A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.
Cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
A 12-kDa cysteine-rich polypeptide hormone secreted by FAT CELLS in the ADIPOSE TISSUE. It is the founding member of the resistin-like molecule (RELM) hormone family. Resistin suppresses the ability of INSULIN to stimulate cellular GLUCOSE uptake.
Polypeptides produced by the ADIPOCYTES. They include LEPTIN; ADIPONECTIN; RESISTIN; and many cytokines of the immune system, such as TUMOR NECROSIS FACTOR-ALPHA; INTERLEUKIN-6; and COMPLEMENT FACTOR D (also known as ADIPSIN). They have potent autocrine, paracrine, and endocrine functions.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
A continuous cell line that is a substrain of SWISS 3T3 CELLS developed though clonal isolation. The mouse fibroblast cells undergo an adipose-like conversion as they move to a confluent and contact-inhibited state.
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Glucose in blood.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.
The amount of fat or lipid deposit at a site or an organ in the body, an indicator of body fat status.
Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.
THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).
Fatty tissue inside the ABDOMINAL CAVITY, including visceral fat and retroperitoneal fat. It is the most metabolically active fat in the body and easily accessible for LIPOLYSIS. Increased visceral fat is associated with metabolic complications of OBESITY.
Fatty tissue under the SKIN through out the body.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
An enzyme that catalyzes the phosphorylation of AMP to ADP in the presence of ATP or inorganic triphosphate. EC 2.7.4.3.
Mutant mice exhibiting a marked obesity coupled with overeating, hyperglycemia, hyperinsulinemia, marked insulin resistance, and infertility when in a homozygous state. They may be inbred or hybrid.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Substances which lower blood glucose levels.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).
The sum of the weight of all the atoms in a molecule.
The relative amounts of various components in the body, such as percentage of body fat.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Hormones released from neoplasms or from other cells that are not the usual sources of hormones.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Fatty tissue composed of WHITE ADIPOCYTES and generally found directly under the skin (SUBCUTANEOUS FAT) and around the internal organs (ABDOMINAL FAT). It has less vascularization and less coloration than the BROWN FAT. White fat provides heat insulation, mechanical cushion, and source of energy.
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
The measurement around the body at the level of the ABDOMEN and just above the hip bone. The measurement is usually taken immediately after exhalation.
Fatty tissue in the region of the ABDOMEN. It includes the ABDOMINAL SUBCUTANEOUS FAT and the INTRA-ABDOMINAL FAT.
The waist circumference measurement divided by the hip circumference measurement. For both men and women, a waist-to-hip ratio (WHR) of 1.0 or higher is considered "at risk" for undesirable health consequences, such as heart disease and ailments associated with OVERWEIGHT. A healthy WHR is 0.90 or less for men, and 0.80 or less for women. (National Center for Chronic Disease Prevention and Health Promotion, 2004)
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.
A publication issued at stated, more or less regular, intervals.
Individual's rights to obtain and use information collected or generated by others.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.

Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity. (1/2639)

Obesity which is defined as accumulation of excess body fat, is a major cause of atherosclerotic vascular disease in industrial countries. Recent advances in the biology of adipose tissue have revealed that adipose tissue is not simply an energy storage organ but it also secretes a variety of molecules which affect the metabolism of the whole body. Through a systematic search of active genes in adipose tissue, we found that adipose tissue, especially visceral fat expressed numerous genes for secretory proteins (about 30% of total genes analyzed). Among them, plasminogen activator-1 (PAI-1), which is a regulator of the fibrinolytic system, was overexpressed in the visceral fat in an animal model of obesity. Plasma levels of PAI-1 were closely correlated with visceral fat adiposity. Thus, PAI-1 secreted from visceral fat may play some role in thrombotic vascular disease in visceral obesity. Adiponectin, a novel adipose-specific gene product, which has a matrix-like structure, is abundantly present in the bloodstream. Dysregulated secretion of adiponectin may be related to vascular disease in obesity. Biologically active molecules secreted from adipose tissue (adipocytokines) may have important roles in the development of atherosclerotic disease in obesity.  (+info)

Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. (2/2639)

Insulin stimulates adipose cells both to secrete proteins and to translocate the GLUT4 glucose transporter from an intracellular compartment to the plasma membrane. We demonstrate that whereas insulin stimulation of 3T3-L1 adipocytes has no effect on secretion of the alpha3 chain of type VI collagen, secretion of the protein hormone adipocyte complement related protein of 30 kD (ACRP30) is markedly enhanced. Like GLUT4, regulated exocytosis of ACRP30 appears to require phosphatidylinositol-3-kinase activity, since insulin-stimulated ACRP30 secretion is blocked by pharmacologic inhibitors of this enzyme. Thus, 3T3-L1 adipocytes possess a regulated secretory compartment containing ACRP30. Whether GLUT4 recycles to such a compartment has been controversial. We present deconvolution immunofluorescence microscopy data demonstrating that the subcellular distributions of ACRP30 and GLUT4 are distinct and nonoverlapping; in contrast, those of GLUT4 and the transferrin receptor overlap. Together with supporting evidence that GLUT4 does not recycle to a secretory compartment via the trans-Golgi network, we conclude that there are at least two compartments that undergo insulin-stimulated exocytosis in 3T3-L1 adipocytes: one for ACRP30 secretion and one for GLUT4 translocation.  (+info)

Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. (3/2639)

BACKGROUND: Among the many adipocyte-derived endocrine factors, we recently found an adipocyte-specific secretory protein, adiponectin, which was decreased in obesity. Although obesity is associated with increased cardiovascular mortality and morbidity, the molecular basis for the link between obesity and vascular disease has not been fully clarified. The present study investigated whether adiponectin could modulate endothelial function and relate to coronary disease. METHODS AND RESULTS: For the in vitro study, human aortic endothelial cells (HAECs) were preincubated for 18 hours with the indicated amount of adiponectin, then exposed to tumor necrosis factor-alpha (TNF-alpha) (10 U/mL) or vehicle for the times indicated. The adhesion of human monocytic cell line THP-1 cells to HAECs was determined by adhesion assay. The surface expression of vascular cell adhesion molecule-1 (VCAM-1), endothelial-leukocyte adhesion molecule-1 (E-selectin), and intracellular adhesion molecule-1 (ICAM-1) was measured by cell ELISA. Physiological concentrations of adiponectin dose-dependently inhibited TNF-alpha-induced THP-1 adhesion and expression of VCAM-1, E-selectin, and ICAM-1 on HAECs. For the in vivo study, the concentrations of adiponectin in human plasma were determined by a sandwich ELISA system that we recently developed. Plasma adiponectin concentrations were significantly lower in patients with coronary artery disease than those in age- and body mass index-adjusted control subjects. CONCLUSIONS: These observations suggest that adiponectin modulates endothelial inflammatory response and that the measurement of plasma adiponectin levels may be helpful in assessment of CAD risk.  (+info)

Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. (4/2639)

Adiponectin is a novel, adipose-specific protein abundantly present in the circulation, and it has antiatherogenic properties. We analyzed the plasma adiponectin concentrations in age- and body mass index (BMI)-matched nondiabetic and type 2 diabetic subjects with and without coronary artery disease (CAD). Plasma levels of adiponectin in the diabetic subjects without CAD were lower than those in nondiabetic subjects (6.6+/-0.4 versus 7.9+/-0.5 microg/mL in men, 7.6+/-0.7 versus 11.7+/-1.0 microg/mL in women; P<0.001). The plasma adiponectin concentrations of diabetic patients with CAD were lower than those of diabetic patients without CAD (4.0+/-0.4 versus 6.6+/-0.4 microg/mL, P<0.001 in men; 6.3+/-0.8 versus 7.6+/-0. 7 microg/mL in women). In contrast, plasma levels of leptin did not differ between diabetic patients with and without CAD. The presence of microangiopathy did not affect the plasma adiponectin levels in diabetic patients. Significant, univariate, inverse correlations were observed between adiponectin levels and fasting plasma insulin (r=-0.18, P<0.01) and glucose (r=-0.26, P<0.001) levels. In multivariate analysis, plasma insulin did not independently affect the plasma adiponectin levels. BMI, serum triglyceride concentration, and the presence of diabetes or CAD remained significantly related to plasma adiponectin concentrations. Weight reduction significantly elevated plasma adiponectin levels in the diabetic subjects as well as the nondiabetic subjects. These results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy.  (+info)

Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. (5/2639)

We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses. Adiponectin suppressed colony formation from colony-forming units (CFU)-granulocyte-macrophage, CFU-macrophage, and CFU-granulocyte, whereas it had no effect on that of burst-forming units-erythroid or mixed erythroid-myeloid CFU. In addition, adiponectin inhibited proliferation of 4 of 9 myeloid cell lines but did not suppress proliferation of erythroid or lymphoid cell lines except for one cell line. These results suggest that adiponectin predominantly inhibits proliferation of myelomonocytic lineage cells. At least one mechanism of the growth inhibition is induction of apoptosis because treatment of acute myelomonocytic leukemia lines with adiponectin induced the appearance of subdiploid peaks and oligonucleosomal DNA fragmentation. Aside from inhibiting growth of myelomonocytic progenitors, adiponectin suppressed mature macrophage functions. Treatment of cultured macrophages with adiponectin significantly inhibited their phagocytic activity and their lipopolysaccharide-induced production of tumor necrosis factor alpha. Suppression of phagocytosis by adiponectin is mediated by one of the complement C1q receptors, C1qRp, because this function was completely abrogated by the addition of an anti-C1qRp monoclonal antibody. These observations suggest that adiponectin is an important negative regulator in hematopoiesis and immune systems and raise the possibility that it may be involved in ending inflammatory responses through its inhibitory functions. (Blood. 2000;96:1723-1732)  (+info)

Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. (6/2639)

BACKGROUND: Among the many adipocyte-derived endocrine factors, we found an adipocyte-derived plasma protein, adiponectin, that was decreased in obesity. We recently demonstrated that adiponectin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced expression of endothelial adhesion molecules and that plasma adiponectin level was reduced in patients with coronary artery disease (CIRCULATION: 1999;100:2473-2476). However, the intracellular signal by which adiponectin suppressed adhesion molecule expression was not elucidated. The present study investigated the mechanism of modulation for endothelial function by adiponectin. METHODS AND RESULTS: The interaction between adiponectin and human aortic endothelial cells (HAECs) was estimated by cell ELISA using biotinylated adiponectin. HAECs were preincubated for 18 hours with 50 microg/mL of adiponectin, then exposed to TNF-alpha (10 U/mL) or vehicle for the times indicated. NF-kappaB-DNA binding activity was determined by electrophoretic mobility shift assays. TNF-alpha-inducible phosphorylation signals were detected by immunoblotting. Adiponectin specifically bound to HAECs in a saturable manner and inhibited TNF-alpha-induced mRNA expression of monocyte adhesion molecules without affecting the interaction between TNF-alpha and its receptors. Adiponectin suppressed TNF-alpha-induced IkappaB-alpha phosphorylation and subsequent NF-kappaB activation without affecting other TNF-alpha-mediated phosphorylation signals, including Jun N-terminal kinase, p38 kinase, and Akt kinase. This inhibitory effect of adiponectin is accompanied by cAMP accumulation and is blocked by either adenylate cyclase inhibitor or protein kinase A (PKA) inhibitor. CONCLUSIONS: These observations raise the possibility that adiponectin, which is naturally present in the blood stream, modulates the inflammatory response of endothelial cells through cross talk between cAMP-PKA and NF-kappaB signaling pathways.  (+info)

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. (7/2639)

Adipocyte complement-related protein (30 kDa) (Acrp30), a secreted protein of unknown function, is exclusively expressed in differentiated adipocytes; its mRNA is decreased in obese humans and mice. Here we describe novel pharmacological properties of the protease-generated globular head domain of Acrp30 (gAcrp30). Acute treatment of mice with gAcrp30 significantly decreased the elevated levels of plasma free fatty acids caused either by administration of a high fat test meal or by i.v. injection of Intralipid. This effect of gAcrp30 was caused, at least in part, by an acute increase in fatty acid oxidation by muscle. As a result, daily administration of a very low dose of gAcrp30 to mice consuming a high-fat/sucrose diet caused profound and sustainable weight reduction without affecting food intake. Thus, gAcrp30 is a novel pharmacological compound that controls energy homeostasis and exerts its effect primarily at the peripheral level.  (+info)

Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. (8/2639)

BACKGROUND: Excessive lipid accumulation in macrophages plays an important role in the development of atherosclerosis. Recently, we discovered an adipocyte-specific plasma protein, adiponectin, that is decreased in patients with coronary artery disease. We previously demonstrated that adiponectin acts as a modulator for proinflammatory stimuli and inhibits monocyte adhesion to endothelial cells. The present study investigated the effects of adiponectin on lipid accumulation in human monocyte-derived macrophages. METHODS AND RESULTS: Human monocytes were differentiated into macrophages by incubation in human type AB serum for 7 days, and the effects of adiponectin were investigated at different time intervals. Treatment with physiological concentrations of adiponectin reduced intracellular cholesteryl ester content, as determined using the enzymatic, fluorometric method. The adiponectin-treated macrophages contained fewer lipid droplets stained by oil red O. Adiponectin suppressed the expression of the class A macrophage scavenger receptor (MSR) at both mRNA and protein levels by Northern and immunoblot analyses, respectively, without affecting the expression of CD36, which was quantified by flow cytometry. Adiponectin reduced the class A MSR promoter activity, as measured by luciferase reporter assay. Adiponectin treatment dose-dependently decreased class A MSR ligand binding and uptake activities. The mRNA level of lipoprotein lipase as a marker of macrophage differentiation was decreased by adiponectin treatment, but that of apolipoprotein E was not altered. Adiponectin was detected around macrophages in the human injured aorta by immunohistochemistry. CONCLUSIONS: The adipocyte-derived plasma protein adiponectin suppressed macrophage-to-foam cell transformation, suggesting that adiponectin may act as a modulator for macrophage-to-foam cell transformation.  (+info)

