Glycyrrhetinic Acid: An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.Administration, Intranasal: Delivery of medications through the nasal mucosa.Glycyrrhizic Acid: A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.Glycyrrhiza: A genus of leguminous herbs or shrubs whose roots yield GLYCYRRHETINIC ACID and its derivative, CARBENOXOLONE.Nasal Mucosa: The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.Glycyrrhiza uralensis: A plant species of the family FABACEAE.11-beta-Hydroxysteroid Dehydrogenases: Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can utilize either NAD or NADP as cofactors.Nasal Sprays: Pharmacologic agents delivered into the nostrils in the form of a mist or spray.Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.Research Subjects: Persons who are enrolled in research studies or who are otherwise the subjects of research.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Anti-Anxiety Agents: Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.H-Y Antigen: A sex-specific cell surface antigen produced by the sex-determining gene of the Y chromosome in mammals. It causes syngeneic grafts from males to females to be rejected and interacts with somatic elements of the embryologic undifferentiated gonad to produce testicular organogenesis.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Skin Transplantation: The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.gp100 Melanoma Antigen: A melanosome-associated protein that plays a role in the maturation of the MELANOSOME.Immune Tolerance: The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.Dendritic Cells: Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.Narcotic Antagonists: Agents inhibiting the effect of narcotics on the central nervous system.Morphine: The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.gamma-Cyclodextrins: Cyclic GLUCANS consisting of eight (8) glucopyranose units linked by 1,4-glycosidic bonds.Analgesics, Opioid: Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.Injections, Intravenous: Injections made into a vein for therapeutic or experimental purposes.Thymidine Kinase: An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.Simplexvirus: A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.Ganciclovir: An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.Congresses as Topic: Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.Societies, Medical: Societies whose membership is limited to physicians.Mice, Inbred NOD: A strain of non-obese diabetic mice developed in Japan that has been widely studied as a model for T-cell-dependent autoimmune insulin-dependent diabetes mellitus in which insulitis is a major histopathologic feature, and in which genetic susceptibility is strongly MHC-linked.Injections, Subcutaneous: Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.Epitopes: Sites on an antigen that interact with specific antibodies.Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.Diabetes Mellitus, Experimental: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.Islets of Langerhans: Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.Glucagon: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Blood Glucose: Glucose in blood.Receptors, Glucagon: Cell surface receptors that bind glucagon with high affinity and trigger intracellular changes which influence the behavior of cells. Activation of glucagon receptors causes a variety of effects; the best understood is the initiation of a complex enzymatic cascade in the liver which ultimately increases the availability of glucose to body organs.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Betula: A plant genus of the family BETULACEAE. The tree has smooth, resinous, varicolored or white bark, marked by horizontal pores (lenticels), which usually peels horizontally in thin sheets.Immunoglobulin E: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Pollen: The fertilizing element of plants that contains the male GAMETOPHYTES.Allergens: Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Antigens, Plant: Substances found in PLANTS that have antigenic activity.Antibodies, Anti-Idiotypic: Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.Remoxipride: An antipsychotic agent that is specific for dopamine D2 receptors. It has been shown to be effective in the treatment of schizophrenia.Antigens, CD95: A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Neuroprotective Agents: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Complement fixation titers in cattle following intranasal inoculation of Hemophilus somnus. (1/2093)
Five bulls were inoculated intranasally with a live culture of Hemophilus somnus originally isolated from a clinical case of Hemophilus septicemia. Preinoculation and postinoculation blood samples were taken at weekly intervals for nine weeks for measuring complement fixation titers and daily postinoculation temperatures were taken for one week. Three animals had transient fever and slight lethargy was observed in two animals had a transitory rise in complement fixation titers in the second to fifth weeks postexposure while one animal which had been seronegative on preinoculation testing produced little serological response to the organism. The experiment demonstrated that the nasal instillation of young cattle using an originally pathogenic H. somnus isolate is capable of stimulating only transitory complement fixation antibody titer. (+info)Zonula occludens toxin is a powerful mucosal adjuvant for intranasally delivered antigens. (2/2093)
Zonula occludens toxin (Zot) is produced by toxigenic strains of Vibrio cholerae and has the ability to reversibly alter intestinal epithelial tight junctions, allowing the passage of macromolecules through the mucosal barrier. In the present study, we investigated whether Zot could be exploited to deliver soluble antigens through the nasal mucosa for the induction of antigen-specific systemic and mucosal immune responses. Intranasal immunization of mice with ovalbumin (Ova) and recombinant Zot, either fused to the maltose-binding protein (MBP-Zot) or with a hexahistidine tag (His-Zot), induced anti-Ova serum immunoglobulin G (IgG) titers that were approximately 40-fold higher than those induced by immunization with antigen alone. Interestingly, Zot also stimulated high anti-Ova IgA titers in serum, as well as in vaginal and intestinal secretions. A comparison with Escherichia coli heat-labile enterotoxin (LT) revealed that the adjuvant activity of Zot was only sevenfold lower than that of LT. Moreover, Zot and LT induced similar patterns of Ova-specific IgG subclasses. The subtypes IgG1, IgG2a, and IgG2b were all stimulated, with a predominance of IgG1 and IgG2b. In conclusion, our results highlight Zot as a novel potent mucosal adjuvant of microbial origin. (+info)The posterior nasal nerve plays an important role on cardiopulmonary reflexes to nasal application of capsaicin, distilled water and l-menthol in anesthetized dogs. (3/2093)
The sensory innervation of the cardiopulmonary reflexes to nasal application of capsaicin (CAPS), distilled water (DW) and l-menthol (LM) was studied in anesthetized dogs breathing through tracheostomy. A marked cardiopulmonary reflex was observed by CAPS and DW into the nasal cavity, while a prolongation of expiration was induced by LM. All these reflexes were significantly decreased by bilateral section of the posterior nasal nerve (PNN) and completely abolished by topical nasal anesthesia with lidocaine. Responses of the whole nerve activity of the PNN to these substances corresponded to the magnitude of the reflexes. These results indicate that PNN afferents play an important role on the reflex elicitation of the noxious, water and cold stimuli from the nasal cavity. (+info)Protective immune response against Streptococcus pyogenes in mice after intranasal vaccination with the fibronectin-binding protein SfbI. (4/2093)
Despite the significant impact on human health of Streptococcus pyogenes, an efficacious vaccine has not yet been developed. Here, the potential as a vaccine candidate of a major streptococcal adhesin, the fibronectin-binding protein SfbI, was evaluated. Intranasal immunization of mice with either SfbI alone or coupled to cholera toxin B subunit (CTB) triggered efficient SfbI-specific humoral (mainly IgG) and lung mucosal (14% of total IgA) responses. CTB-immunized control mice were not protected against challenge with S. pyogenes (90%-100% lethality), whereas SfbI-vaccinated animals showed 80% and 90% protection against homologous and heterologous challenge, respectively. Multiple areas of consolidation with diffused cellular infiltrates (macrophages and neutrophils) were observed in lungs from control mice; the histologic structure was preserved in SfbI-vaccinated animals, which occasionally presented focal infiltrates confined to the perivascular, peribronchial, and subpleural areas. These results suggest that SfbI is a promising candidate for inclusion in acellular vaccines against S. pyogenes. (+info)Central nervous system effects of intranasally administered insulin during euglycemia in men. (5/2093)
Insulin receptors have been detected in several structures of the brain, yet the biological significance of insulin acting on the brain remains rather unclear. In humans, direct central nervous effects of insulin are difficult to distinguish from alterations in neuronal functions because of insulin-induced decrease in blood glucose levels. Since several intranasally administered viruses, peptides, and hormones have been shown to penetrate directly from the nose to the brain, we tested whether insulin after intranasal administration likewise has access to the brain. After a 60-min baseline period, insulin (20 IU H-Insulin 100 Hoechst) or vehicle (2.7 mg/ml m-Cresol) was intranasally administered every 15 min to 18 healthy subjects according to a double-blind within-subject crossover design. Auditory-evoked potentials (AEP) indexing cortical sensory processing were recorded while the subjects performed a vigilance task (oddball paradigm) during the baseline phase and after 60 min of intranasal treatment with insulin or placebo. Blood glucose and serum insulin levels were not affected by intranasal insulin. Compared with placebo, intranasal administration of insulin reduced amplitudes of the N1 (P < 0.005) and P3 (P < 0.02) components of the AEP and increased P3 latency (P < 0.05). The reduction in P3 amplitude was most pronounced over the frontal recording site (2.42 +/- 1.00 vs. 4.92 +/- 0.79 microV, P < 0.0005). At this site, after insulin administration, a broad negative shift developed in the AEP between 280 and 500 ms poststimulus (area under the curve -166.0 +/- 183.8 vs. 270.8 +/- 138.7 microV x ms after placebo, P < 0.01). The results suggest that after intranasal administration, insulin directly enters the brain and exerts distinct influences on central nervous functions in humans. (+info)Lesions and transmission of experimental adenovirus hemorrhagic disease in black-tailed deer fawns. (6/2093)
