Drug Administration Schedule
United States Food and Drug Administration
Drug Administration Routes
Dose-Response Relationship, Drug
Rats, Sprague-Dawley
Rats, Wistar
Injections, Intraperitoneal
Disease Models, Animal
Injections, Subcutaneous
Administration, Rectal
Liver
Biological Availability
Injections, Intramuscular
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Infusions, Intravenous
Half-Life
Drug Interactions
Area Under Curve
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Rats, Inbred Strains
Administration, Cutaneous
Tissue Distribution
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Dogs
Double-Blind Method
Cross-Over Studies
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Treatment Outcome
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Administration, Inhalation
Kidney
Infusions, Parenteral
Body Weight
Random Allocation
Drug Tolerance
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
Morphine
Plant Extracts
Analysis of Variance
Injections, Spinal
Metabolic Clearance Rate
Chromatography, High Pressure Liquid
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Rabbits
Lung
Analgesics, Opioid
Self Administration
Ethanol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Pregnancy
Estradiol
Drug Combinations
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Hemodynamics
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Drug Evaluation, Preclinical
Drug Therapy, Combination
Enzyme Inhibitors
Administration, Buccal
Prodrugs
Drug Approval
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Naloxone
Dopamine
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Genetic Therapy
Nitric Oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Hydrocortisone
Absorption
Cells, Cultured
Lipopolysaccharides
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Immunohistochemistry
Delayed-Action Preparations
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Pain Measurement
Pain
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Testosterone
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Microdialysis
Progesterone
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Genetic Vectors
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Growth Hormone
Administration, Intravaginal
Inflammation
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Antioxidants
Models, Animal
Drug Delivery Systems
Bile
United States Department of Veterans Affairs
Gonadotropin-Releasing Hormone
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
Drugs, Chinese Herbal
Pyridines
Luteinizing Hormone
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Diabetes Mellitus, Experimental
Neoplasms, Experimental
Prospective Studies
Mice, Nude
Device Approval
Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.
Mice, Transgenic
Neoplasm Transplantation
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Infusion Pumps
Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.
Pyrazoles
Glucocorticoids
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Methamphetamine
Serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Norepinephrine
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Neoplasms
Diazepam
Corticosterone
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Anesthesia
Chemistry, Pharmaceutical
Adrenocorticotropic Hormone
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Drug Carriers
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Central Nervous System Stimulants
Hyperalgesia
Neuroprotective Agents
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Leukocyte Count
Hypnotics and Sedatives
Gene Expression
Analgesics, Non-Narcotic
Intestines
Haloperidol
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
Drug-Induced Liver Injury
Imidazoles
Anti-Anxiety Agents
Indomethacin
Brain Chemistry
Placebos
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
Suppositories
Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
Hypothalamus
Gene Expression Regulation
Substance Withdrawal Syndrome
Adenoviridae
Iodine Radioisotopes
Edema
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Neurons
Nitric Oxide Synthase
Infusion Pumps, Implantable
Implanted fluid propulsion systems with self-contained power source for providing long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristatically controlled with the aid of transcutaneous monitoring.
Chorionic Gonadotropin
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
Feces
Blotting, Western
Narcotics
Oxidative Stress
Clinical Trials as Topic
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Erythropoietin
Endotoxins
Sheep
Immunoglobulin G
Myocardium
Nicotine
Amphetamine
A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
Injections, Intradermal
Corpus Striatum
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
Intestinal Mucosa
Homing of stem cells to sites of inflammatory brain injury after intracerebral and intravenous administration: a longitudinal imaging study. (1/222)
(+info)Intravenous therapies for castration-resistant prostate cancer: toxicities and adverse events. (2/222)
(+info)Population pharmacokinetic and pharmacodynamic model-based comparability assessment of a recombinant human Epoetin Alfa and the Biosimilar HX575. (3/222)
(+info)Variability in the use of intravenous thrombolysis for mild stroke: experience across the SPOTRIAS network. (4/222)
(+info)Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine. (5/222)
(+info)A novel vitamin K1 2,3-epoxide reductase (VKOR) inhibitor, 3-acetyl-5-methyltetronic acid, reduces experimental glomerulonephritis. (6/222)
Excessive proliferation of mesangial cells is observed in various types of glomerular disease including glomerulonephritis (GN), which is progressive in nature and eventually results in end-stage renal disease (ESRD). Vitamin K(1) 2,3-epoxide reductase (VKOR) and the vitamin K-dependent growth arrest-specific gene 6/Axl pathway play a key role in mesangial cell proliferation in GN. In the present study, we indicate the potential of a VKOR inhibitor, 3-acetyl-5-methyltetronic acid (AMT), to prevent the proliferation of glomerular mesangial cells and suppress the progression of GN. AMT was administered intravenously to rats once daily for 12 days and a mouse anti-Thy1 monoclonal antibody was injected intravenously after the AMT treatment on Day 6. Creatinine clearance (CCr) significantly increased and the albumin-to-creatinine ratio (ACR) significantly decreased in the AMT-treated group of the Thy-1 GN rats. In addition, glomerular and tubular damage was improved histopathologically in the AMT-treated group. AMT did not affect blood coagulation due to its unique pharmacokinetic properties. The concentration of AMT reached the IC(50) for VKOR in kidney, but not in liver. A novel VKOR inhibitor, AMT, reduced renal mesangial cell proliferation and could be a supportive treatment for GN. (+info)Population pharmacokinetic model of canrenone after intravenous administration of potassium canrenoate to paediatric patients. (7/222)
(+info)Paricalcitol versus cinacalcet plus low-dose vitamin D therapy for the treatment of secondary hyperparathyroidism in patients receiving haemodialysis: results of the IMPACT SHPT study. (8/222)
(+info)
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Intravenous ascorbic acid
According to the U.S. Food and Drug Administration (FDA), high-dose vitamin C (such as intravenous ascorbic acid therapy) has ... Mikirova N, Casciari J, Riordan N, Hunninghake R (August 2013). "Clinical experience with intravenous administration of ... The use of intravenous ascorbic acid in the treatment of cancer has been a contentious issue. There is no evidence to indicate ... The use of intravenous ascorbic acid as a proposed cancer treatment or co-treatment has been a controversial topic since the ...
Y-Set (intravenous therapy)
Intravenous fluids, Medical equipment, Routes of administration). ... In intravenous therapy a Y-Set, T-Set and V-Sets are Y, T and V shaped three-way connector sets made of connecting plastic ... to a short common limb attached to the female fitting on the intravenous cannulae. 3-way connectors allow for "piggybacking", ... tubes used for delivering intravenous drugs into the body from multiple fluid sources. As Y-Sets are the most common shaped ...
Total intravenous anaesthesia
Total intravenous anesthesia (TIVA) refers to the intravenous administration of anesthetic agents to induce a temporary loss of ... Secondly, intravenous delivery may be impaired by lax monitoring of the intravenous catheter and the insertion site. Thirdly, ... Engbers, Frank H. M. (2000), "Total Intravenous Anaesthesia: The Equipment", On the Study and Practice of Intravenous ... Sepúlveda V., Pablo O.; Cortínez, Luis Ignacio (2017), "Intravenous Anesthesia in Obese Patients", Total Intravenous Anesthesia ...
Intravenous iron infusion
Auerbach, M., Ballard, H. (2010). 'Clinical Use of Intravenous Iron: Administration, Efficacy, and Safety,' ASH Education Book ... In intravenous iron infusions, free iron has been shown to potentiate bacterial growth. Evidence associated with intravenous ... These findings show that intravenous iron has a broad use to many patients where anaemia is an underlying issue. Intravenous ... The intravenous method is a fast and effective way of delivering iron throughout the body, and is used because iron can be ...
Potomac horse fever
... intravenous dimethyl sulfoxide; administration of products such as Biosponge or activated charcoal via nasogastric tube to bind ... This may include intravenous fluids and electrolytes to counteract the diarrhea; NSAIDs such as Banamine (flunixin meglumine); ... Mild cases may be treated with oral doxycycline, while severe cases are usually treated with intravenous oxytetracycline. ... Experimental infection has been produced with oral administration of infected insects and subcutaneous inoculation of N. ...
Immunoglobulin therapy
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Metaraminol
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Sipuleucel-T
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Piflufolastat F-18
It is the second PSMA-targeted PET imaging drug approved by the U.S. Food and Drug Administration (FDA). The first approved ... It is given by intravenous injection. The most common adverse reactions include headache, altered taste, and fatigue. ... "FDA approves PSMA-targeted imaging drug for men with prostate cancer". U.S. Food and Drug Administration (FDA). 27 May 2021. ... The U.S. Food and Drug Administration (FDA) granted approval of Pylarify to Progenics Pharmaceuticals, Inc. "Pylarify- ...
