The giving of drugs, chemicals, or other substances by mouth.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Injections made into a vein for therapeutic or experimental purposes.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Elements of limited time intervals, contributing to particular results or situations.
Delivery of medications through the nasal mucosa.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Delivery of substances through VENIPUNCTURE into the VEINS.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Injections into the cerebral ventricles.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
The application of suitable drug dosage forms to the skin for either local or systemic effects.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Administration of a soluble dosage form by placement under the tongue.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
The observable response an animal makes to any situation.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
Proteins prepared by recombinant DNA technology.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Introduction of substances into the body using a needle and syringe.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
The measurement of an organ in volume, mass, or heaviness.
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Administration of a drug or chemical by the individual under the direction of a physician. It includes administration clinically or experimentally, by human or animal.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
The physical activity of a human or an animal as a behavioral phenomenon.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Therapy with two or more separate preparations given for a combined effect.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Delivery of drugs into an artery.
Administration of a soluble dosage form between the cheek and gingiva. It may involve direct application of a drug onto the buccal mucosa, as by painting or spraying.
An encapsulated lymphatic organ through which venous blood filters.
A family of hexahydropyridines.
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
Antibodies produced by a single clone of cells.
Uptake of substances through the lining of the INTESTINES.
Glucose in blood.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
The action of a drug in promoting or enhancing the effectiveness of another drug.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
The consumption of edible substances.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Substances that reduce or suppress INFLAMMATION.
Substances that reduce the growth or reproduction of BACTERIA.
A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.
An anti-inflammatory 9-fluoro-glucocorticoid.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
The insertion of drugs into the vagina to treat local infections, neoplasms, or to induce labor. The dosage forms may include medicated pessaries, irrigation fluids, and suppositories.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Refers to animals in the period of time just after birth.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
The measure of the level of heat of a human or animal.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Agents inhibiting the effect of narcotics on the central nervous system.
The rate dynamics in chemical or physical systems.
An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.
A cabinet department in the Executive Branch of the United States Government concerned with overall planning, promoting, and administering programs pertaining to VETERANS. It was established March 15, 1989 as a Cabinet-level position.
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
Use of plants or herbs to treat diseases or to alleviate pain.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
Drugs used to cause dilation of the blood vessels.
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.
Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
The flow of BLOOD through or around an organ or region of the body.
A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
The surgical removal of one or both ovaries.
An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Implanted fluid propulsion systems with self-contained power source for providing long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristatically controlled with the aid of transcutaneous monitoring.
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.
Disease having a short and relatively severe course.
Substances which lower blood glucose levels.
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
A group of compounds that contain the structure SO2NH2.
A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.

Recent advances in ophthalmic drug delivery. (1/59)

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Using fewer animals to identify chemical eye hazards: revised criteria necessary to maintain equivalent hazard classification. (2/59)

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Distribution of propranolol in periocular tissues: a comparison of topical and systemic administration. (3/59)

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The relationship between glaucoma medication adherence, eye drop technique, and visual field defect severity. (4/59)

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Polymeric vectors for ocular gene delivery. (5/59)

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Brimonidine tartrate-eudragit long-acting nanoparticles: formulation, optimization, in vitro and in vivo evaluation. (6/59)

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The effect of dorzolamide 2% on circadian intraocular pressure in cats with primary congenital glaucoma. (7/59)

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Effects of unilateral topical administration of 0.5% tropicamide on anterior segment morphology and intraocular pressure in normal cats and cats with primary congenital glaucoma. (8/59)

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This independent 125 pages report guarantees you will remain better informed than your competition. With over 170 tables and figures examining the Sustained Release Ocular Drug Delivery Systems market, the report gives you a visual, one-stop breakdown of the leading products, submarkets and market leaders market revenue forecasts as well as analysis to 2025.. The report provides a basic overview of the Sustained Release Ocular Drug Delivery Systems industry including definitions, classifications, applications and industry chain structure. And development policies and plans are discussed as well as manufacturing processes and cost structures.. Primary sources are mainly industry experts from core and related industries, and suppliers, manufacturers, distributors, service providers, and organizations related to all segments of the industrys supply chain. The bottom-up approach was used to estimate the Global market size of Sustained Release Ocular Drug Delivery Systems Market based on end-use ...
A multidisciplinary approach is increasingly being adapted by the Pharmaceutical industry to tackle several challenges in developing efficacious treatment solutions. The field of Ophthalmology is no less different. Treatise on Ocular Drug Delivery is a unique collection of information put together by various experts in the field. One of the major goals behind this volume is to link clinical information with the current strategies employed in ocular drug delivery. This monograph covers a range of topics on ocular pharmacology. Chapters in the e-book cover several aspects of drug delivery research such as the biochemical background of specific eye diseases, challenges for ocular drug delivery, the role of influx and efflux transporters, novel drug delivery systems, pharmacokinetics, regulatory aspects, and patenting opportunities for researchers. This E-Book would serve as a suitable reference for pharmacy graduates, medical students, professional scientists and ophthalmic clinicians in academic ...
Various efforts in ocular drug delivery have been made to improve the bioavailability and to prolong the residence time of drugs applied topically onto the eye. . The present presentation includes | Basics of drug delivery systems | General aspects for design and development of DDS | General concepts of ocular drug delivery routes | various pros and cons of ocular drug therapy
Title:Role of Membrane Transporters and Metabolizing Enzymes in Ocular Drug Delivery. VOLUME: 15 ISSUE: 7. Author(s):Ramya Krishna Vadlapatla, Aswani Dutt Vadlapudi, Dhananjay Pal and Ashim K. Mitra. Affiliation:University of Missouri- Kansas City, School of Pharmacy, 2464 Charlotte Street, Kansas City, MO 64108-2718, USA.. Keywords:Age-related eye diseases, drug delivery, membrane transporters, metabolizing enzymes, pharmacodynamic, pharmacokinetic and tissue localization.. Abstract:Ocular disorders can significantly lower a patients quality of life. Centers for Disease Control and Preventions Vision Health Initiative have estimated that the number of people affected by age-related ocular diseases may be doubled in the United States by 2030. Although availability of newer therapeutics has improved the prognosis of ocular diseases, poor ocular bioavailability still remains a major concern. Combinations of pharmacodynamic and pharmacokinetic barriers have been known to determine the amount of ...
This chapter aims to provide the readers a comprehensive review of the current trends and approaches used in the development of ocular drug delivery systems. After the introduction to the topic, the c
Hao, J.; Fang, X.; Zhou, Y.; Wang, J.; Guo, F.; Li, F.; Peng, X., 2011: Development and optimization of solid lipid nanoparticle formulation for ophthalmic delivery of chloramphenicol using a Box-Behnken design
Prostaglandin derivatives, parasympathomimetics, β blockers, and carbonic anhydrase inhibitors are the major drug classes that are used in the management of glaucoma.4,5 Prostaglandin derivatives, such as latanoprost and bimatoprost, increase the aqueous humor (AH) outflow through the uveoscleral pathway. Several mechanisms have been proposed to explain how prostaglandin derivatives reduce the IOP. Relaxation of the ciliary muscles, which causes the connective tissue-filled spaces in the trabecular meshwork to widen, is thought to be a factor that is involved in the initial drop in IOP.6 Prostaglandin analogs also induce the release of matrix metalloproteinase enzymes and cause the dissolution of types I and III collagen within the connective tissue-filled spaces.7 This process also leads to an increase in the AH outflow through the trabecular meshwork. Pilocarpine is a direct-acting cholinergic parasympathomimetic agent. It directly stimulates the muscarinic receptors and smooth muscles of the ...
A topical dose of LE-MPP (35 μL) was administered in the right eye of 5- to 6-month-old female Gottingen mini-pigs (Marshall Farms USA, Inc., North Rose, NY) approximately 6 hours apart (± 20 minutes), for 4 consecutive days. On the fifth day, animals were administered only two doses, approximately 6 hours apart (±20 minutes). A total of 18 doses were administered over the study duration. The dose was administered on the top of the cornea via a calibrated positive displacement micropipette and allowed to distribute across the eye. Each animal was restrained for approximately 1 minute to prevent rubbing of the eyes. Any observed irregularities or local irritation were recorded. Three animals/time point were euthanized with sodium pentobarbital and blood was collected via cardiac puncture at 0.5, 1, and 2 hours after the last dose on day 5. Blood (approximately 10 mL) was collected into tubes containing K2EDTA and samples were maintained on wet ice until centrifuged to obtain plasma. All plasma ...
Severe vision loss from vitreoretinal (VR) diseases such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), intraocular lymphoma (IOL), uveitis and proliferative retinopathy (PVR ) accounts for most cases of irreversible ocular diseases world-wide. Existing therapeutic procedures for treatment of VR diseases are limited as: 1) systemic drug therapy administered through mouth or injected into the bloodstream, and topical administration such as eye drops, fail to penetrate the physiological barriers; 2) intravitreal injections can lead to uneven drug distribution causing increased toxicity for non-target ocular tissues; and 3) in comparison to lipophilic (not water soluble) drugs, sustained release devices for hydrophilic (water soluble) drugs for treating VR diseases are difficult to fabricate, as these hydrophilic drugs do not bind well with existing FDA approved lipophilic materials. At present, research is being conducted in developing a novel polymer-based biodegradable ...
INTRODUCTION: Many macromolecular therapeutics designed to treat posterior segment eye diseases (PSEDs) are administered through frequent ocular injec
H2020,OcuTher,MSCA-ITN-2016,20MED THERAPEUTICS BV(NL),CERTARA UK LIMITED(UK),UNIVERSITE DE STRASBOURG(FR),Vasgen Limited(UK),UNIVERSITA DEGLI STUDI DI PADOVA(IT),Retina International(CH),THE QUEENS UNIVERSITY OF BELFAST(UK),UNIVERSIDAD COMPLUTENSE DE MADRID(ES),DELSITECH OY(FI),OZ BIOSCIENCES SAS(FR),SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH(PL),Bio-Ker s.r.l(IT),INNOCORE TECHNOLOGIES BV(NL),BAYER AKTIENGESELLSCHAFT(DE),UNIVERSITEIT UTRECHT(NL),EBERHARD KARLS UNIVERSITAET TUEBINGEN(DE),TECHNISCHE UNIVERSITEIT EINDHOVEN(NL),ITA-SUOMEN YLIOPISTO(FI)
Authors: Otsuka, Makoto , Nakahigashi, Yoshinori , Matsuda, Yoshihisa , Kokubo, Tadashi , Yoshihara, Satoru , Fujita, Hiroshi , Nakamura, Takashi Article Type: Research Article Abstract: The in vivo and in vitro drug release profiles from a self-setting bioactive CaO-SiO2 -P2 O5 glass bone cement containing indomethacin as a model drug were investigated. The cement containing 2% and 5% indomethacin (IMC) powder hardened within 5 min after mixing with ammonium phosphate buffer. After setting, in vitro drug release from drug-loaded cement pellets in a simulated body fluid (SBF) at pH 7.25 and 37°C continued for two weeks. The hardened cement gradually formed low-crystallinity hydroxyapatite during the drug release test in SBF. An IMC-loaded cement device (2% and 5% drug) was implanted in the subcutaneous tissue …on the back of rats. The in vivo IMC release from the cement increased and attained maximum levels (Cmax of 2% and 5% drug-loaded cements was 0.27 and 3.37 μg/ml, respectively) at Tmax ...
A sympathomimetic with alpha-adrenergic activity. It produces peripheral vasoconstriction and increased blood pressure without stimulating effects on the central nervous system. Used as a decongestant in topical nasal preparations at low concentrations, associated with other drugs, in oral preparations to treat respiratory colds (Nice 2000, Kanfer 1993) and in eye drops at concentrations of up to 10% as a mydriatic. It is also used subcutaneously or intramuscularly in severe hypotensive states and associated with topical anesthetics. Since the last update we have not found published data on its excretion in breastmilk. The low dose of phenylephrine in nasal, ophthalmic and topical preparations makes it unlikely to transfer into breastmilk in significant amounts. It is advised to press on the tear duct after administering eye drops in order to decrease absorption. Low plasma concentrations have been recorded at 10 minutes after ophthalmic administration and practically zero at one hour (AEMPS
Eye drops are the most acceptable dosage form by ocular route, which as has disadvantage of bioavailability. The anatomical and physiological constrains limited permeability of drug such as drug loss from the ocular surface by lachrymal drainage, blood-ocular barriers. A number of drug delivery system has been developed to improve the bioavailability and to prolong the residence time of drugs on the eye. Such as promising system for ocular drug delivery is a microemulsion. Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. This review gives an overview of the potential of microemulsions as delivery vehicles for eye. Both lipophilic and hydrophilic characteristics are present in microemulsions, so that the loaded drugs can diffuse passively as well get significantly partitioned in the variable lipophilic-hydrophilic corneal barrier.
Do all microorganisms look the same? Can they move and change shape? What do they feed on? How small are they . . . and are they actually alive? This activities looks microorganisms under a microscope using the hanging drop technique.
