ADP-ribosyl Cyclase
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
Antigens, CD38
Adenylate Cyclase
Guanylate Cyclase
NAD
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Adenylate Cyclase Toxin
Models, Molecular
Adenosine Diphosphate
Purification and characterization of ADP-ribosyl cyclase from Euglena gracilis. (1/575)
ADP-ribosyl cyclase, which catalyzes the conversion from NAD+ to cyclic adenosine diphosphoribose (cADPR), is proposed to participate in cell cycle regulation in Euglena gracilis. This enzyme, which was found as a membrane-bound protein, was purified almost the homogeneity after solubilization with deoxycholate, and found to be a monomeric protein with a molecular mass of 40 kDa. Its Km value for NAD+ was estimated to be 0.4 mM, and cADPR, a product of the enzyme, inhibited the enzyme competitively with respect to NAD+ whereas another product, nicotinamide, showed noncompetitive (mixed-type) inhibition. In contrast to mammalian CD38 and BST-1, Euglena ADP-ribosyl cyclase lacked cADPR hydrolase activity. (+info)Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: relationships to host factors, cellular restoration, and virologic end points. (2/575)
Biphasic plasma viral decays were modeled in 48 patients treated with ritonavir, zidovudine, and lamivudine. Estimated first- and second-phase decay rates were d1 as 0.47/day and d2 as 0.04/day. Interpatient differences in both decay rates were significant. The d1 was directly correlated with baseline CD4+, CD4+CD28+, and CD8+CD28+ T lymphocyte counts (P<.05) and inversely correlated with baseline virus load (P=.044) and the magnitude of CD4+ and CD8+ T lymphocyte recovery (P<.01). The d2 was directly correlated with baseline percentage of CD8+ T lymphocytes (P=.023), the CD8+CD38+ cell number (P=.024), and the level of IgG that binds to human immunodeficiency virus (HIV) type 1 gp120 (P=.02). Viral decay rates were not predictive of treatment failure or durability of viral suppression. These exploratory findings are consistent with a model in which immunologic factors contribute to elimination of HIV-infected cells and suggest a dynamic interplay between regulation of HIV expression and lymphocyte activation and recovery. (+info)Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. (3/575)
To define predictors of survival time in late human immunodeficiency virus type 1 (HIV-1) disease, long- and short-duration survivors were studied after their CD4+ T cells fell to +info)IL-5 induces IgG1 isotype switch recombination in mouse CD38-activated sIgD-positive B lymphocytes. (4/575)
Mouse B cells express CD38, whose ligation by anti-CD38 Ab induces their proliferation and protection from apoptosis. We previously showed that stimulation of mouse splenic B cells with IL-5 together with CS/2, an anti-mouse CD38 mAb, induces production of IgG1 and IgM. Here we examined the role of IL-5 and CS/2 in the expression of germline gamma1 transcripts and the generation of reciprocal products forming DNA circles as byproducts of mu-gamma1 switch recombination. By itself, CS/2 induced significant expression of germline gamma1 transcripts in splenic naive B cells, whereas IL-5 neither induced nor enhanced germline gamma1 expression. Increased cellular content of reciprocal product, which is characteristic of mu-gamma1 recombination, was not observed after culturing B cells with CS/2, but increased reciprocal product, along with high levels of lgG1 secretion, was found when B cells were cultured with CS/2 plus IL-5. Although IL-4 did not, by itself, induce mu-gamma1 recombination in B cells stimulated with CS/2, in conjunction with CS/2 plus IL-5, IL-4 dramatically enhanced sterile gamma1 transcription and IgG1 production. These results demonstrate that CD38 ligation induces only germline gamma1 transcription and that IL-5 promotes both mu-gamma1 switch recombination and lgG1 secretion in an IL-4-independent manner. (+info)Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors. (5/575)
We compared the efficiency of transduction by an HIV-1-based lentiviral vector to that by a Moloney murine leukemia virus (MLV) retroviral vector, using stringent in vitro assays of primitive, quiescent human hematopoietic progenitor cells. Each construct contained the enhanced green fluorescent protein (GFP) as a reporter gene. The lentiviral vector, but not the MLV vector, expressed GFP in nondivided CD34(+) cells (45.5% GFP+) and in CD34(+)CD38(-) cells in G0 (12.4% GFP+), 48 hr after transduction. However, GFP could also be detected short-term in CD34(+) cells transduced with a lentiviral vector that contained a mutated integrase gene. The level of stable transduction from integrated vector was determined after extended long-term bone marrow culture. Both MLV vectors and lentiviral vectors efficiently transduced cytokine-stimulated CD34(+) cells. The MLV vector did not transduce more primitive, quiescent CD34(+)CD38(-) cells (n = 8). In contrast, stable transduction of CD34(+)CD38(-) cells by the lentiviral vector was seen for over 15 weeks of extended long-term culture (9.2 +/- 5.2%, n = 7). GFP expression in clones from single CD34(+)CD38(-) cells confirmed efficient, stable lentiviral transduction in 29% of early and late-proliferating cells. In the absence of growth factors during transduction, only the lentiviral vector was able to transduce CD34(+) and CD34(+)CD38(-) cells (13.5 +/- 2.5%, n = 11 and 12.2 +/- 9.7%, n = 4, respectively). The lentiviral vector is clearly superior to the MLV vector for transduction of quiescent, primitive human hematopoietic progenitor cells and may provide therapeutically useful levels of gene transfer into human hematopoietic stem cells. (+info)The metamorphosis of a molecule: from soluble enzyme to the leukocyte receptor CD38. (6/575)
