Drug Administration Schedule
United States Food and Drug Administration
Drug Administration Routes
Dose-Response Relationship, Drug
Rats, Sprague-Dawley
Rats, Wistar
Injections, Intraperitoneal
Disease Models, Animal
Injections, Subcutaneous
Administration, Rectal
Liver
Biological Availability
Injections, Intramuscular
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Infusions, Intravenous
Half-Life
Drug Interactions
Area Under Curve
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Rats, Inbred Strains
Administration, Cutaneous
Tissue Distribution
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Dogs
Double-Blind Method
Cross-Over Studies
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Treatment Outcome
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Administration, Inhalation
Kidney
Infusions, Parenteral
Body Weight
Random Allocation
Drug Tolerance
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
Morphine
Plant Extracts
Analysis of Variance
Injections, Spinal
Metabolic Clearance Rate
Chromatography, High Pressure Liquid
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Rabbits
Lung
Analgesics, Opioid
Self Administration
Ethanol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Pregnancy
Estradiol
Drug Combinations
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Hemodynamics
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Drug Evaluation, Preclinical
Drug Therapy, Combination
Enzyme Inhibitors
Administration, Buccal
Prodrugs
Drug Approval
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Naloxone
Dopamine
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Genetic Therapy
Nitric Oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Hydrocortisone
Absorption
Cells, Cultured
Lipopolysaccharides
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Immunohistochemistry
Delayed-Action Preparations
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Pain Measurement
Pain
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Testosterone
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Microdialysis
Progesterone
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Genetic Vectors
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Growth Hormone
Administration, Intravaginal
Inflammation
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Antioxidants
Models, Animal
Drug Delivery Systems
Bile
United States Department of Veterans Affairs
Gonadotropin-Releasing Hormone
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
Drugs, Chinese Herbal
Pyridines
Luteinizing Hormone
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Diabetes Mellitus, Experimental
Neoplasms, Experimental
Prospective Studies
Mice, Nude
Device Approval
Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.
Mice, Transgenic
Neoplasm Transplantation
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Infusion Pumps
Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.
Pyrazoles
Glucocorticoids
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Methamphetamine
Serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Norepinephrine
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Neoplasms
Diazepam
Corticosterone
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Anesthesia
Chemistry, Pharmaceutical
Adrenocorticotropic Hormone
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Drug Carriers
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Central Nervous System Stimulants
Hyperalgesia
Neuroprotective Agents
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Leukocyte Count
Hypnotics and Sedatives
Gene Expression
Analgesics, Non-Narcotic
Intestines
Haloperidol
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
Drug-Induced Liver Injury
Imidazoles
Anti-Anxiety Agents
Indomethacin
Brain Chemistry
Placebos
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
Suppositories
Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
Hypothalamus
Gene Expression Regulation
Substance Withdrawal Syndrome
Adenoviridae
Iodine Radioisotopes
Edema
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Neurons
Nitric Oxide Synthase
Infusion Pumps, Implantable
Implanted fluid propulsion systems with self-contained power source for providing long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristatically controlled with the aid of transcutaneous monitoring.
Chorionic Gonadotropin
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
Feces
Blotting, Western
Narcotics
Oxidative Stress
Clinical Trials as Topic
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Erythropoietin
Endotoxins
Sheep
Immunoglobulin G
Myocardium
Nicotine
Amphetamine
A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
Injections, Intradermal
Corpus Striatum
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
Intestinal Mucosa
Lack of absorption of didanosine after rectal administration in human immunodeficiency virus-infected patients. (1/279)
The feasibility of rectal administration of didanosine (DDI) was studied in six human immunodeficiency virus-infected patients. After oral intake of a DDI solution (100 mg/m2 of body surface area) combined with an antacid (Maalox), pharmacokinetic parametric values were in accordance with previously published data; the mean +/- standard deviation for terminal half-life was 59.5 +/- 15.0 min, that for peak concentration was 5.2 +/- 3.9 mumol/liter, and that for the area under the time-concentration curve (AUC) was 494 +/- 412 min.mumol/liter. After rectal administration of a similarly prepared DDI solution (100 mg/m2 of body surface area), plasma DDI levels were below the detection limit (0.1 mumol/liter) at all time points in five of the six patients, and in the remaining patient the AUC after rectal application was only 5% of that after oral administration. We conclude that oral administration of DDI cannot be easily replaced by rectal application. (+info)Mucosal vaccination strategies for women. (2/279)
Women were immunized orally, rectally, or vaginally with a recombinant cholera toxin B-containing vaccine to determine which of these mucosal immunization routes generate the greatest levels of antibody in the female genital tract and rectum. ELISA was used to measure concentrations of cholera toxin B-specific IgA and IgG antibody in serum and secretions before and after three immunizations. Each immunization route similarly increased specific IgG in serum and specific IgA in saliva. Only the vaginal route increased IgA antibodies in genital tract secretions and could be shown to induce a local IgG response. However, vaginal immunization failed to produce antibody in the rectum. In a similar fashion, rectal immunization elicited highest concentrations of locally derived IgA and IgG antibody in the rectum but was ineffective for generating antibody in the genital tract. The data suggest that local immunization may induce the greatest immune responses in the female genital tract and rectum of humans. (+info)Trefoil peptide TFF2 (spasmolytic polypeptide) potently accelerates healing and reduces inflammation in a rat model of colitis. (3/279)
BACKGROUND: The trefoil peptides are major secretory products of mucus cells of the gastrointestinal tract and show increased expression after inflammatory or ulcerative damage. Recombinant human TFF2 (spasmolytic polypeptide) has been shown to be cytoprotective, and enhances repair in models of gastric injury. AIMS: To test the healing effects of recombinant human (h)TFF2 in a rat model of chronic colitis. METHODS: Colitis was induced by intracolonic administration of dinitrobenzene sulphonic acid in ethanol. Mucosal repair was quantified macroscopically, microscopically by image analysis of tissue histology, and by measuring myeloperoxidase activity. RESULTS: Initial validation studies showed that maximal injury and inflammation occurred at the end of the first week after colitis induction (active phase), and that spontaneous healing was complete by eight weeks. Once daily intrarectal application of hTFF2 (2.5 mg/kg; approximately 0.5 mg/rat) for five days after maximal damage had been sustained, reduced both microscopic and macroscopic injury by 80% and inflammatory index by 50% compared with vehicle controls. In addition, endogenous concentrations of rat TFF2 and TFF3 (intestinal trefoil factor) were increased in the active phase of colitis and were reduced to basal levels by hTFF2 treatment. CONCLUSIONS: This study has shown that hTFF2 enhances the rate of colonic epithelial repair, and reduces local inflammation in a rat model of colitis, and suggests that luminal application of trefoil peptides may have therapeutic potential in the treatment of inflammatory bowel disease. (+info)Efficient gene delivery to the inflamed colon by local administration of recombinant adenoviruses with normal or modified fibre structure. (4/279)
BACKGROUND/AIMS: Replication deficient recombinant adenoviruses represent an efficient means of transferring genes in vivo into a wide variety of dividing and quiescent cells from many different organs. Although the gastrointestinal tract is a potentially attractive target for gene therapy approaches, only a few studies on the use of viral gene transfer vehicles in the gut have been reported. The prospects of using recombinant adenoviruses for gene delivery into epithelial and subepithelial cells of the normal and inflamed colon are here analysed. METHODS: An E1/E3 deleted recombinant adenovirus (denoted AdCMVbetaGal) and an adenovirus with modified fibre structure (denoted AdZ.F(pk7)) both expressing the bacterial lacZ gene under the control of a human cytomegalovirus promoter were used for reporter gene expression in vitro and in vivo. beta-Galactosidase activity was determined by specific chemiluminescent reporter gene assay. RESULTS: Intravenous or intraperitoneal injection of AdCMVbetaGal into healthy Balb/c mice caused strong reporter gene expression in the liver and spleen but not in the colon. In contrast, local administration of AdCMVbetaGal resulted in high reporter gene expression in colonic epithelial cells and lamina propria mononuclear cells. A local route of adenovirus administration in mice with experimental colitis induced by the hapten reagent trinitrobenzenesulphonic acid was next evaluated. Interestingly, rectal administration of AdCMVbetaGal caused a higher beta-galactosidase activity in isolated lamina propria cells from infected mice with experimental colitis than in those from controls. Furthermore, isolated lamina propria cells from mice with colitis infected in vitro showed a significant increase in reporter gene activity compared with controls. Finally, AdZ.F(pk7) adenoviruses with modified fibre structure produced 10- to 40-fold higher reporter gene activity in spleen T cells and lamina propria mononuclear cells of colitic mice compared with standard AdCMVbetaGal vectors. CONCLUSIONS: Local administration of recombinant adenoviruses with normal or modified fibre structure could provide a new reliable method for targeted gene expression in the inflamed colon. Such gene delivery could be used to specifically express signal transduction proteins with therapeutic potential in inflamed colonic tissue. In particular, adenoviruses with modified fibre structure may be useful in T cell directed therapies in intestinal inflammation. (+info)Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates. (5/279)
AIM: To investigate the pharmacokinetics, metabolism, and dose-response relation of a single rectal dose of paracetamol in preterm infants in two different age groups. METHODS: Preterm infants stratified by gestational age groups 28-32 weeks (group 1) and 32-36 weeks (group 2) undergoing painful procedures were included in this study. Pain was assessed using a modified facies pain score. RESULTS: Twenty one infants in group 1 and seven in group 2 were given a single rectal dose of 20 mg/kg body weight. Therapeutic concentrations were reached in 16/21 and 1/7 infants in groups 1 and 2, respectively. Peak serum concentrations were significantly higher in group 1. Median time to reach peak concentrations was similar in the two groups. As serum concentration was still in the therapeutic range for some infants in group 1, elimination half life (T1/2) could not be determined in all infants: T1/2 was 11.0 +/- 5.7 in 11 infants in group 1 and 4.8 +/- 1.2 hours in group 2. Urinary excretion was mainly as paracetamol sulphate. The glucuronide:sulphate ratio was 0.12 +/- 0.09 (group 1) and 0.28 +/- 0.35 (group 2). The pain score did not correlate with therapeutic concentrations. CONCLUSIONS: A 20 mg/kg single dose of paracetamol can be safely given to preterm infants in whom sulphation is the major pathway of excretion. Multiple doses in 28-32 week old neonates would require an interval of more than 8 hours to prevent progressively increasing serum concentrations. (+info)Anatomic segmentation of the intestinal immune response in nonhuman primates: differential distribution of B cells after oral and rectal immunizations to sites defined by their source of vascularization. (6/279)
We show that the distribution of specific antibodies and antibody-secreting cells in the intestine after oral and rectal immunizations corresponds to the vascularization and lymph drainage patterns of the gut. Oral immunizations induce antibody responses along the parts of the intestine connected to the superior mesenteric vessels and lymph ducts, whereas rectal immunizations induce antibody responses along the parts of the intestine associated with the inferior mesenteric vessels and ducts. (+info)Rectally administered dimenhydrinate reduces postoperative vomiting in children after strabismus surgery. (7/279)
We have investigated the effectiveness of rectally administered dimenhydrinate on postoperative vomiting in children undergoing strabismus surgery, in a double-blind, randomized, placebo-controlled study. In one group, dimenhydrinate 50 mg was administered rectally 30 min before starting anaesthesia, whereas in the control group, placebo suppositories were given. Children who received dimenhydrinate showed a significantly (P < 0.001) lower incidence of vomiting (15%) than those in the control group (75%). We conclude that rectal administration of dimenhydrinate is an effective means of reducing postoperative vomiting in children undergoing strabismus surgery. (+info)Investigation of diazepam lipospheres based on Witepsol and lecithin intended for oral or rectal delivery. (8/279)
Diazepam was incorporated in lipospheres prepared by high pressure homogenization of melted Witepsol (10%) dispersed in aqueous lecithin (2.4%). Diazepam content was 0.4% and more than 98% of the dose was found to be encapsulated in the lipospheres. Although the initial mean particle size was 0.3 micron, the liposhperes agglomerated during storage and this phenomenon was not eliminated by increasing lecithin concentration to 4% or incorporation of oleic acid (0.1%) and co-surfactants, polysorbate 80 (0.5%) or poloxamer (up to 6%). The formulation was not able to mask effectively bitter taste of diazepam, even when lipids of higher melting temperature, namely glyceryl tripalmitate or stearic acid, were introduced. (+info)
Rectal Administration
Summary Report | CureHunter
AEDs for Rectal Administration | Epilepsy Foundation
FOR ORAL OR RECTAL ADMINISTRATION FOR THE PREVENTION AND TREATMENT OF PORTAL-SYSTEMIC ENCEPHALOPATHY - PDF
IRMA - Rectal Microbicide Advocacy: IRMA-ALC Promotes Rectal Microbicides in Lima with Humor and Tia Irma
IRMA - Rectal Microbicide Advocacy: Meet Suwat Chariyalertsak - A Friendly Rectal Microbicide Advocate from Thailand
Pharmacokinetic studies following intravenous and rectal administration of midazolam in children]
Anticholinergics And Antispasmodics (Oral Route, Parenteral Route, Rectal Route, Transdermal Route) Description and Brand Names...