Data Availability StatementAll relevant data are inside the paper. and is also important in the context of numerous applications including, e.g., cells executive, disease modeling and drug screening platforms [1C3]. The structure and size of the related scaffolds vary in a broad range from two-dimensional (2D) arrays of sub-millimeter wells to complex 3D constructions aiming at mimicking specific organs [2, 3]. Chemically, the scaffolds are often fabricated by using natural hydrogels [2], synthetic polymers [1], or combination of such materials [4]. Cells growing in scaffolds typically aggregate. The morphology and form of aggregates could be different, depending on several factors like the cell type, style of a scaffold as well as the matching fabrication materials [1]. Cellular spheroids signify the most frequent form of cell set up [5, 6]. Aggregates of the shape were made, e.g., by concave microwell technique [7], dangling drop technique [5, 8], or rotating-wall vessel technique [9, 10]. The ...
Publications & Citations Citations record http://scholar.google.com/citations?user=f6RQgCAAAAAJ&hl=en Papers Published in Indexed Journals Himanshu Gupta, Sanyog Jain, Rashi Mathur, A.K. Mishra, Pushpa Mishra, T.Velpandian, Sustained ocular drug delivery from a temperature and pH triggered in-situ gel system, Drug Delivery 14(8) 2007, 507-515. Himanshu Gupta, M. Aqil, R.K. Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mittal, Sanyog Jain. Development…
TALLC Corporation Inc., a pioneering pharmaceutical company using proprietary new molecular entities to treat acute and chronic inflammation, has been granted patent GB2561009 from the United Kingdom
The Report Ocular Drug Delivery Technology Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2017 - 2025 provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - MarketResearchReports.biz. This report on the Global Ocular Drug Delivery Technology market analyzes the current and future scenario of the global market. Rise in private and public funding for R&D of novel drug delivery technologies, increase in prevalence of macular degeneration & diabetic retinopathy, and favorable regulatory scenario for introduction of innovative technologies are boosting the growth of the Global Ocular Drug Delivery Technology market. Rising demand for targeted drug delivery to the affected ocular tissue, and elimination of drug due to nasolacrimal drainage system when administered via topical route are some of the factors expected to drive the growth of Global Ocular Drug Delivery Technology market during the forecast ...
purpose. To assess the impact of an episcleral exoplant on transscleral delivery.. methods. New Zealand White rabbits were given a periocular injection of sodium fluorescein (fluorescein, 376 Da) or an episcleral exoplant loaded with fluorescein. Two types of exoplants were tested: (1) a rigid polyethylene device, impermeable on one side and open to the sclera on the other, that contained compressed pellets of fluorescein and was sutured loosely (apposition group) or tightly to indent the sclera (indentation group) and (2) flexible refillable silicone exoplants also open to the sclera that were secured by suturing, to form a sealed episcleral chamber that was filled with a fluorescein solution. Ocular and plasma fluorophotometry were performed at several time points, and histology was performed to evaluate the effect of exoplants on the periocular tissue.. results. Within 20 minutes of a periocular injection of fluorescein, peak fluorescence was visible in the anterior chamber (AC) and at later ...
BOSTON - For nearly half a century, contact lenses have been proposed as a means of ocular drug delivery that may someday replace eye drops, but achieving controlled drug release has been a significant challenge. Researchers at Massachusetts Eye and Ear/Harvard Medical School Department of Ophthalmology, Boston Childrens Hospital, and the Massachusetts Institute of Technology are one step closer to an eye drop-free reality with the development of a drug-eluting contact lens designed for prolonged delivery of latanoprost, a common drug used for the treatment of glaucoma, the leading cause of irreversible blindness worldwide. In general, eye drops are an inefficient method of drug delivery that has notoriously poor patient adherence. This contact lens design can potentially be used as a treatment for glaucoma and as a platform for other ocular drug delivery applications, said Joseph Ciolino, M.D, Mass. Eye and Ear cornea specialist and lead author of the paper. The contacts were designed with ...
Development of newer drug carrier systems by the researchers has resulted in numerous breakthroughs in the development and manufacturing of ocular products. The ocular bioavailability of drugs at the posterior segment of the eye is a challenging task in the present scenario. Naturally derived macromolecular carriers are widely used to increase the efficacy of ocular drugs. They provide enhanced corneal permeability and retention effect at the surface of cornea for a prolonged period of time. In this regimen the present review focuses towards the major ocular diseases and their prevalence and development of efficient drug carrier systems utilizing various naturally derived macromolecules for improved delivery of drugs to treat ocular diseases ...
The objective of the present study was to prepare controlled release formulation of Moxifloxacin hydrochloride ocular nanoparticles. The nanoparticles were prepared by solvent displacement method using Eudragit RL 100 as a polymer. Different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. The formulations were evaluated in terms of particle size, FTIR, drug entrapment efficiency and in vitro drug release profile was examined. The anti bacterial activity against gram positive and gram negative bacteria were determined. In vivo studies were carried out by Draize test. The mean particle size for drug loaded formulations was found to be below 200 nm. The zeta potential remained in the range of positive values for all batches +10 mV to +40mV. The formulation possesses good antibiotic activity against Escherichia coli, Bacillus subtilus and Staphylococcus aureus microorganism and no eye irritation on in-vivo testing.
Objectives Flavonoids are a common group of plant polyphenols that give colour and flavour to fruits and vegetables. In recent years, flavonoids have gained importance in the pharmaceutical field through their beneficial effects on human health and are widely available as nutritional supplements. Several pharmacological actions of the bioflavonoids may be useful in the prevention or treatment of ocular diseases responsible for vision loss such as diabetic retinopathy, macular degeneration and cataract. This review aims to summarize the potential therapeutic applications of various bioflavonoids in different ocular diseases and also discusses delivery of these agents to the ocular tissues.. Key findings It is apparent that the flavonoids are capable of acting on various mechanisms or aetiological factors responsible for the development of different sight threatening ocular diseases. From a drug delivery perspective, ocular bioavailability depends on the physicochemical and biopharmaceutical ...
A sympathomimetic with alpha-adrenergic activity. It has a vasoconstrictor effect that reduces mucosal swelling and congestion. Topical nasal use (single dose) or ophthalmological (2-4 times a day). Since the last update we have not found published data in relation to breastfeeding. The small dose and the low plasma absorption of most topical nasal or ophthalmological preparations make transfer into breastmilk in significant amounts unlikely. Do not exceed the recommended dose and time periods in order to avoid undesirable side effects and the possible decrease in milk cited by some authors (Nice 2000) for other similar drugs, although not proven in practice. It is a product which has very little literature and almost none related to pharmacokinetics. As a nasal decongestant, it is discouraged by some authors (Nice 2000), with better known drugs from the same group being preferred (Anderson 2000). Ophthalmic administration is fully compatible with breastfeeding. Absorption can be
As a drug-related phenomenon, bronchospasm may present in an isolated fashion or as a component of anaphylaxis. Many drugs are associated with bronchospasm (Figure 2), but the prototypic medications of concern are beta-blockers, aspirin, and NSAIDs. Drug-induced bronchospasm is of particular concern in patients with asthma or pre-existing airways disease.. The use of beta-blockers in patients with asthma or COPD remains controversial. As beta-agonists are used to treat bronchospasm, it logically follows that beta-blockade may cause bronchospasm. When nonselective beta-blockers were introduced, numerous cases were reported of severe or fatal asthma exacerbations after oral, IV, or even ophthalmic administration.. These cases resulted in recommendations to avoid beta-blockade in patients with asthma or COPD. However, there is abundant evidence that beta-blockers have significant clinical benefit in coronary disease, hypertension, and heart failure; a general avoidance of this therapy in those with ...
Protasis Customer Questionnaire US Letter Template is a fully editable template that can be customized to your needs. It is designed in a way that facilitates the user without the need for specialized knowledge of software and processing. Most of its elements are combined in such a way that the drag n drop technique can be applied. It has a minimum storage space as it has been compressed properly. As a result Protasis Customer Questionnaire US Letter Template will help you design your own corporate questionnaire is handy, functional and stylish. Save time and impress with your professional image! Τhe Protasis Customer Questionnaire US Letter Template has been used with free fonts that you can download freely and install them on your system. The photos are indicative and are not included in the product due to copyright.
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The stacking of discotic molecules (hexakis(alkoxy)diquinoxalino[2,3-a:2,3-c]phenazines) in the columnar phase sandwiched between two flat glass substrates has been studied. The surface free energy of the substrates, measured by means of sessile drop technique, is found to have significant influence on the way that the discotic molecules anchor on the surface, and a steady thermal state of the system is crucial for a homogenous orientation of the discotic columns. On a surface of high free energy, the discotic molecules anchor with their disc-face toward the surface. A decrease in the surface free energy of the substrate causes the discotic columns to tilt away from the normal of the substrate.
This is an open-label study in patients who are currently using either a topical prostaglandin as sole ocular hypotensive medical therapy q.d., or a topical prostaglandin plus an adjunctive topical ocular hypotensive marketed product either q.d., or b.i.d. in the same eye(s). Compliance will be measured over the two months of participation ...
Ohr Pharmaceutical, Inc. is a pharmaceutical company focused on the development of therapeutics and delivery technologies for the treatment of ocular disease. The Companys development pipeline consists of several programs and indications at various stages of development. Its product pipeline includes Squalamine Lactate Ophthalmic Solution 0.2% (Squalamine, also known as OHR-102), SKS Sustained Release Ocular Drug Delivery Platform Technology, Animal Model for Dry- Age-Related Macular Degeneration (AMD) and Non-Ophthalmology Assets. OHR-102 is a therapeutic product that provides a non-invasive therapy to improve vision outcomes. The SKS sustained release technology is designed to develop drug formulations for ocular disease. In the Companys animal model for dry-AMD, mice are immunized with a carboxyethylpyrrole, which is bound to mouse serum albumin. It also owns various other compounds in earlier stages of development, including the PTP1b inhibitor Trodusquemine and related analogs.
Find everything you need to know about Simbrinza (Brimonidine And Brinzolamide Ophthalmic), including what it is used for, warnings, reviews, side effects, and interactions. Learn more about Simbrinza (Brimonidine And Brinzolamide Ophthalmic) at EverydayHealth.com.
Pharmacological inhibition of matrix metalloproteinase-2 (MMP-2) is a promising target for acute cardioprotection against ischemia/reperfusion injury. Therefore, here we investigated if the MMP inhibitor ilomastat administered either before ischemia or before reperfusion is able to reduce infarct si …
Semantic Scholar extracted view of Comparison of the Uptake and Retention of Carcinogen by Breast and Fat (after Feeding) and Skin (after Topical Administration). by Fred G. Bock
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Title:Betaxolol Hydrochloride Loaded Chitosan Nanoparticles for Ocular Delivery and their Anti-glaucoma Efficacy. VOLUME: 10 ISSUE: 5. Author(s):Kunal Jain, R. Suresh Kumar, Sumeet Sood and G. Dhyanandhan. Affiliation:Department of Pharmaceutics, J.S.S College of Pharmacy, Udhagamandalam, India.. Keywords:Betaxolol, glaucoma, chitosan, nanoparticles, ocular delivery.. Abstract:Many effective anti-glaucoma drugs available for the treatment of ocular hypertension and open angle glaucoma are associated with rapid and extensive precorneal loss caused by the drainage and high tear fluid turnover. The present study involved design of mucoadhesive nanoparticulate carrier system containing betaxolol hydrochloride for ocular delivery to improve its corneal permeability and precorneal residence time. Nanoparticles were prepared by spontaneous emulsification method and had a particle size of 168-260nm with zeta potential of 25.2-26.4 mV. The in vitro release studies in simulated tear fluid exhibited ...
An ophthalmic drugs are medication used to treat eye infections. Ophthalmic drug forms have been one of the most important and widely developed areas of pharmaceutical technology over the few years.The global ophthalmic drugs market is expected to register significant growth in the forecoming years. Major factors dr...
Some of the key players operating in the global Ophthalmic Drugs Market are ALLERGAN, Aerie Pharmaceuticals, Inc., Pfizer Inc., Valeant Pharmaceuticals International, Inc., Bayer AG, Genentech, Inc., Novartis AG , Regeneron Pharmaceuticals, Inc., Shire, and Santen Pharmaceutical Co., Ltd. Novartis, of them, is a leading player, which held a share of 12% in the market in 2012.. Noticeable trends in the global ophthalmic drugs market are keen players entering into co-development agreements to formulate novel biological agents having lesser treatment durations, emerging market players focusing on unmet medical needs in ophthalmology, and generic manufacturers bolstering their distribution networks of affordable drugs in rural areas of developing regions, having maximum visually challenged people.. As per a report by Transparency Market Research, the global ophthalmic drugs market will likely attain a value of US$34.3 bn by 2025 from US$24.4 bn in 2016 by registering a tepid CAGR of 4.0% from 2017 ...
