Nonoxynol: Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Nonoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide, formulated primarily as a component of vaginal foams and creams.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Spermatocidal Agents: Chemical substances that are destructive to spermatozoa used as topically administered vaginal contraceptives.Administration, Intravaginal: The insertion of drugs into the vagina to treat local infections, neoplasms, or to induce labor. The dosage forms may include medicated pessaries, irrigation fluids, and suppositories.Vaginal Creams, Foams, and Jellies: Medicated dosage forms for topical application in the vagina. A cream is a semisolid emulsion containing suspended or dissolved medication; a foam is a dispersion of a gas in a medicated liquid resulting in a light, frothy mass; a jelly is a colloidal semisolid mass of a water soluble medicated material, usually translucent.Anti-HIV Agents: Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.Condoms: A sheath that is worn over the penis during sexual behavior in order to prevent pregnancy or spread of sexually transmitted disease.Anti-Infective Agents, Local: Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.HIV-1: The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.Contraceptive Devices, Female: Contraceptive devices used by females.Dysmenorrhea: Painful menstruation.Docosahexaenoic Acids: C22-unsaturated fatty acids found predominantly in FISH OILS.Eicosapentaenoic Acid: Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Salicylic Acid: A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Menstruation: The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)Vagina: The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)Administration, Intravaginal: The insertion of drugs into the vagina to treat local infections, neoplasms, or to induce labor. The dosage forms may include medicated pessaries, irrigation fluids, and suppositories.Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.Clotrimazole: An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.Ketoconazole: Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.Imidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Product Labeling: Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.Drug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Candida: A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.Product Packaging: Form in which product is processed or wrapped and labeled. PRODUCT LABELING is also available.Oral Hygiene: The practice of personal hygiene of the mouth. It includes the maintenance of oral cleanliness, tissue tone, and general preservation of oral health.Oral Hygiene Index: A combination of the debris index and the dental calculus index to determine the status of oral hygiene.Dentifrices: Any preparations used for cleansing teeth; they usually contain an abrasive, detergent, binder and flavoring agent and may exist in the form of liquid, paste or powder; may also contain medicaments and caries preventives.Mouthwashes: Solutions for rinsing the mouth, possessing cleansing, germicidal, or palliative properties. (From Boucher's Clinical Dental Terminology, 4th ed)Pipidae: A family of the order Anura, distinguished by the lack of a tongue. It includes four living genera of aquatic "toads". Two of the most familiar pipids are the popularly called Surinam "toad" (Pipa pipa) and XENOPUS LAEVIS.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Hygiene: The science dealing with the establishment and maintenance of health in the individual and the group. It includes the conditions and practices conducive to health. (Webster, 3d ed)Surface-Active Agents: Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.Toothbrushing: The act of cleaning teeth with a brush to remove plaque and prevent tooth decay. (From Webster, 3d ed)Pulmonary Surfactants: Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.Animal Testing Alternatives: Procedures, such as TISSUE CULTURE TECHNIQUES; mathematical models; etc., when used or advocated for use in place of the use of animals in research or diagnostic laboratories.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.Animal Welfare: The protection of animals in laboratories or other specific environments by promoting their health through better nutrition, housing, and care.Animal Experimentation: The use of animals as investigational subjects.Animals, LaboratoryAnimal Use Alternatives: Alternatives to the use of animals in research, testing, and education. The alternatives may include reduction in the number of animals used, replacement of animals with a non-animal model or with animals of a species lower phylogenetically, or refinement of methods to minimize pain and distress of animals used.Animal Care Committees: Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).Toxicity Tests: An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.Universal Precautions: Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.Drug Users: People who take drugs for a non-therapeutic or non-medical effect. The drugs may be legal or illegal, but their use often results in adverse medical, legal, or social consequences for the users.
(1/486) Women's interest in vaginal microbicides.

CONTEXT: Each year, an estimated 15 million new cases of sexually transmitted diseases (STDs), including HIV, occur in the United States. Women are not only at a disadvantage because of their biological and social susceptibility, but also because of the methods that are available for prevention. METHODS: A nationally representative sample of 1,000 women aged 18-44 in the continental United States who had had sex with a man in the last 12 months were interviewed by telephone. Analyses identified levels and predictors of women's worry about STDs and interest in vaginal microbicides, as well as their preferences regarding method characteristics. Numbers of potential U.S. microbicide users were estimated. RESULTS: An estimated 21.3 million U.S. women have some potential current interest in using a microbicidal product. Depending upon product specifications and cost, as many as 6.0 million women who are worried about getting an STD would be very interested in current use of a microbicide. These women are most likely to be unmarried and not cohabiting, of low income and less education, and black or Hispanic. They also are more likely to have visited a doctor for STD symptoms or to have reduced their sexual activity because of STDs, to have a partner who had had other partners in the past year, to have no steady partner or to have ever used condoms for STD prevention. CONCLUSIONS: A significant minority of women in the United States are worried about STDs and think they would use vaginal microbicides. The development, testing and marketing of such products should be expedited.  (+info)

(2/486) Mucosal vaccination strategies for women.

Women were immunized orally, rectally, or vaginally with a recombinant cholera toxin B-containing vaccine to determine which of these mucosal immunization routes generate the greatest levels of antibody in the female genital tract and rectum. ELISA was used to measure concentrations of cholera toxin B-specific IgA and IgG antibody in serum and secretions before and after three immunizations. Each immunization route similarly increased specific IgG in serum and specific IgA in saliva. Only the vaginal route increased IgA antibodies in genital tract secretions and could be shown to induce a local IgG response. However, vaginal immunization failed to produce antibody in the rectum. In a similar fashion, rectal immunization elicited highest concentrations of locally derived IgA and IgG antibody in the rectum but was ineffective for generating antibody in the genital tract. The data suggest that local immunization may induce the greatest immune responses in the female genital tract and rectum of humans.  (+info)

(3/486) Pharmacokinetics of natural progesterone administered in the form of a vaginal tablet.

Our study was conducted to assess the pharmacokinetics of natural progesterone administered in the novel formula of an effervescent vaginal tablet. Fifty post-menopausal women, with a median age of 43.5 years (range 28-55), volunteered to participate in the research. All women discontinued their hormonal replacement therapy 1 month prior to the study. The pharmacokinetics of 50 and 100 mg of progesterone administered as a vaginal tablet were evaluated. After the initial administration of 50 mg or 100 mg, a mean serum Cmax of 20.43 +/- 8.01 nmol/l and 31.61 +/- 12.62 nmol/l (P < 0.0004) was reached at a Tmax of 6.1 +/- 2.63 and 6.4 +/- 3.35 h respectively. The terminal half-life was 13.18 +/- 1.3 and 13.7 +/- 1.05 h respectively. Continuous use of the 100-mg tablet resulted in a mean serum progesterone concentration of 26.08 +/- 13.96 nmol/l and 21.42 +/- 16.32 nmol/l after 14 and 30 days respectively. Women >40 years were found to have a significantly lower Tmax compared to younger women (P = 0.02). The continuous use of vaginal progesterone did not influence the hormonal, liver or lipid profiles evaluated. Only three (6%) women suffered from mild vaginal irritation. Natural progesterone given as a vaginal tablet is well tolerated, safe and an easily administered treatment. Even in a non-oestrogenized vagina the absorption was efficient and the 100 mg dosage resulted in adequate serum progesterone concentrations.  (+info)

(4/486) Estradiol with or without progesterone and ambulatory blood pressure in postmenopausal women.

The purpose of this study was to determine whether transdermal estradiol and intravaginal progesterone given in doses to mimic the premenopausal state would lower blood pressure (BP) in postmenopausal women. Fifteen healthy postmenopausal women were studied in each of 3 conditions: on placebo, after 8 weeks of transdermal estradiol 0.2 mg twice per week, and again 2 weeks after addition of intravaginal progesterone 300 mg/d. Women were studied at each point after 2 days of 100 mmol/d sodium intake. Twenty-four-hour ambulatory BP monitoring was performed, and blood was assayed for estradiol, progesterone, and hormones of the renin-angiotensin-aldosterone system (RAAS). ANOVA with pairwise comparisons was used for analysis. Urinary sodium excretion was similar at each time point. Levels of estrogen and progesterone similar to those in premenopausal women were achieved. On estradiol, nocturnal systolic BP (110+/-3 mm Hg), diastolic BP (63+/-2 mm Hg), and mean BP (77+/-2 mm Hg) fell significantly (P<0.02) compared with placebo systolic BP (116+/-2 mm Hg), diastolic BP (68+/-2 mm Hg), and mean BP (82+/-2 mm Hg). Daytime BP followed the same trend but was significantly lower only for mean BP. There was no activation of the RAAS. The addition of progesterone resulted in no further fall in BP but a significant activation of the RAAS. Thus, contrary to what is often assumed, administration of estradiol with or without progesterone not only did not raise BP but rather substantially lowered BP. This BP-lowering effect may be responsible for the lower incidence of hypertension in premenopausal than in postmenopausal women.  (+info)

(5/486) Does an acidic medium enhance the efficacy of vaginal misoprostol for pre-abortion cervical priming?

