Radiotherapy: The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.Pelvic Neoplasms: Tumors or cancer of the pelvic region.Pelvis: The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM.Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Radiotherapy Dosage: The total amount of radiation absorbed by tissues as a result of radiotherapy.Radiation Injuries: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.Adjuvants, Immunologic: Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Antidiarrheals: Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition.Rectal Neoplasms: Tumors or cancer of the RECTUM.Radiotherapy, Conformal: Radiotherapy where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators.Brachytherapy: A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.Freund's Adjuvant: An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.Radiation Dosage: The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Radiation, Ionizing: ELECTROMAGNETIC RADIATION or particle radiation (high energy ELEMENTARY PARTICLES) capable of directly or indirectly producing IONS in its passage through matter. The wavelengths of ionizing electromagnetic radiation are equal to or smaller than those of short (far) ultraviolet radiation and include gamma and X-rays.Dose-Response Relationship, Radiation: The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.Radiotherapy, Intensity-Modulated: CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Radiotherapy Planning, Computer-Assisted: Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Radiation Tolerance: The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.Radiotherapy, High-Energy: Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle.Radiation Oncology: A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.Dose Fractionation: Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Adjuvants, Pharmaceutic: Agents that aid or increase the action of the principle drug (DRUG SYNERGISM) or that affect the absorption, mechanism of action, metabolism, or excretion of the primary drug (PHARMACOKINETICS) in such a way as to enhance its effects.Radiation: Emission or propagation of acoustic waves (SOUND), ELECTROMAGNETIC ENERGY waves (such as LIGHT; RADIO WAVES; GAMMA RAYS; or X-RAYS), or a stream of subatomic particles (such as ELECTRONS; NEUTRONS; PROTONS; or ALPHA PARTICLES).Radiotherapy, Computer-Assisted: Computer systems or programs used in accurate computations for providing radiation dosage treatment to patients.Radiotherapy, Image-Guided: The use of pre-treatment imaging modalities to position the patient, delineate the target, and align the beam of radiation to achieve optimal accuracy and reduce radiation damage to surrounding non-target tissues.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Radiation ProtectionBreast Neoplasms: Tumors or cancer of the human BREAST.Radiation Monitoring: The observation, either continuously or at intervals, of the levels of radiation in a given area, generally for the purpose of assuring that they have not exceeded prescribed amounts or, in case of radiation already present in the area, assuring that the levels have returned to those meeting acceptable safety standards.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Radiation Pneumonitis: Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Neoplasms, Radiation-Induced: Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Radiosurgery: A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Radiation-Sensitizing Agents: Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Radiometry: The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by SCINTILLATION COUNTING.Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.Chemoradiotherapy: Treatment that combines chemotherapy with radiotherapy.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Radiation Injuries, Experimental: Experimentally produced harmful effects of ionizing or non-ionizing RADIATION in CHORDATA animals.Aluminum Hydroxide: A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc.Nasopharyngeal Neoplasms: Tumors or cancer of the NASOPHARYNX.Gamma Rays: Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.Particle Accelerators: Devices which accelerate electrically charged atomic or subatomic particles, such as electrons, protons or ions, to high velocities so they have high kinetic energy.Antineoplastic Agents, Hormonal: Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)Radiation-Protective Agents: Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.Radiodermatitis: A cutaneous inflammatory reaction occurring as a result of exposure to ionizing radiation.Organs at Risk: Organs which might be damaged during exposure to a toxin or to some form of therapy. It most frequently refers to healthy organs located in the radiation field during radiation therapy.Neoadjuvant Therapy: Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.Tamoxifen: One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Mastectomy, Segmental: Removal of only enough breast tissue to ensure that the margins of the resected surgical specimen are free of tumor.Lung Neoplasms: Tumors or cancer of the LUNG.Cranial Irradiation: The exposure of the head to roentgen rays or other forms of radioactivity for therapeutic or preventive purposes.Cosmic Radiation: High-energy radiation or particles from extraterrestrial space that strike the earth, its atmosphere, or spacecraft and may create secondary radiation as a result of collisions with the atmosphere or spacecraft.Mastectomy: Surgical procedure to remove one or both breasts.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Cobalt Radioisotopes: Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Mice, Inbred BALB CDacarbazine: An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Vincristine: An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)Background Radiation: Radiation from sources other than the source of interest. It is due to cosmic rays and natural radioactivity in the environment.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Vaccines: Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.Administration, Intranasal: Delivery of medications through the nasal mucosa.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.Radiobiology: Study of the scientific principles, mechanisms, and effects of the interaction of ionizing radiation with living matter. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Antineoplastic Agents, Alkylating: A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.Radiation Effects: The effects of ionizing and nonionizing radiation upon living organisms, organs and tissues, and their constituents, and upon physiologic processes. It includes the effect of irradiation on food, drugs, and chemicals.Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Organ Sparing Treatments: Techniques, procedures, and therapies carried out on diseased organs in such a way to avoid complete removal of the organ and preserve the remaining organ function.Lymphatic Irradiation: External or interstitial irradiation to treat lymphomas (e.g., Hodgkin's and non-Hodgkin's lymphomas) and lymph node metastases and also some autoimmune diseases, such as rheumatoid arthritis.Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Arthritis, Experimental: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.Xerostomia: Decreased salivary flow.Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)Palliative Care: Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Spinal NeoplasmsHeavy Ion Radiotherapy: The use of a heavy ion particle beam for radiotherapy, such as the HEAVY IONS of CARBON.Radioisotope Teletherapy: A type of high-energy radiotherapy using a beam of gamma-radiation produced by a radioisotope source encapsulated within a teletherapy unit.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.X-Rays: Penetrating electromagnetic radiation emitted when the inner orbital electrons of an atom are excited and release radiant energy. X-ray wavelengths range from 1 pm to 10 nm. Hard X-rays are the higher energy, shorter wavelength X-rays. Soft x-rays or Grenz rays are less energetic and longer in wavelength. The short wavelength end of the X-ray spectrum overlaps the GAMMA RAYS wavelength range. The distinction between gamma rays and X-rays is based on their radiation source.Mice, Inbred C57BLVaccines, Subunit: Vaccines consisting of one or more antigens that stimulate a strong immune response. They are purified from microorganisms or produced by recombinant DNA techniques, or they can be chemically synthesized peptides.Actuarial Analysis: The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.Iridium Radioisotopes: Unstable isotopes of iridium that decay or disintegrate emitting radiation. Ir atoms with atomic weights 182-190, 192, and 194-198 are radioactive iridium isotopes.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Vinblastine: Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Bleomycin: A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.Heavy Ions: Positively-charged atomic nuclei that have been stripped of their electrons. These particles have one or more units of electric charge and a mass exceeding that of the Helium-4 nucleus (alpha particle).Lomustine: An alkylating agent of value against both hematologic malignancies and solid tumors.Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Cell Line, Tumor: A cell line derived from cultured tumor cells.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Lymph Node Excision: Surgical excision of one or more lymph nodes. Its most common use is in cancer surgery. (From Dorland, 28th ed, p966)Leukemia, Radiation-Induced: Leukemia produced by exposure to IONIZING RADIATION or NON-IONIZING RADIATION.Thoracic NeoplasmsPostoperative Care: The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)Mechlorethamine: A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.Epirubicin: An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.Relative Biological Effectiveness: The ratio of radiation dosages required to produce identical change based on a formula comparing other types of radiation with that of gamma or roentgen rays.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Leucovorin: The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)Androgen Antagonists: Compounds which inhibit or antagonize the biosynthesis or actions of androgens.Mastectomy, Modified Radical: Total mastectomy with axillary node dissection, but with preservation of the pectoral muscles.SqualeneRecurrence: The return of a sign, symptom, or disease after a remission.Levamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)Vaccination: Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.Cancer Vaccines: Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced.Linear Energy Transfer: Rate of energy dissipation along the path of charged particles. In radiobiology and health physics, exposure is measured in kiloelectron volts per micrometer of tissue (keV/micrometer T).Immunity, Mucosal: Nonsusceptibility to the pathogenic effects of foreign microorganisms or antigenic substances as a result of antibody secretions of the mucous membranes. Mucosal epithelia in the gastrointestinal, respiratory, and reproductive tracts produce a form of IgA (IMMUNOGLOBULIN A, SECRETORY) that serves to protect these ports of entry into the body.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Acute Radiation Syndrome: A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Carboplatin: An organoplatinum compound that possesses antineoplastic activity.Amifostine: A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Health Physics: The science concerned with problems of radiation protection relevant to reducing or preventing radiation exposure, and the effects of ionizing radiation on humans and their environment.Osteoradionecrosis: Necrosis of bone following radiation injury.Saponins: A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.Aromatase Inhibitors: Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.Skin Neoplasms: Tumors or cancer of the SKIN.Radiopharmaceuticals: Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)Positron-Emission Tomography: An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.DeoxycytidineSoft Tissue Neoplasms: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.Colonic Neoplasms: Tumors or cancer of the COLON.Polysorbates: Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.Cholera Toxin: An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.Supratentorial Neoplasms: Primary and metastatic (secondary) tumors of the brain located above the tentorium cerebelli, a fold of dura mater separating the CEREBELLUM and BRAIN STEM from the cerebral hemispheres and DIENCEPHALON (i.e., THALAMUS and HYPOTHALAMUS and related structures). In adults, primary neoplasms tend to arise in the supratentorial compartment, whereas in children they occur more frequently in the infratentorial space. Clinical manifestations vary with the location of the lesion, but SEIZURES; APHASIA; HEMIANOPSIA; hemiparesis; and sensory deficits are relatively common features. Metastatic supratentorial neoplasms are frequently multiple at the time of presentation.Prostatectomy: Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic - removal through an incision above the pubis and through the urinary bladder; retropubic - as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.SEER Program: A cancer registry mandated under the National Cancer Act of 1971 to operate and maintain a population-based cancer reporting system, reporting periodically estimates of cancer incidence and mortality in the United States. The Surveillance, Epidemiology, and End Results (SEER) Program is a continuing project of the National Cancer Institute of the National Institutes of Health. Among its goals, in addition to assembling and reporting cancer statistics, are the monitoring of annual cancer incident trends and the promoting of studies designed to identify factors amenable to cancer control interventions. (From National Cancer Institute, NIH Publication No. 91-3074, October 1990)Oropharyngeal Neoplasms: Tumors or cancer of the OROPHARYNX.Acetylmuramyl-Alanyl-Isoglutamine: Peptidoglycan immunoadjuvant originally isolated from bacterial cell wall fragments; also acts as pyrogen and may cause arthritis; stimulates both humoral and cellular immunity.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Medical Oncology: A subspecialty of internal medicine concerned with the study of neoplasms.Radioactive Hazard Release: Uncontrolled release of radioactive material from its containment. This either threatens to, or does, cause exposure to a radioactive hazard. Such an incident may occur accidentally or deliberately.Laryngectomy: Total or partial excision of the larynx.Treatment Failure: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Vaccines, Synthetic: Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.Preoperative Care: Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Mucositis: An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).Proton Therapy: The use of an external beam of PROTONS as radiotherapy.Radiation Hybrid Mapping: A method for ordering genetic loci along CHROMOSOMES. The method involves fusing irradiated donor cells with host cells from another species. Following cell fusion, fragments of DNA from the irradiated cells become integrated into the chromosomes of the host cells. Molecular probing of DNA obtained from the fused cells is used to determine if two or more genetic loci are located within the same fragment of donor cell DNA.

*Radiation therapy

Radiation enteropathy The gastrointestinal tract can be damaged following abdominal and pelvic radiotherapy. Atrophy, fibrosis ... Radiation may be prescribed by a radiation oncologist with intent to cure ("curative") or for adjuvant therapy. It may also be ... Pelvic radiation disease includes radiation proctitis, producing bleeding, diarrhoea and urgency, and can also cause radiation ... It is the most commonly reported complication in breast radiation therapy patients who receive adjuvant axillary radiotherapy ...

*Endometrial cancer

Pelvic recurrences are treated with surgery and radiation, and abdominal recurrences are treated with radiation and, if ... Adjuvant radiotherapy is commonly used in early-stage (stage I or II) endometrial cancer. It can be delivered through vaginal ... External beam radiotherapy involves a beam of radiation aimed at the affected area from outside the body. VBT is used to treat ... However, the benefits of adjuvant radiotherapy are controversial. Though EBRT significantly reduces the rate of relapse in the ...

*Diathermy

... as an adjuvant to radiation in cancer treatment. Typically, hyperthermia would be added twice a week before radiation, as shown ... Hyperthermia has been used in oncology for more than 35 years, in addition to radiotherapy, in the management of different ... In some instances short wave diathermy may be applied to localize deep inflammatory processes, as in pelvic inflammatory ... Microwave diathermy is used in the management of superficial tumours with conventional radiotherapy and chemotherapy. ...

*Management of prostate cancer

It may be used instead of surgery or after surgery in early stage prostate cancer (adjuvant radiotherapy). Radiation treatments ... Although pelvic floor muscle training has been prescribed to improve urinary continence, the evidence for efficacy in men after ... Radiotherapy uses ionizing radiation to kill prostate cancer cells. When absorbed in tissue, ionizing radiation such as gamma ... In the event of positive margins or locally advanced disease found on pathology, adjuvant radiation therapy may offer improved ...

*Radiation therapy

Radiation enteropathy. The gastrointestinal tract can be damaged following abdominal and pelvic radiotherapy.[26] Atrophy, ... Radiation may be prescribed by a radiation oncologist with intent to cure ("curative") or for adjuvant therapy. It may also be ... Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is therapy using ionizing radiation, generally as part of ... It is the most commonly reported complication in breast radiation therapy patients who receive adjuvant axillary radiotherapy ...

