ADP-ribosyl Cyclase: A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.Antigens, CD38: A bifunctional enzyme that catalyzes the synthesis and HYDROLYSIS of CYCLIC ADP-RIBOSE (cADPR) from NAD+ to ADP-RIBOSE. It is a cell surface molecule which is predominantly expressed on LYMPHOID CELLS and MYELOID CELLS.Adenylate Cyclase: An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 4.6.1.1.Ribose: A pentose active in biological systems usually in its D-form.Guanylate Cyclase: An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.NAD+ NucleosidaseNAD: A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)Adenylate Cyclase Toxin: One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLYL CYCLASES and hemolysin components.Kinetics: The rate dynamics in chemical or physical systems.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
(1/575) Purification and characterization of ADP-ribosyl cyclase from Euglena gracilis.

ADP-ribosyl cyclase, which catalyzes the conversion from NAD+ to cyclic adenosine diphosphoribose (cADPR), is proposed to participate in cell cycle regulation in Euglena gracilis. This enzyme, which was found as a membrane-bound protein, was purified almost the homogeneity after solubilization with deoxycholate, and found to be a monomeric protein with a molecular mass of 40 kDa. Its Km value for NAD+ was estimated to be 0.4 mM, and cADPR, a product of the enzyme, inhibited the enzyme competitively with respect to NAD+ whereas another product, nicotinamide, showed noncompetitive (mixed-type) inhibition. In contrast to mammalian CD38 and BST-1, Euglena ADP-ribosyl cyclase lacked cADPR hydrolase activity.  (+info)

(2/575) Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: relationships to host factors, cellular restoration, and virologic end points.

Biphasic plasma viral decays were modeled in 48 patients treated with ritonavir, zidovudine, and lamivudine. Estimated first- and second-phase decay rates were d1 as 0.47/day and d2 as 0.04/day. Interpatient differences in both decay rates were significant. The d1 was directly correlated with baseline CD4+, CD4+CD28+, and CD8+CD28+ T lymphocyte counts (P<.05) and inversely correlated with baseline virus load (P=.044) and the magnitude of CD4+ and CD8+ T lymphocyte recovery (P<.01). The d2 was directly correlated with baseline percentage of CD8+ T lymphocytes (P=.023), the CD8+CD38+ cell number (P=.024), and the level of IgG that binds to human immunodeficiency virus (HIV) type 1 gp120 (P=.02). Viral decay rates were not predictive of treatment failure or durability of viral suppression. These exploratory findings are consistent with a model in which immunologic factors contribute to elimination of HIV-infected cells and suggest a dynamic interplay between regulation of HIV expression and lymphocyte activation and recovery.  (+info)

(3/575) Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.

To define predictors of survival time in late human immunodeficiency virus type 1 (HIV-1) disease, long- and short-duration survivors were studied after their CD4+ T cells fell to +info)

(4/575) IL-5 induces IgG1 isotype switch recombination in mouse CD38-activated sIgD-positive B lymphocytes.

Mouse B cells express CD38, whose ligation by anti-CD38 Ab induces their proliferation and protection from apoptosis. We previously showed that stimulation of mouse splenic B cells with IL-5 together with CS/2, an anti-mouse CD38 mAb, induces production of IgG1 and IgM. Here we examined the role of IL-5 and CS/2 in the expression of germline gamma1 transcripts and the generation of reciprocal products forming DNA circles as byproducts of mu-gamma1 switch recombination. By itself, CS/2 induced significant expression of germline gamma1 transcripts in splenic naive B cells, whereas IL-5 neither induced nor enhanced germline gamma1 expression. Increased cellular content of reciprocal product, which is characteristic of mu-gamma1 recombination, was not observed after culturing B cells with CS/2, but increased reciprocal product, along with high levels of lgG1 secretion, was found when B cells were cultured with CS/2 plus IL-5. Although IL-4 did not, by itself, induce mu-gamma1 recombination in B cells stimulated with CS/2, in conjunction with CS/2 plus IL-5, IL-4 dramatically enhanced sterile gamma1 transcription and IgG1 production. These results demonstrate that CD38 ligation induces only germline gamma1 transcription and that IL-5 promotes both mu-gamma1 switch recombination and lgG1 secretion in an IL-4-independent manner.  (+info)

(5/575) Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors.

