AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHealth CareGeographicals
Administration, OralDrug Administration ScheduleInjections, IntravenousUnited States Food and Drug AdministrationDrug Administration RoutesDose-Response Relationship, DrugRats, Sprague-DawleyTime FactorsAdministration, IntranasalRats, WistarInjections, IntraperitonealDisease Models, AnimalInjections, SubcutaneousAdministration, RectalLiverMice, Inbred C57BLBiological AvailabilityInjections, IntramuscularAdministration, TopicalInfusions, IntravenousHalf-LifeAdministration, IntravenousDrug InteractionsArea Under CurveInjections, IntraventricularMice, Inbred BALB CRats, Inbred StrainsAdministration, CutaneousTissue DistributionDogsDouble-Blind MethodCross-Over StudiesTreatment OutcomeBlood PressureAdministration, SublingualBrainAdministration, InhalationKidneyInfusions, ParenteralBody WeightRandom AllocationBehavior, AnimalDrug ToleranceMorphineRecombinant ProteinsPlant ExtractsInjectionsAnalysis of VarianceInjections, SpinalOrgan SizeMetabolic Clearance RateChromatography, High Pressure LiquidRNA, MessengerRabbitsMice, Inbred ICRLungRats, Inbred F344Analgesics, OpioidSelf AdministrationEthanolHeart RatePregnancyEstradiolMotor ActivityAntineoplastic AgentsDrug CombinationsMice, KnockoutHemodynamicsMice, Inbred StrainsDrug Evaluation, PreclinicalAnalgesicsDrug Therapy, CombinationEnzyme InhibitorsInjections, Intra-ArterialAdministration, BuccalSpleenPiperidinesProdrugsAntibodies, MonoclonalIntestinal AbsorptionBlood GlucoseDrug ApprovalAnti-Inflammatory Agents, Non-SteroidalDrug SynergismCocaineNaloxoneEatingUnited StatesDopamineGenetic TherapyNitric OxideCytokinesHydrocortisoneAbsorptionCells, CulturedLipopolysaccharidesImmunohistochemistryDelayed-Action PreparationsInsulinPain Measurement
Administration, Oral
The giving of drugs, chemicals, or other substances by mouth.
Drug Administration Schedule
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Injections, Intravenous
Injections made into a vein for therapeutic or experimental purposes.
United States Food and Drug Administration
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Drug Administration Routes
The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Rats, Sprague-Dawley
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Administration, Intranasal
Delivery of medications through the nasal mucosa.
Rats, Wistar
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Injections, Intraperitoneal
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
Disease Models, Animal
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Injections, Subcutaneous
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
Administration, Rectal
The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.
Liver
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Mice, Inbred C57BL
Biological Availability
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
Injections, Intramuscular
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Infusions, Intravenous
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Half-Life
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Administration, Intravenous
Delivery of substances through VENIPUNCTURE into the VEINS.
Drug Interactions
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Area Under Curve
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Injections, Intraventricular
Injections into the cerebral ventricles.
Mice, Inbred BALB C
Rats, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Administration, Cutaneous
The application of suitable drug dosage forms to the skin for either local or systemic effects.
Tissue Distribution
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Dogs
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Double-Blind Method
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Cross-Over Studies
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Blood Pressure
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Administration, Sublingual
Administration of a soluble dosage form by placement under the tongue.
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Administration, Inhalation
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Kidney
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Infusions, Parenteral
The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Random Allocation
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Behavior, Animal
The observable response an animal makes to any situation.
Drug Tolerance
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
Morphine
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
Recombinant Proteins
Proteins prepared by recombinant DNA technology.
Plant Extracts
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Injections
Introduction of substances into the body using a needle and syringe.
Analysis of Variance
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Injections, Spinal
Introduction of therapeutic agents into the spinal region using a needle and syringe.
Organ Size
The measurement of an organ in volume, mass, or heaviness.
Metabolic Clearance Rate
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
Chromatography, High Pressure Liquid
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Rabbits
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Mice, Inbred ICR
Lung
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Rats, Inbred F344
Analgesics, Opioid
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Self Administration
Administration of a drug or chemical by the individual under the direction of a physician. It includes administration clinically or experimentally, by human or animal.
Ethanol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Heart Rate
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Estradiol
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Motor Activity
The physical activity of a human or an animal as a behavioral phenomenon.
Antineoplastic Agents
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Drug Combinations
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Hemodynamics
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Drug Evaluation, Preclinical
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Analgesics
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Drug Therapy, Combination
Therapy with two or more separate preparations given for a combined effect.
Enzyme Inhibitors
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Injections, Intra-Arterial
Delivery of drugs into an artery.
Administration, Buccal
Administration of a soluble dosage form between the cheek and gingiva. It may involve direct application of a drug onto the buccal mucosa, as by painting or spraying.
Spleen
An encapsulated lymphatic organ through which venous blood filters.
Piperidines
A family of hexahydropyridines.
Prodrugs
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
Antibodies, Monoclonal
Antibodies produced by a single clone of cells.
Intestinal Absorption
Uptake of substances through the lining of the INTESTINES.
Blood Glucose
Glucose in blood.
Drug Approval
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Drug Synergism
The action of a drug in promoting or enhancing the effectiveness of another drug.
Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Naloxone
A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
Eating
The consumption of edible substances.
United States
Dopamine
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Genetic Therapy
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Nitric Oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Hydrocortisone
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
Absorption
The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Lipopolysaccharides
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Immunohistochemistry
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Delayed-Action Preparations
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Pain Measurement
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Testosterone
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Anti-Inflammatory Agents
Substances that reduce or suppress INFLAMMATION.
Anti-Bacterial Agents
Substances that reduce the growth or reproduction of BACTERIA.
Microdialysis
A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.
Dexamethasone
An anti-inflammatory 9-fluoro-glucocorticoid.
Progesterone
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Genetic Vectors
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Growth Hormone
A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
Administration, Intravaginal
The insertion of drugs into the vagina to treat local infections, neoplasms, or to induce labor. The dosage forms may include medicated pessaries, irrigation fluids, and suppositories.
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Animals, Newborn
Refers to animals in the period of time just after birth.
Antioxidants
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Body Temperature
The measure of the level of heat of a human or animal.
Models, Animal
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Drug Delivery Systems
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Narcotic Antagonists
Agents inhibiting the effect of narcotics on the central nervous system.
Kinetics
The rate dynamics in chemical or physical systems.
Bile
An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.
United States Department of Veterans Affairs
A cabinet department in the Executive Branch of the United States Government concerned with overall planning, promoting, and administering programs pertaining to VETERANS. It was established March 15, 1989 as a Cabinet-level position.
Gonadotropin-Releasing Hormone
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
Phytotherapy
Use of plants or herbs to treat diseases or to alleviate pain.
Drugs, Chinese Herbal
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
Vasodilator Agents
Drugs used to cause dilation of the blood vessels.
Pyridines
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
Luteinizing Hormone
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Diabetes Mellitus, Experimental
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Piperazines
Neoplasms, Experimental
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Prospective Studies
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Mice, Nude
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Device Approval
Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.
Mice, Transgenic
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Neoplasm Transplantation
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Infusion Pumps
Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.
Pyrazoles
Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.
Glucocorticoids
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Regional Blood Flow
The flow of BLOOD through or around an organ or region of the body.
Methamphetamine
A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.
Serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Norepinephrine
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Diazepam
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
Corticosterone
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Anesthesia
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
Chemistry, Pharmaceutical
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
Adrenocorticotropic Hormone
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Drug Carriers
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Central Nervous System Stimulants
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
Ovariectomy
The surgical removal of one or both ovaries.
Hyperalgesia
An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Neuroprotective Agents
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Mice, Inbred C3H
Leukocyte Count
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
Hypnotics and Sedatives
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
Gene Expression
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Analgesics, Non-Narcotic
A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.
Intestines
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
Haloperidol
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
Drug-Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Imidazoles
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
Anti-Anxiety Agents
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
Indomethacin
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
Brain Chemistry
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Placebos
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
Suppositories
Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
Hypothalamus
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
Gene Expression Regulation
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Substance Withdrawal Syndrome
Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
Adenoviridae
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
Iodine Radioisotopes
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Neurons
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Nitric Oxide Synthase
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Infusion Pumps, Implantable
Implanted fluid propulsion systems with self-contained power source for providing long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristatically controlled with the aid of transcutaneous monitoring.
Chorionic Gonadotropin
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
Feces
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Blotting, Western
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Narcotics
Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.
Oxidative Stress
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Clinical Trials as Topic
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Erythropoietin
Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.
Acute Disease
Disease having a short and relatively severe course.
Hypoglycemic Agents
Substances which lower blood glucose levels.
Rats, Inbred Lew
Endotoxins
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
Sheep
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Immunoglobulin G
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Myocardium
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Nicotine
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Sulfonamides
A group of compounds that contain the structure SO2NH2.
Amphetamine
A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
Injections, Intradermal
The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.
Corpus Striatum
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
Intestinal Mucosa
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Indoles
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.

Recent advances in ophthalmic drug delivery. (1/59)

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Using fewer animals to identify chemical eye hazards: revised criteria necessary to maintain equivalent hazard classification. (2/59)

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Distribution of propranolol in periocular tissues: a comparison of topical and systemic administration. (3/59)

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The relationship between glaucoma medication adherence, eye drop technique, and visual field defect severity. (4/59)

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Polymeric vectors for ocular gene delivery. (5/59)

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Brimonidine tartrate-eudragit long-acting nanoparticles: formulation, optimization, in vitro and in vivo evaluation. (6/59)

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The effect of dorzolamide 2% on circadian intraocular pressure in cats with primary congenital glaucoma. (7/59)

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Effects of unilateral topical administration of 0.5% tropicamide on anterior segment morphology and intraocular pressure in normal cats and cats with primary congenital glaucoma. (8/59)

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Sustained Release Ocular Drug Delivery Systems Market Overview 2018 | Trade CallsSustained Release Ocular Drug Delivery Systems Market Overview 2018 | Trade Calls
This independent 125 pages report guarantees you will remain better informed than your competition. With over 170 tables and figures examining the Sustained Release Ocular Drug Delivery Systems market, the report gives you a visual, one-stop breakdown of the leading products, submarkets and market leaders market revenue forecasts as well as analysis to 2025.. The report provides a basic overview of the Sustained Release Ocular Drug Delivery Systems industry including definitions, classifications, applications and industry chain structure. And development policies and plans are discussed as well as manufacturing processes and cost structures.. Primary sources are mainly industry experts from core and related industries, and suppliers, manufacturers, distributors, service providers, and organizations related to all segments of the industrys supply chain. The bottom-up approach was used to estimate the Global market size of Sustained Release Ocular Drug Delivery Systems Market based on end-use ...
http://www.tradecalls.org/2018-02-12-sustained-release-ocular-drug-delivery-systems-market
Treatise on Ocular Drug DeliveryTreatise on Ocular Drug Delivery
A multidisciplinary approach is increasingly being adapted by the Pharmaceutical industry to tackle several challenges in developing efficacious treatment solutions. The field of Ophthalmology is no less different. Treatise on Ocular Drug Delivery is a unique collection of information put together by various experts in the field. One of the major goals behind this volume is to link clinical information with the current strategies employed in ocular drug delivery. This monograph covers a range of topics on ocular pharmacology. Chapters in the e-book cover several aspects of drug delivery research such as the biochemical background of specific eye diseases, challenges for ocular drug delivery, the role of influx and efflux transporters, novel drug delivery systems, pharmacokinetics, regulatory aspects, and patenting opportunities for researchers. This E-Book would serve as a suitable reference for pharmacy graduates, medical students, professional scientists and ophthalmic clinicians in academic ...
https://benthambooks.com/book/9781608051755/
Ocular drug deliveryOcular drug delivery
Various efforts in ocular drug delivery have been made to improve the bioavailability and to prolong the residence time of drugs applied topically onto the eye. . The present presentation includes | Basics of drug delivery systems | General aspects for design and development of DDS | General concepts of ocular drug delivery routes | various pros and cons of ocular drug therapy
http://www.pharmainfo.net/pppc08/ocular-drug-delivery
Role of Membrane Transporters and Metabolizing Enzymes in Ocular Drug Delivery | Bentham ScienceRole of Membrane Transporters and Metabolizing Enzymes in Ocular Drug Delivery | Bentham Science
Title:Role of Membrane Transporters and Metabolizing Enzymes in Ocular Drug Delivery. VOLUME: 15 ISSUE: 7. Author(s):Ramya Krishna Vadlapatla, Aswani Dutt Vadlapudi, Dhananjay Pal and Ashim K. Mitra. Affiliation:University of Missouri- Kansas City, School of Pharmacy, 2464 Charlotte Street, Kansas City, MO 64108-2718, USA.. Keywords:Age-related eye diseases, drug delivery, membrane transporters, metabolizing enzymes, pharmacodynamic, pharmacokinetic and tissue localization.. Abstract:Ocular disorders can significantly lower a patients quality of life. Centers for Disease Control and Preventions Vision Health Initiative have estimated that the number of people affected by age-related ocular diseases may be doubled in the United States by 2030. Although availability of newer therapeutics has improved the prognosis of ocular diseases, poor ocular bioavailability still remains a major concern. Combinations of pharmacodynamic and pharmacokinetic barriers have been known to determine the amount of ...
https://www.eurekaselect.com/124932/article?tracking-code=4
Formulation Approaches for Ocular Drug Delivery | SpringerLinkFormulation Approaches for Ocular Drug Delivery | SpringerLink
This chapter aims to provide the readers a comprehensive review of the current trends and approaches used in the development of ocular drug delivery systems. After the introduction to the topic, the c
https://link.springer.com/chapter/10.1007%2F978-3-319-29346-2_8
Get PDF - Development and optimization of solid lipid nanoparticle formulation for ophthalmic delivery of chloramphenicol using...Get PDF - Development and optimization of solid lipid nanoparticle formulation for ophthalmic delivery of chloramphenicol using...
Hao, J.; Fang, X.; Zhou, Y.; Wang, J.; Guo, F.; Li, F.; Peng, X., 2011: Development and optimization of solid lipid nanoparticle formulation for ophthalmic delivery of chloramphenicol using a Box-Behnken design
https://eurekamag.com/research/052/546/052546713.php
Development of a Δ9-Tetrahydrocannabinol Amino Acid-Dicarboxylate Prodrug With Improved Ocular Bioavailability | IOVS | ARVO...Development of a Δ9-Tetrahydrocannabinol Amino Acid-Dicarboxylate Prodrug With Improved Ocular Bioavailability | IOVS | ARVO...
