Glycyrrhetinic Acid: An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.Administration, Intranasal: Delivery of medications through the nasal mucosa.Glycyrrhizic Acid: A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.Glycyrrhiza: A genus of leguminous herbs or shrubs whose roots yield GLYCYRRHETINIC ACID and its derivative, CARBENOXOLONE.Nasal Mucosa: The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.Glycyrrhiza uralensis: A plant species of the family FABACEAE.11-beta-Hydroxysteroid Dehydrogenases: Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can utilize either NAD or NADP as cofactors.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Equipment Design: Methods of creating machines and devices.Spectrophotometry, Atomic: Spectrophotometric techniques by which the absorption or emmision spectra of radiation from atoms are produced and analyzed.Beclomethasone: An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.Administration, Intranasal: Delivery of medications through the nasal mucosa.Androstadienes: Derivatives of the steroid androstane having two double bonds at any site in any of the rings.Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Administration, Inhalation: The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.Anti-Asthmatic Agents: Drugs that are used to treat asthma.Bronchodilator Agents: Agents that cause an increase in the expansion of a bronchus or bronchial tubes.Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Adrenal Cortex HormonesAdministration, Intranasal: Delivery of medications through the nasal mucosa.Thymidine Kinase: An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.Simplexvirus: A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.Ganciclovir: An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.Congresses as Topic: Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.Societies, Medical: Societies whose membership is limited to physicians.Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)Tropism: The directional growth of an organism in response to an external stimulus such as light, touch, or gravity. Growth towards the stimulus is a positive tropism; growth away from the stimulus is a negative tropism. (From Concise Dictionary of Biology, 1990)Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.H-Y Antigen: A sex-specific cell surface antigen produced by the sex-determining gene of the Y chromosome in mammals. It causes syngeneic grafts from males to females to be rejected and interacts with somatic elements of the embryologic undifferentiated gonad to produce testicular organogenesis.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Skin Transplantation: The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.gp100 Melanoma Antigen: A melanosome-associated protein that plays a role in the maturation of the MELANOSOME.Administration, Intranasal: Delivery of medications through the nasal mucosa.Immune Tolerance: The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.Dendritic Cells: Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).Transplantation Tolerance: An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Mice, Inbred C57BLAdministration, Intranasal: Delivery of medications through the nasal mucosa.Immunologic Memory: The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus.Respiratory Syncytial Viruses: A group of viruses in the PNEUMOVIRUS genus causing respiratory infections in various mammals. Humans and cattle are most affected but infections in goats and sheep have also been reported.CD8-Positive T-Lymphocytes: A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.Respiratory Syncytial Virus Infections: Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Vaccination: Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.Respiratory Syncytial Virus, Human: The type species of PNEUMOVIRUS and an important cause of lower respiratory disease in infants and young children. It frequently presents with bronchitis and bronchopneumonia and is further characterized by fever, cough, dyspnea, wheezing, and pallor.Interferon-gamma: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.Mice, Inbred C57BLMacaca radiata: A species of macaque monkey that mainly inhabits the forest of southern India. They are also called bonnet macaques or bonnet monkeys.Nasal Sprays: Pharmacologic agents delivered into the nostrils in the form of a mist or spray.Administration, Intranasal: Delivery of medications through the nasal mucosa.Sperm Count: A count of SPERM in the ejaculum, expressed as number per milliliter.Norethindrone: A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.Testosterone: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.Cryoanesthesia: ANESTHESIA achieved by lowering either BODY TEMPERATURE (core cooling) or SKIN TEMPERATURE (external cooling).Spermatogenesis-Blocking Agents: Chemical substances which inhibit the process of spermatozoa formation at either the first stage, in which spermatogonia develop into spermatocytes and then into spermatids, or the second stage, in which spermatids transform into spermatozoa.Estradiol: The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.Semen: The thick, yellowish-white, viscid fluid secretion of male reproductive organs discharged upon ejaculation. In addition to reproductive organ secretions, it contains SPERMATOZOA and their nutrient plasma.
(1/2093) Complement fixation titers in cattle following intranasal inoculation of Hemophilus somnus.

Five bulls were inoculated intranasally with a live culture of Hemophilus somnus originally isolated from a clinical case of Hemophilus septicemia. Preinoculation and postinoculation blood samples were taken at weekly intervals for nine weeks for measuring complement fixation titers and daily postinoculation temperatures were taken for one week. Three animals had transient fever and slight lethargy was observed in two animals had a transitory rise in complement fixation titers in the second to fifth weeks postexposure while one animal which had been seronegative on preinoculation testing produced little serological response to the organism. The experiment demonstrated that the nasal instillation of young cattle using an originally pathogenic H. somnus isolate is capable of stimulating only transitory complement fixation antibody titer.  (+info)

(2/2093) Zonula occludens toxin is a powerful mucosal adjuvant for intranasally delivered antigens.

Zonula occludens toxin (Zot) is produced by toxigenic strains of Vibrio cholerae and has the ability to reversibly alter intestinal epithelial tight junctions, allowing the passage of macromolecules through the mucosal barrier. In the present study, we investigated whether Zot could be exploited to deliver soluble antigens through the nasal mucosa for the induction of antigen-specific systemic and mucosal immune responses. Intranasal immunization of mice with ovalbumin (Ova) and recombinant Zot, either fused to the maltose-binding protein (MBP-Zot) or with a hexahistidine tag (His-Zot), induced anti-Ova serum immunoglobulin G (IgG) titers that were approximately 40-fold higher than those induced by immunization with antigen alone. Interestingly, Zot also stimulated high anti-Ova IgA titers in serum, as well as in vaginal and intestinal secretions. A comparison with Escherichia coli heat-labile enterotoxin (LT) revealed that the adjuvant activity of Zot was only sevenfold lower than that of LT. Moreover, Zot and LT induced similar patterns of Ova-specific IgG subclasses. The subtypes IgG1, IgG2a, and IgG2b were all stimulated, with a predominance of IgG1 and IgG2b. In conclusion, our results highlight Zot as a novel potent mucosal adjuvant of microbial origin.  (+info)

(3/2093) The posterior nasal nerve plays an important role on cardiopulmonary reflexes to nasal application of capsaicin, distilled water and l-menthol in anesthetized dogs.

The sensory innervation of the cardiopulmonary reflexes to nasal application of capsaicin (CAPS), distilled water (DW) and l-menthol (LM) was studied in anesthetized dogs breathing through tracheostomy. A marked cardiopulmonary reflex was observed by CAPS and DW into the nasal cavity, while a prolongation of expiration was induced by LM. All these reflexes were significantly decreased by bilateral section of the posterior nasal nerve (PNN) and completely abolished by topical nasal anesthesia with lidocaine. Responses of the whole nerve activity of the PNN to these substances corresponded to the magnitude of the reflexes. These results indicate that PNN afferents play an important role on the reflex elicitation of the noxious, water and cold stimuli from the nasal cavity.  (+info)

(4/2093) Protective immune response against Streptococcus pyogenes in mice after intranasal vaccination with the fibronectin-binding protein SfbI.

Despite the significant impact on human health of Streptococcus pyogenes, an efficacious vaccine has not yet been developed. Here, the potential as a vaccine candidate of a major streptococcal adhesin, the fibronectin-binding protein SfbI, was evaluated. Intranasal immunization of mice with either SfbI alone or coupled to cholera toxin B subunit (CTB) triggered efficient SfbI-specific humoral (mainly IgG) and lung mucosal (14% of total IgA) responses. CTB-immunized control mice were not protected against challenge with S. pyogenes (90%-100% lethality), whereas SfbI-vaccinated animals showed 80% and 90% protection against homologous and heterologous challenge, respectively. Multiple areas of consolidation with diffused cellular infiltrates (macrophages and neutrophils) were observed in lungs from control mice; the histologic structure was preserved in SfbI-vaccinated animals, which occasionally presented focal infiltrates confined to the perivascular, peribronchial, and subpleural areas. These results suggest that SfbI is a promising candidate for inclusion in acellular vaccines against S. pyogenes.  (+info)

(5/2093) Central nervous system effects of intranasally administered insulin during euglycemia in men.

Insulin receptors have been detected in several structures of the brain, yet the biological significance of insulin acting on the brain remains rather unclear. In humans, direct central nervous effects of insulin are difficult to distinguish from alterations in neuronal functions because of insulin-induced decrease in blood glucose levels. Since several intranasally administered viruses, peptides, and hormones have been shown to penetrate directly from the nose to the brain, we tested whether insulin after intranasal administration likewise has access to the brain. After a 60-min baseline period, insulin (20 IU H-Insulin 100 Hoechst) or vehicle (2.7 mg/ml m-Cresol) was intranasally administered every 15 min to 18 healthy subjects according to a double-blind within-subject crossover design. Auditory-evoked potentials (AEP) indexing cortical sensory processing were recorded while the subjects performed a vigilance task (oddball paradigm) during the baseline phase and after 60 min of intranasal treatment with insulin or placebo. Blood glucose and serum insulin levels were not affected by intranasal insulin. Compared with placebo, intranasal administration of insulin reduced amplitudes of the N1 (P < 0.005) and P3 (P < 0.02) components of the AEP and increased P3 latency (P < 0.05). The reduction in P3 amplitude was most pronounced over the frontal recording site (2.42 +/- 1.00 vs. 4.92 +/- 0.79 microV, P < 0.0005). At this site, after insulin administration, a broad negative shift developed in the AEP between 280 and 500 ms poststimulus (area under the curve -166.0 +/- 183.8 vs. 270.8 +/- 138.7 microV x ms after placebo, P < 0.01). The results suggest that after intranasal administration, insulin directly enters the brain and exerts distinct influences on central nervous functions in humans.  (+info)

(6/2093) Lesions and transmission of experimental adenovirus hemorrhagic disease in black-tailed deer fawns.

Adenovirus infection was the cause of an epizootic of hemorrhagic disease that is believed to have killed thousands of mule deer (Odocoileus hemionus) in California during the latter half of 1993. A systemic vasculitis with pulmonary edema and hemorrhagic enteropathy or a localized vasculitis associated with necrotizing stomatitis/pharyngitis/glossitis or osteomyelitis of the jaw were common necropsy findings in animals that died during this epizootic. To study transmission of adenovirus infection in deer and susceptibility of black-tailed deer (Odocoileus hemionus columbianus) fawns to adenovirus infection, six 3-6-month-old black-tailed fawns were divided into two treatment groups. One group was inoculated intravenously and the other group was inoculated through the mucous membranes of the eyes, nose and mouth with purified adenovirus. Each treatment group also included two additional fawns (four total) that were not inoculated but were exposed to inoculated animals (contact animals). One fawn served as a negative control. Between 4 and 16 days postinoculation, 8/10 fawns developed systemic or localized infection with lesions identical to lesions seen in animals with natural disease that died during the epizootic. Transmission was by direct contact, and the route of inoculation did not affect the incubation period or the distribution of the virus (systemic or the localized infection). Immunohistochemical analysis using polyclonal antiserum against bovine adenovirus type 5 demonstrated staining in endothelial cells of vessels in numerous tissues in animals with systemic infection and endothelial staining only in vessels subtending necrotic foci in the upper alimentary tract in animals with the localized form of the disease. All inoculated or exposed animals had staining in the tonsillar epithelium. Transmission electron microscopic examination of lung and ileum from two fawns with pulmonary edema and hemorrhagic enteropathy demonstrated endothelial necrosis and adenovirus virions in endothelial cell nuclei. Adenovirus was reisolated in black-tailed deer pulmonary artery endothelial cells using lung homogenate of the first fawn that developed systemic adenovirus infection. Serum virus neutralization test results suggest that this deer adenovirus is a new serotype.  (+info)

(7/2093) Intranasally inoculated Mycoplasma hyorhinis causes eustachitis in pigs.