Absorption pharmacokinetics reveal a relationship between plasma concentrations of misoprostol and its therapeutic effect. To achieve a constant plasma profile and optimal efficacy, it is important to develop a medium that ensures complete dissolution of vaginal misoprostol tablets. Vaginal misoprostol is said to liquefy better in an acidic medium; thus, the aim of this study was to determine whether a 200 microg misoprostol tablet dissolved in acetic acid would be more efficacious than 200 microg misoprostol dissolved in water for pre-abortion cervical priming. A total of 120 healthy nulliparous women requesting legal termination of pregnancy between 6-12 weeks gestation were allocated randomly to either of the study groups. Vacuum aspiration was performed 3-4 h after insertion of the misoprostol tablet. Using Hegar's dilator, the degree of cervical dilatation before operation was measured. Of 60 women, 14 (23%) achieved a cervical dilatation of >/=8 mm when the misoprostol dose was dissolved in acetic acid; 12 (20%) achieved a similar cervical dilatation when the dose was dissolved in water. The mean cervical dilatation for the acid and water media used was 6.3 mm and 6.2 mm respectively; these differences were not statistically significant, neither were pre-operative and intra-operative blood losses statistically different between the two groups. Twenty-four (40%) and four (7%) respectively of women in whom a water medium was used experienced vaginal bleeding and abdominal pain; 20 (33%) and 0 women respectively among those in whom an acetic acid medium was used experienced vaginal bleeding and abdominal pain. These differences in side effects were not statistically significant. Our study shows that the use of acetic acid to dissolve vaginal misoprostol does not improve the efficacy in achieving successful cervical dilatation for pre-abortion cervical priming.  (+info)

(6/486) Persistent dominant follicle alters pattern of oviductal secretory proteins from cows at estrus.

The experimental objective was to compare synthesis of oviductal secretory proteins of dairy cows bearing a persistent dominant follicle (PDF) versus a fresh dominant follicle (FDF) at estrus. On Day 7 after synchronized estrus (Day 0), cows received an intravaginal progesterone device and injection of prostaglandin F2alpha (PGF2alpha). On Day 9, cows received an injection of a GnRH agonist (FDF group; n = 3) or received no injection (PDF group, n = 3). On Day 16, all cows received PGF2alpha, and progesterone devices were removed. At slaughter on Day 18 or Day 19, oviducts ipsilateral and contralateral to the dominant follicle were divided into infundibulum, ampulla, and isthmus regions. Explants from oviductal regions were cultured in minimal essential medium supplemented with [3H]leucine for 24 h. Two-dimensional fluorographs of proteins in conditioned media were analyzed by densitometry. Rate of incorporation of [3H]leucine into macromolecules was greater in the infundibulum, ampulla, and isthmus of FDF cows (p < 0.01). Overall, intensities of radiolabeled secretory protein (P) 2 and P13 were greater for FDF than for PDF. In the ampulla, P14 was more intense for FDF while P7 was more intense for PDF. Abundance of P1 in the isthmus was greater for PDF cows. Across regions, P5, P6, P8, P9, and P11 were more intense for PDF than for FDF in the ipsilateral side. In the contralateral side, P19 was more intense for PDF than for FDF, whereas P6, P8, P9, and P11 were more intense for FDF. Differences in biosynthetic activity and in secreted oviductal proteins from cows bearing a PDF may contribute to the decrease in fertility associated with a PDF.  (+info)

(7/486) Ovulation and estrus characteristics in crossbred Brahman heifers treated with an intravaginal progesterone-releasing insert in combination with prostaglandin F2alpha and estradiol benzoate.

Crossbred Brahman heifers (n = 60) were studied to determine the effect of a 7-d intravaginal progesterone-releasing insert (INSERT) in combination with PG (Lutalyse; 25 mg i.m.) and estradiol benzoate (EB; .5 mg i.m.) on time of ovulation and estrous behavior. In Phase I, heifers at unknown stages of the estrous cycle were assigned by BW and body condition score to one of the three treatments on d 0: 1) INSERT for 7 d and PG on d 7 (CONTROL; n = 10); 2) INSERT for 7 d, PG on d 7, and EB 24 h after INSERT removal (EB24; n = 10); or 3) INSERT for 7 d, PG on d 7, and EB 48 h after INSERT removal (EB48; n = 10). Blood samples were collected every 8 h after INSERT removal. Also, blood sampling and ultrasonography began 8 h after the onset of estrus, determined with HeatWatch devices, and every 4 h thereafter to detect ovulation. In Phase II, Phase-I treatments (n = 10/treatments) were replicated, but only behavioral estrus data were collected to minimize handling of heifers. Frequent handling of heifers did not influence (P > .1) the interval from INSERT removal to the onset of HeatWatch and visual estrus and duration of estrus, so behavioral estrus data were combined for Phases I and II. Interval from INSERT removal to HeatWatch estrus was decreased (P < .05) in EB24 (45.5 h) vs EB48 (55.9 h) and CONTROL (59.2 h). Interval from INSERT removal to ovulation differed (P < .04) between CONTROL, EB24, and EB48 (93.5, 74.5, and 78.9 h, respectively). Ovulatory follicle size was similar (P > .1) between CONTROL, EB24, and EB48 (14.4, 12.5, and 14.1 mm, respectively). Duration of estrus was similar for CONTROL, EB24, and EB48 (14.0, 15.1, and 17.6 h, respectively). No difference (P > . 1) was observed in number of mounts received between CONTROL, EB24, and EB48 (28.0, 25.7, and 39.4, respectively), but number of mounts received increased in Phase II vs Phase I (40.0 and 22.2, respectively; P < .05). In conclusion, EB hastened the interval from INSERT removal to ovulation without altering duration of estrus or number of mounts received. Frequent handling of heifers did not affect interval to first mount received after INSERT removal or duration of estrus, but it decreased the total number of mounts received.  (+info)

(8/486) Luteal support with micronized progesterone following in-vitro fertilization using a down-regulation protocol with gonadotrophin-releasing hormone agonist: a comparative study between vaginal and oral administration.

This study aimed to compare the efficacy of micronized progesterone administered as luteal support following ovulation induction for in-vitro fertilization (IVF)- embryo transfer in cycles using gonadotrophin-releasing hormone agonist, either orally (200 mgx4/day) or vaginally (100 mgx2/day) and to characterize the luteal phase hormonal profile during such treatments. A total of 64 high responder patients requiring intracytoplasmic sperm injection due to male factor infertility were prospectively randomized into two treatment groups. Patients treated orally or vaginally were comparable in age (31.9 +/- 6.1 versus 30.6 +/- 5.2; mean +/- SD), number of oocytes retrieved (17 +/- 8.2 versus 18 +/- 7.0), and number of embryos transferred (3.1 +/- 1.2 versus 2.7 +/- 0.9) per cycle. Following low dose vaginal treatment, a significantly higher implantation rate (30.7 versus 10.7%, P < 0.01), but similar clinical pregnancy rate (47.0 versus 33.3%) and ongoing pregnancy rate (41.1 versus 20.0%) was observed, compared with oral treatment. In conception cycles, luteal serum progesterone and oestrogen concentrations did not differ between the treatment groups. In non-conception cycles, late luteal progesterone concentrations were significantly lower following vaginal treatment. As low dose micronized progesterone administered vaginally is simple, easy and well tolerated, it could be recommended as the method of choice for luteal support, especially for high responder patients at risk for ovarian hyperstimulation syndrome.  (+info)