Antihistamine (Oral Route, Parenteral Route, Rectal Route) Proper Use - Mayo Clinic
The Toxoplasma Blog: May 2012
Global Campaign for Microbicides : Rectal Microbicides
Diazepam (rectal)
Patent US4425337 - Adjuvants for rectal delivery of drug - Google Patents
M Clervil | West Indian Medical Journal
The Paramedics Diary: August 2007
6 oz Stainless Steel Dose Syringe
Big Dees Horse Tack & Vet Supplies
Question what are the different routes of administration of drugs?
Citizen News Service - CNS: Reduced glycerin formulation of a rectal microbicide gives hope
Researchers launch first-ever phase II safety study of rectal microbicide to prevent HIV
rectum - IRMA
LifeLube: HIV Vaccine Discovery: Antibodies discovered that block HIV strains
Requip | Semantic Scholar
View all posts by Silvia Mendonca
A Study of Male Rectal Samples in Preparation for Future Rectal Microbicide Trials - Full Text View - ClinicalTrials.gov
A Study of Male Rectal Samples in Preparation for Future Rectal Microbicide Trials - Full Text View - ClinicalTrials.gov
Salicylate (Oral route, rectal route)
Influence of the dissolution medium on the release of dehydroepiandrosterone from lipophilic suppositories : Current Issues in...
Thiethylperazine (Oral route, intramuscular route, rectal route)
OC-025 The first report of the UK multicentre double balloon enteroscopy registry: broadening the international deep...
Drug Discoveries & Therapeutics - Abstract
Inflammatory Bowel Disease | ACG Patients
Oxymorphone - Wikipedia
Cefpodoxime for dogs side effects / Minocin 100 mg y alcohol
Avis melanex trio noviderm 10mg accutane a day omnicef 100 lipitor iron deficiency
Original Drugstore: Viagra efeito video highest quality
Anugesic-Hc Suppository
Piroxicam hexal compresse : Furosemid wirkung nebenwirkung
dulcolax suppository during pregnancy
Acetaminophen rectal suppositories
Krames Online - Acetaminophen rectal suppositories
Acetaminophen rectal suppositories
猴免疫缺陷病毒 - 维基百科,自由的百科全书
Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the...
MCC Paramedic Flashcards
Sporanox costo, Sporanox utilisation
Miralex MiLAX-M glycerol suppositories 2500mg for adults x 10 suppositories | SHiFT SToRE
Alniche Life Sciences Pvt. Ltd.
EDGE Atlantic City, NJ :: Cannabis Rectal Suppositories are Recognized as a Posh Alternative to Poppers
Dynapar 100mg Suppository : Uses, Price, Side Effects, Composition, Substitutes, Precautions and Advice - Troikaa...
Suppositories Medicines - Metroealth Suppository Exporter from Navi Mumbai
Suppositories, Suppositories Supplier, Exporter,Manufacturer
RX-Canada: Typical cialis cost any pills online!
Vax Report - Understanding Microbicide Development
How to Make Homemade Suppositories - Green Health Tips - Health & Fitness News
How long after I stop taking progesterone suppositories will my period return - Doctors answer your questions
Preparation H Suppositories Uses, Side Effects & Warnings - Drugs.com
What Are the Concerns about Pregnancy and Suppositories?
Neo healer suppositories cheapest price - Oxyhives for hives relief - Nov 7, 2017
Carlson Labs Key E Suppositories - 12 Units - eVitamins.com
Care Glycerin Suppositories 4g* - Care
Paraldehyde
Rectal. It may be mixed 1 part paraldehyde with 9 parts saline or, alternatively, with an equal mixture of peanut or olive oil ... Intravenous administration can lead to pulmonary edema, circulatory collapse and other complications. Oral. Paraldehyde has a ... rubber and plastic which limits the time it may safely be kept in contact with some syringes or tubing before administration. ...
Morphine
Recently, one study has used an animal model (hind-paw incision) to observe the effects of morphine administration on the acute ... or via rectal suppository. It acts directly on the central nervous system (CNS) to induce analgesia and alter perception and ... After IM or SC injections, morphine plasma levels peak in approximately 20 min, and, after oral administration, levels peak in ... The authors suggest that morphine administration in the acute post-injury period may reduce resistance to infection and may ...
End-of-life care
Moolenaar F, Koning B, Huizinga T (1979). "Biopharmaceutics of rectal administration of drugs in man. Absorption rate and ... de Boer AG, Moolenaar F, de Leede LG, Breimer DD (1982). "Rectal drug administration: clinical pharmacokinetic considerations ... is a specialized catheter designed to provide comfortable and discreet administration of ongoing medications via the rectal ... The catheter was developed to make rectal access more practical and provide a way to deliver and retain liquid formulations in ...
Enema
Improper administration of an enema can cause electrolyte imbalance (with repeated enemas) or ruptures to the bowel or rectal ... Rectal douching is a common practice among people who take a receptive role in anal sex although rectal douching before anal ... de Boer AG, Moolenaar F, de Leede LG, Breimer DD (1982). "Rectal drug administration: clinical pharmacokinetic considerations ... Oral and rectal use of the solution has also been promoted as a cure for HIV, malaria, viral hepatitis, influenza, common colds ...
Knee-chest position
"Administration of Rectal Suppositories or Enemas". Latest FDA Medication Alert. Institute for Safe Medication Practices. ... "Enema Administration". Study - Flashcards. Quizlet. Retrieved 2019-06-15. v t e (Articles with short description, Short ...
Medroxyprogesterone acetate
van Hoogdalem EJ, de Boer AG, Breimer DD (August 1991). "Pharmacokinetics of rectal drug administration, Part II. Clinical ... Overdose is not described in the Food and Drug Administration (FDA) product labels for injected MPA (Depo-Provera or Depo-SubQ ... On 17 November 2004, the United States Food and Drug Administration put a black box warning on the label, indicating that there ... Administration of medroxyprogesterone acetate (MPA) to certain sex offenders". Louisiana Revised Statutes. Retrieved 8 July ...
Suppository
Lowry, Michael (2016-02-22). "Rectal drug administration in adults: how, when, why". Nursing Times. Vol. 112, no. 8, 12-14. ... Abd-El-Maeboud, K. H.; T. El-Naggar; E. M. M. El-Hawi; S. A. R. Mahmoud; S. Abd-El-Hay (28 September 1991). "Rectal suppository ... Rectal suppositories are intended for localized or systemic action to relieve pain, constipation, irritation, inflammation, ... There are three types of suppositories, each to insert into a different sections: rectal suppositories into the rectum, vaginal ...
Pharmacokinetics of testosterone
Rectal administration of testosterone avoids the first-pass effect with oral administration similarly to other non-oral routes ... Rectal use of testosterone requires administration two or three times per day to maintain adequate testosterone levels. The ... Testosterone was marketed as a suppository for rectal administration by Ferring Pharmaceuticals from the early 1960s under ... As a result, it requires administration several times per day in divided doses. Due to its limitations, such as the high doses ...
Nicomorphine
Pharmacokinetics via the rectal route differ, and change metabolism. Eight minutes after administration, morphine appeared ... Koopman-Kimenai PM, Vree TB, Booij LH, Dirksen R (December 1994). "Rectal administration of nicomorphine in patients improves ... "Pharmacokinetics of nicomorphine and its metabolites in man after epidural administration". Pharmaceutisch Weekblad. Scientific ...
Fecal microbiota
... is the first fecal microbiota product approved by the US Food and Drug Administration (FDA). Fecal microbiota ... "Rebyota (fecal microbiota, live - jslm) suspension, for rectal use". Ferring Pharmaceuticals Inc. November 2022. https://www. ... "FDA Approves First Fecal Microbiota Product". U.S. Food and Drug Administration (FDA). 30 November 2022. Retrieved 1 December ... fda.gov/media/163587/download "Rebyota". U.S. Food and Drug Administration. 30 November 2022. Retrieved 4 December 2022. " ...
Artesunate
... rectal administration may be given as pre-referral treatment as long as parenteral administration is initiated after transfer ... oral or rectal administration". Malaria Journal. 10: 263. doi:10.1186/1475-2875-10-263. PMC 3180444. PMID 21914160. Hess KM, ... Artesunate combination drugs have a number of advantages over artemether-based drugs in terms of its uptake and administration ... "Artesunate Orphan Drug Designation and Approval". U.S. Food and Drug Administration (FDA). 5 September 2017. Retrieved 27 May ...
Estriol (medication)
Rectal administration of estriol has been assessed in one study. Administration of a rectal suppository containing 100 mg ... Moran DJ, McGarrigle HH, Lachelin GC (January 1994). "Maternal plasma progesterone levels fall after rectal administration of ... The bioavailability of estriol is markedly increased with vaginal administration compared to oral administration. The relative ... Vaginal administration of low doses of 30 µg estriol and of higher doses of 0.5 and 1 mg estriol have been found to produce ...
Dostarlimab
In 2022, an early clinical study of dostarlimab reported a 100% remission rate in 14 patients with rectal cancer who had ... "FDA grants accelerated approval to dostarlimab-gxly for dMMR advanced solid tumors". U.S. Food and Drug Administration (FDA). ... In August 2021, the US Food and Drug Administration (FDA) granted accelerated approval to dostarlimab for adults with mismatch ... Based on the GARNET trial, Dostarlimab (Jemperli) gained accelerated approval from the Food and Drug Administration (FDA) in ...
Batt Thornhill
Thornhill died from rectal cancer aged 59 on 16 October 1970. He was the first member of Cork's four-in-a-row side to die. ... In retirement from playing, Thornhill remained heavily involved in the administration and organisation of the Buttevant club. A ...