Specific-pathogen-free pigs were experimentally inoculated with Mycoplasma hyorhinis, Pasteurella multocida, or both bacterial isolates to evaluate the role of these bacteria in the pathogenesis of otitis media. Six pigs were inoculated intranasally with 4.4 X 10(8) colony-forming units (CFU) of M. hyorhinis. Twenty-one days later, three of these six pigs were inoculated intranasally with 5.0 X 10(8) CFU of P. multocida. Three additional pigs were also inoculated intranasally at the time with P. multocida alone. Two pigs served as uninoculated controls. Seven days later, all pigs were euthanatized. Histologically, subacute inflammation was found in 10 auditory tubes of six pigs and two tympanic cavities of two pigs inoculated with M. hyorhinis. Immunohistochemically, M. hyorhinis antigens were detected on the luminal surface of eight of 10 inflamed auditory tubes, and ultrastructural examination confirmed mycoplasmal organisms in two pigs. M. hyorhinis was isolated from the inflamed tympanic cavities of two pigs. None of the pigs inoculated only with P. multocida had otitis, and P. multocida was not isolated from the tympanic cavity. These findings indicate that M. hyorhinis can cause eustachitis but rarely otitis media in specific-pathogen-free pigs.  (+info)

(8/2093) Comparison of intranasal triamcinolone acetonide with oral loratadine in the treatment of seasonal ragweed-induced allergic rhinitis.

A double-blind, randomized, multicenter, parallel-group controlled study compared the efficacy and safety of intranasal triamcinolone acetonide (220 micrograms/day) and oral loratadine (10 mg/day) in patients with at least two seasons of ragweed-induced seasonal allergic rhinitis. A 28-day screening period, including a 5-day baseline period, preceded a 4-week treatment period. Reduction in rhinitis symptom scores was evident in both groups as early as day 1, with no significant between-group differences during week 1. At weeks 2, 3, and 4, patients treated with triamcinolone acetonide were significantly (P < 0.05) more improved in total nasal score, nasal itch, nasal stuffiness, and sneezing than were patients treated with loratadine. At weeks 3 and 4, rhinorrhea and ocular symptoms were significantly (P < 0.05) more improved from baseline among triamcinolone acetonide patients compared with loratadine patients. There was no significant between-group difference in relief from postnasal drip at any time point. Physicians' global evaluations significantly (P = 0.002) favored triamcinolone acetonide at the final visit, with moderate to complete relief of symptoms attained by 68% of triamcinolone acetonide patients and 59% of loratadine patients. Over the 4-week treatment period, triamcinolone acetonide patients had significantly greater improvement in total nasal score, nasal itch, nasal stuffiness, sneezing, and ocular symptoms. Both treatments were well tolerated, with headache being the most frequently reported drug-related adverse effect in both the triamcinolone acetonide (15%) and loratadine (11%) groups. These results indicate that triamcinolone acetonide is more effective than oral loratadine in relieving the symptoms of ragweed-induced seasonal allergic rhinitis.  (+info)