*  Intravaginal administration
... is a route of administration where the substance is applied inside the vagina. Pharmacologically, ... Drugs primarily delivered by intravaginal administration include vaginally administered estrogens and progestogens (a group of ... It is a potential means of artificial insemination (referred to as intravaginal insemination or IVI), sometimes used at home ... Woolfson, A. David; Malcolm, R. Karl; Gallagher, Rory (2000-01-01). "Drug Delivery by the Intravaginal Route". Critical Reviews ...
*  Bacterial vaginosis
Intravaginal administration is preferred to taking them by mouth. Prolonged repetitive courses of treatment appear to be more ... VandeVusse, L; Hanson, L; Safdar, N (2013). "Perinatal outcomes of prenatal probiotic and prebiotic administration: an ...
*  Vaginal estrogen
... is a form of estrogen that is delivered by intravaginal administration. Vaginally administered estrogens are ...
*  Vardenafil
"Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation". ... On 18 October 2007, the U.S. Food and Drug Administration (FDA) announced that a warning about possible deafness (sudden ... Food and Drug Administration. 2007-10-18. Retrieved 2009-08-06. Kloner, Robert A. (2005-12-26). "Pharmacology and drug ...
*  Estrogen (medication)
Rigg LA, Milanes B, Villanueva B, Yen SS (1977). "Efficacy of intravaginal and intranasal administration of micronized ... This route of administration is thus preferred in women with a history of thrombo-embolic disease. Estrogen is also used in the ... However, such risks have been found to vary depending on the type of estrogen or progestogen and the route of administration. ... It was only until 1941 when estrogen therapy was finally approved by the Food and Drug Administration (FDA) for the treatment ...
*  Vaginal ring
... are polymeric drug delivery devices designed to provide controlled release of drugs for intravaginal administration over ... Vaginal rings (also known as intravaginal rings, or V-Rings) ...
*  Luteal support
Formulations for intramuscular administrations Vaginal tablets or other inserts for intravaginal administration, such as ... A Cochrane review in 2011 found no evidence favoring a specific route of administration, dosage or duration of progesterone for ... Luteal support is the administration of medication, generally progesterone, progestins or GnRH agonists, to increase the ... but the evidence suggested the route of progesterone administration did not matter. ...
*  Cystocele
Estrogen - intravaginal administration helps to prevent pelvic muscle atrophy The surgery to repair the anterior vaginal wall ...
*  Route of administration
... is most commonly used for spinal anesthesia and chemotherapy Intrauterine intravaginal administration, in the vagina ... Strictly enteral administration (directly into the intestines) can be used for systemic administration, as well as local ( ... extra-amniotic administration, between the endometrium and fetal membranes nasal administration (through the nose) can be used ... Parenteral administration generally acts more rapidly than topical or enteral administration, with onset of action often ...
*  Obstetrics
... prostaglandin E2 Intravaginal or oral administration of misoprostol Cervical insertion of a 30-mL Foley catheter Rupturing the ...
*  Labor induction
Intravaginal, endocervical or extra-amniotic administration of prostaglandin, such as dinoprostone or misoprostol. ... Intravenous administration of synthetic oxytocin preparations. A high dose does not seem to have greater benefits than a ...
*  Progesterone (medication)
Advantages of intravaginal progesterone over oral administration include high bioavailability, rapid absorption, avoidance of ... In contrast to oral administration, parenteral progesterone, such as with vaginal administration, avoids the first-pass effect ... Administration of as much as 1,000 mg progesterone via intramuscular injection in humans was uneventful in terms of toxicity, ... Progesterone for vaginal administration is available in the form of a gel or insert (suppository). With vaginal and rectal ...
*  Fenticonazole
Intravaginal preparations of fenticonazole may damage latex contraceptives and additional contraceptive measures are therefore ... necessary during local administration. The Merck Index, 12th Edition. 4047. ...
*  Controlled internal drug release
They also allow administration of a natural form of hormone, as opposed to the potent analogues used in sponges. A dose of 550 ... Previously, intravaginal progestogen sponges were a common method of estrus manipulation in ewes. The development and success ... Unlike intravaginal progestogen sponges, CIDRs do not absorb or impede drainage of natural vaginal secretions, offering a ... CIDRs are similar to the progesterone-releasing intravaginal device (PRID), also used for synchronization of estrous cycles in ...
*  Embryo transfer
A recent meta-analysis showed that the intravaginal route with an appropriate dose and dosing frequency is equivalent to daily ... A duration of progesterone administration of 11 days results in almost the same birth rates as longer durations. Patients are ... While daily intramuscular injections of progesterone-in-oil (PIO) have been the standard route of administration, PIO ... beneficial to administer an additional drug that suppresses hormone production by the ovaries such as continuous administration ...
*  Sarah Davis (Texas politician)
In 2011, Davis voted against a bill to require physicians to conduct intra-vaginal sonograms, prior to even pharmaceutically ... In 2013, she voted against a bill that increases abortion facility requirements, regulates the administration of abortion ...
*  Dapoxetine
... 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 ... Johnson in 2003 and submitted as a New Drug Application to the Food and Drug Administration (FDA) for the treatment of PE in ...
*  Flugestone acetate
Food and Drug Administration: Parts 500-599, Revised April 1, 2012. Government Printing Office. pp. 359-. ISBN 978-0-16-090718- ... is a steroidal progestin of the 17α-hydroxyprogesterone group which is used in veterinary medicine as an intravaginal sponge ...
*  Lactobacillus brevis
Kishi A, Uno K, Matsubara Y, Okuda C, Kishida T (August 1996). "Effect of the oral administration of Lactobacillus brevis subsp ... Raz, R., & Stamm, W. E. (1993). A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract ...
*  Ospemifene
Kusiak V (2013-02-13). "NDA Approval" (PDF). U.S. Food and Drug Administration. Unkila M, Kari S, Yatkin E, Lammintausta R ( ... and ospemifene administered as an intravaginal suppository. Estradiol was used as a positive control and raloxifene was used ... U.S. Food and Drug Administration. 2013-02-26. "Ospemifene: Indications, Side Effects, Warnings". Drugs.com. EP application ... U.S. Food and Drug Administration. Bachmann GA, Komi JO (2010). "Ospemifene effectively treats vulvovaginal atrophy in ...
*  Cervical cap
The cap remains in the vagina for a minimum of 6 - 8 hours after the last intravaginal ejaculation. It is recommended the cap ... Food and Drug Administration FDA (1988). "Notice, 11 July 1988". Annual Review of Population Law. 15: 19. PMID 12289360. ... This law required all manufacturers of medical devices to provide the United States Food and Drug Administration (FDA) with ... dead link] "Birth Control Guide". U.S. Food and Drug Administration. December 2003. Retrieved 2008-04-26. Stopes pp.138, 160 ...
*  Estriol
Vooijs GP, Geurts TB (1995). "Review of the endometrial safety during intravaginal treatment with estriol". Eur. J. Obstet. ... including for oral and vaginal administration. Estriol is an estrogen, specifically an agonist of the estrogen receptors ERα ... influence of different routes of administration". Climacteric. 8 Suppl 1: 3-63. doi:10.1080/13697130500148875. PMID 16112947. ...
*  Hormone replacement therapy (menopause)
... an effect which is not seen with topical administration. Transdermal and transvaginal administration are not subject to first ... For example, vaginally administered estrogens include those given by intravaginal tablets, creams and rings, and can have more ... The FDA has stated that BHT is unsupported by medical evidence, and its administration is considered false and misleading by ... The current indications for use from the U.S. Food and Drug Administration include short-term treatment of menopausal symptoms ...
*  HIV/AIDS in Mozambique
2001). "Population Movements and the Spread of HIV/AIDS in Mozambique". Journal of Health and Human Services Administration. 24 ... such as intravaginal practices; intergenerational and transactional sex; "widow cleansing," where a close relative of the ... such as the administration of ART medication to HIV-positive breastfeeding mothers, the Mozambican government has been ... antiretroviral therapy administration, and treatment of co-infections, that more directly identify ways by which the HIV ...
*  Zeda Rosenberg
In that capacity, she directed HIV prevention clinical trials, providing leadership, planning, implementation, administration ... delivered from an intravaginal ring. AIDS Res Hum Retro. 25: 483-488, 2009. Nel A, Smythe S, Young K, Malcolm K, McCoy C, ... Rosenberg Z, Romano J. Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIV- ...
A new intravaginal ring enables the long-lasting vaginal delivery of tenofovir (TFV) shows to be effective in HIV prevention, say scientists.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies. ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
The Penn Medicine Womens Health Clinical Research Center is a division of the Department of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania. This Center is a non-profit organization designed to assist investigators in conducting high quality patient oriented research in womens health. ...
In the absence of an efficient vaccine, prevention of HIV transmission remains the primary and economically feasible infection prevention method available to da...