Peramivir
It is approved for intravenous administration. In October 2009, the U.S. Food and Drug Administration (FDA) issued an emergency ... for intravenous peramivir in December 2013. Peramivir (Rapivab) was approved for intravenous administration in December 2014. " ... effective in intravenous treating 8 serious cases of swine flu. On October 23, the U.S. Food and Drug Administration (FDA) ... "Peramivir: Requirements for Administration under EUA". Lifehugger. Archived from the original on 2011-07-13. "CDC H1N1 Flu - ...
Ocrelizumab
It was approved by the U.S. Food and Drug Administration (FDA) in March 2017, and the first FDA approved drug for the primary ... It is administered by intravenous infusion. In the EU, ocrelizumab is indicated for the treatment of adults with relapsing ... The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. In the US, ocrelizumab is indicated ... "BLA Approval Letter" (PDF). U.S. Food and Drug Administration (FDA). March 28, 2017. New Drug Therapy Approvals 2017 (PDF). U.S ...
VX (nerve agent)
"Intravenous Administration of VX in Man". Archived from the original on March 26, 2017. Retrieved 2017-03-25.{{cite web}}: CS1 ... Van M. Sim underwent an intravenous infusion of VX to evaluate its effects and to establish a baseline for future ... After approximately 3.5 hours following initial administration of the agent, Sim suddenly became pale and delirious. The ...
Intravenous sodium bicarbonate
Rapid administration (equal to or exceeding 10 mL/min) of intravenous sodium bicarbonate into neonates and children under two ... Norepinephrine and dobutamine cannot be used as additives in an intravenous sodium bicarbonate solution. Intravenous sodium ... Intravenous medical use began around the 1950s. It is on the World Health Organization's List of Essential Medicines. Sodium ... Intravenous sodium bicarbonate is indicated in the treatment of metabolic acidosis, such as can occur in severe kidney disease ...
Phenylephrine
"Vazculep Package Insert" (PDF). U.S. Food and Drug Administration. Shih JC, Chen K (August 2004). "Regulation of MAO-A and MAO- ... The clinical effects of a single intravenous bolus dose of phenylephrine are short lived and needs to be repeated every 10-15 ... Commonly the drug is given as a carefully titrated intravenous infusion with a syringe pump or volumetric pump. Because of its ... Compared to intravenous pseudoephedrine, phenylephrine has a reduced and variable bioavailability; only up to 38%. " ...
Anidulafungin
Food and Drug Administration. 2006-02-21. Archived from the original on 10 July 2009. Retrieved 2009-08-01. (Webarchive ... "Eraxis (anidulafungin) for Injection, for Intravenous Use. Full Prescribing Information". Roerig (Division of Pfizer, Inc.), ... Trissel LA and Ogundele AB, "Compatibility of Anidulafungin With Other Drugs During Simulated Y-Site Administration,"Am J ... Pfizer gained approval by the Food and Drug Administration (FDA) on February 21, 2006. "International Nonproprietary Names for ...
Amrinone
Currently, only acute intravenous administration takes place. The effects of amrinone vary widely with species and experimental ... An IV administration of amrinone has been shown to increase cardiac output (CO) and stroke volume (SV), while concurrently ... Klein N.A.; Siskind S.J.; Frishman W.H.; Sonnelblick E.H.; LeJemtel T.H. (1981). "Hemodynamic Comparison of Intravenous ... An increase in cAMP with the administration of amrinone in vascular smooth muscle produces vasodilation by facilitating calcium ...
Nitroglycerin
"Association of methemoglobinemia and intravenous nitroglycerin administration". American Journal of Cardiology. 55 (1): 181-183 ... The Occupational Safety and Health Administration has set the legal limit (permissible exposure limit) for nitroglycerin ... Nitroglycerin is available in tablets, ointment, solution for intravenous use, transdermal patches, or sprays administered ...
Metronidazole
Intravenous administration is commonly associated with thrombophlebitis. Infrequent adverse effects include: hypersensitivity ... suppositories and intravenous administration". Scandinavian Journal of Gastroenterology. Supplement. 91: 45-60. PMID 6588489. ... The U.S. Food and Drug Administration (FDA) suggests it only be used when necessary because it has been shown to be ... The serum half-life of hydroxymetronidazole after suppository was 10 hours, 19 hours after intravenous infusion, and 11 hours ...
Nitroglycerin (medication)
"Association of methemoglobinemia and intravenous nitroglycerin administration". The American Journal of Cardiology. 55 (1): 181 ... Continuous administration and absorption (such as provided by daily pills and especially skin patches) accelerate onset of ...
Purple glove syndrome
"Purple glove syndrome following intravenous phenytoin administration". Vasc Med. 12 (1): 29-31. doi:10.1177/1358863X07076551. ... Onset is generally seen within the first few hours of administration. The true pathology of purple glove syndrome is not fully ... PGS is most common among elderly patients and those receiving multiple large intravenous doses of the epilepsy drug phenytoin. ... This may occur due to the administration of phenytoin with or without extravasation. The defining characteristic is a purplish ...
Absorption (pharmacology)
Absorption is the journey of a drug travelling from the site of administration to the site of action. The drug travels by some ... A common example is bolus intravenous injection. Zero-order absorption: rate of absorption is constant. A common example is ... Representative examples include typical cases of oral administration, subcutaneous injection, and intramuscular injection. ... Intravascular administration does not involve absorption, and there is no loss of drug. The fastest route of absorption is ...
Group B streptococcal infection
Administration of intravenous (IV) antibiotics during labour. Intravenous penicillin or ampicillin given at the onset of labour ... Where insufficient intravenous antibiotics are given before delivery, the baby may be given antibiotics immediately after birth ... If the woman has a severe allergy to beta-lactams then intravenous vancomycin (1 g every 12 hours) is recommended. Neither ... Currently, the only reliable way to prevent GBS-EOD is administration of intrapartum antibiotics before delivery, that is to ...
Route of administration
Intravaginal administration, in the vagina. Intravenous (into a vein), e.g. many drugs, total parenteral nutrition. ... Common examples include oral and intravenous administration. Routes can also be classified based on where the target of action ... Oral administration is often denoted "PO" from "per os", the Latin for "by mouth". The bioavailability of oral administration ... Comparative biopharmaceutics of diazepam after single rectal, oral, intramuscular and intravenous administration in man". ...
Decompression illness
Administration of intravenous saline solution is preferable. Record details of recent dives and responses to first aid ...
Meloxicam
... after oral administration and a mean volume of distribution at steady-state of 0.2 L/kg after intravenous administration." " ... "Anjeso (meloxicam) injection, for intravenous use" (PDF). U.S. Food and Drug Administration (FDA). February 2020. Archived (PDF ... An intravenous version of meloxicam (Anjeso) was approved for medical use in the United States in February 2020. Meloxicam use ... Perioperative administration of meloxicam to cats did not affect postoperative respiratory rate nor heart rate. A peer-reviewed ...
Giant-cell tumor of bone
The mass enhances after intravenous gadolinium administration. A number of tumors have giant cells, but are not true benign ...
Jason Diamond
Comparing Intranasal Administration to Intramuscular Administration in Healthy Human Volunteers." University of Kentucky ... Intravenous Botorphanol Tartrate In Healthy Human Volunteers." University of Kentucky Chandler Medical Center Protocol BT002. " ...
Packed red blood cells
February 2018). "The administration of blood components: a British Society for Haematology Guideline". Transfusion Medicine. 28 ... Plumer AL (2007). Plumer's Principles and Practice of Intravenous Therapy. Lippincott Williams & Wilkins. p. 423. ISBN ...
Brit milah
Berger, Itai; Steinberg, Avraham (May 2002). "Neonatal mydriasis: intravenous lidocaine adverse reaction". J Child Neurol. 17 ( ... "Generalized seizures following topical lidocaine administration during circumcision: establishing causation". Paediatr Drugs. 9 ...
Pregnancy category
Food and Drug Administration. April 1, 1997. Archived from the original on 2008-03-26. Retrieved 2008-05-21. (All articles with ... Appendix 4 is now titled "Intravenous Additives". However, information that was previously available in the former Appendix 4 ( ... Food and Drug Administration. Federal Register 1980; 44:37434-67 "Specific requirements on content and format of labeling for ... "Prescribing medicines in pregnancy database". Therapeutic Goods Administration (TGA). 2021-04-15. Retrieved 2021-08-16.{{cite ...