Colorectal cancer
Rectal bleeding or anemia are high-risk symptoms in people over the age of 50. Weight loss and changes in a person's bowel ... Food and Drug Administration. February 9, 2019. Cercek A, Lumish M, Sinopoli J, Weiss J, Shia J, Lamendola-Essel M, El Dika IH ... Stage IV rectal cancer is treated similar to stage IV colon cancer. Stage IV colorectal cancer due to peritoneal carcinomatosis ... The decision to add chemotherapy in management of colon and rectal cancer depends on the stage of the disease. In Stage I colon ...
Antiarthritics
There are various routes of administration including oral, rectal and intravenous. Acetaminophen is often recommended in ... Route of administration includes oral tablets and liquids as well as intravenous and subcutaneous injections into the skin. ... The route of administration is available through intravenous or subcutaneous injection. Biologic response modifiers are ... These drugs are typically given orally, topically or through administration by injection. The choice of antiarthritic ...
Medical fetishism
... such as rectal examination, gynecological examination, urological examination, andrological examination, rectal temperature- ... This may be a prelude to masturbation or administration of an enema. Before examination, the patient can be placed in physical ... Temperature-taking fetish is a sexual fetish for oral and rectal thermometers. This may include the sexual attraction to the ... Although there is also an interest in oral temperature taking, rectal temperature-taking is more prominent and often precedes ...
Migraine
The adverse effects associated with rectal administration have not been well studied. Some people may find that they respond to ... Derry, Christopher J.; Derry, Sheena; Moore, R. Andrew (2012-02-15). "Sumatriptan (rectal route of administration) for acute ... All route of administration have been shown to be effective at reducing migraine symptoms, however, nasal and injectable ... "FDA allows marketing of first medical device to prevent migraine headaches". Food and Drug Administration. 11 March 2014. ...
Papaverine
The hydrochloride salt is available for intramuscular, intravenous, rectal and oral administration. The teprosylate is ...
Diazepam
Dhillon S, Oxley J, Richens A (March 1982). "Bioavailability of diazepam after intravenous, oral and rectal administration in ... The onset of action is one to five minutes for IV administration and 15-30 minutes for IM administration. The duration of ... after rectal administration, peak plasma levels occur after 10 to 45 minutes. Diazepam is highly protein-bound, with 96 to 99% ... III): Intravenous self-administration of some CNS-affecting drugs and a new sleep-inducer, 1H-1, 2, 4-triazolyl benzophenone ...
Hiccup
The Food and Drug Administration approved the vagus nerve stimulator in 1997 as a way to control seizures in some patients with ... Odeh M, Bassan H, Oliven A (February 1990). "Termination of intractable hiccups with digital rectal massage". Journal of ... epilepsy." Persistent digital rectal massage has also been proven effective in terminating intractable hiccups. There are many ...
Ergotamine
"Low bioavailability of ergotamine tartrate after oral and rectal administration in migraine sufferers". British Journal of ... The low oral and rectal bioavailability is due to low gastrointestinal absorption and high first-pass metabolism. Ergotamine is ... "Lists of: Scheduling Actions, Controlled Substances, Regulated Chemicals" (PDF). Drug Enforcement Administration, Diversion ... Food and Drug Administration. 2020. "CAFERGOT- ergotamine tartrate and caffeine tablet, film coated". DailyMed. U.S. National ...
Vinylbital
"Pharmacokinetics and relative bioavailability of vinylbital in man after oral and rectal administration". Arzneimittel- ...
Personal lubricant
Healthline (2018-09-17). "Enema Administration". Enema Administration - How an enema is administered. Healthline. Retrieved ... Rectal use of lubricants is viewed by the agency as an off-label application.[citation needed] In 2012 it was reported that ... Enema and rectal thermometer tips should be lubricated before use to minimize friction while inserting through the tightly ... The US Food and Drug Administration (FDA) regulates lubricant as a medical device rather than as a cosmetic. Because of strict ...
Apomorphine
Other non-invasive administration routes were investigated as a substitute for parenteral administration, reaching different ... van Laar T, Jansen EN, Neef C, Danhof M, Roos RA (July 1995). "Pharmacokinetics and clinical efficacy of rectal apomorphine in ... IV administration of apomorphine is highly discouraged, as it can crystallize in the veins and create a blood clot (thrombus) ... Toxicity depends on the route of administration; the LD50s in mice were 300 mg/kg for the oral route, 160 mg/kg for ...
Artemisinin
For children less than six years old, if injected artesunate is not available the WHO recommends rectal administration of ... Therefore, it is typically administered via the digestive tract, either by oral or rectal administration. Artesunate however ... oral or rectal administration". Malaria Journal. 10 (1): 263. doi:10.1186/1475-2875-10-263. PMC 3180444. PMID 21914160. ... One derivative, SM934, was approved in 2015 by the Chinese National Medical Products Administration for a clinical trial as a ...
Promethazine
"Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects ... as a rectal suppository, or by injection into a muscle. Common side effects of promethazine include confusion and sleepiness; ... Food and Drug Administration. 2013-08-15. "Promethazine". U.S. National Library of Medicine and National Institutes of Health ... approved by the US Food and Drug Administration (FDA), are deemed insufficient by state courts. On September 9, 2009, the FDA ...
Pharmacokinetics of progesterone
Daily rectal administration of progesterone is inconvenient and poorly accepted for long-term therapy. Nonetheless, rectal ... Hormone levels with rectal progesterone Progesterone levels with vaginal or rectal administration of a suppository containing ... Progesterone can be taken by rectal administration. A suppository sold under the brand name Cyclogest is indicated for rectal ... A number of studies have assessed progesterone by the rectal route. Levels of progesterone following rectal administration have ...
THC hemisuccinate
October 1991). "Rectal bioavailability of delta-9-tetrahydrocannabinol from the hemisuccinate ester in monkeys". Journal of ... and was developed to overcome the poor bioavailability of THC when taken by non-inhaled routes of administration. THC-O-acetate ... THC-O-phosphate SP-111 Elsohly MA, Little TL, Hikal A, Harland E, Stanford DF, Walker L (November 1991). "Rectal ...
Dienestrol
It has been studied for use by rectal administration in the treatment of prostate cancer in men as well. The medication was ... Rectal administration of estrogens in prostate carcinoma]. Minerva Urol (in Italian). 5 (1): 28-32. ISSN 0026-4989. PMID ...
ആസ്പിരിൻ - വിക്കിപീഡിയ
administration. Most commonly oral, also rectal. Lysine acetylsalicylate may be given IV or IM. ...
Cannabinoid
US Food and Drug Administration. September 2004. Retrieved 14 January 2018.. *^ "Cannabis and Cannabinoids". National Cancer ... or rectal suppository. Once in the body, most cannabinoids are metabolized in the liver, especially by cytochrome P450 mixed- ... The CBD drug Epidiolex has been approved by the Food and Drug Administration for treatment of two rare and severe forms of ... Nabiximols (brand name Sativex) is an aerosolized mist for oral administration containing a near 1:1 ratio of CBD and THC.[44] ...
인간면역결핍 바이러스 - 위키백과, 우리 모두의 백과사전
Global Campaign for Microbicides : Rectal Use of N-9 Archived 2012년 8월 21일 - 웨이백 머신 checked 2009-07-22 ... "Condoms and Sexually Transmitted Diseases, Brochure》. United States Food and Drug Administration. 2009년 4월 30일. 2009년 7월 23일에 ...
Infusion pump
Food and Drug Administration (FDA) has launched a comprehensive initiative to improve their safety, called the Infusion Pump ... with the device coded to stop administration before a dose that may cause hazardous respiratory depression is reached. ... and the needed pressure varies with the administration route, potentially causing risk when attempted by an individual not ...
Nervi - Viquipèdia, l'enciclopèdia lliure
Curran, T; Poylin, V; Kane, R; Harris, A; et al «Case report of a traumatic rectal neuroma» (en anglès). Gastroenterol Rep (Oxf ... A Case Report on a Rare but Serious Debilitating Side-Effect of Fluoroquinolone Administration» (en anglès). J Investig Med ... Araki T, Takeshita S, Kawasaki H, Kusumoto K, et al «A Case of Rectal Paraganglioma» (en anglès). Intern Med, 2018; Ag 24, pàgs ... Haraguchi M, Kinoshita H, Koori M, Tsuneoka N, et al «Multiple rectal carcinoids with diffuse ganglioneuromatosis» (en anglès ...
Neutropenia
The administration of intravenous immunoglobulins (IVIGs) has had some success in treating neutropenias of alloimmune and ... Rectal examinations are usually not performed due to the increased risk of introducing bacteria into the blood stream and the ... reduce the occurrence of chemotherapy-induced neutropenia and the associated need for interventions such as the administration ...
Computer-aided diagnosis
Suppression of rectal tubes". Medical Physics. 33 (10): 3814-3824. Bibcode:2006MedPh..33.3814S. doi:10.1118/1.2349839. ISSN ... was approved by the US Food and Drug Administration (FDA). In the following years several commercial CAD systems for analyzing ...
അട്രൊപിൻ - വിക്കിപീഡിയ
administration. Oral, IV, IM, rectal. Pharmacokinetic data. Bioavailability. 25%. Metabolism. 50% hydrolysed to tropine and ...
Hypodermic needle
The trend of needle specification for use began in the 1920s, particularly for the administration of insulin to diabetics.[15] ... The onset of World War II spurred the early development of partially disposable syringes for the administration of morphine and ... Hypodermic needles remain essential to large volume administration or exchange in settings of trauma or dialysis. ...
Organ-on-a-chip
Oral administration is one of the most common methods for drug administration. It allows patients, especially out-patients, to ... Eubacterium rectale, and Bacteroides thetaiotaomicron.[27] ... distribution reaches a rapid equilibrium after administration. ...
Aspirin
administration. By mouth, rectal; lysine acetylsalicylate may be given intravenously or intramuscularly. ... "U.S. Food and Drug Administration (FDA). 9 July 2015. Archived from the original on 11 July 2015. Retrieved 9 July 2015.. ... "U.S. Food and Drug Administration (FDA) (Press release). 15 October 2020. Retrieved 15 October 2020.. ... Results of a Veterans Administration Cooperative Study". New England Journal of Medicine. 309 (7): 396-403. doi:10.1056/ ...
Ibuprofen - Wikipédia Sunda, énsiklopédi bébas
by mouth, rectal, topical, and intravenous Ibuprofen nyaéta ubar antiinflamasi non-steroid (NSAID) nu dipaké pikeun ngubaran ... "Therapeutic Goods Administration. 31 July 2012. Diarsipkan dari versi asli (PDF) tanggal 20 August 2016. Diakses tanggal 8 May ...
Skin and skin structure infection
The U.S. Food and Drug Administration began referring to this category of infection as acute bacterial SSSIs (ABSSSI) in 2008. ... such as the rectal area, where the risk of anaerobic or Gram-negative pathogen involvement is higher, [were also] considered ... Food and Drug Administration. October 2013. Retrieved 2014-11-23. Xia, Fan Di; Song, Philip; Joyce, Cara; Mostaghimi, Arash ( ... Food and Drug Administration. Aug 2010. Rosen, T (2005). "Update on treating uncomplicated skin and skin structure infections ...
