Adiponectin
A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.
Receptors, Adiponectin
Cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin.
Leptin
Insulin Resistance
Resistin
Adipokines
Intercellular Signaling Peptides and Proteins
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Adipocytes
Obesity
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Adipose Tissue
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
3T3-L1 Cells
Body Mass Index
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Metabolic Syndrome X
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
PPAR gamma
Adiposity
AMP-Activated Protein Kinases
Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.
Thiazolidinediones
Intra-Abdominal Fat
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
C-Reactive Protein
Adenylate Kinase
Mice, Obese
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Risk Factors
Lipids
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Glucose Tolerance Test
Body Composition
Body Weight
Inflammation
Hormones, Ectopic
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Adipose Tissue, White
Fatty Liver
Waist Circumference
Abdominal Fat
Waist-Hip Ratio
The waist circumference measurement divided by the hip circumference measurement. For both men and women, a waist-to-hip ratio (WHR) of 1.0 or higher is considered "at risk" for undesirable health consequences, such as heart disease and ailments associated with OVERWEIGHT. A healthy WHR is 0.90 or less for men, and 0.80 or less for women. (National Center for Chronic Disease Prevention and Health Promotion, 2004)
HEK293 Cells
Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity. (1/2639)
Obesity which is defined as accumulation of excess body fat, is a major cause of atherosclerotic vascular disease in industrial countries. Recent advances in the biology of adipose tissue have revealed that adipose tissue is not simply an energy storage organ but it also secretes a variety of molecules which affect the metabolism of the whole body. Through a systematic search of active genes in adipose tissue, we found that adipose tissue, especially visceral fat expressed numerous genes for secretory proteins (about 30% of total genes analyzed). Among them, plasminogen activator-1 (PAI-1), which is a regulator of the fibrinolytic system, was overexpressed in the visceral fat in an animal model of obesity. Plasma levels of PAI-1 were closely correlated with visceral fat adiposity. Thus, PAI-1 secreted from visceral fat may play some role in thrombotic vascular disease in visceral obesity. Adiponectin, a novel adipose-specific gene product, which has a matrix-like structure, is abundantly present in the bloodstream. Dysregulated secretion of adiponectin may be related to vascular disease in obesity. Biologically active molecules secreted from adipose tissue (adipocytokines) may have important roles in the development of atherosclerotic disease in obesity. (+info)Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. (2/2639)
Insulin stimulates adipose cells both to secrete proteins and to translocate the GLUT4 glucose transporter from an intracellular compartment to the plasma membrane. We demonstrate that whereas insulin stimulation of 3T3-L1 adipocytes has no effect on secretion of the alpha3 chain of type VI collagen, secretion of the protein hormone adipocyte complement related protein of 30 kD (ACRP30) is markedly enhanced. Like GLUT4, regulated exocytosis of ACRP30 appears to require phosphatidylinositol-3-kinase activity, since insulin-stimulated ACRP30 secretion is blocked by pharmacologic inhibitors of this enzyme. Thus, 3T3-L1 adipocytes possess a regulated secretory compartment containing ACRP30. Whether GLUT4 recycles to such a compartment has been controversial. We present deconvolution immunofluorescence microscopy data demonstrating that the subcellular distributions of ACRP30 and GLUT4 are distinct and nonoverlapping; in contrast, those of GLUT4 and the transferrin receptor overlap. Together with supporting evidence that GLUT4 does not recycle to a secretory compartment via the trans-Golgi network, we conclude that there are at least two compartments that undergo insulin-stimulated exocytosis in 3T3-L1 adipocytes: one for ACRP30 secretion and one for GLUT4 translocation. (+info)Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. (3/2639)
BACKGROUND: Among the many adipocyte-derived endocrine factors, we recently found an adipocyte-specific secretory protein, adiponectin, which was decreased in obesity. Although obesity is associated with increased cardiovascular mortality and morbidity, the molecular basis for the link between obesity and vascular disease has not been fully clarified. The present study investigated whether adiponectin could modulate endothelial function and relate to coronary disease. METHODS AND RESULTS: For the in vitro study, human aortic endothelial cells (HAECs) were preincubated for 18 hours with the indicated amount of adiponectin, then exposed to tumor necrosis factor-alpha (TNF-alpha) (10 U/mL) or vehicle for the times indicated. The adhesion of human monocytic cell line THP-1 cells to HAECs was determined by adhesion assay. The surface expression of vascular cell adhesion molecule-1 (VCAM-1), endothelial-leukocyte adhesion molecule-1 (E-selectin), and intracellular adhesion molecule-1 (ICAM-1) was measured by cell ELISA. Physiological concentrations of adiponectin dose-dependently inhibited TNF-alpha-induced THP-1 adhesion and expression of VCAM-1, E-selectin, and ICAM-1 on HAECs. For the in vivo study, the concentrations of adiponectin in human plasma were determined by a sandwich ELISA system that we recently developed. Plasma adiponectin concentrations were significantly lower in patients with coronary artery disease than those in age- and body mass index-adjusted control subjects. CONCLUSIONS: These observations suggest that adiponectin modulates endothelial inflammatory response and that the measurement of plasma adiponectin levels may be helpful in assessment of CAD risk. (+info)Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. (4/2639)
Adiponectin is a novel, adipose-specific protein abundantly present in the circulation, and it has antiatherogenic properties. We analyzed the plasma adiponectin concentrations in age- and body mass index (BMI)-matched nondiabetic and type 2 diabetic subjects with and without coronary artery disease (CAD). Plasma levels of adiponectin in the diabetic subjects without CAD were lower than those in nondiabetic subjects (6.6+/-0.4 versus 7.9+/-0.5 microg/mL in men, 7.6+/-0.7 versus 11.7+/-1.0 microg/mL in women; P<0.001). The plasma adiponectin concentrations of diabetic patients with CAD were lower than those of diabetic patients without CAD (4.0+/-0.4 versus 6.6+/-0.4 microg/mL, P<0.001 in men; 6.3+/-0.8 versus 7.6+/-0. 7 microg/mL in women). In contrast, plasma levels of leptin did not differ between diabetic patients with and without CAD. The presence of microangiopathy did not affect the plasma adiponectin levels in diabetic patients. Significant, univariate, inverse correlations were observed between adiponectin levels and fasting plasma insulin (r=-0.18, P<0.01) and glucose (r=-0.26, P<0.001) levels. In multivariate analysis, plasma insulin did not independently affect the plasma adiponectin levels. BMI, serum triglyceride concentration, and the presence of diabetes or CAD remained significantly related to plasma adiponectin concentrations. Weight reduction significantly elevated plasma adiponectin levels in the diabetic subjects as well as the nondiabetic subjects. These results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy. (+info)Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. (5/2639)
We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses. Adiponectin suppressed colony formation from colony-forming units (CFU)-granulocyte-macrophage, CFU-macrophage, and CFU-granulocyte, whereas it had no effect on that of burst-forming units-erythroid or mixed erythroid-myeloid CFU. In addition, adiponectin inhibited proliferation of 4 of 9 myeloid cell lines but did not suppress proliferation of erythroid or lymphoid cell lines except for one cell line. These results suggest that adiponectin predominantly inhibits proliferation of myelomonocytic lineage cells. At least one mechanism of the growth inhibition is induction of apoptosis because treatment of acute myelomonocytic leukemia lines with adiponectin induced the appearance of subdiploid peaks and oligonucleosomal DNA fragmentation. Aside from inhibiting growth of myelomonocytic progenitors, adiponectin suppressed mature macrophage functions. Treatment of cultured macrophages with adiponectin significantly inhibited their phagocytic activity and their lipopolysaccharide-induced production of tumor necrosis factor alpha. Suppression of phagocytosis by adiponectin is mediated by one of the complement C1q receptors, C1qRp, because this function was completely abrogated by the addition of an anti-C1qRp monoclonal antibody. These observations suggest that adiponectin is an important negative regulator in hematopoiesis and immune systems and raise the possibility that it may be involved in ending inflammatory responses through its inhibitory functions. (Blood. 2000;96:1723-1732) (+info)Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. (6/2639)