We compared the efficiency of transduction by an HIV-1-based lentiviral vector to that by a Moloney murine leukemia virus (MLV) retroviral vector, using stringent in vitro assays of primitive, quiescent human hematopoietic progenitor cells. Each construct contained the enhanced green fluorescent protein (GFP) as a reporter gene. The lentiviral vector, but not the MLV vector, expressed GFP in nondivided CD34(+) cells (45.5% GFP+) and in CD34(+)CD38(-) cells in G0 (12.4% GFP+), 48 hr after transduction. However, GFP could also be detected short-term in CD34(+) cells transduced with a lentiviral vector that contained a mutated integrase gene. The level of stable transduction from integrated vector was determined after extended long-term bone marrow culture. Both MLV vectors and lentiviral vectors efficiently transduced cytokine-stimulated CD34(+) cells. The MLV vector did not transduce more primitive, quiescent CD34(+)CD38(-) cells (n = 8). In contrast, stable transduction of CD34(+)CD38(-) cells by the lentiviral vector was seen for over 15 weeks of extended long-term culture (9.2 +/- 5.2%, n = 7). GFP expression in clones from single CD34(+)CD38(-) cells confirmed efficient, stable lentiviral transduction in 29% of early and late-proliferating cells. In the absence of growth factors during transduction, only the lentiviral vector was able to transduce CD34(+) and CD34(+)CD38(-) cells (13.5 +/- 2.5%, n = 11 and 12.2 +/- 9.7%, n = 4, respectively). The lentiviral vector is clearly superior to the MLV vector for transduction of quiescent, primitive human hematopoietic progenitor cells and may provide therapeutically useful levels of gene transfer into human hematopoietic stem cells.  (+info)

(6/575) The metamorphosis of a molecule: from soluble enzyme to the leukocyte receptor CD38.

Human CD38 is a 45-kDa type II membrane glycoprotein with an intricate pattern of expression in leukocytes, although evidence is accumulating of its quite widespread expression in cells of nonvascular origin. CD38 is a member of a nascent eukaryotic gene family encoding cytosolic and membrane-bound enzymes whose substrate is NAD, a coenzyme ubiquitously distributed in nature. Functionally, CD38 is an eclectic molecule with the ability not only to catalyze but also to signal, to mobilize calcium, and to adhere to itself, to hyaluronan, and to other ligands. Interaction with CD38 on various leukocyte subpopulations has profound though diverse consequences on their life-span, but these effects seem to be independent of the enzymatic activity of the molecule. CD38 challenges our expectations of a surface molecule and we must sift through its many guises to unmask its true nature.  (+info)

(7/575) Evidence of a role for cyclic ADP-ribose in long-term synaptic depression in hippocampus.

Ca2+ released from presynaptic and postsynaptic intracellular stores plays important roles in activity-dependent synaptic plasticity, including long-term depression (LTD) of synaptic strength. At Schaffer collateral-CA1 synapses in the hippocampus, presynaptic ryanodine receptor-gated stores appear to mobilize some of the Ca2+ necessary to induce LTD. Cyclic ADP-ribose (cADPR) has recently been proposed as an endogenous activator of ryanodine receptors in sea urchin eggs and several mammalian cell types. Here, we provide evidence that cADPR-mediated signaling pathways play a key role in inducing LTD. We show that biochemical production of cGMP increases cADPR concentration in hippocampal slices in vitro, and that blockade of cGMP-dependent protein kinase, cADPR receptors, or ryanodine-sensitive Ca2+ stores each prevent the induction of LTD at Schaffer collateral-CA1 synapses. A lack of effect of postsynaptic infusion of either cADPR antagonist indicates a probable presynaptic site of action.  (+info)

(8/575) Expression of CD28 and CD38 by CD8+ T lymphocytes in HIV-1 infection correlates with markers of disease severity and changes towards normalization under treatment. The Swiss HIV Cohort Study.