Human CD38 is a 45-kDa type II membrane glycoprotein with an intricate pattern of expression in leukocytes, although evidence is accumulating of its quite widespread expression in cells of nonvascular origin. CD38 is a member of a nascent eukaryotic gene family encoding cytosolic and membrane-bound enzymes whose substrate is NAD, a coenzyme ubiquitously distributed in nature. Functionally, CD38 is an eclectic molecule with the ability not only to catalyze but also to signal, to mobilize calcium, and to adhere to itself, to hyaluronan, and to other ligands. Interaction with CD38 on various leukocyte subpopulations has profound though diverse consequences on their life-span, but these effects seem to be independent of the enzymatic activity of the molecule. CD38 challenges our expectations of a surface molecule and we must sift through its many guises to unmask its true nature. (+info)Evidence of a role for cyclic ADP-ribose in long-term synaptic depression in hippocampus. (7/575)
Ca2+ released from presynaptic and postsynaptic intracellular stores plays important roles in activity-dependent synaptic plasticity, including long-term depression (LTD) of synaptic strength. At Schaffer collateral-CA1 synapses in the hippocampus, presynaptic ryanodine receptor-gated stores appear to mobilize some of the Ca2+ necessary to induce LTD. Cyclic ADP-ribose (cADPR) has recently been proposed as an endogenous activator of ryanodine receptors in sea urchin eggs and several mammalian cell types. Here, we provide evidence that cADPR-mediated signaling pathways play a key role in inducing LTD. We show that biochemical production of cGMP increases cADPR concentration in hippocampal slices in vitro, and that blockade of cGMP-dependent protein kinase, cADPR receptors, or ryanodine-sensitive Ca2+ stores each prevent the induction of LTD at Schaffer collateral-CA1 synapses. A lack of effect of postsynaptic infusion of either cADPR antagonist indicates a probable presynaptic site of action. (+info)Expression of CD28 and CD38 by CD8+ T lymphocytes in HIV-1 infection correlates with markers of disease severity and changes towards normalization under treatment. The Swiss HIV Cohort Study. (8/575)
The relationship between blood CD8+ T lymphocyte subsets, as defined by CD28 and CD38 expression, and plasma viraemia and CD4+ T cells in HIV-1 infection was investigated. In a cross-sectional study of 46 patients with either no or stable anti-retroviral treatment, there was a strong negative correlation between the percentage of CD8+CD28- and the percentage of CD4+ T cells (r = -0.75, P < 0.0001), and a positive correlation between absolute numbers of CD8+CD28+ and CD4+ T cells (r = 0.56, P < 0.0001). In contrast, the expression of CD38 by CD8+ T lymphocytes correlated primarily with plasma viraemia (e.g. the percentage of CD38+ in CD8bright cells, r = 0.76, P < 0.0001). In the 6 months following triple therapy initiation in 32 subjects, there was a close correlation between changes (delta) in CD8+CD28+ or CD8+CD28- and in CD4+ T cells (e.g. delta % CD8+CD28+ versus delta % CD4+, r = 0.37, P = 0.0002; delta % CD8+CD28- versus delta % CD4+, r = -0.66, P < 0.0001). A marked decline of the number of CD8+ T cells expressing CD38 was also observed. These results suggest the existence of a T cell homeostasis mechanism operating in blood with CD4+ and CD8+CD28+ cells on the one hand, and with CD8+CD28- cells on the other. In addition, the percentage of CD38+ cells in CD8+ cells, generally considered an independent prognostic factor, could merely reflect plasma viral load. (+info)
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ADP-ribosyl cyclase 2 | definition of ADP-ribosyl cyclase 2 by Medical dictionary
EC 3.2.2.5
Ryanodine receptor subtype 2 encodes Ca2+ oscillations activated by acetylcholine via the M2 muscarinic receptor/cADP-ribose...
ADP ribosyl Cyclase - Medical Dictionary online-medical-dictionary.org
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Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38
Human lymphocyte antigen CD38 catalyzes the production of cyclic ADP-ribose. - Oxford Neuroscience
Leukocyte Surface Antigen CD47 - ACROBiosystems
Nitric oxide-induced mobilization of intracellular calcium via the cyclic ADP-ribose signaling pathway. - Department of...