BACKGROUND: Among the many adipocyte-derived endocrine factors, we found an adipocyte-derived plasma protein, adiponectin, that was decreased in obesity. We recently demonstrated that adiponectin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced expression of endothelial adhesion molecules and that plasma adiponectin level was reduced in patients with coronary artery disease (CIRCULATION: 1999;100:2473-2476). However, the intracellular signal by which adiponectin suppressed adhesion molecule expression was not elucidated. The present study investigated the mechanism of modulation for endothelial function by adiponectin. METHODS AND RESULTS: The interaction between adiponectin and human aortic endothelial cells (HAECs) was estimated by cell ELISA using biotinylated adiponectin. HAECs were preincubated for 18 hours with 50 microg/mL of adiponectin, then exposed to TNF-alpha (10 U/mL) or vehicle for the times indicated. NF-kappaB-DNA binding activity was determined by electrophoretic mobility shift assays. TNF-alpha-inducible phosphorylation signals were detected by immunoblotting. Adiponectin specifically bound to HAECs in a saturable manner and inhibited TNF-alpha-induced mRNA expression of monocyte adhesion molecules without affecting the interaction between TNF-alpha and its receptors. Adiponectin suppressed TNF-alpha-induced IkappaB-alpha phosphorylation and subsequent NF-kappaB activation without affecting other TNF-alpha-mediated phosphorylation signals, including Jun N-terminal kinase, p38 kinase, and Akt kinase. This inhibitory effect of adiponectin is accompanied by cAMP accumulation and is blocked by either adenylate cyclase inhibitor or protein kinase A (PKA) inhibitor. CONCLUSIONS: These observations raise the possibility that adiponectin, which is naturally present in the blood stream, modulates the inflammatory response of endothelial cells through cross talk between cAMP-PKA and NF-kappaB signaling pathways. (+info)Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. (7/2639)
Adipocyte complement-related protein (30 kDa) (Acrp30), a secreted protein of unknown function, is exclusively expressed in differentiated adipocytes; its mRNA is decreased in obese humans and mice. Here we describe novel pharmacological properties of the protease-generated globular head domain of Acrp30 (gAcrp30). Acute treatment of mice with gAcrp30 significantly decreased the elevated levels of plasma free fatty acids caused either by administration of a high fat test meal or by i.v. injection of Intralipid. This effect of gAcrp30 was caused, at least in part, by an acute increase in fatty acid oxidation by muscle. As a result, daily administration of a very low dose of gAcrp30 to mice consuming a high-fat/sucrose diet caused profound and sustainable weight reduction without affecting food intake. Thus, gAcrp30 is a novel pharmacological compound that controls energy homeostasis and exerts its effect primarily at the peripheral level. (+info)Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. (8/2639)
BACKGROUND: Excessive lipid accumulation in macrophages plays an important role in the development of atherosclerosis. Recently, we discovered an adipocyte-specific plasma protein, adiponectin, that is decreased in patients with coronary artery disease. We previously demonstrated that adiponectin acts as a modulator for proinflammatory stimuli and inhibits monocyte adhesion to endothelial cells. The present study investigated the effects of adiponectin on lipid accumulation in human monocyte-derived macrophages. METHODS AND RESULTS: Human monocytes were differentiated into macrophages by incubation in human type AB serum for 7 days, and the effects of adiponectin were investigated at different time intervals. Treatment with physiological concentrations of adiponectin reduced intracellular cholesteryl ester content, as determined using the enzymatic, fluorometric method. The adiponectin-treated macrophages contained fewer lipid droplets stained by oil red O. Adiponectin suppressed the expression of the class A macrophage scavenger receptor (MSR) at both mRNA and protein levels by Northern and immunoblot analyses, respectively, without affecting the expression of CD36, which was quantified by flow cytometry. Adiponectin reduced the class A MSR promoter activity, as measured by luciferase reporter assay. Adiponectin treatment dose-dependently decreased class A MSR ligand binding and uptake activities. The mRNA level of lipoprotein lipase as a marker of macrophage differentiation was decreased by adiponectin treatment, but that of apolipoprotein E was not altered. Adiponectin was detected around macrophages in the human injured aorta by immunohistochemistry. CONCLUSIONS: The adipocyte-derived plasma protein adiponectin suppressed macrophage-to-foam cell transformation, suggesting that adiponectin may act as a modulator for macrophage-to-foam cell transformation. (+info)
Low Serum Adiponectin Levels Predict Future Risk For Asthma In Women - Redorbit
Total and high molecular weight adiponectin have similar utility for the identification of insulin resistance | Cardiovascular...
Association between asthma and serum adiponectin concentration in women | Thorax
Low adiponectin levels are an independent predictor of mixed and non-calcified coronary atherosclerotic plaques.
Longitudinal changes in the relationship between serum adiponectin concentration and cardiovascular risk factors among...
Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced...
Association between lifestyle factors and plasma adiponectin levels in Japanese men | Lipids in Health and Disease | Full Text
The Significance of Elevated Adiponectin in the Treatment of Type 2 Diabetes<...
C/EBPα Regulates Human Adiponectin Gene Transcription Through an Intronic Enhancer | Diabetes
HMW ADNP elisa kit | Canine High Molecular Weight Adiponectin ELISA Kit
Vagal Hyperactivity Due to Ventromedial Hypothalamic Lesions Increases Adiponectin Production and Release | Diabetes
Leptin/adiponectin Ratio in Overweight Patients - Gender Differences | Repository UHC Osijek
The Adipokine Adiponectin Can Be Elevated in Graves Ophthalmopathy | IOVS | ARVO Journals
A Novel Role for Adiponectin in the Regulation of Inflammation | Arteriosclerosis, Thrombosis, and Vascular Biology
Treatment-Induced Changes in Plasma Adiponectin Do Not Reduce Urinary by Kieren J. Mather, Qing Pan et al.
Abstract 817: Glucose Loading Increases Adiponectin Levels in Subjects With Impaired Glucose Tolerance and Impairs Endothelial...
eNOS plays a major role in adiponectin synthesis in adipocytes
Plus it
Product XKine Adiponectin • HumanZyme
The Effect of Zinc Supplementation on Serum Adiponectin Concentration and Insulin Resistance in First Degree Relatives of...
Ethnic Differences in the Relationship Between Adiponectin and Insulin Sensitivity in South Asian and Caucasian Women |...
The Multi-Level Action of Fatty Acids on Adiponectin Production by Fat Cells
The clinical implications of blood adiponectin in cardiometabolic disorders. - Semantic Scholar
Abstract 16583: Variations of Circulating Levels of Adiponectin Impact Two-Years Cardiovascular Outcomes in Patients With Acute...
Inverse association between serum adiponectin level and transaminase activities in Japanese male workers<...
Association of low serum adiponectin levels with erosive esophagitis in men: An analysis of 2405 subjects undergoing physical...
PPARγ-Activating Angiotensin Type-1 Receptor Blockers Induce Adiponectin | Hypertension
Serum Adiponectin in Chinese Population and Its Correlation to Cardiovascular and Cerebrovascular Diseases - Full Text View -...
Veterinary Sciences | Free Full-Text | Myocardial Adiponectin Isoform Shift in Dogs with Congestive Heart Failure-A Comparison...
Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma
Systemic fate of the adipocyte-derived factor adiponectin<...
Association of ADIPOQ gene with obesity and adiponectin levels in Malaysian Malays
HKU Scholars Hub: Chronic adiponectin deficiency leads to Alzheimers disease-like cognitive impairments and pathologies...
Validating impact of temporal changes of adiponectin in relation to ROP development | IOVS | ARVO Journals
Recombinant human Adiponectin protein (trimeric) (ab28159) References
Recombinant human Adiponectin protein (trimeric) (ab28159) Protocols
Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines. - Nuffield...
Plus it
Gene Variation Linked To Colon Cancer | EmaxHealth
Calcium is involved in formation of high molecular weight adiponectin - Fingerprint
- [email protected]
Adiponectin - Wikipedia
UCP1-3826 AG+GG genotypes, adiponectin, and leptin/adiponectin ratio in severe obesity
ActoFactor™ Recombinant Human Adiponectin (Adipocyte Complement Related Protein of 30 kDa; E. coli) | Creative Bioarray
FRI0010 Effects of leptin and adiponectin on proliferation, activation and th17 differentiation were significantly increased in...
PRIME PubMed | Association of low adiponectin levels with the metabolic syndrome--the Chennai Urban Rural Epidemiology Study ...
Effect of Exercise Training on Adiponectin Receptor Expression and Insulin Resistance in Mice Fed a High Fat Diet | Science...
Serum Adiponectin Levels in Patients with Familial Mediterranean Fever | Bentham Science
Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter...
Inhibition of islet immunoreactivity by adiponectin is attenuated in human type 1 diabetes. - Radcliffe Department of Medicine
A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels
Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer : a Mendelian Randomization...
Design and development of a peptide-based adiponectin receptor agonist for cancer treatment | BMC Biotechnology | Full Text
Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease<...
The association of SNP276G|T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight...
Role of adiponectin in adipose tissue wound healing | GMR | Genetics and Molecular Research | The Original by FUNPEC-RP
Serum Adiponectin levels in Different Phenotypes of Polycystic Ovary Syndrome
Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory...
The effects of adiponectin gene polymorphisms on the progression of carotid intima-media thickness
Expression of adiponectin in the subchondral bone of lumbar facet joints with different degrees of degeneration | BMC...