The relationship between blood CD8+ T lymphocyte subsets, as defined by CD28 and CD38 expression, and plasma viraemia and CD4+ T cells in HIV-1 infection was investigated. In a cross-sectional study of 46 patients with either no or stable anti-retroviral treatment, there was a strong negative correlation between the percentage of CD8+CD28- and the percentage of CD4+ T cells (r = -0.75, P < 0.0001), and a positive correlation between absolute numbers of CD8+CD28+ and CD4+ T cells (r = 0.56, P < 0.0001). In contrast, the expression of CD38 by CD8+ T lymphocytes correlated primarily with plasma viraemia (e.g. the percentage of CD38+ in CD8bright cells, r = 0.76, P < 0.0001). In the 6 months following triple therapy initiation in 32 subjects, there was a close correlation between changes (delta) in CD8+CD28+ or CD8+CD28- and in CD4+ T cells (e.g. delta % CD8+CD28+ versus delta % CD4+, r = 0.37, P = 0.0002; delta % CD8+CD28- versus delta % CD4+, r = -0.66, P < 0.0001). A marked decline of the number of CD8+ T cells expressing CD38 was also observed. These results suggest the existence of a T cell homeostasis mechanism operating in blood with CD4+ and CD8+CD28+ cells on the one hand, and with CD8+CD28- cells on the other. In addition, the percentage of CD38+ cells in CD8+ cells, generally considered an independent prognostic factor, could merely reflect plasma viral load.  (+info)

