Helicobacter pylori: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.Mice, SCID: Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.Gastritis: Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Mice, Inbred C57BLApoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Antigens, CD8: Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.Trophoblasts: Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).Adoptive Transfer: Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Th1 Cells: Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.Th2 Cells: Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.Fetal Resorption: The disintegration and assimilation of the dead FETUS in the UTERUS at any stage after the completion of organogenesis which, in humans, is after the 9th week of GESTATION. It does not include embryo resorption (see EMBRYO LOSS).T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Killer Cells, Natural: Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.Dendritic Cells: Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).Mice, Inbred C57BLAntigens, CD56: The 140 kDa isoform of NCAM (neural cell adhesion molecule) containing a transmembrane domain and short cytoplasmic tail. It is expressed by all lymphocytes mediating non-MHC restricted cytotoxicity and is present on some neural tissues and tumors.Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Lymphocyte Subsets: A classification of lymphocytes based on structurally or functionally different populations of cells.Receptors, CXCR5: CXCR receptors isolated initially from BURKITT LYMPHOMA cells. CXCR5 receptors are expressed on mature, recirculating B-LYMPHOCYTES and are specific for CHEMOKINE CXCL13.T-Lymphocytes, Helper-Inducer: Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions.Immunotherapy, Adoptive: Form of adoptive transfer where cells with antitumor activity are transferred to the tumor-bearing host in order to mediate tumor regression. The lymphoid cells commonly used are lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL). This is usually considered a form of passive immunotherapy. (From DeVita, et al., Cancer, 1993, pp.305-7, 314)Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Immunotherapy: Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Pelger-Huet Anomaly: Autosomal dominant anomaly characterized by abnormal ovoid shape GRANULOCYTE nuclei and their clumping chromatin. Mutations in the LAMIN B receptor gene that results in reduced protein levels are associated with the disorder. Heterozygote individuals are healthy with normal granulocyte function while homozygote individuals occasionally have skeletal anomalies, developmental delay, and seizures.Hysteroscopes: Endoscopes for examining the interior of the uterus.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Mice, Inbred C57BLAdoptive Transfer: Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).Inflammatory Bowel Diseases: Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.Dendritic Cells: Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).Fas Ligand Protein: A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.Colitis, Ulcerative: Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.Adoptive Transfer: Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Ileitis: Inflammation of any segment of the ILEUM and the ILEOCECAL VALVE.Transplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Hematologic Neoplasms: Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.Capillary Leak Syndrome: A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE.Syndrome: A characteristic symptom complex.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Adoptive Transfer: Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).Gastroenterology: A subspecialty of internal medicine concerned with the study of the physiology and diseases of the digestive system and related structures (esophagus, liver, gallbladder, and pancreas).Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)T-Lymphocytes, Regulatory: CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.Research Personnel: Those individuals engaged in research.Adoptive Transfer: Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).Research Support as Topic: Financial support of research activities.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Forkhead Transcription Factors: A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.Interleukin-2 Receptor alpha Subunit: A low affinity interleukin-2 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN to form a high affinity receptor for INTERLEUKIN-2.Research Design: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
(1/4012) Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor.

Collagen type II-induced arthritis (CIA) in DBA/1 mice can be passively transferred to SCID mice with spleen B- and T-lymphocytes. In the present study, we show that infection ex vivo of splenocytes from arthritic DBA/1 mice with a retroviral vector, containing cDNA for the soluble form of human p75 receptor of tumour necrosis factor (TNF-R) before transfer, prevents the development of arthritis, bone erosion and joint inflammation in the SCID recipients. Assessment of IgG subclass levels and studies of synovial histology suggest that down-regulating the effector functions of T helper-type 1 (Th1) cells may, at least in part, explain the inhibition of arthritis in the SCID recipients. In contrast, the transfer of splenocytes infected with mouse TNF-alpha gene construct resulted in exacerbated arthritis and enhancement of IgG2a antibody levels. Intriguingly, infection of splenocytes from arthritic DBA/1 mice with a construct for mouse IL-10 had no modulating effect on the transfer of arthritis. The data suggest that manipulation of the immune system with cytokines, or cytokine inhibitors using gene transfer protocols can be an effective approach to ameliorate arthritis.  (+info)

(2/4012) Thymic selection by a single MHC/peptide ligand: autoreactive T cells are low-affinity cells.