Adenovirus infection was the cause of an epizootic of hemorrhagic disease that is believed to have killed thousands of mule deer (Odocoileus hemionus) in California during the latter half of 1993. A systemic vasculitis with pulmonary edema and hemorrhagic enteropathy or a localized vasculitis associated with necrotizing stomatitis/pharyngitis/glossitis or osteomyelitis of the jaw were common necropsy findings in animals that died during this epizootic. To study transmission of adenovirus infection in deer and susceptibility of black-tailed deer (Odocoileus hemionus columbianus) fawns to adenovirus infection, six 3-6-month-old black-tailed fawns were divided into two treatment groups. One group was inoculated intravenously and the other group was inoculated through the mucous membranes of the eyes, nose and mouth with purified adenovirus. Each treatment group also included two additional fawns (four total) that were not inoculated but were exposed to inoculated animals (contact animals). One fawn served as a negative control. Between 4 and 16 days postinoculation, 8/10 fawns developed systemic or localized infection with lesions identical to lesions seen in animals with natural disease that died during the epizootic. Transmission was by direct contact, and the route of inoculation did not affect the incubation period or the distribution of the virus (systemic or the localized infection). Immunohistochemical analysis using polyclonal antiserum against bovine adenovirus type 5 demonstrated staining in endothelial cells of vessels in numerous tissues in animals with systemic infection and endothelial staining only in vessels subtending necrotic foci in the upper alimentary tract in animals with the localized form of the disease. All inoculated or exposed animals had staining in the tonsillar epithelium. Transmission electron microscopic examination of lung and ileum from two fawns with pulmonary edema and hemorrhagic enteropathy demonstrated endothelial necrosis and adenovirus virions in endothelial cell nuclei. Adenovirus was reisolated in black-tailed deer pulmonary artery endothelial cells using lung homogenate of the first fawn that developed systemic adenovirus infection. Serum virus neutralization test results suggest that this deer adenovirus is a new serotype. (+info)Intranasally inoculated Mycoplasma hyorhinis causes eustachitis in pigs. (7/2093)
Specific-pathogen-free pigs were experimentally inoculated with Mycoplasma hyorhinis, Pasteurella multocida, or both bacterial isolates to evaluate the role of these bacteria in the pathogenesis of otitis media. Six pigs were inoculated intranasally with 4.4 X 10(8) colony-forming units (CFU) of M. hyorhinis. Twenty-one days later, three of these six pigs were inoculated intranasally with 5.0 X 10(8) CFU of P. multocida. Three additional pigs were also inoculated intranasally at the time with P. multocida alone. Two pigs served as uninoculated controls. Seven days later, all pigs were euthanatized. Histologically, subacute inflammation was found in 10 auditory tubes of six pigs and two tympanic cavities of two pigs inoculated with M. hyorhinis. Immunohistochemically, M. hyorhinis antigens were detected on the luminal surface of eight of 10 inflamed auditory tubes, and ultrastructural examination confirmed mycoplasmal organisms in two pigs. M. hyorhinis was isolated from the inflamed tympanic cavities of two pigs. None of the pigs inoculated only with P. multocida had otitis, and P. multocida was not isolated from the tympanic cavity. These findings indicate that M. hyorhinis can cause eustachitis but rarely otitis media in specific-pathogen-free pigs. (+info)Comparison of intranasal triamcinolone acetonide with oral loratadine in the treatment of seasonal ragweed-induced allergic rhinitis. (8/2093)
A double-blind, randomized, multicenter, parallel-group controlled study compared the efficacy and safety of intranasal triamcinolone acetonide (220 micrograms/day) and oral loratadine (10 mg/day) in patients with at least two seasons of ragweed-induced seasonal allergic rhinitis. A 28-day screening period, including a 5-day baseline period, preceded a 4-week treatment period. Reduction in rhinitis symptom scores was evident in both groups as early as day 1, with no significant between-group differences during week 1. At weeks 2, 3, and 4, patients treated with triamcinolone acetonide were significantly (P < 0.05) more improved in total nasal score, nasal itch, nasal stuffiness, and sneezing than were patients treated with loratadine. At weeks 3 and 4, rhinorrhea and ocular symptoms were significantly (P < 0.05) more improved from baseline among triamcinolone acetonide patients compared with loratadine patients. There was no significant between-group difference in relief from postnasal drip at any time point. Physicians' global evaluations significantly (P = 0.002) favored triamcinolone acetonide at the final visit, with moderate to complete relief of symptoms attained by 68% of triamcinolone acetonide patients and 59% of loratadine patients. Over the 4-week treatment period, triamcinolone acetonide patients had significantly greater improvement in total nasal score, nasal itch, nasal stuffiness, sneezing, and ocular symptoms. Both treatments were well tolerated, with headache being the most frequently reported drug-related adverse effect in both the triamcinolone acetonide (15%) and loratadine (11%) groups. These results indicate that triamcinolone acetonide is more effective than oral loratadine in relieving the symptoms of ragweed-induced seasonal allergic rhinitis. (+info)Laron, Z.; Frenkel, J.; Deghenghl, R.; Anin, S.; Klinger, B.; Siibergeld, A. (1995). "Intranasal administration of the GHRP". ... Frenkel, J.; Silbergeld, A.; Deghenghi, R.; Laron, Z. (1995). "Short Term Effect of Intranasal Administration of Hexarelin". ... intranasal, and oral administration in man". J Clin Endocrinol Metab. 78 (3): 693-8. doi:10.1210/jcem.78.3.8126144. PMID ... "Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone ...
"FDA approves Breo Ellipta to treat chronic obstructive pulmonary disease". Food and Drug Administration. May 10, 2013. "BREO® ... "Intranasal corticosteroids and adrenal suppression". Neuroimmunomodulation. 16 (5): 353-62. doi:10.1159/000216193. PMID ... is approved for use in the United States by the Food and Drug Administration for long-term maintenance treatment of airflow ...
Intranasal insulin is being investigated. A randomized controlled trial which will determine whether intranasal insulin can ... Administration schedules often attempt to mimic the physiologic secretion of insulin by the pancreas. Hence, both a long-acting ... In 2006 the U.S. Food and Drug Administration approved the use of Exubera, the first inhalable insulin. It was withdrawn from ... The insulin administration aspect remains experimental, but the blood glucose test aspect of "wrist appliances" is commercially ...
Increased levels of OT can be found in salivary samples after intranasal administration of the neuropeptide. Salivary OT levels ... Weisman, O., Zagoory-Sharon, O., & Feldman, R. (2012). Intranasal oxytocin administration is reflected in human saliva. ... Intranasal (IN) administration, as opposed to more conventional routes, such as oral or intravenous infusion, offers an ... A review of 38 randomized and controlled trials suggests that short-term use of intranasal oxytocin appears to have few side- ...
In addition, also unlike the case of peripheral administration, intranasal oxytocin has a central duration of at least 2.25 ... "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology. 37 (9): 1582-6. doi:10.1016/j. ... "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro ... Thus the fall in plasma concentration after the administration of a single dose is described by the following equation: C t = C ...
... since intranasal administration of oxytocin also increases envy and Schadenfreude. Individuals who receive an intranasal dose ... Theodoridou A, Penton-Voak IS, Rowe AC (2013). "A direct examination of the effect of intranasal administration of oxytocin on ... Shamay-Tsoory SG, Fischer M, Dvash J, Harari H, Perach-Bloom N, Levkovitz Y (November 2009). "Intranasal administration of ... Fischer-Shofty M, Shamay-Tsoory SG, Harari H, Levkovitz Y (January 2010). "The effect of intranasal administration of oxytocin ...
Fischer-Shofty M, Shamay-Tsoory SG, Harari H, Levkovitz Y (2010). "The effect of intranasal administration of oxytocin on fear ... "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology. 37 (9): 1582-6. doi:10.1016/j. ... "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro ... Intranasal oxytocin has a central duration of at least 2.25 hours and as long as 4 hours. Oral: Oxytocin is destroyed in the ...
... with rectal administration yielding the same results; intranasal varies between individuals with a mean of 46%. Taken orally, ... Therapeutic Goods Administration (June 2008). Standard for the uniform scheduling of drugs and poisons no. 23 (PDF). Canberra: ... Drug Enforcerment Administration. Retrieved 23 November 2015. "DEA Diversion Control CSA". US Dept of Justice - DEA. Retrieved ... In the United Kingdom, it is available in 10 mg/mL and 50 mg/mL formulation for intramuscular or intravenous administration. ...
