Adipose Tissue
Adipose Tissue, Brown
Adipose Tissue, White
Adipocytes
Obesity
Intra-Abdominal Fat
Lipolysis
Insulin Resistance
Leptin
Insulin
Thermogenesis
Adipocytes, White
3T3-L1 Cells
Mice, Obese
Fatty Acids
Lipid Metabolism
Adipokines
Body Weight
Omentum
Adiponectin
Lipoprotein Lipase
Dietary Fats
Fatty Acids, Nonesterified
Adiposity
Adipocytes, Brown
RNA, Messenger
Mitochondrial Proteins
Glycerol
Body Composition
Glucose
Panniculitis
Energy Metabolism
Liver
Epididymis
PPAR gamma
Muscle, Skeletal
Viscera
Lipids
Lipid Mobilization
Gene Expression Regulation
Abdominal Fat
Lipogenesis
Inflammation
Body Fat Distribution
Sterol Esterase
Body Temperature Regulation
Ion Channels
Buttocks
Lipodystrophy
Subcutaneous Tissue
Rats, Zucker
11-beta-Hydroxysteroid Dehydrogenase Type 1
Resistin
Thiazolidinediones
Gene Expression
Mice, Knockout
Receptors, Adrenergic, beta-3
Cell Differentiation
Fatty Acid Synthases
Reverse Transcriptase Polymerase Chain Reaction
Lipectomy
Glucose Tolerance Test
Body Mass Index
Lipase
Glucose Transporter Type 4
Thinness
Fatty Liver
Egg White
Pericardium
European Continental Ancestry Group
Rats, Wistar
Macrophages
Hormones, Ectopic
Carrier Proteins
Obesity, Morbid
Stearoyl-CoA Desaturase
Organ Specificity
Neoplasms, Adipose Tissue
Acetyl-CoA Carboxylase
Cells, Cultured
Swine
Anti-Obesity Agents
Glucose Clamp Technique
Diabetes Mellitus, Type 2
Mitochondria
Epinephrine
Metabolic Diseases
Glucose Intolerance
Tissue Distribution
Receptors, Leptin
Norepinephrine
Microdialysis
Proteins
Rats, Sprague-Dawley
Lipomatosis
Mice, Transgenic
Metabolic Syndrome X
Magnetic Resonance Imaging
Receptors, Adiponectin
Homeostasis
Real-Time Polymerase Chain Reaction
Aging
Biological Markers
Signal Transduction
HIV-Associated Lipodystrophy Syndrome
Interleukin-6
Tumor Necrosis Factor-alpha
Sterol Regulatory Element Binding Protein 1
1-Acylglycerol-3-Phosphate O-Acyltransferase
African Continental Ancestry Group
Nerve Fibers, Myelinated
Lipoma
Blotting, Western
Membrane Proteins
Rats, Inbred Strains
Angiopoietins
Hyperinsulinism
Transcription Factors
Oxygen Consumption
Linoleic Acids, Conjugated
Gene Expression Profiling
Gene Expression Regulation, Enzymologic
3T3 Cells
Cattle
Fats
Receptors, Cytoplasmic and Nuclear
Lactation
Random Allocation
Disease Models, Animal
Caloric Restriction
Sex Characteristics
Phenotype
Monosaccharide Transport Proteins
Receptors, Adrenergic, beta
Malate Dehydrogenase
Sheep
ATP Citrate (pro-S)-Lyase
Nicotinamide Phosphoribosyltransferase
Inflammation Mediators
Intercellular Signaling Peptides and Proteins
Stromal Cells
Stem Cells
Linoleic Acid
Isoproterenol
Growth Hormone
Cholesterol
Reference Values
Brain
Immunohistochemistry
Clenbuterol
Dietary Carbohydrates
Antigens, Differentiation, Myelomonocytic
Anthropometry
Lipodystrophy, Congenital Generalized
Pregnancy
Chemokine CCL2
Hormones
Uncoupling Agents
Fatty Acid-Binding Proteins
PPAR alpha
Mesenchymal Stromal Cells
Acetates
Diabetes Mellitus, Lipoatrophic
Fatty Acids, Unsaturated
Fatty Acid Synthase, Type I
Absorptiometry, Photon
Retinol-Binding Proteins, Plasma
Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. (1/644)
The Rb family, Rb, p107, and p130, play important roles in cell cycle control and cellular differentiation, and Rb has been suggested to regulate adipocyte differentiation. We report here that mice lacking p107 displayed a uniform replacement of white adipose tissue (WAT) with brown adipose tissue (BAT). Mutant WAT depots contained mutilocular adipocytes that expressed elevated levels of PGC-1alpha and UCP-1 typical of BAT. WAT from p107-/- mice contained markedly elevated numbers of adipogenic precursors that displayed downregulated expression of pRb. Consistent with the hypothesis that pRb is required for adult adipocyte differentiation, Cre-mediated deletion of Rb in adult primary preadipocytes blocked their differentiation into white adipocytes. Importantly, pRb was observed to bind the PGC-1alpha promoter and repress transcription. Therefore, p107 and pRb regulate PGC-1alpha expression to control the switch between white and brown adipocyte differentiation from a common pool of presumptive adult progenitors in fat tissue. (+info)Assessment of brown adipose tissue activity in rats by 99mTc-sestamibi uptake. (2/644)
Brown adipose tissue (BAT) physiology and imaging have recently attracted considerable attention. BAT is characterized both by enhanced perfusion and increased mitochondrial activity. (99m)Tc-sestamibi is a lipophilic cationic tracer that concentrates in mitochondria. Data on the accumulation of (99m)Tc-sestamibi in BAT are currently lacking. This study investigates the in vivo (99m)Tc-sestamibi uptake in rat BAT. (99m)Tc-sestamibi was administered in male Wistar rats of various age and body size. (99m)Tc-sestamibi uptake was measured in vitro in BAT and white fat (WF) together with cytochrome c oxidase activity. Both (99m)Tc-sestamibi uptake and cytochrome c oxidase activity were higher in BAT than in WF (P<0.05). (99m)Tc-Sestamibi uptake in both BAT and WF was negatively related to body weight (r = -0.96 and -0.89, respectively) as was the BAT/WF uptake ratio (r = -0.85). These data show a higher (99m)Tc-sestamibi uptake in BAT compared to WF, in agreement with the high mitochondrial content and respiratory activity of the former. The strong negative correlation between (99m)Tc-sestamibi uptake in BAT and body weight (negative allometry), is in accordance to increased needs of thermogenesis in smaller animals. Implications of increased (99m)Tc-sestamibi uptake in BAT in radionuclide imaging are also discussed. (+info)Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. (3/644)
In human obesity, white adipose tissue (WAT) is enriched in macrophages. How macrophage infiltration in WAT contributes to the complications of obesity is unknown. This study tested the hypothesis that recruitment of macrophages in omental WAT is associated with hepatic damage in obese patients. Paired biopsies of subcutaneous and omental WAT and a liver biopsy were collected during gastric surgery in 46 obese women and 9 obese men (BMI 47.9 +/- 0.93 kg/m(2)). The number of HAM56+ macrophages in WAT was quantified microscopically, and correlations with clinical and biological parameters and histological liver pathology were investigated. There were twice as many macrophages in omental as in subcutaneous WAT (P<0.0001). After adjustment for age, omental WAT macrophage infiltration was correlated to fasting glucose and insulin, quantitative insulin sensitivity check index, triglycerides, aspartate aminotransferase (AST), and gamma-glutamyltranspeptidase. We propose an easy equation to estimate the amount of macrophages in omental WAT. Increased macrophage accumulation specifically in omental WAT was associated with hepatic fibroinflammatory lesions (P=0.01). The best predictive model for the severity of hepatic damage includes adiponectinemia, AST, and omental WAT macrophages. These data suggest that the presence of macrophages in omental WAT participates in the cellular mechanisms favoring hepatic fibroinflammatory lesions in obese patients. (+info)Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue. (4/644)
Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid. Many people supplement their diets with CLAs to attempt weight loss, and the trans-10,cis-12 isomer (t10,c12-CLA) of CLA reduces adiposity in animal models and humans. However, CLA treatment in mice causes insulin resistance that has been attributed to the lipoatrophic state, which is associated with hyperinsulinemia and hepatic steatosis. Here, we investigated the effect of t10,c12-CLA on adipose tissue inflammation, another factor promoting insulin resistance. We confirmed that t10,c12-CLA daily gavage performed in mice reduces white adipose tissue (WAT) mass and adiponectin and leptin serum levels and provokes hyperinsulinemia. In parallel, we demonstrated that this CLA isomer led to a rapid induction of inflammatory factors such as tumor necrosis factor-alpha and interleukin-6 gene expression in WAT without affecting their serum levels. In vitro, t10,c12-CLA directly induced IL-6 secretion in 3T3-L1 adipocytes by an nuclear factor-kappaB-dependent mechanism. In vivo, however, the lipoatrophic adipose tissue of CLA-treated mice was notable for a dramatic increase in macrophage infiltration and gene expression. Thus, CLA supplementation directly induces inflammatory gene expression in adipocytes and also promotes macrophage infiltration into adipose tissue to a local inflammatory state that contributes to insulin resistance. (+info)Trans-10, cis-12 conjugated linoleic acid causes inflammation and delipidation of white adipose tissue in mice: a microarray and histological analysis. (5/644)
A combined histological and microarray analysis of the white adipose tissue (WAT) of mice fed trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) was performed to better define functional responses. Mice fed t10c12 CLA for 14 days lost 85% of WAT mass, 95% of adipocyte lipid droplet volume, and 15 or 47% of the number of adipocytes and total cells, respectively. Microarray profiling of replicated pools (n = 2 per day x diet) of control and treated mice (n = 140) at seven time points after 1-17 days of t10c12 CLA feeding found between 2,682 and 4,216 transcript levels changed by twofold or more. Transcript levels for genes involved in glucose and fatty acid import or biosynthesis were significantly reduced. Highly expressed transcripts for lipases were significantly reduced but still abundant. Increased levels of mRNAs for two key thermogenesis proteins, uncoupling protein 1 and carnitine palmitoyltransferase 1, may have increased energy expenditures. Significant reductions of mRNAs for major adipocyte regulatory factors, including peroxisome proliferator activated receptor-gamma, sterol regulatory binding protein 1, CAAT/enhancer binding protein-alpha, and lipin 1 were correlated with the reduced transcript levels for key metabolic pathways in the WAT. A prolific inflammation response was indicated by the 2- to 100-fold induction of many cytokine transcripts, including those for IL-6, IL-1beta, TNF ligands, and CXC family members, and an increased density of macrophages. The mRNA changes suggest that a combination of cell loss, increased energy expenditure, and residual transport of lipids out of the adipocytes may account for the cumulative mass loss observed. (+info)White adipose tissue: storage and effector site for environmental pollutants. (6/644)
White adipose tissue (WAT) represents a reservoir of lipophilic environmental pollutants, especially of those which are resistant to biological and chemical degradation - so-called persistent organic pollutants (POPs). Large amounts of different congeners and isomers of these compounds exhibit a variety of adverse biological effects. Interactions among different classes of compounds, frequently with opposing effects, complicate hazard evaluation and risk assessment. WAT is the key organ for energy homeostasis and it also releases metabolites into the circulation and adipokines with systemic effects on insulin sensitivity and fuel partitioning in muscles and other tissues. Its beneficial role is lost in obesity when excessive accumulation of WAT contributes to severe diseases, such as diabetes. POPs may crossroad or modulate the effect of endogenous ligands of nuclear transcription factors, participating in differentiation, metabolism and the secretory function of adipocytes. These mechanisms include, most importantly: i) endocrine disrupting potency of POPs mixtures on androgen, estrogen or thyroid hormone metabolism/functions in WAT, ii) interference of dioxin-like chemicals with retinoic acid homeostasis, where impact on retinoid receptors is expected, and iii) interaction with transcriptional activity of peroxisome proliferator-activated receptors is likely. Thus, the accumulation and action of POPs in WAT represents a unitary mechanism explaining, at least in part, the effects of POPs in the whole organism. By modulating WAT differentiation, metabolism and function, the POPs could affect not only the physiological role of WAT, but they may also influence the development of obesity-associated diseases. (+info)Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease. (7/644)
AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and (1)H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. (+info)Combined leptin actions on adipose tissue and hypothalamus are required to deplete adipocyte fat in lean rats: implications for obesity treatment. (8/644)
Intense hyperleptinemia completely depletes adipocyte fat of normal rats within 14 days. To determine the mechanism, epididymal fat pads from normal wild-type (+/+) and obese (fa/fa) Zucker Diabetic Fatty (ZDF) donor rats were transplanted into normal +/+ and fa/fa ZDF recipients. Hyperleptinemia induced by adenovirus-leptin administration depleted all fat from native fat pads and from fat transplants from +/+ donors but not from transplants from ZDF(fa/fa) donors with defective leptin receptors. In both native and transplanted +/+ fat pads, large numbers of mitochondria were apparent, and genes involved in fatty acid oxidation were up-regulated. However, +/+ fat pads transplanted into fa/fa recipients did not respond to hyperleptinemia, suggesting lack of an essential leptin-stimulated cohormone(s). In +/+ but not in fa/fa rats, plasma catecholamine levels rose, and both P-STAT3 and P-CREB increased in adipose tissue, suggesting that both direct and indirect (hypothalamic) leptin receptor-mediated actions of hyperleptinemia are involved in depletion of adipocyte fat. (+info)There are several different types of obesity, including:
1. Central obesity: This type of obesity is characterized by excess fat around the waistline, which can increase the risk of health problems such as type 2 diabetes and cardiovascular disease.