Prostaglandin derivatives, parasympathomimetics, β blockers, and carbonic anhydrase inhibitors are the major drug classes that are used in the management of glaucoma.4,5 Prostaglandin derivatives, such as latanoprost and bimatoprost, increase the aqueous humor (AH) outflow through the uveoscleral pathway. Several mechanisms have been proposed to explain how prostaglandin derivatives reduce the IOP. Relaxation of the ciliary muscles, which causes the connective tissue-filled spaces in the trabecular meshwork to widen, is thought to be a factor that is involved in the initial drop in IOP.6 Prostaglandin analogs also induce the release of matrix metalloproteinase enzymes and cause the dissolution of types I and III collagen within the connective tissue-filled spaces.7 This process also leads to an increase in the AH outflow through the trabecular meshwork. Pilocarpine is a direct-acting cholinergic parasympathomimetic agent. It directly stimulates the muscarinic receptors and smooth muscles of the ...
http://iovs.arvojournals.org/article.aspx?articleid=2618507
Topical Ocular Drug Delivery to the Back of the Eye by Mucus-Penetrating Particles | TVST | ARVO JournalsTopical Ocular Drug Delivery to the Back of the Eye by Mucus-Penetrating Particles | TVST | ARVO Journals
A topical dose of LE-MPP (35 μL) was administered in the right eye of 5- to 6-month-old female Gottingen mini-pigs (Marshall Farms USA, Inc., North Rose, NY) approximately 6 hours apart (± 20 minutes), for 4 consecutive days. On the fifth day, animals were administered only two doses, approximately 6 hours apart (±20 minutes). A total of 18 doses were administered over the study duration. The dose was administered on the top of the cornea via a calibrated positive displacement micropipette and allowed to distribute across the eye. Each animal was restrained for approximately 1 minute to prevent rubbing of the eyes. Any observed irregularities or local irritation were recorded. Three animals/time point were euthanized with sodium pentobarbital and blood was collected via cardiac puncture at 0.5, 1, and 2 hours after the last dose on day 5. Blood (approximately 10 mL) was collected into tubes containing K2EDTA and samples were maintained on wet ice until centrifuged to obtain plasma. All plasma ...
http://tvst.arvojournals.org/article.aspx?articleid=2326860
Ocular drug delivery - Dr. Rupak K. Banerjee
Severe vision loss from vitreoretinal (VR) diseases such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), intraocular lymphoma (IOL), uveitis and proliferative retinopathy (PVR ) accounts for most cases of irreversible ocular diseases world-wide. Existing therapeutic procedures for treatment of VR diseases are limited as: 1) systemic drug therapy administered through mouth or injected into the bloodstream, and topical administration such as eye drops, fail to penetrate the physiological barriers; 2) intravitreal injections can lead to uneven drug distribution causing increased toxicity for non-target ocular tissues; and 3) in comparison to lipophilic (not water soluble) drugs, sustained release devices for hydrophilic (water soluble) drugs for treating VR diseases are difficult to fabricate, as these hydrophilic drugs do not bind well with existing FDA approved lipophilic materials. At present, research is being conducted in developing a novel polymer-based biodegradable ...
http://www.min.uc.edu/rbanerje/Research_areas/drug-delivery-mass-transport/ocular-drug-delivery
Cubosomes and other potential ocular drug delivery vehicles for macromolecular therapeuticsCubosomes and other potential ocular drug delivery vehicles for macromolecular therapeutics
INTRODUCTION: Many macromolecular therapeutics designed to treat posterior segment eye diseases (PSEDs) are administered through frequent ocular injec
https://findanexpert.unimelb.edu.au/scholarlywork/958778-cubosomes-and-other-potential-ocular-drug-delivery-vehicles-for-macromolecular-therapeutics
Educational Network in Ocular Drug Delivery and Therapeutics | OcuTher Project | H2020 | CORDIS | European CommissionEducational Network in Ocular Drug Delivery and Therapeutics | OcuTher Project | H2020 | CORDIS | European Commission
H2020,OcuTher,MSCA-ITN-2016,20MED THERAPEUTICS BV(NL),CERTARA UK LIMITED(UK),UNIVERSITE DE STRASBOURG(FR),Vasgen Limited(UK),UNIVERSITA DEGLI STUDI DI PADOVA(IT),Retina International(CH),THE QUEENS UNIVERSITY OF BELFAST(UK),UNIVERSIDAD COMPLUTENSE DE MADRID(ES),DELSITECH OY(FI),OZ BIOSCIENCES SAS(FR),SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH(PL),Bio-Ker s.r.l(IT),INNOCORE TECHNOLOGIES BV(NL),BAYER AKTIENGESELLSCHAFT(DE),UNIVERSITEIT UTRECHT(NL),EBERHARD KARLS UNIVERSITAET TUEBINGEN(DE),TECHNISCHE UNIVERSITEIT EINDHOVEN(NL),ITA-SUOMEN YLIOPISTO(FI)
https://cordis.europa.eu/project/id/722717/results
Bio-Medical Materials and Engineering - Volume 7, issue 5 - Journals - IOS PressBio-Medical Materials and Engineering - Volume 7, issue 5 - Journals - IOS Press
Authors: Otsuka, Makoto , Nakahigashi, Yoshinori , Matsuda, Yoshihisa , Kokubo, Tadashi , Yoshihara, Satoru , Fujita, Hiroshi , Nakamura, Takashi Article Type: Research Article Abstract: The in vivo and in vitro drug release profiles from a self-setting bioactive CaO-SiO2 -P2 O5 glass bone cement containing indomethacin as a model drug were investigated. The cement containing 2% and 5% indomethacin (IMC) powder hardened within 5 min after mixing with ammonium phosphate buffer. After setting, in vitro drug release from drug-loaded cement pellets in a simulated body fluid (SBF) at pH 7.25 and 37°C continued for two weeks. The hardened cement gradually formed low-crystallinity hydroxyapatite during the drug release test in SBF. An IMC-loaded cement device (2% and 5% drug) was implanted in the subcutaneous tissue …on the back of rats. The in vivo IMC release from the cement increased and attained maximum levels (Cmax of 2% and 5% drug-loaded cements was 0.27 and 3.37 μg/ml, respectively) at Tmax ...
https://content.iospress.com/journals/bio-medical-materials-and-engineering/7/5
Phenylephrine Acid Tartrate and breastfeeding. Are they compatible?Phenylephrine Acid Tartrate and breastfeeding. Are they compatible?
A sympathomimetic with alpha-adrenergic activity. It produces peripheral vasoconstriction and increased blood pressure without stimulating effects on the central nervous system. Used as a decongestant in topical nasal preparations at low concentrations, associated with other drugs, in oral preparations to treat respiratory colds (Nice 2000, Kanfer 1993) and in eye drops at concentrations of up to 10% as a mydriatic. It is also used subcutaneously or intramuscularly in severe hypotensive states and associated with topical anesthetics. Since the last update we have not found published data on its excretion in breastmilk. The low dose of phenylephrine in nasal, ophthalmic and topical preparations makes it unlikely to transfer into breastmilk in significant amounts. It is advised to press on the tear duct after administering eye drops in order to decrease absorption. Low plasma concentrations have been recorded at 10 minutes after ophthalmic administration and practically zero at one hour (AEMPS
http://e-lactancia.org/breastfeeding/phenylephrine-acid-tartrate/synonym/
Asian Journal of Pharmacy and Technology
Eye drops are the most acceptable dosage form by ocular route, which as has disadvantage of bioavailability. The anatomical and physiological constrains limited permeability of drug such as drug loss from the ocular surface by lachrymal drainage, blood-ocular barriers. A number of drug delivery system has been developed to improve the bioavailability and to prolong the residence time of drugs on the eye. Such as promising system for ocular drug delivery is a microemulsion. Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. This review gives an overview of the potential of microemulsions as delivery vehicles for eye. Both lipophilic and hydrophilic characteristics are present in microemulsions, so that the loaded drugs can diffuse passively as well get significantly partitioned in the variable lipophilic-hydrophilic corneal barrier.
https://ajptonline.com/AbstractView.aspx?PID=2014-4-3-5
Microorganisms - a world in a hanging dropMicroorganisms - a world in a hanging drop
Do all microorganisms look the same? Can they move and change shape? What do they feed on? How small are they . . . and are they actually alive? This activities looks microorganisms under a microscope using the hanging drop technique.
http://www.saps.org.uk/secondary/teaching-resources/298-microorganisms-a-world-in-a-hanging-drop
Data Availability StatementAll relevant data are inside the paper - THE PRESENT STUDY AIMED TO ELUCIDATE THE CONSEQUENCES OF...Data Availability StatementAll relevant data are inside the paper - THE PRESENT STUDY AIMED TO ELUCIDATE THE CONSEQUENCES OF...
Data Availability StatementAll relevant data are inside the paper. and is also important in the context of numerous applications including, e.g., cells executive, disease modeling and drug screening platforms [1C3]. The structure and size of the related scaffolds vary in a broad range from two-dimensional (2D) arrays of sub-millimeter wells to complex 3D constructions aiming at mimicking specific organs [2, 3]. Chemically, the scaffolds are often fabricated by using natural hydrogels [2], synthetic polymers [1], or combination of such materials [4]. Cells growing in scaffolds typically aggregate. The morphology and form of aggregates could be different, depending on several factors like the cell type, style of a scaffold as well as the matching fabrication materials [1]. Cellular spheroids signify the most frequent form of cell set up [5, 6]. Aggregates of the shape were made, e.g., by concave microwell technique [7], dangling drop technique [5, 8], or rotating-wall vessel technique [9, 10]. The ...
http://www.woofahs.com/2021/03/07/%EF%BB%BFdata-availability-statementall-relevant-data-are-inside-the-paper-2/
Publications | Himanshu Gupta`s BlogPublications | Himanshu Gupta`s Blog
Publications & Citations Citations record http://scholar.google.com/citations?user=f6RQgCAAAAAJ&hl=en Papers Published in Indexed Journals Himanshu Gupta, Sanyog Jain, Rashi Mathur, A.K. Mishra, Pushpa Mishra, T.Velpandian, Sustained ocular drug delivery from a temperature and pH triggered in-situ gel system, Drug Delivery 14(8) 2007, 507-515. Himanshu Gupta, M. Aqil, R.K. Khar, Asgar Ali, Aseem Bhatnagar, Gaurav Mittal, Sanyog Jain. Development…
https://hgupta2.wordpress.com/publications/
TALLC Corporation announces grant of new SmartCelle patent for enhanced ocular delivery of TA-A001TALLC Corporation announces grant of new SmartCelle patent for enhanced ocular delivery of TA-A001
TALLC Corporation Inc., a pioneering pharmaceutical company using proprietary new molecular entities to treat acute and chronic inflammation, has been granted patent GB2561009 from the United Kingdom
https://news.lifesciencenewswire.com/newsroom/pharma/tallc-corporation-announces-grant-of-new-smartcelle-patent-for-enhanced-ocular-delivery-of-ta-a001
Ocular Drug Delivery Technology Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2017 - 2025 -...
The Report Ocular Drug Delivery Technology Market - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2017 - 2025 provides information on pricing, market analysis, shares, forecast, and company profiles for key industry participants. - MarketResearchReports.biz. This report on the Global Ocular Drug Delivery Technology market analyzes the current and future scenario of the global market. Rise in private and public funding for R&D of novel drug delivery technologies, increase in prevalence of macular degeneration & diabetic retinopathy, and favorable regulatory scenario for introduction of innovative technologies are boosting the growth of the Global Ocular Drug Delivery Technology market. Rising demand for targeted drug delivery to the affected ocular tissue, and elimination of drug due to nasolacrimal drainage system when administered via topical route are some of the factors expected to drive the growth of Global Ocular Drug Delivery Technology market during the forecast ...
http://bizpr.us/2017/07/28/ocular-drug-delivery-technology-market-global-industry-analysis-size-share-growth-trends-forecast-2017-2025/
Delivery from Episcleral Exoplants | IOVS | ARVO JournalsDelivery from Episcleral Exoplants | IOVS | ARVO Journals
purpose. To assess the impact of an episcleral exoplant on transscleral delivery.. methods. New Zealand White rabbits were given a periocular injection of sodium fluorescein (fluorescein, 376 Da) or an episcleral exoplant loaded with fluorescein. Two types of exoplants were tested: (1) a rigid polyethylene device, impermeable on one side and open to the sclera on the other, that contained compressed pellets of fluorescein and was sutured loosely (apposition group) or tightly to indent the sclera (indentation group) and (2) flexible refillable silicone exoplants also open to the sclera that were secured by suturing, to form a sealed episcleral chamber that was filled with a fluorescein solution. Ocular and plasma fluorophotometry were performed at several time points, and histology was performed to evaluate the effect of exoplants on the periocular tissue.. results. Within 20 minutes of a periocular injection of fluorescein, peak fluorescence was visible in the anterior chamber (AC) and at later ...
http://iovs.arvojournals.org/article.aspx?articleid=2124534
Innovative Contact Lens Delivery Glaucoma Medication Continously for a Month - Healthcanal.com : Healthcanal.comInnovative Contact Lens Delivery Glaucoma Medication Continously for a Month - Healthcanal.com : Healthcanal.com
BOSTON - For nearly half a century, contact lenses have been proposed as a means of ocular drug delivery that may someday replace eye drops, but achieving controlled drug release has been a significant challenge. Researchers at Massachusetts Eye and Ear/Harvard Medical School Department of Ophthalmology, Boston Childrens Hospital, and the Massachusetts Institute of Technology are one step closer to an eye drop-free reality with the development of a drug-eluting contact lens designed for prolonged delivery of latanoprost, a common drug used for the treatment of glaucoma, the leading cause of irreversible blindness worldwide. In general, eye drops are an inefficient method of drug delivery that has notoriously poor patient adherence. This contact lens design can potentially be used as a treatment for glaucoma and as a platform for other ocular drug delivery applications, said Joseph Ciolino, M.D, Mass. Eye and Ear cornea specialist and lead author of the paper. The contacts were designed with ...
https://www.healthcanal.com/eyes-vision/45687-innovative-contact-lens-delivery-glaucoma-medication-continously-for-a-month.html
Most recent papers with the keyword Breakthrough, research | Read by QxMDMost recent papers with the keyword Breakthrough, research | Read by QxMD
Development of newer drug carrier systems by the researchers has resulted in numerous breakthroughs in the development and manufacturing of ocular products. The ocular bioavailability of drugs at the posterior segment of the eye is a challenging task in the present scenario. Naturally derived macromolecular carriers are widely used to increase the efficacy of ocular drugs. They provide enhanced corneal permeability and retention effect at the surface of cornea for a prolonged period of time. In this regimen the present review focuses towards the major ocular diseases and their prevalence and development of efficient drug carrier systems utilizing various naturally derived macromolecules for improved delivery of drugs to treat ocular diseases ...
https://www.readbyqxmd.com/keyword/23931
Formulation and evaluation of Moxifloxacin hydrochloride ocular nanoparticlesFormulation and evaluation of Moxifloxacin hydrochloride ocular nanoparticles
The objective of the present study was to prepare controlled release formulation of Moxifloxacin hydrochloride ocular nanoparticles. The nanoparticles were prepared by solvent displacement method using Eudragit RL 100 as a polymer. Different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. The formulations were evaluated in terms of particle size, FTIR, drug entrapment efficiency and in vitro drug release profile was examined. The anti bacterial activity against gram positive and gram negative bacteria were determined. In vivo studies were carried out by Draize test. The mean particle size for drug loaded formulations was found to be below 200 nm. The zeta potential remained in the range of positive values for all batches +10 mV to +40mV. The formulation possesses good antibiotic activity against Escherichia coli, Bacillus subtilus and Staphylococcus aureus microorganism and no eye irritation on in-vivo testing.
http://www.ijnd.ir/article_3648.html
Potential of the bioflavonoids in the prevention/treatment of ocular disorders - Majumdar - 2010 - Journal of Pharmacy and...Potential of the bioflavonoids in the prevention/treatment of ocular disorders - Majumdar - 2010 - Journal of Pharmacy and...
Objectives Flavonoids are a common group of plant polyphenols that give colour and flavour to fruits and vegetables. In recent years, flavonoids have gained importance in the pharmaceutical field through their beneficial effects on human health and are widely available as nutritional supplements. Several pharmacological actions of the bioflavonoids may be useful in the prevention or treatment of ocular diseases responsible for vision loss such as diabetic retinopathy, macular degeneration and cataract. This review aims to summarize the potential therapeutic applications of various bioflavonoids in different ocular diseases and also discusses delivery of these agents to the ocular tissues.. Key findings It is apparent that the flavonoids are capable of acting on various mechanisms or aetiological factors responsible for the development of different sight threatening ocular diseases. From a drug delivery perspective, ocular bioavailability depends on the physicochemical and biopharmaceutical ...
http://onlinelibrary.wiley.com/doi/10.1211/jpp.62.08.0001/abstract
Naphazoline and breastfeeding. Are they compatible?Naphazoline and breastfeeding. Are they compatible?