Shamay-Tsoory SG, Fischer M, Dvash J, Harari H, Perach-Bloom N, Levkovitz Y (November 2009). "Intranasal administration of ... Some researchers have argued oxytocin has a general enhancing effect on all social emotions, since intranasal administration of ... 19 (7). Wudarczyk, O. A.; Earp, B. D.; Guastella, A; Savulescu, J (2013). "Could intranasal oxytocin be used to enhance ...
Preventing Anosmia from Intranasal Zinc Administration[unreliable medical source?] Maruyama T, Yasuda S, Odashiro K, Kaji Y, ... Intranasal drug use Samter's triad also known as AERD (aspirin exacerbated respiratory disease) Foster Kennedy syndrome Cadmium ... On June 16, 2009, the US Food and Drug Administration sent a warning letter to Matrixx Initiatives, manufacturer of an over-the ... Sarcoidosis Zinc-based intranasal cold products, including remedies labelled as "homeopathic" Chronic atrophic rhinitis Paget's ...
Rigg LA, Milanes B, Villanueva B, Yen SS (1977). "Efficacy of intravaginal and intranasal administration of micronized ... This route of administration is thus preferred in women with a history of thrombo-embolic disease. Estrogen is also used in the ... However, such risks have been found to vary depending on the type of estrogen or progestogen and the route of administration. ... It was only until 1941 when estrogen therapy was finally approved by the Food and Drug Administration (FDA) for the treatment ...
There are several methods of administration, including parenteral and intranasal. However, the intranasal method has been ... Several intranasal vaccines have been developed that contain canine adenovirus in addition to B bronchiseptica and canine- ... Administration of B. bronchiseptica and canine-parainfluenza vaccines may then be continued routinely, especially during ... Adverse effects of vaccinations are mild, but the most common effect observed up to 30 days after administration is nasal ...
Comparing Intranasal Administration to Intramuscular Administration in Healthy Human Volunteers." University of Kentucky ... "A single dose, Open Label, Randomized Three Way Crossover, Bioavailability Study of 1.0 mg and 2.0 Intranasal Butorphanol ... "A single Dose, Randomized Two Period Crossover Pharmacokinetic Study of 2.0 mg Intranasal Hydromorphone Hydrochloride In ...
... is also well absorbed following inhalation and following intranasal administration. It is distributed to most ... Methamphetamine is also well absorbed following inhalation and following intranasal administration. Due to the high ... Repeated administration or self administration of METH has been shown to upregulate σ-1 receptor protein and mRNA in various ... The lack of effect of administration of neomycin to one patient indicates that the hydroxylation occurs in body tissues. ... a ...
The bioavailability of doxylamine is 24.7% for oral administration and 70.8% for intranasal administration. The Tmax of ... "Comparative pharmacokinetics of single doses of doxylamine succinate following intranasal, oral and intravenous administration ... Doxylamine succinate is generally safe for administration to healthy adults. The median lethal dose (LD50) is estimated to be ...
"Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration". Eur ... Unlike the case of oral administration, transdermal administration of 30 mg/day pregnenolone cream has not been found to affect ... Oral administration of 50 or 100 mg pregnenolone has been found to have minimal or negligible effect on urinary levels of ... In further research by their group, a single 400 mg dose of oral pregnenolone at 3 hours post-administration was found to ...
Its bioavailability is 2.5 to 3.3% by intranasal administration and 70% by subcutaneous injection. The plasma protein binding ... With chronic administration of buserelin however, the GnRH receptor becomes desensitized and completely stops responding both ... The elimination half-life of buserelin regardless of route of administration is about 72 to 80 minutes. Buserelin and its ... Trabant H, Widdra W, de Looze S (1990). "Efficacy and safety of intranasal buserelin acetate in the treatment of endometriosis ...
"Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration". Eur ... In accordance, acute administration of low doses of micronized progesterone (which reliably elevates allopregnanolone levels), ... "Investigations on changes in ¹³C/¹²C ratios of endogenous urinary steroids after pregnenolone administration". Drug Test Anal. ... "Urinary marker of oral pregnenolone administration". Steroids. 70 (3): 179-83. doi:10.1016/j.steroids.2004.12.007. PMID ...
Intranasal esketamine, an enantiomer of ketamine, is in the final stages of development for depression. The antidepressant ... A low dose of ketamine administration initiates three rapidly consecutive events, a presynaptic disinhibition of glutamatergic ... the antidepressant effects of euphoriants quickly disappear with chronic administration due to tachyphylaxis. Moreover, these ... discovered that low doses of the general anesthetic ketamine rapidly reduce depressive symptoms within hours of administration ...
Levine, A. I., & Bryson, E. O. (2010). Intranasal self-administration of remifentanil as the foray into opioid abuse by an ... Panlilio, L. V., & Schindler, C. W. (2000). Self-administration of remifentanil, an ultra-short acting opioid, under continuous ... Comparison of remifentanil or fentanyl administration during isoflurane anesthesia for coronary artery bypass surgery. Med Sci ... US Food and Drug Administration. (2010). Orange book: approved drug products with therapeutic equivalence evaluations. Silver ...
Vincent AL, Ma W, Lager KM, Janke BH, Webby RJ, Garcia-Sastre A, Richt JA (2007). "Efficacy of intranasal administration of a ...
"Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo". Doklady Biological ...
Clausi, M.G.; Paez, P.M.; Campagnoni, A.T.; Pasquini, L.A.; Pasquini, J.M.; Ahmadiani, A. (2012). "Intranasal administration of ... It has been shown that intranasal administration of aTf (apotransferrin) can protect myelin and induce remyelination. Much of ...
Intranasal mometasone alleviates symptoms such as rhinorrhea aquosa, nasal congestion, nasal drip, sneezing, and pharyngeal ... Topical administration applied to skin reduces the inflammation associated with chronic or acute dermatosis. Extensive ... As of 2016 mometasone furoate was available worldwide in formulations for nasal, oral inhalation, and topical administration, ... Blaiss, MS (2011). "Safety update regarding intranasal corticosteroids for the treatment of allergic rhinitis". Allergy and ...
Sublingual administration (under the tongue) is usually superior to swallowing for bioavailability and effects; however, ... Coda BA, Rudy AC, Archer SM, Wermeling DP (July 2003). "Pharmacokinetics and bioavailability of single-dose intranasal ... A particular problem that may occur with hydromorphone is accidental administration in place of morphine due to a mix-up ... Gagnon, DJ; Jwo, K (2013). "Tremors and agitation following low-dose intravenous hydromorphone administration in a patient with ...
The optimal formulation of zinc lozenges and an ideal frequency of their administration should be examined. Given the evidence ... the safety of intranasal zinc has been called into question because of numerous reports of anosmia (loss of smell), in some ... Intranasal ipratropium bromide for the common cold,url=,journal=The Cochrane Database of Systematic Reviews,language=en,volume ... Loss of Sense of Smell with Intranasal Cold Remedies Containing Zinc,year=2009,url-status=live,archiveurl=https://web.archive. ...
2014). Intranasal administration as a route for drug delivery to the brain: Evidence for a unique pathway for albumin. The ... Evgenev M.B., Garbuz D.G., Morozov A.V., Bobkova N.V. (2018) Intranasal Administration of Hsp70: Molecular and Therapeutic ... Taken together, our findings establish intranasal administration of exogenous human Hsp70 as a practical therapeutic approach ... 2008). Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and ...
A composition and method for nasal administration of pharmaceuticals utilizes glycyrrhetinic acid as an absorption enhancer. ... The intranasal administration of vitamin B-12 is illustrated as follows.. 1 ml of a vitamin B-12 solution containing 1,000μg/ml ... The intranasal administration of human ACTH is illustrated as follows.. A 0.5% (w/v) 18β-glycyrrhetinic acid vehicle solution ... Pharmaceutical preparations for intranasal administration. US5989582 *. 14 Feb 1996. 23 Nov 1999. Weg; Stuart L.. ...
... the potential side-effects of intranasal oxytocin have remained largely unclear to date.... ... use of intranasal oxytocin administration in children, the potential side-effects of intranasal oxytocin have remained largely ... Oxytocin Side-effects Middle childhood Randomized controlled trial Intranasal administration This is a preview of subscription ... The current study suggests that single administration of intranasal oxytocin is likely safe in elementary school-aged children. ...
Intranasal Self-Administration of Remifentanil as the Foray into Opioid Abuse by an Anesthesia Resident. Levine, Adam I., MD; ... Intranasal Self-Administration of Remifentanil as the Foray into Opioid Abuse by an Anesthesia Resident ... The effect of intranasal administration of remifentanil on intubating conditions and airway response after sevoflurane ... On further questioning, he admitted to IV administration of fentanyl, which he had begun using several weeks prior. He reported ...