Adiposity is known to be related to asthma. Although a causal link between adiponectin (a protein produced by adipose tissue) and asthma has been demonstrated in mice,. Low serum adiponectin levels predict an increased future risk for developing asthma in middle-aged women, particularly among smokers, according to a new study.. the evidence in humans has been conflicting, said lead author Akshay Sood, MD, MPH, associate professor in the Division of Pulmonary and Critical Care Medicine at the University of New Mexico Health Sciences Center School of Medicine.. In an earlier cross-sectional study, we found an association between low serum adiponectin levels and prevalent asthma among women, but the direction of this association is not known, Dr. Sood continued. In the current study, we examined the longitudinal association between asthma and adiponectin and found that low serum adiponectin concentrations, independent of obesity, predicted a higher risk for developing asthma.. The findings ...
Insulin resistance (IR) and related metabolic disturbances are characterized by low levels of adiponectin. High molecular weight adiponectin (HMWA) is considered the active form of adiponectin and a better marker of IR than total adiponectin. The objective of this study is to compare the utility of total adiponectin, HMWA and the HMWA/total adiponectin index (SA index) for the identification of IR and related metabolic conditions. A cross-sectional analysis was performed in a group of ambulatory subjects, aged 20 to 70 years, in Mexico City. Areas under the receiver operator characteristic (ROC) curve for total, HMWA and the SA index were plotted for the identification of metabolic disturbances. Sensitivity and specificity, positive and negative predictive values, and accuracy for the identification of IR were calculated. The study included 101 men and 168 women. The areas under the ROC curve for total and HMWA for the identification of IR (0.664 vs. 0.669, P = 0.74), obesity (0.592 vs. 0.610, P = 0.32)
Murine models have also shown that subcutaneous injection of adiponectin in ovalbumin-sensitised mice prevents the subsequent development of increased airway responsiveness on exposure to ovalbumin.10 31 Taken together, the known anti-inflammatory effects of adiponectin in both mice and humans and the prevention of both allergen-induced airway responsiveness and airway smooth muscle proliferation in murine models has led to the hypothesis that the decreased serum concentrations of adiponectin in obese humans may contribute to the propensity towards asthma in this population.30. This study suggests that a higher serum adiponectin concentration may be a protective factor for current asthma in women, particularly those who are premenopausal. The observed association was independent of adiposity. These results are consistent with a previous cross-sectional study from a different population that suggested that high serum concentrations of leptin, another adipokine, are an independent risk factor for ...
Atherosclerosis is the primary cause of coronary artery disease (CAD). There is increasing recognition that lesion composition rather than size determines the acute complications of atherosclerotic disease. Low serum adiponectin levels were reported to be associated with coronary artery disease and future incidence of acute coronary syndrome (ACS). The impact of adiponectin on lesion composition still remains to be determined. We measured serum adiponectin levels in 303 patients with stable typical or atypical chest pain, who underwent dual-source multi-slice CT-angiography to exclude coronary artery stenosis. Atherosclerotic plaques were classified as calcified, mixed or non-calcified. In bivariate analysis adiponectin levels were inversely correlated with total coronary plaque burden (r = -0.21, p = 0.0004), mixed (r = -0.20, p = 0.0007) and non-calcified plaques (r = -0.18, p = 0.003). No correlation was seen with calcified plaques (r = -0.05, p = 0.39). In a fully adjusted multivariate model ...
TY - JOUR. T1 - Longitudinal changes in the relationship between serum adiponectin concentration and cardiovascular risk factors among apparently healthy middle-aged adults. AU - Niu, Kaijun. AU - Kobayashi, Yoritoshi. AU - Guan, Lei. AU - Momma, Haruki. AU - Guo, Hui. AU - Cui, Yufei. AU - Otomo, Atsushi. AU - Chujo, Masahiko. AU - Nagatomi, Ryoichi. PY - 2013/9/1. Y1 - 2013/9/1. KW - Adiponectin. KW - Cardiovascular disease risk factors. KW - Longitudinal study. UR - http://www.scopus.com/inward/record.url?scp=84883266773&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84883266773&partnerID=8YFLogxK. U2 - 10.1016/j.ijcard.2012.11.020. DO - 10.1016/j.ijcard.2012.11.020. M3 - Article. C2 - 23182006. AN - SCOPUS:84883266773. VL - 167. SP - 2318. EP - 2320. JO - International Journal of Cardiology. JF - International Journal of Cardiology. SN - 0167-5273. IS - 5. ER - ...
As mentioned above, both antidiabetic treatments inhibited the development of hypoadiponectinemia during the animal experiment (Figure 1).. Generally, the effect of insulin on adiponectin serum levels is contentious. In vitro, insulin inhibits the expression of adiponectin at mRNA level [35], but then it leads to an increased adiponectin secretion from adipocytes [36, 37]. In vivo, there is a good documented association of hypoadiponectinemia with insulin resistance and diabetes mellitus type 2 [38], but the effect of insulin therapy on serum levels of adiponectin is not well studied so far. A study in five healthy male volunteers showed a decrease of adiponectin levels during a hyperinsulinemic euglycemic clamp [39]. Another study with insulin treatment in a murine model of obesity and diabetes mellitus type 2, the db/db mice, suggested no impact on adiponectin levels [40]. A recent study indicates an elevation of adiponectin levels in a hyperinsulinemia rat model [41]. In this respect, our ...
Adiponectin is an adipocyte-specific protein that plays a role in obesity, insulin resistant, lipid metabolism, and anti-inflammation. Hypoadiponectinemia may be associated with a higher risk for type 2 diabetes and cardiovascular disease. Some studies suggest that adiponectin levels are modulated by lifestyle factors, but little is known about the associations between lifestyle factors and plasma adiponectin levels in Japanese people. We therefore investigated the associations between lifestyle factors and plasma adiponectin levels in general Japanese men. The subjects were 202 Japanese male workers who participated in an annual health check. They provided details about anthropometrical data, blood collection, their use of prescribed medication, and the clinical history of their families. They also completed a self-administered questionnaire about their lifestyles. Subjects with plasma adiponectin levels below 4.0 μg/ml had significantly lower levels of HDL cholesterol and higher levels of BMI, SBP,
TY - JOUR. T1 - The Significance of Elevated Adiponectin in the Treatment of Type 2 Diabetes. AU - Combs, Terry P.. AU - Scherer, Philipp E.. PY - 2003/12/1. Y1 - 2003/12/1. N2 - Thiazolidinediones (TZDs) represent a new family of oral antihyperglycemic agents for insulin resistance and type 2 diabetes. A recently discovered effect of TZDs is the induction of a circulating protein produced exclusively in adipocytes, called Acrp30 or adiponectin. To date, 5 clinical studies have confirmed the induction of circulating adiponectin during TZD treatment. Subjects with type 2 diabetes have lower levels of adiponectin than those without diabetes, yet it is very unlikely that the induction of adiponectin during TZD treatment is a secondary effect of improved glycemia. Highly purified recombinant adiponectin showed very dramatic blood glucose (BG) -lowering effects. The increase in circulating adiponectin during TZD treatment is associated with elevated adiponectin levels in adipose tissue. There is ...
Two independent studies recently demonstrated that there is a modest level of adiponectin expression in C/EBPα-deficient adipocytes with ectopic expression of PPARγ, whereas expression of both PPARγ and C/EBPα led to production of abundant quantities of adiponectin (23,24). These studies suggest that C/EBPα and PPARγ are required to fully activate adiponectin gene expression. Our study indicates that the regulation of adiponectin gene transcription by C/EBPα and PPARγ is through different sites of the human adiponectin gene. C/EBPα increased adiponectin promoter activity only when the DNA encoding the first intron was present (Fig. 2C). In contrast, overexpression of PPARγ2 and its partner RXRα increased the activity of the adiponectin proximal promoter, and this was not enhanced in the presence of the DNA encoding the first intron (Fig. 2B). These data are consistent with the identification of a PPARγ response element within both the human and mouse adiponectin proximal promoter ...
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It is well known that circulating adiponectin concentrations are reduced in animal models of obesity and in patients with obesity or metabolic syndrome, despite adipocyte hypertrophy or increased body fat (2-6). However, the details of adiponectin production and release have varied among studies, especially in animal models (10,28,29,32,33). This is probably due to the apparently different etiology of the three types of obese animal models: genetic, diet-induced, and hypothalamic obesity (20,34).. VMH lesion-induced hypothalamic obesity in animals is the only obesity model that shows clear derangements of autonomic nervous activities (hyperactivity of the vagus nerve and hypoactivity of sympathetic nerves) compared with genetic (20), diet-induced obesity (34), and other types of hypothalamic obesity (19). Thus, there is a possibility that this animal model has different characteristics of adiponectin production and release, with resultant change of serum adiponectin, compared with those of other ...
OBJECTIVE: Obesity-related atherosclerosis is a systemic disease with a background connected to multiple metabolic-neurohumoral pathways. The leptin/adiponectin ratio has been suggested as an atherosclerotic marker in obese patients. The aim of this study was to assess (1) the significance of the L/A ratio in overweight subjects, (2) the relation with anthropometric/metabolic parameters and (3) gender difference. METHOD: The study included 80 adult males and females, overweight, non-diabetic patients. Biochemical blood analysis and anthropometric and cardiovascular measurements were performed. Serum leptin levels were measured with a radioimmunoassay test and total adiponectin levels with enzyme-linked immunosorbent assay. Leptin/adiponectin ratios were calculated as ratios between total serum concentrations of leptin and adiponectin. RESULTS: Differences between leptin, adiponectin serum levels and leptin/adiponectin ratios are presented in overweight persons, where females have a significantly ...
Purpose: : A transgenic mouse model with overexpression of the adipokine adiponectin resulted in progressive expansion of the retrobulbar fat pad leading to fulminant exophthalmos. We undertook a pilot study to determine if adiponectin levels in patients with Graves Ophthalmopathy are elevated as found in the transgenic mouse model. Methods: : From a large urban ophthalmic plastics service 46 consecutive patients with Graves Ophthalmolopathy had their mean serum adiponectin levels determined through an adiponectin ELISA. Clinical data was recorded using standardized criteria. Results: : An ANOVA analysis found that mean adiponectin levels differed significantly between inactive and active Graves disease patients (p=0.0458) and presence of diabetes (p=0.0054). Mean adiponectin level in the active disease group was 15.78 mg/L (SD=8.51), and in the inactive group it was 11.36 mg/L (SD=6.29). Conclusions: : The adipokines such as adiponectin warrant further investigation regarding its role in the ...
A number of bioactive molecules secreted from fat tissue, referred to as adipokines, could participate in the development of obesity-related complications through regulation of inflammatory responses.9,10 Most adipokines are proinflammatory. In contrast, adiponectin, also referred to as adipocyte complement-related protein 30 (ACRP30), is an antiinflammatory adipokine that is abundantly present in blood stream. Whereas adiponectin is expressed almost exclusively in adipose tissue,11,12 plasma adiponectin levels are paradoxically decreased in obese individuals.13 This regulation of adiponectin results, at least in part, from the upregulation of tumor necrosis factor (TNF)-α and other proinflammatory cytokines which inhibits the synthesis of adiponectin in the obese state. Low plasma adiponectin levels, also known as hypoadiponectinemia, are closely associated with the increased prevalence of obesity-linked disorders including type 2 diabetes, coronary heart disease, and hypertension.9 Studies ...
BACKGROUND AND OBJECTIVES: Molecular data suggests that adiponectin may directly regulate urinary albumin excretion. In the Diabetes Prevention Program (DPP) we measured adiponectin and albuminuria before and after intervention, and we previously reported increases in adiponectin with interventions. Here we have used the DPP dataset to test the hypothesis that treatment-related increases in adiponectin may reduce albuminuria in obesity. DESIGN, SETTING, PARTICIPANTS AND METHODS: We evaluated cross-sectional correlations between plasma adiponectin and urinary albumin excretion at baseline, and the relationship of treatment-related changes in adiponectin and albuminuria. Baseline and follow-up urine albumin to creatinine ratios (ACR (albumin to creatinine ratio)) and plasma adiponectin concentration were available in 2553 subjects. RESULTS: Adjusting for age, sex and race/ethnicity, we observed a statistically significant but weak inverse relationship between adiponectin and ACR at baseline (conditional
Background: Adiponectin is an adipokine with beneficial effect on vascular function. Although adiponectin levels are decreased in patients with diabetes mellitus (DM), it is unclear whether impaired glucose tolerance (IGT) affects adiponectins release, or whether glucose intake modifies its release from adipocytes. We examined the effect of glucose on serum adiponectin/insulin and endothelial function, in subjects with IGT, patients with DM and healthy individuals.. Methods: The study population consisted of 113 subjects: 19 with IGT, 78 with DM and 16 controls. All subjects underwent glucose loading (75g oral glucose), and blood samples were obtained at baseline and after 3 hours. Endothelial function was evaluated by gauge-strain plethysmography at baseline and every 1h, and endothelium-dependent dilation (EDD) was determined. Adiponectin and insulin were measured at baseline and at 3h.. Results: Glucose loading increased adiponectin levels in healthy (70.1±8.5 to 80.8±11.4 ng/ml, p,0.05) ...
Abstract: Nitric oxide (NO) stimulates mitochondrial biogenesis. We recently reported that adiponectin synthesis is regulated by mitochondrial function in adipocytes. This study was undertaken to test the hypothesis that endothelial NO synthase (eNOS) plays an important role in adiponectin synthesis by producing NO and enhancing mitochondrial function in adipocytes. We examined the effects of eNOS knockdown on adiponectin synthesis in 3T3-L1 adipocytes and also examined plasma adiponectin levels and the mitochondria in adipose tissue of eNOS knockout (eNOS-/-) mice with and without chronic administration of a NO donor. In cultured 3T3-L1 adipocytes, eNOS siRNA decreased rosiglitazone-induced adiponectin secretion, which was associated with decreases in mitochondrial proteins and biogenesis factors. Plasma adiponectin concentrations were reduced in adult eNOS-/- mice compared with age-matched wild-type mice. Mitochondrial contents in adipose tissue were reduced in eNOS-/- mice, and this was ...
In the current study, we showed that in patients with AMI, low plasma adiponectin was associated independently with increased risk of developing T2DM in a linear dose-response relationship. Even in patients with low glucose, adiponectin still added significantly to the prognostic value, as the risk of developing T2DM was higher in patients with low adiponectin/low glucose compared with patients with high adiponectin/low glucose. However, the risk increased by ∼10-fold in patients who were characterized by the combination of low adiponectin and high blood glucose.. Low plasma adiponectin has been suggested to be causally involved in pathways leading to T2DM. The binding of adiponectin to its receptors (adiR1/R2) directly suppresses hepatic gluconeogenesis and stimulates fatty acid oxidation in liver and muscle, glucose uptake in skeletal muscle, and insulin secretion (1,10).. In a study of 335 cases of incident T2DM from the Whitehall II study, adiponectin was measured three times per ...
Adiponectin is an adipose-derived secreted protein containing 226 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages). Recombinant adiponectin is a multimeric glycoprotein containing amino acids Glu-19 to Asn-244 of the adiponectin precursor protein fused to an N-terminal histidine tag.. ...
Iranian Journal of Diabetes and Obesity is scientific quarterly journal published by Shahid Sadoughi University of Medical Sciences
The data presented are consistent with those of previous studies, demonstrating that adiponectin concentrations are lower in SA individuals (3,4), and show for the first time that this is also true for HMW adiponectin. However, these findings do not necessarily mean that lower total or HMW adiponectin concentration accounts for the increased prevalence of insulin resistance in SA individuals. The difference between the SA and CAU groups occurs because, in contrast to the presence of higher values in CAU-IS compared with -IR women, total and HMW adiponectin concentrations were not higher in IS than IR individuals of SA ancestry. This lack of a difference between the two SA groups occurred despite the fact that the SSPG concentrations were threefold lower in the IS individuals. Thus, the ethnic difference in adiponectin concentrations is due to the fact that adiponectin concentrations remain low in SAs, irrespective of the degree of insulin sensitivity, a finding that does not appear to support ...
Current epidemics of diabetes mellitus is largely caused by wide spread obesity. The best-established connection between obesity and insulin resistance is the elevated and/or dysregulated levels of circulating free fatty acids that cause and aggravate insulin resistance, type 2 diabetes, cardiovascular disease and other hazardous metabolic conditions. Here, we investigated the effect of a major dietary saturated fatty acid, palmitate, on the insulin-sensitizing adipokine adiponectin produced by cultured adipocytes. We have found that palmitate rapidly inhibits transcription of the adiponectin gene and the release of adiponectin from adipocytes. Adiponectin gene expression is controlled primarily by PPARγ and C/EBPα. Using mouse embryonic fibroblasts from C/EBPα-null mice, we have determined that the latter transcription factor may not solely mediate the inhibitory effect of palmitate on adiponectin transcription leaving PPARγ as a likely target of palmitate. In agreement with this model, palmitate
Adipose tissue is now accepted by the scientific and medical community to be a genuine endocrine organ, in addition to its classical role as an energy store. Adiponectin is one of the many adipocytokines that are secreted almost exclusively by adipose tissue. Alteration in blood adiponectin concentrations has been linked to many human diseases in numerous cross-sectional and prospective studies. In this review, we describe briefly the biological effects of adiponectin as revealed by basic scientific investigations. We also summarize the principles of blood adiponectin assays. Overall, lower blood adiponectin concentration is found in subjects with obesity, type 2 diabetes mellitus, dyslipidemia, and hypertension. These medical conditions are components of the metabolic syndrome and major risk factors for accelerated atherosclerosis. Plasma adiponectin levels are also expected to be lower in subjects with cardiovascular diseases, such as coronary artery disease, ischemic stroke and peripheral artery
Background: Adiponectin is a circulating adipose-derived cytokine with anti-inflammatory and antiatherosclerotic properties. Low adiponectin concentrations are related with endothelial dysfunction, hypertension, and incidence of type 2 diabetes. However the relationship of adiponectin concentrations and cardiovascular outcomes in patients with pre-existing cardiovascular disease is unclear.. Methods: We used data from patients enrolled in the prospective, multicentre French registry of Acute ST elevation or non-ST-elevation Myocardial Infarction(Fast-MI). Blood samples were drawn immediately at admission. Adiponectin concentrations were measured using a validated immunoassay (n= 932 patients, of whom 279 with diabetes). Cox proportional hazards regression models were used for assessing outcomes, e.g all-cause mortality and recurrent AMI during a 2-year follow-up, according to adiponectin levels as continuous variable and tertiles.. Results: During follow-up, 162(17%) patients died or had a ...
TY - JOUR. T1 - Inverse association between serum adiponectin level and transaminase activities in Japanese male workers. AU - Yokoyama, Hirokazu. AU - Hirose, Hiroshi. AU - Ohgo, Hideki. AU - Saito, Ikuo. PY - 2004/7. Y1 - 2004/7. N2 - Background/Aims Since a novel polypeptide named adiponectin was shown to prevent the development of steatosis and steatohepatitis in animal models, we studied whether it was also possible in a clinical situation. Methods Associations between serum adiponectin levels and serum transaminase activities were studied in 791 Japanese males who were not heavy drinkers, and had no autoimmune or HBV- or HCV-induced liver diseases. Results Various markers of metabolic diseases including levels of body mass index (BMI), serum triglyceride, total cholesterol, and insulin resistance assessed by the homeostasis model were significantly higher in subjects with increased transaminase activities when compared to those with normal activities. Single regression analyses ...
TY - JOUR. T1 - Association of low serum adiponectin levels with erosive esophagitis in men. T2 - An analysis of 2405 subjects undergoing physical check-ups. AU - Kato, Motohiko. AU - Watabe, Kenji. AU - Hamasaki, Toshimitsu. AU - Umeda, Miyuki. AU - Furubayashi, Aiko. AU - Kinoshita, Kazuo. AU - Kishida, Osamu. AU - Fujimoto, Takashi. AU - Yamada, Akira. AU - Tsukamoto, Yoshifumi. AU - Yamamoto, Shunsuke. AU - Kamada, Yoshihiro. AU - Yoshida, Yuichi. AU - Kiso, Shinichi. AU - Tsutsui, Shusaku. AU - Kihara, Shinji. AU - Hayashi, Norio. AU - Matsuzawa, Yuji. PY - 2011/12/1. Y1 - 2011/12/1. N2 - Obesity is a risk factor for gastro-esophageal reflux disease (GERD). It is generally considered that intra-abdominal pressure in obese subjects is involved in the pathogenesis of GERD through acid exposure to the esophagus. Recently, visceral fat has been recognized as an endocrine organ that secretes various adipocytokines including adiponectin. The aim of this study was to elucidate the relation between ...