2. Peripheral obesity: This type of obesity is characterized by excess fat in the hips, thighs, and arms.
3. Visceral obesity: This type of obesity is characterized by excess fat around the internal organs in the abdominal cavity.
4. Mixed obesity: This type of obesity is characterized by both central and peripheral obesity.
Obesity can be caused by a variety of factors, including genetics, lack of physical activity, poor diet, sleep deprivation, and certain medications. Treatment for obesity typically involves a combination of lifestyle changes, such as increased physical activity and a healthy diet, and in some cases, medication or surgery may be necessary to achieve weight loss.
Preventing obesity is important for overall health and well-being, and can be achieved through a variety of strategies, including:
1. Eating a healthy, balanced diet that is low in added sugars, saturated fats, and refined carbohydrates.
2. Engaging in regular physical activity, such as walking, jogging, or swimming.
3. Getting enough sleep each night.
4. Managing stress levels through relaxation techniques, such as meditation or deep breathing.
5. Avoiding excessive alcohol consumption and quitting smoking.
6. Monitoring weight and body mass index (BMI) on a regular basis to identify any changes or potential health risks.
7. Seeking professional help from a healthcare provider or registered dietitian for personalized guidance on weight management and healthy lifestyle choices.
There are several factors that can contribute to the development of insulin resistance, including:
1. Genetics: Insulin resistance can be inherited, and some people may be more prone to developing the condition based on their genetic makeup.
2. Obesity: Excess body fat, particularly around the abdominal area, can contribute to insulin resistance.
3. Physical inactivity: A sedentary lifestyle can lead to insulin resistance.
4. Poor diet: Consuming a diet high in refined carbohydrates and sugar can contribute to insulin resistance.
5. Other medical conditions: Certain medical conditions, such as polycystic ovary syndrome (PCOS) and Cushing's syndrome, can increase the risk of developing insulin resistance.
6. Medications: Certain medications, such as steroids and some antipsychotic drugs, can increase insulin resistance.
7. Hormonal imbalances: Hormonal changes during pregnancy or menopause can lead to insulin resistance.
8. Sleep apnea: Sleep apnea can contribute to insulin resistance.
9. Chronic stress: Chronic stress can lead to insulin resistance.
10. Aging: Insulin resistance tends to increase with age, particularly after the age of 45.
There are several ways to diagnose insulin resistance, including:
1. Fasting blood sugar test: This test measures the level of glucose in the blood after an overnight fast.
2. Glucose tolerance test: This test measures the body's ability to regulate blood sugar levels after consuming a sugary drink.
3. Insulin sensitivity test: This test measures the body's ability to respond to insulin.
4. Homeostatic model assessment (HOMA): This is a mathematical formula that uses the results of a fasting glucose and insulin test to estimate insulin resistance.
5. Adiponectin test: This test measures the level of adiponectin, a protein produced by fat cells that helps regulate blood sugar levels. Low levels of adiponectin are associated with insulin resistance.
There is no cure for insulin resistance, but it can be managed through lifestyle changes and medication. Lifestyle changes include:
1. Diet: A healthy diet that is low in processed carbohydrates and added sugars can help improve insulin sensitivity.
2. Exercise: Regular physical activity, such as aerobic exercise and strength training, can improve insulin sensitivity.
3. Weight loss: Losing weight, particularly around the abdominal area, can improve insulin sensitivity.
4. Stress management: Strategies to manage stress, such as meditation or yoga, can help improve insulin sensitivity.
5. Sleep: Getting adequate sleep is important for maintaining healthy insulin levels.
Medications that may be used to treat insulin resistance include:
1. Metformin: This is a commonly used medication to treat type 2 diabetes and improve insulin sensitivity.
2. Thiazolidinediones (TZDs): These medications, such as pioglitazone, improve insulin sensitivity by increasing the body's ability to use insulin.
3. Sulfonylureas: These medications stimulate the release of insulin from the pancreas, which can help improve insulin sensitivity.
4. DPP-4 inhibitors: These medications, such as sitagliptin, work by reducing the breakdown of the hormone incretin, which helps to increase insulin secretion and improve insulin sensitivity.
5. GLP-1 receptor agonists: These medications, such as exenatide, mimic the action of the hormone GLP-1 and help to improve insulin sensitivity.
It is important to note that these medications may have side effects, so it is important to discuss the potential benefits and risks with your healthcare provider before starting treatment. Additionally, lifestyle modifications such as diet and exercise can also be effective in improving insulin sensitivity and managing blood sugar levels.
Body weight is an important health indicator, as it can affect an individual's risk for certain medical conditions, such as obesity, diabetes, and cardiovascular disease. Maintaining a healthy body weight is essential for overall health and well-being, and there are many ways to do so, including a balanced diet, regular exercise, and other lifestyle changes.
There are several ways to measure body weight, including:
1. Scale: This is the most common method of measuring body weight, and it involves standing on a scale that displays the individual's weight in kg or lb.
2. Body fat calipers: These are used to measure body fat percentage by pinching the skin at specific points on the body.
3. Skinfold measurements: This method involves measuring the thickness of the skin folds at specific points on the body to estimate body fat percentage.
4. Bioelectrical impedance analysis (BIA): This is a non-invasive method that uses electrical impulses to measure body fat percentage.
5. Dual-energy X-ray absorptiometry (DXA): This is a more accurate method of measuring body composition, including bone density and body fat percentage.
It's important to note that body weight can fluctuate throughout the day due to factors such as water retention, so it's best to measure body weight at the same time each day for the most accurate results. Additionally, it's important to use a reliable scale or measuring tool to ensure accurate measurements.
Symptoms of panniculitis may include pain, swelling, redness, and warmth in the affected area. In severe cases, the skin may become ulcerated and the condition can be accompanied by systemic symptoms such as fever and fatigue.
Panniculitis is often difficult to diagnose, as it can resemble other conditions such as cellulitis or abscesses. A skin biopsy is usually necessary to confirm the diagnosis. Treatment typically involves antibiotics if the condition is caused by an infection, and drainage of any fluid accumulation if there is an abscess. In some cases, surgical debridement may be necessary.
While panniculitis is generally not a life-threatening condition, it can be painful and disruptive to daily activities. It is important to seek medical attention if symptoms persist or worsen over time, as the condition can lead to complications such as infection of the bloodstream (sepsis) or tissue death (necrosis).
Panniculitis can occur at any age but is more common in children and young adults. It is also more prevalent in certain populations such as those with obesity, diabetes, or other chronic conditions that affect the skin.
In summary, panniculitis is a type of inflammation of the subcutaneous fat layer that can be caused by various factors and can present with symptoms such as pain, swelling, redness, and warmth in the affected area. While generally not life-threatening, it can be painful and disruptive to daily activities, and prompt medical attention is necessary for proper diagnosis and treatment.
There are several key features of inflammation:
1. Increased blood flow: Blood vessels in the affected area dilate, allowing more blood to flow into the tissue and bringing with it immune cells, nutrients, and other signaling molecules.
2. Leukocyte migration: White blood cells, such as neutrophils and monocytes, migrate towards the site of inflammation in response to chemical signals.
3. Release of mediators: Inflammatory mediators, such as cytokines and chemokines, are released by immune cells and other cells in the affected tissue. These molecules help to coordinate the immune response and attract more immune cells to the site of inflammation.
4. Activation of immune cells: Immune cells, such as macrophages and T cells, become activated and start to phagocytose (engulf) pathogens or damaged tissue.
5. Increased heat production: Inflammation can cause an increase in metabolic activity in the affected tissue, leading to increased heat production.
6. Redness and swelling: Increased blood flow and leakiness of blood vessels can cause redness and swelling in the affected area.
7. Pain: Inflammation can cause pain through the activation of nociceptors (pain-sensing neurons) and the release of pro-inflammatory mediators.
