Federal Government: The level of governmental organization and function at the national or country-wide level.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Indenes: A family of fused-ring hydrocarbons isolated from coal tar that act as intermediates in various chemical reactions and are used in the production of coumarone-indene resins.Government: The complex of political institutions, laws, and customs through which the function of governing is carried out in a specific political unit.United StatesGovernment Regulation: Exercise of governmental authority to control conduct.Financing, Government: Federal, state, or local government organized methods of financial assistance.Oligopeptides: Peptides composed of between two and twelve amino acids.United States Government Agencies: Agencies of the FEDERAL GOVERNMENT of the United States.Government Agencies: Administrative units of government responsible for policy making and management of governmental activities.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Tablets, Enteric-Coated: Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Excipients: Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.Drug Compounding: The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.Biological Availability: The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.Technology, Pharmaceutical: The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.Methylcellulose: Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.Otolaryngology: A surgical specialty concerned with the study and treatment of disorders of the ear, nose, and throat.Netherlands: Country located in EUROPE. It is bordered by the NORTH SEA, BELGIUM, and GERMANY. Constituent areas are Aruba, Curacao, Sint Maarten, formerly included in the NETHERLANDS ANTILLES.Otorhinolaryngologic Diseases: Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases.Pathology, Molecular: A subspecialty of pathology concerned with the molecular basis (e.g., mutations) of various diseases.Otorhinolaryngologic Surgical Procedures: Surgery performed on the ear and its parts, the nose and nasal cavity, or the throat, including surgery of the adenoids, tonsils, pharynx, and trachea.ItalyToxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.Acetylcysteine: The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.Betaherpesvirinae: A subfamily of HERPESVIRIDAE characterized by a relatively long replication cycle. Genera include: CYTOMEGALOVIRUS; MUROMEGALOVIRUS; and ROSEOLOVIRUS.Meat Products: Articles of food which are derived by a process of manufacture from any portion of carcasses of any animal used for food (e.g., head cheese, sausage, scrapple).Egg Yolk: Cytoplasm stored in an egg that contains nutritional reserves for the developing embryo. It is rich in polysaccharides, lipids, and proteins.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Chickens: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Epitopes: Sites on an antigen that interact with specific antibodies.Yolk Sac: The first of four extra-embryonic membranes to form during EMBRYOGENESIS. In REPTILES and BIRDS, it arises from endoderm and mesoderm to incorporate the EGG YOLK into the DIGESTIVE TRACT for nourishing the embryo. In placental MAMMALS, its nutritional function is vestigial; however, it is the source of INTESTINAL MUCOSA; BLOOD CELLS; and GERM CELLS. It is sometimes called the vitelline sac, which should not be confused with the VITELLINE MEMBRANE of the egg.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Immunoglobulins: Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.
(1/15664) The bioavailability, dispostion kinetics and dosage of sulphadimethoxine in dogs.

The disposition kinetics of sulphadimethoxine were studied in six normal beagle dogs after intravenous injection of a single dose (55 mg/kg). The median (range) distribution and elimination half times of the drug were 2.36 (2.06-3.35) hours and 13.10 (9.71-16.50) hours, respectively. Total body clearance of the drug had a median value of 21.7 ml/kg/h and a mean value of 21.4 ml/kg/h. While the overall tissue to plasma level ratio (k12/k21) of the drug was 0.55 after distribution equilibrium had been attained, analogue computer simulated curves showed that at 24 hours the fractions (percentage) of the dose in the central and tissue compartments were 12 and 11%, respectively. The drug was shown, by equilibrium dialysis method, to be highly bound to plasma proteins (greater than 75%) within the usual therapeutic range (50 to 150 mug/ml) of plasma levels. The systemic availability of sulphadimethoxine from the oral suspension was 32.8% (22.5-80.0). Since the absorption half time, 1.87 (0.86-3.22) hours, was considerably shorter than the half-life, 13.10 (9.71-16.50) hours, of the drug, the rate of absorption would have little influence on the dosage regimen. Based on the experimental data obtained, a satisfactory dosage regimen might consist of a priming dose of 55 mg/kg by the intravenous route and maintenance doses of either 27.5 mg/kg of sulphadimethoxine injection given intravenously or 55 mg/kg of the oral suspension administered at 24 hour intervals. The adequacy and duration of therapy will depend upon the clinical response obtained.  (+info)

(2/15664) Relative efficacy of 32P and 89Sr in palliation in skeletal metastases.