The present study demonstrates that PPARγ-activating ARBs induce adiponectin protein expression at a post-transcriptional level, independently of their AT1R-blocking properties. In addition, AT2R activation resulted in adiponectin upregulation. The PPARγ-activating ARB irbesartan improved parameters of insulin sensitivity in obese Zucker rats, which was associated with the prevention of adiponectin serum depletion.. We and others could recently demonstrate that a subset of ARBs including irbesartan has the potential to activate the insulin-sensitizing nuclear hormone receptor PPARγ, completely independent from their AT1R blocking properties.8,10 PPARγ activation has been shown to stimulate adiponectin expression in adipocytes and to upregulate adiponectin plasma levels in animals and humans.6,11 In the present study, pharmacological antagonism of PPARγ completely blocked irbesartan-induced adiponectin expression in vitro. In addition, adiponectin expression in adipocytes and fat tissue was ...
Adiponectin (Ad) is an abundant protein hormone regulatory of numerous metabolic processes, anti-inflammatory, vascular protective, and anti-ischemic properties. Since its 1995 discovery, Ad has garnered considerable attention for its role in diabetic and cardiovascular pathology. Clinical observations have demonstrated the association of hypoadiponectinemia in patients with obesity, cardiovascular disease, and insulin resistance. There is growing evidence supporting Ad can act as a novel risk factor for cardiovascular and cerebrovascular injury. This 5 years follow-up study will focus on serum adiponectin concentration, activity and isoforms in Chinese population and its correlation to cardiovascular and cerebrovascular diseases ...
Adiponectin is the most abundant plasma adipokine, and is well known for its role in energy homeostasis and cardiac protection. In humans with dilated cardiomyopathy, myocardial adiponectin protein expression is reduced compared to normal hearts and has been implicated in the pathology of cardiomyopathy. Serum adiponectin levels are often conflicting, with higher levels associated with poor survival in humans with congestive heart failure (CHF). We evaluated adiponectin serum concentrations and myocardial protein expression in dogs with naturally occurring myxomatous mitral valve disease and CHF. We compared the findings to active and hibernating brown bears as bears are adapted to endure an extreme period of low cardiac output during their annual hibernation. Bears exhibited largely the active high-molecular weight (HMW) versus the low-molecular weight isoforms of myocardial adiponectin (HMW:LMW = 6.3) during both the active period and hibernation, while healthy dogs exhibited a more balanced mix of
Introduction: Adiponectin is anti-inflammatory and anti-tumor cytokine secreted exclusively from adipocytes. Thereis a growing evidence of association between adiponectin gene polymorphism and development of pancreatic cancer.The current study aimed at evaluation of the possible association between selected adiponectin gene polymorphism andthe risk of pancreatic cancer. Methods: Prospective case-control study included 77 patients (29 women and 48 men)with biopsy-proven pancreatic adenocarcinoma and 97 healthy control. Blood samples from all included participantswere genotyped for 3 single nucleotide polymorphism (SNPs) of adiponectin genes (rs1501299C|A, rs266729C|G andrs2241766G|T) by PCR. Clinical, biochemical, and radiological data analyzed. Results: We demonstrated a significantassociation between the three studied SNPs (rs1501299, rs266729, and rs2241766) and increased risk of pancreaticadenocarcinoma (p|0.001). Furthermore, in clinical correlation analysis, Patients with rs2241766 polymorphismhave
TY - JOUR. T1 - Systemic fate of the adipocyte-derived factor adiponectin. AU - Halberg, Nils. AU - Schraw, Todd D.. AU - Wang, Zhao V.. AU - Kim, Ja Young. AU - Yi, James. AU - Hamilton, Mark P.. AU - Luby-Phelps, Kate. AU - Scherer, Philipp E.. PY - 2009/9. Y1 - 2009/9. N2 - OBJECTIVE - The adipocyte-derived secretory protein adiponectin has been widely studied and shown to have potent insulin-sensitizing, antiapoptotic, and anti-inflammatory properties. While its biosynthesis is well understood, its fate, once in circulation, is less well established. RESEARCH DESIGN AND METHODS - Here, we examine the half-life of adiponectin in circulation by tracking fluorescently labeled recombinant adiponectin in the circulation, following it to its final destination in the hepatocyte. RESULTS - Despite its abundant presence in plasma, adiponectin is cleared rapidly with a half-life of ∼75 min. A more bioactive version carrying a mutation at cysteine 39 is cleared within minutes. Even though ...
Studies have shown that single-nucleotide polymorphisms (SNPs) on the ADIPOQ gene have been linked with obesity and with adiponectin levels in various populations. Here, we aimed to investigate the association of ADIPOQ rs17366568 and rs3774261 SNPs with obesity and with adiponectin levels in Malaysian Malays. Obesity parameters and adiponectin levels were measured in 574 subjects. Genotyping was performed using real-time polymerase chain reaction and Sequenom MassARRAY. A significant genotypic association was observed between ADIPOQ rs17366568 and obesity. The frequencies of AG and AA genotypes were significantly higher in the obese group (11%) than in the non-obese group (5%) (P=0.024). The odds of A alleles occurring among the obese group were twice those among the non-obese group (odds ratio 2.15; 95% confidence interval 1.13-4.09). However, no significant association was found between allelic frequencies of ADIPOQ rs17366568 and obesity after Bonferroni correction (P>0.025) or between ...
BACKGROUND: Insulin resistance is the major pathogenesis underlying type 2 diabetes mellitus (T2DM) and these patients have doubled risk of Alzheimers disease (AD). Increasing evidence suggests that insulin resistance plays an important role in AD pathogenesis, possibly due to abnormal GSK3β activation, causing intra- and extracellular amyloid-beta (Aβ) accumulation. Adiponectin (APN) is an adipokine with insulin-sensitizing and anti-inflammatory effects. Reduced circulatory APN level is associated with insulin resistance and T2DM. The role of APN in AD has not been elucidated. In this study, we aim to examine if adiponectin deficiency would lead to cerebral insulin resistance, cognitive decline and Alzheimers-like pathology in mice. METHODS: To study the role of adiponectin in cognitive functions, we employed adiponectin-knockout (APN-KO) mice and demonstrated chronic APN deficiency in their CNS. Behavioral tests were performed to study the cognitions of male APN-KO mice. Brains and tissue ...
Purpose : To validate earlier found physiologic response patterns explaining retinopathy of prematurity (ROP) development in infants born very preterm. Generally adiponectin production is up-regulated by weight loss and down regulated by weight gain, oxidative stress as well as pro-inflammatory cytokines. Disturbed homeostasis, impaired growth and inflammation are factors closely related to ROP development. This study assessed the longitudinal postnatal development of serum adiponectin levels and ROP development in a new cohort of very preterm infants. Methods : A study was performed in 90 infants with gestational age (GA) , 28 weeks with a mean (SD) gestational age at birth of 25.2 (1.4) weeks and mean (SD) birth weight of 882 (220) g. Cord blood samples and thereafter venous blood samples were obtained at postnatal day 1, 7, 14, 28 days and at postmenstrual age 32, 36 and 40 weeks. Serum adiponectin levels were assayed using a human adiponectin ELISA kit (E091M, Mediagnost, Germany). The ...
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AIMS/HYPOTHESIS: Pregnancy, a state of insulin resistance, is associated with elevated levels of cytokines and profound alterations in metabolism. Serum adiponectin, an adipokine with anti-inflammatory and insulin-sensitising properties, has been shown to be lower in patients with gestational diabetes mellitus, a state of greater insulin resistance than normal pregnancies. Hypothesising that the human placenta is a source of adiponectin, we investigated its expression and secretion, and the regulation by cytokines of adiponectin and its receptors. METHODS: Real-time RT-PCR, radioimmunoassay, Western blotting, radioligand binding and immunofluorescent analyses were applied to demonstrate the expression, secretion and functionality of placental adiponectin. RESULTS: Adiponectin gene expression and protein were found in the human term placenta, with expression primarily in the syncytiotrophoblast. RIA of conditioned media from explant experiments revealed that the placenta can secrete adiponectin in vitro.
On the basis of the above-reported properties unraveled by basic science studies, it would be conceivable to hypothesize that adiponectin exerts beneficial effects on metabolic and cardiovascular traits in human beings. In fact, in pioneering cross-sectional studies carried out in Pima Indians, circulating adiponectin levels correlated positively with both skeletal muscle (21) and liver (22) insulin sensitivity. In addition, in this same population, adiponectin was negatively correlated with inflammatory markers (23). Along the same line is the observation that insulin-sensitizing agents increase adiponectin concentrations in humans (24). In addition, a prospective study has also shown that low plasma adiponectin concentration predicts the deterioration of insulin sensitivity over time (25).. Unfortunately, the observational design of all such studies could not address whether the reported associations were due to a positive effect of adiponectin on insulin sensitivity. In this regard, it must ...
The hormone adiponectin is secreted from fat cells. Overweight and obese people are known to have less adiponectin secreted and they are definitely at higher risk for suffering from cancers. The mechanism linking hormone existence to overall health is the following: high adiponectin levels in blood are able to suppress blood vessels inflammation, this leads to increased metabolism.. Therefore, higher adiponectin levels decrease the risk of obesity, diabetes, heart disease, breast cancer and now it is also linked to colorectal cancer. It is clear that hormone adiponectin makes people healthier, but how exactly the hormone is being secreted from fat cells is yet unclear.. According to American Cancer Society statistics, colorectal cancer affects 1.2 million and kills 630000 people worldwide each year. This year is estimated to have 149000 newly diagnosed and 50000 cases in US. About 1/3 of cases are associated with family history, other factors causing the disease are believed to be diet reach in ...
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Adiponectin is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid oxidation.[7] Adiponectin is secreted from adipose tissue (and also from the placenta in pregnancy[8]) into the bloodstream and is very abundant in plasma relative to many hormones. Many studies have found adiponectin to be inversely correlated with body mass index in patient populations.[9] However, a meta analysis was not able to confirm this association in healthy adults.[10] Circulating adiponectin concentrations increase during caloric restriction in animals and humans, such as in patients with anorexia nervosa. This observation is surprising, given that adiponectin is produced by adipose tissue. However, a recent study suggests that adipose tissue within bone marrow, which increases during caloric restriction, contributes to elevated circulating adiponectin in this context.[11]. Transgenic mice with increased adiponectin show reduced adipocyte differentiation and ...
ABSTRACT. Background and aims: Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are well-recognized complications of obesity. This study was designed to evaluate the role of the UCP1 -3826 A,G polymorphism, adiponectin levels, leptin/adiponectin ratio (L/A), and main biochemical parameters in 102 unrelated severely obese adults [61 females and 41 males, median body mass index (BMI) = 47.8 kg/m2] with NAFLD, with (MS+) or without MS (MS-) from Southern Italy. Subject and methods: The UCP1 polymorphism was tested by the TaqMan method, main biochemical parameters by routinary methods, adiponectin, and leptin serum levels by enzyme-linked immunosorbent assay. MS was diagnosed according to the American Heart Association criteria, liver steatosis was detected by ultrasound. Results: MS was present in 53% male and 66% female obese patients. Only total cholesterol (p=0.04 males and p=0.002 females) and L/A ratio (p=0.03 males) differed between MS+ and MS- obese patients. At ...
Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 amino acid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells (adipokine). The protein belongs to the soluble defence collagen superfamily; it has a collagen-like domain structurally homologous with collagen VIII and X and complement factor C1q-like globular domain. Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. The human Adiponectin is expressed in E. coli as a recombinant 25.1 kDa sinle, non-glycosylated polypeptide chain containing 231 amino acid residues ...
Results MN and CD4+T cells from RA patients showed a higher proliferative effect when exposed to leptin and adiponectin in comparison with healthy donors. Interesting, the level of proliferation correlated with the DAS28 of patients. Similarly, cells from patients were more sensitive to leptin and adiponectin treatment when evaluating CD25+/CD69+ cell expression and IL-2, TNF secretion, in comparison to healthy donor cells. Comparatively, adiponectin treatment was more effective to induce the expression of CD25, CD69 and IL-6, whereas leptin was a better inductor of IL-2 and TNF-a on the RA patient cells. Comparing this with the clinical activity of patients, we only observed a significant correlation between the DAS28 and the IL-2 induction when exposed to leptin. Preliminary assays showed that leptin was also capable to rescue MN cells from an apoptotic environment by a mechanism related to IL-2 secretion. On the other hand, MN cells from RA patients incubated for several days with leptin ...
PubMed journal article: Association of low adiponectin levels with the metabolic syndrome--the Chennai Urban Rural Epidemiology Study (CURES-4). Download Prime PubMed App to iPhone, iPad, or Android
Problem statement: Adiponectin is an adipocyte secreted hormones, exerts its effects via the specific receptors. AdipoR1 and adipoR2 and plays a pivotal role in lipid and glucose metabolism. Approach: We investigated the effect of increased physical activities on insulin resistance and if this effect is modulated through adiponectin receptor expression. Results: We also assessed the effect of High Fat Diet (HFD) on adipoRs expression. Mice were subjected to 16 weeks of HFD protocol then to 4, 6 and 8 weeks of exercise training. Following the experimental protocol the fasting plasma glucose, insulin and index of Homeostasis Model Assessment of insulin Resistance (HOMA-R) were evaluated. The mRNA expression of adiponectin receptors genes were also analyzed using reverse transcription RT-PCR. The consumption of high fat diet by the mice for 16 weeks resulted in a significant increase in weight associated with insulin resistance and associated with significant decrease in adiponectin receptors R1 and R2
Title: Serum Adiponectin Levels in Patients with Familial Mediterranean Fever. VOLUME: 17 ISSUE: 10. Author(s):Goksal Keskin, Ali Inal and Lale Ozisik. Affiliation:DYBEA Hospital, Head of 4. Internal Medicine Department, Ankara, Turkey.. Keywords:Adiponectin, IL-6, FMF. Abstract: Familial mediterranean fever (FMF) is a systemic disorder characterized by recurrent attacks of fever and polyserositis. In FMF, several pro-inflammatory cytokines, such as IL-6, have been found to be elevated during the attacks. In recent years, it is shown that some proteins originated from adipose tissue play important role in inflammatory process. One of them, adiponectin decreases the expression of adhesion molecules and inhibits the attachment of active macrophages to the endothelial surface, so that it acts antiinflammatory effect. In this study, we analyzed the possible role of serum adiponectin in the pathogenesis of FMF. Thirty five patients with FMF and 13 healthy controls (5 female,8 male; mean age 22.3 ± ...
TY - JOUR. T1 - Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity. AU - Kyriakou, Theodosios. AU - Collins, Laura J.. AU - Spencer-Jones, Nicola J.. AU - Malcolm, Claire. AU - Wang, Xiaoling. AU - Snieder, Harold. AU - Swaminathan, Ramasamyiyer. AU - Burling, Keith A.. AU - Hart, Deborah J.. AU - Spector, Tim D.. AU - ODell, Sandra D.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2008/8. Y1 - 2008/8. N2 - Adiponectin is an insulin sensitiser in muscle and liver, and low serum levels characterise obesity and insulin resistance. Eight tagging single nucleotide polymorphisms (tSNPs) in the ADIPOQ gene and promoter were selected, and association with serum adiponectin was tested, in two independent samples of Caucasian women: the Chingford Study (n = 808, mean age 62.8 ± 5.9 years) and Twins UK (n = 2,718, mean age 47.4 ± 12.6 years). In the Chingford cohort, -11391 G/A, -10066 G/A ...
CONTEXT: Adiponectin is an adipocyte-derived cytokine with insulin-sensitizing and antiinflammatory properties. These dual actions have not previously been examined in the context of human disease. OBJECTIVES: Our objective was to examine the adiponectin axis in type 1 diabetes (T1D). T1D is an autoimmune inflammatory disease resulting from pancreatic β-cell destruction, in which insulin resistance associates with progression to disease. DESIGN, PATIENTS, AND INTERVENTIONS: We measured circulating adiponectin and adiponectin receptor expression on blood-immune cells from 108 matched healthy, T1D, and type 2 diabetic subjects. We tested adiponectin effect on T cell proliferation to islet antigens and antigen-presenting function of monocyte-derived dendritic cells (mDCs). Lastly, we assessed the effect of a 3-week lifestyle intervention program on immune cell adiponectin receptor expression in 18 healthy subjects. RESULTS: Circulating concentrations of adiponectin were not affected by T1D. However,
The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n = 8,531) and sought validation of the lead single nucleotide polymorphisms (SNPs) in 5 additional cohorts (n = 6,202). Five SNPs were genome-wide significant in their relationship with adiponectin (P≤5×10−8). We then tested whether these 5 SNPs were associated with risk of T2D and CHD using a Bonferroni-corrected threshold of P≤0.011 to declare statistical significance for these disease associations. SNPs at the adiponectin-encoding ADIPOQ locus demonstrated the strongest associations with adiponectin levels (P-combined = 9.2×10−19 for lead SNP, rs266717, n = 14,733). A novel variant in the ARL15 (ADP-ribosylation factor-like 15) gene was associated with lower circulating levels of adiponectin (rs4311394-G, P-combined = 2.9×10−8, n = ...
Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene. We created an ADIPOQ allele score that explained approximately 3% of the interindividual variation in adiponectin concentrations. The ADIPOQ allele score was not associated with risk of colorectal cancer in logistic regression analyses (pooled OR per score-unit unit 0.97, 95% CI 0.91, 1.04). Genetically determined twofold ...
Adiponectin, a fat tissue-derived adipokine, exhibits beneficial effects against insulin resistance, cardiovascular disease, inflammatory conditions, and cancer. Circulating adiponectin levels are decreased in obese individuals, and this feature correlates with increased risk of developing several metabolic, immunological and neoplastic diseases. Thus, pharmacological replacement of adiponectin might prove clinically beneficial, especially for the obese patient population. At present, adiponectin-based therapeutics are not available, partly due to yet unclear structure/function relationships of the cytokine and difficulties in converting the full size adiponectin protein into a viable drug. We aimed to generate adiponectin-based short peptide that can mimic adiponectin action and be suitable for preclinical and clinical development as a cancer therapeutic. Using a panel of 66 overlapping 10 amino acid-long peptides covering the entire adiponectin globular domain (residues 105-254), we identified the 149
TY - JOUR. T1 - Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. AU - Iacobellis, Gianluca. AU - Pistilli, Daniela. AU - Gucciardo, Marco. AU - Leonetti, Frida. AU - Miraldi, Fabio. AU - Brancaccio, Gianluca. AU - Gallo, Pietro. AU - Tiziana Di Gioia, Cira Rosaria. PY - 2005/3/21. Y1 - 2005/3/21. N2 - Background: Intra-peritoneal adipose tissue is recognized as a predictor of metabolic syndrome and may contribute to the risk for cardiovascular disease by the production of adipocytokines, including adiponectin. Nevertheless, there is no knowledge on whether other visceral depots of adipose tissue, including the epicardial fat, have any metabolically active role, including production of adiponectin. Aim of the study: We sought to evaluate adiponectin protein expression in epicardial adipose tissue in vivo both in patients with severe coronary artery disease (CAD) and in subjects without CAD. Methods: Twenty-two patients were ...
TY - JOUR. T1 - The association of SNP276G,T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss. AU - Shin, M. J.. AU - Jang, Y.. AU - Koh, S. J.. AU - Chae, J. S.. AU - Kim, O. Y.. AU - Lee, J. E.. AU - Ordovas, J. M.. AU - Lee, J. H.. PY - 2006/12/21. Y1 - 2006/12/21. N2 - Objective:The purpose of this study was to determine whether common single nucleotide polymorphisms (SNPs) at the adiponectin (ADIPOQ) locus influence changes in circulating adiponectin and the features of insulin resistance in response to a weight loss intervention.Subjects:In total, 294 nondiabetic/overweight-obese Koreans participated in a clinical intervention study lasting 12 weeks involving a caloric reduction of -300kcal/day.Methods: Plasma adiponectin, blood lipids, glucose and insulin concentrations were measured at baseline and after weight loss. Insulin resistance was estimated by homeostasis model assessment insulin resistance (HOMA-IR) derived from fasting ...
The purpose of this study was to investigate the mechanism behind adipose tissue wound healing (ATWH). The preadipocyte cell line 3T3-L1 was cultured and expression of adiponectin receptors (AdipoR1/2) was detected by immunohistochemistry and reverse transcription polymerase chain reaction. The concentration of adiponectin secreted at different cell densities was measured by enzyme-linked immunosorbent assay, while preadipocyte proliferation and migration were determined in vitro by MTT and wound closure assays. AdipoR1/2 were found to be expressed in 3T3-L1 preadipocytes. There were no statistically significant differences in the concentrations of adiponectin secreted by cell solutions of different densities (P | 0.05). In addition, adiponectin was seen to promote the growth and migration of preadipocytes. In conclusion, adiponectin may regulate ATWH by promoting preadipocyte proliferation and migration, and its systemic and/or local application is proposed as a promising therapeutic approach for the