*  Nasal administration
Intranasal midazolam is found to be highly effective in acute episodes of seizures in children. Recently, the upper part of the ... Nasal administration is a route of administration in which drugs are insufflated through the nose. It can be a form of either ... Nasal administration can therefore be used as an alternative to oral administration of for example tablets and capsules if a ... the variability in the amount absorbed after nasal administration should be comparable to that after oral administration. The ...
*  Examorelin
Laron, Z.; Frenkel, J.; Deghenghl, R.; Anin, S.; Klinger, B.; Siibergeld, A. (1995). "Intranasal administration of the GHRP". ... Frenkel, J.; Silbergeld, A.; Deghenghi, R.; Laron, Z. (1995). "Short Term Effect of Intranasal Administration of Hexarelin". ... intranasal, and oral administration in man". J Clin Endocrinol Metab. 78 (3): 693-8. doi:10.1210/jcem.78.3.8126144. PMID ... "Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone ...
*  Oxytocin
... since intranasal administration of oxytocin also increases envy and Schadenfreude. Individuals who receive an intranasal dose ... Theodoridou A, Penton-Voak IS, Rowe AC (2013). "A direct examination of the effect of intranasal administration of oxytocin on ... Shamay-Tsoory SG, Fischer M, Dvash J, Harari H, Perach-Bloom N, Levkovitz Y (November 2009). "Intranasal administration of ... Fischer-Shofty M, Shamay-Tsoory SG, Harari H, Levkovitz Y (January 2010). "The effect of intranasal administration of oxytocin ...
*  Relationship counseling
Shamay-Tsoory SG, Fischer M, Dvash J, Harari H, Perach-Bloom N, Levkovitz Y (November 2009). "Intranasal administration of ... Some researchers have argued oxytocin has a general enhancing effect on all social emotions, since intranasal administration of ... 19 (7). Wudarczyk, O. A.; Earp, B. D.; Guastella, A; Savulescu, J (2013). "Could intranasal oxytocin be used to enhance ...
*  Estrogen (medication)
Rigg LA, Milanes B, Villanueva B, Yen SS (1977). "Efficacy of intravaginal and intranasal administration of micronized ... This route of administration is thus preferred in women with a history of thrombo-embolic disease. Estrogen is also used in the ... However, such risks have been found to vary depending on the type of estrogen or progestogen and the route of administration. ... It was only until 1941 when estrogen therapy was finally approved by the Food and Drug Administration (FDA) for the treatment ...
*  Oxytocin (medication)
Fischer-Shofty M, Shamay-Tsoory SG, Harari H, Levkovitz Y (2010). "The effect of intranasal administration of oxytocin on fear ... "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology. 37 (9): 1582-6. doi:10.1016/j. ... "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro ... Intranasal oxytocin has a central duration of at least 2.25 hours and as long as 4 hours. Oral: Oxytocin is destroyed in the ...
*  Jason Diamond
Comparing Intranasal Administration to Intramuscular Administration in Healthy Human Volunteers." University of Kentucky ... "A single dose, Open Label, Randomized Three Way Crossover, Bioavailability Study of 1.0 mg and 2.0 Intranasal Butorphanol ... "A single Dose, Randomized Two Period Crossover Pharmacokinetic Study of 2.0 mg Intranasal Hydromorphone Hydrochloride In ...
*  Methamphetamine
... is also well absorbed following inhalation and following intranasal administration. It is distributed to most ... Methamphetamine is also well absorbed following inhalation and following intranasal administration. Due to the high ... Repeated administration or self administration of METH has been shown to upregulate σ-1 receptor protein and mRNA in various ... The lack of effect of administration of neomycin to one patient indicates that the hydroxylation occurs in body tissues. ... a ...
*  Doxylamine
The bioavailability of doxylamine is 24.7% for oral administration and 70.8% for intranasal administration. The Tmax of ... "Comparative pharmacokinetics of single doses of doxylamine succinate following intranasal, oral and intravenous administration ... Doxylamine succinate is generally safe for administration to healthy adults. The median lethal dose (LD50) is estimated to be ...
*  Buserelin
Its bioavailability is 2.5 to 3.3% by intranasal administration and 70% by subcutaneous injection. The plasma protein binding ... With chronic administration of buserelin however, the GnRH receptor becomes desensitized and completely stops responding both ... The elimination half-life of buserelin regardless of route of administration is about 72 to 80 minutes. Buserelin and its ... Trabant H, Widdra W, de Looze S (1990). "Efficacy and safety of intranasal buserelin acetate in the treatment of endometriosis ...
*  NS1 influenza protein
Vincent AL, Ma W, Lager KM, Janke BH, Webby RJ, Garcia-Sastre A, Richt JA (2007). "Efficacy of intranasal administration of a ...
*  Selank
"Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo". Doklady Biological ...
*  Demyelinating disease
Clausi, M.G.; Paez, P.M.; Campagnoni, A.T.; Pasquini, L.A.; Pasquini, J.M.; Ahmadiani, A. (2012). "Intranasal administration of ... It has been shown that intranasal administration of aTf (apotransferrin) can protect myelin and induce remyelination. Much of ...
*  Oxytocin treatment for postpartum depression
Increased levels of OT can be found in salivary samples after intranasal administration of the neuropeptide. Salivary OT levels ... Weisman, O., Zagoory-Sharon, O., & Feldman, R. (2012). Intranasal oxytocin administration is reflected in human saliva. ... Intranasal (IN) administration, as opposed to more conventional routes, such as oral or intravenous infusion, offers an ... A review of 38 randomized and controlled trials suggests that short-term use of intranasal oxytocin appears to have few side- ...
*  Von Willebrand disease
Desmopressin is also available as a preparation for intranasal administration (Stimate) and as a preparation for intravenous ... Administration of the latter is also associated with increased risk of venous thromboembolic complications. Blood transfusions ... Administration of ethinylestradiol diminishes the secretion of luteinizing hormone and follicle-stimulating hormone from the ... administration. Recently, the FDA has approved the use of Baxalta's Vonvendi. This is the first recombinant form of vWF. The ...
*  Biological half-life
In addition, also unlike the case of peripheral administration, intranasal oxytocin has a central duration of at least 2.25 ... "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology. 37 (9): 1582-6. doi:10.1016/j. ... "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro ... Thus the fall in plasma concentration after the administration of a single dose is described by the following equation: C t = C ...
*  Anosmia
Preventing Anosmia from Intranasal Zinc Administration[unreliable medical source?] Maruyama T, Yasuda S, Odashiro K, Kaji Y, ... Intranasal drug use Samter's triad also known as AERD (aspirin exacerbated respiratory disease) Foster Kennedy syndrome Cadmium ... On June 16, 2009, the US Food and Drug Administration sent a warning letter to Matrixx Initiatives, manufacturer of an over-the ... Sarcoidosis Zinc-based intranasal cold products, including remedies labelled as "homeopathic" Chronic atrophic rhinitis Paget's ...
*  Yakult
September 12, 2014). "Effect of Intranasal Administration ofLactobacillus casei Shirota on Influenza Virus Infection of Upper ...
*  Dennis S. Charney
... owns patents in dopamine and noradrenergic reuptake inhibitors in treatment of schizophrenia and in intranasal administration ... Member, Food and Drug Administration Psychopharmacologic Drug Advisory Committee Editorial Committee, Biological Psychiatry, a ...
*  Klebsiella pneumoniae
... or intranasal administration of phages in laboratory tests. Resistance to phages is not likely to be as troublesome as to ...
*  Let-7 microRNA precursor
Intranasal administration of let-7 has already been found effective in reducing tumor growth in a transgenic mouse model of ...
*  Remifentanil
Levine, A. I., & Bryson, E. O. (2010). Intranasal self-administration of remifentanil as the foray into opioid abuse by an ... Panlilio, L. V., & Schindler, C. W. (2000). Self-administration of remifentanil, an ultra-short acting opioid, under continuous ... Comparison of remifentanil or fentanyl administration during isoflurane anesthesia for coronary artery bypass surgery. Med Sci ... US Food and Drug Administration. (2010). Orange book: approved drug products with therapeutic equivalence evaluations. Silver ...
*  Hiccup
The administration of intranasal vinegar was found to ease the chronic and severe hiccups of a three-year-old Japanese girl. ... "食用酢の点鼻による吃逆の治療 Hiccup treated by administration of intranasal vinegar". No to Hattatsu. Brain and Development (in Japanese). 39 ... The Food and Drug Administration approved the vagus nerve stimulator in 1997 as a way to control seizures in some patients with ...
*  Pregnenolone
"Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration". Eur ... Unlike the case of oral administration, transdermal administration of 30 mg/day pregnenolone cream has not been found to affect ... Oral administration of 50 or 100 mg pregnenolone has been found to have minimal or negligible effect on urinary levels of ... In further research by their group, a single 400 mg dose of oral pregnenolone at 3 hours post-administration was found to ...
*  Allopregnanolone
"Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration". Eur ... In accordance, acute administration of low doses of micronized progesterone (which reliably elevates allopregnanolone levels), ... "Investigations on changes in ¹³C/¹²C ratios of endogenous urinary steroids after pregnenolone administration". Drug Test Anal. ... "Urinary marker of oral pregnenolone administration". Steroids. 70 (3): 179-83. doi:10.1016/j.steroids.2004.12.007. PMID ...
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... with rectal administration yielding the same results; intranasal varies between individuals with a mean of 46%. Taken orally, ... Therapeutic Goods Administration (June 2008). Standard for the uniform scheduling of drugs and poisons no. 23 (PDF). Canberra: ... Drug Enforcerment Administration. Retrieved 23 November 2015. "DEA Diversion Control CSA". US Dept of Justice - DEA. Retrieved ... In the United Kingdom, it is available in 10 mg/mL and 50 mg/mL formulation for intramuscular or intravenous administration. ...
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There are several methods of administration, including parenteral and intranasal. However, the intranasal method has been ... Several intranasal vaccines have been developed that contain canine adenovirus in addition to B bronchiseptica and canine- ... Administration of B. bronchiseptica and canine-parainfluenza vaccines may then be continued routinely, especially during ... Adverse effects of vaccinations are mild, but the most common effect observed up to 30 days after administration is nasal ...
A portion of nasal venous blood is indeed diverted to intracranial veins via direct communication between the ophthalmic veins, pterygoid plexus, and cavernous sinus, but the other portion of blood is drained extracranially by facial veins directly into the IJV. Stated differently, the cavernous sinus receives only a portion of xenon-enriched blood from the nasal space, but the IJV collects almost all the blood from it. Therefore, a steady concentration of xenon in the IJV 10 min after intranasal application in volunteers is more a reflection of saturation of the nasal mucosa and nasal (not cranial) venous vascular beds with xenon. The actual concentration of xenon in the cavernous sinus is probably less than 500 nl/ml because the latter collects only a portion of nasal venous blood. Furthermore, although the cavernous sinus does communicate with basilar and superficial cortical veins, it is a "blood collector" that is ultimately drained into the IJV, and retrograde flow of xenon-containing ...
Nasal administration is a route of administration in which drugs are insufflated through the nose. It can be a form of either topical administration or systemic administration, as the drugs thus locally delivered can go on to have either purely local or systemic effects. Nasal sprays are locally acting drugs such as decongestants for cold and allergy treatment, whose systemic effects are usually minimal. Examples of systemically active drugs available as nasal sprays are migraine drugs, nicotine replacement, and hormone treatments. The nasal cavity is covered by a thin mucosa which is well vascularised. Therefore, a drug molecule can be transferred quickly across the single epithelial cell layer directly to the systemic blood circulation without first-pass hepatic and intestinal metabolism. The effect is often reached within 5 min for smaller drug molecules. Nasal administration can therefore be used as an alternative to oral administration of for example tablets and capsules if a fast effect is ...
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The blood-brain barrier is a substantial obstacle for delivering anticancer agents to brain tumors, and new strategies for bypassing it are sorely needed for brain tumor therapy. Intranasal delivery provides a practical, noninvasive method for delivering therapeutic agents to the brain. Intranasal application of nano-sized micelles that have been modified with Tat peptide facilitates brain delivery of fluorescent model materials. In this study, we evaluated a nose-to-brain delivery system for brain tumor therapy. We nasally administered the anti-tumor drug camptothecin (CPT) in solution and in methoxy poly(ethylene glycol) (MPEG)/poly(e-caprolactone) (PCL) amphiphilic block copolymers (MPEG-PCL) and cell penetrating peptide, Tat analog-modified MPEG-PCL (MPEG-PCL-Tat) MPEG-PCL-Tat to rats bearing intracranial glioma tumors and quantified the cytotoxicity against glioma cells, and the therapeutic effects. CPT-loaded MPEG-PCL-Tat micelles showed higher cytotoxicity than CPT-loaded MPEG-PCL. CPT-free MPEG