A sympathomimetic with alpha-adrenergic activity. It has a vasoconstrictor effect that reduces mucosal swelling and congestion. Topical nasal use (single dose) or ophthalmological (2-4 times a day). Since the last update we have not found published data in relation to breastfeeding. The small dose and the low plasma absorption of most topical nasal or ophthalmological preparations make transfer into breastmilk in significant amounts unlikely. Do not exceed the recommended dose and time periods in order to avoid undesirable side effects and the possible decrease in milk cited by some authors (Nice 2000) for other similar drugs, although not proven in practice. It is a product which has very little literature and almost none related to pharmacokinetics. As a nasal decongestant, it is discouraged by some authors (Nice 2000), with better known drugs from the same group being preferred (Anderson 2000). Ophthalmic administration is fully compatible with breastfeeding. Absorption can be
http://e-lactancia.org/breastfeeding/naphazoline/product/
Non-Chemotherapy-Related Drug-Induced Lung Injury - The Cardiology AdvisorNon-Chemotherapy-Related Drug-Induced Lung Injury - The Cardiology Advisor
As a drug-related phenomenon, bronchospasm may present in an isolated fashion or as a component of anaphylaxis. Many drugs are associated with bronchospasm (Figure 2), but the prototypic medications of concern are beta-blockers, aspirin, and NSAIDs. Drug-induced bronchospasm is of particular concern in patients with asthma or pre-existing airways disease.. The use of beta-blockers in patients with asthma or COPD remains controversial. As beta-agonists are used to treat bronchospasm, it logically follows that beta-blockade may cause bronchospasm. When nonselective beta-blockers were introduced, numerous cases were reported of severe or fatal asthma exacerbations after oral, IV, or even ophthalmic administration.. These cases resulted in recommendations to avoid beta-blockade in patients with asthma or COPD. However, there is abundant evidence that beta-blockers have significant clinical benefit in coronary disease, hypertension, and heart failure; a general avoidance of this therapy in those with ...
https://www.thecardiologyadvisor.com/home/decision-support-in-medicine/pulmonary-medicine/non-chemotherapy-related-drug-induced-lung-injury/
Protasis Customer Questionnaire US Letter Template | keboto.orgProtasis Customer Questionnaire US Letter Template | keboto.org
Protasis Customer Questionnaire US Letter Template is a fully editable template that can be customized to your needs. It is designed in a way that facilitates the user without the need for specialized knowledge of software and processing. Most of its elements are combined in such a way that the drag n drop technique can be applied. It has a minimum storage space as it has been compressed properly. As a result Protasis Customer Questionnaire US Letter Template will help you design your own corporate questionnaire is handy, functional and stylish. Save time and impress with your professional image! Τhe Protasis Customer Questionnaire US Letter Template has been used with free fonts that you can download freely and install them on your system. The photos are indicative and are not included in the product due to copyright.
https://keboto.org/shop/protasis-customer-questionnaire-us-letter-template
Merikon Customer Questionnaire US Letter Template | keboto.orgMerikon Customer Questionnaire US Letter Template | keboto.org
Merikon Customer Questionnaire US Letter Template is a fully editable template that can be customized to your needs. It is designed in a way that facilitates the user without the need for specialized knowledge of software and processing. Most of its elements are combined in such a way that the drag n drop technique can be applied. It has a minimum storage space as it has been compressed properly. As a result Merikon Customer Questionnaire US Letter Template will help you design your own corporate questionnaire is handy, functional and stylish. Save time and impress with your professional image! Τhe Merikon Customer Questionnaire US Letter Template has been used with free fonts that you can download freely and install them on your system. The photos are indicative and are not included in the product due to copyright. [su_label type=success]Buy this template and earn 50% discount with your next purchase![/su_label]
https://keboto.org/shop/merikon-customer-questionnaire-us-letter-template
IJMS | Free Full-Text | Orientational Packing of a Confined Discotic Mesogen in the Columnar Phase | NotesIJMS | Free Full-Text | Orientational Packing of a Confined Discotic Mesogen in the Columnar Phase | Notes
The stacking of discotic molecules (hexakis(alkoxy)diquinoxalino[2,3-a:2,3-c]phenazines) in the columnar phase sandwiched between two flat glass substrates has been studied. The surface free energy of the substrates, measured by means of sessile drop technique, is found to have significant influence on the way that the discotic molecules anchor on the surface, and a steady thermal state of the system is crucial for a homogenous orientation of the discotic columns. On a surface of high free energy, the discotic molecules anchor with their disc-face toward the surface. A decrease in the surface free energy of the substrate causes the discotic columns to tilt away from the normal of the substrate.
http://www.mdpi.com/1422-0067/11/3/943/notes
An Evaluation of Use of Topical Ocular Hypotensive Medication by Compliance - Full Text View - ClinicalTrials.govAn Evaluation of Use of Topical Ocular Hypotensive Medication by Compliance - Full Text View - ClinicalTrials.gov
This is an open-label study in patients who are currently using either a topical prostaglandin as sole ocular hypotensive medical therapy q.d., or a topical prostaglandin plus an adjunctive topical ocular hypotensive marketed product either q.d., or b.i.d. in the same eye(s). Compliance will be measured over the two months of participation ...
https://clinicaltrials.gov/ct2/show/NCT00329095
OHR Pharmaceutical Inc (OHRP.OQ) Quote | ReutersOHR Pharmaceutical Inc (OHRP.OQ) Quote | Reuters
Ohr Pharmaceutical, Inc. is a pharmaceutical company focused on the development of therapeutics and delivery technologies for the treatment of ocular disease. The Companys development pipeline consists of several programs and indications at various stages of development. Its product pipeline includes Squalamine Lactate Ophthalmic Solution 0.2% (Squalamine, also known as OHR-102), SKS Sustained Release Ocular Drug Delivery Platform Technology, Animal Model for Dry- Age-Related Macular Degeneration (AMD) and Non-Ophthalmology Assets. OHR-102 is a therapeutic product that provides a non-invasive therapy to improve vision outcomes. The SKS sustained release technology is designed to develop drug formulations for ocular disease. In the Companys animal model for dry-AMD, mice are immunized with a carboxyethylpyrrole, which is bound to mouse serum albumin. It also owns various other compounds in earlier stages of development, including the PTP1b inhibitor Trodusquemine and related analogs.
https://uk.mobile.reuters.com/business/stocks/overview/OHRP.OQ
Simbrinza (Brimonidine And Brinzolamide Ophthalmic) - Side Effects, Interactions, Uses, Dosage, Warnings | Everyday HealthSimbrinza (Brimonidine And Brinzolamide Ophthalmic) - Side Effects, Interactions, Uses, Dosage, Warnings | Everyday Health
Find everything you need to know about Simbrinza (Brimonidine And Brinzolamide Ophthalmic), including what it is used for, warnings, reviews, side effects, and interactions. Learn more about Simbrinza (Brimonidine And Brinzolamide Ophthalmic) at EverydayHealth.com.
https://www.everydayhealth.com/drugs/simbrinza
Moderate inhibition of myocardial matrix metalloproteinase-2 by ilomastat is cardioprotectiveModerate inhibition of myocardial matrix metalloproteinase-2 by ilomastat is cardioprotective
Pharmacological inhibition of matrix metalloproteinase-2 (MMP-2) is a promising target for acute cardioprotection against ischemia/reperfusion injury. Therefore, here we investigated if the MMP inhibitor ilomastat administered either before ischemia or before reperfusion is able to reduce infarct si …
https://pubmed.ncbi.nlm.nih.gov/24380772/
Comparison of the Uptake and Retention of Carcinogen by Breast and Fat (after Feeding) and Skin (after Topical Administration)....Comparison of the Uptake and Retention of Carcinogen by Breast and Fat (after Feeding) and Skin (after Topical Administration)....
Semantic Scholar extracted view of Comparison of the Uptake and Retention of Carcinogen by Breast and Fat (after Feeding) and Skin (after Topical Administration). by Fred G. Bock
https://www.semanticscholar.org/paper/Comparison-of-the-Uptake-and-Retention-of-Carcinog-Bock/5aa9391d4a4f03945c461759ac376d9ec35cdc41
photokeratitis - Illuminating Engineering Societyphotokeratitis - Illuminating Engineering Society
We use cookies to give you the best experience on our website. By continuing to browse the site, you are agreeing to our use of cookies ...
https://www.ies.org/definitions/photokeratitis/
Betaxolol Hydrochloride Loaded Chitosan Nanoparticles for Ocular Delivery and their Anti-glaucoma Efficacy | Bentham ScienceBetaxolol Hydrochloride Loaded Chitosan Nanoparticles for Ocular Delivery and their Anti-glaucoma Efficacy | Bentham Science
Title:Betaxolol Hydrochloride Loaded Chitosan Nanoparticles for Ocular Delivery and their Anti-glaucoma Efficacy. VOLUME: 10 ISSUE: 5. Author(s):Kunal Jain, R. Suresh Kumar, Sumeet Sood and G. Dhyanandhan. Affiliation:Department of Pharmaceutics, J.S.S College of Pharmacy, Udhagamandalam, India.. Keywords:Betaxolol, glaucoma, chitosan, nanoparticles, ocular delivery.. Abstract:Many effective anti-glaucoma drugs available for the treatment of ocular hypertension and open angle glaucoma are associated with rapid and extensive precorneal loss caused by the drainage and high tear fluid turnover. The present study involved design of mucoadhesive nanoparticulate carrier system containing betaxolol hydrochloride for ocular delivery to improve its corneal permeability and precorneal residence time. Nanoparticles were prepared by spontaneous emulsification method and had a particle size of 168-260nm with zeta potential of 25.2-26.4 mV. The in vitro release studies in simulated tear fluid exhibited ...
http://www.eurekaselect.com/115014/article?tracking-code=4
Ophthalmic Drugs Market Key Players, Competitive Strategies, Regional Analysis Forecast 2028 - PharmiWeb.comOphthalmic Drugs Market Key Players, Competitive Strategies, Regional Analysis Forecast 2028 - PharmiWeb.com
An ophthalmic drugs are medication used to treat eye infections. Ophthalmic drug forms have been one of the most important and widely developed areas of pharmaceutical technology over the few years.The global ophthalmic drugs market is expected to register significant growth in the forecoming years. Major factors dr...
https://www.pharmiweb.com/press-release/2019-02-19/ophthalmic-drugs-market-key-players-competitive-strategies-regional-analysis-forecast-2028
Ophthalmic Drugs Market to Witness an Outstanding Growth by 2025 - TMR Research BlogOphthalmic Drugs Market to Witness an Outstanding Growth by 2025 - TMR Research Blog
Some of the key players operating in the global Ophthalmic Drugs Market are ALLERGAN, Aerie Pharmaceuticals, Inc., Pfizer Inc., Valeant Pharmaceuticals International, Inc., Bayer AG, Genentech, Inc., Novartis AG , Regeneron Pharmaceuticals, Inc., Shire, and Santen Pharmaceutical Co., Ltd. Novartis, of them, is a leading player, which held a share of 12% in the market in 2012.. Noticeable trends in the global ophthalmic drugs market are keen players entering into co-development agreements to formulate novel biological agents having lesser treatment durations, emerging market players focusing on unmet medical needs in ophthalmology, and generic manufacturers bolstering their distribution networks of affordable drugs in rural areas of developing regions, having maximum visually challenged people.. As per a report by Transparency Market Research, the global ophthalmic drugs market will likely attain a value of US$34.3 bn by 2025 from US$24.4 bn in 2016 by registering a tepid CAGR of 4.0% from 2017 ...
https://tmrresearchblog.com/ophthalmic-drugs-market-witness-outstanding-growth-2025/
51st week of 2010 patent applcation highlights part 4951st week of 2010 patent applcation highlights part 49
Non-aqueous oil delivery system for ophthalmic drugs - The present invention relates to a delivery system for ophthalmic drugs, and more particularly, to a non aqueous oil delivery system. Low concentrations of ophthalmic drugs suspended in an oil vehicle delivery system are as therapeutically effective in man and animals as the corresponding higher concentrations of ophthalmic drugs that are commercially used in aqueous solutions. Eye drops that utilize this nonaqueous oil delivery system, when used in man, are comfortable to use and produce little ocular irritation, have a longer shelf-life, low systemic toxic potential, and only short term blurring of vision. Using this nonaqueous oil delivery system, a single drop of ophthalmic drug with a concentration that is 10 times less than the same drug used in commercially available aqueous eye drops is as effective as the commercially available aqueous ophthalmic eye drops that require many applications to be effective. In addition, utilizing the ...
http://www.patentsencyclopedia.com/hgl/12-23-10/12-23-10_49
Methyl tert-butyl ether (MTBE) CASRN 1634-04-4 | DTXSID3020833 | IRIS | US EPA, ORDMethyl tert-butyl ether (MTBE) CASRN 1634-04-4 | DTXSID3020833 | IRIS | US EPA, ORD
Increased absolute and relative liver and kidney weights and increased severity of spontaneous renal lesions (females), increased prostration (females), and swollen periocular tissue (males and females ...
https://cfpub.epa.gov/ncea/iris2/chemicalLanding.cfm?substance_nmbr=0545
Ophthalmic Drugs Market Size, Share | Industry Growth Report, 2027Ophthalmic Drugs Market Size, Share | Industry Growth Report, 2027
The global ophthalmic drugs market size was valued at USD 31.0 billion in 2019 and is expected to expand at a CAGR of 5.0% from 2019 to 2027. Rising prevalence of eye diseases and disorders along with presence of robust pipeline of molecules are some of the key factors driving the growth
https://www.grandviewresearch.com/industry-analysis/ophthalmic-therapeutics-drug-market
Global Ophthalmic Drugs Sales Market Report 2017 - QY ResearchGlobal Ophthalmic Drugs Sales Market Report 2017 - QY Research
Research Report on Global Ophthalmic Drugs Sales Market Report 2017. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
https://www.qyresearchreports.com/report/global-ophthalmic-drugs-sales-market-report-2017.htm
Asia-Pacific Ophthalmic Drugs Market Report 2017 - QY ResearchAsia-Pacific Ophthalmic Drugs Market Report 2017 - QY Research
Research Report on Asia-Pacific Ophthalmic Drugs Market Report 2017. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
https://www.qyresearchreports.com/report/asia-pacific-ophthalmic-drugs-market-report-2017.htm
Global Ophthalmic Drugs Market: Players Entering into Co-development Agreements to Enhance Product Portfolio, finds TMRGlobal Ophthalmic Drugs Market: Players Entering into Co-development Agreements to Enhance Product Portfolio, finds TMR
Ophthalmic Drugs Market will likely attain a value of US$34.3 bn by 2025 from US$24.4 bn in 2016 by registering a tepid CAGR of 4.0% from 2017 to 2025.
https://www.transparencymarketresearch.com/pressrelease/ophthalmic-drugs-market.htm
Module 5/Pharmacology and Disease/Section 9/Pharmacology/Ophthalmic Drugs Flashcards - Cram.comModule 5/Pharmacology and Disease/Section 9/Pharmacology/Ophthalmic Drugs Flashcards - Cram.com
Study Flashcards On Module 5/Pharmacology and Disease/Section 9/Pharmacology/Ophthalmic Drugs at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
http://www.cram.com/flashcards/module-5pharmacology-and-diseasesection-9pharmacologyophthalmic-drugs-226319
BlablaDoctor - Group Profile - Photokeratitis, Ultraviolet keratitisBlablaDoctor - Group Profile - Photokeratitis, Ultraviolet keratitis
This is the business view business. Photokeratitis or ultraviolet keratitis is a painful eye condition, caused by exposure of insufficiently protected eyes to the ultraviolet (UV) rays from either natural or artificial sources. Photokeratitis is akin to a sunburn of the cornea and conjuncti...
http://blabladoctor.com/group/photokeratitis-ultraviolet-keratitis
Bubble point pressures of binary methanol/water mixtures in fine-mesh screens - Hartwig - 2013 - AIChE Journal - Wiley Online...Bubble point pressures of binary methanol/water mixtures in fine-mesh screens - Hartwig - 2013 - AIChE Journal - Wiley Online...
