The giving of drugs, chemicals, or other substances by mouth.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Injections made into a vein for therapeutic or experimental purposes.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Elements of limited time intervals, contributing to particular results or situations.
Delivery of medications through the nasal mucosa.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Delivery of substances through VENIPUNCTURE into the VEINS.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Injections into the cerebral ventricles.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
The application of suitable drug dosage forms to the skin for either local or systemic effects.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Administration of a soluble dosage form by placement under the tongue.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
The observable response an animal makes to any situation.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
Proteins prepared by recombinant DNA technology.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Introduction of substances into the body using a needle and syringe.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Introduction of therapeutic agents into the spinal region using a needle and syringe.
The measurement of an organ in volume, mass, or heaviness.
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Administration of a drug or chemical by the individual under the direction of a physician. It includes administration clinically or experimentally, by human or animal.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
The physical activity of a human or an animal as a behavioral phenomenon.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Compounds capable of relieving pain without the loss of CONSCIOUSNESS.
Therapy with two or more separate preparations given for a combined effect.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Delivery of drugs into an artery.
Administration of a soluble dosage form between the cheek and gingiva. It may involve direct application of a drug onto the buccal mucosa, as by painting or spraying.
An encapsulated lymphatic organ through which venous blood filters.
A family of hexahydropyridines.
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
Antibodies produced by a single clone of cells.
Uptake of substances through the lining of the INTESTINES.
Glucose in blood.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
The action of a drug in promoting or enhancing the effectiveness of another drug.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
The consumption of edible substances.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Substances that reduce or suppress INFLAMMATION.
Substances that reduce the growth or reproduction of BACTERIA.
A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.
An anti-inflammatory 9-fluoro-glucocorticoid.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
The insertion of drugs into the vagina to treat local infections, neoplasms, or to induce labor. The dosage forms may include medicated pessaries, irrigation fluids, and suppositories.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Refers to animals in the period of time just after birth.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
The measure of the level of heat of a human or animal.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Agents inhibiting the effect of narcotics on the central nervous system.
The rate dynamics in chemical or physical systems.
An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.
A cabinet department in the Executive Branch of the United States Government concerned with overall planning, promoting, and administering programs pertaining to VETERANS. It was established March 15, 1989 as a Cabinet-level position.
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
Use of plants or herbs to treat diseases or to alleviate pain.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
Drugs used to cause dilation of the blood vessels.
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.
Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
The flow of BLOOD through or around an organ or region of the body.
A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
The surgical removal of one or both ovaries.
An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Implanted fluid propulsion systems with self-contained power source for providing long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristatically controlled with the aid of transcutaneous monitoring.
A gonadotropic glycoprotein hormone produced primarily by the PLACENTA. Similar to the pituitary LUTEINIZING HORMONE in structure and function, chorionic gonadotropin is involved in maintaining the CORPUS LUTEUM during pregnancy. CG consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is virtually identical to the alpha subunits of the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN).
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.
Disease having a short and relatively severe course.
Substances which lower blood glucose levels.
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
A group of compounds that contain the structure SO2NH2.
A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.

Homing of stem cells to sites of inflammatory brain injury after intracerebral and intravenous administration: a longitudinal imaging study. (1/222)

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Intravenous therapies for castration-resistant prostate cancer: toxicities and adverse events. (2/222)

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Population pharmacokinetic and pharmacodynamic model-based comparability assessment of a recombinant human Epoetin Alfa and the Biosimilar HX575. (3/222)

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Variability in the use of intravenous thrombolysis for mild stroke: experience across the SPOTRIAS network. (4/222)

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Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine. (5/222)

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A novel vitamin K1 2,3-epoxide reductase (VKOR) inhibitor, 3-acetyl-5-methyltetronic acid, reduces experimental glomerulonephritis. (6/222)

Excessive proliferation of mesangial cells is observed in various types of glomerular disease including glomerulonephritis (GN), which is progressive in nature and eventually results in end-stage renal disease (ESRD). Vitamin K(1) 2,3-epoxide reductase (VKOR) and the vitamin K-dependent growth arrest-specific gene 6/Axl pathway play a key role in mesangial cell proliferation in GN. In the present study, we indicate the potential of a VKOR inhibitor, 3-acetyl-5-methyltetronic acid (AMT), to prevent the proliferation of glomerular mesangial cells and suppress the progression of GN. AMT was administered intravenously to rats once daily for 12 days and a mouse anti-Thy1 monoclonal antibody was injected intravenously after the AMT treatment on Day 6. Creatinine clearance (CCr) significantly increased and the albumin-to-creatinine ratio (ACR) significantly decreased in the AMT-treated group of the Thy-1 GN rats. In addition, glomerular and tubular damage was improved histopathologically in the AMT-treated group. AMT did not affect blood coagulation due to its unique pharmacokinetic properties. The concentration of AMT reached the IC(50) for VKOR in kidney, but not in liver. A novel VKOR inhibitor, AMT, reduced renal mesangial cell proliferation and could be a supportive treatment for GN.  (+info)

Population pharmacokinetic model of canrenone after intravenous administration of potassium canrenoate to paediatric patients. (7/222)

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Paricalcitol versus cinacalcet plus low-dose vitamin D therapy for the treatment of secondary hyperparathyroidism in patients receiving haemodialysis: results of the IMPACT SHPT study. (8/222)

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Prime Minister Ariel Sharon of Israel suffered a mild stroke and was hospitalized, but within hours he was recovering and in good condition, spokesmen for the hospital and Mr. Sharons office said. |p| The episode raised questions about whether Mr. Sharon, 77, would be able to continue in his post and whether he would be able to seek a third term as prime minister. |p| Article, Page A18. |p|
PRISMS is a double-blind, multicenter, randomized, Phase IIIb study to evaluate the efficacy and safety of intravenous (IV) alteplase in participants with mild
I believe the latter is more likely, as T-waves like this are most commonly seen in CNS catastrophes. A mild stroke is normally not enough to cause this (it is not enough of a CNS catastrophe), but I think this goes to show how intimate the connection between the brain and the heart can be ...
DWI-ASPECTS ≥7 was an independent predictor of short-term neurological recovery after an M1-MCAO. Limited DWI changes before IV-tPA have been reported as a predictor of neurological recovery.4 Presence of a clinical-DWI mismatch defined as DWI-ASPECTS ≥7 and an NIHSS score ≥8 has also been reported to be predictors of neurological recovery after IV-tPA.5 An advantage of our study is that the utility of DWI-ASPECTS was evaluated after adjusting for several established imaging and laboratory parameters.. Although early recanalization was associated with DR in patients with DWI-ASPECTS ≥7 and ,7, its role regarding clinical and radiological outcomes depended on the initial DWI-ASPECTS. In patients with DWI-ASPECTS ≥7, the favorable outcome rate and follow-up infarct volume were not statistically different between patients with and without early recanalization. To the contrary, in patients with DWI-ASPECTS ,7, favorable outcomes were only seen in patients with early recanalization. Early ...
This multicenter, randomized, double-blind, parallel-group, placebo-controlled study will evaluate the efficacy and safety of bitopertin in combination with SSRI in participants with obsessive-compulsive disorder. Participants will be randomized to receive either bitopertin 30 milligrams (mg) or bitopertin 10 mg or placebo orally daily in addition to their background therapy with an SSRI. Participants will be allocated to one of two strata. Participants in Stratum 1 will start study drug on Day 1. Participants in Stratum 2 will receive placebo from Day 1 (placebo lead-in) and will then start study drug at the Week 2 visit. Participants in both strata will receive the study drug in addition to their background therapy with an SSRI until Week 16 ...
Family Radio Network preacher Harold Camping, known for his failed rapture prediction, will be released from an Oakland, Calif.-area hospital where he was treated for a mild stroke, Family Radio employees said Monday.
Health,Intravenous delivery of an approved clot-busting drug remains the most... The Guidelines for the Early Management of Adults with Ischemic S... The guidelines focus on the crucial first hours from the time an ... The panel emphasized the importance of public education on the sy... ? Sudden numbness or weakness of the face arm or leg especially...,Intravenous,Delivery,of,Clot-busting,Drug,Still,Best,Intervention,for,Ischemic,Stroke,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
iframe width=640 height=360 src=http://cbn.com/tv/embedplayer.aspx?bcid=1384141689001 frameborder=0 allowfullscreen,,/iframe ...
The B Braun Rate Flow Regulator IV Set carefully regulates the flow of medication or fluids to the patient through an IV.There are two IV administration set options with varying drip rates The B Braun V5922 IV Administration Set with Rate Flow Regulator has a drip rate of 20 drops/mL and the B Braun V5926 Mini Drop IV Administration Set with Rate Flow regulator has 60 drops/mL. ...
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A mild stroke in middle age, such as the one suffered by Beau Biden, isn't uncommon, doctors say. And the cause could be a number of things.
The story so far (5/29/2011) All, I had a little mishap this week. Now that the immediate crisis has passed, I wanted to get my version of events out so that the rumors and cheap, sleazy innuendo can all start from the same basis. Thursday morning I had what doctors are calling a mild stroke.…
Find information on Peginesatide (Omontys) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
Definition of paracervical block in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is paracervical block? Meaning of paracervical block as a finance term. What does paracervical block mean in finance?
As discussed above, no satisfying therapeutic options exist for treatment of locally advanced and metastatic pancreatic cancer. The prognosis is dismal with a six-month progression-free survival of approximately 50% and a median survival of about 11 months [5].. The first open, non-randomized clinical trial with ParvOryx, referred to as ParvOryx01, evaluated safety and tolerability as well as antitumor activity and clinical efficacy in patients with progressive primary or recurrent glioblastoma multiforme (GBM). ParvOryx01 was completed in May 2015 [18]. The investigated doses ranged between 1E06 and 5E09 pfu. They were administered as combination of either multiple intravenous infusions or a single intratumoral injection and multifocal intracerebral injections at the end of tumor resection surgery. As in the current trial, the intravenous dose was divided into equal fractions which were given on consecutive days. The interval between the first administration and surgery with subsequent ...
As discussed above, no satisfying therapeutic options exist for treatment of locally advanced and metastatic pancreatic cancer. The prognosis is dismal with a six-month progression-free survival of approximately 50% and a median survival of about 11 months [5].. The first open, non-randomized clinical trial with ParvOryx, referred to as ParvOryx01, evaluated safety and tolerability as well as antitumor activity and clinical efficacy in patients with progressive primary or recurrent glioblastoma multiforme (GBM). ParvOryx01 was completed in May 2015 [18]. The investigated doses ranged between 1E06 and 5E09 pfu. They were administered as combination of either multiple intravenous infusions or a single intratumoral injection and multifocal intracerebral injections at the end of tumor resection surgery. As in the current trial, the intravenous dose was divided into equal fractions which were given on consecutive days. The interval between the first administration and surgery with subsequent ...
Every year, thousands of people in Canada either die or are permanently disabled after suffering a stroke. This costs our society billions of dollars in physician services, hospital expenses, and decreased productivity. Some individuals are slightly more lucky; instead of having a severe stroke, they have either a very mild stroke or temporary stroke symptoms, also known as a transient ischemic attack (TIA), and do not experience any loss of abilities. However, mild strokes and TIAs can precede the onset of a more serious, disabling stroke. Most of the significant strokes that happen after a mild stroke or TIA occur within days of the original event; there is a need for early interventions that could prevent such occurrences.. One of the goals of recent research has been to find ways to prevent major strokes after individuals have sustained a minor stroke or TIA. Up until now, stroke doctors have focused on treating elevated blood pressures and cholesterol levels, scanning the blood vessels in ...
The consequences of the trials were promulgated in a scrap in Biological Psychiatry by Dr. Dragana Bugarski-Kirola of Roche Pharmaceuticals in Basal, Switzerland. The randomized, double-blind, parallel-group, placebo-controlled libraries were a collaboration between Roche and detached research installations about the the human scramble.. We are backside to the sketch embark on, undignified Dr. John Krystal, Redactor of Biological Psychiatry.. Above-mentioned undertakings to analyse pessimistic earmarks compel ought to hired dopes, hormones, and brains stimulation, but no one bring into the world contributed the desired clinical edge. Research engineer glutamate signaling in denying symptoms has itchy the idea of end glutamate receptors, but this method has peter out in muscular pests. Glycine reuptake inhibitors upkeep been cogitate oned a encouraging alterative to augment glutamatergic signaling, and a humiliated proof-of-concept test showed that bitopertin, which selectively put an ends ...
Qiao, J, Wang, H, Kottke, T, White, C, Twigger, K, Diaz, RM, Thompson, J, Selby, P, de Bono, J, Melcher, A et al, Pandha, H, Coffey, M, Vile, R and Harrington, K. (2008) Cyclophosphamide facilitates antitumor efficacy against subcutaneous tumors following intravenous delivery of reovirus ...
SAN FRANCISCO, July 25, 2012- Jennerex Announces First Patient Treated in Phase 2 Clinical Trial of Intravenous Delivery JX-594 In Patients with Advanced Liver Cancer.