In todays research we investigate the impact of a variety of TLR ligands and chitosan as potential adjuvants for different routes of mucosal immunisation (sublingual (SL), intranasal (IN), intravaginal (IVag) and a parenteral route (subcutaneous (SC)) in the murine model. to antigen by itself SL>IN?=?SC. A genuine variety of adjuvants elevated particular systemic IgA replies where generally IN>SL>SC immunisation, while for mucosal replies IN?=?SL>SC. On the other hand, immediate intravaginal immunisation didnt induce any detectable systemic or mucosal replies to gp140 also in the current presence of adjuvant. Nevertheless, significant systemic IgG replies to TT had been induced by intravaginal immunisation with or without adjuvant, and detectable mucosal responses IgA and IgG had been observed when TT was administered with FSL-1 or Poly IC. Oddly enough some TLRs shown differential activity influenced by the path of administration. MPLA (TLR4) suppressed systemic replies to SL immunisation ...
Introduction Definition of the Prevention Area Microbicides are products formulated for individuals to apply topically (vaginally or rectally) to reduce their risk of HIV and possibly other sexually transmitted infections. At present, this approach is experimental, although several broad-spectrum microbicides have been clinically evaluated. Microbicides comprise a subset of approaches to pre-exposure prophylaxis (PrEP); oral approaches to PrEP are addressed in a separate entry. Epidemiological Justification for the Prevention Area In generalized epidemics, women are at a disproportionate risk of HIV infection for biological as well as social reasons. Although condoms are highly effective in preventing HIV transmission, it can be difficult for women to negotiate safer sex because the male partner often controls whether a condom is used. Microbicides were initially proposed as a woman-controlled or -initiated prevention method for vaginal application, something a woman could use to protect herself. The
Vaginal rings (also known as intravaginal rings , or V-Rings ) are polymeric drug delivery devices designed to provide controlled release of drugs for intravaginal administration over extended...
Hydroxyethylcellulose containing medications, Hydroxyethylcellulose indications and usages ATC and ICD codes, combinations with other active ingredients and trade names information from Drugs-about.com
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For prevention of HIV, genital herpes and HPV. VivaGel® is being developed as a vaginal microbicide to offer safer sex by preventing transmission of genital herpes (HSV-2), HIV and other sexually transmitted infections (STIs) including human papillomavirus (HPV), the causative agent of cervical cancer.. There is an enormous global need for a vaginal microbicide offering protection of this kind. For example:. ...
The authors report the results of evaluation of the effectiveness of extracorporeal fertilization after the transfer of vitrified blastocysts in the natural cycle and with the use of hormone replacement therapy. It was found that the most effective is the protocol, in which the transfer of vitrified blastocysts occurs in a modified natural menstrual cycle with the support of the luteal phase by intravaginal administration of 90 mg of progesterone in the form of a gel for 2 weeks ...
Flow cytometric analysis of TLR expression in rabbit CVE cells after intravaginal administration of placebo, nisin (15.15 mM in 2 mL of 1% polycarbophil gel) SD
More than 28 years since the first cases of HIV/AIDS, there is still no cure or vaccine. The worst affected region is sub-Saharan Africa and, increasingly, it is young women who are bearing the brunt of the epidemic. Consequently, there is an urgent need for HIV prevention options for women in developing countries. Microbicides are topical products that can be used vaginally by women to impede sexual transmission of HIV and thus represent one of the most promising prevention strategies. Efficacy trials with early nonspecific microbicide gels have so far been unsuccessful, but the field has now switched its focus to products containing highly potent and highly specific antiretroviral drugs that are easier to use, and can be formulated in a variety of dosage forms to suit individual and regional preferences. However, these products have their own challenges, with a greater likelihood of absorption, and the potential for systemic toxicities or the development of resistance in infected individuals ...
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Baloglu E., Şenyiğit Ay Z., Karavana S. Y., Vetter A., Metin D. Y., Hilmioğlu Polat S., Güneri T., Bernkop-Schnurch A., In Vitro Evaluation of Mucoadhesive Vaginal Tablets of Antifungal Drugs Prepared with Thiolated Polymer and Development of a New Dissolution Technique for Vaginal Formulations, Chem. Pharm. Bull. 59, 952-958 (2011 ...
Systemic CD4+ T Cell Loss Resulting from Intravaginal HIV-1 Infection in Humanized BLT Mice(A) Comparison of the levels of CD4+ or CD8+ human T cells in the ind
We thank Dimitrios Papoutsis and Angeliki Antonakou and John OBrien for their comments on our OPPTIMUM trial.1 We are somewhat surprised that Papoutsis and Antonakou describe the editorial accompanying OPPTIMUM as expressing "scepticism"-that was not our interpretation.2 However, we agree that further subgroup analyses might be helpful.. ...
Hi I was just put on progesterone inserts as I had a miscarriage a few months ago and have found out I am expecting again... could you please help me in letting me know if this made anyone sick or had awful side effects?
The field of rectal and vaginal microbicides is a new therapeutic area with several candidates in clinical trials and no registered products. Many of these candidates, with the exception of a 1% tenofovir gel evaluated in the recent CAPRISA 004 trial (1), have failed to demonstrate safety or efficacy. Despite these setbacks, the field is still progressing rapidly due to the pressing need for prophylactic technologies and the advantages of vaginal route of delivery for antiretroviral drugs (9, 16). Typically, drugs delivered through the vaginal route encounter an acidic environment with pH ranging from 4.0 to 5.0 (37, 40). However, soon after intercourse, the vaginal pH increases to a neutral pH due to the introduction of semen. The vaginal environment also hosts several Lactobacillus strains that constantly generate lactic acid and hydrogen peroxide, maintaining an acidic pH in the vaginal cavity (37, 40). Therefore, successful development of a vaginal microbicide product requires an active ...
Human Trial of Vaginal Microbicide Gel PRO 2000 Finds Some Level of HIV Protection, at TheBody.com, the complete HIV/AIDS resource.
Use of the intravaginal progesterone insert (CIDR) along with PGF2a effectively synchronizes estrus in dairy heifers. It is expected to be available in 2001; however, approval for use in lactating cows is not being sought at this time. Approval for use is lactating cows is expected to be sought after approval is acquired for its use in heifers. During 2001 there will be procedures to synchronize estrus in dairy heifers: PGF2a, MGA and PGF2a (discussed in another article within this publication), and the concurrent use of CIDRs and PGF2a. Producers should obtain the advantages of AI and reduce the reliance on estrus detection as heifers are an easy to bred female.. ...
HIV/AIDS is a global pandemic that has claimed the lives of 39 million people and currently afflicts 36.9 million more. These effects are disproportionately felt in sub-Saharan Africa which has almost 70% of those current cases and where women account for 59% of current infections. These numbers are even more disproportionate for young women and complications associated with HIV/AIDS are the leading cause of death in women aged 15-44. This creates a need for female-controlled tools to prevent infection. Microbicides are one such tool. Microbicides are vaginally-delivered topical products that combine a therapeutic agent with activity against HIV and a delivery vehicle. The delivery vehicle can consist of many different formulations, depending on the therapeutic agent used and the delivery mechanism desired. Polymer solutions (known as "gels" in the microbicide field) have received the most attention and have been incorporated into the most formulations for use in clinical trial evaluations. ...
Definition of vaginal creams, foams, and jellies in the Definitions.net dictionary. Meaning of vaginal creams, foams, and jellies. What does vaginal creams, foams, and jellies mean? Information and translations of vaginal creams, foams, and jellies in the most comprehensive dictionary definitions resource on the web.
Approximately 40% of HIV-1 infections occur in the female genital tract (FGT), primarily through heterosexual transmission. FGT factors determining outcome of HIV-1 exposure are incompletely understood, limiting prevention strategies. Here, humanized NOD-Rag1(-/-) γc(-/-) mice differentially reconstituted with human CD34+ -enriched hematopoietic stem cells (Hu-mice), were used to assess target cell frequency and viral inoculation dose as determinants of HIV-1 infection following intravaginal (IVAG) challenge. Results revealed a significant correlation between HIV-1 susceptibility and hCD45+ target cells in the blood, which correlated with presence of target cells in the FGT, in the absence of local inflammation. HIV-1 plasma load was associated with viral dose at inoculation and frequency of target cells. Events following IVAG HIV-1 infection; viral dissemination and CD4 depletion, were not affected by these parameters. Following IVAG inoculation, HIV-1 titres peaked, then declined in vaginal ...
Abstract Intravaginal drug delivery can elicit a local effect, or deliver drugs systemically without hepatic first pass metabolism. There are a number of emerging areas in intravaginal drug delivery, but the vagina is a challenging route of administration, due to the clearance mechanisms present which result in poor retention of dosage forms, and the potential for irritation and other adverse reactions. Gel formulations are desirable due to the ease of application, spreading and that they cause little to no discomfort to the patient. However, these dosage forms, in particular, are poorly retained and traditional gels typically have little control over drug release rates. This has led to a large number of studies on improving the retention of vaginal gels and modulating the controlled release of drugs from the gel matrix. This review outlines the anatomy and physiology of the vagina, focussing on areas relevant to drug delivery. Medical applications of vaginally administered medicines is then ...