Inflammation can be acute or chronic. Acute inflammation is a short-term response to injury or infection, which helps to resolve the issue quickly. Chronic inflammation is a long-term response that can cause ongoing damage and diseases such as arthritis, asthma, and cancer.
There are several types of inflammation, including:
1. Acute inflammation: A short-term response to injury or infection.
2. Chronic inflammation: A long-term response that can cause ongoing damage and diseases.
3. Autoimmune inflammation: An inappropriate immune response against the body's own tissues.
4. Allergic inflammation: An immune response to a harmless substance, such as pollen or dust mites.
5. Parasitic inflammation: An immune response to parasites, such as worms or fungi.
6. Bacterial inflammation: An immune response to bacteria.
7. Viral inflammation: An immune response to viruses.
8. Fungal inflammation: An immune response to fungi.
There are several ways to reduce inflammation, including:
1. Medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease-modifying anti-rheumatic drugs (DMARDs).
2. Lifestyle changes, such as a healthy diet, regular exercise, stress management, and getting enough sleep.
3. Alternative therapies, such as acupuncture, herbal supplements, and mind-body practices.
4. Addressing underlying conditions, such as hormonal imbalances, gut health issues, and chronic infections.
5. Using anti-inflammatory compounds found in certain foods, such as omega-3 fatty acids, turmeric, and ginger.
It's important to note that chronic inflammation can lead to a range of health problems, including:
1. Arthritis
2. Diabetes
3. Heart disease
4. Cancer
5. Alzheimer's disease
6. Parkinson's disease
7. Autoimmune disorders, such as lupus and rheumatoid arthritis.
Therefore, it's important to manage inflammation effectively to prevent these complications and improve overall health and well-being.
Lipodystrophy can be caused by genetic mutations, hormonal imbalances, or certain medications. It can also be associated with other medical conditions such as metabolic disorders, endocrine problems, and neurological diseases.
The symptoms of lipodystrophy can vary depending on the type and severity of the condition. Common symptoms include:
1. Muscle wasting and weakness
2. Fat redistribution to certain areas of the body (such as the face, neck, and torso)
3. Metabolic problems such as insulin resistance and high blood sugar
4. Hormonal imbalances
5. Abnormal body shape and proportions
6. Poor wound healing
7. Easy bruising and bleeding
8. Increased risk of infections
9. Joint pain and stiffness
10. Mood changes such as depression, anxiety, and irritability
Treatment for lipodystrophy depends on the underlying cause of the condition. Medications, lifestyle modifications, and surgery may be used to manage symptoms and improve quality of life. In some cases, lipodystrophy can be a sign of an underlying medical condition that needs to be treated.
Lipodystrophy can have a significant impact on an individual's quality of life, affecting their physical appearance, self-esteem, and ability to perform daily activities. It is important to seek medical attention if symptoms persist or worsen over time. With proper diagnosis and treatment, individuals with lipodystrophy can improve their symptoms and overall health.
In medicine, thinness is sometimes used as a diagnostic criterion for certain conditions, such as anorexia nervosa or cancer cachexia. In these cases, thinness can be a sign of a serious underlying condition that requires medical attention.
However, it's important to note that thinness alone is not enough to diagnose any medical condition. Other factors, such as a person's overall health, medical history, and physical examination findings, must also be taken into account when making a diagnosis. Additionally, it's important to recognize that being underweight or having a low BMI does not necessarily mean that someone is unhealthy or has a medical condition. Many people with a healthy weight and body composition can still experience negative health effects from societal pressure to be thin.
Overall, the concept of thinness in medicine is complex and multifaceted, and it's important for healthcare providers to consider all relevant factors when evaluating a patient's weight and overall health.
There are several different types of weight gain, including:
1. Clinical obesity: This is defined as a BMI of 30 or higher, and is typically associated with a range of serious health problems, such as heart disease, type 2 diabetes, and certain types of cancer.
2. Central obesity: This refers to excess fat around the waistline, which can increase the risk of health problems such as heart disease and type 2 diabetes.
3. Muscle gain: This occurs when an individual gains weight due to an increase in muscle mass, rather than fat. This type of weight gain is generally considered healthy and can improve overall fitness and athletic performance.
4. Fat gain: This occurs when an individual gains weight due to an increase in body fat, rather than muscle or bone density. Fat gain can increase the risk of health problems such as heart disease and type 2 diabetes.
Weight gain can be measured using a variety of methods, including:
1. Body mass index (BMI): This is a widely used measure of weight gain that compares an individual's weight to their height. A BMI of 18.5-24.9 is considered normal, while a BMI of 25-29.9 is considered overweight, and a BMI of 30 or higher is considered obese.
2. Waist circumference: This measures the distance around an individual's waistline and can be used to assess central obesity.
3. Skinfold measurements: These involve measuring the thickness of fat at specific points on the body, such as the abdomen or thighs.
4. Dual-energy X-ray absorptiometry (DXA): This is a non-invasive test that uses X-rays to measure bone density and body composition.
5. Bioelectrical impedance analysis (BIA): This is a non-invasive test that uses electrical impulses to measure body fat percentage and other physiological parameters.
Causes of weight gain:
1. Poor diet: Consuming high amounts of processed foods, sugar, and saturated fats can lead to weight gain.
2. Lack of physical activity: Engaging in regular exercise can help burn calories and maintain a healthy weight.
3. Genetics: An individual's genetic makeup can affect their metabolism and body composition, making them more prone to weight gain.
4. Hormonal imbalances: Imbalances in hormones such as insulin, thyroid, and cortisol can contribute to weight gain.
5. Medications: Certain medications, such as steroids and antidepressants, can cause weight gain as a side effect.
6. Sleep deprivation: Lack of sleep can disrupt hormones that regulate appetite and metabolism, leading to weight gain.
7. Stress: Chronic stress can lead to emotional eating and weight gain.
8. Age: Metabolism slows down with age, making it more difficult to maintain a healthy weight.
9. Medical conditions: Certain medical conditions such as hypothyroidism, Cushing's syndrome, and polycystic ovary syndrome (PCOS) can also contribute to weight gain.
Treatment options for obesity:
1. Lifestyle modifications: A combination of diet, exercise, and stress management techniques can help individuals achieve and maintain a healthy weight.
2. Medications: Prescription medications such as orlistat, phentermine-topiramate, and liraglutide can aid in weight loss.
3. Bariatric surgery: Surgical procedures such as gastric bypass surgery and sleeve gastrectomy can be effective for severe obesity.
4. Behavioral therapy: Cognitive-behavioral therapy (CBT) and other forms of counseling can help individuals develop healthy eating habits and improve their physical activity levels.
5. Meal replacement plans: Meal replacement plans such as Medifast can provide individuals with a structured diet that is high in protein, fiber, and vitamins, and low in calories and sugar.
6. Weight loss supplements: Supplements such as green tea extract, garcinia cambogia, and forskolin can help boost weight loss efforts.
7. Portion control: Using smaller plates and measuring cups can help individuals regulate their portion sizes and maintain a healthy weight.
8. Mindful eating: Paying attention to hunger and fullness cues, eating slowly, and savoring food can help individuals develop healthy eating habits.
9. Physical activity: Engaging in regular physical activity such as walking, running, swimming, or cycling can help individuals burn calories and maintain a healthy weight.
It's important to note that there is no one-size-fits-all approach to treating obesity, and the most effective treatment plan will depend on the individual's specific needs and circumstances. Consulting with a healthcare professional such as a registered dietitian or a physician can help individuals develop a personalized treatment plan that is safe and effective.
There are two main types of fatty liver disease:
1. Alcoholic fatty liver disease (AFLD): This type of fatty liver disease is caused by excessive alcohol consumption and is the most common cause of fatty liver disease in the United States.
2. Non-alcoholic fatty liver disease (NAFLD): This type of fatty liver disease is not caused by alcohol consumption and is the most common cause of fatty liver disease worldwide. It is often associated with obesity, diabetes, and high cholesterol.
There are several risk factors for developing fatty liver disease, including:
* Obesity
* Physical inactivity
* High calorie intake
* Alcohol consumption
* Diabetes
* High cholesterol
* High triglycerides
* History of liver disease
Symptoms of fatty liver disease can include:
* Fatigue
* Abdominal discomfort
* Loss of appetite
* Nausea and vomiting
* Abnormal liver function tests
Diagnosis of fatty liver disease is typically made through a combination of physical examination, medical history, and diagnostic tests such as:
* Liver biopsy
* Imaging studies (ultrasound, CT or MRI scans)
* Blood tests (lipid profile, glucose, insulin, and liver function tests)
Treatment of fatty liver disease depends on the underlying cause and severity of the condition. Lifestyle modifications such as weight loss, exercise, and a healthy diet can help improve the condition. In severe cases, medications such as antioxidants, fibric acids, and anti-inflammatory drugs may be prescribed. In some cases, surgery or other procedures may be necessary.
Prevention of fatty liver disease includes:
* Maintaining a healthy weight
* Eating a balanced diet low in sugar and saturated fats
* Engaging in regular physical activity
* Limiting alcohol consumption
* Managing underlying medical conditions such as diabetes and high cholesterol.
Morbid obesity is typically defined as a BMI of 40 or higher, but some experts define it as a BMI of 35 or higher with one or more obesity-related health conditions, such as high blood pressure, type 2 diabetes, or sleep apnea.
Morbid obesity is different from simple obesity, which is defined as a BMI of 30 to 39. While simple obesity can also increase the risk of health problems, it is generally considered less severe than morbid obesity.
Morbid obesity is often treated with a combination of lifestyle changes, such as diet and exercise, and medications or surgery. In some cases, bariatric surgery may be recommended to help achieve and maintain weight loss.
It is important to note that BMI is not always an accurate measure of health, as it does not take into account muscle mass or body composition. However, it can provide a general indicator of whether an individual is at a healthy weight or if they are at risk for health problems due to their weight.
There are several types of adipocytic neoplasms, including:
1. Lipomas: These are benign, slow-growing tumors that are composed of mature fat cells (adipocytes). They are usually soft to the touch and can be moved easily under the skin.
2. Liposarcomas: These are malignant tumors that also originate in adipose tissue. They can be slow-growing or aggressive and can infiltrate surrounding tissues.
3. Pigmented villonodular synovitis (PVN): This is a type of benign tumor that occurs in the synovial membrane, which lines the joints and tendons. It is composed of adipocytes and other cell types and can cause pain and stiffness in the affected joint.
4. Giant cell lipomatosis: This is a rare condition characterized by multiple small lipomas that are clustered together.
5. Spindle cell lipoma: This is a rare type of lipoma that contains spindle-shaped cells, which are elongated and irregular in shape.
These adipocytic neoplasms can be diagnosed through various imaging techniques such as ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI), and fine needle aspiration biopsy. Treatment options vary depending on the type and location of the tumor, but may include surgical excision, radiation therapy, or chemotherapy.