Cervical cancer
On 15 June 2006, the US Food and Drug Administration approved the use of a combination of two chemotherapy drugs, hycamtin and ... intravenous urography, and X-ray examination of the lungs and skeleton, and cervical conization. However, the current system ... In 2006, the U.S. Food and Drug Administration (FDA) approved the first preventive HPV vaccine, marketed by Merck & Co. under ... "FDA Approves First Drug Treatment for Late-Stage Cervical Cancer". U.S. Food and Drug Administration. 15 June 2006. Archived ...
Norovirus
Management involves supportive care such as drinking sufficient fluids or intravenous fluids. Oral rehydration solutions are ... polymerase chain reaction are being employed by governmental laboratories such as the Food and Drug Administration (FDA) in the ...
Childbirth
Active management is the administration of a uterotonic drug within one minute of fetal delivery, controlled traction of the ... or with a combination of prostaglandin and intravenous oxytocin treatment. Caesarean section is the removal of the neonate ... Lancashire, Liz (9 July 2018). "Medicine Administration for Midwives". Norfolk and Norwich University Hospitals. Archived from ... but instead to postponing delivery long enough for the administration of glucocorticoids which can help the fetal lungs to ...
Pre-exposure prophylaxis
... intravenous drug users, men who have sex with men) without consistent condom use or anyone who has injected illicit drugs in ... the US Food and Drug Administration (FDA) approved the combination of emtricitabine and tenofovir alafenamide (Descovy) to be ... or has been in treatment for intravenous drug use in the past six months In the United Kingdom the BHIVA/BASHH guidelines on ... people who engage in intravenous drug use (see drug injection), and serodiscordant sexually active couples. When used as ...
2022 monkeypox outbreak
... the General Administration of Customs of the People's Republic of China issued the Announcement on Preventing Monkeypox from ... suggests supportive care may typically be sufficient and that several antivirals and vaccinia immune globulin intravenous ( ... General office of the National Health Commission of the People's Republic of China and the Office of the State Administration ...
Lormetazepam
Repeated administration and transfer to neonates via breast milk". European Journal of Clinical Pharmacology. 21 (5): 421-5. ... June 1996). "Intravenous flumazenil following prolonged exposure to lormetazepam in humans: lack of precipitated withdrawal". ... effects after nighttime administration of lormetazepam such as sleepiness, impaired psychomotor and cognitive functions may ...
John Abner Snell
Under his administration, the Soochow Hospital underwent a large expansion, acquired modern technology, and was held to a very ... They implemented a variety of treatment techniques, primarily intravenous Rogers treatment of saline solution. Snell also ... Additionally, administration obtained a new X-ray machine which greatly improved the hospital's ability for diagnosis. On ... Upon Park's return, the responsibilities were split, leaving Snell responsible for surgery and administration. Main concerns ...
Pembrolizumab
30 May 2017). "FDA D.I.S.C.O.: First Tissue/Site Agnostic Approval Transcript". U.S. Food and Drug Administration (FDA). ... As of 2019[update], pembrolizumab is used via intravenous infusion to treat inoperable or metastatic melanoma, metastatic non- ... "FDA approves pembrolizumab for adults and children with TMB-H solid tumors". U.S. Food and Drug Administration (FDA). 17 June ... "FDA approves first cancer treatment for any solid tumor with a specific genetic feature". U.S. Food and Drug Administration ( ...
Oral candidiasis
... depending on the route of administration. Topically administered corticosteroids in the mouth may take the form of mouthwashes ... may require systemic prevention or treatment with oral or intravenous administered anti-fungals. However, there is strong ...
Levothyroxine
... for systemic administration is available as an oral tablet, an intramuscular injection, and as a solution for ... Levothyroxine is taken by mouth or given by intravenous injection. Maximum effect from a specific dose can take up to six weeks ... According to the U.S. Food and Drug Administration pregnancy categories, levothyroxine has been assigned category A. Given that ... Food and Drug Administration (FDA). 19 November 2020. Portal: Medicine (CS1 German-language sources (de), Articles with short ...
Polyestriol phosphate
Intravenous administration of ovarian hormones offers no advantages, however, and therefore has no practical significance ... The following duarations of action have been obtained with a single administration (WlED, 1954; LAURITZEN, 1968): [...] 50 mg ...
Aspiration pneumonia
The administration of anesthesia causes suppression of protective reflexes, most importantly the gag reflex. As a result, ... ranging from topical antibiotics to intravenous antibiotic use. Whereas the use of antibiotics focuses on destroying and ...
Hyperosmolar syndrome
Following the administration of intravenous insulin, dextrose should be added once glucose levels reach the 250-300mg/dL target ... Treatment involves intravenous fluids to replenish hydration- reducing plasma, intravenous insulin to lower blood sugar levels ... and intravenous potassium and sodium to replace the lost electrolytes which are essential for cell function, as insulin will ...
Oxycodone
... of the analgesic effect of oxycodone after oral and intravenous administration, respectively. Although the CYP2D6 genotype and ... The bioavailability of oral administration of oxycodone averages within a range of 60 to 87%, with rectal administration ... of its analgesic effect following oral and intravenous administration, respectively. Oxymorphone plays only a minor role, being ... Therapeutic Goods Administration (June 2008). Standard for the uniform scheduling of drugs and poisons no. 23 (PDF). Canberra: ...
Lyme disease
Intravenous administration of ceftriaxone is recommended as the first choice in these cases; cefotaxime and doxycycline are ... intravenous and intramuscular penicillin and intravenous ceftriaxone. The mechanism of tick transmission was also the subject ... It was granted fast track designation by the U.S. Food and Drug Administration in July 2017. In April 2020 Pfizer paid $130 ... On 21 December 1998, the Food and Drug Administration (FDA) approved LYMErix on the basis of these trials for persons of ages ...
Pharmacosmos
Its approved by health authorities in Europe, Asia and in the U.S. by Food and Drug Administration (FDA). Pharmacosmos is one ... NCT01145638 Sinha, S.; Kalra, P. (2010). "Treating the Anemic Oncology Patient with Intravenous Iron: Why, When, and How?" (PDF ... Food and Drug Administration (FDA). The company has an ongoing clinical development program aimed at improving treatment ...
Essendon Football Club supplements saga
The program also included supplements in pill form and intravenous vitamin drips. The program was intended to be leading-edge, ... but it had not been approved for human use by the Therapeutic Goods Administration and therefore could be considered as banned ... and many features of the program which were legal at the time, including Tribulus and intravenous vitamin C, were outlawed by ... "deplorable absence of records in the program relating to its administration." Essendon and the AFL discussed and negotiated ...
Doxepin
Slow intravenous administration of physostigmine may reverse some of the toxic effects of overdose such as anticholinergic ... Management of overdose is mostly supportive and symptomatic, and can include the administration of a gastric lavage so as to ... "Sleep Disorder (Sedative-Hypnotic) Drug Information - U.S. FDA". Food and Drug Administration. 13 June 2017. Retrieved 9 August ...
Flumazenil
Intravenous flumazenil is primarily used to treat benzodiazepine overdoses and to help reverse anesthesia. Administration of ... Administration of the drug requires careful monitoring by an anesthesiologist due to potential side effects and serious risks ... Intravenous flumazenil has been shown to antagonize sedation, impairment of recall, psychomotor impairment and ventilatory ... It is available as a clear, colourless solution for intravenous injection, containing 500 μg in 5 mL. Many benzodiazepines ( ...
CX717
In 2005 the U.S. Food and Drug Administration (FDA) accepted Cortex Pharmaceuticals' Investigational New Drug (IND) application ... effects of the ampakine drugs on the pre-Botzinger complex of the brain has led to continued development of an intravenous ... "Brain Vacuolation Resulting From Administration of the Type II Ampakine CX717 Is An Artifact Related to Molecular Structure and ...
Effects of cannabis
March 2015). "How cannabis causes paranoia: using the intravenous administration of ∆9-tetrahydrocannabinol (THC) to identify ... Furthermore, even in those with no family history of psychosis, the administration of pure THC in clinical settings has been ... August 2004). "The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for ... Department of Transportation's National Highway Traffic Safety Administration, it was found that other "studies that measure ...
Physiologically based pharmacokinetic modelling
Intravenous injection is a common clinical route of administration. (to be completed) Inhalation occurs through the lung and is ... these models also facilitate inter-species transpositions or extrapolation from one mode of administration to another (e.g., ... or single to multiple exposures Routes of administration: e.g., from inhalation exposures to ingestion Species: e.g., ...
Voriconazole
... allowing patients to be switched between intravenous and oral administration. Pfizer brought the drug to market as Vfend. A ... It can be taken by mouth or given in a doctor's office or clinic by intravenous infusion. It is toxic to the fetus; pregnant ...