AIM: The aim of this paper was to show that self-assessed anxiety in patients with pelvic visceral discomforts is reduced after the intravaginal administration of adelmidrol. MATERIAL AND METHODS: Twenty-four patients who described themselves as anxious (scoring 5 or more in a 1 to 10 scale in a self-assessment test) and who suffered from pelvic visceral discomfort (during defecation, urination, sexual intercourse and menstruation) were enrolled in the study. Pelvic visceral discomforts were assessed using a questionnaire in which patients were asked to assign a score between 1 and 10 according to intensity ...
An experimental vaginal microbicide applied daily protected female monkeys against simian HIV (SHIV) infection, even hours after application, according to ...
Dapivirine, also known as TMC120, is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM. The HIV-1 replication inhibitor dapivirine (DPV) is one of the most promising drug candidates being used in topical microbicide products for prevention of HIV-1 sexual transmission. [last updated: 10/9/2015)
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0119] Not being bound by any particular theory, the process of the present invention can be optimized based on the plastic and elastic properties of the mixture. The plastic and elastic properties of the mixture are substantially inversely related to one another. Thus, as the plasticity of a mixture increases, its elasticity decreases. During compression, the plasticity of the substantially homogeneous mixture permits the mixture to retain the shape that is formed by compressing the mixture. Generally, the plasticity of a mixture increases as the temperature of the mixture is increased, and in particular, the plasticity can increase rapidly above the Tg of a mixture. Thus, one of ordinary skill in the art of compression would expect that a more efficient compression process would occur at a temperature above the Tg of a plastic mixture. However, the process of the present invention compresses a mixture at a temperature below the Tg of the mixture. While controlling the temperature in this manner ...
We have recently reported that the intravaginal instillation of synthetic Toll-like receptor 3 (TLR3) or TLR9 agonists after a subcutaneous vaccination against human papillomavirus E7 highly increases (~5-fold) the number of vaccine-specific CD8+ T cells in the genital mucosa of Dabigatran mice without affecting E7-specific systemic responses. via bacterial components including lipopolysaccharide (LPS a TLR4 agonist) 5 flagellin (a TLR5 agonist)6 and/or bacterial DNA (TLR9 agonist) not only when delivered orally (their normal route of infection) but also when administered in vagina.7 In addition attenuated can be easily engineered to deliver heterologous antigens8 9 and is used as a vaccine (strain Ty21a 10 Vivotif?) against typhoid fever by the oral route since decades with an excellent safety record.11 Here we have investigated whether attenuated serovar Typhimurium vaccine strains would act as an IVAG immunostimulant after E7 vaccination in mice. Result and Discussion Intravaginal ...
1 Answer (question resolved) - Posted in: estrace, estrace vaginal cream - Answer: No. Estrace is the only approved form of estradiol vaginal cream ...
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This invention is directed to a method and device for treating a female patients uterine disorder by occluding one or both of the patients uterine artery. The treatment embodying features of the invention basically involves occluding one or both of the patients uterine arteries with an intravaginal device to form a thrombus within the occluded artery or arteries and administering an agent which will prolong the occlusion of the artery or arteries after removal of the occluding device or initiate or accelerate fibroid cell apoptosis (programmed cell death). The intravaginal device has a pair of pivotally connected occluding members, with at least one of the occluding member having a movable occluding element on a distal shaft section of the occluding member.
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PROBLEM: To characterize the amniotic fluid (AF) inflammatory-related protein (IRP) network in patients with a sonographic short cervix (SCx) and to determine its relation to early preterm delivery (ePTD). METHOD OF STUDY: A retrospective cohort study included women with a SCx (≤25 mm; n=223) who had amniocentesis and were classified according to gestational age (GA) at diagnosis and delivery (ePTD ,32 weeks of gestation). RESULTS: (i) In women with a SCx ≤ 22 1/7 weeks, the concentration of most IRPs increased as the cervix shortened; those with ePTD had a higher rate of increase in MIP-1α, MCP-1, and IL-6 concentrations than those delivering later; and (ii) the concentration of most IRPs and the correlation between several IRP pairs were higher in the ePTD group than for those delivering later ...
The Global Campaign for Microbicides advocates worldwide for user-controlled HIV and STD prevention tools; microbicides, female condoms and cervical barriers. We work to promote their development, assure access and protect users needs and interests.
The recent successful trial of tenofovir vaginal gel provides important proof of concept indicating that a vaginal microbicide can prevent HIV. However, the lim...
<p>Scientists who developed tenofovir, the vaginal gel that could transform AIDS protection for women, are struggling to fund the final trials.</p>
Women who fail to respond to such measures and who request further, non-surgical treatment can be considered for a variety of intravaginal or intraurethral devices. The Conveen Continence Guard(TM) (Coloplast Ltd) is an example of an intravaginal device (see Figure 1). The shape of the device is such that, when it is placed in the vagina, it supports the bladder neck and thus prevents or reduces leaking during physical activity. It is inserted into the vagina with the use of an applicator (see Figure 2) and can be used for up to 16 hours per day.. [[NIP02_fig1_84]]. [[NIP02_fig2_84]]. There is no pharmacological agent currently available that has been shown to be effective in the treatment of patients with genuine stress incontinence. However, randomised placebo-controlled trails are in progress that aim to assess the efficacy of an alpha-adrenergic agonist as well as a 5-HT reuptake inhibitor for the treatment of such patients ...
An experimental vaginal gel has yielded promising results in preventing HIV infection in women, according to clinical trials conducted in Africa and the United States, the US National
Pregnancy & herpes - First Intravaginal Ring to Protect Against Pregnancy, HIV, and Herpes. A liquid oral spray, Herpeset is absorbed quickly into the blood vessels under the tongue to quickly releif your herpes symptoms safley, naturally and discreetly.
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An aqueous foamable composition is provided having a delayed foaming action on expulsion from a pressurized container. The composition comprises a major amount of water, a water-immiscible liquefied gas foaming agent, at least one foam-stabilizing and emulsifying surfactant, and a water-soluble polymer. The composition is particularly useful for rectal or vaginal administration of pharmaceuticals.
Physician reviewed Hemorrhoidal Cooling Gel (rectal) patient information - includes Hemorrhoidal Cooling Gel description, dosage and directions.
Use of progesterone inserts (controlled interval drug release, CIDR) offers another option for synchronizing estrus and ovulation in replacement heifers and lactating dairy cows. Results indicate that heifers may be ...
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Treatment with vaginal progesterone reduced the risk of preterm birth, neonatal complications and death in pregnant women with twins and who have a short cervix - a risk factor for preterm...
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Merck was developing MK 8342B (SCH 900432; ENG CVR), an intravaginal ring product that releases etonogestrel (100 µg/day or 125 µg/day) and estradiol 300 µg/day
Significant findings published in the American Journal of Obstetrics and Gynecology. Women with a short cervix should be treated with vaginal progesterone to prevent preterm birth, according to a landmark study by leading obstetricians around the world. Vaginal progesterone decreased the rate of preterm birth by 42%, and significantly reduced the rate of respiratory distress syndrome and the need for mechanical ventilation, as well as a composite of several complications of premature newborns (e.g. infection, necrotizing enterocolitis, intracranial hemorrhage, etc.). An early online version of the study was published today in the American Journal of Obstetrics and Gynecology (AJOG), and is available on the AJOG website free of charge.. "Our analysis provides compelling evidence that vaginal progesterone prevents preterm birth and reduces neonatal morbidity/mortality in women with a short cervix," said lead investigator Dr. Roberto Romero, Chief of the Perinatology Research Branch and Head of the ...
Hygienic interventions to reduce STI risk among men date back to programmes for servicemen during the first and second world wars.8,9,10 We have initiated three studies involving the use of topical microbicides by men. The first study, reported here, examined genital hygiene attitudes and practices and their temporal relation to sex. The second evaluated the safety and acceptability of three candidate topical microbicide formulations. Thirdly, we are conducting a randomised controlled trial of topical microbicide use by men to prevent the recurrence of BV in their sex partner. This first study demonstrates that men in resource limited areas of Africa realise the importance of bathing and some understand the role of genital hygiene in the transmission of STI. However, perceptions and factors associated with sexual partnerships, and exogenous individual and community level factors may constrain their genital hygiene behaviours.. Bathing at least once daily was linked to educational attainment and ...