Adiponectin and leptin in overweight/obese and lean women with polycystic ovary syndrome<...
Dynamic alteration of adiponectin/adiponectin receptor expression and by Yanzhuo Ma, Yi Liu et al.
Recombinant Adiponectin Receptor 1 (ADIPOR1), Cat#RPU40113 - Biomatik
Adiponectin levels, insulin resistance and their relationship with serum levels of inflammatory cytokines in patients with...
Adiponectin and adiponectin receptor 1 overexpression enhance inflammatory bowel disease | Journal of Biomedical Science | Full...
Effect of Selenium on Serum Adiponectin, Homocystein and Malnutrition-inflammation Complex Syndrome in Hemodialysis Patients -...
TCDB » SEARCH
Hormone may protect against development of insulin resistance during weight gain | News | Research | Memorial University of...
TCDB » SEARCH
Serum from pregnant women with gestational diabetes mellitus increases the expression of FABP4 mRNA in primary subcutaneous...
Diabetology of Pregnancy (Frontiers in Diabetes) by J. Djelmiš, G. Desoye, M. Ivaniševic, M. Porta, F.M. - TravelMate...
Reya Lab | Identification of Adiponectin As a Novel Hematopoietic Stem Cell Growth Factor
Single nucleotide polymorphism rs3774261 in the AdipoQ gene is associated with the risk of coronary heart disease (CHD) in...
Adiponectin Receptor Detection: Antibodies
Adiponectin Receptor Detection: Antibodies
Green Tea Extract and Catechol-O-Methyltransferase Genotype Modify Fasting Serum Insulin and Plasma Adiponectin Concentrations...
Adiponectin and negative mood in healthy premenopausal and postmenopausal women<...
The Multi-Level Action of Fatty Acids on Adiponectin Production by Fat Cells
High-molecular-weight adiponectin and anthropometric variables among elementary schoolchildren: a population-based cross...
Hope for Those with Diabetic Periodontal Disease
Plus it
Adiponectin receptor signaling on dendritic cells blunts antitumor immunity. - Nuffield Department of Surgical Sciences
Adiponectin Receptor Type 1 (Adipo R1) (357-375) (Human) - Biotin Labeled Purified IgG
Adiponectin/resistin levels and insulin resistance in children: a four country comparison study | International Journal of...
The combined effect of adiponectin and resistin on all-cause mortality in patients with type 2 diabetes: Evidence of synergism...
Rat ADIPOR1(Adiponectin Receptor 1) ELISA Kit - Signet Laboratories
Daily Dose Of Fish Oil May Reduce Risk Of Diabetes, Heart Disease - Redorbit
Women Health: Rosiglitazone treatment increases plasma levels of adiponectin and decreases levels of resistin in overweight...
List of OMIM disorder codes
ADSL Adiponectin deficiency; 612556; ADIPOQ Adrenal cortical carcinoma; 202300; TP53 Adrenal hyperplasia, congenital, due to 11 ...
Postmenopausal confusion
Research focusing on adiponectin (ADPN) has yielded positive results in the development of possible treatments for ... Rizzo, Maria Rosaria; Fasano, Renata; Paolisso, Giuseppe (2020). "Adiponectin and Cognitive Decline". International Journal of ...
AdipoRon
... small-molecule agonist of the adiponectin receptors to be identified. Adiponectin receptor agonists such as AdipoRon have ... Dysregulation of adiponectin expression has also been implicated in the pathology of mood disorders, anxiety disorders, eating ... As such, adiponectin receptor agonists are a highly interesting therapeutic target for a variety of different conditions. ... In addition, adiponectin has recently been elucidated to mediate the antidepressant, anxiolytic, and neurogenic effects of ...
Biomarkers of diabetes
Regulating cytokines like leptin and adiponectin. OXT decreased fat mass, resulting in reduction in leptin level. Oxytocin may ... and late-onset obesity with increases in abdominal fats and fasting plasma triglycerides The balance of leptin and adiponectin ... cross-sectional evaluation of baseline circulating levels of the novel hormone Irisin and the established adipokine adiponectin ...
RAB11FIP1
... has been identified as a novel protein involved in the regulation of adiponectin trafficking and release from the ... RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte ... potentially contributing to lower circulating levels of adiponectin observed in obese populations. RAB11FIP1 has been shown to ... "The Rab11 Effector Protein FIP1 Regulates Adiponectin". PLOS ONE. 8 (9): e74687. doi:10.1371/journal.pone.0074687. PMC 3770573 ...
TFAP2B
A negative regulator of adiponectin gene expression". J. Biol. Chem. 281 (42): 31245-53. doi:10.1074/jbc.M605132200. PMID ...
SOGA2
October 2010). "Adiponectin lowers glucose production by increasing SOGA". Am. J. Pathol. 177 (4): 1936-45. doi:10.2353/ajpath. ...
Brown adipose tissue
... and they have higher circulating adiponectin, suggesting a link between longevity and adiponectin production. In addition, high ... Brown adipose tissue activation through cold exposure increases adiponectin levels, just two hours of cold exposure resulted in ... Centenarians (both men and women) and their offspring have been found to have genetics that boost adiponectin, ... Imbeault, Pascal; Dépault, Isabelle; Haman, François (2009-04-01). "Cold exposure increases adiponectin levels in men". ...
Silent stroke
Adiponectin: is a type of protein secreted by adipose cells that improves insulin sensitivity and possesses antiatherogenic ... Lower levels of s-adiponectin are associated with ischemic stroke. Aging: the prevalence of silent stroke rises with increasing ... Bang, OY; Saver, JL; Ovbiagele, B; Choi, YJ; Yoon, SR; Lee, KH (2007). "Adiponectin levels in patients with intracranial ...
Resistin
Stumvoll M, Häring H (November 2002). "Resistin and adiponectin--of mice and men". Obes. Res. 10 (11): 1197-9. doi:10.1038/oby. ... Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ (October 2003). "Plasma resistin, adiponectin and leptin levels ... Milan G, Granzotto M, Scarda A, Calcagno A, Pagano C, Federspil G, Vettor R (November 2002). "Resistin and adiponectin ... Wulster-Radcliffe MC, Ajuwon KM, Wang J, Christian JA, Spurlock ME (April 2004). "Adiponectin differentially regulates ...
FGF21
... can inhibit mTORC1 in the liver and stimulate adiponectin secretion from fatty tissues, thereby inhibiting aging- ... FGF21 induces the insulin-sensitizing hormone adiponectin. FGF21 treatment of adipocytes is associated with phosphorylation of ... improved serum lipid profile and adiponectin levels, with no effect on HbA1c. xSubcutaneous treatment of obese, diabetic ... reduce overweight and improve plasma lipid profile while increasing circulating adiponectin. Serum FGF21 levels are ...
Parthenolide
Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor ... Agonist of the adiponectin receptor 2 (AdipoR2). Inhibition of mammalian thioredoxin reductase Onozato, Thelma; Nakamura, Celso ... Adiponectin receptor agonists, Epoxides, Histone deacetylase inhibitors, Sesquiterpene lactones). ...
Caloric restriction mimetic
Adiponectin (together with leptin, it regulates adipose tissue metabolism. It is activated by PPAR inhibitors such as ... It also blocks the beneficial actions of adiponectin. Rimonabant inhibits these and so it reduces appetite, balances energy, ... and increases adiponectin, which reduces intra-abdominal fat. It improves lipid profile, glucose tolerance, and waist ...
Non-alcoholic fatty liver disease
Adiponectin has several properties that protect the liver. These properties include improved liver fat metabolism, decreased de ... Adipose tissue dysfunction also decreases secretion of the insulin-sensitizing adipokine adiponectin in people with NAFLD. ...
Maternal effect
Adiponectin has also been shown to increase the rate of fatty acid transport and oxidation in mice, which causes an increase in ... The adiponectin genes regulate glucose metabolism as well as fatty acid breakdown; however, the exact mechanisms are not ... Therefore, there was less adiponectin to help cells take up glucose and break down fat, as well as less leptin to cause a ... With a high fat diet during gestation, there was an increase in methylation in the promoter of the adiponectin gene accompanied ...
Fast protein liquid chromatography
"Isolation and quantitation of adiponectin higher order complexes". Methods in Enzymology. Methods of Adipose Tissue Biology, ...
Research into centenarians
It is believed that centenarians possess a different adiponectin isoform pattern and have a favorable metabolic phenotype in ... "Assessment of adiponectin and its isoforms in Polish centenarians". Experimental Gerontology. 48 (4): 401-407. doi:10.1016/j. ...
Macrophage polarization
February 2010). "Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype". The Journal of Biological ...
Japanese scientific misconduct allegations
The Nature paper, which allegedly identified the adiponectin receptors AdipoR1 and AdipoR2 by expression cloning using FACS, ... "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762-769. Bibcode:2003Natur. ... Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 431 (7012): 1123. doi:10.1038/ ...