Dr. Edsall responded: Numbing the nerves. The doctor puts his fingers in the vagina and guides the needle beside the |a href=/topics/cervix track_data={
A study found that the drug ticagrelor (Brilinta) was no better than aspirin at preventing stroke among people who had a mild stroke or a transient ischemic…
Id like to nominate my family for your deserving family photo session. On Nov 13th Of this year (yes, just over a month ago) I brought my Mom to the hospital because I suspected she was having a mild stroke. At exactly 4pm that day, they told us she had a massive brain tumor...and our lives changed forever. My Mom, just 63, has always been vibrant, active, independent, and the life of the party. Since her diagnosis and subsequent craniotomy two days later, she has become flat, dependant and Someone so unlike the Mom I know. She has been living in my home since being released from the hospital. We go to Hartford everyday for radiation treatments and she takes chemo pills every night. But the tumor progresses and her memory and abilities have become limited -- even in such a very short time. After being told she had a prognosis of 12 months when she was first diagnosed, the oncologists now tell me she is more likely to pass within 3 to 6 months. This all happened so suddenly. ...
Id like to nominate my family for your deserving family photo session. On Nov 13th Of this year (yes, just over a month ago) I brought my Mom to the hospital because I suspected she was having a mild stroke. At exactly 4pm that day, they told us she had a massive brain tumor...and our lives changed forever. My Mom, just 63, has always been vibrant, active, independent, and the life of the party. Since her diagnosis and subsequent craniotomy two days later, she has become flat, dependant and Someone so unlike the Mom I know. She has been living in my home since being released from the hospital. We go to Hartford everyday for radiation treatments and she takes chemo pills every night. But the tumor progresses and her memory and abilities have become limited -- even in such a very short time. After being told she had a prognosis of 12 months when she was first diagnosed, the oncologists now tell me she is more likely to pass within 3 to 6 months. This all happened so suddenly. ...
Cyto-Set Safer cytostatic preparation and application IV Administration Always a closed system Protect yourself and your environment The number of cytostatic infusions that have to be prepared is growing
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The expected shelf life of Brackett elements stored in their original packaging and out of direct sunlight is as follows: 4 years from date of manufacture
Intravenous administration of nutrients can achieve serum concentrations not obtainable with oral, or even intramuscular (IM), administration.
Intrathecal Labor Analgesia, Paracervical Block, Transcutaneous Electrical erve Stimulation (TENS), lok saraf perineal dan pudendal merupakan metode atau cara menghilangkan Rasa Sakit Persalinan secara Medis. Berikut penjelasannya: Intrathecal Labor Analgesia (ILA). Teknik ILA dilakukan dengan cara menyuntikkan obat penghilang rasa sakit kepada ibu yang akan bersalin normal. Obat ini disuntikkan di daerah urat saraf, yaitu pada tulang belakang bagian bawah. Teknik ILA membebaskan ibu dari rasa nyeri persalinan sekitar 12 jam. Paracervical Block. Paracervical block juga tergolong pembiusan. Metode ini digunakan untuk menghilangkan rasa sakit pada persalinan tahap pertama. Anestesi diberikan melalui suntikan di sisi leher rahim sehingga menghambat rasa sakit. Paracervical block berisiko menghambat detak jantung bayi sehingga dikhawatirkan membahayakan bayi.. Blok saraf perineal dan pudendal. Blok saraf pudendal merupakan suntikan untuk mengebalkan saraf yang mengirim informasi sakit ke area ...
Manuka honey genital herpes is a kind of disease relieve of herpes. of this honey twice a day when I was first healing my stomach lining. Manuka honey is the best quality of honey available. Manuka Honey & Herpes What is Manuka Honey? Honey in itself has been a long-time, natural medicine for healing many wounds caused by bacteria and inflammation. Whether it truly works or not is unknown, though researchers out of Germany have found that Manuka essential oil…. Activon Tube contains 100% Manuka honey with no additives from New Zealand. Really tempted to buy beck pulser & lauricidin, rife machine is too expensive. Manuka Honey Acne How To Vitamin For Acid Gel Scars Page 4 of 5. Another antibacterial component in Manuka honey is methylglyoxal (MG). What is UMF 16+, MGO 400+, Active? Deciphering manuka honey: UMF15+, MGO400, 24+ Bio Active, KFactor16, TA. It was even discovered in the tomb of King Tut. See more ideas about Health remedies, Natural cures, Health. Clinical trials have found that ...
This is a special type of honey extracted only from New Zealand. Manuka honey, a highly medicinal honey found only in the tiny nation, has captured the attention of doctors, researchers and health freaks everywhere. Some people are now even starting to make home-made mixtures with raw honey. You will chose right product because my site use AI Technology and Big Data to filter milions products. Most eye patients treated in the. Manuka Oil is believed to be beneficial for foot and body odor. Made with our high grade MGO400+ Manuka Honey, certified for natural methylglyoxal content (400mg/kg). For medical purposes raw honey should be used. We are acquainted with many foods where honey is an. Manuka honey proved to be more efficient than single antibiotics against biofilms of Pseudomonas aeruginosa and Staphylococcus aureus. The best type of honey for treating eye infections is Manuka honey. As Manuka honey has various benefits, how to make Manuka honey eye drops gain popularity as it is claimed to ...
Description. Comvita Bio Active 10+ Manuka Honey contains a high level of antibacterial activity not found in other honeys. For digestive health and to assist the digestive process. Every batch of Comvita Bio Active 10+ Manuka Honey is tested by an independent laboratory for UMF antibacterial activity, using a testing methods developed at Waikato University. Each jar is guaranteed to have an antibacterial activity 2,5 times greater than standard antiseptic (minimum 10% cabolic equivalent). Comvita Bio Active 10+ Manuka Honey is packaged in an un-breakable, brown-tinted container, designed to protect important natural components present in the honey from destruction by light. Comvita Bio Active 10+ Manuka Honey, is pure, raw, natural honey with all the natural enzymes and pollen intact. Comvita Bio Active 10+ Manuka Honey has a very long shelf life with excellent preservation of its health-giving qualities. One Doctor likes to tell the story of the 20-year-old wound. Infected with ...
2 Answers (question resolved) - Posted in: headache, ischemic stroke, warfarin - Answer: Hi, headache and unexplained swelling are both possible side ...
Manuka honey for wounds of all kinds is used as a natural ointment. In an age of resistance to conventional antibiotics, it has been hailed as a go-to germ fighter. Proponents also claim that Manuka honey can treat problems from acne to sinus problems with other conditions. Manuka honey has not been used as a tradition
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Manuka Honey from Comvita is authentic New Zealand sourced UMF(TM)-graded Manuka Honey. which independentyl verified using the UMF(TM) trade mark, for its unique properties. UMF™ trade mark is an assurance that you are buying premium quality, unadulterated Manuka Honey, with unique properties remaining true to the source from hive to shelf.
Buy online and learn more about Active Manuka Honey UMF®16+ 3 Month Supply from Manuka Honey USA, the original Manuka honey company in the United States.
Manuka honey from New Zealand has potent antibacterial properties that can help treat cuts, improve skin, and bolster gut health. Here, the manuka benefits you should know, how to use it, and where to buy it.
For many years Manuka Honey has been known for its antibacterial properties, but its properties have never been studied for cancer research. Until now, UAE University conducted an over five year study where they researched the effects of cancer cells when they were tested with Manuka Honey. A UAE University official said, Though the honey,…
Introduction In this article I will be telling you about the Stores that carry active Manuka honey. As you know that buying Manuka honey is extremely hard as it is very difficult to find a place to purchase the honey from also sometimes people get mistaken by how...
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Wild Cape Manuka Honey 250g, High UMF factor. Its antiviral, antiseptic, antifungal, and antibacterial action is useful for making medicines. Visit our Healthyworld online store & browse through Manuka Honey Free Shipping, CoD. Order Now!
There have been several examinations in the USA and we are also observing it with concern in European countries such as Italy, Spain and Germany: Significantly fewer patients with minor strokes come to the clinics and are there on stroke units - departments specializing in stroke patients in the hospital - treat. We fear that this will have an indirect impact of the pandemic because people are afraid of getting infected in the hospital and therefore do not take stroke warning symptoms as seriously as they should. Every second stroke there are volatile symptoms, also known as transient ischemic attack (TIA) or mild stroke. And these precede severe strokes. At the moment we cannot really assess the impact of the pandemic, but we fear that severe strokes will end up being more common than before. And not just because of the virus, but mainly because those affected do not go to the clinic if there are warning signs.. The Transient ischemic attack - in short TIA - is considered a harbinger of a ...
French screen icon Catherine Deneuve is feeling fine but still recuperating in a Paris hospital from a mild stroke, her publicist said.
I am a 38 year old female who suffered a mild stroke 3 weeks ago. I was approx 12 weeks pregnant at the time. I have not used birth control pills for almost 10 years. The doctors say it was a blod clo...
Transient ischemic attack (TIA) is a mild stroke caused by a brief interruption of blood flow to the brain. It causes stroke-like symptoms, such as...
Learn about the potential health benefits and uses of Manuka Honey including dosage, side effects, drug interactions and safety profile.
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Manuka honey is one of the best remedies for herpes. Its antibiotic and antiviral properties help in killing the virus and reduces the further outbreaks.
Dolphen, R. ; Lesne, Michel. Cardiac-glycosides and Their Metabolites Levels in Plasma and Heart of Guinea-pigs After Iv Administration. In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 251, no. 1, p. 4-25 (1981 ...
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Intravenous administration of STAg causes production of IL-12 p40 that can prime an IFN-γ response. (A) Spontaneous IL-12 production by spleen cells isolated
The device can reliably detect 4cc leakage, increases nursing productivity and works with both forearm and back of the hand that are IV administration sites.
1H2A: Unusual ligand structure in Ni-Fe active center and an additional Mg site in hydrogenase revealed by high resolution X-ray structure analysis.
Intravenous vs oral administration[edit]. Vancomycin must be given intravenously (IV) for systemic therapy, since it is not ... the pills are more expensive than the intravenous solution.[3] The intravenous solution may be safely taken by mouth for the ... Following oral administration, the fecal concentration of vancomycin is around 500 µg/ml[28] (sensitive strains of C. difficile ... Vancomycin is available as a generic medication.[5] The wholesale cost of an intravenous dose is about US$1.70 to 6.00.[10] In ...
Intravenous[edit]. A patient-controlled analgesia infusion pump, configured for intravenous administration of morphine for ... Routes of administration[edit]. Oral[edit]. The most common form of patient-controlled analgesia is self-administration of oral ... In a hospital setting, a PCA refers to an electronically controlled infusion pump that delivers an amount of intravenous ... These are popular for administration of opioids such as fentanyl, or local anesthetics such as lidocaine. Iontocaine is one ...
... prolonged intravenous administration is associated with lower mortality than bolus intravenous infusion in persons with whose ... Administration[edit]. Meropenem is administered intravenously as a white crystalline powder to be dissolved in 5% monobasic ... Vardakas KZ, Voulgaris GL, Maliaros A, Samonis G, Falagas ME (January 2018). "Prolonged versus short-term intravenous infusion ...
Analysis of 872 patients with 978 florbetaben administrations found no serious adverse reactions related to the tracer.[1] All ... Intravenous injections of florbetaben are generally well tolerated in all subject groups. ...
Administration a 100 mg/m2 dose over a one-hour infusion gave a mean total body clearance of 21 L/h/m2 and a mean steady state ... The one-vial formulation is administered as an aqueous intravenous solution that contains the same drug substance in the same ... While a 2010 article in Current Clinical Pharmacology states, "weekly administration has emerged as the optimal schedule," the ... Premedication with corticosteroids is recommended before each administration of docetaxel to reduce fluid retention and ...
administration. Intravenous. ATC code. *J01DI54 (WHO) (combination with β-lactamase inhibitor). Legal status. ...
The European Commission and the U.S. Food and Drug Administration (FDA) have granted orphan drug status to trabectedin for soft ... administration. Intravenous. ATC code. *L01CX01 (WHO). Legal status. Legal status. *UK: POM (Prescription only) ...
Folotyn was approved by the U.S. Food and Drug Administration (FDA) in September 2009 under the FDA's accelerated approval,[2] ... administration. Intravenous. ATC code. *L01BA05 (WHO) Legal status. Legal status. *US: ℞-only ...
administration. intravenous. ATCvet code. *QJ01XX95 (WHO) Pharmacokinetic data. Bioavailability. negligible oral ...
Food and Drug Administration. 2006-02-21. Archived from the original on 10 July 2009. Retrieved 2009-08-01.. ... "Eraxis (anidulafungin) for Injection, for Intravenous Use. Full Prescribing Information". Roerig (Division of Pfizer, Inc.), ... Trissel LA and Ogundele AB, "Compatibility of Anidulafungin With Other Drugs During Simulated Y-Site Administration,"Am J ... Pfizer gained approval by the Food and Drug Administration (FDA) on February 21, 2006.[17] ...
administration. Intravenous. ATC code. *J01DI54 (WHO) (combination with β-lactamase inhibitor). Legal status. ... Miller B, Hershberger E, Benziger D, Trinh M, Friedland I (June 2012). "Pharmacokinetics and safety of intravenous ceftolozane- ... no significant drug-drug or food-drug interactions have been associated with ceftolozane/tazobactam administration. However, ...
