. GPX3 glutathione peroxidase 3 ... 2021). Loss of Nucleoporin Nup50 is a Risk Factor for Amyotrophic Lateral Sclerosis. medRxiv. doi:10.1101/2021.08.23.21262299 ( ... Insulin-like Growth Factors and Clinical Features. Eur. J. Neurol. 17 (5), 666-671. doi:10.1111/j.1468-1331.2009.02896.x ... A loss of inhibitory neuron influence is an important factor leading to ALS pathogenesis (Turner and Kiernan, 2012). ...

https://www.frontiersin.org/articles/10.3389/fgene.2022.917142/full

After the mAb binds to CD22, the molecule is internalized; internalization results in ADP-ribosylation of elongation factor 2, ... Recombinant Granulocyte Colony-Stimulating Factors (G-CSFs). Class Summary. Because treatment of hairy cell leukemia is ... Also, the availability of recombinant human hematopoietic growth factors has improved supportive care during life-threatening ...

https://emedicine.medscape.com/article/200580-medication

ADP-ribosylation factor. - Molecular Function: GTP binding (GO:0005525). - Cellular Component: intracellular (GO:0005622). - ... ADP-ribosylation factor 3 OS=Arabidopsis thaliana GN=ARF3 PE=1 SV=2. ... Symbols: ARF3, ARL1, ATARL1 , ARF3/ARL1/ATARL1 (ADP-RIBOSYLATION FACTOR 3); protein binding , …. ...

https://www.sgn.cornell.edu/search/unigene.pl?unigene_id=SGN-U272342

ADP-Ribosylation Factor. Saccharomyces cerevisiae. Necessary For Fitness 50% ARF1. 853374. ARG2. ARGinine requiring. ... Elongation Factor Two. Saccharomyces cerevisiae. Necessary For Fitness 30% EFT1. 851993. EFT2. Elongation Factor Two. ... ADP/ATP Carrier. Saccharomyces cerevisiae. Anti-Longevity 15% AAC3. 855581. AAH1. Adenine AminoHydrolase. Saccharomyces ... potential anaphase-promoting complex processivity factor Apc10. Saccharomyces cerevisiae. Pro-Longevity APC10. ...

https://genomics.senescence.info/genes/search.php?organism=Saccharomyces+cerevisiae&show=4

Name: ADP-ribosylation factor 2. Type: Gene. Species: Mus musculus (mouse). Chromosome: 11 ...

https://www.mmrrc.org/catalog/sds.php?mmrrc_id=42031

Ras GTPase; ADP ribosylation factor; ARF/SAR superfamily Small GTPase-mediated signal transduction GTP binding; protein binding ... Ras GTPase; ADP ribosylation factor; ARF/SAR superfamily Small GTPase-mediated signal transduction GTP binding; protein binding ... ATR suppression in turn leads to the increased expression of Sox10, which can in turn regulate MITF, a transcription factor ... Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin ...

https://aacrjournals.org/cancerres/article/72/21/5516/575978/RhoJ-Regulates-Melanoma-Chemoresistance-by?searchresult=1

ADP-ribosylation factor [52614] (14 species). *. Species Bakers yeast (Saccharomyces cerevisiae), ARF2 [TaxId:4932] [82401] (1 ... Elongation factor G (EF-G), N-terminal (G) domain [52633] (2 species). has internal nucleotide exchange factor built in as an ... Elongation factor eEF-1alpha, N-terminal (G) domain [52631] (2 species). eukaryotic and archaeal homologue of EF-Tu. ... Initiation factor eIF2 gamma subunit, N-terminal (G) domain [75204] (3 species). includes rubredoxin-like zinc finger insert ...

http://scop.berkeley.edu/sunid=52592&ver=1.75

ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1. Langille SE, Patki V, Klarlund JK, Buxton JM ...

https://pubmed.ncbi.nlm.nih.gov/?cmd=search&term=Langille+SE%5Bau%5D&dispmax=50

keywords = "orexin, OX1 receptor, PLD, PKC, PKD, Rho, PROTEIN-KINASE-C, ADP-RIBOSYLATION FACTOR, RAT ADRENOCORTICAL-CELLS, ...