Alpha-1 antitrypsin
These products for intravenous augmentation A1AT therapy can cost up to $100,000 per year per patient. They are administered ... The US Food and Drug Administration (FDA) has approved the use of four alpha-1 antitrypsin products derived from a human plasma ... "Aralast NP". U.S. Food and Drug Administration (FDA). 22 July 2017. Retrieved 11 May 2020. "Aralast". U.S. Food and Drug ... "Prolastin". U.S. Food and Drug Administration (FDA). 5 March 2018. Retrieved 11 May 2020. "Prolastin-C". U.S. Food and Drug ...
Biodyl
Adverse effect Intravenous therapy Electrolyte Oral rehydration therapy Polo pony Endurance riding "BIODYL" (PDF). M.C.I. Santé ... "Refusal Details as Recorded in OASIS by FDA for Refusal 112-4397009-5/1/1/". Food and Drug Administration. Retrieved 2009-06-14 ... U.S. Food and Drug Administration. July 8, 2003. Archived from the original on January 15, 2008. Retrieved April 24, 2009. ... The Associated Press reported erroneously that the Food and Drug Administration had refused to approve the French-made ...
Copanlisib
... at ClinicalTrials.gov Food and Drug Administration. "Drug Trials Snapshots ALIQOPA". www.fda.gov. Food and Drug Administration ... Copanlisib is administered as intravenous infusion on a weekly but intermittent schedule (three weeks on and one week off). ... Food and Drug Administration. "NDA 209936, Approval Letter" (PDF). www.fda.gov. Clinical trial number NCT02728258 for " ... "FDA Prescribing information for Aliqopa" (PDF). Food and Drug Administration. "FDA News Alert: FDA approves new treatment for ...
Pheochromocytoma
... intravenous hydrocortisone in the operating room prior to anesthesia Repeat administration of 25-50 mg intravenous ... Furthermore, the intravenous contrast used in CT can cause kidney damage and should therefore be avoided in patients with pre- ... Some institutions in the United States will even admit patients the night prior to surgery for intravenous fluid replacement ... However, a small trial from 2009 reported no difference in mortality in patients treated with preoperative intravenous fluids ...
Psychotomimetism
2004) found that intravenous THC produced effects that resemble schizophrenia in both the positive symptoms (hallucinations, ... Psychotomimesis is the onset of psychotic symptoms following the administration of such a drug. Some rarely used drugs of the ... "The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis" ( ...
BioCryst Pharmaceuticals
1 clinical safety and pharmacokinetics trials conducted in 2019 by both intravenous and intramuscular routes of administration ...
Dexamethasone suppression test
... with the cortisol level measured 6 hours after the final dose was given Intravenous DST Dexamethasone-CRT test Low-dose and ... A normal result is a decrease in cortisol levels upon administration of low-dose dexamethasone. Results indicative of Cushing's ...
Notes from the Field: Adverse Events Associated with Administration of Simulation Intravenous Fluids to Patients - United...
Notes from the Field: Adverse Events Associated with Administration of Simulation Intravenous Fluids to Patients - United ... A sample of the simulated saline product inadvertently administered to multiple patients as sterile intravenous fluid, with ... Simultaneously, the Food and Drug Administration issued an alert, warning health care professionals not to use any Wallcur ... Both patients experienced a febrile illness during product administration and were hospitalized; one patient developed sepsis ...
Pharmacokinetics and pharmacodynamics of the hydroxymetabolite of glimepiride (Amaryl) after intravenous administration
Octagam intravenous immunoglobulin solutions | Therapeutic Goods Administration (TGA)
Although thromboembolic events are a known rare adverse event associated with the administration of all intravenous ... The Therapeutic Goods Administration (TGA) advises that Octapharma Australia Pty Ltd has agreed to a precautionary voluntary ... and health care providers should report any adverse events that have occurred following administration of Octagam intravenous ... As a result of this decision, all stock of Octagam intravenous immunoglobulin solutions in Australia will be recalled ...
Exposure-Response Analyses of Letermovir Following Oral and Intravenous Administration in Allogeneic Hematopoietic Cell...
Efficacy and Safety of Intracoronary versus Intravenous Administration of Tirofiban during Percutaneous Coronary Intervention...
... tirofiban administration for ACS patients undergoing PCI compared with intravenous (IV) administration. Therefore, this meta- ... IC administration of tirofiban significantly increased TIMI grade 3 flow (OR 2.11; 95% CI 1.02 to 4.37; P = 0.04) and TMP grade ... Conclusions This meta-analysis supports the use of IC over IV administration of tirofiban in patients with ACS to improve TIMI ... Methods We searched PubMed and Medline for randomized controlled trials (RCTs) comparing IC versus IV administration of ...
Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I...
... and efficacy non-inferior to standard intravenous administration, with a similar safety profile to intravenous trastuzumab, and ... Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I- ... Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I- ... Comparison of subcutaneous and intravenous administration of trastuzumab: a phase I/Ib trial in healthy male volunteers and ...
Erowid.org: Erowid Reference 7223 : Gamma-hydroxybutyric acid decreases intravenous cocaine self-administration in rats :...
Fratta W Gamma-hydroxybutyric acid decreases intravenous cocaine self-administration in rats Pharmacol Biochem Behav 1998 59(3 ... "Gamma-hydroxybutyric acid decreases intravenous cocaine self-administration in rats". Pharmacol Biochem Behav. 1998 Mar 05;59(3 ... "Gamma-hydroxybutyric acid decreases intravenous cocaine self-administration in rats" Pharmacol Biochem Behav. 1998 Mar 05;59(3 ... route of administration, and type of operant response required. These results indicate that GHB reduces cocaine-seeking ...
CPT® Code - Injection and Intravenous Infusion Chemotherapy and Other Highly Complex Drug or Highly Complex Biologic Agent...
... code range for Injection and Intravenous Infusion Chemotherapy and Other Highly Complex Drug or Highly Comple ... Injection and Intravenous Infusion Chemotherapy and Other Highly Complex Drug or Highly Complex Biologic Agent Administration ... Injection and Intravenous Infusion Chemotherapy and Other Highly Complex Drug or Highly Complex Biologic Agent Administration ... code range for Chemotherapy Administration and Other Highly Complex Drug or Highly Complex Biologic Agent Administration 96401- ...
Intravenous Steroid Days and Predictors of Early Oral Steroid Administration in Tuberculous Meningitis: A Retrospective Study...
Intravenous (IV) dexamethasone is recommended for 14 days in stage 1 and 28 days in stage 2/3 tuberculous meningitis (TBM). We ... Intravenous Steroid Days and Predictors of Early Oral Steroid Administration in Tuberculous Meningitis: A Retrospective Study ... used intravenous (IV) dexamethasone for 2 weeks, and for stage 2 and 3 TBM, they used IV dexamethasone for 4 weeks. Intravenous ... Corticosteroids (dexamethasone versus intravenous methylprednisolone) in patients with tuberculous meningitis. Ann Trop Med ...
Metabolism and disposition of [14C]dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration,...
... dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration, intravenous administration and dermal ... 2. Disposition of radioactivity was similar between gavage and intravenous administration of 1.5 mg/kg [14C] DMAB, with nearly ... but was higher than following the gavage or intravenous administration. 4. Following co-adminsitration of DMAB and sodium ... Metabolism and disposition of [14C]dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration, ...
Influence of Surgery on the Pharmacokinetics of Tramadol Following Intravenous Administration in Dogs
... ... Influence of Surgery on the Pharmacokinetics of Tramadol Following Intravenous Administration in Dogs. Asian Journal of Animal ... A slightly higher t1/2α (0.32 h) was reported by Kukanich and Papich (2004) following i.v. administration of 4 mg kg-1 tramadol ... Therefore, re-administration of tramadol at 3 h is necessary for pain control. This suggests that surgery has a significant ...
PK/PD profiles of the CXCL8 decoy protein PA401 after intravenous and intratracheal administration in saline and LPS exposed...
PK/PD profiles of the CXCL8 decoy protein PA401 after intravenous and intratracheal administration in saline and LPS exposed ... PK/PD profiles of the CXCL8 decoy protein PA401 after intravenous and intratracheal administration in saline and LPS exposed ... PK/PD profiles of the CXCL8 decoy protein PA401 after intravenous and intratracheal administration in saline and LPS exposed ... PK/PD profiles of the CXCL8 decoy protein PA401 after intravenous and intratracheal administration in saline and LPS exposed ...
Pharmacokinetics of meloxicam following intravenous and oral administration in green iguanas (Iguana iguana) in: American...
... administration. Time from administration to maximum plasma concentration and mean residence time were significantly longer ... Daily administration of high doses (1 or 5 mg/kg) for 12 days did not induce any histologic changes in gastric, hepatic, or ... Conclusions and Clinical Relevance-Results suggested that administration of meloxicam at a dose of 0.2 mg/kg IV or PO in green ... Results-There were no significant differences between PO and IV administration with regard to terminal half-life (mean ± SD, ...