32p and 89Sr have been shown to produce significant pain relief in patients with skeletal metastases from advanced cancer. Clinically significant pancytopenia has not been reported in doses up to 12 mCi (444 MBq) of either radionuclide. To date, no reports comparing the relative efficacy and toxicity of the two radionuclides in comparable patient populations have been available. Although a cure has not been reported, both treatments have achieved substantial pain relief. However, several studies have used semiquantitative measures such as "slight," "fair," "partial" and "dramatic" responses, which lend themselves to subjective bias. This report examines the responses to treatment with 32P or 89Sr by attempting a quantification of pain relief and quality of life using the patients as their own controls and compares toxicity in terms of hematological parameters. METHODS: Thirty-one patients with skeletal metastases were treated for pain relief with either 32P (16 patients) or 89Sr (15 patients). Inclusion criteria were pain from bone scan-positive sites above a subjective score of 5 of 10 despite analgesic therapy with narcotic or non-narcotic medication, limitation of movement related to the performance of routine daily activity and a predicted life expectancy of at least 4 mo. The patients had not had chemotherapy or radiotherapy during the previous 6 wk and had normal serum creatinine, white cell and platelet counts. 32P was given orally as a 12 mCi dose, and 89Sr was given intravenously as a 4 mCi (148 MBq) dose. The patients were monitored for 4 mo. RESULTS: Complete absence of pain was seen in 7 of 16 patients who were given 32P and in 7 of 15 patients who were given 89Sr. Pain scores fell by at least 50% of the pretreatment score in 14 of 16 patients who were given 32P and 14 of 15 patients who were given 89Sr. Mean duration of pain relief was 9.6 wk with 32P and 10 wk with 89Sr. Analgesic scores fell along with the drop in pain scores. A fall in total white cell, absolute granulocyte and platelet counts occurred in all patients. Subnormal values of white cells and platelets were seen in 5 and 7 patients, respectively, with 32P, and in 0 and 4 patients, respectively, after 89Sr therapy. The decrease in platelet count (but not absolute granulocyte count) was statistically significant when 32P patients were compared with 89Sr patients. However, in no instance did the fall in blood counts require treatment. Absolute granulocyte counts did not fall below 1000 in any patient. There was no significant difference between the two treatments in terms of either efficacy or toxicity. CONCLUSION: No justification has been found in this study for the recommendation of 89Sr over the considerably less expensive oral 32P for the palliation of skeletal pain from metastases of advanced cancer.  (+info)

(3/15664) Segmental colonic transit after oral 67Ga-citrate in healthy subjects and those with chronic idiopathic constipation.

Measurement of segmental colonic transit is important in the assessment of patients with severe constipation. 111In-diethylenetriamine pentaacetic acid (DTPA) has been established as the tracer of choice for these studies, but it is expensive and not readily available. 67Ga-citrate is an inexpensive tracer and when given orally is not absorbed from the bowel. It was compared with 111In-DTPA in colonic transit studies in nonconstipated control subjects and then in patients with idiopathic constipation. METHODS: Studies were performed after oral administration of 3 MBq (81 microCi) 67Ga-citrate or 4 MBq (108 microCi) 111In-DTPA in solution. Serial abdominal images were performed up to 96 h postinjection, and computer data were generated from geometric mean images of segmental retention of tracer, mean activity profiles and a colonic tracer half-clearance time. RESULTS: There were no differences in segmental retention of either tracer or in mean activity profiles between control subjects and constipated patients. Results in constipated subjects were significantly different from those in controls. The mean half-clearance times of tracer for control subjects were 28.8 h for 67Ga-citrate and 29.9 h for 111In-DTPA in control subjects and 75.0 h for 67Ga-citrate and 70.8 h for 111In-DTPA in constipated patients. CONCLUSION: Oral 67Ga-citrate can be used as a safe alternative to 111In-DTPA for accurate measurement of segmental colonic transit.  (+info)

(4/15664) Marimastat in recurrent colorectal cancer: exploratory evaluation of biological activity by measurement of carcinoembryonic antigen.

Marimastat is a specific inhibitor of matrix metalloproteinases that has been shown to be effective in cancer models. A pilot, escalating-dose study of oral marimastat was performed in patients with recurrent colorectal cancer, in whom evaluation of serological response was made by measurement of carcinoembryonic antigen (CEA) levels. The study assessed the safety and tolerability of 4 weeks administration of marimastat, and determined a dose range producing detectable serological effects. Patients were recruited with a serum CEA level greater than 5 ng ml(-1), and rising by more than 25% over a 4-week screening period. Patients were treated for 28 days and entered into a continuation protocol if a serological response or clinical benefit was observed. Pharmacokinetic and safety data determined that groups of patients were recruited sequentially at 25 mg and 50 mg twice daily, and, thereafter, 10 mg twice daily, 10 mg once daily, 5 mg once daily and 20 mg once daily. A biological effect (BE) was defined as a CEA value on day 28 no greater than on day 0; a partial biological effect (PBE) was defined as a rise in CEA over the 28-day treatment period of less than 25%. Of 70 patients recruited, 63 completed the 28-day treatment period, and 55 were eligible for cancer antigen analysis. Examination of the dose-effect relationships provides evidence for a causal relationship between marimastat and biological effects: the proportion of patients with BE or PBE was higher with twice daily dosing (16 out of 25, 64%) than with once daily dosing (11 out of 30, 37%) (P = 0.043, chi2 test). Furthermore, the median rates of rise of CEA fell markedly during treatment compared with the screening period for patients receiving twice daily marimastat (P<0.0001), but not for patients receiving marimastat once daily (P = 0.25). Musculoskeletal adverse events emerged as the principal drug-related toxicity of marimastat, occurring in a dose- and time-dependent fashion. It was concluded that marimastat was associated with dose-dependent biological effects in cancer patients. The occurrence of musculoskeletal side-effects define 25 mg twice daily as the upper limit of the dose range for continuous use in further studies. Therefore, a dose range of 20 mg once daily to 25 mg twice daily seems appropriate for further studies, which should aim to demonstrate the efficacy of the drug in terms of conventional clinical end points and describe the long-term tolerability of this novel agent.  (+info)

(5/15664) Suppression of atherosclerotic development in Watanabe heritable hyperlipidemic rabbits treated with an oral antiallergic drug, tranilast.