*Cervical cancer

Radiation therapy is given as external beam radiotherapy to the pelvis and brachytherapy (internal radiation). Women treated ... "Curative pelvic exenteration for recurrent cervical carcinoma in the era of concurrent chemotherapy and radiation therapy. A ... may be treated with radiation therapy and cisplatin-based chemotherapy, hysterectomy (which then usually requires adjuvant ... Bleeding after douching or after a pelvic exam is a common symptom of cervical cancer. Infection with some types of HPV is the ...

*Index of oncology articles

UV radiation - UVA radiation - UVB radiation - uvula vaccine adjuvant - vaccine therapy - vaccinia CEA vaccine - valacyclovir ... pelvic exenteration - pelvic lymphadenectomy - pemetrexed disodium - penclomedine - penicillamine - pentetic acid calcium - ... radiotherapy - raloxifene - raltitrexed - randomized clinical trial - ranpirnase - rapamycin - rapid hormone cycling - rapid- ... radiation fibrosis - radiation oncologist - radiation physicist - radiation surgery - radiation therapist - radiation therapy ...

*Renal cell carcinoma

Chemotherapy and radiotherapy are not as successful in the case of RCC. RCC is resistant in most cases but there is about a 4-5 ... Adjuvant therapy, which refers to therapy given after a primary surgery, has not been found to be beneficial in renal cell ... It will frequently have an irregular or lobulated margin and may be seen as a lump on the lower pelvic or abdomen region. ... as well as resistance to radiation and chemotherapy are important. The main diagnostic tools for detecting renal cell carcinoma ...

*Cancer

Medical use of ionizing radiation is a small but growing source of radiation-induced cancers. Ionizing radiation may be used to ... "Radiotherapy". Patient UK. Archived from the original on 9 July 2017. Last Checked: 23 December 2015 Hill R, Healy B, Holloway ... Bagri A, Kouros-Mehr H, Leong KG, Plowman GD (March 2010). "Use of anti-VEGF adjuvant therapy in cancer: challenges and ... Surgery is generally safe, but pelvic surgeries during the first trimester may cause miscarriage. Some treatments, especially ...

*Cancer

Radiation. Radiation therapy involves the use of ionizing radiation in an attempt to either cure or improve symptoms. It works ... Bagri A, Kouros-Mehr H, Leong KG, Plowman GD (March 2010). "Use of anti-VEGF adjuvant therapy in cancer: challenges and ... Surgery is generally safe, but pelvic surgeries during the first trimester may cause miscarriage. Some treatments, especially ... is a growing specialty in wealthy countries and the major forms of human treatment such as surgery and radiotherapy may be ...

*Cancer

Radiation. Main article: Radiation-induced cancer. Radiation exposure such as ultraviolet radiation and radioactive material is ... Bagri A, Kouros-Mehr H, Leong KG, Plowman GD (March 2010). "Use of anti-VEGF adjuvant therapy in cancer: challenges and ... Surgery is generally safe, but pelvic surgeries during the first trimester may cause miscarriage. Some treatments, especially ... is a growing specialty in wealthy countries and the major forms of human treatment such as surgery and radiotherapy may be ...

*Kidney cancer

Surgery, radiation therapy, chemotherapy, immunotherapy, targeted therapy[1][2][3]. Prognosis. Five-year survival ~75% (US 2015 ... Surgery is the most common treatment as kidney cancer does not often respond to chemotherapy and radiotherapy. Surgical ... Cancers of the Kidney and Renal Pelvic". In Ries, LAG; Young, JL; Keel, GE; Eisner, MP; Horner, M-J (eds.). SEER Survival ... adjuvant therapy, helps to improve survival in kidney cancer. If the cancer cannot be treated with surgery other techniques ...