AID 60712 - Inhibitory activity against LTB4 production upon intravenous administration at a dose of 1.0 mg/Kg (0.25-0.5 hour)...
Melanom: A phase I, first in human, two part, open-label clinical trial of intravenous administration of ctl-002 given as...
Intravenous naloxone administration in schizophrenia and affective illness<...
Intravenous naloxone administration in schizophrenia and affective illness. In: Science. 1977 ; Vol. 197, No. 4298. pp. 74-77. ... Intravenous naloxone administration in schizophrenia and affective illness. Glenn C. Davis, William E. Bunney, Emanuel G. ... Intravenous naloxone administration in schizophrenia and affective illness. Science. 1977 Jan 1;197(4298):74-77. doi: 10.1126/ ... Intravenous naloxone administration in schizophrenia and affective illness. / Davis, Glenn C.; Bunney, William E.; Defraites, ...
Intravenous Immunoglobulin: Overview, Uses of Intravenous Immunoglobulin, Pharmacology and Monitoring
Intravenous immunoglobulin (IVIG) contains the pooled immunoglobulin G (IgG) immunoglobulins from the plasma of approximately a ... 3] There are now multiple alternative IVIG preparations available for intravenous administration that have been approved by the ... Which intravenous immunoglobulin (IVIG) preparations are marketed in the US?. How is the liquid intravenous immunoglobulin ( ... What are less common adverse effects of intravenous immunoglobulin (IVIG)?. What is the efficacy of high-dose intravenous ...
Provenge (Sipuleucel-T Suspension for Intravenous Infusion): Uses, Dosage, Side Effects, Interactions, Warning
Sipuleucel-T Suspension for Intravenous Infusion) may treat, side effects, dosage, drug interactions, warnings, patient ... Administration Steps. *Remove the infusion bag from the insulated polyurethane container and inspect the bag for signs of ... For intravenous use only.. Dose. Each dose of PROVENGE contains a minimum of 50 million autologous CD54 cells activated with ... See DOSAGE AND ADMINISTRATION]. Thromboembolic Events. Thromboembolic events, including deep venous thrombosis and pulmonary ...
Effect of perioperative intravenous lidocaine administration on pain, opioid consumption, and quality of life after complex...
Intravenous administration of allogeneic Wharton jelly-derived mesenchymal stem cells for treatment of dogs with congestive...
Intravenous administration of allogeneic Wharton jelly-derived mesenchymal stem cells for treatment of dogs with congestive ... Intravenous administration of allogeneic Wharton jelly-derived mesenchymal stem cells for treatment of dogs with congestive ... Intravenous administration of allogeneic Wharton jelly-derived mesenchymal stem cells for treatment of dogs with congestive ...
A randomised, double-blind, placebo-controlled trial to compare the early administration of intravenous haloperidol versus...
Intravenous Immunoglobulins (IVIGs) - Lupus Erythromatosus A TO Z - Lupus Central Station
Administration: Intravenously. The dose is 400 mg/kg for 5 days. The nurse must work closely with the prescribing physician to ... Intravenous Immunoglobulins (IVIGs). Intravenous Immunoglobulins (IVIGs) may be used to control SLE with organ involvement or ... See Patient Information Sheet on Intravenous Immunoglobulins (IVIGs). Source: National Institutes of Health, U.S.Dept of Health ... https://theodora.com/lupus_central_station/intravenous_immunoglobulins_ivigs.html Copyright © 1995-2021 Photius Coutsoukis (All ...
Safety, Efficacy, and Pharmacokinetic Studies to Support Marketing of Immune Globulin Intravenous (Human) as Replacement...
... and Pharmacokinetic Studies to Support Marketing of Immune Globulin Intravenous (Human) as Replacement Therapy for Primary ... Food and Drug Administration. 5630 Fishers Lane, Rm 1061. Rockville, MD 20852 ... Safety, Efficacy, and Pharmacokinetic Studies to Support Marketing of Immune Globulin Intravenous (Human) as Replacement ... Safety, Efficacy, and Pharmacokinetic Studies to Support Marketing of Immune Globulin Intravenous (Human) as Replacement ...
Cyclosporine metabolism and pharmacokinetics following intravenous and oral administration in the dog - Fingerprint -...
Intravenous Rehydration | Definition and Patient Education
Intravenous (IV) rehydration is a procedure used to treat moderate to severe cases of dehydration. Learn what this procedure ... Intravenous (IV) medications are given into your vein. Learn about the types of IV administration, their uses, and the risks. ... What is intravenous rehydration?. Your doctor, or your childs doctor, may prescribe intravenous (IV) rehydration to treat ... Intravenous hydration. (2012, May 9). shs-manual.ucsc.edu/policy/intravenous-hydration. ...
Doxil (Doxorubicin Liposomal) Intravenous: Uses, Side Effects, Dosage
Doxorubicin liposome is an intravenous chemotherapy used to treat ovarian cancer, AIDS-related Kaposis sarcoma, and multiple ... Following its administration, your urine, tears, and sweat might be reddish-orange. This is a normal effect of the drug and ... Doxil (Doxorubicin Liposomal) - Intravenous Generic Name: doxorubicin liposome (dox-oh-ROO-bi-sin hye-droe-KLOR-ide LYE-poh- ... Doxil (doxorubicin liposome) infusion is an intravenous (IV) chemotherapy medication used to treat different types of cancer, ...
Table 2 - Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl - Volume 15,...
All infections (except in patient 1) developed after administration of intravenous fentanyl compounded at an out-of-state ... Intravenous fentanyl in 0.9% sodium chloride solution from a 250-mL (10 mcg/mL) bag prepared at compounding pharmacy A.. ‡ ... Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl1 Lisa L. Maragakis. , ... Date(s) of fentanyl administration†. Date(s) of infection. Treatment. Outcome. PFGE strain‡. ...
Light-protective Yuria-Pharm system for intravenous administration - YURiA-PHARM
Light-protective Yuria-Pharm system for intravenous administration Yuria-Pharm light protection system has a special design of ... 21G injection needle (0.8 x 38 mm) for intravenous access;. *a patch of 3 tapes to fix the needle and tube system to the ... as well as use the system for the administration of drugs that require protection from the sun; ...
A seven-day study of the pharmacokinetics of intravenous levetiracetam in neonates: marked changes in pharmacokinetics occur...
Piracetam / administration & dosage * Piracetam / analogs & derivatives* * Piracetam / pharmacokinetics * Seizures / drug ... Methods: Eighteen term neonates with seizures persisting after 20 mg/kg of phenobarbital received intravenous LEV for 1 wk. LEV ... A seven-day study of the pharmacokinetics of intravenous levetiracetam in neonates: marked changes in pharmacokinetics occur ...
Antibiotic concentration in human wound fluid after intravenous administration<...
Antibiotic concentration in human wound fluid after intravenous administration. D. H. Bagley, J. Mac Lowry, R. M. Beazley, C. ... Antibiotic concentration in human wound fluid after intravenous administration. / Bagley, D. H.; Mac Lowry, J.; Beazley, R. M. ... Antibiotic concentration in human wound fluid after intravenous administration. In: Unknown Journal. 1978 ; Vol. 188, No. 2. pp ... Antibiotic concentration in human wound fluid after intravenous administration. Unknown Journal. 1978;188(2):202-208. doi: ...