There are many different approaches to weight loss, and what works best for one person may not work for another. Some common strategies for weight loss include:
* Caloric restriction: Reducing daily caloric intake to create a calorie deficit that promotes weight loss.
* Portion control: Eating smaller amounts of food and avoiding overeating.
* Increased physical activity: Engaging in regular exercise, such as walking, running, swimming, or weightlifting, to burn more calories and build muscle mass.
* Behavioral modifications: Changing habits and behaviors related to eating and exercise, such as keeping a food diary or enlisting the support of a weight loss buddy.
Weight loss can have numerous health benefits, including:
* Improved blood sugar control
* Reduced risk of heart disease and stroke
* Lowered blood pressure
* Improved joint health and reduced risk of osteoarthritis
* Improved sleep quality
* Boosted mood and reduced stress levels
* Increased energy levels
However, weight loss can also be challenging, and it is important to approach it in a healthy and sustainable way. Crash diets and other extreme weight loss methods are not effective in the long term and can lead to nutrient deficiencies and other negative health consequences. Instead, it is important to focus on making sustainable lifestyle changes that can be maintained over time.
Some common misconceptions about weight loss include:
* All weight loss methods are effective for everyone.
* Weight loss should always be the primary goal of a fitness or health program.
* Crash diets and other extreme weight loss methods are a good way to lose weight quickly.
* Weight loss supplements and fad diets are a reliable way to achieve significant weight loss.
The most effective ways to lose weight and maintain weight loss include:
* Eating a healthy, balanced diet that is high in nutrient-dense foods such as fruits, vegetables, whole grains, lean proteins, and healthy fats.
* Engaging in regular physical activity, such as walking, running, swimming, or weight training.
* Getting enough sleep and managing stress levels.
* Aiming for a gradual weight loss of 1-2 pounds per week.
* Focusing on overall health and wellness rather than just the number on the scale.
It is important to remember that weight loss is not always linear and can vary from week to week. It is also important to be patient and consistent with your weight loss efforts, as it can take time to see significant results.
Overall, weight loss can be a challenging but rewarding process, and it is important to approach it in a healthy and sustainable way. By focusing on overall health and wellness rather than just the number on the scale, you can achieve a healthy weight and improve your overall quality of life.
Type 2 diabetes can be managed through a combination of diet, exercise, and medication. In some cases, lifestyle changes may be enough to control blood sugar levels, while in other cases, medication or insulin therapy may be necessary. Regular monitoring of blood sugar levels and follow-up with a healthcare provider are important for managing the condition and preventing complications.
Common symptoms of type 2 diabetes include:
* Increased thirst and urination
* Fatigue
* Blurred vision
* Cuts or bruises that are slow to heal
* Tingling or numbness in the hands and feet
* Recurring skin, gum, or bladder infections
If left untreated, type 2 diabetes can lead to a range of complications, including:
* Heart disease and stroke
* Kidney damage and failure
* Nerve damage and pain
* Eye damage and blindness
* Foot damage and amputation
The exact cause of type 2 diabetes is not known, but it is believed to be linked to a combination of genetic and lifestyle factors, such as:
* Obesity and excess body weight
* Lack of physical activity
* Poor diet and nutrition
* Age and family history
* Certain ethnicities (e.g., African American, Hispanic/Latino, Native American)
* History of gestational diabetes or delivering a baby over 9 lbs.
There is no cure for type 2 diabetes, but it can be managed and controlled through a combination of lifestyle changes and medication. With proper treatment and self-care, people with type 2 diabetes can lead long, healthy lives.
Starvation is a condition where an individual's body does not receive enough nutrients to maintain proper bodily functions and growth. It can be caused by a lack of access to food, poverty, poor nutrition, or other factors that prevent the intake of sufficient calories and essential nutrients. Starvation can lead to severe health consequences, including weight loss, weakness, fatigue, and even death.
Types of Starvation:
There are several types of starvation, each with different causes and effects. These include:
1. Acute starvation: This occurs when an individual suddenly stops eating or has a limited access to food for a short period of time.
2. Chronic starvation: This occurs when an individual consistently does not consume enough calories and nutrients over a longer period of time, leading to gradual weight loss and other health problems.
3. Malnutrition starvation: This occurs when an individual's diet is deficient in essential nutrients, leading to malnutrition and other health problems.
4. Marasmus: This is a severe form of starvation that occurs in children, characterized by extreme weight loss, weakness, and wasting of muscles and organs.
5. Kwashiorkor: This is a form of malnutrition caused by a diet lacking in protein, leading to edema, diarrhea, and other health problems.
Effects of Starvation on the Body:
Starvation can have severe effects on the body, including:
1. Weight loss: Starvation causes weight loss, which can lead to a decrease in muscle mass and a loss of essential nutrients.
2. Fatigue: Starvation can cause fatigue, weakness, and a lack of energy, making it difficult to perform daily activities.
3. Weakened immune system: Starvation can weaken the immune system, making an individual more susceptible to illnesses and infections.
4. Nutrient deficiencies: Starvation can lead to a deficiency of essential nutrients, including vitamins and minerals, which can cause a range of health problems.
5. Increased risk of disease: Starvation can increase the risk of diseases such as tuberculosis, pellagra, and other infections.
6. Mental health issues: Starvation can lead to mental health issues such as depression, anxiety, and irritability.
7. Reproductive problems: Starvation can cause reproductive problems, including infertility and miscarriage.
8. Hair loss: Starvation can cause hair loss, which can be a sign of malnutrition.
9. Skin problems: Starvation can cause skin problems, such as dryness, irritation, and infections.
10. Increased risk of death: Starvation can lead to increased risk of death, especially in children and the elderly.
It is important to note that these effects can be reversed with proper nutrition and care. If you or someone you know is experiencing starvation, it is essential to seek medical attention immediately.
These diseases can cause a wide range of symptoms such as fatigue, weight changes, and poor wound healing. Treatment options vary depending on the specific condition but may include lifestyle changes, medications, or surgery.
1. Impaired glucose tolerance (IGT): This is a condition where the body has difficulty regulating blood sugar levels after consuming a meal.
2. Impaired fasting glucose (IFG): This is a condition where the body has difficulty regulating blood sugar levels when fasting (not eating for a period of time).
3. Gestational diabetes: This is a type of diabetes that develops during pregnancy, usually in the second or third trimester.
4. Type 2 diabetes: This is a chronic condition where the body cannot effectively use insulin to regulate blood sugar levels.
The symptoms of glucose intolerance can vary depending on the type and severity of the condition. Some common symptoms include:
* High blood sugar levels
* Increased thirst and urination
* Fatigue
* Blurred vision
* Cuts or bruises that are slow to heal
* Tingling or numbness in the hands and feet
The diagnosis of glucose intolerance is typically made through a combination of physical examination, medical history, and laboratory tests such as:
* Fasting plasma glucose (FPG) test: This measures the level of glucose in the blood after an overnight fast.
* Oral glucose tolerance test (OGTT): This measures the body's ability to regulate blood sugar levels after consuming a sugary drink.
* Hemoglobin A1c (HbA1c) test: This measures the average blood sugar level over the past 2-3 months.
Treatment for glucose intolerance usually involves lifestyle changes such as:
* Eating a healthy, balanced diet that is low in added sugars and refined carbohydrates
* Increasing physical activity to help the body use insulin more effectively
* Losing weight if you are overweight or obese
* Monitoring blood sugar levels regularly
In some cases, medication may be prescribed to help manage blood sugar levels. These include:
* Metformin: This is a type of oral medication that helps the body use insulin more effectively.
* Sulfonylureas: These medications stimulate the release of insulin from the pancreas.
* Thiazolidinediones: These medications improve the body's sensitivity to insulin.
If left untreated, glucose intolerance can lead to a range of complications such as:
* Type 2 diabetes: This is a more severe form of glucose intolerance that can cause damage to the body's organs and tissues.
* Cardiovascular disease: High blood sugar levels can increase the risk of heart disease and stroke.
* Nerve damage: High blood sugar levels over an extended period can damage the nerves, leading to numbness, tingling, and pain in the hands and feet.
* Kidney damage: High blood sugar levels can damage the kidneys and lead to kidney disease.
* Eye damage: High blood sugar levels can damage the blood vessels in the eyes, leading to vision problems.
It is important to note that not everyone with glucose intolerance will develop these complications, but it is important to manage the condition to reduce the risk of these complications occurring.
While lipomatosis is not a life-threatening condition, it can cause discomfort and pain due to the size and location of the lipomas. In some cases, lipomatosis may also lead to other health problems, such as obesity, joint pain, and sleep apnea.
There are several risk factors for developing lipomatosis, including:
* Genetics: Lipomatosis can be inherited from one's parents.
* Obesity: Excess weight is a major risk factor for developing lipomatosis.
* Hormonal changes: Changes in hormone levels, such as those that occur during pregnancy or menopause, can increase the risk of developing lipomatosis.
* Age: Lipomatosis is more common in adults over the age of 40.
* Gender: Women are more likely to develop lipomatosis than men.
There are several treatment options for lipomatosis, including:
* Liposuction: A surgical procedure that removes excess fat cells.
* Medications: Certain medications, such as corticosteroids and antidepressants, can help reduce the size of lipomas.
* Diet and exercise: Maintaining a healthy diet and exercise routine can help reduce body weight and alleviate symptoms of lipomatosis.
It is important to note that while lipomatosis is not a life-threatening condition, it can have a significant impact on a person's quality of life. If you suspect you may be experiencing symptoms of lipomatosis, it is important to consult with a healthcare professional for proper diagnosis and treatment.
1. Abdominal obesity (excess fat around the waistline)
2. High blood pressure (hypertension)
3. Elevated fasting glucose (high blood sugar)
4. High serum triglycerides (elevated levels of triglycerides in the blood)
5. Low HDL cholesterol (low levels of "good" cholesterol)
Having three or more of these conditions is considered a diagnosis of metabolic syndrome X. It is estimated that approximately 34% of adults in the United States have this syndrome, and it is more common in women than men. Risk factors for developing metabolic syndrome include obesity, lack of physical activity, poor diet, and a family history of type 2 diabetes or CVD.
The term "metabolic syndrome" was first introduced in the medical literature in the late 1980s, and since then, it has been the subject of extensive research. The exact causes of metabolic syndrome are not yet fully understood, but it is believed to be related to insulin resistance, inflammation, and changes in body fat distribution.
Treatment for metabolic syndrome typically involves lifestyle modifications such as weight loss, regular physical activity, and a healthy diet. Medications such as blood pressure-lowering drugs, cholesterol-lowering drugs, and anti-diabetic medications may also be prescribed if necessary. It is important to note that not everyone with metabolic syndrome will develop type 2 diabetes or CVD, but the risk is increased. Therefore, early detection and treatment are crucial in preventing these complications.