Non-aqueous oil delivery system for ophthalmic drugs - The present invention relates to a delivery system for ophthalmic drugs, and more particularly, to a non aqueous oil delivery system. Low concentrations of ophthalmic drugs suspended in an oil vehicle delivery system are as therapeutically effective in man and animals as the corresponding higher concentrations of ophthalmic drugs that are commercially used in aqueous solutions. Eye drops that utilize this nonaqueous oil delivery system, when used in man, are comfortable to use and produce little ocular irritation, have a longer shelf-life, low systemic toxic potential, and only short term blurring of vision. Using this nonaqueous oil delivery system, a single drop of ophthalmic drug with a concentration that is 10 times less than the same drug used in commercially available aqueous eye drops is as effective as the commercially available aqueous ophthalmic eye drops that require many applications to be effective. In addition, utilizing the ...
Increased absolute and relative liver and kidney weights and increased severity of spontaneous renal lesions (females), increased prostration (females), and swollen periocular tissue (males and females ...
The global ophthalmic drugs market size was valued at USD 31.0 billion in 2019 and is expected to expand at a CAGR of 5.0% from 2019 to 2027. Rising prevalence of eye diseases and disorders along with presence of robust pipeline of molecules are some of the key factors driving the growth
Research Report on Asia-Pacific Ophthalmic Drugs Market Report 2017. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
Research Report on Global Ophthalmic Drugs Sales Market Report 2017. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
Study Flashcards On Module 5/Pharmacology and Disease/Section 9/Pharmacology/Ophthalmic Drugs at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Ophthalmic Drugs Market will likely attain a value of US$34.3 bn by 2025 from US$24.4 bn in 2016 by registering a tepid CAGR of 4.0% from 2017 to 2025.
This is the business view business. Photokeratitis or ultraviolet keratitis is a painful eye condition, caused by exposure of insufficiently protected eyes to the ultraviolet (UV) rays from either natural or artificial sources. Photokeratitis is akin to a sunburn of the cornea and conjuncti...
Binary methanol/water mixture bubble point tests involving three samples of fine-mesh, stainless steel screens as porous liquid acquisition devices are presented in this article. Contact angles are measured as a function of methanol mass fraction using the Sessile Drop technique. Pretest predictions are based on a Langmuir isotherm fit. Predictions and data match for methanol mole fractions greater than 50% when pore diameters are based on pure liquid tests. For all three screens, bubble point is shown to be a maximum at a methanol mole fraction of 50%. Model and data are in disagreement for mole fractions less than 50%, which is attributed to variations between surface and bulk fluid properties. A critical Zisman surface tension value of 23.2 mN/m is estimated, below which contact angles can be assumed to be zero. Solid/vapor and solid/liquid interfacial tensions are also estimated using the equation of state analysis from Neumann and Good. Published 2013 American Institute of Chemical ...
Brinzolamide reduces the amount of fluid in the eye, which decreases pressure inside the eye. Brinzolamide ophthalmic (for the eyes) is used to treat certain types of glaucoma and other causes of high pressure inside the eye. Brinzolamide ophthalmic may also be used for other purposes not listed in this medication guide.
This is especially important for a chronic condition such as glaucoma, for example. When it comes to treating glaucoma, healthcare providers have a broad array of increasingly invasive treatments for managing intraocular pressure (IOP), starting with simple topical drug formulations before moving up to stents and possibly even surgery. Therefore, if a patient has compliance and adherence issues with their initial topical treatments, it increases the probability that IOP will not be well-managed and that more drops would have to be prescribed to try to manage IOP before moving on to increasingly invasive, surgical treatments.. AcuStreams clear benefits position it for success in the topical ophthalmic market, in the treatment of conditions such as glaucoma, dry eye, uveitis, allergic disease and infections. Additionally, the regulatory pathway to approval for AcuStream combined with approved drugs can follow streamlined processes such as the US FDAs 505(b)(2) approval pathway. Because of its ...
In a growing trend towards streamlining and standardization of quality control and compliance methodologies, HUD has introduced a Defect Taxonomy in its FHAs Single Family Housing Loan Quality Assessment Methodology. This document lays out the methodology that the FHA plans to adopt to improve its own QA efforts.. Knowing how FHA will be evaluating loans is helpful in designing your own QA program. Particularly useful is the definition of nine defect categories, numerous sources/causes for the defects, and four levels of defect severity. These can be roughly translated in Cogentspeak to audit question categories, preset comments, and findings levels respectively.. For those configuring their Cogent FHA audit shells: your work has just become easier and more complex at the same time.. ...
Meet top and best Ophthalmologist, Optometrists, Eye surgeons and Medical professionals from Europe, USA, middle-east, Asia pacific, at Ophthalmology conferences, Eye care Conferences scheduled during October 28-29, 2020 in Amsterdam, Netherlands
View drug interactions with ophthalmic irrigation, extraocular ophthalmic. This medication may also interact with certain foods or diseases.
OConnor Daviess ophthalmic drugs : diagnostic and therapeutic uses. by Davies, P. H. OConnor (Patrick Henry OConnor), 1922 , Hopkins, G. A , Pearson, R. M. (Richard M.) , Davies, P. H. OConnor (Patrick Henry OConnor), 1922-. Actions and uses of ophthalmic drugs.. Edition: 4th ed. / revised by Graham Hopkins, Richard Pearson.Material type: ...
I want to credit the insight given to me from Dr. Doug Rett, OD, FAAO:. In 1958 Muro Pharmacal Labs was founded and it manufactured ophthalmic drugs. It was named Muro for the Italian word for wall, which I think is fitting given the barrier that the cornea plays in penetration of ocular drugs. With tight junctions, pH sensitivity and the hydrophobic nature of the epithelium and hydrophilic nature of the stroma, its difficult for modern-day drug companies to pass medication through the cornea, let alone in the 1950s. In 1968 Muro was sold to George Behrakis, a pharmacist from Lowell, […]. ...
By Abhirup Mandal and Ashim K. Mitra Ocular delivery of biologics has been challenging. It has been a constant source of exasperation for ophthalmologists and formulation experts over the last few decades. High-molecular weight, short half-lives, structural complexity, and poor permeability render biologics as the most challenging molecules to formulate and deliver across ocular barriers. Since…
The EpiCorneal 3D human tissue model provides a highly predictive non-animal alternative to assess ophthalmic drug delivery, wound healing and tissue regeneration, disease modeling (e.g. dry eye) and corneal infection.. Details ...
AIMS: Corneal perfusion chambers are important tools in the development and assessment of ophthalmic drugs. The aim of this study was to design and test a modified perfusion chamber suitable for topical application of drugs ...
Free flashcards to help memorize facts about Ophthalmic Drugs Chapter 18. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests.
D (Injection, Inhalation); B (Ophthalmic) (US). Routes of. administration. IV, IM, inhalation, ophthalmic. ... Ophthalmic (tobramycin only, Tobrex, or combined with dexamethasone, sold as TobraDex) and nebulised formulations both have low ... tobramycin sterile ophthalmic solution is produced by Bausch & Lomb Pharmaceuticals. Benzalkonium chloride 0.01% is added as a ...
U.S. Food and Drug Administration. Archived from the original on 1 January 2009. "Suprofen ophthalmic". Drugs.com. v t e. ... It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic ...
"Drug Approval Package: Nepafenac Ophthalmic Suspension, 0.3% NDA #203491". U.S. Food and Drug Administration (FDA). April 8, ... "Drug Approval Package: Nevanac (Nepafenac) Ophthalmic Suspension NDA #021862". U.S. Food and Drug Administration (FDA). January ... Gaynes BI, Onyekwuluje A (June 2008). "Topical ophthalmic NSAIDs: a discussion with focus on nepafenac ophthalmic suspension". ... On February 25, 2005, Alcon filed a New Drug Application (NDA) with the U.S. Food and Drug Administration (FDA) for Nevanac 0.1 ...
Ophthalmic drug administration‎ (10 P). *. Ophthalmic equipment‎ (1 C, 32 P). *. Ophthalmologists‎ (7 C, 3 P) ...
"Rhopressa (netarsudil) Ophthalmic Solution". U.S. Food and Drug Administration (FDA). 29 January 2018. Retrieved 3 June 2020. " ... In the United States in December 2017, the Food and Drug Administration (FDA) approved a 0.02% ophthalmic solution for the ... New Drug Therapy Approvals 2017 (PDF). U.S. Food and Drug Administration (FDA) (Report). January 2018. Retrieved 16 September ...
The concomitant administration of a non-steroidal anti-inflammatory drug (NSAID) with a quinolone, including norfloxacin, may ... Merck Sharp & Dohme (September 2000). "Chibroxin (Norfloxacin) Ophthalmic solution" (PDF). USA: FDA. Arabyat RM, Raisch DW, ... Administration of magnesium, aluminum, or calcium containing antacids can reduce the absorption of norfloxacin. Norfloxacin is ... The concomitant administration of quinolones including norfloxacin with glyburide (a sulfonylurea agent) has, on rare occasions ...
"Lastacaft (alcaftadine ophthalmic solution 0.25%)" (PDF). Drug Use Review. U.S. Food and Drug Administration. 21 June 2012. ... "Drug Approval Package: Lastacaft (alcaftadine) Ophthalmic Solution NDA #022134". U.S. Food and Drug Administration (FDA). 24 ... The most common seen side effect of alcaftadine administration was irritation or a stinging sensation at the administration ... It was approved by the U.S. Food and Drug Administration (FDA) in July 2010, under the trade name Lastacaft. Alcaftadine is an ...
Food and Drug Administration (Press release). 10 July 2018. Retrieved 15 April 2019. "Levofloxacin ophthalmic medical facts ... Following oral administration, 87% of an administered dose was recovered in the urine as unchanged drug within 2 days. Less ... Peak levels in skin are achieved 3 hours after administration and exceed those in plasma by a factor of 2. Similarly, lung ... It was first approved for marketing in Japan in 1993, for oral administration, and Daiichi marketed it there under the brand ...
United States Food and Drug Administration (Nov. 2006). Xalatan (latanoprost ophthalmic solution) 0.005% (50 μg/mL). Accessed 5 ... In animal studies using four times the therapeutic concentration of the ophthalmic solution latanoprost, the size of the ...
Ophthalmic Practice 1995; 13:126-133. Burnstein Y, Hersh PS. Photorefractive keratectomy following radial keratotomy. J Refract ... CS1 maint: discouraged parameter (link) "ViewPoint™ CK System - P010018". Food and Drug Administration. Hersh, Peter (2005). " ... "Summary minutes of the ophthalmic devices panel meeting" (PDF). www.fda.gov. Retrieved November 30, 2001. ... Food and Drug Administration (FDA) of the excimer laser for the correction of nearsightedness in the United States. Hersh was ...
John Ophthalmic Hospital, Jerusalem. Joan Honor, Assistant Administrator, War on Want. William John Hood, District Inspector, ... Fred Horton, JP, Personnel and Administration Officer, Prestwick Airport, British Airports Authority. Joseph Arthur Horton, ... Ernest Michael Miller, Chief Administration Officer, The Football Association. Mary Edwina Millican, Honorary Secretary, ... Barbara Eileen Sanders, Senior Personal Secretary, Office of the Parliamentary Commissioner for Administration. Gwendolen ...
The Food and Drug Administration (FDA) has no "tanning pills" approved for sale in the United States. In spite of this, there ... Ophthalmic Research. 46 (2): 103-106. doi:10.1159/000323813. PMID 21346389. S2CID 7495247. "Warning Letters Cite Cosmetics as ... "Sun Safety: Protect the Skin You're In!". FDA & You, Issue #3. Food and Drug Administration. Spring-Summer 2003. Archived from ... "Code of Federal Regulations Title 21, 1 April 2012". Food and Drug Administration. Retrieved 2013-06-21. "Feeds Regulations, ...
First Secretary (Administration), H M. Embassy, Berlin. Robert Alan Minchell, Director of Surveys, Government of Malawi. James ... Alison Gordon Kiddie, Ward Sister, Ophthalmic Ward, Dundee Royal Infirmary. Freeman Atkinson Kiddle, Central Planning Engineer ... For services to the administration of justice in Belize. Arthur Thomas Draper, Managing Director, Produce Marketing Board, The ... George Bernard Doggett, lately Administration Officer, British Trade Commission, Hong Kong. Major Gerald Foster Doggett, MC, ...
Richard Leslie Bellis, Ophthalmic Optician, Department of Health and Social Security. Thomas Benson, Chief Engineer, Menswear ... John Granville Galilee, Honorary Secretary, Institute of Shops Acts Administration. Edith Eileen Gallagher. For services to the ... Harold Sydney Peters, MBE, lately Permanent Secretary (Administration), Office of the President and Cabinet, Malawi. Edgar ... Dennis George Plaister, MBE, Senior Principal, Office of the Parliamentary Commissioner for Administration. Samuel Walter Potts ...
U.S. Food and Drug Administration. 39 (3): 8-9. PMID 16127813. Archived from the original on January 20, 2009. Retrieved 14 May ... Soparkar, Charles N. S. (1997-01-01). "Acute and Chronic Conjunctivitis Due to Over-the-counter Ophthalmic Decongestants". ... Hessen, Michelle; Akpek, Esen Karamursel (April 2014). "Dry Eye: an Inflammatory Ocular Disease". Journal of Ophthalmic & ...
