Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
A thermogenic form of adipose tissue composed of BROWN ADIPOCYTES. It is found in newborns of many species including humans, and in hibernating mammals. Brown fat is richly vascularized, innervated, and densely packed with MITOCHONDRIA which can generate heat directly from the stored lipids.
Fatty tissue composed of WHITE ADIPOCYTES and generally found directly under the skin (SUBCUTANEOUS FAT) and around the internal organs (ABDOMINAL FAT). It has less vascularization and less coloration than the BROWN FAT. White fat provides heat insulation, mechanical cushion, and source of energy.
Fatty tissue under the SKIN through out the body.
Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Fatty tissue inside the ABDOMINAL CAVITY, including visceral fat and retroperitoneal fat. It is the most metabolically active fat in the body and easily accessible for LIPOLYSIS. Increased visceral fat is associated with metabolic complications of OBESITY.
The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues.
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
The differentiation of pre-adipocytes into mature ADIPOCYTES.
Fatty tissue under the SKIN in the region of the ABDOMEN.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
The generation of heat in order to maintain body temperature. The uncoupled oxidation of fatty acids contained within brown adipose tissue and SHIVERING are examples of thermogenesis in MAMMALS.
Fat cells with light coloration and few MITOCHONDRIA. They contain a scant ring of CYTOPLASM surrounding a single large lipid droplet or vacuole.
A continuous cell line that is a substrain of SWISS 3T3 CELLS developed though clonal isolation. The mouse fibroblast cells undergo an adipose-like conversion as they move to a confluent and contact-inhibited state.
Mutant mice exhibiting a marked obesity coupled with overeating, hyperglycemia, hyperinsulinemia, marked insulin resistance, and infertility when in a homozygous state. They may be inbred or hybrid.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.
Polypeptides produced by the ADIPOCYTES. They include LEPTIN; ADIPONECTIN; RESISTIN; and many cytokines of the immune system, such as TUMOR NECROSIS FACTOR-ALPHA; INTERLEUKIN-6; and COMPLEMENT FACTOR D (also known as ADIPSIN). They have potent autocrine, paracrine, and endocrine functions.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
A double-layered fold of peritoneum that attaches the STOMACH to other organs in the ABDOMINAL CAVITY.
A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.
An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34.
Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.
Consumption of excessive DIETARY FATS.
FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form.
The amount of fat or lipid deposit at a site or an organ in the body, an indicator of body fat status.
Fat cells with dark coloration due to the densely packed MITOCHONDRIA. They contain numerous small lipid droplets or vacuoles. Their stored lipids can be converted directly to energy as heat by the mitochondria.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
The relative amounts of various components in the body, such as percentage of body fat.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
General term for inflammation of adipose tissue, usually of the skin, characterized by reddened subcutaneous nodules.
The chemical reactions involved in the production and utilization of various forms of energy in cells.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Glucose in blood.
The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
An absence of warmth or heat or a temperature notably below an accustomed norm.
Any of the large interior organs in any one of the three great cavities of the body, especially in the abdomen.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
That portion of the body that lies between the THORAX and the PELVIS.
LIPOLYSIS of stored LIPIDS in the ADIPOSE TISSUE to release FREE FATTY ACIDS. Mobilization of stored lipids is under the regulation of lipolytic signals (CATECHOLAMINES) or anti-lipolytic signals (INSULIN) via their actions on the hormone-sensitive LIPASE. This concept does not include lipid transport.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Fatty tissue in the region of the ABDOMEN. It includes the ABDOMINAL SUBCUTANEOUS FAT and the INTRA-ABDOMINAL FAT.
De novo fat synthesis in the body. This includes the synthetic processes of FATTY ACIDS and subsequent TRIGLYCERIDES in the LIVER and the ADIPOSE TISSUE. Lipogenesis is regulated by numerous factors, including nutritional, hormonal, and genetic elements.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Deposits of ADIPOSE TISSUE throughout the body. The pattern of fat deposits in the body regions is an indicator of health status. Excess ABDOMINAL FAT increases health risks more than excess fat around the hips or thighs, therefore, WAIST-HIP RATIO is often used to determine health risks.
An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.
The processes of heating and cooling that an organism uses to control its temperature.
Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.
Either of two fleshy protuberances at the lower posterior section of the trunk or HIP in humans and primate on which a person or animal sits, consisting of gluteal MUSCLES and fat.
A collection of heterogenous conditions resulting from defective LIPID METABOLISM and characterized by ADIPOSE TISSUE atrophy. Often there is redistribution of body fat resulting in peripheral fat wasting and central adiposity. They include generalized, localized, congenital, and acquired lipodystrophy.
Loose connective tissue lying under the DERMIS, which binds SKIN loosely to subjacent tissues. It may contain a pad of ADIPOCYTES, which vary in number according to the area of the body and vary in size according to the nutritional state.
The consumption of edible substances.
Regular course of eating and drinking adopted by a person or animal.
Two populations of Zucker rats have been cited in research--the "fatty" or obese and the lean. The "fatty" rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene.
A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.
A 12-kDa cysteine-rich polypeptide hormone secreted by FAT CELLS in the ADIPOSE TISSUE. It is the founding member of the resistin-like molecule (RELM) hormone family. Resistin suppresses the ability of INSULIN to stimulate cellular GLUCOSE uptake.
THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The beta-3 adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.
The measurement of an organ in volume, mass, or heaviness.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Enzymes that catalyze the synthesis of FATTY ACIDS from acetyl-CoA and malonyl-CoA derivatives.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Removal of localized SUBCUTANEOUS FAT deposits by SUCTION CURETTAGE or blunt CANNULATION in the cosmetic correction of OBESITY and other esthetic contour defects.
A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3.
A glucose transport protein found in mature MUSCLE CELLS and ADIPOCYTES. It promotes transport of glucose from the BLOOD into target TISSUES. The inactive form of the protein is localized in CYTOPLASMIC VESICLES. In response to INSULIN, it is translocated to the PLASMA MEMBRANE where it facilitates glucose uptake.
A state of insufficient flesh on the body usually defined as having a body weight less than skeletal and physical standards. Depending on age, sex, and genetic background, a BODY MASS INDEX of less than 18.5 is considered as underweight.
Increase in BODY WEIGHT over existing weight.
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
The white of an egg, especially a chicken's egg, used in cooking. It contains albumin. (Random House Unabridged Dictionary, 2d ed)
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
Individuals whose ancestral origins are in the continent of Europe.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Hormones released from neoplasms or from other cells that are not the usual sources of hormones.
Transport proteins that carry specific substances in the blood or across cell membranes.
The condition of weighing two, three, or more times the ideal weight, so called because it is associated with many serious and life-threatening disorders. In the BODY MASS INDEX, morbid obesity is defined as having a BMI greater than 40.0 kg/m2.
An enzyme that catalyzes the formation of oleoyl-CoA, A, and water from stearoyl-CoA, AH2, and oxygen where AH2 is an unspecified hydrogen donor.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.
A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Abstaining from all food.
Decrease in existing BODY WEIGHT.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Agents that increase energy expenditure and weight loss by neural and chemical regulation. Beta-adrenergic agents and serotoninergic drugs have been experimentally used in patients with non-insulin dependent diabetes mellitus (NIDDM) to treat obesity.
Maintenance of a constant blood glucose level by perfusion or infusion with glucose or insulin. It is used for the study of metabolic rates (e.g., in glucose, lipid, amino acid metabolism) at constant glucose concentration.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Elements of limited time intervals, contributing to particular results or situations.
Lengthy and continuous deprivation of food. (Stedman, 25th ed)
Substances which lower blood glucose levels.
The withholding of food in a structured experimental situation.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Total number of calories taken in daily whether ingested or by parenteral routes.
Cell surface receptors for obesity factor (LEPTIN), a hormone secreted by the WHITE ADIPOCYTES. Upon leptin-receptor interaction, the signal is mediated through the JAK2/STAT3 pathway to regulate food intake, energy balance and fat storage.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A disorder characterized by the accumulation of encapsulated or unencapsulated tumor-like fatty tissue resembling LIPOMA.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Foodstuff used especially for domestic and laboratory animals, or livestock.
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The quantity of volume or surface area of CELLS.
Cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin.
The processes whereby the internal environment of an organism tends to remain balanced and stable.
Contractile tissue that produces movement in animals.
Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Adaptation to a new environment or to a change in the old.
Drugs that selectively bind to and activate beta-adrenergic receptors.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Defective metabolism leading to fat maldistribution in patients infected with HIV. The etiology appears to be multifactorial and probably involves some combination of infection-induced alterations in metabolism, direct effects of antiretroviral therapy, and patient-related factors.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
(Z)-9-Octadecenoic acid 1,2,3-propanetriyl ester.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING.
An enzyme that catalyzes the acyl group transfer of ACYL COA to 1-acyl-sn-glycerol 3-phosphate to generate 1,2-diacyl-sn-glycerol 3-phosphate. This enzyme has alpha, beta, gamma, delta and epsilon subunits.
Individuals whose ancestral origins are in the continent of Africa.
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.
A benign tumor composed of fat cells (ADIPOCYTES). It can be surrounded by a thin layer of connective tissue (encapsulated), or diffuse without the capsule.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
A family of structurally-related angiogenic proteins of approximately 70 kDa in size. They have high specificity for members of the TIE RECEPTOR FAMILY.
A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
GLYCEROL esterified with FATTY ACIDS.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
A collective term for a group of around nine geometric and positional isomers of LINOLEIC ACID in which the trans/cis double bonds are conjugated, where double bonds alternate with single bonds.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
The glyceryl esters of a fatty acid, or of a mixture of fatty acids. They are generally odorless, colorless, and tasteless if pure, but they may be flavored according to origin. Fats are insoluble in water, soluble in most organic solvents. They occur in animal and vegetable tissue and are generally obtained by boiling or by extraction under pressure. They are important in the diet (DIETARY FATS) as a source of energy. (Grant & Hackh's Chemical Dictionary, 5th ed)
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Reduction in caloric intake without reduction in adequate nutrition. In experimental animals, caloric restriction has been shown to extend lifespan and enhance other physiological variables.
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A large group of membrane transport proteins that shuttle MONOSACCHARIDES across CELL MEMBRANES.
One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.
An enzyme that catalyzes the conversion of (S)-malate and NAD+ to oxaloacetate and NADH. EC 1.1.1.37.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8.
An enzyme that catalyzes the formation of nicotinamide mononucleotide (NMN) from nicotinamide and 5-phosphoribosyl-1-pyrophosphate, the rate-limiting step in the biosynthesis of the NAD coenzyme. It is also known as a growth factor for early B-LYMPHOCYTES, or an ADIPOKINE with insulin-mimetic effects (visfatin).
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed)
Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
The portion of the leg in humans and other animals found between the HIP and KNEE.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma.
Carbohydrates present in food comprising digestible sugars and starches and indigestible cellulose and other dietary fibers. The former are the major source of energy. The sugars are in beet and cane sugar, fruits, honey, sweet corn, corn syrup, milk and milk products, etc.; the starches are in cereal grains, legumes (FABACEAE), tubers, etc. (From Claudio & Lagua, Nutrition and Diet Therapy Dictionary, 3d ed, p32, p277)
Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukemias and lymphomas.
The measure of the level of heat of a human or animal.
The technique that deals with the measurement of the size, weight, and proportions of the human or other primate body.
Congenital disorders, usually autosomal recessive, characterized by severe generalized lack of ADIPOSE TISSUE, extreme INSULIN RESISTANCE, and HYPERTRIGLYCERIDEMIA.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.
Refers to animals in the period of time just after birth.
Intracellular proteins that reversibly bind hydrophobic ligands including: saturated and unsaturated FATTY ACIDS; EICOSANOIDS; and RETINOIDS. They are considered a highly conserved and ubiquitously expressed family of proteins that may play a role in the metabolism of LIPIDS.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
An anti-inflammatory 9-fluoro-glucocorticoid.
Derivatives of ACETIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxymethane structure.
A type of diabetes mellitus that is characterized by severe INSULIN RESISTANCE and LIPODYSTROPHY. The latter may be generalized, partial, acquired, or congenital (LIPODYSTROPHY, CONGENITAL GENERALIZED).
FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.
Animal form of fatty acid synthase which is encoded by a single gene and consists of seven catalytic domains and is functional as a homodimer. It is overexpressed in some NEOPLASMS and is a target in humans of some ANTINEOPLASTIC AGENTS and some ANTI-OBESITY AGENTS.
A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
Retinol binding proteins that circulate in the PLASMA. They are members of the lipocalin family of proteins and play a role in the transport of RETINOL from the LIVER to the peripheral tissues. The proteins are usually found in association with TRANSTHYRETIN.

Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. (1/644)

The Rb family, Rb, p107, and p130, play important roles in cell cycle control and cellular differentiation, and Rb has been suggested to regulate adipocyte differentiation. We report here that mice lacking p107 displayed a uniform replacement of white adipose tissue (WAT) with brown adipose tissue (BAT). Mutant WAT depots contained mutilocular adipocytes that expressed elevated levels of PGC-1alpha and UCP-1 typical of BAT. WAT from p107-/- mice contained markedly elevated numbers of adipogenic precursors that displayed downregulated expression of pRb. Consistent with the hypothesis that pRb is required for adult adipocyte differentiation, Cre-mediated deletion of Rb in adult primary preadipocytes blocked their differentiation into white adipocytes. Importantly, pRb was observed to bind the PGC-1alpha promoter and repress transcription. Therefore, p107 and pRb regulate PGC-1alpha expression to control the switch between white and brown adipocyte differentiation from a common pool of presumptive adult progenitors in fat tissue.  (+info)

Assessment of brown adipose tissue activity in rats by 99mTc-sestamibi uptake. (2/644)

Brown adipose tissue (BAT) physiology and imaging have recently attracted considerable attention. BAT is characterized both by enhanced perfusion and increased mitochondrial activity. (99m)Tc-sestamibi is a lipophilic cationic tracer that concentrates in mitochondria. Data on the accumulation of (99m)Tc-sestamibi in BAT are currently lacking. This study investigates the in vivo (99m)Tc-sestamibi uptake in rat BAT. (99m)Tc-sestamibi was administered in male Wistar rats of various age and body size. (99m)Tc-sestamibi uptake was measured in vitro in BAT and white fat (WF) together with cytochrome c oxidase activity. Both (99m)Tc-sestamibi uptake and cytochrome c oxidase activity were higher in BAT than in WF (P<0.05). (99m)Tc-Sestamibi uptake in both BAT and WF was negatively related to body weight (r = -0.96 and -0.89, respectively) as was the BAT/WF uptake ratio (r = -0.85). These data show a higher (99m)Tc-sestamibi uptake in BAT compared to WF, in agreement with the high mitochondrial content and respiratory activity of the former. The strong negative correlation between (99m)Tc-sestamibi uptake in BAT and body weight (negative allometry), is in accordance to increased needs of thermogenesis in smaller animals. Implications of increased (99m)Tc-sestamibi uptake in BAT in radionuclide imaging are also discussed.  (+info)

Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. (3/644)