Oxycodone
The bioavailability of oral administration of oxycodone averages within a range of 60 to 87%, with rectal administration ... Therapeutic Goods Administration (June 2008). Standard for the uniform scheduling of drugs and poisons no. 23 (PDF). Canberra: ... When first introduced in Germany during World War I, both IV and IM administrations of oxycodone were commonly used for ... Drug Enforcerment Administration. Archived from the original on 21 November 2015. Retrieved 23 November 2015. "DEA Diversion ...
Bacteriotherapy
Administration routes are typically decided on a case-by-case basis and account for some differences in resolution and relapse ... gentle rectal enema, or colonoscopy. Research is currently being done to see if FMT can be encapsulated and taken orally as a ... Administration of an Autism Diagnostic Observation Schedule (ADOS) showed a 3-point decrease in score (i.e. an improvement in ... Further research on FMT is required to directly compare routes of administration, optimal protocol for infusions, and ideal ...
Prostate cancer
Digital rectal examination may allow a doctor to detect prostate abnormalities. Cystoscopy shows the urinary tract from inside ... "FDA approves Zytiga for late-stage prostate cancer". U.S. Food and Drug Administration. 2011-04-28. Archived from the original ... Options include the digital rectal exam and the PSA blood test. Such screening is controversial, and for many, may lead to ... The monitoring process may involve PSA tests, digital rectal examination, or repeated biopsies every few months. The goal of ...
Textile industry in Bangladesh
Occupational Safety & Health Administration. Retrieved 29 October 2016 New Jersey Department of Health and Senior Service. ... rectal, nasopharyngeal and lung cancers. Studies have postulated that hypersensitivity effects may be due to alterations in ...
Democratic Action Party
During the Mahathir administration in 1987, several DAP leaders, including Parliamentary Opposition Leader Lim Kit Siang, were ... Chong Eng took over for Kerk Kim Hock while the latter sought treatment for rectal cancer. M. Kulasegaran was Acting Secretary- ... "Election 2008 Results: Lim Guan Eng is next Penang CM, promises fair & just administration". New Straits Times. Archived from ...
Anal sac adenocarcinoma
Smaller tumors are undetectable without a rectal examination, while larger tumors can cause pain and straining to defecate. ... and furosemide administration for hypercalcemia of malignancy". J Am Anim Hosp Assoc. 40 (1): 75-81. PMID 14736909. Gröne A, ...
Cancer
The administration of human papillomavirus and hepatitis B vaccinations is recommended where resources allow. Unlike diagnostic ... Ulceration can cause bleeding that can lead to symptoms such as coughing up blood (lung cancer), anemia or rectal bleeding ( ...
Midazolam
Paradoxical reactions are particularly associated with intravenous administration. After nighttime administration of midazolam ... Brigo F, Nardone R, Tezzon F, Trinka E (August 2015). "Nonintravenous midazolam versus intravenous or rectal diazepam for the ... It is not clear whether his death was caused by one or more of the drugs or by a problem in the administration procedure, nor ... Atorvastatin administration along with midazolam results in a reduced elimination rate of midazolam. St John's wort decreases ...
Methylenedioxypyrovalerone
It has been shown to produce robust reinforcing effects and compulsive self-administration in rats, though this had already ... Reported modalities of intake include oral consumption, insufflation, smoking, rectal and intravenous use. It is supposedly ... "Chemicals Used in "Bath Salts" Now Under Federal Control and Regulation" (Press release). Drug Enforcement Administration (DEA ...
Radiation therapy
It is typically used for treating early rectal cancer in patients who may not be candidates for surgery. A 2015 NICE review ... In 2002, the United States Food and Drug Administration (FDA) approved ibritumomab tiuxetan (Zevalin), which is an anti-CD20 ... Sun Myint A, Gerard J, Myerson RJ (2014). "Contact X-Ray Brachytherapy for Rectal Cancer". In Longo WE, Reddy V, Audisio RA ( ... Intestinal discomfort The lower bowel may be treated directly with radiation (treatment of rectal or anal cancer) or be exposed ...
List of United States Marine Corps acronyms and expressions
Silver Bullet - Rectal thermometer used to check the core temperature of a person suffering from heat-related injuries, such as ... Box-kicker - Pejorative for a Marine who works in supply (either the MOS 3043 (Supply Administration) or usually a 3051 - ( ... SMEAC - Situation, Mission, Execution, Administration & Logistics, Commands & Signals. The acronym used for the five-paragraph ...
Domperidone
... and by rectal administration in the form of suppositories. The oral tablets are available in the strength of 10 mg. Domperidone ... but the medication is now only available in forms for oral and rectal administration. Domperidone is contraindicated with QT- ... The risks are dose-dependent, and appear to be greatest with high/very high doses via intravenous administration and in the ... There is a 2- to 3-fold accumulation in levels of domperidone with frequent repeated oral administration of domperidone (four ...
Dr. Young's Ideal Rectal Dilators
According to the U.S. Food and Drug Administration's subsequent Drugs and Devices Court Case Notice of Judgment (captioned "U.S ... Young's Rectal Dilators and Dr. Young's Piloment. U. S. v. 67 Sets of Dr. Young's Rectal Dilators and 83 Packages of Dr. ... Young's Rectal Dilators". thequackdoctor.com. 2 November 2009. US Design Patent 21,551 "Design for a rectal dilator" (Frank E. ... Young's Ideal Rectal Dilators were medical devices sold in the United States from the late nineteenth century until at least ...
Rectal administration - Wikipedia
Wikimedia Commons has media related to Rectal administration. Enema Rectal discharge Routes of administration Suppository The ... Rectal administration uses the rectum as a route of administration for medication and other fluids, which are absorbed by the ... Finally, rectal administration can allow patients to remain in the home setting when the oral route is compromised. Unlike ... The rectal route of administration is useful for patients with any digestive tract motility problem, such as dysphagia, ileus, ...
Rectal thermometers are the most accurate, says study
A new study shows rectal thermometers are more precise than so-called peripheral thermometers, like those that are held under ... Biden administration unveils dashboard to track nonfatal drug overdoses Biden administration unveils dashboard to track ... Ive always had rectal from since Ive been little and always still take rectal Ive never known any other method so to me ... My mom said that if I do it the best way first and last is rectal and rectal . No other way is true she said. ...
L'utilisation de l'artésunate rectal comme traitement pré-transfert pour le paludisme grave à P. falciparum : note d'information
administration and dosage. en_US. who.relation.languageVersion. 10665/351187. en_US. ... Lutilisation de lartésunate rectal comme traitement pré-transfert pour le paludisme grave à P. falciparum : note ... Lutilisation de lartésunate rectal comme traitement pré-transfert pour le paludisme grave à P. falciparum : note ...
Fleet Mineral Oil Enema (mineral oil rectal) dosing, indications, interactions, adverse effects, and more
... mineral oil rectal), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation ... Administration. Patient should lie on left side with right knee bent. Gently insert enema tip into rectum using slight side-to- ... encoded search term (mineral oil rectal (Fleet Mineral Oil Enema)) and mineral oil rectal (Fleet Mineral Oil Enema) What to ... Administration. Patient should lie on left side with right knee bent. Gently insert enema tip into rectum using slight side-to- ...
Administration, Rectal | The Chopra Library
ARTS and rectal DHA administration. METHODS: Twelve Vietnamese patients with uncomplicated falciparum malaria were randomized ... rectal administration and then offered artesunate suppositories as treatment of their child. ... A further 12 patients were given i.v. ARTS (120 mg) at 0 h and rectal DHA (160 mg) 8 h later. RESULTS: Following i.v. ... BACKGROUND: Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural ...
Bacterial Mixture vs FMT vs Vancomycin for C. diff Infection
Might rectal bacteriotherapy be a safer alternative to fecal microbiota transplantation for recurrent C. difficile infection? ... We hypothesised that rectal bacteriotherapy and FMT were superior to vancomycin and that rectal bacteriotherapy was non- ... Administration. Enema by a catheter (Ch 12, diam. 4 mm) inserted rectally approximately 20-30 cm up with participants in left ... Before FMT and rectal bacteriotherapy, we pre-treated with vancomycin for 7-14 days. Rectal bacteriotherapy was applied by ...
Vomiting blood: MedlinePlus Medical Encyclopedia
L'utilisation de l'artésunate rectal comme traitement pré-transfert pour le paludisme grave à P. falciparum : note d'information
administration and dosage. en_US. who.relation.languageVersion. 10665/351187. en_US. ... Lutilisation de lartésunate rectal comme traitement pré-transfert pour le paludisme grave à P. falciparum : note ... Lutilisation de lartésunate rectal comme traitement pré-transfert pour le paludisme grave à P. falciparum : note ...
July 1931 - Volume 31 - Issue 7 : AJN The American Journal of Nursing
Kayexalate (Sodium Polystyrene): Uses, Dosage, Side Effects, Interactions, Warning
KAYEXALATE is not absorbed systemically following oral or rectal administration and maternal use is not expected to result in ... Preparation And Administration. Prepare suspension fresh and use within 24 hours.. Do not heat KAYEXALATE as it could alter the ... Concomitant administration of sorbitol is not recommended.. *Use only in patients who have normal bowel function. Avoid use in ... see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS].. Nonclinical Toxicology. Carcinogenesis, Mutagenesis, Impairment Of ...
Mycobacterium caprae Infection in Captive Borneo Elephant, Japan - Volume 24, Number 10-October 2018 - Emerging Infectious...
First Study to Evaluate the Capacity of Maraviroc Drug to Protect Against HIV Infection in Samples of Rectal Mucosa From...
PILOT STUDY OF PROTECTION AGAINST ex Vivo HIV INFECTION IN RECTAL MUCOSA IN HEALTHY VOLUNTEERS AFTER ADMINISTRATION OF ... Maraviroc levels in rectal mucosa [ Time Frame: Visit 1 (Group 1: day 8, Group 2: day 7, Grop 3: day 9) ]. *Truvada plasmatic ... The HIV production in ex vivo cultures from the basal and after drug administration will be compared and the results will be ... The HIV production in ex vivo cultures from the basal and after drug administration will be compared and the results will be ...
Beauty of the beast: anticholinergic tropane alkaloids in therapeutics | SpringerLink
In earlier times, rectal administration (0.01 mg/kg) was a preferred method of atropine delivery in children to slow down ... Plasma concentrations of atropine after rectal administration. Anaesthesia. 1983;38(12):1179-82. ... administration. Based on the one-compartment model data, intravenous administration displayed first-order elimination while ... A comparison of two different doses of rectal ketamine added to 0.5 mg kg-1 midazolam and 0.02 mg kg-1 atropine in infants and ...
Colon and Rectal Cancer | UC San Francisco
Topical Promethazine Side Effects: Our Experience and Review of the Literature
Following rectal administration of promethazine in a suppository formulation, peak plasma concentrations were observed after ... and intravenous routes of administration are more likely to cause allergic drug reactions than oral administration, while ... Administration of activated charcoal would be preferred. The use of a cathartic is no longer recommended. In the absence of ... The elimination half-life of promethazine following oral administration has been estimated to be within the range of 12 to 15 ...