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Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life. - Oxford Neuroscience
7-Deaza-8-bromo-cyclic ADP-ribose, the first membrane-permeant, hydrolysis-resistant cyclic ADP-ribose antagonist. - Department...
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Poly (ADP-Ribosyl) Polymerase 1 Inhibitors: A Patent Review
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Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5...
The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to...
Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives. - Department of Pharmacology
Sperm express a Ca2+-regulated NAADP synthase. - Oxford Cardiovascular Science
Drosophila forkhead homologues are expressed in CD34+HLA-DR- primitive human hematopoietic progenitors<...
A unified mechanism of enzymatic synthesis of two calcium messengers: cyclic ADP-ribose and NAADP
Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels
Murine Stromal Cells Counteract the Loss of Long-Term Culture-Initiating Cell Potential Induced by Cytokines in CD34+CD38low...
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KEGG ENZYME: 3.2.2.6
Antigens, CD38 | Profiles RNS
Inputs and outputs of poly(ADP-ribosyl)ation: relevance to oxidative stress
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Aberrant cyclization affords a C-6 modified cyclic adenosine 5′-diphosphoribose analogue with biological activity in Jurkat T...
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Tumor necrosis factor alpha is a potent synergistic factor for the proliferation of primitive human hematopoietic progenitor...
Frontiers | Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or...
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Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells. -...
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Gene Ontology Classifications
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Association of tyrosine and serine kinases with the B cell surface antigen CD20. Induction via CD20 of tyrosine phosphorylation...
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NAD+ glycohydrolase
... whereas its two products are ADP-ribose and nicotinamide. Unlike ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6), ... "ENZYME - 3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase". enzyme.expasy.org. Retrieved 2022-07-11. Hofmann EC, ... "Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities". Journal of Molecular ... which catalyzes the same reaction, this reaction does not proceed through a cyclic ADP-ribose. This enzyme belongs to the ...
CD31
January 1998). "Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member". Journal of ...
BST1
Overview of all the structural information available in the PDB for UniProt: Q10588 (Human ADP-ribosyl cyclase/cyclic ADP- ... Bst1 (Bone marrow stromal cell antigen 1, ADP-ribosyl cyclase 2, CD157) is an enzyme that in humans is encoded by the BST1 gene ... CD157 and CD38 are both members of the ADP-ribosyl cyclase family of enzymes that catalyze the formation of nicotinamide and ... 2002). "Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities". J. Mol. Biol ...
CD38
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1) at the PDBe-KB. (Articles with short description, Short description matches ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15". Cytogenetics and Cell Genetics. 69 (1-2): 38-9. doi: ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): ...
Nicotinic acid adenine dinucleotide phosphate
... catalyzed by ADP-ribosyl cyclases) which are a family of enzymes that include CD38 and CD157 in mammals (and orthologs in sea ... because genetic knockout or knock-down of ADP-ribosyl cyclases has no effect on NAADP production in some cell types), and there ... "Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate ( ... Lee HC, Zhao YJ (2019). "Resolving the topological enigma in Ca 2+ signaling by cyclic ADP-ribose and NAADP". Journal of ...
Cyclic adenosine monophosphate
Toxins that interfere with enzymes ADP-ribosyl-transferases, and invasive adenylate cyclases. Cholera toxin is an AB toxin that ... Adenylate cyclase is activated by a range of signaling molecules through the activation of adenylate cyclase stimulatory G (Gs ... Adenylate cyclase is inhibited by agonists of adenylate cyclase inhibitory G (Gi)-protein-coupled receptors. Liver adenylate ... This occurs through inhibition of the cAMP-producing enzyme, adenylate cyclase, as a side-effect of glucose transport into the ...
Nicotinamide adenine dinucleotide phosphate
ADP-ribosyl cyclase allows for synthesis from nicotinamide in the salvage pathway, and NADP+ phosphatase can convert NADPH back ...
List of MeSH codes (D08)
... adp-ribosyl cyclase MeSH D08.811.913.400.725.115.680 - pertussis toxin MeSH D08.811.913.400.725.115.690 - poly(adp-ribose) ... adp-ribosyl cyclase MeSH D08.811.277.450.737.400.060.500 - antigens, cd38 MeSH D08.811.277.450.770 - oligo-1,6-glucosidase MeSH ... adenylate cyclase MeSH D08.811.520.650.200.040 - adenylate cyclase toxin MeSH D08.811.520.650.600 - guanylate cyclase MeSH ... adp-ribosylation factors MeSH D08.811.277.040.330.300.400.100.100 - ADP-ribosylation factor 1 MeSH D08.811.277.040.330.300. ...