In human obesity, white adipose tissue (WAT) is enriched in macrophages. How macrophage infiltration in WAT contributes to the complications of obesity is unknown. This study tested the hypothesis that recruitment of macrophages in omental WAT is associated with hepatic damage in obese patients. Paired biopsies of subcutaneous and omental WAT and a liver biopsy were collected during gastric surgery in 46 obese women and 9 obese men (BMI 47.9 +/- 0.93 kg/m(2)). The number of HAM56+ macrophages in WAT was quantified microscopically, and correlations with clinical and biological parameters and histological liver pathology were investigated. There were twice as many macrophages in omental as in subcutaneous WAT (P<0.0001). After adjustment for age, omental WAT macrophage infiltration was correlated to fasting glucose and insulin, quantitative insulin sensitivity check index, triglycerides, aspartate aminotransferase (AST), and gamma-glutamyltranspeptidase. We propose an easy equation to estimate the amount of macrophages in omental WAT. Increased macrophage accumulation specifically in omental WAT was associated with hepatic fibroinflammatory lesions (P=0.01). The best predictive model for the severity of hepatic damage includes adiponectinemia, AST, and omental WAT macrophages. These data suggest that the presence of macrophages in omental WAT participates in the cellular mechanisms favoring hepatic fibroinflammatory lesions in obese patients.  (+info)

Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue. (4/644)

Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid. Many people supplement their diets with CLAs to attempt weight loss, and the trans-10,cis-12 isomer (t10,c12-CLA) of CLA reduces adiposity in animal models and humans. However, CLA treatment in mice causes insulin resistance that has been attributed to the lipoatrophic state, which is associated with hyperinsulinemia and hepatic steatosis. Here, we investigated the effect of t10,c12-CLA on adipose tissue inflammation, another factor promoting insulin resistance. We confirmed that t10,c12-CLA daily gavage performed in mice reduces white adipose tissue (WAT) mass and adiponectin and leptin serum levels and provokes hyperinsulinemia. In parallel, we demonstrated that this CLA isomer led to a rapid induction of inflammatory factors such as tumor necrosis factor-alpha and interleukin-6 gene expression in WAT without affecting their serum levels. In vitro, t10,c12-CLA directly induced IL-6 secretion in 3T3-L1 adipocytes by an nuclear factor-kappaB-dependent mechanism. In vivo, however, the lipoatrophic adipose tissue of CLA-treated mice was notable for a dramatic increase in macrophage infiltration and gene expression. Thus, CLA supplementation directly induces inflammatory gene expression in adipocytes and also promotes macrophage infiltration into adipose tissue to a local inflammatory state that contributes to insulin resistance.  (+info)

Trans-10, cis-12 conjugated linoleic acid causes inflammation and delipidation of white adipose tissue in mice: a microarray and histological analysis. (5/644)

A combined histological and microarray analysis of the white adipose tissue (WAT) of mice fed trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) was performed to better define functional responses. Mice fed t10c12 CLA for 14 days lost 85% of WAT mass, 95% of adipocyte lipid droplet volume, and 15 or 47% of the number of adipocytes and total cells, respectively. Microarray profiling of replicated pools (n = 2 per day x diet) of control and treated mice (n = 140) at seven time points after 1-17 days of t10c12 CLA feeding found between 2,682 and 4,216 transcript levels changed by twofold or more. Transcript levels for genes involved in glucose and fatty acid import or biosynthesis were significantly reduced. Highly expressed transcripts for lipases were significantly reduced but still abundant. Increased levels of mRNAs for two key thermogenesis proteins, uncoupling protein 1 and carnitine palmitoyltransferase 1, may have increased energy expenditures. Significant reductions of mRNAs for major adipocyte regulatory factors, including peroxisome proliferator activated receptor-gamma, sterol regulatory binding protein 1, CAAT/enhancer binding protein-alpha, and lipin 1 were correlated with the reduced transcript levels for key metabolic pathways in the WAT. A prolific inflammation response was indicated by the 2- to 100-fold induction of many cytokine transcripts, including those for IL-6, IL-1beta, TNF ligands, and CXC family members, and an increased density of macrophages. The mRNA changes suggest that a combination of cell loss, increased energy expenditure, and residual transport of lipids out of the adipocytes may account for the cumulative mass loss observed.  (+info)

White adipose tissue: storage and effector site for environmental pollutants. (6/644)

White adipose tissue (WAT) represents a reservoir of lipophilic environmental pollutants, especially of those which are resistant to biological and chemical degradation - so-called persistent organic pollutants (POPs). Large amounts of different congeners and isomers of these compounds exhibit a variety of adverse biological effects. Interactions among different classes of compounds, frequently with opposing effects, complicate hazard evaluation and risk assessment. WAT is the key organ for energy homeostasis and it also releases metabolites into the circulation and adipokines with systemic effects on insulin sensitivity and fuel partitioning in muscles and other tissues. Its beneficial role is lost in obesity when excessive accumulation of WAT contributes to severe diseases, such as diabetes. POPs may crossroad or modulate the effect of endogenous ligands of nuclear transcription factors, participating in differentiation, metabolism and the secretory function of adipocytes. These mechanisms include, most importantly: i) endocrine disrupting potency of POPs mixtures on androgen, estrogen or thyroid hormone metabolism/functions in WAT, ii) interference of dioxin-like chemicals with retinoic acid homeostasis, where impact on retinoid receptors is expected, and iii) interaction with transcriptional activity of peroxisome proliferator-activated receptors is likely. Thus, the accumulation and action of POPs in WAT represents a unitary mechanism explaining, at least in part, the effects of POPs in the whole organism. By modulating WAT differentiation, metabolism and function, the POPs could affect not only the physiological role of WAT, but they may also influence the development of obesity-associated diseases.  (+info)

Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease. (7/644)

AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and (1)H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs.  (+info)

Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats: implications for obesity treatment. (8/644)

Intense hyperleptinemia completely depletes adipocyte fat of normal rats within 14 days. To determine the mechanism, epididymal fat pads from normal wild-type (+/+) and obese (fa/fa) Zucker Diabetic Fatty (ZDF) donor rats were transplanted into normal +/+ and fa/fa ZDF recipients. Hyperleptinemia induced by adenovirus-leptin administration depleted all fat from native fat pads and from fat transplants from +/+ donors but not from transplants from ZDF(fa/fa) donors with defective leptin receptors. In both native and transplanted +/+ fat pads, large numbers of mitochondria were apparent, and genes involved in fatty acid oxidation were up-regulated. However, +/+ fat pads transplanted into fa/fa recipients did not respond to hyperleptinemia, suggesting lack of an essential leptin-stimulated cohormone(s). In +/+ but not in fa/fa rats, plasma catecholamine levels rose, and both P-STAT3 and P-CREB increased in adipose tissue, suggesting that both direct and indirect (hypothalamic) leptin receptor-mediated actions of hyperleptinemia are involved in depletion of adipocyte fat.  (+info)

There are several different types of obesity, including:

1. Central obesity: This type of obesity is characterized by excess fat around the waistline, which can increase the risk of health problems such as type 2 diabetes and cardiovascular disease.
2. Peripheral obesity: This type of obesity is characterized by excess fat in the hips, thighs, and arms.
3. Visceral obesity: This type of obesity is characterized by excess fat around the internal organs in the abdominal cavity.
4. Mixed obesity: This type of obesity is characterized by both central and peripheral obesity.

Obesity can be caused by a variety of factors, including genetics, lack of physical activity, poor diet, sleep deprivation, and certain medications. Treatment for obesity typically involves a combination of lifestyle changes, such as increased physical activity and a healthy diet, and in some cases, medication or surgery may be necessary to achieve weight loss.

Preventing obesity is important for overall health and well-being, and can be achieved through a variety of strategies, including:

1. Eating a healthy, balanced diet that is low in added sugars, saturated fats, and refined carbohydrates.
2. Engaging in regular physical activity, such as walking, jogging, or swimming.
3. Getting enough sleep each night.
4. Managing stress levels through relaxation techniques, such as meditation or deep breathing.
5. Avoiding excessive alcohol consumption and quitting smoking.
6. Monitoring weight and body mass index (BMI) on a regular basis to identify any changes or potential health risks.
7. Seeking professional help from a healthcare provider or registered dietitian for personalized guidance on weight management and healthy lifestyle choices.

There are several factors that can contribute to the development of insulin resistance, including:

1. Genetics: Insulin resistance can be inherited, and some people may be more prone to developing the condition based on their genetic makeup.
2. Obesity: Excess body fat, particularly around the abdominal area, can contribute to insulin resistance.
3. Physical inactivity: A sedentary lifestyle can lead to insulin resistance.
4. Poor diet: Consuming a diet high in refined carbohydrates and sugar can contribute to insulin resistance.
5. Other medical conditions: Certain medical conditions, such as polycystic ovary syndrome (PCOS) and Cushing's syndrome, can increase the risk of developing insulin resistance.
6. Medications: Certain medications, such as steroids and some antipsychotic drugs, can increase insulin resistance.
7. Hormonal imbalances: Hormonal changes during pregnancy or menopause can lead to insulin resistance.
8. Sleep apnea: Sleep apnea can contribute to insulin resistance.
9. Chronic stress: Chronic stress can lead to insulin resistance.
10. Aging: Insulin resistance tends to increase with age, particularly after the age of 45.

There are several ways to diagnose insulin resistance, including:

1. Fasting blood sugar test: This test measures the level of glucose in the blood after an overnight fast.
2. Glucose tolerance test: This test measures the body's ability to regulate blood sugar levels after consuming a sugary drink.
3. Insulin sensitivity test: This test measures the body's ability to respond to insulin.
4. Homeostatic model assessment (HOMA): This is a mathematical formula that uses the results of a fasting glucose and insulin test to estimate insulin resistance.
5. Adiponectin test: This test measures the level of adiponectin, a protein produced by fat cells that helps regulate blood sugar levels. Low levels of adiponectin are associated with insulin resistance.

There is no cure for insulin resistance, but it can be managed through lifestyle changes and medication. Lifestyle changes include:

1. Diet: A healthy diet that is low in processed carbohydrates and added sugars can help improve insulin sensitivity.
2. Exercise: Regular physical activity, such as aerobic exercise and strength training, can improve insulin sensitivity.
3. Weight loss: Losing weight, particularly around the abdominal area, can improve insulin sensitivity.
4. Stress management: Strategies to manage stress, such as meditation or yoga, can help improve insulin sensitivity.
5. Sleep: Getting adequate sleep is important for maintaining healthy insulin levels.

Medications that may be used to treat insulin resistance include:

1. Metformin: This is a commonly used medication to treat type 2 diabetes and improve insulin sensitivity.
2. Thiazolidinediones (TZDs): These medications, such as pioglitazone, improve insulin sensitivity by increasing the body's ability to use insulin.
3. Sulfonylureas: These medications stimulate the release of insulin from the pancreas, which can help improve insulin sensitivity.
4. DPP-4 inhibitors: These medications, such as sitagliptin, work by reducing the breakdown of the hormone incretin, which helps to increase insulin secretion and improve insulin sensitivity.
5. GLP-1 receptor agonists: These medications, such as exenatide, mimic the action of the hormone GLP-1 and help to improve insulin sensitivity.

It is important to note that these medications may have side effects, so it is important to discuss the potential benefits and risks with your healthcare provider before starting treatment. Additionally, lifestyle modifications such as diet and exercise can also be effective in improving insulin sensitivity and managing blood sugar levels.

Body weight is an important health indicator, as it can affect an individual's risk for certain medical conditions, such as obesity, diabetes, and cardiovascular disease. Maintaining a healthy body weight is essential for overall health and well-being, and there are many ways to do so, including a balanced diet, regular exercise, and other lifestyle changes.

There are several ways to measure body weight, including:

1. Scale: This is the most common method of measuring body weight, and it involves standing on a scale that displays the individual's weight in kg or lb.
2. Body fat calipers: These are used to measure body fat percentage by pinching the skin at specific points on the body.
3. Skinfold measurements: This method involves measuring the thickness of the skin folds at specific points on the body to estimate body fat percentage.
4. Bioelectrical impedance analysis (BIA): This is a non-invasive method that uses electrical impulses to measure body fat percentage.
5. Dual-energy X-ray absorptiometry (DXA): This is a more accurate method of measuring body composition, including bone density and body fat percentage.

It's important to note that body weight can fluctuate throughout the day due to factors such as water retention, so it's best to measure body weight at the same time each day for the most accurate results. Additionally, it's important to use a reliable scale or measuring tool to ensure accurate measurements.

Symptoms of panniculitis may include pain, swelling, redness, and warmth in the affected area. In severe cases, the skin may become ulcerated and the condition can be accompanied by systemic symptoms such as fever and fatigue.

Panniculitis is often difficult to diagnose, as it can resemble other conditions such as cellulitis or abscesses. A skin biopsy is usually necessary to confirm the diagnosis. Treatment typically involves antibiotics if the condition is caused by an infection, and drainage of any fluid accumulation if there is an abscess. In some cases, surgical debridement may be necessary.

While panniculitis is generally not a life-threatening condition, it can be painful and disruptive to daily activities. It is important to seek medical attention if symptoms persist or worsen over time, as the condition can lead to complications such as infection of the bloodstream (sepsis) or tissue death (necrosis).

Panniculitis can occur at any age but is more common in children and young adults. It is also more prevalent in certain populations such as those with obesity, diabetes, or other chronic conditions that affect the skin.

In summary, panniculitis is a type of inflammation of the subcutaneous fat layer that can be caused by various factors and can present with symptoms such as pain, swelling, redness, and warmth in the affected area. While generally not life-threatening, it can be painful and disruptive to daily activities, and prompt medical attention is necessary for proper diagnosis and treatment.

There are several key features of inflammation:

1. Increased blood flow: Blood vessels in the affected area dilate, allowing more blood to flow into the tissue and bringing with it immune cells, nutrients, and other signaling molecules.
2. Leukocyte migration: White blood cells, such as neutrophils and monocytes, migrate towards the site of inflammation in response to chemical signals.
3. Release of mediators: Inflammatory mediators, such as cytokines and chemokines, are released by immune cells and other cells in the affected tissue. These molecules help to coordinate the immune response and attract more immune cells to the site of inflammation.
4. Activation of immune cells: Immune cells, such as macrophages and T cells, become activated and start to phagocytose (engulf) pathogens or damaged tissue.
5. Increased heat production: Inflammation can cause an increase in metabolic activity in the affected tissue, leading to increased heat production.
6. Redness and swelling: Increased blood flow and leakiness of blood vessels can cause redness and swelling in the affected area.
7. Pain: Inflammation can cause pain through the activation of nociceptors (pain-sensing neurons) and the release of pro-inflammatory mediators.

Inflammation can be acute or chronic. Acute inflammation is a short-term response to injury or infection, which helps to resolve the issue quickly. Chronic inflammation is a long-term response that can cause ongoing damage and diseases such as arthritis, asthma, and cancer.

There are several types of inflammation, including:

1. Acute inflammation: A short-term response to injury or infection.
2. Chronic inflammation: A long-term response that can cause ongoing damage and diseases.
3. Autoimmune inflammation: An inappropriate immune response against the body's own tissues.
4. Allergic inflammation: An immune response to a harmless substance, such as pollen or dust mites.
5. Parasitic inflammation: An immune response to parasites, such as worms or fungi.
6. Bacterial inflammation: An immune response to bacteria.
7. Viral inflammation: An immune response to viruses.
8. Fungal inflammation: An immune response to fungi.

There are several ways to reduce inflammation, including:

1. Medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease-modifying anti-rheumatic drugs (DMARDs).
2. Lifestyle changes, such as a healthy diet, regular exercise, stress management, and getting enough sleep.
3. Alternative therapies, such as acupuncture, herbal supplements, and mind-body practices.
4. Addressing underlying conditions, such as hormonal imbalances, gut health issues, and chronic infections.
5. Using anti-inflammatory compounds found in certain foods, such as omega-3 fatty acids, turmeric, and ginger.