*  NAD+ nucleosidase
"Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities". J. Mol. Biol. 316 (3 ... ADP-ribose + nicotinamide Thus, the two substrates of this enzyme are NAD+ and H2O, whereas its two products are ADP-ribose and ...
*  CD31
ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member". J. Immunol. 160 (1): 395-402. PMID 9551996. ...
*  CD38
1995). "Assignment of CD38, the gene encoding human leukocyte antigen CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), ... 1997). "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing". Gene. 186 (2): ... 1998). "Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member". J. Immunol. 160 (1): 395-402 ...
*  BST1
ADP-ribosyl cyclase 2 is an enzyme that in humans is encoded by the BST1 gene. Bone marrow stromal cell antigen-1 is a stromal ... 2002). "Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities". J. Mol. Biol ... 1996). "Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity". Biochem. ...
*  Cyclic ADP-ribose
Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD (1996). "Crystal structure of Aplysia ADP-ribosyl cyclase, a homolog ... cADPR is produced from nicotinamide adenine dinucleotide (NAD+) by ADP-ribosyl cyclases (EC 3.2.2.5) as part of a second ... monofunctional ADP ribosyl cyclase of the mollusc Aplysia). The same enzymes are also capable of hydrolyzing cADPR to ADPR. ... Hon Cheung Lee, the discoverer of cyclic ADP-ribose. Cyclic ADP-ribose and NAADP. The first book on these two second messengers ...
*  ADP-ribosylation
During the late 1980s, ADP-ribosyl cyclases, which catalyze the addition of cyclic-ADP-ribose groups to proteins, were ... ADP-ribosyltransferases can perform two types of modifications: mono-ADP ribosylation and poly-ADP ribosylation. Mono-ADP ... ADP-ribose) glycohydrolase, an enzyme that hydrolyses poly(ADP-ribose) to produce free ADP-ribose. Studies have shown poly-ADP- ... Hayaishi, O.; Ueda, K. (2012). Poly- and Mono(ADP-ribosyl)ation Reactions: Their Significance in Molecular Biology. In ADP- ...
*  Nicotinic acid adenine dinucleotide phosphate
... catalyzed by ADP-ribosyl cyclases) which are a family of enzymes that include CD38 and CD157 in mammals (and orthologs in sea ... because genetic knockout or knock-down of ADP-ribosyl cyclases has no effect on NAADP production in some cell types), and there ... "Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate ( ... Cyclic ADP-ribose IP3 Clapper, David L.; Walseth, Timothy F.; Dargie, Peter J.; Lee, Hon Cheung (1987). "Pyridine Nucleotide ...
*  List of MeSH codes (D08)
... adp-ribosyl cyclase MeSH D08.811.913.400.725.115.680 --- pertussis toxin MeSH D08.811.913.400.725.115.690 --- poly(adp-ribose) ... adp-ribosyl cyclase MeSH D08.811.277.450.737.400.060.500 --- antigens, cd38 MeSH D08.811.277.450.770 --- oligo-1,6-glucosidase ... adenylate cyclase MeSH D08.811.520.650.200.040 --- adenylate cyclase toxin MeSH D08.811.520.650.600 --- guanylate cyclase MeSH ... adp-ribosylation factors MeSH D08.811.277.040.330.300.400.100.100 --- ADP-ribosylation factor 1 MeSH D08.811.277.040.330.300. ...
*  AIR synthetase (FGAM cyclase)
5-phospho-β-D-ribosyl)acetamidine ⇌ {\displaystyle \rightleftharpoons } ADP + 5-amino-1-(5-phospho-β-D-ribosyl)imidazole + ... It is a sequential mechanism in which ATP binds first to the enzyme and ADP is released last. This enzyme hydrolyzes ATP to ... The systematic name of this enzyme class is 2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming). Other ... ADP-forming), phosphoribosylaminoimidazole synthetase, and phosphoribosylformylglycinamidine cyclo-ligase. Purines are one of ...
*  Nicotinamide adenine dinucleotide
... which is produced from NAD+ by ADP-ribosyl cyclases, as part of a second messenger system. This molecule acts in calcium ... Poly(ADP-ribosyl)ation is carried out by the poly(ADP-ribose) polymerases. The poly(ADP-ribose) structure is involved in the ... or the transferral of ADP-ribose to proteins in long branched chains, which is called poly(ADP-ribosyl)ation. Mono-ADP- ... ADP-ribosylation involves either the addition of a single ADP-ribose moiety, in mono-ADP-ribosylation, ...