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Efficacy and safety of intravaginal misoprostol versus intracervical dinoprostone for labor. or a 10-mg controlled-release vaginal insert known as Cervidil.I was induced with my first using Cervidil and it was great no complications.DECEMBER 2011 Oxytocin for Induction 3 Dear ACOG District II Member: This past January, the American Congress of Obstetricians and Gynecologists (ACOG), District II.. Acquistare Generic Cytotec (Misoprostol) - Farmacia online Acquista Generic Cytotec (Misoprostol) BONUS: - SCONTO -10% per tutti gli ordini successivi.Includes: indications, dosage, adverse reactions, pharmacology and more.Physician reviewed Cervidil patient information - includes Cervidil description, dosage and directions.Dinoprostone Compared With Misoprostol for Cervical Ripening for Induction of Labor at Term. (Cervidil) and should be.. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews ...
Melbourne - Starpharma Holdings Limited announced today that their VivaGel, a vaginal microbicide gel under development for the prevention of sexually transmitted infections, including genital herpes and HIV infection, has been approved in Japan as a patent registration.. This approval means that VivaGel and the VivaGel coated condom are now covered by granted patents in all major markets including Europe, the US and Japan.. Last month Starpharma announced a full licence agreement with SSL International in relation to the VivaGel coated condom. In addition Starpharma is continuing to develop VivaGel as a stand-alone product for use by women to protect themselves from HIV and genital herpes. The development for these two indications has significant NIH support.. The commonly used coating on premium condoms is Nonoxynol 9 (N-9), which has spermicidal properties. However, because of its detergent nature, N-9 has been shown to increase the risk of infection with HIV and other viruses such as HSV-2. ...
RESEARCH ON TOPICAL MICROBICIDES FOR PREVENTION OF STDS/HIV Release Date: April 13, 1998 RFA AVAILABLE: AI-98-011 P.T. National Institute of Allergy and Infectious Diseases Letter of Intent Receipt Date: June 1, 1998 Application Receipt Date: October 15, 1998 APPLICATIONS IN RESPONSE TO THIS REQUEST FOR APPLICATIONS (RFA) MUST BE PREPARED USING SPECIFIC INSTRUCTIONS IN AN NIAID BROCHURE ENTITLED "INSTRUCTIONS FOR APPLICATIONS FOR MULTI-PROJECT AWARDS" (September 1997). PURPOSE The Sexually Transmitted Diseases Branch of the Division of Microbiology and Infectious Diseases (DMID), National Institute of Allergy and Infectious Diseases (NIAID), invites grant applications for program projects to conduct research necessary for the development of topical microbicides for intravaginal and intrarectal use to prevent sexually transmitted diseases (STDs), including Human Immunodeficiency Virus (HIV) infection. The NIAID wishes to continue and expand research in this area through the conduct of ...
Additionally, in a first-of-its-kind joint announcement, two of the world s leading pharmaceutical companies, Merck & Co. and Bristol-Myers Squibb (BMS) today announced that they have signed separate license agreements with the International Partnership for Microbicides to develop two of the compounds evaluated in the study as potential vaginal microbicides to protect women from HIV. Under the agreements, Merck and BMS each will grant the non-profit group a royalty-free license to develop, manufacture and distribute their compounds for use as microbicides in resource-poor countries. Announced on the eve of the TIME Global Health Summit, this agreement marks the first time any pharmaceutical company has licensed an anti-HIV compound for development as a microbicide when the class of drugs is so early in development ...
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MTN-014- A Phase I study to examine drug absorption patterns in both rectal and vaginal tissue when a reduced glycerin formulation of tenofovir gel is applied either vaginally or rectally.The study enrolled 14 women at a U.S. based clinical research site. Results, reported in July 2015, demonstrated that when tenofovir gel was applied into the vagina, a low amount of active drug was distributed to the rectum and, similarly, when the gel was applied into the rectum, a low amount of active drug was distributed to the vagina. More info… ...
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The Global Campaign for Microbicides advocates worldwide for user-controlled HIV and STD prevention tools; microbicides, female condoms and cervical barriers. We work to promote their development, assure access and protect users needs and interests.
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NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Integrated Preclinical/Clinical Program for HIV Topical Microbicides (IPCP-HTM) Competitive Revisions (U19) RFA-AI-10-007. NIAID
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Researchers have developed a new intravaginal ring for the sustained 90-day co-delivery of tenofovir and levonorgestrel, an anti-human immunodeficiency virus (HIV) drug and a contraceptive. Tenofovir is the only topical prophylactic shown to be effective at reducing the sexual transmission of HIV when formulated in a gel . . .. ...
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Vaginal cream: Insert one full applicator of vaginal cream into the vagina at bedtime for 7 consecutive nights. In addition, apply a thin layer of vaginal cream directly to the vulva and massage it in gently.. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are using the medication without consulting your doctor.. It is very important that this medication be used exactly as prescribed. Finish all of the prescribed medication even if you start feeling better. If a dose is missed, apply it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not apply a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.. Store this medication at room ...
UNITED NATIONS - Without a vaccine or a cure for HIV/AIDS, it could prove difficult to end the epidemic by 2030, according to Simon Bland, the director of the Joint United Nations Programme on HIV/AIDS New York office. But UNAIDS is still working ... ...
Drug-resistant bacteria, also known as superbugs, pose a very real threat to public health and well-being. Scientists have developed an antibacterial gel capable of breaking through the its protective casing, killing off certain types of drug-resistant bacteria.
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I am currently taking 200 mg of Prometrium inserted vaginally. My doctor wants me to switch to progesterone suppositories and take the Prometrium
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Im finally just fed up with people poking around up in my uterus. Im generally a healthy person otherwise, but ever since this problematic organ entered service four years ago it has helped me learn more than I ever wanted to know about emergency rooms, blood work, IVs, local and general anesthesia. It has been scraped, probed, irradiated, photographed, ogled at, tested, dissected, resected, injected, and all kinds of other mean, nasty, ugly things. Sometimes it seems like I spend more quality time with speculums and intravaginal ultrasound wands than I do with my husband. Ive just had enough of people messing with it. Im sick of this little temperamental blob of scarred flesh holding my life hostage. I almost hoped one of my tubes was blocked so I could have the satisfaction of telling them not to fix it ...
Číslo patentu: E 13665. Dátum: 15.04.2010. Autori: Gelmi Maria Luisa, Fontana Gabriele, Gassa Federico. MPK: C07C 227/32. Značky: derivátov, izoserínových, spôsob, přípravy. Text:. ...diastereoizoméry po jednoduchom kryštalizačnom kroku.0019 Podla tohto spôsobu imín 4 sa najskôr generuje in situ z aldehydu (RCHO) a amínu(RzNHg, kde PhCHZNHZ je výhodný) v acetonitrile pri teplote miestnosti a v prítomnosti molekulámych sít alebo pomocou destilácie azeotropickej zmesi acetonitril/voda. Reakčná teplota je znížená na -30 °C a pridáva sa silylový derivát 3. Potom sa pridáva katalyzátor a zmes sa mieša v priebehu 1 hodiny. Surová.... ...
Dear Wray, I on 7th day Post IUI and doctor has given me progesterone vaginally as 200 mg x2 per day for initial 15 days. My problem is that when at night
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Its a special treatment available in many forms: capsules, gel and even cream. Our primary goal is presenting all of you with the basic ideas and suggestions of proper use of the Metronidazole gel, cream of capsules for optimal results. Metronidazole is meant to resolve acute symptoms which need immediate relief, rosacea and a lot of other diseases which are treated with it. Everyone interested, should just discover ways to apply Metronidazole gel and obtain amazing results in the shortest possible time. Metronidazole gel may be used even for vaginal infections, using complex treatment prescribed by the doctor. You can easily execute a few clicks facing the computer and discover the basic information regarding this Metronidazole gel, start to see the essential tips you need to follow for attaining actual results. We could also present a listing of special rules of application of Metronidazole gel and simply watch for results to appear. Leave all your vaginal infections in the past, get ...
Fong, Y.F.,Singh, K. (2001). Vaginal misoprostol prior to operative hysteroscopy facilitated the procedure and reduced complications. Evidence-based Obstetrics and Gynecology 3 (2) : 88-90. [email protected] Repository. https://doi.org/10.1054/ebog.2001.0226 ...
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Genital herpes is one of the most prevalent sexually transmitted infections worldwide and is the most common cause of genital ulcers. Despite increased public awareness and the initiation of efforts to prevent transmission, the prevalence of herpes simplex virus (HSV) type 2 continues to increase. What makes HSV so difficult to control is that most sexual and perinatal transmission occurs during unrecognized or asymptomatic shedding. The impact of genital herpes as a public health threat is amplified because of its epidemiological synergy with HIV/AIDS. Thus, there is an urgent need for novel prophylactic methods, such as topical microbicides designed for genital application, to prevent both HSV and HIV transmission. Several candidate microbicides are being advanced to clinical trials based on in vitro activity and animal studies. These include compounds that inactivate virus directly, those that enhance innate immunity, and drugs that block viral binding and entry. A more vigorous evaluation of ...