Administration[edit]. Oral or intravenous; dosing varies by purpose and route of administration as well as patient weight. ... This is accomplished via transarterial catheter based slow pulsed infusion into the ophthalmic artery.[4] ...
Duvall, Brian; Kershner, Robert M. (2006). Ophthalmic Medications and Pharmacology. Journal of Ophthalmic Nursing & Technology ... Food and Drug Administration (FDA). 9 April 2018. Retrieved 11 March 2020. "Altafluor- fluorescein sodium and benoxinate ... "Drug Approval Package: Altafluor Benox (fluorescein sodium and benoxinate hydrochloride ophthalmic solution)". U.S. ...
Director of Academic Administration, University of Kent and of UK Socrates-Erasmus Office. For services to Higher Education and ... Formerly consultant Ophthalmic Surgeon, Princess Alexandra Eye Pavilion, Royal Infirmary of Edinburgh. For services to Medicine ... Head of Policy, Administration and Finance Section, Invest UK, Department of Trade and Industry. (London, W6) Douglas Alexander ... For services to the Administration of Justice and to the community in Hampshire. (Alton, Hampshire) John Vincent Palmer. ...
... due to variable absorption from the stomach mucosa and an increased side-effect profile versus ophthalmic administration. The ... "Brinzolamide ophthalmic (Azopt) Use During Pregnancy". Drugs.com. 16 May 2019. Retrieved 17 August 2020. "Archived copy". ... Sall KN, Greff LJ, Johnson-Pratt LR, et al.: Dorzolamide/timolol combination versus concomitant administration of brimonidine ... Food and Drug Administration (FDA). Retrieved 13 February 2021. Croxtall JD, Scott, LJ.[1] Archived 2011-10-08 at the Wayback ...
An editorial by Jerry Gurwitz in the same issue called for the Food and Drug Administration (FDA) to consider giving Tequin a ... By contrast, ophthalmic gatifloxacin is generally well tolerated. The observed systemic concentration of the drug following ... Therefore, the systemic exposures resulting from the gatifloxacin ophthalmic solution are not likely to pose any risk for ... Gatifloxacin is currently available in the US and Canada only as an ophthalmic solution. In 2011, the Union Health and Family ...
Ophthalmology: VisionCare Ophthalmic Technologies Inc., a miniature telescope for age-related macular degeneration (AMD). In ... This vote overturned the "not approvable" recommendation from a Food & Drug Administration advisory panel in 2006. The ... March 2009, the FDA Ophthalmic Devices Advisory Panel voted 8-0 to approve, with conditions including post-approval studies, ...
"Food and Drug Administration. Retrieved 2011-10-27.. *^ "Current EU approved additives and their E Numbers". Food Standards ... Hueber, A.; Rosentreter, A.; Severin, M. (2011). "Canthaxanthin Retinopathy: Long-Term Observations". Ophthalmic Research. 46 ( ... "Food and Drug Administration. Retrieved 2013-06-21.. *^ "Feeds Regulations, 1983 (SOR/83-593)". Justice Laws, Canada. Archived ... The Food and Drug Administration (FDA) has no "tanning pills" approved for sale in the United States. In spite of this, there ...
administration. By mouth (tablets). Solution for injection. Topical (ophthalmic solution). ATC code. *N07AB01 (WHO) S01EB02 ( ... It is primarily used for various ophthalmic purposes, such as for treating glaucoma, or for use during ophthalmic surgery. It ... Carbachol is primarily used in the treatment of glaucoma, but it is also used during ophthalmic surgery.[2] Carbachol eyedrops ... Topical ocular administration is used to decrease intraocular pressure in people with primary open-angle glaucoma. Intraocular ...
... ophthalmic, otologic, and urogenital). Oral administration, the most common form of enteral administration, can be performed in ... Administration is the process by which a patient takes a medicine. There are three major categories of drug administration; ... require special handling during administration, require patient monitoring during and immediately after administration, have ... In the U.S., the Elixir Sulfanilamide disaster led to the establishment of the Food and Drug Administration, and the 1938 ...
The U.S. Food and Drug Administration in 2007 cleared an endotracheal tube with a fine coat of silver to reduce the risk of ... In the early 20th century, physicians used silver-containing eyedrops to treat ophthalmic problems, for various infections, and ... A number of wound dressings containing silver as an anti-bacterial have been cleared by the U.S. Food and Drug Administration ( ... "[email protected]". U.S. Food and Drug Administration (FDA). Archived from the original on 2014-09-05. Retrieved 2010-07-10. Norman G, ...
administration. Oral, Ophthalmic. Legal status. Legal status. *Prescription only. Pharmacokinetic data. Biological half-life. 6 ...
Most ADRs relate to administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia, however ... Levobupivacaine is indicated for local anaesthesia including infiltration, nerve block, ophthalmic, epidural and intrathecal ...
Ophthalmic Devices Panel" (PDF). www.fda.gov. FDA Division of Ophthalmic and Ear, Nose and Throat Devices. p. 97. Archived from ... Soft contact lenses are one of several types on the U.S. Market approved by the U.S. Food and Drug Administration for ... The U.S. Food and Drug Administration (FDA) classifies soft contact lenses into four groups for the U.S. Market. They are also ... U.S. Food and Drug Administration. n.d. p. 25. Archived from the original (PDF) on 1 May 2015. Retrieved 18 June 2016. CS1 ...
He became the University's first Professor of Social Administration. and authored many papers for British and overseas journals ... Kaim-Caudle, Peter (1970). Ophthalmic Services in Ireland. The Economic and Social Research Institute. Kaim-Caudle, Peter (1973 ...
... begins with the contraction of the muscles attached to the rib cage; this causes an expansion in the chest cavity. Then takes place the onset of contraction of the diaphragm, which results in expansion of the intrapleural space and an increase in negative pressure according to Boyle's law. This negative pressure generates airflow because of the pressure difference between the atmosphere and alveolus. Air enters, inflating the lung through either the nose or the mouth into the pharynx (throat) and trachea before entering the alveoli.[citation needed] Other muscles that can be involved in inhalation include:[2] ...
Some feel that the term tisane is more correct than herbal tea or that the latter is even misleading, but most dictionaries record that the word tea is also used to refer to other plants beside the tea plant and to beverages made from these other plants.[4][5] In any case, the term herbal tea is very well established and much more common than tisane.[1] The word tisane was rare in its modern sense before the 20th century, when it was borrowed in the modern sense from French. (This is why some people feel it should be pronounced /tɪˈzɑːn/ as in French, but the original English pronunciation /tɪˈzæn/ continues to be more common in US English and especially in UK English).[2] The word had already existed in late Middle English in the sense of "medicinal drink" and had already been borrowed from French (Old French). The Old French word came from the Latin word ptisana, which came from the Ancient Greek word πτισάνη (ptisánē), which meant "peeled" barley, in other words pearl barley, ...
"U.S. Food and Drug Administration (FDA). 2018-11-03.. *^ a b c "Isotretinoin 20mg capsules - - (eMC)". www.medicines.org.uk. ... Kremer I, Gaton DD, David M, Gaton E, Shapiro A (1994). "Toxic effects of systemic retinoids on meibomian glands". Ophthalmic ... "U. S. Food and Drug Administration (FDA). Retrieved 20 January 2014.. *^ Gina Kolata for the New York Times. April 22, 1988 ... "U. S. Food and Drug Administration (FDA). Retrieved 20 January 2014.. *^ "FDA information, side effects, and uses / Accutane ( ...
Common applications are ophthalmic surgery, in combination with local anesthetics. It also increases the absorption rate of ...
Many systems of administration employ a drip chamber, which prevents air from entering the blood stream (air embolism), and ... Compared with other routes of administration, such as oral medications, the intravenous route is the fastest way to deliver ... One reason veins are preferred over arteries for intravascular administration is because the flow will pass through the lungs ... The intravenous route of administration can be used for injections (with a syringe at higher pressures) or infusions (typically ...
Oxygen helmets are used in hyperbaric oxygen chambers for oxygen administration.[1] They are transparent, lightweight plastic ... Oxygen helmets are often preferred for oxygen administration in hyperbaric oxygen chambers for children and patients that are ... and hyperbaric chamber and other patients who require administration of pure oxygen, such as carbon monoxide poisoning and ...
"Ketorolac ophthalmic medical facts from". Drugs.com. Retrieved 2013-10-06.. *^ "Sprix Information from". Drugs.com. Retrieved ... "U.S. Food and Drug Administration. 21 July 2017. Retrieved 15 October 2020.. This article incorporates text from this source, ... "U.S. Food and Drug Administration (FDA) (Press release). 15 October 2020. Retrieved 15 October 2020.. This article incorporates ... In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti- ...
Routes of administration. [40][41][42] Pharmacokinetics[39] Indications. [40][41][42] Major safety concerns. [40][41][42] ... McCormack PL (July 2011). "Ketorolac 0.45% ophthalmic solution". Drugs & Aging. 28 (7): 583-9. doi:10.2165/11207450-000000000- ... Protein binding = 35%; extensive hepatic metabolism, with some metabolism occur in the gut after oral administration; half-life ...
European Ophthalmic Review. 11 (1): 59. doi:10.17925/eor.2017.11.01.59.. ... "Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration". Molecular ... the ophthalmic artery bifurcates and supplies the retina via two distinct vascular networks: the choroidal network, which ...
administration. Oral (capsule, tablet or suspension), intravenous, ophthalmic. ATC code. *J01FA10 (WHO) S01AA26 ...
U.S. Food and Drug Administration. *↑ Charters, Linda Anticipation is key to managing intra-operative floppy iris syndrome ആർ ... Deshpande, Vijaya (2000). "Ophthalmic surgery: a chapter in the history of Sino-Indian medical contacts". Bulletin of the ...
A new method of drug administration". Current Researches in Anesthesia and Analgesia. 26 (6): 221-230. PMID 18917536.. ... August 14, 2014: The U.S. Food and Drug Administration (FDA) approved the use of the PharmaJet Stratis 0.5ml Needle-free Jet ... Warren, J; Ziherl, FA; Kish, AW; Ziherl, LA (1955). "Large-scale administration of vaccines by means of an automatic jet ... Needle-free Injector Receives WHO PQS Certification as a Pre-qualified Delivery Device for Vaccine Administration". ...
... after either ophthalmic or intravenous administration.[20] However, ophthalmic use is done with sterile filtered drugs that is ... it does not correct hyponatremia as rapidly as administration of hypertonic saline does. Due to hypertonicity, administration ... Water privation combined with diuretic block does not produce as much risk of CPM as saline administration does; however, ... or ophthalmic, which is compared to intravenous use; By demonstration, the elimination of latanoprost acid from plasma is rapid ...
In July 2018, the Food and Drug Administration approved tecovirimat, the first drug approved for treatment of smallpox.[60] ... Ophthalmic zoster. *Disseminated herpes zoster. *Zoster-associated pain. *Modified varicella-like syndrome ...
In the US, due to its potential to irritate the skin, the U.S. Food and Drug Administration (FDA) did not approve its use as a ... "Similarities in the packaging of cyanoacrylate nail glue and ophthalmic preparations: an ongoing problem". British Journal of ...
If defined strictly as having local effect, the topical route of administration can also include enteral administration of ... "Ophthalmic drug dosage forms: characterisation and research methods". TheScientificWorldJournal. 2014: 1-14. doi:10.1155/2014/ ... Most often topical administration means application to body surfaces such as the skin or mucous membranes to treat ailments via ... The definition of the topical route of administration sometimes states that both the application location and the ...
Food and Drug Administration under the Best Pharmaceuticals for Children Act both demonstrated that imiquimod cream applied ... Ophthalmic zoster. *Disseminated herpes zoster. *Zoster-associated pain. *Modified varicella-like syndrome ...
In the United States, the Federal Aviation Administration requires that pilots be tested for normal color vision as part of ... Algis, J.; Vingrys, J.; Cole, Barry L. (1986). "Origins of colour vision standards within the transport industry". Ophthalmic ... Federal Aviation Administration, has established a more accurate assessment of color deficiencies in pilot applicants' red/ ...
United States Food and Drug Administration.. *^ "Adamis Pharmaceuticals Provides Update on U.S. Retail Launch of SYMJEPI". ... Autoinjectors were originally developed for the rapid administration of nerve gas antidotes in kits like the Mark I NAAK. The ... Annex I: List of the names, pharmaceutical form(s), strength(s) of the medicinal product(s), route(s) of administration, ... The intramuscular route is preferred over subcutaneous administration because the latter may have delayed absorption.[4][5] ...
7. Miller D, Stegmann R: Healon: A Comprehensive Guide to its Use in Ophthalmic Surgery. J Wiley, NY, 1983 ... "U S Food and Drug Administration. 26 November 2018. Retrieved 11 March 2019.. ... Other biomedical companies also produce brands of hyaluronan for ophthalmic surgery.[citation needed] ... a clinical treatment with regulatory approval by the US Food and Drug Administration.[25] ...