In H2-M- mice, the presence of a single peptide, CLIP, bound to MHC class II molecules generates a diverse repertoire of CD4+ cells. In these mice, typical self-peptides are not bound to class II molecules, with the result that a very high proportion of H2-M- CD4+ cells are responsive to the various peptides displayed on normal MHC-compatible APC. We show here, however, that such "self" reactivity is controlled by low-affinity CD4+ cells. These cells give spectacularly high proliferative responses but are virtually unreactive in certain other assays, e.g., skin graft rejection; responses to MHC alloantigens, by contrast, are intense in all assays. Possible explanations for why thymic selection directed to a single peptide curtails self specificity without affecting alloreactivity are discussed.  (+info)

(3/4012) Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome.

Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL) probably play the major role in controlling HIV replication. However, the value of adoptive transfer of HIV-specific CTL expanded in vitro to HIV+ patients has been limited: this contrasts with the success of CTL therapy in treating or preventing Epstein-Barr virus and cytomegalovirus disease after bone marrow transplantation (BMT). We investigated the fate of expanded HIV-specific CTL clones in vivo following adoptive transfer to a patient with acquired immunodeficiency syndrome (AIDS). Two autologous CTL clones specific for HIV Gag and Pol were expanded to large numbers (>10(9)) in vitro and infused into an HIV-infected patient whose viral load was rising despite antiretroviral therapy. The fate of one clone was monitored by staining peripheral blood mononuclear cells (PBMCs) with T-cell receptor-specific tetrameric major histocompatibility complex (MHC)-peptide complexes. Although the CTL transfer was well tolerated, there were no significant changes in CD4 and CD8 lymphocyte counts and virus load. By tracking an infused clone using soluble MHC-peptide complexes, we show that cells bearing the Gag-specific T-cell receptors were rapidly eliminated within hours of infusion through apoptosis. Thus, the failure of adoptively transferred HIV-specific CTL to reduce virus load in AIDS may be due to rapid apoptosis of the infused cells, triggered by a number of potential mechanisms. Further trials of adoptive transfer of CTL should take into account the susceptibility of infused cells to in vivo apoptosis.  (+info)

(4/4012) Chlamydia infections and heart disease linked through antigenic mimicry.

Chlamydia infections are epidemiologically linked to human heart disease. A peptide from the murine heart muscle-specific alpha myosin heavy chain that has sequence homology to the 60-kilodalton cysteine-rich outer membrane proteins of Chlamydia pneumoniae, C. psittaci, and C. trachomatis was shown to induce autoimmune inflammatory heart disease in mice. Injection of the homologous Chlamydia peptides into mice also induced perivascular inflammation, fibrotic changes, and blood vessel occlusion in the heart, as well as triggering T and B cell reactivity to the homologous endogenous heart muscle-specific peptide. Chlamydia DNA functioned as an adjuvant in the triggering of peptide-induced inflammatory heart disease. Infection with C. trachomatis led to the production of autoantibodies to heart muscle-specific epitopes. Thus, Chlamydia-mediated heart disease is induced by antigenic mimicry of a heart muscle-specific protein.  (+info)

(5/4012) Adoptive transfer of genetically modified macrophages elucidated TGF-beta-mediated 'self-defence' of the glomerulus against local action of macrophages.

TGF-beta has several anti-inflammatory properties which may be relevant to prevention of or recovery from acute glomerular inflammation. Using genetically modified mesangial cells and a technique for in vivo macrophage transfer, this article provides evidence for TGF-beta-mediated 'self-defence' of the glomerulus against macrophages. Rat mesangial cells stably transfected with TGF-beta1 showed a blunted response to the macrophage-derived, proinflammatory cytokine IL-1beta. In contrast, mesangial cells expressing the dominant-interfering TGF-beta receptor showed an enhanced response to IL-1. Similarly, externally added TGF-beta1 inhibited the cytokine response of normal glomeruli, and isolated nephritic glomeruli producing active TGF-beta1 showed a depressed response to IL-1beta, compared to normal glomeruli. Consistent with these in vitro results, in vivo transfer of activated macrophages revealed that the TGF-beta-producing glomeruli are insensitive to the effector action of macrophages. These results indicate that TGF-beta1 functions as an endogenous 'defender' that counteracts local action of activated macrophages in the glomerulus.  (+info)

(6/4012) Efficient IgG-mediated suppression of primary antibody responses in Fcgamma receptor-deficient mice.