List of EC numbers (EC 3)
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase EC 3.2.2.7: adenosine nucleosidase EC 3.2.2.8: ribosylpyrimidine nucleosidase ... ADP-ribosyl-[dinitrogen reductase] hydrolase EC 3.2.2.25: N-methyl nucleosidase EC 3.2.2.26: futalosine hydrolase EC 3.2.2.27: ... ADP-dependent short-chain-acyl-CoA hydrolase EC 3.1.2.19: ADP-dependent medium-chain-acyl-CoA hydrolase EC 3.1.2.20: acyl-CoA ... ADP-phosphoglycerate phosphatase EC 3.1.3.29: N-acylneuraminate-9-phosphatase EC 3.1.3.30: The activity may be that of an acid ...
ADP-ribosylation
During the late 1980s, ADP-ribosyl cyclases, which catalyze the addition of cyclic-ADP-ribose groups to proteins, were ... ADP-ribosyl)transferases can perform two types of modifications: mono(ADP-ribosyl)ation and poly(ADP-ribosyl)ation. Mono(ADP- ... ADP-ribosyl)ation and short poly(ADP-ribosyl)ation and serves to activate PARP1. The PARPs have many protein targets at the ... ADP-ribosyl)transferase, has been shown to affect STAT transcription factor binding. Other (ADP-ribosyl)transferases have been ...
Cyclic ADP-ribose
Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD (1996). "Crystal structure of Aplysia ADP-ribosyl cyclase, a homolog ... cADPR is produced from nicotinamide adenine dinucleotide (NAD+) by ADP-ribosyl cyclases (EC 3.2.2.5) as part of a second ... monofunctional ADP ribosyl cyclase of the mollusc Aplysia). The same enzymes are also capable of hydrolyzing cADPR to ADPR. ... Hon Cheung Lee, the discoverer of cyclic ADP-ribose. Cyclic ADP-ribose and NAADP. The first book on these two second messengers ...
ADP-ribosyl cyclase
In enzymology, a ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6) is a bifunctional enzyme that catalyzes the ... "ENZYME - 3.2.2.6 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase". enzyme.expasy.org. Retrieved 2022-07-11. ALIVISATOS SG, ... The reaction proceeds through cyclic ADP-ribose (cADPR) as intermediate, which is then hydrolyzed into ADP-ribose. This makes ... ADP-ribose + nicotinamide The 3 substrates of this enzyme are NAD+ and H2O, whereas its two products are ADP-ribose and ...
AIR synthetase (FGAM cyclase)
5-phospho-β-D-ribosyl)acetamidine ⇌ {\displaystyle \rightleftharpoons } ADP + 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + ... It is a sequential mechanism in which ATP binds first to the enzyme and ADP is released last. This enzyme hydrolyzes ATP to ... The systematic name of this enzyme class is 2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming). Other ... ADP-forming), phosphoribosylaminoimidazole synthetase, and phosphoribosylformylglycinamidine cyclo-ligase. Purines are one of ...
List of EC numbers (EC 2)
... phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase (*) EC 2.4.99.21: dolichyl-phosphooligosaccharide-protein ... ADP-dependent phosphofructokinase EC 2.7.1.147: ADP-dependent glucokinase EC 2.7.1.148: 4-(cytidine 5′-diphospho)-2-C-methyl-D- ... NAD+ ADP-ribosyltransferase EC 2.4.2.31: NAD+-protein-arginine ADP-ribosyltransferase EC 2.4.2.32: dolichyl-phosphate D- ... NAD+-diphthamide ADP-ribosyltransferase EC 2.4.2.37: NAD+ -dinitrogen-reductase ADP-D-ribosyltransferase EC 2.4.2.38: ...
Nicotinamide adenine dinucleotide
... which is produced from NAD+ by ADP-ribosyl cyclases, as part of a second messenger system. This molecule acts in calcium ... Poly(ADP-ribosyl)ation is carried out by the poly(ADP-ribose) polymerases. The poly(ADP-ribose) structure is involved in the ... or the transferral of ADP-ribose to proteins in long branched chains, which is called poly(ADP-ribosyl)ation. Mono-ADP- ... ADP-ribosylation involves either the addition of a single ADP-ribose moiety, in mono-ADP-ribosylation, ...
Purine metabolism
fGAR + L-Glutamine + ATP → fGAM + L-Glutamate + ADP + Pi The fifth is catalyzed by AIR synthetase (FGAM cyclase). fGAM + ATP → ... A key regulatory step is the production of 5-phospho-α-D-ribosyl 1-pyrophosphate (PRPP) by ribose phosphate pyrophosphokinase, ... PRPP + L-Glutamine + H2O → PRA + L-Glutamate + PPi In the second step react PRA, glycine and ATP to create GAR, ADP, and ... CAIR + L-Aspartate + ATP → SAICAR + ADP + Pi The eight is catalyzed by adenylosuccinate lyase. SAICAR → AICAR + Fumarate The ...