ABSTRACT. Objectives: to evaluate and compare serum adiponectin levels in different phenotypes of polycystic ovary syndrome (PCOS) and to investigate their correlation with endocrine and metabolic parameters. Material and methods: we studied 5 groups of patients: A (n = 20): H (hyperandrogenism) + O (oligoanovulation) + P (polycystic ovary) [classic phenotype]; B (n = 17): H + O [classic phenotype but normal ovaries]; C (n = 15): H + P [Ovulatory phenotype]; D (n = 17): O + P [Normoandrogenic phenotype]; and E (n = 16) control group. Body mass index, waist circumference, waist/hip ratio, blood pressure and hirsutism were evaluated. Serum concentrations of adiponectin, insulin, Creactive protein, SHBG, androgens and lipids were measured. Oral glucose tolerance test was performed. Results: there were no differences between the groups in terms of age and BMI. Total cholesterol, LDL-C and triglyceride levels were higher in phenotype A than in C (P < 0.05); HDL-C was slightly lower in phenotype D ...
Oxidative stress plays a critical role in the vascular complications of type 2 diabetes. We examined the effect of type 2 diabetes on NADPH oxidase in human vessels and explored the mechanisms of this interaction. Segments of internal mammary arteries (IMAs) with their perivascular adipose tissue (PVAT) and thoracic adipose tissue were obtained from 386 patients undergoing coronary bypass surgery (127 with type 2 diabetes). Type 2 diabetes was strongly correlated with hypoadiponectinemia and increased vascular NADPH oxidase-derived superoxide anions (O2˙(-)). The genetic variability of the ADIPOQ gene and circulating adiponectin (but not interleukin-6) were independent predictors of NADPH oxidase-derived O2˙(-). However, adiponectin expression in PVAT was positively correlated with vascular NADPH oxidase-derived O2˙(-). Recombinant adiponectin directly inhibited NADPH oxidase in human arteries ex vivo by preventing the activation/membrane translocation of Rac1 and downregulating p22(phox) through a
Background and aims: Previous studies have documented environmental risk factors for the progression of carotid intima-media thickness (IMT); however, few have examined genetic risk factors for the progression of carotid IMT and none has specifically examined subjects with type 2 diabetes. This study examined the association between single nucleotide polymorphisms in the adiponectin gene and the progression of carotid IMT in patients with type 2 diabetes.. Materials and methods: We performed common carotid ultrasonography at baseline and 33 39 months later in 324 consecutive subjects with type 2 diabetes. The genotypes of the adiponectin gene were determined using a single base primer extension method.. Results: The A allele of −11426A/G (P,0.05), G allele of −10066C/G (P=0.001), A allele of −8564G/A (P,0.01), A allele of −450A/G (P,0.05), and G allele of 276G/T (P,0.01) were associated with progressive carotid IMT. In the haplotype analysis, the AC/AC haplotype combination in block 1, ...
As a part of the three-column structure of vertebrae, facet joints play a key role in maintaining the stability of spinal motion, particularly in the lumbar area [24]. Therefore, most doctors are concerned with the biomechanical and mechanical factors affecting lumbar facet joints. However, the pathogenesis of FJOA has not been fully elucidated. Accordingly, in this study, we evaluated the expression of adiponectin in lumbar facet joints. Our results showed that adiponectin expression was significantly downregulated with increasing degeneration of the lumbar facet joint.. Adiponectin is an adipocyte factor specifically secreted from fat cells. Adiponectin is composed of 244 amino acids; the N-terminus contains one secretory signal sequence, and the C-terminus contains a spherical egg white function threshold. Previous studies have shown that adiponectin is involved in glucose homeostasis, insulin sensitivity, and vascular inflammatory diseases [25, 26]. Adiponectin in human peripheral blood ...
TY - JOUR. T1 - Adiponectin and leptin in overweight/obese and lean women with polycystic ovary syndrome. AU - Chen, Chin I.. AU - Hsu, Ming-I. AU - Lin, Shyh-Hsiang. AU - Chang, Yuan Chin Ivan. AU - Hsu, Chun-Sen. AU - Tzeng, Chii-Ruey. PY - 2015/4/1. Y1 - 2015/4/1. N2 - Aim: The objective of this study was to evaluate the adiponectin and leptin levels in overweight/obese and lean women with polycystic ovary syndrome (PCOS). Design: This was a retrospective study. Patients: Of the 422 studied patients, 224 women with PCOS and 198 women without PCOS were evaluated. Main outcome measure(s): Insulin resistance and the metabolic components were assessed. The adiponectin and leptin levels were also evaluated. Results: Adiponectin was negatively correlated with insulin resistance, body mass index (BMI), and total testosterone, triglyceride, and low-density lipoprotein (LDL) levels; conversely, leptin reversed the aforementioned reaction and was negatively correlated with adiponectin levels. The ...
The present study determined the dynamic change of adiponectin (APN, a cardioprotective adipokine), its receptor expression, and their impact upon myocardial ischemia/reperfusion (MI/R) injury during type 1 diabetes mellitus (T1DM) progression, and involved underlying mechanisms. Diabetic state was induced in mice via multiple intraperitoneal injections of low-dose streptozotocin. The dynamic change of plasma APN concentration and cardiac APN receptor-1 and -2 (AdipoR1/2) expression were assessed immediately after diabetes onset (0 wk) and 1, 3, 5, and 7 wk thereafter. Indicators of MI/R injury (infarct size, apoptosis, and LDH release) were determined at 0, 1, and 7 wk of DM duration. The effect of APN on MI/R injury was determined in mice subjected to different diabetic durations. Plasma APN levels (total and HMW form) increased, whereas cardiac AdipoR1 expression decreased early after T1DM onset. With T1DM progression, APN levels were reduced and cardiac AdipoR1 expression increased. MI/R injury was
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Aim Increased frequency of cardiovascular disease and its possible relations with insulin resistance have been reported in patients with inflammatory diseases. The aim of our study was to investigate insulin resistance and serum adiponectin levels as cardiovascular risk markers in patients with Behçets disease.. Method Study population consisted of 40 patients with Behçets disease (BD) and a control group composed of age, gender, body mass index-matched 46 healthy individuals. All patients were examined for signs of Behçets disease. Body mass index, waist and hip circumference were measured. Insulin resistance was evaluated using the homeostasis model assessment-insulin resistance method. Erythrocyte sedimentation rate (ESR), lipid profile, high sensitive CRP (hsCRP), adiponectin, TNF-α, IL-6 and IL-8 levels were measured.. Results Erythrocyte sedimentation rate, serum hsCRP and IL-6 levels were significantly higher in patients with BD than those in the controls (P = 0.001, P = 0.001, P = ...
Adiponectin (ADN) is an adipokine derived from adipocytes. It binds to adiponectin receptor 1 and 2 (AdipoR1 and R2) to exert its function in regulating whole-body energy homeostasis and inflammatory responses. However, the role of ADN-AdipoR1 signaling in intestinal inflammation is controversial, and its role in the regulation of neutrophils is still unclear. Our goal was to clarify the role of AdipoR1 signaling in colitis and the effects on neutrophils. We generated porcine AdipoR1 transgenic mice (pAdipoR1 mice) and induced murine colitis using dextran sulfate sodium (DSS) to study the potential role of AdipoR1 in inflammatory bowel disease. We also treated a THP-1 macrophage and a HT-29 colon epithelial cell line with ADN recombinant protein to study the effects of ADN on inflammation. After inducing murine colitis, pAdipoR1 mice developed more severe symptoms than wild-type (WT) mice. Treatment with ADN increased the expression of pro-inflammatory factors in THP-1 and HT-29 cells. Moreover, we also
After screening all of 280 patients under regular HD in Faghihi Hospital Hemodialysis Center, 80 stable patients in the age range of 18-80 years old were found to be eligible for enrollment and give their informed consent to participate in this trial.The Ethics Committee of Shiraz University of Medical Sciences reviewed and approved the protocol of this study.These patients are randomly assigned in a 1:1 ratio into 2 groups of selenium(200µg) or placebo and followed for 12 weeks.Before the onset of the treatment and after the end of the treatment phase of the study, 10cc blood samples were taken from each patient. The blood was taken from the patients arm used for hemodialysis cannulae just before the beginning of the HD session. The serum was separated by centrifugation at 3000 g/min for 5 min and stored at -70°C. Serum levels of adiponectin,high sensitive C-reactive protein (HSCRP), ferritin, transferrin, homocysteine, calcium, phosphate, albumin, blood urea nitrogen (BUN), and creatinine ...
The adiponectin receptor 1 for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (Tanabe et al. 2015; Yamauchi et al. 2003. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. The 3-d structure revealed ceramidase activity for both ADIPOR1 and ADIPOR2; however, the two structures are substantially different (Vasiliauskaité-Brooks et al. 2017). It may function with adiponectin to stimulate cholesterol efflux via ABCA1 (Hafiane et al. 2019 ...
Farrell Cahill, a PhD student under the supervision of Dr. Guang Sun in the Faculty of Medicine, has discovered evidence that may shed new light on how the hormone adiponectin may aid in the attenuation of insulin resistance development during weight gain. The study, titled Short-term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status, was published in the peer-reviewed journal PLOS ONE on Aug. 30.. Insulin resistance comprises about 90 per cent of all diabetic cases and has become an ever increasing health-care challenge with a significant fiscal burden, said Mr. Cahill. This is especially relevant to Newfoundland and Labrador considering it has one the highest rates of diabetes and obesity in Canada. Mr. Cahill explained that the accumulation of white adipose tissue (WAT) is the product of a chronic positive energy balance in an obesogenic environment.. Numerous disorders such as insulin resistance have shown a strong association with the accumulation of fat mass. ...
The adiponectin receptor 1 for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (Tanabe et al. 2015; Yamauchi et al. 2003. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. The 3-d structure revealed ceramidase activity for both ADIPOR1 and ADIPOR2; however, the two structures are substantially different (Vasiliauskaité-Brooks et al. 2017 ...
Serum from pregnant women with gestational diabetes mellitus (GDM) increased the expression of fatty acid-binding protein 4 (FABP4) mRNA and decreased the expression of adiponectin mRNA in primary subcutaneous human pre-adipocytes. After primary human pre-adipocytes were cultured using serum from pregnant women with GDM and normal pregnant women for 24 hours, real-time polymerase chain reaction and Western blot was performed. (A) Expression of FABP4 mRNA in adipocytes cultured in serum from pregnant women with GDM was higher than that from the normal group. (B) Expression of adiponectin mRNA in adipocytes cultured in serum from mothers with GDM was lower than that from the normal group. (C) FABP4 and adiponectin protein level in adipocyte were determined by Western blot (representative blots are shown). (D) Band densities in the Western blot were quantified using ImageJ software. Trends toward increased FABP4 protein expression and decreased adiponectin protein expression in GDM group were ...
Adiponectin concentrations were protective against DM2 [24]. In humans plasma adiponectin was found to be associated with skeletal muscle insulin receptor tyrosine phosphorylation. In pregnant women a decrease of adiponectin was shown with increasing insulin resistance in the third trimester and a further decrease in women with IGT or GDM compared to pregnant women with NT even after adjustment for varying degrees of adiposity [25]. In parallel decreased adiponectin mRNA levels were found in abdominal subcutaneous adipose tissue biopsies from women with GDM. Under normal conditions, during early pregnancy, basal glucose and insulin concentrations do not differ from nongravid values [9], and hepatic gluconeogenesis is unchanged [10]. However, during late pregnancy the mother tends to develop hypoglycemia, which is especially evident during fasting. Indirect studies in women [11] and direct experiments in rats [12] have shown that the rate of gluconeogenesis is enhanced during pregnancy under ...
Journal of Immunology. 178(6):3511-3520. PubMed , PDF , ABSTRACT. The hemopoietic microenvironment consists of a diverse repertoire of cells capable of providing signals that influence hemopoietic stem cell function. Although the role of osteoblasts and vascular endothelial cells has recently been characterized, the function of the most abundant cell type in the bone marrow, the adipocyte, is less defined. Given the emergence of a growing number of adipokines, it is possible that these factors may also play a role in regulating hematopoiesis. Here, we investigated the role of adiponectin, a secreted molecule derived from adipocytes, in hemopoietic stem cell (HSC) function. We show that adiponectin is expressed by components of the HSC niche and its receptors AdipoR1 and AdipoR2 are expressed by HSCs. At a functional level, adiponectin influences HSCs by increasing their proliferation, while retaining the cells in a functionally immature state as determined by in vitro and in vivo assays. We ...
Coronary Heart Disease (CHD) is one of the leading causes of death in the world with a projected global 82 million DALYs by 2020. Genetic and environmental factors contribute to CHD development. Here, the authors investigate the association between CHD risk and three Single Nucleotide Polymorphisms (SNPs) in the AdipoQ gene (rs3774261, rs1063537 and rs2082940); and the interaction of this association with environmental factors, in Northeast Han Chinese population. Using a case-control study design, 1514 participants (754 cases and 760 controls) were investigated. Three variants in the AdipoQ gene (rs3774261, rs1063537 and rs2082940) were selected and genotyped. The online SNPstats program and SPSS 21.0 software were used for data analyses. The authors found that the rs3774261G allele is associated with the risk of CHD but that the rs2082940T allele protects against CHD. No significant association was found between rs1063537 and CHD risk. The study also found significant interactions between triglyceride
Binding of adiponectin to ADIPOR1 results in activation of an AMP-dependent kinase (AMPK) signaling pathway that regulates fatty acid oxidation and insulin sensitivity. ADIPOR1 is also known as progestin and adipoQ receptor family member I (PAQR1), CGI45, ACDCR1, and TESBP1A.. Binding of adiponectin to ADIPOR2 mediates increased AMP-activated protein kinase (AMPK) activity, peroxisome proliferator-activated receptor-alpha (PPAR-alpha) ligand activity, fatty acid oxidation, and glucose uptake. ADIPOR2 is also known as progestin and adipoQ receptor family member II (PAQR2), and ACDCR2. ...
Binding of adiponectin to ADIPOR1 results in activation of an AMP-dependent kinase (AMPK) signaling pathway that regulates fatty acid oxidation and insulin sensitivity. ADIPOR1 is also known as progestin and adipoQ receptor family member I (PAQR1), CGI45, ACDCR1, and TESBP1A.. Binding of adiponectin to ADIPOR2 mediates increased AMP-activated protein kinase (AMPK) activity, peroxisome proliferator-activated receptor-alpha (PPAR-alpha) ligand activity, fatty acid oxidation, and glucose uptake. ADIPOR2 is also known as progestin and adipoQ receptor family member II (PAQR2), and ACDCR2. ...
Decaffeinated GTE was not associated with reductions in body weight, BMI, or WC and did not alter energy intake or mean hormone concentrations in healthy postmenopausal women over 12 mo. GTE decreased fasting insulin concentrations in those with elevated baseline fasting concentrations. The high-act …
TY - JOUR. T1 - Adiponectin and negative mood in healthy premenopausal and postmenopausal women. AU - Adam, Tanja. AU - Schamarek, Imke. AU - Springer, Elizabeth A.. AU - Havel, Peter J. AU - Epel, Elissa E.. PY - 2010/11. Y1 - 2010/11. N2 - Negative mood and stress are associated with cardiovascular and metabolic disease. There are likely many physiological mechanisms underlying the poor health outcomes. The relationship of psychological states (negative mood, life stress, and stress-responsive hormones) and adiponectin, an adipokine that promotes insulin sensitivity, was investigated in two separate studies. The two groups of participants included 52 healthy, premenopausal women, and 63 postmenopausal women with a range of stress levels. The relationship between adiponectin and psychological state (perceived stress and negative mood) was examined cross-sectionally in both groups of participants, but also prospectively (1 year later) in the group of postmenopausal women. In premenopausal women, ...
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In the present study, HMW-adn and HMW-adn/T-adn were negatively correlated with anthropometric variables (BMI, %BF, WC, and WHtR). Furthermore, only WHtR was significantly or marginally significantly correlated with HMW-adn or HMW-adn/T-adn regardless of sex and physique. To the best of our knowledge, this study is the first study regarding the relationship between HMW-adn or HMW-adn/T-adn and anthropometric variables among over 1600 population-based elementary schoolchildren in Japan, where blood collection and the measurement of %BF and WC are not commonly performed in the annual health examination at elementary schools.. In this study, statistically significant differences between boys and girls were found in most anthropometric variables (Table 1). For example, %BF among boys was higher than that among girls in the present study, which was consistent with other study results conducted among Japanese children 9-10 years of age [15, 16]. A previous study showed that sexual differences in body ...
Almost half of adults over age 30 in the United States have periodontal disease. In most cases, a few visits to the dentist take care of the problem. In patients with Type 2 diabetes, however, gum disease is extremely difficult to treat, because systemic inflammation can cause it to spread unchecked, leading to tooth loss and massive erosion of jawbone.. Diabetic patients have a much higher chance of developing periodontitis than the rest of the population, and when they do get it, its very difficult to handle, said Jake Jinkun Chen, a professor and molecular biologist at Tufts School of Dental Medicine whose lab studies diabetes-associated periodontal disease. The lab is exploring a promising new way to treat resistant cases with an experimental drug that mimics the behavior of the hormone adiponectin in the body; adiponectin helps regulate glucose levels as well as the breakdown of fatty acids.. Produced by fat cells, adiponectin can signal the body to generate more bone in areas where it ...
Background: Obesity is a significant risk factor for the development of endometrial cancer (EC). Epidemiological studies indicate that adiponectin is significantly decreased in the obese woman and in women with EC. Adiponectin is an insulin-sensitizing, anti-inflammatory cytokine produced in adipose that has pleiotropic effects on numerous physiologic processes and peripheral tissues. In normal metabolic tissues, adiponectin acts through the adiponectin receptor 1 (AdipoR1) to activate the AMPK pathway. Adiponectin stimulates AMPK by promoting the formation of AdipoR1-APPL1 complexes. APPL2 antagonizes AdipoR1 signaling by blocking the formation of these complexes. AdipoR1-APPL1 complexes activate AMPK signaling which can negatively regulate the mTOR pathway, an important contributor to the development of endometrial complex atypical hyperplasia (CAH) and EC, to inhibit protein synthesis and cell growth during times of cellular starvation. The goal of these studies was to assess adiponectin ...
Immune escape is a fundamental trait of cancer. Dendritic cells (DC) that interact with T cells represent a crucial site for the development of tolerance to tumor antigens, but there remains incomplete knowledge about how DC-tolerizing signals evolve during tumorigenesis. In this study, we show that DCs isolated from patients with metastatic or locally advanced breast cancer express high levels of the adiponectin receptors AdipoR1 and AdipoR2, which are sufficient to blunt antitumor immunity. Mechanistic investigations of ligand-receptor interactions on DCs revealed novel signaling pathways for each receptor. AdipoR1 stimulated IL10 production by activating the AMPK and MAPKp38 pathways, whereas AdipoR2 modified inflammatory processes by activating the COX-2 and PPARγ pathways. Stimulation of these pathways was sufficient to block activation of NF-κB in DC, thereby attenuating their ability to stimulate antigen-specific T-cell responses. Together, our findings reveal novel insights into how DC
Adiponectin is a fat tissue-derived adipokine with beneficial effects against diabetes, cardiovascular diseases, and cancer. Accordingly, adiponectin-mimetic molecules possess significant pharmacological potential. Oligomeric states of adiponectin appear to determine its biological activity. We identified a highly conserved, 13-residue segment (ADP-1) from adiponectins collagen domain which comprises GXXG motifs and has one asparagine and two histidine residues that assist in oligomeric protein assembly. We therefore hypothesized that ADP-1 promotes oligomeric assembly and thereby mediates potential metabolic effects. We observed here that ADP-1 is stable in human serum and oligomerizes in aqueous environments. We also found that ADP-1 activates AMP-activated protein kinase (AMPK) in an adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1)-dependent pathway and stimulates glucose uptake in rat skeletal muscle cells (L-6 myotubes). ADP-1-induced glucose ...
There are few reports on the effects of ethnicity or gender in the association between adipocytokines and insulin resistance in children of different ages. This study assessed associations between serum concentrations of adiponectin/resistin and parameters of insulin resistance in children from 4 different countries. A total of 2,290 children were analyzed in this study; each was from one of 4 different countries (Japan, Thailand, Italy and USA), and grouped according to age (8-11 years old in Group 1 and 12-15 years old in Group 2). Adioponectin was higher in female than in male children, and in Group 1 than in Group 2. Generally, adiponectin was lower in Asian as compared to Italian and American children. These tendencies remained even after adjustment for body mass index (BMI) or waist circumstance (WC). Among older children (Group 2), resistin was higher in female than in male children. Significant correlations by non-parametric univariate correlation coefficients and Spearmans rank correlation
BACKGROUND AND AIMS While elevated serum adiponectin and resistin levels have been singly associated with all-cause mortality in patients with type 2 diabetes (T2D), their combined effect has never been studied. We investigated such joint effect in patients with T2D and its possible modulation by several demographic and clinical conditions, known to affect per se mortality rate. METHODS Patients with T2D from the Gargano Mortality Study (GMS; N = 895, follow-up = 10.5 ± 3.7 years; 290 events) and the Foggia Mortality Study (FMS; N = 519, follow-up = 7.1 ± 2.5 years; 140 events) were examined. RESULTS As singly considered, adiponectin and resistin were independently associated with mortality rate in GMS and FMS (p | 0.0001 for both). The two studies were then pooled, for investigating the nature of the joint effect of the two adipokines. In such sample, both adipokines were associated with death, independent of each other and of several additional covariates (p = 0.01-4.58 × 10(-12)). Of note, no