*  Purine metabolism
fGAR + L-Glutamine + ATP → fGAM + L-Glutamate + ADP + Pi The fifth is catalyzed by AIR synthetase (FGAM cyclase). fGAM + ATP → ... A key regulatory step is the production of 5-phospho-α-D-ribosyl 1-pyrophosphate (PRPP) by ribose phosphate pyrophosphokinase, ... PRPP + L-Glutamine + H2O → PRA + L-Glutamate + PPi In the second step react PRA, glycine and ATP to create GAR, ADP, and ... CAIR + L-Aspartate + ATP → SAICAR + ADP + Pi The eight is catalyzed by adenylosuccinate lyase. SAICAR → AICAR + Fumarate The ...
*  List of EC numbers (EC 3)
ADP-ribosyl-(dinitrogen reductase) hydrolase EC 3.2.2.25: N-methyl nucleosidase EC 3.2.2.26: futalosine hydrolase EC 3.2.2.27: ... drimenol cyclase EC 3.1.7.8: tuberculosinol synthase EC 3.1.7.9: isotuberculosinol synthase EC 3.1.7.10: (13E)-labda-7,13-dien- ... ADP-dependent short-chain-acyl-CoA hydrolase EC 3.1.2.19: ADP-dependent medium-chain-acyl-CoA hydrolase EC 3.1.2.20: acyl-CoA ... Now EC 3.6.5.6, tubulin GTPase EC 3.6.1.52: diphosphoinositol-polyphosphate diphosphatase EC 3.6.1.53: Mn2+-dependent ADP- ...
CD38 (ADP Ribosyl Cyclase I) Antibody - Without BSA and Azide - Mouse Monoclonal Antibody [Clone AT2 ] IF, FC - Buy Now! |Abgent  CD38 (ADP Ribosyl Cyclase I) Antibody - Without BSA and Azide - Mouse Monoclonal Antibody [Clone AT2 ] IF, FC - Buy Now! |Abgent
CD38 (ADP Ribosyl Cyclase I) Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone AT2 ] validated in IF, FC ( ... ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 3.2.2.6, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'- ... AH12734: CD38 (ADP Ribosyl Cyclase 1) Antibody - With BSA and Azide. AH12735: CD38 (ADP Ribosyl Cyclase 1) Antibody - Without ... ADP Ribosyl Cyclase I) Antibody - Without BSA and Azide CD38 (ADP Ribosyl Cyclase I) Antibody - Without BSA and Azide. Mouse ...
more infohttp://www.abgent.com/products/AH12737-CD38-ADP-Ribosyl-Cyclase-I-Antibody-Without-BSA-and-Azide
EXBIO Antibodies Product Data Sheet  EXBIO Antibodies Product Data Sheet
CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase ... CD38 induces apoptosis of a murine pro-B leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD ... Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the ...
more infohttp://www.exbio.cz/pdf/data_sheet_new.py/CLO000000000000035/30/6/datasheet-PC-366-T100.html?format=html
EC 3.2.2.5  EC 3.2.2.5
... without associated ADP-ribosyl cyclase activities (unlike the metazoan enzyme EC 3.2.2.6, bifunctional ADP-ribosyl cyclase/ ... Reaction: NAD+ + H2O = ADP-D-ribose + nicotinamide. Glossary: ADP-D-ribose = adenosine 5′-(5-deoxy-D-ribofuranos-5-yl ... cyclic ADP-ribose hydrolase). The enzyme from Group A streptococci has been implicated in the pathogenesis of diseases such as ...
more infohttp://www.sbcs.qmul.ac.uk/iubmb/enzyme/EC3/2/2/5.html
ADP ribosyl Cyclase - Medical Dictionary online-medical-dictionary.org  ADP ribosyl Cyclase - Medical Dictionary online-medical-dictionary.org
ADP ribosyl Cyclase. A Membrane-bound or cytosolic enzyme that catalyzes the synthesis of Cyclic ADP-Ribose (cADPR) from ... and sometimes the synthesis of Cyclic ADP-Ribose 2' phosphate (2'-P-cADPR) from NADP. ... Nicotinamide Adenine Dinucleotide (NAD). This enzyme generally catalyzes the Hydrolysis of cADPR to ADP-Ribose, as well, ...
more infohttp://www.online-medical-dictionary.org/definitions-a/adp-ribosyl-cyclase.html
ADP-ribosyl cyclase 2 | definition of ADP-ribosyl cyclase 2 by Medical dictionary  ADP-ribosyl cyclase 2 | definition of ADP-ribosyl cyclase 2 by Medical dictionary
What is ADP-ribosyl cyclase 2? Meaning of ADP-ribosyl cyclase 2 medical term. What does ADP-ribosyl cyclase 2 mean? ... Looking for online definition of ADP-ribosyl cyclase 2 in the Medical Dictionary? ADP-ribosyl cyclase 2 explanation free. ... ADP-ribosyl cyclase 2 , definition of ADP-ribosyl cyclase 2 by Medical dictionary https://medical-dictionary.thefreedictionary. ... redirected from ADP-ribosyl cyclase 2) BST1. A gene on chromosome 4p15 that encodes bone marrow stromal cell antigen-1, a ...