Cluster of Excellence Frankfurt Macromolecular Complexes
Mass spectrometry analysis revealed that SidJ is a glutamylase that modifies the catalytic glutamate in the mono-ADP ribosyl ... They also established the tightly light-regulated guanylyl-cyclase opsin CyclOp that enabled rapid light-triggered cGMP ... In addition, they studied synaptic transmission after photostimulation, using ChR2 and a photoactivated adenylyl cyclase (PAC ... "Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp". Nat Commun ...
No data available that match "adp ribosyl cyclase"
Changed and Deleted MeSH Headings-2018. NLM Technical Bulletin. 2017 Nov-Dec
3I9L: Crystal structure of ADP ribosyl cyclase complexed with N1-cIDPR - Department of Pharmacology
Identification and localisation of novel ADP-ribosyl cyclases in sea urchin eggs - Department of Pharmacology
CD38/ADP-ribosyl cyclase in the rat sublingual gland: Subcellular localization under resting and saliva-secreting conditions<...
CD38/ADP-ribosyl cyclase in the rat sublingual gland: Subcellular localization under resting and saliva-secreting conditions. ... CD38/ADP-ribosyl cyclase in the rat sublingual gland : Subcellular localization under resting and saliva-secreting conditions. ... CD38/ADP-ribosyl cyclase in the rat sublingual gland : Subcellular localization under resting and saliva-secreting conditions. ... T1 - CD38/ADP-ribosyl cyclase in the rat sublingual gland. T2 - Subcellular localization under resting and saliva-secreting ...
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Publication Detail
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ADP-Ribosyl Cyclase as a Therapeutic Target for Central Nervous System Diseases. Journal: Central Nervous System Agents in ... Poly (ADP-Ribosyl) Polymerase 1 Inhibitors: A Patent Review. Journal: Recent Patents on Anti-Cancer Drug Discovery. Volume: 12 ... Poly(ADP-Ribosyl)ation Enzyme-1 as a Target for Neuroprotection in Acute Central Nervous System Injury. Journal: Current Drug ... ADP-Ribosyltransferases and Poly ADP-Ribosylation. Journal: Current Protein & Peptide Science. Volume: 16 Issue: 6 Year: 2015 ...
Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder - PubMed
Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological...
CD38 Antibody, Biotin (13-0381-82)
... phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; cADPr ... Protein Aliases: 2-phospho-ADP-ribosyl cyclase; 2-phospho-ADP-ribosyl cyclase/2-phospho-cyclic-ADP-ribose transferase; 2- ... CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ ... CD38, a counter-receptor for CD31, is an ectoenzyme with cyclase and hydrolase enzymatic activity and is speculated to play a ...
R718 Mouse Anti-Human CD157
It is an ectoenzyme that has both cyclic ADP-ribose hydrolase and ADP-ribosyl cyclase activities. CD157 is expressed as a ... It is an ectoenzyme that has both cyclic ADP-ribose hydrolase and ADP-ribosyl cyclase activities. CD157 is expressed as a ... ADP-ribosyl cyclase 2, and cADPr hydrolase 2. CD157 is a 40-46 kDa glycophosphatidylinositol-linked cell membrane glycoprotein ... ADP-ribosyl cyclase 2, and cADPr hydrolase 2. CD157 is a 40-46 kDa glycophosphatidylinositol-linked cell membrane glycoprotein ...
APC/Cyanine7 anti-human CD38 Antibody anti-CD38 - HIT2
T10, ADP-ribosyl cyclase Isotype Mouse IgG1, κ Ave. Rating Submit a Review Product Citations publications Human peripheral ... Ecto-ADP-ribosyl cyclase, calcium signaling, cell activation Ligand/Receptor CD31, hyaluronic acid Cell Type B cells, Dendritic ... ADP-ribosyl cyclase, ectoenzyme, type II glycoprotein, 45 kD Distribution T cells, B cells, NK, myeloid, plasma, and dendritic ... It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such ...
KAKEN - Research Projects | ATP合成酵素の高次構造 (KAKENHI-PROJECT-04266104)
ADP-ribosyl cyclase/Cyclic ADP-ribose hydrolase)to chromosome 4p15. Cytogenet.Cell Genet.69. 38-39 (1995). *. Related Report. ... Cloning and characterization of cDNA encoding rat ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase(homologue to human CD38)from ... Publications] Y.Hirata,Y.Ohsugi,H.Okamoto,T.Kaisho,T.Hirano,et all.: ADP ribosyl cyclase activity of a novel bone marrow ... The structure of the Aplysia kurodai gene encoding ADP-ribosyl cyclase,a secondmessenger enzyme. Gene.(in press).. *. Related ...