The microtiter plate provided in this kit has been pre-coated with an antibody specific to Adiponectin Receptor 1 (ADIPOR1). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to ...
redOrbit Staff & Wire Reports - Your Universe Online. The use of fish oil supplements has been linked to a moderate increase in production of a hormone that has in turn been associated with a decreased risk of some forms of diabetes and heart disease, researchers from the Harvard School of Public Health (HSPH) report in a new study.. The supplements, which are also known as omega-3 fatty acid capsules, increase levels of the hormone adiponectin in a patient´s bloodstream. According to the researchers, adiponectin has a key role in several metabolic processes, including glucose regulation and modulation of inflammation; and long-term human studies have found a correlation between higher levels of the hormone and a reduced risk of Type 2 diabetes and coronary heart disease.. While prior animal studies found fish oil increased circulating adiponectin, whether similar effects apply in humans is not established, lead author Jason Wu, a research associate in the university´s epidemiology ...
In a randomised placebo-controlled study of thirty overweight/obese women with PCOS (body mass index>25 kg/m(2), mean age 29.1+/- 1.2 (S.E.M.) years) randomly allocated to either rosiglitazone (Avandia, 4 mg twice a day) or placebo treatment and to assess of plasma levels of adiponectin, resistin and ghrelin and their correlation to serum levels of insulin, C-peptide and steroid hormones, and insulin sensitivity (euglycaemic hyperinsulinaemic clamp), posted in PubMed, found that Rosiglitazone had beneficial effects on serum levels of adiponectin and resistin, suggesting that these adipocytokines may contribute to the improvement in insulin sensitivity observed during the treatment ...
ADSL Adiponectin deficiency; 612556; ADIPOQ Adrenal cortical carcinoma; 202300; TP53 Adrenal hyperplasia, congenital, due to 11 ...
... small-molecule agonist of the adiponectin receptors to be identified. Adiponectin receptor agonists such as AdipoRon have ... Dysregulation of adiponectin expression has also been implicated in the pathology of mood disorders, anxiety disorders, eating ... As such, adiponectin receptor agonists are a highly interesting therapeutic target for a variety of different conditions. ... In addition, adiponectin has recently been elucidated to mediate the antidepressant, anxiolytic, and neurogenic effects of ...
Regulating cytokines like leptin and adiponectin. OXT decreased fat mass, resulting in reduction in leptin level. Oxytocin may ... and late-onset obesity with increases in abdominal fats and fasting plasma triglycerides The balance of leptin and adiponectin ... cross-sectional evaluation of baseline circulating levels of the novel hormone Irisin and the established adipokine adiponectin ...
... has been identified as a novel protein involved in the regulation of adiponectin trafficking and release from the ... RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte ... potentially contributing to lower circulating levels of adiponectin observed in obese populations. RAB11FIP1 has been shown to ... "The Rab11 Effector Protein FIP1 Regulates Adiponectin". PLOS ONE. 8 (9): e74687. doi:10.1371/journal.pone.0074687. PMC 3770573 ...
A negative regulator of adiponectin gene expression". J. Biol. Chem. 281 (42): 31245-53. doi:10.1074/jbc.M605132200. PMID ...
October 2010). "Adiponectin lowers glucose production by increasing SOGA". Am. J. Pathol. 177 (4): 1936-45. doi:10.2353/ajpath. ...
... and they have higher circulating adiponectin, suggesting a link between longevity and adiponectin production. In addition, high ... Brown adipose tissue activation through cold exposure increases adiponectin levels, just two hours of cold exposure resulted in ... Centenarians (both men and women) and their offspring have been found to have genetics that boost adiponectin, ... Imbeault, Pascal; Dépault, Isabelle; Haman, François (2009-04-01). "Cold exposure increases adiponectin levels in men". ...
Adiponectin: is a type of protein secreted by adipose cells that improves insulin sensitivity and possesses antiatherogenic ... Lower levels of s-adiponectin are associated with ischemic stroke. Aging: the prevalence of silent stroke rises with increasing ... Bang, OY; Saver, JL; Ovbiagele, B; Choi, YJ; Yoon, SR; Lee, KH (2007). "Adiponectin levels in patients with intracranial ...
Stumvoll M, Häring H (November 2002). "Resistin and adiponectin--of mice and men". Obes. Res. 10 (11): 1197-9. doi:10.1038/oby. ... Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ (October 2003). "Plasma resistin, adiponectin and leptin levels ... Milan G, Granzotto M, Scarda A, Calcagno A, Pagano C, Federspil G, Vettor R (November 2002). "Resistin and adiponectin ... Wulster-Radcliffe MC, Ajuwon KM, Wang J, Christian JA, Spurlock ME (April 2004). "Adiponectin differentially regulates ...
Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor ... Agonist of the adiponectin receptor 2 (AdipoR2). Inhibition of mammalian thioredoxin reductase Quick, Andrew; Rogers, Donald ( ...
Adiponectin (together with leptin, it regulates adipose tissue metabolism. It is activated by PPAR inhibitors such as ... It also blocks the beneficial actions of adiponectin. Rimonabant inhibits these and so it reduces appetite, balances energy, ... and increases adiponectin, which reduces intra-abdominal fat. It improves lipid profile, glucose tolerance, and waist ...
Adiponectin has several properties that protect the liver. These properties include improved liver fat metabolism, decreased de ... Adipose tissue dysfunction also decreases secretion of the insulin-sensitizing adipokine adiponectin in people with NAFLD. ...
Adiponectin has also been shown to increase the rate of fatty acid transport and oxidation in mice, which causes an increase in ... The adiponectin genes regulate glucose metabolism as well as fatty acid breakdown; however, the exact mechanisms are not ... Therefore, there was less adiponectin to help cells take up glucose and break down fat, as well as less leptin to cause a ... With a high fat diet during gestation, there was an increase in methylation in the promoter of the adiponectin gene accompanied ...
"Isolation and quantitation of adiponectin higher order complexes". Methods in Enzymology. Methods of Adipose Tissue Biology, ...
It is believed that centenarians possess a different adiponectin isoform pattern and have a favorable metabolic phenotype in ... "Assessment of adiponectin and its isoforms in Polish centenarians". Exp Gerontol. 48 (4): 401-7. doi:10.1016/j.exger.2013.01. ...
February 2010). "Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype". The Journal of Biological ...
June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762-9. Bibcode: ... such as microbial rhodopsins and adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2). However, these 7TMH (7-transmembrane ...
Jardé T, Perrier S, Vasson MP, Caldefie-Chézet F (January 2011). "Molecular mechanisms of leptin and adiponectin in breast ...
Adiponectin induces reverse cholesterol transport by an ABCA1-dependent pathway. Other endogenous metabolites more loosely ... Hafiane A, Gasbarrino K, Daskalopoulou SS (2019). "The role of adiponectin in cholesterol efflux and HDL biogenesis and ...
Adiponectin is a protein hormone that has been shown to be upregulated in rheumatoid arthritis disease pathology, causing the ... In primary human cell cultures Sp7 was shown to be inhibited by adiponectin thus contributing downregulation of the creation of ... May 2017). "Response of human rheumatoid arthritis osteoblasts and osteoclasts to adiponectin". Clinical and Experimental ...
"In vitro and in vivo effects of adiponectin on bone." Endocrinology 150, no. 8 (2009): 3603-3610. Naot, Dorit, Andrew Grey, Ian ...
WAT is also the source of adipokines and inflammatory markers which have both positive (e.g., adiponectin) and negative effects ... Ye R, Scherer PE (April 2013). "Adiponectin, driver or passenger on the road to insulin sensitivity?". Molecular Metabolism. 2 ... Recently, MAT was noted to "produce a greater proportion of adiponectin - an adipokine associated with improved metabolism - ... August 2014). "Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during ...
It also inhibits lipolysis and stimulates the secretion of adiponectin. These effects are thought to be mostly conferred via ... lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and isolated primary rat adipocytes". Diabetologia. 54 (7 ...
"Essential role of mitochondrial function in adiponectin synthesis in adipocytes". Diabetes. 56 (12): 2973-81. doi:10.2337/db07- ...
But adiponectin, an anti-inflammatory adipokine, which is found in lower concentration in obese and diabetic individuals has ... August 2015). "Adiponectin as a Protective Factor Against the Progression Toward Type 2 Diabetes Mellitus in Postmenopausal ... Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ (October 2003). "Plasma resistin, adiponectin and leptin levels ... June 2004). "Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity". Obesity Research ...
Ghoshal, K; Bhattacharyya, M (2015). "Adiponectin: Probe of the molecular paradigm associating diabetes and obesity". World J ... Ghoshal, K., & Bhattacharyya, M. (2015). Adiponectin: Probe of the molecular paradigm associating diabetes and obesity. World ...
... and adiponectin". Peptides. 27 (4): 911-6. doi:10.1016/j.peptides.2005.12.014. PMID 16476508. Steckelings, U; Kaschina, E; ...
Like leptin, observations in both humans and animal models have shown that adiponectin is relevant to insulin sensitivity and ... Research into the adipose-derived hormones adiponectin and resistin is ongoing. Like leptin, these hormones also affect energy ... Adipose tissue is an endocrine organ that secretes numerous protein hormones, including leptin, adiponectin, and resistin. ...
"APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function". Nature Cell Biology. 8 (5): 516-23. doi ... Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A (May 2007). "Adiponectin-induced endothelial nitric oxide ...
Circulating adiponectin levels have been shown to be reduced in obese women. These reduced levels of adiponectin have also been ... Adiponectin, the protein secreted in greatest amounts from adipocytes, functions to increase the sensitivity of cells to ...
Adiponectin exerts some of its weight reduction effects via the brain. This is similar to the action of leptin; adiponectin and ... Adiponectin is a 244-amino-acid-long polypeptide (protein). There are four distinct regions of adiponectin. The first is a ... Adiponectin is apparently able to cross the blood-brain-barrier. However, conflicting data on this issue exist. Adiponectin has ... Adiponectin promoted synaptic and memory function in the brain. Humans with lower levels of adiponectin have reduced cognitive ...
... which are bound and activated by adiponectin: Adiponectin receptor 1 (AdipoR1, PAQR1) Adiponectin receptor 2 (AdipoR2, PAQR2) ... The adiponectin receptors (AdipoRs) include the following two receptors, ...
Adiponectin is an adipocyte-derived secretory protein that has been very widely studied over the past 15 years. A multitude of ... Adiponectin receptors. Adiponectins actions are mediated through a number of receptors, such as adiponectin receptors 1 and 2 ... Low adiponectin correlates with albuminuria in both mice and humans [31, 32]. Lack of adiponectin has been linked to increased ... Adiponectin and the liver. Adiponectin has several effects on the liver. One of the most prominent of these is suppression of ...
These data are novel and appear to be suggestive of a primary role of adiponectin in β-cell function. We consider this ... Based on the findings in the study by Bacha et al., we investigated whether plasma adiponectin is associated with parameters of ... Bacha F, Saad R, Gungor N, Arslanian SA: Adiponectin in youth: relationship to visceral adiposity, insulin sensitivity and β- ... Rakatzi I, Mueller H, Ritzeler O, Tennagels N, Eckel J: Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in ...
0.02 with adiponectin and insulin sensitivity in the formula; R2 = 0.162, P = 0.007 with only adiponectin in the formula). Also ... 1) in this issue of Diabetes Care regarding adiponectin in youth. We are excited to have received the opinion of investigators ... Stefan N, Stumvoll M, Häring H, Fritsche A: Adiponectin in youth (Letter). Diabetes Care 27:1519-1520, 2004. ... We never implied that a direct effect of adiponectin on insulin secretory function exists. However, as recommended by Stefan et ...
Analysis of serum adiponectin at day 1 or day 6 after respiratory failure showed that low levels of adiponectin at the earlier ... Adiponectin plays a role in the inflammatory components of cardiovascular diseases. To begin with, lack of adiponectin in a ... 1. Adiponectin. Adiponectin is a cytokine, "adipokine", produced almost exclusively in adipose tissue and is expressed at high ... Figure 1: Adiponectin levels and inflammatory state. In healthy individuals, adiponectin maintains anti-inflammatory properties ...
Immunohistochemistry of adiponectin in human kidneys and determination of urinary adiponectin isoforms by Western blot.. A ... Low-molecular adiponectin isoforms (∼30-70 kDa) were detected in urine by Western blot analysis. Urinary adiponectin was ... percentile) of the adiponectin excretion rate in healthy control subjects (→urinary adiponectin ,10.61 μg/g creatinine). FPG ... Serum adiponectin was significantly lower and urinary adiponectin levels significantly higher in patients with type 2 diabetes ...
Adiponectin exerts some of its weight reduction effects via the brain. This is similar to the action of leptin;[19] adiponectin ... Lower levels of adiponectin are associated with ADHD in adults.[38]. Adiponectin levels were found to be increased in ... Regulation of adiponectin *Obesity is associated with decreased adiponectin. *The exact mechanism of regulation is unknown, but ... Adiponectin is a 247-amino-acid-long polypeptide (protein). There are four distinct regions of adiponectin. The first is a ...
In healthy adults, adiponectin circulates in serum at a high concentration (1.9-17.0 μg/ml). Adiponectin levels are ... The adiponectin paralogs, CTRPs 1-7, were identified by searching GenBank EST and genomic databases with the adiponectin cDNA ... CTRP May Compensate for Loss of Adiponectin. Three separate lines of adiponectin-/- mice have recently been generated (46-48) ... Identification and Analysis of Acrp30/Adiponectin Paralogs. By using the adiponectin cDNA sequence to interrogate the mouse and ...
Adiponectin as a biomarker of the metabolic syndrome.. Ryo M1, Nakamura T, Kihara S, Kumada M, Shibazaki S, Takahashi M, Nagai ... 1.51 for women with adiponectin concentrations ,4.0 microg/ml. In all, 52.3% of men and 37.5% of women with adiponectin ... Adiponectin is an adipose-derived plasma protein with anti-atherogenic and insulin-sensitizing activities. ... Plasma adiponectin concentrations correlated negatively with waist circumference, visceral fat area, serum triglyceride ...
Mice fed a high-iron diet and cultured adipocytes treated with iron exhibited decreased adiponectin mRNA and protein. We found ... Ferritin was increased and adiponectin was decreased in type 2 diabetic and in obese diabetic subjects compared with those in ... We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic ... In humans, normal-range serum ferritin levels were inversely associated with adiponectin, independent of inflammation. ...
Present study presents the current knowledge about the presence and role of adiponectin system (adiponectin and its receptors: ... The presence of adiponectin and its receptors in the structures responsible for the regulation of female reproductive functions ... The growing body of evidence suggests also that adiponectin action is dependent on the actual and hormonal status of the animal ... The hormone plays pleiotropic roles in the organism, but the most important function of adiponectin is the control of energy ...
Adiponectin also elicited an AdipoR1-dependent increase in Ca2+ influx, which played a critical role in the pathway leading to ... Adiponectin signaling through AdipoR1 appeared to increase the abundance of the mRNA encoding PGC-1α through a CaMKKβ-dependent ... Adiponectin, a hormone released from adipose tissue that has antidiabetic activity, signals through seven-transmembrane ... Noting that adiponectin deficiency promotes insulin resistance and that insulin resistance is associated with mitochondrial ...
Maternal serum total adiponectin (A), HMW adiponectin (B), MMW adiponectin (C) and LMW adiponectin (D) concentrations in women ... Comparison of HMW/Total adiponectin (A) MMW/Total adiponectin (B) and LMW/Total adiponectin (C) ratios between in women with a ... Comparison of HMW/Total adiponectin MMW/Total adiponectin and LMW/Total adiponectin ratios between pregnant women with normal ... In contrast, patients with GDM had a higher median MMW/Total adiponectin and LMW/Total adiponectin ratios than those with a ...
One review suggests adiponectin may be to blame ... EndoType: Is Adiponectin Behind Statin, Diabetes Link?. by ... The impact of statins on adiponectin hasnt been consistent, but one statin -- pitavastatin (Livalo) -- increased adiponectin ... The "adiponectin theory" is still controversial, notes David Bell, MD, of the University of Alabama at Birmingham, but a statin ... A new review, published in Diabetes, Obesity, and Metabolism, suggests that the hormone adiponectin may have something to do ...
We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic ... In humans, normal-range serum ferritin levels were inversely associated with adiponectin, independent of inf … ... Adipocyte iron regulates adiponectin and insulin sensitivity J Clin Invest. 2012 Oct;122(10):3529-40. doi: 10.1172/JCI44421. ... Mice fed a high-iron diet and cultured adipocytes treated with iron exhibited decreased adiponectin mRNA and protein. We found ...
... , High Blood Pressure ... Adiponectin may also be involved in the progression of hypertension. On a high-salt diet, Ohashi et al showed that adiponectin- ... Reconstitution of adiponectin expression by adenoviral infection restored normal blood pressure. Overexpression of adiponectin ... The only hormone displaying an opposite trend is adiponectin. Adiponectin levels have been positively associated with insulin ...
Rabbit polyclonal Adiponectin antibody. Validated in WB and tested in Human. Cited in 7 publication(s). Immunogen corresponding ... SDS-PAGE 12% separation of human adiponectin 5. µ. g / line.. SDS-PAGE 12% separation of human adiponectin 5µg / line. ... Defects in ADIPOQ are the cause of adiponectin deficiency (ADPND) [MIM:612556]. ADPND results in very low concentrations of ... Hydroxylation and glycosylation of the lysine residues within the collagene-like domain of adiponectin seem to be critically ...
Pharmacological Actions : Adiponectin upregulation, Hypoglycemic Agents. Additional Keywords : Adiponectin: Low Levels, ... Diseases : Adiponectin: Low Levels, Diabetic Complications. Pharmacological Actions : Adiponectin upregulation, Hypoglycemic ... Pharmacological Actions : Adiponectin upregulation, Anti-Inflammatory Agents, Leptin Down-Regulation. Additional Keywords : ... Pharmacological Actions : Adiponectin upregulation, Anti-Inflammatory Agents, Hypolipidemic, Tumor Necrosis Factor (TNF) Alpha ...
... we examined the longitudinal association between asthma and adiponectin and found that low serum adiponectin concentrations, ... Low serum adiponectin concentrations were a more important predictor of risk for incident asthma than body mass index. Having ... Low serum adiponectin levels predict an increased future risk for developing asthma in middle-aged women, particularly among ... Being in the lowest tertile of serum adiponectin concentrations (,7 mg/L) at year 15 was a significant predictor of a higher ...
The binding of adiponectin with its specific receptors induces the activation of a proper signaling cascade that becomes ... also highlighting the beneficial role of adiponectin in autophagy activation and hepatic regeneration. ... adiponectin regulates both glucose and lipid metabolism and exerts an insulin-sensitizing effect. ... In the liver, adiponectin regulates both glucose and lipid metabolism and exerts an insulin-sensitizing effect. The binding of ...
... and adiponectin. Participants were 394 police officers from Buffalo, NY. Objective data on shift work were obtained from daily ... and adiponectin. Participants were 394 police officers from Buffalo, NY. Objective data on shift work were obtained from daily ...
We designed a nested case-control study to assess whether baseline adiponectin concentrations in plasma are independently ... Adiponectin is an adipocyte-derived peptide, which has anti-inflammatory and insulin-sensitising properties. ... Adiponectin and protection against type 2 diabetes mellitus Lancet. 2003 Jan 18;361(9353):226-8. doi: 10.1016/S0140-6736(03) ... We found that adiponectin concentrations in plasma were lower among individuals who later developed type 2 diabetes than among ...
Human Adiponectin SimpleStep ELISA® Kit is a highly sensitive, single-wash 90 min immunoassay suitable for Serum, Hep Plasma, ... Decreased levels of adiponectin are associated with insulin resistance, whereas high levels of adiponectin are associated with ... The concentrations of Adiponectin were measured in duplicates, interpolated from the Adiponectin standard curves and corrected ... The concentrations of Adiponectin were measured in duplicates, interpolated from the Adiponectin standard curves and corrected ...
Compare Adiponectin Receptor 2 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews ... Adiponectin Receptor 2 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a widely used application for detecting and ... Your search returned 96 Adiponectin Receptor 2 ELISA ELISA Kit across 16 suppliers. ...
2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116:1784 ... Moreover, adiponectin signaling seems to also be impaired, with decreased expression of adiponectin receptor 1 and 2 in women ... Prepubertal mice overexpressing adiponectin from adipose tissue (APNtg), adiponectin knockouts (APNko), and their wild-type (WT ... 2009) Omental fat expression of adiponectin and adiponectin receptors in non-obese women with PCOS: A preliminary study. Reprod ...
Adiponectin Receptor Detection. Human adiponectin is a protein hormone secreted by adipocytes that is involved in several ... Antibodies for Adiponectin Receptor Detection. Anti-adiponectin receptor antibodies are affinity-purified IgG antibodies that ... Anti-Human Adiponectin Receptor 2 Rabbit IgG Affinity Purify 10 ug $121.00 ... Anti-Human Adiponectin Receptor 1 Rabbit IgG Affinity Purify 10 ug $121.00 ...
However, plasma adiponectin levels were not measured in these studies. In the present study, we measured plasma adiponectin ... Determination of plasma adiponectin concentration.. The concentration of plasma adiponectin was determined by the enzyme-linked ... 8.6 ± 0.4 μg/ml). The difference in plasma adiponectin level was still significant when plasma adiponectin levels of the ... Indeed, we have screened the 2-kb promoter region of adiponectin gene, which might affect the adiponectin production, in 99 ...