more infohttps://medical-dictionary.thefreedictionary.com/ADP-ribosyl+cyclase+2
The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain. | Sigma...  The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain. | Sigma...
The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain.. [ ... Nicotinamide guanine dinucleotide sodium salt, phospodiesterase and ADP-ribosyl cyclase substrate C21H28N7O15P2 ... We propose that this novel mammalian ADP-ribosyl cyclase regulates the production of cADPR and therefore calcium levels within ... We show that Cd38-/- synaptosome preparations contain high ADP-ribosyl cyclase activities, which are more important in neonates ...
more infohttps://www.sigmaaldrich.com/catalog/papers/16411897
STILBENE DERIVATIVES FOR ADP-RIBOSYL CYCLASE INHIBITORS - Patent application  STILBENE DERIVATIVES FOR ADP-RIBOSYL CYCLASE INHIBITORS - Patent application
... in which pathogenesis ADPR-cyclase is involved. BACKGROUND ART [0003] ADP-ribosyl cyclase (ADPR-cyclase) is widely distributed ... 0002] The present disclosure relates to bisphenyl compounds that are useful for inhibit the ADP-ribosyl cyclase (ADPR-cyclase ... The present disclosure relates to bisphenyl compounds that are useful for inhibiting the ADP-ribosyl cyclase (ADPR-cyclase). ... Patent application title: STILBENE DERIVATIVES FOR ADP-RIBOSYL CYCLASE INHIBITORS. Inventors: Uh-Hyun Kim (Jeonbuk, KR) Ho ...
more infohttp://www.patentsencyclopedia.com/app/20110281826
A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and...  A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and...
... the ADP-ribosyl cyclases. Not all ADP-ribosyl cyclases have been identified, and how production of different messengers is ... Here, we report the cloning and characterization of a novel ADP-ribosyl cyclase (SpARC4) from the sea urchin, a key model ... Like several other members of the ADP-ribosyl cyclase superfamily, SpARC4 is a glycoprotein targeted to the plasma membrane via ... and suggest that different ADP-ribosyl cyclases are fine-tuned to produce specific calcium-mobilizing messengers. ...
more infohttps://www.semanticscholar.org/paper/A-single-residue-in-a-novel-ADP-ribosyl-cyclase-of-Ramakrishnan-Muller-Steffner/42af6685efa83e286820b56546ebfbe7705ebcb1
ELISA ADP-ribosyl cyclase 1,cADPr hydrolase 1,Cd38,Cyclic ADP-ribose hydrolase 1,I-19,Mouse,Mus musculus,NIM-R5 antigen  ELISA ADP-ribosyl cyclase 1,cADPr hydrolase 1,Cd38,Cyclic ADP-ribose hydrolase 1,I-19,Mouse,Mus musculus,NIM-R5 antigen
Cyclic ADP-ribose hydrolase 1,I-19,Mouse,Mus musculus,NIM-R5 antigen - Gentaur molecular products ... Product ELISA ADP-ribosyl cyclase 1,cADPr hydrolase 1,Cd38, ... ELISA ADP-ribosyl cyclase 1,cADPr hydrolase 1,Cd38,Cyclic ADP- ... ELISA ADP-ribosyl cyclase 1,cADPr hydrolase 1,Cd38,Cyclic ADP-ribose hydrolase 1,I-19,Mouse,Mus musculus,NIM-R5 antigen mus ... Product name : ELISA ADP-ribosyl cyclase 1,cADPr hydrolase 1,Cd38,Cyclic ADP-ribose hydrolase 1,I-19,Mouse,Mus musculus,NIM-R5 ...
more infohttps://www.antibody-antibodies.com/product3086918/eiaab-elisa-adp-ribosyl-cyclase-1-cadpr-hydrolase-1-cd38-cyclic-adp-ribose-hydrolase-1-i-19-mouse-mus-musculus-nim-r5-antigen.html
Cyclic adenosine 5-diphosphate ribose analogs without a southern ribose inhibit ADP-ribosyl cyclase-hydrolase CD38. -...  Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38. -...
Replacing the base N9-ribose with a butyl chain generates inhibitors of cADPR hydrolysis by the human ADP-ribosyl cyclase CD38 ... Replacing the base N9-ribose with a butyl chain generates inhibitors of cADPR hydrolysis by the human ADP-ribosyl cyclase CD38 ... Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38. ... ADP-ribosyl Cyclase 1, Catalytic Domain, Chemistry Techniques, Synthetic, Chromatography, High Pressure Liquid, Crystallography ...
more infohttps://pharm.ox.ac.uk/publications/677784