It's important to note that chronic inflammation can lead to a range of health problems, including:

1. Arthritis
2. Diabetes
3. Heart disease
4. Cancer
5. Alzheimer's disease
6. Parkinson's disease
7. Autoimmune disorders, such as lupus and rheumatoid arthritis.

Therefore, it's important to manage inflammation effectively to prevent these complications and improve overall health and well-being.

Lipodystrophy can be caused by genetic mutations, hormonal imbalances, or certain medications. It can also be associated with other medical conditions such as metabolic disorders, endocrine problems, and neurological diseases.

The symptoms of lipodystrophy can vary depending on the type and severity of the condition. Common symptoms include:

1. Muscle wasting and weakness
2. Fat redistribution to certain areas of the body (such as the face, neck, and torso)
3. Metabolic problems such as insulin resistance and high blood sugar
4. Hormonal imbalances
5. Abnormal body shape and proportions
6. Poor wound healing
7. Easy bruising and bleeding
8. Increased risk of infections
9. Joint pain and stiffness
10. Mood changes such as depression, anxiety, and irritability

Treatment for lipodystrophy depends on the underlying cause of the condition. Medications, lifestyle modifications, and surgery may be used to manage symptoms and improve quality of life. In some cases, lipodystrophy can be a sign of an underlying medical condition that needs to be treated.

Lipodystrophy can have a significant impact on an individual's quality of life, affecting their physical appearance, self-esteem, and ability to perform daily activities. It is important to seek medical attention if symptoms persist or worsen over time. With proper diagnosis and treatment, individuals with lipodystrophy can improve their symptoms and overall health.

In medicine, thinness is sometimes used as a diagnostic criterion for certain conditions, such as anorexia nervosa or cancer cachexia. In these cases, thinness can be a sign of a serious underlying condition that requires medical attention.

However, it's important to note that thinness alone is not enough to diagnose any medical condition. Other factors, such as a person's overall health, medical history, and physical examination findings, must also be taken into account when making a diagnosis. Additionally, it's important to recognize that being underweight or having a low BMI does not necessarily mean that someone is unhealthy or has a medical condition. Many people with a healthy weight and body composition can still experience negative health effects from societal pressure to be thin.

Overall, the concept of thinness in medicine is complex and multifaceted, and it's important for healthcare providers to consider all relevant factors when evaluating a patient's weight and overall health.

There are several different types of weight gain, including:

1. Clinical obesity: This is defined as a BMI of 30 or higher, and is typically associated with a range of serious health problems, such as heart disease, type 2 diabetes, and certain types of cancer.
2. Central obesity: This refers to excess fat around the waistline, which can increase the risk of health problems such as heart disease and type 2 diabetes.
3. Muscle gain: This occurs when an individual gains weight due to an increase in muscle mass, rather than fat. This type of weight gain is generally considered healthy and can improve overall fitness and athletic performance.
4. Fat gain: This occurs when an individual gains weight due to an increase in body fat, rather than muscle or bone density. Fat gain can increase the risk of health problems such as heart disease and type 2 diabetes.

Weight gain can be measured using a variety of methods, including:

1. Body mass index (BMI): This is a widely used measure of weight gain that compares an individual's weight to their height. A BMI of 18.5-24.9 is considered normal, while a BMI of 25-29.9 is considered overweight, and a BMI of 30 or higher is considered obese.
2. Waist circumference: This measures the distance around an individual's waistline and can be used to assess central obesity.
3. Skinfold measurements: These involve measuring the thickness of fat at specific points on the body, such as the abdomen or thighs.
4. Dual-energy X-ray absorptiometry (DXA): This is a non-invasive test that uses X-rays to measure bone density and body composition.
5. Bioelectrical impedance analysis (BIA): This is a non-invasive test that uses electrical impulses to measure body fat percentage and other physiological parameters.

Causes of weight gain:

1. Poor diet: Consuming high amounts of processed foods, sugar, and saturated fats can lead to weight gain.
2. Lack of physical activity: Engaging in regular exercise can help burn calories and maintain a healthy weight.
3. Genetics: An individual's genetic makeup can affect their metabolism and body composition, making them more prone to weight gain.
4. Hormonal imbalances: Imbalances in hormones such as insulin, thyroid, and cortisol can contribute to weight gain.
5. Medications: Certain medications, such as steroids and antidepressants, can cause weight gain as a side effect.
6. Sleep deprivation: Lack of sleep can disrupt hormones that regulate appetite and metabolism, leading to weight gain.
7. Stress: Chronic stress can lead to emotional eating and weight gain.
8. Age: Metabolism slows down with age, making it more difficult to maintain a healthy weight.
9. Medical conditions: Certain medical conditions such as hypothyroidism, Cushing's syndrome, and polycystic ovary syndrome (PCOS) can also contribute to weight gain.

Treatment options for obesity:

1. Lifestyle modifications: A combination of diet, exercise, and stress management techniques can help individuals achieve and maintain a healthy weight.
2. Medications: Prescription medications such as orlistat, phentermine-topiramate, and liraglutide can aid in weight loss.
3. Bariatric surgery: Surgical procedures such as gastric bypass surgery and sleeve gastrectomy can be effective for severe obesity.
4. Behavioral therapy: Cognitive-behavioral therapy (CBT) and other forms of counseling can help individuals develop healthy eating habits and improve their physical activity levels.
5. Meal replacement plans: Meal replacement plans such as Medifast can provide individuals with a structured diet that is high in protein, fiber, and vitamins, and low in calories and sugar.
6. Weight loss supplements: Supplements such as green tea extract, garcinia cambogia, and forskolin can help boost weight loss efforts.
7. Portion control: Using smaller plates and measuring cups can help individuals regulate their portion sizes and maintain a healthy weight.
8. Mindful eating: Paying attention to hunger and fullness cues, eating slowly, and savoring food can help individuals develop healthy eating habits.
9. Physical activity: Engaging in regular physical activity such as walking, running, swimming, or cycling can help individuals burn calories and maintain a healthy weight.

It's important to note that there is no one-size-fits-all approach to treating obesity, and the most effective treatment plan will depend on the individual's specific needs and circumstances. Consulting with a healthcare professional such as a registered dietitian or a physician can help individuals develop a personalized treatment plan that is safe and effective.

There are two main types of fatty liver disease:

1. Alcoholic fatty liver disease (AFLD): This type of fatty liver disease is caused by excessive alcohol consumption and is the most common cause of fatty liver disease in the United States.
2. Non-alcoholic fatty liver disease (NAFLD): This type of fatty liver disease is not caused by alcohol consumption and is the most common cause of fatty liver disease worldwide. It is often associated with obesity, diabetes, and high cholesterol.

There are several risk factors for developing fatty liver disease, including:

* Obesity
* Physical inactivity
* High calorie intake
* Alcohol consumption
* Diabetes
* High cholesterol
* High triglycerides
* History of liver disease

Symptoms of fatty liver disease can include:

* Fatigue
* Abdominal discomfort
* Loss of appetite
* Nausea and vomiting
* Abnormal liver function tests

Diagnosis of fatty liver disease is typically made through a combination of physical examination, medical history, and diagnostic tests such as:

* Liver biopsy
* Imaging studies (ultrasound, CT or MRI scans)
* Blood tests (lipid profile, glucose, insulin, and liver function tests)

Treatment of fatty liver disease depends on the underlying cause and severity of the condition. Lifestyle modifications such as weight loss, exercise, and a healthy diet can help improve the condition. In severe cases, medications such as antioxidants, fibric acids, and anti-inflammatory drugs may be prescribed. In some cases, surgery or other procedures may be necessary.

Prevention of fatty liver disease includes:

* Maintaining a healthy weight
* Eating a balanced diet low in sugar and saturated fats
* Engaging in regular physical activity
* Limiting alcohol consumption
* Managing underlying medical conditions such as diabetes and high cholesterol.

Morbid obesity is typically defined as a BMI of 40 or higher, but some experts define it as a BMI of 35 or higher with one or more obesity-related health conditions, such as high blood pressure, type 2 diabetes, or sleep apnea.

Morbid obesity is different from simple obesity, which is defined as a BMI of 30 to 39. While simple obesity can also increase the risk of health problems, it is generally considered less severe than morbid obesity.

Morbid obesity is often treated with a combination of lifestyle changes, such as diet and exercise, and medications or surgery. In some cases, bariatric surgery may be recommended to help achieve and maintain weight loss.

It is important to note that BMI is not always an accurate measure of health, as it does not take into account muscle mass or body composition. However, it can provide a general indicator of whether an individual is at a healthy weight or if they are at risk for health problems due to their weight.

There are several types of adipocytic neoplasms, including:

1. Lipomas: These are benign, slow-growing tumors that are composed of mature fat cells (adipocytes). They are usually soft to the touch and can be moved easily under the skin.
2. Liposarcomas: These are malignant tumors that also originate in adipose tissue. They can be slow-growing or aggressive and can infiltrate surrounding tissues.
3. Pigmented villonodular synovitis (PVN): This is a type of benign tumor that occurs in the synovial membrane, which lines the joints and tendons. It is composed of adipocytes and other cell types and can cause pain and stiffness in the affected joint.
4. Giant cell lipomatosis: This is a rare condition characterized by multiple small lipomas that are clustered together.
5. Spindle cell lipoma: This is a rare type of lipoma that contains spindle-shaped cells, which are elongated and irregular in shape.

These adipocytic neoplasms can be diagnosed through various imaging techniques such as ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI), and fine needle aspiration biopsy. Treatment options vary depending on the type and location of the tumor, but may include surgical excision, radiation therapy, or chemotherapy.

There are many different approaches to weight loss, and what works best for one person may not work for another. Some common strategies for weight loss include:

* Caloric restriction: Reducing daily caloric intake to create a calorie deficit that promotes weight loss.
* Portion control: Eating smaller amounts of food and avoiding overeating.
* Increased physical activity: Engaging in regular exercise, such as walking, running, swimming, or weightlifting, to burn more calories and build muscle mass.
* Behavioral modifications: Changing habits and behaviors related to eating and exercise, such as keeping a food diary or enlisting the support of a weight loss buddy.

Weight loss can have numerous health benefits, including:

* Improved blood sugar control
* Reduced risk of heart disease and stroke
* Lowered blood pressure
* Improved joint health and reduced risk of osteoarthritis
* Improved sleep quality
* Boosted mood and reduced stress levels
* Increased energy levels

However, weight loss can also be challenging, and it is important to approach it in a healthy and sustainable way. Crash diets and other extreme weight loss methods are not effective in the long term and can lead to nutrient deficiencies and other negative health consequences. Instead, it is important to focus on making sustainable lifestyle changes that can be maintained over time.

Some common misconceptions about weight loss include:

* All weight loss methods are effective for everyone.
* Weight loss should always be the primary goal of a fitness or health program.
* Crash diets and other extreme weight loss methods are a good way to lose weight quickly.
* Weight loss supplements and fad diets are a reliable way to achieve significant weight loss.

The most effective ways to lose weight and maintain weight loss include:

* Eating a healthy, balanced diet that is high in nutrient-dense foods such as fruits, vegetables, whole grains, lean proteins, and healthy fats.
* Engaging in regular physical activity, such as walking, running, swimming, or weight training.
* Getting enough sleep and managing stress levels.
* Aiming for a gradual weight loss of 1-2 pounds per week.
* Focusing on overall health and wellness rather than just the number on the scale.

It is important to remember that weight loss is not always linear and can vary from week to week. It is also important to be patient and consistent with your weight loss efforts, as it can take time to see significant results.

Overall, weight loss can be a challenging but rewarding process, and it is important to approach it in a healthy and sustainable way. By focusing on overall health and wellness rather than just the number on the scale, you can achieve a healthy weight and improve your overall quality of life.

Type 2 diabetes can be managed through a combination of diet, exercise, and medication. In some cases, lifestyle changes may be enough to control blood sugar levels, while in other cases, medication or insulin therapy may be necessary. Regular monitoring of blood sugar levels and follow-up with a healthcare provider are important for managing the condition and preventing complications.

Common symptoms of type 2 diabetes include:

* Increased thirst and urination
* Fatigue
* Blurred vision
* Cuts or bruises that are slow to heal
* Tingling or numbness in the hands and feet
* Recurring skin, gum, or bladder infections

If left untreated, type 2 diabetes can lead to a range of complications, including:

* Heart disease and stroke
* Kidney damage and failure
* Nerve damage and pain
* Eye damage and blindness
* Foot damage and amputation

The exact cause of type 2 diabetes is not known, but it is believed to be linked to a combination of genetic and lifestyle factors, such as:

* Obesity and excess body weight
* Lack of physical activity
* Poor diet and nutrition
* Age and family history
* Certain ethnicities (e.g., African American, Hispanic/Latino, Native American)
* History of gestational diabetes or delivering a baby over 9 lbs.

There is no cure for type 2 diabetes, but it can be managed and controlled through a combination of lifestyle changes and medication. With proper treatment and self-care, people with type 2 diabetes can lead long, healthy lives.

Starvation is a condition where an individual's body does not receive enough nutrients to maintain proper bodily functions and growth. It can be caused by a lack of access to food, poverty, poor nutrition, or other factors that prevent the intake of sufficient calories and essential nutrients. Starvation can lead to severe health consequences, including weight loss, weakness, fatigue, and even death.

Types of Starvation:

There are several types of starvation, each with different causes and effects. These include:

1. Acute starvation: This occurs when an individual suddenly stops eating or has a limited access to food for a short period of time.
2. Chronic starvation: This occurs when an individual consistently does not consume enough calories and nutrients over a longer period of time, leading to gradual weight loss and other health problems.
3. Malnutrition starvation: This occurs when an individual's diet is deficient in essential nutrients, leading to malnutrition and other health problems.
4. Marasmus: This is a severe form of starvation that occurs in children, characterized by extreme weight loss, weakness, and wasting of muscles and organs.
5. Kwashiorkor: This is a form of malnutrition caused by a diet lacking in protein, leading to edema, diarrhea, and other health problems.

Effects of Starvation on the Body:

Starvation can have severe effects on the body, including:

1. Weight loss: Starvation causes weight loss, which can lead to a decrease in muscle mass and a loss of essential nutrients.
2. Fatigue: Starvation can cause fatigue, weakness, and a lack of energy, making it difficult to perform daily activities.
3. Weakened immune system: Starvation can weaken the immune system, making an individual more susceptible to illnesses and infections.
4. Nutrient deficiencies: Starvation can lead to a deficiency of essential nutrients, including vitamins and minerals, which can cause a range of health problems.
5. Increased risk of disease: Starvation can increase the risk of diseases such as tuberculosis, pellagra, and other infections.
6. Mental health issues: Starvation can lead to mental health issues such as depression, anxiety, and irritability.
7. Reproductive problems: Starvation can cause reproductive problems, including infertility and miscarriage.
8. Hair loss: Starvation can cause hair loss, which can be a sign of malnutrition.
9. Skin problems: Starvation can cause skin problems, such as dryness, irritation, and infections.
10. Increased risk of death: Starvation can lead to increased risk of death, especially in children and the elderly.

It is important to note that these effects can be reversed with proper nutrition and care. If you or someone you know is experiencing starvation, it is essential to seek medical attention immediately.