https://researchportal.helsinki.fi/fi/publications/ox1-orexinhypocretin-receptor-activation-of-phospholipase-d

ADP-ribosylation factor-dependent phospholipase D activation by the M-3 muscarinic receptor. Mitchell, R., Robertson, D. N., ...

https://pureportal.strath.ac.uk/en/publications/?ordering=title&descending=false&showAdvanced=false&allConcepts=true&inferConcepts=true&originalSearch=&improvedLayoutOrganisationUuid=&format=&page=44

Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP. Traffic 8 (5), pp. 582 - 593 ( ...

https://www.biochem.mpg.de/publication-search/6290118?person=%2Fpersons%2Fresource%2Fpersons78772

The large Immunity-related GTPases and the small GTPase ADP-ribosylation factor-6 in host cells are known to accumulate on the ... The large Immunity-related GTPases and the small GTPase ADP-ribosylation factor-6 in host cells are known to accumulate on the ... The large Immunity-related GTPases and the small GTPase ADP-ribosylation factor-6 in host cells are known to accumulate on the ... The large Immunity-related GTPases and the small GTPase ADP-ribosylation factor-6 in host cells are known to accumulate on the ...

https://pennstate.pure.elsevier.com/en/publications/enzymatically-active-rho-and-rac-small-gtpases-are-involved-in-th

In contrast, glutamine activates mTORC1 through a Rag GTPase-independent mechanism that requires ADP-ribosylation factor 1 ( ... Alkaline intracellular pH (pHi) activates AMPK-mTORC2 signaling to promote cell survival during growth factor limitation. ... is critical for inhibiting the nuclear translocation of transcription factor EB (TFEB). ... complex serves as a substrate-specific mTORC1 scaffold in regulating the nuclear translocation of transcription factor EB. ...

https://www.jbc.org/jbc-communications?startPage=&KeywordRaw=mTORC1

ADP-ribosylation factor-like 3. Tssr159654. 19. 46558297 to 46558333 36. -. TSS region. transcription start site region 159654 ...

https://phenome.jax.org/markers/search?searchterm=19%3A46544033-46764041

Role of ADP ribosylation factor 1 in the assembly and secretion of ApoB-100-containing lipoproteins.. Asp L, Magnusson B, ... Complement: a novel factor in basal and ischemia-induced neurogenesis. Rahpeymai Y, Hietala MA, Wilhelmsson U, Fotheringham A, ... McCarthy, A. J., G. M. H. Birchenough and P. W. Taylor (2019). "Loss of Trefoil Factor 2 Sensitizes Rat Pups to Systemic ... Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic ...

https://www.gu.se/en/core-facilities/centre-for-cellular-imaging/publications-from-cci-users-and-staff

ADP ribosylation factor GTPase activating protein 2, ADP-ribosylation factor GTPase activating protein 2, ADP ribosylation ... anti-ADP-Ribosylation Factor GTPase Activating Protein 2 (arfgap2) (AA 242-521) antibody arfgap2 Reactivity: Human IF, WB Host ... anti-ADP-Ribosylation Factor GTPase Activating Protein 2 (arfgap2) (AA 1-521) antibody arfgap2 Reactivity: Human WB Host: ... anti-ADP-Ribosylation Factor GTPase Activating Protein 2 (arfgap2) (AA 331-431) antibody arfgap2 Reactivity: Human ELISA, WB ...

https://www.antibodies-online.com/antibody/529675/anti-ADP-Ribosylation+Factor+GTPase+Activating+Protein+2+arfgap2+AA+1-521+antibody/

PEA is a virulence factor with enzymatic activity leading to ADP-ribosylation of the eukaryotic elongation factor 2 (eEF-2) on ... This can be attributed to the enzymatic activity of our immunotoxin, which allows one molecule of immunotoxin to ADP-ribosylate ... of bfl-1/a1 and its processing in response to tnf receptor activation in fl5.12 pro-b cells convert it into a prodeath factor. ...