Prevention of Perinatal Group B Streptococcal Disease
Rectal colonization with group B Streptococcus: relation to vaginal colonization of pregnant women. J Infect Dis 1977;135:308-- ... Colombo DF, Lew JL, Pedersen CA, Johnson JR, Fan-Havard P. Optimal timing of ampicillin administration to pregnant women for ... Negative vaginal and rectal GBS screening culture in late gestation† during the current pregnancy, regardless of intrapartum ... Before the inoculation step, laboratories may choose to roll the vaginal-rectal swab(s) on a blood agar plate with or without ...
Enema Uses and Benefits
Rectal Enema: Colon Cleansing, Colitis and Risks. Enemas are used as a laxative; instead of an oral administration it is ... Enemas have to be administrated carefully as there are risks of the rectal tissue or bowel rupturing. Even slight tears are ... Enemas are not advisable for people who have had bowel surgery, hemorrhoids or tumors in the rectal area. ...
Enema Administration: Purpose, Procedure, and Risks
Enema administration is a technique used to stimulate stool evacuation. It is a liquid treatment most commonly used to help ... Blood that is present in the stool after the enema may mean there is rectal damage or an underlying medical problem. Consult ... Enema administration. An enema administration is a technique used to stimulate stool evacuation. It is a liquid treatment most ... Potential risks of enema administration. When conducted properly following a doctors instructions, enema administrations are ...
Ronald Bates Case Study - 1748 Words | Internet Public Library
Red blood cell administration, thawed frozen plasma, and platelets transfusion may be use based on the patient ... Rectal temperature probe for continuous temperature monitoring f. Sedation/ Neuromuscular blockade g. Mechanical ventilator ... Guidelines to follow after opioid administration will vary by hospital but it is still necessary to use sedation scales with ... The recommended door-to-needle time for a patient in need of tissue Plasminogen activator (tPA) administration, for treatment ...
Opiates : Erowid Exp: Main Index
Dr Song's 3D Urology and Prostate Clinics Use High-Grade 3D Self-Administered Rectal Administration Therapy At Home to...
3D Self-administered rectal administration therapy at home. This treatment is usually given to patients at home. Here these ... Dr Songs 3D Urology and Prostate Clinics Use High-Grade 3D Self-Administered Rectal Administration Therapy At Home to ... Dr Songs 3D Urology and Prostate Clinics Use High-Grade 3D Self-Administered Rectal Administration Therapy At Home to ...
DailyMed - FARGELIN HEMORRHOIDAL- calamine, petrolatum and phenylephrine hydrochloride ointment
Diazepam (Rectal)
Step 6: Always keep the tube angled with nozzle downwards during administration. ... Use of diazepam (rectal) with opioids (a group of strong painkillers like morphine and fentanyl) may result in excessive ... Diazepam (rectal) is usually used in the emergency treatment of seizures (fits), including febrile (fever associated) seizures ... Diazepam (rectal) is usually used on a as needed basis to stop a seizure episode. ...
Available Resources | Skyscape
recording drug administration An easy-reference format with clearly worded, bulleted content demonstrated with numerous photos ... calculating oral, topical, liquid, and rectal drug dosages *calculating parenteral injections and IV infusions *calculating ... Provides basic information on the development, administration, and scoring of the NCLEX-PN and how to prepare for and take the ... choosing administration equipment *dealing with poor handwriting *understanding medication labels and drug abbreviations * ...
Oxalobacter formigenes-Derived Bioactive Factors Stimulate Oxalate Transport by Intestinal Epithelial Cells | American Society...
Rectal Administration of O. formigenes OM or CM. O. formigenes OM or CM was administered to PH1 mice as rectal enemas (100 µl ... In a mouse model of primary hyperoxaluria type 1, rectal administration of O. formigenes CM significantly reduced (,32.5%) ... The PH1 mice were given the CM or OM (100 µl twice daily as rectal enemas × 21 days; n=6-8) and urine was collected before ( ... 100 µl twice daily as rectal enemas × 21 days) and urine was collected before (Before Rx) and after treatment (After Rx) for ...
Erowid.org: Erowid Reference 9081 : An Internet Study of User's Experiences of the Synthetic Cathinone 4-Methylethcathinone (4...
Oral, nasal, injecting, eyeball, and rectal routes of administration were described. Testing for purity, allergy testing, and ... Routes of administration, gauging of dosage, and consumption of other drugs; Time course effects and outcomes; and Comparisons ... routes of administration, dosage, positive and undesirable effects, and comparisons to mephedrone. Twenty-three individual, ...
IntravenousAdvanced rectal cancerSuppositoriesEnemaTOPICALBioavailabilityRectumSuppositoryIntramuscularAbsorptionSublingualTemperatureParenteral administrationColon and Rectal CancerRoutes of administratSurgeryUceris Rectal FoamUlcerativeCancerRouteCatheterSwabsProlapseNeoplasmsBowelAdministerHydrocortisonePharmacokineticSuspensionAnalOral and rectalMedicationsFoamInstillationPatientsBudesonide2018ChemotherapyPharmacokineticsBlood vesselsTherapeuticDoseSystemicMorphineEfficacyHemorrhoidsStomachDiseasesBacteriotherapyEnemasDrugsDOSAGE AND ADMINISTRATIONMetastasesClinicalPhysicianDiastatSodiumTissueMedication administrationMucosaViscousDrugCapsules
Intravenous14
- Unlike intravenous lines, which usually need to be placed in an inpatient environment and require special formulation of sterile medications, a specialized rectal catheter can be placed by a clinician, such as a hospice nurse or home health nurse, in the home. (wikipedia.org)
- Because using the rectal route enables a rapid, safe, and lower cost alternative to administration of medications, it may also facilitate the care of patients in long-term care or palliative care, or as an alternative to intravenous or subcutaneous medication delivery in other instances. (wikipedia.org)
- OBJECTIVE: To compare the efficacy and safety of rectal artemether with intravenous quinine in the treatment of cerebral malaria in children. (isharonline.org)
- Elsewhere in the broadcast, Maduro applauded two new alleged treatments as "out of sight": "rectal ozone therapy and intravenous ozone therapy. (breitbart.com)
- A new model in a similar population is proposed for intravenous administration. (page-meeting.org)
- Under the direction of a nephrologist, the patient's metabolic abnormalities were corrected to near-normal values with intravenous administration of fluids. (cmaj.ca)
- Medical ozone is an extremely powerful example of this approach and can be applied externally to limbs and wounds as well as internally by intravenous, rectal or vaginal administration. (jamaica-gleaner.com)
- Following a review of 7 randomized studies, investigators concluded that the benzodiazepine midazolam, administered intranasally, is as safe and effective as intravenous or rectal diazepam in the treatment of acute pediatric seizure emergencies. (medscape.com)
- Results were based on the administration of 0.2 mg/kg of intranasal midazolam versus 0.2-0.5 mg/kg of either intravenous (4 trials) or rectal (3 trials) diazepam, for the treatment of seizure emergencies having an onset of action of less than 5 minutes. (medscape.com)
- ANESTHESIOLOGISTS have focused considerable interest on the propriety of intravenous glucose administration in pediatric surgery. (asahq.org)
- 5 , 6 These phenomena in rats are mimicked by intracerebroventricular 6-9 or intravenous 9 administration of corticotropin releasing hormone (CRH) and are blocked by the CRH antagonist, α helical CRH 9-41 . (bmj.com)
- 10 Furthermore, intravenous administration of CRH decreases slow wave sleep in humans. (bmj.com)
- The purpose of this study was to determine whether intravenous administration of CRH affects human gastrointestinal motility and whether CRH discriminates physiological responses in normal control subjects from those in IBS patients. (bmj.com)
- Analgesic effects of piritramide in acute postoperative pain - comparison of intramuscular administration with patient-controlled intravenous analgesia and impact of OPRM1 and ABCB1 polymorphisms. (cdc.gov)
Advanced rectal cancer5
- Treatment for locally advanced rectal cancer (LARC) consists of chemoradiation therapy (CRT) and surgery. (biomedcentral.com)
- Rectal cancers are treated by surgery, preceded by chemoradiation in case of locally advanced rectal cancer (LARC). (biomedcentral.com)
- The study focused on the cancer drug Jemperli, made by GSK, and involved 13 participants with locally advanced rectal cancer. (zmescience.com)
- The paper "D-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer" has been published in The New England Journal of Medicine . (zmescience.com)
- The standard treatment for locally advanced rectal cancer involves chemotherapy and radiation, known as 5FUCMT, (the chemotherapy drugs 5-fluorouracil/capecitabine and radiation therapy) prior to surgery. (mayoclinic.org)
Suppositories10
- Women used other dosage forms such as lozenges, suppositories, creams, gels, and rectal solutions to address breakthrough symptoms and administer the amount of progesterone needed for symptom relief. (worldhealth.net)
- Hydrocortisone rectal comes as a cream, an enema, suppositories, and a foam to use in the rectum. (epnet.com)
- Hydrocortisone rectal suppositories may stain clothing and other fabrics. (epnet.com)
- Rectal suppositories of medicine have been used for centuries, and more recently it's come to my attention that essential oils can be administered systemically via this technique. (cfnaturalhealth.com)
- Thus, it was suggested to me that I try another route of essential oil administration which would facilitate the delivery of essential oils throughout the entire body by a method that would not harm sensitive lungs: rectal suppositories. (cfnaturalhealth.com)
- I have assisted several clients with the administration of rectal suppositories, and one client who could not tolerate nebulizing essential oils found rectal suppositories very effective at combatting her chronic drug-resistant lung infections. (cfnaturalhealth.com)
- rectal steroid preparations, eg hydrocortisone or prednisolone foam enema, or prednisolone suppositories. (gpnotebook.com)
- The therapeutic course in rectal suppositories lasts from 5 to 10 days. (predstavit-official.com)
- The drug is available in Prostatitis hepatitis S form of tablets for oral administration and suppositories for rectal use. (blokkoldas.hu)
- Artemisinin-based suppositories : use of rectal artemisinin-based suppositories in the management of severe malaria : report of a WHO informal consultation, 27-28 March 2006. (who.int)
Enema11
- Enema Rectal discharge Routes of administration Suppository The rectum has numerous blood vessels available to absorb drugs. (wikipedia.org)
- Rectal bacteriotherapy was applied by enema on three consecutive days and FMT by enema once with possible repetition for two to three infusions within 14 days. (medscape.com)
- An enema administration is a technique used to stimulate stool evacuation. (healthline.com)
- What is an enema administration used for? (healthline.com)
- An enema administration is most commonly used to clean the lower bowel. (healthline.com)
- In some cases, laxatives are used the night before an enema administration to encourage waste flow. (healthline.com)
- Hydrocortisone Rectal Suspension, USP is a convenient disposable single-dose hydrocortisone enema designed for ease of self-administration. (nih.gov)
- Damage to the rectal wall can result from careless or improper insertion of an enema tip. (nih.gov)
- For ulcerative colitis, hydrocortisone rectal enema usually is used every night for 21 days. (epnet.com)
- Evacuation usually comes 15 30 min after administration of glycerin rectal suppository or enema. (medpill.info)
- Success with a rectal enema regimen, but now unable to tolerate rectal administration. (acco.be)
TOPICAL1
- The topical administration of drugs allows targeted care of dermatological or loco-regional pathologies, or by transdermal route. (seppic.com)
Bioavailability3
- A drug that is administered rectally will in general (depending on the drug) have a faster onset, higher bioavailability, shorter peak, and shorter duration than oral administration. (wikipedia.org)