These diseases can cause a wide range of symptoms such as fatigue, weight changes, and poor wound healing. Treatment options vary depending on the specific condition but may include lifestyle changes, medications, or surgery.

1. Impaired glucose tolerance (IGT): This is a condition where the body has difficulty regulating blood sugar levels after consuming a meal.
2. Impaired fasting glucose (IFG): This is a condition where the body has difficulty regulating blood sugar levels when fasting (not eating for a period of time).
3. Gestational diabetes: This is a type of diabetes that develops during pregnancy, usually in the second or third trimester.
4. Type 2 diabetes: This is a chronic condition where the body cannot effectively use insulin to regulate blood sugar levels.

The symptoms of glucose intolerance can vary depending on the type and severity of the condition. Some common symptoms include:

* High blood sugar levels
* Increased thirst and urination
* Fatigue
* Blurred vision
* Cuts or bruises that are slow to heal
* Tingling or numbness in the hands and feet

The diagnosis of glucose intolerance is typically made through a combination of physical examination, medical history, and laboratory tests such as:

* Fasting plasma glucose (FPG) test: This measures the level of glucose in the blood after an overnight fast.
* Oral glucose tolerance test (OGTT): This measures the body's ability to regulate blood sugar levels after consuming a sugary drink.
* Hemoglobin A1c (HbA1c) test: This measures the average blood sugar level over the past 2-3 months.

Treatment for glucose intolerance usually involves lifestyle changes such as:

* Eating a healthy, balanced diet that is low in added sugars and refined carbohydrates
* Increasing physical activity to help the body use insulin more effectively
* Losing weight if you are overweight or obese
* Monitoring blood sugar levels regularly

In some cases, medication may be prescribed to help manage blood sugar levels. These include:

* Metformin: This is a type of oral medication that helps the body use insulin more effectively.
* Sulfonylureas: These medications stimulate the release of insulin from the pancreas.
* Thiazolidinediones: These medications improve the body's sensitivity to insulin.

If left untreated, glucose intolerance can lead to a range of complications such as:

* Type 2 diabetes: This is a more severe form of glucose intolerance that can cause damage to the body's organs and tissues.
* Cardiovascular disease: High blood sugar levels can increase the risk of heart disease and stroke.
* Nerve damage: High blood sugar levels over an extended period can damage the nerves, leading to numbness, tingling, and pain in the hands and feet.
* Kidney damage: High blood sugar levels can damage the kidneys and lead to kidney disease.
* Eye damage: High blood sugar levels can damage the blood vessels in the eyes, leading to vision problems.

It is important to note that not everyone with glucose intolerance will develop these complications, but it is important to manage the condition to reduce the risk of these complications occurring.

While lipomatosis is not a life-threatening condition, it can cause discomfort and pain due to the size and location of the lipomas. In some cases, lipomatosis may also lead to other health problems, such as obesity, joint pain, and sleep apnea.

There are several risk factors for developing lipomatosis, including:

* Genetics: Lipomatosis can be inherited from one's parents.
* Obesity: Excess weight is a major risk factor for developing lipomatosis.
* Hormonal changes: Changes in hormone levels, such as those that occur during pregnancy or menopause, can increase the risk of developing lipomatosis.
* Age: Lipomatosis is more common in adults over the age of 40.
* Gender: Women are more likely to develop lipomatosis than men.

There are several treatment options for lipomatosis, including:

* Liposuction: A surgical procedure that removes excess fat cells.
* Medications: Certain medications, such as corticosteroids and antidepressants, can help reduce the size of lipomas.
* Diet and exercise: Maintaining a healthy diet and exercise routine can help reduce body weight and alleviate symptoms of lipomatosis.

It is important to note that while lipomatosis is not a life-threatening condition, it can have a significant impact on a person's quality of life. If you suspect you may be experiencing symptoms of lipomatosis, it is important to consult with a healthcare professional for proper diagnosis and treatment.

1. Abdominal obesity (excess fat around the waistline)
2. High blood pressure (hypertension)
3. Elevated fasting glucose (high blood sugar)
4. High serum triglycerides (elevated levels of triglycerides in the blood)
5. Low HDL cholesterol (low levels of "good" cholesterol)

Having three or more of these conditions is considered a diagnosis of metabolic syndrome X. It is estimated that approximately 34% of adults in the United States have this syndrome, and it is more common in women than men. Risk factors for developing metabolic syndrome include obesity, lack of physical activity, poor diet, and a family history of type 2 diabetes or CVD.

The term "metabolic syndrome" was first introduced in the medical literature in the late 1980s, and since then, it has been the subject of extensive research. The exact causes of metabolic syndrome are not yet fully understood, but it is believed to be related to insulin resistance, inflammation, and changes in body fat distribution.

Treatment for metabolic syndrome typically involves lifestyle modifications such as weight loss, regular physical activity, and a healthy diet. Medications such as blood pressure-lowering drugs, cholesterol-lowering drugs, and anti-diabetic medications may also be prescribed if necessary. It is important to note that not everyone with metabolic syndrome will develop type 2 diabetes or CVD, but the risk is increased. Therefore, early detection and treatment are crucial in preventing these complications.

HALS typically involves the accumulation of fat in the face, neck, and torso, while the arms and legs become thin and wasted. This can lead to a characteristic "buffalo hump" appearance on the back of the neck and a "spare tire" around the waist. In addition to the cosmetic changes, HALS can also cause metabolic problems such as insulin resistance, high blood sugar, and high levels of lipids (fats) in the blood.

HIV-associated lipodystrophy syndrome is thought to be caused by a combination of factors, including genetics, hormonal imbalances, and side effects of certain HIV medications. Treatment for HALS typically involves a multidisciplinary approach, including lifestyle modifications such as diet and exercise, as well as medication therapy to manage metabolic abnormalities and reduce the risk of cardiovascular disease.

HIV-associated lipodystrophy syndrome is a significant health concern for individuals living with HIV, as it can increase the risk of other serious health problems such as heart disease and stroke. It is important for individuals infected with HIV to be aware of the risk of developing HALS and to work closely with their healthcare provider to manage this condition effectively.

There are many types of lipoma, with different names depending on their location and the tissues in which they grow. Common types include:

-Intramuscular lipoma: These occur within muscles and can feel firm or hard to the touch.

-Subcutaneous lipoma: These grow just beneath the skin and are usually soft to the touch.

-Mixed lipoma: These contain both fat cells and other types of tissue, such as muscle fibers.

-Spindle cell lipoma: These lipomas have a characteristic spindle or cylindrical shape under a microscope.

There are several ways to diagnose a lipoma, including physical examination, ultrasound imaging, and biopsy. Treatment for lipoma usually involves monitoring the tumor over time, as it will likely shrink or stay the same size without any intervention. However, if a lipoma grows quickly, becomes painful, or is causing discomfort or functional problems, surgical removal may be necessary.

In conclusion, lipomas are noncancerous growths that occur just beneath the skin or within muscles and connective tissues. They are usually painless unless pressed, but they can still cause discomfort or functional problems if large enough. While surgery is sometimes required to remove a lipoma, it is usually not necessary as long as the tumor remains small and doesn't grow rapidly over time.

In hyperinsulinism, the body produces too much insulin, leading to a range of symptoms including:

1. Hypoglycemia (low blood sugar): Excessive insulin can cause blood sugar levels to drop too low, leading to hypoglycemic symptoms such as shakiness, dizziness, confusion, and rapid heartbeat.
2. Weight gain: Hyperinsulinism can lead to weight gain due to the body's inability to effectively use glucose for energy production.
3. Fatigue: Excessive insulin can cause fatigue, as the body's cells are not able to effectively use glucose for energy production.
4. Mood changes: Hyperinsulinism can lead to mood changes such as irritability, anxiety, and depression.
5. Polycystic ovary syndrome (PCOS): Women with PCOS are at a higher risk of developing hyperinsulinism due to insulin resistance.
6. Gestational diabetes: Hyperinsulinism can occur during pregnancy, leading to gestational diabetes.
7. Acanthosis nigricans: A condition characterized by dark, velvety patches on the skin, often found in the armpits, neck, and groin area.
8. Cancer: Hyperinsulinism has been linked to an increased risk of certain types of cancer, such as breast, colon, and pancreatic cancer.
9. Cardiovascular disease: Excessive insulin can increase the risk of cardiovascular disease, including high blood pressure, heart disease, and stroke.
10. Cognitive impairment: Hyperinsulinism has been linked to cognitive impairment and an increased risk of dementia.

There are several causes of hyperinsulinism, including:

1. Insulin-producing tumors: Tumors that produce excessive amounts of insulin can lead to hyperinsulinism.
2. Familial hyperinsulinism: A genetic disorder that affects the regulation of insulin secretion and action.
3. Pancreatic beta-cell dysfunction: Dysfunction in the pancreatic beta cells, which produce insulin, can lead to hyperinsulinism.
4. Medications: Certain medications such as steroids and certain psychiatric drugs can cause hyperinsulinism.
5. Pituitary tumors: Tumors in the pituitary gland can lead to excessive secretion of growth hormone, which can stimulate insulin production.
6. Maternal diabetes during pregnancy: Women with diabetes during pregnancy may experience hyperinsulinism due to increased insulin resistance and higher insulin levels.
7. Gestational diabetes: High blood sugar during pregnancy can lead to hyperinsulinism.
8. Polycystic ovary syndrome (PCOS): Women with PCOS may experience hyperinsulinism due to insulin resistance and high insulin levels.
9. Cushing's syndrome: An endocrine disorder caused by excessive cortisol production can lead to hyperinsulinism.
10. Other medical conditions: Certain medical conditions such as thyroid disorders, adrenal gland disorders, and pituitary gland disorders can also cause hyperinsulinism.

It's important to note that some individuals with hyperinsulinism may not experience any symptoms, while others may experience a range of symptoms, including:

1. Weight gain
2. Fatigue
3. Headaches
4. Numbness or tingling in the hands and feet
5. Memory loss and difficulty concentrating
6. Mood changes, such as anxiety and depression
7. Skin problems, such as acne and thinning skin
8. Increased risk of heart disease and stroke
9. Growth retardation in children
10. Increased risk of developing type 2 diabetes

If you suspect that you or your child may have hyperinsulinism, it's important to consult with a healthcare professional for proper diagnosis and treatment. A doctor may perform a physical examination, take a medical history, and order blood tests to determine if hyperinsulinism is present and what may be causing it. Treatment options for hyperinsulinism will depend on the underlying cause of the condition. In some cases, medications such as metformin or other anti-diabetic drugs may be prescribed to help regulate blood sugar levels and reduce insulin production. In other cases, surgery or lifestyle changes may be necessary. With proper diagnosis and treatment, it is possible to manage hyperinsulinism and prevent or manage related health complications.

1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.

2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.

3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.

4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.

5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.

6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.

7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.

8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.

9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.

10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.

The term "lipodystrophy" refers to a group of conditions in which there is a loss or abnormal distribution of fat cells. Congenital generalized lipodystrophy is the most severe form of lipodystrophy and is usually diagnosed at birth or soon after.

The symptoms of CGL can vary depending on the severity of the condition, but may include:

1. Poor muscle tone (hypotonia)
2. Delayed development of motor skills
3. Fatigue and weakness
4. Poor appetite and growth delay
5. Abnormal fat distribution in the body
6. Metabolic problems, such as high blood sugar and insulin resistance
7. Increased risk of infections and other complications.

CGL is caused by mutations in genes that are important for adipose tissue development and function. There is currently no cure for CGL, but treatment may involve a combination of medication, nutritional support, and lifestyle modifications to manage the associated symptoms and complications.

The prognosis for individuals with CGL can vary depending on the severity of the condition and the presence of any additional health problems. However, with appropriate medical care and support, many individuals with CGL are able to lead active and fulfilling lives.

The exact cause of lipoatrophic diabetes mellitus is not fully understood, but it is believed to be related to an autoimmune response, where the body's immune system mistakenly attacks the insulin-producing cells in the pancreas. The condition is more common in males than females and typically affects adults between the ages of 20 and 40.

The diagnosis of lipoatrophic diabetes mellitus is based on a combination of clinical findings, laboratory tests, and imaging studies. Laboratory tests may include measurements of blood sugar levels, insulin levels, and antibodies against insulin or pancreatic cells. Imaging studies, such as CT scans or MRI scans, may be used to evaluate the pancreas and identify any damage to the insulin-producing cells.

Treatment of lipoatrophic diabetes mellitus typically involves a combination of insulin replacement therapy and lifestyle modifications such as a healthy diet and regular exercise. In some cases, medications such as metformin or sulfonylureas may be used to help improve insulin sensitivity. Regular monitoring of blood sugar levels and follow-up with a healthcare provider are also important to prevent complications associated with the condition.

In summary, lipoatrophic diabetes mellitus is a rare form of diabetes that is characterized by an insulin deficiency caused by the destruction of insulin-producing cells in the pancreas. The exact cause of the condition is not fully understood, but it is believed to be related to an autoimmune response. Treatment typically involves a combination of insulin replacement therapy and lifestyle modifications, and regular monitoring of blood sugar levels is important to prevent complications associated with the condition.

The exact cause of cachexia is not fully understood, but it is thought to be related to a combination of factors such as inflammation, hormonal imbalances, and changes in metabolism. Treatment for cachexia often focuses on addressing the underlying cause of the wasting, such as managing cancer or HIV/AIDS, as well as providing nutritional support and addressing any related complications.

In the medical field, cachexia is a serious condition that requires careful management to improve quality of life and outcomes for patients. It is important for healthcare providers to be aware of the signs and symptoms of cachexia and to provide appropriate treatment and support to affected individuals.

There are several ways to measure abdominal obesity, including:

1. Waist circumference: Measured by circling the natural waistline with a tape measure. Excess fat around the waistline is defined as a circumference of 35 inches or more for women and 40 inches or more for men.
2. Waist-to-hip ratio: Measured by dividing the circumference of the natural waistline by the circumference of the hips. A ratio of 0.8 or higher indicates abdominal obesity.
3. Body fat distribution: Measured using techniques such as dual-energy X-ray absorptiometry (DXA) or bioelectrical impedance analysis (BIA). These methods can estimate the amount of fat in various areas of the body, including the abdomen.

There are several factors that contribute to the development of abdominal obesity, including:

1. Genetics: Inheritance plays a role in the distribution of body fat, with some people more prone to accumulating fat around the midsection.
2. Poor diet: Consuming high amounts of processed foods, sugar, and saturated fats can contribute to weight gain and abdominal obesity.
3. Lack of physical activity: Sedentary lifestyle can lead to a decrease in muscle mass and an increase in body fat, including around the abdomen.
4. Age: As people age, their metabolism slows down, leading to weight gain and increased risk of obesity.
5. Hormonal imbalances: Certain hormonal imbalances, such as hypothyroidism or polycystic ovary syndrome (PCOS), can increase the risk of developing abdominal obesity.