https://www.mdpi.com/2072-6694/12/6/1648

Genetic analysis of ADP-Ribosylation Factor 1 (ARF1) in yeast Click, E. S., Stearns, T., Botstein, D. AMER SOC CELL BIOLOGY. ... ADP-RIBOSYLATION FACTOR IS FUNCTIONALLY AND PHYSICALLY ASSOCIATED WITH GOLGI-COMPLEX PROCEEDINGS OF THE NATIONAL ACADEMY OF ... ADP RIBOSYLATION FACTOR IS AN ESSENTIAL PROTEIN IN SACCHAROMYCES-CEREVISIAE AND IS ENCODED BY 2 GENES MOLECULAR AND CELLULAR ... Members of the ADP-ribosylation factor (Arf) family of small GTPases are implicated in vesicle traffic in the secretory pathway ...

https://profiles.stanford.edu/tim-stearns

1998) Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. J Biol ... phospholipase D2 localizes to the plasma membrane of RBL-2H3 mast cells and can be distinguished from ADP ribosylation factor- ... GVII , platelet-activating factor acetylhydrolase , PAF acetylhydrolase , LDL-associated phospholipase A2 , LDL-PLA2 , PAFAH , ... ENTPD1 sequentially converts extracellular purine nucleotides (ATP and ADP) to the monophosphate form. Adenosine is then ...

https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=799

Mammalian ADP-ribosylation factor (Arf) is a small GTPase cycling between an inactive GDP-bound and active GTP-bound form. (nature.com)
These processes of guanine nucleotide exchange and GTP hydrolysis are regulated and accelerated by guanine nucleotide exchange factors and GTPase-activating proteins, respectively. (nature.com)
The large Immunity-related GTPases and the small GTPase ADP-ribosylation factor-6 in host cells are known to accumulate on the parasitophorous vacuole membrane (PVM) of Toxoplasma gondii and play critical roles in this parasite infection, but these GTPases cannot explain the full extent of infection. (elsevier.com)
In contrast, glutamine activates mTORC1 through a Rag GTPase-independent mechanism that requires ADP-ribosylation factor 1 (Arf1). (jbc.org)

The small G protein ADP-ribosylation factor 6 (Arf6) plays important roles in a wide variety of membrane dynamics-based cellular events such as neurite outgrowth and spine formation in vitro . (nature.com)
internalization results in ADP-ribosylation of elongation factor 2, inhibition of protein synthesis, and apoptotic cell death. (medscape.com)
Here, we demonstrate that Ragulator, a heteropentameric protein complex required for mTORC1 activation in response to amino acids, is critical for inhibiting the nuclear translocation of transcription factor EB (TFEB). (jbc.org)
Inhibition of the Adp-Glucose Pyrophosphorylase in Transgenic Potatoes Leads to Sugar-Storing Tubers and Influences Tuber Formation and Expression of Tuber Storage Protein Genes. (mpg.de)
In vitro, basal PLD1 activity is usually low and can be stimulated by a variety of factors, including phosphatidylinositol 4, 5-bisphosphate (PIP 2 ), protein kinase C (PKC), and several small GTPases, e.g. (biomedcentral.com)
Computational insight into the three-dimensional structure of ADP ribosylation factor like protein 15, a novel susceptibility gene for rheumatoid arthritis. (cdc.gov)
SPG61 is due to a mutation in the ARL6IP1 gene (16p12-p11.2) encoding the ADP-ribosylation factor-like protein 6-interacting protein 1. (cdc.gov)

ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1. (nih.gov)
This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. (creativebiomart.net)

Fecal luminal factors from patients with irritable bowel syndrome induce distinct gene expression of colonoids. (gu.se)
These include the vertebrate Hh receptor Patched1 (Ptch1), the obligate transducer of the pathway Smoothened (Smo), as well as the Gli transcription factors (Ci in Drosophila ) that act as both activators (GliA) and repressors (GliR) to control target gene transcription ( Briscoe and Thérond, 2013 ). (elifesciences.org)

ADP ribosylation factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical components of vesicular trafficking pathways in eukaryotes. (embl.de)
MONOMERIC GTP-BINDING PROTEINS that were initially recognized as allosteric activators of the MONO(ADP-RIBOSE) TRANSFERASE of the CHOLERA TOXIN catalytic subunit. (bvsalud.org)