The findings support the hypothesis that the frequency of severe adverse events following intranasal administration of NeuroEPO would be less than 10% since no severe events occurred. This is in accordance with the literature since the use of rHu-EPO in healthy subjects apparently does not affect physiological indexes and its use is safe for experimental purposes [34].. The current first NeuroEPO-in-human trial demonstrated the absence of hematopoietic activity according to the safety profile. This result is expected due to this EPO possesses a low content of sialic acid, a component that plays a key role in the preservation of EPO structure thereby avoiding its destruction by the liver. Low sialic acid content rHu-EPO molecules are rapidly metabolized by the liver and therefore eliminated without being able to exert their hematopoietic action [3]. This is the main expected safety benefit of NeuroEPO and has already been demonstrated in laboratory animals since the product did not modify ...
Ischemic stroke-induced neuronal cell death results in the permanent disabling of brain function. Apoptotic mechanisms are thought to play a prominent role in neuronal injury and ample evidence implicates Fas signaling in mediating cell death. In this study, we describe the neuroprotective effects of a Fas-blocking peptide (FBP) that by obstructing Fas signaling in cerebral ischemia inhibits apoptosis. Using an intranasal administration route in a rat model of focal cerebral ischemia, we demonstrate that nose-to-brain delivery of FBP after middle cerebral artery occlusion (MCAO) surgery results in the delivery and retention of FBP in Fas-expressing ischemic areas of the brain. A single intranasal administration of 2 mg/kg FBP resulted in significantly reduced neuronal cell death by inhibiting Fas-mediated apoptosis leading to decreased infarct volumes, reduced neurologic deficit scores and recovery from cerebral ischemia. Intranasally delivered FBP might be a promising strategy for the treatment of
One of the major challenges for the development of an HIV vaccine is to induce potent virus-specific immune responses at the mucosal surfaces where transmission of virus occurs. Intranasal delivery of classical vaccines has been shown to induce good mucosal antibody responses, but so far for genetic vaccines the success has been limited. This study shows that young individuals are sensitive to nasal immunization with a genetic vaccine delivered in a formulation of a lipid adjuvant, the Eurocine N3. Intranasal delivery of a multiclade/multigene HIV-1 genetic vaccine gave rise to vaginal and rectal IgA responses as well as systemic humoral and cellular responses. As electroporation might become the preferred means of delivering genetic vaccines for systemic HIV immunity, nasal delivery by droplet formulation in a lipid adjuvant might become a means of priming or boosting the mucosal immunity. © 2008 Elsevier Ltd. All rights reserved.. ...
8. Ellis, J., Gow, S., West, K., Waldner, C., Rhodes, C., Mutwiri, G., and Rosenberg, H.; Response of calves to challenge esposure with virulent bovine respiratory syncytial virus following intranasal administration of vaccines formulated for parenteral administraction. 2007. JAVMA. 230, 2:233-244 ...
Manganese has been used as a functional contrast agent in many pre-clinical MRI studies. However, Mn2+ cellular toxicity limits its use as contrast agent in humans to low concentrations. We studied 51Mn (t1/2=46.2min) and 52Mn (t1/2=5.6days) for PET imaging in rats and monkeys. We show that manganese radiotracers give similar contrast to Mn2+ in MRI with accumulation in different tissues following systemic infusion even at the low concentration used. 52Mn-PET can trace olfactory pathways in the brain following intranasal administration in monkey, similar to MEMRI in rodents. Manganese PET should allow using the unique properties of Mn in clinical studies ...
Patients with Alzheimer disease (AD) and amnestic mild cognitive impairment (aMCI), who were treated with intranasal insulin did better on cognitive and functional tests than their untreated counterparts, results of a pilot study indicate.
Objective: Neural stem cells (NSC) have an inherent brain tumor tropism that can be exploited for targeted delivery of therapeutic genes to invasive gliomas. Here, we demonstrate that the non-invasive intranasal administration of tumor-targeting NSC is able to deliver a novel suicide gene (TK007) to intracerebrally growing human glioblastoma xenografts.. Method: Murine NSC were genetically modified to express the novel herpes simplex virus thymidine kinase variant (TK007). The biological activity of the NSC-mediated TK007/ganciclovir (GCV) system was assessed in cell survival and bystander assays using various human glioma cell lines. Therapeutic effects of intratumoral (3x105 cells) and intranasal (1.5x106) NSC-TK007 application alone and the sequential combination of both was tested using an intracranial U87 human glioblastoma model in nude mice. All animals received 50 mg/kg GCV i.p. for five consecutive days. Two control groups received either NaCl instead of GCV or NSC containing the empty ...
Cytomegalovirus vectors are promising delivery vehicles for vaccine strategies that aim to elicit effector CD8+ T cells. To determine how the route of immunization affects CD8+ T cell responses in the lungs of mice vaccinated with a murine cytomegalovirus vector expressing the respiratory syncytial virus matrix (M) protein, we infected CB6F1 mice via the intranasal or intraperitoneal route and evaluated the M-specific CD8+ T cell response at early and late time points. We found that intranasal vaccination generated robust and durable tissue-resident effector and effector memory CD8+ T cell populations that were undetectable after intraperitoneal vaccination. The generation of these antigen-experienced cells by intranasal vaccination resulted in earlier T cell responses, interferon gamma secretion, and viral clearance after respiratory syncytial virus challenge. Collectively, these findings validate a novel approach to vaccination that emphasizes the route of delivery as a key determinant of ...
Intermittent exposure episode is a series of fewer than four sequential prescriptions for an intranasal steroid other than Flixonase with gaps of no more than 60 days between any two. Sub-chronic use episode is a series of at least four and not more than eight sequential prescriptions for an intranasal steroid other than Flixonase with gaps of no more than 60 days between any two. Chronic use episode is a series of at least nine sequential prescriptions for an intranasal steroid other than Flixonase and gaps of no more than 60 days between any two. A span of at least 180 days must occur between the first and last prescription ...
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Professor Len Harrison from the institutes Immunology division and Professor Peter Colman and Dr Spiros Fourlanos from the hospitals Department of Diabetes and Endocrinology have demonstrated that the nasal insulin vaccine desensitises the human immune system, suppressing its reaction against insulin. Their research was published in the April issue of the journal Diabetes.. Their research provides proof-of-principle for the type 1 diabetes prevention trial, also called the intranasal insulin trial II (INIT II), which is being conducted in Australia and New Zealand and soon in Germany.. Previous research by Professor Harrison showed in laboratory mice that a nasal insulin vaccine was successful in preventing type 1 diabetes.. "These latest results encourage us that we are on the right track to finding a vaccine for type 1 diabetes," Professor Harrison said.. Type 1 diabetes occurs when the bodys immune system attacks and kills beta cells - the cells in the pancreas that produce insulin. ...
Because peptides are most often labile in the GI tract they are usually administered by injection. The principal fragment of interest, D-Leu-OB-3, has been shown to induce significant weight loss upon i.p injection, nasal administration and oral administration. A non-invasive format is preferred in terms of patient compliance, convenience, ease of self administration, and avoidance of needle stick injuries for patients or care givers. While intranasal administration of protein and peptide drugs has shown some limited success with small peptides such as desmopressin and calcitonin, Aegis Intravail® absorption enhancement agents provide unmatched bioavailabilities - bioavailabilities comparable to injection for small as well as much larger proteins. Our studies have shown that OB-3 peptide formulated with Intravail® excipients induces significant weight loss upon nasal administration with bioavailability comparable to injection approaching or exceeding 100% compared to s.c. injection. Intravail ...
Rheumatoid arthritis (RA) is a systemic autoimmune disease mediated by T cells. Collagen type II (CII) is one of the autoantigens associated with RA. CII263-272 is a predominant CII antigenic peptide that can induce T-cell activation upon binding to MHC and interaction with the appropriate T-cell receptor (TCR). Altered CII263-272 peptides with substitution of specific amino acids could bind to RA-associated HLA-DR4/1 with no T cell stimulating effects and could inhibit T cell activation in RA. We performed this study to evaluate the effect of mucosal administration and to explore the mechanism of the inhibitory effect of altered CII263-272 peptide (267Q A, 270K A and 271G A) on collagen induced arthritis (CIA). CIA was induced in Lewis rats by immunization with bovine CII. Altered CII263-272 peptide was given intranasally beginning from arthritis onset. Wild CII263-272 peptide or PBS was administered as controls. Therapeutic effects were evaluated by arthritis scores, body weight ...
OBJECTIVE Insulin in pancreatic β-cells is a target of autoimmunity in type 1 diabetes (T1D). In the NOD mouse model of T1D, oral or nasal administration of insulin induces immune tolerance to insulin and protects against autoimmune diabetes. Evidence for tolerance to mucosally administered insulin or other autoantigens is poorly documented in humans. Adults with recent-onset T1D in whom the disease process is subacute afford an opportunity to determine whether mucosal insulin induces tolerance to insulin subsequently injected for treatment. ...
Pneumonia can be produced in mice, which have not been previously prepared, by intranasal inoculation of broth cultures of certain strains of pneumococci.. Lesions which are quantitatively different can be produced in different breeds of mice by inoculation of the same type of pneumococcus. Similar inoculation of different types of pneumococci into one breed of mice results in lesions which are qualitatively different.. In general, these lesions are as follows: a diffuse pneumonia and an acute glomerular nephritis in unselected mice receiving Type I strains; a confluent pneumonia and a tubular nephritis in the case of Type II strains; and as result of Type III strains, an interstitial pneumonia with extensive gelatinous pleurisy, together with necrosis and abscess formation in the spleen and cervical lymph nodes. Resistant strains of mice with Type III pneumococci show slight changes in the lungs, but marked lesions in the spleen and cervical nodes, while susceptible mice with the same type of ...
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This study is a single center, randomized, double-blind, placebo-controlled, cross-over pilot study designed to assess the safety of intranasally (IN) delivered glulisine versus placebo in patients with DS. Subjects will be randomized into this cross-over study and within subject comparisons conducted between single treatment of intranasal insulin glulisine and single treatment of intranasal placebo. All subjects will also receive a single treatment of placebo prior to randomization to ensure adherence to study procedures ...
Before using this medicine, clear the nasal passages by blowing your nose. Then, with the nosepiece inserted into the nostril, aim the spray towards the inner corner of the eye.. In order for this medicine to help you, it must be used regularly as ordered by your doctor. This medicine usually begins to work in about 1 week (for dexamethasone), but up to 3 weeks may pass before you feel its full effects.. Use this medicine only as directed. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of absorption through the lining of the nose and the chance of unwanted effects.. Check with your doctor before using this medicine for nasal problems other than the one for which it was prescribed, since it should not be used on many bacterial, virus, or fungus nasal infections.. Save the inhaler that comes with beclomethasone or dexamethasone, since refill units may be available at lower cost.. ...
This trial will evaluate the efficacy and safety of FFNS110 mcg and 55 mcg once daily versus vehicle placebo aqueous nasal spray in chinese pediatric subjects
City Health Director Dr. Johnnie Lee said the MedImmune intranasal vaccine will only be administered to healthy 2- to 4-year-old children.|br/||br/|Because its an inhalant, the nasal vaccine can exacerbate some respiratory conditions, so only healthy children are eligible, Lee said.|br/||br/|By mid-December, the vaccine should be available for anyone who is interested.|br/||br/|Since the beginning of the year, the city has seen about 245 people with laboratory confirmed H1N1, though medical officials warn this is only the tip of the iceberg, because most people get better on their own, Stamford Hospitals director of infectious diseases, Dr. Michael Parry, said.|br/||br/|
The city health director Dr. Johnnie Lee said the MedImmune intranasal vaccine will only be administered to healthy 2- to 4-year-old children.|br/||br/|Because its an inhalant, the nasal vaccine can exacerbate some respiratory conditions, so only healthy children are eligible, Lee said.|br/||br/|By mid-December, the vaccine should be available for anyone who is interested.|br/||br/|Since the beginning of the year, the city has seen about 245 people with laboratory confirmed H1N1, though medical officials warn this is only the tip of the iceberg, because most people get better on their own, Stamford Hospitals director of infectious diseases Dr. Michael Parry said.|br/||br/|