*Surgery

Postoperative therapy may include adjuvant treatment such as chemotherapy, radiation therapy, or administration of medication ...
Overall survival of pelvic cancer patients depends on control of systemic disease. If local radiation therapy depletes bone marrow function to such an extent that systemic therapies must be withheld, chances of metastatic failure increase significantly. This may be more significant for this group of patients because approximately one third of adult bone marrow is located in the pelvic region. Strategies to minimize toxicities would benefit a range of pelvic cancer patients including gynecologic, anal, rectal, and prostate. New chemoradiation combinations improve outcomes for these disease sites, but come at the cost of higher levels of toxicity. As many as 40% of cervical cancer patients miss at least one chemotherapy cycle due to hematologic toxicity and 36% of anal cancer patients experience grade 3 or 4 hematologic toxicity when undergoing chemoradiation therapy. A clinical trial of concurrent ...
Abstract  As a large amount of blood loss is sometimes encountered in limb salvage procedures for pelvic tumours, it is essential to identify risk factors predicting the possibility of extensive haemorrhage. We retrospectively reviewed 137 patients who underwent pelvic tumour resections. Patients with an estimated blood loss greater than 3,000 ml were classified as having a large amount of blood loss. Sixty-one (44.53%) patients had blood loss greater than 3,000 ml. Tumours involving the acetabulum or sacrum, tumour volume greater than 400 cm3, aorta occlusion, resection method, reconstruction and operative time were all associated with a large amount of blood loss. Pelvic tumours involving the acetabulum or sacrum (odds ratio: 4.837), tumour volume greater than 400 cm3 (odds ratio: 3.005) and planned operation time of more than 200 min (odds ratio: 3.784) independently predicted a large amount of blood loss. Pelvic tumours with these ...
Vaginal stenosis can occur as a result of treatment for pelvic malignancies. Women receiving pelvic radiation therapy using a vaginal dilator 5-7 times
Radiation proctitis (and the related radiation colitis) is inflammation and damage to the lower parts of the colon after exposure to x-rays or other ionizing radiation as a part of radiation therapy. Radiation proctitis most commonly occurs after treatment for cancers such as cervical cancer, prostate cancer, and colon cancer. Radiation proctitis involves the lower intestine, primarily the sigmoid colon and the rectum and is part of the conditions known as pelvic radiation disease and radiation enteropathy. Radiation proctitis can occur at two times after treatment: Acute radiation proctitis - symptoms occur in the first few weeks after therapy. These symptoms include diarrhea and the urgent need to defecate, often with pain while doing so (tenesmus). Acute radiation proctitis usually resolves without ...
The pelvic cavity is a body cavity that is bounded by the bones of the pelvis. Its oblique roof is the pelvic inlet (the superior opening of the pelvis). Its lower boundary is the pelvic floor. The pelvic cavity primarily contains reproductive organs, the urinary bladder, the pelvic colon, and the rectum. The rectum is placed at the back of the pelvis, in the curve of the sacrum and coccyx; the bladder is in front, behind the pubic symphysis. In the female, the uterus and vagina occupy the interval between these viscera. The pelvic cavity also contains major arteries, veins, muscles, and nerves. These structures coexist in a crowded space, and disorders of one pelvic component may impact upon another; for example, constipation may overload the rectum and compress the urinary bladder, or childbirth might damage the pudendal nerves and later lead to anal weakness. The pelvis has an ...
Results Ten patients (8 male, median age 59 years) underwent Endo-Sponge therapy. Seven were treated for anastomotic leaks following low anterior resection. Two patients had symptomatic low pelvic cavities following ileal pouch excision and 1 was treated for a pelvic cavity following a perforated low Hartmanns stump. Seven patients were treated within 17 days (0-17 days) of diagnosis of pelvic sepsis. The remaining 3 patients were treated for chronic low pelvic cavities at intervals ranging from 5 months following index surgery. Median duration of treatment was 28.5 days (8-40 days) with a median number of sponge changes of 7 (2-11 changes). One patient developed a transient inflammatory response and pneumoperitoneum which settled with antibiotic therapy but there were no other complications. All patients had clinical resolution of pelvic sepsis and four patients had definitive cavity closure.. ...
Aggressive angiomyxoma is an uncommon soft tissue tumor which preferentially involves pelvic and vulvoperineal regions of young adult females. The typical characteristics include gelatinous appearance
Whatever the exact definition, practically BTcP is a transient exacerbation of pain that occurs despite well-controlled background pain, by giving around the clock opioid administration able to provide at least mild analgesia [24]. It is distinguishable from background pain by being transient or episodic and breaking through the stable, controlled chronic background pain. About the pain features, it can manifest itself as somatic, visceral, neuropathic, or mixed pain, and baseline pain may have the same classification or a different classification. According to this information, the phenomenon of BTcP should be expected in about 70 % of patients, despite receiving effective regular opioids in doses of ≥60 mg/day of oral morphine equivalents, able to provide acceptable background analgesia with a mild pain intensity for most hours of the day [31]. See Sect. 1 for BTcP management. References 1. Sams T (ed) (2006) ABCs of pain relief and treatment: advances, breakthroughs, and choices. ...
CONCLUSIONS: Angiomyxoma is a rare, benign and locally aggressive tumor, which can infiltrate locally and present unusually as perineal hernia. Due to its rarity and lack of specific diagnostic requirements, its difficult to diagnose preoperatively KEY WORDS: Angiomyxoma, Obturator hernia, Pelvic mass. PMID: 31723050 [PubMed - in process]...
Oral mucosal melanoma is a rare disease with a relatively poor prognosis. Carbon ion radiotherapy has been shown to be effective against radiotherapy-resistant tumors owing to its excellent dose concentration and high biological effect. Our patient was a 66-year-old Japanese man with oral mucosal melanoma of his right maxillary gingiva (T4aN0M0). He received carbon ion radiotherapy at 57.6 Gy (relative biological effectiveness) in 16 fractions for 4 weeks. Concomitant chemotherapy (dacarbazine + nimustine + vincristine) was administered at the same time as carbon ion radiotherapy initiation. Two courses of adjuvant chemotherapy were given after carbon ion radiotherapy. Although he experienced grade 2 acute oral mucositis, his symptoms improved within a few weeks of undergoing carbon ion radiotherapy. He was alive at the time of reporting, 35 months after treatment, without ...
RATIONALE: Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether chemotherapy and radiation therapy are more effective when given with or without additional chemotherapy in treating cervical cancer.. PURPOSE: This randomized phase III trial is studying chemotherapy and pelvic radiation therapy to see how well they work when given with or without additional chemotherapy in treating patients with high-risk early-stage cervical cancer after radical hysterectomy. ...
The pelvic cavity contains the urinary bladder, the colon, the rectum and reproductive organs. Female reproductive organs in the pelvic cavity include the uterus, ovaries and fallopian tubes. In men,...
In a randomized noninferiority trial (TARGIT-A) reported in The Lancet, Jayant S. Vaidya, PhD, and Michael Baum, MD, of University College London, and colleagues compared risk-adapted radiotherapy using single-dose targeted intraoperative radiotherapy vs fractionated external-beam radiotherapy in women with breast cancer. Targeted intraoperative radiotherapy met the noninferiority margin for 5-year local recurrence among all patients and when given concurrently with lumpectomy but not when delayed until after lumpectomy (postpathology). Breast cancer mortality did not differ significantly between the two groups, but targeted intraoperative radiotherapy was associated with reduced non-breast cancer mortality.. Study Details. In this open-label, randomized trial, 3,451 women aged ≥ 45 years with invasive ductal carcinoma were randomly assigned to receive single-dose targeted intraoperative radiotherapy (n = ...
Primary treatment of pelvic cancers such as adenocarcinoma of the rectum, prostate cancer or gynaecological tumors often includes radiotherapy. The locoregional recurrence rate in women treated with radiochemotherapy for cervical cancer is 35% over all stages [8] and 3% to 15% in patients treated for rectal adenocarcinoma [61]. Patients are frequently not considered eligible for salvage surgery especially in the case of lateral pelvic wall involvement or tumor abutment to the iliac vessels [62].. Dewas et al. presented a retrospective study of 16 patients reirradiated with Cyberknife for lateral pelvic recurrences [63]. Patients were treated for recurrences of primary anal canal cancer (6 patients), rectal cancer (4 patients), uterine cervix cancer (4 patients), endometrial cancer (1 patient) and bladder carcinoma (1 patient). Patients had been treated before with a median RT dose of 45 Gy (range, 20 Gy - 96 Gy), median interval between ...
Aggressive angiomyxoma (AAM), a rare soft tissue benign neoplasm mesenchymal in origin, predominantly occurs in the female pelvic peritoneum and perineum region during reproductive age. It is slow growing, locally infiltrative, and has a high risk of local recurrence and the neoplastic character of blood vessels. We here present two unusual cases of angiomyxoma presenting as huge abdominal lump. Magnetic Reasonance Imaging (MRI) & Computed Tomography (CT) depicted findings of AAM which were confirmed on histopathologic evaluation.. ...
Regarding diagnosis with AAM, the characteristic MRI findings of AAM include the following: On T1-weighted MRI, it has low signal intensity. That is, it is of the same signal intensity as the skeletal muscle. On T2-weighted MRI, it has high signal intensity. These appearances likely relate to the loose myxoid matrix and high water content of angiomyxoma [11]. The CT findings demonstrated that the tumor, later identified as AAM, had a well-defined margin and an attenuation less than that of a muscle [11]. On ultrasonography, AAM appears as a hypoechoic or cystic mass [12]. In our case, the liver mass showed high signal intensity on T2-weighted MRI, as an attenuated mass on CT, and as a hypoechoic cystic region on ultrasound (Fig. 1). In our case, CT and FDG-PET unable to detect any mass in other regions including the pelvi-perineal region. Therefore, the AAM was concluded as of liver origin.. Immunohistochemically, AAM has been found to be positive for vimentin, desmin, CD 34, ER, PgR, and ...
Looking for online definition of abdominopelvic splanchnic nerves in the Medical Dictionary? abdominopelvic splanchnic nerves explanation free. What is abdominopelvic splanchnic nerves? Meaning of abdominopelvic splanchnic nerves medical term. What does abdominopelvic splanchnic nerves mean?
Ojha, Rohit P. Hematologic malignancies following external beam radiation therapy for localized prostate cancer. Doctor of Public Health (Epidemiology), December 2010, 88 pp., 6 tables, 2 illustrations, references, 96 titles. The incidence of hematologic malignancies following external beam radiation therapy (EBRT) among prostate cancer patients has received limited attention despite evidence that radiation has a role in leukemogenesis and myelomagenesis. Therefore, we investigated the effect of external beam radiation therapy on acute myeloid leukemia and myeloma incidence among prostate cancer patients. We utilized the Surveillance, Epidemiology, and End Results database to identify a cohort of men (n=168,612) with newly diagnosed prostate adenocarcinoma between January 1988 and December 2003. Cox proportional hazard regression was used to estimate the hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) of ...
TY - JOUR. T1 - A case of radiation retinopathy after carbon ion radiotherapy for adenoid cystic carci - I noma in the sphenoid sinus. AU - Watanabe, Koichiro. AU - Toshima, Shinji. AU - Shibata, Kiyo. AU - Hosokawa, Mio. AU - Doi, Shinichiro. AU - Noda, Hiroshi. AU - Terada, Yoshiko. AU - Hara, Kazuyuki. PY - 2016/3/1. Y1 - 2016/3/1. N2 - Purpose: To report a case of radiation retinopathy after carbon ion radiotherapy for adenoid cystic carcinoma in the sphenoid sinus. Case: A 26-year-old female was referred to us for impaired visual acuity in the right eye. She had received carbon ion radiotherapy for adenoid cystic carcinoma in the right sphenoid sinus extending to the right cavernous sinus 19 months before. The dosis of radiation totaled 57.6 GyE. Findings: Corrected visual acuity was 0.8 right and 1.2 left. The right fundus showed a few retinal hemorrhages and cotton-wool spots. Fluorescein angiography ...
Radiation injury to normal tissues was first reported by Roentgen and Pierre Curie as delayed skin healing after exposure to radium.1 Over the next 20 years, the suppressive effects of radiation on tumor growth were discovered, laying the foundation for widely successful therapy for cancer.2. Despite these successes, radiation is associated with acute and long-term toxicity to normal tissue. During the typical 5- to 6-week treatment course of radiotherapy for pelvic cancer, ≈80% of patients will develop gastrointestinal complications.3 Long-term toxicity of pelvic radiotherapy is divided into 2 types of disorders: those that are life-threatening and, more commonly, those manifested with chronic changes in bowel behavior. The life-threatening conditions, such as sepsis, stenosis, fistulation, intestinal failure, perforation, transfusion-dependent bleeding, and secondary cancer development, ...
The present study presents a case of peritoneal malignant mesothelioma (PMM) following radiation therapy for cervical cancer. A 34‑year‑old Japanese woman, without asbestos exposure, was referred to the Department of Gynecologic Oncology, Saitama Medical University International Medical Center due to a cervical mass, and was diagnosed with cervical squamous cell carcinoma (SCC). The serum levels of tumor markers, including SCC antigen and cancer antigen 125 (CA125) were 229.0 ng/ml and 54.4 U/ml, respectively. The patient underwent concurrent chemoradiotherapy (CCRT), and a complete response was achieved. After 54 months, ascites was found at the rectouterine pouch, but peritoneal cytology suggested reactive mesothelial cell. After 62 months of CCRT, magnetic resonance imaging revealed masses in both the salpinges. The serum levels of SCC and CA125 were 0.9 ng/ml and 506.1 U/ml, respectively. Following this, left salpingectomy and peritoneal biopsy were performed ...
TY - JOUR. T1 - Patterns of relapse following radiotherapy for differentiated thyroid cancer. T2 - Implication for target volume delineation. AU - Azrif, Muhammad. AU - Slevin, Nicholas J.. AU - Sykes, Andrew J.. AU - Swindell, Ric. AU - Yap, Beng K.. PY - 2008/10. Y1 - 2008/10. N2 - Introduction: Post-operative residual disease in differentiated thyroid cancer is an indication for external beam radiotherapy (EBRT) especially if there is poor radioiodine uptake by the residual disease. There are no standardized guidelines or consensus in target delineation for radiotherapy in thyroid cancer. Aims: To determine the pattern of recurrence in patients with well differentiated thyroid cancer who received adjuvant or definitive radiotherapy as well as radioiodine ablation following surgery or biopsy with a view to better defining future target volume delineation for radiotherapy. Materials and ...
Gynecology: Endometriosis of the pelvic cavity | Diagnostic laparoscopy and conservative treatment. Treatment in Geneva, Switzerland ✈ Find the best medical programs at BookingHealth - ✔Compare the prices ✔Online booking.
Endometriosis of the pelvic cavity | Diagnostic laparoscopy and conservative treatment. Gynecology: Treatment in Hamburg, Germany ✈. Prices on BookingHealth.com - booking treatment online!
article{62467ba8-5393-440f-b737-11cd1101dfa8, abstract = {Background: Abdominal surgery for cancer carries a high risk of venous thromboembolism, but the optimal duration of postoperative thromboprophylaxis is unknown. Methods: We conducted a double-blind, multicenter trial in which patients undergoing planned curative open surgery for abdominal or pelvic cancer received enoxaparin (40 mg subcutaneously) daily for 6 to 10 days and were then randomly assigned to receive either enoxaparin or placebo for another 21 days. Bilateral venography was performed between days 25 and 31, or sooner if symptoms of venous thromboembolism occurred. The primary end point with respect to efficacy was the incidence of venous thromboembolism between days 25 and 31. The primary safety end point was bleeding during the three-week period after randomization. The patients were followed for three months. Results: The intention-to-treat analysis of efficacy included 332 patients. The rates of venous thromboembolism ...
The Scientific basis of modern radiotherapy: an international symposium to mark the achievements of John Francis Fowler ... held in the Fowler-Scott Library of the Cancer Research Campaign Gray Laboratory, Northwood, Middlesex, 30th June-2nd July 1988 ...
