Vaginal Creams, Foams, and Jellies
Medicated dosage forms for topical application in the vagina. A cream is a semisolid emulsion containing suspended or dissolved medication; a foam is a dispersion of a gas in a medicated liquid resulting in a light, frothy mass; a jelly is a colloidal semisolid mass of a water soluble medicated material, usually translucent.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.
A slightly alkaline secretion of the endocervical glands. The consistency and amount are dependent on the physiological hormone changes in the menstrual cycle. It contains the glycoprotein mucin, amino acids, sugar, enzymes, and electrolytes, with a water content up to 90%. The mucus is a useful protection against the ascent of bacteria and sperm into the uterus. (From Dictionary of Obstetrics and Gynecology, 1988)
Herpesvirus 2, Human
Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Nonoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide, formulated primarily as a component of vaginal foams and creams.
Reproductive Tract Infections
Drug Administration Schedule
Anti-Infective Agents, Local
United States Food and Drug Administration
Disease Models, Animal
Nonsusceptibility to the pathogenic effects of foreign microorganisms or antigenic substances as a result of antibody secretions of the mucous membranes. Mucosal epithelia in the gastrointestinal, respiratory, and reproductive tracts produce a form of IgA (IMMUNOGLOBULIN A, SECRETORY) that serves to protect these ports of entry into the body.
Simian immunodeficiency virus
Drug Administration Routes
Dose-Response Relationship, Drug
Simian Acquired Immunodeficiency Syndrome
Gonadotropins secreted by the pituitary or the placenta in horses. This term generally refers to the gonadotropins found in the pregnant mare serum, a rich source of equine CHORIONIC GONADOTROPIN; LUTEINIZING HORMONE; and FOLLICLE STIMULATING HORMONE. Unlike that in humans, the equine LUTEINIZING HORMONE, BETA SUBUNIT is identical to the equine choronic gonadotropin, beta. Equine gonadotropins prepared from pregnant mare serum are used in reproductive studies.
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Contraceptive Agents, Female
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Herpes Simplex Virus Vaccines
Genital Diseases, Female
Clinical Chemistry Tests
One of the Indian Ocean Islands off the southeast coast of Africa. Its capital is Antananarivo. It was formerly called the Malagasy Republic. Discovered by the Portuguese in 1500, its history has been tied predominantly to the French, becoming a French protectorate in 1882, a French colony in 1896, and a territory within the French union in 1946. The Malagasy Republic was established in the French Community in 1958 but it achieved independence in 1960. Its name was changed to Madagascar in 1975. (From Webster's New Geographical Dictionary, 1988, p714)
Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)
A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
An OOCYTE-containing structure in the cortex of the OVARY. The oocyte is enclosed by a layer of GRANULOSA CELLS providing a nourishing microenvironment (FOLLICULAR FLUID). The number and size of follicles vary depending on the age and reproductive state of the female. The growing follicles are divided into five stages: primary, secondary, tertiary, Graafian, and atretic. Follicular growth and steroidogenesis depend on the presence of GONADOTROPINS.
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.
The family Cervidae of 17 genera and 45 species occurring nearly throughout North America, South America, and Eurasia, on most associated continental islands, and in northern Africa. Wild populations of deer have been established through introduction by people in Cuba, New Guinea, Australia, New Zealand, and other places where the family does not naturally occur. They are slim, long-legged and best characterized by the presence of antlers. Their habitat is forests, swamps, brush country, deserts, and arctic tundra. They are usually good swimmers; some migrate seasonally. (Walker's Mammals of the World, 5th ed, p1362)
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.
Drug Delivery Systems
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Area Under Curve
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
Follicle Stimulating Hormone
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH, and FSH), but the beta subunit is unique and confers its biological specificity.
Rats, Inbred Strains
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)
The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Reverse Transcriptase Inhibitors
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Analysis of Variance
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Metabolic Clearance Rate
Chromatography, High Pressure Liquid
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Women's interest in vaginal microbicides. (1/486)CONTEXT: Each year, an estimated 15 million new cases of sexually transmitted diseases (STDs), including HIV, occur in the United States. Women are not only at a disadvantage because of their biological and social susceptibility, but also because of the methods that are available for prevention. METHODS: A nationally representative sample of 1,000 women aged 18-44 in the continental United States who had had sex with a man in the last 12 months were interviewed by telephone. Analyses identified levels and predictors of women's worry about STDs and interest in vaginal microbicides, as well as their preferences regarding method characteristics. Numbers of potential U.S. microbicide users were estimated. RESULTS: An estimated 21.3 million U.S. women have some potential current interest in using a microbicidal product. Depending upon product specifications and cost, as many as 6.0 million women who are worried about getting an STD would be very interested in current use of a microbicide. These women are most likely to be unmarried and not cohabiting, of low income and less education, and black or Hispanic. They also are more likely to have visited a doctor for STD symptoms or to have reduced their sexual activity because of STDs, to have a partner who had had other partners in the past year, to have no steady partner or to have ever used condoms for STD prevention. CONCLUSIONS: A significant minority of women in the United States are worried about STDs and think they would use vaginal microbicides. The development, testing and marketing of such products should be expedited. (+info)
Mucosal vaccination strategies for women. (2/486)Women were immunized orally, rectally, or vaginally with a recombinant cholera toxin B-containing vaccine to determine which of these mucosal immunization routes generate the greatest levels of antibody in the female genital tract and rectum. ELISA was used to measure concentrations of cholera toxin B-specific IgA and IgG antibody in serum and secretions before and after three immunizations. Each immunization route similarly increased specific IgG in serum and specific IgA in saliva. Only the vaginal route increased IgA antibodies in genital tract secretions and could be shown to induce a local IgG response. However, vaginal immunization failed to produce antibody in the rectum. In a similar fashion, rectal immunization elicited highest concentrations of locally derived IgA and IgG antibody in the rectum but was ineffective for generating antibody in the genital tract. The data suggest that local immunization may induce the greatest immune responses in the female genital tract and rectum of humans. (+info)
Pharmacokinetics of natural progesterone administered in the form of a vaginal tablet. (3/486)Our study was conducted to assess the pharmacokinetics of natural progesterone administered in the novel formula of an effervescent vaginal tablet. Fifty post-menopausal women, with a median age of 43.5 years (range 28-55), volunteered to participate in the research. All women discontinued their hormonal replacement therapy 1 month prior to the study. The pharmacokinetics of 50 and 100 mg of progesterone administered as a vaginal tablet were evaluated. After the initial administration of 50 mg or 100 mg, a mean serum Cmax of 20.43 +/- 8.01 nmol/l and 31.61 +/- 12.62 nmol/l (P < 0.0004) was reached at a Tmax of 6.1 +/- 2.63 and 6.4 +/- 3.35 h respectively. The terminal half-life was 13.18 +/- 1.3 and 13.7 +/- 1.05 h respectively. Continuous use of the 100-mg tablet resulted in a mean serum progesterone concentration of 26.08 +/- 13.96 nmol/l and 21.42 +/- 16.32 nmol/l after 14 and 30 days respectively. Women >40 years were found to have a significantly lower Tmax compared to younger women (P = 0.02). The continuous use of vaginal progesterone did not influence the hormonal, liver or lipid profiles evaluated. Only three (6%) women suffered from mild vaginal irritation. Natural progesterone given as a vaginal tablet is well tolerated, safe and an easily administered treatment. Even in a non-oestrogenized vagina the absorption was efficient and the 100 mg dosage resulted in adequate serum progesterone concentrations. (+info)
Estradiol with or without progesterone and ambulatory blood pressure in postmenopausal women. (4/486)The purpose of this study was to determine whether transdermal estradiol and intravaginal progesterone given in doses to mimic the premenopausal state would lower blood pressure (BP) in postmenopausal women. Fifteen healthy postmenopausal women were studied in each of 3 conditions: on placebo, after 8 weeks of transdermal estradiol 0.2 mg twice per week, and again 2 weeks after addition of intravaginal progesterone 300 mg/d. Women were studied at each point after 2 days of 100 mmol/d sodium intake. Twenty-four-hour ambulatory BP monitoring was performed, and blood was assayed for estradiol, progesterone, and hormones of the renin-angiotensin-aldosterone system (RAAS). ANOVA with pairwise comparisons was used for analysis. Urinary sodium excretion was similar at each time point. Levels of estrogen and progesterone similar to those in premenopausal women were achieved. On estradiol, nocturnal systolic BP (110+/-3 mm Hg), diastolic BP (63+/-2 mm Hg), and mean BP (77+/-2 mm Hg) fell significantly (P<0.02) compared with placebo systolic BP (116+/-2 mm Hg), diastolic BP (68+/-2 mm Hg), and mean BP (82+/-2 mm Hg). Daytime BP followed the same trend but was significantly lower only for mean BP. There was no activation of the RAAS. The addition of progesterone resulted in no further fall in BP but a significant activation of the RAAS. Thus, contrary to what is often assumed, administration of estradiol with or without progesterone not only did not raise BP but rather substantially lowered BP. This BP-lowering effect may be responsible for the lower incidence of hypertension in premenopausal than in postmenopausal women. (+info)
Does an acidic medium enhance the efficacy of vaginal misoprostol for pre-abortion cervical priming? (5/486)Absorption pharmacokinetics reveal a relationship between plasma concentrations of misoprostol and its therapeutic effect. To achieve a constant plasma profile and optimal efficacy, it is important to develop a medium that ensures complete dissolution of vaginal misoprostol tablets. Vaginal misoprostol is said to liquefy better in an acidic medium; thus, the aim of this study was to determine whether a 200 microg misoprostol tablet dissolved in acetic acid would be more efficacious than 200 microg misoprostol dissolved in water for pre-abortion cervical priming. A total of 120 healthy nulliparous women requesting legal termination of pregnancy between 6-12 weeks gestation were allocated randomly to either of the study groups. Vacuum aspiration was performed 3-4 h after insertion of the misoprostol tablet. Using Hegar's dilator, the degree of cervical dilatation before operation was measured. Of 60 women, 14 (23%) achieved a cervical dilatation of >/=8 mm when the misoprostol dose was dissolved in acetic acid; 12 (20%) achieved a similar cervical dilatation when the dose was dissolved in water. The mean cervical dilatation for the acid and water media used was 6.3 mm and 6.2 mm respectively; these differences were not statistically significant, neither were pre-operative and intra-operative blood losses statistically different between the two groups. Twenty-four (40%) and four (7%) respectively of women in whom a water medium was used experienced vaginal bleeding and abdominal pain; 20 (33%) and 0 women respectively among those in whom an acetic acid medium was used experienced vaginal bleeding and abdominal pain. These differences in side effects were not statistically significant. Our study shows that the use of acetic acid to dissolve vaginal misoprostol does not improve the efficacy in achieving successful cervical dilatation for pre-abortion cervical priming. (+info)
Persistent dominant follicle alters pattern of oviductal secretory proteins from cows at estrus. (6/486)The experimental objective was to compare synthesis of oviductal secretory proteins of dairy cows bearing a persistent dominant follicle (PDF) versus a fresh dominant follicle (FDF) at estrus. On Day 7 after synchronized estrus (Day 0), cows received an intravaginal progesterone device and injection of prostaglandin F2alpha (PGF2alpha). On Day 9, cows received an injection of a GnRH agonist (FDF group; n = 3) or received no injection (PDF group, n = 3). On Day 16, all cows received PGF2alpha, and progesterone devices were removed. At slaughter on Day 18 or Day 19, oviducts ipsilateral and contralateral to the dominant follicle were divided into infundibulum, ampulla, and isthmus regions. Explants from oviductal regions were cultured in minimal essential medium supplemented with [3H]leucine for 24 h. Two-dimensional fluorographs of proteins in conditioned media were analyzed by densitometry. Rate of incorporation of [3H]leucine into macromolecules was greater in the infundibulum, ampulla, and isthmus of FDF cows (p < 0.01). Overall, intensities of radiolabeled secretory protein (P) 2 and P13 were greater for FDF than for PDF. In the ampulla, P14 was more intense for FDF while P7 was more intense for PDF. Abundance of P1 in the isthmus was greater for PDF cows. Across regions, P5, P6, P8, P9, and P11 were more intense for PDF than for FDF in the ipsilateral side. In the contralateral side, P19 was more intense for PDF than for FDF, whereas P6, P8, P9, and P11 were more intense for FDF. Differences in biosynthetic activity and in secreted oviductal proteins from cows bearing a PDF may contribute to the decrease in fertility associated with a PDF. (+info)