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SHERMAN, TX -- The Grayson County Health Department will provide Flu Mist, the 2009 H1N1 influenza live, attenuated intranasal vaccine (LAIV/the nasal spray vaccine) to people 2 through 49 years of age who are not pregnant and do not have certain health conditions listed below.
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1999 - Flu-Avert™ developed in conjunction with Heska provided an intranasal vaccine for equine subtype 2 influenza virus. The modified-live virus vaccine was licensed in 1999 by the USDA. Work on maternal antibody interference by researchers in the department led to new recommendations for foal vaccination schedules by the American Association of Equine Practitioners. ...
Correction of the deficiency of early meal-time insulin secretion, using intravenous insulin in patients with Type 2 diabetes causes substantial improvement in post-prandial hyperglycaemia. The present study was designed to determine whether similar benefit would result from physiological supplementation using intranasal insulin delivery. Six patients with Type 2 diabetes were studied twice during a standard mixed meal. At the start of the meal they received a single intranasal spray containing either 15 units of insulin in 1% sodium glycocholate (adjuvant agent) or glycocholate alone (placebo) in a single-blind fashion. Intranasal insulin delivery resulted in rapid absorption of insulin with peak levels (92 +/- 8 (+/- SE) mU l-1) within 5-10 min. Peak insulin levels were at least equal to those in non-diabetic subjects, though occurring at an earlier time-point. However, no significant improvement in post-prandial hyperglycaemia was seen (peak blood glucose increment 4.9 +/- 0.6 vs 5.4 +/- 0.5 mmol l-1
Animal studies suggest that insulin action in the brain is involved in the regulation of peripheral insulin sensitivity. Whether this holds true in humans is unknown. Using intranasal application of insulin to the human brain, we studied impacts of brain insulin action on whole-body insulin sensitivity and mechanisms involved in this process.. Insulin sensitivity was assessed by hyperinsulinemic euglycemic glucose clamp, before and after intranasal application of insulin and placebo in randomized order in lean and obese men. After insulin spray application in lean, higher glucose infusion rate was necessary to maintain euglycemia compared to placebo. Accordingly, clamp-derived insulin sensitivity index improved after insulin spray. In obese subjects, this insulin sensitizing effect could not be detected.. Change in the high frequency band of heart rate variability, an estimate of parasympathetic output, correlated positively with change in whole-body insulin sensitivity after intranasal insulin. ...
A common cause of clogged ears with inability to pop them easily is due to eustachian tube dysfunction. There are a number of ways to address this annoying problem, but one of the first steps to try is intranasal medications whether in nasal spray form or nasal drop form.
This was a prospective, randomized, double-blind, parallel-group trial to evaluate the effects of nasally applied xenon on intraoperative and postoperative opioid requirement and postoperative evaluated pain scores. Because there were only two treatment arms (air, xenon) with an a priori fixed number of patients (20 per each arm), a simple randomization scheme was used with a vector of random numbers to generate an a priori list for randomized treatment assignments. According to this randomization list, patients received either xenon or air. The study supervisor, who did not participate in the assessment, prepared an unlabeled gas reservoir filled with either the colorless and odorless xenon or air as placebo. The anesthetists who provided the anesthesia and the intensive care unit (ICU) staff participating in the pain assessments were blinded for individual treatments. Patients were also blinded for group assignment and both blindings were maintained until the end of the study. The patients ...
The aim of the present study was to fabricate a thermosensitive gel containing chlorpheniramine maleate (CPM)-loaded nanoparticles following intranasal administration for effective treatment of...
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The main goal of the study is to look at the effects of intranasal oxytocin on the brain in Autism Spectrum Disorder (ASD). Oxytocin is a hormone that exists
Eur Arch Otorhinolaryngol. 2003 Mar;260(3):135-40. Epub 2002 Nov 6. Clinical Trial; Comparative Study; Randomized Controlled Trial
To assess the effectiveness of intranasal corticosteroids in the management of NAR compared with no therapy, placebo or other topical or systemic medications, or two or more of the above therapies in combination, or different intranasal corticosteroids regimens.. ...
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A composition and method for nasal administration of pharmaceuticals utilizes glycyrrhetinic acid as an absorption enhancer. The composition comprises an effective amount of the pharmaceutically active substance, glycyrrhetinic acid, in an amount effective for enhancing permeation of the active substance across the nasal membrane, and a basic salt of an amino acid as an adjuvant. The composition may be administered to the nasal cavity in the form of a spray by using an atomizer, nebulizer, spayer, dropper or other device which ensures contact of the composition with the nasal mucus membrane.
Purpose: Antipsychotics are versatile drugs. Intranasal route could provide efficient delivery for certain therapeutic agents; however, studies on intranasal antipsychotics are limited. Moreover, the systemic and central nervous system (CNS) dispositions of active metabolites after intranasal drug administration are seldom investigated. The current project aims to 1) identify the antipsychotics that are more suitable to be developed into intranasal medications; and 2) characterize the CNS pharmacokinetic (PK) and pharmacodynamic (PD) profiles of the selected antipsychotic delivered by intranasal route, with a special attention to the role of drug metabolism in PK and PD outcomes.. Methods: To select an antipsychotic with greater potential for intranasal delivery, a systematic approach was adopted to screen antipsychotic candidates with in silico evaluations and then in vitro permeability assays. The systemic and CNS PK and PD profiles of the selected antipsychotic would be investigated in ...
About Us - Contact Us Google+ Advertise: 2 million page views AllergyCases.org: Case-based Curriculum of Allergy and Immunology Disclaimer: All opinions expressed here are those of their authors and not of their employer. The information provided here is for educational purposes only and is not intended to provide medical advice. By accessing the web site, the visitors acknowledge that there is no physician-patient relationship between them and the authors. Patient Information ...
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One of the biggest questions on everyones mind throughout the conference was: why dont we have more drugs for neurodegenerative diseases? One obvious answer is that it is hard to get drugs across the blood-brain barrier. Dr. Bruce Morimoto of Allon Therapeutics Inc. in his talk "Peptide Therapeutics and Mechanisms for Intranasal Delivery" suggested that one solution to this problem is to use intranasal delivery, which allows drugs to bypass the blood-brain barrier entirely. Another answer for why there are so few drugs for CNS diseases is that many neurodegenerative diseases are protein-aggregation diseases, and protein-protein interactions are notoriously difficult to target. Dr. Jim Wells, Professor in the Department of Pharmaceutical Chemistry at the University of California, San Francisco, discussed two key limitations to targeting protein-protein interactions in his talk entitled "Challenges of Protein-Protein/Protein-Peptide Targets." First, proteins often associate with one another ...
415 Ala Gln Lys Asp Ser Met Gln Asp Glu Ser Ser Gln Thr Ser Leu Gln 420 425 430 Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 435 440 445 Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 450 455 460 Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys 465 470 475 480 Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 485 490 495 Ser 151403PRTHomo sapiens 15Met Ala Thr Gln Gln Lys Ala Ser Asp Glu Arg Ile Ser Gln Phe Asp 1 5 10 15 His Asn Leu Leu Pro Glu Leu Ser Ala Leu Leu Gly Leu Asp Ala Val 20 25 30 Gln Leu Ala Lys Glu Leu Glu Glu Glu Glu Gln Lys Glu Arg Ala Lys 35 40 45 Met Gln Lys Gly Tyr Asn Ser Gln Met Arg Ser Glu Ala Lys Arg Leu 50 55 60 Lys Thr Phe Val Thr Tyr Glu Pro Tyr Ser Ser Trp Ile Pro Gln Glu 65 70 75 80 Met Ala Ala Ala Gly Phe Tyr Phe Thr Gly Val Lys Ser Gly Ile Gln 85 90 95 Cys Phe Cys Cys Ser Leu Ile Leu Phe Gly Ala Gly Leu Thr Arg Leu 100 105 110 Pro Ile Glu Asp His Lys Arg Phe His Pro Asp Cys Gly Phe Leu Leu 115 120 125 ...
To determine the pharmacokinetics of 4 intranasal doses of naloxone compared to a 0.4 mg dose of naloxone administrated intramuscular and to identify an
Budesonide nasal spray is used to treat an itchy or runny nose, sneezing, or other symptoms caused by hay fever (allergic rhinitis). It is a steroid (cortisone-like medicine) that works by preventing the inflammation that occurs with allergic reactions. ...
Influenza virus infection in pigs is a major farming problem, causing considerable economic loss and posing a zoonotic threat. In addition the pig is an excellent model for understanding immunity to influenza viruses as this is a natural host pathogen system. Experimentally, influenza virus is delivered to pigs intra-nasally, by intra-tracheal instillation or by aerosol, but there is little data comparing the outcome of different methods. We evaluated the shedding pattern, cytokine responses in nasal swabs and immune responses following delivery of low or high dose swine influenza pdmH1N1 virus to the respiratory tract of pigs intra-nasally or by aerosol and compared them to those induced in naturally infected contact pigs. Our data shows that natural infection by contact induces remarkably high innate and adaptive immune response, although the animals were exposed to a very low virus dose. In contacts, the kinetics of virus shedding were slow and prolonged and more similar to the low dose ...
Mild nasopharyngeal irritation following the use of beclomethasone aqueous nasal spray has been reported in up to 24% of patients treated, including occasional sneezing attacks (about 4%) occurring immediately following use of the spray. In patients
Mild nasopharyngeal irritation following the use of beclomethasone aqueous nasal spray has been reported in up to 24% of patients treated, including occasional sneezing attacks (about 4%) occurring immediately following use of the spray. In patients
Our previous studies identified a long-term population of plasma cells in the NALT after influenza virus infection that may have an important role in protection from re-infection 4. However, long-term virus-specific plasma cells do not appear to be induced after RSV infection in the NALT, even though serum antibody was clearly detectable 5, leading us to propose that this NALT population may be important in protection from RSV infection. Our results demonstrate that the mucosal response, as indicated by the levels of IgA in the lung, seems to fall rapidly after RSV infection but is boosted and maintained to higher levels after immunisation with iRSV + DOMV. Furthermore, an increased frequency of RSV-specific plasma cells is apparent within the D-NALT after iRSV + DOMV immunisation. Immunisation with iRSV + OMV also generates complete protection against viral replication after live RSV challenge.. Immunisation with iRSV + DOMV generated few splenic IFN-γ-producing cells, indicating that the MHC ...
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The present invention relates to an improvement in a method of contraception, in treatment of benign gynecological disorders, and in hormone replacement. The improved method includes administering intranasally an estrogenic compound and an androgenic compound, and in some embodiments an optional progestin compound, in a once-daily bolus formulation comprised of the two or three steroids complexed with a cyclodextrin. An intranasal delivery system for administration of the formulation is also described.
Some people only need a nasal spray for the hay fever season (a few months). However, if you have a persistent rhinitis, you may have to take treatment long-term to keep symptoms away. Long-term use of a steroid nasal spray is thought to be safe.. Once symptoms are gone, you are still likely to need to use a steroid nasal spray regularly, to keep symptoms away. Your doctor may advise that you reduce the dose to a lower maintenance dose once symptoms have gone. The aim is to find the lowest dose that controls symptoms.. An occasional forgotten dose should not be a problem, but symptoms usually return after a few days if you stop taking the spray.. ...
A pump (1) has a tubular inlet portion (4) which is arranged to penetrate the mouth (27) of a container having a seal (29) in order to dispense liquid from the container. The pump has a body (2) connected to a housing (23) comprising holding means (25) which holds the container such that in a first position the inlet portion of the pump is external to the seal and in a second position the inlet portion extends through the seal into a reservoir (30) to allow liquid to be dispensed. In the second position, the inlet portion projects into the reservoir to an extent sufficient to displace a volume of liquid filling the inlet channel (6) of the pump and occupying the pump chamber (3). The pump is thereby rendered self priming by the initial movement between the first and second positions which at the same time disrupts the seal. The pump is particularly useful for the nasal administration of liquid sprays from an ampule having an elastomeric seal closure or a duck bill valve.