... ... We aimed at testing the immunomodulatory effects of intranasal versus intragastric administration of Lactobacillus paracasei ... A concerted selection of intervention schedule, doses, and administration routes (intranasal versus intragastric) may markedly ... Intranasal L. paracasei NCC2461 efficiently protected sensitized mice upon exposure to OVA aerosols in a dose-dependent manner ...
A Study of Diazepam After Intranasal and Intravenous Administration to Healthy Volunteers. This study has been completed. ... A Study of Diazepam After Intranasal and Intravenous Administration to Healthy Volunteers. ... It was approved by the Food and Drug Administration (FDA) for use in the United States and is currently sold as Valium® tablets ... Positive serum pregnancy test at Screening or urine pregnancy test prior to each administration of study drug for all women, ...
Drug: Epinephrin (Intranasal injection) Drug: Epinephrin (Topical administration) Hide Detailed Description Detailed ... Intranasal Injection Versus Topical Administration of Epinephrin During Endoscopic Sinus Surgery. The safety and scientific ... Active Comparator: Topical administration An an intranasal injection of saline will be used as control, and thereafter cotton ... Drug: Epinephrin (Topical administration) An intranasal injection of saline solution, followed by placement of cotton pledgets ...
We have previously shown that intranasal (i.n.) administration of a single MHC class II-restricted HY peptide to female mice ... Molecular Mechanisms of Induction of Antigen-Specific Allograft Tolerance by Intranasal Peptide Administration. Katy Derbyshire ... Molecular Mechanisms of Induction of Antigen-Specific Allograft Tolerance by Intranasal Peptide Administration ... Molecular Mechanisms of Induction of Antigen-Specific Allograft Tolerance by Intranasal Peptide Administration ...
Intranasal administration of ML-HSA before RSV infection resulted in significant decrease of the viral titers in the lungs of ... ML-HSA shows promise for further development into an effective, safe, affordable, and easy-to-use intranasal regimen for pre- ... Sun Z, Wang Q, Jia R, Xia S, Li Y, Liu Q, Xu W, Xu J, Du L, Lu L, Jiang S. Intranasal Administration of Maleic Anhydride- ... Intranasal administration of ML-HSA before RSV infection resulted in significant decrease of the viral titers in the lungs of ...
... after intranasal administration of Asari Radix et Rhizoma (AR). In total, 47 absorbed AR constituents including 14 monoterpenes ... and comprehensively analyze the absorbed constituents after intranasal administration of TCM. These findings extend our ... Keywords: nasal therapy; Asarum heterotropoides var. mandshuricum; intranasal administration; effective substance; ... Identification of Absorbed Constituents in the Rabbit Plasma and Cerebrospinal Fluid after Intranasal Administration of Asari ...
Discover how intranasal administration of the opioid reversal agent naloxone fared as compared with IV administration. ... Intranasal Naloxone Administration in Dogs. Travis Lanaux, DVM, DACVECC, University of Florida ... Naloxone half-life was similar for both routes of administration (IV, 37 ± 6.7 minutes; intranasal, 47.4 ± 6.7 minutes). It is ... Naloxone was detectable in plasma 2.3 ± 1.4 minutes after intranasal administration; mean time to maximum concentration in ...
These findings suggest that intranasal insulin administration could be an effective approach to prevent the increased risk of ... These findings suggest that intranasal insulin administration could be an effective approach to prevent the increased risk of ... Importantly, insulin administered through intranasal delivery prior to anesthesia was found to prevent the anesthesia-induced ... Importantly, insulin administered through intranasal delivery prior to anesthesia was found to prevent the anesthesia-induced ...
Intranasal administration of neural stem cell-mediated enzym/prodrug therapy using a novel HSV-thymidine kinase variant ... Those receiving additional intranasal administration of NSC-TK007 displayed a significant tumor growth inhibition of 81% versus ... Here, we demonstrate that the non-invasive intranasal administration of tumor-targeting NSC is able to deliver a novel suicide ... Therapeutic effects of intratumoral (3x105 cells) and intranasal (1.5x106) NSC-TK007 application alone and the sequential ...
Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water ... Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water ... Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water ... Activity-Dependent Neurotrophic Factor: Intranasal Administration of Femtomolar-Acting Peptides Improve Performance in a Water ...
... by intranasal route, or by intradermal, intramuscular or subcutaneous injection for the ... CERTIFICATION FOR DRUG ADMINISTRATION BY INJECTION AND INTRANASAL ROUTE Effective December 3, 2015, the Ministry of Health made ... They must complete the intranasal administration online module and complete the "intranasal administration declaration" through ... Apply for Drug Administration Submit the Application for Certification - Drug Administration by Injection and Intranasal Route ...
Figure S1 Cine of 3-dimensional reconstruction of dynamic PET data after [18F]FLT intranasal administration co-registered with ... Figure S2 Cine of 3-dimensional reconstruction of dynamic PET data after [18F]FLT intranasal administration co-registered with ... Pharmacoimaging of Blood-Brain Barrier Permeable (FDG) and Impermeable (FLT) Substrates After Intranasal (IN) Administration. ... This product is modified to meet the requirements for administration to small animals. A 1.5-2.0 mL sample is withdrawn from ...
Intranasal administration of oxytocin decreases task-related aggressive responses in healthy young males. Publication. ... Intranasal administration of oxytocin decreases task-related aggressive responses in healthy young males. ... In this randomized double-blind, placebo-controlled study, the effects of intranasal oxytocin (32IU) on taskrelated aggressive ... Our results indicate that oxytocin administration reduces aggressive behavior in healthy young men. Moreover, increased ...
Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection by Schistosoma mansoni T ... Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection by Schistosoma mansoni ... Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection by Schistosoma mansoni ... Intranasal Administration of Synthetic Recombinant Peptide-Based Vaccine Protects Mice from Infection by Schistosoma mansoni ...
intranasal administration. absorption enhancing. administration containing. enhancing system. Prior art date. 1986-12-16. ... Device for intranasal administration UY32514A (en) 2009-03-27. 2010-10-29. Glaxo Group Ltd. MERGERS & Conjugates of a drug ... Insulin preparation for intranasal administration NL193099C (en) * 1981-10-30. 1998-11-03. Novo Industri As. Stabilized insulin ... Therapeutic compositions for intranasal administration comprising ketorolac. DK36492D0 (en) * 1992-03-19. 1992-03-19. Novo ...
Intranasal Administration of an Inactivated Yersinia pestis Vaccine with Interleukin-12 Generates Protective Immunity against ... Intranasal Administration of an Inactivated Yersinia pestis Vaccine with Interleukin-12 Generates Protective Immunity against ... Intranasal Administration of an Inactivated Yersinia pestis Vaccine with Interleukin-12 Generates Protective Immunity against ... Intranasal Administration of an Inactivated Yersinia pestis Vaccine with Interleukin-12 Generates Protective Immunity against ...
Intranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A ... We concluded that intranasal imiquimod facilitates a more effective immune response, which can limit the pathology associated ... In mice, daily intranasal delivery of imiquimod prevented peak viral replication, bodyweight loss, airway and pulmonary ... In the present study, we examined the effect of intranasal delivery of the TLR7 agonist, imiquimod or its topical formulation ...
Free resource for searching and exporting immune epitopes. Includes more than 95% of all published infectious disease, allergy, autoimmune, and transplant epitope data.
... Pharmaceutical ... Intranasal Drug Delivery - Away from Needles. In the current scenario, although needle-based injections are the most common ... Further, as emerging intranasal delivery technologies eliminate the use of needles, there is no risk of needle-stick problems. ... The shortcomings of needle-based injections along with fear among patients has led to the onset of novel needleless intranasal ...
Administration. *Draw up appropriate dose for weight (see table below) plus 0.1ml extra to the first dose (to account for the ... Intranasal fentanyl. * See also. Acute pain management. Indications for use. *Initial analgesia for children aged 1 year and ... Patients receiving intranasal fentanyl will be monitored like a patient receiving IV or IM opioids such as morphine (RCH ... Baseline set of observations prior to drug administration.. *The patient should be awake or easily roused to voiceprior to each ...
The intranasal influenza vaccine is not absorbed systemically after intranasal administration and use during pregnancy is not ... The intranasal influenza vaccine is not absorbed systemically after intranasal administration and use during pregnancy is not ... There are no data regarding concurrent intranasal corticosteroid administration and the use of intranasal influenza vaccine.[ ... Prior to the administration of the intranasal influenza vaccine, health care personnel should inform the patient, parent, ...