The Scientific basis of modern radiotherapy: an international symposium to mark the achievements of John Francis Fowler ... held in the Fowler-Scott Library of the Cancer Research Campaign Gray Laboratory, Northwood, Middlesex, 30th June-2nd July 1988 ...
Over the course of its 100-year history, the centre for radiation oncology and tumour research has become one of the worlds largest and most modern facilities for radiooncology and radiotherapy. Radiation oncology is one of the three main pillars of cancer treatment together with surgery and chemotherapy.. More than 3,500 people are treated at the centre every year by specialist doctors and nurses, on both an inpatient and outpatient basis. All modern radiotherapy procedures for the treatment of tumours are offered at Heidelberg University Hospital. The department currently has eight radiotherapy systems including two tomotherapy units (which surround the patient like a CT scan), plus a facility for intraoperative radiotherapy in the departments of surgery and gynaecology. In addition, we offer the complete spectrum of brachytherapy, in which a localised radiation source is positioned near ...
External Beam Radiation Therapy (EBRT) delivers radiation from outside the body with a machine called a linear accelerator. External Beam Radiation Therapy can be used as the only modality of treatment or in combination with chemotherapy, immunotherapy, or hormonal therapy, and can also be used prior to or following surgery, depending on the diagnosis and stage of disease. Although there can be side effects that develop gradually, the treatment itself is painless and relatively rapid.
Today women ask us not only to be cured but also the preservation of their body; this is one of our most important endpoints in modern radiotherapy treatments. The radiotherapy-induced skin toxicity remains a major clinical problem that affects many patients with breast cancer undergoing adjuvant radiotherapy [18]. Anyway there is a growing emphasis on prevention and treatment of side effects induced by radiation therapy; this attention has derived many studies dealing about the treatments and substances that can protect healthy organs from radiation therapy side effects.. Surely the breast volume has a great impact on the incidence and the level of skin toxicity, but also the breast volume receiving dose-points equal or greater than 107% of the one prescribed has an impact in the arising of side effects. Thats because many studies aimed to find appropriate prevention methods for damages are ...
Cardiovascular diseases following radiotherapy are major secondary late effects raising questions among the scientific community, especially regarding the dose-effect relationship and confounding risk factors (chemotherapy, cholesterolemia, age at treatment, blood pressure,…). Post-radiation coronary diseases are one of the main causes of cardiac morbidity. Some approximations are made when coronary doses due to radiotherapy are estimated, especially regarding the morphology. For retrospective studies with old medical records, only radiographs are usually available with sometimes some contours made with a simulator. For recent medical records, CT scans displaying the anatomy in 3D are used for radiotherapy simulation but do not allow the coronary artery visualization due to low resolution and contrast. Currently, coronary doses are barely assessed in clinical practice, and when it is done, anatomical prior knowledge is generally used. This ...
Bckground: Adjuvant radiation therapy is commonly administered following breast-conserving surgery for breast cancer patients. Hypofractionated radiotherapy can significantly reduce the waiting time for radiotherapy, working load on machines, patient visits to radiotherapy departments and medical costs. Material/Methods: Fifty-two patients with operable breast cancer (pT1-3pN0M0) who underwent breast conservation surgery in Tehran Cancer Institute during January 2011 to January 2012, were randomly assigned to undergo radiotherapy in two arms (hypofractionated radiotherapy arm with 30 patients, dose 42.5 Gy in 16 fractions; and conventional radiotherapy arm with 22 patients, dose 50 Gy in 25 fractions). W compared these two groups in terms of overall survival, locoregional control, late skin complications and cosmetic results. Results: At a median follow-up ...
Department of Otolaryngology and oral cancer can often cervical lymph node metastasis, the sites mostly in the deep cervical, middle and nerve chain lymph nodes. If there is transfer of supraclavicular lymph nodes, the first consideration should be from the chest, abdominal and pelvic malignancies. It should also pay attention to and craniopharyngioma, chordoma, and sphenoid sinus cyst phase identification. ...
Lumbosacral plexopathy can result when radiation, used in the treatment of various neoplasms, is directed toward management of abdominal and pelvic malignancies. Anatomically, the lumbosacral plexus consists of lumbar (L1-L4) and sacral (L5-S5) portions, which are connected by the lumbosacral trunk (L4-L5).
In patients who had undergone surgery for brain metastases, the rate of recurrence at the resected site was similar between patients who received adjuvant whole-brain radiotherapy vs those who underwent adjuvant localized radiotherapy, according to a retrospective study by Hsieh et al in the journal Neurosurgery. However, localized radiotherapy was associated with a higher incidence of distant metastases.. Surgery followed by adjuvant whole-brain radiotherapy is a well-established treatment for brain metastases, particularly in patients who have a limited number of brain metastases. Yet discussions continue as to whether these patients require whole-brain radiotherapy or can be treated with localized radiotherapy. Localized radiotherapy is associated with fewer side effects compared with ...
TY - JOUR. T1 - Bcl-2 and bax expression and prostate cancer outcome in men treated with radiotherapy in Radiation Therapy Oncology Group protocol 86-10. AU - Khor, Li Yan. AU - DeSilvio, Michelle. AU - Li, Rile. AU - McDonnell, Timothy J.. AU - Hammond, M. Elizabeth H. AU - Sause, William T.. AU - Pilepich, Miljenko V.. AU - Okunieff, Paul. AU - Sandler, Howard M.. AU - Pollack, Alan. PY - 2006/9/1. Y1 - 2006/9/1. N2 - Purpose: Bcl-2 and bax are proteins with opposing roles in apoptosis regulation; yet abnormal expression of either has been associated with failure after radiotherapy (RT). In this study we examined bcl-2 and bax expression as predictive markers in men treated with radiotherapy ± androgen deprivation on Radiation Therapy Oncology Group (RTOG) protocol 86-10. Experimental Design: Suitable archival diagnostic tissue was obtained from 119 (26%) patients for bcl-2 analysis and 104 (23%) patients for bax analysis. ...
Radiotherapy is the mainstay of treatment after surgery for high-grade gliomas and is usually well tolerated. Radiation toxicity in the brain is usually classified according to the timing of side effects in relation to treatment, as either acute (during radiotherapy), early delayed (within 12 weeks of radiotherapy) or late delayed (months to years after radiotherapy). We report two cases of young women who developed severe acute demyelination within 4 months of radiotherapy for glioma, one of whom had a previous history of transverse myelitis. Both improved with corticosteroids and remain in tumour remission. These cases emphasise the importance of careful discussion with patients before starting radiotherapy if there is a previous history of central nervous system demyelination or multiple white matter lesions on MRI. ...
Types of radiation therapy include external beam radiation therapy, particle therapy, brachytherapy, radioisotope therapy and more. See below for local oncologists and other specialists in Ames that give access to radiation therapy as well as advice and content on radiation oncology and cancer treatment.
Types of radiation therapy include external beam radiation therapy, particle therapy, brachytherapy, radioisotope therapy and more. See below for local oncologists and other specialists in Essex Junction that give access to radiation therapy as well as advice and content on radiation oncology and cancer treatment.
It is well known that the electronic nose can be used to identify differences between human health and disease for a range of disorders. We present a pilot study to investigate if the electronic nose and a newer technology, FAIMS (Field Asymmetric Ion Mobility Spectrometry), can be used to identify and help inform the treatment pathway for patients receiving pelvic radiotherapy, which frequently causes gastrointestinal side-effects, severe in some. From a larger group, 23 radiotherapy patients were selected where half had the highest levels of toxicity and the others the lowest. Stool samples were obtained before and four weeks after radiotherapy and the volatiles and gases emitted analysed by both methods; these chemicals are products of fermentation caused by gut microflora. Principal component analysis of the electronic nose data and wavelet transform followed by Fisher discriminant analysis of FAIMS data indicated that it was possible to ...
This volume collects a series of lectures presented at the tenth ESI School held at Archamps (FR) in November 2007 and dedicated to radiotherapy and brachytherapy. The lectures focus on the multiple facets of radiotherapy in general, including external radiotherapy (often called teletherapy) as well as internal radiotherapy (called brachytherapy). Radiotherapy strategy and dose management as well as the decisive role of digital imaging in the associated clinical practice are developed in several articles. Grouped under the discipline of Conformal Radiotherapy (CRT), numerous modern techniques, from Multi-Leaf Collimators (MLC) to Intensity Modulated RadioTherapy (IMRT), are explained in detail. The importance of treatment planning based upon patient data from digital imaging (Computed Tomography) is also underlined. Finally, despite the quasi- totality of patients being presently treated ...
TY - JOUR. T1 - Postoperative External Beam Radiotherapy for Differentiated Thyroid Cancer. T2 - Outcomes and Morbidity With Conformal Treatment. AU - Schwartz, David L.. AU - Lobo, Mark J.. AU - Ang, K. Kian. AU - Morrison, William H.. AU - Rosenthal, David I.. AU - Ahamad, Anesa. AU - Evans, Douglas B.. AU - Clayman, Gary. AU - Sherman, Steven I.. AU - Garden, Adam S.. PY - 2009/7/15. Y1 - 2009/7/15. N2 - Purpose: To review institutional outcomes for patients treated for differentiated thyroid cancer with postoperative conformal external beam radiotherapy (EBRT). Methods and Materials: This is a single-institution retrospective review of 131 consecutive patients with differentiated thyroid cancer who underwent EBRT between January 1996 and December 2005. Histologic diagnoses included 104 papillary, 21 follicular, and six mixed papillary-follicular types. American Joint Committee on Cancer stage distribution was Stage III in 2 patients, Stage IVa-IVc in 128, and not ...
Radiotherapy is a type of treatment that uses pulses of radiation to destroy cancer cells. There are a number of ways it can be used to treat people with lung cancer.. An intensive course of radiotherapy, known as radical radiotherapy, can be used to try to cure non-small-cell lung cancer if the person isnt healthy enough for surgery. For very small tumours, a special type of radiotherapy called stereotactic radiotherapy may be used instead of surgery.. Radiotherapy can also be used to control the symptoms and slow the spread of cancer when a cure isnt possible (this is known as palliative radiotherapy).. A type of radiotherapy known as prophylactic cranial irradiation (PCI) is also sometimes used during the treatment of small-cell lung cancer. PCI involves treating the whole brain with a low dose of radiation. Its used as a ...
Polls show that the public do not recognise radiotherapy as a modern form of cancer therapy, and many would describe it as frightening. Yet radiotherapy is one of the most effective cancer treatments available, and a staggering array of new developments should allow radiotherapy to become increasingly personalised to individual cancer patients.. Major advances, such as Intensity Modulated Radiotherapy (IMRT), proton therapy, Cyberknife technology and research combining radiotherapy with MRI imaging, viral therapy, and chemotherapy, promise to revolutionise radiotherapy in the future.. Leading experts in radiotherapy came to the SMC discuss things such as:. ...
Results Out of the 12 patients in the study, 6 did not receive radiotherapy either because they elected for subsequent radical surgery (3 patients) or were unfit for further treatment and underwent close follow-up (3 patients).. In the radiotherapy group, 2 patients had pre-op Long-Course Chemo-radiotherapy (LCCRT) with a good partial response, 2 were included in the national TEM and Radiotherapy in Early Rectal cancer (TREC) trial and had pre-op Short Course radiotherapy (SCRT) and 2 had adjuvant LCCRT + Papillon contact radiotherapy following TEM.. Median follow-up was 20 months. Patients not undergoing radial surgery had 3 monthly MR and sigmoidoscopy for 1 year and 6 monthly MR and sigmoidoscopy for a further 2 years.. In the no-radiotherapy group, 1 of the 3 patients who underwent subsequent radical surgery had involved mesorectal lymph nodes and 1 of ...
There is a wide variation of risk estimates for second cancer in the literature. Lifetime breast cancer induction risk for a breast exposed to 1 Gy is approximately 5% if irradiated at the age of , 35, , 3% at the age of 35-45, and much less at an older age [10]. For a phantom case study [21] the incremental risk of secondary cancer was calculated for the tangential whole breast technique with wedge compensators based on National Council on Radiation Protection and Measurements (NCRP) report 116 [20] as 0.34% which is likely to be undetectable compared to the observed frequency of contralateral breast cancer of about 7% at 10 years and 10% at 15 years [28, 29]. The causes of contralateral breast cancer amongst breast cancer patients given radiotherapy are less obvious. A large study by Kirova et al. did not show an increased risk of contralateral breast cancer for those receiving radiotherapy [30]. Obedian reported no significant difference in the occurrence ...
January 25, 2013 - The study finds that in several countries in Western Europe there are too few radiotherapy machines to ensure that cancer patients in need of radiotherapy receive treatment. For instance, in Italy around 16 percent of need is unmet, in Portugal 19 percent, Austria 20 percent and the UK and Germany 21 percent. However, the authors caution that these apparent gaps in treatment supply may be compensated by more efficient organization of radiotherapy provision.. Led by Eduardo Rosenblatt from the International Atomic Energy Agency in Austria, the researchers analyzed data from the Directory of Radiotherapy Centers (DIRAC) database, a global registry of radiotherapy facilities, to compare the need for radiotherapy equipment with existing supply based on the number of inhabitants and cancer incidence in 33 European countries.. Availability of radiotherapy services varies widely ...
PURPOSE: To assess the effect of more extensive radiotherapy and of adjuvant combination chemotherapy on long-term outcome of early-stage Hodgkins disease. METHODS: In a collaborative worldwide systematic overview, individual patient data were centrally reviewed on 1,974 patients in eight randomized trials of more versus less extensive radiotherapy and on 1,688 patients in 13 trials of radiotherapy plus chemotherapy versus radiotherapy alone. Crude mortality data on 226 patients in two other trials of chemotherapy were also reviewed. RESULTS: More extensive radiotherapy reduced the risk of treatment failure (resistant or recurrent disease) at 10 years by more than one third (31.3% v 43.4% failures; P | .00001), but there was no apparent improvement in overall 10-year survival (77.1 % v 77.0% alive). The addition of chemotherapy to radiotherapy halved the 10-year risk of ...
Post-operative radiotherapy is internationally accepted as standard practice in the management of high-risk endometrial cancer1. Whilst it has no proven impact on overall survival it significantly increases local control.. Conventional radiotherapy techniques (3-dimensional) utilise a 3 or 4 field beam arrangement to target the pelvis in order to treat those areas at risk of recurrence: the vagina, the parametrium and the pelvic lymph nodes. However, when using such a technique it is not possible to avoid irradiating sensitive normal tissues such as the bowel and bladder.. Toxicity data from international randomised control trials in endometrial cancer report significantly more haematological, gastrointestinal, genitourinary and cutaneous toxicites (all grades) in those who received pelvic irradiation compared to those who did not2,3. These trials delivered radiotherapy using 2 or 3-dimensional techniques.. ...
[email protected] College Park, Maryland -- April 3, 2009 -- Proton therapy has been hailed as a revolutionary cancer treatment, with higher cure rates and fewer side effects than traditional X-ray photon radiotherapy. Proton therapy is the modality of choice for treating certain small tumors of the eye, head, head or neck. It is also safer -- especially for young children -- because it exposes less of the tissue surrounding a tumor to the dosage, proton therapy lowers the risk of secondary cancers later in life.. What does the scientific evidence show about proton therapy? With the rapid proliferation of proton facilities in the United States, what will current and future practitioners of proton radiotherapy need to know? Now a panel of researchers, clinicians, and public health experts will debate the promise and perils of proton radiotherapy -- a 70-year-old idea that bridges medicine and particle physics. Spearheaded by the AAPM Science Council and ...