Adiponectin, Acrp30, AdipoQ, GBP-28, APM-1, ACDC, Trimeric Form, Globular Adiponectin, Human, Mouse, Recombinant ... About Adiponectin:. The gene symbol is ADIPOQ [adiponectin, C1q and collagen domain containing].. Another designation is ACDC [ ... Adiponectin may thus attenuate inflammation associated with atherogenesis.. Adiponectin specifically binds to collagen type 1, ... Yamauchi et al (2004) have cloned the cDNAs for two adiponectin receptors, both of which bind full-length adiponectin and ...
Adiponectin is known to be a pleiotropic organ-protective protein that is exclusively produced by adipocytes and decreased in ... Adiponectin accumulates in tissues such as heart, muscle, and vascular endothelium through binding with T-cadherin, a ... Recently, adiponectin was found to enhance exosome biogenesis and secretion, leading to a decrease in cellular ceramides, ... This review focuses on intra-adipose and interorgan communication by exosomes, adiponectin-stimulated exosome production, and ...
  • So far, two receptors have been identified with homology to G protein-coupled receptors, and one receptor similar to the cadherin family: Adiponectin receptor 1 (AdipoR1) Adiponectin receptor 2 (AdipoR2) T-cadherin - CDH13 These have distinct tissue specificities within the body and have different affinities to the various forms of adiponectin. (wikipedia.org)
  • Although it binds adiponectin, it is not a signalling receptor per se, as it lacks an intracellular signalling domain. (springer.com)
  • We consider this hypothesis to be valid, especially since expression of adiponectin receptor 1 and 2 was recently detected in β-cells ( 2 ). (diabetesjournals.org)
  • The adiponectin receptors (AdipoRs) include the following two receptors, which are bound and activated by adiponectin: Adiponectin receptor 1 (AdipoR1, PAQR1) Adiponectin receptor 2 (AdipoR2, PAQR2) They are members of the progestin and adipoQ receptor (PAQR) family. (wikipedia.org)
  • Your search returned 96 Adiponectin Receptor 2 ELISA ELISA Kit across 16 suppliers. (biocompare.com)
  • Two receptors for adiponectin have been identified that share homology with the G protein-coupled receptors (GPCRs): adiponectin receptor 1 (ADIPOR1) and adiponectin receptor 2 (ADIPOR2). (clontech.com)
  • Binding of adiponectin to ADIPOR2 mediates increased AMP-activated protein kinase (AMPK) activity, peroxisome proliferator-activated receptor-alpha (PPAR-alpha) ligand activity, fatty acid oxidation, and glucose uptake. (clontech.com)
  • Anti-adiponectin receptor antibodies are affinity-purified IgG antibodies that recognize human adiponectin receptor protein variants. (clontech.com)
  • The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages). (peprotech.com)
  • The following antibody was used in this experiment: Adiponectin Receptor 1 Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-35347, RRID AB_2552657. (thermofisher.com)
  • The following antibody was used in this experiment: Adiponectin Receptor 1 Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA1-12757, RRID AB_2305063. (thermofisher.com)
  • Synthetic peptide corresponding to human Adiponectin Receptor 1. (thermofisher.com)
  • Recently we developed and characterized a first-in-class peptide-based adiponectin receptor agonist by using in vitro and in vivo models of glioblastoma and breast cancer (BC). (frontiersin.org)
  • Adiponectin and osmotin, the two receptor binding proteins do not share sequence similarity at the amino acid level, but interestingly they have a similar structural and functional properties. (frontiersin.org)
  • 20 Adiponectin Receptor 2 (ADIPOR2) ELISA Kits from 8 manufacturers are available on www.antibodies-online.com. (antibodies-online.com)
  • Adipocyte-derived adiponectin (APN) is involved in the protection against cardiovascular disease, but the endogenous APN and its receptor expression in the perivascular adipocytes and their role in hypertensive vascular injury remain unclear. (spandidos-publications.com)
  • Adiponectin, as a fat-derived hormone, fulfills a critical role as an important messenger between adipocytes and other organs through the adiponectin receptor 1 and/or receptor 2 (AdipoR1/R2). (spandidos-publications.com)
  • Methods: We generated three types of gene-deficient mice (adiponectin-deficient, adiponectin receptor 1- deficient, and adiponectin receptor 2-deficient) and investigated chemical-induced colon polyp formation and cell proliferation in colon epithelium. (ebscohost.com)
  • Similarly, an increase in epithelial cell proliferation was observed in adiponectin receptor 1-deficient mice, but not in adiponectin receptor 2-deficient mice. (ebscohost.com)
  • Adiponectin was first characterised in 1995 in differentiating 3T3-L1 adipocytes (Scherer PE et al. (wikipedia.org)
  • The larger adipocytes found in obese subjects produce lower levels of adiponectin but higher levels of proinflammatory cytokines, such as TNF α [ 7 ]. (hindawi.com)
  • Adiponectin inhibits the expression of TNF- α in adipocytes, and both TNF- α and IL-6 inhibit the production of adiponectin [ 9 , 10 ]. (hindawi.com)
  • Adiponectin is expressed exclusively by differentiated adipocytes and its expression is induced ≈100-fold during adipocyte differentiation ( 2 ). (pnas.org)
  • Mice fed a high-iron diet and cultured adipocytes treated with iron exhibited decreased adiponectin mRNA and protein. (jci.org)
  • These findings demonstrate a causal role for iron as a risk factor for metabolic syndrome and a role for adipocytes in modulating metabolism through adiponectin in response to iron stores. (jci.org)
  • Human adiponectin is a protein hormone secreted by adipocytes that is involved in several metabolic functions, including the regulation of glucose levels and fatty acid metabolism. (clontech.com)
  • Schaffler et al (1999) have shown that the Adiponectin gene is expressed by differentiated adipocytes. (prospecbio.com)
  • Adiponectin is known to be a pleiotropic organ-protective protein that is exclusively produced by adipocytes and decreased in obesity. (jci.org)
  • Abdominal adipose tissue volumes/distribution did not differ in the groups, but PCOS women had higher waist-to-hip ratio, enlarged adipocytes, reduced adiponectin, and lower LPL activity. (wellnessresources.com)
  • Enlarged adipocytes and reduced serum adiponectin, together with a large waistline, rather than androgen excess, may be central factors in the pathogenesis/maintenance of insulin resistance in PCOS. (wellnessresources.com)
  • Such role is performed by means of the activity of several proteins secreted by adipocytes (adipocytokines), 8 such as adiponectin. (isciii.es)
  • To identify new antidiabetic mechanisms of ARBs, we studied the regulation of adiponectin by angiotensin II (Ang II) and different ARBs in murine 3T3-L1 adipocytes and obese Zucker rats. (ahajournals.org)
  • The present study demonstrates that AT2R activation and certain ARBs induce adiponectin in adipocytes, which was associated with an improvement of parameters of insulin sensitivity in vivo. (ahajournals.org)
  • Adiponectin belongs to the family of adipocytokines, is exclusively synthesized by white adipocytes, and is induced during adipocyte differentiation. (ahajournals.org)
  • To identify new insulin-sensitizing/antidiabetic effects of ARBs, we studied the regulation of adiponectin expression by ARBs and Ang II in murine 3T3-L1 adipocytes, which express AT1R and AT2R. (ahajournals.org)
  • Adiponectin is manufactured and secreted solely by adipocytes, and is a highly obtained plasma protein, accounting for up to 0.05% of total serum protein. (prospecbio.com)
  • Adiponectin is the most abundant peptide secreted by adipocytes, whose reduction plays a central role in obesity-related diseases, including insulin resistance/type 2 diabetes and cardiovascular disease. (mdpi.com)
  • 8 This inflammatory state is related to adipokines-proteins mainly produced by adipocytes-which may be pro-inflammatory (such as leptin) or anti-inflammatory (such as adiponectin). (bmj.com)
  • Adiponectin, also known as Adipocyte Complement-Related Protein of 30 kDa (Acrp30), is secreted from adipocytes and has been implicated in energy homeostasis and obesity. (rndsystems.com)
  • Adiponectin is a hormone secreted mainly from adipocytes 3 that stimulates glucose utilization 4 and fatty-acid oxidation 5 . (pubmedcentralcanada.ca)
  • Taken together, these findings show that adiponectin, derived from adipocytes, negatively regulates the invasiveness of breast cancer cells by activating the tumor suppressor PP2A. (aacrjournals.org)
  • Adiponectin (Acrp30, in mouse) is a hormone secreted by differentiated adipocytes that regulates energy homeostasis and glucose and lipid metabolism. (perkinelmer.com)
  • Adiponectin is one of the adipose tissue hormones synthesized and released mainly by mature adipocytes of visceral white adipose tissue. (springer.com)
  • Globular ACRP-30, gACRP-30, is a naturally occurring cleavage product of adiponectin, a molecule made exclusively by adipocytes. (cellsciences.com)
  • Hypoxia-inducible factor 1α regulates a SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes. (sigmaaldrich.com)
  • Here, acriflavine (ACF), an inhibitor of HIF1α, induced the expression of adiponectin and reduced the expression of SOCS3 in cultured 3T3-L1 adipocytes. (sigmaaldrich.com)
  • STAT3 directly regulated adiponectin in vitro in cultured 3T3-L1 adipocytes. (sigmaaldrich.com)
  • We recently reported that adiponectin synthesis is regulated by mitochondrial function in adipocytes. (scialert.net)
  • This study was undertaken to test the hypothesis that endothelial NO synthase (eNOS) plays an important role in adiponectin synthesis by producing NO and enhancing mitochondrial function in adipocytes. (scialert.net)
  • We examined the effects of eNOS knockdown on adiponectin synthesis in 3T3-L1 adipocytes and also examined plasma adiponectin levels and the mitochondria in adipose tissue of eNOS knockout (eNOS -/- ) mice with and without chronic administration of a NO donor. (scialert.net)
  • In cultured 3T3-L1 adipocytes, eNOS siRNA decreased rosiglitazone-induced adiponectin secretion, which was associated with decreases in mitochondrial proteins and biogenesis factors. (scialert.net)
  • eNOS plays an important role in adiponectin synthesis in adipocytes by increasing mitochondrial biogenesis and enhancing mitochondrial function. (scialert.net)
  • Because insulin resistance in the setting of obesity has also been associated with the development of breast cancer, we have hypothesized that decreased adiponectin levels might underlie the association between breast cancer and obesity/insulin resistance. (nih.gov)
  • Decreased adiponectin levels are associated with insulin resistance and obesity. (gu.se)
  • Adiponectin in combination with leptin has been shown to completely reverse insulin resistance in mice. (wikipedia.org)
  • adiponectin and leptin can act synergistically. (wikipedia.org)
  • Associations with shift work with leptin, insulin, and adiponectin. (cdc.gov)
  • Our objective was to investigate cross-sectional associations between shift work and three biomarkers of metabolic function: leptin, insulin, and adiponectin. (cdc.gov)
  • Adipose tissue plays an important role in insulin resistance syndrome through the dysregulated production and secretion of adipose-derived proteins, including tumor necrosis factor-α, plasminogen activator inhibitor-1, leptin, resistin, angiotensinogen, and adiponectin ( 1 - 7 ). (diabetesjournals.org)
  • Adipose tissue also produces a variety of secreted factors called adipocytokines, including leptin and adiponectin. (jci.org)
  • Cord blood was analyzed for adiponectin, leptin, and insulin levels. (unboundmedicine.com)
  • An improvement in inflammatory markers was seen with an increase in adiponectin, adiponectin/leptin ratio and inteleukin-15. (scielo.br)
  • Moreover, a positive correlation between the adiponectin/leptin ratio and osteocalcin was demonstrated. (scielo.br)
  • Negative associations between leptin with osteocalcin, adiponectin with Beta CTX-collagen, and visceral fat with adiponectin were observed. (scielo.br)
  • Studies on adipocyte-derived adiponectin and leptin reveal opposing effects on BC cell proliferation in vitro, suggesting they may play a role in BC pathogenesis. (spandidos-publications.com)
  • In the current study we examined effects on proliferation of five BC cell lines treated with varying adiponectin:leptin (A/L) ratios. (spandidos-publications.com)
  • This is due largely to their secretory profile of adipokines such as leptin, adiponectin, hepatocyte growth factor, collagen VI, interleukin 6, and tumor necrosis factor α ( 3 ). (aacrjournals.org)
  • Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein hormone and adipokine, which is involved in regulating glucose levels as well as fatty acid breakdown. (wikipedia.org)
  • Biochemical, genetic, and animal studies in recent years have established a critical role for the adipokine Acrp30/adiponectin in controlling whole-body metabolism, particularly by enhancing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. (pnas.org)
  • Acrp30/adiponectin is one such adipokine discovered in a screen to identify novel secreted proteins induced upon adipocyte differentiation ( 2 ). (pnas.org)
  • Adiponectin, also referred to as AdipoQ or ACRP30, is a plasma protein produced and secreted exclusively from adipose tissue. (diabetesjournals.org)
  • Recently, several groups have demonstrated that administration of ACRP30/adiponectin increased fatty acid oxidation in muscles and decreased hepatic glucose production, resulting in amelioration of insulin resistance and improvement of glucose metabolism in diabetic mice ( 17 - 20 ). (diabetesjournals.org)
  • The Recombinant Human Adiponectin/Acrp30 Animal-Free Protein has been validated for the following applications: SDS-Page, Bioactivity. (fishersci.com)
  • We offer Adiponectin/Acrp30 Peptides and Adiponectin/Acrp30 Proteins for use in common research applications: Blocking/Neutralizing, Control, ELISA, Functional, Protein Array, SDS-Page, Western Blot. (novusbio.com)
  • Each Adiponectin/Acrp30 Peptide and Adiponectin/Acrp30 Protein is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Our Adiponectin/Acrp30 Peptides and Adiponectin/Acrp30 Proteins can be used in a variety of model species: Human, Mouse, Rat. (novusbio.com)
  • Choose from our Adiponectin/Acrp30 Peptides and Proteins. (novusbio.com)
  • Adiponectin (also known as Adipocyte complement-related protein of 30 kDa, Acrp30) is an adipocyte-derived protein with wide ranging paracrine and endocrine effects on metabolism and inflammation. (rndsystems.com)
  • It has been demonstrated that Adiponectin / Acrp30 plays a major role in controlling whole-body metabolism, particularly by enhancing insulin sensitivity in muscle and liver, and by augmenting the oxydation of fatty acids in muscle. (perkinelmer.com)
  • In contrast, adiponectin, also referred to as adipocyte complement-related protein 30 (ACRP30), is an antiinflammatory adipokine that is abundantly present in blood stream. (ahajournals.org)
  • Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 aminoacid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells. (biovendor.com)
  • Defects in ADIPOQ are the cause of adiponectin deficiency (ADPND) [MIM:612556]. (abcam.com)
  • The gene symbol is ADIPOQ [adiponectin, C1q and collagen domain containing]. (prospecbio.com)
  • AICAR-mediated protection occurred independently of adiponectin, as similar protection was observed in wild-type and Adipoq −/− mice. (springer.com)
  • ADIPOQ - adiponectin, C1Q and collagen domain. (wikigenes.org)
  • Objective The adiponectin gene (ADIPOQ) has been suggested to be associated with the pathogenesis of colorectal cancer (CRC). (medsci.org)
  • Nous avons génotypé les deux polymorphismes mononucléotidiques du gène ADIPOQ chez 140 patients atteints de DNID sans lien de parenté et 66 témoins non diabétiques en recourant à l'analyse du polymorphisme de longueur des fragments de restriction par réaction en chaîne de polymérase. (who.int)
  • SNPs at the adiponectin-encoding ADIPOQ locus demonstrated the strongest associations with adiponectin levels (P-combined = 9.2×10−19 for lead SNP, rs266717, n = 14,733). (harvard.edu)
  • Present study presents the current knowledge about the presence and role of adiponectin system (adiponectin and its receptors: AdipoR1 and AdipoR2) in the ovaries, oviduct, and uterus, as well as in the hypothalamus and pituitary, the higher branches of HPG axis, involved in the female fertility regulation. (hindawi.com)
  • Adiponectin, a hormone released from adipose tissue that has antidiabetic activity, signals through seven-transmembrane receptors (AdipoR1 and AdipoR2) that are structurally and functionally distinct from the more familiar seven-transmembrane G protein-coupled receptors. (sciencemag.org)
  • AdipoR1 & AdipoR2 are the 2 signaling receptors for adiponectin and gAcrp30 that were recently been identified. (prospecbio.com)
  • The adiponectin receptors, ADIPOR1 and ADIPOR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-alpha ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin. (thermofisher.com)
  • Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning. (thermofisher.com)
  • Adiponectin effects are mediated by adiponectin receptors, which occur as two isoforms (AdipoR1 and AdipoR2). (mdpi.com)
  • Two adiponectin receptors, AdipoR1 and AdipoR2, have been identified. (frontiersin.org)
  • Here we describe the crystal structure of ADIPOR2 bound to a FFA molecule and show that ADIPOR2 possesses intrinsic basal ceramidase activity that is enhanced by adiponectin. (rcsb.org)
  • The key roles of adiponectin in regulating energy homeostasis and glucose metabolism are mediated by two integral membrane proteins, named ADIPOR1 and ADIPOR2 9 . (pubmedcentralcanada.ca)
  • Recently, the pleiotropic actions of adiponectin were linked to the ceramide signaling pathway as ADIPOR1 and ADIPOR2 activation was shown to lower ceramide levels via the activation of a ceramidase activity measured in crude cell lysates 1 . (pubmedcentralcanada.ca)
  • Given that the levels of adiponectin vary in different inflammatory diseases as discussed above, these data suggest that the metabolic consequences observed in obesity may be related to an imbalance of pro- and anti-inflammatory cytokines. (hindawi.com)
  • Low adiponectin levels are inversely related to high levels of C-reactive protein (CRP) in patients with obesity, type 2 diabetes, and CAD [ 13 - 15 ]. (hindawi.com)
  • Thus, adiponectin mediates protective effects in obesity-related metabolic and vascular disease presumably by its anti-inflammatory actions and protects the heart against ischemia-reperfusion injury through its ability to suppress myocardial inflammation and apoptosis [ 23 ]. (hindawi.com)
  • The discovery of a family of adiponectin paralogs has implications for understanding the control of energy homeostasis and could provide new targets for pharmacologic intervention in metabolic diseases such as diabetes and obesity. (pnas.org)
  • A new review, published in Diabetes, Obesity, and Metabolism , suggests that the hormone adiponectin may have something to do with it. (medpagetoday.com)
  • In the current study, we examined the longitudinal association between asthma and adiponectin and found that low serum adiponectin concentrations, independent of obesity, predicted a higher risk for developing asthma. (redorbit.com)
  • The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. (peprotech.com)
  • Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. (peprotech.com)
  • While obesity is a well-known cause of cardiovascular disease, research from the Sahlgrenska Academy at the University of Gothenburg, Sweden, has now revealed that the body's obesity hormones - adiponectin - are also linked to osteoporosis and an increased risk of fractures. (innovations-report.com)
  • As part of an international research project studying the risk factors associated with osteoporosis in elderly men, he and his colleagues have been looking into the obesity hormone adiponectin. (innovations-report.com)
  • 7 In parallel, the regulation of adiponectin serum levels and metabolic parameters by ARB treatment was examined in obese Zucker rats, a model of obesity-induced insulin-resistance. (ahajournals.org)
  • Therefore, adiponectin replacement therapy in humans may suggest potential versatile therapeutic targets in the treatment of obesity, insulin resistance/type 2 diabetes, and atherosclerosis. (mdpi.com)
  • The current knowledge on regulation and function of adiponectin in obesity, insulin resistance, and cardiovascular disease is summarized in this review. (mdpi.com)
  • AICAR may promote metabolic health and protect against obesity-induced systemic diseases in an adiponectin-independent manner. (springer.com)
  • As we cannot exclude the compromising role of adiponectin in CKD patient groups, it is critical to assess if AICAR-mediated actions are adiponectin dependent to determine its suitability as a drug to target obesity-related pathophysiology. (springer.com)
  • Although the association of adiponectin with several diseases remains controversial, many clinical studies have demonstrated that low plasma concentrations of adiponectin (hypoadiponectinaemia) associate closely with obesity-related diseases, including atherosclerotic cardiovascular diseases, Type II diabetes mellitus, hypertension and dyslipidaemia. (portlandpress.com)
  • Although evaluation of adiponectin as a novel therapy will ultimately require clinical intervention studies, this mediator may represent a novel target for the prevention and treatment of visceral obesity metabolic syndrome. (portlandpress.com)
  • Several recent studies have shown that low serum adiponectin is highly associated with obesity-related cancers, including endometrial, breast, prostate, and gastric cancers. (aacrjournals.org)
  • The present review highlights recent research advances in unveiling the molecular mechanisms that underpin the vascular actions of adiponectin and discusses the potential strategies of using adiponectin or its signalling pathways as therapeutic targets to combat obesity-related metabolic and vascular diseases. (portlandpress.com)
  • Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. (springer.com)
  • Genetic ablation of HIF1α in adipose tissue decreased insulin resistance and obesity, accompanied by increased serum adiponectin levels. (sigmaaldrich.com)
  • Xu J, Lai KK, Verlinsky A, Lugea A, French SW, Cooper MP, Ji C, Tsukamoto H. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. (umassmed.edu)
  • Low plasma adiponectin levels, also known as hypoadiponectinemia, are closely associated with the increased prevalence of obesity-linked disorders including type 2 diabetes, coronary heart disease, and hypertension. (ahajournals.org)
  • 14 Thus, adiponectin exerts beneficial actions on the obesity-related metabolic and cardiovascular complications, at least in part, through its ability to control inflammatory responses. (ahajournals.org)
  • looked for a link between adiponectin-AdipoR1 signaling and mitochondria. (sciencemag.org)
  • Having explored the phenotypic effects of a loss of adiponectin signaling through AdipoR1, the authors investigated the underlying pathway. (sciencemag.org)
  • Adiponectin signaling through AdipoR1 appeared to increase the abundance of the mRNA encoding PGC-1α through a CaMKKβ-dependent pathway that did not require AMPK and to stimulate PGC-1α deacetylation by SIRT1, and thereby its activation, through an AMPK-dependent pathway. (sciencemag.org)