"Vyeptitm (eptinezumab-jjmr) injection, for intravenous use" (PDF). U.S. Food and Drug Administration (FDA). Retrieved 24 ... "U.S. Food and Drug Administration (FDA). Retrieved 24 February 2020.. *^ a b c d e f g h i "Drug Trials Snapshots: VYEPTI". U.S ... Food and Drug Administration (FDA). 21 February 2020. Retrieved 17 March 2020.. This article incorporates text from this source ... The U.S. Food and Drug Administration (FDA) approved eptinezumab based primarily on evidence from two clinical trials (Trial 1 ...
"U.S. Food and Drug Administration.. *^ a b c Lanigan, R. S.; Yamarik, T. A. (2002). "Final report on the safety assessment of ... US Food and Drug Administration: Center for Food Safety and Applied Nutrition Questions and Answers on the Occurrence of ...
It gained European approval in 1996 (initially in France) and approval by the U.S. Food and Drug Administration in 2002. ... administration. Intravenous. ATC code. *L01XA03 (WHO) Legal status. Legal status. *US: ℞-only ...
administration. Intravenous. ATC code. *M03AC09 (WHO) Legal status. Legal status. *UK: POM (Prescription only) ...
Recreational use of the drug via self-administration has been reported[25][26] but is relatively rare due to its potency and ... A more serious but rare side effect is dystonia.[52] Mild myoclonic movements are common, as with other intravenous hypnotic ... The US Food and Drug Administration approved the product in 2008.[74] However fospropofol is a Schedule IV controlled substance ... However, the first execution by the administration of a lethal dose of propofol was halted on October 11, 2013, by governor Jay ...
administration. Intravenous infusion. ATC code. *none. Legal status. Legal status. *US: ℞-only ...
administration. intravenous, topical. ATC code. *B05BB01 (WHO) Ringer's lactate solution (RL), also known as sodium lactate ... For fluid resuscitation the usual rate of administration is 20 to 30 ml/kg body weight/hour. RL is not suitable for maintenance ... Careful monitoring of blood acid-base balance is essential during the administration of sodium lactate.. ... aggressive administration of sodium lactate may result in metabolic alkalosis. ...
administration. Oral, intravenous. ATC code. *N05AC03 (WHO) Legal status. Legal status. *In general: ℞ (Prescription only) ...
... has been approved by the U.S Food and Drug Administration on June 20, 2014, for the treatment of acute bacterial Skin ... or through an intravenous injection (if patient is older than 18 years old).[4] ... following administration of the drug either orally or intravenously.[4][6] Once activated, tedizolid exerts its bacteriostatic ...
After intravenous infusion it is extensively metabolised in the liver by cytochrome p450. More than 95% of the drug is bound to ... In March 2008, Cephalon received approval from the United States Food and Drug Administration to market bendamustine in the US ...
administration. oral, intravenous. ATC code. *C02AC02 (WHO) Legal status. Legal status. *AU: S4 (Prescription only) ...
The U.S. Food & Drug Administration (FDA) has ruled that vinpocetine, due to its synthetic nature and proposed therapeutic uses ... this effect tends to be reversible upon cessation of vinpocetine administration, with full remission typically occurring within ... administration. Oral, intravenous. ATC code. *N06BX18 (WHO) Legal status. Legal status. *US: Withdrawn ...
administration. Intravenous, rectal. ATC code. *N01AF01 (WHO) N05CA15 (WHO). Legal status. Legal status. *AU: S4 (Prescription ...
The two types of response seen with administration of L-DOPA are:. *The short-duration response is related to the half-life of ... More serious are the effects of chronic L-DOPA administration in the treatment of Parkinson's disease, which include:. *End-of- ... Excessive peripheral dopamine signaling causes many of the adverse side effects seen with sole L-DOPA administration. To bypass ... This metabolic pathway is nonexistent in the healthy body, but becomes important after peripheral L-DOPA administration in ...
Route of administration[edit]. rFVIIa is normally administered intravenously (IV) under physician supervision. ... administration. Intravenous injection. ATC code. *B02BD05 (WHO) Legal status. Legal status. *US: ℞-only ...
... for systemic administration is available as an oral tablet, an intramuscular injection, and as a solution for ... intravenous infusion.[15] Furthermore, levothyroxine is available as both brand-name and generic products.[11] While the United ... According to the U.S. Food and Drug Administration pregnancy categories, levothyroxine has been assigned Pregnancy Category A.[ ... States Food and Drug Administration (FDA) approved the use of generic levothyroxine for brand-name levothyroxine in 2004, the ...
... after either ophthalmic or intravenous administration.[20] However, ophthalmic use is done with sterile filtered drugs that is ... it does not correct hyponatremia as rapidly as administration of hypertonic saline does. Due to hypertonicity, administration ... NS is used frequently in intravenous drips (IVs) for people who cannot take fluids orally and have developed or are in danger ... Campbell-Falck, D; Thomas, T; Falck, TM; Tutuo, N; Clem, K (January 2000). "The intravenous use of coconut water". The American ...
administration. Oral, intranasal, intravenous. Legal status. Legal status. *CA: Schedule I *DE: Anlage II (Authorized trade ...
administration. oral, vaginal, intravenous. ATC code. *G02CB01 (WHO) N04BC01 (WHO). Legal status. ...
administration. Medical: Inhalation (nasal). Recreational: Oral, intravenous, insufflation, inhalation, suppository. Legal ... In a study of psychoactive effects of levomethamphetamine, the intravenous administration of 0.5 mg/kg (but not 0.25 mg/kg) in ... "United States Food and Drug Administration. April 2015. Archived from the original on 18 September 2015. Retrieved 7 March 2016 ... The study did not test the oral administration of levomethamphetamine. As of 2006, there were no studies demonstrating "drug ...
"U.S. Food and Drug Administration (FDA).. *Ebola: What You Need to Know - Scientific American articles related to Ebola; note ... or giving intravenous fluids as well as treating symptoms.[1] Atoltivimab/maftivimab/odesivimab (Inmazeb) was approved for ... "U.S. Food and Drug Administration (FDA) (Press release). 14 October 2020. Retrieved 14 October 2020.. This article incorporates ... "U.S. Food and Drug Administration (FDA) (Press release). 20 December 2019. Retrieved 22 December 2019.. ...
Administration of corticotropin releasing hormone (CRH) can differentiate this condition from ectopic ACTH secretion. In a ... The CRH test uses recombinant human or bovine-sequence CRH, which is administered via a 100μg intravenous bolus dose. The ...
administration. intravenous infusion only (never bolus or "push"). ATC code. *L01XC02 (WHO) ... Based on its safety and effectiveness in clinical trials,[42] rituximab was approved by the U.S. Food and Drug Administration ... Originally available for intravenous injection (e.g. over 2.5 hrs), in 2016 it gained EU approval in a formulation for ... Rituximab Information from the US Food and Drug Administration. *U.S. National Library of Medicine: Drug Information Portal - ...
... depending on the route of administration. Topically administered corticosteroids in the mouth may take the form of mouthwashes ... may require systemic treatment with oral or intravenous administered anti-fungals. If candidiasis is secondary to ...
1957). "Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy". New England Journal of Medicine ... Prior to the administration of new cells (engraftment) patients may go for several weeks without appreciable numbers of white ... Mucositis is treated with pain medications plus intravenous infusions to prevent dehydration and malnutrition. ...
Based on its safety and effectiveness in clinical trials,[42] rituximab was approved by the U.S. Food and Drug Administration ... Originally available for intravenous injection (e.g. over 2.5 hrs), in 2016 it gained EU approval in a formulation for ... Rituximab Information from the US Food and Drug Administration. *U.S. National Library of Medicine: Drug Information Portal - ... "Treatment of Pemphigus Vulgaris with Rituximab and Intravenous Immune Globulin". N Engl J Med. 355 (17): 1772-1779. doi:10.1056 ...
Intravenous administration of ceftriaxone is recommended as the first choice in these cases;[23] cefotaxime and doxycycline are ... intravenous and intramuscular penicillin and intravenous ceftriaxone.[263][264] The mechanism of tick transmission was also the ... intravenous antibiotics are preferred for retreatment in case of poor response to oral antibiotics.[23][30] Outside of that, a ... oral administration of doxycycline is widely recommended as the first choice, as it is effective against not only Borrelia ...
... begins with the contraction of the muscles attached to the rib cage; this causes an expansion in the chest cavity. Then takes place the onset of contraction of the diaphragm, which results in expansion of the intrapleural space and an increase in negative pressure according to Boyle's law. This negative pressure generates airflow because of the pressure difference between the atmosphere and alveolus. Air enters, inflating the lung through either the nose or the mouth into the pharynx (throat) and trachea before entering the alveoli.[citation needed] Other muscles that can be involved in inhalation include:[2] ...
In 2005 the U.S. Food and Drug Administration (FDA) accepted Cortex Pharmaceuticals' Investigational New Drug (IND) application ... effects of the ampakine drugs on the pre-Botzinger complex of the brain has led to continued development of an intravenous ...
Intravenous interferon therapy has also been used.[citation needed] When Lassa fever infects pregnant women late in their third ... After extensive testing, early administration was determined to be critical to success. Additionally, ribavirin is almost twice ...
"Food and Drug Administration. Retrieved 2009-06-14.. *^ Johnson, Craig (April 22, 2009). "Scrutiny in horse deaths falls on ... U.S. Food and Drug Administration. July 8, 2003. Archived from the original on January 15, 2008. Retrieved April 24, 2009.. ... Intravenous therapy. *Electrolyte. *Oral rehydration therapy. *Polo pony. *Endurance riding. References[edit]. *^ a b "BIODYL" ... The Associated Press reported erroneously that the Food and Drug Administration had refused to approve the French-made ...
Some feel that the term tisane is more correct than herbal tea or that the latter is even misleading, but most dictionaries record that the word tea is also used to refer to other plants beside the tea plant and to beverages made from these other plants.[4][5] In any case, the term herbal tea is very well established and much more common than tisane.[1] The word tisane was rare in its modern sense before the 20th century, when it was borrowed in the modern sense from French. (This is why some people feel it should be pronounced /tɪˈzɑːn/ as in French, but the original English pronunciation /tɪˈzæn/ continues to be more common in US English and especially in UK English).[2] The word had already existed in late Middle English in the sense of "medicinal drink" and had already been borrowed from French (Old French). The Old French word came from the Latin word ptisana, which came from the Ancient Greek word πτισάνη (ptisánē), which meant "peeled" barley, in other words pearl barley, ...
Intravenous administration of the drug to dogs, in doses of ~ 6 - 18 mg/kg, was found to produce significant mydriasis (a 100% ... The pharmacokinetics of N-methylphenylethanolamine, after i.v. administration to dogs, were studied by Shannon and co-workers, ... administration in a cat preparation: a total dose of 5 x 10−6 M (or ~ 1 mg of the HCl salt) caused a maximum rise in blood ... in Australia involved the administration of doses up to 100 mg/kg, i.v., in sheep, and 100 mg/kg, i.p., in guinea pigs, without ...
Hospital pharmacies typically engage in compounding medications for intravenous administration, whereas outpatient or community ... "Food and Drug Administration. January 10, 2002. Retrieved 2014-02-18.. *^ Boothby LA, Doering PL (August 2008). "Bioidentical ... Therapeutic Goods Administration. December 1997. Retrieved 2017-02-21.. *^ "International Academy of Compounding Pharmacists: ... "Food and Drug Administration. 2012-12-03. Archived from the original on January 7, 2015. Retrieved 2012-12-19.. ...
Usefulness of the prick test for anaphylactoid reaction in intravenous fluorescein administration]". Nippon Ganka Gakkai Zasshi ... Topical, oral, and intravenous use of fluorescein can cause adverse reactions, including nausea, vomiting, hives, acute ... Intravenous use has the most reported adverse reactions, including sudden death, but this may reflect greater use rather than ... Intravenous or oral fluorescein is used in fluorescein angiography in research and to diagnose and categorize vascular ...
Blood cultures obtained prior to antibiotic administration.. *serum lactate measured. *Broad-spectrum antibiotics administered ... Intravenous fluids. *Neuromuscular-blocking drugs. *Recombinant activated protein C. *Sedatives. *Stress ulcer prevention drugs ...
... intravenous - intravenous immunoglobulin (IVIG) - intravitreal - Investigational New Drug (IND) - IRB - ITP - IVIG ... fat redistribution - FDA FDC - floaters - follicle - follicular dendritic cells (FDCs) - Food and Drug Administration (United ... HAART - hairy leukoplakia - half-life - HAM/TSP - Health Care Financing Administration (HCFA) - Health Resources and Services ... administration - Adult AIDS Clinical Trials Group (AACTG) - adverse drug reaction - aerosolized - AETC - agammaglobulinemia - ...