IgG antibodies can suppress more than 99% of the antibody response against the antigen to which they bind. This is used clinically to prevent rhesus-negative (Rh-) women from becoming immunized against Rh+ erythrocytes from their fetuses. The suppressive mechanism is poorly understood, but it has been proposed that IgG/erythrocyte complexes bind to the inhibitory Fc receptor for IgG (FcgammaRIIB) on the B cell surface, thereby triggering negative signals that turn off the B cell. We show that IgG induces the same degree of suppression of the response to sheep erythrocytes in animals lacking the known IgG-binding receptors FcgammaRIIB, FcgammaRI + III, FcgammaRI + IIB + III, and FcRn (the neonatal Fc receptor) as in wild-type animals. Reinvestigation of the ability of F(ab')2 fragments to suppress antibody responses demonstrated that they were nearly as efficient as intact IgG. In addition, monoclonal IgE also was shown to be suppressive. These findings suggest that IgG inhibits antibody responses through Fc-independent mechanisms, most likely by masking of antigenic epitopes, thereby preventing B cells from binding and responding to antigen. In agreement with this, we show that T cell priming is not abolished by passively administered IgG. The results have implications for the understanding of in vivo regulation of antibody responses and Rh prophylaxis.  (+info)

(7/4012) Tolerance to antigen-presenting cell-depleted islet allografts is CD4 T cell dependent.

Pretreatment of pancreatic islets in 95% oxygen culture depletes graft-associated APCs and leads to indefinite allograft acceptance in immunocompetent recipients. As such, the APC-depleted allograft represents a model of peripheral alloantigen presentation in the absence of donor-derived costimulation. Over time, a state of donor-specific tolerance develops in which recipients are resistant to donor APC-induced graft rejection. Thus, persistence of the graft is sufficient to induce tolerance independent of other immune interventions. Donor-specific tolerance could be adoptively transferred to immune-deficient SCID recipient mice transplanted with fresh immunogenic islet allografts, indicating that the original recipient was not simply "ignorant" of donor antigens. Interestingly, despite the fact that the original islet allograft presented only MHC class I alloantigens, CD8+ T cells obtained from tolerant animals readily collaborated with naive CD4+ T cells to reject donor-type islet grafts. Conversely, tolerant CD4+ T cells failed to collaborate effectively with naive CD8+ T cells for the rejection of donor-type grafts. In conclusion, the MHC class I+, II- islet allograft paradoxically leads to a change in the donor-reactive CD4 T cell subset and not in the CD8 subset. We hypothesize that the tolerant state is not due to direct class I alloantigen presentation to CD8 T cells but, rather, occurs via the indirect pathway of donor Ag presentation to CD4 T cells in the context of host MHC class II molecules.  (+info)

(8/4012) Mucosal immunity to influenza without IgA: an IgA knockout mouse model.

IgA knockout mice (IgA-/-) were generated by gene targeting and were used to determine the role of IgA in protection against mucosal infection by influenza and the value of immunization for preferential induction of secretory IgA. Aerosol challenge of naive IgA-/- mice and their wild-type IgA+/+ littermates with sublethal and lethal doses of influenza virus resulted in similar levels of pulmonary virus infection and mortality. Intranasal and i.p. immunization with influenza vaccine plus cholera toxin/cholera toxin B induced significant mucosal and serum influenza hemagglutinin-specific IgA Abs in IgA+/+ (but not IgA-/-) mice as well as IgG and IgM Abs in both IgA-/- and IgA+/+ mice; both exhibited similar levels of pulmonary and nasal virus replication and mortality following a lethal influenza virus challenge. Monoclonal anti-hemagglutinin IgG1, IgG2a, IgM, and polymeric IgA Abs were equally effective in preventing influenza virus infection in IgA-/- mice. These results indicate that IgA is not required for prevention of influenza virus infection and disease. Indeed, while mucosal immunization for selective induction of IgA against influenza may constitute a useful approach for control of influenza and other respiratory viral infections, strategies that stimulate other Igs in addition may be more desirable.  (+info)