G protein-coupled receptor
June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762-9. Bibcode: ... such as microbial rhodopsins and adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2). However, these 7TMH (7-transmembrane ...
Breast cancer
Jardé T, Perrier S, Vasson MP, Caldefie-Chézet F (January 2011). "Molecular mechanisms of leptin and adiponectin in breast ...
ABCA1
Adiponectin induces reverse cholesterol transport by an ABCA1-dependent pathway. Other endogenous metabolites more loosely ... Hafiane A, Gasbarrino K, Daskalopoulou SS (November 2019). "The role of adiponectin in cholesterol efflux and HDL biogenesis ...
Sp7 transcription factor
Adiponectin is a protein hormone that has been shown to be upregulated in rheumatoid arthritis disease pathology, causing the ... In primary human cell cultures Sp7 was shown to be inhibited by adiponectin thus contributing downregulation of the creation of ... May 2017). "Response of human rheumatoid arthritis osteoblasts and osteoclasts to adiponectin". Clinical and Experimental ...
Jillian Cornish
"In vitro and in vivo effects of adiponectin on bone." Endocrinology 150, no. 8 (2009): 3603-3610. Naot, Dorit, Andrew Grey, Ian ...
Orexin
It also inhibits lipolysis and stimulates the secretion of adiponectin. These effects are thought to be mostly conferred via ... July 2011). "Orexin A stimulates glucose uptake, lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and ...
Bone marrow adipose tissue
WAT is also the source of adipokines and inflammatory markers which have both positive (e.g., adiponectin) and negative effects ... Ye R, Scherer PE (April 2013). "Adiponectin, driver or passenger on the road to insulin sensitivity?". Molecular Metabolism. 2 ... Recently, BMAT was noted to "produce a greater proportion of adiponectin - an adipokine associated with improved metabolism - ... August 2014). "Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during ...
ATF3
"Essential role of mitochondrial function in adiponectin synthesis in adipocytes". Diabetes. 56 (12): 2973-81. doi:10.2337/db07- ...
Abdominal obesity
But adiponectin, an anti-inflammatory adipokine, which is found in lower concentration in obese and diabetic individuals has ... August 2015). "Adiponectin as a Protective Factor Against the Progression Toward Type 2 Diabetes Mellitus in Postmenopausal ... Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ (October 2003). "Plasma resistin, adiponectin and leptin levels ... June 2004). "Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity". Obesity Research ...
Maitree Bhattacharyya
Ghoshal, K; Bhattacharyya, M (2015). "Adiponectin: Probe of the molecular paradigm associating diabetes and obesity". World J ... Ghoshal, K., & Bhattacharyya, M. (2015). Adiponectin: Probe of the molecular paradigm associating diabetes and obesity. World ...
Peptides (journal)
... and adiponectin". Peptides. 27 (4): 911-6. doi:10.1016/j.peptides.2005.12.014. PMID 16476508. Steckelings, U; Kaschina, E; ...
Adiponectin receptors | The Scientist Magazine®
Adiponectin is a circulating protein, the serum level of which is decreased in obesity and diabetes and in patients with ... Adiponectin receptors. Novel proteins controlling metabolism could lead to a new treatment for diabetes. Cathy Holding(cholding ... Toshimasa Yamauchi and colleagues at the University of Tokyo report the cloning of two separate adiponectin receptors, one from ... The protein enhances insulin sensitivity by improving glucose and lipid metabolism, suggesting that adiponectin may have a role ...
Niacin stimulates adiponectin secretion through the GPR109A receptor
... has recently been shown to increase serum adiponectin concentrations in men with the metabolic syndrome. However, little is ... known about the mechanism(s) by which niacin regulates the intracellular trafficking and secretion of adiponectin. Since niacin ... Niacin stimulates adiponectin secretion through the GPR109A receptor Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E549-58. ... and serum was obtained for the determination of adiponectin and NEFA concentrations. Serum adiponectin concentrations increased ...
Recombinant Mouse Adiponectin protein (ab285685) | Abcam
Recombinant Mouse Adiponectin protein is an Escherichia coli Full length protein, , 90% purity, , 1.000 Eu/µg endotoxin level ... Defects in ADIPOQ are the cause of adiponectin deficiency (ADPND) [MIM:612556]. ADPND results in very low concentrations of ... Hydroxylation and glycosylation of the lysine residues within the collagene-like domain of adiponectin seem to be critically ... This product is manufactured by BioVision, an Abcam company and was previously called 4902 Adiponectin, murine recombinant. ...
Browsing by Subject "Adiponectin"
Adiponectin has profound insulin-sensitizing, anti-inflammatory and anti-atherogenic effects. However, reports of the role of ... Associations between single-nucleotide polymorphisms of ADIPOQ, serum adiponectin and increased type 2 diabetes mellitus risk ... genotypes and investigate the association between the two SNPs and adiponectin concentration, metabolic parameters and risk of ... adiponectin in pre-eclampsia are conflicting. This study in Egypt investigated the association ... ...
adiponectin
Evaluation of multiplex immunoassays, used for determination of adiponectin, resistin, leptin, and ghrelin from human blood...
Adiponectin Testing Market - Talk to Analyst | Future Market Insights
Adiponectin in Youth | Diabetes Care | American Diabetes Association
1) in this issue of Diabetes Care regarding adiponectin in youth. We are excited to have received the opinion of in ... 0.02 with adiponectin and insulin sensitivity in the formula; R2 = 0.162, P = 0.007 with only adiponectin in the formula). Also ... Adiponectin in Youth: Response to Stefan et al. Fida Bacha, MD; Fida Bacha, MD ... Fida Bacha, Rola Saad, Neslihan Gungor, Silva A. Arslanian; Adiponectin in Youth: Response to Stefan et al.. Diabetes Care 1 ...
Adiponectin Human HEK293 | BioVendor R&D
Recombinant human Adiponectin is expressed in HEK293.Tested applications are: Cell culture and/or animal studies, ELISA, ... Adiponectin. By Technical Data. Adiponectin - Proteins. Adiponectin - Recombinant protein - Proteins. Human - Adiponectin - ... Adiponectin - for Western blotting - Proteins. Adiponectin - for ELISA - Proteins. Adiponectin - for Cell culture and/or animal ... References to Adiponectin. *Lam KS, Xu A. Adiponectin: protection of the endothelium. Curr Diab Rep. 2005, 5, 254-259. ...
Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology<...
Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. In: American Journal of Human Genetics. 2019 ... Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. American Journal of Human Genetics. 2019;105 ... Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. Cassandra N. Spracklen, Tugce Karaderi, ... Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. / Spracklen, Cassandra N.; Karaderi, Tugce; ...
WHO EMRO | Adiponectin levels in serum of women with pre-eclampsia | Volume 17, issue 7 | EMHJ volume 17, 2011
This study in Egypt investigated the association between serum adiponectin levels and pre-eclampsia and between adiponectin ... Serum adiponectin levels in pre-eclamptic women were significantly higher than in normal pregnant women and the increase was ... The results support the theory that adiponectin might be part of a feedback mechanism improving insulin sensitivity and ... There was a significant negative correlation between adiponectin levels and arterial blood pressure in all groups. However, ...
Effects of habitual t'ai chi exercise on adiponectin, glucose homeostasis, lipid profile, and atherosclerotic burden in...
... ai chi exercise on adiponectin, glucose homeostasis, lipid profile, and atherosclerotic burden in individuals with ... Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and ... Adiponectin and atherosclerosis risk factors in African hemodialysis patients: a population at low risk for atherosclerotic ... Beneficial Effects of Adiponectin on Glucose and Lipid Metabolism and Atherosclerotic Progression: Mechanisms and Perspectives ...
Exploration of inflammation, oxidative stress, adiponectin and intestinal flora in patients with hepatitis B, liver cirrhosis...
... adiponectin and intestinal flora in patients with hepatitis B, liver cirrhosis and hepatocellular carcinoma - Minerva ... Xu J, Liu K, Ma Z, Lin Y, Pang L. Exploration of inflammation, oxidative stress, adiponectin and intestinal flora in patients ... Exploration of inflammation, oxidative stress, adiponectin and intestinal flora in patients with hepatitis B, liver cirrhosis ...
Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in nonobese...
Chan, D., Watts, G., Ooi, E., Chan, D. T., Wong, A. T. Y., & Barrett, H. (2011). Apolipoprotein A-II and adiponectin as ... Chan, D, Watts, G, Ooi, E, Chan, DT, Wong, ATY & Barrett, H 2011, Apolipoprotein A-II and adiponectin as determinants of very ... T1 - Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in ... Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in nonobese ...
Relations of plasma total and high-molecular-weight adiponectin to new-onset heart failure in adults ≥65 years of age (from the...