... mesylate administration should be undertaken with caution to patients with glaucoma or raised intraocular pressure ... Since fenoldopam is the only intravenous agent that improves renal perfusion, in theory it could be beneficial in hypertensive ... It was approved by the Food and Drug Administration (FDA) in September 1997.[3] ...
Check date values in: ,date= (help) "A Safety and Dose Ranging Study of Idursulfase (Intrathecal) Administration Via an ... a phase I/II clinical trial evaluated intrathecal injections of a more concentrated dose of idursulfase than the intravenous ... underwent clinical trial in 2006 and was subsequently approved by the United States Food and Drug Administration as an enzyme ... Safety and Ascending Dose Ranging Study of Intrathecal Idursulfase-IT Administered in Conjunction With Intravenous Elaprase in ...
"Food and Drug Administration (FDA). 8 March 2018. Archived from the original on 18 July 2019. Retrieved 17 July 2019.. ... a dose of intravenous ceftriaxone is often prescribed.[3] Trimethoprim/sulfamethoxazole or amoxicillin/clavulanate orally for ... a longer course or intravenous antibiotics may be needed.[6] If symptoms do not improve in two or three days, further ... The Food and Drug Administration (FDA) recommends against the use of fluoroquinolones when other options are available due to ...
To avoid side-effects associated with intravenous administration, the solution should be slowly infused to minimize the release ... Intravenous solutions of pentamidine can be mixed with intravenous HIV medications like zidovidine and intravenous heart ... For intravenous and intramuscular use:[8] *US and Canada: *Pentacarinat 300 injection powder 300 mg vial (Avantis Pharma Inc - ... Ample fluids or intravenous hydration may prevent some nephrotoxicity.[9]. *Liver: Elevated liver enzymes are associated with ...
Aside from the intravitreal administration of the pegaptanib, it was also found that subcutaneous and intravenous routes of ... Means of administration[edit]. Pegaptanib is administered in a 0.3 mg dose once every six weeks by intravitreal injection. An ... Toxicology studies were conducted in rhesus monkeys, guinea pigs, rats, mice, and rabbits.[5] After the administration of the ... Approval was granted by the U.S. Food and Drug Administration (FDA) in December 2004.[4] ...
With oral administration absorption efficiency decreases as amounts increase. Intravenous administration bypasses this.[41] ... a b c U.S. Food and Drug Administration: "Listing of Food Additives Status Part I". Archived from the original on January 17, ... U.S. Food and Drug Administration: "Listing of Food Additives Status Part II". Retrieved October 27, 2011.. ... Treatment can be orally or by intramuscular or intravenous injection.[2] Scurvy was known to Hippocrates in the classical era. ...
Zyflo (Zileuton tablets)»։ United States Food and Drug Administration։ Cornerstone Therapeutics Inc.։ June 2012։ էջ 1։ ... 156,0 156,1 Nair Parameswaran, Milan Stephen J., Rowe Brian H. (2012-12-12)։ «Addition of intravenous aminophylline to inhaled ... Travers Andrew H., Milan Stephen J., Jones Arthur P., Camargo Carlos A., Rowe Brian H. (2012-12-12)։ «Addition of intravenous ... Kew KM, Kirtchuk L, Michell CI (մայիսի 28, 2014)։ «Intravenous magnesium sulfate for treating adults with acute asthma in the ...
administration. intravenous, intramuscular, subcutaneous, intrapleural, intratumoral. ATC code. *L01DC01 (WHO) Legal status. ... In our studies, mice developed classic PF with structural alteration of the lung following intravenous bleomycin treatment. ...
Compared with other routes of administration, such as oral medications, the intravenous route is the fastest way to deliver ... The intravenous route of administration can be used for injections (with a syringe at higher pressures) or infusions (typically ... Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous). ... such as when there is insufficient uptake by other routes of administration such as enterally. Examples include intravenous ...
MDPV has been shown to produce robust reinforcing effects and compulsive self-administration in rats, though this had already ... Reported modalities of intake include oral consumption, insufflation, smoking, rectal and intravenous use. It is supposedly ... "Chemicals Used in "Bath Salts" Now Under Federal Control and Regulation" (Press release). Drug Enforcement Administration (DEA ...
There are many variations in the routes of administration, including intravenous (into the blood through a vein) and oral ... Administration is the process by which a patient takes a medicine. There are three major categories of drug administration; ... require special handling during administration, require patient monitoring during and immediately after administration, have ... In the U.S., the Elixir Sulfanilamide disaster led to the establishment of the Food and Drug Administration, and the 1938 ...
... is disclosed which is capable of introducing fluid from a plurality of sources of intravenous fluids into a patient and which ... to the sources of intravenous fluid. The air-eliminating filter (32) ensures that air or bacteria introduced into the assembly ... The present invention relates to intravenous administration sets in general and, in particular, to intravenous administration ... 1. An intravenous administration set assembly capable of use with at least three differing sources of intravenous fluid ...
... promethazine intravenous administration promethazine intravenous administration. phenergan intravenous administration ... Phenergan intravenous administration. Phenergan intravenous administration. July 10, 2017 by Filed under Provigil dosage weight ... pyrogen-free solution for deep intramuscular phenergan intravenous administration or intravenous administration. 25-15mg/5ml, ... Phenergan intravenous administration: Para Que Sirve Gemfibrozilo De 300 Mg; Orlistat 120 Mg Com 42 Cpsulas - Neo Quimica - ...
A method of preparing gamma globulin suitable for intravenous administration comprising a first step of treating a supernatant ... Lyophilized native gamma globulin preparation for intravenous administration. US4276283 *. Sep 10, 1979. Jun 30, 1981. Immuno ... albumin and which is suitable for intravenous administration, comprising the steps of:. mixing together a sample of human blood ... albumin and which is suitable for intravenous administration, comprising the steps of:. mixing together a sample of human blood ...
Cerebrospinal Fluid Distribution of Ibuprofen After Intravenous Administration in Children. Hannu Kokki, Elina Kumpulainen, ... Cerebrospinal Fluid Distribution of Ibuprofen After Intravenous Administration in Children. Hannu Kokki, Elina Kumpulainen, ... Cerebrospinal Fluid Distribution of Ibuprofen After Intravenous Administration in Children Message Subject (Your Name) has sent ... Cerebrospinal Fluid Distribution of Ibuprofen After Intravenous Administration in Children. Hannu Kokki, Elina Kumpulainen, ...
... (Received 20 March 1997 ... Title Postmortem Amitriptyline Pharmacokinetics in Pigs after Oral and Intravenous Routes of Administration. Symposium , ... and metabolites in pigs after oral and intravenous administration, and the results are compared with previous studies in rats ... Of a total of 9 over-night fasted pigs, 3 were given 25 mg/Kg Ami orally, and another 3 pigs received an intravenous infusion ...
Epoprostenol Powder for Intravenous Administration) may treat, uses, dosage, side effects, drug interactions, warnings, patient ... epoprostenol) Powder for Intravenous (IV) Administration. DESCRIPTION. Epoprostenol sodium is the sodium salt of epoprostenol, ... Administration. VELETRI, once prepared as directed [see Reconstitution], is administered by continuous intravenous infusion via ... home drugs a-z list side effects drug center veletri (epoprostenol powder for intravenous administration) drug ...
The Therapeutic Goods Administration (TGA) advises that Octapharma Australia Pty Ltd has agreed to a precautionary voluntary ... Although thromboembolic events are a known rare adverse event associated with the administration of all intravenous ... Octagam intravenous immunoglobulin solutions. Related information. Later information. *Octagam 5%: lifting of the voluntary ... The Therapeutic Goods Administration (TGA) advises that Octapharma Australia Pty Ltd has agreed to a precautionary voluntary ...
... and/or nutrients contained in respective liquid containers includes a plurality of liquid intravenous administration sets, each ... the flow path being bounded over a portion of its length by a flexible intravenous tube, and a plurality of indicia, each ... administration set defining a flow path from a point of entry adapted to be fluidly connected to a respective liquid container ... liquid reservoirs containing one of the medicaments and/or nutrients and associated with a respective one of the administration ...
... for Intravenous Administration) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and ... Administration. For intravenous use only.. *Inspect reconstituted KOVALTRY visually for particulate matter and discoloration ... DOSAGE AND ADMINISTRATION. For intravenous use after reconstitution only.. Dose. *Dosage and duration of treatment depend on ... home drugs a-z list side effects drug center kovaltry (antihemophilic factor (recombinant) for intravenous administration) drug ...
intravenous administration of C1-Inhibitor, after the end of the first observation period (at least after 7 days), each arm ... In case of acute oedema in patients suffering from HAE, the intravenous administration of C1-INH concentrate (e.g., Berinert P ... The study is performed to investigate the subcutaneous (s.c.) versus intravenous (i.v.) administration of Berinert P in ... Berinert P Study of Subcutaneous Versus Intravenous Administration (PASSION). This study has been completed. ...
Notes from the Field: Adverse Events Associated with Administration of Simulation Intravenous Fluids to Patients - United ... A sample of the simulated saline product inadvertently administered to multiple patients as sterile intravenous fluid, with ... Simultaneously, the Food and Drug Administration issued an alert, warning health care professionals not to use any Wallcur ... Both patients experienced a febrile illness during product administration and were hospitalized; one patient developed sepsis ...
Intravenous (IV) iron is widely used to treat anemia in chronic kidney disease patients. Previously, iron formulations were ... Intravenous (IV) iron is widely used to treat anemia in chronic kidney disease patients. Previously, iron formulations were ... Administration of Intravenous Iron Formulations Induces Complement Activation in-vivo. Bernardo Faria1,2,3†, Mariana Gaya da ... Slow intravenous iron administration does not aggravate oxidative stress and inflammatory biomarkers during hemodialysis: a ...
... ... "Frequency of acute kidney injury following intravenous contrast medium administration: a systematic review and meta-analysis," ... R. J. McDonald, J. S. McDonald, J. P. Bida et al., "Intravenous contrast material-induced nephropathy: causal or coincident ... "Contrast material-induced nephrotoxicity and intravenous low-osmolality iodinated contrast material," Radiology, vol. 267, no. ...
Cx611-0101, eASCs Intravenous Administration to Refractory Rheumatoid Arthritis Patients. The safety and scientific validity of ... Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis ( ... single blind clinical trial to assess the safety of the intravenous administration of expanded allogeneic adipose-derived ... Phase Ib/IIa, Escalating Dose, Single Blind, Clinical Trial to Assess the Safety of the i.v Administration of Allogeneic ...
AACR 2021-ImmVira presents the preclinical study results of MVR-T3011 via intravenous administration - read this article along ... and repeated dose via intravenous administration has clearly enhanced antitumor effect. Furthermore, intravenous administration ... AACR 2021-ImmVira presents the preclinical study results of MVR-T3011 via intravenous administration. Published: Apr 19, 2021 ... ImmVira submitted an IND application for MVR-T3011 intravenous administration to the U.S. FDA in January 2021 and expects to ...
... ... PHARMACOKINETICS OF ENROFLOXACIN AFTER SINGLE DOSE ORAL AND INTRAVENOUS ADMINISTRATION... PHARMACOKINETICS OF AZITHROMYCIN IN ... "Marbofloxacin Disposition After Intravenous Administration of a Single Dose in Wild Mallard Ducks (Anas platyrhynchos)," ... "Marbofloxacin Disposition After Intravenous Administration of a Single Dose in Wild Mallard Ducks (Anas platyrhynchos)," ...
Epidemiologic Notes and Reports Outbreak of Hepatitis C Associated with Intravenous Immunoglobulin Administration -- United ... On February 21, 1994, the Food and Drug Administration (FDA) was notified of 14 possible cases from three different countries ... Preliminary analysis of data from epidemiologic studies suggests that HCV transmission is not related to the administration of ... Editorial Note: The temporal association of acute hepatitis C with Gammagard {Registered} administration and the absence of ...
... today announced an oral presentation showing that intravenous (IV)... ... This drug could be the first macrolide since azithromycin to offer both oral and intravenous forms of administration. This will ... Intravenous administration demonstrated favorable pharmacokinetics and achieved clinically-relevant plasma concentrations. --- ... Intravenous (IV) Administration of Cempra Pharmaceuticals Solithromycin (CEM-101) Demonstrates Excellent Systemic Tolerability ...
This research suggests that the intravenous administration of MSC-spheroids may constitute an effective new approach for the ... enabling their intravenous administration and access to the brain. It is shown, in an animal model of chronic ethanol intake ... that both the intravenous and intra-cerebroventricular administration of a single dose of MSC-spheroids inhibited chronic ... The MSC-spheroid administration fully normalized alcohol-induced neuroinflammation, as shown by a reduced astrocyte activation ...
The provision of fat during intravenous feeding is essential, but the potentially toxic byproducts of fatty acid oxidation may ... Effect of L-glutamine supplementation on impaired glucose regulation during intravenous lipid administration Nutrition. 1996 ... In conclusion, these data show that glutamine supplementation during intravenous lipid administration in rats prevents the ... The provision of fat during intravenous feeding is essential, but the potentially toxic byproducts of fatty acid oxidation may ...