*  Adoptive cell transfer
... (ACT) is the transfer of cells into a patient. The cells may have originated from the patient or from ... Adoptive Transfer at the US National Library of Medicine Medical Subject Headings (MeSH) Adoptive Immunotherapy at the US ... The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant ... Marcus A, Eshhar Z (2011). "Allogeneic adoptive cell transfer therapy as a potent universal treatment for cancer". Oncotarget. ...
*  Adoptive immunity
adoptive transfer adoptive immunization adoptive immunotherapy Adoptive cell therapy adoptive tolerance Rosenberg, SA; Restifo ... 2003). "Adoptive transfer." [Dictionary for Keywords in Molecular Biology and Immunology], 2nd ed. Tokyo: Igakushoin, Ltd., p. ... Transfer of cells are made between allogeneic hosts but the new host is irradiated for preventing rejection or GVHD. Transfer ... Transferred components are immune cells and autologous as above. Transfer of immune cells is made between different individuals ...
*  Cancer immunotherapy
Adoptive T-cell therapy is a form of passive immunization by the transfusion of T-cells (adoptive cell transfer). They are ... Another approach is adoptive transfer of haploidentical γδ T cells or NK cells from a healthy donor. The major advantage of ... "Successful adoptive transfer and in vivo expansion of haploidentical γδ T cells". Journal of Translational Medicine. 12: 45. ... The first 2 adoptive T-cell therapies, tisagenlecleucel and axicabtagene ciloleucel, were approved by the FDA in 2017. ...
*  Experiments in immunology
For example, adoptive transfer is used to study the effects of lymphocytes in the absence of other lymphoid cells. Ionizing ... 2009). "Adoptive transfer of virus-specific and tumor-specific T cell immunity." Current Opinion in Immunology 21(2): 224-232. ... The body is thus prepared for restoration of immune function by adoptive transfer of new lymphocytes. Another method is ... hematopoietic stem-cell transfer, used for studying lymphocyte development. Hematopoietic cells are killed by ionizing ...
*  MHC multimer
2005). "Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide ... "Multimer technologies for detection and adoptive transfer of antigen-specific T cells". Cancer Immunol Immunother. 2010 (59): ... Uhlin; Okas M; Gertow J; Uzunel M; Brismar TB; Mattsson J. (2009). "A novel haplo-identical adoptive CTL therapy as a treatment ... 2009 a special dispensation was granted for a team to use them for isolating EBV-specific T cells for mother-daughter transfer ...
*  Mikael Pittet
"In vivo imaging of T cell delivery to tumors after adoptive transfer therapy". Proc Natl Acad Sci U S A. 104: 12457-12461. doi: ...
*  Intrastructural help
and was also verified for HIV in the mouse model by adoptive transfer experiments. Non-human primate experiments also indicate ... Thus, the approach has also transferred well for the treatment of hepatitis B and HIV. One of the approaches for a protective ...
*  IBA Lifesciences
"Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer". Nat Med. 8 (6 ...
*  Autologous immune enhancement therapy
May 1995). "Prolonged disease-free period in patients with advanced epithelial ovarian cancer after adoptive transfer of tumor- ... Adoptive Immuno cell therapy of cancer was first introduced by Steven Rosenberg and his colleagues of National Institute of ... September 2000). "Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial ... July 2003). "Tumor-localization by adoptively transferred, interleukin-2-activated NK cells leads to destruction of well- ...
*  Immunotherapy
Adoptive cell transfer in vitro cultivates autologous, extracted T cells for later transfusion. The T cells may already target ... Rosenberg SA, Restifo NP, Yang JC, Morgan RA, Dudley ME (April 2008). "Adoptive cell transfer: a clinical path to effective ... Adoptive cell transfer has been tested on lung and other cancers. Dendritic cells can be stimulated to activate a cytotoxic ... "Efficacy of adoptive cell transfer of tumor-infiltrating lymphocytes after lymphopenia induction for metastatic melanoma". J. ...
*  Marcel R.M. van den Brink
"Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation ... and adoptive cell therapy with precursor T cells and b) novel insights in the pathophysiology of graft-versus-host disease ( ...
*  Chimeric antigen receptor
Although adoptive transfer of CAR-modified T-cells is a unique and promising cancer therapeutic, there are significant safety ... A CAR therapy for cancer, using a technique called adoptive cell transfer, has been approved by the US Food and Drug ... Adoptive transfer of T cells expressing chimeric antigen receptors is a promising anti-cancer therapeutic as CAR-modified T ... Adoption of suicide gene therapy to the clinical application of CAR-modified T cell adoptive cell transfer has potential to ...