Ovulation and estrus characteristics in crossbred Brahman heifers treated with an intravaginal progesterone-releasing insert in combination with prostaglandin F2alpha and estradiol benzoate. (7/486)Crossbred Brahman heifers (n = 60) were studied to determine the effect of a 7-d intravaginal progesterone-releasing insert (INSERT) in combination with PG (Lutalyse; 25 mg i.m.) and estradiol benzoate (EB; .5 mg i.m.) on time of ovulation and estrous behavior. In Phase I, heifers at unknown stages of the estrous cycle were assigned by BW and body condition score to one of the three treatments on d 0: 1) INSERT for 7 d and PG on d 7 (CONTROL; n = 10); 2) INSERT for 7 d, PG on d 7, and EB 24 h after INSERT removal (EB24; n = 10); or 3) INSERT for 7 d, PG on d 7, and EB 48 h after INSERT removal (EB48; n = 10). Blood samples were collected every 8 h after INSERT removal. Also, blood sampling and ultrasonography began 8 h after the onset of estrus, determined with HeatWatch devices, and every 4 h thereafter to detect ovulation. In Phase II, Phase-I treatments (n = 10/treatments) were replicated, but only behavioral estrus data were collected to minimize handling of heifers. Frequent handling of heifers did not influence (P > .1) the interval from INSERT removal to the onset of HeatWatch and visual estrus and duration of estrus, so behavioral estrus data were combined for Phases I and II. Interval from INSERT removal to HeatWatch estrus was decreased (P < .05) in EB24 (45.5 h) vs EB48 (55.9 h) and CONTROL (59.2 h). Interval from INSERT removal to ovulation differed (P < .04) between CONTROL, EB24, and EB48 (93.5, 74.5, and 78.9 h, respectively). Ovulatory follicle size was similar (P > .1) between CONTROL, EB24, and EB48 (14.4, 12.5, and 14.1 mm, respectively). Duration of estrus was similar for CONTROL, EB24, and EB48 (14.0, 15.1, and 17.6 h, respectively). No difference (P > . 1) was observed in number of mounts received between CONTROL, EB24, and EB48 (28.0, 25.7, and 39.4, respectively), but number of mounts received increased in Phase II vs Phase I (40.0 and 22.2, respectively; P < .05). In conclusion, EB hastened the interval from INSERT removal to ovulation without altering duration of estrus or number of mounts received. Frequent handling of heifers did not affect interval to first mount received after INSERT removal or duration of estrus, but it decreased the total number of mounts received. (+info)
Luteal support with micronized progesterone following in-vitro fertilization using a down-regulation protocol with gonadotrophin-releasing hormone agonist: a comparative study between vaginal and oral administration. (8/486)This study aimed to compare the efficacy of micronized progesterone administered as luteal support following ovulation induction for in-vitro fertilization (IVF)- embryo transfer in cycles using gonadotrophin-releasing hormone agonist, either orally (200 mgx4/day) or vaginally (100 mgx2/day) and to characterize the luteal phase hormonal profile during such treatments. A total of 64 high responder patients requiring intracytoplasmic sperm injection due to male factor infertility were prospectively randomized into two treatment groups. Patients treated orally or vaginally were comparable in age (31.9 +/- 6.1 versus 30.6 +/- 5.2; mean +/- SD), number of oocytes retrieved (17 +/- 8.2 versus 18 +/- 7.0), and number of embryos transferred (3.1 +/- 1.2 versus 2.7 +/- 0.9) per cycle. Following low dose vaginal treatment, a significantly higher implantation rate (30.7 versus 10.7%, P < 0.01), but similar clinical pregnancy rate (47.0 versus 33.3%) and ongoing pregnancy rate (41.1 versus 20.0%) was observed, compared with oral treatment. In conception cycles, luteal serum progesterone and oestrogen concentrations did not differ between the treatment groups. In non-conception cycles, late luteal progesterone concentrations were significantly lower following vaginal treatment. As low dose micronized progesterone administered vaginally is simple, easy and well tolerated, it could be recommended as the method of choice for luteal support, especially for high responder patients at risk for ovarian hyperstimulation syndrome. (+info)
Impact of level of researcher support on coital diary results and acceptability among women at high risk of HIV in the...
Impact of level of researcher support on coital diary results and acceptability among women at high risk of HIV in the microbicides development programme feasibility study in Mwanza, Tanzania ...
Novel Intravaginal Ring may Help Prevent HIV
A new intravaginal ring enables the long-lasting vaginal delivery of tenofovir (TFV) shows to be effective in HIV prevention, say scientists.
A Safety and Acceptability Study of a Vaginal Ring Microbicide Delivery Method - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
An exploratory, randomized, crossover MRI study of microbicide delivery with the SILCS diaphragm compared to a vaginal...
The Penn Medicine Womens Health Clinical Research Center is a division of the Department of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania. This Center is a non-profit organization designed to assist investigators in conducting high quality patient oriented research in womens health. ...
Pre-Clinical Evaluation of mAb Microbicide Products in Nonhuman Primates - Francois Villinger
In the absence of an efficient vaccine, prevention of HIV transmission remains the primary and economically feasible infection prevention method available to da...
Safety and Acceptability of a Vaginal Microbicide - Full Text View - ClinicalTrials.gov
While the male condom is effective in preventing sexual transmission of HIV, its use is hampered by deeply rooted cultural and social barriers. About half of all HIV infections worldwide occur in women, yet the only available female-controlled method of HIV prevention is the female condom. Alternative prevention tools, such as vaginal microbicides, are urgently needed to slow the rapid spread of heterosexual HIV infection.. This study will last 24 weeks, with an additional 10 weeks of follow-up for participants with chronic hepatitis B virus (HBV) infection. Participants will be randomly assigned to one of four arms. Arm A participants will insert a vaginal tenofovir 1% gel two hours prior to vaginal intercourse for a maximum of two daily applications. Arm B participants will insert a vaginal placebo gel two hours prior to vaginal intercourse for a maximum of two daily applications. Arm C participants will insert a vaginal tenofovir 1% gel once daily at bedtime or during the longest period of ...
In todays research we investigate the impact of a variety of - PI3K Signaling in B and T Lymphocytes
In todays research we investigate the impact of a variety of TLR ligands and chitosan as potential adjuvants for different routes of mucosal immunisation (sublingual (SL), intranasal (IN), intravaginal (IVag) and a parenteral route (subcutaneous (SC)) in the murine model. to antigen by itself SL>IN?=?SC. A genuine variety of adjuvants elevated particular systemic IgA replies where generally IN>SL>SC immunisation, while for mucosal replies IN?=?SL>SC. On the other hand, immediate intravaginal immunisation didnt induce any detectable systemic or mucosal replies to gp140 also in the current presence of adjuvant. Nevertheless, significant systemic IgG replies to TT had been induced by intravaginal immunisation with or without adjuvant, and detectable mucosal responses IgA and IgG had been observed when TT was administered with FSL-1 or Poly IC. Oddly enough some TLRs shown differential activity influenced by the path of administration. MPLA (TLR4) suppressed systemic replies to SL immunisation ...
Microbicides | AIDSFree
Introduction Definition of the Prevention Area Microbicides are products formulated for individuals to apply topically (vaginally or rectally) to reduce their risk of HIV and possibly other sexually transmitted infections. At present, this approach is experimental, although several broad-spectrum microbicides have been clinically evaluated. Microbicides comprise a subset of approaches to pre-exposure prophylaxis (PrEP); oral approaches to PrEP are addressed in a separate entry. Epidemiological Justification for the Prevention Area In generalized epidemics, women are at a disproportionate risk of HIV infection for biological as well as social reasons. Although condoms are highly effective in preventing HIV transmission, it can be difficult for women to negotiate safer sex because the male partner often controls whether a condom is used. Microbicides were initially proposed as a woman-controlled or -initiated prevention method for vaginal application, something a woman could use to protect herself. The
cattle99pg65-67 by G.C. Lamb, J.A. Cartmill et al.
The Cosynch protocol (GnRH 7 days before and again 48 h after PGF2 with AI at the second GnRH injection) produced pregnancy rates in suckled beef cows that exceeded 50% without heat detection and with only three handlings of all cows. The addition of an intravaginal progesterone insert to the Cosynch protocol improved pregnancy rates in two of the three breeds of cows studied.
Femring, Ask a Doctor about uses, dosages and side-effects of Femring - Doctors insight on HealthcareMagic
Vaginal rings (also known as intravaginal rings , or V-Rings ) are polymeric drug delivery devices designed to provide controlled release of drugs for intravaginal administration over extended...
Vaginal progesterone in women with an asymptomatic sonographic...
Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic
Image Gallery : Safety Trial of the Vaginal Microbicide Cellulose Sulfate Gel in HIV-Positive Men : Sexually Transmitted...
For prevention of HIV, genital herpes and HPV. VivaGel® is being developed as a vaginal microbicide to offer safer sex by preventing transmission of genital herpes (HSV-2), HIV and other sexually transmitted infections (STIs) including human papillomavirus (HPV), the causative agent of cervical cancer.. There is an enormous global need for a vaginal microbicide offering protection of this kind. For example:. ...
Международный медицинский журнал -| Текущий номер -| №4 2017г.
The authors report the results of evaluation of the effectiveness of extracorporeal fertilization after the transfer of vitrified blastocysts in the natural cycle and with the use of hormone replacement therapy. It was found that the most effective is the protocol, in which the transfer of vitrified blastocysts occurs in a modified natural menstrual cycle with the support of the luteal phase by intravaginal administration of 90 mg of progesterone in the form of a gel for 2 weeks ...
Flow cytometric analysis of TLR expression in rabbit CV | Open-i
Flow cytometric analysis of TLR expression in rabbit CVE cells after intravaginal administration of placebo, nisin (15.15 mM in 2 mL of 1% polycarbophil gel) SD
Microbicides in the Prevention of HIV Infection: Current Status and Future Directions. - GOV.UK
More than 28 years since the first cases of HIV/AIDS, there is still no cure or vaccine. The worst affected region is sub-Saharan Africa and, increasingly, it is young women who are bearing the brunt of the epidemic. Consequently, there is an urgent need for HIV prevention options for women in developing countries. Microbicides are topical products that can be used vaginally by women to impede sexual transmission of HIV and thus represent one of the most promising prevention strategies. Efficacy trials with early nonspecific microbicide gels have so far been unsuccessful, but the field has now switched its focus to products containing highly potent and highly specific antiretroviral drugs that are easier to use, and can be formulated in a variety of dosage forms to suit individual and regional preferences. However, these products have their own challenges, with a greater likelihood of absorption, and the potential for systemic toxicities or the development of resistance in infected individuals ...
72% of Women Are Dissatisfied With Their Current Treatment of Vaginal Infection, Su... ( Foamix Offers New Intravaginal Foam....
... Foamix Offers New Intravaginal Foam Technology with Improved Usabili... Compliance ...NESS ZIONA Israel May 13 /- Despite the high incidence...Findings show that the majority of females who have used intravaginal...,72%,of,Women,Are,Dissatisfied,With,Their,Current,Treatment,of,Vaginal,Infection,,Survey,Finds,biological,advanced biology technology,biology laboratory technology,biology device technology,latest biology technology
Akademik Bilgiler | akademik.ege.edu.tr
Baloglu E., Şenyiğit Ay Z., Karavana S. Y., Vetter A., Metin D. Y., Hilmioğlu Polat S., Güneri T., Bernkop-Schnurch A., In Vitro Evaluation of Mucoadhesive Vaginal Tablets of Antifungal Drugs Prepared with Thiolated Polymer and Development of a New Dissolution Technique for Vaginal Formulations, Chem. Pharm. Bull. 59, 952-958 (2011 ...