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British Library EThOS: Novel dinucleotides, precursors to fluorescent cyclic nucleotides
cADPR is a Ca 2 -modulating second messenger formed by the cyclisation of NAD+ by ADP-ribosyl cyclases. While three different ... In addition; NAD is a precursor to biologically active metabolites such as ADPR, ADP_ribosyl-derivatives and cADPR. ... The aim of this work is thus to synthesise base-modified NAD+ analogues that can reach the cyclase active site, and be ... Such analogues may facilitate establishing the location and mechanism of the cyclase and also the metabolic pathway of cADPR. ...
MeSH Browser
ADP-ribosyl Cyclase [D08.811.277.450.430.400.060] * ADP-ribosyl Cyclase 1 [D08.811.277.450.430.400.060.500] ... 2-Phospho-adenosine Diphosphate Ribose Cyclase ADP Ribose Cyclase ADPR Cyclase Adenosine Diphosphate Ribose Cyclase Cyclic ADP ... ADP Ribose Transferases [D08.811.913.400.725.115] * NAD+ Nucleosidase [D08.811.913.400.725.115.660] * ADP-ribosyl Cyclase [ ... and sometimes the synthesis of cyclic ADP-ribose 2 phosphate (2-P-cADPR) from NADP.. Terms. ADP-ribosyl Cyclase Preferred ...
MSP scholars research work - IsDB Alumni & Science Development Network (IDB ASDN)
Morphological, immunophenotypic, and genetic features of chronic lymphocytic leukemia with trisomy 12: a comprehensive review
...
Phenotypic and functional characterization of committed and primitive myeloid and lymphoid hematopoietic precursors in human...
MeSH Browser
ADP-ribosyl Cyclase [D08.811.277.450.430.400.060] * ADP-ribosyl Cyclase 1 [D08.811.277.450.430.400.060.500] ... 2-Phospho-adenosine Diphosphate Ribose Cyclase ADP Ribose Cyclase ADPR Cyclase Adenosine Diphosphate Ribose Cyclase Cyclic ADP ... ADP Ribose Transferases [D08.811.913.400.725.115] * NAD+ Nucleosidase [D08.811.913.400.725.115.660] * ADP-ribosyl Cyclase [ ... and sometimes the synthesis of cyclic ADP-ribose 2 phosphate (2-P-cADPR) from NADP.. Terms. ADP-ribosyl Cyclase Preferred ...
ugt1a10 gene|ugt1a10 gene|C1421323|udp glucuronosyltransferase 1 family, polypeptide a10|gngm
... bpoc adp-ribosyl cyclase/cyclic adp-ribose hydrolase,adp-ribosyl cyclase\/cyclic adp-ribose hydrolase,C1413221,cd38 molecule ... guanylate cyclase, soluble, beta-2,gngm female genital vein,female genital vein,C0729954,female genital vein,bpoc cacna1a, ... trf1-interacting ankyrin-related adp-ribose polymerase wt allele,gngm tinf2,tinf2,C1336631,tinf2,gngm pc,pc,C1418943,proc,gngm ...
Y.s. Prakash - Research output - Mayo Clinic
Subcellular localization of cyclic ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities in porcine airway smooth ... Role of cyclic ADP-ribose in the regulation of [Ca2+](i) in porcine tracheal smooth muscle. Prakash, Y. S., Kannan, M. S., ... The Role of Cyclic-ADP-Ribose-Signaling Pathway in Oxytocin-Induced Ca 2+ Transients in Human Myometrium Cells. Barata, H., ... Soluble guanylate cyclase modulators blunt hyperoxia effects on calcium responses of developing human airway smooth muscle. ...
Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii - Fingerprint ...