Results were similar for HMW adiponectin. In conclusion, total and HMW adiponectin showed comparable relations with incident HF ... Results were similar for HMW adiponectin. In conclusion, total and HMW adiponectin showed comparable relations with incident HF ... Results were similar for HMW adiponectin. In conclusion, total and HMW adiponectin showed comparable relations with incident HF ... Results were similar for HMW adiponectin. In conclusion, total and HMW adiponectin showed comparable relations with incident HF ...
Exercise training is not associated with improved levels of C-reactive protein or adiponectin<...
Exercise training is not associated with improved levels of C-reactive protein or adiponectin. In: Metabolism: Clinical and ... Exercise training is not associated with improved levels of C-reactive protein or adiponectin. / Marcell, Taylor J.; McAuley, ... Dive into the research topics of Exercise training is not associated with improved levels of C-reactive protein or adiponectin ... Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism: Clinical and ...
Can't lose weight? Maybe it's your Adiponectin Levels? - Susan B. Dopart
My what? What exactly is Adiponectin?. Adiponectin is a protein that is related to how well you metabolize fat and even your ... The accumulation of abdominal fat can be associated with a decline in adiponectin. Adiponectin is produced by the bodys fat ... Cant lose weight? Maybe its your Adiponectin Levels?. Susan Dopart Exercise, Get Moving!, Great Idea!, Health and Lifestyle, ... One study showed adiponectin levels rose 260% after 2-3 bouts of exercise and stayed elevated for a few weeks. Another study ...
Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents - WRAP: Warwick Research Archive...
2006) Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. Atherosclerosis, Volume 189 ( ... Circulating levels of adiponectin (AD), plasminogen activator inhibitor I (PAI-1), interleukin 18 (IL-18), C-reactive protein ( ... Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents ...
Serum leptin, resistin, visfatin and adiponectin levels in tumour necrosis factor receptor-associated periodic syndrome (TRAPS)...
Objectives: The aims of our study were to evaluate serum leptin, resistin, visfatin and adiponectin levels in patients with ... N2 - Objectives: The aims of our study were to evaluate serum leptin, resistin, visfatin and adiponectin levels in patients ... AB - Objectives: The aims of our study were to evaluate serum leptin, resistin, visfatin and adiponectin levels in patients ... Dive into the research topics of Serum leptin, resistin, visfatin and adiponectin levels in tumour necrosis factor receptor- ...
An adiponectin-S1P axis protects against lipid induced insulin resistance and cardiomyocyte cell death via reduction of...
Our data establish adiponectin signaling-mediated increase in S1P secretion as a mechanism via which HFD or PA induced ... 6-week-old male adiponectin knock out (Ad-KO) mice were fed chow or 60% HFD for 6 weeks then received saline or recombinant ... This study investigated the mechanisms of adiponectin action in the heart during high fat diet (HFD) feeding or in palmitate ( ... H9c2 cardiomyocytes were treated ±0.1 mM PA, the adiponectin receptor agonist AdipoRon, or the antioxidant MnTBAP then assays ...
Adiponectin as predictor for diabetes among pre-diabetic groups - Fingerprint
- Yonsei University
Leptin, Adiponectin, and Heart Rate Variability Among Police Officers
Adiponectin Adiposity Adult Aged Body Mass Index Cross-Sectional Studies Female Heart Rate Humans Leptin Male Middle Aged ... Leptin, but not adiponectin, was significantly and inversely associated with HRV. Body mass index (BMI) and percent body fat ... Leptin and adiponectin may be related to CVD health. Therefore, our objective was to investigate the relationship between these ... Leptin and adiponectin levels were measured in 388 officers from the Buffalo Cardio-Metabolic Occupational Police Stress study ...
Pathogenesis of bone disease in multiple myeloma: from bench to bedside | Blood Cancer Journal
Adiponectin. Adiponectin constitutes an adipocyte-derived hormone that is also expressed by osteoblasts and BMSCs. Both ... Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J. Cell. Biochem. 99, 196-208 ( ... Host-derived adiponectin is tumor-suppressive and a novel therapeutic target for multiple myeloma and the associated bone ... The direct pathway by circulating adiponectin is inhibitory, while all the others are stimulatory99. In a murine MM model, ...
adiponectin - Jobber Wiki
Saffron supplementation with aerobic exercise may improve blood sugar, inflammation and metabolism in obese diabetics We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok Source link ...
Raspberry Ketone | Adiponectin
... scientific and commercial benefits of the natural burner and Adiponectin ... Raspberry Ketone - the natural fat burner that lowers Adiponectin levels. Natalie Jay Weight Loss Articles ... In adults, levels of Adiponectin are inversely correlated with body fat percentage. This means people with more in their system ... Researchers theorize Raspberry Ketone causes the body to secret more Adiponectin, a protein hormone involved in metabolizing ( ...
Adiponectin - Pharmawiki.in
Adiponectin Archives - Diapharma
Adipose Tissue | Diabetes | American Diabetes Association
The adiponectin sensitivity index (SA) reflects the fraction of adiponectin found in the HMW form. This index has become ... Adiponectin-mediated weight gain can be augmented even further. If a more active version of adiponectin (a protein carrying a ... The curves for adiponectin and leptin double-null mice (Ad-/-Ob-/-, gray), obese adiponectin wild type-mice (Ad+/+Ob-/-, dashed ... The curves for adiponectin and leptin double-null mice (Ad-/-Ob-/-, gray), obese adiponectin wild type-mice (Ad+/+Ob-/-, dashed ...
Adiponectin through its biphasic serum level is a useful biomarker during transition from diastolic dysfunction to systolic...
Thereafter, adiponectin levels increased prior to occurrence of systolic dysfunction. Adiponectin concentration is inversely ... No difference for adiponectin distribution among visceral adipose tissues was found. Adiponectin through its biphasic serum ... Meanwhile, tissue and serum adiponectin decreased from 3 months and reached plateau until 12 months in parallel with decreasing ... as well as serum level and tissue expression of adiponectin were determined at the same time as echocardiography. The results ...
Adiponectin is associated with insulin sensitivity in white European men but not black African men<...
Adiponectin is associated with insulin sensitivity in white European men but not black African men. / Hakim, Olah; Bello, ... Adiponectin is associated with insulin sensitivity in white European men but not black African men. In: Diabetic Medicine. 2021 ... Adiponectin is associated with insulin sensitivity in white European men but not black African men. Diabetic Medicine. 2021 Mar ... title = "Adiponectin is associated with insulin sensitivity in white European men but not black African men", ...