... administration of contrast medium (CM) for opacifcation of the upper urinary tract (UUT) for multidetector computed tomography ... The optimal delay time after intravenous (i.v.) ... The optimal delay time after intravenous (i.v.) administration ... MDCT urography: retrospective determination of optimal delay time after intravenous contrast administration. ... Dyer RB, Chen MY, Zagoria RJ (2001) Intravenous urography: technique and interpretation. Radiographics 21:799-824PubMedGoogle ...
PRNewswire/ -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the U.S. Food and Drug Administration (FDA) ... The intravenous administration trial was conducted at 10 centers in the U.S. and recruited a total of 30 patients, of which 24 ... Administration of Erwinaze through an intravenous infusion provides physicians another option for patients, including those who ... Jazz Pharmaceuticals Receives FDA Approval For Intravenous Administration Of Erwinaze® (asparaginase Erwinia chrysanthemi) ...
... this complication is not well known in ischemic stroke patients who receive intravenous (IV) t-PA ... Infusions, Intravenous. Myocardium / pathology. Paresis / etiology. Stroke / complications*, drug therapy. Thrombolytic Therapy ... this complication is not well known in ischemic stroke patients who receive intravenous (IV) t-PA.. METHODS: Case report. ...
Duret haemorrhage during intravenous administration of thrombolytic therapy Hemorragia de Duret durante la perfusión de ... Inicio Neurología (English Edition) Duret haemorrhage during intravenous administration of thrombolytic therapy ... Clinical deterioration and early imaging changes after intravenous tissue plasminogen activator administration in acute ... Intravenous tissue-type plasminogen activator for treatment of acute stroke: the Standard Treatment with Alteplase to Reverse ...
As shown here, intravenous administration of HuUCBMCs significantly raised the phospho-Akt/Akt ratio in the cerebellum and ... Effects of Intravenous Administration of Human Umbilical Cord Blood Stem Cells in 3-Acetylpyridine-Lesioned Rats. Lucía ... S. Garbuzova-Davis, A. E. Willing, T. Zigova et al., "Intravenous administration of human umbilical cord blood cells in a mouse ... Here, we report that intravenous administration of HuUCB mononuclear cells (HuUCBMCs) reaches the cerebellum and brain stem of ...
A Study of Diazepam After Intranasal and Intravenous Administration to Healthy Volunteers. This study has been completed. ... A Study of Diazepam After Intranasal and Intravenous Administration to Healthy Volunteers. ... and injectable diazepam after intravenous (I.V.) administration. Bioavailability is a measure of how much drug is absorbed ... and injectable diazepam after intravenous (I.V.) administration. ... It was approved by the Food and Drug Administration (FDA) for ...
Intestinal Infarction after Intravenous Cocaine Administration Ronald S. Freudenberger, MD; Mitchell S. Cappell, MD, PhD; ... Intestinal Infarction after Intravenous Cocaine Administration. Ann Intern Med. ;113:715-716. doi: 10.7326/0003-4819-113-9-715 ... We report a case of acute mesenteric ischemia after intravenous administration of cocaine, which extends previously reported ... A 38-year-old thin male intravenous cocaine abuser was found at work to be lethargic but arousable after intravenously self- ...
Effects of Perioperative Administration of Intravenous Ibuprofen or Intravenous Parecoxib on Morphine Consumption. Kirollos, ... Effects of Perioperative Administration of Intravenous Ibuprofen or Intravenous Parecoxib on Morphine Consumption ...
Population pharmacokinetic modeling of LY2189102 after multiple intravenous and subcutaneous administrations.. Bihorel S1, ... Population Pharmacokinetic Modeling of LY2189102 after Multiple Intravenous and Subcutaneous Administrations. AAPS J. 2014 Sep; ... Population Pharmacokinetic Modeling of LY2189102 after Multiple Intravenous and Subcutaneous Administrations. AAPS J. 2014 Sep; ... Population Pharmacokinetic Modeling of LY2189102 after Multiple Intravenous and Subcutaneous Administrations. AAPS J. 2014 Sep; ...
... includes a plurality of liquid intravenous administration sets (32), each administration set (32) defining a flow path from a ... the flow path being bounded over a portion of its length by a flexible intravenous tube (36), and a plurality of indicia, each ... liquid reservoirs containing one of the medicaments and/or nutrients and associated with a respective one of the administration ... A system for the intravenous administration of a plurality of medicaments and/or nutrients contained in respective liquid ...
  • In addition a meticulous investigation of blood and tissue concentrations after postmortem intravenous infusion of Ami was undertaken. (astm.org)
  • Of a total of 9 over-night fasted pigs, 3 were given 25 mg/Kg Ami orally, and another 3 pigs received an intravenous infusion lasting 1 h of 3.3 mg/Kg Ami prior to death. (astm.org)
  • The final 3 pigs were sacrificed and then given the intravenous infusion after death. (astm.org)
  • Temporary peripheral intravenous infusion may be used until central access is established. (rxlist.com)
  • The primary objective of the study is to determine the safety, feasibility and tolerance, and to identify, if possible, the dose limiting toxicity (DLT) and the dose for future clinical trials on efficacy of the intravenous infusion of allogeneic eASCs for patients suffering rheumatoid arthritis (RA) under treatment with at least one non-biologic-Disease modifying antirheumatoid drug (DMARD) who have previously failed to treatment with at least two biologics. (clinicaltrials.gov)
  • The secondary objective is to obtain information on the clinical and functional effects of the intravenous infusion of allogeneic eASCs in patients with RA and to explore pharmacodynamics parameters. (clinicaltrials.gov)
  • Administration of Erwinaze through an intravenous infusion provides physicians another option for patients, including those who cannot tolerate intramuscular injections,' said Jeffrey Tobias , M.D., executive vice president, research and development and chief medical officer of Jazz Pharmaceuticals plc. (prnewswire.co.uk)
  • With the expanded label, the formulation of Erwinaze currently on the market may now be administered to patients by either intravenous infusion or intramuscular injection. (prnewswire.co.uk)
  • Erwinaze® (asparaginase Erwinia chrysanthemi ) is currently approved in the U.S. for administration via intramuscular injection or via intravenous infusion in conjunction with chemotherapy. (prnewswire.co.uk)
  • Outpatient infusion therapy may include administration of nutrition, antibiotic therapy, and fluid and electrolyte repletion. (ucsf.edu)
  • The administration of complex outpatient infusion therapy in AIDS patients is driven by patient needs as well as by cost demands. (ucsf.edu)
  • ISSUE: In April 2015, Mylan Institutional conducted a voluntary market withdrawal of 14 lots of Calcium Chloride Intravenous Infusion 10% w/v, packaged in 10 mL prefilled syringes. (asahq.org)
  • BACKGROUND: Calcium Chloride Intravenous Infusion 10% w/v is used as part of the resuscitation procedure following a cardiac arrest and for the treatment of low calcium levels. (asahq.org)
  • Because of the use of Calcium Chloride Intravenous Infusion prefilled syringes in emergency situations, and its use as a lifesaving drug, difficulty in the administration of the drug could create a potential risk by prohibiting or delaying the administration of the medication. (asahq.org)
  • Intravenous infusion is the method that a large volume of solution infused into body to handle fluid and electrolyte disturbance. (powershow.com)
  • Here we argue that there is another, underexplored dimension to "precision" oncology: the adoption of targeted alternatives to intravenous infusion, such as intratumoral delivery, delivery via locoregional vasculature and lymphatic delivery. (ttp.com)
  • in addition, separate groups of rats were treated with methylphenidate (2.5 mg/kg) or saline before 12 consecutive nicotine (0.03 mg/kg/infusion) self-administration sessions. (uky.edu)
  • For inpatient use, bar code medication administration (BCMA) and Smart IV pumps with wireless connectivity are connected seamlessly with the EHR creating Intelligent infusion systems for auto-programming and auto-documentation. (apsf.org)
  • IVTEAM provide the largest free global online intravenous resource for infusion and vascular access practitioners. (ivteam.com)
  • METHODS AND RESULTS: Sixty-nine patients from 12 centres were randomly assigned at a 2:1 ratio to levosimendan or placebo groups, receiving treatment by a 6-hour intravenous infusion (0.2 μg/kg/min without bolus) every 2 weeks for 12 weeks. (ivteam.com)
  • Infusion set/Intravenous Administration set/IV Set/Perfusion set/Gravity set:Made from Non-toxic Medical Grade PVC Compound.Suitable for Gravity Infusion.Clear , transparent , flexible chamber with filter. (toboc.com)
  • Intravenous Ascorbic Acid (also known as vitamin C or L-ascorbic acid), is a type of therapy that delivers soluble ascorbic acid directly into the bloodstream, either administered via injection or infusion. (wikipedia.org)
  • High doses of ascorbic acid administered by intravenous infusion have been shown to increase the absorption of iron. (wikipedia.org)
  • In 1976, Pauling and Cameron co-authored a study whereby a group of 100 terminal cancer patients underwent supplementary ascorbic acid therapy (10g/day by intravenous infusion and oral thereafter) and the control group of 1,000 patients did not. (wikipedia.org)
  • Intravenous (IV) iron infusion is a therapy in which a combination of iron and saline solution is delivered directly into the bloodstream through a vein, in patients suffering iron deficiency, iron-deficiency anaemia and chronic kidney disease. (wikipedia.org)
  • 2. An intravenous administration set assembly as claimed in claim 1 wherein the tubing means (38, 46, 56) connected between the air-eliminating filter (32) and the adapter (58) includes at least one fitting (52) having an injection site (54) provided therein so that injections of medication to the patient can easily be made in the course of intravenous administrations of fluid to a patient. (google.com.au)
  • PHENERGAN (promethazine HCl) Injection, is a sterile, pyrogen-free solution for deep intramuscular phenergan intravenous administration or intravenous administration. (drowsydriving.org)
  • Promethazine (Injection Route, Intravenous Route) Print. (drowsydriving.org)
  • A total 36 healthy children (25 boys) aged 3 months to 12 years received a single intravenous injection of ibuprofen (10 mg/kg). (aappublications.org)
  • Ibuprofen penetrates the cerebrospinal fluid readily, with peak concentrations attained 30 to 40 minutes after intravenous injection of a 10 mg/kg dose. (aappublications.org)
  • The goal of this study was to determine the disposition kinetics of marbofloxacin in mallard ducks ( Anas platyrhynchos ) after a single intravenous injection. (bioone.org)
  • Prior to this approval, the only approved route of administration for Erwinaze was through intramuscular injection. (prnewswire.co.uk)
  • It was approved by the Food and Drug Administration (FDA) for use in the United States and is currently sold as Valium® tablets, Diazepam Injection and Diastat® rectal gel. (clinicaltrials.gov)
  • However, the adverse health effects resulting from intravenous injection of SWNTs are not completely understood. (dovepress.com)
  • Studies have shown that levels of "pristine" or carboxylated carbon nanotubes are very high in mouse lungs after intravenous injection. (dovepress.com)
  • Long-term intravenous injection of c-SWNTs caused sustained embolization in lung capillaries and granuloma formation. (dovepress.com)
  • In this report, we examined the ability of ONYX-015 to infect and replicate in s.c. tumors following either ( a ) direct injection into and replication within a distant tumor or ( b ) i.v. administration. (aacrjournals.org)
  • Under sodium pentobarbital anesthesia (25-35 mg/kg), serum, CSF and inner ear fluids from scala tympani perilymph, scala vestibuli perilymph, and scala media endolymph were collected from normal guinea pigs after the oral administration of glycerol (50%, 12 ml/kg) or the intravenous injection of glycerol (1.0 ml/kg). (unboundmedicine.com)
  • The K concentration did not change significantly after intravenous injection. (unboundmedicine.com)
  • Scala vestibuli perilymph: The Na level increased slowly and steadily only after oral administration of glycerol, and the K level increased slightly after intravenous injection. (unboundmedicine.com)
  • In the diagnosis of Meniere's disease, oral administration of glycerol is more effective than intravenous injection. (unboundmedicine.com)
  • The plasma half-life of 125I-tissue kallikrein up to 3 h after intravenous injection was 9 min and, thereafter, 20 h. (lu.se)
  • There are several advantages offered by SbQ amifostine over IV amifostine including easier administration and a favorable window between drug injection and radiation delivery. (oncolink.org)
  • In the initial phase of these clinical studies, intravenous (iv) injection was used according to the route used in pre-clinical efficacy studies. (ovid.com)
  • The gradual absorbance into the blood stream and lower maximal blood levels of ALT-803 in sc-injected mice, along with similar anti-tumor efficacy support the administration of ALT-803 by sc injection in patients with various malignancies and infectious diseases. (ovid.com)
  • Eight ruminally cannulated Angus × Hereford steers (485 ± 16 kg BW) were housed in individual pens on d -7, ranked by BW, and allocated to 1 of 2 treatments administered on d 0: 1) an intravenous (i.v.) bolus dose (0.5 μg/kg of BW, diluted in 5 mL of 0.9% sterile saline) of bacterial LPS ( 0111:B4) or 2) a 5-mL i.v. injection of 0.9% sterile saline (CON). (oregonstate.edu)
  • Taken together, these data indicate that 1-hydroxyethyl radicals are formed in vivo and can be readily detected in bile when high concentrations of POBN are achieved through intravenous injection. (aspetjournals.org)
  • Comparative pharmacokinetics of syringin, eleutheroside E and isofraxidin in rat plasma after intravenous administration of each monomer and Ciwujia injection]. (nextbio.com)