Interdisciplinary Center for ophthalmic Preventive Medicine and Imaging. *Interdisciplinary Center Erlangen Catalysis Resource ... 1920: The WiSo Faculty (Business Administration, Economics & Social Sciences) is established.. *1927: Science is taken out of ... 2004: Inauguration of the new building at the WiSo Faculty of Business Administration, Economics & Social Sciences in Nuremberg ... is home to a large part of the university's administration ...
... , literally "under the lip", from Latin, refers to the pharmacological route of administration by which ... Upper lip administration[edit]. Some drugs are inactive in the digestive tract, but this can be avoided if held between the ... Sublabial administration should not be confused with sublingual administration, which is under the tongue. The frenulum of the ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Sublabial_administration&oldid=735203906" ...
A softgel is an oral dosage form for medicine similar to capsules. They consist of a gelatin based shell surrounding a liquid fill. Softgel shells are a combination of gelatin, water, opacifier and a plasticiser such as glycerin or sorbitol. Softgels are produced in a process known as encapsulation using the Rotary Die Encapsulation process invented by Robert Pauli Scherer. The encapsulation process has been described as a form/fill/seal process. Two flat ribbons of shell material are manufactured on the machine and brought together on a twin set of rotating dies. The dies contain recesses in the desired size and shape, which cut out the ribbons into a two-dimensional shape, and form a seal around the outside. At the same time a pump delivers a precise dose of fill material through a nozzle incorporated into a filling wedge whose tip sits between the two ribbons in between two die pockets at the point of cut out. The wedge is heated to facilitate the sealing process. The wedge injection causes ...
Ophthalmic drug administration. *Eye drops. *Macular telangiectasia. References[edit]. *^ Gamble, Donny. "Drugs of Abuse". ... Intravitreal is a route of administration of a drug or other substance, in which the substance[1] is delivered into the eye. ... Intravitreal administration of drugs is used to treat various conditions of the eye. ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Intravitreal_administration&oldid=836379009" ...
... s are commonly used on horses following exercise, applied either by rubbing on full-strength, especially on the legs; or applied in a diluted form, usually added to a bucket of water and sponged on the body. They are used in hot weather to help cool down a horse after working, the alcohol cooling through rapid evaporation, and counterirritant oils dilating capillaries in the skin, increasing the amount of blood releasing heat from the body.[17] Many horse liniment formulas in diluted form have been used on humans, though products for horses which contain DMSO are not suitable for human use, as DMSO carries the topical product into the bloodstream.[18] Horse liniment ingredients such as menthol, chloroxylenol, or iodine are also used in different formulas in products used by humans.[19] Absorbine, a horse liniment product manufactured by W.F. Young, Inc., was reformulated for humans and marketed as Absorbine Jr.[20] The company also acquired other liniment brands including Bigeloil and ...
for buccal administration when solution for oromucosal administration is not available *^ The presence of both 25 mg/5 mL and ... 14.1 Ophthalmic medicines. *14.2 Radiocontrast media. *15 Disinfectants and antiseptics *15.1 Antiseptics ... cloxacillin, dicloxacillin and flucloxacillin are preferred for oral administration due to better bioavailability. ...
"U.S. Food and Drug Administration. 2011. Retrieved 2013-04-11.. *^ Gaslin MT, Rubin C, Pribitkin EA (2008). "Silver nasal ... physicians used silver-containing eyedrops to treat ophthalmic problems,[74] for various infections,[75][76] and sometimes ... "Australian Therapeutic Goods Administration. 2005-11-09. Retrieved 2008-09-22.. *^ FDA Consumer Advisory (October 6, 2009). ... The U.S. Food and Drug Administration in 2007 cleared an endotracheal tube with a fine coat of silver to reduce the risk of ...
催乳素(英语:Template:Prolactin inhibitors and anti-inflammatory products for vaginal administration) ... Ophthalmic zoster(英语:Ophthalmic zoster). *带状疱疹. *Zoster-associated pain(英语:Postherpetic neuralgia) ...
Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical ... This drainage is thought to be the reason that systemic side effects exist from such administration. The U.S. Centers for ... ISBN 978-81-8061-099-8. Li CC, Chauhan A (May 2006). "Modeling Ophthalmic Drug Delivery by Soaked Contact Lenses". Industrial ... Center for Devices and Radiological Health (28 October 2019). "Contact Lenses". U.S. Food and Drug Administration (FDA). ...
By requiring systemic administration in cyclosporin treatment of opthalmic diseases not limited to the eye surface, a patient ... The cyclosporin may be topically administered as an ophthalmic drop or ophthalmic ointment containing an effective amount of ... Ophthalmic compositionn and method of using same. US4937078 *. Aug 26, 1988. Jun 26, 1990. Mezei Associates Limited. Liposomal ... Veterinary treatment of ophthalmic disease in animals using toptical tacrolimus. US20040121944 *. Dec 20, 2002. Jun 24, 2004. ...
Long Term Administration Study of OPC-12759 Ophthalmic Suspension. The safety and scientific validity of this study is the ... Long Term Administration Study of OPC-12759 Ophthalmic Suspension in Dry Eye Patients. ... Experimental: OPC-12759 Ophthalmic suspension Instillation, 4times/day. Drug: OPC-12759 Ophthalmic suspension Instillation, ... The purpose of this study is to evaluate safety and efficacy of OPC-12759 ophthalmic suspension during 52 weeks in dry eye ...
... dextran ophthalmic kit) comes in different strengths and amounts. The appearance of Photrexa Viscous can differ based on the ...
Pharmacokinetics and Safety of Topical Administration of Brimonidine Tartrate Ophthalmic Solution 0.025%.. The safety and ... Pharmacokinetics and Safety of Topical Administration of Brimonidine Tartrate Ophthalmic Solution 0.025%. ... Study of the Plasma Pharmacokinetics and Safety Following Topical Administration of Brimonidine Tartrate Ophthalmic Solution ... One drop of brimonidine tartrate ophthalmic solution 0.025% in each eye once at Visit 2 (Day 1) then four times daily (QID) ...
Safety of Polyhexanide (PHMB) 0.08% ophthalmic solution after 26-week repeated-dose ocular administration in rabbits. ... Safety of Polyhexanide (PHMB) 0.08% ophthalmic solution after 26-week repeated-dose ocular administration in rabbits. ... ophthalmic solution after 26-week repeated-dose ocular administration in rabbits.. Invest. Ophthalmol. Vis. Sci. 2017;58(8): ... These favourable results strengthen our plan to develop PHMB 0.08% ophthalmic solution as a novel orphan drug for the treatment ...
Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% ... Purpose: To investigate the penetration of 0.3% gatifloxacin ophthalmic gel, 0.3% gatifloxacin ophthalmic solution and 0.5% ... Keywords: aqueous humor, levofloxacin, gatifloxacin, ophthalmic gel, ophthalmic solution This is an open access article ... Gatifloxacin Ophthalmic Gel, 0.3% Gatifloxacin and 0.5% Levofloxacin Ophthalmic Solutions. Int J Med Sci 2015; 12(6):517-523. ...
Single Administration Sustained Release Formats for Administration of Ophthalmic Medications to the Ocular Surface, Cornea and ... Single Administration Sustained Release Formats for Administration of Ophthalmic Medications to the Ocular Surface, Cornea and ... Shikha P Barman, Koushik Barman, Kevin Ward; Single Administration Sustained Release Formats for Administration of Ophthalmic ...
Ophthalmic). Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more. ... Separate administration of other ophthalmic agents by at least 5 minutes. Do not touch the tip of the dropper to the eye, ... ophthalmic glaucoma agents latanoprost ophthalmic, timolol ophthalmic, epinephrine ophthalmic, Lumigan, Travatan, Xalatan ... Glaucoma, Open Angle latanoprost ophthalmic, timolol ophthalmic, epinephrine ophthalmic, Lumigan, Travatan, Xalatan, More... ...
Ophthalmic). Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more. ... Administration. For topical ophthalmic use only; not for injection into the eye. Avoid contaminating tip of the solution ... ophthalmic anti-infectives azithromycin ophthalmic, ciprofloxacin ophthalmic, levofloxacin ophthalmic, erythromycin ophthalmic ... erythromycin ophthalmic, gentamicin ophthalmic, bacitracin ophthalmic, moxifloxacin ophthalmic, tobramycin ophthalmic, TobraDex ...
Latanoprost Ophthalmic) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related ... Lenses may be reinserted 15 minutes following administration of XALATAN.. Use With Other Ophthalmic Drugs. If more than one ... XALATAN may be used concomitantly with other topical ophthalmic drug products to lower IOP. If more than one topical ophthalmic ... Contact lenses should be removed prior to the administration of XALATAN, and may be reinserted 15 minutes after administration. ...
Isopto Atropine Sterile Topical Ophthalmic Solution (Atropine Sulfate) may treat, side effects, dosage, drug interactions, ... In a study of healthy subjects, after topical ocular administration of 30 μL of atropine sulfate ophthalmic solution, 1%, the ... atropine sulfate) Sterile Topical Ophthalmic Solution 1%. DESCRIPTION. ISOPTO® Atropine 1% is a sterile topical ophthalmic ... after topical ocular administration of 40 μL of atropine sulfate ophthalmic solution, 1%, the mean (± SD) plasma Cmax of l- ...
DOSAGE AND ADMINISTRATION. Desonide lotion should be applied to the affected areas as a thin film two or three times daily ... Not for Ophthalmic Use. DESCRIPTION. Desonide Lotion 0.05% contains desonide, USP (Pregna-1,4-diene-3,20-dione,11,21- dihydroxy ... It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce ...
It is not known whether topical ophthalmic administration of corticosteroids could result in sufficient systemic absorption to ... ophthalmic suspension, USP 1% sterile DESCRIPTION Prednisolone acetate ophthalmic suspension, USP 1% is a sterile, topical anti ... DOSAGE AND ADMINISTRATION Shake well before using. Instill one to two drops into the conjunctival sac two to four times daily. ... Prednisolone acetate ophthalmic suspension, USP 1% is supplied sterile in opaque white LDPE plastic bottles with droppers with ...
Consumer information about the drug atropine ophthalmic used to treat inflammatory conditions of the eye, and is used prior to ... In clinical studies, use of a single topical administration of atropine 1% ophthalmic solution (eye drops) resulted in maximal ... Ophthalmic solution: 1%. How should I keep atropine sulfate ointment-ophthalmic stored?. Atropine ophthalmic solution can be ... atropine ophthalmic. *What is atropine sulfate ointment-ophthalmic, and how does it work (mechanism of action)? ...
Read more about the prescription drug ECHOTHIOPHATE SOLUTION - OPHTHALMIC. ... OPHTHALMIC (Phospholine Iodide), includes side effects, drug interactions, recommended dosages, and storage information. ... Report Problems to the Food and Drug Administration. You are encouraged to report negative side effects of prescription drugs ... GENERIC NAME: ECHOTHIOPHATE SOLUTION - OPHTHALMIC (eck-oh-THIGH-oh-fate). BRAND NAME(S): Phospholine Iodide. Medication Uses , ...
Search for Administration Assistant job opportunities in Montana and apply for the job thats right for you. ... Administration Assistant Jobs in Montana 91 Montana Administration Assistant jobs found on Monster. 91 jobs ... Ophthalmic Assistant. * Show More *Assistant Store Manager. *Chief Administrative Officer *Human Resources Assistant ... Find Montana Administration Assistant jobs on Monster. ... Get Administration Assistant jobs in Montana as soon as theyre ...
Dosage and administration. For external use only. Evert the lower eyelid and instil the ointment liberally into the lower ... Orbenin Ophthalmic Eye Ointment is for the treatment of a range of bacterial infections in the eyes of cattle, sheep, horses, ... Orbenin Ophthalmic Eye Ointment 16.67% w/w is a sterile off-white, viscous stable suspension of Cloxacillin Benzathine in a non ... Orbenin Ophthalmic Eye Ointment is effective against a range of bacteria (including Moraxella spp.) commonly isolated from the ...
... phosphate ophthalmic), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation ... Administration. Topical Ophthalmic Administration. For topical ophthalmic use only; do not inject ... encoded search term (riboflavin 5-phosphate ophthalmic (Photrexa%2C Photrexa Viscous)) and riboflavin 5-phosphate ophthalmic ... topical ophthalmic solution in 3mL glass syringe *0.146% (ie, 1.46mg/mL) in 20% dextran (Photrexa Viscous) ...
... by Joseph ONeill - March 7, 2017. ... Home / Expert Case Studies / Negligent Administration of Ophthalmic Anesthesia Causes Permanent Loss of Vision ... Administration Anesthesiology Blindness Cataract Surgery CRNA Medical Medical Malpractice Optometrist Optometry Retina Vision ... 1. Do you routinely administer ophthalmic anesthesia to patients like the one described above? ...