Abdominal obesity is a significant health risk due to its association with various chronic diseases, including:

1. Type 2 diabetes: Excess fat around the abdominal area can lead to insulin resistance and increase the risk of developing type 2 diabetes.
2. Cardiovascular disease: Abdominal obesity is a major risk factor for heart disease, as excess fat in this area can increase the risk of high blood pressure, high cholesterol, and triglycerides.
3. Cancer: Studies have shown that central obesity is associated with an increased risk of certain types of cancer, including colon, breast, and pancreatic cancer.
4. Non-alcoholic fatty liver disease (NAFLD): Abdominal obesity can lead to the development of NAFLD, a condition characterized by fat accumulation in the liver, which can increase the risk of liver damage and other health complications.
5. Sleep apnea: Excess fat around the abdomen can increase the risk of sleep apnea, a condition characterized by pauses in breathing during sleep.
6. Respiratory problems: Abdominal obesity can increase the risk of respiratory problems, such as asthma and chronic obstructive pulmonary disease (COPD).
7. Osteoarthritis: Excess weight, particularly around the abdomen, can increase the risk of osteoarthritis in the knees and hips.
8. Mental health: Central obesity has been linked to an increased risk of depression and other mental health conditions.
9. Fertility problems: Abdominal obesity can affect fertility in both men and women, as excess fat can disrupt hormone levels and reduce the likelihood of conception.
10. Reduced life expectancy: Abdominal obesity is associated with a shorter life expectancy, as it increases the risk of various chronic diseases that can reduce lifespan.

Steatitis can cause a range of symptoms, including:

* Pain and tenderness in the affected area
* Swelling and redness
* Warmth to the touch
* Limited mobility or stiffness in the affected joint
* Fever

The exact cause of steatitis is not always clear, but it is thought to be related to changes in the body's metabolism and insulin resistance. In some cases, steatitis may be a side effect of certain medications or medical conditions, such as corticosteroid use or Cushing's syndrome.

There are several methods for diagnosing steatitis, including:

* Physical examination and medical history
* Imaging tests, such as X-rays or MRI scans
* Blood tests, such as lipase and amylase enzyme levels

Treatment for steatitis typically focuses on addressing the underlying cause of the condition. This may involve lifestyle changes, such as weight loss and exercise, as well as medication to manage related conditions like diabetes or high blood pressure. In some cases, surgery may be necessary to remove affected fat tissue.

In conclusion, steatitis is a condition characterized by inflammation of fat tissue that can cause pain, swelling, and limited mobility. It is often associated with obesity and metabolic disorders, and can be diagnosed through physical examination, imaging tests, and blood tests. Treatment typically focuses on addressing the underlying cause of the condition.

There are several types of hypertrophy, including:

1. Muscle hypertrophy: The enlargement of muscle fibers due to increased protein synthesis and cell growth, often seen in individuals who engage in resistance training exercises.
2. Cardiac hypertrophy: The enlargement of the heart due to an increase in cardiac workload, often seen in individuals with high blood pressure or other cardiovascular conditions.
3. Adipose tissue hypertrophy: The excessive growth of fat cells, often seen in individuals who are obese or have insulin resistance.
4. Neurological hypertrophy: The enlargement of neural structures such as brain or spinal cord due to an increase in the number of neurons or glial cells, often seen in individuals with neurodegenerative diseases such as Alzheimer's or Parkinson's.
5. Hepatic hypertrophy: The enlargement of the liver due to an increase in the number of liver cells, often seen in individuals with liver disease or cirrhosis.
6. Renal hypertrophy: The enlargement of the kidneys due to an increase in blood flow and filtration, often seen in individuals with kidney disease or hypertension.
7. Ovarian hypertrophy: The enlargement of the ovaries due to an increase in the number of follicles or hormonal imbalances, often seen in individuals with polycystic ovary syndrome (PCOS).

Hypertrophy can be diagnosed through various medical tests such as imaging studies (e.g., CT scans, MRI), biopsies, and blood tests. Treatment options for hypertrophy depend on the underlying cause and may include medications, lifestyle changes, and surgery.

In conclusion, hypertrophy is a growth or enlargement of cells, tissues, or organs in response to an excessive stimulus. It can occur in various parts of the body, including the brain, liver, kidneys, heart, muscles, and ovaries. Understanding the underlying causes and diagnosis of hypertrophy is crucial for effective treatment and management of related health conditions.

Types of Experimental Diabetes Mellitus include:

1. Streptozotocin-induced diabetes: This type of EDM is caused by administration of streptozotocin, a chemical that damages the insulin-producing beta cells in the pancreas, leading to high blood sugar levels.
2. Alloxan-induced diabetes: This type of EDM is caused by administration of alloxan, a chemical that also damages the insulin-producing beta cells in the pancreas.
3. Pancreatectomy-induced diabetes: In this type of EDM, the pancreas is surgically removed or damaged, leading to loss of insulin production and high blood sugar levels.

Experimental Diabetes Mellitus has several applications in research, including:

1. Testing new drugs and therapies for diabetes treatment: EDM allows researchers to evaluate the effectiveness of new treatments on blood sugar control and other physiological processes.
2. Studying the pathophysiology of diabetes: By inducing EDM in animals, researchers can study the progression of diabetes and its effects on various organs and tissues.
3. Investigating the role of genetics in diabetes: Researchers can use EDM to study the effects of genetic mutations on diabetes development and progression.
4. Evaluating the efficacy of new diagnostic techniques: EDM allows researchers to test new methods for diagnosing diabetes and monitoring blood sugar levels.
5. Investigating the complications of diabetes: By inducing EDM in animals, researchers can study the development of complications such as retinopathy, nephropathy, and cardiovascular disease.

In conclusion, Experimental Diabetes Mellitus is a valuable tool for researchers studying diabetes and its complications. The technique allows for precise control over blood sugar levels and has numerous applications in testing new treatments, studying the pathophysiology of diabetes, investigating the role of genetics, evaluating new diagnostic techniques, and investigating complications.

There are several types of diabetes mellitus, including:

1. Type 1 DM: This is an autoimmune condition in which the body's immune system attacks and destroys the cells in the pancreas that produce insulin, resulting in a complete deficiency of insulin production. It typically develops in childhood or adolescence, and patients with this condition require lifelong insulin therapy.
2. Type 2 DM: This is the most common form of diabetes, accounting for around 90% of all cases. It is caused by a combination of insulin resistance (where the body's cells do not respond properly to insulin) and impaired insulin secretion. It is often associated with obesity, physical inactivity, and a diet high in sugar and unhealthy fats.
3. Gestational DM: This type of diabetes develops during pregnancy, usually in the second or third trimester. Hormonal changes and insulin resistance can cause blood sugar levels to rise, putting both the mother and baby at risk.
4. LADA (Latent Autoimmune Diabetes in Adults): This is a form of type 1 DM that develops in adults, typically after the age of 30. It shares features with both type 1 and type 2 DM.
5. MODY (Maturity-Onset Diabetes of the Young): This is a rare form of diabetes caused by genetic mutations that affect insulin production. It typically develops in young adulthood and can be managed with lifestyle changes and/or medication.

The symptoms of diabetes mellitus can vary depending on the severity of the condition, but may include:

1. Increased thirst and urination
2. Fatigue
3. Blurred vision
4. Cuts or bruises that are slow to heal
5. Tingling or numbness in hands and feet
6. Recurring skin, gum, or bladder infections
7. Flu-like symptoms such as weakness, dizziness, and stomach pain
8. Dark, velvety skin patches (acanthosis nigricans)
9. Yellowish color of the skin and eyes (jaundice)
10. Delayed healing of cuts and wounds

If left untreated, diabetes mellitus can lead to a range of complications, including:

1. Heart disease and stroke
2. Kidney damage and failure
3. Nerve damage (neuropathy)
4. Eye damage (retinopathy)
5. Foot damage (neuropathic ulcers)
6. Cognitive impairment and dementia
7. Increased risk of infections and other diseases, such as pneumonia, gum disease, and urinary tract infections.

It is important to note that not all individuals with diabetes will experience these complications, and that proper management of the condition can greatly reduce the risk of developing these complications.

Definition: Hyperphagia is a condition characterized by excessive hunger and overeating, often seen in individuals with certain medical or psychiatric conditions.

More Information

Hyperphagia can be caused by a variety of factors, including:

* Hormonal imbalances, such as low levels of leptin or high levels of ghrelin
* Certain medications, such as steroids and some antidepressants
* Medical conditions, such as diabetes, hypothyroidism, and polycystic ovary syndrome (PCOS)
* Psychiatric conditions, such as binge eating disorder and other eating disorders
* Sleep deprivation or disruptions in the body's circadian rhythms

Symptoms of hyperphagia may include:

* Increased hunger and desire to eat
* Overeating or consuming large amounts of food
* Difficulty controlling food intake
* Feeling anxious or irritable when unable to eat
* Weight gain or obesity

Treatment for hyperphagia typically involves addressing the underlying cause, such as hormonal imbalances or psychiatric conditions. This may involve medication, therapy, or lifestyle changes. In some cases, weight loss strategies and nutrition counseling may also be helpful.

It is important to note that hyperphagia can have serious health consequences, including obesity, type 2 diabetes, and other metabolic disorders. If you suspect you or someone you know may be experiencing hyperphagia, it is important to seek medical attention to determine the cause and develop an appropriate treatment plan.

Being overweight can increase the risk of various health problems, such as heart disease, type 2 diabetes, high blood pressure, and certain types of cancer. It can also affect a person's mental health and overall quality of life.

There are several ways to assess whether someone is overweight or not. One common method is using the BMI, which is calculated based on height and weight. Another method is measuring body fat percentage, which can be done with specialized tools such as skinfold calipers or bioelectrical impedance analysis (BIA).

Losing weight and maintaining a healthy weight can be achieved through a combination of diet, exercise, and lifestyle changes. Some examples of healthy weight loss strategies include:

* Eating a balanced diet that is high in fruits, vegetables, whole grains, and lean protein sources
* Engaging in regular physical activity, such as walking, running, swimming, or weight training
* Avoiding fad diets and quick fixes
* Getting enough sleep and managing stress levels
* Setting realistic weight loss goals and tracking progress over time.

There are several possible causes of hyperglycemia, including:

1. Diabetes: This is a chronic condition where the body either does not produce enough insulin or cannot use insulin effectively.
2. Insulin resistance: This occurs when the body's cells become less responsive to insulin, leading to high blood sugar levels.
3. Pancreatitis: This is inflammation of the pancreas, which can lead to high blood sugar levels.
4. Cushing's syndrome: This is a rare hormonal disorder that can cause high blood sugar levels.
5. Medications: Certain medications, such as steroids and some types of antidepressants, can raise blood sugar levels.
6. Stress: Stress can cause the release of hormones such as cortisol and adrenaline, which can raise blood sugar levels.
7. Infections: Certain infections, such as pneumonia or urinary tract infections, can cause high blood sugar levels.
8. Trauma: Traumatic injuries can cause high blood sugar levels due to the release of stress hormones.
9. Surgery: Some types of surgery, such as heart bypass surgery, can cause high blood sugar levels.
10. Pregnancy: High blood sugar levels can occur during pregnancy, especially in women who have a history of gestational diabetes.

Hyperglycemia can cause a range of symptoms, including:

1. Increased thirst and urination
2. Fatigue
3. Blurred vision
4. Headaches
5. Cuts or bruises that are slow to heal
6. Tingling or numbness in the hands and feet
7. Dry, itchy skin
8. Flu-like symptoms, such as weakness, dizziness, and stomach pain
9. Recurring skin, gum, or bladder infections
10. Sexual dysfunction in men and women

If left untreated, hyperglycemia can lead to serious complications, including:

1. Diabetic ketoacidosis (DKA): A life-threatening condition that occurs when the body produces high levels of ketones, which are acidic substances that can cause confusion, nausea, and vomiting.
2. Hypoglycemia: Low blood sugar levels that can cause dizziness, confusion, and even loss of consciousness.
3. Nerve damage: High blood sugar levels over an extended period can damage the nerves, leading to numbness, tingling, and pain in the hands and feet.
4. Kidney damage: The kidneys may become overworked and damaged if they are unable to filter out the excess glucose in the blood.
5. Eye damage: High blood sugar levels can cause damage to the blood vessels in the eyes, leading to vision loss and blindness.
6. Cardiovascular disease: Hyperglycemia can increase the risk of cardiovascular disease, including heart attacks, strokes, and peripheral artery disease.
7. Cognitive impairment: Hyperglycemia has been linked to cognitive impairment and an increased risk of dementia.

It is essential to manage hyperglycemia by making lifestyle changes, such as following a healthy diet, regular exercise, and taking medication if prescribed by a healthcare professional. Monitoring blood sugar levels regularly can help identify the signs of hyperglycemia and prevent long-term complications.