Adp-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor. a primary role for cyclic ADP-ribose in hypoxic...  Adp-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor. a primary role for cyclic ADP-ribose in hypoxic...
Because cyclic ADP-ribose (cADPR) regulates ryanodine receptors and is synthesized from beta-NAD(+), we investigated the ... ADP-ribosyl Cyclase, ADP-ribosyl Cyclase 1, Animals, Antigens, CD, Antigens, Differentiation, Hypertension, Pulmonary, Hypoxia ... Adp-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor. a primary role for cyclic ADP-ribose in hypoxic ... Adp-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor. a primary role for cyclic ADP-ribose in hypoxic ...
more infohttps://pharm.ox.ac.uk/publications/106282
Enzyme Explorer Assay Library | Sigma-Aldrich  Enzyme Explorer Assay Library | Sigma-Aldrich
ADP-Ribosylcyclase none. Agarase 3.2.1.81. Alanine Aminopeptidase 3.4.11.14. L-Alanine Dehydrogenase 1.4.1.1. ... Adenylate Cyclase 4.6.1.1. 5'-Adenylic Acid Deaminase 3.5.4.6. Adenylosuccinate Lyase 4.3.2.2. ...
more infohttps://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/learning-center/assay-library.html
Ryanodine receptor subtype 2 encodes Ca2+ oscillations activated by acetylcholine via the M2 muscarinic receptor/cADP-ribose...  Ryanodine receptor subtype 2 encodes Ca2+ oscillations activated by acetylcholine via the M2 muscarinic receptor/cADP-ribose...
ADP-ribosyl cyclase activity measurement. To evaluate the activity of ADP-ribosyl cyclase, we used the ability of the cyclase ... de Toledo, F. G., Cheng, J., Liang, M., Chini, E. N. and Dousa, T. P. (2000). ADP-Ribosyl cyclase in rat vascular smooth muscle ... ADP-ribosyl cyclase activity and cADPR-induced Ca2+ oscillations. As previously reported in biochemical studies on subcellular ... Both ADP-ribosyl cyclase inhibitors (ZnCl2 and the anti-CD38 antibody) and methoctramine (10 μM) inhibited the ACh-induced ...
more infohttp://jcs.biologists.org/content/118/10/2261
Frontiers | Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or...  Frontiers | Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or...
... and ADP in mouse oxytocinergic neurons. As these -NAD+ metabolites activate warm-sensitive TRPM2 cation channels, when the ... and ADP in mouse oxytocinergic neurons. As these -NAD+ metabolites activate warm-sensitive TRPM2 cation channels, when the ... is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. Previously, we showed that ... is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. Previously, we showed that ...
more infohttps://www.frontiersin.org/articles/10.3389/fnins.2016.00304/full
Recombinant Human CD38 protein (ab114253) | Abcam  Recombinant Human CD38 protein (ab114253) | Abcam
ADP ribosyl cyclase 1. *ADP ribosyl cyclase/cyclic ADP-ribose hydrolase. *ADP-ribosyl cyclase 1 ... Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. ... ADP ribosyl cyclase. * ...
more infohttp://www.abcam.com/recombinant-human-cd38-protein-ab114253.html
Biomarkers - Olink	  Biomarkers - Olink
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1). Links to databases. *Uniprot Q10588 ... Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger ...
more infohttps://www.olink.com/products/development-panel/biomarkers/?biomarkerId=1436
Anti-CD38 antibody (FITC) [90] | Abcam  Anti-CD38 antibody (FITC) [90] | Abcam
ADP ribosyl cyclase 1 antibody. *ADP ribosyl cyclase antibody. *ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody ... Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. ...
more infohttp://www.abcam.com/cd38-antibody-90-fitc-ab24978.html
Bone marrow stromal cell antigen 1/CD157 Antibody (AF4710): Novus Biologicals  Bone marrow stromal cell antigen 1/CD157 Antibody (AF4710): Novus Biologicals
CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities (2). It ...
more infohttps://www.novusbio.com/products/bone-marrow-stromal-cell-antigen-1-cd157-antibody_af4710
Cluster of Differentiation  Cluster of Differentiation