- Absorption rate and bioavailability of phenobarbital and its sodium salt from rectal dosage forms. (wikipedia.org)
- The new training video covers rectal bioavailability, the efficacy of administering rectal medications via the Macy Catheter, rectal catheter procedure, introducing the rectal route to patients and families, monitoring utilization and feedback, and accessing Macy Catheter resources. (fortuneoutlook.com)
Rectum9
- Rectal administration uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels, and flow into the body's circulatory system, which distributes the drug to the body's organs and bodily systems. (wikipedia.org)
- Rectal administration of medication may be performed with any of the following: A suppository, a solid drug delivery system inserted into the rectum where dissolves or melts to exert local or systemic effects. (wikipedia.org)
- A specialized catheter designed for rectal administration of medications and liquids, that can be placed safely and remain comfortably in the rectum for repeated use. (wikipedia.org)
- instead of an oral administration it is directly administered to the rectum and from there to the colon. (yogawiz.com)
- Rectal hydrocortisone is used along with other medications to treat proctitis (swelling in the rectum) and ulcerative colitis (a condition which causes swelling and sores in the lining of the large intestine and rectum). (epnet.com)
- SpaceOAR hydrogel is the first absorbable spacer designed to separate the rectum and prostate to reduce the risk of rectal toxicity during radiotherapy. (businesswire.com)
- SpaceOAR hydrogel is intended to temporarily position the anterior rectal wall away from the prostate during radiotherapy for prostate cancer and in creating this space, SpaceOAR hydrogel reduces the radiation dose delivered to the anterior rectum. (businesswire.com)
- UCERIS ® (budesonide) rectal foam is a prescription corticosteroid medicine used to help get active, mild to moderate ulcerative colitis that extends from the rectum to the sigmoid colon under control (induce remission). (ucerisfoam.com)
- For some individuals, the lesions may not be overtly visible (such as within the oral cavity or within the rectum), therefore clinicians should perform a thorough evaluation including a full body skin, oral, genital, and rectal examination to identify appropriate lesions for sampling. (cdc.gov)
Suppository3
- Doses for Sustanon 250 are administered by injection, oral fluid, or rectal suppository. (sdcss.net)
- It is necessary to lay a suppository with rectal administration 10 cm deep, with vaginal administration - 3-4 cm. (kalinka-store.com)
- Ensure that suppository is inserted beyond rectal sphincter. (medpill.info)
Intramuscular3
- Its available in oral, subcutaneous, intramuscular and rectal forms. (sanpatrignano.org)
- Time of achievement of equilibrium concentration (Css) at parenteral administration - 24 h when assigning 4 times a day (above subtherapeutic) also is at intramuscular introduction 15 mg - 0.5-1 mkg/ml, 30 mg - 1-2.5 mkg/ml. (rxeli.com)
- Parenteral administration refers to any routes of administration that do not contain drug absorption by way of the GI tract (par = around, enteral = gastrointestinal), adding the IV, intramuscular (IM), subcutaneous (SC or SQ), and transdermal routes . (lemonberrymoon.com)
Absorption3
- Absorption studies in ulcerative colitis patients have shown up to 50% absorption of hydrocortisone administered as Hydrocortisone Rectal Suspension, USP and up to 30% of hydrocortisone acetate administered in an identical vehicle. (nih.gov)
- PENTASA® rectal suspensions are designed to provide the distal part of the intestinal tract with high concentrations of mesalazine and a low systemic absorption. (canadapharmacy.com)
- Schematic of pharmacokinetics and absorption, distribution, metabolism, and excretion concept (A), and same schematic highlighting interplay between free and bound drug, and pathway from site of administration to site of action (B). (snmjournals.org)
Sublingual1
- Furthermore, these adverse effects of misoprostol were found to be more with sublingual administration than in rectal [10]. (scirp.org)
Temperature8
- I have read the rectal temperature is accurate best for medical conditions as such likely, M.S or Stroke and other medical. (statnews.com)
- Rectal temperature probe for continuous temperature monitoring f. (ipl.org)
- Ground reaction forces, clinical lameness scores, and rectal temperature were assessed before the injection (baseline) and at various points afterward. (avma.org)
- High rectal temperature is an adverse effect of oral ABT-116 administration that may be of clinical concern. (avma.org)
- Rectal temperature was monitored before, during, and after PH. (researchsquare.com)
- Physiologic data collected during anesthesia included heart and respiratory rate, pulse oximetry, and rectal temperature at various time intervals. (vin.com)
- A rectal temperature is strongly advised, as is evaluation of the robustness of the jugular veins. (vin.com)
- The most popular is rectal temperature and visual indications. (msstate.edu)
Parenteral administration2
- Absorbed in varying degrees following oral, rectal or parenteral administration. (drugbank.com)
- What are the 4 routes of parenteral administration? (lemonberrymoon.com)
Colon and Rectal Cancer1
- Although dependant on retrospective data, the American Joint Committee on Cancer in addition to a National Cancer Institute-sponsored panel have recommended that at least 12 lymph nodes be examined in patients with colon and rectal cancer to substantiate the lack of nodal involvement through the tumor. (laparoscopyhospital.com)
Routes of administrat2
- The study aimed to present user experiences of 4-MEC as reported on the Internet, with a focus on user profiles, sourcing and product characteristics, routes of administration, dosage, positive and undesirable effects, and comparisons to mephedrone. (erowid.org)
- To express the DDD several abbreviations are used for units and routes of administration. (whocc.no)
Surgery9
- Enemas are not advisable for people who have had bowel surgery, hemorrhoids or tumors in the rectal area. (yogawiz.com)
- Retrospective research has revealed that this level of lymph nodes examined in colon and rectal surgery could possibly be linked to therapeutic outcome. (laparoscopyhospital.com)
- In addition to determining the intent of rectal cancer surgery (i.e., curative or palliative), you should consider therapeutic the whole process of the constant maintenance or restoration of normal anal sphincter, genitourinary, and sexual functions. (laparoscopyhospital.com)
- IHA has an excellent full-time employment opportunity for a Board Certified or Board Eligible Colon and Rectal Surgery physician to join a well-established group practice located in southeast Michigan. (leadingagetexas.org)
- This is an exciting opportunity for the right Colon and Rectal Surgery physician to be part of a well-established group practice. (leadingagetexas.org)
- Carle is seeking a Nurse Practitioner/Physician Assistant to join our Colon and Rectal Surgery team. (scasca.org)
- Although radiation therapy to the pelvis has been a standard and important part of treatment for rectal cancer and has been shown to decrease the risk of the cancer coming back in the same area in the pelvis, some patients experience undesirable side effects from the radiation and there have been important advances in chemotherapy, surgery, and radiation which may be of benefit. (mayoclinic.org)
- Complications are inherent to rectal cancer surgery. (umn.edu)
- Raskin, ER & Madoff, RD 2015, Complications of rectal cancer surgery . (umn.edu)
Uceris Rectal Foam18
- Now, "the unique delivery system of Uceris rectal foam can help overcome current treatment limitations by reaching the affected area of the distal colon and keeping the medication there long enough to be effective. (hcplive.com)
- Also, significantly more patients treated with UCERIS rectal foam also achieved key secondary outcome measures compared with placebo at six weeks, including a MMDAI endoscopy score of 0 or 1 in 55.6% versus 43.2% in the first trial and 56.0% vs 36.7% in the second trial. (hcplive.com)
- William Sandborn, MD, Chief, Division of Gastroenterology and Director, UCSD IBD Center, University of California San Diego and UC San Diego Health System, and principle investigator of the trials, said these trial results "definitively demonstrated that UCERIS rectal foam is an efficacious and well-tolerated rectal therapy for the induction of remission in patients with mild-to-moderate distal UC. (hcplive.com)
- Treatment with UCERIS rectal foam also led to a rapid response for rectal bleeding that was sustained through the sixth week of the trial. (hcplive.com)
- The UCERIS rectal foam kit is designed for convenient administration. (ucerisfoam.com)
- Download and activate a UCERIS rectal foam Instant Savings Card. (ucerisfoam.com)
- It is not known if UCERIS rectal foam is safe and effective in children. (ucerisfoam.com)
- UCERIS rectal foam is not for everyone. (ucerisfoam.com)
- Before you take UCERIS rectal foam, tell your healthcare provider if you are pregnant or plan to become pregnant. (ucerisfoam.com)
- UCERIS rectal foam can pass into your breast milk and may harm your baby. (ucerisfoam.com)
- You and your healthcare provider should decide if you will use UCERIS rectal foam or breastfeed. (ucerisfoam.com)
- Do not eat grapefruit or drink grapefruit juice while using UCERIS rectal foam. (ucerisfoam.com)
- You should stop using UCERIS rectal foam before preparing for a colonoscopy. (ucerisfoam.com)
- UCERIS rectal foam is a steroid. (ucerisfoam.com)
- Long-time use of UCERIS rectal foam can cause you to have too much glucocorticosteroid medicine in your blood (hypercorticism). (ucerisfoam.com)
- When UCERIS rectal foam is taken for a long period of time, the adrenal glands do not make enough steroid hormones. (ucerisfoam.com)
- UCERIS rectal foam may weaken your immune system. (ucerisfoam.com)
- If you take certain other steroid medicines to treat allergies, switching to UCERIS rectal foam may cause your allergies to come back. (ucerisfoam.com)
Ulcerative3
- Hydrocortisone Rectal Suspension, USP is indicated as adjunctive therapy in the treatment of ulcerative colitis, especially distal forms, including ulcerative proctitis, ulcerative proctosigmoiditis, and left-sided ulcerative colitis. (nih.gov)
- Proctitis from radiation or ulcerative colitis -- 3 g/15 mL rectal suspension once or twice daily. (bionity.com)
- Salix Pharmaceuticals announced today the US Food and Drug Administration (FDA) has extended final approval for Uceris (budesonide) rectal foam for the induction of remission in patients afflicted with active mild-to-moderate distal ulcerative colitis (UC) extending up to 40cm from the anal verge. (hcplive.com)
Cancer26
- 01:56 and rectal cancer in the United States. (yale.edu)
- This study follows the 'cohort multiple randomized controlled trial' (cmRCT) design: rectal cancer patients are included in a prospective cohort that registers clinical baseline, follow-up, survival and QoL data. (biomedcentral.com)
- A study carried out at the Memorial Sloan Kettering Cancer Center reports on some unprecedented results for an anti-rectal-cancer drug candidate: complete remission in all patients enrolled in the trial. (zmescience.com)
- The prostate questions in the Kidney Conditions section (variable name prefix KIQ_P_D) of the Mobile Examination Center (MEC) Interview provide personal interview data on prostate conditions and whether a rectal examination had been done to check for prostate cancer. (cdc.gov)
- Some patients with rectal cancer present to comprehend locally advanced or recurrent illness that is not easily resected. (laparoscopyhospital.com)
- In patients with rectal cancer, the circumferential resection margin (CRM) is an important pathological staging parameter. (laparoscopyhospital.com)
- Treatment Due to increased likelihood of local recurrence plus a poorer overall prognosis, the treating rectal cancer varies somewhat from that relating to colon cancer. (laparoscopyhospital.com)
- Recent clinical data show that SpaceOAR hydrogel helps to significantly reduce the risk of rectal and urinary toxicities and loss of sexual function associated with radiation therapy in the treatment of prostate cancer," said John Pedersen, CEO of Augmenix. (businesswire.com)