CD3811
- The type II transmembrane glycoprotein CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) has been proposed as a mediator of insulin secretion from pancreatic β-cells and as a candidate for autoimmune reactions in type 2 diabetes. (elsevier.com)
- By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. (biolegend.com)
- 10 mU/mg, as measured under the described conditions using BioVision's CD38 (Cyclase) Activity Assay Kit (Cat. (transcriptionfactor.org)
- CD38, also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. (transcriptionfactor.org)
- CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. (transcriptionfactor.org)
- Biomolecule/Target: CD38Synonyms: CD38, T10, cADPr hydrolase 1Alternates names: CD38, T10, cADPr hydrolase 1Taglines: Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine. (transcriptionfactor.org)
- Both are metabolites of pyridine nucleotides, and may be produced by the same class of enzymes, ADP-ribosyl cyclases, such as CD38. (ox.ac.uk)
- 20,Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology. (nmninfo.com)
- The signaling cascade triggered by ABA in insulin releasing cells sequentially involves a pertussis toxin-sensitive G protein, cAMP overproduction, protein kinase A-mediated activation of the ADP-ribosyl cyclase CD38, and cyclic ADP-ribose overproduction. (unige.it)
- We found that HOBIT human osteoblastic cells, which are known to express ADP-ribosyl cyclase/CD38 activity, respond to micromolar concentrations of extracellular NAD(+) with oscillatory increases of the cytosolic Ca(2+) concentration. (heightquest.com)
- remain to be clearly identified (20), although members of the ADP-ribosyl cyclase family are possibly involved because the purified CD38 and ADP-ribosyl cyclases have been shown to be capable of NAADP synthesis (21,C23). (casein-kinases.com)
Hydrolase2
- In enzymology, a ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6) is a bifunctional enzyme that catalyzes the chemical reaction NAD+ + H2O ⇌ {\displaystyle \rightleftharpoons } cADPR + H2O + nicotinamide ⇌ {\displaystyle \rightleftharpoons } ADP-ribose + nicotinamide The 3 substrates of this enzyme are NAD+ and H2O, whereas its two products are ADP-ribose and nicotinamide. (wikipedia.org)
- It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscles, and kidney). (biolegend.com)
Cyclic ADP-ribose and nicotinate-ade1
- Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. (euromabnet.com)
NAADP2
- From trials, NAADP and the related Ca2+-mobilizing messenger, cyclic ADP-ribose (cADPR) can end up being synthesized by Compact disc38 using alternative substrates and with different pH dependences (24). (casein-kinases.com)
- Rabbit Polyclonal to OR2B6 Nevertheless, amazingly, just one research provides connected the creation of endogenous NAADP to any member of the ADP-ribosyl cyclase family members (25) and a physical function for Compact disc38 as an NAADP synthase provides been reigned over out by some (17, 18). (casein-kinases.com)
Enzymes2
- In mammals, mono-ADP-ribosylation serves to regulate protein functions, and it is catalysed by two families of toxin-related cellular ADP-ribosyltransferases: ecto-enzymes that modify various cell-surface proteins, like integrins and receptors, and intracellular enzymes that act on a variety of nuclear and cytosolic proteins. (imrpress.com)
- 16,Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. (nmninfo.com)
Poly2
- 17,New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. (nmninfo.com)
- G244-LM is a potent and specific small-molecule tankyrase inhibitors, which reduces Wnt/β-catenin signaling by preventing poly(ADP-ribosyl)ation-dependent AXIN degradation, thereby promoting β-catenin destabilization. (biochempartner.com)
Enzyme1
- 2008 ) Regulation of nuclear Ca2+ signaling by translocation of the Ca2+ messenger synthesizing enzyme ADP-ribosyl cyclase during neuronal depolarization. (neurotree.org)
Enzymatic3
- First enzymatic synthesis of an N1-cyclised cADPR (cyclic-ADP ribose) analogue with a hypoxanthine partial structure: discovery of a membrane permeant cADPR agonist. (ox.ac.uk)
- Mono-ADP-ribosylation is a post-translational modification that was discovered more than five decades ago, and it consists of the enzymatic transfer of ADP-ribose from NAD + to acceptor proteins. (imrpress.com)
- Edema factor, the enzymatic A subunit of EdTx, is an adenylate cyclase. (aai.org)
Intracellular1
- Recently, new examples of ADP-ribosylation of proteins involved in signal transduction and intracellular trafficking have been discovered, thus opening the route to the better molecular understanding of this reaction and of its role in human cell physiology and pathology. (imrpress.com)
Proteins1
- In addition, two members of the structurally non-related sirtuin family can also modify cellular proteins by mono-ADP-ribosylation. (imrpress.com)
Mechanism1
- In viruses and prokaryotes, mono-ADP-ribosylation is mainly, but not exclusively, a mechanism used to take control of the host cell. (imrpress.com)
Reaction1
- The reaction proceeds through cyclic ADP-ribose (cADPR) as intermediate, which is then hydrolyzed into ADP-ribose. (wikipedia.org)
Human2