  • Adiponectin also elicited an AdipoR1-dependent increase in Ca 2+ influx, which played a critical role in the pathway leading to increased PGC-1α expression and also contributed to adiponectin-mediated AMPK phosphorylation. (sciencemag.org)
  • Thus, the authors conclude that adiponectin signaling through AdipoR1 plays a crucial role in the regulation of mitochondrial function and glucose metabolism. (sciencemag.org)
  • Adiponectin signaling through AdipoR1 plays a crucial role in regulating muscle mitochondrial function. (sciencemag.org)
  • Binding of adiponectin to ADIPOR1 results in activation of an AMP-dependent kinase (AMPK) signaling pathway that regulates fatty acid oxidation and insulin sensitivity. (clontech.com)
  • Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin. (thermofisher.com)
  • Adiponectin is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid oxidation. (wikipedia.org)
  • Also, in an effort to determine if adiponectin is related to an index of glucose homeostasis, we evaluated the correlation of adiponectin with the glucose disposition index (product of insulin sensitivity × first-phase insulin secretion), which revealed that r = 0.35 and P = 0.013. (diabetesjournals.org)
  • Consistently, it was shown in type 2 diabetic patients that adiponectin is lowest in the presence of impaired glucose regulation and early diabetes, whereas long diabetes duration is associated with a significant increase in circulating adiponectin ( 11 ). (diabetesjournals.org)
  • Injection of a proteolytically generated globular C-terminal form of recombinant adiponectin into mice significantly reduced levels of plasma-free fatty acids and glucose after a high-fat meal ( 17 ). (pnas.org)
  • Full-length, but not the globular C-terminal domain of adiponectin produced in mammalian cells, enhanced the ability of insulin to suppress gluconeogenesis and glucose release by primary rat hepatocytes ( 19 ). (pnas.org)
  • Many recent studies (summarized in ref. 20 ) have confirmed and extended these initial findings and corroborated the current notion that adiponectin acts as an insulin sensitizer in vivo , exerting its effects on the liver to suppress glucose output while acting on muscle to increase glucose uptake and fatty acid oxidation. (pnas.org)
  • Plasma adiponectin concentrations correlated negatively with waist circumference, visceral fat area, serum triglyceride concentration, fasting plasma glucose, fasting plasma insulin, and systolic and diastolic blood pressure in both sexes. (nih.gov)
  • Conversely, organismal iron overload and increased adipocyte ferroportin expression because of hemochromatosis are associated with decreased adipocyte iron, increased adiponectin, improved glucose tolerance, and increased insulin sensitivity. (jci.org)
  • Phlebotomy of humans with impaired glucose tolerance and ferritin values in the highest quartile of normal increased adiponectin and improved glucose tolerance. (jci.org)
  • Adiponectin levels have been positively associated with insulin sensitization, glucose use, β-oxidation, and cardiovascular protection. (health.am)
  • In the liver, adiponectin regulates both glucose and lipid metabolism and exerts an insulin-sensitizing effect. (mdpi.com)
  • Wong et al (2004) have described a widely expressed and highly conserved family of seven adiponectin paralogs that can cause increased glycogen accumulation and fatty acid oxidation and/or lower blood glucose levels in ob/ob mice (see: CTRP1, CTRP2, CTRP9). (prospecbio.com)
  • Adiponectin has antiinflammatory capacity, improves glucose tolerance and presents decreased plasma expression and concentration in obese individuals. (isciii.es)
  • Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. (thermofisher.com)
  • Several endoplasmic reticulum ER-associated proteins, including ER oxidoreductase 1-α (Ero1-α), ER resident protein 44 (ERp44), disulfide-bond A oxidoreductase-like protein (DsbA-L), and glucose-regulated protein 94 (GPR94), have recently been found to be involved in the assembly and secretion of higher-order adiponectin complexes. (mdpi.com)
  • In an obese rhesus monkey model, the reduction of adiponectin plasma level was associated with insulin resistance and type 2 diabetes 7 while replenishment of adiponectin was shown to ameliorate insulin resistance and glucose intolerance in mice 8 . (pubmedcentralcanada.ca)
  • α-glucosidase inhibitors are another class of anti-diabetic agents that specifically reduce postprandial blood glucose elevations, but its effect on adiponectin is largely unknown. (nii.ac.jp)
  • So far, scientific studies have been focused on the effect of adiponectin on regulation of glucose and fatty acid metabolism and its connection to cardiovascular system diseases and diabetes mellitus as well as the occurrence of metabolic syndrome. (springer.com)
  • Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. (umassmed.edu)
  • 16 Devaraj et al demonstrated that adiponectin inhibits high glucose-induced CRP production through its ability to suppress nuclear factor-κ B (NF-κB) activation. (ahajournals.org)
  • Adiponectin concentrations correlate negatively with glucose, insulin, triglyceride concentrations, liver fat content and body mass index and positively with high-density lipoprotein-cholesterol levels, hepatic insulin sensitivity and insulin-stimulated glucose disposal. (biovendor.com)
  • Adiponectin has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation. (biovendor.com)
  • These data are novel and appear to be suggestive of a primary role of adiponectin in β-cell function. (diabetesjournals.org)
  • This review explores the recently described role of adiponectin as an immunomodulatory factor and how it intersects with the inflammation associated with both cardiovascular and autoimmune pathologies. (hindawi.com)
  • This review describes the different signaling pathways in healthy and diseased hepatocytes, also highlighting the beneficial role of adiponectin in autophagy activation and hepatic regeneration. (mdpi.com)
  • Recently, several studies have focused on the effects of adiponectin on the endothelium, kidney, and SNS. (health.am)
  • In the absence of a major direct effect of adiponectin on thyroid cancer cell lines, the negative association observed herein may be attributed to the metabolic effects of adiponectin,' the researchers concluded. (endocrineweb.com)
  • The present study was designed to elucidate the effects of adiponectin on matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in human monocyte-derived macrophages. (ahajournals.org)
  • To evaluate the association of adiponectin and sCD40L levels with platelet aggregation in the MS and the effects of adiponectin on platelet aggregation and activation. (cun.es)
  • The effects of adiponectin (APN) on tumor cells are not well understood, but a number of cancer epidemiologic studies have focused on APN as a predictive marker. (aacrjournals.org)
  • High concentrations of adiponectin were associated with a substantially reduced relative risk of type 2 diabetes after adjustment for age, sex, waist-to-hip ratio, body-mass index, smoking, exercise, alcohol consumption, education, and glycosylated haemoglobin A(1c) (odds ratio 4th vs 1st quartile 0.3 [95% CI 0.2-0.7], p=0.0051). (nih.gov)
  • 9 Similarly, it has been hypothesised that decreased serum concentrations of adiponectin observed in obese humans may also contribute to the propensity towards asthma in this population. (bmj.com)
  • In the present study we investigated effect of an α-glucosidase inhibitor, acarbose, together with pioglitazone, the only thiazolidine derivative available in Japan, on serum concentrations of adiponectin. (nii.ac.jp)
  • Plasma Concentrations of Adiponectin in Patients with Coronary Artery Disease and Coronary Slow Flow. (medworm.com)
  • In this issue of ATVB , Devaraj et al demonstrate that physiological concentrations of adiponectin suppress CRP synthesis and secretion in human aortic endothelial cells under hyperglycemic conditions. (ahajournals.org)
  • Adiponectin is a cytokine, "adipokine", produced almost exclusively in adipose tissue and is expressed at high levels by lean, healthy individuals. (hindawi.com)
  • We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic patients. (jci.org)
  • Adiponectin belongs to the adipokine family and initially was considered as a hormone produced exclusively by the white adipose tissue (WAT) [ 2 - 5 ]. (hindawi.com)
  • 17 ] identified the fourth fraction of the adipokine, globular adiponectin, which is formed by the proteolytic cleavage of full-length hormone. (hindawi.com)
  • Adiponectin is an important adipokine involved in fat metabolism and insulin sensitivity. (abcam.com)
  • The association of murine asthma with adiposity may be mediated by adiponectin, an anti-inflammatory adipokine with reduced serum concentrations in obese subjects. (bmj.com)
  • Adiponectin is an anti-diabetic and anti-atherogenic adipokine that serves as a major determinant of insulin sensitivity. (nii.ac.jp)
  • Adiponectin is a major adipocyte-secreted adipokine abundantly present in the circulation as three distinct oligomeric complexes. (portlandpress.com)
  • Adiponectin is an adipokine that inhibits inflammation, oxidative stress and metabolic syndrome components, namely dyslipidaemia, high blood pressure and insulin resistance. (intechopen.com)
  • In contrast to existing data on serum adiponectin, this study assesses whether urinary adiponectin excretion might represent a more consistent vascular damage marker in type 2 diabetes. (diabetesjournals.org)
  • Total urinary adiponectin excretion rate was measured in 156 patients with type 2 diabetes who had a history of diabetic nephropathy and 40 healthy control subjects using enzyme-linked immunosorbent assay. (diabetesjournals.org)
  • Urinary adiponectin was significantly increased in type 2 diabetes (7.68 ± 14.26 vs. control subjects: 2.91 ± 3.85 μg/g creatinine, P = 0.008). (diabetesjournals.org)
  • We designed a nested case-control study to assess whether baseline adiponectin concentrations in plasma are independently associated with risk of type 2 diabetes. (nih.gov)
  • We conclude that adiponectin is independently associated with a reduced risk of type 2 diabetes in apparently healthy individuals. (nih.gov)
  • Decreased levels of adiponectin are associated with insulin resistance, whereas high levels of adiponectin are associated with reduced risk of type-2 diabetes. (abcam.com)
  • A recent genome-wide scan study mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome to chromosome 3q27, where the adiponectin gene is located. (diabetesjournals.org)
  • Here, we screened Japanese patients with type 2 diabetes and age- and BMI-matched nondiabetic control subjects for mutations in adiponectin gene. (diabetesjournals.org)
  • Our findings suggest that I164T mutation is associated with low plasma adiponectin concentration and type 2 diabetes. (diabetesjournals.org)
  • Furthermore, two groups independently reported that one of the quantitative trait loci affecting insulin resistance/metabolic syndrome ( 21 ) and type 2 diabetes ( 22 ) was mapped on chromosome 3q27, where the adiponectin gene is located. (diabetesjournals.org)
  • These findings suggest that the reduced net function of adiponectin might be associated with the development of insulin resistance and type 2 diabetes. (diabetesjournals.org)
  • In the present study, we screened 218 Japanese patients with type 2 diabetes for mutations in the adiponectin gene. (diabetesjournals.org)
  • The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). (harvard.edu)
  • Despite a close association between adiponectin and both hypertension and type 2 diabetes, the relationship between adiponectin and metabolic syndrome has not yet been well-investigated. (nii.ac.jp)
  • Of particular interest is that low adiponectin serum levels predict type 2 diabetes independent of other risk factors. (biovendor.com)
  • The purpose of this protocol is to measure and compare levels of the circulating protein adiponectin and adiponectin's association with insulin sensitivity in Mexican Americans and non-Latino white subjects. (clinicaltrials.gov)
  • The adipose-specific protein adiponectin has been recently discovered to improve insulin sensitivity. (ahajournals.org)
  • Research conducted by a team of Greek and American endocrinologists has revealed that too little of the metabolic protein adiponectin in the blood may increase the likelihood of thyroid cancer, while higher levels may entail a lower-than-average risk of the disease. (endocrineweb.com)
  • Focuses on the role of protein adiponectin for regulation of energy homeostasis. (encognitive.com)
  • In this review, we briefly discuss the key characteristics of this interesting but very complex molecule, highlight recent results in the context of its mechanism of action and summarise some of the key epidemiological data that helped establish adiponectin as a robust biomarker for insulin sensitivity, cardiovascular disease and many additional disease phenomena. (springer.com)
  • Since the first report of its discovery in the mid-1990s [ 1 ], adiponectin has been the focus of an increasing amount of research given its pleiotropic, beneficial effects on insulin sensitivity and systemic inflammation. (springer.com)
  • 1 ) studied the relationship of serum adiponectin concentrations with hepatic and peripheral insulin sensitivity, body fat distribution, and components of the metabolic syndrome in adolescents. (diabetesjournals.org)
  • the proinsulin-to-insulin ratio was adjusted for BMI but not for insulin sensitivity, it remains unclear whether the relationship with adiponectin simply reflects insulin sensitivity. (diabetesjournals.org)
  • 7 ). In multiple linear regression models, neither proinsulin-to-insulin ratio ( r = 0.03, P = 0.46) nor 30-min C-peptide plasma concentrations ( r = 0.01, P = 0.79) or ISI ( r = 0.01, P = 0.80) during the OGTT were associated with fasting plasma adiponectin concentrations after adjustment for age, sex, percentage body fat, and insulin sensitivity. (diabetesjournals.org)
  • Bacha F, Saad R, Gungor N, Arslanian SA: Adiponectin in youth: relationship to visceral adiposity, insulin sensitivity and β-cell function. (diabetesjournals.org)
  • we investigated the relationship between the proinsulin-to-insulin ratio and adiponectin after adjusting for insulin sensitivity per metabolically active fat-free mass. (diabetesjournals.org)
  • The partial correlation coefficient of adiponectin to the proinsulin-to-insulin ratio after controlling for insulin sensitivity was r = −0.24, two-tailed P = 0.12, and one-tailed P = 0.06. (diabetesjournals.org)
  • Serum levels of adiponectin correlate inversely with insulin sensitivity. (pnas.org)
  • Weight loss, caloric restriction, or thiazolidinedione treatment increase adiponectin levels in human ( 12 - 14 ) and mice ( 15 , 16 ), and this increase correlates with increased insulin sensitivity. (pnas.org)
  • 18 ) demonstrated that recombinant adiponectin could restore insulin sensitivity to insulin-resistant obese ( ob / ob ), diabetic ( db / db ), or lipoatrophic mice by increasing β-oxidation of fatty acids in muscle. (pnas.org)
  • In regression analysis, adipocyte size, adiponectin, and waist circumference were the factors most strongly associated with insulin sensitivity in PCOS (R2=0.681, P (wellnessresources.com)
  • Finally, administration of irbesartan to obese Zucker rats improved insulin sensitivity and attenuated adiponectin serum depletion. (ahajournals.org)
  • 6 Adiponectin has been shown to be a potent enhancer of insulin sensitivity. (ahajournals.org)
  • The paper noted that higher levels of adiponectin are associated with increased insulin sensitivity, while lower levels are typically linked with increased triglycerides, body fat percentage and body mass index. (endocrineweb.com)
  • At the moment, our data in pediatrics remain supportive of an important relationship between adiponectin and measures of β-cell function. (diabetesjournals.org)
  • Nevertheless, despite the well-established association of adiponectin with metabolic disorders and cardiovascular disease, very few studies address the relationship between adiponectin and hypertension at a mechanistic level. (health.am)
  • This study investigates the causal relationship between adiponectin levels and metabolic and reproductive functions in PCOS. (pnas.org)
  • Published ahead of print in the online version of the Journal of Clinical Endocrinology and Metabolism (JCEM) , the study seems to confirm what has already been established for several other forms of carcinoma - namely, the inverse relationship between adiponectin and cancer risk. (endocrineweb.com)
  • Like several prior investigations into the relationship between adiponectin and cancer growth, scientists then extracted thyroid carcinoma samples from participants in order to measure the effect of adding more of the protein to the cellular environment. (endocrineweb.com)
  • Transgenic mice with increased adiponectin show reduced adipocyte differentiation and increased energy expenditure associated with mitochondrial uncoupling. (wikipedia.org)
  • Adiponectin levels are significantly reduced in a variety of obese and insulin-resistant states in mice ( 5 ), monkeys ( 6 ), and humans ( 7 ). (pnas.org)
  • Furthermore, long-term administration of adiponectin to mice fed a high-fat diet caused profound weight loss by enhancing free fatty acid oxidation in muscles without affecting food intake. (pnas.org)
  • The expression of adiponectin and its receptors has been identified in the reproductive organs of many animals, including rats, mice, humans, and pigs [ 11 - 16 ], which indicates a potential involvement of this hormone in the reproductive system functions. (hindawi.com)
  • moreover, unlike their littermates, muscle-R1KO mice failed to show increased muscle AMPK phosphorylation in response to adiponectin. (sciencemag.org)
  • Consistent with the decrease in muscle mitochondria in the muscle-R1KO mice, adiponectin caused an increase in mitochondrial DNA in C2C12 myocytes. (sciencemag.org)
  • Overexpression of adiponectin can also decrease the systolic blood pressure in genetically obese KKAy mice. (health.am)
  • Thus, increased levels of adiponectin can prevent prepubertal androgen-induced metabolic dysfunction in dihydrotestosterone-exposed mice with PCOS-like traits. (pnas.org)
  • Prepubertal mice overexpressing adiponectin from adipose tissue (APNtg), adiponectin knockouts (APNko), and their wild-type (WT) littermate mice were continuously exposed to placebo or dihydrotestosterone (DHT) to induce PCOS-like traits. (pnas.org)
  • Disruption of adiponectin in mice causes insulin resistance and neointimal formation. (peprotech.com)
  • Adiponectin regulates albuminuria and podocyte function in mice. (peprotech.com)
  • Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. (thermofisher.com)
  • In experimental mice, adiponectin inhibits endothelial cell proliferation and migration, primary tumor growth, and reduces atherosclerosis. (frontiersin.org)
  • We hypothesized that transgenic overexpression of adiponectin would attenuate allergic airways inflammation and mucous hyperplasia in mice. (harvard.edu)
  • To test this hypothesis, we used mice overexpressing adiponectin (Adipo Tg). (harvard.edu)
  • Adipo Tg mice had marked increases in both serum adiponectin and bronchoalveolar lavage (BAL) fluid adiponectin. (harvard.edu)
  • Results: The numbers of colon polyps were significantly increased in adiponectin-deficient mice compared with wild-type mice fed a high-fat diet. (ebscohost.com)
  • However, no difference was observed between wild-type and adiponectin- deficient mice fed a basal diet. (ebscohost.com)
  • Western blot analysis revealed activation of mammalian target of rapamycin, p70 S6 kinase, S6 protein and inactivation of AMP-activated protein kinase in the colon epithelium of adiponectin-deficient mice fed with high-fat diet. (ebscohost.com)
  • Adiponectin KO mice show increased pathology in a mouse model of IA. (jimmunol.org)
  • In this study, we observed that mortality, fungal burden, and tissue histopathology were increased in adiponectin-deficient mice in a neutropenic model of invasive aspergillosis. (jimmunol.org)
  • Lung RNA sequencing, quantitative RT-PCR, and subsequent pathway analysis demonstrated activation of inflammatory cytokine pathways with upstream regulation by IL-1 and TNF in adiponectin-deficient mice with decreased/inhibited anti-inflammatory genes/pathways, suggesting broad cytokine-mediated pathology along with ineffective fungal clearance. (jimmunol.org)
  • Quantitative RT-PCR analysis confirmed increased transcription of IL-1a, IL-6, IL-12b, IL-17A/F, and TNF in adiponectin-deficient mice at early time points postinfection, with a specific increase in intracellular TNF in alveolar macrophages. (jimmunol.org)
  • Although eosinophil recruitment and activation were increased in adiponectin-deficient mice, mortality was delayed, but not decreased, in mice deficient in both adiponectin and eosinophils. (jimmunol.org)
  • Interestingly, neutrophil depletion was required for increased inflammation in adiponectin-deficient mice in response to swollen/fixed conidia, suggesting that immune suppression enhances detrimental inflammation, whereas invasive fungal growth is dispensable. (jimmunol.org)
  • Plasma adiponectin concentrations were reduced in adult eNOS -/- mice compared with age-matched wild-type mice. (scialert.net)
  • Rosiglitazone-induced increases in adiponectin expression and mitochondrial content were also reduced significantly in eNOS -/- mice. (scialert.net)
  • Chronic administration of a NO donor reversed mitochondrial abnormalities and increased adiponectin expression in adipose tissue of eNOS -/- mice. (scialert.net)
  • In healthy adults, adiponectin circulates in serum at a high concentration (1.9-17.0 μg/ml). (pnas.org)
  • Hypoadiponectinemia is closely associated with the clinical phenotype of the metabolic syndrome and measuring the plasma concentration of adiponectin may be useful for management of the metabolic syndrome. (nih.gov)
  • Despite the fact that adiponectin is produced mainly by the WAT, its serum concentration is reversely correlated with the body mass index and the overall mass of WAT [ 18 ]. (hindawi.com)
  • Adiponectin plasma concentration was found to be sex dependent. (hindawi.com)
  • The present study aimed to analyze the effects of dietary components on gene expression and plasma concentration of adiponectin. (isciii.es)
  • To detect Human Adiponectin by sandwich ELISA (using 100μl/well) a concentration of 0.25-1.0 μg/ml of this antibody is required. (peprotech.com)
  • To detect Human Adiponectin by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/ml. (peprotech.com)
  • A study was undertaken to examine whether the serum adiponectin concentration is associated with human asthma and whether it explains the association between adiposity and asthma, particularly in women and in premenopausal women. (bmj.com)
  • The prevalence of current asthma in premenopausal women was reduced in the highest compared with the lowest tertile of serum adiponectin concentration (OR 0.46, 95% CI 0.26 to 0.84, p = 0.03), after adjusting for BMI. (bmj.com)
  • However, the interaction between serum adiponectin concentration and BMI category on current asthma status was not significant in premenopausal women or women overall. (bmj.com)
  • A high serum adiponectin concentration may protect against current asthma in premenopausal women but does not explain the association between asthma and adiposity. (bmj.com)