Binary methanol/water mixture bubble point tests involving three samples of fine-mesh, stainless steel screens as porous liquid acquisition devices are presented in this article. Contact angles are measured as a function of methanol mass fraction using the Sessile Drop technique. Pretest predictions are based on a Langmuir isotherm fit. Predictions and data match for methanol mole fractions greater than 50% when pore diameters are based on pure liquid tests. For all three screens, bubble point is shown to be a maximum at a methanol mole fraction of 50%. Model and data are in disagreement for mole fractions less than 50%, which is attributed to variations between surface and bulk fluid properties. A critical Zisman surface tension value of 23.2 mN/m is estimated, below which contact angles can be assumed to be zero. Solid/vapor and solid/liquid interfacial tensions are also estimated using the equation of state analysis from Neumann and Good. Published 2013 American Institute of Chemical ...
http://onlinelibrary.wiley.com/doi/10.1002/aic.14293/abstract?globalMessage=0&systemMessage=Wiley+Online+Library+is+migrating+to+a+new+platform+powered+by+Atypon%2C+the+leading+provider+of+scholarly+publishing+platforms.+The+new+Wiley+Online+Library+will+be+migrated+over+the+weekend+of+February+24+and+25+and+will+be+live+on+February+26%2C+2018.+For+more+information%2C+please+visit+our+migration+page%3Ahttp%3A%2F%2Fwww.wileyactual.com%2FWOLMigration%2F
brinzolamide ophthalmic | PeaceHealthbrinzolamide ophthalmic | PeaceHealth
Brinzolamide reduces the amount of fluid in the eye, which decreases pressure inside the eye. Brinzolamide ophthalmic (for the eyes) is used to treat certain types of glaucoma and other causes of high pressure inside the eye. Brinzolamide ophthalmic may also be used for other purposes not listed in this medication guide.
https://www.peacehealth.org/medical-topics/content/multum/d04301a1.html
ACUSTREAM™: BRINGING TOPICAL OPHTHALMIC DRUG DELIVERY INTO THE MODERN ERA - ONdrugDeliveryACUSTREAM™: BRINGING TOPICAL OPHTHALMIC DRUG DELIVERY INTO THE MODERN ERA - ONdrugDelivery
This is especially important for a chronic condition such as glaucoma, for example. When it comes to treating glaucoma, healthcare providers have a broad array of increasingly invasive treatments for managing intraocular pressure (IOP), starting with simple topical drug formulations before moving up to stents and possibly even surgery. Therefore, if a patient has compliance and adherence issues with their initial topical treatments, it increases the probability that IOP will not be well-managed and that more drops would have to be prescribed to try to manage IOP before moving on to increasingly invasive, surgical treatments.. AcuStreams clear benefits position it for success in the topical ophthalmic market, in the treatment of conditions such as glaucoma, dry eye, uveitis, allergic disease and infections. Additionally, the regulatory pathway to approval for AcuStream combined with approved drugs can follow streamlined processes such as the US FDAs 505(b)(2) approval pathway. Because of its ...
https://www.ondrugdelivery.com/acustream-bringing-topical-ophthalmic-drug-delivery-into-the-modern-era/
Compliance Archives - Cogent QC: Award-Winning Loan Quality Control & Compliance SoftwareCompliance Archives - Cogent QC: Award-Winning Loan Quality Control & Compliance Software
In a growing trend towards streamlining and standardization of quality control and compliance methodologies, HUD has introduced a Defect Taxonomy in its FHAs Single Family Housing Loan Quality Assessment Methodology. This document lays out the methodology that the FHA plans to adopt to improve its own QA efforts.. Knowing how FHA will be evaluating loans is helpful in designing your own QA program. Particularly useful is the definition of nine defect categories, numerous sources/causes for the defects, and four levels of defect severity. These can be roughly translated in Cogentspeak to audit question categories, preset comments, and findings levels respectively.. For those configuring their Cogent FHA audit shells: your work has just become easier and more complex at the same time.. ...
https://cogentqc.com/category/compliance/
Ophthalmic Drug DeliveryOphthalmic Drug Delivery
Meet top and best Ophthalmologist, Optometrists, Eye surgeons and Medical professionals from Europe, USA, middle-east, Asia pacific, at Ophthalmology conferences, Eye care Conferences scheduled during October 28-29, 2020 in Amsterdam, Netherlands
https://ophthalmologists.ophthalmologyconferences.com/events-list/ophthalmic-drug-delivery
Ophthalmic irrigation, extraocular ophthalmic Drug Interactions - Drugs.comOphthalmic irrigation, extraocular ophthalmic Drug Interactions - Drugs.com
View drug interactions with ophthalmic irrigation, extraocular ophthalmic. This medication may also interact with certain foods or diseases.
https://www.drugs.com/drug-interactions/ophthalmic-irrigation-extraocular-ophthalmic.html
UDS Library System catalog › Results of search for ccl=Provider:Butterworth,
OConnor Daviess ophthalmic drugs : diagnostic and therapeutic uses. by Davies, P. H. OConnor (Patrick Henry OConnor), 1922 , Hopkins, G. A , Pearson, R. M. (Richard M.) , Davies, P. H. OConnor (Patrick Henry OConnor), 1922-. Actions and uses of ophthalmic drugs.. Edition: 4th ed. / revised by Graham Hopkins, Richard Pearson.Material type: ...
http://libcatalogue.uds.edu.gh/cgi-bin/koha/opac-search.pl?q=ccl=Provider%3AButterworth%2C&offset=160&sort_by=relevance_dsc
Corneal Transplants | Alan Carlson MDCorneal Transplants | Alan Carlson MD
I want to credit the insight given to me from Dr. Doug Rett, OD, FAAO:. In 1958 Muro Pharmacal Labs was founded and it manufactured ophthalmic drugs. It was named Muro for the Italian word for wall, which I think is fitting given the barrier that the cornea plays in penetration of ocular drugs. With tight junctions, pH sensitivity and the hydrophobic nature of the epithelium and hydrophilic nature of the stroma, its difficult for modern-day drug companies to pass medication through the cornea, let alone in the 1950s. In 1968 Muro was sold to George Behrakis, a pharmacist from Lowell, […]. ...
http://www.alancarlsonmd.com/category/corneal-transplantation
Self-Assembling Nanocomplexes: Transmogrifying Ocular Biologics Delivery | AAPS Blog
By Abhirup Mandal and Ashim K. Mitra Ocular delivery of biologics has been challenging. It has been a constant source of exasperation for ophthalmologists and formulation experts over the last few decades. High-molecular weight, short half-lives, structural complexity, and poor permeability render biologics as the most challenging molecules to formulate and deliver across ocular barriers. Since…
https://aapsblog.aaps.org/2017/03/21/self-assembling-nanocomplexes-transmogrifying-ocular-biologics-delivery/
EpiCorneal - MatTek CorporationEpiCorneal - MatTek Corporation
The EpiCorneal 3D human tissue model provides a highly predictive non-animal alternative to assess ophthalmic drug delivery, wound healing and tissue regeneration, disease modeling (e.g. dry eye) and corneal infection.. Details ...
https://www.mattek.com/product-category/tissue-models/epicorneal/
SearchSearch
AIMS: Corneal perfusion chambers are important tools in the development and assessment of ophthalmic drugs. The aim of this study was to design and test a modified perfusion chamber suitable for topical application of drugs ...
https://dspace.flinders.edu.au/xmlui/handle/2328/987/discover?filtertype_0=author&filter_0=Coster%2C+Douglas+John&filter_relational_operator_0=equals&filtertype=subject&filter_relational_operator=equals&filter=Australian+Standard+Research+Classification+321016+Ophthalmology+and+Vision+Science
Free Medical Flashcards about Pharm chapter 18Free Medical Flashcards about Pharm chapter 18
Free flashcards to help memorize facts about Ophthalmic Drugs Chapter 18. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests.
https://www.studystack.com/flashcard-1229731
Ophthalmic drug administrationOphthalmic drug administration
... is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical ... Ophthalmic drug administration, Medical terminology, Routes of administration). ... This drainage is thought to be the reason that systemic side effects exist from such administration. The U.S. Centers for ... ISBN 978-81-8061-099-8. Li CC, Chauhan A (May 2006). "Modeling Ophthalmic Drug Delivery by Soaked Contact Lenses". Industrial ...
https://en.wikipedia.org/wiki/Ophthalmic_drug_administration
SuprofenSuprofen
U.S. Food and Drug Administration. Archived from the original on 1 January 2009. "Suprofen ophthalmic". Drugs.com. v t e ( ... It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic ...
https://en.wikipedia.org/wiki/Suprofen
NepafenacNepafenac
"Drug Approval Package: Nepafenac Ophthalmic Suspension, 0.3% NDA #203491". U.S. Food and Drug Administration (FDA). April 8, ... "Drug Approval Package: Nevanac (Nepafenac) Ophthalmic Suspension NDA #021862". U.S. Food and Drug Administration (FDA). January ... Gaynes BI, Onyekwuluje A (June 2008). "Topical ophthalmic NSAIDs: a discussion with focus on nepafenac ophthalmic suspension". ... On February 25, 2005, Alcon filed a New Drug Application (NDA) with the U.S. Food and Drug Administration (FDA) for Nevanac 0.1 ...
https://en.wikipedia.org/wiki/Nepafenac
Intravitreal administrationIntravitreal administration
... do not meaningfully lower the risk of post-injection infection and periodic multi-day administration of topical ophthalmic ... Intravitreal is a route of administration of a drug, or other substance, in which the substance is delivered into the vitreous ... in 2020 which may lead to a person identifying the wrong eye for self-administration include length of time since last ... Dave, Sarita B.; Toma, Hassanain S.; Kim, Stephen J. (October 2011). "Ophthalmic Antibiotic Use and Multidrug-Resistant ...
https://en.wikipedia.org/wiki/Intravitreal_administration
Sub-Tenon injectionSub-Tenon injection
Ophthalmic drug administration). ... It involves administration of a medication to the area between ... Sub-Tenon injection is an ocular route of drug administration. ...
https://en.wikipedia.org/wiki/Sub-Tenon_injection
NetarsudilNetarsudil
"Rhopressa (netarsudil) Ophthalmic Solution". U.S. Food and Drug Administration (FDA). 29 January 2018. Retrieved 3 June 2020. " ... In the United States, in December 2017, the Food and Drug Administration (FDA) approved a 0.02% ophthalmic solution for the ... Dasso L, Al-Khaled T, Sonty S, Aref AA (2018). "Profile of netarsudil ophthalmic solution and its potential in the treatment of ... New Drug Therapy Approvals 2017 (PDF). U.S. Food and Drug Administration (FDA) (Report). January 2018. Retrieved 16 September ...
https://en.wikipedia.org/wiki/Netarsudil
Color vision testColor vision test
The variance in test administration is minimized The tests are immune to mistakes in interpreting the results Test parameters ... Birch, Jennifer (June 2008). "Pass rates for the Farnsworth D15 colour vision test". Ophthalmic and Physiological Optics. 28 (3 ... Color Vision". Federal Aviation Administration. Retrieved 10 September 2022. Cole, Barry L; Maddocks, Jennifer D (1998-11-01 ...
https://en.wikipedia.org/wiki/Color_vision_test
NorfloxacinNorfloxacin
The concomitant administration of a non-steroidal anti-inflammatory drug (NSAID) with a quinolone, including norfloxacin, may ... Merck Sharp & Dohme (September 2000). "Chibroxin (Norfloxacin) Ophthalmic solution" (PDF). USA: FDA. Arabyat RM, Raisch DW, ... "www.fda.gov". Food and Drug Administration. Skalsky K, Yahav D, Lador A, Eliakim-Raz N, Leibovici L, Paul M (April 2013). " ... Administration of magnesium, aluminum, or calcium containing antacids can reduce the absorption of norfloxacin. Norfloxacin is ...
https://en.wikipedia.org/wiki/Norfloxacin
AlcaftadineAlcaftadine
"Lastacaft (alcaftadine ophthalmic solution 0.25%)" (PDF). Drug Use Review. U.S. Food and Drug Administration. 21 June 2012. ... "Drug Approval Package: Lastacaft (alcaftadine) Ophthalmic Solution NDA #022134". U.S. Food and Drug Administration (FDA). 24 ... The most common seen side effect of alcaftadine administration was irritation or a stinging sensation at the administration ... It was approved by the U.S. Food and Drug Administration (FDA) in July 2010, under the trade name Lastacaft. Alcaftadine is an ...
https://en.wikipedia.org/wiki/Alcaftadine
LevofloxacinLevofloxacin
Food and Drug Administration (Press release). 10 July 2018. Retrieved 15 April 2019. "Levofloxacin ophthalmic medical facts ... Following oral administration, 87% of an administered dose was recovered in the urine as unchanged drug within 2 days. Less ... Peak levels in skin are achieved 3 hours after administration and exceed those in plasma by a factor of 2. Similarly, lung ... It was first approved for marketing in Japan in 1993, for oral administration, and Daiichi marketed it there under the brand ...
https://en.wikipedia.org/wiki/Levofloxacin
OmidenepagOmidenepag
"Drug Approval Package: Omlonti". U.S. Food and Drug Administration (FDA). 20 October 2022. Retrieved 4 December 2022. Duggan S ... "Santen and UBE Received FDA Approval for Omlonti (Omidenepag Isopropyl Ophthalmic Solution) 0.002% for the Reduction of ... December 2018). "Omidenepag Isopropyl Ophthalmic Solution 0.002%: First Global Approval". Drugs. 78 (18): 1925-1929. doi: ...
https://en.wikipedia.org/wiki/Omidenepag
Palpebral fissurePalpebral fissure
United States Food and Drug Administration (Nov. 2006). Xalatan (latanoprost ophthalmic solution) 0.005% (50 μg/mL). Accessed 5 ... In animal studies using four times the therapeutic concentration of the ophthalmic solution latanoprost, the size of the ...
https://en.wikipedia.org/wiki/Palpebral_fissure
Peter HershPeter Hersh
Ophthalmic Practice 1995; 13:126-133. Burnstein Y, Hersh PS. Photorefractive keratectomy following radial keratotomy. J Refract ... "ViewPoint™ CK System - P010018". Food and Drug Administration. Hersh, Peter (2005). "Optics of Conductive Keratoplasty: ... "Summary minutes of the ophthalmic devices panel meeting" (PDF). www.fda.gov. Retrieved November 30, 2001. " ... Food and Drug Administration (FDA) of the excimer laser for the correction of nearsightedness in the United States. Hersh was ...
https://en.wikipedia.org/wiki/Peter_Hersh
1970 New Year Honours1970 New Year Honours
John Ophthalmic Hospital, Jerusalem. Joan Honor, Assistant Administrator, War on Want. William John Hood, District Inspector, ... Fred Horton, JP, Personnel and Administration Officer, Prestwick Airport, British Airports Authority. Joseph Arthur Horton, ... Ernest Michael Miller, Chief Administration Officer, The Football Association. Mary Edwina Millican, Honorary Secretary, ... Barbara Eileen Sanders, Senior Personal Secretary, Office of the Parliamentary Commissioner for Administration. Gwendolen ...
https://en.wikipedia.org/wiki/1970_New_Year_Honours
CanthaxanthinCanthaxanthin
The Food and Drug Administration (FDA) has no "tanning pills" approved for sale in the United States. In spite of this, there ... Ophthalmic Research. 46 (2): 103-106. doi:10.1159/000323813. PMID 21346389. S2CID 7495247. "Warning Letters Cite Cosmetics as ... "Sun Safety: Protect the Skin You're In!". FDA & You, Issue #3. Food and Drug Administration. Spring-Summer 2003. Archived from ... "Code of Federal Regulations Title 21, 1 April 2012". Food and Drug Administration. Retrieved 2013-06-21. "Feeds Regulations, ...
https://en.wikipedia.org/wiki/Canthaxanthin
1974 Birthday Honours1974 Birthday Honours
First Secretary (Administration), H M. Embassy, Berlin. Robert Alan Minchell, Director of Surveys, Government of Malawi. James ... Alison Gordon Kiddie, Ward Sister, Ophthalmic Ward, Dundee Royal Infirmary. Freeman Atkinson Kiddle, Central Planning Engineer ... For services to the administration of justice in Belize. Arthur Thomas Draper, Managing Director, Produce Marketing Board, The ... George Bernard Doggett, lately Administration Officer, British Trade Commission, Hong Kong. Major Gerald Foster Doggett, MC, ...
https://en.wikipedia.org/wiki/1974_Birthday_Honours
1971 Birthday Honours1971 Birthday Honours
Richard Leslie Bellis, Ophthalmic Optician, Department of Health and Social Security. Thomas Benson, Chief Engineer, Menswear ... John Granville Galilee, Honorary Secretary, Institute of Shops Acts Administration. Edith Eileen Gallagher. For services to the ... Harold Sydney Peters, MBE, lately Permanent Secretary (Administration), Office of the President and Cabinet, Malawi. Edgar ... Dennis George Plaister, MBE, Senior Principal, Office of the Parliamentary Commissioner for Administration. Samuel Walter Potts ...
https://en.wikipedia.org/wiki/1971_Birthday_Honours
Dermatologic and Ophthalmic Drugs Advisory CommitteeDermatologic and Ophthalmic Drugs Advisory Committee
Food and Drug Administration (FDA). The committee, consisting of members from academic and clinical dermatology, ophthalmology ... The Dermatologic And Ophthalmic Drugs Advisory Committee (DODAC) receives requests for technical and clinical evaluation of new ... Food and Drug Administration, National agencies for drug regulation, Regulators of biotechnology products, Pharmacy ... the CDER and CBER divisions of the FDA about the advisability of approving new medications to treat dermatologic and ophthalmic ...
https://en.wikipedia.org/wiki/Dermatologic_and_Ophthalmic_Drugs_Advisory_Committee
Artificial tearsArtificial tears
U.S. Food and Drug Administration. 39 (3): 8-9. PMID 16127813. Archived from the original on January 20, 2009. Retrieved 14 May ... Soparkar, Charles N. S. (1997-01-01). "Acute and Chronic Conjunctivitis Due to Over-the-counter Ophthalmic Decongestants". ... Hessen, Michelle; Akpek, Esen Karamursel (April 2014). "Dry Eye: an Inflammatory Ocular Disease". Journal of Ophthalmic & ...
https://en.wikipedia.org/wiki/Artificial_tears
Fluorescein (medical use)Fluorescein (medical use)
Duvall, Brian; Kershner, Robert M. (2006). Ophthalmic Medications and Pharmacology. Journal of Ophthalmic Nursing & Technology ... Food and Drug Administration (FDA). 9 April 2018. Retrieved 11 March 2020. "Altafluor- fluorescein sodium and benoxinate ... "Drug Approval Package: Altafluor Benox (fluorescein sodium and benoxinate hydrochloride ophthalmic solution)". U.S. ...