InfusionDoseIntramuscularInjectionsInjectionVersusAssigned to receive intravenousPharmacokinetics of intravenousAvailable for intravenousPatientsRoutesSodium chlorideMesenchymal stemAntibioticsFluidsGammaglobulinFerricPharmacologyMedication administrationRoute of administratRatsAntibioticIVIgPseudomonasSalineImmunoglobulinEfficacyChemotherapyTreatmentClinicalTherapyDosesIntratrachealSyringesVeinDilutionFood and Drug AdminAnesthesiaBenzodiazepinesSepsisPeak plasma concentrationInfectionPhaseTumorHextendDrug AdministrationCardiac
Infusion11
- A subcutaneous formulation of trastuzumab has been developed, offering potential improvements in patient convenience and resource use compared with the standard intravenous infusion of the drug. (thelancet.com)
- Provenge (sipuleucel-T) Suspension for Intravenous Infusion is a prescription medicine used to treat the symptoms of Prostate Cancer. (rxlist.com)
- PROVENGE (sipuleucel-T) is an autologous cellular immunotherapy available as a suspension for intravenous infusion. (rxlist.com)
- Selexipag for intravenous administration, twice daily as an infusion over 87 min. (clinicaltrials.gov)
- After identical single intravenous or intramuscular doses of aztreonam for injection, the serum concentrations of aztreonam are comparable at 1 hour (1.5 hours from start of intravenous infusion) with similar slopes of serum concentrations thereafter. (nih.gov)
- If the method of administration is through continuous infusion, the rate of infusion must be confirmed with another nurse (Joanna Briggs Institute, 2005). (phdessay.com)
- The Phase 1a part of the study is a dose-escalation and dose-optimization phase investigating NG-641 administration by intravenous (IV) infusion in a range of tumour types. (clinicaltrials.gov)
- Aciclovir/Herperax in Kenya is administered by intravenous infusion as the sodium salt over 1 hour. (epharmacyke.com)
- HEXTEND is administered by intravenous infusion only. (pfizermedicalinformation.com)
- The recommended dosing regimen in adult and pediatric patients, one month of age or older weighing 5 kg or greater, with PNH and aHUS consists of a loading dose followed by maintenance dosing, administered by intravenous infusion. (centerwatch.com)
- Adjust vaccinations to accommodate concomitant corticosteroid administration prior to and following onasemnogene abeparvovec infusion. (medscape.com)
Dose18
- In both experiments acute pretreatment with GHB significantly and dose dependently reduced cocaine self-administration. (erowid.org)
- PA401 has been tested in murine models of lung inflammation induced by lipopolysaccharide (LPS) showing strong dose-dependent neutrophil reduction in bronchoalveolar lavage fluid (BALF) after intravenous (IV) and subcutaneous (SC) administration. (ersjournals.com)
- 12) administration of a single dose (0.2 mg/kg). (avma.org)
- The primary objective of this study is to assess whether it is safe for patients with PAH to temporarily change from selexipag tablets (Uptravi®) to selexipag given directly into a vein (intravenous selexipag), and then switching back to the initial oral dose of selexipag. (clinicaltrials.gov)
- For Pseudomonas aeruginosa , a single 2 g intravenous dose produces serum levels that exceed the MIC 90 for approximately 4 to 6 hours. (nih.gov)
- The serum half-life of aztreonam averaged 1.7 hours (1.5 to 2) in subjects with normal renal function, independent of the dose and route of administration. (nih.gov)
- In their regimen, the intravenous dose of atropine was increased stepwise until vomiting was controlled, so the final dose administered varied between patients. (bmj.com)
- An increase in heart rate of about 35 beats/minute (which is usually not noticed by the recipient) within 3-5 minutes of an I.V. dose, and a maximal increase in heart rate of about 35-45 beats/minute with I.M. or autoinjector administration, respectively, within about 35-45 minutes (the longer being with I.M. injection). (cdc.gov)
- The physician reviewed the patient's medication administration record and determined that she received one dose of levofloxacin. (ahrq.gov)
- For herpes simplex infections in the immunocompromised, and for severe initial genital herpes, or varicella-zoster infections in immunocompetent patients, the dose by the intravenous route is 5 mg/kg given every 8 hours, and recommended periods of treatment range from 5 to 7 days. (epharmacyke.com)
- In children, the 8-hourly intravenous dose is best calculated by body-surface using 250 mg/m 2 for herpes simplex and varicella-zoster infections in immunocompetent patients and 500 mg/m 2 for herpes simplex encephalitis and varicella-zoster infection in the immunocompromised. (epharmacyke.com)
- In groups 1 and 2, each bird received a single dose of ART at 2 mg/kg by oral (PO) and intravenous (IV) administrations, respectively. (avensonline.org)
- The recommended dose for acute bovine mastitis is 2.2 mg/kg (1.0 mg/lb: 2 mL per 100 lbs) ofbodyweight given once by intravenous administration. (entirelypetspharmacy.com)
- Starting 2 weeks after the loading dose administration, begin maintenance doses once every 4 or 8 weeks (q4w or q8w), based on body weight. (centerwatch.com)
- to investigate dental patients undergoing sedation using a mean dose of 0.6 mg/kg intravenous midazolam and the adverse events of sedation in patients with ID. (bvsalud.org)
- This study analyzed the records of 163 dental patients with ID aged between 2 and 76 years who had undergone conscious intravenous sedation (CIV) using a mean dose of 0.61 mg/kg of midazolam at Araçatuba Dental School, São Paulo State University, Brazil. (bvsalud.org)
- The recommended dose of t-PA for acute ischemic stroke is 0.9 mg/kg (maximum 90 mg) infused over 60 minutes with 10% of the total dose administered as an initial intravenous bolus over 1 minute (see t-PA dosing chart). (medscape.com)
- 8. Monitor dose administration carefully as total dose is weight-based (0.9 mg/kg or a maximum of 90 mg), so not all the liquid in the vial will be administered. (medscape.com)
Intramuscular5
- Following constitution, the product is for intramuscular or intravenous use. (nih.gov)
- The purpose of this study was to determine intravenous (IV), intramuscular (IM) and oral (PO) FM PK in mature swine. (biomedcentral.com)
- Flunixin-meglumine (FM) is approved in the US as an intramuscular (IM) injection in swine, and is available for intravenous (IV) and oral (PO) administration in other species [ 11 ]. (biomedcentral.com)
- All five trials are assessing intramuscular (IM) administration, with ACTIV-2 evaluating both IM and intravenous administration routes. (cision.com)
- Treatment may be given by intravenous or intramuscular injection and repeatedfor up to five days. (entirelypetspharmacy.com)
Injections1
- Single 3-minute intravenous injections of the same doses resulted in serum levels of 58 mcg/mL, 125 mcg/mL, and 242 mcg/mL at 5 minutes following completion of injection. (nih.gov)
Injection5
- 12 healthy male volunteers received an intravenous injection of hydroxy-gli (1.5 mg) or placebo in a single blind, randomised, cross-over study. (nih.gov)
- This is the number of participants with at least one clinically significant reaction at the injection site (e.g., erythema/redness, tenderness, swelling, induration, hemorrhage at the injection site) occurring on the days of intravenous (iv) selexipag injection. (clinicaltrials.gov)
- Diabetes was induced by the intravenous injection of 60 mg/kg STZ. (elis.sk)
- HEXTEND ® (6% Hetastarch in Lactated Electrolyte Injection) is a sterile, nonpyrogenic solution for intravenous administration. (pfizermedicalinformation.com)
- Ultomiris is supplied as an injection for intravenous administration. (centerwatch.com)
Versus2
- Intravenous versus Non-Intravenous Benzodiazepines for the Abortion of Seizures: A Systematic Review and Meta-analysis of Randomized Controlled Trials. (epmonthly.com)
- There is a lack of evidence to guide emergency physicians regarding selection of patients for oral versus intravenous antibiotic therapy. (medecinedurgence.fr)
Assigned to receive intravenous1
- 299 patients were randomly assigned to receive intravenous trastuzumab and 297 to receive subcutaneous trastuzumab. (thelancet.com)
Pharmacokinetics of intravenous1
- The influence of surgery and anesthesia on the pharmacokinetics of intravenous tramadol in dogs was investigated. (scialert.net)
Available for intravenous1
- [ 3 ] There are now multiple alternative IVIG preparations available for intravenous administration that have been approved by the Food and Drug Administration (FDA) for the treatment of primary humoral immunodeficiencies and chronic immune thrombocytopenic purpura. (medscape.com)
Patients19
- Doctors should cease using Octagam intravenous immunoglobulin solutions immediately, and switch their patients to the most appropriate alternative treatment. (tga.gov.au)
- Patients and health care providers should report any adverse events that have occurred following administration of Octagam intravenous immunoglobulin solution to the TGA via the Adverse Medicine Events Line (1300 134 237), online via ' Report a problem with a medicine ', or using the 'Blue Card' Prepaid Reporting Form . (tga.gov.au)
- On December 23, 2014, the New York State Department of Health (NYSDOH) was notified of adverse health events in two patients who had been inadvertently administered nonsterile, simulation 0.9% sodium chloride intravenous (IV) fluids at an urgent care facility. (cdc.gov)
- NYSDOH issued a state health advisory and posted a report on CDC's Epidemic Information Exchange (Epi-X) to inform public health personnel and medical providers of the potential for inadvertent administration of this product to patients. (cdc.gov)