Is it safe to administer progesterone vaginally? | RAXA
My 26 years old wife is 161 cm tall and weighs 56 kg. She has been diagnosed with PCOD. The gynaecologist asked her to take Nacfil 600 twice a day for three months and last month she was prescribed Siphene 50 for ovulation. My wife is pregnant now and her doctor has asked her to take folic acid and progestone 100 by vaginal administration. But I have read that progestone vaginal administration is not advisable for patients having cystic problems. Please tell whether or not is my wife on right treatment ...
Systemic CD4+ T Cell Loss Resulting from Intravaginal H | Open-i
Systemic CD4+ T Cell Loss Resulting from Intravaginal HIV-1 Infection in Humanized BLT Mice(A) Comparison of the levels of CD4+ or CD8+ human T cells in the ind
Correspondence] Vaginal progesterone prophylaxis for preterm birth - Authors reply - doctorportal | doctorportal
We thank Dimitrios Papoutsis and Angeliki Antonakou and John OBrien for their comments on our OPPTIMUM trial.1 We are somewhat surprised that Papoutsis and Antonakou describe the editorial accompanying OPPTIMUM as expressing scepticism-that was not our interpretation.2 However, we agree that further subgroup analyses might be helpful.. ...
Progestrone inserts | Bub Hub
Hi I was just put on progesterone inserts as I had a miscarriage a few months ago and have found out I am expecting again... could you please help me in letting me know if this made anyone sick or had awful side effects?
Cytotec Vaginally. 100% Satisfaction Guaranteed, Without Visiting a Doctors office - Absolutely Safe Order, Lowest Prices and Free Worldwide Delivery.
Vaginal Microbicide Gel New NNRTI for Delivery of IQP-0528, a Pyrimidinedione Analog with a Dual Mechanism of Action against...
The field of rectal and vaginal microbicides is a new therapeutic area with several candidates in clinical trials and no registered products. Many of these candidates, with the exception of a 1% tenofovir gel evaluated in the recent CAPRISA 004 trial (1), have failed to demonstrate safety or efficacy. Despite these setbacks, the field is still progressing rapidly due to the pressing need for prophylactic technologies and the advantages of vaginal route of delivery for antiretroviral drugs (9, 16). Typically, drugs delivered through the vaginal route encounter an acidic environment with pH ranging from 4.0 to 5.0 (37, 40). However, soon after intercourse, the vaginal pH increases to a neutral pH due to the introduction of semen. The vaginal environment also hosts several Lactobacillus strains that constantly generate lactic acid and hydrogen peroxide, maintaining an acidic pH in the vaginal cavity (37, 40). Therefore, successful development of a vaginal microbicide product requires an active ...
Human Trial of Vaginal Microbicide Gel PRO 2000 Finds Some Level of HIV Protection - TheBody.com
Human Trial of Vaginal Microbicide Gel PRO 2000 Finds Some Level of HIV Protection, at TheBody.com, the complete HIV/AIDS resource.
A New Procedure to Synchronize Estrus in Dairy Heifers: Progesterone Inserts and PGF2a - Dairy Cattle
Use of the intravaginal progesterone insert (CIDR) along with PGF2a effectively synchronizes estrus in dairy heifers. It is expected to be available in 2001; however, approval for use in lactating cows is not being sought at this time. Approval for use is lactating cows is expected to be sought after approval is acquired for its use in heifers. During 2001 there will be procedures to synchronize estrus in dairy heifers: PGF2a, MGA and PGF2a (discussed in another article within this publication), and the concurrent use of CIDRs and PGF2a. Producers should obtain the advantages of AI and reduce the reliance on estrus detection as heifers are an easy to bred female.. ...
Computational Molecular Design of Cellulose-based Delivery Vehicles for Vaginal Microbicide Gels
HIV/AIDS is a global pandemic that has claimed the lives of 39 million people and currently afflicts 36.9 million more. These effects are disproportionately felt in sub-Saharan Africa which has almost 70% of those current cases and where women account for 59% of current infections. These numbers are even more disproportionate for young women and complications associated with HIV/AIDS are the leading cause of death in women aged 15-44. This creates a need for female-controlled tools to prevent infection. Microbicides are one such tool. Microbicides are vaginally-delivered topical products that combine a therapeutic agent with activity against HIV and a delivery vehicle. The delivery vehicle can consist of many different formulations, depending on the therapeutic agent used and the delivery mechanism desired. Polymer solutions (known as gels in the microbicide field) have received the most attention and have been incorporated into the most formulations for use in clinical trial evaluations. ...
Comparison of two intravaginal progesterone releasing devices in lactating dairy cows: blood progesterone profile and field...
Comparison of two intravaginal progesterone releasing devices in lactating dairy cows: blood progesterone profile and field fertility. ...
Sublingual versus intravaginal misoprostol for treatment of missed abortion a double blind study for Ziena Heba Hamid Morsy
Thesis, English, Sublingual versus intravaginal misoprostol for treatment of missed abortion a double blind study for Ziena Heba Hamid Morsy
Studies on the use of the CIDR intravaginal device for reproductive management of dairy cattle : a thesis presented in partial...
This study was undertaken as a series of projects which involved selected studies with the CIDR Controlled internal drug releasing device (Eazi-Breed CIDRtm-B, Carter Holt Harvey Plastic Products, Hamilton, N.Z. intravaginal device in dairy cattle. In the first project, a CIDR device was inserted at different stages of the oestrous cycle to characterize the dynamic changes of the follicles in the ovaries of cycling cows, the associated changes in plasma progesterone concentrations (PPC), and the effects of progesterone from the device on cycle lengths. The results demonstrated that the progesterone released by the CIDR appeared to enhance the development and maintenance of a dominant follicle. The reproductive responses after device removal were influenced by the follicular population, and by the stage of the follicular wave even in the absence of a corpus luteum (CL) The PPCs during CIDR insertion or after removal were influenced by the type of animal and the stage of the cycle when treatment ...
AIDS 2010 Update: Results of CAPRISA Microbicide Gel Trial: An exciting HIV Prevention Tool for Women | Management Sciences for...
On July 19, here in Vienna at the XVIIIth International AIDS Conference, positive results were announced from the CAPRISA 004 Phase IIb microbicide trial of 1% tenofovir gel, which was tested in 889 South African women. Overall, there were 39 percent fewer infections among women who received the gel compared to women who received the placebo -and the results showed 51% efficacy of the gel against transmission of herpes simplex virusto women. Of note, recent vaccine trials and microbicide trials have set as a limit of efficacy 30% in order to be considered effective, which generally means that the FDA will approve them. This, of course, is great news and a real breakthrough. There have been several previous trials of vaginal microbicides which have not shown any efficacy. Its also great because its potentially female controlled, i.e., women can conceivably insert it vaginally and be protected if their husbands/partners force sex upon them. In addition, this could be a great intervention for ...
Changing dose of progesterone results in sudden changes in frequency of luteinizing hormone pulses and secretion of 17β...
TY - JOUR. T1 - Changing dose of progesterone results in sudden changes in frequency of luteinizing hormone pulses and secretion of 17β-estradiol in bovine females. AU - Bergfeld, E. G.M.. AU - Kojima, F. N.. AU - Cupp, A. S.. AU - Wehrman, M. E.. AU - Peters, K. E.. AU - Mariscal, V.. AU - Sanchez, T.. AU - Kinder, J. E.. PY - 1996/3/1. Y1 - 1996/3/1. N2 - The aim of the present study was to elucidate the time course according to which changes in circulating concentrations of progesterone influence pulsatile secretion of LH and secretion of 17β-estradiol. Our working hypothesis was that changing the dose of progesterone would result in changes in frequency of LH pulses and secretion of 17β-estradiol within 72 h. Five days after behavioral estrus, thirty-three cows were randomly assigned to one of five groups: 1) control, no treatment (CONT, n = 5); 2) treatment with two progesterone-releasing intravaginal devices (PRIDs) for 11 days (2PRID, 5-6 ng/ml plasma progesterone, n = 7); 3) treatment ...
Microbicide gel fails to work in large international trial | aidsmap
But VOICE has now produced a negative result and the licensing of a vaginal microbicide has become a considerably more distant prospect, as approval may now depend on more than one future positive result.. Future plans. Other trials are nonetheless proceeding, as researchers dont yet know why no efficacy was found in VOICE and no safety issues were raised by the gel. The FACTS 001 trial is a South African study of tenofovir microbicide gel using the same before-and-after-sex regimen as CAPRISA 004. In has just started to enrol a planned 2,200 women at nine sites. In the middle of next year, the ASPIRE trial, a long-awaited efficacy trial of a vaginal ring impregnated with another anti-HIV drug, dapivirine (TMC120), will start: it is hoped that the ring, which will sit on the cervix and be renewed monthly, will overcome the adherence problems that have been the bane of HIV prevention trials using antiretroviral drugs. And of course the Truvada term will continue in VOICE and may represent, as ...
Dairy89pg11-13 by Jeffrey S. Stevenson
Research in reproductive physiology and breeding management of dairy cattle at Kansas State University has the following objectives: 1) to better understand those factors that influence the reestablishment of ovarian function, estrous cycles, and fertility after calving and 2) to apply that knowledge to areas of management in which pregnancy rates and calving intervals can be improved in dairy herds. Our past efforts have included 1) pioneering research into the applications of gonadotropin-releasing hormone (GnRH) at the time of insemination and early postpartum as a prophylactic treatment for inducing estrous cyclicity; 2) application of treatments utilizing prostaglandin F2α(PGF2α) for breeding management of open cows, estrous induction for first services, and postpartum therapy for cows with periparturient problems; 3) utilization of progesterone-releasing intravaginal devices (PRIDs) to induce estrus and enhance fertility; 4) studies aimed at understanding estrous behavior, including the
Microbicide Gel Shows Reduced Risk of HIV and Herpes Infection in Women | MHRP | Military HIV Research Program
The MHRP applauds results announced today that the Center for the AIDS Program of Research in South Africa (CAPRISA) 004 trial showed that a vaginal microbicide gel could safely and effectively reduce the risk of heterosexual transmission of HIV from men to vulnerable women. The microbicide containing 1% tenofovir-an antiretroviral drug widely used in the treatment of HIV-was
Multipurpose Prevention Approaches with Antiretroviral-Based Formulations | Antimicrobial Agents and Chemotherapy
The most recent lead microbicide formulations, tenofovir (TFV) 1% gel and the dapivirine intravaginal ring (IVR), have been investigated as means to prevent primarily human immunodeficiency virus (HIV) acquisition. Recent clinical trials like CAPRISA 004 (clinical trial registration number NCT00441298) (1, 2), conducted by the Centre for the AIDS Programme of Research in South Africa, and the VOICE trial (Vaginal and Oral Interventions to Control the Epidemic; clinical trial registration number NCT00705679) (3) have investigated the effectiveness of TFV 1% gel to prevent HIV acquisition. CAPRISA 004 was a study comparing TFV 1% vaginal gel with a placebo when used before and after sex while the VOICE trial looked at daily use of an oral tablet (TFV or Truvada) or a vaginal gel (TFV 1% gel). CAPRISA 004 and the VOICE trial showed a reduction in herpes simplex virus 2 (HSV-2) acquisition that correlated with the use of TFV vaginal gel. This was surprising since TFV has modest anti-HSV activity in ...
Randomised trial of intravaginal misoprostol and intracervical Foley catheter for cervical ripening and induction of labour....