Between 1991 and 1996, 268 patients were entered onto the study. Two hundred forty-three patients were assessable (127 RT + CT patients and 116 RT patients). Progression-free and overall survival are significantly improved in the patients receiving CT. The hazard ratios for progression-free survival and overall survival in the RT only arm versus the RT + CT arm are 2.01 (P =.003) and 1.96 (P =. 007), respectively. The projected progression-free survivals at 4 years is 63% with RT and 80% with RT + CT. The projected overall survival rate at 4 years is 71% with RT and 81% with RT + CT. Grades 3 and 4 hematologic and gastrointestinal toxicity were more frequent in the RT + CT group. Conclusion: ...
TY - JOUR. T1 - Radical radiotherapy with or without chemotherapy for hypopharyngeal carcinoma. AU - Yorozu, Atsunori. AU - Toya, Kazuhito. AU - Fukada, Junichi. AU - Dokiya, Takushi. PY - 2004/6. Y1 - 2004/6. N2 - We took a routine conservative approach for hypopharyngeal carcinoma. This retrospective study analyzes the outcome of treatment with this policy. Between 1993 and 2002, 36 patients with hypopharyngeal carcinoma received radiotherapy with or without chemotherapy at our institution. Doses ranged from 60 Gy to 72 Gy given to the involved fields. Fourteen patients received CDDP and 5FU, either inductive or concurrent with radiotherapy. The overall five-year survival was 38% and the two-year local control rate was 69%. The local control rate was dependent on the size of primary tumor. Two-year local control rates were 60% with radiotherapy alone and 88% with chemoradiotherapy. Neck dissections combined with ...
Purpose: Radiotherapy has reduced local recurrence of rectal cancers, but the result is not satisfactory. Further biologic factors are needed to identify patients for more effective radiotherapy. Our aims were to investigate the relationship of cyclooxygenase-2 (Cox-2) expression to radiotherapy, and clinicopathologic/biologic variables in rectal cancers with or without radiotherapy. Methods and Materials: Cox-2 expression was immunohistochemically examined in distal normal mucosa (n = 28), in adjacent normal mucosa (n = 107), in primary cancer (n = 138), lymph node metastasis (n = 30), and biopsy (n = 85). The patients participated in a rectal cancer trial of preoperative radiotherapy. Results: Cox-2 expression was increased in primary tumor compared with normal mucosa (p < 0.0001), but there was no significant change between primary tumor and metastasis. Cox-2 positivity was or tended to be related to more p53 and Ki-67 ...
Potential role of intensity-modulated radiotherapy in the treatment of tumors of the maxillary sinus. Purpose: To assess 3-dimensional conformal radiotherapy (3D- CRT) and intensity-modulated. radiotherapy (IMRT) techniques to see whether doses to critical structures could be reduced while maintaining planning target volume (PTV) coverage in patients receiving conventional radiotherapy (RT) for carcinoma of the maxillary sinus because of the risk of radiation-induced complications, particularly visual loss. Methods and Materials: Six patients who had recently received conventional RT for carcinoma of the maxillary sinus were studied. Conventional RT, 3D-CRT, and step-and-shoot IMRT plans were prepared using the same 2-field arrangement. The effect of reducing the number of segments in the IMRT beams was investigated. Results: 3D-CRT and IMRT reduced the brain and ipsilateral parotid gland doses compared with the conventional ...
Purpose: Although intraoperative radiotherapy (IORT) is known to be a method that can reduce local recurrence in locally advanced colorectal cancer, it is not widely used. The aim of this study was to report our experience with IORT for locally advanced rectal cancer. Methods: From 1991 to 1994, nine patients with locally advanced rectal cancer received IORT. External beam radiotherapy was given postoperatively in five patients and preoperatively in three. Seven patients received chemotherapy. IORT was done with 6-MeV or 9-MeV electrons, and 12 Gy was irradiated at the tumor bed. The median follow-up period was 84 months (range, 15 to 208 months). Results: The median age of patients was 51 years (range, 42 to 73 years). All patients had advanced clinical T-stage (cT3/4)cancer. The overall and the disease-free survival rates were 66.7% and 66.7% at 5 years, respectively. One patient developed a local recurrence near the anastomosis site, which was out of the IORT field. Four ...
During external beam radiation therapy, a beam (or multiple beams) of radiation is directed through the skin to the cancer and the immediate surrounding area to destroy the tumor and any nearby cancer cells.
Post-radiation fractures after radiotherapy are prevalent in specific anatomic locations, such as the pelvis following urologic or gynecologic cancer treatment,...
CRAWLEY, U.K., April 29, 2013 /PRNewswire/ -- Hospitals in London and Dorset have acquired the final two of ten advanced Varian Medical Systems (NYSE: VAR [1]) radiotherapy treatment machines offered as part of an innovative government program to roll out the most modern cancer treatments for patients in the UKs public hospitals. North Middlesex University Hospital and Poole Hospital NHS Foundation Trust have ordered TrueBeam™ medical linear accelerators via an NHS Supply Chain initiative aimed at stimulating replacements of older treatment machines with state-of-the-art systems.. For North Middlesex University Hospital, the TrueBeam ordered earlier this year replaces an older radiotherapy machine and will enable the hospital to introduce advanced radiotherapy techniques such as image-guided radiotherapy (IGRT), stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS) for the first time, along with fast and ...
Modern radiotherapy machines can now deliver highly targeted radiotherapy treatment. However, the use of high precision radiotherapy techniques is extremely demanding in terms of hours spent, from the physician who defines the tumour target and healthy tissues, to the physicist who has to calculate a plan of optimum beam angles and trajectories for the treatment, and the radiographer, who must ensure that the treatment is delivered accurately to the target every day during a six or seven week course of radiotherapy. Accel-RT is an innovative partnership between oncologists, physicists and computer scientists at the Universities of Cambridge and Oxford. Over the next three years the collaborators will develop software tools and processes that will speed up the process of planning of radiotherapy. Once completed, free software tools will be available to radiotherapy treatment centres. These tools will increase ...
Objectives: The main aims of study were to compare toxicity profile of IMRT with conventional Radiotherapy (2D RT) in head and neck cancer. Methods: The Study was a prospective one in which we included Eligible patients known case of head and neck cancer like oral cavity, nasopharaynx, oropharaynx, and hypopharyanx to received either definitive chemoradiation alone or adjuvant. Eligible patients in conventional group randomized to receive radiotherapy with parallel opposed lateral fields and one direct anterior lower neck. In IMRT group patients received either 7 fields or 5 fields or parotid sparing radiation. Patients Toxicity pattern (grades of mucositis, skin reaction, xerostomia, odynophagia) of both groups was noted down. Toxicity of Radio-Therapy (RT) developing within 90 days and more than 90 days from the beginning of RT assessed according to Radiation Therapy Oncology Group (RTOG) ...
The Cancer Research UK study found that two different approaches to giving radiotherapy controlled the disease and had a low risk of severe side effects.. This part of the BC2001 radiotherapy study, led by researchers at The Institute of Cancer Research, London, and the University of Birmingham, compared giving radiotherapy to the whole bladder with targeted radiotherapy focused on the tumour.. Both types of treatment prevented the tumour from returning for over 60 per cent of patients for at least two years. And for many whose disease returned, it was not aggressive and only needed local treatment.. After five years of follow-up the survival rates were around 40 per cent for both radiotherapy approaches, a figure comparable to patients who have surgery to remove their bladder. In addition, patients receiving either type of radiotherapy had a low risk of severe side effects.. The standard treatment for ...
Patients who were treated with either definitive or postoperative radiation or chemoradiation therapy for HNC with moderate to severe levels of patient reported fatigue, at 6 or more weeks after completing all planned cancer therapy. Patients who rated their fatigue level at 5 or greater on a 0 to 10 scale during any follow-up clinic visits at MD Anderson ...
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Background: Radiation is implicated in the induction of second malignancies in children with bilateral retinoblastoma. There is a need to determine whether this risk can be justified by good visual outcome when external beam radiotherapy (EBRT) is used as a salvage treatment.. Aim: To study the effectiveness of EBRT as a salvage treatment after failed primary chemotherapy and focal treatment in bilateral retinoblastoma.. Methods: This is a retrospective observational case series. The outcome measures after EBRT are: rate of eye preservation, rate of tumour control, visual potential, visual acuity, and radiation-induced side-effects.. Results: Thirty-six eyes (22 patients) were included. The median follow-up after EBRT was 40 months (19-165 months). Thirty-two eyes received lens-sparing radiotherapy and 4 received whole-eye radiation. The rate of eye preservation was 83.3% (30/36 eyes). Twenty-four eyes (66.6%) were ...
January 31, 2011 - An oncology systems provider has launched The Year of Radiotherapy, an initiative to raise awareness of radiotherapy as a cost-effective, cutting-edge treatment that can help cure cancer. Oncology Systems Limited (OSL) launched the program in response to data from Cancer Research UK.. According to figures published by Cancer Research UK, only one in 10 people know that radiotherapy helps cure 40 percent of cancer patients. A report from the national charity estimates that only 38 percent of cancer patients in England are getting radiotherapy, although research shows that up to 50 percent might benefit. "We need to dispel the myths about radiotherapy and associated side effects and make people more aware of the benefits of the latest treatments," said Julie Mead, clinical director of OSL. "But we also need to make sure that these treatments are available across the country. The U.K. lags behind America and ...
This technology provides a method for monitoring cellular death in radiotherapy patients using low-frequency ultrasound. It combines conventional frequency (5-10 MHz) ultrasound with new software to detect responses to radiotherapy in breast cancer tissues.. ...
Request for buying: Global Radiotherapy Market - Industry Trends and Forecast to 2024. Table of Contents:. 1. INTRODUCTION. 1.1. OVERVIEW OF THE GLOBAL RADIOTHERAPY MARKET. 1.2. MARKET SEGMENTATION & COVERAGE. 1.2.1. CURRENCY AND PRICING. 1.2.2. LIMITATION. 1.2.3. STAKEHOLDERS. 2. RESEARCH METHODOLOGY. 2.1. KEY TAKEAWAYS. 2.2. ARRIVING AT THE GLOBAL RADIOTHERAPY MARKET SIZE. 2.2.1. MARKET CRACKDOWN APPROACH. 2.2.2. COMPANY REVENUE AND MARKET SHARE ANALYSIS. 2.2.3. DATA TRIANGULATION. 2.2.4. KEY DATA POINTS FROM PRIMARY SOURCES. 2.2.5. PRODUCT PIPELINE ANALYSIS. 2.2.6. PORTERS FIVE FORCES MATRIX. 2.3. GLOBAL RADIOTHERAPY MARKET: RESEARCH SNAPSHOT. 2.4. ASSUMPTIONS. 3. MARKET OVERVIEW. 4. EXECUTIVE SUMMARY. 4.1. OVERVIEW. 4.2. GLOBAL RADIOTHERAPY MARKET: KEY PRIMARY INSIGHTS. 4.3. MARKET OVERVIEW. 4.3.1. DRIVERS. 4.3.2. RESTRAINTS. 4.3.3. OPPURTUNITIES. 4.3.4. THREATS. 4.4. KEY MARKET TRENDS AND UPCOMING TECHNOLOGIES. 5. ...
The benefit of adjuvant radiotherapy (ART) for extrahepatic cholangiocarcinoma (EHCC) and gallbladder carcinoma (GBC) is unclear, with conflicting results from nonrandomized studies. We reported a meta-analysis to determine the impact of adjuvant radiotherapy on survival. PubMed, EMBASE, Cochrane Library and CNKI databases were searched to identify clinical trials of postoperative ART versus no radiotherapy for EHCC and GBC. The obtained data were analyzed using RevMan 5.3 and Stata 14.0 statistical software. Differences between two groups were estimated by calculating the odds ratio (OR) and 95% confidence interval (CI). A total of 21 clinical trials involving 1465 EHCC and GBC patients were selected according to the inclusion and exclusion criteria and included in this meta-analysis. The meta-analysis showed the following: The 5-year overall survival (OS) rate was higher in the ART group ...
Proctitis is defined as a condition of inflammation of the anus and the lining of the rectum (i.e., the distal 10-12 cm) of that can lead to bowl discomfort, bleeding, a discharge of mucus or pus, etc. VI. Treatments A. In conventional medicine perspective Medical treatment of proctitis depends on the etiology A.1. Radiation proctitis …. ...
TY - JOUR. T1 - Radiation-related new primary solid cancers in the childhood cancer survivor study. T2 - Comparative radiation dose response and modification of treatment effects. AU - Inskip, Peter D.. AU - Sigurdson, Alice J.. AU - Veiga, Lene. AU - Bhatti, Parveen. AU - Ronckers, Cécile. AU - Rajaraman, Preetha. AU - Boukheris, Houda. AU - Stovall, Marilyn. AU - Smith, Susan. AU - Hammond, Sue. AU - Henderson, Tara O.. AU - Watt, Tanya C.. AU - Mertens, Ann C.. AU - Leisenring, Wendy. AU - Stratton, Kayla. AU - Whitton, John. AU - Donaldson, Sarah S.. AU - Armstrong, Gregory T.. AU - Robison, Leslie L.. AU - Neglia, Joseph P.. PY - 2016/3/15. Y1 - 2016/3/15. N2 - Objectives The majority of childhood cancer patients now achieve long-term survival, but the treatments that cured their malignancy often put them at risk of adverse health outcomes years later. New cancers are among the most serious of these late effects. The aims of this review are to compare and contrast ...
Methods: We reviewed 76 patients with pT2-3N0M0 prostate cancer who underwent salvage radiotherapy for post-prostatectomy biochemical recurrence at the following three timings: ultra-early salvage radiotherapy (n = 20) delivered before meeting a current definition of biochemical recurrence (two consecutive prostate-specific antigen [PSA] values ≥0.2 ng/mL); early salvage radiotherapy (n = 40) delivered after meeting the definition but before PSA reached 0.5 ng/mL; and delayed salvage radiotherapy (n = 16) delivered after PSA reached 0.5 ng/mL. The primary endpoint was failure of salvage radiotherapy, defined as a PSA value ≥0.2 ng/mL. The log-rank test and Cox proportional hazards model were used for univariate and multivariate analyses, respectively ...
Radiotherapy could function as immunosuppressive agent for allotransplantation due to the ability of ionizing radiation to cause cell death, the technique could be applied to irradiate total body, bone marrow and/or lymphoid tissues of the recipient who receive an allograft as an immunosuppressant to improve the success rate of transplantation. From the past to the present, the radiation techniques in allotransplantation process have been continuously studied and developed across preclinical and clinical settings, in order to achieve better therapeutic outcomes. Currently, total lymphoid irradiation by fractionation and total body irradiation with low dose are most frequently used radiotherapy techniques in allotransplantation process. The advanced radiotherapy techniques such as total marrow and/or lymphoid irradiation by volumetric arc therapy (VMAT) or helical tomotherapy ...
Treatment of Premature ovarian failure refers to a loss of normal function of your ovaries before the age of 40. If your ovaries fail, they dont produce normal amounts of the hormone estrogen - which can lead to infertility and other problems. Premature ovarian failure affects about 1 percent of U.S. women, Premature ovarian failure is sometimes referred to as premature menopause, but the two conditions are not exactly the same: Women with premature menopause stop having periods, while women with premature ovarian failure may have sporadic periods for years - and may even become pregnant, Restoring estrogen levels in women with premature ovarian failure helps prevent some complications, such as osteoporosis, but infertility is difficult to treat. Women having problems conceiving a child may choose to explore other means of expanding their families, Premature Menopause, Premature Menopause Causes, Premature Menopause Symptom, Premature Menopause Treatment, Premature Menopause Signs, Early Pre Menopause,
Boron neutron capture therapy, or BNCT, is a two-part therapy that enhances the effect of radiation on cancer cells while minimizing the effect on nearby healthy cells.. Inadvertant damage to non-cancerous tissue is a major side effect of conventional radiation therapies, especially in the treatment of brain tumors. Conventional radiation therapy also requires several bouts of treatment, an inconvenience for many patients.. BNCT avoids these pitfalls by using radiation from BNLs medical reactor and a drug containing the element boron. Called BPA for boronophenylalanine, the drug is injected into the patient and travels through the bloodstream, concentrating preferentially in tumor tissue.. By itself BPA is harmless, but when exposed to a beam of neutrons from the reactor, the boron atoms capture neutrons, creating secondary effects that kill cells in the immediate vicinity.. Clinical trials of BNCT have been under way at BNL since 1994. ...