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Dr. William H. Frey II is Director of the Alzheimers Research Center at Regions Hospital in St. Paul, MN, Professor of Pharmaceutics and faculty member in Neurology, Oral Biology and Neuroscience at the University of Minnesota and consultant to the pharmaceutical and biotechnology industry. His patents, owned by Novartis, Stanford University, HealthPartners Research Foundation and others, target noninvasive delivery of therapeutic agents, including stem cells, to the brain and spinal cord for treating neurological disorders, psychiatric disorders and obesity. Dr. Freys non-invasive intranasal method for bypassing the blood-brain barrier to target CNS therapeutic agents to the brain while reducing systemic exposure and unwanted side effects has captured the interest of both pharmaceutical companies and neuroscientists. The intranasal insulin treatment he developed for Alzheimers disease has been shown in clinical trials to improve memory in both Alzheimers patients and normal adults. With ...
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First of all HGH like all protein hormones needs to be taken by injection (or in some cases nasal administration) to avoid digestion in the stomach. This is why insulin has to be given by...
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Heska offers veterinary products including veterinary lab systems, diagnostic products, heartworm testing, allergy remedies, renal health screening, and intranasal vaccines for the optimal health of small animals.
Average plasma concentration of [3H]-mannitol versus time in femoral vein-cannulated SD rats following the intranasal administration of each peptide formulation
Thank you for the comprehensive review on awake FOI. Regarding the nasal route to FOI and ETT size, you mentioned using a smaller tube size for ease of placement. Are you referring to a normal ETT or a Nasal RAE tube or both? Do you ever find that the smaller size limits your depth and ability to reach the vocal cords? Do you recommend a half size or full size smaller than you would use for a normal intubation? Thank you for the podcasts!. ...
5. Since the medicine will be over-the-counter, you will likely have to purchase it "out of pocket," which is the case with many antihistamines and heartburn medications. This could increase the amount of money you pay each year for health costs.. Unlike taking a pill, the way you use the nasal spray is important. As mentioned above, it is important to avoid spraying the medicine into the middle of the nose, the septum bone that separates the nostrils. Sometimes it helps to use a mirror, or have another person or doctor make sure this is being done correctly. If you do not use the medicine correctly, it may not work, or worse, could cause serious side effects.. As with all medications, the benefits and risks should be weighed before deciding on a treatment plan. When used properly, nasal steroid sprays can be very effective at treating allergies. It is just important to recognize that steroid nose sprays can create risks if not monitored or used correctly.. Your allergist is trained to help you ...
Mean (+ SE) glucagon serum concentration profiles in rats following 28 consecutive days of daily intra-nasal administration-Day 28. Glucagon concentrations on
Nasal spray applicator, high-speed photograph. The spray visible here shows the release of the decongestant. In actual use, the tip of the spray applicator is placed inside the opening of one of the nostrils. - Stock Image C016/9644
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In children with persistent stuffy nose due to allergy, or allergic rhinitis, long-term use of the steroid nasal spray appears to have no effect on growth, researchers say.
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Nasal sprays can be tempting to use as a remedy for winter allergies, but WDSU medical editor Dr. Corey Hebert says repeated use can damage cells.
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Luffeel nasal spray is effective in the treatment of hay fever, the carefully chosen ingredients in Luffeel complement each other in order to address a broad sp
Q. I need help with my nasal spray addiction. Ive been addicted to Dristan for more than 15 years. It costs me $18 every two weeks for three bottles. I keep one with me everywhere I go: to the movies…. ...
Κατηγορία προϊόντων φαρμακείου: ΕΠΟΧΙΚΑ > Χειμωνιάτικη Φροντίδα > Ρινική Καταρροή & Συμφόρηση. Medichrom: Medichrom Bio Nowzen Nasal Spray με Αλόη & Υαλουρονικό οξύ, 20ml. Διαθεσιμότητα: Άμεσα Διαθέσιμο ...
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Adjuvants for administration, particularly for mucosal administration, of an antigen, are described, as well as compositions comprising the described adjuvant in combination with an antigen and a phys
Leave aside what you may think of the notion. Why does any reporter allow a source to remain anonymous on a quote like this, and why does any editor allow the quote to appear without a name attached to it? The stated reason -- "because the issue is still being debated internally" -- is transparent bullshit. Look at the quote. Does any sentient primate believe that it took this White House longer than eight seconds to "debate" this particular line of political attack? "Seemed to hint" at political implications? Is the WaPo now written by four-year-olds or does it presume its written for them? There is only one reason to blind this quote --- to make sure that when the really high quality slime comes out of the White House, youre still on the delivery route. It is a way to volunteer to be part of a political dirty-tricks operation robed in constitutional privileges. This is the kind of stuff that was supposed to stop after Jayson Blair and Judy Miller and, I swear, theres at least a half-dozen ...
Until now, only injectable vaccines against influenza have been available. Parents are reluctant to subject children to the pain of injections, but adults, who are ...
You may not feel the maximum benefit from your medicine straight away, but it is important that you continue to use it daily. It may take a few days until you get maximum relief from your medicine ...
You may not feel the maximum benefit from your medicine straight away, but it is important that you continue to use it daily. It may take a few days until you get maximum relief from your medicine ...
DISCONTINUED BY MANUFACTURER. FOR YOUR INFORMATION PURPOSES, WE HAVE KEPT THIS ITEM PLACEMENT AS COURTESY TO OUR CUSTOMERSYou may search for a related or...
SurfControl announced End-User Spam Management and Report Central tools, its enhancements to SurfControl E-mail Filter. Spam Management sends daily e-mail to inform users that the system has isolated suspect spam e-mail messages that require their review. Report Central key features: web-based interface to provide a view into all SurfControl E-mail Filter reports, scheduling and auto-distribution […]. SurfControl announced End-User Spam Management and Report Central tools, its enhancements to SurfControl E-mail Filter. Spam Management sends daily e-mail to inform users that the system has isolated suspect spam e-mail messages that require their review. Report Central key features: web-based interface to provide a view into all SurfControl E-mail Filter reports, scheduling and auto-distribution features, and authenticated access control to reports, among others. Spam Management will be available May, 2004 and Report Central June, 2004. More. ...
According to Food Safety News, the Pennsylvania Department of Health has added another six cases to the ongoing Campylobacter outbreak linked to raw milk f
We investigated whether the use of an intranasal corticosteroid can modify BHR during the grass pollen season in patients with mild asthma and seasonal allergic rhinitis. The effect of FP on BHR was studied in one season and the effect of equipotent doses of FP and BDP was studied in the next season. In the first season we found a significant and equal increase in BHR in patients in both the FP and placebo groups. In the next season we observed no increase in BHR in patients given placebo nor in those treated with BDP or FP. As expected, we found a decrease in nasal symptoms with intranasal corticosteroids. Rather unexpectedly, we found an improvement in % predicted FEV1 under low allergen exposure in the patients treated with BDP or FP. Thus, intranasal steroids were not able to prevent the increase in BHR which occurred in the first season nor to reduce BHR in the second season.. The increase in BHR during the grass pollen season is thought to be caused by a gradual cumulative effect of ...
To our knowledge, this is the youngest patient reported with ICS due to intranasal use of a prescribed dose of an ophthalmic steroid. Our patient was diagnosed after only a 6-week course of dexamethasone ocular drops compared with a previously prescribed 3-month course.6 Given that intranasal steroids are commonly prescribed to infants and children for a variety of diagnoses, this case highlights the risks inherent in the use, even short-term, of intranasal steroid drops, particularly in young infants, for both adrenal suppression and linear growth deceleration. Because oral and topical glucocorticoids are a more common cause of ICS, there are limited reports of intranasal steroids as the etiology,5-9 with patients being diagnosed with ICS anywhere from 2 to 4 months to several years after steroid initiation.. Infants given intranasal dexamethasone drops may be at higher risk for systemic absorption through the gastrointestinal tract because they are often supine during administration and may ...
Rift Valley fever virus (RVFV) causes severe disease in humans and ungulates. The virus can be transmitted by mosquitoes, direct contact with infected tissues or fluids, or aerosol, making it a significant biological threat for which there is no approved vaccine or therapeutic. Herein we describe the evaluation of DEF201, an adenovirus-vectored interferon alpha which addresses the limitations of recombinant interferon alpha protein (cost, short half-life), as a pre- and post-exposure treatment in a lethal hamster RVFV challenge model. DEF201 was delivered intranasally to stimulate mucosal immunity and effectively bypass any pre-existing immunity to the vector. Complete protection against RVFV infection was observed from a single dose of DEF201 administered one or seven days prior to challenge while all control animals succumbed within three days of infection. Efficacy of treatment administered two weeks prior to challenge was limited. Post‑exposure, DEF201 was able to confer significant protection
Development of vaccines in autoimmune diseases has received wide attention over the last decade. However, many vaccines showed limited clinical efficacy. To enhance vaccine efficacy in infectious diseases, biocompatible and biodegradable polymeric nanoparticles have gained interest as antigen delivery systems. We investigated in mice whether antigen-encapsulated PLGA (poly-lactic-co-glycolic acid), PLGA-TMC (N-trimethyl chitosan) or TMC-TPP (tri-polyphosphate) nanoparticles can also be used to modulate the immunological outcome after nasal vaccination. These three nanoparticles enhanced the antigen presentation by dendritic cells, as shown by increased in vitro and in vivo CD4(+) T-cell proliferation. However, only nasal PLGA nanoparticles were found to induce an immunoregulatory response as shown by enhanced Foxp3 expression in the nasopharynx associated lymphoid tissue and cervical lymph nodes. Nasal administration of OVA-containing PLGA particle resulted in functional suppression of an ...
Oxytocin, a hormone that promotes emotional bonding, also benefits people having trouble dealing with stress. A new study suggests that giving oxytocin for a week shortly following a traumatic experience reduces the risk that the recipient will develop post-traumatic stress disorder (PTSD).. In the study by researcher Mirjam van Zuiden and colleagues, people who visited an emergency room following some kind of trauma were randomized to receive either a placebo nasal spray or intranasal oxytocin twice daily for 7.5 days beginning within 12 days after the trauma. The dosage was 40 IU twice daily.. For those participants with severe PTSD symptoms at baseline, repeated oxytocin administration prevented worsening PTSD. The research was presented at the 2016 meeting of the Society of Biological Psychiatry.. ...
The effect of intranasal spray of norethisterone (NET) [68-22-4] and progesterone (P) [57-83-0] on serum testosterone (T) [58-22-0] and total sperm count in adult male bonnet monkeys and the effect of NET spray on the menstrual cycle in female monkeys was studied. Whereas NET spray resulted in a drastic decrease in serum T levels and sperm count, P spray caused a decrease in total sperm count only. Intranasal spray of NET in adult cycling female monkeys between days 5 and 14 shortened the menstrual cycle ascribed to a decrease in serum FSH [9002-68-0], LH [9002-67-9], 17$\beta$-estradiol [50-28-2], and P levels. Nasal spray of only solvent in male or female monkeys had no effect on any of the parameters tested. ...
The need for an efficacious vaccine against the potential bioterrorism agent Francisella tularensis is a consequence of its low infectious dose, high mortality rate, and ability to be spread via aerosol, leading to pneumonic disease. FTN0109 is a novel protein that may be associated with the outer membrane of the bacterium and which is expressed across all subspecies of Francisella. In this study, we sought to determine the efficacy of ΔFTN0109 as a putative vaccine candidate. Using intramacrophage replication assays, ΔFTN0109 has been shown to be highly attenuated for growth. Moreover, the LD50 for this defined vaccine strain is ,105 CFU in BALB/c and C57BL/6 mice following intranasal challenge in comparison to its parental strain U112 (LD50,10 CFU). Intranasal vaccination with ΔFTN0109 induces the expression of splenic antigen-specific IFN-γ and IL-2, with concurrent induction of preferential Th1 humoral responses (increased serum IgG2a over IgG1). Intranasal immunization with ΔFTN0109 ...