*  Tumor-infiltrating lymphocytes
The use of TILs as an adoptive cell transfer therapy to treat cancer was pioneered by Dr. Steven Rosenberg at the National ... "Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in ... "Efficacy of adoptive cell transfer of tumor-infiltrating lymphocytes after lymphopenia induction for metastatic melanoma". ... Lion Biotechnologies is developing adoptive cell transfer with TILs as a cancer therapy. Several centres are currently working ...
*  ALECSAT
Research on adoptive transfer in melanoma patients laid the groundwork for companies focusing on adoptive transfer research in ... In a study run at the University de la Sante, the adoptive transfer of cloned T cells in "in vitro immunization" caused ... "Adoptive transfer of tumor-reactive Melan-A-specific CTL clones in melanoma patients is followed by increased frequencies of ... The latter method is utilized for ALECSAT to treat cancer by adoptive T-cell immunotherapy. Refer to the adjacent diagram for a ...
*  Artificial antigen presenting cells
Activated and stimulated T cells can be studied in this biomimetic contex and used for adoptive transfer as an immunotherapy. ... These T cells can be then re-infused or adoptively transferred into the patient for effective cancer therapy. This technology ...
*  Cancer
Approaches include antibodies, checkpoint therapy and adoptive cell transfer. Laser therapy uses high-intensity light to treat ...
*  Freund's adjuvant
"Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice ...
*  Immunity (medical)
Passive or "adoptive transfer" of cell-mediated immunity, is conferred by the transfer of "sensitized" or activated T-cells ... Passive immunity is also provided through the transfer of IgA antibodies found in breast milk that are transferred to the gut ... This type of transfer differs from a bone marrow transplant, in which (undifferentiated) hematopoietic stem cells are ... In unmatched donors this type of transfer carries severe risks of graft versus host disease. It has, however, been used to ...
*  Streptamer
... and adoptive transfer of defined antigen specific T cell populations. This may now be realized as very effective therapeutic ... Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer. Nature ... Second, the amount of d-biotin that might be transferred with Streptamer isolated T-cells are far lower than d-biotin ... expanded T cell lines or clones can be easily purified from contaminating cells or cell debris before transfer to clinical ...
*  Tumor antigens recognized by T lymphocytes
Adoptive transfer of TILs can increase the survival of melanoma patients when it is used as an adjuvant therapy, i.e. after a ... Adoptive transfer involves either collecting from patients intratumoral or blood T cells, stimulate them in vitro against ... Adoptive TIL transfer in the adjuvant setting for melanoma: long-term patient survival ". Journal of Immunology Research. 2014 ... but also the adoptive transfer of T cells that recognize these antigens. Finally, antibodies that increase the general activity ...
*  Epstein-Barr virus nuclear antigen 1
Adoptive ex vivo transfer of EBNA-1-specific T cells is a feasible and well-tolerated therapeutic option, however for optimal ... "Adoptive transfer of epstein-barr virus (EBV) nuclear antigen 1-specific t cells as treatment for EBV reactivation and ...
*  Nicholas P. Restifo
The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant ... adoptive cell transfer for the treatment of cancer, and the biology of self/tumor-reactive T cells, with an emphasis on memory ... and his therapeutic approaches employ adoptive T cell transfer, gene modification and cellular reprogramming. Basic aspects of ... Thus Cish represents a new class of T-cell intrinsic immunologic checkpoints with the potential to radically enhance adoptive ...
*  CISH
The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant ...
*  Nicholas Chiorazzi
A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease" Blood 117 ...
*  List of MeSH codes (E02)
... adoptive transfer MeSH E02.095.520.400.330.050.400 --- immunotherapy, adoptive MeSH E02.095.520.400.470 --- immunization ... patient transfer MeSH E02.760.415.280 --- deinstitutionalization MeSH E02.760.611.470 --- home nursing MeSH E02.760.611.470.610 ... embryo transfer MeSH E02.875.800.750 --- fertilization in vitro MeSH E02.875.800.750.700 --- sperm injections, intracytoplasmic ... zygote intrafallopian transfer MeSH E02.880.690.490 --- hyperbaric oxygenation MeSH E02.880.820.508 --- high-frequency ...
*  Ma Shaohong
... while Emperor Zhuangzong's adoptive brother Li Siyuan had recently launched a successful surprise attack against Later Liang's ... and therefore tried to resign the chief of staff post and have it transferred to Li Shaohong, but Emperor Zhuangzong did not ...