ImmunizationSprayVaccineSubcutaneous administrationRoutesCorticosteroidsSingle dose of intranasalVaccines0.05MidazolamSuggest that intranasalAnesthesiaFound that intranasalPharmacokinetics of IntranasalTherapeuticPeptideDaily intranasalHalf life of 1.72OralAllergic RhinitisAnalgesiaVaccinationInsulin administrationTetracaineFentanyl for painRouteOnsetTopicalDrugEffectsMeSHInterventionsInfectionFindingsSedation scoreAcuteExperimentalCONCLUSIONSTreatmentBlood-brain bDexmedetomidineEffectStudyDiamorphineLungsPharmacodynamicsDeliveryClinicalTolerabilityKetamine
- Following i.n. peptide plus LPS administration, causing immunization, HY-specific CD4 + T cells express genes characteristic of activated T cells. (jimmunol.org)
- Recently, intranasal (i.n.) immunization of mice with a recombinant BCG strain expressing GST was reported to induce humoral responses as well as antibodies which neutralized the enzyme activity ( 12 ). (asm.org)
- Proper vaccine administration is a critical component of a successful immunization program. (cdc.gov)
- To determine how the route of immunization affects CD8+ T cell responses in the lungs of mice vaccinated with a murine cytomegalovirus vector expressing the respiratory syncytial virus matrix (M) protein, we infected CB6F1 mice via the intranasal or intraperitoneal route and evaluated the M-specific CD8+ T cell response at early and late time points. (edu.au)
- In this paper, nontoxic Escherichia coli heat-labile enterotoxin (LT) mutants and Supramolecular Biovector systems (SMBV) were evaluated in mice as mucosal adjuvants and delivery systems, respectively, for intranasal immunization with the conjugated group C meningococcal vaccine. (asm.org)
- The current study is the first double-blind randomized controlled trial to examine side-effects following single administration of oxytocin nasal spray in elementary school-aged children. (springer.com)
- We assessed side-effects by means of a standardized, drug-specific questionnaire and an open-ended question at two time points: 90 min after nasal spray administration and 24 h after administration. (springer.com)
- In response, we have developed a novel pneumatically driven IN spray device for the administration of NPs, which is capable of administering extremely small quantities (50-100 μ l) of NP suspension in a fine spray that disperses the NPs uniformly onto the tissue. (asme.org)
- IN administration of STL-functionalized NPs using the IN spray device increased brain tissue haloperidol concentrations by a factor of 1.2-1.5× compared to STL-functionalized NPs administered IN with a pipette. (asme.org)
- Our results are disappointing, however, the efficacy of the intranasal spray of oxytocin is still an issue of controversy. (nii.ac.jp)
- Objective To compare two spray administration of intranasal dexmedetomidine (DEX) doses for premedication in children. (actacams.com)
- Children were assigned to receive either spray administration of intranasal DEX 1 μg/kg (Group D1) or 2 μg/kg (Group D2). (actacams.com)
- In Group D2,the HR decreased by 15.8% ( t =2.415, P =0.021) 30 min after the spray administration of intranasal DEX. (actacams.com)
- t =-1.096, P =0.280)and HR in group D1 ( t =-0.299, P =0.767) 30 min after the spray administration of intranasal DEX. (actacams.com)
- Conclusion Spray administration of intranasal DEX 2 μg/kg provides superior sedation in children. (actacams.com)
- Comparison of Sedative Effects of Two Spray Administration of Intranasal Dexmedetomidine Doses for Premedication in Children[J].Acta Academiae Medicinae Sinica, 2016, 38(5): 563-567. (actacams.com)
- Primosch RE,Guelmann M.Comparison of drops versus spray administration of intranasal midazolam in two-and three-year-old children for dental sedation[J]. Pediatr Dent,2005,27(5):401-408. (actacams.com)
- When can desmopressin vasopressin analog be administered by intranasal spray for the treatment of hemophilia A? (medscape.com)
- A concentrated DDAVP intranasal spray is available for outpatient use. (medscape.com)
- The advantages of advanced intranasal vaccine delivery technologies over the existing treatments has created lucrative opportunities for drug manufacturers. (futuremarketinsights.com)
- Prior to the administration of the intranasal influenza vaccine, health care personnel should inform the patient, parent, guardian, or responsible adult of the vaccine's benefits and risks. (pdr.net)
- According to U.S. federal laws, the health care provider must record in the patient's permanent record: the manufacturer, lot number, date of administration, and the name and address of the person administering the vaccine. (pdr.net)
- Visually inspect the vaccine before administration. (pdr.net)
- If the vaccine recipient sneezes after administration, do not repeat the dose. (pdr.net)
- Single-dose vials and manufacturer-filled syringes are designed for single-dose administration and should be discarded if vaccine has been withdrawn or reconstituted and subsequently not used within the time frame specified by the manufacturer. (cdc.gov)
- The FDA does not license administration syringes for vaccine storage. (cdc.gov)
- For administration of routinely recommended vaccines, there is no evidence of risk of exposure of vaccine components to the health care provider, so conditions in the provider labeled as contraindications and precautions to a vaccine components are not a reason to withdraw from this function of administering the vaccine to someone else. (cdc.gov)
- This chapter provides best practice guidance for vaccine administration. (cdc.gov)
- The guidance should be used in conjunction with professional standards for medication administration and guidance from the vaccine manufacturer. (cdc.gov)
- All personnel who will administer vaccines should receive comprehensive, competency-based training regarding vaccine administration policies and procedures before administering vaccines. (cdc.gov)
- Providers need to validate staff's knowledge and skills regarding vaccine administration with a skills checklist. (cdc.gov)
- Staff should receive ongoing education, such as whenever vaccine administration recommendations are updated, or when new vaccines are added to the facility's inventory, to maintain staff competency. (cdc.gov)
- NDV has the potential for further development as a pretested, highly attenuated, intranasal vector to be available for expedited vaccine development for humans, who generally lack preexisting immunity against NDV. (pnas.org)
- This study showed the mechanism of the protective effect of intranasal vaccination of PPR vaccine observed with the strong mucosal and defensive cellular responses in the respiratory tract observed than the subcutaneous and intramuscular routes. (bvsalud.org)
- Significant rises in total IgE and the presence of IgE-omalizumab complexes were seen with subcutaneous administration of omalizumab. (medicalxpress.com)
- A concerted selection of intervention schedule, doses, and administration routes (intranasal versus intragastric) may markedly contribute to modulate airway inflammation in a probiotic strain-specific manner. (hindawi.com)
- However, alternative routes, in particular IN administration, may provide benefits relative to oral dosing. (biomedcentral.com)
- Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider. (psu.edu)
- It is not unequivocally proven whether a combination of an intranasal corticosteroids (INSs) and a cysteinyl leukotriene receptor antagonist has greater efficacy than INSs in the treatment of seasonal. (bioportfolio.com)
- In the current placebo-controlled, double blind experiment on healthy adult male subjects the investigators will measure the effects of a single dose of intranasal oxytocin (24IU) on brain activity (using electroencephaolography - EEG) as well as on cardiac (heart-rate and heart-rate variablility) and gastric (electrogastrogram - EGG) activity and physiological arousal (skin conductance response - SCR). (trialbulletin.com)
- In the current scenario, although needle-based injections are the most common route of drug delivery and administration of vaccines, the trend is witnessing a rapid change. (futuremarketinsights.com)
- Hands should be cleansed with an alcohol-based waterless antiseptic hand rub or washed with soap and water before preparing vaccines for administration and between each patient contact ( 1 ). (cdc.gov)
- Because the majority of vaccines have a similar appearance after being drawn into a syringe, prefilling might result in administration errors. (cdc.gov)
- Improper administration of vaccines may result in injuries or prevent the vaccines from providing optimal protection. (cdc.gov)
- These data strongly support the feasibility of development of intranasal vaccines with an enhanced protective efficacy against meningococci and possibly against other encapsulated bacteria. (asm.org)
- After restraint, the parrots received intranasal flumazenil (0.05 mg/kg) or an equal volume of saline solution, and the recovery time was recorded. (elsevier.com)
- Objectives: This study evaluated the cardiovascular effects and pharmacokinetics of intranasal 3% tetracaine/0.05 % oxymetazoline, being developed to provide needle-free anesthesia of maxillary teeth. (umich.edu)
- Administration of intranasal midazolam (2 mg/kg) was evaluated for sedation and effects on cloacal temperature, respiratory rate, and heart rate in manually restrained Hispaniolan Amazon parrots (Amazona ventralis). (elsevier.com)
- In those birds that received midazolam, sedation was observed within 3 minutes of administration, and vocalization, flight, and defense responses were significantly reduced during capture. (elsevier.com)
- No overt clinical adverse effects to intranasal midazolam and flumazenil administration were observed. (elsevier.com)