HALS typically involves the accumulation of fat in the face, neck, and torso, while the arms and legs become thin and wasted. This can lead to a characteristic "buffalo hump" appearance on the back of the neck and a "spare tire" around the waist. In addition to the cosmetic changes, HALS can also cause metabolic problems such as insulin resistance, high blood sugar, and high levels of lipids (fats) in the blood.
HIV-associated lipodystrophy syndrome is thought to be caused by a combination of factors, including genetics, hormonal imbalances, and side effects of certain HIV medications. Treatment for HALS typically involves a multidisciplinary approach, including lifestyle modifications such as diet and exercise, as well as medication therapy to manage metabolic abnormalities and reduce the risk of cardiovascular disease.
HIV-associated lipodystrophy syndrome is a significant health concern for individuals living with HIV, as it can increase the risk of other serious health problems such as heart disease and stroke. It is important for individuals infected with HIV to be aware of the risk of developing HALS and to work closely with their healthcare provider to manage this condition effectively.
There are many types of lipoma, with different names depending on their location and the tissues in which they grow. Common types include:
-Intramuscular lipoma: These occur within muscles and can feel firm or hard to the touch.
-Subcutaneous lipoma: These grow just beneath the skin and are usually soft to the touch.
-Mixed lipoma: These contain both fat cells and other types of tissue, such as muscle fibers.
-Spindle cell lipoma: These lipomas have a characteristic spindle or cylindrical shape under a microscope.
There are several ways to diagnose a lipoma, including physical examination, ultrasound imaging, and biopsy. Treatment for lipoma usually involves monitoring the tumor over time, as it will likely shrink or stay the same size without any intervention. However, if a lipoma grows quickly, becomes painful, or is causing discomfort or functional problems, surgical removal may be necessary.
In conclusion, lipomas are noncancerous growths that occur just beneath the skin or within muscles and connective tissues. They are usually painless unless pressed, but they can still cause discomfort or functional problems if large enough. While surgery is sometimes required to remove a lipoma, it is usually not necessary as long as the tumor remains small and doesn't grow rapidly over time.
In hyperinsulinism, the body produces too much insulin, leading to a range of symptoms including:
1. Hypoglycemia (low blood sugar): Excessive insulin can cause blood sugar levels to drop too low, leading to hypoglycemic symptoms such as shakiness, dizziness, confusion, and rapid heartbeat.
2. Weight gain: Hyperinsulinism can lead to weight gain due to the body's inability to effectively use glucose for energy production.
3. Fatigue: Excessive insulin can cause fatigue, as the body's cells are not able to effectively use glucose for energy production.
4. Mood changes: Hyperinsulinism can lead to mood changes such as irritability, anxiety, and depression.
5. Polycystic ovary syndrome (PCOS): Women with PCOS are at a higher risk of developing hyperinsulinism due to insulin resistance.
6. Gestational diabetes: Hyperinsulinism can occur during pregnancy, leading to gestational diabetes.
7. Acanthosis nigricans: A condition characterized by dark, velvety patches on the skin, often found in the armpits, neck, and groin area.
8. Cancer: Hyperinsulinism has been linked to an increased risk of certain types of cancer, such as breast, colon, and pancreatic cancer.
9. Cardiovascular disease: Excessive insulin can increase the risk of cardiovascular disease, including high blood pressure, heart disease, and stroke.
10. Cognitive impairment: Hyperinsulinism has been linked to cognitive impairment and an increased risk of dementia.
There are several causes of hyperinsulinism, including:
1. Insulin-producing tumors: Tumors that produce excessive amounts of insulin can lead to hyperinsulinism.
2. Familial hyperinsulinism: A genetic disorder that affects the regulation of insulin secretion and action.
3. Pancreatic beta-cell dysfunction: Dysfunction in the pancreatic beta cells, which produce insulin, can lead to hyperinsulinism.
4. Medications: Certain medications such as steroids and certain psychiatric drugs can cause hyperinsulinism.
5. Pituitary tumors: Tumors in the pituitary gland can lead to excessive secretion of growth hormone, which can stimulate insulin production.
6. Maternal diabetes during pregnancy: Women with diabetes during pregnancy may experience hyperinsulinism due to increased insulin resistance and higher insulin levels.
7. Gestational diabetes: High blood sugar during pregnancy can lead to hyperinsulinism.
8. Polycystic ovary syndrome (PCOS): Women with PCOS may experience hyperinsulinism due to insulin resistance and high insulin levels.
9. Cushing's syndrome: An endocrine disorder caused by excessive cortisol production can lead to hyperinsulinism.
10. Other medical conditions: Certain medical conditions such as thyroid disorders, adrenal gland disorders, and pituitary gland disorders can also cause hyperinsulinism.
It's important to note that some individuals with hyperinsulinism may not experience any symptoms, while others may experience a range of symptoms, including:
1. Weight gain
2. Fatigue
3. Headaches
4. Numbness or tingling in the hands and feet
5. Memory loss and difficulty concentrating
6. Mood changes, such as anxiety and depression
7. Skin problems, such as acne and thinning skin
8. Increased risk of heart disease and stroke
9. Growth retardation in children
10. Increased risk of developing type 2 diabetes
If you suspect that you or your child may have hyperinsulinism, it's important to consult with a healthcare professional for proper diagnosis and treatment. A doctor may perform a physical examination, take a medical history, and order blood tests to determine if hyperinsulinism is present and what may be causing it. Treatment options for hyperinsulinism will depend on the underlying cause of the condition. In some cases, medications such as metformin or other anti-diabetic drugs may be prescribed to help regulate blood sugar levels and reduce insulin production. In other cases, surgery or lifestyle changes may be necessary. With proper diagnosis and treatment, it is possible to manage hyperinsulinism and prevent or manage related health complications.
1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.
2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.
3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.
4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.
5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.
6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.
7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.
8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.
9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.
10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.
The term "lipodystrophy" refers to a group of conditions in which there is a loss or abnormal distribution of fat cells. Congenital generalized lipodystrophy is the most severe form of lipodystrophy and is usually diagnosed at birth or soon after.
The symptoms of CGL can vary depending on the severity of the condition, but may include:
1. Poor muscle tone (hypotonia)
2. Delayed development of motor skills
3. Fatigue and weakness
4. Poor appetite and growth delay
5. Abnormal fat distribution in the body
6. Metabolic problems, such as high blood sugar and insulin resistance
7. Increased risk of infections and other complications.
CGL is caused by mutations in genes that are important for adipose tissue development and function. There is currently no cure for CGL, but treatment may involve a combination of medication, nutritional support, and lifestyle modifications to manage the associated symptoms and complications.
The prognosis for individuals with CGL can vary depending on the severity of the condition and the presence of any additional health problems. However, with appropriate medical care and support, many individuals with CGL are able to lead active and fulfilling lives.
The exact cause of lipoatrophic diabetes mellitus is not fully understood, but it is believed to be related to an autoimmune response, where the body's immune system mistakenly attacks the insulin-producing cells in the pancreas. The condition is more common in males than females and typically affects adults between the ages of 20 and 40.
The diagnosis of lipoatrophic diabetes mellitus is based on a combination of clinical findings, laboratory tests, and imaging studies. Laboratory tests may include measurements of blood sugar levels, insulin levels, and antibodies against insulin or pancreatic cells. Imaging studies, such as CT scans or MRI scans, may be used to evaluate the pancreas and identify any damage to the insulin-producing cells.
Treatment of lipoatrophic diabetes mellitus typically involves a combination of insulin replacement therapy and lifestyle modifications such as a healthy diet and regular exercise. In some cases, medications such as metformin or sulfonylureas may be used to help improve insulin sensitivity. Regular monitoring of blood sugar levels and follow-up with a healthcare provider are also important to prevent complications associated with the condition.
In summary, lipoatrophic diabetes mellitus is a rare form of diabetes that is characterized by an insulin deficiency caused by the destruction of insulin-producing cells in the pancreas. The exact cause of the condition is not fully understood, but it is believed to be related to an autoimmune response. Treatment typically involves a combination of insulin replacement therapy and lifestyle modifications, and regular monitoring of blood sugar levels is important to prevent complications associated with the condition.
The exact cause of cachexia is not fully understood, but it is thought to be related to a combination of factors such as inflammation, hormonal imbalances, and changes in metabolism. Treatment for cachexia often focuses on addressing the underlying cause of the wasting, such as managing cancer or HIV/AIDS, as well as providing nutritional support and addressing any related complications.
In the medical field, cachexia is a serious condition that requires careful management to improve quality of life and outcomes for patients. It is important for healthcare providers to be aware of the signs and symptoms of cachexia and to provide appropriate treatment and support to affected individuals.
There are several ways to measure abdominal obesity, including:
1. Waist circumference: Measured by circling the natural waistline with a tape measure. Excess fat around the waistline is defined as a circumference of 35 inches or more for women and 40 inches or more for men.
2. Waist-to-hip ratio: Measured by dividing the circumference of the natural waistline by the circumference of the hips. A ratio of 0.8 or higher indicates abdominal obesity.
3. Body fat distribution: Measured using techniques such as dual-energy X-ray absorptiometry (DXA) or bioelectrical impedance analysis (BIA). These methods can estimate the amount of fat in various areas of the body, including the abdomen.
There are several factors that contribute to the development of abdominal obesity, including:
1. Genetics: Inheritance plays a role in the distribution of body fat, with some people more prone to accumulating fat around the midsection.
2. Poor diet: Consuming high amounts of processed foods, sugar, and saturated fats can contribute to weight gain and abdominal obesity.
3. Lack of physical activity: Sedentary lifestyle can lead to a decrease in muscle mass and an increase in body fat, including around the abdomen.
4. Age: As people age, their metabolism slows down, leading to weight gain and increased risk of obesity.
5. Hormonal imbalances: Certain hormonal imbalances, such as hypothyroidism or polycystic ovary syndrome (PCOS), can increase the risk of developing abdominal obesity.
Abdominal obesity is a significant health risk due to its association with various chronic diseases, including:
1. Type 2 diabetes: Excess fat around the abdominal area can lead to insulin resistance and increase the risk of developing type 2 diabetes.
2. Cardiovascular disease: Abdominal obesity is a major risk factor for heart disease, as excess fat in this area can increase the risk of high blood pressure, high cholesterol, and triglycerides.
3. Cancer: Studies have shown that central obesity is associated with an increased risk of certain types of cancer, including colon, breast, and pancreatic cancer.
4. Non-alcoholic fatty liver disease (NAFLD): Abdominal obesity can lead to the development of NAFLD, a condition characterized by fat accumulation in the liver, which can increase the risk of liver damage and other health complications.