- In January 2017, Augmenix announced three-year post-treatment data from a prospective, randomized, multi-center, patient-blinded clinical trial showing that patients treated with SpaceOAR hydrogel prior to prostate cancer radiotherapy demonstrated significant rectal (bowel), urinary, and sexual benefit through three years of follow up 1 . (businesswire.com)
- SpaceOAR hydrogel is licensed in Canada, cleared by the U.S. Food and Drug Administration and is currently being used in the majority of leading cancer centers in the United States. (businesswire.com)
- Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Rectal Cancer - Pipeline Review, H1 2019, provides an overview of the Rectal Cancer (Oncology) pipeline landscape. (drugpipeline.net)
- Rectal cancer affects the lower part of the colon, which connects the large bowel to the anus. (drugpipeline.net)
- The risk factors for developing rectal cancer are increasing age, smoking, family history of colon or rectal cancer, high-fat diet and/or a diet mostly from animal sources and personal or family history of polyps or colorectal cancer. (drugpipeline.net)
- Rectal cancer commonly spreads to organs such as the liver and the lungs. (drugpipeline.net)
- Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Rectal Cancer - Pipeline Review, H1 2019, provides comprehensive information on the therapeutics under development for Rectal Cancer (Oncology), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (drugpipeline.net)
- The Rectal Cancer (Oncology) pipeline guide also reviews of key players involved in therapeutic development for Rectal Cancer and features dormant and discontinued projects. (drugpipeline.net)
- Rectal Cancer (Oncology) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. (drugpipeline.net)
- The pipeline guide provides a snapshot of the global therapeutic landscape of Rectal Cancer (Oncology). (drugpipeline.net)
- The pipeline guide reviews pipeline therapeutics for Rectal Cancer (Oncology) by companies and universities/research institutes based on information derived from company and industry-specific sources. (drugpipeline.net)
- The pipeline guide reviews key companies involved in Rectal Cancer (Oncology) therapeutics and enlists all their major and minor projects. (drugpipeline.net)
- The pipeline guide evaluates Rectal Cancer (Oncology) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. (drugpipeline.net)
- 69 women (30% of patients for the year) were treated for breast cancer, 22 (10%) men were treated for prostate cancer, 37 (16%) patients were treated for lung cancer, 21 (9%) patients were treated for skin cancer, and 13 (6%) patients were treated for colo/rectal cancer. (haysmed.com)
- The drugs in the FOLFOX regimen are all FDA (Food and Drug Administration) approved and have been used routinely to treat patients with advanced colorectal cancer. (mayoclinic.org)
- Kidney metastases from Rectal Cancer (RC) are quite rare. (clinicsinoncology.com)
- Rosati G, Conte F, Siciliano P, Giampaglia M, Bilancia D, Scarano E. Isolated Kidney Metastases from Rectal Cancer: Report of an Unusual Pattern of Recurrence. (clinicsinoncology.com)
- While their risk of all types of cancer was increased, offspring who were exposed to this miscarriage-prevention drug had nearly five times the risk of developing colon and rectal cancers and almost four times the risk of prostate cancer in young adulthood when compared with those whose mothers didn't take this drug. (ahealthyme.com)
Route15
- In addition, the rectal route bypasses around two-thirds of the first-pass metabolism as the rectum's venous drainage is two-thirds systemic (middle and inferior rectal vein) and one-third hepatic portal system (superior rectal vein). (wikipedia.org)
- Finally, rectal administration can allow patients to remain in the home setting when the oral route is compromised. (wikipedia.org)
- The rectal route of administration is useful for patients with any digestive tract motility problem, such as dysphagia, ileus, or bowel obstruction, that would interfere with the progression of the medication through the tract. (wikipedia.org)
- National Hospice and Palliative Care Organization's Facts and Figures: Hospice Care in America, 2013 Edition" (PDF) Archived 2014-05-13 at the Wayback Machine A Quality Improvement Study: Use of a Rectal Medication Administration Device Intervention to manage end-stage symptoms in hospice patients when the oral route fails. (wikipedia.org)
- 7. Verify the resident's name, the medication name, dosage, route of administration and time of administration prior to administering the medication. (collegerecruiter.com)
- A local route of adenovirus administration in mice with experimental colitis induced by the hapten reagent trinitrobenzenesulphonic acid was next evaluated. (bmj.com)
- Alternative route of administration are available. (swallowingdifficulties.com)
- It is an especially effective route of administration for respiratory and gastrointestinal infections. (cfnaturalhealth.com)
- This technique appealed to me because this systemic circulation via the blood is a treatment route most similar to the administration of IV antibiotics, the most effecive tool for combating CF lung infections. (cfnaturalhealth.com)
- Indications the Pain syndrome of strong and moderate expressiveness - injuries, dislocations, stretchings - a toothache - pains in the postoperative period - oncological diseases - myalgias, arthralgias, neuralgia, sciatica, rheumatic diseases the Route of administration and doses Intramusculary (in oil). (rxeli.com)
- The osmotic laxative market can be segmented based on the product type, route of administration, dosage forms, prescription type, distribution channel, and region. (doctobel.com)
- Based on the route of administration oral segment dominates the osmotic laxative market due to ease of administration, high patient compliance and it also encourages bowel movements to relieve constipation. (doctobel.com)
- We have designed 30 drug icons in 6 categories: Dosing Scheule, Dosage, Drugs Storage, Other Remarks and How to Use, Route of Administration. (drugicon.cc)
- The Macy Catheter is an alternative to both the oral route and the parenteral route of medication administration. (fortuneoutlook.com)
- Continue to involve evac experts in exercises and CASEVAC/ en-route care critical task development and training. (prolongedfieldcare.org)
Catheter4
- Many oral forms of medications can be crushed and suspended in water to be given via a rectal catheter. (wikipedia.org)
- Central venous catheter for drug administration c. (ipl.org)
- An IV catheter will allow for IV drug administration which optimizes the drugs' onset of action. (vin.com)
- By enabling efficient palliation, the rectal catheter helps mitigate staffing challenges, reduce costs, and improve quality scores. (fortuneoutlook.com)
Swabs4
- Pharyngeal, nose, and rectal swabs and urine samples were cultured twice weekly. (biomedcentral.com)
- We use bla CTX-M (the most widespread ESBL gene family) and 16S rRNA (a proxy for bacterial load) abundance data from 833 rectal swabs from 133 ESBL-positive patients followed up in a prospective cohort study in three European hospitals. (elifesciences.org)
- First, rectal swabs collected from 133 patients from three European hospitals were analysed to measure the total gut bacteria and the number of genes for ESBL enzymes. (elifesciences.org)
- Rectal swabs, water and food samples were sent to the national reference laboratories. (who.int)
Prolapse2
- The patient's medical history included rectal prolapse of two years' duration and a worsening, clear rectal discharge of four years' duration. (cmaj.ca)
- Ongoing Research on Guda Bhramsha (Partial Rectal Prolapse) at BLDEA'S Shri B.M.Patil Medical College Hospital And Research Centre, Vijayapura, Presented the scientific papers in many national, International seminars and workshops. (globalayurvedaconferences.com)
Neoplasms1
- The instillation or other administration of drugs into the bladder, usually to treat local disease, including neoplasms. (medconditions.net)
Bowel4
- Enemas have to be administrated carefully as there are risks of the rectal tissue or bowel rupturing. (yogawiz.com)
- 8. The rectal suspension should be retained in the bowel. (canadapharmacy.com)
- Testing Diet Intervention Versus Non-Diet Intervention for Management of Bowel Symptoms in Rectal. (cancer.gov)
- The diagnosis of for people lexapro off label come from a health care professional very glad I any rectal bleeding or do not have a bowel Dosage and Administration. (starnews.ca)
Administer2
- 6. To administer the rectal suspension, lie on your left side with the left leg straight and the right leg bent forward for balance. (canadapharmacy.com)
- 3. Administer and document medication administration per physician's orders. (collegerecruiter.com)
Hydrocortisone9
- Hydrocortisone is a naturally occurring glucocorticoid (adrenal corticosteroid) similar to its acetate and sodium hemisuccinate derivatives, is partially absorbed following rectal administration. (nih.gov)
- Hydrocortisone Rectal Suspension, USP provides the potent anti-inflammatory effect of hydrocortisone. (nih.gov)
- Although rectal hydrocortisone, used as recommended for Hydrocortisone Rectal Suspension, USP, has a low incidence of reported adverse reactions, prolonged use presumably may cause systemic reactions associated with oral dosage forms. (nih.gov)
- Use rectal hydrocortisone exactly as directed. (epnet.com)
- For proctitis, hydrocortisone rectal foam usually is used one or two times a day for 2 to 3 weeks, then if necessary, every other day until your condition improves. (epnet.com)
- For hemorrhoids, hydrocortisone rectal cream usually is used in adults and children 12 years and older up to 3 or 4 times daily. (epnet.com)
- Your doctor may change your dose of rectal hydrocortisone during your treatment to be sure that you are always using the lowest dose that works for you. (epnet.com)
- Before using hydrocortisone rectal foam the first time, carefully read the written instructions that come with it. (epnet.com)
- tell your doctor and pharmacist if you are allergic to hydrocortisone, any other medications, or any of the ingredients in rectal hydrocortisone products. (epnet.com)
Pharmacokinetic1
- 1982) "Rectal drug administration: clinical pharmacokinetic considerations. (wikipedia.org)
Suspension4
- A visit to the toilet is recommended before administration of the rectal suspension. (canadapharmacy.com)
- 2. Immediately before use take the rectal suspension bottle out of the aluminium foil pack and shake it well (Figure 1). (canadapharmacy.com)
- Remain relaxed in the administration position for 5-10 minutes or until the urge to pass the rectal suspension has disappeared (Figure 6). (canadapharmacy.com)
- Try to retain the rectal suspension overnight. (canadapharmacy.com)
Anal2
- 11Hemorrhoids occur when a lot of pressure is put on the rectal and anal blood vessels to an extent of interfering with their circulation so they become swollen with blood. (reitstall-wobker.de)
- Hemorrhoids, Anal Fissures, Anal Fistula, Ano-rectal Abscess are well explained in the samhitas. (globalayurvedaconferences.com)
Oral and rectal1
- studying oral and rectal routes. (page-meeting.org)
Medications2
- 8. Rectal Medications Rectal Medications Provide for privacy Explain procedure to client Place client in Sim's position Apply clean gloves Lubricate tip, round end inserted first Encourage client to relax , deep breathe Insert past sphincter, towards umbilicus Have client remain on side at least five mins. (wowslides.com)
- It facilitates quick and effective symptom management via rectal administration of medications and fluids. (fortuneoutlook.com)
Foam1
- Foam spray was developed for optimized in situ gels for site specific action through vaginal or rectal administration. (rsc.org)
Instillation2
- The rats were sacrificed 24 h after rectal instillation and their colon tissues were examined. (greenmedinfo.com)
- Find the definition of Rectal Instillation in Wikipedia. (medconditions.net)
Patients12
- A further 12 patients were given i.v. ARTS (120 mg) at 0 h and rectal DHA (160 mg) 8 h later. (isharonline.org)
- America's Food and Drug Administration (FDA) and Federal Trade Commission have banned the use of ozone therapy for coronavirus patients and warned consumers to avoid any marketing suggesting it is safe. (breitbart.com)