- Further studies on the safety of intranasal midazolam and flumazenil in this species are warranted. (elsevier.com)
- Primosch RE,Bender F.Factors associated with administration route when using midazolam for pediatric conscious sedation[J]. ASDC J Dent Child,2001,68(4): 233-238,228. (actacams.com)
- 9-11 ] However, the effect of intranasal midazolam on recovery of ambulatory pediatric surgical patients has not been evaluated. (asahq.org)
- This study evaluated the effects of intranasal midazolam on anesthesia recovery and hospital discharge times, parent/child separation, and smoothness of the anesthetic induction in children undergoing myringotomy and tube insertion. (asahq.org)
- Objective- This study aimed to compare sedation efficacy in intranasal administration of xylazine, diazepam and midazolam with or without ketamine in Chough. (ivsajournals.com)
- 3,4 Intranasal administration of xylazine, midazolam and diazepam has been reported in some species of bird such as pigeons and canaries. (ivsajournals.com)
- These findings suggest that intranasal insulin administration could be an effective approach to prevent the increased risk of neurotoxicity and chronic damage caused by anesthesia in the developing brain. (frontiersin.org)
- However, there is limited available evidence to suggest that intranasal fentanyl may provide similar analgesia to intravenous morphine in the Emergency Department. (bestbets.org)
- Importantly, insulin administered through intranasal delivery prior to anesthesia was found to prevent the anesthesia-induced long-term behavioral abnormalities, reduction of PSD95, and activation of neuronal apoptosis. (frontiersin.org)
- Experimental intranasal (IN) delivery of nanoparticle (NP) drug carriers is typically performed using a pipette with or without anesthesia, a technique that may be a poor simulation of practical IN administration of drug-loaded NPs in humans. (asme.org)
- The safety profile and pharmacokinetics of this intranasal formulation indicate that it appears to be generally well tolerated in patients for achieving anesthesia of the maxilla. (sigmaaldrich.com)
- Results - Fallowing intranasal administration of the subjects, sedation or anesthesia was produced in all groups. (ivsajournals.com)
- The researchers found that intranasal challenge with Bet v 1 induced increases of Bet v 1-specific IgE levels by a median of 59.2 percent, which was significantly more than in the other treatment groups. (medicalxpress.com)
- We found that intranasal vaccination generated robust and durable tissue-resident effector and effector memory CD8+ T cell populations that were undetectable after intraperitoneal vaccination. (edu.au)
- However, the pharmacokinetics of intranasal ketorolac when administered in children has only been described in a limited fashion. (clinicaltrials.gov)
- Taken together, our findings establish intranasal administration of exogenous human Hsp70 as a practical therapeutic approach for the treatment of various neurodegenerative diseases and aging. (springer.com)
- Despite growing interest in the (therapeutic) use of intranasal oxytocin administration in children, the potential side-effects of intranasal oxytocin have remained largely unclear to date. (springer.com)
- Intranasal application of the neuropeptide oxytocin has been reported to produce a number of neural, physiological and behavior effects which may be of potential therapeutic relevance, but it is unclear the extent to which they are mediated directly via the peptide entering the brain or indirectly as a result of increased peripheral concentrations. (trialbulletin.com)
- We also investigated the therapeutic effect of an intranasal steroid on OD. (bioportfolio.com)
- The intention of this Viewpoint is to deliberate if an enhanced therapeutic effect may be accomplished via the administration of drug therapy through the nasal cavity traversing the cribriform plate to access the brain, for COVID-19 cases with the central nervous system involvement. (curofy.com)
- In a submission to the Therapeutic Goods Administration , a Novartis representative concluded, "The justification was not based on evidence. (rug.nl)
- Intranasal TGF-β1 may have therapeutic potential for cerebrovascular disorders. (biomedcentral.com)
- In this study, we investigated the molecular mechanisms involved both in the induction phase following peptide administration and during linked suppression after grafting. (jimmunol.org)
- We report that following initial i.n. administration, peptide is widely disseminated and is presented by functionally immature dendritic cells. (jimmunol.org)
- Rangasamy SB, Corbett GT, Roy A, Modi KK, Bennett DA, Mufson EJ, Ghosh S, Pahan K. Intranasal Delivery of NEMO-Binding Domain Peptide Prevents Memory Loss in a Mouse Model of Alzheimer's Disease. (rush.edu)
- This study aims to dissociate direct from indirectly mediated effects of intranasal oxytocin administration by using treatment with or without prior intranasal administration of a vasoconstrictor to reduce peripheral increases in peptide concentrations. (trialbulletin.com)
- Short Term Effect of Intranasal Administration of Hexarelin - A Synthetic Growth Hormone-Releasing Peptide. (degruyter.com)
- Objective: We used light microscopy to search for local changes of the nasal mucosa associated with daily intranasal administration of mometasone furoate (MF), azelastine (AZ) or salmon calcitonin (SC). (ent-review.com)
- Oxymetazoline concentrations from the two-times-MRD administration were approximately 50 percent greater than those from the MRD administration, with a half-life of 1.72 to 2.32 hours. (sigmaaldrich.com)
- Intranasal administration may be preferable to oral for individuals experiencing nausea and/or vomiting, although it is primarily absorbed in the gut, not the nasal mucosa. (ox.ac.uk)
- In such patients, mild-to-moderate hypoglycemia (blood glucose 50-70 mg/dL) occurs frequently and responds in most cases to oral carbohydrate administration ( 2 , 3 ). (diabetesjournals.org)
- In the most severe hypoglycemic events, administration of oral carbohydrate by a second party is precluded because the patient is combative, unconscious, or having a seizure. (diabetesjournals.org)
- Oral/intranasal H1-antihistamine, decongestants, leukotriene receptor ant. (bioportfolio.com)
- After oral or intranasal (i.n.) delivery, vaccination with these mutants as adjuvants induced appropriate immune effector mechanisms (antibodies, CD4 + helper T cells, and CD8 + cytotoxic T cells) able to confer protection against the relevant infectious challenge ( 23 ). (asm.org)
- Reversal of Olfactory Disturbance in Allergic Rhinitis Related to OMP Suppression by Intranasal Budesonide Treatment. (bioportfolio.com)
- The administration of IN ketorolac in children, using the proprietary SPRIX device, which atomizes a fixed amount of ketorolac, produces serum concentrations of ketorolac that are associated with analgesia. (clinicaltrials.gov)
- Intranasal administration of opiate analgesia has some potential advantages over intravenous morphine due to its ease of administration, rapid onset, shorter duration and the lack of histamine release. (bestbets.org)
- Intranasal opiates have the clear theoretical advantage of providing rapid analgesia to patients where cannulation is undesirable or impossible. (bestbets.org)
- It has the potential for self-administration, combined with a rapid onset of action, allowing for patient-controlled analgesia. (dovepress.com)
- Intranasal administration of pain medications provides rapid analgesia with minimal discomfort. (luriechildrens.org)
- To avoid pain and anxiety caused by IM injections in children, intranasal route have been evaluated for the induction of sedation or analgesia. (ivsajournals.com)
- Here, we show that, although intranasal vaccination with cationic liposomes in combination with antigenic protein elicited GM-CSF expression at the site of administration, blocking GM-CSF function by using an anti-GM-CSF neutralizing antibody did not alter antigen-specific antibody production induced by DOTAP/DC-chol liposomes, indicating that GM-CSF may not contribute to the mucosal adjuvant activity of the cationic liposomes when administered intranasally. (biomedcentral.com)
- The generation of these antigen-experienced cells by intranasal vaccination resulted in earlier T cell responses, interferon gamma secretion, and viral clearance after respiratory syncytial virus challenge. (edu.au)
- We aim to evaluate the acute and long-term effects of intranasal insulin administration in persons with bipolar disorder. (clinicaltrials.gov)
- As such we will be conducting the neuropsychological testing at three time points, the week before receiving insulin, within one hour of the first dose and after 8 weeks of insulin administration. (clinicaltrials.gov)
- Intranasal insulin administration was used as a neuroprotective and antidiabetic drug. (omicsonline.org)
- Conclusions: Intranasal tetracaine/oxymetazoline mist was generally well tolerated. (umich.edu)
- Tetracaine plasma levels were undetectable in most participants, whereas concentrations of its major metabolite parabutylaminobenzoic acid from the two-times-MRD administration were approximately twice that from the MRD administration. (sigmaaldrich.com)
- Objective: To determine whether intranasal ketamine is noninferior to intranasal fentanyl for pain reduction in children presenting with acute extremity injuries. (luriechildrens.org)
- Intranasal ketamine may be an appropriate alternative to intranasal fentanyl for pain associated with acute extremity injuries. (luriechildrens.org)
- A number of animal studies have shown the potential for remifentanil abuse, 2-4 but the relative complexity required for self-administration of the IV form of the drug makes this route impractical. (lww.com)