Angiotensin Receptors - PI3K Signaling in B and T Lymphocytes  Angiotensin Receptors - PI3K Signaling in B and T Lymphocytes
Furthermore, adoptive transfer of CD4+ T cells from MRL/mice into nonautoimmune anti-snRNP B-cell receptor (BCR) transgenic ... Furthermore, autoantibodies were enough to induce disease in nonautoimmune mice pursuing adoptive transfer of antibodies in the ...
more infohttp://health-e-nc.org/category/angiotensin-receptors/
Patients with the autoimmune disease systemic lupus erythematosus (SLE) develop pathogenic - PI3K Signaling in B and T...  Patients with the autoimmune disease systemic lupus erythematosus (SLE) develop pathogenic - PI3K Signaling in B and T...
Furthermore, adoptive transfer of CD4+ T cells from MRL/mice into nonautoimmune anti-snRNP B-cell receptor (BCR) transgenic ... Furthermore, autoantibodies were enough to induce disease in nonautoimmune mice pursuing adoptive transfer of antibodies in the ...
more infohttp://health-e-nc.org/2017/06/15/patients-with-the-autoimmune-disease-systemic-lupus-erythematosus-sle-develop-pathogenic/
GI-4000 With Adoptive Transfer in Pancreatic Cancer  GI-4000 With Adoptive Transfer in Pancreatic Cancer
vaccine with or without adoptive T cell transfer in subjects with locally advanced. pancreatic cancer undergoing chemotherapy, ... An Inactivated Recombinant Saccharomyces Cerevisiae Expressing Mutant Ras Protein Combined With Adoptive Transfer And ... An Inactivated Recombinant Saccharomyces Cerevisiae Expressing Mutant Ras Protein Combined With Adoptive Transfer And ... T cell transfer). All subjects will undergo apheresis of mononuclear cells immediately. before receiving four cycles of ...
more infohttp://www.knowcancer.com/cancer-trials/NCT00837135/
Adoptive Transfer of Splenocytes in SCID Mice Implicates CD4+ T C...: Ingenta Connect  Adoptive Transfer of Splenocytes in SCID Mice Implicates CD4+ T C...: Ingenta Connect
Adoptive Transfer of Splenocytes in SCID Mice Implicates CD4+ T Cells in Apoptosis and Epithelial Proliferation Associated with ... Recipient mice differed, however, according to the source of the transferred CD4+ cells. The CD4+ cell scores for recipients of ... In contrast, gastric mucosal CD4+ cell scores did not become significantly high until two weeks after transfer (postinoculation ...
more infohttp://www.ingentaconnect.com/content/aalas/cm/2003/00000053/00000005/art00006
Adoptive Transfer of Haploidentical Natural Killer Cells and IL-2 - Full Text View - ClinicalTrials.gov  Adoptive Transfer of Haploidentical Natural Killer Cells and IL-2 - Full Text View - ClinicalTrials.gov
Adoptive Transfer of Haploidentical Natural Killer Cells and IL-2. The safety and scientific validity of this study is the ... Adoptive Transfer of Haploidentical Natural Killer Cells and IL-2 in Human Immunodeficiency Virus (HIV). ...
more infohttps://clinicaltrials.gov/ct2/show/NCT03346499
Adoptive transfer | Article about adoptive transfer by The Free Dictionary  Adoptive transfer | Article about adoptive transfer by The Free Dictionary
The transfer of immunologically competent white blood cells or their precursors into the host Explanation of adoptive transfer ... Looking for adoptive transfer? Find out information about adoptive transfer. ... adoptive immunotherapy. (redirected from adoptive transfer). Also found in: Dictionary, Medical.. Related to adoptive transfer ... Adoptive transfer , Article about adoptive transfer by The Free Dictionary https://encyclopedia2.thefreedictionary.com/adoptive ...
more infohttps://encyclopedia2.thefreedictionary.com/adoptive+transfer
Adoptive transfer of antigen-specific CD4+ T cells in the treatment of metastatic melanoma  Adoptive transfer of antigen-specific CD4+ T cells in the treatment of metastatic melanoma
... ... The successful adoptive transfer of antigen-specific CD4+ cells to a patient with metastatic melanoma is not only an important ... Clinical investigations of adoptive therapy in solid tumors have primarily focused on CD8+ cells. A study by Hunder et al. is ... This report demonstrates an impressive persistence of adoptively transferred cells together with durability of clinical ...
more infohttps://insights.ovid.com/ncpo/200812000/01223060-200812000-00014
Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma.  -...  Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma. -...
Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma.. Park ... This first-in-humans pilot study sets the stage for clinical trials employing adoptive transfer in the context of minimal ... and expansion to numbers sufficient for adoptive transfer. In total, 12 infusions (nine at 10(8) cells/m(2), three at 10(9) ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/17299405?dopt=Abstract
Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating...  Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating...
Adoptive cell transfer can mediate durable complete regressions in 24% of patients with metastatic melanoma, with median ... Adoptive cell transfer, the infusion of large numbers of activated autologous lymphocytes, can mediate objective tumor ... Here, we evaluated the importance of adding TBI to the adoptive transfer of tumor-infiltrating lymphocytes (TIL) in a ... Mean hematopoietic cell counts were transiently depressed in patients who received adoptive cell transfer, with a slightly ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/27217459
Adoptive transfer of normal Treg cells into BA mice sup | Open-i  Adoptive transfer of normal Treg cells into BA mice sup | Open-i
Adoptive transfer of normal Treg cells into BA mice suppresses RRV-induced generation of Th17 cells.Saline or RRV was injected ... pone.0136214.g004: Adoptive transfer of normal Treg cells into BA mice suppresses RRV-induced generation of Th17 cells.Saline ... pone.0136214.g004: Adoptive transfer of normal Treg cells into BA mice suppresses RRV-induced generation of Th17 cells.Saline ... were intraperitoneally transferred on day 5 of life. In vitro experiments also showed that Treg cells from mice with BA had a ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC4556529_pone.0136214.g004&req=4
Adoptive transfer of Th effector cells leads to AAD. BA | Open-i  Adoptive transfer of Th effector cells leads to AAD. BA | Open-i
Adoptive transfer of Th effector cells leads to AAD. BALB/c mice were injected with 2 × 106 cells followed by daily aerosolized ... Figure 1: Adoptive transfer of Th effector cells leads to AAD. BALB/c mice were injected with 2 × 106 cells followed by daily ... Figure 1: Adoptive transfer of Th effector cells leads to AAD. BALB/c mice were injected with 2 × 106 cells followed by daily ... after transfer of either Th1 or Th2 cells. (A, iii) Representative sections from mice transferred with Th1 cells (a and c) or ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2195756_JEM991003.f1c&req=4
ES cells have only a limited lymphopoietic potential after adoptive transfer into mouse recipients | Development  ES cells have only a limited lymphopoietic potential after adoptive transfer into mouse recipients | Development
ES cells have only a limited lymphopoietic potential after adoptive transfer into mouse recipients ... ES cells have only a limited lymphopoietic potential after adoptive transfer into mouse recipients ... ES cells have only a limited lymphopoietic potential after adoptive transfer into mouse recipients ... ES cells have only a limited lymphopoietic potential after adoptive transfer into mouse recipients ...
more infohttp://dev.biologists.org/content/118/4/1343
Adoptive Transfer of Paternal Antigen-Hyporesponsive T Cells Facilitates a Th2 Bias in Peripheral Lymphocytes and at Materno...  Adoptive Transfer of Paternal Antigen-Hyporesponsive T Cells Facilitates a Th2 Bias in Peripheral Lymphocytes and at Materno...
Jin, L.-P., Zhou, Y.-H., Zhu, X.-Y., Wang, M.-Y. and Li, D.-J. (2006), Adoptive Transfer of Paternal Antigen-Hyporesponsive T ... Adoptive Transfer of Paternal Antigen-Hyporesponsive T Cells Facilitates a Th2 Bias in Peripheral Lymphocytes and at Materno- ...
more infohttp://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2006.00425.x/references?globalMessage=0
Cutting Edge: Induction of Inflammatory Disease by Adoptive Transfer of an Atypical NK Cell Subset | The Journal of Immunology  Cutting Edge: Induction of Inflammatory Disease by Adoptive Transfer of an Atypical NK Cell Subset | The Journal of Immunology
Cutting Edge: Induction of Inflammatory Disease by Adoptive Transfer of an Atypical NK Cell Subset. Elisaveta Voynova, Chen- ... Cutting Edge: Induction of Inflammatory Disease by Adoptive Transfer of an Atypical NK Cell Subset ... Cutting Edge: Induction of Inflammatory Disease by Adoptive Transfer of an Atypical NK Cell Subset ... Cutting Edge: Induction of Inflammatory Disease by Adoptive Transfer of an Atypical NK Cell Subset ...
more infohttp://www.jimmunol.org/content/early/2015/06/23/jimmunol.1500540
Adoptive Transfer of Specific Melanoma Antigens CD8+ T Cells in Metastatic Melanoma Patients: a Phase I/II Study - Full Text...  Adoptive Transfer of Specific Melanoma Antigens CD8+ T Cells in Metastatic Melanoma Patients: a Phase I/II Study - Full Text...
Adoptive Transfer of Specific Melanoma Antigens CD8+ T Cells in Metastatic Melanoma Patients: a Phase I/II Study (MelSort). The ... Adoptive Transfer of CD8+ T Cells, Sorted With HLA-peptide Multimers and Specific for Melan-A and MELOE-1 Melanoma Antigens, to ... This study evaluates the safety as well as the potential clinical efficacy of an adoptive transfer of CD8+ T cells, sorted with ...