In situ localization of highly elevated transcripts revealed intense staining of ADP-ribosylation factors arf3 and arf5 in the head, trunk, and tail regions. (oregonstate.edu)

Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP. (mpg.de)

Other high-risk groups include patients with cancer, especially those who are neutropenic and those receiving broad-spectrum antibiotics, and individuals receiving immunosuppressive agents, including oral or intravenous steroids and tumor necrosis factor (TNF)-alpha blockers (patients with rheumatoid disorders). (medscape.com)

The recruited CFP-RhoA on the PVM could not be activated by epithelial growth factor (EGF) and no translocation was observed, unlike the unassociated RhoA in the host cell cytosol that migrated to the cell membrane towards the EGF activation spot. (elsevier.com)

Isolation and Expression Analysis of Cdna Clones Encoding a Small and a Large Subunit of Adp-Glucose Pyrophosphorylase from Sugar-Beet. (mpg.de)

E2F transcription factor 4. (gsea-msigdb.org)

One of 2 Different Adp-Glucose Pyrophosphorylase Genes from Potato Responds Strongly to Elevated Levels of Sucrose. (mpg.de)

Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish. (oregonstate.edu)

nuclear factor of activate. (gsea-msigdb.org)
nuclear factor, interleuki. (gsea-msigdb.org)

The virulence factor involved in the pathogenesis of Mucorales is high affinity iron permease (FTR1), allowing Mucorales survival in iron-poor environments. (medscape.com)

Here we generate conditional knockout mice lacking Arf6 in neurons, oligodendrocytes, or both cell lineages, and unexpectedly find that Arf6 expression in neurons, but not in oligodendrocytes, is crucial for oligodendrocyte myelination in the hippocampal fimbria and the corpus callosum during development, and that this is through the regulation of secretion of fibroblast growth factor-2, a guidance factor for migration of oligodendrocyte precursor cells (OPCs). (nature.com)
A Truncated Version of an Adp-Glucose Pyrophosphorylase Promoter from Potato Specifies Guard Cell-Selective Expression in Transgenic Plants. (mpg.de)

Furthermore, we find that Arf6 in neurons regulates migration of oligodendrocyte precursor cells (OPCs) through facilitating secretion of fibroblast growth factor-2 (FGF-2), a guidance factor for OPC migration. (nature.com)

Also, the availability of recombinant human hematopoietic growth factors has improved supportive care during life-threatening infections in these patients. (medscape.com)

The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms. (embl.de)

ADP-ribosylation factor plays a significant role in the growth of Mucorales. (medscape.com)

Successful mucormycosis treatment requires correction of the underlying risk factor(s), antifungal therapy (traditionally with a polyene), and aggressive surgery. (medscape.com)

It is likely that patient demographics and/or genetic factors influence the response to WTC dust injury and that these contribute to different pathological outcomes. (cdc.gov)

Risk factors such as diabetic ketoacidosis and neutropenia are present in most cases. (medscape.com)
Immunocompromising conditions are the main risk factors for mucormycosis. (medscape.com)
Prior receipt of voriconazole is another risk factor for mucormycosis. (medscape.com)
older iron chelators such as deferoxamine and all causes of iron overload are additional risk factors for mucormycosis. (medscape.com)
Additionally, nonsterile tape and contaminated wooden splints are other risk factors for cutaneous diseases. (medscape.com)
Some patients with mucormycosis have no identifiable risk factors. (medscape.com)

This suggests the presence of an additional activating factor in the active RalA-PLD1 complexes. (embl.de)

ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. (nih.gov)
The ADP-ribosylation factor (Arf) proteins are a family of six small, ubiquitously expressed GTP-binding proteins ( Donaldson and Jackson, 2011 ). (jneurosci.org)
The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. (abnova.com)
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. (duke.edu)
MONOMERIC GTP-BINDING PROTEINS that were initially recognized as allosteric activators of the MONO( ADP-RIBOSE ) TRANSFERASE of the CHOLERA TOXIN catalytic subunit. (nih.gov)
ADP ribosylation factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical components of vesicular trafficking pathways in eukaryotes. (embl.de)
These proteins, called ADP-ribosylation factors, or Arfs, have recently been found to 1) interact with specific lipid components of membranes, 2) modify the lipid composition and release potential second messengers through activation of phospholipase D (PLD), and 3) regulate the assembly of at least a subset of protein complexes or membrane coats (for reviews, see refs. (nih.gov)
GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. (nih.gov)
A family of genes designated as the Zinc finger A20/AN1 Transcription factors encoding stress-associated proteins ( SAP ) are well described in Arabidopsis and rice, and include 14 AtSAP and 18 OsSAP genes that are associated with variable tolerances to multiple abiotic stresses. (biomedcentral.com)
Role of Rho family proteins in phospholipase D activation by growth factors. (wikidata.org)
The proteins involved in the formation of chromatin include histones (H1, H2A, H2B, H3, and H4) as well as a diverse group of proteins such as transcription factors, polymerases, hormone receptors, and nuclear enzymes. (flowmetric.com)

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. (abnova.com)
To date, Stau1 binding to the 3'-untranslated region (3'-UTR) of ADP ribosylation factor (ARF)1 mRNA has been shown to target ARF1 mRNA for Stau1-mediated mRNA decay (SMD). (iric.ca)
ARF1 SMD depends on translation and recruitment of the nonsense-mediated mRNA decay factor Upf1 to the ARF1 3'-UTR by Stau1. (iric.ca)

Growing evidence indicates that the FLNA -dependent actin dynamics and regulation of vesicle formation and trafficking by activation of ADP-ribosylation factors (ARFs) can play an important role in this cortical malformation. (bmj.com)

BRAG1 is a guanine nucleotide exchange factor for the small GTP-binding protein Arf6 that localizes to the postsynaptic density of excitatory synapses. (jneurosci.org)
6. Expression and properties of ADP-ribosylation factor (ARF6) in endocytic pathways. (nih.gov)
8. Exchange factor EFA6R requires C-terminal targeting to the plasma membrane to promote cytoskeletal rearrangement through the activation of ADP-ribosylation factor 6 (ARF6). (nih.gov)
20. Grp1-associated scaffold protein (GRASP) is a regulator of the ADP ribosylation factor 6 (Arf6)-dependent membrane trafficking pathway. (nih.gov)
To study the effector function of the ADP- ribosylation factor (ARF) 6 GTP-binding protein, we transfected HeLa cells with wild-type, epitope-tagged ARF6. (rupress.org)
HN - 2022 BX - ADP Ribosylation Factor 6 BX - ARF6 Protein MH - Aerosolized Particles and Droplets UI - D000088342 MN - D20.65 MS - A suspension of tiny particles or liquid droplets ( (nih.gov)

UNC50 prompts G1/S transition and proliferation in HCC by regulation of epidermal growth factor receptor trafficking. (nih.gov)
The Na+/H+ exchanger regulatory factor (NHERF) binds to the tail of the beta2-adrenergic receptor and plays a role in adrenergic regulation of Na+/H+ exchange. (duke.edu)
the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD). (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. (nih.gov)
Purpose:To delineate gene expression patterns and profile changes in metastatic tumor biopsies at baseline and1month after treatment with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib in patients with metastatic breast cancer. (nih.gov)
Erlotinib is a selective small-molecule inhibitor of the and these mutations cause hypersensitivity to growth inhibition epidermal growth factor receptor tyrosine kinase (EGFR-TK). (nih.gov)
One tumor kinases such as insulin-like growth factor I receptor (IGFIR) and expressed significant levels of EGFR protein and erlotinib had insulin receptor (1, 2). (nih.gov)
Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. (vanderbilt.edu)
A small GTP-binding protein, Rho, associates with the platelet-derived growth factor type-beta receptor upon ligand binding. (wikidata.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Transforming Growth Factor Beta Receptor I (TGFbR1) in Tissue homogenates, cell lysates and other biological fluids. (molepostgazette.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Transforming Growth Factor Beta Receptor I (TGFbR1) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (molepostgazette.com)