DOSAGE AND ADMINISTRATION. id: 590a35fc-69b6-4ee2-9c7d-8252b0d1a6ea. displayName: DOSAGE & ADMINISTRATION SECTION. FDA Article ... Mometasone Furoate Ointment 0.1%, For dermatologic use only- not for ophthalmic useDmitri Soroka2018-09-06T09:12:40+00:00 ... Mometasone Furoate Ointment 0.1%, For dermatologic use only- not for ophthalmic use. Home/Mometasone Furoate Ointment 0.1%, For ... Mometasone Furoate Ointment 0.1%, For dermatologic use only- not for ophthalmic use ...
The global ophthalmic drugs market size was valued at USD 31.0 billion in 2019 and is expected to expand at a CAGR of 5.0% from ... Route of Administration Insights. Based on route of administration, the market is segmented into topical, local ocular and ... Ophthalmic Drugs Market Size, Share, Industry Growth Report, 2027 Ophthalmic Drugs Market Size, Share & Trends Analysis Report ... The global ophthalmic drugs market size was valued at USD 31.0 billion in 2019 and is expected to expand at a CAGR of 5.0% from ...
PRNewswire/ -- http://www.visiongain.com/Report/784/Ophthalmic-Drugs-World-Market-Prospects-2012-2022 A new report by ... Food and Drug Administration (FDA) [US]. Fovea Pharmaceuticals. Galderma International SA (Nestlé and LOréal). Genentech. ... Ophthalmic Drugs: World Market Prospects 2012-2022 adds to visiongains range of analytical reports on industries and markets ... That revenue forecast appears in Ophthalmic Drugs: World Market Prospects 2012-2022, published in March 2012. Visiongain is a ...
Acute Macular Neuroretinopathy Following the Administration of an Influenza Vaccination Parth Shah, BSc; Jill S. Zaveri, MD; ... Ophthalmic Surgery, Lasers and Imaging Retina. 2018;49(10):e114-e121 https://doi.org/10.3928/23258160-20181002-13 ... Ophthalmic Surgery, Lasers and Imaging Retina. 2018;49(10):e122-e128 https://doi.org/10.3928/23258160-20181002-14 ... Ophthalmic Surgery, Lasers and Imaging Retina. 2018;49(10):e129-e134 https://doi.org/10.3928/23258160-20181002-15 ...
... it has been discovered that natural occurring compounds alone and in combination with chemical agents can be used in ophthalmic ... Absorption enhancers for drug administration. US5945446 *. 10 Feb 1997. 31 Aug 1999. Laubc Biochemicals, Corporation. Process ... Ophthalmic and contact lens solutions. US7067547 *. 4 Nov 2000. 27 Jun 2006. Fxs Ventures, Llc. Ophthalmic and contact lens ... Ophthalmic and contact lens solution. US20130079422 *. 16 Nov 2012. 28 Mar 2013. Fxs Ventures, Llc. Ophthalmic contact lens ...
The AMERICAN SOCIETY OF OPHTHALMIC PHYSICIAN ASSISTANTS covers Association services, namely, promoting the interests of ... AMERICAN SOCIETY OF OPHTHALMIC PHYSICIAN ASSISTANTS is a trademark and brand of American Society of Cataract and Refractive ... ophthalmic physician assistants in the field of ophthalmology. Search for other trademarks at Trademarkia. ... Class (035) - Advertising; business management; business administration; office functions. First Use Anywhere: Not provided. ...
Patient Administration Risk Management Resource Library - Ophthalmic Mutual Insurance Company. Comprehensive collection of loss ... Ophthalmic Surgical Task Force Surgery Checklist. Wrong Site/Wrong IOL Surgery Performance Improvement Course - American ... This paper outlines which patient safety incidents to report and analyze in ophthalmic practice and how to do so. ... Methods to reduce prescription errors in ophthalmic medication - Saudi Journal of Ophthalmology. The authors determined the ...
Ophthalmic Gel 0.5%. Drug: Loteprednol Etabonate Ocular administration of study drug. at least once within any indication of ... Ophthalmic suspension 0.5%. Drug: Prednisolone Acetate 1% Oph Susp Ocular administration of study drug. at least once within ... A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5%. This study is ongoing, but not recruiting ... A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5%. ...
Anti-Allergic Agents / administration & dosage * Anti-Allergic Agents / adverse effects * Anti-Allergic Agents / therapeutic ... Purpose: To evaluate loteprednol etabonate ophthalmic 0.5% suspension, versus placebo for treatment of the inflammatory ... A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, ...
today announced that the United States Food and Drug Administration ... Ophthalmic Solution IRVINE, Calif., May 19, 2010 (BUSINESS WIRE) -- Allergan, Inc. ... today announced that the United States Food and Drug Administration (FDA) has approved ZYMAXID(TM) (gatifloxacin ophthalmic ... DOSAGE AND ADMINISTRATION. Patients one year of age or older: Instill one drop every two hours in the affected eye(s) while ...
  • What is atropine sulfate ointment-ophthalmic, and how does it work (mechanism of action)? (medicinenet.com)
  • What brand names are available for atropine sulfate ointment-ophthalmic? (medicinenet.com)
  • Is atropine sulfate ointment-ophthalmic available as a generic drug? (medicinenet.com)
  • Do I need a prescription for atropine sulfate ointment-ophthalmic? (medicinenet.com)
  • What are the side effects of atropine sulfate ointment-ophthalmic? (medicinenet.com)
  • What is the dosage for atropine sulfate ointment-ophthalmic? (medicinenet.com)
  • Which drugs or supplements interact with atropine sulfate ointment-ophthalmic? (medicinenet.com)
  • Is atropine sulfate ointment-ophthalmic safe to take if I'm pregnant or breastfeeding? (medicinenet.com)
  • What else should I know about atropine sulfate ointment-ophthalmic? (medicinenet.com)
  • What preparations of atropine sulfate ointment-ophthalmic are available? (medicinenet.com)
  • How should I keep atropine sulfate ointment-ophthalmic stored? (medicinenet.com)
  • Orbenin Ophthalmic Eye Ointment is for the treatment of a range of bacterial infections in the eyes of cattle, sheep, horses, dogs and cats. (viovet.co.uk)
  • Orbenin Ophthalmic Eye Ointment 16.67% w/w is a sterile off-white, viscous stable suspension of Cloxacillin Benzathine in a non-irritant ophthalmic base with 3% aluminium stearate. (viovet.co.uk)
  • Orbenin Ophthalmic Eye Ointment is effective against a range of bacteria (including Moraxella spp. (viovet.co.uk)
  • The consistency of Orbenin Ophthalmic Eye Ointment ensures even distribution of ointment across the cornea and the conjunctival mucosae. (viovet.co.uk)
  • Terramycin Ophthalmic Ointment with Polymyxin B Sulfate is a suspension of oxytetracycline hydrochloride and polymyxin B sulfate in a special petrolatum base. (medi-vet.com)
  • Terramycin Ophthalmic Ointment with Polymyxin B Sulfate should be administered topically to the eye 2-4 times daily. (medi-vet.com)
  • Ophthalmic ointment (1% in 1g and 3.5 g sizes). (cdc.gov)
  • Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic Ointment is indicated for the treatment of superficial bacterial infections of the eyelid and conjunctiva in dogs and cats when due to organisms susceptible to the antibiotics contained in the ointment. (medi-vet.com)
  • The three antibiotics present in bacitracin-neomycin-polymyxin veterinary ophthalmic ointment provide a broad spectrum of activity against the gram-positive and gram-negative bacteria commonly involved in superficial infections of the eyelid and conjunctiva. (medi-vet.com)
  • The area should be properly cleansed prior to the use of Bacitracin-Neomycin-Polymyxin Veterinary Ophthalmic Ointment. (medi-vet.com)
  • Patients with burns to the cornea, conjunctiva, and sclera are usually treated with prophylactic topical administration of broad-spectrum ophthalmic antibiotic drops or ointment (eg, tobramycin, gentamicin, ciprofloxacin, norfloxacin, or bacitracin). (medscape.com)
  • Optimmune ® Ophthalmic Ointment Rx for Dogs is indicated for management of chronic keratoconjunctivitis sicca (KCS) and chronic superficial keratitis (CSK) in dogs. (lambertvetsupply.com)
  • Optimmune ® Ophthalmic Ointment Rx can increase natural tear production and reduce inflammation. (lambertvetsupply.com)
  • Cyclosporine (cyclosporin A), the active ingredient of Optimmune ® Ophthalmic Ointment Rx for Dogs, is a cyclic undecapeptide metabolite of the fungus Tolypocladium inflatum gams. (lambertvetsupply.com)
  • For best results in treating KCS, cyclosporine ophthalmic ointment should be administered early in the course of the disease before irreversible damage to the lacrimal tissue, or dense corneal scarring or pigmentation occurs. (lambertvetsupply.com)
  • Periodic reassessment of the need for Optimmune ® Ophthalmic Ointment Rx therapy is recommended. (lambertvetsupply.com)
  • Optimmune ® Ophthalmic Ointment Rx is available in a 3.5 g tube, carton of 6 (NDC 0061-1088-01). (lambertvetsupply.com)
  • The clinical effects of Optimmune ® Ophthalmic Ointment Rx have not been determined in dogs with KCS due to the following conditions: congenital alacrima, sulfonamide usage, canine distemper virus, metabolic disease, surgical removal of the third eyelid gland, and facial nerve paralysis with loss of the palpebral reflex. (lambertvetsupply.com)
  • Prednisolone acetate ophthalmic suspension, USP 1% is a sterile, topical anti-inflammatory agent for ophthalmic use. (nih.gov)
  • Prednisolone acetate ophthalmic suspension 1% is indicated for the treatment of steroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe. (nih.gov)
  • Prednisolone acetate ophthalmic suspension 1% is contraindicated in acute untreated purulent ocular infections, in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures. (nih.gov)
  • Prednisolone acetate ophthalmic suspension 1% is also contraindicated in individuals with known or suspected hypersensitivity to any of the ingredients of this preparation and to other corticosteroids. (nih.gov)
  • Prednisolone acetate ophthalmic suspension 1% contains sodium bisulfite, a sulfite that may cause allergic-type reactions, including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. (nih.gov)
  • The initial prescription and renewal of the medication order beyond 20 milliliters of prednisolone acetate ophthalmic suspension 1% should be made by a physician only after examination of the patient with the aid of magnification, such as slit lamp biomicroscopy, and, where appropriate, fluorescein staining. (nih.gov)
  • To evaluate loteprednol etabonate ophthalmic 0.5% suspension, versus placebo for treatment of the inflammatory component of keratoconjunctivitis sicca in patients with delayed tear clearance. (nih.gov)
  • Prednisolone Acetate Ophthalmic Suspension is a corticosteroid medication indicated for the treatment of steroid responsive inflammatory conditions in the eyes. (heartlandvetsupply.com)
  • Prednisolone Acetate Ophthalmic Suspension is prescribed to decrease inflammation due to conditions such as conjunctivitis (inflammation of the lining of the lids) and some types of keratitis (inflammation of the cornea). (heartlandvetsupply.com)
  • If discharge is present, the area should be cleansed with a sterile eyewash solution prior to applying Prednisolone acetate ophthalmic suspension. (heartlandvetsupply.com)
  • How does Prednisolone Acetate Ophthalmic Suspension work? (heartlandvetsupply.com)
  • PURPOSE: To compare emedastine ophthalmic solution 0.05% BID to levocabastine ophthalmic suspension 0.05% BID in reducing chemosis, eyelid swelling and other signs and symptoms in subjects with seasonal allergic conjunctivitis. (biomedsearch.com)
  • METHODS: In a randomized, double-masked, parallel controlled study, emedastine ophthalmic solution 0.05% BID was compared to levocabastine ophthalmic suspension 0.05% BID for control of chemosis, eyelid swelling and other parameters in the environmental allergy study model. (biomedsearch.com)
  • To assess the efficacy of nepafenac 0.1% ophthalmic suspension in improving the clinical outcomes following cataract surgery (CS) in patients with nonproliferative diabetic retinopathy. (dovepress.com)
  • Efficacy and safety of besifloxacin ophthalmic suspension 0.6% in children and adolescents with bacterial conjunctivitis: a post hoc, subgroup analysis of three randomized, double-masked, parallel-group, multicenter clinical trials. (medscape.com)
  • The efficacy of ZYMAXID(TM) ophthalmic solution was assessed in two multicenter, double-masked, randomized dual-arm comparison studies involving 1,437 patients receiving either ZYMAXID(TM) or vehicle. (fiercebiotech.com)
  • the average central retinal thickness decreased by 141.2 microns compared to baseline, and the efficacy of some patients lasted until 6 weeks after administration. (prnewswire.com)
  • Safety and efficacy comparison of emedastine 0.05% ophthalmic solution compared to levocabastine 0.0. (biomedsearch.com)
  • Efficacy and complications of super-selective intra-ophthalmic artery melphalan for the treatment of refractory retinoblastoma. (nih.gov)
  • Safety of Polyhexanide (PHMB) 0.08% ophthalmic solution after 26-week repeated-dose ocular administration in rabbits. (arvojournals.org)
  • These favourable results strengthen our plan to develop PHMB 0.08% ophthalmic solution as a novel orphan drug for the treatment of Acanthamoeba keratitis. (arvojournals.org)
  • To investigate the penetration of 0.3% gatifloxacin ophthalmic gel, 0.3% gatifloxacin ophthalmic solution and 0.5% levofloxacin ophthalmic solution into aqueous humor after topical application. (medsci.org)
  • Ophthalmic: Solution: Instill 1 drop of a 1% solution in the affected eye. (drugs.com)
  • XALATAN (latanoprost ophthalmic solution) 0.005% is supplied as a sterile, isotonic, buffered aqueous solution of latanoprost with a pH of approximately 6.7 and an osmolality of approximately 267 mOsmol/kg. (rxlist.com)