Le misoprostol est plus efficace que la sonde de Foley pour déclencher le travail sur un col non favorable. Le fait que cela augmente lincidence des hypertonies ne semble pas affecter les auteurs.
Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal...
TY - JOUR. T1 - Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard® gel. T2 - a new formulation for dual protection contraception. AU - Sitruk-Ware, Regine. AU - Brache, Vivian. AU - Maguire, Robin. AU - Croxatto, Horacio. AU - Kumar, Narender. AU - Kumar, Sushma. AU - Montero, Juan Carlos. AU - Salvatierra, Ana Maria. AU - Phillips, David. AU - Faundes, Anibal. PY - 2007/6/1. Y1 - 2007/6/1. N2 - Objective: The study was conducted to assess levonorgestrel (LNG) serum levels achieved after a single administration of two different doses of Carraguard vaginal gel containing LNG (CARRA/LNG), designed for use as microbicide and contraceptive for potential dual protection. Materials and Methods: This was a randomized double-blind pharmacokinetic study conducted in 12 subjects enrolled at two centers. Each subject received a single vaginal administration of CARRA/LNG containing either ...
Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice. | Physicians...
Approximately 40% of HIV-1 infections occur in the female genital tract (FGT), primarily through heterosexual transmission. FGT factors determining outcome of HIV-1 exposure are incompletely understood, limiting prevention strategies. Here, humanized NOD-Rag1(-/-) γc(-/-) mice differentially reconstituted with human CD34+ -enriched hematopoietic stem cells (Hu-mice), were used to assess target cell frequency and viral inoculation dose as determinants of HIV-1 infection following intravaginal (IVAG) challenge. Results revealed a significant correlation between HIV-1 susceptibility and hCD45+ target cells in the blood, which correlated with presence of target cells in the FGT, in the absence of local inflammation. HIV-1 plasma load was associated with viral dose at inoculation and frequency of target cells. Events following IVAG HIV-1 infection; viral dissemination and CD4 depletion, were not affected by these parameters. Following IVAG inoculation, HIV-1 titres peaked, then declined in vaginal ...
Polymeric gels for intravaginal drug delivery - pharma excipients
Abstract Intravaginal drug delivery can elicit a local effect, or deliver drugs systemically without hepatic first pass metabolism. There are a number of emerging areas in intravaginal drug delivery, but the vagina is a challenging route of administration, due to the clearance mechanisms present which result in poor retention of dosage forms, and the potential for irritation and other adverse reactions. Gel formulations are desirable due to the ease of application, spreading and that they cause little to no discomfort to the patient. However, these dosage forms, in particular, are poorly retained and traditional gels typically have little control over drug release rates. This has led to a large number of studies on improving the retention of vaginal gels and modulating the controlled release of drugs from the gel matrix. This review outlines the anatomy and physiology of the vagina, focussing on areas relevant to drug delivery. Medical applications of vaginally administered medicines is then ...
Experimental NNRTI-Based Microbicide Gel Prevents HIV Infection in Monkeys - TheBody.com
An experimental vaginal microbicide applied daily protected female monkeys against simian HIV (SHIV) infection, even hours after application, according to ...
Dapivirine | TMC120 | CAS#244767-67-7 | HIV-1 replication inhibitor | MedKoo
Dapivirine, also known as TMC120, is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM. The HIV-1 replication inhibitor dapivirine (DPV) is one of the most promising drug candidates being used in topical microbicide products for prevention of HIV-1 sexual transmission. [last updated: 10/9/2015)
Wholesale Vaginal Gel ☆ Find 48 vaginal gel products from 33 manufacturers & suppliers at EC21. ☆ Choose quality vaginal gel manufacturers, suppliers & exporters now - EC21
Flexible, Compressed Intravaginal Rings, Methods of Making and Using the Same, and Apparatus for Making the Same - Patent...
0119] Not being bound by any particular theory, the process of the present invention can be optimized based on the plastic and elastic properties of the mixture. The plastic and elastic properties of the mixture are substantially inversely related to one another. Thus, as the plasticity of a mixture increases, its elasticity decreases. During compression, the plasticity of the substantially homogeneous mixture permits the mixture to retain the shape that is formed by compressing the mixture. Generally, the plasticity of a mixture increases as the temperature of the mixture is increased, and in particular, the plasticity can increase rapidly above the Tg of a mixture. Thus, one of ordinary skill in the art of compression would expect that a more efficient compression process would occur at a temperature above the Tg of a plastic mixture. However, the process of the present invention compresses a mixture at a temperature below the Tg of the mixture. While controlling the temperature in this manner ...
We have recently reported that the intravaginal instillation of synthetic Toll-like - GLO1 inhibitors for neuropsychiatric
We have recently reported that the intravaginal instillation of synthetic Toll-like receptor 3 (TLR3) or TLR9 agonists after a subcutaneous vaccination against human papillomavirus E7 highly increases (~5-fold) the number of vaccine-specific CD8+ T cells in the genital mucosa of Dabigatran mice without affecting E7-specific systemic responses. via bacterial components including lipopolysaccharide (LPS a TLR4 agonist) 5 flagellin (a TLR5 agonist)6 and/or bacterial DNA (TLR9 agonist) not only when delivered orally (their normal route of infection) but also when administered in vagina.7 In addition attenuated can be easily engineered to deliver heterologous antigens8 9 and is used as a vaccine (strain Ty21a 10 Vivotif?) against typhoid fever by the oral route since decades with an excellent safety record.11 Here we have investigated whether attenuated serovar Typhimurium vaccine strains would act as an IVAG immunostimulant after E7 vaccination in mice. Result and Discussion Intravaginal ...
Approaching HIV prevention with young womens preferences in mind | Nature Research Microbiology Community
To many scientists, it may seem that HIV prevention research has succeeded - large clinical trials of oral pre-exposure prophylaxis (PrEP) and vaginal formulations of antiretroviral drugs (ARVs) demonstrated that these products can indeed prevent HIV infection when used [1-3]. This is great news! But the problem we face as a global HIV prevention community is not whether or not we have efficacious products. The problem is whether or not the products will appropriately meet womens needs and lifestyles and thus whether or not women will use them. Adherence to product use is quite possibly the biggest issue blocking the eradication of sexual HIV transmission .
Estrace Vaginal Cream - Is there a generic form of this cream?
1 Answer (question resolved) - Posted in: estrace, estrace vaginal cream - Answer: No. Estrace is the only approved form of estradiol vaginal cream ...
Order Cleocin Vaginal Cream 2% 40 grams From $1.81 USD/gram - Canada
Order Cleocin Vaginal Cream 2% 40 grams online, including Cleocin Vaginal Cream 2% 40 grams, from the largest Canadian pharmacy with free shipping on all orders
Patent US20060106109 - Short term treatment for uterine disorder - Google Patents
This invention is directed to a method and device for treating a female patients uterine disorder by occluding one or both of the patients uterine artery. The treatment embodying features of the invention basically involves occluding one or both of the patients uterine arteries with an intravaginal device to form a thrombus within the occluded artery or arteries and administering an agent which will prolong the occlusion of the artery or arteries after removal of the occluding device or initiate or accelerate fibroid cell apoptosis (programmed cell death). The intravaginal device has a pair of pivotally connected occluding members, with at least one of the occluding member having a movable occluding element on a distal shaft section of the occluding member.
Flucos 0.5 % Gel - Uses, side effects, substitutes, composition & more | Practo
Flucos 0.5 % Gel is an anti-fungal drug. It is used to prevent and treat infections caused by fungi and yeasts. It acts by stopping the growth and multiplication of these organisms.Know Flucos 0.5 % Gel uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on | Practo
3D 1 % Gel - Uses, side effects, substitutes, composition & more | Practo
3D 1 % Gel is used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis etc. Know 3D 1 % Gel uses, side-effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on | Practo
Global Campaign for Microbicides : Microbicides in the Media
The Global Campaign for Microbicides advocates worldwide for user-controlled HIV and STD prevention tools; microbicides, female condoms and cervical barriers. We work to promote their development, assure access and protect users needs and interests.
Initial safety trial results find increased risk of serious heart-related problems and cancer with arthritis and ulcerative...
Listen to FDA Drug Safety Podcast on Drug Safety Communication titled Initial safety trial results find increased risk of serious heart-related problems and cancer with tofacitinib (Xeljanz, Xeljanz XR)
Long-awaited microbicide gel faces funding shortfall - SciDev.Net
<p>Scientists who developed tenofovir, the vaginal gel that could transform AIDS protection for women, are struggling to fund the final trials.</p>
Urinary incontinence- recent therapeutic developments | Nursing in Practice
Women who fail to respond to such measures and who request further, non-surgical treatment can be considered for a variety of intravaginal or intraurethral devices. The Conveen Continence Guard(TM) (Coloplast Ltd) is an example of an intravaginal device (see Figure 1). The shape of the device is such that, when it is placed in the vagina, it supports the bladder neck and thus prevents or reduces leaking during physical activity. It is inserted into the vagina with the use of an applicator (see Figure 2) and can be used for up to 16 hours per day.. [[NIP02_fig1_84]]. [[NIP02_fig2_84]]. There is no pharmacological agent currently available that has been shown to be effective in the treatment of patients with genuine stress incontinence. However, randomised placebo-controlled trails are in progress that aim to assess the efficacy of an alpha-adrenergic agonist as well as a 5-HT reuptake inhibitor for the treatment of such patients ...
Vaginal Gel Holds Promise in Preventing AIDS
An experimental vaginal gel has yielded promising results in preventing HIV infection in women, according to clinical trials conducted in Africa and the United States, the US National
Pharmacodynamics of progesterone
Bäckström T, von Schoultz B, Toivonen J (1979). "Plasma progesterone concentrations after administration via intravaginal rings ... The mean values of TT, FT, SHBG, DHEAS, A4, and 17-OHP did not change with OMP administration. However, a higher 17-OHP level ... In contrast, exogenous administration of progesterone to pregnant rodents and monkeys has resulted in minimal abnormality in ... In addition, a study found that administration of 1,000 mg/day oral progesterone for 3 months had no significant effect on ...
For vaginal delivery in pharmacology, see Intravaginal administration.. Sequence of images showing the stages of a normal ...
Intravaginal administration is preferred to taking them by mouth. Prolonged repetitive courses of treatment appear to be more ... VandeVusse L, Hanson L, Safdar N (2013). "Perinatal outcomes of prenatal probiotic and prebiotic administration: an integrative ...
"Efficacy of intravaginal and intranasal administration of micronized estradiol-17beta". J. Clin. Endocrinol. Metab. 45 (6): ... This route of administration is thus preferred in women with a history of thromboembolic disease. Estrogen is also used in the ... However, such risks have been found to vary depending on the type of estrogen and the route of administration. The risk of VTE ... It was only until 1941 when estrogen therapy was finally approved by the Food and Drug Administration (FDA) for the treatment ...
"Efficacy of intravaginal and intranasal administration of micronized estradiol-17beta". J. Clin. Endocrinol. Metab. 45 (6): ... Sublingual administration of estradiol was first described in the early 1940s. Buccal estradiol tablets were marketed by ... In addition to the route of administration, the type of estrogen influences VTE risk. Oral conjugated estrogens are associated ... "[email protected]: FDA Approved Drug Products". United States Food and Drug Administration. Retrieved 26 July 2018. Rogerio A. Lobo (5 ...
A weekly vaginal ring is an effective and safe method for intravaginal administration. Intramuscular administration. Daily ... Intravaginal administration of gel, tablets or other inserts, such as endometrin. ... The main ones are: Oral administration of progesterone or progestin pills. Oral administration of progestins provides at least ... Luteal support is the administration of medication, generally progesterone, progestins, hCG or GnRH agonists, to increase the ...
Intravaginal, endocervical or extra-amniotic administration of prostaglandin, such as dinoprostone or misoprostol. ... administration of synthetic oxytocin preparations is used to artificially induce labor if it is deemed medically necessary. A ...