5. Sleep apnea: Excess fat around the abdomen can increase the risk of sleep apnea, a condition characterized by pauses in breathing during sleep.
6. Respiratory problems: Abdominal obesity can increase the risk of respiratory problems, such as asthma and chronic obstructive pulmonary disease (COPD).
7. Osteoarthritis: Excess weight, particularly around the abdomen, can increase the risk of osteoarthritis in the knees and hips.
8. Mental health: Central obesity has been linked to an increased risk of depression and other mental health conditions.
9. Fertility problems: Abdominal obesity can affect fertility in both men and women, as excess fat can disrupt hormone levels and reduce the likelihood of conception.
10. Reduced life expectancy: Abdominal obesity is associated with a shorter life expectancy, as it increases the risk of various chronic diseases that can reduce lifespan.
Steatitis can cause a range of symptoms, including:
* Pain and tenderness in the affected area
* Swelling and redness
* Warmth to the touch
* Limited mobility or stiffness in the affected joint
* Fever
The exact cause of steatitis is not always clear, but it is thought to be related to changes in the body's metabolism and insulin resistance. In some cases, steatitis may be a side effect of certain medications or medical conditions, such as corticosteroid use or Cushing's syndrome.
There are several methods for diagnosing steatitis, including:
* Physical examination and medical history
* Imaging tests, such as X-rays or MRI scans
* Blood tests, such as lipase and amylase enzyme levels
Treatment for steatitis typically focuses on addressing the underlying cause of the condition. This may involve lifestyle changes, such as weight loss and exercise, as well as medication to manage related conditions like diabetes or high blood pressure. In some cases, surgery may be necessary to remove affected fat tissue.
In conclusion, steatitis is a condition characterized by inflammation of fat tissue that can cause pain, swelling, and limited mobility. It is often associated with obesity and metabolic disorders, and can be diagnosed through physical examination, imaging tests, and blood tests. Treatment typically focuses on addressing the underlying cause of the condition.
There are several types of hypertrophy, including:
1. Muscle hypertrophy: The enlargement of muscle fibers due to increased protein synthesis and cell growth, often seen in individuals who engage in resistance training exercises.
2. Cardiac hypertrophy: The enlargement of the heart due to an increase in cardiac workload, often seen in individuals with high blood pressure or other cardiovascular conditions.
3. Adipose tissue hypertrophy: The excessive growth of fat cells, often seen in individuals who are obese or have insulin resistance.
4. Neurological hypertrophy: The enlargement of neural structures such as brain or spinal cord due to an increase in the number of neurons or glial cells, often seen in individuals with neurodegenerative diseases such as Alzheimer's or Parkinson's.
5. Hepatic hypertrophy: The enlargement of the liver due to an increase in the number of liver cells, often seen in individuals with liver disease or cirrhosis.
6. Renal hypertrophy: The enlargement of the kidneys due to an increase in blood flow and filtration, often seen in individuals with kidney disease or hypertension.
7. Ovarian hypertrophy: The enlargement of the ovaries due to an increase in the number of follicles or hormonal imbalances, often seen in individuals with polycystic ovary syndrome (PCOS).
Hypertrophy can be diagnosed through various medical tests such as imaging studies (e.g., CT scans, MRI), biopsies, and blood tests. Treatment options for hypertrophy depend on the underlying cause and may include medications, lifestyle changes, and surgery.
In conclusion, hypertrophy is a growth or enlargement of cells, tissues, or organs in response to an excessive stimulus. It can occur in various parts of the body, including the brain, liver, kidneys, heart, muscles, and ovaries. Understanding the underlying causes and diagnosis of hypertrophy is crucial for effective treatment and management of related health conditions.
Types of Experimental Diabetes Mellitus include:
1. Streptozotocin-induced diabetes: This type of EDM is caused by administration of streptozotocin, a chemical that damages the insulin-producing beta cells in the pancreas, leading to high blood sugar levels.
2. Alloxan-induced diabetes: This type of EDM is caused by administration of alloxan, a chemical that also damages the insulin-producing beta cells in the pancreas.
3. Pancreatectomy-induced diabetes: In this type of EDM, the pancreas is surgically removed or damaged, leading to loss of insulin production and high blood sugar levels.
Experimental Diabetes Mellitus has several applications in research, including:
1. Testing new drugs and therapies for diabetes treatment: EDM allows researchers to evaluate the effectiveness of new treatments on blood sugar control and other physiological processes.
2. Studying the pathophysiology of diabetes: By inducing EDM in animals, researchers can study the progression of diabetes and its effects on various organs and tissues.
3. Investigating the role of genetics in diabetes: Researchers can use EDM to study the effects of genetic mutations on diabetes development and progression.
4. Evaluating the efficacy of new diagnostic techniques: EDM allows researchers to test new methods for diagnosing diabetes and monitoring blood sugar levels.
5. Investigating the complications of diabetes: By inducing EDM in animals, researchers can study the development of complications such as retinopathy, nephropathy, and cardiovascular disease.
In conclusion, Experimental Diabetes Mellitus is a valuable tool for researchers studying diabetes and its complications. The technique allows for precise control over blood sugar levels and has numerous applications in testing new treatments, studying the pathophysiology of diabetes, investigating the role of genetics, evaluating new diagnostic techniques, and investigating complications.
There are several types of diabetes mellitus, including:
1. Type 1 DM: This is an autoimmune condition in which the body's immune system attacks and destroys the cells in the pancreas that produce insulin, resulting in a complete deficiency of insulin production. It typically develops in childhood or adolescence, and patients with this condition require lifelong insulin therapy.
2. Type 2 DM: This is the most common form of diabetes, accounting for around 90% of all cases. It is caused by a combination of insulin resistance (where the body's cells do not respond properly to insulin) and impaired insulin secretion. It is often associated with obesity, physical inactivity, and a diet high in sugar and unhealthy fats.
3. Gestational DM: This type of diabetes develops during pregnancy, usually in the second or third trimester. Hormonal changes and insulin resistance can cause blood sugar levels to rise, putting both the mother and baby at risk.
4. LADA (Latent Autoimmune Diabetes in Adults): This is a form of type 1 DM that develops in adults, typically after the age of 30. It shares features with both type 1 and type 2 DM.
5. MODY (Maturity-Onset Diabetes of the Young): This is a rare form of diabetes caused by genetic mutations that affect insulin production. It typically develops in young adulthood and can be managed with lifestyle changes and/or medication.
The symptoms of diabetes mellitus can vary depending on the severity of the condition, but may include:
1. Increased thirst and urination
2. Fatigue
3. Blurred vision
4. Cuts or bruises that are slow to heal
5. Tingling or numbness in hands and feet
6. Recurring skin, gum, or bladder infections
7. Flu-like symptoms such as weakness, dizziness, and stomach pain
8. Dark, velvety skin patches (acanthosis nigricans)
9. Yellowish color of the skin and eyes (jaundice)
10. Delayed healing of cuts and wounds
If left untreated, diabetes mellitus can lead to a range of complications, including:
1. Heart disease and stroke
2. Kidney damage and failure
3. Nerve damage (neuropathy)
4. Eye damage (retinopathy)
5. Foot damage (neuropathic ulcers)
6. Cognitive impairment and dementia
7. Increased risk of infections and other diseases, such as pneumonia, gum disease, and urinary tract infections.
It is important to note that not all individuals with diabetes will experience these complications, and that proper management of the condition can greatly reduce the risk of developing these complications.
Definition: Hyperphagia is a condition characterized by excessive hunger and overeating, often seen in individuals with certain medical or psychiatric conditions.
More Information
Hyperphagia can be caused by a variety of factors, including:
* Hormonal imbalances, such as low levels of leptin or high levels of ghrelin
* Certain medications, such as steroids and some antidepressants
* Medical conditions, such as diabetes, hypothyroidism, and polycystic ovary syndrome (PCOS)
* Psychiatric conditions, such as binge eating disorder and other eating disorders
* Sleep deprivation or disruptions in the body's circadian rhythms
Symptoms of hyperphagia may include:
* Increased hunger and desire to eat
* Overeating or consuming large amounts of food
* Difficulty controlling food intake
* Feeling anxious or irritable when unable to eat
* Weight gain or obesity
Treatment for hyperphagia typically involves addressing the underlying cause, such as hormonal imbalances or psychiatric conditions. This may involve medication, therapy, or lifestyle changes. In some cases, weight loss strategies and nutrition counseling may also be helpful.
It is important to note that hyperphagia can have serious health consequences, including obesity, type 2 diabetes, and other metabolic disorders. If you suspect you or someone you know may be experiencing hyperphagia, it is important to seek medical attention to determine the cause and develop an appropriate treatment plan.
Being overweight can increase the risk of various health problems, such as heart disease, type 2 diabetes, high blood pressure, and certain types of cancer. It can also affect a person's mental health and overall quality of life.
There are several ways to assess whether someone is overweight or not. One common method is using the BMI, which is calculated based on height and weight. Another method is measuring body fat percentage, which can be done with specialized tools such as skinfold calipers or bioelectrical impedance analysis (BIA).
Losing weight and maintaining a healthy weight can be achieved through a combination of diet, exercise, and lifestyle changes. Some examples of healthy weight loss strategies include:
* Eating a balanced diet that is high in fruits, vegetables, whole grains, and lean protein sources
* Engaging in regular physical activity, such as walking, running, swimming, or weight training
* Avoiding fad diets and quick fixes
* Getting enough sleep and managing stress levels
* Setting realistic weight loss goals and tracking progress over time.
There are several possible causes of hyperglycemia, including:
1. Diabetes: This is a chronic condition where the body either does not produce enough insulin or cannot use insulin effectively.
2. Insulin resistance: This occurs when the body's cells become less responsive to insulin, leading to high blood sugar levels.
3. Pancreatitis: This is inflammation of the pancreas, which can lead to high blood sugar levels.
4. Cushing's syndrome: This is a rare hormonal disorder that can cause high blood sugar levels.
5. Medications: Certain medications, such as steroids and some types of antidepressants, can raise blood sugar levels.
6. Stress: Stress can cause the release of hormones such as cortisol and adrenaline, which can raise blood sugar levels.
7. Infections: Certain infections, such as pneumonia or urinary tract infections, can cause high blood sugar levels.
8. Trauma: Traumatic injuries can cause high blood sugar levels due to the release of stress hormones.
9. Surgery: Some types of surgery, such as heart bypass surgery, can cause high blood sugar levels.
10. Pregnancy: High blood sugar levels can occur during pregnancy, especially in women who have a history of gestational diabetes.