BACKGROUND: Inflammatory and immunological responses of vascular cells have been shown to play a significant role in the progression of atheromatous formation. Tranilast [N-(3,4-dimethoxycinnamoyl) anthranillic acid] inhibits release of cytokines and chemical mediators from various cells, including macrophages, leading to suppression of inflammatory and immunological responses. This study tested whether tranilast may suppress atheromatous formation in Watanabe heritable hyperlipidemic (WHHL) rabbits. METHODS AND RESULTS: WHHL rabbits (2 months old) were given either 300 mg x kg-1 x d-1 of tranilast (Tranilast, n=12) or vehicle (Control, n=13) PO for 6 months. Tranilast treatment was found to suppress the aortic area covered with plaque. Immunohistochemical analysis showed that there was no difference in the percentage of the RAM11-positive macrophage area and the frequency of CD5-positive cells (T cells) in intimal plaques between Tranilast and Control. Major histocompatibility complex (MHC) class II expression in macrophages and interleukin-2 (IL-2) receptor expression in T cells, as markers of the immunological activation in these cells, was suppressed in atheromatous plaque by tranilast treatment. Flow cytometry analysis of isolated human and rabbit peripheral blood mononuclear cells showed that an increase in expression both of MHC class II antigen on monocytes by incubation with interferon-gamma and of IL-2 receptor on T cells by IL-2 was suppressed by the combined incubation with tranilast. CONCLUSIONS: The results indicate that tranilast suppresses atherosclerotic development partly through direct inhibition of immunological activation of monocytes/macrophages and T cells in the atheromatous plaque.  (+info)

(6/15664) Absorption, metabolism, and excretion of 14C-temozolomide following oral administration to patients with advanced cancer.

The purpose of this study is to characterize the absorption, metabolism, and excretion of carbon 14-labeled temozolomide (14C-TMZ) administered p.o. to adult patients with advanced solid malignancies. On day 1 of cycle 1, six patients received a single oral 200-mg dose of 14C-TMZ (70.2 microCi). Whole blood, plasma, urine, and feces were collected from days 1-8 and on day 14 of cycle 1. Total radioactivity was measured in all samples. TMZ, 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC), and 4-amino-5-imidazole-carboxamide (AIC) concentrations were determined in plasma, and urine and plasma samples were profiled for metabolite/degradation products. Maximum TMZ plasma concentrations were achieved between 0.33 to 2 h (mean, 1.2 h), and half-life, apparent volume of distribution, and oral clearance values averaged 1.9 h, 17 liters/m2, and 104 ml/min/m2, respectively. A first-order absorption, one-compartment linear model, which included first-order formation of MTIC from TMZ and elimination of MTIC via degradation to AIC, and a peripheral distribution compartment for AIC, adequately described the plasma TMZ, MTIC, and AIC concentrations. MTIC systemic clearance was estimated to be 5384 ml/min/m2, and the half-life was calculated to be 2.5 min. Metabolite profiles of plasma at 1 and 4 h after treatment showed that 14C-derived radioactivity was primarily associated with TMZ, and a smaller amount was attributed to AIC. Profiles of urine samples from 0-24 h revealed that 14C-TMZ-derived urinary radioactivity was primarily associated with unchanged drug (5.6%), AIC (12%), or 3-methyl-2,3-dihydro-4-oxoimidazo[5,1-d]tetrazine-8-carboxyl ic acid (2.3%). The recovered radioactive dose (39%) was principally eliminated in the urine (38%), and a small amount (0.8%) was excreted in the feces. TMZ exhibits rapid oral absorption and high systemic availability. The primary elimination pathway for TMZ is by pH-dependent degradation to MTIC and further degradation to AIC. Incomplete recovery of radioactivity may be explained by the incorporation of AIC into nucleic acids.  (+info)

(7/15664) Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. The NNIPS-2 Study Group.

OBJECTIVE: To assess the impact on mortality related to pregnancy of supplementing women of reproductive age each week with a recommended dietary allowance of vitamin A, either preformed or as beta carotene. DESIGN: Double blind, cluster randomised, placebo controlled field trial. SETTING: Rural southeast central plains of Nepal (Sarlahi district). SUBJECTS: 44 646 married women, of whom 20 119 became pregnant 22 189 times. INTERVENTION: 270 wards randomised to 3 groups of 90 each for women to receive weekly a single oral supplement of placebo, vitamin A (7000 micrograms retinol equivalents) or beta carotene (42 mg, or 7000 micrograms retinol equivalents) for over 31/2 years. MAIN OUTCOME MEASURES: All cause mortality in women during pregnancy up to 12 weeks post partum (pregnancy related mortality) and mortality during pregnancy to 6 weeks postpartum, excluding deaths apparently related to injury (maternal mortality). RESULTS: Mortality related to pregnancy in the placebo, vitamin A, and beta carotene groups was 704, 426, and 361 deaths per 100 000 pregnancies, yielding relative risks (95% confidence intervals) of 0. 60 (0.37 to 0.97) and 0.51 (0.30 to 0.86). This represented reductions of 40% (P<0.04) and 49% (P<0.01) among those who received vitamin A and beta carotene. Combined, vitamin A or beta carotene lowered mortality by 44% (0.56 (0.37 to 0.84), P<0.005) and reduced the maternal mortality ratio from 645 to 385 deaths per 100 000 live births, or by 40% (P<0.02). Differences in cause of death could not be reliably distinguished between supplemented and placebo groups. CONCLUSION: Supplementation of women with either vitamin A or beta carotene at recommended dietary amounts during childbearing years can lower mortality related to pregnancy in rural, undernourished populations of south Asia.  (+info)

(8/15664) In vivo activities of peptidic prodrugs of novel aminomethyl tetrahydrofuranyl-1 beta-methylcarbapenems.