CD157 has ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities CELLULAR FUNCTION OF CD157 *Supporting the growth of a ... CD157-->ADP-ribosyl cyclase *CD157-->ectoenzyme MOLECULAR STRUCTURE OF CD157 *Single chain GPI-anchored molecule (318 amino ... ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1. FEBS Lett. 1994 356:244 PubMed 4. ... Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase. Biochem. Biophys. Res. Commun. ...
more infohttp://sciencegateway.org/resources/prow/guide/1340226072_g.htm
Cd38 - Uncharacterized protein - Mus musculus (Mouse) - Cd38 gene & protein  Cd38 - Uncharacterized protein - Mus musculus (Mouse) - Cd38 gene & protein
Cluster: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. 7. Full view ... Cluster: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. 98. Full view ...
more infohttp://www.uniprot.org/uniprot/Q3UCS6
Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma | SpringerLink  Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma | SpringerLink
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology. Physiol Rev. 2008;88(3):841-86. ... A single protein immunologically identified as CD38 displays NAD1 glycohydrolase, ADP-ribosylcyclase and cyclic ADP- ... Innate immunity is regulated by CD38, an ecto-enzyme with ADP-ribosyl cyclaseactivity. Microbes Infect. 2003;5(1):49-58. ... Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in ...
more infohttps://link.springer.com/article/10.1007%2Fs40265-016-0573-4
KAKEN - Research Projects | ATP合成酵素の高次構造 (KAKENHI-PROJECT-04266104)  KAKEN - Research Projects | ATP合成酵素の高次構造 (KAKENHI-PROJECT-04266104)
ADP-ribosyl cyclase/Cyclic ADP-ribose hydrolase)to chromosome 4p15.' Cytogenet.Cell Genet.69. 38-39 (1995). *. Related Report. ... Cloning and characterization of cDNA encoding rat ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase(homologue to human CD38)from ... Publications] Y.Hirata,Y.Ohsugi,H.Okamoto,T.Kaisho,T.Hirano,et all.: 'ADP ribosyl cyclase activity of a novel bone marrow ... The structure of the Aplysia kurodai gene encoding ADP-ribosyl cyclase,a secondmessenger enzyme.' Gene.(in press).. *. Related ...
more infohttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04266104/
Mapping of the catalytic and epitopic sites of human CD38/NAD+ glycohydrolase to a functional domain in the carboxyl terminus. ...  Mapping of the catalytic and epitopic sites of human CD38/NAD+ glycohydrolase to a functional domain in the carboxyl terminus. ...
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology.. *Fabio Malavasi, Silvia ... Molecular characterization of novel ADP-ribosyl cyclases from the sea urchin. *Latha Ramakrishnan ... Characterization and phylogenetic epitope mapping of CD38 ADPR cyclase in the cynomolgus macaque. *Enza Ferrero, Monia Orciani ...
more infohttps://www.semanticscholar.org/paper/Mapping-of-the-catalytic-and-epitopic-sites-of-to-a-Hoshino-Kukimoto/b6e55748c7b1f568e03fccfccf3d1978258bdf46
  • With 2-fluoro-NAD+ as substrate, A. californica ADP-ribosyl cyclase exhibited exclusively a NAD+ glycohydrolase activity, catalyzing its hydrolytic transformation into 2-fluoro-ADP-ribose, albeit at a rate ca. 100-fold slower than for the cyclization of NAD+ and also, in the presence of methanol, into its methanolysis product beta-1' '-O-methyl 2-fluoro-ADP-ribose with a preference for methanolysis over hydrolysis of ca. 100:1. (ox.ac.uk)
  • Stimulation of ADP-ribosyl cyclase activity by acetylcholine was evaluated in permeabilized cells by measuring the production of cyclic guanosine diphosphoribose (a fluorescent compound), which resulted from the cyclization of nicotinamide guanine dinucleotide. (biologists.org)
  • CAIR + L-Aspartate + ATP → SAICAR + ADP + Pi The eight is catalyzed by adenylosuccinate lyase. (wikipedia.org)
  • 11. The method of claim 10, wherein the compound of Formula I, wherein 4,4'-dihydroxyazobenzene is kidney specific ADPR-cyclase inhibitor. (patentsencyclopedia.com)
  • 13. The method of claim 10, wherein the compound of Formula I is 2,2'-dihydroxyazobenzene for inhibiting heart specific ADPR-cyclase. (patentsencyclopedia.com)