more infohttps://clinicaltrials.gov/ct2/show/NCT02424916?term=melanoma&rank=19
Adoptive Transfer of Specific Melanoma Antigens CD8+ T Cells in Metastatic Melanoma Patients: a Phase I/II Study - Full Text...  Adoptive Transfer of Specific Melanoma Antigens CD8+ T Cells in Metastatic Melanoma Patients: a Phase I/II Study - Full Text...
Adoptive Transfer of Specific Melanoma Antigens CD8+ T Cells in Metastatic Melanoma Patients: a Phase I/II Study (MelSort). The ... Adoptive Transfer of CD8+ T Cells, Sorted With HLA-peptide Multimers and Specific for Melan-A and MELOE-1 Melanoma Antigens, to ... This study evaluates the safety as well as the potential clinical efficacy of an adoptive transfer of CD8+ T cells, sorted with ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT02424916?term=melanoma&rank=18
Preliminary studies of artificial immunization of rats against Plasmodium berghei and adoptive transfer of this immunity by...  Preliminary studies of artificial immunization of rats against Plasmodium berghei and adoptive transfer of this immunity by...
Preliminary studies of artificial immunization of rats against Plasmodium berghei and adoptive transfer of this immunity by ... Preliminary studies of artificial immunization of rats against Plasmodium berghei and adoptive transfer of this immunity by ...
more infohttps://apps.who.int/iris/handle/10665/260892?locale-attribute=en
Prevention of Primary Simian Adenovirus Type 7 (SA7) Tumors in Hamsters by Adoptive Transfer of Lymphoid Cells: Role of...  Prevention of Primary Simian Adenovirus Type 7 (SA7) Tumors in Hamsters by Adoptive Transfer of Lymphoid Cells: Role of...
Spleen Cell Adoptive Transfer Peritoneal Exudate Cell Adult Hamster Phosphate Buffer Saline Solution Control These keywords ... Prevention of Primary Simian Adenovirus Type 7 (SA7) Tumors in Hamsters by Adoptive Transfer of Lymphoid Cells: Role of ... 25-28), or through adoptive transfer of specifically sensitized lymphoid cells (29-31). ... Tumors in Hamsters by Adoptive Transfer of Lymphoid Cells: Role of Different Cell Types. In: Wayne Streilein J., Hart D.A., ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4757-0495-2_16
Regression of Extensive Pulmonary Metastases in Mice by Adoptive Transfer of Antigen-Specific CD8+ CTL Reactive Against Tumor...  Regression of Extensive Pulmonary Metastases in Mice by Adoptive Transfer of Antigen-Specific CD8+ CTL Reactive Against Tumor...
... and with only one cycle of adoptive transfer. The addition of these reagents or multiple cycles of adoptive transfer may ... For recovery of CTL following adoptive transfer, lungs from mice receiving CTL (adoptively transferred, AT, lungs) or control ... The adoptive transfer of as few as 3 × 104 CMS4-reactive CTL was able to reduce tumor burden in the lung by approximately half ... The efficacy of adoptive transfer of the CMS4-reactive CTL line to mice bearing a larger tumor burden was tested in mice with ...
more infohttp://www.jimmunol.org/content/167/8/4286.long
Adoptive Transfer of Dendritic Cells Expressing Fas Ligand Modulates Intestinal Inflammation in a Model of Inflammatory Bowel...  Adoptive Transfer of Dendritic Cells Expressing Fas Ligand Modulates Intestinal Inflammation in a Model of Inflammatory Bowel...
Adoptive Transfer of Dendritic Cells Expressing Fas Ligand Modulates Intestinal Inflammation in a Model of Inflammatory Bowel ... Adoptive transfer of FasL-DCs decreased macroscopic and microscopic damage scores and reduced colonic T cells, neutrophils, and ... Adoptive Transfer of Dendritic Cells Expressing Fas Ligand Modulates Intestinal Inflammation in a Model of Inflammatory Bowel ... Citation: Rivera de Jesus E, Isidro RA, Cruz ML, Marty H, Appleyard CB (2016) Adoptive Transfer of Dendritic Cells Expressing ...
more infohttps://www.omicsonline.org/peer-reviewed/adoptive-transfer-of-dendritic-cells-expressing-fas-ligand-modulates-intestinal-inflammation-in-a-model-of-inflammatory-bowel-dise-72073.html
  • This study evaluates the safety as well as the potential clinical efficacy of an adoptive transfer of CD8+ T cells, sorted with HLA-peptide multimers and specific for Melan-A and MELOE-1 melanoma antigens, to patients suffering from advanced metastatic melanoma (stages IIIc and IV). (clinicaltrials.gov)
  • Adoptive Transfer of CD8+ T Cells, Sorted With HLA-peptide Multimers and Specific for Melan-A and MELOE-1 Melanoma Antigens, to Metastatic Melanoma Patients. (clinicaltrials.gov)
  • Hung was initially sent to Ten-Chen Medical Hospital, but was subsequently transferred to Tri-Service General Hospital when his body temperature had risen to 44 °C (108 °F). Hung died of organ failure on July 4, 2013, two days before he was due to be discharged from the military. (wikipedia.org)