- Simultaneously, the Food and Drug Administration issued an alert, warning health care professionals not to use any Wallcur simulation IV products in human or animal patients. (cdc.gov)
- Ten health care facilities from nine states might have administered the simulation 0.9% saline product to 45 patients (i.e., simulation saline was either administered or reported to be in the facility at the time of saline administration), although the total number of patients nationwide receiving the simulation product is unknown. (cdc.gov)
- We compared the pharmacokinetic profile, efficacy, and safety of the subcutaneous and intravenous formulations in patients with HER2-positive early breast cancer. (thelancet.com)
- The target population for intravenous selexipag includes those PAH patients who are hospitalized and are unable to swallow tablets of Uptravi. (clinicaltrials.gov)
- Intravenous ferric carboxymaltose is now a potential option for treating patients with iron deficiency anaemia in the community. (bpac.org.nz)
- Intravenous iron is the preferred form of iron supplementation for some patients with co-morbidities such as chronic kidney disease, symptomatic heart failure or inflammatory bowel disease. (bpac.org.nz)
- Intravenous iron supplementation is regarded as the first-line treatment for iron deficiency anaemia in some patients with inflammatory bowel disease, chronic kidney disease or heart failure. (bpac.org.nz)
- these patients have a worse prognosis if they also have iron deficiency, therefore guidelines recommend intravenous iron to alleviate symptoms, improve exercise capacity and quality of life. (bpac.org.nz)
- Intravenous iron treatment is appropriate for patients who initially have severe anaemia as it produces a quicker improvement in the first weeks of treatment than oral iron supplementation. (bpac.org.nz)
- Healthcare providers who see cases of Pseudomonas infection in patients with intravenous catheters are urged to determine if their patients received the recalled heparin/saline flush solution. (cdc.gov)
- Intravenous sedation for dental patients with intellectual disability. (bvsalud.org)
- 10. Fukuta O, Braham RL, Yanase H, Kurosu K. The sedative effects of intranasal midazolam administration in the dental treatment of patients with mental disabilities. (bvsalud.org)
- Within this group, epilepsy is refractory in up to 40 % of patients, who have shown para el control de síntomas refractarios en a decrease in the frequency of seizures with the concomitant use of cannabidiol and conventional antiepileptics, with mild síndromes convulsivos side effects such as diarrhea and drowsiness. (bvsalud.org)
- A comprehensive overview of medical AI devices approved by the US Food and Drug Administration sheds new light on limitations of evaluation that can mask vulnerabilities of devices when they are deployed on patients. (cdc.gov)
- ABSTRACT Objective: To evaluate the effect of training on intravenous medication administration in pediatric patients on nursing staff 's learning and response. (bvsalud.org)
Routes3
- No adverse effects were observed with flunixin meglumine administration for all routes. (biomedcentral.com)
- Do Intravenous First-Line Benzodiazepines Terminate Seizures Faster Than Non-Intravenous Routes? (epmonthly.com)
- Preferred routes of administration of atropine. (cdc.gov)
Sodium chloride1
- Intravenous fentanyl in 0.9% sodium chloride solution from a 250-mL (10 mcg/mL) bag prepared at compounding pharmacy A. ‡Strain A is the outbreak strain that was indistinguishable by PFGE from the fentanyl isolates. (cdc.gov)
Mesenchymal stem2
- Intravenous administration of allogeneic Wharton jelly-derived mesenchymal stem cells for treatment of dogs with congestive heart failure secondary to myxomatous mitral valve disease. (umassmed.edu)
- Classical monocyte-derived macrophages as therapeutic targets of umbilical cord mesenchymal stem cells: comparison of intratracheal and intravenous administration in a mouse model of pulmonary fibrosis. (bvsalud.org)
Antibiotics3
- The patient was intubated, and intravenous antibiotics, norepinephrine, and hydrocortisone were initiated to treat presumed septic shock. (ajmc.com)
- The patient improved with antibiotics and intravenous gammaglobulin therapy. (medscape.com)
- 59 (70.2) had had some experience with intravenous antibiotics administration. (bvsalud.org)
Fluids1
- Photographed inside the Yirgalem prison, located in the Southern Nation and Nationality Peoples Region of Ethiopia, this image was captured during an Ethiopian Field Epidemiology Training Program (FETP) tick-borne relapsing fever (TBRF) outbreak investigation, and depicted a number of prisoners receiving treatment for TBRF, which included the administration of intravenous fluids. (cdc.gov)
Gammaglobulin1
- Also, a liquid, pasteurized, 10% concentrated intravenous gammaglobulin preparation is as effective as a 5% concentrated preparation, making the concentrated versions more convenient to administer. (medscape.com)
Ferric1
- intravenous Ferric carbo Exxon Maltose is indicated for iron deficiency when oral preparations are ineffective or not tolerated. (voices.com)
Pharmacology2
- Teaching correct method of intravenous drug administration and the communication skills about drug therapy in Pharmacology practical classes can help in minimizing the errors in drug administration and improving the patient compliance and adherence to the therapy. (who.int)
- Objectives of this study were teaching module on intravenous drug administration and communication skills to undergraduate students in Pharmacology and to evaluate the perceptions of students and teachers towards the new teaching module.Methods: Correct methods of intravenous drug administration were demonstrated in practical classes. (who.int)
Medication administration1
- Measures included cardiac monitoring, intubation, intravenous line placement, and cardiac resuscitation medication administration. (cdc.gov)
Route of administrat1
- route of administration, and type of operant response required. (erowid.org)
Rats5
- In the present study, two sets of experiments were performed to investigate the effects of acute pretreatment with GHB on intravenous cocaine self-administration in rats. (erowid.org)
- We therefore performed a systematic study to identify the permeation properties of geraniol across intestinal cells, and its pharmacokinetics and bioavailability after intravenous and oral administration to rats. (frontiersin.org)
- After intravenous administration of geraniol to rats (50 mg/kg), its concentration in whole blood (detected via HPLC) decreased following an apparent pseudo-first order kinetics with a half-life of 12.5 ± 1.5 min. (frontiersin.org)
- Following emulsified oral administration, geraniol amounts in the cerebrospinal fluid of rats ranged between 0.72 ± 0.08 μg/mL and 2.6 ± 0.2 μg/mL within 60 min. (frontiersin.org)
- Conjugated or free geraniol metabolites were identified in the urine of rats after oral administration of the monoterpene (800 mg/Kg for 20 days). (frontiersin.org)
Antibiotic1
- Oral antibiotic treatment failure was defined as any of the following after a minimum of 48 hours of oral therapy due to worsening infection: 1) hospitalization, 2) change in class of oral antibiotic, or 3) switch to intravenous therapy. (medecinedurgence.fr)
IVIg3
- The TGA has become aware of reports of a markedly increased incidence of serious adverse reactions associated with Octagam, an intravenous immunoglobulin (IVIg) preparation, manufactured by Octapharma in Europe. (tga.gov.au)
- Intravenous immunoglobulin (IVIG) contains the pooled immunoglobulin G (IgG) immunoglobulins from the plasma of approximately a thousand or more blood donors. (medscape.com)
- One of biggest advances with IVIG in recent years has been the use of sorbitol-based formulations as opposed to sucrose-based formulations which allow for IV administration with less reactions. (medscape.com)
Pseudomonas1
- A large outbreak of Pseudomonas infections was caused by exposure to a contaminated heparin/saline flush syringe that is used in the maintenance of intravenous catheters. (cdc.gov)
Saline2
- it is intended for use by medical trainees practicing IV administration of saline on mannequins or other training devices. (cdc.gov)
- In the present study we have compared PA401 activity after IV and intratracheal (IT) administration in the same model, using saline exposed mice as control. (ersjournals.com)
Immunoglobulin5
- The Therapeutic Goods Administration (TGA) advises that Octapharma Australia Pty Ltd has agreed to a precautionary voluntary recall of all batches of Octagam intravenous immunoglobulin solutions from the Australian market, due to safety concerns regarding an increased incidence of thromboembolic complications associated with the use of this product in Europe and the USA. (tga.gov.au)
- Although thromboembolic events are a known rare adverse event associated with the administration of all intravenous immunoglobulin preparations, as described in the prescribing information for these products, there has recently been a steady accumulation of such events reported following administration of Octagam in Europe and the USA, with a marked increase in incidence noted during the last few months of 2010. (tga.gov.au)
- The TGA has considered the available evidence related to the safety of this product, and with the cooperation of Octapharma Australia Pty Ltd, has agreed that as a precautionary measure, a voluntary recall of all batches of Octagam intravenous immunoglobulin solutions should be instituted in Australia, until the cause of the problem has been identified and appropriate corrective actions have been taken by the manufacturer. (tga.gov.au)