... is a form of estrogen that is delivered by intravaginal administration. Vaginally administered estrogens are ... Pharmacokinetics of estradiol § Vaginal administration Estrogen (Vaginal Route) from Mayo Clinic / Thomson Healthcare Inc. ...
... in women following oral and intravaginal administration". Steroids. 26 (3): 373-386. doi:10.1016/0039-128X(75)90082-3. ISSN ... Rectal administration of MPA has also been studied. With intramuscular administration of 150 mg microcrystalline MPA in aqueous ... In another study, peak levels of MPA were 3.4 to 4.4 ng/mL within 1 to 4 hours of administration of 10 mg oral MPA using ... Subsequently, MPA levels fell to 0.3 to 0.6 ng/mL 24 hours after administration. In a third study, MPA levels were 4.2 to 4.4 ...
Controlled internal drug release
They also allow administration of a natural form of hormone, as opposed to the potent analogues used in sponges. A dose of 550 ... Previously, intravaginal progestogen sponges were a common method of estrus manipulation in ewes. The development and success ... Unlike intravaginal progestogen sponges, CIDRs do not absorb or impede drainage of natural vaginal secretions, offering a ... CIDRs are similar to the progesterone-releasing intravaginal device (PRID), also used for synchronization of estrous cycles in ...
"Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation". ... On 18 October 2007, the U.S. Food and Drug Administration (FDA) announced that a warning about possible deafness (sudden ... "Tainted Products Marketed as Dietary Supplements". United States Food and Drug Administration. Tucker J, Fischer T, Upjohn L, ... Food and Drug Administration. 2007-10-18. Retrieved 2009-08-06. Kloner RA (December 2005). "Pharmacology and drug interaction ...
July 2009). "Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ... "Food and Drug Administration. 2007-10-18. Retrieved 2009-08-06.. *^ Kloner, Robert A. (2005-12-26). "Pharmacology and drug ... "United States Food and Drug Administration.. *^ Tucker, Jenna; Fischer, Tessa; Upjohn, Laurence; Mazzera, David; Kumar, Madhur ... On 18 October 2007, the U.S. Food and Drug Administration (FDA) announced that a warning about possible deafness (sudden ...
Intravaginal preparations of fenticonazole may damage latex contraceptives and additional contraceptive measures are therefore ... necessary during local administration. The Merck Index, 12th Edition. 4047 v t e. ...
Estrogen - intravaginal administration helps to prevent pelvic muscle atrophy. SurgeryEdit. The surgery to repair the ...
Intravaginal administration is a route of administration where the medication is inserted into the vagina as a creme or tablet ... An applicator is inserted into the vagina to allow the administration of radiation as close to the site of the cancer as ... "The Benefits of Vaginal Drug Administration-Communicating Effectively With Patients: The Vagina: New Options for the ... with limited systemic adverse effects compared to other routes of administration. Medications used to ripen the cervix and ...
History and culture of substituted amphetamines
Rectal administration and intravaginal administration are less-popular drug routes in the community with comparatively little ... Drug injection via intravenous administration, intramuscular administration, or subcutaneous administration carries relatively ... This method of administration is sometimes referred to as "chasing the dragon". Crystal methamphetamine and salts of ... After decades of reported abuse, in 1965 the United States Food and Drug Administration (USFDA) banned Benzedrine inhalers,[ ...
Route of administration
Intravaginal administration, in the vagina. Intravenous (into a vein), e.g. many drugs, total parenteral nutrition. ... Oral administration is often denoted "PO" from "per os", the Latin for "by mouth". The bioavailability of oral administration ... Strictly enteral administration (directly into the intestines) can be used for systemic administration, as well as local ( ... Extra-amniotic administration, between the endometrium and fetal membranes. Nasal administration (through the nose) can be used ...
A recent meta-analysis showed that the intravaginal route with an appropriate dose and dosing frequency is equivalent to daily ... A duration of progesterone administration of 11 days results in almost the same birth rates as longer durations. Patients are ... While daily intramuscular injections of progesterone-in-oil (PIO) have been the standard route of administration, PIO ... beneficial to administer an additional drug that suppresses hormone production by the ovaries such as continuous administration ...
DPV, an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI), is slowly released via local intravaginal administration ... However, women younger than 21 years old are less likely to adhere to the intravaginal HIV microbicide regimen. From 2016 to ... A number of alternative intravaginal rings made by IPM are under further testing or in preclinical developmental delay due to ... Woolfson, A. David; Malcolm, R. Karl; Morrow, Ryan J.; Toner, Clare F.; McCullagh, Stephen D. (2006-11-15). "Intravaginal ring ...
Birth control in the United States
According to the New York Times of 6 October 2017, the Trump administration at that time moved to expand the rights of ... and intravaginal ring (NuvaRing). Progestin only methods include an injectable form (Depo-Provera), a subdermal implant ( ... In 2017, the Trump administration issued a ruling letting insurers and employers refuse to provide birth control if doing so ... Pear, Robert; Ruiz, Rebecca R.; Goodstein, Laurie (2017-10-06). "Trump Administration Rolls Back Birth Control Mandate". The ...
Transvaginal mesh has recently come under scrutiny due to controversy relating to the Food and Drug Administration. Initially, ... is called intravaginal slingplasty (IVS).[medical citation needed] The procedure of choice for stress urinary incontinence in ... is called intravaginal slingplasty (IVS).[medical citation needed] The transobturator tape (TOT or Monarc) sling procedure aims ...
Pharmacokinetics of progesterone
Advantages of intravaginal progesterone over oral administration include high bioavailability, rapid absorption, avoidance of ... However, the duration was short, with levels of less than 5 ng/mL at 6 hours, and re-administration had to be done two or three ... With oral administration, progesterone accounts for less than 20% of the dose in circulation while 5α- and 5β-reduced products ... 5-year) administration. This is potentially consistent with a weak proliferative effect of oral progesterone on the breasts ...
... are polymeric drug delivery devices designed to provide controlled release of drugs for intravaginal administration over ... not to be confused with hymenal ring Vaginal rings (also known as intravaginal rings, or V-Rings) ...
List of MeSH codes (E05)
... administration, intravaginal MeSH E05.300.120.505 - administration, intravesical MeSH E05.300.120.610 - administration, rectal ... administration, buccal MeSH E05.300.100.878 - administration, sublingual MeSH E05.300.120.040 - administration, buccal MeSH ... E05.300.120.060 - administration, cutaneous MeSH E05.300.120.080 - administration, intranasal MeSH E05.300.120.500 - ...
Estrogen - intravaginal administration helps to prevent pelvic muscle atrophy The surgery to repair the anterior vaginal wall ...
... prostaglandin E2 Intravaginal or oral administration of misoprostol Cervical insertion of a 30-mL Foley catheter Rupturing the ...
... is a route of administration where the substance is applied inside the vagina. Pharmacologically, ... Medicines primarily delivered by intravaginal administration include vaginally administered estrogens and progestogens (a group ... It is a potential means of artificial insemination (referred to as intravaginal insemination or IVI), sometimes used at home ... It is used as an administration method for contraception. Alexander, Nancy J.; Baker, Edward; Kaptein, Marc; Karck, Ulrich; ...
Sarah Davis (politician)
In 2011, Davis voted against a bill to require physicians to conduct intra-vaginal sonograms, prior to even pharmaceutically ... In 2013, she voted against a bill that increases abortion facility requirements, regulates the administration of abortion ...
In the United States, they are considered to be a Class II medical device by the Food and Drug Administration (FDA). They are ... Tierno, Philip M.; Hanna, Bruce A. (1985-02-01). "Amplification of Toxic Shock Syndrome Toxin-1 by Intravaginal Devices". ... The absorbency rates required by the U.S. Food and Drug Administration (FDA) for manufacturer labeling are listed below: ... Section 801.430: User labeling for menstrual tampons: U.S. Food and Drug Administration. Retrieved 11 February 2017.CS1 maint: ...
Route of administration
intravaginal administration, in the vagina. *intravenous (into a vein), e.g. many drugs, total parenteral nutrition ... extra-amniotic administration, between the endometrium and fetal membranes. *nasal administration (through the nose) can be ... Administration through the gastrointestinal tract is sometimes termed enteral or enteric administration (literally meaning ' ... Strictly enteral administration (directly into the intestines) can be used for systemic administration, as well as local ( ...
WHO Model List of Essential Medicines
for buccal administration when solution for oromucosal administration is not available *^ The presence of both 25 mg/5 mL and ... Intravaginal contraceptives. *Progesterone vaginal ring[note 85]. Ovulation inducers. *Clomifeneα ... cloxacillin, dicloxacillin and flucloxacillin are preferred for oral administration due to better bioavailability. ...
a b c Government, A. ( 2010). Australian Public Assessment Report for Dapoxetine (D. o. H. a. A. T. G. Administration, Trans.). ... Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 ... Its maximum plasma concentration (Cmax) is reached 1-2 hours after oral administration. The Cmax and AUC (Area Under the plasma ... As at 2005, Dapoxetine was in phase III clinical trials, pending review by the Federal Drug Administration (FDA). ...
... is a route of administration where the substance is applied inside the vagina. Pharmacologically, ... Medicines primarily delivered by intravaginal administration include vaginally administered estrogens and progestogens (a group ... It is a potential means of artificial insemination (referred to as intravaginal insemination or IVI), sometimes used at home ... Woolfson, A. David; Malcolm, R. Karl; Gallagher, Rory (2000-01-01). "Drug Delivery by the Intravaginal Route". Critical Reviews ...
In particular, intravaginal ejaculation latency time (IELT) was found to increase with 6-13-fold, which was somewhat longer ... On June 28, 2013, the U.S. Food and Drug Administration approved low-dose paroxetine for the treatment of moderate-to-severe ... Paroxetine is well-absorbed following oral administration. It has an absolute bioavailability of about 50%, with evidence ... Plasma, serum, or blood concentrations of paroxetine may be measured to monitor therapeutic administration, confirm a diagnosis ...
Food and Drug Administration (2011). Approved Drug Products with Therapeutic Equivalence Evaluations - FDA Orange Book 31st ... In particular, intravaginal ejaculation latency time (IELT) was found to increase with 6-13-fold, which was somewhat longer ... Food and Drug Administration (2011). Approved Drug Products with Therapeutic Equivalence Evaluations - FDA Orange Book 31st ... On June 28, 2013, the U.S. Food and Drug Administration approved low-dose paroxetine for the treatment of moderate-to-severe ...
Truvada was previously only approved by the U.S. Food and Drug Administration (FDA) to treat HIV in those already infected. In ... For example, a vaginal gel formulation of tenofovir and an intravaginal ring releasing dapivirine are under investigation for ... "U.S. Food and Drug Administration Approves Gilead's Truvada for Reducing the Risk of Acquiring HIV". Gilead. Retrieved 15 ... In Australia, the country's Therapeutic Goods Administration approved the use of Truvada as PrEP in May 2016, allowing ...
Herpes simplex research
... virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal ... efficacy of Vitaherpavac vaccine was demonstrated after allergometry-based tailored choice of vaccine administration regimen. ...
A monthly intravaginal ring containing dapivirine has been developed as a way of preventing infection by human immunodeficiency ... Further regulatory submissions are planned to the US Food and Drug Administration, the South African Health Products Regulatory ... Two phase 3 clinical trials of intravaginal dapivirine rings for HIV prevention were completed in 2015 and results were ...
The administration of estradiol halts, or reverses atrophic changes that occur due to the loss of endogenous estradiol during ... "Dydrogesterone Versus Intravaginal Progesterone in the Luteal Phase Support". ClinicalTrials.gov. Pandian RU (December 2009). " ... Oral administration of progestins dydrogesterone at least similar live birth rate than vaginal progesterone capsules when used ... With oral administration of dydrogesterone, circulating levels of 20α-DHD are substantially higher than those of dydrogesterone ...