LeptinReceptorsPlasma adiponectinADIPOQInsulin sensitivityAdipokinesMouse AdiponectinProteinRole of adiponectinExpression of adiponectinLevelsConcentrationsRecombinantCoronary arteryHormoneMetabolicAdiposeAdipocytesSecretion of adiponectinObesityCirculatingGlobular domainTotal adiponectinIncrease adiponectinELISA KitProteinsRegulatesAdipoR2DiabetesCorrelationReceptor 1 geneBiologically activeCollagen domainSystolic dysfunctionNegatively associatedGeneHomeostasisHigh-molecular weightCardiovascular diseasesFattyAnti-atherogenicMetabolismPlateletSecretory
Leptin10
- Objectives: The aims of our study were to evaluate serum leptin, resistin, visfatin and adiponectin levels in patients with tumour necrosis factor receptorassociated periodic syndrome (TRAPS), in comparison to healthy controls, and to correlate their levels to parameters of disease activity and/or severity. (elsevier.com)
- Methods: Serum leptin, resistin, visfatin and adiponectin levels were obtained from 14 TRAPS patients carrying mutations involving cysteine residues, from 16 TRAPS patients carrying other mutations, and from 16 healthy controls. (elsevier.com)
- Results: Serum leptin, resistin, visfatin and adiponectin did not significantly differ among the 3 groups. (elsevier.com)
- There is an increasing recognition that adipose tissue is an endocrine organ secreting a number of biologically active adipokines such as leptin, adiponectin, and tumor necrosis factor-α. (docksci.com)
- Furthermore, some of these molecules, such as leptin, PAI-1, and adiponectin, are known to contribute to the development of hypertension [ 9 , 13 , 14 ] ( Figure 1 ). (hindawi.com)
- Adipokines ( adiponectin and leptin ), full serum lipid , and inflammatory factors [ white blood cell counts, C-reactive protein , tumor necrosis factor -α, tissue plasminogen activator inhibitor-1 ( PAI-1 )] were measured in 101 sedentary and 100 endurance-trained healthy Japanese women ( aged 18-23 years). (bvsalud.org)
- Serum adipokines including high molecular weight (HMW)-adiponectin, leptin, and soluble leptin receptor (sOB-R) were measured at the follow-up visit (2002-2003). (cdc.gov)
- Conclusions: Our findings suggest that molybdenum was associated with favorable profiles of HMW-adiponectin, leptin, and sOB-R. Exposures to cadmium, cesium, and lead were associated with adverse adipokine profiles. (cdc.gov)
- Adiponectin, leptin and resistin are adipocyte-secreted peptide hormones that may influence RCC development through their demonstrated effects on inflammation, insulin resistance and cell growth and proliferation. (arctichealth.org)
- We conducted a nested case-control study to evaluate whether prediagnostic serum adiponectin, leptin and resistin levels are associated with RCC risk. (arctichealth.org)
Receptors4
- Activation of adiponectin receptors (AdipoRs) by its natural ligand, adiponectin has been known to be involved in modulating critical metabolic processes such as glucose metabolism and fatty acid oxidation as demonstrated by a number of in vitro and in vivo studies over last two decades. (phoenixpeptide.com)
- Adiponectin is abundant in plasma and accounts for 0.01% of total plasma proteins in humans and 0.05% in rodents [9,12] .Two adiponectin receptors have been identified. (ommegaonline.org)
- Receptors for adiponectin, estradiol and antidiuretic hormone were more highly expressed in the summer months. (promegaconnections.com)
- A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome. (cdc.gov)
Plasma adiponectin1
- Maternal plasma adiponectin showed inverse relations with glucose and homeostatic model assessment of insulin resistance (both P (biomedcentral.com)
ADIPOQ1
- Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 aminoacid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells. (biovendor.com)
Insulin sensitivity17
- The protein enhances insulin sensitivity by improving glucose and lipid metabolism, suggesting that adiponectin may have a role in preventing atherosclerosis, in addition to its beneficial impact on glucose and lipid homeostasis, and that improving levels of adiponectin could represent a novel therapeutic approach to the treatment of diabetes. (the-scientist.com)
- we investigated the relationship between the proinsulin-to-insulin ratio and adiponectin after adjusting for insulin sensitivity per metabolically active fat-free mass. (diabetesjournals.org)
- The partial correlation coefficient of adiponectin to the proinsulin-to-insulin ratio after controlling for insulin sensitivity was r = −0.24, two-tailed P = 0.12, and one-tailed P = 0.06. (diabetesjournals.org)
- Also, in an effort to determine if adiponectin is related to an index of glucose homeostasis, we evaluated the correlation of adiponectin with the glucose disposition index (product of insulin sensitivity × first-phase insulin secretion), which revealed that r = 0.35 and P = 0.013. (diabetesjournals.org)
- Adiponectin concentrations correlate negatively with glucose, insulin, triglyceride concentrations, liver fat content and body mass index and positively with high-density lipoprotein-cholesterol levels, hepatic insulin sensitivity and insulin-stimulated glucose disposal. (biovendor.com)
- Adiponectin has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation. (biovendor.com)
- The results support the theory that adiponectin might be part of a feedback mechanism improving insulin sensitivity and cardiovascular health in pre-eclamptic patients. (who.int)
- Subjects had their insulin sensitivity, body fat, CRP, and adiponectin levels measured, and their predicted maximal fitness calculated before and after 16 weeks of moderate, intense, or no exercise training. (elsevier.com)
- Modest improvements in fitness, body composition, and insulin sensitivity were observed, but these changes were not associated with decreased CRP or increased adiponectin levels, even when subjects were stratified by their change in fitness or obesity. (elsevier.com)
- Regression analysis demonstrated that the change in percentage of body fat was significantly related to changes in insulin sensitivity, whereas changes in VO 2 MAX, CRP, and adiponectin were not. (elsevier.com)
- Weight loss or caloric restriction results in increasing adiponectin levels, and this increase is related to enhanced insulin sensitivity. (cusabio.com)
- One of the most prevalent serum adipokines, adiponectin, is well-known for its function in regulating insulin sensitivity and preventing metabolic syndrome from developing. (iscience.in)
- Relationships of adiponectin to regional adiposity, insulin sensitivity, serum lipids, and inflammatory markers in sedentary and endurance-trained Japanese young women. (bvsalud.org)
- However, no significant correlation between adiponectin and insulin sensitivity was detected in both groups. (bvsalud.org)
- These findings suggest that adiponectin is primarily associated with regional adiposity and HDL-C regardless of insulin sensitivity and physical activity status in young, healthy women . (bvsalud.org)
- Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. (medecinesciences.org)
- Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study. (cdc.gov)
Adipokines1
- Among various adipocyte-derived adipokines, adiponectin has attracted considerable attention due to its role in cardiovascular disorders. (docksci.com)
Mouse Adiponectin2
- CUSABIO's mouse adiponectin (ADP) ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative determination of adiponectin concentrations in serum, plasma, cell culture supernates, tissue homogenates, and cell lysates. (cusabio.com)
- This assay exclusively recognizes mouse adiponectin. (cusabio.com)
Protein14
- Adiponectin is a circulating protein, the serum level of which is decreased in obesity and diabetes and in patients with coronary heart disease, and increased during weight loss. (the-scientist.com)
- Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular and metabolic risk, are highly heritable. (dtu.dk)
- The purpose of this study was to determine the effect of exercise training on the levels of C-reactive protein (CRP) and adiponectin, and to assess whether exercise-induced changes in insulin resistance could be explained in part by changes in these inflammation markers. (elsevier.com)
- Adiponectin is a protein that is related to how well you metabolize fat and even your risk of developing certain cancers. (susandopart.com)
- Circulating levels of adiponectin (AD), plasminogen activator inhibitor I (PAI-1), interleukin 18 (IL-18), C-reactive protein (CRP), fibrinogen, uric acid, lipids and insulin were measured. (warwick.ac.uk)
- Researchers theorize Raspberry Ketone causes the body to secret more Adiponectin, a protein hormone involved in metabolizing (breaking down) fatty acids and regulating glucose levels. (slimmersweekly.com)
- Around the same time, we and others described a protein that we initially termed Acrp30, which later became known as adiponectin ( 7 - 10 ). (diabetesjournals.org)
- Adiponectin is an adipocyte-specific protein abundantly present in the plasma. (ommegaonline.org)
- Finally, we discuss the potential involvement of endoplasmic reticulum stress and mitochondrial stress in diet-induced adiponectin downregulation and highlight the roles of Disulfide bond A oxidoreductase-like protein (DsbA-L) in the prevention of endoplasmic reticulum stress and promotion of adiponectin multimerization, stability, and function. (unm.edu)
- Adiponectin (APN), an adipocytokine, is secreted by the adipose tissue and has been debated both as a pro-inflammatory or anti-inflammatory protein depending on the disease condition and microenvironment. (mycologics.net)
- 2007). Exercise training is associated with improved levels of C-reactive protein and adiponectin in ZDF (type 2) diabetic rats . (up.pt)
- Novel modulator for endothelial adhesion molecules : adipocyte-derived plasma protein adiponectin. (medecinesciences.org)
- PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. (medecinesciences.org)
- Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis. (bvsalud.org)
Role of adiponectin2
- However, reports of the role of adiponectin in pre-eclampsia are conflicting. (who.int)
- However, the role of adiponectin in the development of cardiac diseases remains less clear than it does for metabolic disorders. (biomedcentral.com)