A series of novel aminomethyl tetrahydrofuranyl (THF)-1 beta-methylcarbapenems which have excellent broad-spectrum antibacterial activities exhibit modest efficacies against acute lethal infections (3.8 mg/kg of body weight against Escherichia coli and 0.9 mg/kg against Staphylococcus aureus) in mice when they are administered orally. In an effort to improve the efficacies of orally administered drugs through enhanced absorption by making use of a peptide-mediated transport system, several different amino acids were added at the aminomethyl THF side chains of the carbapenem molecules. The resulting peptidic prodrugs with L-amino acids demonstrated improved efficacy after oral administration, while the D forms were less active than the parent molecules. After oral administration increased (3 to 10 times) efficacy was exhibited with the alanine-, valine-, isoleucine-, and phenylalanine-substituted prodrugs against acute lethal infections in mice. Median effective doses (ED50s) of < 1 mg/kg against infections caused by S. aureus, E. coli, Enterobacter cloacae, or penicillin-susceptible Streptococcus pneumoniae were obtained after the administration of single oral doses. Several of the peptidic prodrugs were efficacious against Morganella morganii, Serratia marcescens, penicillin-resistant S. pneumoniae, extended-spectrum beta-lactamase-producing Klebsiella pneumoniae, and E. coli infections, with ED50s of 1 to 14 mg/kg by oral administration compared with ED50s of 14 to > 32 mg/kg for the parent molecules. In general, the parent molecules demonstrated greater efficacy than the prodrugs against these same infections when the drugs were administered by the subcutaneous route. The parent molecule was detectable in the sera of mice after oral administration of the peptidic prodrugs.  (+info)