Isolation and Expression Analysis of Cdna Clones Encoding a Small and a Large Subunit of Adp-Glucose Pyrophosphorylase from Sugar-Beet. (mpg.de)

Here we show that an autosomal recessive condition characterized by microcephaly and periventricular heterotopia maps to chromosome 20 and is caused by mutations in the gene ADP-ribosylation factor guanine nucleotide-exchange factor-2 (ARFGEF2). (nih.gov)
UNC50 acted by recruiting GBF1, an ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Golgi. (nih.gov)

Description: A competitive ELISA for quantitative measurement of Human ADP ribosylation factor binding protein GGA1(GGA1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (immunoprice.com)
Description: A competitive ELISA for quantitative measurement of Rat ADP ribosylation factor binding protein GGA1(GGA1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (immunoprice.com)

BCAS2 pre-mRNA processing factor [So. (gsea-msigdb.org)
Celastrol administration also improved the anti-inflammatory and anti-oxidative status by inhibiting nuclear factor kappa B (NFκB) activity and the mRNA levels of proinflammatory cytokines and increasing mitochondrial DNA copy number and anti-oxidative stress genes expression in WT mice liver, in vivo and in vitro. (cyberleninka.org)
Celastrol administration also improved the anti-inflammatory and anti-oxidative status by inhibiting nuclear factor kappa B (NFkB) activity and the mRNA levels of proinflammatory cytokines and increasing mitochondrial DNA copy number and anti-oxidative stress genes expression in WT mice liver, in vivo and in vitro. (cyberleninka.org)

Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish. (oregonstate.edu)

Banerjee T, Taylor M, Jobling MG, Burress H, Yang Z, Serrano A, Holmes RK, Tatulian SA, Teter K. ADP-ribosylation factor 6 acts as an allosteric activator for the folded but not disordered cholera toxin A1 polypeptide. (ucdenver.edu)

Inhibition of the Adp-Glucose Pyrophosphorylase in Transgenic Potatoes Leads to Sugar-Storing Tubers and Influences Tuber Formation and Expression of Tuber Storage Protein Genes. (mpg.de)
One of 2 Different Adp-Glucose Pyrophosphorylase Genes from Potato Responds Strongly to Elevated Levels of Sucrose. (mpg.de)
It has been shown that the polarity of leaves and floral organs is defined by the network of genes encoding the Class III Homeodomain Leucine Zipper (HD-ZIPIII), ASYMMETRIC LEAVES (AS1/AS2), KANADI (KAn), AUXIN RESPONSE FACTOR (ARF3/ARF4), and YABBY families of transcription factors [8, 13-15]. (thefreelibrary.com)

Using our cell culture model of human intestinal development, we provide consistent evidence that cholera toxin (CT)-mediated Gs activation in fetal enterocytes differs from that of mature enterocytes, and the difference may be related to ADP-ribosylation factor (ARF) interaction with the CT-signaling process. (scialert.net)

19. ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway. (nih.gov)

Golgicide A is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF), GBF1. (adooq.com)

In addition, GIT1 interacts directly with paxillin and the PIX exchange factors, and indirectly with PAKs, Rac1, and Nck. (bdbiosciences.com)

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity. (vanderbilt.edu)

We also discovered that a transcription factor LEAFY COTYLEDON ( LEC1 ) was highly expressed in the endosperm and that the regulatory cascade downstream of LEC1 operates in the endosperm. (biomedcentral.com)
Our results demonstrate that antigenic strength is a key factor in the generation of IL-10 Treg in vivo, as characterized by changes in proliferative capacity, cytokine secretion, acquisition of regulatory function and protection from EAE. (hdac-assay.com)

The name ADP-ribosylation factor derives from the discovery, in 1984, of the factor that confers sensitivity of the stimulator of adenylate cyclase (Gs) to cholera toxin, an ADP-ribosyltransferase (4). (nih.gov)

The human genome contains 15 Arf-guanine nucleotide exchange factors (GEFs), which catalyze the exchange of GDP for GTP via the evolutionarily conserved catalytic Sec7 domain ( Casanova, 2007 ). (jneurosci.org)

Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors. (abcam.cn)