  • Sterile ophthalmic solution containing 50 mcg/mL latanoprost. (rxlist.com)
  • The following adverse reactions have been identified following use of atropine sulfate ophthalmic solution. (rxlist.com)
  • Eye pain and stinging occurs upon instillation of atropine sulfate ophthalmic solution. (rxlist.com)
  • In clinical studies, use of a single topical administration of atropine 1% ophthalmic solution (eye drops) resulted in maximal mydriasis (pupil dilation or widening) in approximately 40 minutes and maximal cycloplegia in approximately 60 to 90 minutes. (medicinenet.com)
  • For inducing mydriasis (pupil dilation) or cycloplegia in adults: Instill 1-2 drops of 1% ophthalmic solution in eye 1 hour before procedure. (medicinenet.com)
  • Atropine ophthalmic solution can be stored in the refrigerator or at room temperature away from heat and light. (medicinenet.com)
  • Xiidra ® (lifitegrast ophthalmic solution) 5% is indicated for the treatment of signs and symptoms of dry eye disease (DED). (xiidra-ecp.com)
  • Furthermore, it has been discovered that natural occurring compounds alone and in combination with chemical agents can be used in ophthalmic solutions such as contact lens solution to enhance and complement their anti-microbial, cleaning and wetting activity or to reduce irritation to the eye. (google.co.uk)
  • 14. The ophthalmic solution of claim 13 further comprising a viscosity altering agent. (google.co.uk)
  • 15. The ophthalmic solution of claim 13 further comprising a sequestering agent. (google.co.uk)
  • 16. The ophthalmic solution of claim 13 further comprising a wetting agent. (google.co.uk)
  • 17. The ophthalmic solution of claim 16, wherein the wetting agent comprising a saponin. (google.co.uk)
  • ZYMAXID(TM) is now the highest concentration gatifloxacin ophthalmic solution on the market in the United States. (fiercebiotech.com)
  • In clinical studies, ZYMAXID(TM) ophthalmic solution demonstrated a statistically superior eradication of bacterial conjunctivitis - approximately 90 percent (301/333) versus 70 percent (228/325) for vehicle (the recommended dosage is one drop every two hours in the affected eye(s) while awake, up to eight times on Day one and then two to four times daily while awake on Days two through seven). (fiercebiotech.com)
  • Allergan has a history of innovation in ocular anti-infective drugs dating back to OCUFLOX(R) ophthalmic solution in the early 1990s, and we are pleased to offer a new option to eye care professionals and their patients. (fiercebiotech.com)
  • Results of these studies demonstrated that at Day six, complete clearance of conjunctival hyperaemia and conjunctival discharge was achieved in 58 percent of patients (193/333) treated with ZYMAXID(TM) ophthalmic solution compared to 45 percent (148/325) in the vehicle group. (fiercebiotech.com)
  • [3] Tobrex is a 0.3% tobramycin sterile ophthalmic solution is produced by Bausch & Lomb Pharmaceuticals . (wikipedia.org)
  • An object of the present invention is to provide a composition which is excellent in safety and capable of dispersing uniformly on the mucous tissue when topically administered to mammals, and an ophthalmic solution comprising the composition and capable of stabilizing the tear film and keeping the tear film on the eyeball surface smooth. (freepatentsonline.com)
  • In a composition comprising a polysaccharide, particularly agar, and water as essential components, an ophthalmic solution comprising the agar-containing composition of which an amount of precipitated agar after performing centrifugal separation at with 40,000 ×g is less than 65 wt % of a total agar content has an excellent tear film stabilizing effect which was proved by a test on changes of corneal surface irregularity. (freepatentsonline.com)
  • Therefore, the agar-containing ophthalmic solution of the present invention has the effect of stabilizing the tear film on the eyeball surface over a prolonged period of time and is usable as an artificial tear fluid. (freepatentsonline.com)
  • Topical 1.5% azithromycin ophthalmic solution is an effective treatment option for chronic blepharitis. (scielo.br)
  • WHITEHOUSE STATION, N.J.--( BUSINESS WIRE )-- Merck (NYSE:MRK), known as MSD outside the United States and Canada, announced today that the U.S. Food and Drug Administration (FDA) has approved ZIOPTAN TM (tafluprost ophthalmic solution) 0.0015%, the first preservative-free prostaglandin analog ophthalmic solution. (fiercepharma.com)
  • CYSTADROPS is a viscous, or thick, cystine-depleting ophthalmic solution indicated for the treatment of corneal cystine crystal deposits in adults and children living with cystinosis. (biospace.com)
  • Rocklatan is supplied as a solution for topical ophthalmic administration. (centerwatch.com)
  • Cromolyn Sodium Ophthalmic Solution USP, 4% is a clear, colorless, sterile solution intended for topical ophthalmic use. (nih.gov)
  • When multiple doses of cromolyn sodium ophthalmic solution are instilled into normal rabbit eyes, less than 0.07% of the administered dose of cromolyn sodium is absorbed into the systemic circulation (presumably by way of the eye, nasal passages, buccal cavity and gastrointestinal tract). (nih.gov)
  • Cromolyn Sodium Ophthalmic Solution USP, 4% is indicated in the treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis. (nih.gov)
  • Cromolyn Sodium Ophthalmic Solution USP, 4% is contraindicated in those patients who have shown hypersensitivity to cromolyn sodium or to any of the other ingredients. (nih.gov)
  • MYDRIACYL ® (tropicamide ophthalmic solution, USP) is an anticholinergic prepared as a sterile topical ophthalmic solution in two strengths. (nih.gov)
  • The CoQun ® study is a multicenter, controlled trial aimed to evaluate the neuroprotective effects of Coqun ® , an ophthalmic solution of Coenzyme q10 (CoQ10) and Vitamin E (VitE), in patients affected by primary open-angle glaucoma (POAG). (springer.com)
  • BEPREVE (bepotastine besilate ophthalmic solution) 1.5% is a histamine H1 receptor antagonist indicated for the treatment of itching associated with allergic conjunctivitis. (bausch.com)
  • Integrated phase III trials of bepotastine besilate ophthalmic solution 1.5% for ocular itching associated with allergic conjunctivitis. (bausch.com)
  • It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery. (wikipedia.org)
  • Mobius Therapeutics™ has been awarded a supply agreement for Mitosol® (mitomycin for solution) Kit for Ophthalmic Use from HealthTrustSM. (prweb.com)
  • Paragon BioTeck, Inc., a privately held biopharmaceutical company specializing in the development of ophthalmic pharmaceuticals and therapies, today announced that the U.S. Food and Drug Administration has approved its New Drug Application (NDA) for Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5% and 10%, to dilate the pupil. (prweb.com)
  • Phenylephrine Hydrochloride Ophthalmic Solution has been marketed without FDA approval for decades, and during that time has been administered to millions of patients. (prweb.com)
  • Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5% and 10% is an alpha-1 adrenergic receptor agonist used for dilation of the pupil due to its vasoconstrictor and mydriatic action. (prweb.com)
  • Phenylephrine Hydrochloride Ophthalmic Solution, USP 10% is contraindicated in patients with hypertension or thyrotoxicosis, as well as in pediatric patients under the age of one due to the increased risk of systemic toxicity. (prweb.com)
  • Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5% should be used in these patients. (prweb.com)
  • The report provides value (USD million), volume (units) and average price (USD) data for each segment and sub-segment within seven market categories - Cataract Surgery Devices, Glaucoma Surgery Devices, Intraocular Lens (IOL), Ophthalmic Diagnostic Equipment, Refractive Surgery Devices, Vision Care and Vitreo Retinal Surgery Devices. (bio-medicine.org)
  • Market size and company share data for Ophthalmic Devices market categories - Cataract Surgery Devices, Glaucoma Surgery Devices, Intraocular Lens (IOL), Ophthalmic Diagnostic Equipment, Refractive Surgery Devices, Vision Care and Vitreo Retinal Surgery Devices. (bio-medicine.org)
  • The present invention relates to the use of thy1-FP (fluorescent protein) non-human transgenic animals such as mice to screen for ophthalmic agents that can be used to treat corneal dry eye syndrome and/or retinal neuropathies associated with glaucoma and/or age-related macular degeneration. (freepatentsonline.com)
  • The recommended frequency of administration should not be exceeded (see DOSAGE AND ADMINISTRATION ). (nih.gov)
  • The description provided to the USPTO for AMERICAN SOCIETY OF OPHTHALMIC PHYSICIAN ASSISTANTS is Association services, namely, promoting the interests of ophthalmic physician assistants in the field of ophthalmology . (trademarkia.com)
  • Ophthalmic Drugs will gather industry leaders to discuss the latest challenges and changes in the field of ophthalmology. (smi-online.co.uk)
  • These sources allow for a better appreciation of the how/why of ophthalmology and ophthalmic imaging today. (opsweb.org)
  • Ophthalmic Direct is our unique direct distribution channel for specialty ophthalmic products via our partnering network of ophthalmology clinics across Canada. (mckesson.ca)
  • In certain situations, Medical Assistants with no previous Ophthalmology or eye care experience may be offered both didactic and 'hands-on' clinical training so that within a reasonable time they will be able to demonstrate ophthalmic assistant skills and prepare for the COA and COT examinations and certifications. (seewithlasik.com)
  • 2001) (Although, it does respond to topical administration). (cdc.gov)
  • 2. A method according to claim 1, further comprising: initiating said systemic administration prior to said administration of topical cyclosporin, and discontinuing said systemic administration prior to discontinuing said topical administration. (google.com.au)
  • 3. A method according to claim 1, further comprising: initiating said systemic administration at a first dosage level prior to initiating said topical administration, and lowering said systemic dosage to a second level during said topical administration. (google.com.au)
  • It has been shown that administration of these prostaglandin drug products more than once daily may decrease the intraocular pressure ( IOP ) lowering effect or cause paradoxical elevations in IOP. (rxlist.com)
  • Tropicamide may interfere with the antihypertensive action of carbachol, pilocarpine, or ophthalmic cholinesterase inhibitors. (nih.gov)
  • NORTH BRUNSWICK, N.J.--( BUSINESS WIRE )-- Ascendia Pharmaceuticals , a specialty pharmaceutical company engaged in nano-formulation design, formulation, and manufacture of poorly soluble molecules, today announced that it has entered into a collaboration with KC Pharmaceuticals for the development of five over-the-counter (OTC) sterile ophthalmic drop medicines. (biospace.com)
  • 0.3% gatifloxacin ophthalmic gel application produced highest aqueous humor drug concentration, maintained the longest time, had the best penetration and bioavailability. (medsci.org)
  • Ding W, Ni W, Chen H, Yuan J, Huang X, Zhang Z, Wang Y, Yu Y, Yao K. Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% Gatifloxacin and 0.5% Levofloxacin Ophthalmic Solutions. (medsci.org)
  • The instillation of drops is the main route of ocular administration used for the treatment of diseases of the anterior segment. (scielo.br)
  • Facial support devices can improve the application of eye drops to promote: manual support for administration, better positioning of the bottle in relation to the eye, and easier to squeeze the bottle or keep the eyelids open. (scielo.br)
  • the pterygium and refractive indications are awaiting approval by the Food and Drug Administration. (prweb.com)
  • Written in response to a widely expressed need for greater clarity and consistency, this highly regarded book offers a comprehensive one-stop resource for all ophthalmic practitioners, whether they are registered nurses, healthcare assistants or ophthalmic technicians. (ellibs.com)
  • The OPS is the premier educational and training organization for ophthalmic imaging, serving ophthalmic technical personnel, photographers, physicians, and technicians alike. (opsweb.org)
  • Ophthalmic laboratory technicians are required to grind, cut, assemble, polish and inspect eye glasses, contact lenses and other related materials. (recruiter.com)
  • Ophthalmic Laboratory Technicians can earn salaries of Twenty Nine Thousand Six Hundred dollars yearly. (recruiter.com)
  • Ophthalmic Laboratory Technicians have the highest pay levels in Colorado, where they can get average wages of close to about $41280. (recruiter.com)
  • Recruiter makes it easy to find out about new jobs for ophthalmic laboratory technicians. (recruiter.com)
  • Our practices routinely offer career opportunities for Optometrists, Refractive Surgery Coordinators, Medical Assistants, Ophthalmic Technicians and LASIK Surgery Counselors interested in working with LASIK surgeons throughout the United States. (seewithlasik.com)
  • DUREZOL ™ (difluprednate ophthalmic emulsion) 0.05% is a topical ophthalmic corticosteroid for the treatment of postoperative inflammation and pain associated with ocular surgery. (businesswire.com)
  • Currently under clinical investigation to treat dry eye and other ocular surface diseases, ZYCLORIN™ is a topical ophthalmic immunomodulator and immunosuppressive agent. (businesswire.com)