- Nicotinamide 8-Br-hypoxanthine dinucleotide (8-Br-NHD+) was cyclised at the N1 position by the ADP-ribosyl cyclase from Aplysia californica to give cyclic 8-Br-inosine diphosphoribose (8-Br-N1-cIDPR), a novel membrane-permeant agonist of Ca2+ release in human T cells. (ox.ac.uk)
- Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP-ribose as second messenger. (unige.it)
Products1
- Diadenosine homodinucleotide products of ADP-ribosyl cyclases behave as modulators of the purinergic receptor P2X7. (unige.it)
Cyclic3
- We examined lysates and microsomes of T. gondii and detected evidence of cADPR (cyclic ADP ribose) cyclase and hydrolase activities, the two enzymes that control the second messenger cADPR, which causes calcium release from RyR (ryanodine receptor). (elsevier.com)
- Spatiotemporal Changes in NADH and Cyclic ADP Ribose During Ischemia One of the strengths of IMS lies in its ability to identify metabolites in a nontargeted manner. (cancer-ecosystem.com)
- In this study, NADH and cyclic ADP-ribose (cADPR) are among such metabolites identified retrospectively by tandem MS/MS analyses (Table 1). (cancer-ecosystem.com)
Ectoenzyme1
- Abstract: CD157 is a GPI-anchored ectoenzyme belonging to the NADase/ADP-ribosyl cyclase gene family involved in the control of human neutrophils and monocytes adhesion, migration and diapedesis. (unito.it)
Hematopoietic1
- It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscles, and kidney). (biolegend.com)
Inhibitor2
- Maps for ATP, ADP, and BYL719 inhibitor database AMP are constructed on the same tissue. (cancer-ecosystem.com)
- A poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. (mt911.com)
Antigen1
- BST-1(bone marrow stromal cell antigen 1), also named as CD157 or ADP-ribosyl cyclase 2, is a glycosyl phosphotidylinositol-anchored protein that stimulates pre-B-cell growth and has adenosine diphosphate (ADP)-ribosyl cyclase and cyclic ADP-ribose (cADPR) hydrolase activity (PMID: 9473467, 11866528). (ptglab.com)
Guanylyl cyclase2
- Since the Ca2+-mobilizing effects of NO can be mimicked by cGMP, are inhibited by the cGMP-dependent-protein kinase inhibitor, Rp-8-pCPT-cGMPS, and in egg homogenates show a requirement for the guanylyl cyclase substrate, GTP, we suggest a novel action of NO in mobilizing intracellular calcium from microsomal stores via a signaling pathway involving cGMP and cADPR. (ox.ac.uk)
- However, to date, the upstream guanylyl cyclase (GC) subtype eliciting cGMP production is unknown. (frontiersin.org)
CD1572
- Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. (expasy.org)
- Titolo: Functional Role and Prognostic Significance of CD157 in Ovarian Carcinoma Abstract: Background: CD157, an ADP-ribosyl cyclase-related cell surface molecule, regulates leukocyte diapedesis during inflammation. (unito.it)
Ribose7
- A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide ( NAD ). (nih.gov)
- This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE , as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP . (nih.gov)
- A bifunctional enzyme that catalyzes the synthesis and HYDROLYSIS of CYCLIC ADP-RIBOSE (cADPR) from NAD+ to ADP-RIBOSE. (lookformedical.com)
- mice that absence the main calcium-mobilizing second messenger cyclic ADP ribose. (bus2226w16.com)
- Nitric oxide-induced mobilization of intracellular calcium via the cyclic ADP-ribose signaling pathway. (ox.ac.uk)
- Cyclic adenosine diphosphate ribose (cADPR) is a potent endogenous calcium-mobilizing agent synthesized from beta-NAD+ by ADP-ribosyl cyclases in sea urchin eggs and in several mammalian cells (Galione, A., and White, A. (1994) Trends Cell Biol. (ox.ac.uk)
- OHCs in these frequency regions in young GC-A knockout mice exhibited diminished levels of KCNQ4 expression, which is the dominant K + channel in OHCs, and decreased activation of poly (ADP-ribose) polymerase-1, an enzyme involved in DNA repair. (frontiersin.org)
ADPR1
- NAD is a precursor to biologically active metabolites such as ADPR, ADP_ribosyl-derivatives and cADPR. (bl.uk)
Enzymes1
- While three different enzymes have been identified as cyclases, the mechanism and site of activity of such enzymes has not yet been fully established. (bl.uk)
Protein3
- Protein mono-ADP-ribosylation is a reversible post-translational modification that plays a role in the regulation of cellular activities [4]. (enzyme-database.org)
- The enzyme from some, but not all, species can also use NADP + as acceptor (giving rise to N ω -[(2′-phospho-ADP)- D -ribosyl]-protein- L -arginine as the product), but more slowly [1,5]. (enzyme-database.org)
- Corda, D. and Di Girolamo, M. Functional aspects of protein mono-ADP-ribosylation. (enzyme-database.org)
Activity1
- In the rat, we have previously reported strong ADP-ribosyl cyclase activity in the sublingual salivary gland (Masuda W. and Noguchi T. Biochem. (elsevier.com)
Activation1
- The enzyme catalyses the NAD + -dependent activation of EC 4.6.1.1 , adenylate cyclase. (enzyme-database.org)
Cells1
- The aim of this work is thus to synthesise base-modified NAD+ analogues that can reach the cyclase active site, and be enzymatically converted to cyclic products that fluoresce at wavelengths not harmful to cells. (bl.uk)
Second messenger1
- cADPR is a Ca 2 -modulating second messenger formed by the cyclisation of NAD+ by ADP-ribosyl cyclases. (bl.uk)