Thiagarajan, A., Lin, K., Lu, J.J., Tan, L.K.S., Loh, T.K.S., Goh, B.C., Lin, K., Tiong, C.E. (2006). Sequential external beam radiotherapy and high-dose-rate intracavitary brachytherapy in T1 and T2 nasopharyngeal carcinoma: An evaluation of long-term outcome. Laryngoscope 116 (6) : 938-943. [email protected] Repository. https://doi.org/10.1097/01.MLG.0000215173.14473. ...
We report on 2 cases of hypothyroidism presenting clinical symptoms that occurred after radiotherapy for cancer of the head and neck and on the results of estimating thyroid function in patients with head and neck cancer who received radiotherapy.. The first patient underwent total laryngectomy for laryngeal cancer without sacrificing the thyroid gland and partial gastrectomy for gastric cancer. Radiotherapy of the neck was carried out postoperatively.. Two years later, the patient developed chest pain; pericardial effusion was detected, leading to a diagnosis of myxedema caused by hypothyroidism. The second patient received radiotherapy alone for laryngeal cancer. Two months later, low serum sodium concentration and anemia were detected in this patient.. The cause of these changes was subsequently found to be hypothyroidism. Based on our experience with these 2 cases, we measured thyroid function in 35 patients who had undergone neck ...
Background Modified fractionation radiotherapy (RT), delivering multiple fractions per day or shortening the overall treatment time, improves overall survival for non-small cell lung cancer (NSCLC) patients over conventional fractionation RT (CRT). However, its cost-effectiveness is unknown. Objective: To examine and compare the cost-effectiveness of different modified RT schemes and CRT in the curative treatment of unresected NSCLC patients.. Methods A probabilistic Markov model was developed based on individual patient data from the Meta-Analysis of Radiotherapy in Lung Cancer (MAR-LC) with 10 randomized trials (N = 2000). Costs (Dutch healthcare perspective), quality-adjusted life years (QALYs) and net monetary benefits (NMB) were compared between 2 accelerated RT schemes (very accelerated (VART) and moderately accelerated (MART)), 2 hyperfractionated RT schemes (using an identical total treatment dose as CRT (HRTI) and higher total treatment dose as CRT (HRTH)) and CRT. ...
If radiation treatment has been recommended as part of your cancer treatment plan, consider Central Maryland Radiation Oncology. Here, the University of Maryland Medical Center and Johns Hopkins Medicine have partnered to offer the most advanced radiation cancer treatment available in a convenient, community location.. We offer patients with all stages and types of cancer the latest options in radiation treatment, from external beam radiation therapies such as stereotactic body radiotherapy (SBRT) and intensity-modulated radiotherapy (IMRT) to brachytherapy for prostate cancer, where tiny radioactive seeds are placed internally to kill cancer cells.. Most importantly, our patients have access to the same national clinical trials offered by our two major academic medical centers, but without the need to travel to the downtown campus locations.. Patients referred to Central Maryland ...
The aim of the study was to determine the efficacy and toxicity of alternate week concurrent 5-fluorouracil, hydroxyurea, and cisplatin with radiotherapy for locally advanced pancreatic adenocarcinoma. Patients received 5-fluorouracil, hydroxyurea and cisplatin with radiotherapy on an alternate week basis. Chemoradiotherapy was given day 1-5, and no therapy given day 6-14 for each 14 day cycle. Chemotherapy doses were as follows: hydroxyurea 1 mg every 12 h starting day 0, 5-fluorouracil 800 mg/m(2)/day for 5 days starting day 1, and cisplatin 20 mg/m(2) daily for 5 days every other cycle. A radiation dose of 6000 cGy was prescribed. Acute toxicities were monitored and therapy modified for hematologic toxicity. Nine patients enrolled, however eight were evaluable; one patient expired prior to therapy. The median radiation dose delivered was 5540 cGy. Sixty-three percent required a chemotherapy dose reduction. Fifty percent ...
In recent years, there has been increasing interest in evaluating the effect of dose per fraction in prostate cancer. Hypofractionated radiotherapy (HFRT) is a method that optimizes the fractions of radiotherapy, designed to increase daily fraction dose by delivering total dose in a shorter period of time. Several clinical data have suggested that the radiotherapeutic treatment of prostate cancer improves with hypofractionation (higher dose per fraction with an abbreviated general course of radiotherapy) [8,9]. The conventional fractionation scheme employing 1.8-2.0 Gy fractions is based on the premise that tumors are usually less sensitive to dose/daily low relative to normal tissues delayed response. The α/β ratio is a measure of the response fractionation low proportions associated with normal tissues that respond later. The unusual aspect of this radiobiology relates to high atypical prostate cancer sensitivity to high daily fractions of ...
Jul 8, 2010. TARGIT delivers local breast cancer control. Recently published results demonstrate that targeted intraoperative radiotherapy (TARGIT), which involves only selective irradiation of the breast, is equally effective in preventing local breast cancer recurrence as conventional whole-breast radiotherapy (Lancet doi: 10.1016/S0140-6736(10)60837-9).. http://medicalphysicsweb.org/cws/article/research/43137. ...
And Many Others……. Get a PDF Sample of Radiation Therapy Devices Market Research Report at: http://www.360marketupdates.com/enquiry/request-sample/10440027. After the basic information, the Radiation Therapy Devices Market report sheds light on the production. Production plants, their capacities, global production and revenue are studied. Also, the Radiation Therapy Devices Market growth in various regions and R&D status are also covered.. Following are Major Table of Content of Radiation Therapy Devices Industry:. • Radiation Therapy Devices Market Competition by Manufacturers. • Radiation Therapy Devices Production, Revenue (Value) by Region (2017-2022). • Radiation Therapy Devices Supply (Production), Consumption, Export, Import by Regions (2017-2022). • Radiation Therapy Devices Production, Revenue (Value), Price Trend by Type. • Radiation Therapy ...
Purpose/Objective(s): To evaluate the effects of various patient characteristics and radiation therapy treatment variables on outcomes in advanced-stage retinoblastoma. Methods and Materials: This was a retrospective review of 41 eyes of 30 patients treated with external beam radiation therapy between June 1, 1992, and March 31, 2012, with a median follow-up time of 133 months (11 years). Outcome measures included overall survival, progression-free survival, local control, eye preservation rate, and toxicity. Results: Over 90% of the eyes were stage V. Definitive external beam radiation therapy (EBRT) was delivered in 43.9% of eyes, adjuvant EBRT in 22% of eyes, and second-line/salvage EBRT in 34.1% of eyes. A relative lens sparing (RLS) technique was used in 68.3% of eyes and modified lens sparing (MLS) in 24.4% of eyes. Three eyes were treated with other techniques. Doses ≥45 Gy were used in 68.3% of eyes. Chemotherapy was ...
Purpose: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive cancers, and the current protocol of hyperfractionated accelerated radiotherapy was initiated to improve survival while limiting toxicities. Methods and Materials: All patients with ATC from 1991 to 2002 were accrued and received megavoltage radiotherapy from-the mastoid processes to the carina up to 60 Gy in twice-daily fractions of 1.8 and 2 Gy, 6 hours apart. Results: Thirty-one patients were accrued with a median age of 69 years, and 55% were women. Debulking was performed in 26%, and total thyroidectomy, in 6%, whereas 68% received radical radiotherapy alone. Local control data were available for 27 patients: 22% had a complete response, 26% had a partial response, 15% showed progressive disease, and 37% showed static disease. Median overall survival for all 31 patients was 70 days (95% confidence interval, 40-99). There was no significant difference in median survival between ...
Radiation enteropathy or radiation enteritis is a syndrome that may develop following abdominal or pelvic radiation therapy for cancer. Many affected people are cancer survivors who had treatment for cervical cancer or prostate cancer; it has also been termed pelvic radiation disease with radiation proctitis being one of the principal features. People who have been treated with radiotherapy for pelvic and other abdominal cancers frequently develop gastrointestinal symptoms. These include: rectal bleeding diarrhea and steatorrhea other defecation disorders including fecal urgency and incontinence. nutritional deficiencies and weight loss abdominal pain and bloating nausea, vomiting and fatigue Gastrointestinal symptoms are often found together with those in other systems including genitourinary disorders and sexual dysfunction. The burden of symptoms ...
Background and aim: Many patients with cancer experience emesis (nausea and vomiting) during radiotherapy. The overall aim of this thesis was to improve the situation for patients with risk for emesis during radiotherapy, by evaluating emesis in patients receiving verum (genuine) acupuncture, sham (simulated) acupuncture or standard care during radiotherapy.. Methods: In study I, a cross-sectional sample (n=368) treated with radiotherapy over various fields answered a study-specific questionnaire. In study II, 80 healthy volunteers were randomized to receive needling with verum acupuncture or non-penetrating telescopic sham needles by one of four physiotherapists. In study III, 215 patients were randomly allocated to verum (n=109) or non-penetrating telescopic sham (n=106) acupuncture during their entire radiotherapy period over abdominal or pelvic fields. The same 215 patients were also included in study ...
Accuray Incorporated, developer and manufacturer of the CyberKnife® System, announced that published data from two multicenter studies using differing protocols provide consistent results and reinforce the use of the CyberKnife system for the effective management of low-and intermediate-risk prostate cancer. The studies are the largest conducted to date evaluating stereotactic body radiation therapy (SBRT) in patients with localized prostate cancer.. Highlights of the multicenter studies included prostate SBRT administered by the system resulted in the following disease-free survival rates:. 97% - 100% for low-risk patients. - Superior to the 92% - 94% from conventional radiation therapy historic data. - Equivalent to low dose rate (LDR) brachytherapy and high dose rate (HDR) brachytherapy without the inconvenience and risk associated with invasive seed and catheter implants. 88% - 97% for intermediate-risk patients. - Equal to or higher than the 85% - 90% reported with ...
Radiotherapy of early breast cancer in scleroderma patients: our experience with four cases and a short review of the literature George Kyrgias1,2, Kiki Theodorou3,4, Anna Zygogianni1, Konstantinos Tsanadis2, Stefanos Zervoudis5, John Tzitzikas6, Michael Koukourakis71Academic Radiotherapy, University of Thessaly, Medical School, Greece; 2Radiation Oncology Department, University Hospital of Larissa, Greece; 3Academic Medical Physics, University of Thessaly, Medical School, Greece; 4Medical Physics Department, University Hospital of Larissa, 5Breast Unit, REA Hospital, Athens, Greece; 6Radiation Oncology Department, AHEPA University Hospital of Thessaloniki, Greece; 7Radiotherapy-Oncology Department, University Hospital of Alexandroupolis, GreecePurpose: Connective vascular diseases (CVD), including scleroderma, are reported to represent for some researchers a relative contraindication and for others absolute contraindication ...
Meningioma is a primary central nervous tumour (CNS) affecting mostly adults. Skull base meningiomas cause morbidity (and occasionally mortality) by compressing adjacent critical organs, and the aim of treatment is to optimise and preserve CNS function. Radiotherapy is an effective treatment for meningioma, with doses of 50-54Gy in conventional fractionation schedules resulting in long-term local control rates of 80-90%. However, local recurrence is unacceptably high in aggressive histological subtypes (WHO G2 and G3), and these patients have a poor outcome following standard dose regimens. In recent years Intensity-Modulated Radiotherapy (IMRT) has been developed, and can deliver highly conformal dose distributions with sharp dose gradients, making dose escalation a possibility for many tumours, including those located in the skull base. The aim of this thesis was to address two issues pertaining to the role of radiotherapy for skull base meningioma. ...
The search for the optimal choice of treatment time, dose and fractionation regimen is one of the major challenges in radiation therapy. Several aspects of the radiation response of tumours and normal tissues give different indications of how the parameters defining a fractionation schedule should be altered relative to each other which often results in contradictory conclusions. For example, the increased sensitivity to fractionation in late-reacting as opposed to early-reacting tissues indicates that a large number of fractions is beneficial, while the issue of accelerated repopulation of tumour cells starting at about three weeks into a radiotherapy treatment would suggest as short overall treatment time as possible. Another tumour-to-normal tissue differential relevant to the sensitivity as well as the fractionation and overall treatment time is the issue of tumour hypoxia and reoxygenation.. The tumour oxygenation is one of the most influential factors ...
Introduction. Surgery is the primary treatment for stage 1 endometrial cancer, and radiotherapy can be used as adjuvant treatment. Medical literature has not defined the best adjuvant treatment for stage 1A endometrial cancer, histological grades 1 and 21. Teletherapy is advocated by some authors, high dose rate brachytherapy (HDRB) by others, and also low dose rate brachytherapy (LDRB) has been described2-7. There are also authors who question the use of any adjuvant radiotherapy8,9. A meta-analysis evaluated the benefit of adjuvant teletherapy in cancer of endometrium stage I. With four randomized controlled trials included, 1,770 patients were analyzed, with 870 in the treatment group and 900 in the control group. There was a reduction of 72% in the risk of loco-regional recurrence, p , 0.00001, with NNT (number needed to treat) of 16.7 ...
Radiotherapy (RT) is an image-intensive specialty in medicine that utilizes radiation for treatment of cancer. Similar to x-ray beam treatment, proton therapy (PT) utilizes high energy particle proton beam to kill cancer cells at the target region. Due to the physical properties of the proton beam, PT delivers dose with higher accuracy than conventional radiotherapy with x-ray beams and no exit dose. In PT, patient data are scattered in different systems within the oncology department which hinders the research on many topics such as whether PT with higher dose or different delivery schedules is more beneficial to reducing toxicity of prostate cancer patients. This research aims to introduce a data mining method and a treatment plan navigator utilizing the infrastructure and data repository of a PT electronic patient record (ePR) system that can ultimately help to minimize radiation toxicity in prostate cancer patients and improve patient ...
Secondary malignancies are infrequent sequelae of pituitary radiotherapy. The goal of the present case study is to analyze clinical features of a selected group of cases to define the special characte
In The study of "Soy isoflavones sensitize cancer cells to radiotherapy" by Hillman GG, Singh-Gupta V., posted in US National Library of Medicine National Institutes of Health, researchers found that Soy isoflavones could be an effective complementary treatment given that they inhibit the survival signaling pathways of various cancer cells through altered activation of APE1/Ref-1, NF-κB, and HIF-1α, which are genes essential for tumor cell survival, tumor growth, and angiogenesis, thus making such cells more sensitive to radiotherapy. Studies in which soy isoflavones were given in conjunction with radiotherapy to prostate cancer patients suggest that soy isoflavones might also mitigate the adverse effects of radiation on normal tissues, probably by acting as antioxidants. These observations open new avenues for exploiting soy isoflavones as supplements to conventional therapies ...
TY - JOUR. T1 - Hypothyroidism After Radiotherapy for Nasopharyngeal Cancer Patients. AU - Wu, Yuan Hua. AU - Wang, Hung Ming. AU - Chen, Hellen Hi Wen. AU - Lin, Chien Yu. AU - Chen, Eric Yen Chao. AU - Fan, Kang Hsing. AU - Huang, Shiang Fu. AU - Chen, I. How. AU - Liao, Chun Ta. AU - Cheng, Ann Joy. AU - Chang, Joseph Tung Chieh. PY - 2010/3/15. Y1 - 2010/3/15. N2 - Purpose: The aim of this study was to determine the long-term incidence and possible predictive factors for posttreatment hypothyroidism in nasopharyngeal carcinoma (NPC) patients after radiotherapy. Methods and Materials: Four hundred and eight sequential NPC patients who had received regular annual thyroid hormone surveys prospectively after radiotherapy were included in this study. Median patient age was 47.3 years, and 286 patients were male. Thyroid function was prospectively evaluated by measuring thyroid-stimulating hormone (TSH) and serum free thyroxine (FT4) levels. Low FT4 levels ...