https://en.wikipedia.org/wiki/Fluorescein_(medical_use)
List of soft contact lens materialsList of soft contact lens materials
FDA Division of Ophthalmic and Ear, Nose and Throat Devices. p. 97. Archived from the original (Microsoft PowerPoint) on 18 ... The US Food and Drug Administration (FDA) defines soft contact lenses as: made of soft, flexible plastics that allow oxygen to ... Ophthalmic Devices Panel of the Medical Devices Advisory Committee (May 13, 2014). "FDA Executive Summary Prepared for the May ... U.S. Food and Drug Administration. n.d. p. 25. Archived from the original (PDF) on 1 May 2015. Retrieved 18 June 2016. " ...
https://en.wikipedia.org/wiki/List_of_soft_contact_lens_materials
2002 New Year Honours2002 New Year Honours
Director of Academic Administration, University of Kent and of UK Socrates-Erasmus Office. For services to Higher Education and ... Formerly consultant Ophthalmic Surgeon, Princess Alexandra Eye Pavilion, Royal Infirmary of Edinburgh. For services to Medicine ... Head of Policy, Administration and Finance Section, Invest UK, Department of Trade and Industry. (London, W6) Douglas Alexander ... For services to the Administration of Justice and to the community in Hampshire. (Alton, Hampshire) John Vincent Palmer. ...
https://en.wikipedia.org/wiki/2002_New_Year_Honours
GatifloxacinGatifloxacin
An editorial by Jerry Gurwitz in the same issue called for the Food and Drug Administration (FDA) to consider giving Tequin a ... By contrast, ophthalmic gatifloxacin is generally well tolerated. The observed systemic concentration of the drug following ... Therefore, the systemic exposures resulting from the gatifloxacin ophthalmic solution are not likely to pose any risk for ... Gatifloxacin is currently available in the US and Canada only as an ophthalmic solution.[citation needed] In 2011, the Union ...
https://en.wikipedia.org/wiki/Gatifloxacin
FH AachenFH Aachen
Physics/Business Administration, German, English, and Chemistry (only for FeP Students) was based on the framework regulations ... Ophthalmic Optics and Optometry (tuition required) • Physical Engineering • Rail Vehicle Engineering Universität Duisburg-Essen ... Bernd Pietschmann Administration Campus Bayernallee Campus Eupener Straße Campus Goethestraße Campus Hohenstaufenallee "Über ... Business Administration with Informatics SRH Hochschule in Nordrhein-Westfalen (tuition required): • Business Management • ...
https://en.wikipedia.org/wiki/FH_Aachen
Mercury regulation in the United StatesMercury regulation in the United States
Federal Food, Drug, and Cosmetic Act (FFDCA) The Food and Drug Administration is responsible for mercury in food, drugs, and ... Yellow mercuric oxide is not recognized as a safe and effective ophthalmic anti-infective ingredient. The FDA also regulates ... and Food and Drug Administration (FDA), as well as a variety of state and local authorities. EPA published the Mercury and Air ...
https://en.wikipedia.org/wiki/Mercury_regulation_in_the_United_States
UnoprostoneUnoprostone
It was approved by the Food and Drug Administration in 2000. In 2009, Sucampo Pharmaceuticals acquired the rights to the drug ... "An evidence-based review of unoprostone isopropyl ophthalmic solution 0.15% for glaucoma: place in therapy". Clinical ... "Drug Approval Package". Food and Drug Administration. "Sucampo Pharmaceuticals, Inc. Acquires Rights to Rescula for U.S. and ...
https://en.wikipedia.org/wiki/Unoprostone
OphthalmicOphthalmic
Ophthalmology Ophthalmic nerve Ophthalmic artery Ophthalmic veins Ophthalmic drug administration, as with eye drops Ophthalmia ... Look up ophthalmic in Wiktionary, the free dictionary. Ophthalmic means pertaining to the eye, and can refer to: ... This disambiguation page lists articles associated with the title Ophthalmic. If an internal link led you here, you may wish to ...
https://en.wikipedia.org/wiki/Ophthalmic
Intracameral injectionIntracameral injection
v t e (Eye diseases, Medical emergencies, Ophthalmic drug administration, All stub articles, Medical treatment stubs). ... The Food and Drug Administration (FDA) has not approved antibiotics for this use and it is considered 'off-label'. Concerns ...
https://en.wikipedia.org/wiki/Intracameral_injection
LevobupivacaineLevobupivacaine
Most ADRs relate to administration technique (resulting in systemic exposure) or pharmacological effects of anesthesia, however ... Levobupivacaine is indicated for local anaesthesia including infiltration, nerve block, ophthalmic, epidural and intrathecal ...
https://en.wikipedia.org/wiki/Levobupivacaine
CarbacholCarbachol
It is primarily used for various ophthalmic purposes, such as for treating glaucoma, or for use during ophthalmic surgery. It ... Topical ocular administration is used to decrease intraocular pressure in people with primary open-angle glaucoma. Intraocular ... Carbachol is primarily used in the treatment of glaucoma, but it is also used during ophthalmic surgery. Carbachol eyedrops are ... In topical ocular and intraocular administration its principal effects are miosis and increased aqueous humour outflow. In the ...
https://en.wikipedia.org/wiki/Carbachol
List of Statutory Instruments of the United Kingdom, 1994List of Statutory Instruments of the United Kingdom, 1994
Administration and Enforcement) (Amendment) Regulations 1994 S.I. 1994/504 Council Tax (Administration and Enforcement) ( ... Testing of Sight by Persons Training as Ophthalmic Opticians Rules) Order of Council 1994 (S.I. 1994/70) Criminal Justice Act ... Wills and Administration Proceedings (Northern Ireland) Order 1994 (S.I. 1994/1899) Contracts (Applicable Law) Act 1990 ( ... Integrated Administration and Control System (Amendment) Regulations 1994 (S.I. 1994/1134) Transfrontier Shipment of Waste ...
https://en.wikipedia.org/wiki/List_of_Statutory_Instruments_of_the_United_Kingdom,_1994
1960 Birthday Honours1960 Birthday Honours
Leslie Harding Barnes, Administration Officer, British Military Government, Berlin. May Lelia Anne Berry, lately Shorthand- ... Benjamin William Rycroft, OBE, MD, FRCS, Consulting Ophthalmic Surgeon. Samuel Isidore Salmon. For political and public ... Ernest Bellevue, OBE, Head of Finance Department, Crown Agents for Oversea Governments and Administrations. Raymond Marie ... Reginald Kelly, an Attorney in Mafeking; Legal Adviser to the Bechuanaland Protectorate Administration. Richard William Kelly, ...
https://en.wikipedia.org/wiki/1960_Birthday_Honours
Tom CoburnTom Coburn
During the administration of President George W. Bush, Coburn spoke out against the threat by some Democrats to filibuster ... From 1970 to 1978, Coburn served as a manufacturing manager at the Ophthalmic Division of Coburn Optical Industries in Colonial ... Coburn was involved in the Bush Administration's struggle with Congress over whistleblower rights. In the case of Garcetti v. ... In 2000, he sponsored a bill to prevent the Food and Drug Administration from developing, testing, or approving the ...
https://en.wikipedia.org/wiki/Tom_Coburn
GlaucomaGlaucoma
Wiping the eye with an absorbent pad after the administration of eye drops may result in fewer adverse effects, like the growth ... It also showed that there were lack of professional ophthalmic services in the area of high deprivation. A study in 2017 shows ...
https://en.wikipedia.org/wiki/Glaucoma
MacropsiaMacropsia
Ophthalmic Physiol Opt. 1995; 15:339-343. Kroyer K, Jensen OM, Larsen M. Objective signs of photoreceptor displacement by ... the disorganization and agitation followed the first administration of zolpidem, and once zolpidem was discontinued, there were ... hypoglycaemia is defined as having an abnormally low blood-sugar level due to anything other than the exogenous administration ... case of macropsia thought to be induced by citalopram involves a woman who experienced macropsia after her first administration ...
https://en.wikipedia.org/wiki/Macropsia
Optical ConfederationOptical Confederation
It agrees on advice to opticians with the Department of Health about the administration of NHS sight tests and what fees ... of Contact Lens Manufacturers Association of Optometrists Federation of Manufacturing Opticians Federation of Ophthalmic and ...
https://en.wikipedia.org/wiki/Optical_Confederation
John Browning (scientific instrument maker)John Browning (scientific instrument maker)
He was well known among London's ophthalmic surgeons for his various ophthalmic instruments. Browning had a large part in ... "England & Wales, National Probate Calendar (Index of Wills and Administrations), 1861-1941". Calendar of the Grants of Probate ... "England & Wales, National Probate Calendar (Index of Wills and Administrations), 1861-1941". Calendar of the Grants of Probate ... and Letters of Administration made in the Probate Registries of the High Court of Justice in England. Principal Probate ...
https://en.wikipedia.org/wiki/John_Browning_(scientific_instrument_maker)
CalcineurinCalcineurin
The microemulsion formulation is approved by the U.S. Food and Drug Administration for treatment of severely active RA. It is ... administered as ophthalmic emulsion). Calcineurin is linked to receptors for several brain chemicals including glutamate, ...
https://en.wikipedia.org/wiki/Calcineurin
History of medicineHistory of medicine
Abd al-Malik ibn Marwan, the fifth caliph of the Umayyad, developed governmental administration, adopted Arabic as the main ... Other Alexandrian surgeons gave us ligature (hemostasis), lithotomy, hernia operations, ophthalmic surgery, plastic surgery, ... Japanese colonial medicine and Gotō Shinpei's combination of medical police and local self-administration". Medical History. 55 ...
https://en.wikipedia.org/wiki/History_of_medicine
UveitisUveitis
Prior to the administration of corticosteroids, corneal ulcers must be ruled out. This is typically done using a fluorescence ... Uveitis is an ophthalmic emergency that requires urgent control of the inflammation to prevent vision loss. Treatment typically ... Symptoms include eye pain, eye redness, floaters and blurred vision, and ophthalmic examination may show dilated ciliary blood ... Dick AD (1 January 2012). "Road to fulfilment: taming the immune response to restore vision". Ophthalmic Research. 48 (1): 43-9 ...
https://en.wikipedia.org/wiki/Uveitis
IsotretinoinIsotretinoin
The US Food and Drug Administration (FDA) requires the companies marketing the drug to put this website in place as a risk ... Kremer I, Gaton DD, David M, Gaton E, Shapiro A (1994). "Toxic effects of systemic retinoids on meibomian glands". Ophthalmic ... Three metabolites of isotretinoin are detectable in human plasma after oral administration: 4-oxo-isotretinoin, retinoid acid ( ... "FDA information, side effects, and uses / Accutane (isotretinoin)". U. S. Food and Drug Administration (FDA). Retrieved 20 ...
https://en.wikipedia.org/wiki/Isotretinoin
Róża CzackaRóża Czacka
In 1946, the Society for the Care of the Blind received state permission for the administration and use of a 70 ha agricultural ... She visited the patients of ophthalmic clinics, contacted doctors who could treat them and organized fundraising at Holy Cross ...
https://en.wikipedia.org/wiki/Róża_Czacka
2020 New Year Honours2020 New Year Honours
For services in the field of Sport and in particular cricket administration. Arthur Henry Ricardo Blackman. For services to ... Sandra Ann Taylor, Lead Ophthalmic Research Nurse, Royal Liverpool and Broadgreen University Hospitals NHS Trust. For services ... For services to Public Administration. Maureen Payne, President of Age Concern Costa Blanca Sur, Alicante, Spain. For services ... For services to public administration. Juliet Rose Pleydell Bouverie, Chief Executive, The Stroke Association. For services to ...
https://en.wikipedia.org/wiki/2020_New_Year_Honours
List of Statutory Rules of Northern Ireland, 2009List of Statutory Rules of Northern Ireland, 2009
151) The General Ophthalmic Services (Amendment No. 2) Regulations (Northern Ireland) 2009 (S.R. 2009 No. 152) The Optical ... 62 (C. 3)) The Bank Administration Rules (Northern Ireland) 2009 (S.R. 2009 No. 63) The Bank Insolvency Rules (Northern Ireland ... 14) General Ophthalmic Services (Amendment) Regulations (Northern Ireland) 2009 (S.R. 2009 No. 16) The Planning (Control of ... 32) Local Government Pension Scheme (Administration) Regulations (Northern Ireland) 2009 (S.R. 2009 No. 33) Local Government ...
https://en.wikipedia.org/wiki/List_of_Statutory_Rules_of_Northern_Ireland,_2009
COACOA
... used within the Federal Aviation Administration Coahuila, (ISO 3166 code MX-COA), a state in Mexico Coat of Arms, a unique ... see Drug reference standard Certified Ophthalmic Assistant, entry level assistant as certified by Joint Commission on Allied ...
https://en.wikipedia.org/wiki/COA
Corneal cross-linkingCorneal cross-linking
Based on three 12-month clinical trials, the US Food and Drug Administration approved riboflavin ophthalmic solution and ... for topical ophthalmic use PHOTREXA (riboflavin 5'-phosphate ophthalmic solution) 0.146% for topical ophthalmic use For use ... In 2016, the US Food and Drug Administration approved riboflavin ophthalmic solution crosslinking based on three 12-month ... "PHOTREXA VISCOUS- riboflavin 5-phosphate in 20% dextran ophthalmic solution/ drops PHOTREXA- riboflavin 5-phosphate ophthalmic ...
https://en.wikipedia.org/wiki/Corneal_cross-linking
Topical prednisoloneTopical prednisolone
Co-administration of prednisolone eye drops with ophthalmic nonsteroidal anti-inflammatory agents (NSAIDs) may perhaps ... "PrednisoLONE Acetate Ophthalmic Suspension". www.vetrxdirect.com. Retrieved 2022-03-16. "Prednisolone Acetate Ophthalmic for ... "Prednisolone (Ophthalmic Route) Side Effects - Mayo Clinic". www.mayoclinic.org. Retrieved 2022-03-16. "Common and Rare Side ... "Prednisolone ophthalmic Use During Pregnancy". Drugs.com. Retrieved 2022-03-16. Arslan, Necmi; Tepe, Davut; Taştan, Eren; ...
https://en.wikipedia.org/wiki/Topical_prednisolone
World Association of Eye HospitalsWorld Association of Eye Hospitals
... funding and quality to promote and to maintain contacts with ophthalmic organizations worldwide to promote and to maintain ... it promotes ophthalmology practice through social outreach and by providing information on eye care and health administration. ...
https://en.wikipedia.org/wiki/World_Association_of_Eye_Hospitals
Side effects of cyproterone acetateSide effects of cyproterone acetate
Kuhl H (2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration" (PDF). Climacteric ... J Ophthalmic Vis Res. 13 (3): 355-358. doi:10.4103/jovr.jovr_21_17. PMC 6058554. PMID 30090195. Boer, Mirra; Moernaut, Loes; ... "Prolactin-producing pituitary adenoma in a male-to-female transsexual patient with protracted estrogen administration. A ... "Toxic hepatitis after sequential administration of flutamide and cyproterone acetate". Dig. Dis. Sci. 49 (3): 462-5. doi: ...
https://en.wikipedia.org/wiki/Side_effects_of_cyproterone_acetate
St John Ambulance AustraliaSt John Ambulance Australia
St John Ambulance in Australia raises funds and recruits staff for the St John Ophthalmic Eye Hospital in Jerusalem. Funds are ... and analgesic administration, remote first aid and occupational first aid. ... "Ophthalmic". St John Ambulance Australia. Retrieved 28 April 2009. "Community Care". St John Ambulance Australia. Retrieved 28 ...
https://en.wikipedia.org/wiki/St_John_Ambulance_Australia
IEC Institute of Health Sciences & ResearchIEC Institute of Health Sciences & Research
Health Administration, etc.) MS (Anatomy, ENT, General Surgery, Obstetrics & Gynaecology, etc.) Diploma in Bacteriology, ... Optometry of Ophthalmic Technology, Operation Theater Technology, Medical Biotechnology) Bachelor of Ayurveda Medicine & ...
https://en.wikipedia.org/wiki/IEC_Institute_of_Health_Sciences_&_Research
University of Tennessee Health Science CenterUniversity of Tennessee Health Science Center
... and transfer skills and knowledge to the next generation of ophthalmic physicians and researchers. The Health Science Center is ... and dual PharmD/Master of Business Administration. The Hamilton Eye Institute, located in Memphis, is the department of ...