Hyperglycemia can cause a range of symptoms, including:
1. Increased thirst and urination
2. Fatigue
3. Blurred vision
4. Headaches
5. Cuts or bruises that are slow to heal
6. Tingling or numbness in the hands and feet
7. Dry, itchy skin
8. Flu-like symptoms, such as weakness, dizziness, and stomach pain
9. Recurring skin, gum, or bladder infections
10. Sexual dysfunction in men and women
If left untreated, hyperglycemia can lead to serious complications, including:
1. Diabetic ketoacidosis (DKA): A life-threatening condition that occurs when the body produces high levels of ketones, which are acidic substances that can cause confusion, nausea, and vomiting.
2. Hypoglycemia: Low blood sugar levels that can cause dizziness, confusion, and even loss of consciousness.
3. Nerve damage: High blood sugar levels over an extended period can damage the nerves, leading to numbness, tingling, and pain in the hands and feet.
4. Kidney damage: The kidneys may become overworked and damaged if they are unable to filter out the excess glucose in the blood.
5. Eye damage: High blood sugar levels can cause damage to the blood vessels in the eyes, leading to vision loss and blindness.
6. Cardiovascular disease: Hyperglycemia can increase the risk of cardiovascular disease, including heart attacks, strokes, and peripheral artery disease.
7. Cognitive impairment: Hyperglycemia has been linked to cognitive impairment and an increased risk of dementia.
It is essential to manage hyperglycemia by making lifestyle changes, such as following a healthy diet, regular exercise, and taking medication if prescribed by a healthcare professional. Monitoring blood sugar levels regularly can help identify the signs of hyperglycemia and prevent long-term complications.
White adipose tissue
Brown adipose tissue
Adipose tissue
Bone marrow adipose tissue
Leptin
Adipokine
NPC1
Lipid metabolism
Haptoglobin
Parathyroid gland
Human skin
Lipogenesis
Inflammation
TBX15
Mitochondrial dicarboxylate carrier
SMIM23
ZNF423
Bone morphogenetic protein
PRDM16
Dynapenia
ANGPTL8
Woods Hutchinson
CCAAT-enhancer-binding proteins
TREM2
FNDC5
Eleftheria Maratos-Flier
Fat-tailed dwarf lemur
SERCA
Interleukin 33
ILC2
Dormancy
Spinal cord
Obesity and fertility
DHRS7B
ACTH receptor
ABCA1
Lipid signaling
Obesogen
Endometrial cancer
Estrone
Hyperinsulinemia
Gynoid fat distribution
Barreleye
List of skin conditions
Lemur
Diazepam
Neuromere
Interleukin 6
CCR2
Perilipin-4
Fructolysis
Dromedary
Air pollution
Index of anatomy articles
Noggin (protein)
Woolly mammoth
Rudolph Leibel
Adipogenesis
The Heterogeneity of White Adipose Tissue | IntechOpen
Endoplasmic reticulum stress may be involved in insulin resistance and lipid metabolism disorders of the white adipose tissues...
Impaired white adipose tissue fatty acid metabolism in mice fed a high-fat diet worsened by arsenic exposure, primarily...
Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues | Communications...
Brown and white adipose tissue metabolism in obesity: stimulation by cold and meal ingestion - UTUPub
Ingrid Dahlman group | Karolinska Institutet
Search Results for Related Disciplines, Clinical Overview, Adipose tissue, Gland/Organ, White, Publication Details, Male | EDM...
Upregulation of Pluripotency Markers in Adipose Tissue-Derived Stem Cells by miR-302 and Leukemia Inhibitory Factor
Publications - Sushil G. Rane, Ph.D. - NIDDK
Strategies to Increase Filipino American Participation in Cardiovascular Health Promotion: A Systematic Review
DHEA: MedlinePlus Supplements
Salvianolic acid B plays an anti-obesity role in high fat diet-induced obese mice by regulating the expression of mRNA, circRNA...
Model Details
Search Results | Diabetes | American Diabetes Association
Tissue Survival | Harvard Catalyst Profiles | Harvard Catalyst
Fatty Acid Synthase/FASN Antibody (NB400-114): Novus Biologicals
Signalling role of adipose tissue: adipokines and inflammation in obesity | Biochemical Society Transactions | Portland Press
What is the fastest way to gain weight? - Dane101
Exipure Reviews - Shocking Exipure Weight Loss Pills Report - MarylandReporter.com
Exipure DR Lam Reviews: Real Scam Complaints? - IPS Inter Press Service Business
Targeted Nanoparticle Therapy Seen to Assist Weight Loss
Scientific Publishing: A new twist on peer review | eLife
Project Investigators - University of Mississippi Medical Center
Comprehensive Metabolic Profiling Reveals a Lipid-Rich Fingerprint of Free Thyroxine Far Beyond Classic Parameters, Journal of...
Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues | BMC...
WHO EMRO | Obesity-linked diabetes in the Arab world: a review | Volume 21, issue 6 | EMHJ volume 21, 2015
TCDB » SEARCH
Could coffee be the secret to fighting obesity? - Neuroscience News
Epididymal white adipos2
- Illumina Hiseq 4000 was used to study the effects of Sal B on the expression of long non-coding RNA (lncRNA) and circular RNA (circRNA) in epididymal white adipose tissue induced by a high fat diet in obese mice. (nih.gov)
- We investigated the dynamic changes of liver gene expression and serum parameters of mice at several time points during a 48 hour fasting experiment and then focused on the global gene expression changes in epididymal white adipose tissue (WAT) as well as on pathways common to WAT, liver, and skeletal muscle. (biomedcentral.com)
Visceral3
- Accumulation of visceral white adipose tissue (WAT) leads to central obesity and is associated with insulin resistance and increased risk of metabolic disease, whereas accumulation of subcutaneous WAT leads to peripheral obesity and may be protective of metabolic syndrome. (intechopen.com)
- Visceral adipose tissue (VAT) accumulation is considered more detrimental to metabolic health compared to SAT. Discovering what changes occur in VAT metabolism in obesity, and after weight loss, could help elucidate the role of VAT in metabolic disease. (utupub.fi)
- PCOS and COVID-19 relationship", publicado na Rev Endocr Metab aumento do tecido adiposo visceral. (bvsalud.org)
Abdominal adipose tissue4
- The group conducts research on genetics and studies how human abdominal adipose tissue contributes to obesity-related complications and insulin resistance. (ki.se)
- Besides genetics, the focus of Ingrid´s research is how human abdominal adipose tissue contributes to obesity-related complications and insulin resistance. (ki.se)
- In the single dose experiments, selected hens were killed at various times ranging from 1 hour up to 28 days after dosing and abdominal adipose tissue was removed and assayed for leptophos. (cdc.gov)
- The necrosis extended into all the abdominal adipose tissue at the rectus abdominis muscle and linea alba. (cdc.gov)
Subcutaneous adipose tissue2
- Increased subcutaneous adipose tissue (SAT) perfusion after a meal is reduced in obesity, leading to the accumulation of ectopic fat, increasing the risk of type 2 diabetes (T2D). (utupub.fi)
- Measures of subcutaneous adipose tissue are important because individuals with large values are reported to be at increased risks for hypertension, adult-onset diabetes mellitus, cardiovascular disease, gallstones, arthritis, and other disease, and forms of cancer. (cdc.gov)
Metabolism11
- Adipose tissue not only stores energy, but also controls metabolism through secretion of hormones, cytokines, proteins, and microRNAs that affect the function of cells and tissues throughout the body. (intechopen.com)
- Glucose and lipid metabolism are closely linked in white adipose tissue (WAT), yet the underlying mechanisms of the effect of iTFAs in WAT are poorly understood. (whiterose.ac.uk)
- Impaired white adipose tissue fatty acid metabolism in mice fed a high-fat diet worsened by arsenic exposure, primarily affecting retroperitoneal adipose tissue. (bvsalud.org)
- Fatty acid (FA) metabolism dysfunction of white adipose tissue (WAT) underlies obesity and insulin resistance in response to high calorie intake and/or endocrine-disrupting chemicals (EDCs), among other factors. (bvsalud.org)
- Overall, our findings shed light on the role that the white adipose tissue, which lies at the crossroads of nutrition, metabolism and immunity, may play in influenza infection. (nature.com)
- Adipose tissue (AT) metabolism is dysregulated in obesity. (utupub.fi)
- Reduced brown adipose tissue (BAT) glucose uptake during cold exposure is associated with obesity and insulin resistance, but the role of fatty acids in human BAT metabolism is unclear. (utupub.fi)
- For this purpose we have access to a unique cohort with details of abdominal adipose morphology and metabolism determined in 950 adults. (ki.se)
- If you often suffer from bloating, slowed down energy and pace, poor mood, increased appetite, and cravings, you should know that your body has a poor metabolism due to the lack of brown adipose tissues. (ipsnews.net)
- Exipure DR Lam is designed in such a way that it targets the root cause (lack of BAT- brown adipose tissues) and ensures your metabolism works faster than ever before. (ipsnews.net)
- 2021). Emodin Improves Glucose and Lipid Metabolism Disorders in Obese Mice Activating Brown Adipose Tissue and Inducing Browning of White Adipose Tissue. (tcdb.org)
Retroperitoneal adipose1
- The expression of glucose-regulated protein 78 (GRP78) and the phosphorylation of inositol-requiring enzyme 1-alpha and c-Jun N-terminal kinase (JNK) were significantly increased in subcutaneous and retroperitoneal adipose depots of HFD-M-fed rats. (whiterose.ac.uk)
Induces1
- The authors conclude that leptophos is readily absorbed by the adipose tissue of hens and induces delayed neurotoxicity. (cdc.gov)
Metabolic1
- Adipose tissue plays a central role in obesity-related metabolic diseases such as type 2 diabetes. (nih.gov)
Accumulation2
Type 2 diabet1
- The aim of our research is to define genetic variants acting in adipose tissue to influence risk of abdominal obesity and type 2 diabetes. (ki.se)
Fatty1
- Fatty tissue composed of WHITE ADIPOCYTES and generally found directly under the skin (SUBCUTANEOUS FAT) and around the internal organs (ABDOMINAL FAT). (bvsalud.org)
Adipocytes3
- While much attention has been paid to identifying differences between white, brown and brite/beige adipocytes, there is growing evidence that there is functional heterogeneity among white adipocytes themselves. (intechopen.com)
- Retroperitoneal was the WAT most affected, where the combination of arsenic and HFD in contrast to HFD, generated higher adipose weight, larger adipocytes , increased triglyceride content, and decreased fasting stimulated lipolysis evidenced by lower phosphorylation of HSL and perilipin . (bvsalud.org)
- These hyphae extended toward the hypodermic fat tissues and were associated with a break in the cell membrane of adipocytes and with crystals inside the adipocytes. (cdc.gov)
Differentiation1
- Other pathways may play an important role in the formation and differentiation of adipose tissue, such as B cell receptor signaling. (nih.gov)
Inflammation2
- Human adipose tissue expresses interleukin-6, a cytokine that activates the production of C-reactive protein from the liver, potentially inducing low-grade systemic inflammation in persons with excess body fat. (who.int)