  • As with other ophthalmic solutions containing benzalkonium chloride, soft contact lenses should not be worn during the treatment period. (medicines.org.uk)
  • 22, 2002 entitled "Ophthalmic Drug Delivery Device," which claims priority from U.S. Provisional Application No. 60/307,284 filed Jul. (google.com)
  • They were selected to start cyclosporine eye drop treatment, because of the prompt relapse of their disease as soon as they stopped topical corticosteroids administration. (biomedsearch.com)
  • ZYCLORIN™ (cyclosporine) is a topical ophthalmic immunomodulator and immunosuppressive agent. (businesswire.com)
  • ZIOPTAN is the first preservative-free prostaglandin analog," said David Michelson, M.D., vice president, Neurology and Ophthalmic Therapeutic Area, Merck Research Laboratories. (fiercepharma.com)
  • The market for ophthalmic drugs is expected to witness significant growth in the forthcoming years, as multiple manufacturers are increasingly focusing on R&D to develop innovative treatment. (grandviewresearch.com)
  • The players are engaging in extensive R&D activities to develop novel ophthalmic drugs for the treatment of various eye diseases and disorders and to gain a greater market share. (grandviewresearch.com)
  • For instance, in September 2014, Alimera Sciences Inc. received the Food and Drug Administration (FDA) approval for ILUVIEN, indicated for the treatment of DME. (grandviewresearch.com)
  • Coenzyme Q10 administration and its potential for treatment of neurodegenerative diseases. (springer.com)
  • Superselective ophthalmic artery chemotherapy as primary treatment for retinoblastoma (chemosurgery). (nih.gov)
  • Besifloxacin, a new ophthalmic fluoroquinolone for the treatment of bacterial conjunctivitis. (medscape.com)
  • Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. (wikipedia.org)
  • Contact lenses are regulated by the United States Food and Drug Administration (FDA). (wikipedia.org)
  • XALATAN may be used concomitantly with other topical ophthalmic drug products to lower IOP. (rxlist.com)
  • If more than one topical ophthalmic drug is being used, the drugs should be administered at least five (5) minutes apart. (rxlist.com)
  • Atropine ophthalmic is a drug used prior to eye exams or eye surgery. (medicinenet.com)
  • OPHTHALMIC (Phospholine Iodide) side effects, medical uses, and drug interactions. (medicinenet.com)
  • Drug delivery systems in ophthalmic therapy have undergone major technological advancements in the recent years. (grandviewresearch.com)
  • The strong growth is facilitated by a direct drug delivery mechanism as well impending launches of several ophthalmic solutions and suspensions in the next few years. (grandviewresearch.com)
  • It remains a large segment of the ophthalmic prescription drug market. (prnewswire.com)
  • Diabetic macular oedema (DME) will also be important to the future of the ophthalmic drug market. (prnewswire.com)
  • Ocular administration of study drug. (clinicaltrials.gov)
  • On May 9, 1985, the Center for Devices and Radiological Health (CDRH) of the Food and Drug Administration (FDA) issued a document entitled "New Procedures For Adding Lens Finishing Laboratories Through Supplements to Approved Premarket Approval Applications For Rigid Gas Permeable Contact Lenses. (fda.gov)
  • The Food and Drug Administration (FDA or Agency) is announcing a publication containing modifications the Agency is making to the list of standards FDA recognizes for use in premarket reviews (FDA Recognized Consensus Standards). (federalregister.gov)
  • All submissions received must include the Docket No. FDA-2004-N-0451 for "Food and Drug Administration Modernization Act of 1997: Modifications to the List of Recognized Standards, Recognition List Number: 051. (federalregister.gov)
  • Rocklatan may be used concomitantly with other topical ophthalmic drug products to lower IOP. (centerwatch.com)
  • In normal volunteers, analysis of drug excretion indicates that approximately 0.03% of cromolyn sodium is absorbed following administration to the eye. (nih.gov)
  • Topical ocular administration of Nepafenac achieved sufficient drug delivery to the retina and diabetes-induced alterations in retinal vascular metabolism, function, and morphology were inhibited. (diabetesjournals.org)
  • These results were communicated to the Food that may lead to vision loss or enucleation, is caused by and Drug Administration (FDA) and were rapidly dissemi the ubiquitous free-living Acanthamoeba spp. (cdc.gov)
  • An ophthalmic drug delivery device having a first end and a second end, an injection port, a reservoir, and a sleeve is disclosed. (google.com)
  • DUREZOL™ emulsion is a topical ophthalmic corticosteroid used to treat postoperative inflammation and pain associated with ocular surgery and received approval from the U.S. Food and Drug Administration (FDA) in 2008. (businesswire.com)
  • ZYCLORIN™ is an investigational drug and is not approved by the U.S. Food and Drug Administration. (businesswire.com)
  • KC Pharmaceuticals is a leading and trusted supplier in the private store brand category offering a full range of ophthalmic eye drop formulas and contact lens solutions. (biospace.com)
  • KC Pharmaceuticals, located in Pomona, California for the past 30 years, also offers industry leading contract ophthalmic product manufacturing services. (biospace.com)
  • Alcon, which has been dedicated to the ophthalmic industry for 65 years, researches, develops, manufactures and markets pharmaceuticals, surgical equipment and devices, contacts lens solutions and other vision care products that treat diseases, disorders and other conditions of the eye. (businesswire.com)
  • This new edition has been revised to make the text even clearer and bring all the guidance up to date, covering communication, visual acuity testing, ocular medications, the ophthalmic outpatient department, biometry, the ophthalmic accident and emergency department, the slit lamp and tonometry, additional standards using specific equipment, and suggested documentation for providing evidence of development and competence. (ellibs.com)
  • 1. Do you routinely administer ophthalmic anesthesia to patients like the one described above? (theexpertinstitute.com)
  • Agents that are commonly used in patients with ocular burns include cycloplegic mydriatics, ophthalmic antibiotics, analgesics, and toxoids. (medscape.com)
  • Coordinate the daily operations of the ship ophthalmic team responsible for pre-/post-operative assessment and care of ophthalmic surgical and medical patients. (christianjobs.com)
  • Patients with gonorrheal infections, neonates with infections, and patients who are immunocompromised should be admitted for administration of intravenous antibiotics. (medscape.com)
  • Ciprofloxacin ophthalmic is a bactericidal antibiotic that inhibits bacterial DNA synthesis and, consequently, growth by inhibiting DNA-gyrase in susceptible organisms. (medscape.com)
  • An ever-increasing proportion of ophthalmic surgery, especially cataract surgery, is performed under local anesthesia (LA). Of all injection LA techniques, sub-Tenon's block (STB) has gained increasing popularity. (lww.com)
  • Tobramycin ophthalmic interferes with bacterial protein synthesis by binding to 30S and 50S ribosomal subunits, resulting in a defective bacterial cell membrane. (medscape.com)
  • Adverse events were observed following systemic administration of gentamicin in animal reproduction studies. (drugs.com)
  • Ophthalmic (tobramycin only, Tobrex, or combined with dexamethasone , sold as TobraDex) and nebulised formulations both have low systemic absorption . (wikipedia.org)
  • for Bepotastine Besilate Ophthalmic Solutions Study Group. (bausch.com)
  • Mobius Therapeutics™ is a commercial stage venture focused on ophthalmic surgery solutions. (prweb.com)
  • Moreover, besides the logistical problems associated with using topicals, there are also systemic side effects which result from the administration of some drugs used to combat the pathological states of the eye. (wikipedia.org)
  • The global ophthalmic drugs market size was valued at USD 31.0 billion in 2019 and is expected to expand at a CAGR of 5.0% from 2019 to 2027. (grandviewresearch.com)
  • In 2019, retinal disorders segment dominated the ophthalmic drugs market owing to increasing prevalence of age-related macular degeneration and diabetic retinopathy. (grandviewresearch.com)
  • The OTC segment is positioned to demonstrate a strong growth rate, driven by the loss of patent exclusivities of major drugs and consequent rise in generic penetration of ophthalmic drugs. (grandviewresearch.com)
  • A new report by visiongain predicts that the world market for ophthalmic drugs will reach $18.7 billion for 2012. (prnewswire.com)
  • Many commercial opportunities for ophthalmic drugs exist, with high revenues possible this decade. (prnewswire.com)
  • Dr Syed Ahmed , a senior pharmaceutical industry analyst at visiongain, said, 'The world market for ophthalmic drugs is an important segment of the pharma industry. (prnewswire.com)
  • Ophthalmic Drugs: World Market Prospects 2012-2022 adds to visiongain's range of analytical reports on industries and markets in healthcare. (prnewswire.com)
  • SMi Group are thrilled to present the launch of Ophthalmic Drugs conference taking place on 28th & 29th November in London, UK. (smi-online.co.uk)
  • Ophthalmic Laboratory Technician Salary: Latest Wage and Compensation Trends in Your Area. (recruiter.com)
  • An Ophthalmic Laboratory Technician can earn a pay level between 16000 - 24000 based on experience. (recruiter.com)
  • Are you an aspiring ophthalmic laboratory technician? (recruiter.com)
  • Create your free ophthalmic laboratory technician job alert today and take control of your future. (recruiter.com)
  • To overlay local salaries for an Ophthalmic Laboratory Technician, please select your state. (recruiter.com)
  • The skills you learn will help prepare you for a career as an optical laboratory technician, an optician or an ophthalmic laboratory technician in optical laboratories or retail optical offices. (goarmy.com)
  • Medical Assistant/Certified Ophthalmic Assistant (C.O.A.) /Certified Ophthalmic Technician (C.O.T. (seewithlasik.com)
  • Or, contact the owner American Society of Cataract and Refractive Surgery of the AMERICAN SOCIETY OF OPHTHALMIC PHYSICIAN ASSISTANTS trademark by filing a request to communicate with the Legal Correspondent for licensing, use, and/or questions related to the AMERICAN SOCIETY OF OPHTHALMIC PHYSICIAN ASSISTANTS trademark. (trademarkia.com)
  • Thought you might appreciate this item(s) I saw at Ophthalmic Plastic & Reconstructive Surgery. (lww.com)
  • An intravenous administration set assembly (10) is disclosed which is capable of introducing fluid from a plurality of sources of intravenous fluids into a patient and which allows the various sources of fluid to be easily attached and detected from the assembly without the necessity for intravening. (google.com.au)
  • An intravenous administration set assembly (10) is disclosed which is capable of introducing fluid from a plurality of sources of intravenous fluids into a patient and which allows the various sources of fluid to be easily attached and detected from the assembly without the necessity for intravening safety steps, such as purging the system, and yet without any possibility of air or bacteria being introduced through the system into the patient. (google.com.au)
  • 2. An intravenous administration set assembly as claimed in claim 1 wherein the tubing means (38, 46, 56) connected between the air-eliminating filter (32) and the adapter (58) includes at least one fitting (52) having an injection site (54) provided therein so that injections of medication to the patient can easily be made in the course of intravenous administrations of fluid to a patient. (google.com.au)
  • 3. An intravenous administration set assembly as claimed in claim 2 wherein the tubing means (38, 46, 56) further includes a second fitting (40) having an inlet adapter (43) provided thereon which is capable of being locked to a source of biological fluid for introduction to a patient which may not pass through an air-eliminating filter. (google.com.au)
  • Provide direction for procurement of supplies and equipment needed for outpatient ophthalmic care, working to simplify and standardize requirements. (christianjobs.com)
  • Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis. (nih.gov)
  • In infants, the preferred site of administration is the midthigh laterally. (medscape.com)
  • Scopolamine ophthalmic blocks the action of acetylcholine at parasympathetic sites in smooth muscle, producing pupillary dilation (mydriasis) and paralysis of accommodation (cycloplegia). (medscape.com)
  • and both immediate-release and controlled-release products for oral administration. (biospace.com)
  • Write a review about a product or service associated with this AMERICAN SOCIETY OF OPHTHALMIC PHYSICIAN ASSISTANTS trademark. (trademarkia.com)
  • On Tuesday, January 13, 2015, a U.S. federal trademark registration was filed for AMERICAN SOCIETY OF OPHTHALMIC PHYSICIAN ASSISTANTS. (trademarkia.com)
  • LegalForce Network can help you incorporate a business around your AMERICAN SOCIETY OF OPHTHALMIC PHYSICIAN ASSISTANTS trademark in less than 5 minutes. (trademarkia.com)
  • This handbook of ophthalmic nursing standards and procedures has been developed to assist healthcare professionals working in a wide range of ophthalmic settings, and also to provide the patient with safe and consistent ophthalmic nursing care. (ellibs.com)