https://en.wikipedia.org/wiki/University_of_Tennessee_Health_Science_Center
List of Statutory Instruments of the United Kingdom, 1989List of Statutory Instruments of the United Kingdom, 1989
5) Order 1989 (S.I. 1989/1174) National Health Service (General Ophthalmic Services) Amendment (No. 2) Regulations 1989 (S.I. ... 6) Order 1989 (S.I. 1989/50) National Health Service Functions (Directions to Authorities and Administration Arrangements) ... Administration of Justice Act 1985 (Commencement No. 6) Order 1989 (S.I. 1989/287) Legal Aid Act 1988 (Commencement No.3) Order ... General Ophthalmic Services) Amendment Regulations 1989 (S.I. 1989/395) National Health Service (Optical Charges and Payments) ...
https://en.wikipedia.org/wiki/List_of_Statutory_Instruments_of_the_United_Kingdom,_1989
Vitreomacular adhesionVitreomacular adhesion
Ophthalmic Surg Lasers Imaging. 2007;38(4):270-275. Liu DT, Chan CK, Fan DS, Lam SW, Lam DS, Chan WM. Choroidal folds after 25 ... Microplasmin intravitreal administration in patients with vitreomacular traction scheduled for vitrectomy: the MIVI I trial. ... European Ophthalmic Review, 2011,5(1):69-73 Koerner F, Garweg J. [Diseases of the vitreo-macular interface]. Klin Monbl ... Microplasmin intravitreal administration in patients with vitreomacular traction scheduled for vitrectomy: the MIVI I trial. ...
https://en.wikipedia.org/wiki/Vitreomacular_adhesion
List of Statutory Rules of Northern Ireland, 2002List of Statutory Rules of Northern Ireland, 2002
407) Social Security Administration (Northern Ireland) Act 1992 (Amendment) Order (Northern Ireland) 2002 (S.R. 2002 No. 408) ... 84) Optical Charges and Payments and General Ophthalmic Services (Amendment) Regulations (Northern Ireland) 2002 (S.R. 2002 No ... 378) Statutory Paternity Pay and Statutory Adoption Pay (Administration) Regulations (Northern Ireland) 2002 (S.R. 2002 No. 379 ...
https://en.wikipedia.org/wiki/List_of_Statutory_Rules_of_Northern_Ireland,_2002
LifitegrastLifitegrast
... lifitegrast ophthalmic solution) 5% for topical ophthalmic use" (PDF). Novartis. June 2020. Retrieved 2021-02-05. Tauber J, ... which submitted a new drug application to the US Food and Drug Administration (FDA) in March 2015. The FDA granted Shire a ... December 2015). "Lifitegrast Ophthalmic Solution 5.0% versus Placebo for Treatment of Dry Eye Disease: Results of the ...
https://en.wikipedia.org/wiki/Lifitegrast
Bachelors degreeBachelor's degree
Ministry of Education (22 January 2019). "普通高等学校本科专业目录－国务院国有资产监督管理委员会". State-owned Assets Supervision and Administration ... The National Institute of Ophthalmic Sciences is among the post-secondary institutions that offer such programs. It is the ... Bachelor of Business Administration (BBA), Bachelor of Information Management (BIM), Bachelor of Business Information Systems ( ... The rest of the programs typically lead to a Bachelor of Engineering degree (BEng
https://en.wikipedia.org/wiki/Bachelor's_degree
Müller gliaMüller glia
Further studies performed in mice have shown that overexpression of Ascl1 in Müller glia in conjunction with administration of ... Ophthalmic Research. 29 (5): 326-40. doi:10.1159/000268031. PMID 9323724. NIF Search - Muller Cell via the Neuroscience ...
https://en.wikipedia.org/wiki/Müller_glia
Elestat (Epinastine HCl Ophthalmic Solution): Uses, Dosage, Side Effects, Interactions, WarningElestat (Epinastine HCl Ophthalmic Solution): Uses, Dosage, Side Effects, Interactions, Warning
Epinastine HCl Ophthalmic Solution) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, ... Lenses may be reinserted after 10 minutes following administration of ELESTAT® .. Topical Ophthalmic Use Only. For topical ... Topical Ophthalmic Use Only. ELESTAT® is for topical ophthalmic use only and not for injection or oral use. ... ELESTAT® (epinastine HCl ophthalmic solution) 0.05% is supplied sterile in opaque white LDPE plastic bottles with dropper tips ...
https://www.rxlist.com/elestat-drug.htm
DailyMed - TRAVOPROST OPHTHALMIC- travoprost ophthalmic solution solutionDailyMed - TRAVOPROST OPHTHALMIC- travoprost ophthalmic solution solution
It is not known if travoprost is present in human milk following ophthalmic administration. A study in lactating rats ... TRAVOPROST OPHTHALMIC- travoprost ophthalmic solution solution. Number of versions: 3. Published Date (What is this?). Version ... TRAVOPROST OPHTHALMIC- travoprost ophthalmic solution solution. To receive this label RSS feed. Copy the URL below and paste it ... TRAVOPROST OPHTHALMIC- travoprost ophthalmic solution solution. If this SPL contains inactivated NDCs listed by the FDA ...
https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=39c8f172-9dc6-4adf-8e7f-4d1cb6940926
Atropine Sulfate Ophthalmic Ointment: Package Insert / Prescribing Information - Drugs.comAtropine Sulfate Ophthalmic Ointment: Package Insert / Prescribing Information - Drugs.com
Atropine Sulfate Ophthalmic Ointment package insert / prescribing information for healthcare professionals. Includes: ... Atropine Sulfate Ophthalmic Ointment Dosage and Administration. Apply a small amount of ointment to the conjunctival sac once ... FOR OPHTHALMIC USE ONLY. How is Atropine Sulfate Ophthalmic Ointment Supplied. Atropine Sulfate Ophthalmic Ointment, 1% is ... Humira, dexamethasone ophthalmic, triamcinolone ophthalmic, epinephrine, azathioprine, phenylephrine ophthalmic, atropine ...
https://www.drugs.com/pro/atropine-sulfate-ophthalmic-ointment.html
Corneal Decompensation After Intraocular Ophthalmic Surgery -- Missouri, 1998Corneal Decompensation After Intraocular Ophthalmic Surgery -- Missouri, 1998
Food and Drug Administration. FDA safety alert: warning regarding the use of the Abtox Plazlyte sterilization system. Rockville ... Instruments routinely used in ophthalmic surgery often have small hinges and small lumens. In addition, ophthalmic cannulas ( ... Louis VAMC, and ophthalmic instruments were sterilized by steam autoclave. No additional cases have occurred. Abtox is ... Food and Drug Administration. A nationwide warning against the use of Abtox Plazlyte Sterilization System. Rockville, ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/00052237.htm
Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry...Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry...
The novel ophthalmic formulations CsA 0.05% and 0.1% were safe and effective in the treatment of moderate to severe dry eye ... Ophthalmic Solutions / administration & dosage * Ophthalmic Solutions / adverse effects * Ophthalmic Solutions / therapeutic ... Objective: To compare the efficacy and safety of cyclosporin A ([CsA] 0.05% and 0.1% ophthalmic emulsions) to vehicle in ... Conclusions: The novel ophthalmic formulations CsA 0.05% and 0.1% were safe and effective in the treatment of moderate to ...
https://pubmed.ncbi.nlm.nih.gov/10768324/?dopt=Abstract
Xiidra (lifitegrast ophthalmic) dosing, indications, interactions, adverse effects, and moreXiidra (lifitegrast ophthalmic) dosing, indications, interactions, adverse effects, and more
... lifitegrast ophthalmic), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation ... Administration. Ophthalmic Administration. Drops are in single-use containers; discard the single-use container immediately ... Systemic absorption is low following ophthalmic administration. 19% of patients studied had plasma lifitegrast trough ... encoded search term (lifitegrast ophthalmic (Xiidra)) and lifitegrast ophthalmic (Xiidra) What to Read Next on Medscape ...
https://reference.medscape.com/drug/xiidra-lifitegrast-ophthalmic-1000032
Administration | Xiidra® (lifitegrast ophthalmic solution) 5% | ECPAdministration | Xiidra® (lifitegrast ophthalmic solution) 5% | ECP
... lifitegrast ophthalmic solution) 5%. See full safety and Prescribing Info. ... Access additional information about the administration of Xiidra® ( ... Xiidra® administration One drop of Xiidra is used. in each eye, twice daily. (approximately 12 hours apart)1. ... Xiidra® administration One drop of Xiidra is used in each eye, twice daily. (approximately 12 hours apart).1 ...
https://www.xiidra-ecp.com/using-xiidra/administration/
Uveitic Glaucoma Medication: Beta-blockers, Carbonic anhydrase inhibitors, Adrenergic agonists, Prostaglandin analogs,...Uveitic Glaucoma Medication: Beta-blockers, Carbonic anhydrase inhibitors, Adrenergic agonists, Prostaglandin analogs,...
Nonsteroidal anti-inflammatory prodrug for ophthalmic use. Following administration, converted by ocular tissue hydrolases to ... Nonsteroidal Anti-Inflammatory Drug (NSAID), Ophthalmic. Nepafenac ophthalmic suspension (Nevanac). *View full drug information ... Ophthalmic corticosteroid indicated for inflammation and pain associated with ocular surgery. Available as a 0.05% ophthalmic ... J Ophthalmic Inflamm Infect. 2018 Jun 18. 8 (1):9. [QxMD MEDLINE Link]. ...
https://www.medscape.com/answers/1206838-200870/which-medications-in-the-drug-class-topical-corticosteroids-are-used-in-the-treatment-of-uveitic-glaucoma
Cholinesterase Inhibitors: Part 4 - Section 11 Management Strategy 3: Medications Atropine | Environmental Medicine | ATSDRCholinesterase Inhibitors: Part 4 - Section 11 Management Strategy 3: Medications Atropine | Environmental Medicine | ATSDR
Preferred routes of administration of atropine. Type of cholinesterase inhibitor toxicity that may require extremely high doses ... Atropine: Route of Administration. In approximate order of preference, the following routes of administration can be used for ... Ophthalmic: Anticholinergic eye drops (e.g., atropine or homatropine) have been recommended for severe eye pain caused by ... Ophthalmic. Topical mydriatics, such as atropine, and homatropine, can provide relief from eye pain and reflex nausea and ...
https://www.atsdr.cdc.gov/csem/cholinesterase-inhibitors/atropine.html
Stokes Healthcare Inc. Issues Voluntary Nationwide Recall of Pilocarpine 0.1% Ophthalmic Solution Due to a High Level of...Stokes Healthcare Inc. Issues Voluntary Nationwide Recall of Pilocarpine 0.1% Ophthalmic Solution Due to a High Level of...
The ophthalmic solution has been found to contain a higher level of the preservative benzalkonium chloride than is typical ... is voluntarily recalling 1 lot of 81 units of Pilocarpine 0.1% Ophthalmic Solution, to the consumer and veterinarian office ... This recall is being conducted with the knowledge of the U.S. Food and Drug Administration. ... The affected Pilocarpine 0.1% Ophthalmic Solution lots include the following lot number and expiration date:. Product. Lot ...
https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/stokes-healthcare-inc-issues-voluntary-nationwide-recall-pilocarpine-01-ophthalmic-solution-due-high
Monkeypox Virus and Ophthalmology-A Primer on the 2022 Monkeypox Outbreak and Monkeypox-Related Ophthalmic Disease | Cornea |...Monkeypox Virus and Ophthalmology-A Primer on the 2022 Monkeypox Outbreak and Monkeypox-Related Ophthalmic Disease | Cornea |...
This Special Communication reviews clinical information for the ophthalmologist regarding the ophthalmic manifestations of ... Conflict of Interest Disclosures: Dr Chodosh reported receiving consultant fees from the US Food and Drug Administration ... Monkeypox Virus and Ophthalmology-A Primer on the 2022 Monkeypox Outbreak and Monkeypox-Related Ophthalmic Disease. To identify ... Monkeypox ophthalmic manifestations may present to the ophthalmologist, or the ophthalmologist may be involved in comanagement ...
https://edhub.ama-assn.org/jn-learning/module/2797919?resultClick=1&bypassSolrId=J_2797919
Lifitegrast Ophthalmic Solution 5% (Xiidra) for Dry Eye Disease | AAFPLifitegrast Ophthalmic Solution 5% (Xiidra) for Dry Eye Disease | AAFP
Lenses should not be reinserted until at least 15 minutes after administration of the drops.1 Each single-use ampule should be ... Lifitegrast ophthalmic solution 5% (Xiidra). One drop in each eye every 12 hours. Single-use ampule of 5% solution. $527. ... Lifitegrast ophthalmic solution 5% (Xiidra) is labeled for the treatment of dry eye disease, also known as keratoconjunctivitis ... 2 Lifitegrast is not systemically detectable despite long-term administration, making systemic effects unlikely.1,2 The ...
https://www.aafp.org/pubs/afp/issues/2018/0715/p119.html
Viroptic (trifluridine ophthalmic solution) | CenterWatchViroptic (trifluridine ophthalmic solution) | CenterWatch
Continuous administration of Viroptic for periods exceeding 21 days should be avoided because of potential ocular toxicity. ... Viroptic Ophthalmic Solution, 1% Sterile (trifluridine ophthalmic solution) is an antiviral drug. ... Instill one drop of Viroptic Ophthalmic Solution, 1% onto the cornea of the affected eye every 2 hours while awake for a ... The clinical efficacy of Viroptic in the treatment of stromal keratitis and uveitis due to herpes simplex virus or ophthalmic ...
https://www.centerwatch.com/directories/1067-fda-approved-drugs/listing/4410-viroptic-trifluridine-ophthalmic-solution
National Outbreak of Acanthamoeba Keratitis Associated with Use of a Contact Lens Solution, United States - Volume 15, Number 8...
US Food and Drug Administration. Ophthalmic devices panel advisory meeting, transcripts. 2008 Jun 10 [cited 2008 July 30]. ... These results were communicated to the Food and Drug Administration (FDA) and were rapidly disseminated (8). On May 26, 2007, ... testing (18). However, after this outbreak, the Ophthalmic Devices Panel of the FDA Medical Devices Advisory Committee has ... Available from http://www.fda.gov/ohrms/dockets/ac/cdrh08.html#Ophthalmic ...
https://wwwnc.cdc.gov/eid/article/15/8/09-0225
Sustained Release Excipients Market Size Report, 2022-2030Sustained Release Excipients Market Size Report, 2022-2030
Route of Administration Insights. The oral drug delivery segment dominated the industry in 2021 and accounted for the maximum ... Oral drug delivery is a widely used route of drug administration, which has been studied for systematic delivery via several ... This route of delivery minimizes various limitations associated with the oral and parenteral route of administration. The ... Sustained Release Excipients Market Size, Share & Trends Analysis Report By Route Of Administration (Oral, Transdermal), By ...
https://www.grandviewresearch.com/industry-analysis/sustained-release-excipients-market
Cequa: Uses, Side Effects, Dosages, PrecautionsCequa: Uses, Side Effects, Dosages, Precautions
Other Ophthalmic Cyclosporines In addition to Cequa, the ophthalmic cyclosporine Restasis may also be prescribed in cases of ... Restasis was the first cyclosporine drop to be approved by the Food and Drug Administration (FDA). Unlike Cequa, Restasis is an ... This ophthalmic solution with cyclosporine has a strength of 0.9 milligrams per milliliter (mL). The manufacturer recommends ... Practical guidance for the use of cyclosporine ophthalmic solutions in the management of dry eye disease. Clin Ophthalmol. 2019 ...
https://www.verywellhealth.com/cequa-cyclosporine-ophthalmic-solution-5181673
Evaluating New Ophthalmic Digital Devices for Safety and Effectiveness in the Context of Rapid Technological Development<...