*  Oral administration
... is a route of administration where a substance is taken through the mouth. Per os (P.O.) is sometimes used ... Oral administration is a part of enteral administration, which also includes Buccal, dissolved inside the cheek Sublabial, ... TheFreeDictionary > oral administration of medication Citing: Mosby's Medical Dictionary, 8th edition. 2009. ... "Oral medications". Informed Health Online. Institute for Quality and Efficiency in Health Care. Retrieved 22 June 2013. ...
*  List of University of Kentucky alumni
Eckenhoff, Edward A. (2015). "EDWARD A. ECKENHOFF In First Person: An Oral History" (PDF). Hospital Administration Oral History ...
*  Tactical combat casualty care
TCCC also promotes the early administration oral and intravenous or intramuscular antibiotics. The remainder of TFC care is ... on the battlefield through the administration of Ketamine and/or Oral Tranmuccossal Fentanyl for casualties with moderate to ... Circulation impairment is assessed and managed through the initiation of intravenous access followed up by administration of ... Moderate to Severe Pain and casualty IS NOT in Shock Oral Transmucosal Fentanyl Citrate (OTFC) 800mcg Moderate to Severe Pain ...
*  Etacrynic acid
On oral administration, it produces diarrhea; intestinal bleeding may occur at higher doses. Ethacrynic acid acts by inhibiting ... Last updated February 2005 per FDA site for NDA 016093 injected form and FDA site for NDA 016092 oral form per index here, each ...
*  ACE inhibitor and thiazide combination
They are given by oral administration. Enalapril/hydrochlorothiazide (trade name Enalapril comp), wherein enalapril is the ACE ...
*  Zafirlukast
Tablets are for oral administration only. As a general rule, leukotriene receptor antagonists like zafirlukast are more ... Zafirlukast is rapidly absorbed into the bloodstream following oral administration, reaching peak plasma levels within 3 hours ... The oral absorption (bioavailability) of zafirlukast is decreased by 40% when it is taken with high fat or high protein meals. ... Cmax is the maximum concentration of the drug achieved in the plasma following dose administration and Tmax is the time at ...
*  Anabolic steroid
Oral administration is the most convenient. Testosterone administered by mouth is rapidly absorbed, but it is largely converted ... High doses of oral AAS compounds can cause liver damage. Peliosis hepatis has been increasingly recognised with the use of AAS ... The traditional routes of administration do not have differential effects on the efficacy of the drug. Studies indicate that ... There are four common forms in which AAS are administered: oral pills; injectable steroids; creams/gels for topical application ...
*  Itraconazole
Conventional itraconazole (e.g. Sporanox) has relatively low bioavailability after oral administration, especially when given ... The oral solution is better absorbed. The cyclodextrin contained in the oral solution can cause an osmotic diarrhea, and if ... Composition comprising Itraconazole for oral administration. 2004. Fresh Patents.com. 26 October 2006. Sporanox (Itraconazole ... United States Food and Drug Administration. "Cardiac arrest provoked by itraconazole and amiodarone interaction: a case report ...
*  Pinazepam
... is rapidly absorbed after oral administration. The main active metabolites of pinazepam are depropargylpinazepam (N- ...
*  Glucocorticoid
The data below refer to oral administration. Oral potency may be less than parenteral potency because significant amounts (up ... Then change to oral hydrocortisone or cortisone as a single morning dose, and gradually decrease by 2.5 mg each week. When the ... In much higher doses, oral or inhaled glucocorticoids are used to suppress various allergic, inflammatory, and autoimmune ... Excessive glucocorticoid levels resulting from administration as a drug or hyperadrenocorticism have effects on many systems. ...
*  Microcystin-LR
Even liver lesions were noticed after oral administration. The LD50 for nasal administration is equal to the intraperitoneal ... Mice showed neoplastic liver nodules after 100 oral administrations at 20 μg/kg bodyweight. The nodules observed were up to 5mm ... However, the induction of DNA strand-breaks in lymphocytes has been observed in mice after single oral administration. The ... By the oral route, microcystin-LR displays acute toxicity in rodents. It is apparent that a significant amount of the oral dose ...
*  Cinoxacin
Protein Binding ranges from 60 to 80%. Cinoxacin is rapidly absorbed after oral administration. The presence of food delays ... however this veterinary use was never approved by the United States Food and Drug Administration (FDA). In complicated UTI, the ...
*  Hydroxyprogesterone acetate
However, probably due its high cost and the inconvenience of daily oral administration, the drug was not a market success. It ... It is the purpose of this paper to introduce and describe a new steroid for oral administration, 17-a-hydroxyprogesterone ... In addition, the inconvenience of daily oral administration may have prevented some market acceptance, especially at that cost ... Prodox Tablets ( Upjohn) A new derivative of progesterone for oral administration. Indications: Secondary amenorrhea, ...
*  Dimethisterone
It is the purpose of this paper to introduce and describe a new steroid for oral administration, 17-a-hydroxyprogesterone ... DAVIS ME, WIED GL (1957). "17-alpha-HYDROXYPROGESTERONE acetate; an effective progestational substance on oral administration ... Secrosteron a new oral progestational substance British Drug Houses (South Africa) (Pty.) Ltd., announce the introduction of ... It was introduced in the United States as an oral contraceptive in combination with high doses of ethinylestradiol under the ...
*  Midodrine
After oral administration, midodrine is rapidly absorbed. The plasma levels of the prodrug peak after about half an hour, and ... Midodrine was approved in the United States by the Food and Drug Administration (FDA) in 1996 for the treatment of dysautonomia ... "FDA recommends withdrawal of midodrine". Food and Drug Administration. FDA proposes withdrawal of low blood pressure drug [ ...
*  Armodafinil
... is readily absorbed after oral administration. The absolute oral bioavailability was not determined due to the ... Armodafinil exhibits linear time-independent kinetics following single and multiple oral dose administration. Increase in ... higher following administration of 200 mg Nuvigil than the corresponding value of modafinil following administration of 200 mg ... and was approved by the U.S. Food and Drug Administration (FDA) in June 2007. In 2016, the FDA granted Mylan rights for the ...