- The intranasal route rapidly achieved clinically useful plasma levels in healthy medium-sized dogs. (cliniciansbrief.com)
- however, there were no notable changes in behavior, heart rate, or respiratory rate following naloxone administration by either route in this study. (cliniciansbrief.com)
- Submit the Application for Certification - Drug Administration by Injection and Intranasal Route to the College. (bcpharmacists.org)
- Since during the invasion of the parasite into the host the schistosomula migrate first to the lungs, the intranasal route of administration was employed in order to halt the parasite at an early stage of the infection. (asm.org)
- According to the WHO guidelines for drug administration, the route of delivery must consist a single-use delivery system that is auto-disposal after use. (futuremarketinsights.com)
- Sumatriptan (intranasal route of administration) for acute migraine attacks in adults. (ox.ac.uk)
- Ketorolac can also be given by the intranasal (IN) route using a mucosal atomization device (MAD). (clinicaltrials.gov)
- Administered once by intranasal route using a mucosal atomization device. (clinicaltrials.gov)
- Using an intranasal administration route in a rat model of focal cerebral ischemia, we demonstrate that nose-to-brain delivery of FBP after middle cerebral artery occlusion (MCAO) surgery results in the delivery and retention of FBP in Fas-expressing ischemic areas of the brain. (nature.com)
- Intranasal administration of opiates remains a promising alternative to the intravenous route in the ED, but more research is required in order to provide an evidence-based recommendation for its implementation. (bestbets.org)
- Using the intranasal route, the drugs can reach the central nervous system via the porous cribriform plate as well as target the affected lungs. (curofy.com)
- Clinical administration of drugs via the intravenous route results in dilution of the drugs in the plasma. (curofy.com)
- In addition to the intravenous route, the use of intranasal route to administer drugs offers several advantages in the management of COVID-19 with neurological manifestations. (curofy.com)
- The intranasal route can dispense the drugs through the cribriform plate. (curofy.com)
- Future research should test the efficacy of the suggested intranasal route for drug administration, in addition to the intravenous route, in the management of COVID-19 involving neurological manifestations. (curofy.com)
- Of several newer delivery systems under development and investigation for the administration of opioids, the intranasal route has received a substantial amount of attention. (dovepress.com)
- The purpose of this review is to examine the role of the nasal route of opioid administration and examine the evidence base for the use of fentanyl intranasally. (dovepress.com)
- 4-8 ] Although nasal preanesthetic medications can cause irritation to the nasal mucosa and patient crying, its rapid and reliable onset of action, avoidance of painful injections, and ease of administration have made it a convenient way to premedicate children. (asahq.org)
- Evidence indicate that topical administration of epinephrine achieves similar hemostatic effects compared with injection of epinephrine, while avoiding systemic adverse effects. (clinicaltrials.gov)
- We wish to conduct a prospective controlled trial assessing the hemostatic and hemodynamic effects of intranasal injection compared to topical application of epinephrin during ESS, in order to evaluate whether the previous could be avoided due to its untoward effects. (clinicaltrials.gov)
- We hypothesize that topical administration of epinephrine provides a hemostatic effect not inferior to that of intranasal injection while minimizing hemodynamic instability during ESS. (clinicaltrials.gov)
- The objective of the current study is to compare the hemostatic and hemodynamic effects of intranasal injection versus topical application of epinephrin during ESS, in order to evaluate whether the previous could be avoided due to its untoward effects. (clinicaltrials.gov)
- In the present study, we examined the effect of intranasal delivery of the TLR7 agonist, imiquimod or its topical formulation Aldara, on the inflammation and pathogenesis caused by IAV infection. (flu.org.cn)
- 170 171 186 (See Topical Administration under Dosage and Administration. (drugs.com)
- 215 administration of a topical nasal decongestant may be necessary. (drugs.com)
- In the United States, oxymetazoline 1% cream is approved by the Food and Drug Administration for topical treatment of persistent facial erythema (redness) associated with rosacea in adults. (rug.nl)
- 6. The method of claim 5 , wherein the administration is in the form of inhalation or topical administration. (google.com)
- This anilidopiperidine analog of fentanyl was approved by the United States Food and Drug Administration and became commercially available in the United States in 1997. (lww.com)
- It was approved by the Food and Drug Administration (FDA) for use in the United States and is currently sold as Valium® tablets, Diazepam Injection and Diastat® rectal gel. (clinicaltrials.gov)
- Further development regarding certification of other drug administration is being explored by the College. (bcpharmacists.org)
- Note: Registrants who are currently authorized to administer immunizations by injection are not required to re-apply for drug administration. (bcpharmacists.org)
- This declaration must be submitted in order to keep drug administration certification. (bcpharmacists.org)
- Have successfully completed a CCCEP-accredited drug administration training program approved by the College as listed in Schedule C of the HPA Bylaws . (bcpharmacists.org)
- You must apply for certification for drug administration within 1 year of completing the drug administration program. (bcpharmacists.org)
- Registrants with drug administration certification must re-certify at the time of their registration renewal. (bcpharmacists.org)
- Authorized registrants must login to eServices and declare if they meet the drug administration re-certification requirements (see Renewal Requirements ). (bcpharmacists.org)
- The annual registration e-card, available on eServices , also indicates drug administration certification. (bcpharmacists.org)
- Pharmacists must receive this certification prior to providing drug administration services. (bcpharmacists.org)
- In addition, prominent market players are prioritizing product launches owing to the growing demand for novel intranasal drug delivery systems. (futuremarketinsights.com)
- Baseline set of observations prior to drug administration. (rch.org.au)
- DUBLIN , Aug. 13, 2019 /PRNewswire/ -- The "Intranasal Drug Delivery - Market Analysis, Trends, and Forecasts" report has been added to ResearchAndMarkets.com's offering. (yahoo.com)
- Intranasal drug delivery is an effective option for the treatment of Alzheimer's disease and other central nervous system disorders. (biomedcentral.com)
- Blood samples were drawn at baseline and for two hours following drug administration. (umich.edu)
- The following Drug Information is provided by the indicated manufacturer and has been approved by the U.S. Food and Drug Administration. (druginfonet.com)
- Food and Drug Administration. (wikipedia.org)
- We reviewed evidence on the effect of intranasal fentanyl (INF) (a strong pain relief drug, similar to morphine ) compared with any other pain-relieving technique for treatment of children in acute severe pain. (cochrane.org)
- Heart rate (HR) and saturation of peripheral oxygen (SpO 2 ) were recorded before and every 15 min after drug administration. (actacams.com)
- Vyas TK,Shahiwala A,Marathe S,et al.Intranasal drug delivery for brain targeting[J]. Curr Drug Deliv,2005,2(2):165-175. (actacams.com)
- INP105 intranasal, with the active anti-psychotic drug olanzapine, is in clinical trials to test safety, tolerability, and pharmacodynamics/pharmacokinetics (PD/PK) of the drug. (in-pharmatechnologist.com)
- Impel further explained that intranasal drug delivery is beneficial for rapid response because the nasal cavity is vascular, ideal for drug deposition and absorption. (in-pharmatechnologist.com)
- Anesthetic techniques: transmucosal drug administration. (asahq.org)
- They drew blood samples at baseline and 15 times during the two hours after drug administration. (sigmaaldrich.com)
- The Food and Drug Administration places oxymetazoline in category C , indicating risk to the fetus cannot be ruled out. (rug.nl)
- Substance Abuse and Mental Health Services Administration, Results from the 2011 National Survey on Drug Use and Health: Summary of National Findings, NSDUH Series H-44, HHS Publication No. (SMA) 12-4713. (medscape.com)
- however, injecting needle to pectoral muscle may cause inadvertent intravascular or intracoelomic drug administration. (ivsajournals.com)
- MacDonald E, Dadds MR, Brennan JL, Williams K, Levy F, Cauchi AJ (2011) A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research. (springer.com)
- We aimed at testing the immunomodulatory effects of intranasal versus intragastric administration of Lactobacillus paracasei NCC2461 in a mouse model of allergic airway inflammation and the specificity of different probiotics by comparing L. paracasei NCC2461 to Lactobacillus plantarum NCC1107. (hindawi.com)
- Salivary oxytocin, cortisol and testosterone were measured serially prior to the intervention, and then before and after the PSAP, to evaluate the effects of oxytocin administration on hormonal functioning in relation to aggression. (eur.nl)
- Effects of intranasal oxytocin on steroid hormones in men and women. (rush.edu)