Women in Islam
From the writings of the jurists it emerges that other methods of birth control - mostly intravaginal tampons - were also used ... Hasna, F (2003). "Islam, social traditions and family planning". Social Policy & Administration. 37 (2): 181-197. doi:10.1111/ ... through imperial administrations. In contrast with the biblical account of the Fall, in Islamic tradition Eve (Ḥawwā) did not ... responsible for endowing five madrasas and could even have the responsibility of being a supervisor of a madrasa administration ...
... and estrogen of more than 500 pg/mL on the day of hCG administration. However, GnRH agonist administration at the time of ... This procedure is therefore sometimes referred to as 'intravaginal insemination' (IVI). Sperm supplied by a sperm bank will be ... June 2009). "GnRH agonist administration at the time of implantation does not improve pregnancy outcome in intrauterine ... follicle count at hCG administration day, follicle rupture, and the number of uterine contractions observed after the second ...
recommends the periodic administration of booster doses every 2 years to maintain protective immunity for many years. The ... McGrory T, Garber GE (June 1992). "Mouse intravaginal infection with Trichomonas vaginalis and role of Lactobacillus ... Intramuscular administration of inactivated aberrant lactobacilli provokes a humoral immune response. The production of ...
FGA is used as an intravaginal sponge preparation to synchronize estrus in ewes and goats. FGA, also known as 17α-acetoxy-9α- ... Food and Drug Administration: Parts 500-599, Revised April 1, 2012. Government Printing Office. pp. 359-. ISBN 978-0-16-090718- ...
Intravaginal administration - Wikipedia
Intravaginal administration is a route of administration where the substance is applied inside the vagina. Pharmacologically, ... Medicines primarily delivered by intravaginal administration include vaginally administered estrogens and progestogens (a group ... It is a potential means of artificial insemination (referred to as intravaginal insemination or IVI), sometimes used at home ... It is used as an administration method for contraception. Alexander, Nancy J.; Baker, Edward; Kaptein, Marc; Karck, Ulrich; ...
Intravaginal administration - Wikipedia
Intravaginal administration is a route of administration where the substance is applied inside the vagina. Pharmacologically, ... Medicines primarily delivered by intravaginal administration include vaginally administered estrogens and progestogens (a group ... It is a potential means of artificial insemination (referred to as intravaginal insemination or IVI), sometimes used at home ... Woolfson, A. David; Malcolm, R. Karl; Gallagher, Rory (2000-01-01). "Drug Delivery by the Intravaginal Route". Critical Reviews ...
Administration, Intravaginal | Harvard Catalyst Profiles | Harvard Catalyst
Intravaginal" by people in Harvard Catalyst Profiles by year, and whether "Administration, Intravaginal" was a major or minor ... "Administration, Intravaginal" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Administration, Intravaginal" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Administration, Intravaginal". ...
Innovative 3D Printed Intravaginal Ring AnelleO-PRO, the first Single Administration of Progesterone for Infertility | SBIR.gov
Innovative 3D Printed Intravaginal Ring AnelleO-PRO, the first Single Administration of Progesterone for Infertility. Award ... overarching goal of this proposal is to develop and evaluate an innovative approach to creating and manufacturing intravaginal ... of sustained release of progesterone to women who undergo infertility treatment is highly significantLong acting intravaginal ... designsOur goal is to address these limitations by revolutionizing the engineering and manufacturing processes for intravaginal ...
Liposome: Encapsula's Scientific Blog: Intravaginal Administration of Clodrosome (Clodronate encapsulated liposomes)
Although not addressed specifically in this paper, it is a further assumption that the phagocyte depletion after intravaginal ... 1 prior to intravaginal challenge by HSV-2 on day 0. ~80% of the macrophages and dendritic cells were depleted from the vagina ... could be depleted by direct intravaginal instillation of clodronate liposomes. ...
A prospective randomized study on oestradiol valerate supplementation in addition to intravaginal micronized progesterone in...
... prospective randomized study was conducted to evaluate the use of adding oestradiol valerate 6 mg per os daily to intravaginal ... Administration, Intravaginal. Biopsy. Buserelin / therapeutic use*. Clinical Protocols. Estradiol / analogs & derivatives*, ... A prospective randomized study on oestradiol valerate supplementation in addition to intravaginal micronized progesterone in ... whether or not oestradiol valerate was added to intravaginal progesterone. Eighteen out of twenty-two endometrial biopsies were ...
Self-administered Intravaginal 2% Lidocaine Gel Prior to Intrauterine Device Insertion in Nulliparous Women - Study Results -...
Group 2: Intravaginal Placebo Gel. 4mL placebo gel (K-Y Jelly) for vaginal self-administration ... Intravaginal insertion of 4ml of placebo gel (K-Y Jelly) Participant Flow: Overall Study Group 1: Intravaginal 2% Lidocaine Gel ... Group 1: Intravaginal 2% Lidocaine Gel. 4mL of 2% lidocaine gel for vaginal self-administration ... Group 1: Intravaginal 2% Lidocaine Gel Group 2: Intravaginal Placebo Gel Total ...
Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses
Here we investigated CD8+ T cell responses in the female mouse cervicovaginal mucosa after intravaginal … ... Papillomavirus Vaccines / administration & dosage* * Papillomavirus Vaccines / genetics * Respiratory Syncytial Virus ... Intravaginal HPV prime/boost reduced cervicovaginal viral titers 1,000-fold after intravaginal challenge with vaccinia virus ... Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses J Clin Invest. 2012 Dec;122(12):4606- ...
Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection - Full Text View - ClinicalTrials.gov
Administration, intravaginal. Anti-infective agents. Double blind method. Drug evaluation. Female. Gels. HIV infections/ ... Naphthalenesulfonates/administration and dosage. Polymers/administration and dosage. Sexual behavior. Vaginal creams, foams and ... A phase I study of a novel potential intravaginal microbicide, PRO 2000, in healthy sexually inactive women. Sex Transm Infect ...
Vaginal delivery - Wikipedia
Synchronization of ovulation and fertility in weaned sows treated with intravaginal triptorelin is influenced by timing of...
... of ovulation and fertility in weaned sows treated with intravaginal triptorelin is influenced by timing of administration and ... of ovulation and fertility in weaned sows treated with intravaginal triptorelin is influenced by timing of administration and ... of ovulation and fertility in weaned sows treated with intravaginal triptorelin is influenced by timing of administration and ... of ovulation and fertility in weaned sows treated with intravaginal triptorelin is influenced by timing of administration and ...
Patent US5912006 - Compositions and methods for alleviating discomforting menstrual pain - Google Patents
The composition is administered by topical or local administration to the uterus or vaginal tissues of a women in need thereof ... Intravaginal Administration. A composition of this invention, such as the formulations of Example 1, may be delivered via a ... The method of administration is therefore significantly more selective than oral administration and, as a result, smaller ... Administration of Composition for Reducing or Alleviating Menstrual Pain. The following example illustrates the administration ...
Topical testosterone for breast cancer patients with vaginal atrophy related to aromatase inhibitors: a phase I/II study
POLYVINYL ALCOHOL (JECFA 52, 2004)
c) Intravaginal administration Five female Fischer 344 rats received a single dose of 0.5 mg of 14C-labelled polyvinyl alcohol ... Two groups of 50 female B6C3F1 mice received 20 l of a 25% aqueous solution of polyvinyl alcohol by intravaginal administration ... The Committee also noted a report that more polyvinyl alcohol was absorbed after intravaginal than oral administration, and ... polyvinyl alcohol by intravaginal administration, 5 days per week for 104 105 weeks. A second control group of 100 animals were ...
Metronidazole Hydrochloride Monograph for Professionals - Drugs.com
Metronidazole: pseudomembranous colitis following intravaginal administration. J Medicina Clinica. 1987; 88:652. ... Metronidazole Hydrochloride Dosage and Administration. Administration. Administer orally152 197 430 or by continuous or ... Efficacy of intravaginal 0.75% metronidazole gel for the treatment of bacterial vaginosis. Obstet Gynecol. 1993; 81:963-7. http ... Oral Administration. Administer extended-release tablets at least 1 hour before or 2 hours after meals.430 ...
Bacterial vaginosis - Wikipedia
Pre-exposure Prophylaxis Prevents Intravaginal HIV-1 Tr | Open-i
Pre-exposure Prophylaxis Prevents Intravaginal HIV-1 Transmission in Humanized BLT Mice(A) Kaplan-Meier plot of the time course ... Adenine/administration & dosage/analogs & derivatives*/therapeutic use. *Anti-HIV Agents/administration & dosage/therapeutic ... Adenine/administration & dosage/analogs & derivatives*/therapeutic use. *Anti-HIV Agents/administration & dosage/therapeutic ... pmed-0050016-g002: Pre-exposure Prophylaxis Prevents Intravaginal HIV-1 Transmission in Humanized BLT Mice(A) Kaplan-Meier plot ...
Misoprostol administration in first-trimester pregnancies with embryonic demise reduces uterine arterial blood flow.
Administration, Intravaginal. Adolescent. Adult. Arteries / physiology*, ultrasonography. Cohort Studies. Female. Humans. ... Misoprostol / administration & dosage*, adverse effects. Pregnancy. Pregnancy Trimester, First. Pulsatile Flow / drug effects. ... Abortifacient Agents, Nonsteroidal / administration & dosage*, adverse effects. Abortion, Induced. Abortion, Missed. ... RESULTS AND CONCLUSION: All Doppler indices increased significantly after misoprostol administration (p , 0.0001), suggesting ...
Metronidazole Gel - FDA prescribing information, side effects and uses
Topical administration of a one gram dose of metronidazole to the face of 13 patients with moderate to severe rosacea once ... Not for oral, ophthalmic or intravaginal use.. Dosage Forms and Strengths. Gel, 1%. Metronidazole is a colorless to slightly ... After oral administration, metronidazole is secreted in breast milk in concentrations similar to those found in the plasma. ... Metronidazole Gel Dosage and Administration. Apply and rub in a thin film of metronidazole once daily to affected area(s). ...
Eskata (Hydrogen Peroxide Topical Solution): Uses, Dosage, Side Effects, Interactions, Warning
DOSAGE AND ADMINISTRATION. Important Administration Information. ESKATA is to be administered by a health care provider. ... Not for oral, ophthalmic, or intravaginal use.. Do not apply ESKATA topical solution to open or infected seborrheic keratoses. ... Dosage And Administration Instructions. Preparation Of The ESKATA Applicator. Wear nitrile or vinyl examination gloves during ... Report Problems to the Food and Drug Administration. You are encouraged to report negative side effects of prescription drugs ...
Desonate (Desonide Gel): Side Effects, Interactions, Warning, Dosage & Uses
DOSAGE AND ADMINISTRATION. Apply a thin layer to the affected areas two times daily and rub in gently. Discontinue use when ... Not for oral, ophthalmic, or intravaginal use.. HOW SUPPLIED. Dosage Forms And Strengths. Gel, 0.05%; (0.5mg/g) desonide in a ... Report Problems to the Food and Drug Administration. You are encouraged to report negative side effects of prescription drugs ... It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce ...
Route of administration - Wikipedia
Intravaginal administration, in the vagina. Intravenous (into a vein), e.g. many drugs, total parenteral nutrition. ... Oral administration is often denoted "PO" from "per os", the Latin for "by mouth". The bioavailability of oral administration ... Strictly enteral administration (directly into the intestines) can be used for systemic administration, as well as local ( ... Extra-amniotic administration, between the endometrium and fetal membranes. Nasal administration (through the nose) can be used ...
Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in...
Intravaginal administration of lactobacilli has been found to reduce the number of coliform bacteria in the periurethral area ... A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections. N Engl J Med 1993; ... Fecal recovery following oral administration of Lactobacillus strain GG (ATCC 53103) in gelatine capsules to healthy volunteers ...
Patients With Vulvovaginal Candidiasis - Full Text View - ClinicalTrials.gov
WO2015023601A1 - Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery ...