- As a result of this decision, all stock of Octagam intravenous immunoglobulin solutions in Australia will be recalled immediately. (tga.gov.au)
- Adequate supplies of alternative intravenous immunoglobulin solution products are available for clinical use in Australia, and it is not anticipated that this recall will lead to any shortage of supply in the foreseeable future. (tga.gov.au)
Efficacy2
- We, FDA, are providing you, Investigational New Drug Application (IND) sponsors and Biologics License Application (BLA) applicants, recommendations for testing the safety and efficacy of Immune Globulin Intravenous (Human) (IGIV) products as replacement therapy in primary humoral immunodeficiency. (fda.gov)
- To assess the efficacy of a new regimen of intravenous atropine treatment for infantile hypertrophic pyloric stenosis (IHPS) with special reference to regression of pyloric hypertrophy. (bmj.com)
Chemotherapy1
- The Current Procedural Terminology (CPT) code range for Chemotherapy Administration and Other Highly Complex Drug or Highly Complex Biologic Agent Administration 96401-96417 is a medical code set maintained by the American Medical Association. (aapc.com)
Treatment10
- After screening (Visit 1), each subject will participate in the following consecutive treatment periods: Period 1(treatment with oral selexipag at Visit 2/Day 1), Period 2 (treatment with intravenous selexipag at Visit 2/ Day 2 and Day 3), Period 3 (treatment with oral selexipag starting in the evening of Visit 2/Day 3 and ending 7 to 11 days later at Visit 3). (clinicaltrials.gov)
- intravenous iron treatment is preferred as oral iron supplementation does not supply sufficient iron to the bone marrow to support erythropoiesis. (bpac.org.nz)
- Of the 19 infants, 17 (89%) ceased projectile vomiting after treatment with intravenous (median seven days) and subsequent oral (median 44 days) atropine administration. (bmj.com)
- 8, 9 Nagita et al 8 have reported a high success rate using intravenous atropine treatment. (bmj.com)
- If there is no IV access, then non-IV administration, especially IM or IN midazolam is the treatment of choice. (epmonthly.com)
- In the mouse model, the increased number of inflammatory cells in the bronchoalveolar lavage fluid and the degree of lung fibrosis observed in BLM-treated mice were significantly reduced by MSC treatment , which tended to be more prominent with intravenous administration than intratracheal administration . (bvsalud.org)
- However, he developed a hemorrhagic shock due to sudden splenic rupture and continued to deteriorate despite treatment with selective embolization of a branch of the splenic artery, blood transfusion, and administration of norepinephrine and adrenaline. (ajmc.com)
- 11. Averley PA, Girdler NM, Bond S, Steen N, Steele J. A randomised controlled trial of paediatric conscious sedation for dental treatment using intravenous midazolam combined with inhaled nitrous oxide or nitrous oxide/ sevoflurane. (bvsalud.org)
- 13. Chaushu S, Gozal D, Becker A. Intravenous sedation: an adjunct to enable orthodontic treatment for children with disabilities. (bvsalud.org)
- Treatment consists of intravenous administration of 3 mg/kg Ipilimumab, every three weeks. (bvsalud.org)
Clinical1
- 4 Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Health Science Centre, Xi'an Jiaotong University, China. (who.int)
Therapy2
- Therefore, the nasal route for administration of epinephrine appears to be an acceptable alternate method of drug delivery during CPR and compares favorably with standard IV therapy in the canine model. (druglib.com)
- For these reasons, this intravenous anaesthetic is specifically useful for short surgical operations, such as oral surgery, gynaecological investigation, genitourinary procedures, and electroconvulsive therapy. (pharmacy180.com)
Doses1
- 1 to 2 mLper 100 lbs) of bodyweight given by slow intravenous administration either once a day as a single doseor divided into two doses administered at 12 hour intervals for up to 3 days. (entirelypetspharmacy.com)
Intratracheal3
- After establishing a pulmonary fibrosis model via the intratracheal administration of bleomycin (BLM) to 8-week-old mice , MSCs derived from human umbilical cords were administered intravenously or intratracheally on day 10 and the lungs were immunologically analyzed on days 14 and 21. (bvsalud.org)
- Among M2 MoMs, M2 MoMs derived from Ly6C+ monocytes were most effectively regulated by the intravenous administration , not intratracheal administration , of MSCs. (bvsalud.org)
- Intravenous rather than intratracheal administration of MSCs may ameliorate pulmonary fibrosis by inhibiting monocyte differentiation into M2 macrophages . (bvsalud.org)
Syringes1
- Reportedly, the prepared syringes were not tested for the presence of bacteria as recommended by the Good Manufacturing Practices established by the Food and Drug Administration (FDA). (cdc.gov)
Vein1
- Intravenous - or within the vein - is a term commonly used in medicine. (completeanatomy.cn)
Dilution1
- The molecule consists of an iron hydroxide core collated in a carbohydrate shell after the dilution and intravenous administration. (voices.com)
Food and Drug Admin6
- Healthcare providers may prescribe Doxil for off-label uses, meaning for conditions not specifically indicated by the Food and Drug Administration (FDA). (verywellhealth.com)
- In 2014, the U.S. Food and Drug Administration (FDA) approved the use of a medicine called naloxone (brand name Narcan) to reverse the effects of a heroin overdose. (medlineplus.gov)
- The value of the extended agreement is $205m and is contingent on AZD7442 receiving Food and Drug Administration Emergency Use Authorisation in post-exposure prophylaxis - the ability to prevent COVID-19 in people who have confirmed exposure to the SARS-CoV-2 virus. (cision.com)
- To help practitioners weigh the risks and benefits of drug exposure during pregnancy, the United States Food and Drug Administration (FDA) in 1979 devised a categorization scheme to communicate the safety of medications in pregnancy in terms of effects on the fetus ( Table ). (ahrq.gov)
- If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly by visiting www.fda.gov/medwatch or by calling (800)-332-1088 . (pfizermedicalinformation.com)
- There are no Food and Drug Administration (FDA)-approved treatments for monkeypox. (cdc.gov)
Anesthesia2
- The current study compared the long-term biochemical recurrence of prostate cancer after robot-assisted laparoscopic radical prostatectomy (RALP) in terms of selection of anesthetic agent between total intravenous anesthesia (TIVA) with propofol/remifentanil and volatile anesthetics (VA) with sevoflurane or desflurane/remifentanil. (medsci.org)
- Propofol has been reported to exhibit positive immunomodulatory effects [ 3 - 5 ], and better survival has been reported after cancer surgery with propofol-based total intravenous anesthesia (TIVA) compared to volatile anesthesia (VA) [ 6 - 9 ]. (medsci.org)
Benzodiazepines1
- While the intravenous (IV) delivery of benzodiazepines (BZD) is the most direct and reliable route, non-IV administration of BZDs may be more effective due to more rapid administration. (epmonthly.com)
Sepsis1
- Held MR , Begier EM , Beardsley DS , Browne FA , Martinello RA , Baltimore RS , Life-threatening sepsis caused by Burkholderia cepacia from contaminated intravenous flush solutions prepared by a compounding pharmacy in another state. (cdc.gov)
Peak plasma concentration2
- A mean peak plasma concentration (C MAX ) for IM and PO administration was 3748 ng/ml (range: 2749-6004 ng/ml) and 946 ng/ml (range: 554-1593 ng/ml), respectively. (biomedcentral.com)
- TA reaches peak plasma concentration immediately after intravenous administration A meta-analysis evaluated the use of tranexamic acid after vaginal delivery for prevention of primary PPH. (centerwatch.com)
Infection1
- Sunenshine RH , Tan ET , Terashita DM , Jensen BJ , Kacica MA , Sickbert-Bennett EE , A multistate outbreak of Serratia marcescens bloodstream infection associated with contaminated intravenous magnesium sulfate from a compounding pharmacy. (cdc.gov)
Phase2
Tumor2
- Intravenous administration of PMB-DHMEQ reduced the tumor volume and liver metastasis compared to untreated or CMC-DHMEQ-treated mice. (elsevier.com)
- El Ipilimumab es un anticuerpo humano monoclonal que interferiría en la interacción entre CTLA-4 y su ligando (B7) en la célula presentadora de antígeno, causando un bloqueo de su función inmunomoduladora, aumentando el número y la actividad de linfocitos T quienes atacarían el tumor. (bvsalud.org)
Hextend2
- To determine if there were significant differences between the tibial intraosseous (TIO) and intravenous (IV) administration of Hextend relative to time and in hemodynamics in a hypovolemic model. (wmpllc.org)
- Based upon the findings of this study, the TIO route might be considered the first choice for rapid vascular access and the administration of Hextend. (wmpllc.org)
Drug Administration3
- Application of aseptic technique is essential in the process of drug administration through the intravenous route. (phdessay.com)
- After drug administration, the patient must now be watched closely for adverse reaction to the drug. (phdessay.com)
- Therefore, the objective of this study was to determine if intranasal administration of epinephrine during CPR would provide an alternate route of drug administration that is readily accessible and requires no special technical skills. (druglib.com)
Cardiac1
- Effects of intraosseous tibial vs. intravenous vasopressin in a hypovolemic cardiac arrest model. (wmpllc.org)