  • In this study we have evaluated the postmortem pharmacokinetics of amitriptyline (Ami) and metabolites in pigs after oral and intravenous administration, and the results are compared with previous studies in rats and humans. (astm.org)
  • James W. Carpenter , John H. Olsen , Mary Randle-Port , David E. Koch , Ramiro Isaza , and Robert P. Hunter "PHARMACOKINETICS OF AZITHROMYCIN IN THE BLUE AND GOLD MACAW ( ARA ARARAUNA ) AFTER INTRAVENOUS AND ORAL ADMINISTRATION," Journal of Zoo and Wildlife Medicine 36(4), 606-609, (1 December 2005). (bioone.org)
  • This study will evaluate two intranasal (nasal spray) formulations of diazepam which will be supplied by Neurelis, Inc. The purpose of this clinical research study is to assess the bioavailability and pharmacokinetics of two formulations of diazepam after intranasal (nasal spray) and injectable diazepam after intravenous (I.V.) administration. (clinicaltrials.gov)
  • Population pharmacokinetics (PK) of LY2189102, a high affinity anti-IL-1β humanized monoclonal immunoglobulin G4 evaluated for efficacy in RA and T2DM, were characterized using data from 79 T2DM subjects (Study H9C-MC-BBDK) who received 13 weekly subcutaneous (SC) doses of LY2189102 (0.6, 18, and 180 mg) and 96 RA subjects (Study H9C-MC-BBDE) who received five weekly intravenous (IV) doses (0.02-2.5 mg/kg). (nih.gov)
  • The pharmacokinetics of salicylic acid (SA) in sheep was evaluated following intravenous (IV) and oral administration of sodium salicylate (sodium salt of salicylic acid) at different doses. (mdpi.com)
  • Pharmacokinetics and bioavailability of mequindox were determined after single intravenous (i.v.) or intramuscular (i.m.) administrations of 7 mg/kg body weight (b.w.) to 10 healthy adult goats. (academicjournals.org)
  • Researchers at Kansas State University and Iowa State University have collaborated to study the pharmacokinetics of the analgesic, flunixin meglumine, administered to mature pigs by the intravenous (IV), intramuscular (IM) and oral (PO) routes. (thepigsite.com)
  • Population Pharmacokinetics of High-dose Methotrexate After Intravenous Administration in Chinese Osteosarcoma Patients from a Single Institution. (thefreelibrary.com)
  • S.v. Population Pharmacokinetics of High-dose Methotrexate After Intravenous Administration in Chinese Osteosarcoma Patients from a Single Institution. (thefreelibrary.com)
  • The pharmacokinetics of lotilaner were investigated after intravenous or oral administration and under fed or fasted conditions in cats. (springer.com)
  • Dose-dependent and time-dependent pharmacokinetics in the dog after intravenous administration of dextrorphan. (aspetjournals.org)
  • This was accomplished using a pig microdialysis model to characterize the spinal cord, cerebrospinal fluid (CSF), and plasma pharmacokinetics of methylprednisolone during intravenous and intrathecal administration. (asahq.org)
  • We present the case of a patient who died after a massive brainstem haemorrhage, possibly secondary to a transtentorial herniation (Duret haemorrhage) during treatment of a proximal occlusion of the right middle cerebral artery (MCA) with intravenous recombinant tissue plasminogen activator (rt-PA). (elsevier.es)
  • LVT is not a contraindication for treatment with intravenous recombinant tissue plasminogen activator (IV rtPA) for AIS. (frontiersin.org)
  • The patient had no contraindications to intravenous recombinant tissue plasminogen activator (IV rtPA) and was treated within 60 min of presentation. (frontiersin.org)
  • The purpose of this study is to show that subcutaneous (SC) administration of daratumumab co-formulated with recombinant human hyaluronidase PH20 (Dara SC) is non-inferior to intravenous (IV) administration of daratumumab (Dara IV) in terms of the overall response rate (ORR) and maximum trough concentration (Ctrough). (vchri.ca)
  • Emergency superficial temporal artery to middle cerebral artery bypass after intravenous recombinant tissue plasminogen activator administration for acute cerebral ischemia in a patient with moyamoya disease. (curehunter.com)
  • There are few study data to help in the decision whether to perform aggressive surgical revascularization, such as emergency bypass, after intravenous recombinant tissue plasminogen activator (rt-PA) administration in patients with progressive symptoms due to acute cerebral ischemia . (curehunter.com)
  • provigil bipolar mania Medscape - Motion sickness, nausea, vomiting-specific dosing for Phenergan, Phenadoz (promethazine), Intra-arterial and SC administration are contraindicated Can yellow promethazine dm get you high, phenergan dose for infants, promethazine dm 6. (drowsydriving.org)
  • This study is a multicenter phase Ib/IIa, escalating dose, single blind clinical trial to assess the safety of the intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells (eASCs) to refractory rheumatoid arthritis (RA) patients. (clinicaltrials.gov)
  • MVR-T3855, the surrogate of MVR-T3011 for mouse, was shown to significantly extend the survival time of several mouse with orthotopic tumors including primary and metastatic lung cancer and primary liver cancer, and repeated dose via intravenous administration has clearly enhanced antitumor effect. (biospace.com)
  • It is shown, in an animal model of chronic ethanol intake and relapse-drinking, that both the intravenous and intra-cerebroventricular administration of a single dose of MSC-spheroids inhibited chronic ethanol intake and relapse-like drinking by 80-90%, displaying significant effects over 3-5 weeks. (nature.com)
  • Frequency of anti-drug antibody (ADA) development appears dose-dependent and is different between studies (36.7% in Study H9C-MC-BBDK vs. 2.1% in Study H9C-MC-BBDE), likely due to several factors, including differences in patient population and background medications, administration routes, and assays. (nih.gov)
  • A two-compartment model with dose-dependent bioavailability best characterizes LY2189102 PK following IV and SC administration. (nih.gov)
  • An intravenous administration of sodium salicylate at 100 and 200 mg/kg dose may produce analgesia in sheep, which requires further investigation using pharmacokinetic-pharmacodynamic (PKPD) integration or modelling techniques. (mdpi.com)
  • 1. A pharmaceutical composition enabling delivery after oral or intravenous administration of a therapeutically effective amount of glutathione (reduced) to a mammalian patient comprising: a therapeutic dose of reduced glutathione stabilized in a liposomal pharmaceutical carrier capable of being ingested orally, and notwithstanding that oral administration, capable of delivering glutathione (reduced) in a physiologically active state to improve symptoms of disease. (freepatentsonline.com)
  • This study investigated the tissue distribution and toxic effects of cadmium telluride quantum dots (CdTe-QDs) in male BALB/c mice for up to 1 week after single-dose intravenous injections. (americanelements.com)
  • Methods: In 40 ears of 20 patients with a clinical suspicion of endolymphatic hydrops, MR imaging was performed 4 hours after intravenous administration of a single dose of gadolinium-based contrast material (IV-SD-GBCM). (go.jp)
  • The effective lethal dose was determined and dose-response study was conducted after intravenous administration of CdF in rats. (fluoridealert.org)
  • Retinal, vitreous humor, brain, and cerebrospinal fluid (CSF) foscarnet levels were measured by high-performance liquid chromatography after administration of an intravenous dose of 120 mg/kg of body weight to 32 pigmented rabbits. (asm.org)
  • Each rabbit received 120 mg of foscarnet (Astra Pharmaceutical, Södertälje, Sweden) per kg, as an intravenous dose over a 3-min period, since this is a usual dose in humans during the maintenance treatment of CMV retinitis in patients with AIDS. (asm.org)
  • Perioperative administration of acetaminophen and nonsteroidal antiinflammatory drugs (NSAIDs) has been advocated to provide "multimodal" or "balanced" analgesia that decreases opioid dose requirements and may reduce associated adverse events while reducing postsurgical pain intensity. (asahq.org)
  • HYPOTHESIS/OBJECTIVES: To determine maximally tolerated dose (MTD), dose-limiting toxicity (DLT), and preliminary antitumor activity of intravenous administration of gemcitabine in dogs with advanced solid tumors. (uzh.ch)
  • Gemcitabine was administered as a 30-minute intravenous bolus starting at 800 mg/m(2), using escalation of 50 mg/m(2) increments with 3 dogs per dose level. (uzh.ch)
  • The Third National Acute Spinal Cord Injury Study demonstrated that patients receiving an intensive 24- to 48-h intravenous methylprednisolone regimen (30-mg/kg bolus dose plus 5.4 mg · kg −1 · h −1 ) within 8 h of the injury had improved 6-month recovery compared with placebo-treated patients. (asahq.org)
  • In conclusion, these data show that glutamine supplementation during intravenous lipid administration in rats prevents the development of impaired glucose regulation associated with hyperlipidemia. (nih.gov)
  • In this study, the factors influencing the disposition and biotransformation of 1-BrP were examined in male F344 rats and B6C3F1 mice following inhalation exposure (800 ppm) or intravenous administration (5, 20, and 100 mg/kg). (rti.org)
  • Methylphenidate enhances the abuse-related behavioral effects of nicotine in rats: intravenous self-administration, drug discrimination, and locomotor cross-sensitization. (uky.edu)
  • Intravenous administration of the spin-trapping agent alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone (POBN) to anesthetized but otherwise untreated rats was used to test for formation of 1-hydroxyethyl radicals in vivo. (aspetjournals.org)
  • The study is performed to investigate the subcutaneous (s.c.) versus intravenous (i.v.) administration of Berinert P in patients with hereditary angioedema (HAE) to establish a second administration mode in cases where i.v. access is not suitable. (clinicaltrials.gov)
  • In the present study, human mesenchymal stem cells (MSCs) were cultured in 3D-conditions to generate MSC-spheroids, which greatly increased MSCs anti-inflammatory ability and reduced cell volume by 90% versus conventionally 2D-cultured MSCs, enabling their intravenous administration and access to the brain. (nature.com)
  • Subcutaneous (SbQ) Versus Intravenous (IV) Administration of Amifostine for Head and Neck (HN) Cancer Patients Receiving Radiotherapy (RT): Prelimi. (oncolink.org)
  • Comparison of intravenous versus intraperitoneal administration of oncolytic herpes simplex virus 1 for peritoneal carcinomatosis in mice. (harvard.edu)
  • Intrathecal morphine versus intravenous opioid administration to impact postoperative analgesia in hepato-pancreatic surgery: a randomized controlled trial. (ovid.com)
  • Doctors should cease using Octagam intravenous immunoglobulin solutions immediately, and switch their patients to the most appropriate alternative treatment. (tga.gov.au)
  • Patients and health care providers should report any adverse events that have occurred following administration of Octagam intravenous immunoglobulin solution to the TGA via the Adverse Medicine Events Line (1300 134 237), online via ' Report a problem with a medicine ', or using the 'Blue Card' Prepaid Reporting Form . (tga.gov.au)
  • In case of acute oedema in patients suffering from HAE, the intravenous administration of C1-INH concentrate (e.g. (clinicaltrials.gov)
  • On December 23, 2014, the New York State Department of Health (NYSDOH) was notified of adverse health events in two patients who had been inadvertently administered nonsterile, simulation 0.9% sodium chloride intravenous (IV) fluids at an urgent care facility. (cdc.gov)
  • NYSDOH issued a state health advisory and posted a report on CDC's Epidemic Information Exchange (Epi-X) to inform public health personnel and medical providers of the potential for inadvertent administration of this product to patients. (cdc.gov)
  • Simultaneously, the Food and Drug Administration issued an alert, warning health care professionals not to use any Wallcur simulation IV products in human or animal patients. (cdc.gov)
  • Ten health care facilities from nine states might have administered the simulation 0.9% saline product to 45 patients (i.e., simulation saline was either administered or reported to be in the facility at the time of saline administration), although the total number of patients nationwide receiving the simulation product is unknown. (cdc.gov)
  • Intravenous (IV) iron is widely used to treat anemia in chronic kidney disease patients. (frontiersin.org)
  • ImmVira submitted an IND application for MVR-T3011 intravenous administration to the U.S. FDA in January 2021 and expects to recruit patients in five leading U.S. research cancer centers within the next few weeks. (biospace.com)
  • The updated product label provides data and information to help physicians understand the different administration options and determine which route of administration is most appropriate for their patients. (prnewswire.co.uk)
  • The intravenous administration trial was conducted at 10 centers in the U.S. and recruited a total of 30 patients, of which 24 patients were evaluable for the primary endpoint, which was the proportion of patients having an asparaginase activity level of greater than 0.1 IU/mL 48 hours after dosing 1, 2 . (prnewswire.co.uk)
  • Although described in MI patients who receive thrombolytic therapy, this complication is not well known in ischemic stroke patients who receive intravenous (IV) t-PA. (biomedsearch.com)
  • Many patients with HIV infection need intravenous (IV) therapy at some point in the course of their treatment. (ucsf.edu)
  • Although nimodipine (NM) is widely used to treat cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage, trials exploring its antihypertensive effect after intravenous administration in subjects with intracerebral hemorrhage (ICH) are scarce. (dovepress.com)
  • Since intravenous (IV) nicardipine (NC) is feasible and safe to treat hypertension in neurological patients with unfavorable outcome, it is recommended as a first-line agent in neurological intensive care unit (NICU) settings in the United States. (dovepress.com)
  • Methods: An intravenous HD-MTX solution (10 g/m [sup]2 ) was given 274 times to 148 osteosarcoma patients. (thefreelibrary.com)