This invention relates to biphasic lipid-vesicle compositions and methods for treating cervical displasia by intravaginal ... by intravaginal administration, particularly in the treatment of cervical dysplasia.  A preferred method of preparing a ... Pharmaceutical compositions for parenteral or local administration US6193997B1 (en) 2001-02-27. Proteinic drug delivery system ... Composition for transdermal and dermal administration of interferon-α WO1997030695A1 (en) 1997-08-28. Drug delivery ...
Patent US6086856 - System for delivering foamed oral hygiene compositions - Google Patents
Cutaneous and Mucosal HIV Vaccination | CUT'HIVAC Project | FP7 | CORDIS | European Commission
optimise standard operating procedures of needle-free method of intravaginal mucosal administration of vaccines,. • advance ... The results from this study showed that biodistribution of the plasmid is restricted to the site of administration and that ... understand skin and mucosal mode of administration for the development of new needle-free vaccination strategies against HIV in ... CUTHIVAC-001 is using a HIV multi-clade DNA-GTU® strategy applied or injected by differential routes of administration ...
Immunoactive prophylaxis of recurrent urinary tract infections: a meta-analysis
Vaginal micronized progesterone and risk of preterm delivery in high-risk twin pregnancies: secondary analysis of a placebo...
DailyMed - CLINDAMYCIN - BENZOYL PEROXIDE- clindamycin phosphate and benzoyl peroxide gel
2 DOSAGE AND ADMINISTRATION 3 DOSAGE FORMS AND STRENGTHS 4 CONTRAINDICATIONS 4.1 Hypersensitivity 4.2 Colitis/Enteritis 5 ... Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/5% is not for oral, ophthalmic, or intravaginal use. ... 2 DOSAGE AND ADMINISTRATION Apply a thin layer of Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/5% to the face once ... DOSAGE AND ADMINISTRATION •. Apply a thin layer of Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/5% to the face once ...
MisoprostolPreparationsProgesteroneFormulationsSubcutaneousOralEjaculatory latency timeMeSHContraceptiveEstrogenDHEAInoculationCervicalMetronidazoleTenofovirUterineVaginallyParenteralCrinoneInfertilityRegimenTherapeuticDosageSHIVMacaquesProphylaxisFertilityIntradermalInfectionFood and Drug AdminRectalTopical administrationAcuteTrimesterMethodsMiceVaginal drugBiopharmaceuticalRoute of administratSystemicEffectivenessPregnancyInjectionHumansIntravenous administrationDeliveryRoutes of administratSecondaryMinorDosesFemale
- Misoprostol administration in first-trimester pregnancies with embryonic demise reduces uterine arterial blood flow. (biomedsearch.com)
- METHODS: Transvaginal ultrasonographic Doppler examinations (resistance index, pulsatility index, systolic/diastolic ratio) of the uterine arteries in 61 pregnant women were performed before misoprostol administration and 90 min later. (biomedsearch.com)
- Expectant management of missed spontaneous abortion has variable success rates, but medical therapy with intravaginal misoprostol has an 80 percent success rate. (aafp.org)
- ABSTRACT To assess the effectiveness of intravaginal misoprostol for second trimester uterine evacuation, we studied 70 women with singleton pregnancies complicated by fetal malformation or dead fetuses. (who.int)
- Administration of misoprostol is an effective clinical method to terminate second trimester, complicated pregnancy. (who.int)
- RÉSUMÉ Afin d'évaluer l'efficacité du misoprostol intravaginal pour une évacuation utérine au deuxième trimestre, nous avons examiné 70 femmes ayant une grossesse unique compliquée par une malformation ou une mort foetale. (who.int)
- Mifepristone-misoprostol medical abortion: home administration of misoprostol in Guadeloupe. (semanticscholar.org)
- 50 mcg oral misoprostol has the potential to induce labor as safely and effectively as the intravaginal route. (bioline.org.br)
- Misoprostol is reasonably priced synthetic prostaglandin E1 analogue (13), and its oral administration has obvious appeal because it offers ease and higher patient satisfactoriness and promises outpatient administration if proved safe and effective for cervical ripening and labor induction but it has been studied less comprehensively. (bioline.org.br)
- This study was a comparative analysis of the effectiveness and safety of oral misoprostol and intravaginal misoprostol for the use in the process of cervical ripening and inducing labor in multigravida postdate pregnancies with a live fetus. (bioline.org.br)
- A new progesterone vaginal gel (Crinone) has sustained-release properties that were not available in the original intravaginal preparations. (aafp.org)
- In fact, even at the lowest dose and dosing regimen, all intravaginal estrogen preparations increase serum estrogens above the normal postmenopausal range or above the threshold of no biological activity with the accompanying risk of systemic effects' . (imsociety.org)
- Avoid concurrent use with other intravaginal preparations (see Interactions). (mims.com)
- Medicines primarily delivered by intravaginal administration include vaginally administered estrogens and progestogens (a group of hormones including progesterone), and antibacterials and antifungals to treat bacterial vaginosis and yeast infections respectively. (wikipedia.org)
- A prospective randomized study on oestradiol valerate supplementation in addition to intravaginal micronized progesterone in buserelin and HMG induced superovulation. (biomedsearch.com)
- A prospective randomized study was conducted to evaluate the use of adding oestradiol valerate 6 mg per os daily to intravaginal micronized progesterone (600 mg daily) as luteal supplements. (biomedsearch.com)
- The clinical pregnancy rate was similar (29%) whether or not oestradiol valerate was added to intravaginal progesterone. (biomedsearch.com)
- This study provided no evidence of any benefit of routinely supplementing GnRHa/HMG cycles with oestradiol valerate in addition to intravaginal micronized progesterone. (biomedsearch.com)
- Natural progesterone is obtained primarily from plant sources and is currently available in injectable, intravaginal and oral formulations. (aafp.org)
- Transvaginal progesterone delivery is the most practical nonoral route of administration. (aafp.org)
- Intravaginal progesterone gel (Crinone 8%) is FDA-approved for use as a part of infertility treatment in women. (webmd.com)
- In hospice care, a specialized rectal catheter, designed to provide comfortable and discreet administration of ongoing medications provides a practical way to deliver and retain liquid formulations in the distal rectum, giving health practitioners a way to leverage the established benefits of rectal administration. (wikipedia.org)
- Intravaginal administration of drugs requires the development of formulations suited to the area and adherence to the treatment can be increased if mucoadhesive formulations are obtained which avoid discomfort and provide adequate release of the active compounds. (clinicaltrials.gov)
- Both parties will leverage each other's drug development and manufacturing strengths: Particle Sciences has a proven track record and extensive expertise in the development and manufacturing of intravaginal ring devices and complex formulations, while Encube Ethicals has strong capabilities in developing complex topical and transdermal delivery systems, with two decades of experience in commercial manufacturing of Topical products for a variety of markets, including women's health for multiple countries. (scientistlive.com)
- We are working with major pharma companies to co-develop and market new intravaginal and dermal foam formulations," says Dr. Dov Tamarkin, CEO of Foamix Ltd. (bio-medicine.org)
- Such ring system can be used for the intravaginal, intraperitoneal, and subcutaneous delivery of at least one bioactive agent, including those used as contraceptives. (google.com)
- Animal studies involving rats revealed embryofetal toxicities (embryofetal deaths, decreased live fetuses, placental effects) following subcutaneous administration of doses 559-times the maximum recommended human dose. (pdr.net)
- 341 alternative regimens are a 7-day regimen of oral clindamycin or 3-day regimen of intravaginal clindamycin suppositories. (drugs.com)
- Not for oral, ophthalmic or intravaginal use. (drugs.com)
- Common examples include oral and intravenous administration. (wikipedia.org)
- Enteral/enteric administration usually includes oral (through the mouth) and rectal (into the rectum) administration, in the sense that these are taken up by the intestines. (wikipedia.org)
- 2. The method of claim 1 wherein (S)-desethyloxybutynin is administered by inhalation or by parenteral, transdermal, rectal or oral administration. (google.com.au)
- The only oral azole agent approved for this indication by the US Food and Drug Administration (FDA) is fluconazole, which also achieves a high cure rate. (medscape.com)
- Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain. (patents.com)
- No. 637,363 describes paper films coated with pharmaceutically active medicinal compounds suitable for oral administration. (google.ca)
- it is not for ophthalmic administration, oral administration, or vaginal administration. (pdr.net)
- NAFTIN Gel is not for ophthalmic, oral, or intravaginal use. (globalrph.com)
- Acute and residual interactive effects of repeated administrations of oral methamphetamine and alcohol in humans. (medscape.com)
- can be used intravaginal y or oral y and has excellent shelf-life. (who.int)
- 2.4 First aid measures and management principles In case of oral overdosage the common measures to limit the absorption of the drug from gastrointestinal tract, such as emesis, gastric lavage or administration of activated charcoal, should be performed, if patient seen early after ingestion. (intox.org)
- Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens - J Clin Endocrinol Metab 1999 Jun;84(6):2170-6 - 'Serum testosterone and dihydrotestosterone remained unchanged after DHEA administration. (qualitycounts.com)
- 88 women were selected for the study where 44 were randomised in the oral group (group A) and the remaining in the intravaginal group B. All of the women were recruited at Bahawal Victoria Hospital, Bahawalpur, Pakistan, a 1300 bedded tertiary referral center with an average annual delivery rate of 2500. (bioline.org.br)
- Hiroi M, Stanczyk FZ, Goebelsmann U, Brenner PF, Lumkin ME, Mishell DR, Jr. Radioimmunoassay of serum medroxyprogesterone acetate (Provera) in women following oral and intravaginal administration. (springer.com)
Ejaculatory latency time2
- Effects of vardenafil administration on intra-vaginal ejaculatory latency time in men with lifelong premature ejaculation. (francoangeli.it)
- A total of 60 patients diagnosed with erectile dysfunction were retrospectively evaluated using the international index of erectile function questionnaire-5 (IIEF-5), intravaginal ejaculatory latency time (IELT) and international prostate symptoms scores (IPSS). (scielo.br)
- Administration, Intravaginal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- A process for making a multicomponent microbicidal contraceptive intravaginal ringed-mesh device that includes forming a polymeric, fibrous mesh and adjoining a reinforcing yarn about the periphery of the fibrous mesh. (google.com)
- EndoCeutics) suggest it may be a viable alternative to intravaginal estrogen in combatting dryness and painful sex after menopause . (medscape.com)
- Nonhormonal creams and lubricants are also alternatives to intravaginal estrogen and can temporarily ease pain with sex, but they cannot correct the physical changes that produce the symptoms as DHEA can, according to the authors. (medscape.com)
- Continuous, unopposed estrogen administration is acceptable in women without a uterus. (pdr.net)
- Cite this: Intravaginal DHEA Eases Postmenopausal Vaginal Dryness, Pain - Medscape - Jan 06, 2016. (medscape.com)
- Among the recently approved medications is prasterone - an intravaginal DHEA preparation [1,2]. (imsociety.org)
- Such data indicating a lower estrogenic and androgenic global exposure in women diagnosed with VVA offers an opportunity for the local intravaginal administration of DHEA to replace the deficiency in endogenous DHEA. (deepdyve.com)
- Efficacy of Intravaginal Dehydroepiandrosterone (DHEA) on Moderate to Severe Dyspareunia and Vaginal Dryness, Symptoms of Vulvovaginal Atrophy, and of the Genitourinary Syndrome of Menopause - Medscape, 3/22/16 - 'The daily intravaginal administration of 0.50% (6.5 mg) DHEA (Prasterone) has shown clinically and highly statistically significant effects on the four coprimary parameters suggested by the US Food and Drug Administration. (qualitycounts.com)
- Pre-exposure Prophylaxis Prevents Intravaginal HIV-1 Transmission in Humanized BLT Mice(A) Kaplan-Meier plot of the time course to plasma antigenemia conversion following intravaginal HIV-1 exposure in BLT mice with or without the 7-d pre-exposure regimen of FTC/TDF (administered once daily starting 48 h prior to intravaginal inoculation). (nih.gov)
- and a worldwide are the first cells infected after intravaginal inoculation (3), retrospective case-control study. (cdc.gov)
- This invention relates to biphasic lipid-vesicle compositions and methods for treating cervical displasia by intravaginal delivery. (google.com)