*  Nimesulide
... is absorbed rapidly following oral administration. Nimesulide undergoes extensive biotransformation, mainly to 4- ... Nimesulide has never been filed for Food and Drug Administration (FDA) evaluation in the United States, where it is not ...
*  Subacromial bursitis
... oral administration of non-steroidal anti-inflammatory drugs; physical therapy; chiropractic; and local modalities such as ...
*  Wiley protocol
Topical rather than oral administration[self-published source?] The protocol also includes a follow-up program to monitor the ... Hormones are applied transdermally, using an oil-based skin cream for topical administration.[self-published source?] Doses of ...
*  American ginseng
"Degradation of ginsenosides in humans after oral administration". Drug Metabolism and Disposition. 31 (8): 1065-1071. doi: ...
*  Brucellosis
This regimen has the advantage of oral administration. A triple therapy of doxycycline, with rifampin and co-trimoxazole, has ... The gold standard treatment for adults is daily intramuscular injections of streptomycin 1 g for 14 days and oral doxycycline ... whereas the USAAF administration wanted weapons that were deadly. Also, the stability of M114 in storage was too low to allow ...
*  Sublingual administration
... has certain advantages over oral administration. Being more direct, it is often faster,[quantify] and ... This may be a preferred method to simple oral administration, because MAO is known to oxidize many drugs (especially the ... Lozenge-effects a metred and patient-controlled-rate combination of sublingual, buccal, and oral administration, as with the ... Multi-Purpose Tablets-Soluble tablets for either oral or sublingual (or buccal) administration, often also suitable for ...
*  PNU-142633
... is well tolerated after oral administration. Pregenzer, JF; Alberts, GL; Im, WB; Slightom, JL; Ennis, MD; Hoffman, ...
*  Self-microemulsifying drug delivery system
Within the last years SMEDDS were also utilized for the oral administration of biologics. Due to ion pairing with appropriate ... Gibaud, S. P.; Attivi, D. (2012). "Microemulsions for oral administration and their therapeutic applications". Expert Opinion ... for oral administration containing medium and long chain triglycerides". Eur J Pharm Sci. 28 (3): 233-42. doi:10.1016/j.ejps. ... "Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after administration as a medium-chain ...
*  Saquinavir
Gibaud, S. P.; Attivi, D. (2012). "Microemulsions for oral administration and their therapeutic applications". Expert Opinion ... In the clinic, it was found that the oral bioavailability of saquinavir in both formulations significantly increases when ... Saquinavir, in the Invirase formulation, has a low and variable oral bioavailability, when given alone. The Fortovase ... Saquinavir was the first protease inhibitor (and sixth antiretroviral) approved by the Food and Drug Administration (FDA). ...
*  Cervical cancer
Long-term use of oral contraceptives is associated with increased risk of cervical cancer. Women who have used oral ... On June 15, 2006, the US Food and Drug Administration approved the use of a combination of two chemotherapy drugs, hycamtin and ... In 2006, the U.S. Food and Drug Administration (FDA) approved the first preventive HPV vaccine, marketed by Merck & Co. under ... "FDA Approves First Drug Treatment for Late-Stage Cervical Cancer". U.S. Food and Drug Administration. 2006-06-15. Archived from ...
Assessment of Immunomodulatory Activity of the Biofield Energy Treated Novel Herbomineral Formulation After Oral Administration...  Assessment of Immunomodulatory Activity of the Biofield Energy Treated Novel Herbomineral Formulation After Oral Administration...
The results of primary and secondary humoral immune responses after oral administration of test formulation in female Sprague ... Evaluation of Immune Biomarkers After Oral Administration of the Novel Herbomineral Formulation Treated with The Trivedi Effect ... Evaluation of Immunomodulatory Parameters in Female Sprague Dawley Rats after Oral Administration of the Biofield Energy ... Evaluation of Immune Biomarkers After Oral Administration of Biofield Energy Healing Based Herbomineral Formulation in Male ...
more infohttps://www.trivedieffect.com/the-science/biotech/publication/healers-science/nutraceuticals/assessment-of-immunomodulatory-activity-of-the-biofield-energy-treated-novel-herbomineral-formulation-after-oral-administration-in-female-sprague-dawley-rats/
Oral administration - Wikipedia  Oral administration - Wikipedia
Oral administration is a route of administration where a substance is taken through the mouth. Per os (P.O.) is sometimes used ... a b c TheFreeDictionary , oral administration of medication Citing: Mosby's Medical Dictionary, 8th edition. 2009 ... "Oral medications". Informed Health Online. Institute for Quality and Efficiency in Health Care. Retrieved 22 June 2013.. .mw- ... Sublingual administration, dissolved under the tongue, but due to rapid absorption many consider SL a parenteral route ...
more infohttps://en.m.wikipedia.org/wiki/Oral_administration
Oral administration - Wikipedia  Oral administration - Wikipedia
Oral administration is a route of administration where a substance is taken through the mouth. Per os (P.O.) is sometimes used ... Oral administration is a part of enteral administration, which also includes Buccal, dissolved inside the cheek Sublabial, ... TheFreeDictionary > oral administration of medication Citing: Mosby's Medical Dictionary, 8th edition. 2009. ... "Oral medications". Informed Health Online. Institute for Quality and Efficiency in Health Care. Retrieved 22 June 2013. ...
more infohttps://en.wikipedia.org/wiki/Oral_administration
Oral administration of a theraputic drug  Oral administration of a theraputic drug
Does anyone know what CPT code I would use for the administration of a theraputic drug given orally? It is a melt-away tablet ... Does anyone know what CPT code I would use for the administration of a theraputic drug given orally? It is a melt-away tablet ... Drug Administration and Monitoring. By lao1960 in forum Medical Coding General Discussion ...
more infohttps://www.aapc.com/memberarea/forums/46344-oral-administration-theraputic-drug.html
ACY-7 Oral Administration of Acyline - Study Results - ClinicalTrials.gov  ACY-7 Oral Administration of Acyline - Study Results - ClinicalTrials.gov