Íntervienen en el tráfico de vesículas y en la activación de la FOSFOLIPASA D. Esta enzima fue clasificada antiguamente como EC 3.6.1.47. (bvsalud.org)

The virulence factor involved in the pathogenesis of Mucorales is high affinity iron permease (FTR1), allowing Mucorales survival in iron-poor environments. (medscape.com)
What virulence factor is seen in S. Aureus? (studystack.com)

The murine latent transforming growth factor-β binding protein (Ltbp-1) is alternatively spliced, and maps to a region syntenic to human chromosome 2p21-22. (mpg.de)

Identification and embryonic expression of a new AP-2 transcription factor, AP-2 epsilon. (mpg.de)
A Truncated Version of an Adp-Glucose Pyrophosphorylase Promoter from Potato Specifies Guard Cell-Selective Expression in Transgenic Plants. (mpg.de)
The expression of ADP-ribosylation factor (ARF)-like 4c (ARL4C), induced by a combination of the EGF-MAPK pathway and Wnt/beta-catenin signalling, has been shown to induce epithelial morphogenesis. (utu.fi)

14. ADP-ribosylation factor 6 regulation of phosphatidylinositol-4,5-bisphosphate synthesis, endocytosis, and exocytosis. (nih.gov)
HN - 2022 BX - Adolescent Motherhood BX - Teen Mothers BX - Teenage Mothers FX - Pregnancy in Adolescence MH - ADP-Ribosylation Factor 6 UI - D000089982 MN - D8.811.277.40.330.300.400.100.50 MN - D12.776.157.325.515.100.550 MN - D12.776.476.338.400.100.50 MS - A member of GTP-binding protein of the large ras superfamily involved in regulation of membrane trafficking by modulating ENDOCYTOSIS and ACTIN CYTOSKELETON remodeling. (nih.gov)

ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments. (nih.gov)

Focal adhesions serve as nodes to transmit environmental signals initiated by soluble growth factors, ECM, and surrounding mechanical forces to regulate cell growth and migration ( 9 - 11 ). (aacrjournals.org)

Among them, the HD-ZIPIII REVOLUTA (REV) is expressed in the adaxial domain of lateral organs, whereas the GARP-family transcription factors KAN1-4 are involved in abaxial differentiation. (thefreelibrary.com)
Together, a total of 35 drought-inducible transcription factors were identified, including WRKY, MYB and bZIP family members. (biomedcentral.com)
Hh signaling is absolutely dependent on primary cilia, and requires the IFT machinery for the transport and processing of its signaling components in primary cilia, including transmembrane receptors, Ptch1, Smoothened (Smo), and downstream GLI-Kruppel family of transcription factors Gli1-3 as well [ 12 ]. (biomedcentral.com)

Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. (db-engine.de)
Epigenetic modifications can take several different forms from methylation, acetylation, phosphorylation, to ubiquitination, citrullination, and ADP-ribosylation, each of these are regulated independently to modify the chromatin structure and subsequent transcription activities within that region. (flowmetric.com)

GGAs bind cargo, membranes, clathrin and accessory factors. (xfam.org)

Trans-regulation of oligodendrocyte myelination by neurons through small GTPase Arf6-regulated secretion of fibroblast growth... (nature.com)

Mucormycosis (Zygomycosis): Background, Etiology and Pathophysiology, Epidemiology (medscape.com)

RCSB PDB - 1O3X: Crystal structure of human GGA1 GAT domain (rcsb.org)

Frontiers | Causal Inference of Genetic Variants and Genes in Amyotrophic Lateral Sclerosis (frontiersin.org)

Search Ageing-Associated Genes in Model Organisms (genomics.senescence.info)

Negative regulation of signaling - Ontology Report - Rat Genome Database (rgd.mcw.edu)

Hairy Cell Leukemia Medication: Purine Analogues, Interferons, Recombinant Granulocyte Colony-Stimulating Factors (G-CSFs),... (emedicine.medscape.com)

OX1 orexin/hypocretin receptor activation of phospholipase D<... (researchportal.helsinki.fi)

Selected Publications | Max Planck Institute of Biochemistry (biochem.mpg.de)

Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma... (pennstate.pure.elsevier.com)

Anti-arfgap2 antibody (AA 1-521) | Product No. ABIN529675 (antibodies-online.com)

Cancers | Free Full-Text | An Anti-PSMA Immunotoxin Reduces Mcl-1 and Bcl2A1 and Specifically Induces in Combination with the... (mdpi.com)

Tim Stearns' Profile | Stanford Profiles (profiles.stanford.edu)

Anatomy8

Organisms1

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes9

Information Science2

Identification of a new Pyk2 target protein with Arf-GAP activity. (1/1111)

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. (2/1111)

Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. (3/1111)

GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro. (4/1111)

EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization. (5/1111)

Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors. (6/1111)

Characterization of the regulation of phospholipase D activity in the detergent-insoluble fraction of HL60 cells by protein kinase C and small G-proteins. (7/1111)

The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D. (8/1111)

ADP-Ribosylation Factors

ADP-Ribosylation Factor 1

Brefeldin A

Coated Vesicles

Coatomer Protein

Guanine Nucleotide Exchange Factors

GTP-Binding Proteins

Coat Protein Complex I

Golgi Apparatus

GTPase-Activating Proteins

Adenosine Diphosphate Ribose

Phospholipase D

Guanosine 5'-O-(3-Thiotriphosphate)

Guanosine Triphosphate

Nucleoside Diphosphate Sugars

Adenosine Diphosphate Sugars

Endocytosis

Protein Transport

Protein Binding

Ribose

Membrane Proteins

HeLa Cells

ADP Ribose Transferases

Carrier Proteins

Molecular Sequence Data

Cholera Toxin

Recombinant Fusion Proteins

Amino Acid Sequence

Pertussis Toxin

Virulence Factors, Bordetella

Mutation

Adenosine Diphosphate

Poly(ADP-ribose) Polymerases

Cell Membrane

Botulinum Toxins

NAD

Adenylate Cyclase

Adenylate Cyclase Toxin

Poly Adenosine Diphosphate Ribose

Phosphatidylinositol 4,5-Diphosphate

Bacterial Toxins

Kinetics

Adaptor Proteins, Vesicular Transport

rhoA GTP-Binding Protein

Recombinant Proteins

Azaguanine

Intracellular Membranes

Enzyme Activation

Biological Transport

Cell Line

Proteins

NAD+ Nucleosidase

Cloning, Molecular

Tankyrases

Cricetinae

CHO Cells

Mitochondrial ADP, ATP Translocases

Signal Transduction

Cells, Cultured

Identification of a new Pyk2 target protein with Arf-GAP activity. (1/1111)

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. (2/1111)

Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. (3/1111)

GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro. (4/1111)

EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization. (5/1111)

Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors. (6/1111)

Characterization of the regulation of phospholipase D activity in the detergent-insoluble fraction of HL60 cells by protein kinase C and small G-proteins. (7/1111)

The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D. (8/1111)

ADP-ribosylation factor-like tumour-suppressor protein 1 | definition of ADP-ribosylation factor-like tumour-suppressor protein...

ARFGAP1 recombinant protein | ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) Recombinant Protein-NP 001268411.1

Bio2Vec

Myc-DDK-tagged ORF clone of Homo sapiens ADP-ribosylation factor-like 5C (ARL5C) as transfection-ready DNA - RC227851 - 10 µg -...

ADP-ribosylation factor-like protein 3

SYT1 - Arf guanine nucleotide exchange factor SYT1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) -...

WikiGenes - ARL6IP6 - ADP-ribosylation factor-like 6 interacting...

ARL5C (ADP-ribosylation factor-like 5C) - KOMP (Knockout Mouse Project)

ADP ribosylation factor 6 regulates neuronal migration in the developing cerebral cortex through FIP3/arfophilin-1-dependent...

Effect of protein kinase a activity on the association of ADP-ribosylation factor 1 to Golgi membranes

SMART: ArfGap domain annotation

SMART: ArfGap domain annotation

ARL4A acts with GCC185 to modulate Golgi complex organization | Journal of Cell Science