Expression of adiponectin2
- Moreover, serum levels of N-terminal pro-natriuretic peptide (NT-proBNP) and interleukin-6 (IL-6) as well as serum level and tissue expression of adiponectin were determined at the same time as echocardiography. (biomedcentral.com)
- Objective To investigate the effects of hypoxia induced by CoCl 2 on the expression of adiponectin (ADPN) in mouse 3T3-L1 adipocytes. (shsmu.edu.cn)
Levels58
- Paradoxically, adipose tissue-expressed adiponectin levels are inversely related to the degree of adiposity. (biovendor.com)
- Of particular interest is that low adiponectin serum levels predict type 2 diabetes independent of other risk factors. (biovendor.com)
- Low serum adiponectin levels are found in patients with coronary artery disease. (biovendor.com)
- Moreover, high circulating levels of adiponectin are associated with decreased risk of myocardial infarction, independent of other factors. (biovendor.com)
- To gain insights into the biology that regulates adiponectin levels, we performed an exome array meta-analysis of 265,780 genetic variants in 67,739 individuals of European, Hispanic, African American, and East Asian ancestry. (dtu.dk)
- To identify potential genes and mechanisms through which the previously unreported association signals act to affect adiponectin levels, we assessed cross-trait associations, expression quantitative trait loci in subcutaneous adipose, and biological pathways of nearby genes. (dtu.dk)
- Taken together, these findings provide further insights into the processes that influence circulating adiponectin levels. (dtu.dk)
- This study in Egypt investigated the association between serum adiponectin levels and pre-eclampsia and between adiponectin levels and some clinical and hormonal parameters. (who.int)
- Serum adiponectin levels in pre-eclamptic women were significantly higher than in normal pregnant women and the increase was more marked in cases of severe pre-eclampsia. (who.int)
- There was a significant negative correlation between adiponectin levels and arterial blood pressure in all groups. (who.int)
- However, there was no correlation between serum adiponectin and proteinuria or estradiol and progesterone levels. (who.int)
- A single bout of t'ai chi (TC) exercise was previously found to be associated with a significant increase in post-exercise adiponectin levels in individuals with cardiovascular risk factors. (eurekamag.com)
- The objective of this study was to examine the long-term effects of 24-month habitual TC exercise on adiponectin levels, glucose homeostasis, lipid profile, and atherosclerotic burden in individuals with cardiovascular risk factors. (eurekamag.com)
- The results of the present study indicate that for individuals with at least one cardiovascular risk factor, engaging in habitual TC exercise could lead to favorable changes in levels of adiponectin. (eurekamag.com)
- Adiponectin exhibits cardioprotective properties in experimental studies, but elevated levels have been linked to increased mortality in older adults and patients with chronic heart failure (HF). (elsevier.com)
- High levels of adiponectin may mark or mediate age-related processes that lead to HF in older adults. (elsevier.com)
- Maybe it's your Adiponectin Levels? (susandopart.com)
- One study showed adiponectin levels rose 260% after 2-3 bouts of exercise and stayed elevated for a few weeks. (susandopart.com)
- Fourteen different studies have shown that fish oil moderately increases adiponectin levels. (susandopart.com)
- More research is needed but in the meantime the take home message is lifestyle modification can be helpful in treating adiponectin levels, which can help other hormone imbalances, such as insulin resistance leading to weight loss. (susandopart.com)
- HFD feeding induced cardiac insulin resistance in Ad-KO mice, which was reversed following replenishment of normal circulating adiponectin levels. (biomedcentral.com)
- In addition, myocardial total triglyceride was elevated by HFD and lipidomic analysis showed increased levels of ceramides and sphingosine-1-phosphate (S1P), with only the latter being corrected by adiponectin administration. (biomedcentral.com)
- Circulating adiponectin (Ad) levels correlate negatively with visceral obesity, diabetes and cardiovascular diseases [ 5 ]. (biomedcentral.com)
- In adults, levels of Adiponectin are inversely correlated with body fat percentage. (slimmersweekly.com)
- Thereafter, adiponectin levels increased prior to occurrence of systolic dysfunction. (biomedcentral.com)
- Initial evidence from clinical studies showed that exposure to angiotensin II receptor blockers increased circulating levels of adiponectin. (biomedcentral.com)
- In this study, we examined whether serum and tissue adiponectin levels are associated with onset of heart failure from hypertension through left ventricular hypertrophy in rats in comparison with other known biomarkers for heart function and inflammation. (biomedcentral.com)
- Obstructive sleep apnea (OSA) has been suggested to be associated with low levels of adiponectin. (docksci.com)
- The present meta-analysis was performed to determine whether CPAP therapy could increase adiponectin levels. (docksci.com)
- The meta-analysis showed that there was no change of adiponectin levels before and after CPAP treatment in OSA patients (SMD = 0.059, 95% confidence interval (CI) = −0.250 to 0.368, z = 0.37, p = 0.710). (docksci.com)
- It has been suggested that reduced serum adiponectin levels could partly explain increased cardiovascular disease in OSA patients. (docksci.com)
- Previous studies showed that OSA was associated with significant decrease in serum adiponectin levels[6-8]. (docksci.com)
- However, whether serum adiponectin levels may be ameliorated or not by CPAP is unclear. (docksci.com)
- The aim of the present meta-analysis was to quantitatively evaluate the impact of CPAP on adiponectin levels in OSA patients. (docksci.com)
- The quantitative sandwich ELISA technique of this kit is based on adiponectin antibody-adiponectin antigen interactions and an HRP colorimetric detection system to detect the levels of adiponectin in samples. (cusabio.com)
- Low plasma levels of adiponectin, also known as hypoadiponectinemia, are linked to the increased prevalence of obesity-associated diseases, including type 2 diabetes, coronary heart disease, and hypertension. (cusabio.com)
- The negative correlation of adiponectin levels and visceral adiposity is stronger than between adiponectin levels and subcutaneous adiposity [13,14] , and higher concentrations were found in females compared to men. (ommegaonline.org)
- Subsequent studies revealed that serum adiponectin levels correlated negatively with visceral fat area(VFA) determined by CT [15] . (ommegaonline.org)
- In obese individuals, circulating adiponectin levels correlated negatively with VFA, but not with BMI or subcutaneous fat area (SFA) [16] , suggesting that serum adiponectin concentrations are related to visceral adiposity. (ommegaonline.org)
- This study was planned to investigate the effect of coenzyme Q10 (CoQ10) supplementation on glycaemic control, oxidative stress (OS), and adiponectin levels in type 2 diabetic (T2DM) patients. (eaglebio.com)
- It is the first study on diabetic patients focused on evaluating the effect of CoQ10 on adiponectin levels. (eaglebio.com)
- In conclusion, after eight weeks of supplementation with CoQ10 , it may reduce OS in T2DM patients but it may not change glycaemic control and adiponectin levels. (eaglebio.com)
- Enhancing Adiponectin levels might reduce body fat levels. (rehobothstarfishing.com)
- This study aimed to determine the association of interleukin (IL)-10 and adiponectin (Ad) levels with the angiographic severity of coronary artery disease (CAD). (ijcva.com)
- By investigating paired subcutaneous (SAT) and visceral adipose tissue (VAT) as well as blood (cell) samples of GDM-affected ( n = 25) vs. matched control ( n = 30) mother-child dyads of the prospective " EaCH " cohort study, we addressed whether alterations of adiponectin plasma, mRNA, and DNA methylation levels are associated with GDM and offspring characteristics. (biomedcentral.com)
- Total serum adiponectin levels were measured by immunoassay. (who.int)
- Before understanding the different glucose tests like HbA1c, fasting blood glucose, insulin resistance score and adiponectin, let's look at some of the causes of abnormal blood sugar levels. (medchunk.com)
- In obese men, reduction in adiponectin levels may partly decipher the multitudinous pathways linking obesity-mediated metabolic disturbances, inflammation, and male infertility or subfertility. (iscience.in)
- This study aims to compare the differences in circulating adiponectin levels and their relationships to regional adiposity , insulin resistance , serum lipid , and inflammatory factors in young, healthy Japanese women with different physical activity statuses. (bvsalud.org)
- No significant difference was observed between the sedentary and trained women in terms of adiponectin levels. (bvsalud.org)
- Our results suggest that elevated levels of circulating adiponectin are associated with decreased subsequent risk of RCC. (arctichealth.org)
- CLA reduces the body's cancer-fighting levels of adiponectin. (ourdogsworld101.com)
- Serum adiponectin levels were measured using radioimmunoassay. (who.int)
- Adiponectin levels decreased with increasing severity of NAFLD. (who.int)
- Interpretation & conclusion: NAFLD is associated with lower serum adiponectin levels independent of conventional cardiovascular risk factors in Asian Indians known to have high prevalence of diabetes and coronary artery disease. (who.int)
- It does so by helping you to burn calories, improve lean mass levels and switching on important fat burning hormones such as adiponectin [5]. (testofuel.com)
- Monounsaturated fat increases a hormone called adiponectin, which helps to regulate blood sugar levels that were disrupted by the previous night's alcohol consumption. (charlottesbook.com)
- Flavonoids contained in Kaempferia parviflora also increase secretion of adiponectin - a hormone that regulates glucose levels and fatty acid breakdown - in in vitro tests. (humanclinicals.org)
Concentrations8