ACY-7 Oral Administration of Acyline (ACY-7). The safety and scientific validity of this study is the responsibility of the ... Oral Acyline. 20 mg dose of GIPET enhanced oral acyline for 7 days ... Oral Acyline. 20 mg dose of GIPET enhanced oral acyline for 7 days ... Oral testosterone in oil plus dutasteride in men: a pharmacokinetic study. J Clin Endocrinol Metab. 2005 May;90(5):2610-7. Epub ...
more infohttps://clinicaltrials.gov/ct2/show/results/NCT00603187
Bioavailibility of paracetamol after oral administration to healthy volunteers | SpringerLink  Bioavailibility of paracetamol after oral administration to healthy volunteers | SpringerLink
Administration, oral Bioavailability Caffeine Drug therapy, combination Paracetamol Pharmacokinetics This is a preview of ... Eandi M, Viano I, Ricci Gamalero S. Absolute bioavailability of paracetamol after oral and rectal administration in healthy ... Bioavailibility of paracetamol after oral administration to healthy volunteers. Influence of caffeine on rate and extent of ...
more infohttps://link.springer.com/article/10.1007%2FBF01957785
Oral administration legal definition of oral administration  Oral administration legal definition of oral administration
What is oral administration? Meaning of oral administration as a legal term. What does oral administration mean in law? ... Definition of oral administration in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... Related to oral administration: oral administration of medication, inhalation administration Administration. The performance of ... Oral administration legal definition of oral administration https://legal-dictionary.thefreedictionary.com/oral+administration ...
more infohttps://legal-dictionary.thefreedictionary.com/oral+administration
Why cant sensipar tablets be broken in half before oral administration?  Why can't sensipar tablets be broken in half before oral administration?
... oral - Answer: Too much medication would be released at once causing undesirable side ... ... Why can't sensipar tablets be broken in half before oral administration?. Asked. 27 Apr 2016 by Ein. Active. 27 Apr 2016. ... How many 250 mg tablets should you give to equal 1 gram of oral antibiotic?. Posted 10 Jan 2017 • 1 answer ...
more infohttps://www.drugs.com/answers/sensipar-tablets-broken-half-before-oral-3047686.html
US5707353A - Oral administration of beneficial agents 
        - Google Patents  US5707353A - Oral administration of beneficial agents - Google Patents
... a beverage or water and the liquid is contacted with the beneficial agent during or just before oral administration thereof. ... secured therein whereby the beneficial agent is taken up in the liquid for drinking during or just prior to oral administration ... Apparatus for adding a beneficial agent to a liquid for drinking during oral administration includes a support structure ... Oral administration of beneficial agents JP52373397A JPH11502450A (en) 1995-12-21. 1996-12-12. Oral administration of a ...
more infohttps://patents.google.com/patent/US5707353A/en
Longer period of oral administration of aspartame on cytokine  Longer period of oral administration of aspartame on cytokine
... response in Wistar albino rats. ... MATERIALS AND METHODS: The effects of long-term administration of aspartame (40 mg/kg body weight/day) were tested in Wistar ...
more infohttp://www.greenmedinfo.com/article/aspartame-acts-chemical-stressor-because-increased-corticosterone-level-and-in
Lynparza (Olaparib Capsules for Oral Administration): Side Effects, Interactions, Warning, Dosage & Uses  Lynparza (Olaparib Capsules for Oral Administration): Side Effects, Interactions, Warning, Dosage & Uses
Olaparib Capsules for Oral Administration) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling ... oral candidiasis, oral discomfort, oral herpes, oral infection, oral mucosal erythema, oral pain, oropharyngeal discomfort, and ... Lynparza tablets for oral administration contain 100 mg or 150 mg of olaparib. Inactive ingredients in the tablet core are ... Following oral administration of olaparib, absorption is rapid with median peak plasma concentrations typically achieved 1.5 ...
more infohttps://www.rxlist.com/lynparza-drug.htm
Oral administration of encapsulated bovine lactoferrin protein nanocap | IJN  Oral administration of encapsulated bovine lactoferrin protein nanocap | IJN
Oral administration of encapsulated bovine lactoferrin protein nanocapsules against intracellular parasite Toxoplasma gondii ... Oral administration of encapsulated bovine lactoferrin protein nanocapsules against intracellular parasite Toxoplasma gondii. ... Fe metabolism inside the mice has been found to be maintained even after administration of mono form of Lf, this indicates ... Keywords: nanocapsules, oral delivery, cytokines, Toxoplasma gondii, ceramic nanocapsules and reactive oxygen species, ...
more infohttps://www.dovepress.com/oral-administration-of-encapsulated-bovine-lactoferrin-protein-nanocap-peer-reviewed-article-IJN
Zolpidem tartrate tablets for oral administration - Prescription Drugs  Zolpidem tartrate tablets for oral administration - Prescription Drugs
Zolpidem tartrate tablets for oral administration. Home/Zolpidem tartrate tablets for oral administration ... Zolpidem tartrate tablets for oral administrationDmitri Soroka2018-09-06T09:12:40+00:00 ... Zolpidem tartrate tablets are available in 5 mg and 10 mg strength tablets for oral administration.. Zolpidem tartrate tablets ... hypnotic of the imidazopyridine class and is available in 5 mg and 10 mg strength tablets for oral administration.. Chemically ...
more infohttps://www.prescriptiondrugs.com/zolpidem-tartrate-tablets-for-oral-administration/
EP0650730A1 - Rapamycin formulations for oral administration 
        - Google Patents  EP0650730A1 - Rapamycin formulations for oral administration - Google Patents
The present invention comprises novel oral rapamycin formulations which have, per 100 ml of formulation, from about 0.05 to ... EP0650730A1 - Rapamycin formulations for oral administration - Google Patents. Rapamycin formulations for oral administration ... Pharmaceutical preparations comprising cyclosporin for oral administration US5516770A (en) 1996-05-14. Rapamycin formulation ... EP19940307118 1993-09-30 1994-09-29 Rapamycin formulations for oral administration Withdrawn EP0650730A1 (en) Priority ...
more infohttps://patents.google.com/patent/EP0650730A1/en