The immune system has evolved to use sophisticated mechanisms to recruit lymphocytes to sites of pathogen exposure. Trafficking pathways are precise. For example, lymphocytes that are primed by gut pathogens can, in some cases, be imprinted with CCR9 membrane receptors, which can influence migration to the small intestine. Currently, little is known about T cell trafficking to the upper respiratory tract or the relationship between effectors that migrate to the diffuse nasal-associated lymphoid tissue (d-NALT), the lower airways, and the lung. To determine whether a T cell primed by Ag from a respiratory pathogen is imprinted for exclusive trafficking to the upper or lower respiratory tract or whether descendents from that cell have the capacity to migrate to both sites, we inoculated mice by the intranasal route with Sendai virus and conducted single-cell-sequencing analyses of CD8+ T lymphocytes responsive to a Kb-restricted immunodominant peptide, FAPGNYPAL (Tet+). Cells from the d-NALT, lung ...
Efficacy of intranasal administration of artesunate in experimental cerebral malaria. . Download books free in pdf. Online library with books, university works and thousands of documents available to read online and download.
Placebo-controlled randomised controlled trials (RCTs) that assessed the ocular efficacy of intranasal corticosteroids in patients with seasonal allergic rhinitis were eligible for inclusion in the review. Ocular efficacy could be assessed as a primary or secondary outcome or as part of a non-nasal symptom score (which included three ocular symptoms such as eye-itching, eye tearing, eye redness and ear/palate itching). Eligible intranasal corticosteroids were beclomethasone dipropionate, budesonide, ciclesonide, flunisolide, fluticasone furoate, fluticasone propionate, mometasone furoate and triamcinolone acetonide.. Ten of the included studies compared intranasal corticosteroids to placebo and also included an active comparator arm (another intranasal corticosteroids or antihistamine). Included patients included both males and females with mild to severe seasonal allergic rhinitis at baseline. Seasonal allergic rhinitis was due to various allergens (such as birch, ragweed, grass and mountain ...
Lancet Infectious Diseases Jan 2018 Volume 18 Number 1 p1-122 e1-e32 http://www.thelancet.com/journals/laninf/issue/current Personal View Urgent challenges in implementing live attenuated influenza vaccine Anika Singanayagam, Maria Zambon, Ajit Lalvani, Wendy Barclay Summary Conflicting reports have emerged about the effectiveness of the live attenuated influenza vaccine. The live attenuated influenza vaccine appears to protect particularly poorly against…
Bovine respiratory syncytial virus (BRSV) is the principal aetiological agent of the bovine respiratory disease complex. A BRSV subunit vaccine candidate consisting of two synthetic peptides representing putative protective epitopes on BRSV surface glycoproteins in soluble form or encapsulated in poly(lactide-co-glycolide) (PLG) microparticles were prepared. Calves (10 weeks old) with diminishing levels of BRSV-specific maternal antibody were intranasally administered a single dose of the different peptide formulations. Peptide-specific local immune responses (nasal secretion IgA), but not systemic humoral (serum IgG) or cellular responses (serum IFN-γ), were generated by all forms of peptide. There was a significant reduction in occurrence of respiratory disease in the animals inoculated with all peptide formulations compared to animals given PBS alone. Furthermore no adverse effects were observed in any of the animals post vaccination. These results suggest that intranasal immunisation with ...
The report provides a basic overview of the China Inhalation & Nasal Spray Generic Drugs industry including definitions, segmentation, applications, key vendors, market drivers and market challenges. The China Inhalation & Nasal Spray Generic Drugs Market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status. Through the statistical analysis, the report depicts the global China Inhalation & Nasal Spray Generic Drugs Market including capacity, production, production value, cost/profit, supply/demand and import/export. The total market is further divided by company, by country, and by application/type for the competitive landscape analysis.. Table of Contents. Chapter One China Inhalation & Nasal Spray Generic Drugs Industry Overview. • China Inhalation & Nasal Spray Generic Drugs Definition (Product Picture and Specifications). • China Inhalation & Nasal Spray Generic Drugs Classification and ...
Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be beneficial in chronic rhinosinusitis (CRS). Previous studies have examined effects of topical/nasal LAB in children with secretory otitis media, but little is as yet known about their effects on the human nasal airway. The aim of this pilot study was to examine effects on nasal symptoms and commensal bacteria in healthy subjects of nasal administration of a honeybee LAB microbiome; ie, a mixture of 9 Lactobacillus spp. and 4 Bifidobacterium spp. obtained from the honeybee Apis mellifera. Furthermore, we aimed to assess whether or not the honeybee LAB produced a local inflammatory response ...
Escherichia coli heat-labile enterotoxin, molecular model. This is one of several proteins produced by pathogenic E. coli bacteria in the intestines. Unlike the heat-stable enterotoxin, this one is inactivated at high temperatures. The toxin causes diarrhoea and can be fatal in severe cases. This protein consists of three subunits with a total of seven chains and a total of 329 amino acids. - Stock Image C025/1673
Two commercial live virus infectious bovine rhinotracheitis (IBR) vaccines for intranasal administration and an inactivated polyvalent calf pneumonia vaccine were compared for safety and efficacy in calves against experimental IBR infections. All three products were clinically safe for use in young calves; a mild, transient, febrile response was induced by one of the live vaccines. Vaccinal virus was recovered for up to 16 days after vaccination from nasal secretions of all calves given live vaccine. Both live vaccines stimulated a serum neutralising antibody response, but the inactivated vaccine failed to elicit any serological response. Following intranasal challenge four months after the first dose of vaccine, all live virus vaccinates remained systemically healthy. A slight nasal discharge and a few rapidly healing ulcers of the nasal mucosa were the only abnormalities observed. Both the group given the inactivated vaccine and the unvaccinated controls developed clinical IBR with pyrexia, ...
Patent and Trademark Office Notices  Patent and Trademark Office Notices
16, 2011 Wayne Jeffrey Perry Therapeutic Agent For Intranasal Administration And Method Of Making And Using Same 13/235,018 Sep ... 16, 2011 Wayne Jeffrey Perry Therapeutic Agent For Intranasal Administration And Method Of Making And Using Same 13/270,861 Oct ... Any inquiries concerning this notice may be directed to Bryan Lin, Office of PCT Legal Administration, at 571-272-3303, or via ... It is preferred that such initial requests be hand-carried to: Office of Patent Legal Administration Room MDW 7D55 600 Dulany ...
more infohttps://www.uspto.gov/web/offices/com/sol/og/2013/week08/TOC.htm
Intranasal Administration of Hsp70: Molecular and Therapeutic Consequences | SpringerLink  Intranasal Administration of Hsp70: Molecular and Therapeutic Consequences | SpringerLink
2014). Intranasal administration as a route for drug delivery to the brain: Evidence for a unique pathway for albumin. The ... Evgenev M.B., Garbuz D.G., Morozov A.V., Bobkova N.V. (2018) Intranasal Administration of Hsp70: Molecular and Therapeutic ... Taken together, our findings establish intranasal administration of exogenous human Hsp70 as a practical therapeutic approach ... 2008). Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-319-89551-2_16
Patent US5112804 - Pharmaceutical composition and method of intranasal administration - Google Patents  Patent US5112804 - Pharmaceutical composition and method of intranasal administration - Google Patents
A composition and method for nasal administration of pharmaceuticals utilizes glycyrrhetinic acid as an absorption enhancer. ... The intranasal administration of vitamin B-12 is illustrated as follows.. 1 ml of a vitamin B-12 solution containing 1,000μg/ml ... The intranasal administration of human ACTH is illustrated as follows.. A 0.5% (w/v) 18β-glycyrrhetinic acid vehicle solution ... Pharmaceutical preparations for intranasal administration. US5989582 *. 14 Feb 1996. 23 Nov 1999. Weg; Stuart L.. ...
more infohttp://www.google.com.au/patents/US5112804
Cell-Penetrating Peptide-Modified Block Copolymer Micelles Promote Direct Brain Delivery via Intranasal Administration |...  Cell-Penetrating Peptide-Modified Block Copolymer Micelles Promote Direct Brain Delivery via Intranasal Administration |...
We evaluated the brain distribution of coumarin, acting as a model chemical, after intravenous or intranasal administration of ... The amount of coumarin in the brain after intranasal administration was significantly higher than that after intravenous ... Finally, we determined the brain distribution and biodistribution after intranasal administration of coumarin-loaded MPEG-PCL- ... Cell-Penetrating Peptide-Modified Block Copolymer Micelles Promote Direct Brain Delivery via Intranasal Administration. ...
more infohttps://link.springer.com/article/10.1007%2Fs11095-011-0440-7
Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice  Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice
... ... We aimed at testing the immunomodulatory effects of intranasal versus intragastric administration of Lactobacillus paracasei ... A concerted selection of intervention schedule, doses, and administration routes (intranasal versus intragastric) may markedly ... Intranasal L. paracasei NCC2461 efficiently protected sensitized mice upon exposure to OVA aerosols in a dose-dependent manner ...
more infohttps://www.hindawi.com/journals/iji/2012/686739/abs/
Study of the Tolerability of Ketorolac Tromethamine Following Intranasal Administration in Healthy Volunteers - Full Text View ...  Study of the Tolerability of Ketorolac Tromethamine Following Intranasal Administration in Healthy Volunteers - Full Text View ...
Study of the Tolerability of Ketorolac Tromethamine Following Intranasal Administration in Healthy Volunteers. The safety and ... Study of the Tolerability of Formulations of Ketorolac Tromethamine Following Intranasal Administration in Healthy Volunteers. ... Following administration of each treatment, subjects completed a visual analogue scale (VAS) (ranging from no discomfort to ... In Part B subjects were randomized to receive a single intranasal dose of 15 mg ketorolac tromethamine containing 0% lidocaine ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01363063?intr=ketorolac&
Molecules | Free Full-Text | Identification of Absorbed Constituents in the Rabbit Plasma and Cerebrospinal Fluid after...  Molecules | Free Full-Text | Identification of Absorbed Constituents in the Rabbit Plasma and Cerebrospinal Fluid after...
... after intranasal administration of Asari Radix et Rhizoma (AR). In total, 47 absorbed AR constituents including 14 monoterpenes ... and comprehensively analyze the absorbed constituents after intranasal administration of TCM. These findings extend our ... Keywords: nasal therapy; Asarum heterotropoides var. mandshuricum; intranasal administration; effective substance; ... Identification of Absorbed Constituents in the Rabbit Plasma and Cerebrospinal Fluid after Intranasal Administration of Asari ...
more infohttps://www.mdpi.com/1420-3049/19/4/4857
Efficacy and Safety Study of Intranasal Administration of 100, 200, and 400 μg of Fluticasone Propionate - Full Text View -...  Efficacy and Safety Study of Intranasal Administration of 100, 200, and 400 μg of Fluticasone Propionate - Full Text View -...
Must be able to cease treatment with intranasal medications including, but not limited to, intranasal steroids, intranasal ... Efficacy and Safety Study of Intranasal Administration of 100, 200, and 400 μg of Fluticasone Propionate. The safety and ... The primary objective of this study is to compare the efficacy of intranasal administration of 100, 200, and 400 μg of ... Multicenter Study Evaluating the Efficacy and Safety of Intranasal Administration of 100, 200, and 400 μg of Fluticasone ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01624662?term=optinose&rank=4
Frontiers | Intranasal Administration of Insulin Reduces Chronic Behavioral Abnormality and Neuronal Apoptosis Induced by...  Frontiers | Intranasal Administration of Insulin Reduces Chronic Behavioral Abnormality and Neuronal Apoptosis Induced by...
These findings suggest that intranasal insulin administration could be an effective approach to prevent the increased risk of ... These findings suggest that intranasal insulin administration could be an effective approach to prevent the increased risk of ... Importantly, insulin administered through intranasal delivery prior to anesthesia was found to prevent the anesthesia-induced ... Importantly, insulin administered through intranasal delivery prior to anesthesia was found to prevent the anesthesia-induced ...
more infohttps://www.frontiersin.org/articles/10.3389/fnins.2019.00706/full
NZ222907A - Preparation for intranasal administration containing a phospholipid absorption enhancing system 
      - Google...  NZ222907A - Preparation for intranasal administration containing a phospholipid absorption enhancing system - Google...
intranasal administration. absorption enhancing. administration containing. enhancing system. Prior art date. 1986-12-16. ... Device for intranasal administration UY32514A (en) 2009-03-27. 2010-10-29. Glaxo Group Ltd. MERGERS & Conjugates of a drug ... Insulin preparation for intranasal administration NL193099C (en) * 1981-10-30. 1998-11-03. Novo Industri As. Stabilized insulin ... Therapeutic compositions for intranasal administration comprising ketorolac. DK36492D0 (en) * 1992-03-19. 1992-03-19. Novo ...