N2 - Importance: The US Food and Drug Administrations medical device regulatory pathway was initially conceived with hardware ... Evaluating New Ophthalmic Digital Devices for Safety and Effectiveness in the Context of Rapid Technological Development. JAMA ... Evaluating New Ophthalmic Digital Devices for Safety and Effectiveness in the Context of Rapid Technological Development. In: ... Evaluating New Ophthalmic Digital Devices for Safety and Effectiveness in the Context of Rapid Technological Development. / ...
https://jhu.pure.elsevier.com/en/publications/evaluating-new-ophthalmic-digital-devices-for-safety-and-effectiv
Pharmaceuticals || Appasamy Associates | Appasamy Associates - Trusted name in Ophthalmic Instruments and PharmaceuticalsPharmaceuticals || Appasamy Associates | Appasamy Associates - Trusted name in Ophthalmic Instruments and Pharmaceuticals
DOSAGE & ADMINISTRATION:. *For ocular conditions: One or two drops instilled into the conjunctival sac every 4 to 6 hours. ...
https://www.appasamy.com/pharmaceuticals.php?category=Antibiotics_with_Steroids&product=Aflox-D
Ophthalmic Medical Assistant Diploma | Gateway Technical CollegeOphthalmic Medical Assistant Diploma | Gateway Technical College
Work in optometry and vision clinics with Gateways Ophthalmic Medical Assistant technical diploma offered through a shared ... Students apply basic pharmacodynamics to identifying common medications, medication preparation, and administration of ... Ophthalmic Medical Assistant. If you see yourself helping people care for their eyes, the Ophthalmic Medical Assistant ... Start the Ophthalmic Medical Assistant program at Gateway to earn up to 8 credits toward the degree at LTC under the shared ...
https://www.gtc.edu/programs/technical-diplomas/ophthalmic-medical-assistant
ICU Medicals ChemoClave™ System Included in Mobius Therapeutics Mitosol® Kit for Use in Glaucoma SurgeryICU Medical's ChemoClave™ System Included in Mobius Therapeutics' Mitosol® Kit for Use in Glaucoma Surgery
About Mobius Therapeutics, LLC: Mobius Therapeutics is an early stage venture focused on ophthalmic surgery solutions. Its ... the refractive and corneal indications are awaiting approval by the Food and Drug Administration. ... an FDA-cleared drug used in ophthalmic surgery containing the active ingredient Mitomycin-C, which is cytotoxic and listed on ...
https://www.prnewswire.com/news-releases/icu-medicals-chemoclave-system-included-in-mobius-therapeutics-mitosol-kit-for-use-in-glaucoma-surgery-157918775.html
2020-2021 BCSC Basic and Clinical Science Course™2020-2021 BCSC Basic and Clinical Science Course™
Chapter 14: Selected Systemic Conditions With Neuro-Ophthalmic Signs. Neuro-Ophthalmic Manifestations of Infectious Diseases. ... Gadolinium administration reveals enhancement.. Excerpted from BCSC 2020-2021 series: Section 5 - Neuro-Ophthalmology. For more ... Neuro-ophthalmic findings include homonymous hemianopia and quadrantanopia, ocular motor CN palsies, and gaze palsies. Long- ...
https://www.aao.org/bcscsnippetdetail.aspx?id=96b41b3d-852c-46a4-9190-5b41f02e27af
Prednisolone Ophthalmic: MedlinePlus Drug InformationPrednisolone Ophthalmic: MedlinePlus Drug Information
Prednisolone Ophthalmic: learn about side effects, dosage, special precautions, and more on MedlinePlus ... If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administrations (FDA) ... Ophthalmic prednisolone comes as a solution (liquid) and a suspension (eye drops) to instill in the eye and as an eye ointment ... Ophthalmic prednisolone reduces the irritation, redness, burning, and swelling of eye inflammation caused by chemicals, heat, ...
https://medlineplus.gov/druginfo/meds/a682794.html
0 Physician / Surgeon - Administration Jobs in Ithaca, New York | Health eCareers0 Physician / Surgeon - Administration Jobs in Ithaca, New York | Health eCareers
Administration in Ithaca, New York. Health eCareers is one of the best recruitment portals with career opportunities for ...
https://www.healthecareers.com/physician-surgeon-jobs/administration/2981/jobs-in-united-states/new-york/ithaca/
Buy Cyclogyl Eye Drops - Competitive Price | Canada PharmacyBuy Cyclogyl Eye Drops - Competitive Price | Canada Pharmacy
Routes of administration. Ophthalmic. About Dr. Alex Covey (Page Author) Alex Covey studies chemistry and microbiology as an ...
https://www.canadapharmacy.com/products/cyclogyl
DOTmed News Search: Barbara KramDOTmed News Search: Barbara Kram
FDA Announces Class I Recall of Ophthalmic Surgical Device. by Barbara Kram 01/05/2009 The U.S. Food and Drug Administration ... HIMSS Releases Healthcare IT Blueprint for Obama Administration and Congress. by Barbara Kram 12/22/2008 Health IT presents ... UD30654 of Healon D, an ophthalmic viscosurgical device (OVD) manufactured by Advanced Medical Optics Inc. (AMO) of Santa Ana, ... CNNs top doc would join President-elect Obamas administration, several outlets have confirmed. ...
https://www.dotmed.com/news/search.html?key=Barbara%20Kram&search_author=1§ion=&sort=&offset=600
Pediapred (prednisolone sodium phosphate) dose, indications, adverse effects, interactions... from PDR.netPediapred (prednisolone sodium phosphate) dose, indications, adverse effects, interactions... from PDR.net
Ophthalmic Administration. Apply topically to the eye. For ophthalmic use only.. For ophthalmic suspensions, shake well prior ... Ophthalmic Route. Following ophthalmic administration, prednisolone is absorbed through the aqueous humor, with only minimal ... It is not known whether topical ophthalmic administration of corticosteroids could result in sufficient systemic absorption to ... It is not known whether topical ophthalmic administration of corticosteroids could result in sufficient systemic absorption to ...
https://pdr.net/drug-summary/Pediapred-prednisolone-sodium-phosphate-2751
2020-2021 BCSC Basic and Clinical Science Course™2020-2021 BCSC Basic and Clinical Science Course™
... glucocorticoid administration is generally unnecessary prior to ophthalmic surgery. Occasionally, general anesthesia with a ... Ophthalmic surgery is usually performed with the patient under local sedation, is of short duration relative to thoracic and ... Medical optimization may involve increasing the patients inhaler regimen, administration of antibiotics (if infection is ... It is important for the ophthalmic surgeon to ensure that the patients respiratory status is optimized preoperatively. If a ...
https://www.aao.org/bcscsnippetdetail.aspx?id=d76b17ac-7ff0-4630-a3f8-ce23afb398c8
Astellas and Seagen Announce Positive Topline Results For PADCEV® (enfortumab vedotin-ejfv) with KEYTRUDA® (pembrolizumab) as...Astellas and Seagen Announce Positive Topline Results For PADCEV® (enfortumab vedotin-ejfv) with KEYTRUDA® (pembrolizumab) as...
Consider treatment with ophthalmic topical steroids, if indicated after an ophthalmic exam. Consider dose interruption or dose ... Infusion site extravasation Skin and soft tissue reactions secondary to extravasation have been observed after administration ... In February 2020, the U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy designation for enfortumab vedotin ... Ensure adequate venous access prior to starting PADCEV and monitor for possible extravasation during administration. If ...
https://www.biospace.com/article/releases/astellas-and-seagen-announce-positive-topline-results-for-padcev-enfortumab-vedotin-ejfv-with-keytruda-pembrolizumab-as-first-line-treatment-for-advanced-urothelial-cancer/
CIPROFLOXACIN OPHTHALMIC SOLUTION, USP, 0.3% AS BASE - Prescription Drugs
In corneal ulcer studies with frequent administration of the drug, white crystalline precipitates were seen in approximately 17 ... CIPROFLOXACIN OPHTHALMIC SOLUTION, USP, 0.3% AS BASE. Home/CIPROFLOXACIN OPHTHALMIC SOLUTION, USP, 0.3% AS BASE ... Ciprofloxacin ophthalmic solution is a synthetic, sterile, multiple dose, antimicrobial for topical ophthalmic use. ... CIPROFLOXACIN OPHTHALMIC SOLUTION, USP, 0.3% AS BASEDmitri Soroka2018-09-06T09:12:40+00:00 ...
https://www.prescriptiondrugs.com/ciprofloxacin-ophthalmic-solution-usp-0-3-as-base/
DexamethasoneOintmentCyclosporine ophthalmic solutionCorticosteroidsDiseasesPilocarpine ophthalmicSolutionConjunctival erythemaCorneaActive ingredientDrugsSurgerySystemic absorptionDoseLifitegrastInfectionsOralMedicationsXiidra0.05Cequa2022EmulsionCataractManifestationsRestasisIrritationCannulasPhenylephrineDrugTopical administration2020OpticsDropsPatientsCautionHerpesGlaucomaRoutesRoute
Dexamethasone4
  • A decrease of prolactin release after administration of dexamethasone has been observed (Hubina 2002, Risch 1987) , that may decrease milk production mostly in the first post-partum weeks. (e-lactancia.org)
  • Dexamethasone, topical use (ophthalmic, dermatological) ( Safe. (e-lactancia.org)
  • To quantify plasma concentrations of prednisolone and dexamethasone (peripheral and jugular) and cortisol following topical ophthalmic application of 1% prednisolone acetate and 0.1% dexamethasone to healthy adult dogs. (avma.org)
  • Prednisolone and dexamethasone are detected in the plasma of healthy dogs following topical ophthalmic administration 4 times/d with prednisolone concentrations being close to a physiologic dose of orally administered prednisolone. (avma.org)
Ointment4
  • Atropine Sulfate Ophthalmic Ointment, 1% is a sterile topical anticholinergic for ophthalmic use. (drugs.com)
  • Ophthalmic ointment (1% in 1g and 3.5 g sizes). (cdc.gov)
  • Ophthalmic prednisolone comes as a solution (liquid) and a suspension (eye drops) to instill in the eye and as an eye ointment to apply to the eye. (medlineplus.gov)
  • Application of aversives like bitter apple or chloramphenicol ophthalmic ointment is sometimes done. (vetinfo.com)
Cyclosporine ophthalmic solution2
  • A generic version of the active cyclosporine ingredient is also available, known as cyclosporine ophthalmic solution. (verywellhealth.com)
  • Cequa cyclosporine ophthalmic solution to answer to work with life pharmacy products across categories-5pm. (amazonaws.com)
Corticosteroids3
  • Medical optimization may involve increasing the patient's inhaler regimen, administration of antibiotics (if infection is suspected), administration of corticosteroids to reduce inflammation, and/or chest physiotherapy to manage secretions. (aao.org)
  • Loteprednol, as with other ophthalmic corticosteroids, is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures. (kjhbazar.com)
  • It is Pregnancy Category C. It is not known whether topical ophthalmic administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. (kjhbazar.com)
Diseases2
  • Conclusions and Relevance: With appropriate attention to safety and effectiveness, digital health technology could improve screening and treatment of ophthalmic diseases and improve access to care. (elsevier.com)
  • One such researcher is Mark S. Humayun, MD, PhD. While he has a whole list of inventions, accomplishments, publications and patents to his name, most patients with chronic eye diseases will appreciate his latest invention of the Ophthalmic MicroPump™ System. (enhancedvision.com)
Pilocarpine ophthalmic1
  • To date, Stokes Healthcare Inc. has received 8 complaints of eye irritation, a common side effect of pilocarpine ophthalmic solution. (fda.gov)
Solution29
  • ELESTAT® (epinastine HCl ophthalmic solution) 0.05% is a clear, colorless, sterile isotonic solution containing epinastine HCl, an antihistamine and an inhibitor of histamine release from the mast cell for topical administration to the eyes. (rxlist.com)
  • ELESTAT® ophthalmic solution is indicated for the prevention of itching associated with allergic conjunctivitis . (rxlist.com)
  • These highlights do not include all the information needed to use TRAVOPROST OPHTHALMIC SOLUTION (Ionic Buffered Solution) safely and effectively. (nih.gov)
  • See full prescribing information for TRAVOPROST OPHTHALMIC SOLUTION (Ionic Buffered Solution). (nih.gov)
  • Travoprost ophthalmic solution 0.004% (ionic buffered solution) is a prostaglandin analog indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. (nih.gov)
  • Travoprost ophthalmic solution 0.004% (ionic buffered solution) should not be administered more than once daily since it has been shown that more frequent administration of prostaglandin analogs may decrease the IOP lowering effect. (nih.gov)
  • Travoprost ophthalmic solution 0.004% (ionic buffered solution) may be used concomitantly with other topical ophthalmic drug products to lower IOP. (nih.gov)
  • Travoprost ophthalmic solution has been reported to cause changes to pigmented tissues. (nih.gov)
  • Xiidra® (lifitegrast ophthalmic solution) 5% is indicated for the treatment of signs and symptoms of dry eye disease (DED). (xiidra-ecp.com)
  • Discovery and development of potent LFA-1/ICAM-1 antagonist SAR 1118 as an ophthalmic solution for treating dry eye. (xiidra-ecp.com)
  • Stokes Healthcare Inc. is voluntarily recalling 1 lot of 81 units of Pilocarpine 0.1% Ophthalmic Solution, to the consumer and veterinarian office levels. (fda.gov)
  • The ophthalmic solution has been found to contain a higher level of the preservative benzalkonium chloride than is typical. (fda.gov)
  • Consumers and veterinarian offices that have the Pilocarpine 0.1% ophthalmic solution that is being recalled should stop using the product immediately and contact Stokes Healthcare Inc. to arrange for return and replacement. (fda.gov)
  • Lifitegrast ophthalmic solution 5% (Xiidra) is labeled for the treatment of dry eye disease, also known as keratoconjunctivitis sicca. (aafp.org)
  • Viroptic Ophthalmic Solution, 1% Sterile (trifluridine ophthalmic solution) is an antiviral drug. (centerwatch.com)
  • Instill one drop of Viroptic Ophthalmic Solution, 1% onto the cornea of the affected eye every 2 hours while awake for a maximum daily dosage of nine drops until the corneal ulcer has completely re-epithelialized. (centerwatch.com)
  • This ophthalmic solution with cyclosporine has a strength of 0.9 milligrams per milliliter (mL). (verywellhealth.com)
  • Ciprofloxacin ophthalmic solution is a synthetic, sterile, multiple dose, antimicrobial for topical ophthalmic use. (prescriptiondrugs.com)
  • A topical overdose of ciprofloxacin ophthalmic solution may be flushed from the eye(s) with warm tap water. (prescriptiondrugs.com)
  • As a sterile ophthalmic solution in natural low density polyethylene bottle and dispensing plug and tan polypropylene closure. (prescriptiondrugs.com)
  • Caution should be exercised when Bromfenac ophthalmic solution is administered to a nursing mother. (lifesaverpharma.com)
  • It is recommended that Bromfenac ophthalmic solution be used with caution in patients with known bleeding tendencies or who are receiving other medications which may prolong bleeding time. (lifesaverpharma.com)
  • Bromfenac ophthalmic solution should not be administered while wearing contact lenses. (lifesaverpharma.com)
  • Bromfenac ophthalmic solution contains Sodium Sulfite, a compound that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. (lifesaverpharma.com)
  • Ophthalmic metipranolol comes as a solution (liquid) to instill in the eyes. (medlineplus.gov)
  • Careprost 3ml is a lash serum, It contains an active ingredient of 0.03% bimatoprost ophthalmic solution that is used treating hypotrichosis, Glaucoma, and eyelash growth. (careprost.store)
  • Careprost is a Bimatoprost ophthalmic solution that has helped numerous individuals enhance the look of their eyelashes. (careprost.store)
  • Careprost is available in a 0.03% bimatoprost ophthalmic solution. (careprost.store)
  • Careprost Bimatoprost ophthalmic solution 0.03% is generally safe and well-tolerated, but there are a few things to remember before using it. (careprost.store)
Conjunctival erythema1
  • Lid itching, swelling and conjunctival erythema (ophthalmic). (mims.com)
Cornea1
  • Available at http://www.zeiss.com/meditec/en_de/products---solutions/ophthalmology-optometry/cornea-refractive/laser-treatment/femtosecond-laser-solutions/relex.html#product-information . (medscape.com)
Active ingredient1
  • ICUI ) and Mobius Therapeutics, LLC today jointly announced that ICU Medical's ChemoClave ™ system for the safe handling of hazardous drugs will be packaged with Mobius Therapeutics' Mitosol® kit, an FDA-cleared drug used in ophthalmic surgery containing the active ingredient Mitomycin-C, which is cytotoxic and listed on NIOSH Hazardous Drug List. (prnewswire.com)
Drugs3
  • Elestat belongs to a class of drugs called Antihistamines , Ophthalmic. (rxlist.com)
  • If more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes apart. (nih.gov)
  • A clinical diagnosis of acute herpes zoster on the left ophthalmic branch of the trigeminal nerve was confirmed by a dermatologist, and the patient was treated with acyclovir (400 mg, five times a day) and non-steroidal anti-inflammatory drugs for 1 week. (springeropen.com)