... or white fat is one of the two types of adipose tissue found in mammals. The other kind is brown adipose ... In humans, white adipose tissue starts to develop during early to mid-gestation period. White adipose tissue consists of white ... White adipose tissue is composed of monolocular adipocytes. In humans, the healthy amount of white adipose tissue varies with ... The visceral adipose tissue is part of the intra-abdominal adipose tissue that surrounds the intestine for the most part. White ...
... (BAT) or brown fat makes up the adipose organ together with white adipose tissue (or white fat). Brown ... These adipocytes are found interspersed in white adipose tissue and are also named 'beige' or 'brite' (for "brown in white"). ... Brown adipose tissue activation may play an important role in bone health and bone density. Brown adipose tissue activation ... in brown adipose tissue disappear, and the tissue becomes similar in function and appearance to white fat. In rare cases, brown ...
The two types of adipose tissue are white adipose tissue (WAT), which stores energy, and brown adipose tissue (BAT), which ... The layer of brown adipose tissue in this depot is often covered by a "frosting" of white adipose tissue; sometimes these two ... The formation of adipose tissue appears to be controlled in part by the adipose gene. Adipose tissue - more specifically brown ... "Adipose Tissue / Structure and Function of White Adipose Tissue". Encyclopedia of Food Sciences and Nutrition. pp. 23-29. doi: ...
Wronska A, Kmiec Z (June 2012). "Structural and biochemical characteristics of various white adipose tissue depots". Acta ... Bone marrow adipose tissue (BMAT), sometimes referred to as marrow adipose tissue (MAT), is a type of fat deposit in bone ... June 2020). "Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis". Nature ... approximates that of white adipose tissue (WAT). The first study to demonstrate exercise regulation of BMAT in rodents was ...
... is produced primarily in the adipocytes of white adipose tissue. It also is produced by brown adipose tissue, placenta ( ... biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity". BioFactors. 37 (6): 413-420 ... both of adipose tissues, as well as of the cartilage and other joint tissues. Alterations in these factors can be the ... "Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix ...
BioFactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity". BioFactors. 37 (6): 413-420 ... Adipose tissue Hepatokines Myokines Mancuso P (May 2016). "The role of adipokines in chronic inflammation". ImmunoTargets and ... secreted by adipose tissue. Some contribute to an obesity-related low-grade state of inflammation or to the development of ...
Bambace, Clara; Dahlman, Ingrid; Arner, Peter; Kulyté, Agné (2013-01-30). "NPC1 in human white adipose tissue and obesity". BMC ... specifically a large excess of white adipose tissue - responsible for dramatically increasing the risks of developing other ...
Lipids are stored in white adipose tissue as triglycerides. In a lean young adult human, the mass of triglycerides stored ... ISBN 978-0-470-04073-7. Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB (2016-04-13). "Adipose Tissue Remodeling: Its Role in Energy ... Chylomicrons will travel through the bloodstream to enter adipose and other tissues in the body. Due to the hydrophobic nature ... storage lipids stored in the adipose tissues are one of the main sources of energy for living organisms. Triacylglycerols, ...
... inflammation and the pleiotropic role of white adipose tissue". Br. J. Nutr. 92 (3): 347-55. doi:10.1079/BJN20041213. PMID ... the haptoglobin gene is expressed in murine and human adipose tissue. Haptoglobin had been shown to be expressed in adipose ... Haptoglobin is produced mostly by hepatic cells but also by other tissues such as skin, lung and kidney. In addition, ... The free heme can then accelerate tissue damage by promoting peroxidative reactions and activation of inflammatory cascades. ...
The white round structures are fat cells. Adipose tissue comprises 25-40% of normal parathyroid gland tissue. High ... Occasionally, an individual's tissues are resistant to the effects of parathyroid hormone. This is known as ... If this situation exists for a prolonged period of time of secondary hyperparathyroidism, the parathyroid tissue may become ... Gross pathology of a parathyroid gland (white arrow), next to the thyroid gland Scheme showing development of branchial ...
It consists of loose connective tissue, adipose tissue and elastin. The main cell types are fibroblasts, macrophages and ... The skin colour of people with light skin is determined mainly by the bluish-white connective tissue under the dermis and by ... The subcutaneous tissue (also hypodermis and subcutis) is not part of the skin, but lies below the dermis of the cutis. Its ... The dermis is the layer of skin beneath the epidermis that consists of connective tissue and cushions the body from stress and ...
"Leptin-specific patterns of gene expression in white adipose tissue". Genes & Development. 14 (8): 963-980. ISSN 0890-9369. PMC ... Both processes take place mainly in liver and adipose tissue. Nevertheless, it also occurs to some extent in other tissues such ... Both the adipose tissue and the liver can synthesize triglycerides. Those produced by the liver are secreted from it in the ... The major sites of fatty acid synthesis are adipose tissue and the liver. Triglycerides are synthesized by esterification of ...
Loss of white adipose tissue reduces levels of inflammation markers. As of 2017 the association of systemic inflammation with ... December 2001). "beta-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies". The Journal of ... Kershaw EE, Flier JS (June 2004). "Adipose tissue as an endocrine organ". The Journal of Clinical Endocrinology and Metabolism ... September 2000). "Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after ...
Crucially, Tbx15 is selectively expressed in brown and "brite" adipose tissue. Knockdown organisms show no change in white ... but not white adipocytes". American Journal of Physiology. Endocrinology and Metabolism. 303 (8): E1053-E1060. doi:10.1152/ ...
"Predominant expression of the mitochondrial dicarboxylate carrier in white adipose tissue". The Biochemical Journal. 344 (2): ... Dicarboxylate carriers are highly abundant in the adipose tissue and play a central role in supplying cytosolic malate for the ...
It functions in the differentiation between white and brown adipose tissue. It can also be a repressor of transforming growth ...
"Fetal development of subcutaneous white adipose tissue is dependent on Zfp423". Molecular Metabolism. 6 (1): 111-124. doi: ...
BMPs are also involved in adipogenesis and functional regulation of adipose tissue. BMP4 favors white adipogenesis, whereas ... Bone morphogenetic protein signaling in adipose tissue". Obesity Reviews. 20 (5): 648-658. doi:10.1111/obr.12822. ISSN 1467- ... There are reports of this therapy causing swelling of soft tissue which in turn can cause life-threatening complications due to ... Bessa PC, Casal M, Reis RL (Jan 2008). "Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the ...
The activity of PRDM16 in white adipose tissue leads to the production of brown fat-like adipocytes within white adipose tissue ... White adipose tissue (WAT) primarily stores excess energy in the form of triglycerides. Recent research has shown that PRDM16 ... This up-regulation lead to the development of a BAT-like phenotype within the white adipose tissue. Expression of PRDM16 has ... PRDM16 is highly enriched in brown adipose cells as compared to white adipose cells, and plays a role in these thermogenic ...
The increase in fatty tissue infiltration occurred regardless of changes in weight or subcutaneous thigh adipose tissue. The ... Rantanen T, Guralnik JM, Foley D, Masaki K, Leveille S, Curb JD, White L (February 1999). "Midlife hand grip strength as a ... December 2009). "Longitudinal study of muscle strength, quality, and adipose tissue infiltration". The American Journal of ... and inter muscular fat showed an increase in adipose tissue infiltration of mid thigh skeletal muscle in both men and women ...
... lacking ANGPTL8 exhibit markedly decreased uptake of Very low-density lipoprotein-derived fatty acids into white adipose tissue ... In mice ANGPTL8 is secreted by the liver and by adipose tissue. Despite having elevated post-heparin plasma LPL activity, mice ... because of the elevated LPL activity in these two tissues, as suggested by the ANGPTL3-4-8 model. ANGPTL8 was proposed to ...
Hutchinson defended adipose tissue against the viewpoint that it was a health risk. He commented that adipose "is really a most ... 2008). White bread bio-politics: Purity, health, and the triumph of industrial baking. Cultural Geographies 15 (1): 19-40. ... New York: James T. White Company. pp. 376-377. Warren, Wilson J. (2018). Meat Makes People Powerful: A Global History of the ... Hutchinson promoted the consumption of red meat and white bread and was strongly opposed to the ideas of vegetarianism. ...
"C/EBPalpha is required for differentiation of white, but not brown, adipose tissue". Proceedings of the National Academy of ... show abnormal adipose tissue formation. Moreover, ectopic expression of C/EBPα in various fibroblast cell lines promotes ... Cao Z, Umek RM, McKnight SL (Sep 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells ... For example, mice lacking C/EBPα in all tissues except the liver (where it is needed to avoid postnatal lethality) ...
... is also expressed by macrophages of adipose tissue, adrenal gland, and placenta. Immunosuppressive tumor-associated ... Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, et al. (November 2015). "CD33 modulates TREM2: convergence of ... Expression was also increased in liver tissues from patients with cirrhosis. Compared with non-tumor liver tissue, TREM2 ... In brain, the highest levels of TREM2 are found in hippocampus, white matter, and the spinal cord, and levels of TREM2 increase ...
Irisin promotes conversion of white adipose tissue (WAT) to brown adipose tissue (BAT) by increasing UCP1 expression. A 2016 in ... May 2019). "Fndc5 loss-of-function attenuates exercise-induced browning of white adipose tissue in mice". The FASEB Journal. 33 ... June 2020). "Impacts of rat hindlimb Fndc5/irisin overexpression on muscle and adipose tissue metabolism". American Journal of ... vitro study of white and brown fat cell tissue found dose-related upregulation of a protein called UCP1 that contributes to the ...
"FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis". Genes & Development. 26 (3): 271-281. ... "FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis". Genes & Development. 26 (3): 271-281. ...
Fietz, J.; Tataruch, F.; Dausmann, K.; Ganzhorn, J. (February 2003). "White adipose tissue composition in the free-ranging fat- ... a relatively short white median facial stripe, and black eye-rings. However, in 2009, Groeneveld et al. demonstrated ...
"The thermogenic activity of rat brown adipose tissue and rabbit white muscle Ca2+-ATPase". IUBMB Life. 57 (4-5): 337-45. doi: ... In addition to its calcium-transporting functions, SERCA1 generates heat in brown adipose tissue and in skeletal muscles. Along ...
March 2015). "Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity". Nature. 519 (7542): 242 ... "Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues ... November 2010). "IL-33 mediates inflammatory responses in human lung tissue cells". Journal of Immunology. 185 (10): 5743-50. ... January 2017). "Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye". The Journal of Pathology. ...
March 2015). "Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity". Nature. 519 (7542): 242 ... ILC2s are essential in the maintenance of homeostasis in lean and healthy adipose tissue. ILC2s resident in visceral adipose ... Beige and brown adipose tissue are specialized in thermogenesis. The process of beiging leads to increased energy expenditure ... by ILC2s act directly on adipocytes to upregulate UCP1 and promote emergence of beige adipocytes in white adipose tissue. ...
... proton gradient generated by electron transport in mitochondria is used to produce heat instead of ATP in brown adipose tissue ... Dormancy of various kinds is expressed in white spruce (Romberger 1963). White spruce, like many woody plants in temperate and ... Dormancy is a general term applicable to any instance in which a tissue predisposed to elongate or grow in some other manner ... Barrero, José M.; Jacobsen, John V.; Talbot, Mark J.; White, Rosemary G.; Swain, Stephen M.; Garvin, David F.; Gubler, Frank ( ...
The epidural space is filled with adipose tissue, and it contains a network of blood vessels. The arachnoid mater, the middle ... "Columns" of white matter carry information either up or down the spinal cord. The spinal cord proper terminates in a region ... "An investigation and validation of CT scan in detection of spinal epidural adipose tissue". Medicine. Wolters Kluwer. 99 (10): ... The spinal cord is a long, thin, tubular structure made up of nervous tissue, which extends from the medulla oblongata in the ...
Since adipose tissue is a potential site of toxin accumulation, it is important to view the impacts that environmental toxins ... Tang T, Glanville J, Hayden CJ, White D, Barth JH, Balen AH (January 2006). "Combined lifestyle modification and metformin in ... Gonadal heat can rise with an increase in fat or adipose tissue in the scrotum. Spermatogenesis is a temperature-sensitive ... Jackson E, Shoemaker R, Larian N, Cassis L (September 2017). "Adipose Tissue as a Site of Toxin Accumulation". Comprehensive ...
... and adipose tissues. There is moderate expression in the brain, pancreas, mammary glands, and ovaries. Finally, there is little ... ". "Genecards: DHRS7B Gene protein-coding GIFtS 47". Tannin GM, Agarwal AK, Monder C, New MI, White PC (September 1991). "The ... CD44 is an antigen found on the surface of most cell types and functions as a receptor that binds tissue macromolecules. ... Structure, tissue distribution, and chromosomal localization". J. Biol. Chem. 266 (25): 16653-8. doi:10.1016/S0021-9258(18) ...
The ACTH receptor plays a role in glucose metabolism when expressed in white adipose cells. When bound to ACTH, a short-term ... In humans, ACTH has little lipolytic effect on adipose tissue. ACTH receptor activation also influences immune function. ... ACTH receptors are also expressed in the skin, and in both white and brown adipocytes, and is expressed in greater ... "Melanocortin crosstalk with adipose functions: ACTH directly induces insulin resistance, promotes a pro-inflammatory adipokine ...
... the small intestine and adipose tissue. Factors that act upon the ABCA1 transporter's expression or its posttranslational ... ABC genes are divided into seven distinct subfamilies (ABCA, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member ... It is present in higher quantities in tissues that shuttle or are involved in the turnover of lipids such as the liver, ...
... are formed in adipose tissue, improve glucose tolerance and also reduce adipose tissue inflammation. Palmitic acid esters of ... block apoptosis by inhibiting acid SMase in white blood cells within tissues (macrophages) and increase intracellular free ... It is found at very low levels (nM) in most tissues and is inactivated by the fatty acid amide hydrolase. Subsequently, another ... It is present at approximately 100-times the concentration of anandamide in most tissues. Elevations in either of these lipids ...
There are many ways in which obesogenic drugs and chemicals can disrupt the body's adipose tissue biology. The three main ... Hines EP, White SS, Stanko JP, Gibbs-Flournoy EA, Lau C, Fenton SE (May 2009). "Phenotypic dichotomy following developmental ... There are many different proposed mechanisms through which obesogens can interfere with the body's adipose tissue biology. ... adipose tissues, and from within the brain. It is these types of signals that provide a likely target for obesogens that have ...
In obesity, the excess of adipose tissue increases conversion of androstenedione into estrone, an estrogen. Higher levels of ... In the United States, white women have a higher survival rate than black women, who tend to develop more aggressive forms of ... removal of endometrial tissue; D&C). This tissue is then examined histologically for characteristics of cancer. If cancer is ... The buildup of extra cells often forms a mass of tissue called a growth or tumor. These abnormal cancer cells have many genetic ...
This reaction occurs in both the gonads and in certain other tissues, particularly adipose tissue, and estrone is subsequently ... It is a white, odorless, solid crystalline powder, with a melting point of 254.5 °C (490 °F) and a specific gravity of 1.23. ... though they can also be formed from adrenal androgens in adipose tissue. Relative to estradiol, both estrone and estriol have ... in various tissues, including the liver, uterus, and mammary gland. Estrone is bound approximately 16% to sex hormone-binding ...
On the other hand, adipose tissue is known to secrete various metabolites, hormones and cytokines that may play a role in ... This includes replacing white bread with whole-grain bread, reducing intake of foods composed primarily of starch such as ... Specifically cytokines secreted by adipose tissue directly affect the insulin signalling cascade, and thus insulin secretion. ... Obesity is characterized by an excess of adipose tissue - insulin increases the synthesis of fatty acids from glucose, ...
Other examples include micrograft surgery, which involves the deposition of adipose tissue, previously taken from the waist, ... White and African-American young men and women. Psychologists have argued that evolutionary selection processes have ... Both android and gynoid fat are found in female breast tissue. Females develop breasts around puberty and breasts with less ...