Pharmacokinetic Alteration of Baclofen by Multiple Oral Administration of Herbal Medicines in Rats  Pharmacokinetic Alteration of Baclofen by Multiple Oral Administration of Herbal Medicines in Rats
of baclofen after oral dosing was calculated as , where was obtained from the previous study [19]. ... After 10 min of the final dose of DW or each herbal medication, baclofen (1 mg/kg) was given by oral administration and plasma ... The absorption process after oral administration of baclofen was described as a first-order rate constant, . The differential ... Plasma baclofen increased rapidly after oral administration, reached its maximum concentration (. ) within 1 hour, and declined ...
more infohttps://www.hindawi.com/journals/ecam/2014/402126/
Solvent for oral administration of test drugs - Animal and Zoology  Solvent for oral administration of test drugs - Animal and Zoology
Solvent for oral administration of test drugs - DW or PBS or Saline (Oct/26/2008 ). Dear friends,. I am planning to do ... We do a lot of oral gavage administration to mice in the context of experimental anticancer therapeutics.. Appropriate volume ... The test compound will be administered orally by using oral gavage. My question is which solvent is best for the oral doses and ... The test compound will be administered orally by using oral gavage. My question is which solvent is best for the oral doses and ...
more infohttp://www.protocol-online.org/biology-forums/posts/40672.html
Furosemide Pharmacodynamics and Pharmacokinetics After Subcutaneous or Oral Administration - Full Text View - ClinicalTrials.gov  Furosemide Pharmacodynamics and Pharmacokinetics After Subcutaneous or Oral Administration - Full Text View - ClinicalTrials.gov
Furosemide Pharmacodynamics and Pharmacokinetics After Subcutaneous or Oral Administration (FUROPHARM-HF). The safety and ... Drug: Furosemide injection solution for subcutaneous administration (80 mg) Drug: Oral Furosemide tablets (80 mg) Phase 1 Phase ... Oral Furosemide tablets (80 mg) followed by Furosemide injection solution for subcutaneous administration (80 mg) over 5 hours ... Drug: Furosemide injection solution for subcutaneous administration (80 mg). Drug: Oral Furosemide tablets (80 mg). ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT02350725
Effects of Oral Administration of N-Acetyl-l-cysteine | Cancer Epidemiology, Biomarkers & Prevention  Effects of Oral Administration of N-Acetyl-l-cysteine | Cancer Epidemiology, Biomarkers & Prevention
Effects of Oral Administration of N-Acetyl-l-cysteine. Frederik Jan Van Schooten, Ahmad Besarati Nia, Silvio De Flora, ... Effects of Oral Administration of N-Acetyl-l-cysteine. Frederik Jan Van Schooten, Ahmad Besarati Nia, Silvio De Flora, ... Effects of Oral Administration of N-Acetyl-l-cysteine. A Multi-Biomarker Study in Smokers. Frederik Jan Van Schooten, Ahmad ... Effects of Oral Administration of N-Acetyl-l-cysteine Message Subject (Your Name) has forwarded a page to you from Cancer ...
more infohttp://cebp.aacrjournals.org/content/11/2/167.long
Effects of Oral Administration of N-Acetyl-l-cysteine | Cancer Epidemiology, Biomarkers & Prevention  Effects of Oral Administration of N-Acetyl-l-cysteine | Cancer Epidemiology, Biomarkers & Prevention
Effects of Oral Administration of N-Acetyl-l-cysteine. Frederik Jan Van Schooten, Ahmad Besarati Nia, Silvio De Flora, ... Effects of Oral Administration of N-Acetyl-l-cysteine. Frederik Jan Van Schooten, Ahmad Besarati Nia, Silvio De Flora, ... Effects of Oral Administration of N-Acetyl-l-cysteine. A Multi-Biomarker Study in Smokers. Frederik Jan Van Schooten, Ahmad ... Effects of Oral Administration of N-Acetyl-l-cysteine Message Subject (Your Name) has forwarded a page to you from Cancer ...
more infohttp://cebp.aacrjournals.org/content/11/2/167.article-info
Tissue Distribution of trans-Resveratrol and Its Metabolites after Oral Administration in Human Eyes  Tissue Distribution of trans-Resveratrol and Its Metabolites after Oral Administration in Human Eyes
... Shuaishuai Wang,1,2 Zheng ... D. Wang, Y. Xu, and W. Liu, "Tissue distribution and excretion of resveratrol in rat after oral administration of Polygonum ... in mouse tissues after oral administration," Life Sciences, vol. 72, no. 20, pp. 2219-2233, 2003. View at Publisher · View at ... T. Walle, F. Hsieh, M. H. DeLegge, J. E. Oatis Jr, and U. K. Walle, "High absorption but very low bioavailability of oral ...
more infohttps://www.hindawi.com/journals/joph/2017/4052094/ref/
  • Select patients with g BRCA m advanced epithelial ovarian, fallopian tube or primary peritoneal cancer for therapy based on an FDA-approved companion diagnostic for Lynparza [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)
  • Select patients for therapy based on an FDA-approved companion diagnostic for Lynparza [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)
  • Oral nasturtium intake resulted in an increased release of PYY over a time period of 6 h whereas circulating levels of other hormones were not changed. (ovid.com)
  • Encompasses the teaching, research, and patient care aspects pertaining to conditions and diseases of oral soft tissues and periodontium. (dmoztools.net)
  • Thapa, I'm not aware of any differences among the three vehicles you mentioned with respect to oral delivery. (protocol-online.org)
  • Oral administration is a route of administration where a substance is taken through the mouth . (wikipedia.org)
  • Higher IPNV uptake by the oral compared to anal route suggests that both the anterior and posterior intestines are important for the uptake of the virus and that IPNV is resistant to gastric degradation of the Atlantic salmon stomach. (mdpi.com)
  • 3. There are several kinds of administrations, besides the usual kind which gives to the administrator the management of all the personal estate of the deceased for an unlimited time. (thefreedictionary.com)
  • This invention relates to formulations containing rapamycin, or pharmaceutically acceptable salts of rapamycin, which are useful in oral administrations for inducing immunosuppression and for treating transplantation rejection, host vs. graft disease, autoimmune diseases, diseases of inflammation, solid tumors, fungal infections, adult T-cell leukemia/lymphomas and hyperproliferative vascular disorders. (google.com)
  • In general the right of administration belongs to him who" has the right to the venue of the personalty: as if A make his will, and appoint B his executor, who dies intestate, and C is the legatee of the residue of A's estate, C has the right of administration cum testamento annexo. (thefreedictionary.com)