Use misoprostol as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with misoprostol. Talk to your pharmacist if you have questions about this information. Take misoprostol by mouth with food unless your doctor tells you otherwise. The last dose of the day should be taken at bedtime. Taking misoprostol after meals and at bedtime may decrease the risk of diarrhea. Do not take an antacid that has magnesium in it within 1 hour before or 2 hours after you take misoprostol. If you miss a dose of misoprostol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use misoprostol ...
Use misoprostol as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with misoprostol. Talk to your pharmacist if you have questions about this information. Take misoprostol by mouth with food unless your doctor tells you otherwise. The last dose of the day should be taken at bedtime. Taking misoprostol after meals and at bedtime may decrease the risk of diarrhea. Do not take an antacid that has magnesium in it within 1 hour before or 2 hours after you take misoprostol. If you miss a dose of misoprostol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use misoprostol ...
Use misoprostol as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with misoprostol. Talk to your pharmacist if you have questions about this information. Take misoprostol by mouth with food unless your doctor tells you otherwise. The last dose of the day should be taken at bedtime. Taking misoprostol after meals and at bedtime may decrease the risk of diarrhea. Do not take an antacid that has magnesium in it within 1 hour before or 2 hours after you take misoprostol. If you miss a dose of misoprostol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use misoprostol ...
Use misoprostol as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with misoprostol. Talk to your pharmacist if you have questions about this information. Take misoprostol by mouth with food unless your doctor tells you otherwise. The last dose of the day should be taken at bedtime. Taking misoprostol after meals and at bedtime may decrease the risk of diarrhea. Do not take an antacid that has magnesium in it within 1 hour before or 2 hours after you take misoprostol. If you miss a dose of misoprostol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Ask your health care provider any questions you may have about how to use misoprostol ...
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Anderson DJ, Williams DL, Ballagh SA, Barnhart K, Creinin MD, Newman DR, Bowman FP, Politch JA, Duerr AC, Jamieson DJ. Safety analysis of the diaphragm in combination with lubricant or acidifying microbicide gels: Effects on markers of inflammation and innate immunity in cervicovaginal fluid. Am J Reprod Immunol 2009; 61: 121-129.. U.S. National Library of Medicine abstract ...
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Aim: To evaluate the efficacy and safety of oral misoprostol for labor induction in women with term premature rupture of membranes (PROM) and an unfavorable cervix.. Methods: We randomized 130 women with PROM of ≤4 h to either oral misoprostol, 50 μg, or a placebo given every 4 h for up to three doses. Intravenous oxytocin was initiated if active labor did not begin within 12 h.. Results: Sixty-four women received oral misoprostol and 66 received placebo. The PROM-to-delivery interval was shorter with misoprostol than with placebo (13.7±5.8 vs. 20.3±6.8 h, respectively, P,0.05). Misoprostol significantly reduced the need for oxytocin (28.1 vs. 72.7%, P,0.001) and antibiotics (25 vs. 69.7%, P,0.001). No significant differences in cesarean section or hyperstimulation rate were noted.. Conclusion: Oral misoprostol given to women with unfavorable cervix soon after term PROM significantly reduces the induction-to-delivery time and the need for oxytocin and antibiotics. ...
Product Name: Mifepristone and Misoprostol Tablets. Common Name: contraceptive pills. Strength: available in -. Mifepristone IP 200mg & Misoprostol IP 200mcg. Description: Medical Abortion is a form of early abortion caused by the combination of two medications, mifepristone and misoprostol that is an option for women who are 8 weeks pregnant or less. Also known as RU486 or medication abortion.. During the first appointment at the clinic you receive the mifepristone pill to take orally. Then 24 to 72 hours later, in the privacy, take the the second medication, misoprostol. Misoprostol causes contractions resulting in a miscarriage. When used in combination, mifepristone and misoprostol are 95-97% effective within two weeks. Mifepristone and misoprostol are FDA approved.. Indications and Usage: Mifepristone is used in combination with misoprostol (Cytotec) to end an early pregnancy. Early pregnancy means it has been 70 days or less since your last menstrual period began. Mifepristone is in a ...
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OBJECTIVE To compare the efficacy of 400 microg of misoprostol with that of 1 mg of gemeprost as cervical priming agents when administered vaginally 3 to 4 hours before first-trimester vacuum aspiration abortion. METHODS In a prospective controlled trial 90 nulliparous women who requested termination of pregnancy before 12 weeks gestation were randomized to receive vaginally either misoprostol or gemeprost for cervical priming. The force to dilate the cervix was measured by the use of a cervical tonometer connected to Hegar dilators from 3 to 10 mm. The main outcome measures were baseline cervical dilation; the peak force to dilate the cervix at 8, 9, and 10 mm; and the cumulative force to dilate the cervix to 10 mm. RESULTS Baseline cervical dilation did not differ significantly between the women who received misoprostol and those who were treated with gemeprost. Neither the peak force required to dilate the cervix at 8, 9, and 10 mm nor the cumulative force to dilate the cervix to 10 mm showed
Patent US5912006 - Compositions and methods for alleviating discomforting menstrual pain - Google Patents  Patent US5912006 - Compositions and methods for alleviating discomforting menstrual pain - Google Patents
The composition is administered by topical or local administration to the uterus or vaginal tissues of a women in need thereof ... Intravaginal Administration. A composition of this invention, such as the formulations of Example 1, may be delivered via a ... The method of administration is therefore significantly more selective than oral administration and, as a result, smaller ... Administration of Composition for Reducing or Alleviating Menstrual Pain. The following example illustrates the administration ...
more infohttp://www.google.com/patents/US5912006?dq=6101531
Intravaginal administration - Wikipedia  Intravaginal administration - Wikipedia
Intravaginal administration is a route of administration where the substance is applied inside the vagina. Pharmacologically, ... Drugs primarily delivered by intravaginal administration include vaginally administered estrogens and progestogens (a group of ... It is a potential means of artificial insemination (referred to as intravaginal insemination or IVI), sometimes used at home ... Woolfson, A. David; Malcolm, R. Karl; Gallagher, Rory (2000-01-01). "Drug Delivery by the Intravaginal Route". Critical Reviews ...
more infohttps://en.wikipedia.org/wiki/Intravaginal_administration
Liposome: Encapsulas Scientific Blog: Intravaginal Administration of Clodrosome (Clodronate encapsulated liposomes)  Liposome: Encapsula's Scientific Blog: Intravaginal Administration of Clodrosome (Clodronate encapsulated liposomes)
Although not addressed specifically in this paper, it is a further assumption that the phagocyte depletion after intravaginal ... 1 prior to intravaginal challenge by HSV-2 on day 0. ~80% of the macrophages and dendritic cells were depleted from the vagina ... could be depleted by direct intravaginal instillation of clodronate liposomes. ...
more infohttp://www.liposomes.org/2012/03/intravaginal-administration-of.html
Patients With Vulvovaginal Candidiasis - Full Text View - ClinicalTrials.gov  Patients With Vulvovaginal Candidiasis - Full Text View - ClinicalTrials.gov
Intravaginal administration of drugs requires the development of formulations suited to the area and adherence to the treatment ... patient preference for the route of administration and consequent adherence to treatment, presence of pregnancy and the ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT03024502?term=Clotrimazole&
Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection - Full Text View - ClinicalTrials.gov  Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection - Full Text View - ClinicalTrials.gov
Administration, intravaginal. Anti-infective agents. Double blind method. Drug evaluation. Female. Gels. HIV infections/ ... Naphthalenesulfonates/administration and dosage. Polymers/administration and dosage. Sexual behavior. Vaginal creams, foams and ... A phase I study of a novel potential intravaginal microbicide, PRO 2000, in healthy sexually inactive women. Sex Transm Infect ...
more infohttps://clinicaltrials.gov/show/NCT00262106?order=609
Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection - Full Text View - ClinicalTrials.gov  Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection - Full Text View - ClinicalTrials.gov
Administration, intravaginal. Anti-infective agents. Double blind method. Drug evaluation. Female. Gels. HIV infections/ ... Naphthalenesulfonates/administration and dosage. Polymers/administration and dosage. Sexual behavior. Vaginal creams, foams and ... A phase I study of a novel potential intravaginal microbicide, PRO 2000, in healthy sexually inactive women. Sex Transm Infect ...
more infohttps://clinicaltrials.gov/show/NCT00262106?order=36
POLYVINYL ALCOHOL (JECFA 52, 2004)  POLYVINYL ALCOHOL (JECFA 52, 2004)
c) Intravaginal administration Five female Fischer 344 rats received a single dose of 0.5 mg of 14C-labelled polyvinyl alcohol ... Two groups of 50 female B6C3F1 mice received 20 l of a 25% aqueous solution of polyvinyl alcohol by intravaginal administration ... The Committee also noted a report that more polyvinyl alcohol was absorbed after intravaginal than oral administration, and ... polyvinyl alcohol by intravaginal administration, 5 days per week for 104 105 weeks. A second control group of 100 animals were ...
more infohttp://inchem.org/documents/jecfa/jecmono/v52je09.htm