- Comparison of Intranasal Oxytocin Effects Using Co-administration With a. (trialbulletin.com)
- The pattern of functional effects observed will be compared with subjects receiving intranasal pretreatment with a vasoconstrictor prior to oxytocin in order to reduce the amount of oxytocin entering the peripheral circulation. (trialbulletin.com)
- A partial and reversible tolerance to the GH-releasing effects of examorelin occurs in humans with long-term administration (50-75% decrease in efficacy over the course of weeks to months). (wikipedia.org)
- Effects of intranasal oxytocin administration on memory f. (au.dk)
- Our findings add to a growing body of literature showing that the effects of intranasal oxytocin on memory and social behavior are moderated by adverse early life experiences. (au.dk)
- The sedative effects of intranasal dexmedetomidine, ketamine and morphine combination were evaluated in young dogs. (journalcra.com)
- Administration (intracerebroventricular) of OXT significantly antagonized the inhibitory effects of chronic complicated stress (CCS) on GI dysmotility in rats. (bvsalud.org)
- The effects of intranasal OXT on hypothalamus-pituitary-adrenal axis and GI motility in CCS conditions have not been investigated. (bvsalud.org)
- Intranasal administration of OXT has an anxiolytic effect and attenuates the hypothalamus-pituitary-adrenal axis in response to CCS, and gave effects which helped to restore GI dysmotility, and might be a new approach for the treatment of stress-induced GI motility disorders. (bvsalud.org)
- Administration, Intranasal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
- Interventions: Intranasal ketamine (1.5 mg/kg) or intranasal fentanyl (2 microg/kg). (luriechildrens.org)
- ML-HSA shows promise for further development into an effective, safe, affordable, and easy-to-use intranasal regimen for pre-exposure prophylaxis of RSV infection in children at high risk in both low- and high-income countries. (mdpi.com)
- We concluded that intranasal imiquimod facilitates a more effective immune response, which can limit the pathology associated with influenza A virus infection. (flu.org.cn)
- Most importantly, our findings establish the intranasal application of therapeutically-modified NSC as a safe and non-invasive application method. (egms.de)
- These findings indicate that intranasal nerve growth factor can bypass blood-brain barrier and affect spinal cord neurons in spinal cord injury. (eurekalert.org)
- Heart rate, respiratory rate, oxygen saturation, pain score & sedation score every 5 minutes after administration. (rch.org.au)
- The available literature suggests that the acute administration of intranasal insulin enhances cognition in memory impaired older adults with either Alzheimer's disease or minimal cognitive impairment. (clinicaltrials.gov)
- We show here that the RSV-specific IgA NALT plasma cell population and lung antibody levels can be substantially boosted, both at acute and memory time points, by intranasal immunisation with inactivated RSV (iRSV) in combination with bacterial outer membrane vesicles (OMV) compared to live RSV alone. (wiley.com)
- This is the first experimental study on the effect of oxytocin administration on the neural processing of facial stimuli conducted with female participants that uses event-related potentials (ERPs). (isharonline.org)
- These results provide experimental evidence for intranasal nerve growth factor for repair of spinal cord injury. (eurekalert.org)
- CONCLUSIONS Intranasal glucagon was highly effective in treating insulin-induced hypoglycemia in adults with type 1 diabetes. (diabetesjournals.org)
- Conclusions: Intranasal treatment with MF, AZ or SC does not cause significant changes in the general architecture of the nasal mucosa. (ent-review.com)
- Anagnostou E, Soorya L, Brian J, Dupuis A, Mankad D, Smile S, Jacob S. Intranasal oxytocin in the treatment of autism spectrum disorders: a review of literature and early safety and efficacy data in youth. (rush.edu)
- Treatment of severe hypoglycemia should be administered when possible by bystanders while awaiting emergency medical services and currently involves parenteral administration of glucagon. (diabetesjournals.org)
- The investigators hypothesize that prior administration of the vasoconstrictor will greatly reduce blood oxytocin concentrations following intranasal oxytocin treatment. (trialbulletin.com)
- and (2) DAT binding in response to intranasal VEH was lower when IN-DA application preceded VEH treatment. (frontiersin.org)
- Rhinitis Related to OMP Suppression by Intranasal Budesonide Treatment. (bioportfolio.com)
- Nerve growth factor can be delivered to the brain by intranasal administration without risk for treatment of brain diseases. (eurekalert.org)
- We investigated the effect of treatment with intranasal transforming growth factor-β1 (TGF-β1) on neurogenesis in the adult mouse SVZ following focal ischemia. (biomedcentral.com)
- Intranasal treatment of TGF-β1 shows significant improvement in neurological function and reduction of infarct volume compared with control animals. (biomedcentral.com)
- 1. A method of reducing food intake of a subject, comprising intranasal administration of a pharmaceutical composition comprising an effective amount of diltiazem to a subject in need of such treatment. (google.com)
- The intranasal form is indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression. (medscape.com)
- These results suggest that direct administration of SAL200 into the lungs could be a potential adjunct treatment against severe pneumonia caused by S. aureus. (ewha.ac.kr)
- Dr. Luigi Aloe, Cellular Biology and Neurobiology Institute, National Research Council, Italy and his team performed a study to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons. (eurekalert.org)
- Aloe L, Bianchi P, De Bellis A, Soligo M, Rocco ML. Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury. (eurekalert.org)
- Furthermore, it is anticipated that intranasal delivery can offer admittance to the central nervous system without affecting the integrity of the blood-brain barrier. (curofy.com)
- A combination of 0.1 mg/kg dexmedetomidine, ketamine 20 mg/kg and 0.4 mg/kg morphine was administered by inserting a lubricated catheter in intranasal. (journalcra.com)
- The intranasal dexmedetomidine-ketamine-morphine combinations has been successfully used for modarate sedation for 10 minutes in young dogs. (journalcra.com)
- Pre-administration of GH blunts the GH-releasing effect of examorelin, while, in contrast, fully abolishing the effect of GHRH. (wikipedia.org)
- Its effectiveness is similar to that of the intravenous preparation, although its peak effect is observed later, at 60-90 minutes after administration. (medscape.com)
- One recent study has demonstrated that intranasal fibroblast growth factor-2 (FGF-2) or heparin-binding epidermal growth factor-like growth factor (HB-EGF) increase neurogenesis in the normal adult mouse brain [ 7 ], but the effect of intranasal neurotrophic factors on neurogenesis in animals after stroke has not been investigated. (biomedcentral.com)
- The current study suggests that single administration of intranasal oxytocin is likely safe in elementary school-aged children. (springer.com)
- This study compared IV naloxone with intranasal naloxone delivered by a commercially available atomizer in healthy dogs. (cliniciansbrief.com)
- Study Design: Biopsies of the lower nasal turbinate were obtained from four groups of 8 individuals after 14 days of daily administration of a saline solution (control group) or of MF, AZ and SC. (ent-review.com)
- fentanyl OR diamorphine) AND intranasal. (bestbets.org)
- It has been demonstrated that intranasal fentanyl or diamorphine are effective alternatives to intravenous morphine among children in the ED and for relief of postoperative pain and anxiety in children undergoing ear, nose and throat (ENT) surgery. (bestbets.org)
- Intranasal supplementation of L. paracasei NCC2461 was more potent than intragastric application in limiting the allergic response and possibly linked to an increase in T regulatory cells in the lungs. (hindawi.com)
- The growing adoption of mucosal atomization devices is primarily attributed to factors such as, non-invasive nature, faster delivery of medication to the bloodstream, ease of administration, and no first-pass metabolism among others. (futuremarketinsights.com)
- Further, as emerging intranasal delivery technologies eliminate the use of needles, there is no risk of needle-stick problems. (futuremarketinsights.com)
- Intranasal administration of INP105 is through Impel's proprietary device, Precision Olfactory Delivery (POD). (in-pharmatechnologist.com)
- Intranasal administration is a convenient form of delivery that is applicable to several opioids. (dovepress.com)
- Intranasal administration is a noninvasive and valid method for delivery of neuropeptides into the brain, to bypass the BBB. (biomedcentral.com)
- In addition, numbers of BrdU- labeled cells coexpressed with the migrating neuroblast marker doublecortin (DCX) and the mature neuronal marker neuronal nuclei (NeuN) were significantly increased after intranasal delivery of TGF-β1, while only a few BrdU labeled cells co-stained with glial fibrillary acidic protein (GFAP). (biomedcentral.com)
- The clinical potential of intranasal oxytocin in psychiatry. (springer.com)
- Do not apply BACTROBAN nasal ointment concurrently with any other intranasal products [see CLINICAL PHARMACOLOGY ]. (rxlist.com)
- Impel Neuropharma announced the first participant have been dosed in a Phase I trial looking at safety and tolerability for the company's intranasal olanzapine product. (in-pharmatechnologist.com)
- Intranasal ketamine may provide an effective alternative. (luriechildrens.org)