Randomized phase II exploratory study of prophylactic amifostine in cancer patients who receive radical radiotherapy to the...Randomized phase II exploratory study of prophylactic amifostine in cancer patients who receive radical radiotherapy to the...

Adjuvant radiotherapy was administered in 20 patients (15 with rectal cancer, 3 with cervical cancer, and 2 with pelvic sarcoma ... Radiotherapy dose. The mean total radiation dose was 50.4 Gy for the amifostine plus radiation group (A) and 50.2 Gy for the ... Endoscopic findings and grading of radiation colitis in cancer patients receiving external pelvic radiotherapy with or without ... External beam radiotherapy to the pelvis is related to the development of radiation colitis which is a consequence of radiation ...
more infohttps://jeccr.biomedcentral.com/articles/10.1186/1756-9966-29-68

Prospective Randomised Phase II Trial Evaluating Adjuvant Pelvic Radiotherapy Using Either IMRT or 3-Dimensional Planning for...Prospective Randomised Phase II Trial Evaluating Adjuvant Pelvic Radiotherapy Using Either IMRT or 3-Dimensional Planning for...

Radiation: 45 Gy / 25 fractions pelvic radiotherapy using intensity modulated radiotherapy (IMRT) followed by 11 Gy / 2 ... Radiation: 45 Gy/25 fractions Arm A 45 Gy/25 fractions pelvic radiotherapy using 3D planned technique followed by 11Gy/2 ... Radiation: 45 Gy/25 fractions Arm A 45 Gy/25 fractions pelvic radiotherapy using 3D planned technique followed by 11Gy/2 ... Radiation: 45 Gy/25 fraction external beam pelvic radiotherapy delivered using a 3-dimensional planned technique followed by 11 ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01164150

Diagnosis and Management of Endometrial Cancer - - American Family PhysicianDiagnosis and Management of Endometrial Cancer - - American Family Physician

Radiation and chemotherapy can also play a role in treatment. Low- to medium-risk endometrial hyperplasia can be treated with ... Adjuvant Radiotherapy. Radiation therapy does not affect overall survival in patients with low-grade carcinoma. It is ... A pelvic examination should be performed to evaluate for other sources of abnormal bleeding, such as the vagina or cervix. The ... Adjuvant radiotherapy for stage I endometrial cancer. Cochrane Database Syst Rev. 2012;(3):CD003916. ...
more infohttps://www.aafp.org/afp/2016/0315/p468.html

Study of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) for Patients With Rising Prostate-Specific Antigen (PSA) -...Study of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) for Patients With Rising Prostate-Specific Antigen (PSA) -...

... brachytherapy with or without pelvic external beam radiation; or radical prostatectomy with or without adjuvant or salvage ... Prior definitive therapy for primary prostate cancer consisting of:external beam radiotherapy; ... Patients treated with adjuvant or salvage radiation therapy following radical prostatectomy are eligible provided:Post ... Therapeutic PSA response to primary therapy below 1.0 ng/ml post radiation therapy or below 0.4 ng/ml for radical prostatectomy ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00678054

Long-term results of a prospective, Phase II study of long-term androgen ablation, pelvic radiotherapy, brachytherapy boost,...Long-term results of a prospective, Phase II study of long-term androgen ablation, pelvic radiotherapy, brachytherapy boost,...

... and adjuvant docetaxel in patients with high-risk prostate cancer. METHODS AND MATERIALS Eligibility included biopsy-proven ... external radiation, brachytherapy, and upfront docetaxel in high-risk prostate cancer is well tolerated, produces encouraging ... Treatment consisted of 45 Gy of pelvic EBRT, followed 1 month later by PB with either iodine-125 or Pd-103. One month after PB ... pelvic radiotherapy (EBRT), permanent transperineal prostate brachytherapy boost (PB), ...
more infohttps://www.semanticscholar.org/paper/Long-term-results-of-a-prospective%2C-Phase-II-study-Dibiase-Hussain/3c4031398e9006e608a4f3c7b73aad5dc4d9b473

Articular cartilage degeneration in post-collapse osteonecrosis of the femoral head. Radiographic staging, macroscopic grading,...Articular cartilage degeneration in post-collapse osteonecrosis of the femoral head. Radiographic staging, macroscopic grading,...

9424006 - Hyperfractionated radiation in combination with local hyperthermia in the treatment of .... 23766836 - Isolated ... 1947216 - Acute mucositis in the stimulated oral mucosa of patients during radiotherapy for head .... ... 7340986 - Delayed recovery of peripheral blood cell numbers after adjuvant cytotoxic chemotherapy.... ... cervical lymph node metastasis of renal pelvic squamous cell carcinoma: a case.... ...
more infohttp://www.biomedsearch.com/nih/Articular-cartilage-degeneration-in-post/15930536.html

What is the efficacy of combined radiotherapy and androgen ablation for the treatment of prostate cancer?What is the efficacy of combined radiotherapy and androgen ablation for the treatment of prostate cancer?

Phase III trial comparing whole-pelvic versus prostate-only radiotherapy and neoadjuvant versus adjuvant combined androgen ... Isamettin Andrew Aral, MD, MS Radiation Oncologist, ProHEALTH Radiation Oncology. Isamettin Andrew Aral, MD, MS is a member of ... any T-T4 without pelvic lymph node involvement) with radiotherapy followed by adjuvant androgen ablation for 3 years ... Adjuvant and Salvage Radiotherapy after Prostatectomy: ASTRO/AUA Guideline. American Urological Association. Available at http ...
more infohttps://www.medscape.com/answers/454283-157638/2006464-overview

What is the role of portal imaging in image-guided radiotherapy (IGRT) for the treatment of prostate cancer?What is the role of portal imaging in image-guided radiotherapy (IGRT) for the treatment of prostate cancer?

Phase III trial comparing whole-pelvic versus prostate-only radiotherapy and neoadjuvant versus adjuvant combined androgen ... Isamettin Andrew Aral, MD, MS Radiation Oncologist, ProHEALTH Radiation Oncology. Isamettin Andrew Aral, MD, MS is a member of ... Adjuvant and Salvage Radiotherapy after Prostatectomy: ASTRO/AUA Guideline. American Urological Association. Available at http ... Stereotactic Body Radiation Therapy Versus Intensity-Modulated Radiation Therapy for Prostate Cancer: Comparison of Toxicity. J ...
more infohttps://www.medscape.com/answers/454283-157630/2006464-overview

The Hospital for Sick Children - Challenges to diagnosing colorectal cancer during pregnancyThe Hospital for Sick Children - Challenges to diagnosing colorectal cancer during pregnancy

Adjuvant radiotherapy is used in the management of rectal cancer. Radiation therapy to the pelvis is not recommended during ... Fetal radiation exposure should be measured by a medical physicist in any radiation during pregnancy.32 Pelvic radiation after ... Adjuvant chemotherapy with 5-fluorouracil (5-FU) is suggested for stage III tumours; however, the risk and benefits should be ... Andreadis C, Charalampidou M, Diamantopoulos N, Chouchos N, Mouratidou D. Combined chemotherapy and radiotherapy during ...
more infohttp://www.motherisk.org/prof/updatesDetail.jsp?content_id=913

Testicular Cancer Treatment & Management: Medical Care, Surgical Care, Fertility and Sperm BankingTesticular Cancer Treatment & Management: Medical Care, Surgical Care, Fertility and Sperm Banking

Options after orchiectomy include active surveillance, adjuvant chemotherapy, and adjuvant radiation therapy. Median time to ... for patients with horseshoe or pelvic kidney or inflammatory bowel disease and for those who have received prior radiotherapy. ... Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomised trial. Lancet. 2005 Jul 23- ... Adjuvant radiation therapy consists of delivery of 20-30 Gy to the infradiaphragmatic area, including the para-aortic lymph ...
more infohttps://emedicine.medscape.com/article/279007-treatment

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Esophageal CancerCombination Chemotherapy Plus Radiation Therapy in Treating Patients With Esophageal Cancer

Radiotherapy:. - No prior radiotherapy for esophageal cancer including adjuvant radiotherapy. - No prior mantle, chest, pelvic ... and 29 and radiotherapy once daily 5 days a week for 5-6 weeks.. Cohorts of 3-6 patients receive escalating doses of irinotecan ... Prior resection without adjuvant therapy with local regional failure. - Positive microscopic margin on resection of all gross ... chemotherapy followed by concurrent chemotherapy and radiotherapy.. OUTLINE: This is a dose escalation study of irinotecan.. ...
more infohttp://www.knowcancer.com/cancer-trials/NCT00005638/

Radiation Oncology/Prostate/RTOG Prostate - Wikibooks, open books for an open worldRadiation Oncology/Prostate/RTOG Prostate - Wikibooks, open books for an open world

Phase III trial of short term androgen deprivation with pelvic lymph node or prostate bed only radiotherapy (SPPORT)in prostate ... A Phase III Study of the Treatment of Pathologic Stage C Carcinoma of the Prostate With Adjuvant Radiotherapy. ... Radiation Oncology‎ , Prostate(Redirected from Radiation Oncology/Prostate:RTOG Prostate). This page may need to be reviewed ... Phase II Megestrol Acetate vs Diethylstilbestrol Adjuvant to Radiotherapy for Locally Advanced Stage B/C Carcinoma of the ...
more infohttps://en.wikibooks.org/wiki/Radiation_Oncology/Prostate:RTOG_Prostate

Advances in the Treatment of Gynecologic Malignancies | Cancer Network | The Oncology JournalAdvances in the Treatment of Gynecologic Malignancies | Cancer Network | The Oncology Journal

Adjuvant postoperative radiotherapy in an intermediate-risk group of 1 ... Adjuvant Treatment of. Organ-Confined Disease. • GOG-99 Roberts et al evaluated surgery vs surgery plus. adjuvant radiotherapy ... Postoperative Radiation Therapy in Endometrial Cancer (PORTEC) study group[10]. investigated whether postoperative pelvic ... recurrence rate was 12% without radiotherapy vs 1.7% with radiotherapy.. Two-thirds of the pelvic recurrences were in the ...
more infohttp://www.cancernetwork.com/review-article/advances-treatment-gynecologic-malignancies

Capecitabine and Radiation Therapy in Treating Patients With Locally Advanced Cervical Cancer or Other Pelvic CancerCapecitabine and Radiation Therapy in Treating Patients With Locally Advanced Cervical Cancer or Other Pelvic Cancer

Prior adjuvant hormonal therapy allowed. Radiotherapy. - Recovered from prior radiotherapy. - At least 4 weeks since prior ... Prior radiotherapy for a non-gynecologic malignancy allowed. - No prior low abdominal or pelvic radiotherapy. Surgery. - Not ... Phase I Study of Capecitabine (Xeloda) and Radiation Therapy in Patients With Locally Advanced Cervical and Pelvic Malignancies ... Phase I Study of Capecitabine (Xeloda) and Radiation Therapy in Patients With Locally Advanced Cervical and Pelvic Malignancies ...
more infohttp://www.knowcancer.com/cancer-trials/NCT00118300/

Method of using a surgical repair mesh - American Cyanamid CompanyMethod of using a surgical repair mesh - American Cyanamid Company

A polyglycolic acid mesh sling sewn above the pelvic inlet prevents small bowel descent into the true pelvis during radiation ... be useful for patients with the need for adjuvant radiotherapy or in those with known pelvic recurrences requiring radiation ... Radiation enteritis is also a complication seen in patients receiving irradiation therapy, e.g., for perineal, pelvic, or intra ... A polyglycolic acid mesh sling sewn above the pelvic inlet prevents small bowel descent into the true pelvis during radiation ...
more infohttp://www.freepatentsonline.com/4655221.html

Retreatment for recurrent prostate cancer | OncoLinkRetreatment for recurrent prostate cancer | OncoLink

Do you use a higher then conventional dose of radiation and would you radiate the pelvic bed as well in a Gleason 6 tumor? ... 5 years ago showed what appeared to be a positive surgical margin however he decided not to proceed with adjuvant radiotherapy ... Three-Dimensional Conformal Radiotherapy DAmico Risk Categories Rising PSA Level PSA Level for Radiation Therapy after Surgery ... The dose of radiation is actually lower then patients that never had surgery. We treat only the prostate bed and anastamosis to ...
more infohttps://www.oncolink.org/frequently-asked-questions/cancers/prostate/retreatment-for-recurrent-prostate-cancer

Mohindra, Pranshu  | University of Maryland School of MedicineMohindra, Pranshu | University of Maryland School of Medicine

Adjuvant Whole Pelvic Radiation Therapy (WPRT) for Endometrioid Adenocarcinoma (EA): 45 Gy or 50/50.4 Gy? IJROBP, 2016:96(2), ... Monthly palliative pelvic radiotherapy in advanced carcinoma of uterine cervix. Journal of Cancer Research & Therapeutics. 2005 ... 2009 - 2010: Clinical Fellow: Radiation Oncology (Head and Neck Cancer)Radiation Medicine Program, Princess Margaret Hospital, ... phase clinical trials evaluating both radiation sensitizers and radiation toxicity mitigators or evaluation of modern radiation ...
more infohttps://www.medschool.umaryland.edu/profiles/Mohindra-Pranshu/

Palliative beam radiotherapy offered real-world survival benefit to metastatic rectal cancer: A large US population-based and...Palliative beam radiotherapy offered real-world survival benefit to metastatic rectal cancer: A large US population-based and...