- The case of acute hemoperitoneum after intravaginal administration of PGE 2 for cervical ripening has been rarely reported. (hindawi.com)
- Foley catheter to administration of prostaglandins (PG) and and affordable cervical ripening and medical induction agent. (who.int)
- A lot of evidences have highlighted the importance of prostaglandins for initiation and normal progress of labor (7) as well as to induce cervical ripening and stimulate uterine contractions at a variety of doses and routes of administration i.e. orally or vaginally (8, 9). (bioline.org.br)
- Safety and efficacy of intravaginal metronidazole in children have not been established. (mims.com)
- Although very rarely, the possible adverse reactions (in gel administration) are: Hypersensitivity: Hypersensitivity reactions with chills, fever, erythema and maculopapular rash may develop after administration of a single dose of metronidazole in patients who have had a history of itching or rash during metronidazole intravaginal therapy. (mims.com)
- Tenofovir disoproxil fumarate intravaginal ring for HIV pre-exposure prophylaxis in sexually active women: a phase 1, single-blind, randomised, controlled trial. (harvard.edu)
- An intravaginal ring containing tenofovir protected all but one macaque monkey given hormonal contraceptives and repeatedly exposed to a hybrid human/simian virus similar to HIV, according to a late-breaker presentation at the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) this month in Denver. (aidsmap.com)
- Another approach uses a hollow urethane intravaginal ring containing tenofovir disoproxil fumarate (TDF) powder and sodium chloride. (aidsmap.com)
- Intravaginal administration produces uterine effects with minimal systemic side effects. (aafp.org)
- We examined the pharmacokinetics and efficacy of GSK744 LA as PrEP against repeat high-dose intravaginal SHIV challenge in female rhesus macaques treated with Depo-Provera (depot medroxyprogesterone acetate), which promotes viral transmission vaginally. (sciencemag.org)
- Parenteral administration can be performed by injection, that is, using a needle (usually a hypodermic needle) and a syringe, or by the insertion of an indwelling catheter. (wikipedia.org)
- Locations of application of parenteral administration include: Central nervous system: Epidural (synonym: peridural) (injection or infusion into the epidural space), e.g. epidural anesthesia. (wikipedia.org)
- In these women, the benefits of Crinone administration need to be weighed against the risks. (mims.com)
- Intravaginal administration of SAF could lead to infertility in Balb/c mice. (hindawi.com)
- The therapeutic regimen for acute fungal infections by C. albicans should consider the intensity of the clinical symptoms, recurrence, patient preference for the route of administration and consequent adherence to treatment, presence of pregnancy and the possibility of side effects. (clinicaltrials.gov)
- The most advantageous dosing regimen, timing, and route of administration lingered the focus of enduring research (10-12). (bioline.org.br)
- Mitogen Activated Protein Kinase Kinase 2 inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. (reportbuyer.com)
- Bronchitis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. (reportsnreports.com)
- Treatment should not exceed 4 consecutive weeks [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)
- Route of administration and dosage form are aspects of drug delivery. (wikipedia.org)
- A suppository is a solid dosage form that fits for rectal administration. (wikipedia.org)
- 14. The pharmaceutical unit dosage form of claim 10 wherein said table or capsule is formulated for controlled release upon administration. (google.com.au)
- Pharmaceutical composition unit dosage forms adapted for enteral or topical administration are described, comprising a safe and effective amount of a pharmaceutically active medicament compound dissolved or uniformly dispersed in a flexible, water-soluble film carrier therefor. (google.ca)
- This invention relates to pharmaceutical compositions in unit dosage form comprising a pharmaceutically active medicament compound and a flexible, water-soluble film carrier therefor adapted for enteral or topical administration. (google.ca)
- The intravaginal ring fully protected macaques from SHIV infection throughout the 16 weeks. (aidsmap.com)
- In that analysis, six macaques were fitted with intravaginal rings containing 120mg TDF. (aidsmap.com)
- The utility of humanized mice to study intravaginal HIV-1 transmission is particularly highlighted by the demonstration that pre-exposure prophylaxis can prevent intravaginal HIV-1 transmission in the BLT mouse model. (nih.gov)
- The administration of postexposure prophylaxis has become the standard of care for occupational exposures to HIV. (cdc.gov)
- We look forward to working with the strong management team at Ferring as we further develop intravaginal culture technology to meet important fertility treatment needs. (prnewswire.com)
- Clinical trials will be implemented with last cutting-edge generation of HIV DNA-GTU® candidate applied by transcutaneous, intradermal routes and/or mucosal administration of HIV-envelop protein-based vaccine. (europa.eu)
- Given the importance of this route of transmission, we investigated the susceptibility of humanized mice to intravaginal HIV-1 infection. (nih.gov)
- We show that the female reproductive tract of humanized bone marrow-liver-thymus (BLT) mice is reconstituted with human CD4+ T and other relevant human cells, rendering these humanized mice susceptible to intravaginal infection by HIV-1. (nih.gov)
- The fact that humanized BLT mice are susceptible to intravaginal infection makes this system an excellent candidate for preclinical evaluation of both microbicides and pre-exposure prophylactic regimens. (nih.gov)
Food and Drug Admin8
- In an earlier interview with Reuters Health, Dr Labrie said he expects approval by the US Food and Drug Administration this year. (medscape.com)
- The Food and Drug Administration has given the go-ahead to a new device to control female urinary incontinence. (kcbd.com)
- The project is Particle Sciences' latest in the complex generics space using the 505(b)(2) US Food and Drug Administration (FDA) regulatory pathway to develop new drugs that better meet the requirements of patients and physicians. (scientistlive.com)
- The Food and Drug Administration nominated low-viscosity polyvinyl alcohol for a 2-year study because of concern about the lack of information about the long-term toxic and carcinogenic effects by the intravaginal route. (nih.gov)
- On July 16, the U.S. Food and Drug Administration (FDA) approved Ruconest, the first recombinant C1-Esterase Inhibitor product for the treatment of acute attacks in adult and adolescent patients with hereditary angioedema. (americannursetoday.com)
- On June 13, the U.S. Food and Drug Administration (FDA) a new use for Lymphoseek (technetium 99m tilmanocept) Injection, a radioactive diagnostic imaging agent used to help determine the extent that squamous cell carcinoma has spread in the body's head and neck region. (americannursetoday.com)
- On March 19, the U.S. Food and Drug Administration (FDA) approved Impavido (miltefosine) to treat a tropical disease called leishmaniasis. (americannursetoday.com)
- On Nov. 6, the U.S. Food and Drug Administration (FDA) approved Xeljanz (tofacitinib) to treat adults with moderately to severely active rheumatoid arthritis who have had an inadequate response to, or who are intolerant of, methotrexate. (americannursetoday.com)
- ESKATA (hydrogen peroxide) topical solution, 40% (w/w) is a clear, colorless solution for topical administration, which contains the active ingredient, hydrogen peroxide. (rxlist.com)
- An exception is topical administration, which generally means that both the application location and the effect thereof is local. (wikipedia.org)
- Topical administration is sometimes defined as both a local application location and local pharmacodynamic effect, and sometimes merely as a local application location regardless of location of the effects. (wikipedia.org)
- Here we present a case in which acute hemoperitoneum was observed after administration of prostaglandin E 2 in a pregnant woman. (hindawi.com)
- Avoid Fladystin administration during pregnancy (especially during the 1st trimester) and lactation, especially when using high doses (see Contraindications). (mims.com)
- In (D), note that in seven of eight tested BLT mice, a single exposure to HIV-1 led to intravaginal transmission and an initial drop, with subsequent stabilization, in the levels of peripheral blood CD4+ human T cells. (nih.gov)
- the timing of administration mice needed to have intact cellular immunity (5). (cdc.gov)
- Female B6C3F 1 mice received polyvinyl alcohol (approximately 99% pure) in deionized water by intravaginal administration for 30 days or 2 years. (nih.gov)
- Three groups of 50 female B6C3F 1 mice were used in this intravaginal study. (nih.gov)
- Three groups of 100 female B6C3F 1 mice were used in this intravaginal study: an untreated control group, a vehicle control group receiving 20 µL deionized water vehicle only, and a dosed group receiving 20 µL 25% polyvinyl alcohol in deionized water. (nih.gov)
- Why consider vaginal drug administration? (wikipedia.org)
- Under the partnership the two companies will develop innovative intravaginal rings with the intent to out-license to biopharmaceutical marketing partners. (scientistlive.com)
- MEDFORD, Mass. , Jan. 14, 2019 /PRNewswire/ -- INVO Bioscience, Inc. (OTCQB: IVOB), developers of the INVOcell intravaginal culture (IVC) system, and Ferring Pharmaceuticals, a specialty biopharmaceutical group committed to helping people around the world build families and live better lives, announced today the closing of the previously announced exclusive U.S. commercialization rights agreement for INVOcell. (prnewswire.com)
Route of administrat4
- Intravaginal administration is a route of administration where the substance is applied inside the vagina. (wikipedia.org)
- A route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. (wikipedia.org)
- However, uptake of drugs administered orally may also occur already in the stomach, and as such gastrointestinal (along the gastrointestinal tract) may be a more fitting term for this route of administration. (wikipedia.org)
- It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. (reportbuyer.com)
- Pharmacologically, it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix) with limited systemic adverse effects compared to other routes of administration. (wikipedia.org)
- Strictly enteral administration (directly into the intestines) can be used for systemic administration, as well as local (sometimes termed topical), such as in a contrast enema, whereby contrast media is infused into the intestines for imaging. (wikipedia.org)
- The partnership will focus on rings for the administration of existing approved drugs, improving drug effectiveness and patient compliance. (scientistlive.com)
- A WHO III multicentered trial comparing the use, effectiveness, side effects and bleeding patterns of Depo-Provera and norethisterone enanthate (NET-EN) was terminated after only 1 year because of excessively high pregnancy rates with NET-EN. (popline.org)
- There is also clear evidence that administration of DES in large doses during pregnancy increases the subsequent risk of breast cancer and that DES increases the risk of testicular cancer in males exposed in utero . (inchem.org)
- Intracerebral (into the cerebrum) administration by direct injection into the brain. (wikipedia.org)
- The invention is directed to a family of bioactive intravaginal ring devices formed of at least two polymeric materials, at least one bioactive agent capable of exhibiting antibacterial, antifugal, and/or antiviral activity in the vagina and surrounding tissues of animals and humans without comprising the function of useful microflora therein. (google.com)
- The following adverse reactions have been described: Cardiac arrhythmias (intravenous administration). (intox.org)
Routes of administrat3
- Routes of administration are generally classified by the location at which the substance is applied. (wikipedia.org)
- Routes of administration are usually classified by application location (or exposition). (wikipedia.org)
- Exceptions include the transdermal or transmucosal routes, which are still commonly referred to as routes of administration. (wikipedia.org)
- Kashani J, Ruha AM. Methamphetamine toxicity secondary to intravaginal body stuffing. (medscape.com)
- This graph shows the total number of publications written about "Administration, Intravaginal" by people in Harvard Catalyst Profiles by year, and whether "Administration, Intravaginal" was a major or minor topic of these publication. (harvard.edu)
- In animals, a weak antiandrogenic effect is seen with prolonged administration of very high doses of 10 to 100 mg/kg. (bionity.com)
- Here we investigated CD8+ T cell responses in the female mouse cervicovaginal mucosa after intravaginal immunization with human papillomavirus vectors (HPV pseudoviruses) that transiently expressed a model antigen, respiratory syncytial virus (RSV) M/M2, in cervicovaginal keratinocytes. (nih.gov)