Several species also possess either a ventral or dorsal adipose fin, and the caudal fin is forked to emarginated. The anal fin ... but are enclosed within a large transparent dome of soft tissue. These eyes generally gaze upwards, but can also be directed ... leaving the body itself a transparent white. In all species, a variable number of dark melanophores colour the muzzle, ventral ...
X-linked hypertrichosis Conditions of the subcutaneous fat are those affecting the layer of adipose tissue that lies between ... White piedra White superficial onychomycosis Zygomycosis (phycomycosis) Parasitic infestations, stings, and bites in humans are ... The subcutaneous tissue is a layer of fat between the dermis and underlying fascia. This tissue may be further divided into two ... The main cellular component of this tissue is the adipocyte, or fat cell. The structure of this tissue is composed of septal (i ...
Before dry season, they will accumulate fat in white adipose tissue located at the base of the tail and hind legs, doubling ... Most lemurs have retained the tapetum lucidum, a reflective layer of tissue in the eye, which is found in many vertebrates. ... Only the ring-tailed lemur, the bamboo lemurs (genus Hapalemur), and the black-and-white ruffed lemur (Varecia variegata) are ... One of their major projects involved the release of captive black-and-white ruffed lemurs, designed to help restock the ...
Continual daily doses of diazepam quickly build to a high concentration in the body (mainly in adipose tissue), far in excess ... Diazepam occurs as solid white or yellow crystals with a melting point of 131.5 to 134.5 °C. It is odorless, and has a slightly ... After absorption, diazepam is redistributed into muscle and adipose tissue. ...
The epidural space is filled with adipose tissue, and it contains a network of blood vessels. The arachnoid mater is the middle ... "Columns" of white matter carry information either up or down the spinal cord. Within the CNS, nerve cell bodies are generally ... Together, the gray horns and the gray commissure form the "gray H." The white matter is located outside of the gray matter and ... The spinal cord is protected by three layers of tissue, called spinal meninges, that surround the canal. The dura mater is the ...
In the absence of inflammation 10-35% of circulating IL-6 may come from adipose tissue. IL-6 is produced by adipocytes and is ... Sadagurski M, Norquay L, Farhang J, D'Aquino K, Copps K, White MF (March 2010). "Human IL6 enhances leptin action in mice". ... Bastard JP, Jardel C, Delattre J, Hainque B, Bruckert E, Oberlin F (April 1999). "Evidence for a link between adipose tissue ... April 2019). "Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled ...
... adipose) tissue of CCR2 deficient mice, there is an increased number of eosinophils, greater alternative macrophage activation ... Berkhout TA, Sarau HM, Moores K, White JR, Elshourbagy N, Appelbaum E, Reape RJ, Brawner M, Makwana J, Foley JJ, Schmidt DB, ... and type 2 cytokine expression in adipose tissue". Journal of Leukocyte Biology. 98 (4): 467-77. doi:10.1189/jlb.3HI0115-018R. ... and affects monocytes recruitment in tissues including the heart. As a consequence when an acute ischemic event happens during ...
It is highly expressed in white adipose tissue, with lower expression in heart, skeletal muscle, and brown adipose tissue. ... PLIN4 is a member of the perilipin family, a group of proteins that coat lipid droplets in adipocytes, the adipose tissue cells ... Calcified Tissue International. 90 (2): 96-107. doi:10.1007/s00223-011-9552-7. PMC 3628693. PMID 22210160. Peters SJ, Samjoo IA ... Calcified Tissue International. 90 (2): 96-107. doi:10.1007/s00223-011-9552-7. PMC 3628693. PMID 22210160. Brasaemle DL ( ...
Fructose in muscles and adipose tissue is phosphorylated by hexokinase. Although the metabolism of fructose and glucose share ... It is also present in the form of refined sugars including granulated sugars (white crystalline table sugar, brown sugar, ... present on adipose tissue and skeletal muscle. Fructose-1-phosphate then undergoes hydrolysis by fructose-1-phosphate aldolase ... In addition to the liver, fructose is metabolized in the intestines, testis, kidney, skeletal muscle, fat tissue and brain, but ...
In a 2005 study, the mean volume of adipose tissues (in the external part of the hump that have cells to store lipids) is ... The semen of a Bikaneri dromedary is white and viscous, with a pH of around 7.8. A single calf is born after a gestation period ... The hump is composed of fat bound together by fibrous tissue. There are no glands on the face; males have glands that appear to ... When this tissue is metabolized, through fat metabolization, it releases energy while causing water to evaporate from the lungs ...
When they build up in adipose tissue, they can be transferred across the placenta. In addition to all, air pollution has been ... Lead researcher Deborah Cory-Slechta said that: "When we looked closely at the ventricles, we could see that the white matter ... Blacks and Latinos generally face more pollution than whites and Asians, and low-income communities bear a higher burden of ... Asbestosis is a chronic inflammatory medical condition affecting the tissue of the lungs. It occurs after long-term, heavy ...
... of mandible condyle cone cell confluence of the sinuses conjoint tendon conjugate eye movement conjunctiva connective tissue ... vomer vomeronasal organ vomiting center vorticosae vulva Waldeyer's ring Wernicke's area Wharton's duct Wharton's jelly white ... olivary nucleus accommodation reflex acetabulum Achilles tendon acoustic nerve acromion adenohypophysis adenoids adipose aditus ... neuron motor unit mouth mucoperiosteum mucosa mucous membranes multifidus muscle muscle fascicle muscle spindle muscle tissue ...
... its depletion in adipocytes causes alterations in the structure of both brown and white adipose tissue, along with brown fat ... A model knocking out Noggin specifically in adipocytes has allowed to elucidate that Noggin also plays a role in adipose tissue ... Additionally, it has been shown that Noggin depletion in adipose tissue leads to obesity. The secreted polypeptide noggin, ... Noggin, also known as NOG, is a protein that is involved in the development of many body tissues, including nerve tissue, ...
... storage and metabolism of adipose tissue, and perceiving temperature. Genes related to both sensing temperature and ... "white gold". Local dealers estimate that 10 million mammoths are still frozen in Siberia, and conservationists have suggested ... Soft tissue apparently was less likely to be preserved between 30,000 and 15,000 years ago, perhaps because the climate was ... Apart from frozen remains, the only soft tissue known is from a specimen that was preserved in a petroleum seep in Starunia, ...
"Effects of rapid glucose infusion on in vivo and in vitro free fatty acid re-esterification by adipose tissue of fasted obese ... Chua, SC Jr; White, DW; Wu-Peng, XS; Liu, SM; Okada, N; Kershaw, EE; Chung, WK; Power-Kehoe, L; Chua, M; Tartaglia, LA; Leibel ... and on the control of fatty acid re-esterification in human adipose tissue. Being among the first investigators to describe ... "A radioisotopic technique for analysis of free fatty acid reesterification in human adipose tissue". Am J Physiol. 248 (1 Pt 1 ...
... or preadipocytes isolated from the stromal-vascular fraction of white adipose tissue. In vitro differentiation is a highly ... Senescent adipose progenitor cells in subcutaneous adipose tissue has been shown to suppress adipogenic differentiation. ... Reduced adipogenesis in obese persons is due to increased senescent cells in adipose tissue rather than reduced numbers of stem ... October 1999). "PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro". Molecular Cell. 4 (4): ...
... and microRNAs that affect the function of cells and tissues throughout the body. Accumulation of visceral white adipose tissue ... Adipose tissue not only stores energy, but also controls metabolism through secretion of hormones, cytokines, proteins, ... While much attention has been paid to identifying differences between white, brown and brite/beige adipocytes, there is growing ... The following chapter will introduce this concept of white adipocyte heterogeneity. ...
Glucose and lipid metabolism are closely linked in white adipose tissue (WAT), yet the underlying mechanisms of the effect of ... Endoplasmic reticulum stress may be involved in insulin resistance and lipid metabolism disorders of the white adipose tissues ... Endoplasmic reticulum stress may be involved in insulin resistance and lipid metabolism disorders of the white adipose tissues ... White Rose Research Online is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the ...
Impaired white adipose tissue fatty acid metabolism in mice fed a high-fat diet worsened by arsenic exposure, primarily ... Fatty acid (FA) metabolism dysfunction of white adipose tissue (WAT) underlies obesity and insulin resistance in response to ... Impaired white adipose tissue fatty acid metabolism in mice fed a high-fat diet worsened b ... Arsenic; Fatty acid metabolism; High-fat diet; Insulin resistance; Lipolysis; White adipose tissue ...
However, the impact of influenza infection on white adipose tissue (WAT), a key tissue in the control of systemic energy ... Overall, our findings shed light on the role that the white adipose tissue, which lies at the crossroads of nutrition, ... They find that infection is associated with the browning of the subcutaneous white adipose tissue (WAT), and this change is ... linked to viral infection in the fat tissues. ... White adipose tissue (WAT) is a key metabolic organ. It has a ...
Adipose tissue (AT) metabolism is dysregulated in obesity. Reduced brown adipose tissue (BAT) glucose uptake during cold ... Brown and white adipose tissue metabolism in obesity: stimulation by cold and meal ingestion. Saari, Teemu (2022-05-21). Brown ... Increased subcutaneous adipose tissue (SAT) perfusion after a meal is reduced in obesity, leading to the accumulation of ... and white adipose tissue metabolism in obesity: stimulation by cold and meal ingestion ...
The group conducts research on genetics and studies how human abdominal adipose tissue contributes to obesity-related ... adipose ... tissue ... white ...
These findings showed that mouse adipose tissue contains a population of cells with molecular resemblance to embryonic stem ... The expression pattern of pluripotency markers in adipose tissue-derived stem cells (ADSCs) is a subject of controversy. ... White adipose tissue represents a rich source of stem cells with potential applications in basic and clinical research. Adipose ... These findings show that white adipose tissue is containing a population of pluripotent stem cells with molecular resemblance ...
TGF-β/Smad3 Signaling Regulates Brown Adipocyte Induction in White Adipose Tissue.. Yadav H, Rane SG.. Front Endocrinol ( ... Flow Cytometry Assisted Isolation of Adipose Tissue Derived Stem Cells.. Wankhade UD, Rane SG.. Methods Mol Biol (2017) 1566:17 ... TGF-β receptor 1 regulates progenitors that promote browning of white fat.. Wankhade UD, Lee JH, Dagur PK, Yadav H, Shen M, ...
Ethnic differences in visceral adipose tissue and type 2 diabetes: Filipino, African-American, and white women. Obes Res 2005; ... FA engagement in health promotion is critical because FAs continue to have a higher prevalence of chronic diseases than whites ... more likely to have hypertension than other Asians or whites (4). An estimated 28% of FAs have CVD (6), and FAs are diagnosed ... with diabetes 8.4 years earlier than whites (11).. FAs also report a high prevalence of behavioral risk factors such as obesity ...
Prescription DHEA is available to treat thin vaginal tissue. ... up-regulates resistin gene expression in white adipose tissue. ... treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue. Mol.Cell Endocrinol. 5-14-2010; ... Quantitative determination of dehydroepiandrosterone fatty acyl esters in human female adipose tissue and serum using mass ... Thinning of vaginal tissue (vaginal atrophy). Using vaginal inserts containing DHEA can reduce pain during sex by up to 15% ...
However, the role of Sal B in white adipose tissue (WAT) is not yet clear. ... in epididymal white adipose tissue induced by a high fat diet in obese mice. ... Background: Adipose tissue plays a central role in obesity-related metabolic diseases such as type 2 diabetes. Salvianolic acid ... Other pathways may play an important role in the formation and differentiation of adipose tissue, such as B cell receptor ...
... pericardial white adipose tissue. ... Adipose tissue - White. Female. observed. 259 days. * Notes. ...
Activation of METTL3 promotes white adipose tissue beiging and combats obesity Renxiang Xie, Sujun Yan, Xiaoling Zhou, Yunyi ... Click here to open pdf in another window PDF for Activation of METTL3 promotes white adipose tissue beiging and combats obesity ... View article titled, Activation of METTL3 promotes white adipose tissue beiging and combats obesity ...
Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets. J Vis Exp. 2020 02 16; (156). ... Diverse Approaches to Ovarian Tissue Cryopreservation Have Equivalent Outcomes in Markers of Tissue Viability. Reprod Sci. 2021 ... "Tissue Survival" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Tissue-based markers of right ventricular dysfunction in ischemic mitral regurgitation assessed via stress cardiac magnetic ...
Liver kinase b1 is required for white adipose tissue growth and differentiation. Diabetes 2013-01-01 [PMID: 23396401] (WB, ... May see 1 or 2 minor cross-reacting lower MW bands in liver tissue. In ICC/IF cytoplasmic staining can be seen in MCF7 cells. ... A: total RNA (1 ug) isolated from different tissues (brain, hypothalamus, liver and muscle) was ...read more ... For this, both human and mouse tissues are applicable to HIER pH 6. ...
White adipose tissue (WAT) is a major endocrine and secretory organ, which releases a wide range of protein signals and factors ... Signalling role of adipose tissue: adipokines and inflammation in obesity P. Trayhurn; P. Trayhurn 1 ... P. Trayhurn, I.S. Wood; Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 26 October ... of inflammatory markers and the expression and release of inflammation-related adipokines generally rises as adipose tissue ...
There are two types of body fat: white adipose tissue (WAT) and brown adipose tissue (BAT). WAT stores calories while BAT burns ...
Brown fat is a lesser-known cousin of white fat. You may be aware of the functioning of white fat tissues - it stores calories ... In contrast, brown adipose tissues burn fat to release heat. Their function is to provide heat to the body, and thats why ... Due to the fat-burning capabilities of brown adipose tissues, they are being touted as the secret weapon against extra fat. You ... And, we have learned that a higher proportion of brown adipose tissues means extra fat burning, more heat, and less weight. ...
... low brown adipose tissue levels. This formula helps your body create more brown adipose tissue so your body can naturally burn ... White Korean Ginseng: Ginseng is known to energize cells and activate a healthy inflammatory response that allows your body to ... This is done by the brown tissues. The brown adipose tissues get their brown color from dense mitochondria that mainly work to ... Exipure DR Lam is designed in such a way that it targets the root cause (lack of BAT- brown adipose tissues) and ensures your ...
Nanoparticles show promise delivering antiobesity drugs directly into fat tissue. ... These drugs turn white adipose tissue into brown adipose tissue that burns fat and also stimulates the growth of new blood ... This is a proof-of-concept approach for selectively targeting the white adipose tissue and browning it to allow the body to ... Researchers hope to find more specific adipose tissue targets that could lessen the possibility of side effects. ...
White adipose tissue (WAT) remodeling is dictated by coordinated interactions between adipocytes and resident stromal-vascular ... Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of ... cells; however, the functional heterogeneity of adipose stromal cells has remained unresolved. We combined single-cell RNA- ...
Leptin is produced by white adipose tissue and has a prominent role in regulating appetite and energy expenditure via its ...
THs exert effects in several other tissues, including the brain, liver, and gut (3). Within the circulation, THs are mainly ... role in the human organism owing to the substantial expression of their corresponding nuclear receptors in almost all tissues ( ... In particular, positive associations with NEFAs were observed, suggesting increased lipolysis from white adipose tissue with ... In particular, positive associations with NEFAs were observed, suggesting increased lipolysis from white adipose tissue with ...
... hour fasting experiment and then focused on the global gene expression changes in epididymal white adipose tissue (WAT) as well ... our bioinformatic analyses indicate p53 as central node in the regulation of fasting in major metabolic tissues; and (iv) ... Frozen samples of white adipose tissue, liver, and skeletal muscle collected at the 24 hour time point were used for microarray ... ii) To our knowledge this is the first study focusing on the transcriptome response of white adipose tissue in fasted mice. ...
Resistin is an adipose-tissue-derived peptide hormone discovered in 2001 and shown to be involved in the link between insulin ... Interestingly, the leptin-to-adiponectin ratio negatively correlates with insulin sensitivity in non-diabetic White individuals ... Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J. 2008 Dec;29(24):2959-71. PMID:18775919 ... Adipose tissue releases several protein hormones that regulate energy homeostasis and lipid and carbohydrates metabolism (17). ...
... and Lipid Metabolism Disorders in Obese Mice Activating Brown Adipose Tissue and Inducing Browning of White Adipose Tissue. ... and tissue development, involve receptors that mediate membrane contact and initiate fusion and effectors that execute membrane ...