  • Methods and Results- A total of 534 ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention with thrombus aspiration within 12 hours of symptom onset were randomized to either an intracoronary or an intravenous bolus of abciximab (0.25 mg/kg). (ahajournals.org)
  • Conclusions- In ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention with thrombus aspiration, intracoronary administration of abciximab compared with intravenous administration does not improve myocardial reperfusion as assessed by ST-segment resolution. (ahajournals.org)
  • 5 , - , 9 In large randomized trials, intravenous administration of the GP IIb/IIIa inhibitor abciximab during primary PCI reduced short- and long-term mortality and reinfarction rates in patients with STEMI. (ahajournals.org)
  • Although small- to medium-scale registries and randomized clinical trials have suggested beneficial clinical effects of intracoronary administration, 12 this has not been investigated in a medium-scale randomized clinical trial with an adequate number of patients to assess myocardial reperfusion. (ahajournals.org)
  • Patients with coronary artery disease undergoing PCI were stratified according to acute coronary syndrome (ACS) (n = 108) or non-ACS (n = 300), and randomized to treatment with 6 mg intravenous nicorandil (n = 206, 47 with ACS and 159 with non-ACS) or placebo (n = 202, 61 with ACS and 141 with non-ACS) prior to stent placement. (acc.org)
  • The authors concluded that among patients with suspected ACS, out-of-hospital administration of intravenous GIK, compared with glucose placebo, did not reduce progression to MI. (acc.org)
  • In this placebo-controlled, double-blind, randomized, clinical effectiveness trial of EMS administration of GIK among patients with suspected ACS, out-of-hospital administration of intravenous GIK by paramedics, compared with administration of glucose placebo, did not reduce progression to MI. (acc.org)
  • CONCLUSIONS: In this small pilot study, intermittent administration of levosimendan to ambulatory patients with advanced systolic heart failure reduced plasma concentrations of NT-proBNP, worsening of HRQoL and hospitalisation for heart failure. (ivteam.com)
  • We conclude that emergency STA-MCA bypass is a viable option for patients with moyamoya disease even after administration of rt-PA. (curehunter.com)
  • We provide targeted screening questions that can help to identify high-risk pediatric patients for both iodine-based and gadolinium-based intravenous contrast media administration. (springermedizin.de)
  • In patients suffering from malnutrition or malabsorption, intravenous ascorbic acid can be used to treat deficiency. (wikipedia.org)
  • Although the pharmacology of ascorbic acid had been studied since its discovery in the 1930s, the method of administration and its medicinal potential to human patients was not investigated until the 1940s. (wikipedia.org)
  • Over the course of the 1970s, Pauling would begin a long-term collaboration with fellow physician, Ewan Cameron, on the medical potential of intravenous ascorbate acid as cancer therapy in terminally ill patients. (wikipedia.org)
  • Intravenous iron infusions are used to treat patients with iron deficiency, iron-deficiency anaemia and chronic kidney disease. (wikipedia.org)
  • The Therapeutic Goods Administration (TGA) advises that Octapharma Australia Pty Ltd has agreed to a precautionary voluntary recall of all batches of Octagam intravenous immunoglobulin solutions from the Australian market, due to safety concerns regarding an increased incidence of thromboembolic complications associated with the use of this product in Europe and the USA. (tga.gov.au)
  • The TGA has become aware of reports of a markedly increased incidence of serious adverse reactions associated with Octagam, an intravenous immunoglobulin (IVIg) preparation, manufactured by Octapharma in Europe. (tga.gov.au)
  • Although thromboembolic events are a known rare adverse event associated with the administration of all intravenous immunoglobulin preparations, as described in the prescribing information for these products, there has recently been a steady accumulation of such events reported following administration of Octagam in Europe and the USA, with a marked increase in incidence noted during the last few months of 2010. (tga.gov.au)
  • The TGA has considered the available evidence related to the safety of this product, and with the cooperation of Octapharma Australia Pty Ltd, has agreed that as a precautionary measure, a voluntary recall of all batches of Octagam intravenous immunoglobulin solutions should be instituted in Australia, until the cause of the problem has been identified and appropriate corrective actions have been taken by the manufacturer. (tga.gov.au)
  • As a result of this decision, all stock of Octagam intravenous immunoglobulin solutions in Australia will be recalled immediately. (tga.gov.au)
  • Adequate supplies of alternative intravenous immunoglobulin solution products are available for clinical use in Australia, and it is not anticipated that this recall will lead to any shortage of supply in the foreseeable future. (tga.gov.au)
  • On February 21, 1994, the Food and Drug Administration (FDA) was notified of 14 possible cases from three different countries of acute hepatitis C among persons who had received Gammagard {Registered} *, an intravenous immunoglobulin (IGIV) product manufactured by Baxter Healthcare Corporation (Glendale, California). (cdc.gov)
  • BACKGROUND: Intravenous immunoglobulin (IVIG) is regarded as effective, theoretically, for sepsis. (minervamedica.it)
  • In 1980 a study was completed in the United States on the clinical use of intravenous iron infusions. (wikipedia.org)
  • Progressively over time intravenous iron infusions have begun to play a significantly role in the treatment of anaemia specifically in the fields of hematology and oncology. (wikipedia.org)
  • Frequency of acute kidney injury following intravenous contrast medium administration: a systematic review and meta-analysis," Radiology , vol. 267, no. 1, pp. 119-128, 2013. (hindawi.com)
  • Choe KA, Smith RC, Rosenfield AT (1995) Acute flank pain: comparison of non-contrast-enhanced CT and intravenous urography. (springer.com)
  • Cardiac rupture after intravenous t-PA administration in acute ischemic stroke. (biomedsearch.com)
  • We report a case of acute mesenteric ischemia after intravenous administration of cocaine, which extends previously reported observations (5, 6). (annals.org)
  • Acute and subacute toxicity studies on triptolide and triptolide-loaded polymeric micelles following intravenous administration in rodents. (nih.gov)
  • What is the impact of out-of-hospital emergency medical service (EMS) administration of glucose-insulin-potassium (GIK) in the first hours of suspected acute coronary syndromes (ACS)? (acc.org)
  • This is the first report of emergency STA-MCA bypass performed after intravenous rt-PA administration for acute cerebral ischemia in a patient with moyamoya disease . (curehunter.com)
  • As a result, propacetamol, an intravenous, water-soluble prodrug of acetaminophen with a well-established analgesic efficacy and safety profile, has been widely prescribed in Europe for the management of acute pain for the past 20 yr. (asahq.org)
  • The LION-HEART study was a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial evaluating the efficacy and safety of intravenous administration of intermittent doses of levosimendan in outpatients with advanced chronic heart failure" Comín-Colet et al (2018). (ivteam.com)
  • Following oral administration in fed cats, lotilaner was readily absorbed and peak blood concentrations reached within four hours. (springer.com)
  • Following oral administration to fed dogs, lotilaner displayed a terminal half-life (T 1/2z ) of 30.7 days and maximum blood concentrations were reached within two hours. (springer.com)
  • It has been suggested that intravenous ganciclovir or foscarnet maintenance therapy of CMV retinitis may result in subtherapeutic intraocular concentrations, a factor implicated in the progression of this disease ( 1 ). (asm.org)
  • Population pharmacokinetic modeling of LY2189102 after multiple intravenous and subcutaneous administrations. (nih.gov)
  • The aim of this study was to know the pharmacokinetic parameters of salicylic acid in New Zealand sheep after administration of multiple intravenous and oral doses of sodium salicylate (sodium salt of salicylic acid). (mdpi.com)
  • subcutaneous administration of C1-Inhibitor. (clinicaltrials.gov)
  • Subcutaneous administration is certainly a more attractive option from a logistical standpoint, as it entails less time and effort and provides a longer window between drug delivery and radiation treatment. (oncolink.org)
  • Haspedis L. Terbutaline in the treatment of preterm labor: a comparison of intravenous and subcutaneous administration. (jaoa.org)
  • In terms of safety, the three-month pre-clinical study showed that the intravenous administration of MVR-T3011 and MVR-T3855 did not cause significant adverse reactions and had clinical significance. (biospace.com)
  • Although small-scale studies have suggested beneficial effects of intracoronary over intravenous administration of abciximab, this has not been investigated in a medium-scale randomized clinical trial. (ahajournals.org)
  • 11 Therefore, a higher local drug concentration by intracoronary administration of abciximab is expected to further improve clinical outcome. (ahajournals.org)
  • Intravenous delivery remains the dominant paradigm in oncology, but even with precision medicine few drugs pass late stage clinical trials. (ttp.com)
  • Results support sc administration of ALT-803 in clinical studies. (ovid.com)
  • Administration of intravenous contrast media to children is a routine practice at many clinical imaging centers, that can involve special considerations. (springermedizin.de)
  • After confirming with family members that there were no contraindications, fibrinolytic treatment with intravenous rt-PA was started 2 hours and 45 minutes after symptom onset. (elsevier.es)
  • In the preclinical study conducted by ImmVira, intravenous administration of MVR-T3011 demonstrated enrichment of viral DNA in tumor tissue. (biospace.com)
  • Protein levels of type-I and type-III collagens, matrix metalloproteinase-2, and the tissue inhibitor of metalloproteinase-2 were upregulated after intravenous exposure to c-SWNTs as determined by immunohistochemical assays and Western blotting, which suggested collagen deposition and remodeling of the extracellular matrix. (dovepress.com)
  • Strategies are, therefore, needed to selectively amplify the expression of viral vectors in tumor tissue following i.v. administration. (aacrjournals.org)
  • The elimination, after intraduodenal or intravenous administration of purified tissue kallikrein radiolabelled with 125I, was followed by collecting serial samples of plasma, urine and faeces from three volunteers. (lu.se)
  • Moreover, the effectiveness of a targeted administration route is heavily influenced by the device-specific delivery parameters, such as fluid pressures and flow rates, and therefore requires multidisciplinary understanding of tissue biomechanics and anatomic and fluidic principles to complement medical device design and development. (ttp.com)
  • Due to the difficulties in obtaining tissue samples from humans, we used a rabbit model for evaluating the retinal and brain penetration of foscarnet after its intravenous administration. (asm.org)
  • Retina, vitreous humor, brain, and CSF samples were obtained at 30 and 90 min and 60 and 120 min, so that each animal yielded tissue data for two different time points, before being euthanatized with intravenous pentobarbital. (asm.org)
  • However, in individuals with hemochromatosis (a genetic disorder where the body takes up and stores too much iron), intravenous ascorbic acid is contraindicated as high dosages of ascorbic acid may result in iron overloading and therefore, lead to life-threatening complications such as heart disease, diabetes, or tissue damage. (wikipedia.org)
  • The FDA approval was based on a pharmacokinetic study of intravenous asparaginase Erwinia chrysanthemi following hypersensitivity to E coli -derived asparaginase. (prnewswire.co.uk)
  • Twenty-six adult cats were enrolled in a pharmacokinetic study evaluating either intravenous or oral administration of lotilaner. (springer.com)
  • An intravenous administration set assembly (10) is disclosed which is capable of introducing fluid from a plurality of sources of intravenous fluids into a patient and which allows the various sources of fluid to be easily attached and detected from the assembly without the necessity for intravening. (google.com.au)
  • An intravenous administration set assembly (10) is disclosed which is capable of introducing fluid from a plurality of sources of intravenous fluids into a patient and which allows the various sources of fluid to be easily attached and detected from the assembly without the necessity for intravening safety steps, such as purging the system, and yet without any possibility of air or bacteria being introduced through the system into the patient. (google.com.au)
  • The electrolyte dynamics of the inner ear fluids were compared after these two routes of administration. (unboundmedicine.com)
  • Intravenous fluids are frequently used in paediatrics but have been associated with significant adverse outcomes. (ivteam.com)
  • A method of preparing gamma globulin suitable for intravenous administration comprising a first step of treating a supernatant liquid separated from human blood plasma with ethanol under conditions of a pH of 5.5 to 6.5, an ethanol concentration of 30 to 35%, and a protein concentration of 1 to 2% by. (google.com)
  • CHAPEL HILL, N.C. , May 7, 2011 /PRNewswire/ -- Cempra Pharmaceuticals, a developer of differentiated antibiotics, today announced an oral presentation showing that intravenous (IV) solithromycin demonstrates excellent tolerability and a favorable pharmacokinetic (PK) profile at IV doses up to 800 mg. (prnewswire.com)
  • Oral administration of solithromycin also showed excellent tolerability in previously reported Phase 1 studies. (prnewswire.com)
  • Intravenous exposure was 1.3 to three fold higher than that observed with equivalent oral doses. (prnewswire.com)