- Niacin (nicotinic acid) has recently been shown to increase serum adiponectin concentrations in men with the metabolic syndrome. (nih.gov)
- Initial in vivo studies in rats demonstrated that niacin (30 mg/kg po) acutely increases serum adiponectin concentrations, whereas it decreases NEFAs. (nih.gov)
- To further substantiate these in vitro findings, wild-type and GPR109A receptor knockout mice were administered a single dose of niacin or placebo, and serum was obtained for the determination of adiponectin and NEFA concentrations. (nih.gov)
- Serum adiponectin concentrations increased and serum NEFAs decreased in the wild-type mice within 10 min following niacin administration. (nih.gov)
- However, niacin administration had no effect on adiponectin and NEFA concentrations in the GPR109A receptor knockout mice. (nih.gov)
- The relations of total and HMW adiponectin with HF were nonlinear, with significant associations observed only for concentrations greater than the median (12.4 and 6.2 mg/L, respectively). (elsevier.com)
- After adjustment for potential confounders, the hazard ratios per SD increment in total adiponectin were 0.93 (95% confidence interval 0.72 to 1.21) for concentrations less than the median and 1.25 (95% confidence interval 1.14 to 1.38) higher than the median. (elsevier.com)
- In conclusion, total and HMW adiponectin showed comparable relations with incident HF in this older cohort, with a threshold effect of increasing risk occurring at their median concentrations. (elsevier.com)
Recombinant2
- This product is manufactured by BioVision, an Abcam company and was previously called 4902 Adiponectin, murine recombinant. (abcam.com)
- 6-week-old male adiponectin knock out (Ad-KO) mice were fed chow or 60% HFD for 6 weeks then received saline or recombinant adiponectin (3μg/g body weight) for an additional 2 weeks. (biomedcentral.com)
Coronary artery1
- Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes. (cdc.gov)
Hormone7
- Adiponectin (ADP) is an adipocyte hormone involved in glucose and lipid metabolism. (elsevier.com)
- Adiponectin (Ad) is one such marker which is a 30-kDa peptide hormone exclusively secreted by adipose tissue. (ijcva.com)
- These potential signaling mediators include glucose, free fatty acids, autonomic nerves, fat-derived hormones (eg, adiponectin), and the gut hormone glucagonlike peptide-1 (GLP-1). (medscape.com)
- And a study from Korea found that they boosted secretion by fat cells of the hormone adiponectin, which regulates the processing of sugar and fats. (drweil.com)
- The fatderived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. (medecinesciences.org)
- 2003. Adiponectin: more than just another fat cell hormone? (csic.es)
- It is also an excellent SARM to prevent muscle loss due to the increased fat-burning qualities of ostarine by decreasing the production of the hormone adiponectin, best sarms dealers. (socalsendy.com)
Metabolic5
- Adiponectin has been shown to have beneficial cardioprotective effects, including direct metabolic, insulin-sensitizing, and anti-apoptotic effects [ 5 ]. (biomedcentral.com)
- Through its receptor AdipoR1 and AdipoR2, adiponectin signaling is involved in numerous essential regulatory cellular signaling mechanisms including AMPK, p38/MAPK signaling, STAT3, and lipid metabolic pathways. (cusabio.com)
- Adiponectin critically contributes to metabolic homeostasis, especially by insulin-sensitizing action. (biomedcentral.com)
- Lifestyle plus exercise intervention improves metabolic syndrome markers without change in adiponectin in obese girls. (bvsalud.org)
- Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations. (cdc.gov)
Adipose2
- No difference for adiponectin distribution among visceral adipose tissues was found. (biomedcentral.com)
- Under normal conditions the adiponectin gene (apM1) is expressed exclusively in adipose tissue. (ommegaonline.org)
Adipocytes2
- Further in vitro studies demonstrated an increase in adiponectin secretion and a decrease in lipolysis in primary adipocytes following treatment with niacin or beta-hydroxybutyrate (an endogenous ligand of the GPR109A receptor), but these effects were blocked when adipocytes were pretreated with pertussis toxin. (nih.gov)
- Niacin had no effect on adiponectin secretion or lipolysis in 3T3-L1 adipocytes, which have limited cell surface expression of the GPR109A receptor. (nih.gov)
Secretion of adiponectin1
- However, little is known about the mechanism(s) by which niacin regulates the intracellular trafficking and secretion of adiponectin. (nih.gov)
Obesity1
- These findings provide the strongest evidence to date, suggesting that the association between obesity and RCC is mediated at least in part through the effects of low adiponectin. (arctichealth.org)
Circulating1
- Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. (biovendor.com)
Globular domain1
- Mouse globular domain Adiponectin expressed in E. coli. (universalbiologicals.com)
Total adiponectin1
- The concentration of total adiponectin converted to monomeric form, ranged from 5 to 30 μg/mL. (ommegaonline.org)
Increase adiponectin1
- This research is still in the very early stages but a few studies exist which reveal how one can increase adiponectin. (susandopart.com)
ELISA Kit1
- This Adiponectin ELISA Kit is a quick, simple, and sensitive assay for the quantitative determination of human adiponectin in human serum and plasma. (eaglebio.com)
Proteins1
- Adiponectin migrated to a high molecular weight position in western blotting under non-denatured condition or in western blotting of fractionated plasma by gel filtration chromatography [12] , suggesting the formation of high-ordered structure and/or binding to other plasma proteins. (ommegaonline.org)
Regulates1
- Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. (medecinesciences.org)
AdipoR21
- AdipoR1 is a receptor for globular adiponectin and is abundantly expressed in skeletal muscle, whereas AdipoR2,a receptor for full-length adiponectin, is mainly expressed in the liver. (ommegaonline.org)
Diabetes4
- 1 ) in this issue of Diabetes Care regarding adiponectin in youth. (diabetesjournals.org)
- Adiponectin is a fat tissue-derived adipokine with beneficial effects against diabetes, cardiovascular diseases, and cancer. (phoenixpeptide.com)
- Discovery of Adiponectin and its Future Prospect (2014) J Diabetes Obes 1(1): 8- 13. (ommegaonline.org)
- Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes. (cdc.gov)
Correlation1
- The correlation of LFM and a favorable lipid profile against CVD and adiponectin is likely involved in this association . (bvsalud.org)
Receptor 1 gene2
- Similar to adiponectin, ADP-1 increased the expression of the adiponectin receptor 1 gene. (phoenixpeptide.com)
- Association between adiponectin receptor 1 gene polymorphism and insulin resistance in Chinese patients with polycystic ovary syndrome. (cdc.gov)
Biologically active1
- Because of limitations in production of biologically active adiponectin, adiponectin-mimetic AdipoRs' agonists have been suggested as alternative ways to expand the opportunity to develop anti-diabetic agents. (phoenixpeptide.com)
Collagen domain1
- A collagen domain-derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms. (phoenixpeptide.com)
Systolic dysfunction1
- Consistent with the HF findings, higher adiponectin tended to be associated with left ventricular systolic dysfunction and left atrial enlargement. (elsevier.com)
Negatively associated2
- Triglyceride in the sedentary women was closely and negatively associated with adiponectin , as well as PAI-1 in the trained women . (bvsalud.org)
- Multiple logistic regression analysis revealed adiponectin to be negatively associated with NAFLD [Odds Ratio (OR): 0.865, 95% Confidence Interval (CI): 0.792- 0.944, P=0.001]. (who.int)
Gene1
- Adiponectin gene polymorphisms and acute respiratory distress syndrome susceptibility and mortality. (cdc.gov)
Homeostasis1
- Measurements on adiponectin, glucose homeostasis, lipid profile, and atherosclerotic burden were made at three time points-baseline, 12 months, and 24 months. (eurekamag.com)
High-molecular weight2
- The aim of this study was to investigate the associations of total and high-molecular weight (HMW) adiponectin with incident HF (n = 780) and, in a subset, echocardiographic parameters in a community-based cohort of adults aged ≥65 years. (elsevier.com)
- Adiponectin, which exists in serum in three major complexes including trimer, hexamer, and the high molecular weight (HMW) form, has strong insulin sensitizing, anti-inflammatory and anti-diabetic functions. (unm.edu)
Cardiovascular diseases2
- Adiponectin is reported to relate with cardiovascular diseases, we sought to examine whether adiponectin is associated with disease progression of heart failure from hypertension in rats in comparison with other known biomarkers and echocardiographic parameters. (biomedcentral.com)
- Furthermore, LFM was associated with a favorable lipid profile against cardiovascular diseases (CVDs) in the whole study cohort, but this association became insignificant when adiponectin was taken into account. (bvsalud.org)
Fatty2
- To our knowledge this is the first report on identification of a short peptidefrom adiponectin with positive effects on glucose or fatty acid metabolism. (phoenixpeptide.com)
- Background & objective: Association between adiponectin and non-alcoholic fatty liver disease (NAFLD) has been reported in west. (who.int)
Anti-atherogenic2
- Adiponectin has profound insulin-sensitizing, anti-inflammatory and anti-atherogenic effects. (who.int)
- Since its discovery, numerous experimental and clinical studies have demonstrated that adiponectin has anti-atherogenic, antidiabetic and anti-inflammatory properties. (ommegaonline.org)
Metabolism2
- Conclusions Reduced adiponectin seems to be a pathogenic co-factor in GDM, even independent of BMI, affecting materno-fetal metabolism. (biomedcentral.com)
- Collectively, adiponectin appears to be not only a specific factor for regulating materno-fetal metabolism but also an important candidate in GDM pathophysiology. (biomedcentral.com)
Platelet1
- Adiponectin diminishes platelet aggregation and sCD40L release. (core.ac.uk)
Secretory1
- We never implied that a direct effect of adiponectin on insulin secretory function exists. (diabetesjournals.org)