Caffeine can promote brown adipose tissue function and improve thermogenesis, helping to burn fat more efficiently. ... Brown adipose tissue (BAT), also known as brown fat, is one of two types of fat found in humans and other mammals. Initially ... Its main function is to generate body heat by burning calories (as opposed to white fat, which is a result of storing excess ... BATbody mass indexbrain researchBrown Adipose Tissuebrown fatCaffeineCoffeeneurobiologyNeuroscienceobesityOpen Accessopen ...
  • Illumina Hiseq 4000 was used to study the effects of Sal B on the expression of long non-coding RNA (lncRNA) and circular RNA (circRNA) in epididymal white adipose tissue induced by a high fat diet in obese mice. (nih.gov)
  • We investigated the dynamic changes of liver gene expression and serum parameters of mice at several time points during a 48 hour fasting experiment and then focused on the global gene expression changes in epididymal white adipose tissue (WAT) as well as on pathways common to WAT, liver, and skeletal muscle. (biomedcentral.com)
  • Accumulation of visceral white adipose tissue (WAT) leads to central obesity and is associated with insulin resistance and increased risk of metabolic disease, whereas accumulation of subcutaneous WAT leads to peripheral obesity and may be protective of metabolic syndrome. (intechopen.com)
  • Visceral adipose tissue (VAT) accumulation is considered more detrimental to metabolic health compared to SAT. Discovering what changes occur in VAT metabolism in obesity, and after weight loss, could help elucidate the role of VAT in metabolic disease. (utupub.fi)
  • PCOS and COVID-19 relationship", publicado na Rev Endocr Metab aumento do tecido adiposo visceral. (bvsalud.org)
  • The group conducts research on genetics and studies how human abdominal adipose tissue contributes to obesity-related complications and insulin resistance. (ki.se)
  • Besides genetics, the focus of Ingrid´s research is how human abdominal adipose tissue contributes to obesity-related complications and insulin resistance. (ki.se)
  • In the single dose experiments, selected hens were killed at various times ranging from 1 hour up to 28 days after dosing and abdominal adipose tissue was removed and assayed for leptophos. (cdc.gov)
  • The necrosis extended into all the abdominal adipose tissue at the rectus abdominis muscle and linea alba. (cdc.gov)
  • Increased subcutaneous adipose tissue (SAT) perfusion after a meal is reduced in obesity, leading to the accumulation of ectopic fat, increasing the risk of type 2 diabetes (T2D). (utupub.fi)
  • Measures of subcutaneous adipose tissue are important because individuals with large values are reported to be at increased risks for hypertension, adult-onset diabetes mellitus, cardiovascular disease, gallstones, arthritis, and other disease, and forms of cancer. (cdc.gov)
  • Adipose tissue not only stores energy, but also controls metabolism through secretion of hormones, cytokines, proteins, and microRNAs that affect the function of cells and tissues throughout the body. (intechopen.com)
  • Glucose and lipid metabolism are closely linked in white adipose tissue (WAT), yet the underlying mechanisms of the effect of iTFAs in WAT are poorly understood. (whiterose.ac.uk)
  • Impaired white adipose tissue fatty acid metabolism in mice fed a high-fat diet worsened by arsenic exposure, primarily affecting retroperitoneal adipose tissue. (bvsalud.org)
  • Fatty acid (FA) metabolism dysfunction of white adipose tissue (WAT) underlies obesity and insulin resistance in response to high calorie intake and/or endocrine-disrupting chemicals (EDCs), among other factors. (bvsalud.org)
  • Overall, our findings shed light on the role that the white adipose tissue, which lies at the crossroads of nutrition, metabolism and immunity, may play in influenza infection. (nature.com)
  • Adipose tissue (AT) metabolism is dysregulated in obesity. (utupub.fi)
  • Reduced brown adipose tissue (BAT) glucose uptake during cold exposure is associated with obesity and insulin resistance, but the role of fatty acids in human BAT metabolism is unclear. (utupub.fi)
  • For this purpose we have access to a unique cohort with details of abdominal adipose morphology and metabolism determined in 950 adults. (ki.se)
  • If you often suffer from bloating, slowed down energy and pace, poor mood, increased appetite, and cravings, you should know that your body has a poor metabolism due to the lack of brown adipose tissues. (ipsnews.net)
  • Exipure DR Lam is designed in such a way that it targets the root cause (lack of BAT- brown adipose tissues) and ensures your metabolism works faster than ever before. (ipsnews.net)
  • 2021). Emodin Improves Glucose and Lipid Metabolism Disorders in Obese Mice Activating Brown Adipose Tissue and Inducing Browning of White Adipose Tissue. (tcdb.org)
  • The expression of glucose-regulated protein 78 (GRP78) and the phosphorylation of inositol-requiring enzyme 1-alpha and c-Jun N-terminal kinase (JNK) were significantly increased in subcutaneous and retroperitoneal adipose depots of HFD-M-fed rats. (whiterose.ac.uk)
  • The authors conclude that leptophos is readily absorbed by the adipose tissue of hens and induces delayed neurotoxicity. (cdc.gov)
  • Adipose tissue plays a central role in obesity-related metabolic diseases such as type 2 diabetes. (nih.gov)
  • Residue and accumulation of phosvel in adipose tissue of hens. (cdc.gov)
  • The accumulation of phosvel (21609905) (leptophos) in adipose tissue was studied in hens. (cdc.gov)
  • The aim of our research is to define genetic variants acting in adipose tissue to influence risk of abdominal obesity and type 2 diabetes. (ki.se)
  • Fatty tissue composed of WHITE ADIPOCYTES and generally found directly under the skin (SUBCUTANEOUS FAT) and around the internal organs (ABDOMINAL FAT). (bvsalud.org)
  • While much attention has been paid to identifying differences between white, brown and brite/beige adipocytes, there is growing evidence that there is functional heterogeneity among white adipocytes themselves. (intechopen.com)
  • Retroperitoneal was the WAT most affected, where the combination of arsenic and HFD in contrast to HFD, generated higher adipose weight, larger adipocytes , increased triglyceride content, and decreased fasting stimulated lipolysis evidenced by lower phosphorylation of HSL and perilipin . (bvsalud.org)
  • These hyphae extended toward the hypodermic fat tissues and were associated with a break in the cell membrane of adipocytes and with crystals inside the adipocytes. (cdc.gov)
  • Other pathways may play an important role in the formation and differentiation of adipose tissue, such as B cell receptor signaling. (nih.gov)
  • Human adipose tissue expresses interleukin-6, a cytokine that activates the production of C-reactive protein from the liver, potentially inducing low-grade systemic inflammation in persons with excess body fat. (who.int)
  • Obesity is characterized by a state of chronic mild inflammation, with raised circulating levels of inflammatory markers and the expression and release of inflammation-related adipokines generally rises as adipose tissue expands (adiponectin, which has anti-inflammatory action is an exception). (portlandpress.com)
  • Adipose tissue is organized in discrete depots in specific locations throughout the body. (intechopen.com)
  • We will introduce the major different WAT depots and more fully elaborate the physiology of two more recently defined depots: the dermal and bone marrow adipose tissue. (intechopen.com)
  • The prevalence of obesity, characterized by excess of adipose tissue, has been increasing worldwide and represents one of the most significant public health problems of our time. (intechopen.com)
  • Once there's an adequate supply of BAT in the body, it naturally burns the excess deposit of white fat and helps you gain the much adorned leaner shape. (marylandreporter.com)
  • You may be aware of the functioning of white fat tissues - it stores calories in the form of fat which appears around the body as excess flab. (marylandreporter.com)
  • Its main function is to generate body heat by burning calories (as opposed to white fat, which is a result of storing excess calories). (neurosciencenews.com)
  • Exipure tropical loophole targets BAT or Brown Adipose Tissues. (marylandreporter.com)
  • Researchers hope to find more specific adipose tissue targets that could lessen the possibility of side effects. (pharmacytimes.com)
  • Caffeine can promote brown adipose tissue function and improve thermogenesis, helping to burn fat more efficiently. (neurosciencenews.com)
  • The span of viability of a tissue or an organ. (harvard.edu)
  • White adipose tissue (WAT) is a major endocrine and secretory organ, which releases a wide range of protein signals and factors termed adipokines. (portlandpress.com)
  • In contrast, brown adipose tissues burn fat to release heat. (marylandreporter.com)
  • In contrast to white anatomy, the Asian eyelid has more fullness of the upper eyelid, narrower palpebral fissures, medial epicanthal folds, and a lid crease closer to the eyelid margin. (medscape.com)
  • Tissue Survival" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • The goal of surgical treatment of basal cell carcinoma (BCC) is to destroy or remove the tumor so that no malignant tissue is allowed to proliferate further. (medscape.com)
  • Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1). (neurosciencenews.com)
  • In 6 month old hens given 250mg/kg leptophos, peak adipose tissue leptophos concentrations of 25.1 parts per million (ppm) occurred 1 day after dosing. (cdc.gov)
  • In 21 month old hens given 250mg/kg leptophos adipose tissue concentrations averaged 9.52ppm 1 day after dosing, decreasing slowly thereafter. (cdc.gov)
  • Adipose tissue leptophos concentrations in hens given 5 or 10mg/kg increased progressively for 21 days, decreasing slowly thereafter. (cdc.gov)
  • In birds given 20mg/kg daily, adipose tissue leptophos concentrations increased slowly for 14 days, then rose rapidly thereafter. (cdc.gov)
  • However, the impact of influenza infection on white adipose tissue (WAT), a key tissue in the control of systemic energy homeostasis, has not been yet characterized. (nature.com)
  • Persistence of necrotic tissues at the infection site required additional surgical debridement on day 10. (cdc.gov)
  • This chapter will briefly introduce the two major types of fat, brown and white. (intechopen.com)
  • TGF-β/Smad3 Signaling Regulates Brown Adipocyte Induction in White Adipose Tissue. (nih.gov)
  • There are two types of body fat: white adipose tissue (WAT) and brown adipose tissue (BAT). (dane101.com)
  • Brown fat is a lesser-known cousin of white fat. (marylandreporter.com)
  • Their function is to provide heat to the body, and that's why young ones have heaps of brown adipose tissues - they help the babies stay warm. (marylandreporter.com)
  • Due to the fat-burning capabilities of brown adipose tissues, they are being touted as the secret weapon against extra fat. (marylandreporter.com)
  • And, we have learned that a higher proportion of brown adipose tissues means extra fat burning, more heat, and less weight. (marylandreporter.com)
  • Exipure DR Lam is formulated to fight the root cause of obesity in men and women: low brown adipose tissue levels. (ipsnews.net)
  • This formula helps your body create more brown adipose tissue so your body can naturally burn more fats. (ipsnews.net)
  • As per a report and study published in 2021, many scientists have finally agreed to the fact that the root cause of obesity is low brown adipose tissue levels. (ipsnews.net)
  • This is done by the brown tissues. (ipsnews.net)
  • The brown adipose tissues get their brown color from dense mitochondria that mainly work to shrink and burn fat 24 x 7 . (ipsnews.net)
  • It has been proven to boost the brown adipose tissues to help your body shrink more fats. (ipsnews.net)
  • Like other ingredients, holy basil being a herb helps detoxify the cells and improve the brown adipose tissues composition to help you melt more fat. (ipsnews.net)
  • Also known as Olea Europaea, this ingredient helps improve the quantity of BAT (brown adipose tissue) that helps the fat to shrink from fat cells. (ipsnews.net)
  • These drugs turn white adipose tissue into brown adipose tissue that burns fat and also stimulates the growth of new blood vessels (angiogenesis) in fat tissue. (pharmacytimes.com)
  • This helps the nanoparticle target cells and helps in turning white tissue brown. (pharmacytimes.com)
  • Brown adipose tissue (BAT), also known as brown fat, is one of two types of fat found in humans and other mammals. (neurosciencenews.com)
  • Tissue-based markers of right ventricular dysfunction in ischemic mitral regurgitation assessed via stress cardiac magnetic resonance and three-dimensional echocardiography. (harvard.edu)
  • Anthropometry is the study of the measurement of the human body in terms of the dimensions of bone, muscle, and adipose (fat) tissue. (cdc.gov)
  • This can be very dangerous for your overall health as the lack of these tissues can force the body to accumulate more fat. (ipsnews.net)
  • This is a proof-of-concept approach for selectively targeting the white adipose tissue and 'browning it' to allow the body to burn fat. (pharmacytimes.com)
  • White adipose tissue represents a rich source of stem cells with potential applications in basic and clinical research. (hindawi.com)
  • Research shows that FAs are 18% more likely to have hypertension than other Asians or whites (4). (cdc.gov)
  • May see 1 or 2 minor cross-reacting lower MW bands in liver tissue. (novusbio.com)
  • Tumors that are aggressive and those occurring near vital or cosmetically sensitive structures are best treated with methods that allow for an examination of the tissue margins. (medscape.com)
  • A diagnosis of zygomycosis was made after direct examination and histopathologic examination of the tissue samples. (cdc.gov)
  • In the multiple dose experiment the hens were killed after the last dose and the adipose tissue was analyzed for leptophos as before. (cdc.gov)
  • Using target tissue, dose estimates, instead of external or criteria and a thorough and efficient review process can reduce the applied doses, can improve the characterization of dose-response number of review and revision iterations and hence the time needed relationship and subsequent characterization of potential health to prepare a model for application. (cdc.gov)
  • FA engagement in health promotion is critical because FAs continue to have a higher prevalence of chronic diseases than whites, blacks, and other Asian groups (3-6). (cdc.gov)
  • ADSCs were isolated from the inguinal adipose tissue of 10-12-week-old Balb/c mice using 2 mg/mL collagenase A (Roche, Mannheim, Germany) digestion, as previously described [ 9 ]. (hindawi.com)
  • A recent study used nanoparticles to deliver antiobesity drugs directly into the fat tissue in overweight mice models. (pharmacytimes.com)
  • The expression pattern of pluripotency markers in adipose tissue-derived stem cells (ADSCs) is a subject of controversy. (hindawi.com)
  • These findings showed that mouse adipose tissue contains a population of cells with molecular resemblance to embryonic stem cells, and LIF and miR-302 family positively affect the expression of pluripotency markers. (hindawi.com)
  • Diverse Approaches to Ovarian Tissue Cryopreservation Have Equivalent Outcomes in Markers of Tissue Viability. (harvard.edu)
  • However, the role of Sal B in white adipose tissue (WAT) is not yet clear. (nih.gov)
  • Role of 3-Dimensional Architecture of Scar and Surviving Tissue in Ventricular Tachycardia: Insights From High-Resolution Ex Vivo Porcine Models. (harvard.edu)
  • Leptin is produced by white adipose tissue and has a prominent role in regulating appetite and energy expenditure via its actions in the hypothalamus. (umc.edu)
  • Thyroid hormones (THs), with triiodothyronine (T3) and thyroxine (T4) as the major secretion products of the thyroid gland, play a vital role in the human organism owing to the substantial expression of their corresponding nuclear receptors in almost all tissues (1). (deepdyve.com)
  • Preconditioning of surgical pedicle flaps with DNA plasmid expressing hypoxia-inducible factor-1a (HIF-1a) promotes tissue viability. (harvard.edu)
  • These features are all evaluated in the assessment of the upper eyelid and in the planning for surgical procedures to alter the periorbital tissue. (medscape.com)
  • An estimated 28% of FAs have CVD (6), and FAs are diagnosed with diabetes 8.4 years earlier than whites (11). (cdc.gov)
  • Die verskynsel kan moontlik die verhoogde risiko vir diabetes mellitus, koronêre hartsiektes en al die ander kroniese toestande wat voorkom by obesiteit verduidelik. (who.int)
  • White fat provides heat insulation, mechanical cushion, and source of energy. (bvsalud.org)
  • Adipose tissue-derived stem cells (ADSCs) can be harvested from patients by a simple and minimally invasive method. (hindawi.com)
  • Isolated cells were counted and plated at 5 × 10 4 cells/mL seeding density in 6 cm tissue culture plates and cultured in Dulbecco's modified eagle's medium (DMEM, Gibco, Life Technologies, USA) with 20% fetal bovine serum (FBS, Gibco). (hindawi.com)
  • Flow Cytometry Assisted Isolation of Adipose Tissue Derived Stem Cells. (nih.gov)
  • It rejuvenates and repairs aging cells so your skin, cells, tissues, and muscles remain fresh and active. (ipsnews.net)
  • Plasma, muscle, and adipose samples will be subjected to global transcriptome and metabolomic analyses. (ki.se)
  • Culture of tissues samples on Sabouraud-chloramphenicol-gentamicin agar after 4 days at 30°C and 37°C grew a white aerial mold, which covered the entire surface of the agar. (cdc.gov)
  • This graph shows the total number of publications written about "Tissue Survival" by people in Harvard Catalyst Profiles by year, and whether "Tissue Survival" was a major or minor topic of these publication. (harvard.edu)
  • [ 2 ] In addition to standard suture techniques, tissue adhesives have also been used for skin closure. (medscape.com)
  • Finally, healing by secondary intention (granulation) often leads to atrophic white scars that may not be satisfactory in aesthetically important areas. (medscape.com)