The role of adjuvant pelvic radiotherapy in rectal cancer with synchronous liver metastasis: a retrospective study. Radiation ... No Radiotherapy (n (n%)). Radiotherapy (n (n%)). P value. No Radiotherapy (n (n%)). Radiotherapy (n (n%)). P value. ... No Radiotherapy (n (n%)). Radiotherapy (n (n%)). P value. No Radiotherapy (n (n%)). Radiotherapy (n (n%)). P value. ... No Radiotherapy (n (n%)). Radiotherapy (n (n%)). P value. No Radiotherapy (n (n%)). Radiotherapy (n (n%)). P value. ...
more infohttps://www.jcancer.org/v10p1216.htm

Radiation Oncology/Endometrium/Locally Advanced Stage - Wikibooks, open books for an open worldRadiation Oncology/Endometrium/Locally Advanced Stage - Wikibooks, open books for an open world

Pelvic RT vs. Adjuvant chemotherapy[edit]. *JGOG 2033 (1994-2000) -- adjuvant CAP vs adjuvant pelvic RT *Randomized. 103 ... GOG 94 (1986-94) - Whole abdominal radiotherapy in the adjuvant treatment of patients with stage III and IV endometrial cancer ... Arm 1) adjuvant RT only vs Arm 2) adjuvant chemotherapy and radiation therapy. Pelvic RT 45/25, PA-field as needed to L1/L2. ... only positive pelvic lymph nodes). Arm 1) adjuvant RT only vs Arm 2) adjuvant chemotherapy and radiation therapy. Sequence of ...
more infohttps://en.wikibooks.org/wiki/Radiation_Oncology/Endometrium/Locally_Advanced_Stage

ANZCTR - RegistrationANZCTR - Registration

Adjuvant chemo-radiation followed by chemotherapy. Patients will be treated with adjuvant pelvic radiotherapy plus concurrent ... A phase II trial to evaluate the effect on progression-free survival of adjuvant chemo-radiation followed by chemotherapy with ... Patients who have been treated for other malignancies must not have received prior pelvic or abdominal radiotherapy, and any ... A phase II trial of adjuvant chemo-radiation followed by chemotherapy for patients with newly diagnosed endometrial carcinoma ...
more infohttps://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=790

ANZCTR - RegistrationANZCTR - Registration

Adjuvant chemo-radiation followed by chemotherapy. Patients will be treated with adjuvant pelvic radiotherapy plus concurrent ... A phase II trial to evaluate the effect on progression-free survival of adjuvant chemo-radiation followed by chemotherapy with ... Patients who have been treated for other malignancies must not have received prior pelvic or abdominal radiotherapy, and any ... A phase II trial of adjuvant chemo-radiation followed by chemotherapy for patients with newly diagnosed endometrial carcinoma ...
more infohttps://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=790

Evaluation of Male Sexual Dysfunction Associated with Laparoscopic versus Open Resection in Rectal Cancer in Different Age...Evaluation of Male Sexual Dysfunction Associated with Laparoscopic versus Open Resection in Rectal Cancer in Different Age...

Patients with stage T3 or T4 disease, without distant metastasis, were treated with preoperative neo-adjuvant chemo-radiation ( ... At 15 months postoperatively, the late side effects of adjuvant chemotherapy and radiotherapy, as well as the natural ... Pelvic radiation therapy itself may affect sexuality, but its role has not been clearly proven, as several studies were not ... The pelvic plexus, itself, is most at risk during lateral dissection at the level of the middle hemorrhoidal vessels. In APR, ...
more infohttps://scirp.org/journal/paperinformation.aspx?paperid=94902

Frontiers | The Comparison of Stereotactic Body Radiation Therapy and Intensity-Modulated Radiation Therapy for Prostate Cancer...Frontiers | The Comparison of Stereotactic Body Radiation Therapy and Intensity-Modulated Radiation Therapy for Prostate Cancer...

Descriptive statistics were used to describe toxicity graded by a modified RTOG late radiation morbidity scoring system. ... Descriptive statistics were used to describe toxicity graded by a modified RTOG late radiation morbidity scoring system. ... at a community hospital with two distinct radiation departments and referral patterns. Charts were reviewed for pretreatment ... at a community hospital with two distinct radiation departments and referral patterns. Charts were reviewed for pretreatment ...
more infohttps://www.frontiersin.org/articles/10.3389/fonc.2016.00184/full

Androgen Deprivation Therapy: A Survival Benefit or Detriment in Men With High-Risk Prostate Cancer?: Page 2 of 3 | Cancer...Androgen Deprivation Therapy: A Survival Benefit or Detriment in Men With High-Risk Prostate Cancer?: Page 2 of 3 | Cancer...

In the setting of dose escalation with modern radiotherapy, in conjunction with the latest concerns about cardiovascular ... that demonstrated improvements in biochemical control and survival with the addition of ADT to external beam radiotherapy, ... An update of the phase III trial comparing whole pelvic to prostate only radiotherapy and neoadjuvant to adjuvant total ... DAmico AV, Chen MH, Renshaw AA, et al: Androgen suppression and radiation vs radiation alone for prostate cancer: A randomized ...
more infohttp://www.cancernetwork.com/oncology-journal/androgen-deprivation-therapy-survival-benefit-or-detriment-men-high-risk-prostate-cancer/page/0/1

Do medicinal interventions reduce radiation-related bone fractures and risk of avascular necrosis in adults undergoing pelvic...Do medicinal interventions reduce radiation-related bone fractures and risk of avascular necrosis in adults undergoing pelvic...

... whether the evidence applies to people undergoing pelvic radiotherapy for other cancers and people not receiving adjuvant ... Research shows that pelvic radiotherapy can cause changes in pelvic bones, which may lead to fractures occurring from minimal ... Fractures due to normal stresses on weakened bone due to radiotherapy are termed insufficiency fractures. Pelvic radiotherapy- ... This review looked at the literature for medicines which may be given prior to or during pelvic radiotherapy, to determine if ...
more infohttps://www.cochrane.org/CD010604/GYNAECA_do-medicinal-interventions-reduce-radiation-related-bone-fractures-and-risk-avascular-necrosis
  • Patients with pelvic malignancies were considered for participation into this trial if they fulfilled a list of eligibility criteria [see below] and signed an informed consent. (biomedcentral.com)
  • The 5-year results of the RTOG 86-10 trial in patients with bilobar and more severe prostate carcinoma demonstrated that 4 months of total androgen blockade (TAB) in conjunction with conventional external beam radiotherapy (EBRT) was more beneficial than radiotherapy alone. (medscape.com)
  • For EBRT, intensity-modulated radiation therapy (IMRT) is increasingly being used to treat cervical cancer and has the potential to improve the therapeutic ratio because of its ability to escalate the dose to cancer targets while sparing adjacent healthy tissue . (termedia.pl)
  • Liu Q, Shan Z, Luo D, Cai S, Li Q, Li X. Palliative beam radiotherapy offered real-world survival benefit to metastatic rectal cancer: A large US population-based and propensity score-matched study. (jcancer.org)
  • Radiotherapy (RT) has been reported to effectively palliate many symptoms of patients with metastatic rectal cancer (mRC). (jcancer.org)
  • Renal cell cancer and melanoma are generally considered to be radioresistant but radiation therapy is still a palliative option for many patients with metastatic melanoma. (wikipedia.org)
  • To provide a single-institution analysis of the benefits of hormone therapy with radiotherapy in different non-metastatic prostate cancer scenarios. (springer.com)
  • In a single-institution analysis, the addition of hormone therapy to radiotherapy was advantageous in all settings of non-metastatic prostate cancer except that of the very earliest disease presentation. (springer.com)
  • Prostate cancer radiation dose response: results of the M. D. Anderson phase III randomized trial. (springer.com)
  • Following several randomized trials of patients with intermediate- to high-risk prostate cancer that demonstrated improvements in biochemical control and survival with the addition of ADT to external beam radiotherapy, there was a dramatic increase in the use of hormone therapy in the definitive setting. (cancernetwork.com)
  • Beneficial effect of combination hormonal therapy administered prior and following external beam radiation therapy in localized prostate cancer. (springer.com)
  • one evaluating VX-970, a novel DNA repair pathway inhibitor with whole brain radiotherapy (WBRT) in patients with brain metastases from NSCLC (CIRB and CTEP approved, NCT02589522, career development project team award) and another evaluating the combination of oral 5-iodo-2-pyrimidinone-2-deoxyribose (IPdR) with WBRT in brain metastases (CIRB and CTEP approved, NCT02993146). (umaryland.edu)
  • The depth of myometrial invasion and grade of tumor were the most important factors predicting pelvic node and para-aortic node metastases ( Table 1 ). (cancernetwork.com)
  • No other markers are currently available for accurate prediction of pelvic lymph node metastases. (aacrjournals.org)
  • Patients with lymph node metastases are therefore treated with adjuvant (chemo)radiation. (aacrjournals.org)
  • This review highlights the need for clinical trials using interventions prior to and during radiotherapy to prevent radiation-related bone morbidity , insufficiency fractures and avascular necrosis. (cochrane.org)
  • In the setting of dose escalation with modern radiotherapy, in conjunction with the latest concerns about cardiovascular morbidity with ADT, the magnitude of expected benefit along with potential risks of ADT use must be carefully considered for each patient. (cancernetwork.com)
  • Do you use a higher then conventional dose of radiation and would you radiate the pelvic bed as well in a Gleason 6 tumor? (oncolink.org)
  • To spare normal tissues (such as skin or organs which radiation must pass through to treat the tumor), shaped radiation beams are aimed from several angles of exposure to intersect at the tumor, providing a much larger absorbed dose there than in the surrounding, healthy tissue. (wikipedia.org)
  • Radiation therapy for a patient with a diffuse intrinsic pontine glioma , with radiation dose color-coded. (wikipedia.org)
  • Of the patient, disease, and treatment factors analyzed, only clinical T-stage (p = 0.002), radiation dose (p = 0.006), and hormone therapy (p = 0.016) reached statistical significance on multivariate analysis. (springer.com)
  • There are few case series describing outcomes, and still fewer that used high-dose rate (HDR) radiation, which is becoming commonplace. (oncologynurseadvisor.com)
  • Radiation therapy is commonly applied to the cancerous tumor because of its ability to control cell growth. (wikipedia.org)
  • Besides the tumour itself, the radiation fields may also include the draining lymph nodes if they are clinically or radiologically involved with tumor, or if there is thought to be a risk of subclinical malignant spread. (wikipedia.org)
  • The precise treatment intent (curative, adjuvant, neoadjuvant therapeutic , or palliative) will depend on the tumor type, location, and stage, as well as the general health of the patient. (wikipedia.org)
  • It is important to distinguish the radiosensitivity of a particular tumor, which to some extent is a laboratory measure, from the radiation "curability" of a cancer in actual clinical practice. (wikipedia.org)
  • There is insufficient evidence that zoledronic acid and other medicines prevent radiotherapy-induced bone complications. (cochrane.org)
  • The 5-year results from the European Organization for Research and Treatment of Cancer (EORTC) trial that compared radiotherapy alone for locally advanced disease (T1, T2 grade 3 disease, any T-T4 without pelvic lymph node involvement) with radiotherapy followed by adjuvant androgen ablation for 3 years demonstrated improved outcome, including a survival advantage for the combined modality arm. (medscape.com)
  • In addition, patients must be either:A. Patients with documented involvement of pelvic and/or para-aortic nodes by histology (FIGO stage IIIc) or post-operative PET, CT or PET/CTORB. (anzctr.org.au)
  • RTOG trial 92-02, which evaluated the role of continued androgen blockade for 2 years, found that PSA relapse-free survival, DFS, and local control were better with combined therapy (ie, TAB and radiotherapy) than with radiotherapy alone. (medscape.com)
  • Using the SEER database, we definitely demonstrated that RT was associated with a significant survival advantage beyond the relief of a variety of pelvic symptoms in the setting of mRC. (jcancer.org)
  • Currently, the combination of surgical techniques, diagnostics, radiotherapy and new oncologic drugs has contributed to improved outcomes in rectal cancer (RC), including prolonged survival in mRC [ 8 ]. (jcancer.org)
  • Median time to relapse in patients who do not receive adjuvant treatment is 12 months, but relapse can occur even beyond 5 years. (medscape.com)
  • Active surveillance is recommended for patients with horseshoe or pelvic kidney or inflammatory bowel disease and for those who have received prior radiotherapy. (medscape.com)
  • Radiation therapy has several applications in non-malignant conditions, such as the treatment of trigeminal neuralgia , acoustic neuromas , severe thyroid eye disease , pterygium , pigmented villonodular synovitis , and prevention of keloid scar growth, vascular restenosis , and heterotopic ossification . (wikipedia.org)
  • Radiotherapy plays an important role in early and advanced stages of the disease. (termedia.pl)
  • The records of 527 patients receiving radiotherapy for locally advanced, localized, and post-prostatectomy disease were reviewed. (springer.com)