more infohttps://patents.google.com/patent/NZ222907A/en
Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water...  Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water...
Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water ... Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water ... Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water ... Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water ...
more infohttp://jpet.aspetjournals.org/content/293/3/1091/tab-e-letters
GMS | 65th Annual Meeting of the German Society of Neurosurgery (DGNC) | Intranasal administration of neural stem cell-mediated...  GMS | 65th Annual Meeting of the German Society of Neurosurgery (DGNC) | Intranasal administration of neural stem cell-mediated...
Intranasal administration of neural stem cell-mediated enzym/prodrug therapy using a novel HSV-thymidine kinase variant ... Those receiving additional intranasal administration of NSC-TK007 displayed a significant tumor growth inhibition of 81% versus ... Here, we demonstrate that the non-invasive intranasal administration of tumor-targeting NSC is able to deliver a novel suicide ... Therapeutic effects of intratumoral (3x105 cells) and intranasal (1.5x106) NSC-TK007 application alone and the sequential ...
more infohttp://www.egms.de/static/en/meetings/dgnc2014/14dgnc280.shtml
RePub, Erasmus University Repository:
  Intranasal administration of oxytocin decreases task-related aggressive responses in...  RePub, Erasmus University Repository: Intranasal administration of oxytocin decreases task-related aggressive responses in...
Intranasal administration of oxytocin decreases task-related aggressive responses in healthy young males. Publication. ... Intranasal administration of oxytocin decreases task-related aggressive responses in healthy young males. ... In this randomized double-blind, placebo-controlled study, the effects of intranasal oxytocin (32IU) on taskrelated aggressive ... Our results indicate that oxytocin administration reduces aggressive behavior in healthy young men. Moreover, increased ...
more infohttps://repub.eur.nl/pub/118781
Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection by Schistosoma mansoni |...  Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection by Schistosoma mansoni |...
Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection by Schistosoma mansoni T ... Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection by Schistosoma mansoni ... Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection by Schistosoma mansoni ... Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection by Schistosoma mansoni ...
more infohttps://iai.asm.org/content/67/9/4360?ijkey=7d9c9c103d436f81383792787ca40b4f13d27e72&keytype2=tf_ipsecsha
Intranasal Administration of an Inactivated Yersinia pestis Vaccine with Interleukin-12 Generates Protective Immunity against...  Intranasal Administration of an Inactivated Yersinia pestis Vaccine with Interleukin-12 Generates Protective Immunity against...
Intranasal Administration of an Inactivated Yersinia pestis Vaccine with Interleukin-12 Generates Protective Immunity against ... Intranasal Administration of an Inactivated Yersinia pestis Vaccine with Interleukin-12 Generates Protective Immunity against ... Intranasal Administration of an Inactivated Yersinia pestis Vaccine with Interleukin-12 Generates Protective Immunity against ... Intranasal Administration of an Inactivated Yersinia pestis Vaccine with Interleukin-12 Generates Protective Immunity against ...
more infohttps://cvi.asm.org/content/18/11/1925
Administration, Intranasal | Profiles RNS  Administration, Intranasal | Profiles RNS
Intranasal" by people in this website by year, and whether "Administration, Intranasal" was a major or minor topic of these ... "Administration, Intranasal" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Administration, Intranasal" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Administration, Intranasal". ...
more infohttps://profiles.rush.edu/display/21970
Administration, Intranasal | The Chopra Library  Administration, Intranasal | The Chopra Library
Could intranasal oxytocin be used to enhance relationships? Research imperatives, clinical policy, and ethical considerations. ... This is the first experimental study on the effect of oxytocin administration on the neural processing of facial stimuli ... The impact of oxytocin administration and maternal love withdrawal on event-related potential (ERP) responses to emotional ... we studied the effects of 16 IU of intranasal oxytocin on ERPs to pictures combining performance feedback with emotional facial ...
more infohttp://isharonline.org/tags/administration-intranasal
Molecular Mechanisms of Induction of Antigen-Specific Allograft Tolerance by Intranasal Peptide Administration | The Journal of...  Molecular Mechanisms of Induction of Antigen-Specific Allograft Tolerance by Intranasal Peptide Administration | The Journal of...
We have previously shown that intranasal (i.n.) administration of a single MHC class II-restricted HY peptide to female mice ... Molecular Mechanisms of Induction of Antigen-Specific Allograft Tolerance by Intranasal Peptide Administration. Katy Derbyshire ... Molecular Mechanisms of Induction of Antigen-Specific Allograft Tolerance by Intranasal Peptide Administration ... Molecular Mechanisms of Induction of Antigen-Specific Allograft Tolerance by Intranasal Peptide Administration ...
more infohttp://www.jimmunol.org/content/early/2011/04/12/jimmunol.1002444
Intranasal administration of acetylcholinesterase inhibitors | BMC Neuroscience | Full Text  Intranasal administration of acetylcholinesterase inhibitors | BMC Neuroscience | Full Text
Intranasal drug delivery is an effective option for the treatment of Alzheimers disease and other central nervous system ... and opportunities for intranasal acetylcholinesterases, in particular galantamine. An in vitro screening model facilitated the ... Liu XF, Fawcett JR, Throne RG, DeFor TA, Frey WH: Intranasal administration of insulin-like growth factor-I bypasses the blood- ... Wang D, Gao Y, Yun L: Study on brain targeting of raltitrexed following intranasal administration in rats. Cancer Chemother ...
more infohttps://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-9-S3-S6
Intranasal administration of acetylcholinesterase inhibitors | BMC Neuroscience | Full Text  Intranasal administration of acetylcholinesterase inhibitors | BMC Neuroscience | Full Text
Intranasal drug delivery is an effective option for the treatment of Alzheimers disease and other central nervous system ... and opportunities for intranasal acetylcholinesterases, in particular galantamine. An in vitro screening model facilitated the ... Liu XF, Fawcett JR, Throne RG, DeFor TA, Frey WH: Intranasal administration of insulin-like growth factor-I bypasses the blood- ... Wang D, Gao Y, Yun L: Study on brain targeting of raltitrexed following intranasal administration in rats. Cancer Chemother ...
more infohttps://0-bmcneurosci-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2202-9-S3-S6
  • Intranasal L. paracasei NCC2461 efficiently protected sensitized mice upon exposure to OVA aerosols in a dose-dependent manner as compared to control mice. (hindawi.com)
  • Therapeutic effects of intratumoral (3x10 5 cells) and intranasal (1.5x10 6 ) NSC-TK007 application alone and the sequential combination of both was tested using an intracranial U87 human glioblastoma model in nude mice. (egms.de)
  • Recently, intranasal (i.n.) immunization of mice with a recombinant BCG strain expressing GST was reported to induce humoral responses as well as antibodies which neutralized the enzyme activity ( 12 ). (asm.org)
  • We have previously shown that intranasal (i.n.) administration of a single MHC class II-restricted HY peptide to female mice induces tolerance to up to five additional epitopes expressed on test male grafts, a phenomenon known as linked suppression. (jimmunol.org)
  • To determine how the route of immunization affects CD8+ T cell responses in the lungs of mice vaccinated with a murine cytomegalovirus vector expressing the respiratory syncytial virus matrix (M) protein, we infected CB6F1 mice via the intranasal or intraperitoneal route and evaluated the M-specific CD8+ T cell response at early and late time points. (edu.au)
  • Here, we show that, although intranasal vaccination with cationic liposomes in combination with antigenic protein elicited GM-CSF expression at the site of administration, blocking GM-CSF function by using an anti-GM-CSF neutralizing antibody did not alter antigen-specific antibody production induced by DOTAP/DC-chol liposomes, indicating that GM-CSF may not contribute to the mucosal adjuvant activity of the cationic liposomes when administered intranasally. (biomedcentral.com)
  • We found that intranasal vaccination generated robust and durable tissue-resident effector and effector memory CD8+ T cell populations that were undetectable after intraperitoneal vaccination. (edu.au)
  • The generation of these antigen-experienced cells by intranasal vaccination resulted in earlier T cell responses, interferon gamma secretion, and viral clearance after respiratory syncytial virus challenge. (edu.au)
  • Intranasal supplementation of L. paracasei NCC2461 was more potent than intragastric application in limiting the allergic response and possibly linked to an increase in T regulatory cells in the lungs. (hindawi.com)
  • Since during the invasion of the parasite into the host the schistosomula migrate first to the lungs, the intranasal route of administration was employed in order to halt the parasite at an early stage of the infection. (asm.org)
  • Salivary oxytocin, cortisol and testosterone were measured serially prior to the intervention, and then before and after the PSAP, to evaluate the effects of oxytocin administration on hormonal functioning in relation to aggression. (eur.nl)
  • Our results indicate that oxytocin administration reduces aggressive behavior in healthy young men. (eur.nl)
  • We concluded that intranasal imiquimod facilitates a more effective immune response, which can limit the pathology associated with influenza A virus infection. (flu.org.cn)
  • In Part B subjects were randomized to receive a single intranasal dose of 15 mg ketorolac tromethamine containing 0% lidocaine hydrochloride into one nostril and either placebo or a single intranasal dose of 15 mg ketorolac tromethamine containing 0%, 4% or 6% lidocaine hydrochloride into the other nostril. (clinicaltrials.gov)
  • The objective of this study was to compare the tolerability of formulations of ketorolac tromethamine with differing concentrations of lidocaine hydrochloride (0% and 6% in Part A and 0%, 4%, 6% and placebo in Part B) following intranasal administration to healthy volunteers. (clinicaltrials.gov)
  • In addition, oxytocin was measured in urine collected directly after the experimental task, reflecting the 2 h period after oxytocin or placebo administration. (eur.nl)
  • Using a double-blind, placebo-controlled within-subjects design, we studied the effects of 16 IU of intranasal oxytocin on ERPs to pictures combining performance feedback with emotional facial expressions in 48 female undergraduate students. (isharonline.org)
  • In this article, headspace-solid phase microextraction-gas chromatography-mass spectrometry and high performance liquid chromatography-atmospheric pressure chemical ionization-ion trap-time of flight-multistage mass spectrometry were applied for the first time to analyze the absorbed constituents in rabbit plasma and cerebrospinal fluid (CSF) after intranasal administration of Asari Radix et Rhizoma (AR). (mdpi.com)
  • Following administration of each treatment, subjects completed a visual analogue scale (VAS) (ranging from 'no discomfort' to 'severe discomfort') at 1, 5, 10 and 15 minutes post-dose. (clinicaltrials.gov)
  • To avoid pain and anxiety caused by IM injections in children, intranasal route have been evaluated for the induction of sedation or analgesia. (ivsajournals.com)
  • However, activation of innate immunity might be much more important for their adjuvant activities, including recruitment of innate immune cells at the site of administration and induction of cytokines and chemokines [ 10 , 11 , 12 ]. (biomedcentral.com)
  • Pre-administration of GH blunts the GH-releasing effect of examorelin, while, in contrast, fully abolishing the effect of GHRH. (wikipedia.org)
  • Anesthetized rats were administered FLT or FDG by intranasal instillation (IN) or tail-vein injection (IV). (springer.com)
  • OBJECTIVE: To apply the Bradford Hill criteria, which are widely used to establish causality between an environmental agent and disease, to evaluate the relationship between over-the-counter intranasal zinc gluconate therapy and anosmia. (isharonline.org)
  • Finally, intranasal L. plantarum NCC1107 reduced total and eosinophilic lung inflammation, but increased neutrophilia and macrophages infiltration. (hindawi.com)
  • This graph shows the total number of publications written about "Administration, Intranasal" by people in this website by year, and whether "Administration, Intranasal" was a major or minor topic of these publications. (rush.edu)
  • This short review outlines the rationale, challenges, and opportunities for intranasal acetylcholinesterases, in particular galantamine. (biomedcentral.com)
  • Finally, we determined the brain distribution and biodistribution after intranasal administration of coumarin-loaded MPEG-PCL-Tat. (springer.com)
  • For FDG, the concentration was substantially higher in the OB than the brain only after IN administration. (springer.com)
  • For FLT, the concentration was higher in the OB than the brain after both IN and IV and higher after IN than after IV administration at all times, whereas the concentration in the brain was higher after IN than after IV administration at early times only. (springer.com)
  • Then, the coumarin distribution after MPEG-PCL-Tat administration in non-targeted tissues (lung, liver, heart, kidney and spleen) was lower than that after coumarin administration without nanomicelles. (springer.com)