Misoprostol administration in first-trimester pregnancies with embryonic demise reduces uterine arterial blood flow.  Misoprostol administration in first-trimester pregnancies with embryonic demise reduces uterine arterial blood flow.
Administration, Intravaginal. Adolescent. Adult. Arteries / physiology*, ultrasonography. Cohort Studies. Female. Humans. ... Misoprostol / administration & dosage*, adverse effects. Pregnancy. Pregnancy Trimester, First. Pulsatile Flow / drug effects. ... Abortifacient Agents, Nonsteroidal / administration & dosage*, adverse effects. Abortion, Induced. Abortion, Missed. ... RESULTS AND CONCLUSION: All Doppler indices increased significantly after misoprostol administration (p , 0.0001), suggesting ...
more infohttp://www.biomedsearch.com/nih/Misoprostol-administration-in-first-trimester/14738166.html
Trial protocol OPPTIMUM-- does progesterone prophylaxis for the prevention of preterm labour improve outcome?  Trial protocol OPPTIMUM-- does progesterone prophylaxis for the prevention of preterm labour improve outcome?
17-alpha-Hydroxyprogesterone / administration & dosage, therapeutic use. Administration, Intravaginal. Child. Child Development ... Progesterone / administration & dosage, therapeutic use*. Progestins / administration & dosage, therapeutic use*. Research ... da Fonseca EB,Bittar RE,Carvalho MH,Zugaib M,Prophylactic administration of progesterone by vaginal suppository to reduce the ... Dodd JM,Flenady V,Cincotta R,Crowther CA,Prenatal administration of progesterone for preventing preterm birthCochrane Database ...
more infohttp://www.biomedsearch.com/nih/Trial-protocol-OPPTIMUM-Does-progesterone/22866909.html
Immunoactive prophylaxis of recurrent urinary tract infections: a meta-analysis  Immunoactive prophylaxis of recurrent urinary tract infections: a meta-analysis
Administration, Intravaginal; Antigens, Bacterial /therapeutic use; Bacterial Vaccines /administration & Chemoprevention / ...
more infohttp://www.crd.york.ac.uk/CRDWeb/ShowRecord.asp?AccessionNumber=12009102618
Metronidazole Hydrochloride Monograph for Professionals - Drugs.com  Metronidazole Hydrochloride Monograph for Professionals - Drugs.com
Metronidazole: pseudomembranous colitis following intravaginal administration. J Medicina Clinica. 1987; 88:652. ... Metronidazole Hydrochloride Dosage and Administration. Administration. Administer orally152 197 430 or by continuous or ... Efficacy of intravaginal 0.75% metronidazole gel for the treatment of bacterial vaginosis. Obstet Gynecol. 1993; 81:963-7. http ... Oral Administration. Administer extended-release tablets at least 1 hour before or 2 hours after meals.430 ...
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Vaginal delivery - Wikipedia  Vaginal delivery - Wikipedia
For vaginal delivery in pharmacology, see Intravaginal administration.. Sequence of images showing the stages of a normal ...
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Pre-exposure Prophylaxis Prevents Intravaginal HIV-1 Tr | Open-i  Pre-exposure Prophylaxis Prevents Intravaginal HIV-1 Tr | Open-i
Pre-exposure Prophylaxis Prevents Intravaginal HIV-1 Transmission in Humanized BLT Mice(A) Kaplan-Meier plot of the time course ... Adenine/administration & dosage/analogs & derivatives*/therapeutic use. *Anti-HIV Agents/administration & dosage/therapeutic ... Adenine/administration & dosage/analogs & derivatives*/therapeutic use. *Anti-HIV Agents/administration & dosage/therapeutic ... pmed-0050016-g002: Pre-exposure Prophylaxis Prevents Intravaginal HIV-1 Transmission in Humanized BLT Mice(A) Kaplan-Meier plot ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2194746_pmed.0050016.g002&req=4
GB0417401D0 - Stabilised prostaglandin composition 
      - Google Patents  GB0417401D0 - Stabilised prostaglandin composition - Google Patents
Intravaginal administration of misoprostol CN102302443B (en) * 2011-09-21. 2014-04-23. 天津市聚星康华医药科技有限公司. Misoprostol vaginal ... INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS ... Intravaginal drug delivery device TW446561B (en) * 1997-06-30. 2001-07-21. Dev Center Biotechnology. Improved stabilization of ... Intravaginal clindamycin ovule composition US6642274B1 (en) * 1999-09-09. 2003-11-04. Gary W. Neal. Methods and
more infohttps://patents.google.com/patent/GB0417401D0/en
Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in...  Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in...
Intravaginal administration of lactobacilli has been found to reduce the number of coliform bacteria in the periurethral area ... A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections. N Engl J Med 1993; ... Fecal recovery following oral administration of Lactobacillus strain GG (ATCC 53103) in gelatine capsules to healthy volunteers ...
more infohttps://www.bmj.com/content/322/7302/1571
Vagistat-1 (Tioconazole): Side Effects, Interactions, Warning, Dosage & Uses  Vagistat-1 (Tioconazole): Side Effects, Interactions, Warning, Dosage & Uses
... is intended for intravaginal administration only. Applicators should be opened just prior to administration to prevent ... These effects did not occur following intravaginal administration of approximately 10 mg/kg/day in a 2% cream. There was no ... DOSAGE AND ADMINISTRATION. VAGISTAT-1 (tioconazole) has been found to be effective as a single- dose treatment for vulvovaginal ... Administration of VAGISTAT-1 (tioconazole) just prior to bedtime may be preferred. The VAGISTAT-1 (tioconazole) ointment base ...
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ACAM Integrative Medicine Blog - American College for Advancement in Medicine (ACAM)  ACAM Integrative Medicine Blog - American College for Advancement in Medicine (ACAM)
Pharmacokineticsfollowing intravaginal administration. Eur J DrugMetab Pharmacokinet 1998;23:391-396.. 66. Cicinelli E, Nahoul ... Forms of Administration. The base of a cream, gel, or suppository can also affect absorption. In a study of topical ... Routes of Administration. Many different routes of delivery are available for natural hormones, including oral, transdermal ( ... The route of administration can confer differences in absorption,metabolic pathway, and bioavailability. In general,the oral ...
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Patent US6086856 - System for delivering foamed oral hygiene compositions - Google Patents  Patent US6086856 - System for delivering foamed oral hygiene compositions - Google Patents
The foams may be used for oral, cutaneous or intravaginal administration. The surfactants may be ionic or preferably nonionic. ... The dispensed foam is suitable for self-administration of the anti-plaque formulation. ...
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Management of Spontaneous Abortion - - American Family Physician  Management of Spontaneous Abortion - - American Family Physician
Expectant management of missed spontaneous abortion has variable success rates, but medical therapy with intravaginal ... Intravaginal administration of misoprostol causes less diarrhea than oral administration.27. Patient preferences should be ... Expectant management of missed spontaneous abortion has variable success rates, but medical therapy with intravaginal ...
more infohttps://www.aafp.org/afp/2005/1001/p1243.html
Using Progestins in Clinical Practice - American Family Physician  Using Progestins in Clinical Practice - American Family Physician
... has sustained-release properties that were not available in the original intravaginal preparations. Intravaginal administration ... Fanchin R, De Ziegler D, Bergeron C, Righini C, Torrisi C, Frydman R. Transvaginal administration of progesterone. Obstet ... Battino S, Ben-Ami M, Geslevich Y, Weiner E, Shalev E. Factors associated with withdrawal bleeding after administration of oral ... Bioavailability of progesterone with different modes of administration. J Reprod Med. 1987;32:443-8.... ...
more infohttps://www.aafp.org/afp/2000/1015/p1839.html
  • In order to deplete the local phagocyte population, 10 μl of clodronate liposomes was instilled intravaginally (ivag) and 250 μl of clodronate liposomes was injected i.v. on days -4 and -1 prior to intravaginal challenge by HSV-2 on day 0. (liposomes.org)
  • The fact that humanized BLT mice are susceptible to intravaginal infection makes this system an excellent candidate for preclinical evaluation of both microbicides and pre-exposure prophylactic regimens. (nih.gov)
  • The only oral azole agent approved for this indication by the US Food and Drug Administration (FDA) is fluconazole, which also achieves a high cure rate. (medscape.com)
  • 2.4 First aid measures and management principles In case of oral overdosage the common measures to limit the absorption of the drug from gastrointestinal tract, such as emesis, gastric lavage or administration of activated charcoal, should be performed, if patient seen early after ingestion. (intox.org)
  • The utility of humanized mice to study intravaginal HIV-1 transmission is particularly highlighted by the demonstration that pre-exposure prophylaxis can prevent intravaginal HIV-1 transmission in the BLT mouse model. (nih.gov)
  • Pre-exposure Prophylaxis Prevents Intravaginal HIV-1 Transmission in Humanized BLT Mice(A) Kaplan-Meier plot of the time course to plasma antigenemia conversion following intravaginal HIV-1 exposure in BLT mice with or without the 7-d pre-exposure regimen of FTC/TDF (administered once daily starting 48 h prior to intravaginal inoculation). (nih.gov)
  • In (D), note that in seven of eight tested BLT mice, a single exposure to HIV-1 led to intravaginal transmission and an initial drop, with subsequent stabilization, in the levels of peripheral blood CD4+ human T cells. (nih.gov)
  • There is also clear evidence that administration of DES in large doses during pregnancy increases the subsequent risk of breast cancer and that DES increases the risk of testicular cancer in males exposed in utero . (inchem.org)
  • Direct instillation of clodronate liposomes into the vagina has been reported in only 1 paper and until these results were published, it was only an assumption that local vaginal phagocytes (macrophages and dendritic cells) could be depleted by direct intravaginal instillation of clodronate liposomes. (liposomes.org)
  • The composition is administered by topical or local administration to the uterus or vaginal tissues of a women in need thereof, and contains an. (google.com)