Surgery10
  • A case was defined as corneal endothelial decompensation within 24 hours after surgery in any patient undergoing intraocular ophthalmic surgery during January 5-14, 1998. (cdc.gov)
  • To ascertain cases and to determine the background rate of corneal decompensation, medical records of patients undergoing ophthalmic surgery during September 1997-January 1998 were reviewed. (cdc.gov)
  • In November 1997, the hospital discontinued using ethylene oxide to sterilize instruments used in ophthalmic surgery and began using the Abtox Plazlyte sterilization method (1,2). (cdc.gov)
  • From November 5, 1997, through January 14, 1998, a total of 49 patients had ophthalmic surgery that involved instruments sterilized in the Abtox Plazlyte machine. (cdc.gov)
  • Instruments routinely used in ophthalmic surgery often have small hinges and small lumens. (cdc.gov)
  • Evidence Review: This article presents a summary of the presentations, discussions, and literature review that occurred during a joint Ophthalmic Digital Health workshop of the American Academy of Ophthalmology, the American Academy of Pediatrics, the American Association for Pediatric Ophthalmology and Strabismus, the American Society of Cataract and Refractive Surgery, the American Society of Retina Specialists, the Byers Eye Institute at Stanford and the US Food and Drug Administration. (elsevier.com)
  • Mobius Therapeutics is an early stage venture focused on ophthalmic surgery solutions. (prnewswire.com)
  • Ophthalmic surgery is usually performed with the patient under local sedation, is of short duration relative to thoracic and abdominal surgery, and doesn't result in pain for the patient, obviating the need for postoperative opioids that limit pulmonary risks. (aao.org)
  • however, "stress-dose" glucocorticoid administration is generally unnecessary prior to ophthalmic surgery. (aao.org)
  • In response to widespread reports of problems with LASIK eye surgery, the Food and Drug Administration (FDA) called a Special Hearing of the Ophthalmic Devices Panel on April 25, 2008 to address post-LASIK issues such as poor visual outcomes, debilitating post-LASIK dry eye, loss of quality of life, depression, suicidal thoughts, and a number of LASIK-related suicides . (lasiknewswire.com)
Systemic absorption1
  • The adverse effects of topical steroid administration to the eye are well known and include glaucoma, cataract, exacerbation of corneal infection, and systemic effects secondary to systemic absorption. (bmj.com)
Dose1
  • An increase in heart rate of about 35 beats/minute (which is usually not noticed by the recipient) within 3-5 minutes of an I.V. dose, and a maximal increase in heart rate of about 35-45 beats/minute with I.M. or autoinjector administration, respectively, within about 35-45 minutes (the longer being with I.M. injection). (cdc.gov)
Lifitegrast1
  • 2 Lifitegrast is not systemically detectable despite long-term administration, making systemic effects unlikely. (aafp.org)
Infections1
  • The clinical efficacy of Viroptic in the treatment of stromal keratitis and uveitis due to herpes simplex virus or ophthalmic infections caused by vacciniavirus and adenovirus has not been established by well-controlled clinical trials. (centerwatch.com)
Oral2
  • Oral drug delivery is a widely used route of drug administration, which has been studied for systematic delivery via several pharmaceutical products in different dosage forms. (grandviewresearch.com)
  • The total recommended dosage for oral administration is 2 mg/kg (0.91 mg/lb) of body weight twice daily. (lambertvetsupply.com)
Medications1
  • Students apply basic pharmacodynamics to identifying common medications, medication preparation, and administration of medications used by the major body systems. (gtc.edu)
Xiidra1
  • Contact lenses should be removed prior to the administration of Xiidra and may be reinserted 15 minutes following administration. (xiidra-ecp.com)
0.052
  • To compare the efficacy and safety of cyclosporin A ([CsA] 0.05% and 0.1% ophthalmic emulsions) to vehicle in patients with moderate to severe dry eye disease. (nih.gov)
  • The novel ophthalmic formulations CsA 0.05% and 0.1% were safe and effective in the treatment of moderate to severe dry eye disease yielding improvements in both objective and subjective measures. (nih.gov)
Cequa1
  • In addition to Cequa, the ophthalmic cyclosporine Restasis may also be prescribed in cases of dry eye caused by tear deficiency. (verywellhealth.com)
20221
  • This narrative review creates a primer for the ophthalmologist of clinically relevant information regarding monkeypox, its ophthalmic manifestations, and the 2022 outbreak. (ama-assn.org)
Emulsion1
  • Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. (nih.gov)
Cataract1
  • 6 Cataract may also result from topical administration, and a dosage of one drop of topical steroid a day for one year is sufficient to cause cataract formation. (bmj.com)
Manifestations1
  • Monkeypox ophthalmic manifestations may present to the ophthalmologist, or the ophthalmologist may be involved in comanagement. (ama-assn.org)
Restasis2
  • This is similar to cyclosporine ophthalmic (Restasis), which costs approximately $529 for a one-month supply (one 5.5-mL bottle). (aafp.org)
  • Restasis was the first cyclosporine drop to be approved by the Food and Drug Administration (FDA). (verywellhealth.com)
Irritation2
  • A good adjunct to this type of therapy appears to be administration of hydrocodone to cut down on the irritation and/or fill the need for endorphins that the dog may be experiencing. (vetinfo.com)
  • It is used in ophthalmic solutions for the relief of burning, irritation and/or discomfort that follows dryness of the eye 7 . (drugbank.com)
Cannulas1
  • In addition, ophthalmic cannulas (small-lumen instruments) may have nickel- and chrome-plated brass hubs. (cdc.gov)
Phenylephrine9
  • amitriptyline, phenylephrine ophthalmic. (medscape.com)
  • amoxapine, phenylephrine ophthalmic. (medscape.com)
  • clomipramine, phenylephrine ophthalmic. (medscape.com)
  • desipramine, phenylephrine ophthalmic. (medscape.com)
  • doxepin, phenylephrine ophthalmic. (medscape.com)
  • imipramine, phenylephrine ophthalmic. (medscape.com)
  • isocarboxazid increases effects of phenylephrine ophthalmic by pharmacodynamic synergism. (medscape.com)
  • linezolid increases effects of phenylephrine ophthalmic by pharmacodynamic synergism. (medscape.com)
  • He soon became hypotensive, requiring administration of phenylephrine and esmolol, with resolution but continued tachycardia responsive to adenosine. (eyeanesthesia.org)
Drug17
  • The Abtox Plazlyte system has not been cleared by the Food and Drug Administration (FDA) for either safety or performance. (cdc.gov)
  • 3. US Food and Drug Administration. (xiidra-ecp.com)
  • This recall is being conducted with the knowledge of the U.S. Food and Drug Administration. (fda.gov)
  • Dr Chodosh reported receiving consultant fees from the US Food and Drug Administration outside the submitted work. (ama-assn.org)
  • the refractive and corneal indications are awaiting approval by the Food and Drug Administration. (prnewswire.com)
  • The U.S. Food and Drug Administration announced a Class I recall of lot no. (dotmed.com)
  • In February 2020, the U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy designation for enfortumab vedotin in combination with pembrolizumab for patients with unresectable la/mUC who are ineligible to receive cisplatin-based chemotherapy in the first-line setting. (biospace.com)
  • In corneal ulcer studies with frequent administration of the drug, white crystalline precipitates were seen in approximately 17% of patients (SEE PRECAUTIONS ). (prescriptiondrugs.com)
  • Teprotumumab is the first and only medication approved by the United States Food and Drug Administration for the treatment of TED. (dovepress.com)
  • Teprotumumab is a fully human monoclonal IgG1 antibody against IGF-IR, 11 and is the only medication thus far approved by the United States (US) Food and Drug Administration (FDA) for TED. (dovepress.com)
  • however, it is important to note that the Aricept (donepezil HCl) 23 mg tablet has been approved by the U.S. Food and Drug Administration for the treatment of moderate-to-severe Alzheimer's disease. (cnn.com)
  • Plasma cortisol concentrations were measured at the beginning of the study and following topical drug administration. (avma.org)
  • The global drug delivery technology market can be segmented in terms of route of administration, end-user, and region. (medgadget.com)
  • U.S. Food and Drug Administration. (medscape.com)
  • These results were communicated to the Food that may lead to vision loss or enucleation, is caused by and Drug Administration (FDA) and were rapidly dissemi- the ubiquitous free-living Acanthamoeba spp. (cdc.gov)
  • Life pharmacy benefit managers pbms negotiate prescription drug administration fda regulations and discussions about lb4.3 billion on 3 sources: 760 872-3935 mon-181 pages 3 reviewsthis book examines the feel the issue of ingredients. (amazonaws.com)
  • Are IOLs approved by the Food and Drug Administration (FDA) USA? (eyeacuity.com)
Topical administration4
  • 2001) (Although, it does respond to topical administration). (cdc.gov)
  • In other clinical studies, Viroptic was evaluated in the treatment of herpes simplex virus keratitis in patients who were unresponsive or intolerant to the topical administration of idoxuridine or vidarabine. (centerwatch.com)
  • Since Loteprednol Etabonate is not detected in plasma following the topical administration, it is not expected to affect the pharmacokinetics of systemically administered medicinal products. (kjhbazar.com)
  • Aganirsen is an antisense oligonucleotide which topical administration inhibits the production of VEGF, which plays a major role in the pathogenesis of NVG. (europa.eu)
20201
  • Il s'agissait d'une étude rétrospective descriptive d'une durée de 2 ans 3 mois allant du 1er janvier 2018 au 31 Mars 2020 portant sur 80 dossiers de malades porteurs d'hémopathies malignes et prise en charge dans le centre. (bvsalud.org)
Optics1
  • UD30654 of Healon D, an ophthalmic viscosurgical device (OVD) manufactured by Advanced Medical Optics Inc. (AMO) of Santa Ana, Calif. (dotmed.com)
Drops2
  • Lenses should not be reinserted until at least 15 minutes after administration of the drops. (aafp.org)
  • The objective of the study is to evaluate the effectiveness and safety of olopatadine 0.1% ophthalmic drops with bepotastine besilate 1.5% ophthalmic drops in patients with vernal keratoconjunctivitis (VKC). (ijp-online.com)
Patients5
  • Today, the AbdulRazaq administration has delivered a 12-bed ICU that is not just the largest in central Nigeria but is equipped with modern gadgets that include ventilators, patient monitors, defibrillators, syringe pump, suction machines, infusion pumps, and appropriate ICU beds, among other medical tools required to manage patients in critical condition. (sunnewsonline.com)
  • Methods Based on the potential for the ophthalmic artery (OA) to be an anatomical target for the treatment of AMD as outlined above, five patients were found to be eligible for compassionate use treatment, presenting clinically significant late-stage AMD with profound vision loss in one or both eyes, and are included in this retrospective study. (bmj.com)
  • We observed that nasopharyngeal airway insertion is a safe and effective procedure in selective group of patients, for ophthalmic surgeries under local anesthesia with sedation. (eyeanesthesia.org)
  • Le protocole utilisé dans le traitement du myélome multiple a été le VMCD-REV à 76,92% avec pour réponse thérapeutique complète chez 6 patients, 3 réponses partielles et 4 en cours de traitement. (bvsalud.org)
  • At Acuity Eye Centre, we are committed to providing all of our patients with the most complete ophthalmic services available. (eyeacuity.com)
Caution1
  • Administration of atropine in infants requires great caution. (drugs.com)
Herpes1
  • An 82-year-old man presented with severe chronic itching in the ophthalmic branch of the left trigeminal nerve dermatome, following acute herpes zoster. (springeropen.com)
Glaucoma3
  • 3,4 We report a case of steroid induced glaucoma and cataracts (with irreversible visual loss) following prolonged unsupervised administration of topical steroid eyedrops. (bmj.com)
  • The cause of this patient's glaucoma and cataracts was chronic steroid administration without ophthalmic supervision. (bmj.com)
  • Ophthalmic metipranolol is used to treat glaucoma, a condition in which increased pressure in the eye can lead to gradual loss of vision. (medlineplus.gov)
Routes1
  • Preferred routes of administration of atropine. (cdc.gov)
Route1
  • Nous avons cependant des difficultés quant à la mise en route de la chimiothérapie. (bvsalud.org)
(emedicine.medscape.com)
Acute Angle-Closure Glaucoma in Emergency Medicine Medication: Carbonic anhydrase inhibitors, Beta-adrenergic blockers, Alpha...
Acute Angle-Closure Glaucoma in Emergency Medicine Medication: Carbonic anhydrase inhibitors, Beta-adrenergic blockers, Alpha... (emedicine.medscape.com)
DailyMed - SENSORCAINE- bupivacaine hydrochloride injection, solution SENSORCAINE MPF- bupivacaine hydrochloride and...
DailyMed - SENSORCAINE- bupivacaine hydrochloride injection, solution SENSORCAINE MPF- bupivacaine hydrochloride and... (dailymed.nlm.nih.gov)
Pseudomonas aeruginosa Infections Treatment & Management: Approach Considerations, Medical Care, Surgical Care
Pseudomonas aeruginosa Infections Treatment & Management: Approach Considerations, Medical Care, Surgical Care (medscape.com)
Ophthalmic Surgery: What's Hot Outside the United States
Ophthalmic Surgery: What's Hot Outside the United States (medscape.com)
GFA First Aid Kit
GFA First Aid Kit (dailymed.nlm.nih.gov)
Cequa: Uses, Side Effects, Dosages, Precautions
Cequa: Uses, Side Effects, Dosages, Precautions (verywellhealth.com)
Lyme Disease Clinical Presentation: History, Physical Examination
Lyme Disease Clinical Presentation: History, Physical Examination (medscape.com)
Atropine Sulfate Ophthalmic Ointment: Package Insert / Prescribing Information - Drugs.com
Atropine Sulfate Ophthalmic Ointment: Package Insert / Prescribing Information - Drugs.com (drugs.com)
Research Articles and Publications | CDC
Research Articles and Publications | CDC (cdc.gov)
Fluocinonide Cream USP, 0.05% For External Use Only. Not For Ophthalmic Use. ...
Fluocinonide Cream USP, 0.05% For External Use Only. Not For Ophthalmic Use. ... (dailymed.nlm.nih.gov)
Betamethasone Dipropionate Cream USP, 0.05%(Potency expressed as betamethasone)FOR DERMATOLOGIC USE ONLY.NOT FOR OPHTHALMIC USE.
Betamethasone Dipropionate Cream USP, 0.05%(Potency expressed as betamethasone)FOR DERMATOLOGIC USE ONLY.NOT FOR OPHTHALMIC USE. (dailymed.nlm.nih.gov)
Triamcinolone Acetonide Ointment USP FOR EXTERNAL USE ONLY.NOT FOR OPHTHALMIC USE. Rx Only
Triamcinolone Acetonide Ointment USP FOR EXTERNAL USE ONLY.NOT FOR OPHTHALMIC USE. Rx Only (dailymed.nlm.nih.gov)
Nystop® Nystatin Topical Powder, USP Rx Only For topical use only.Not for ophthalmic use.
Nystop® Nystatin Topical Powder, USP Rx Only For topical use only.Not for ophthalmic use. (dailymed.nlm.nih.gov)
Halobetasol Propionate Ointment, 0.05% For Dermatological Use Only. Not for Ophthalmic Use ...
Halobetasol Propionate Ointment, 0.05% For Dermatological Use Only. Not for Ophthalmic Use ... (dailymed.nlm.nih.gov)
For Dermatologic Use Only Not for Ophthalmic Use Rx Only
For Dermatologic Use Only Not for Ophthalmic Use Rx Only (dailymed.nlm.nih.gov)
NYSTATIN AND TRIAMCINOLONE ACETONIDE cream, USP Rx only FOR EXTERNAL USE ONLY. NOT FOR OPHTHALMIC USE.
NYSTATIN AND TRIAMCINOLONE ACETONIDE cream, USP Rx only FOR EXTERNAL USE ONLY. NOT FOR OPHTHALMIC USE. (dailymed.nlm.nih.gov)
Nystatin and Triamcinolone Acetonide Ointment, USP Rx only FOR EXTERNAL USE ONLY NOT FOR OPHTHALMIC USE
Nystatin and Triamcinolone Acetonide Ointment, USP Rx only FOR EXTERNAL USE ONLY NOT FOR OPHTHALMIC USE (dailymed.nlm.nih.gov)
Rx only FOR TOPICAL DERMATOLOGIC USE ONLY - NOT FOR OPHTHALMIC, ORAL OR INTRAVAGINAL USE.
Rx only FOR TOPICAL DERMATOLOGIC USE ONLY - NOT FOR OPHTHALMIC, ORAL OR INTRAVAGINAL USE. (dailymed.nlm.nih.gov)
Cortef® hydrocortisone cypionateoral suspension
Cortef® hydrocortisone cypionateoral suspension (dailymed.nlm.nih.gov)
Financial Return-on-Investment of Ophthalmic Interventions
Financial Return-on-Investment of Ophthalmic Interventions (medscape.com)
Bacitracin Zinc and Polymyxin B Sulfate Ophthalmic Ointment, USP (Sterile) Rx only
Bacitracin Zinc and Polymyxin B Sulfate Ophthalmic Ointment, USP (Sterile) Rx only (dailymed.nlm.nih.gov)
(emedicine.medscape.com)