- Nutritional care plays an essential role in patients with abdominal and rectal diseases who need to undergo surgeries. (bangkokhospital.com)
- Sur 275 patients, 72,0 % ont ressenti une douleur postopératoire d'intensité modérée à sévère au repos et 89,3 % en action. (who.int)
- The current study also drew on previous research on the treatment of patients with mismatch repair deficiency with a compound named Keytruda, which has been granted accelerated approval by the Food and Drug Administration in May 2017 as patients with tumors that have spread beyond their original location and have tested positive for MRD. (zmescience.com)
- [ 9 ] Many practitioners have prescribed rectal diazepam for patients with febrile seizures, particularly those with febrile seizures lasting more than 5 minutes. (medscape.com)
- 5 Fluid administration is contraindicated for patients with respiratory distress associated with heart failure. (vin.com)
- For all other patients with respiratory signs, fluid administration is conservative with fluid deficits (dehydration) corrected over a full 24 hours. (vin.com)
- Dosage and administration thallium poisoning the dosage regimen3 of the throat, as a result of mgso7 therapy for severe thrombocytopenia, coagulopathy, and patients older than age 3 years 12. (childbirthsolutions.com)
- During radiotherapy the spacer resulted in a 73.5% reduction in rectal V70 radiation dose and a 49% reduction in median penile bulb radiation dose in patients treated with SpaceOAR hydrogel compared to men who did not receive SpaceOAR hydrogel (Control). (businesswire.com)
- A significantly greater percentage of patients treated with Uceris experienced improvement in rectal bleeding within the first two weeks of treatment. (hcplive.com)
- Does co-administration of paroxetine change oxycodone analgesia: An interaction study in chronic pain patients. (cdc.gov)
Budesonide2
- budesonide rectal, macimorelin. (medscape.com)
- Serious - Use Alternative (1) budesonide rectal, macimorelin. (medscape.com)
20181
- A randomized controlled trial published in 2018 suggested that rectal acetaminophen 10 mg/kg given every 6 hours may prevent febrile seizure recurrence within the same febrile episode. (medscape.com)
Chemotherapy4
- Differences include surgical technique, using radiation therapy, and also the approach to chemotherapy administration. (laparoscopyhospital.com)
- Patient admissions included but were not limited to treatment for disease management, pain control, radiation implant management, and chemotherapy administration. (haysmed.com)
- The administration of third-line chemotherapy plus aflibercept resulted in a dimension reduction of metastases and disappearance of microhematuria. (clinicsinoncology.com)
- Postoperative complications can lead to a delay in adjuvant chemotherapy administration and have been associated with decreased disease-free and overall survival. (umn.edu)
Pharmacokinetics1
- This trial will evaluate the safety, pharmacokinetics and efficacy of ex vivo HIV infection of rectal mucosa by the CCR5 antagonist drug maraviroc (Selzentry) administered to healthy volunteers. (clinicaltrials.gov)
Blood vessels1
- Drugs with poor solubility encounter limited transport during oral administration because of low concentration gradient between the gut and the blood vessels. (intechopen.com)
Therapeutic1
- Benzodiazepine dependence can occur after administration of therapeutic doses for as few as 1 to 2 weeks and withdrawal symptoms may be seen after the discontinuation of therapy. (pdr.net)
Dose1
- On the fourth day after initiation of treatment, synovitis was induced via intra-articular injection of SU 1 hour before administration of the last treatment dose. (avma.org)
Systemic2
- ATG administration could be associated with systemic reaction, including fever and hypotension, comparable to sepsis. (biomedcentral.com)
- The objective of this second initiative is to demonstrate to what extent a systemic immune response against multiple SARS-CoV-2 variants of concern may be generated via an intranasal administration and whether a bona fide mucosal immune response is elicited. (swissbiotech.org)
Morphine4
- Use of diazepam (rectal) with opioids (a group of strong painkillers like morphine and fentanyl) may result in excessive drowsiness, breathing difficulties and in severe cases, coma or death. (healthhub.sg)
- Unlike morphine and herion it can be administered orally (avoiding introvenous use), has a slow elimination , 25-30 hours, and this allows for a single daily administration, while other opiates require repeated daily intakes. (sanpatrignano.org)
- Relationship between anaesthetic death and ASA status, species, age, nature of the procedure, anaesthetic protocol and occurrence of epidural administration of a combination of morphine and bupivacaine were analysed. (nih.gov)
- The nature of the procedure the patient underwent and epidural administration of a combination of morphine and bupivacaine were not correlated with the occurrence of death during anaesthesia. (nih.gov)
Efficacy2
- To compare the efficacy of a 12-strain mixture termed rectal bacteriotherapy with either FMT or vancomycin for recurrent Clostridioides difficile infection (CDI) in an open-label 3-arm randomised controlled trial. (medscape.com)
- The HIV production in ex vivo cultures from the basal and after drug administration will be compared and the results will be expressed as a measure of Maraviroc efficacy. (clinicaltrials.gov)
Hemorrhoids1
- It is also used to relieve itching and swelling from hemorrhoids and other rectal problems. (epnet.com)
Stomach1
- Ex vivo permeability was significantly higher through cornea than stomach and rectal membranes. (rsc.org)
Diseases3
- Sushruta in his Sushruta samhita elaborately explain about the inner rectal diseases. (globalayurvedaconferences.com)
- The concept of Ano-rectal Diseases in Ayurveda gives a new dimension to the Research scholars. (globalayurvedaconferences.com)
- The clinical study on the Ano-rectal Diseases explained in Ayurveda is compared with the concepts of Modern Science which will help us to make out the clear concepts of Ano-rectal Diseases. (globalayurvedaconferences.com)
Bacteriotherapy5
- Before FMT and rectal bacteriotherapy, we pre-treated with vancomycin for 7-14 days. (medscape.com)
- 0.01) or rectal bacteriotherapy (n = 31), 76% vs 52% (OR 3.0 (1.1-8.8), P = 0.04). (medscape.com)
- Rectal bacteriotherapy and vancomycin performed similarly ( P = 0.61). (medscape.com)
- Rectal bacteriotherapy appears as effective as vancomycin but less effective than 1-3 FMTs. (medscape.com)
- Bacterial Mixture vs FMT vs Vancomycin for C. diff Infection Might rectal bacteriotherapy be a safer alternative to fecal microbiota transplantation for recurrent C. difficile infection? (medscape.com)
Enemas1
- and both antegrade and rectal enemas. (acco.be)
Drugs6
- 7(4):285-311 Moolenaar F, Koning B, Huizinga T. (1979) "Biopharmaceutics of rectal administration of drugs in man. (wikipedia.org)
- Allow sufficient washout time of drugs affecting GH growth hormone release before administering prior to administration of macimorelin. (medscape.com)
- Participants in the LTRA group will continue 10 mg of oral montelukast for 8 weeks, and those in the no treatment group will be observed without the administration of any additional drugs. (biomedcentral.com)
- Toward this end, they are seeking the expansion of their scope of practice, via the magic of legislative alchemy , to include the prescription and administration of drugs. (sciencebasedmedicine.org)
- Hypnotics and the drugs that increase drowsiness are excluded, and other drugs with a marked time of administration. (drugicon.cc)
- Excretion rate of amantadine increases rapidly when urine is acidic, administration of urine acidifying drugs may increase elimination of amantadine from the body. (medscape.com)
DOSAGE AND ADMINISTRATION1
- How Are Sustanon 250 Dosage and Administration Determined, sustanon 250 stack3? (sdcss.net)
Metastases2
- Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. (cnr.it)
- We present the case of a 56-year-old man with lung metastases from a rectal adenocarcinoma diagnosed in October 2015. (clinicsinoncology.com)
Clinical1
- However, clinical studies have not demonstrated any benefit from administration of kaolin-pectin. (msdvetmanual.com)
Physician2
- 4. Compare the resident's physician order and the MAR and report any discrepancies to the nurse prior to administration of the medication. (collegerecruiter.com)
- The most frequent reasons for being out of scope were that the physician was retired, deceased, or employed in teaching, research, or administration. (cdc.gov)
Diastat1
- The NDA for the rectal formulation (Diastat) is expected to be filed in 1995. (steroidportal.com)
Sodium2
- Analysis of the patient's rectal effluent showed a sodium level of 118 mmol/L, a potassium level of 24 mmol/L and chloride level of 118 mmol/L. (cmaj.ca)
- The purpose of the present study was to design and develop an experimental porcine model of ARDS by inducing lung injury with intrapulmonary administration of sodium polyacrylate (SPA). (springeropen.com)
Tissue3
- The recommended door-to-needle time for a patient in need of tissue Plasminogen activator (tPA) administration, for treatment of an ischemic stroke, is one hour. (ipl.org)
- Notably, antibody-mediated depletion was limited in rectal tissue and negligible in lymphoid follicles. (jci.org)
- Compounds absorbed through the rectal tissue circulate throughout the body first before being metabolized (and partially deactivated) by the liver and kidneys [1]. (cfnaturalhealth.com)
Medication administration3
- 1. Perform limited medication administration tasks as delegated by a licensed nurse. (collegerecruiter.com)
- Have completed and successfully passed course work in pharmacology, medication administration and fundamentals of nursing. (collegerecruiter.com)
- Caterino JM, Emond JA, Camargo CA Jr. Inappropriate medication administration to the acutely ill elderly: a nationwide emergency department study, 1992-2000. (medscape.com)
Mucosa1
- Ex vivo HIV infectivity in rectal mucosa biopsies and plasma/mucosa MVC levels will be evaluated. (clinicaltrials.gov)
Viscous1
- A viscous solution intended for rectal administration in undergoing investigation. (steroidportal.com)
Drug13
- Training encompassed the monitoring of routes of drug administration, drawing of simulated blood, vital-sign monitoring based on a pharmaceutical universal training model, vital-sign monitoring devices and simulators, and medical emergency education using biological simulators. (ajpe.org)
- Students successfully learned how to monitor routes of drug administration, vital signs, and pathological conditions. (ajpe.org)
- Sucralfate was approved by the Food and Drug Administration (FDA) in 1981. (bionity.com)
- Rectal administration of gelatin powder-filled capsules is not recommended for a variety of reasons, including the tendency for the material to form a bolus, which is expelled before the patient can absorb the drug. (pharmacytimes.com)
- For local numbing and pain control, doctors typically use local anesthetics approved by the U.S. Food and Drug Administration. (hemorrhoidstalk.com)
- The possession or use of a drug, substance, venom, medication, or blood doping agent for which a recognized analytical method to detect and confirm the administration of such substance has not been developed on the premises of a facility under the jurisdiction of the commission is prohibited. (mn.gov)
- Food and Drug Administration and state and local regulatory agencies. (handhelddigitalscanner.com)
- The Food and Drug Administration (FDA) has considered how it might support the scientific rigor of medicinal cannabis claims, and the review of public data regarding safety and abuse potential is ongoing. (koos.org)
- Prevent or relieve headache (from cerebral dehydration) by having patient lie down during and after administration of drug. (medpill.info)
- What are the 10 rights of drug administration? (lemonberrymoon.com)
- What is parenteral path of drug administration? (lemonberrymoon.com)
- U.S. Food & Drug Administration (FDA - Class II. (colonic.net)
- Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. (globalayurvedaconferences.com)
Capsules1
- A literature search performed on the National Library of Medicine Web site revealed essentially no relevant citations relating to rectal administration of medication in gelatin capsules. (pharmacytimes.com)