  • This drug could be the first macrolide since azithromycin to offer both oral and intravenous forms of administration. (prnewswire.com)
  • Results of the study suggest that the half-life of the drug was shorter and clearance was faster after intravenous administration as compared to that of the oral administration. (mdpi.com)
  • However, oral administration of these doses failed to achieve the minimum effective concentration as mentioned above. (mdpi.com)
  • Blood samples were collected at 0, 15, 30 min and 1, 2, 4 and 6 h after IV and oral SS administrations. (mdpi.com)
  • The invention is a method of treatment of the symptoms related to inflammation that accompanies the release of Tumor Necrosis Factor-alpha in diseases such as viral infection such as those affecting the respiratory tract by providing systemic glutathione (reduced) by oral administration of glutathione (reduced) in a liposome encapsulation or by the intravenous administration of reduced glutathione. (freepatentsonline.com)
  • The administration of a therapeutically effective amount of oral liposomal glutathione (reduced) results in improvement of symptoms of disease induced by the release of TNF-α in infectious disease states such as respiratory and other viruses. (freepatentsonline.com)
  • CSF: The Na concentration increased rapidly after both intravenous and oral administrations of glycerol and remained high until the end of the experiment. (unboundmedicine.com)
  • Scala tympani perilymph: The Na concentration increased transiently, after intravenous glycerol, while after oral administration it increased slowly and steadily. (unboundmedicine.com)
  • The K concentration increased only after oral administration. (unboundmedicine.com)
  • After oral administration the Na level increased. (unboundmedicine.com)
  • These experiments show that dehydration persists longer after oral than after intravenous administration of glycerol. (unboundmedicine.com)
  • A US study suggests that intramuscular administration of the pain control medication, flunixin meglumine is more effective that the oral route. (thepigsite.com)
  • These data strongly indicate that chitosan is usable as a novel carrier of drugs in the drug delivery system for oral and intravenous administration. (springer.com)
  • Hirano S., Seino H., Akiyama Y., Nonaka I. (1990) Chitosan: A Biocompatible Material for Oral and Intravenous Administrations. (springer.com)
  • In vivo evaluation of paclitaxel-loaded lipid nanocapsules after intravenous and oral administration on resistant tumor. (archives-ouvertes.fr)
  • Following the oral administration at a dosage of 6 mg/kg, under fed or fasted conditions, or intravenous administration of 3 mg/kg, blood samples were collected up to 35 days after treatment. (springer.com)
  • 1. The contraction and relaxation responses to the polyoxyethylated vehicles currently used for the intravenous and oral administration of cyclosporin A in allograft recipients were studied in isolated rat aorta. (portlandpress.com)
  • The bioavailability of a phase 3 tablet formulation relative to that obtained via intravenous (i.v.) administration (and of other oral formulations relative to that of the phase 3 tablet) was investigated in an open-label, randomized, four-period, crossover study with healthy subjects age 18 to 50 years. (asm.org)
  • Bioavailability (0.432-0.721) and absorption half-life (94.3-157 h) after SC administration are smaller with larger doses. (nih.gov)
  • In addition, i.v. administration might also cause toxicity because of the exposure of normal cells to virus. (aacrjournals.org)
  • This goal could be accomplished by administering methylprednisolone directly at the site of injury or by developing strategies to increase spinal cord drug exposure after intravenous administration of methylprednisolone. (asahq.org)
  • Epoprostenol sodium is the sodium salt of epoprostenol, formulated as a sterile lyophilized powder for intravenous (IV) administration. (rxlist.com)
  • The minimum effective concentration required to produce analgesia in humans (16.8 µL) was achieved in sheep for about 0.17 h in the current study after intravenous administration of 100 and 200 mg/kg body weight of sodium salicylate. (mdpi.com)
  • The provision of fat during intravenous feeding is essential, but the potentially toxic byproducts of fatty acid oxidation may have adverse metabolic consequences. (nih.gov)
  • No adverse effects were observed with flunixin meglumine administration for all routes. (thepigsite.com)
  • Intravenous administration of nicorandil prior to PCI would be safe and effective in preventing slow coronary flow (SCF) phenomenon and no-reflow, and would reduce the incidence of adverse cardiovascular events following PCI. (acc.org)
  • Additionally, we discuss practical nuances of intravenous contrast media administration to children and provide a quick-reference table of appropriate treatments with pediatric dosages for adverse contrast reactions. (springermedizin.de)
  • Does intravenous paracetamol administration affect body temperature in neonates? (bmj.com)
  • The IVIG regimen for severe infection covered by Japanese health insurance is administration of 5 g/day for three days: an extremely low dosage. (minervamedica.it)
  • Metabolism of ethanol to 1-hydroxyethyl radicals in vivo: detection with intravenous administration of alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone. (aspetjournals.org)
  • Although many in vitro studies have studied hydrogen peroxide generation by ascorbic acid, the pharmacological mechanism of intravenous ascorbic acid in vivo is still unclear. (wikipedia.org)
  • This study therefore was designed to characterize the spinal cord and plasma bioavailability of methylprednisolone after intravenous and intrathecal administration. (asahq.org)
  • Bioavailability for PO administration was 22 per cent (range: 11-44 per cent) compared to IM at 76 per cent (range: 54-92 per cent). (thepigsite.com)
  • Pairis-Garcia and co-authors explain that, compared to IM administration, lower bioavailability and C-max of the PO route suggest that the latter route is less likely to be an effective therapy. (thepigsite.com)
  • An additional goal was to identify potential barriers to the spinal cord bioavailability of methylprednisolone after intravenous administration. (asahq.org)
  • 10 Thus, we hypothesized that the poor bioavailability of methylprednisolone after intravenous administration results from active exclusion of the drug from the spinal cord by P-glycoprotein. (asahq.org)
  • To address this question, we used a transgenic mouse model that lacks two key P-glycoprotein genes ( mdr 1a and mdr 1b ) to determine the role of this transporter in limiting the spinal cord bioavailability of methylprednisolone after systemic administration. (asahq.org)
  • Karthik Chellappan proposes that early exploration of better administration routes could make all the difference. (ttp.com)
  • First, by avoiding systemic toxicity, targeted administration via alternative routes may enlarge the design space for oncologic drugs, thus leading to drug candidates with improved efficacy. (ttp.com)
  • The 'targeted' delivery approach we propose is to select targeted administration routes and delivery parameters that overcome the physiological barriers to drug transport and retention. (ttp.com)
  • An air-eliminating filter (32) is attached to a manifold formed of fittings (26) which are connected through inlet adapters (28) to the sources of intravenous fluid. (google.com.au)
  • 3. An intravenous administration set assembly as claimed in claim 2 wherein the tubing means (38, 46, 56) further includes a second fitting (40) having an inlet adapter (43) provided thereon which is capable of being locked to a source of biological fluid for introduction to a patient which may not pass through an air-eliminating filter. (google.com.au)
  • Steers were also intraruminally pulse-dosed with 5 g of Co-EDTA immediately prior to treatment administration, and rumen fluid samples were collected at 0, 2, 4, 6, 8, 12, 16, and 24 h for ruminal liquid volume and dilution rate calculations. (oregonstate.edu)
  • Understanding the composition of fluid prescribed and administering an appropriate rate is essential for safe fluid administration, along with regular monitoring" McNab (2016). (ivteam.com)
  • This should lead to a change in guidelines: isotonic fluid should now be used as the primary maintenance intravenous fluid given to the majority of children. (ivteam.com)
  • McNab, S. (2016) Intravenous maintenance fluid therapy in children. (ivteam.com)
  • Biodistribution and Systemic Effects in Mice Following Intravenous Administration of Cadmium Telluride Quantum Dot Nanoparticles. (americanelements.com)
  • However, due to the systemic nature of intravenous delivery, the design space for suitable drug candidates is constrained by the conflicting requirements of efficacy, toxicity and drug physicochemical characteristics. (ttp.com)
  • CONCLUSIONS: For sepsis treatment, single administration of 15 g IVIG for one day improved the condition and inflammation earlier than divided dosage. (minervamedica.it)
  • However, for various reasons, most virus types used in developing oncolytic viruses including HSV-1 and adenoviruses, have not been fully studied for intravenous administration preclinically and clinically. (biospace.com)
  • IV administration sends medication into the patient's bloodstream. (shopmedvet.com)
  • This could lead to clinically important consequences, such as unintended medication administration. (apsf.org)
  • Intravenous administration of sucrose contained in KOVALTRY will not affect blood glucose level. (rxlist.com)
  • These data suggest that chronic and cumulative toxicity of nanomaterials to organs with abundant capillaries should be assessed if such nanomaterials are applied via intravenous administration. (dovepress.com)
  • In this preliminary analysis of GORTEC 2000-2002, the toxicity profiles of subcutaneous and intravenous amifostine appeared relatively similar. (oncolink.org)
  • Clearly, the intra-cerebroventricular administration is not a preferred route for the treatment of a chronic disease such alcoholism. (nature.com)
  • Serum: There was no significant change in Na or K levels after either route of administration. (unboundmedicine.com)
  • Scala media endolymph: No changes in the K level occurred after either route of administration. (unboundmedicine.com)
  • The researchers conclude from their results that PO administration of flunixin meglumine is not the most effective route for mature swine when compared to IV and IM. (thepigsite.com)
  • Currently, the most widely accepted route of delivery for oncologic drugs is intravenous administration. (ttp.com)
  • Septicaemia resulting from inadvertent intravenous administration of enteral nutrient solution. (biomedsearch.com)
  • Septicaemia caused by inadvertent intravenous administration of enteral nutrition solution (ENS) is a potentially lethal complication of continuous enteral tube feeding. (biomedsearch.com)
  • The minimum plasma SA concentration (16.8 µg/mL) reported to produce analgesia in humans was achieved after IV administration of 100 and 200 mg/kg SS in sheep for about 0.17 h in this study. (mdpi.com)
  • SHENZHEN, China , April 19, 2021 /PRNewswire/ -- On April 15, 2021 , ImmVira presents the preclinical study results of MVR-T3011 via intravenous administration through publication in a virtual poster at the AACR annual meeting. (biospace.com)
  • 10 A recent study has reported that local GP IIb/IIIa receptor inhibition is higher with intracoronary administration of the GP IIb/IIIa inhibitor eptifibatide. (ahajournals.org)
  • In the present study, we characterized the behavioral pharmacological interactions between methylphenidate and nicotine in the intravenous self-administration, drug discrimination, and locomotor cross-sensitization procedures. (uky.edu)
  • The results of this study suggest that administration of intravenous nicorandil prior to PCI may reduce the incidence of SCF in both the ACS and non-ACS populations. (acc.org)
  • A Randomized, Multi-centre Cross-over Study to Evaluate Patient Preference and Health Care Professional (HCP) Satisfaction With Subcutaneous (SC) Administration of Trastuzumab in HER2-positive Early Breast Cancer (EBC). (knowcancer.com)
  • Study design, drug administration, and sampling. (asm.org)
  • Background- Administration of the glycoprotein IIb/IIIa inhibitor abciximab is an effective adjunctive treatment strategy during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. (ahajournals.org)
  • Div of Transfusion Transmitted Diseases and Div of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration. (cdc.gov)
  • DUBLIN , Dec. 20, 2014 /PRNewswire/ -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the U.S. Food and Drug Administration (FDA) approved the intravenous administration of Erwinaze® (asparaginase Erwinia chrysanthemi ). (prnewswire.co.uk)
  • Second, targeted administration also has the potential to enhance the effects of other, formulation-based targeting technologies by helping drug entities overcome the physiological barriers that hinder drug transport and retention. (ttp.com)
  • The maturity of intravenous delivery can feel reassuring amongst the many uncertainties during the early phases of drug discovery. (ttp.com)
  • Technology and software for operating room drug offer major safety improvement but will require significant practice changes, including use of bar code scanning, documentation before administration, decision support tools, standardization between OR and inpatients, and compliance with the use of the new process. (apsf.org)
  • On the way to hospital, unknown atrial fibrillation was detected, with controlled ventricular response and arterial pressure of 200/100 mm Hg, subsequently decreasing without administration of antihypertensive treatment. (elsevier.es)
  • Hence, LPS administration transiently reduced DMI in steers via physiological reactions that modulate gastrointestinal motility and satiety centers in the central nervous system, in addition to potential host-microbiome endocrine interactions that impaired ruminal hay DM and NDF degradability. (oregonstate.edu)
  • At present, common types of viruses that have been studied clinically for intravenous administration are Vaccinia virus, Coxsackie virus and Reovirus etc. (biospace.com)