- Obesity is characterized by a state of chronic mild inflammation, with raised circulating levels of inflammatory markers and the expression and release of inflammation-related adipokines generally rises as adipose tissue expands (adiponectin, which has anti-inflammatory action is an exception). (portlandpress.com)
Depots2
- Adipose tissue is organized in discrete depots in specific locations throughout the body. (intechopen.com)
- We will introduce the major different WAT depots and more fully elaborate the physiology of two more recently defined depots: the dermal and bone marrow adipose tissue. (intechopen.com)
Excess4
- The prevalence of obesity, characterized by excess of adipose tissue, has been increasing worldwide and represents one of the most significant public health problems of our time. (intechopen.com)
- Once there's an adequate supply of BAT in the body, it naturally burns the excess deposit of white fat and helps you gain the much adorned leaner shape. (marylandreporter.com)
- You may be aware of the functioning of white fat tissues - it stores calories in the form of fat which appears around the body as excess flab. (marylandreporter.com)
- Its main function is to generate body heat by burning calories (as opposed to white fat, which is a result of storing excess calories). (neurosciencenews.com)
Targets2
- Exipure tropical loophole targets BAT or Brown Adipose Tissues. (marylandreporter.com)
- Researchers hope to find more specific adipose tissue targets that could lessen the possibility of side effects. (pharmacytimes.com)
Thermogenesis1
- Caffeine can promote brown adipose tissue function and improve thermogenesis, helping to burn fat more efficiently. (neurosciencenews.com)
Organ2
- The span of viability of a tissue or an organ. (harvard.edu)
- White adipose tissue (WAT) is a major endocrine and secretory organ, which releases a wide range of protein signals and factors termed adipokines. (portlandpress.com)
Contrast2
- In contrast, brown adipose tissues burn fat to release heat. (marylandreporter.com)
- In contrast to white anatomy, the Asian eyelid has more fullness of the upper eyelid, narrower palpebral fissures, medial epicanthal folds, and a lid crease closer to the eyelid margin. (medscape.com)
Descriptor1
- Tissue Survival" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Malignant1
- The goal of surgical treatment of basal cell carcinoma (BCC) is to destroy or remove the tumor so that no malignant tissue is allowed to proliferate further. (medscape.com)
Glucose1
- Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1). (neurosciencenews.com)
Concentrations4
- In 6 month old hens given 250mg/kg leptophos, peak adipose tissue leptophos concentrations of 25.1 parts per million (ppm) occurred 1 day after dosing. (cdc.gov)
- In 21 month old hens given 250mg/kg leptophos adipose tissue concentrations averaged 9.52ppm 1 day after dosing, decreasing slowly thereafter. (cdc.gov)
- Adipose tissue leptophos concentrations in hens given 5 or 10mg/kg increased progressively for 21 days, decreasing slowly thereafter. (cdc.gov)
- In birds given 20mg/kg daily, adipose tissue leptophos concentrations increased slowly for 14 days, then rose rapidly thereafter. (cdc.gov)
Infection2
- However, the impact of influenza infection on white adipose tissue (WAT), a key tissue in the control of systemic energy homeostasis, has not been yet characterized. (nature.com)
- Persistence of necrotic tissues at the infection site required additional surgical debridement on day 10. (cdc.gov)
Brown18
- This chapter will briefly introduce the two major types of fat, brown and white. (intechopen.com)
- TGF-β/Smad3 Signaling Regulates Brown Adipocyte Induction in White Adipose Tissue. (nih.gov)
- There are two types of body fat: white adipose tissue (WAT) and brown adipose tissue (BAT). (dane101.com)
- Brown fat is a lesser-known cousin of white fat. (marylandreporter.com)
- Their function is to provide heat to the body, and that's why young ones have heaps of brown adipose tissues - they help the babies stay warm. (marylandreporter.com)
- Due to the fat-burning capabilities of brown adipose tissues, they are being touted as the secret weapon against extra fat. (marylandreporter.com)
- And, we have learned that a higher proportion of brown adipose tissues means extra fat burning, more heat, and less weight. (marylandreporter.com)
- Exipure DR Lam is formulated to fight the root cause of obesity in men and women: low brown adipose tissue levels. (ipsnews.net)
- This formula helps your body create more brown adipose tissue so your body can naturally burn more fats. (ipsnews.net)
- As per a report and study published in 2021, many scientists have finally agreed to the fact that the root cause of obesity is low brown adipose tissue levels. (ipsnews.net)
- This is done by the brown tissues. (ipsnews.net)
- The brown adipose tissues get their brown color from dense mitochondria that mainly work to shrink and burn fat 24 x 7 . (ipsnews.net)
- It has been proven to boost the brown adipose tissues to help your body shrink more fats. (ipsnews.net)
- Like other ingredients, holy basil being a herb helps detoxify the cells and improve the brown adipose tissues composition to help you melt more fat. (ipsnews.net)
- Also known as Olea Europaea, this ingredient helps improve the quantity of BAT (brown adipose tissue) that helps the fat to shrink from fat cells. (ipsnews.net)
- These drugs turn white adipose tissue into brown adipose tissue that burns fat and also stimulates the growth of new blood vessels (angiogenesis) in fat tissue. (pharmacytimes.com)
- This helps the nanoparticle target cells and helps in turning white tissue brown. (pharmacytimes.com)
- Brown adipose tissue (BAT), also known as brown fat, is one of two types of fat found in humans and other mammals. (neurosciencenews.com)
Dysfunction1
- Tissue-based markers of right ventricular dysfunction in ischemic mitral regurgitation assessed via stress cardiac magnetic resonance and three-dimensional echocardiography. (harvard.edu)
Bone1
- Anthropometry is the study of the measurement of the human body in terms of the dimensions of bone, muscle, and adipose (fat) tissue. (cdc.gov)
Accumulate1
- This can be very dangerous for your overall health as the lack of these tissues can force the body to accumulate more fat. (ipsnews.net)
Body1
- This is a proof-of-concept approach for selectively targeting the white adipose tissue and 'browning it' to allow the body to burn fat. (pharmacytimes.com)
Clinical1
- White adipose tissue represents a rich source of stem cells with potential applications in basic and clinical research. (hindawi.com)
Hypertension1
- Research shows that FAs are 18% more likely to have hypertension than other Asians or whites (4). (cdc.gov)
Liver1
- May see 1 or 2 minor cross-reacting lower MW bands in liver tissue. (novusbio.com)
Examination of the tissue2
- Tumors that are aggressive and those occurring near vital or cosmetically sensitive structures are best treated with methods that allow for an examination of the tissue margins. (medscape.com)
- A diagnosis of zygomycosis was made after direct examination and histopathologic examination of the tissue samples. (cdc.gov)
Dose2
- In the multiple dose experiment the hens were killed after the last dose and the adipose tissue was analyzed for leptophos as before. (cdc.gov)
- Using target tissue, dose estimates, instead of external or criteria and a thorough and efficient review process can reduce the applied doses, can improve the characterization of dose-response number of review and revision iterations and hence the time needed relationship and subsequent characterization of potential health to prepare a model for application. (cdc.gov)
Prevalence1
- FA engagement in health promotion is critical because FAs continue to have a higher prevalence of chronic diseases than whites, blacks, and other Asian groups (3-6). (cdc.gov)
Mice2
- ADSCs were isolated from the inguinal adipose tissue of 10-12-week-old Balb/c mice using 2 mg/mL collagenase A (Roche, Mannheim, Germany) digestion, as previously described [ 9 ]. (hindawi.com)
- A recent study used nanoparticles to deliver antiobesity drugs directly into the fat tissue in overweight mice models. (pharmacytimes.com)
Markers3
- The expression pattern of pluripotency markers in adipose tissue-derived stem cells (ADSCs) is a subject of controversy. (hindawi.com)
- These findings showed that mouse adipose tissue contains a population of cells with molecular resemblance to embryonic stem cells, and LIF and miR-302 family positively affect the expression of pluripotency markers. (hindawi.com)
- Diverse Approaches to Ovarian Tissue Cryopreservation Have Equivalent Outcomes in Markers of Tissue Viability. (harvard.edu)
Role4
- However, the role of Sal B in white adipose tissue (WAT) is not yet clear. (nih.gov)
- Role of 3-Dimensional Architecture of Scar and Surviving Tissue in Ventricular Tachycardia: Insights From High-Resolution Ex Vivo Porcine Models. (harvard.edu)
- Leptin is produced by white adipose tissue and has a prominent role in regulating appetite and energy expenditure via its actions in the hypothalamus. (umc.edu)
- Thyroid hormones (THs), with triiodothyronine (T3) and thyroxine (T4) as the major secretion products of the thyroid gland, play a vital role in the human organism owing to the substantial expression of their corresponding nuclear receptors in almost all tissues (1). (deepdyve.com)
Surgical2
- Preconditioning of surgical pedicle flaps with DNA plasmid expressing hypoxia-inducible factor-1a (HIF-1a) promotes tissue viability. (harvard.edu)
- These features are all evaluated in the assessment of the upper eyelid and in the planning for surgical procedures to alter the periorbital tissue. (medscape.com)
Diabetes2
Energy1
- White fat provides heat insulation, mechanical cushion, and source of energy. (bvsalud.org)
Cells4
- Adipose tissue-derived stem cells (ADSCs) can be harvested from patients by a simple and minimally invasive method. (hindawi.com)
- Isolated cells were counted and plated at 5 × 10 4 cells/mL seeding density in 6 cm tissue culture plates and cultured in Dulbecco's modified eagle's medium (DMEM, Gibco, Life Technologies, USA) with 20% fetal bovine serum (FBS, Gibco). (hindawi.com)
- Flow Cytometry Assisted Isolation of Adipose Tissue Derived Stem Cells. (nih.gov)
- It rejuvenates and repairs aging cells so your skin, cells, tissues, and muscles remain fresh and active. (ipsnews.net)
Muscle1
- Plasma, muscle, and adipose samples will be subjected to global transcriptome and metabolomic analyses. (ki.se)
Samples1
- Culture of tissues samples on Sabouraud-chloramphenicol-gentamicin agar after 4 days at 30°C and 37°C grew a white aerial mold, which covered the entire surface of the agar. (cdc.gov)
Major1
- This graph shows the total number of publications written about "Tissue Survival" by people in Harvard Catalyst Profiles by year, and whether "Tissue Survival" was a major or minor topic of these publication. (harvard.edu)
Skin1
- [ 2 ] In addition to standard suture techniques, tissue adhesives have also been used for skin closure. (medscape.com)
Important1
- Finally, healing by secondary intention (granulation) often leads to atrophic white scars that may not be satisfactory in aesthetically important areas. (medscape.com)