  • There was a positive association between serum adiponectin and adipose tissue oleic acid, while palmitoleic acid was negatively associated with adiponectin expression and positively correlated with insulin concentration. (biomedsearch.com)
  • For the first time, positive relationships are reported between the proportion of n-6 polyunsaturated fatty acids (PUFA) in adipose tissue and adiponectin concentration and expression. (biomedsearch.com)
  • The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. (dovepress.com)
  • The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group ( P =0.20). (dovepress.com)
  • METHODS AND RESULTS: Plasma adiponectin concentration was assessed by radioimmunoassay, and body mass index (BMI) was measured in 275 patients (138 women and 137 men). (biomedsearch.com)
  • The plasma adiponectin concentration of the hypertensive group was significantly lower than that of the non-hypertensive group (9.9 +/- 9.8 microg/ml vs. 12.9 +/- 9.5 microg/ml, p = 0.019). (biomedsearch.com)
  • CONCLUSION: The results suggest that a decrease in plasma adiponectin concentration is associated with the progression of left ventricular hypertrophy with diastolic dysfunction. (biomedsearch.com)
  • In this study we investigate the plasma concentration of adiponectin in patients with coronary artery disease (CAD), those with coronary slow flow (CSF) and in healthy subjects. (medworm.com)
  • The plasma concentration of adiponectin was measured using enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's specifications. (medworm.com)
  • T]‎ genotypes and investigate the association between the two SNPs and adiponectin concentration, metabolic parameters and risk of T2DM in the Bahraini population. (who.int)
  • A significant association exists between EAT thickness and both metabolic syndrome components and adiponectin concentration, a link that might be used as a biomarker for this disease. (scielo.br)
  • The hormone plays pleiotropic roles in the organism, but the most important function of adiponectin is the control of energy metabolism. (hindawi.com)
  • Systemic immunity and metabolism are coregulated by soluble factors, including the insulin-regulating adipose tissue cytokine adiponectin. (jimmunol.org)
  • Based on many reference data, it seems that adiponectin may be a link connecting the metabolism of adipose tissue and bone tissue. (springer.com)
  • We investigated if hyperglycemia affected photoreceptor metabolism to inhibit neurovascular development, and if adiponectin (APN) restored retinal metabolism to prevent ROP. (arvojournals.org)
  • Adiponectin is a 30-kDa adipocyte-derived vasoactive peptide closely linked to components of the metabolic syndrome (rev. in 12 ). (diabetesjournals.org)
  • Adiponectin as a biomarker of the metabolic syndrome. (nih.gov)
  • Ferritin was increased and adiponectin was decreased in type 2 diabetic and in obese diabetic subjects compared with those in equally obese individuals without metabolic syndrome. (jci.org)
  • TY - JOUR T1 - Adiponectin and metabolic syndrome in middle-aged and elderly Chinese. (unboundmedicine.com)
  • Accumulating experimental evidence indicates that adiponectin possesses anti-atherogenic, anti-inflammatory and anti-diabetic properties and may also participate importantly in the mechanism of metabolic syndrome and other diseases. (portlandpress.com)
  • Enhanced platelet aggregation and activation markers are found in the metabolic syndrome associated to low adiponectin concentrations. (cun.es)
  • To examine and evaluate the association between serum adiponectin levels and metabolic syndrome based on Japanese diagnostic criteria, we analyzed adiponectin and anthropometric parameters in 869 male employees aged 40-59 who belonged to a health insurance society in Fukuoka Prefecture and who underwent annual health check-ups from August 2006 to July 2007. (nii.ac.jp)
  • The serum adiponectin levels were significantly higher in the non-metabolic syndrome group. (nii.ac.jp)
  • In a multiple logistic regression analysis, the subjects in the top quartile of serum adiponectin (adjusted odds ratio:0.36;95% confidence interval:0.21-0.63) and the second (adjusted odds ratio:0.51;95% confidence interval:0.31-0.84) quartile had a significantly decreased risk for metabolic syndrome in comparison to the bottom quartile. (nii.ac.jp)
  • The dose-response relationship between serum adiponectin levels and metabolic syndrome was significant (p for trend 0.0001) after adjusting for age, body mass index, smoking status, and drinking status. (nii.ac.jp)
  • Thirty-one patients diagnosed with metabolic syndrome (study group) and 27 controls were selected and tested for glycemia, lipids, and adiponectin. (scielo.br)
  • We found that iron negatively regulated adiponectin transcription via FOXO1-mediated repression. (jci.org)
  • Adiponectin is negatively associated with MetS in the middle-aged and elderly Chinese independent of known confounders such as BMI, physical activity and life habits. (unboundmedicine.com)
  • 7 Moreover, we recently found that C-reactive protein levels are negatively correlated with adiponectin levels in both human plasma and adipose tissue. (ahajournals.org)
  • However, coronary artery disease has been found to be positively associated with high molecular weight adiponectin, but not with low molecular weight adiponectin. (wikipedia.org)
  • However, it has been reported that in pathological conditions such as coronary artery disease (CAD), diabetes mellitus, and hypertension that adiponectin levels decline [ 1 - 4 ]. (hindawi.com)
  • Diabetic humans with coronary artery disease have even lower plasma levels of adiponectin than those without ( 8 ). (pnas.org)
  • Low serum adiponectin levels are found in patients with coronary artery disease. (biovendor.com)
  • Our results suggest that adiponectin inhibits excessive lung inflammation in invasive aspergillosis. (jimmunol.org)
  • Although adiponectin inhibits proliferation and metastasis of breast cancer cells, the underlying molecular mechanisms remain obscure. (aacrjournals.org)
  • 13 This regulation of adiponectin results, at least in part, from the upregulation of tumor necrosis factor (TNF)-α and other proinflammatory cytokines which inhibits the synthesis of adiponectin in the obese state. (ahajournals.org)
  • 14 A series of in vitro experiments have demonstrated that adiponectin inhibits the production and action of TNFα, a key proinflammatory cytokine, in various types of cells including cardiac and vascular cells. (ahajournals.org)
  • Devaraj et al demonstrate that adiponectin inhibits CRP production 16 in endothelial cells through its ability to modulate the AMP-kinase (AMPK) signaling pathways ( Figure ). (ahajournals.org)
  • Novel evidence is provided demonstrating that adiponectin has anti-thrombotic properties, since it inhibits platelet aggregation and platelet activation. (cun.es)
  • Adiponectin also inhibits the inflammatory processes of atherosclerosis suppressing the expression of adhesion and cytokine molecules in vascular endothelial cells and macrophages, respectively. (biovendor.com)
  • In humans, normal-range serum ferritin levels were inversely associated with adiponectin, independent of inflammation. (jci.org)
  • Adiponectin may thus attenuate inflammation associated with atherogenesis. (prospecbio.com)
  • This study identified, for the first time, the adiponectin/IL-10 interaction against vascular inflammation. (ahajournals.org)
  • In obese subjects, adiponectin levels are decreased, and the ability of adiponectin to inhibit the inflammatory processes is limited. (hindawi.com)
  • Obese patients, particularly those with visceral fat accumulation, have reduced plasma levels of adiponectin, the most abundant and adipose-specific adipocytokine. (portlandpress.com)
  • Obese individuals have decreased circulating adiponectin, an adipose-derived hormone with anti-inflammatory properties. (harvard.edu)
  • Whereas adiponectin is expressed almost exclusively in adipose tissue, 11,12 plasma adiponectin levels are paradoxically decreased in obese individuals. (ahajournals.org)
  • Adiponectin is the hormone that belongs to the group of adipokines, chemical agents mainly derived from the white adipose tissue. (hindawi.com)
  • The adipose tissue participates in the regulation of energy homeostasis as an important endocrine organ that secretes a number of biologically active adipokines, including adiponectin. (frontiersin.org)
  • Metabolically, one of the more important fat-derived factors ("adipokines") is adiponectin (APN). (aacrjournals.org)
  • We evaluated the association of adiponectin with the occurrence of breast cancer in a case-control study comprising 174 women with newly diagnosed, histologically confirmed breast cancer and 167 controls. (nih.gov)
  • Cognate mRNA levels of adiponectin were not affected by ARBs. (ahajournals.org)
  • Messenger RNA (mRNA) levels of adiponectin and PPARγ were measured by using reverse-transcription and quantitative real-time polymerase chain reaction. (aappublications.org)
  • Adiponectin treatment dose-dependently increased TIMP-1 mRNA levels without affecting MMP-9 mRNA levels. (ahajournals.org)
  • Time course experiments indicated that TIMP-1 mRNA levels started to increase at 24 hours of adiponectin treatment and were significantly elevated at 48 hours. (ahajournals.org)
  • 14 In addition, it has been shown that CRP is also produced in adipose tissues and that a significant negative relationship is found between CRP and adiponectin mRNA levels in adipose tissues. (ahajournals.org)
  • Adiponectin, an adipocyte-secreted hormone, is closely and inversely associated with insulin resistance and was recently found to be inversely and independently associated with endometrial cancer. (nih.gov)
  • The "adiponectin theory" is still controversial, notes David Bell, MD , of the University of Alabama at Birmingham, but a statin-induced reduction in the hormone may lead to both islet cell dysfunction and insulin resistance. (medpagetoday.com)
  • The only hormone displaying an opposite trend is adiponectin. (health.am)
  • Decrease in adiponectin levels correlates to growth response in growth hormone-treated children. (gu.se)
  • The aim of this study was to investigate whether changes in serum adiponectin levels are related to the growth response, insulin levels and insulin resistance during growth hormone (GH) treatment. (gu.se)
  • Adiponectin, an adipocyte-derived hormone, together with adipocyte size, is the strongest factor associated with insulin resistance in PCOS. (pnas.org)
  • In women with PCOS, adipose tissue produces less of the "good" hormone adiponectin which increases the body's sensitivity to insulin. (wellnessresources.com)
  • Adiponectin, produced in adipose tissues of mammals, is an insulin-sensitizing hormone. (frontiersin.org)
  • Strangely, osmotin acts like the mammalian hormone adiponectin in various in vitro and in vivo models. (frontiersin.org)
  • Adiponectin, the insulin sensitizing mammalian hormone is secreted in adipose tissues and exerts its function by binding to the plasma membrane receptors called as adiponectin receptors (AdipoRs). (frontiersin.org)
  • This observation is surprising, given that adiponectin is produced by adipose tissue. (wikipedia.org)
  • Mutations and polymorphisms in the adiponectin gene are associated with reduced serum levels of adiponectin, in part due to effects on protein secretion, multimerization, and/or stability ( 9 - 11 ). (pnas.org)
  • Increased serum levels of adiponectin and expression of its receptors on lung tissues of COPD patients have recently highlighted the importance of the adiponectin pathway in this disease. (mdpi.com)
  • In summary, adiponectin expression and serum levels are associated with fatty acid composition, with SFA, trans and palmitoleic fatty acids appearing as negative markers for adiponectin, and oleic acid and n-6 PUFA as positive ones. (biomedsearch.com)
  • Pioglitazone, as expected, increased serum levels of total adiponectin by 2.1 fold and its high molecular weight isoform by 3.6 fold. (nii.ac.jp)
  • Low serum levels of adiponectin are a high risk factor for various types of cancer. (aacrjournals.org)
  • In humans, the consumption of a healthy and Mediterranean diet are positively associated with adiponectin levels, although the mechanisms are not fully understood. (isciii.es)
  • Our results suggest that there exists no increased risk for atherosclerotic cardiovascular disease associated with adiponectin levels and insulin resistance in patients with Behçet's disease. (wiley.com)
  • Adiponectin exerts some of its weight reduction effects via the brain. (wikipedia.org)
  • Adiponectin also exerts anti-hypertrophic effects and protects against ischemia-reperfusion injury [ 16 , 17 ]. (hindawi.com)
  • Adiponectin (APN) is an adipose-derived plasma protein, which exerts anti-inflammatory and anti-hypertrophic effects. (ahajournals.org)
  • Adiponectin exerts its vasculoprotective effects through its direct actions in the vascular system, such as increasing endothelial NO production, inhibiting endothelial cell activation and endothelium-leucocyte interaction, enhancing phagocytosis, and suppressing macrophage activation, macrophage-to-foam cell transformation and platelet aggregation. (portlandpress.com)
  • The entire coding regions of the adiponectin gene were amplified from the genomic DNA and directly sequenced. (diabetesjournals.org)
  • We have previously identified two different mutations of the adiponectin gene, including the R112C missense mutation and the G/T polymorphism at nucleotide 94 ( 23 ). (diabetesjournals.org)
  • The human Adiponectin gene spans 17 kb on chromosome 3q27 (Saito et al, 1999), consisting of three exons and two introns. (prospecbio.com)
  • Mutations in this gene are associated with adiponectin deficiency. (origene.com)
  • The results in animal models demonstrate that the consumption of hyperlipidemic diets, rich in saturated fat, reduces the levels of adiponectin, while the diets rich in polyunsaturated fatty acids and supplementation with omega-3 and eicosapentaenoic acid increase its gene expression and plasma levels. (isciii.es)
  • Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. (peprotech.com)
  • The aims of the present study were to investigate the association between adiponectin gene polymorphisms and the response to rosiglitazone monotherapy in T2D patients. (clinicaltrials.gov)
  • In serum, insulin (radioimmunoassay) and adiponectin levels (enzyme-linked immunosorbent assay) were also measured, while adiponectin gene expression was analysed (real time-qPCR) in all fat depots. (biomedsearch.com)
  • The close association between adiponectin and PPARγ expression supports the hypothesis that PPARγ is involved in adiponectin gene regulation. (aappublications.org)
  • Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. (dovepress.com)
  • Adiponectin gene polymorphisms (T45G and G276T), adiponectin levels and risk for metabolic diseases in an Arab population. (springer.com)
  • A novel variant in the ARL15 (ADP-ribosylation factor-like 15) gene was associated with lower circulating levels of adiponectin (rs4311394-G, P-combined = 2.9×10−8, n = 14,733). (harvard.edu)
  • RESULTS A homogenous staining of adiponectin was found on the endothelial surface of glomerular capillaries and intrarenal arterioles in nondiabetic kidneys, whereas staining was decreased in diabetic nephropathy. (diabetesjournals.org)
  • Ouchi et al (1999) have determined that adiponectin suppresses TNF induced adhesion of monocytes to aortic endothelial cells and also suppresses the expression of vascular cell adhesion molecule 1 (VCAM-1), selectin E, and intercellular adhesion molecule 1 (ICAM-1 (CD54)) in these cells. (prospecbio.com)
  • 2 We have reported that physiological concentrations of human recombinant adiponectin suppressed tumor necrosis factor-α (TNF-α)-induced endothelial adhesion molecule expression, transformation from macrophage to foam cell, and TNF-α expression in macrophages. (ahajournals.org)
  • Numerous epidemiological studies based on different ethnic groups have identified adiponectin deficiency (hypoadiponectinaemia) as an independent risk factor for endothelial dysfunction, hypertension, coronary heart disease, myocardial infarction and other cardiovascular complications. (portlandpress.com)
  • 16 These findings are consistent with previous studies showing that adiponectin attenuates TNF-α-induced NF-κB activation in endothelial cells, resulting in reduced expression of cell adhesion molecules and interleukin (IL)-8. (ahajournals.org)
  • 21 Adiponectin activates AMPK signaling in hepatocytes, myocytes, and endothelial cells, and this increase in AMPK signaling is believed to contribute to the insulin-sensitizing and cardioprotective actions of adiponectin. (ahajournals.org)
  • In all, the group exposed 40 cell samples (mainly papillary and follicular, but including one sample each of medullary and anaplastic thyroid cancer) to recombinant adiponectin in test tubes. (endocrineweb.com)
  • Recombinant adiponectin did not exert a clinically significant direct effect on cell cycle, proliferation, or apoptosis in thyroid cancer cell lines in vitro,' the authors wrote. (endocrineweb.com)
  • Methods and Results- Human monocyte-derived macrophages were incubated with the physiological concentrations of human recombinant adiponectin for the time indicated. (ahajournals.org)
  • whereas low-circulating adiponectin was significantly associated with increased primary CVD risk in apparently healthy men ( 8 ), subsequent studies in high-risk populations, as well as patients with prevalent coronary heart disease (CHD), failed to confirm this association ( 9 , 10 ). (diabetesjournals.org)
  • On a high-salt diet, Ohashi et al showed that adiponectin-deficient animals display significantly higher systolic blood pressure compared with wild-type control animals independent of insulin resistance. (health.am)
  • The participants in the lowest adiponectin quartile had a significantly increased risk for acquiring MetS (odds ratio (OR) 3.38, 95% confidence interval (CI) 2.56-4.46) after adjustment for potential confounders. (unboundmedicine.com)
  • Plasma levels of adiponectin (APN) are significantly increased in patients with renal dysfunction and are inversely related to the risk of cardiovascular mortality. (sigmaaldrich.com)
  • Adiponectin significantly increased interleukin-10 (IL-10) mRNA expression at the transcriptional level within 6 hours and significantly increased IL-10 protein secretion within 24 hours. (ahajournals.org)
  • The adiponectin monomer (30 kDa) has a structure consisting of a globular head and a collagenous tail, and this monomer is able to multimerize to form several stable complexes of low-, medium-, and high-molecular weight. (hindawi.com)
  • Adiponectin is composed of four distinct domains: a signal peptide at the N terminus, a short variable region, a collagenous domain, and a C-terminal globular domain homologous to C1q. (pnas.org)
  • The crystal structure of adiponectin globular domain reveals a striking resemblance to the structure of tumor necrosis factor (TNF)-α ( 3 ). (pnas.org)
  • Adiponectin belongs to a growing family of proteins, all of which contain a C-terminal globular C1q-like domain of ≈135 aa. (pnas.org)
  • Differences in activity initially attributed to full-length or globular adiponectin can be ascribed to the different oligomeric forms of adiponectin ( 11 , 21 - 23 ). (pnas.org)
  • Adiponectin possesses a signal sequence at the NH 2 -terminal end and is composed of the collagen repeats domain and the COOH-terminal globular domain ( 10 , 14 ). (diabetesjournals.org)
  • gAcrp30 globular protein, exists as a result of proteolytic processing of adiponectin. (prospecbio.com)
  • Detects an epitope in the globular domain (aa 104 - 244) of human Adiponectin. (rndsystems.com)
  • Human recombinant globular domain of adiponectin (gAd) or full-length adiponectin (fAd) was administered via intraperitoneal injection once daily for 7 consecutive days after SN, and in vivo MI/R was introduced 3 wk later. (sigmaaldrich.com)
  • We describe a widely expressed and highly conserved family of adiponectin paralogs designated as C1q/tumor necrosis factor-α-related proteins (CTRPs) 1-7. (pnas.org)
  • Including the seven adiponectin paralogs described here, there are currently 25 proteins belonging to the C1q/TNF-α superfamily. (pnas.org)
  • In the serum, adiponectin occurs at approximately 0.01% of total plasma proteins, at the μ g/ml concentrations [ 18 ]. (hindawi.com)
  • The collagen domain allows adiponectin to form trimers, hexamers, and higher order complexes prior to being secreted. (springer.com)
  • Another designation is ACDC [adiponectin, C1q and collagen domain containing]. (prospecbio.com)
  • Adiponectin is a secreted protein of 244 amino acids that belongs to a protein family possessing a collagen-like domain through which they form homo-trimers, which further combine to make oligomeric complexes (Tsao et al, 2002). (prospecbio.com)
  • Adiponectin specifically binds to collagen type 1, collagen type 3 and collagen type 5, which are present in vascular intima. (prospecbio.com)
  • Hydroxylation and glycosylation of the lysine residues within the collagene-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes. (abcam.com)
  • Insulin stimulates the secretion of adiponectin. (abcam.com)
  • Recently, adiponectin was found to enhance exosome biogenesis and secretion, leading to a decrease in cellular ceramides, excess of which is known to cause insulin resistance and cardiovascular disease phenotypes. (jci.org)
  • Adiponectin also augmented TIMP-1 secretion into the media, whereas MMP-9 secretion and activity were unchanged. (ahajournals.org)
  • 17,18 Adiponectin has also been shown to inhibit agonist-stimulated NF-κB signaling and suppress TNF-α secretion from a number of cell types including macrophages. (ahajournals.org)
  • Anti-Human Adiponectin-specific antibody was purified by affinity chromatography and then biotinylated. (peprotech.com)
  • This biotinylated polyclonal antibody, in conjunction with PeproTech's Polyclonal Anti-Human Adiponectin (500-P239) as a capture antibody, allows the detection of at least 2000-4000 pg/ml of Recombinant Human Adiponectin. (peprotech.com)
  • Western Blot: Adiponectin Antibody (1B2) [NBP2-01399] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Adiponectin (Right lane) cDNA for 48 hrs and lysed. (novusbio.com)
  • Immunocytochemistry/ Immunofluorescence: Adiponectin Antibody (1B2) [NBP2-01399] Staining of COS7 cells transiently transfected by pCMV6-ENTRY Adiponectin. (novusbio.com)
  • Immunohistochemistry-Paraffin: Adiponectin Antibody (1B2) [NBP2-01399] - Staining of paraffin-embedded Human Kidney tissue using anti-Adiponectin mouse monoclonal antibody. (novusbio.com)
  • In ELISAs, this antibody shows no cross-reactivity or interference with recombinant mouse (rm) Adiponectin or rh6Ckine. (rndsystems.com)
  • Adiponectin antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human adiponectin. (genetex.com)
  • Western blot analysis of adiponectin in rat brain cell lysate with adiponectin antibody at (A) 1, (B) 2, and (C) 4 ug/mL. (genetex.com)
  • Immunohistochemistry of adiponectin in rat brain tissue with adiponectin antibody at 1 ug/mL. (genetex.com)
  • Cotreatment of adiponectin with anti-IL-10 monoclonal antibody completely abolished adiponectin-induced TIMP-1 mRNA expression. (ahajournals.org)
  • In addition to promoting adipocyte differentiation, PPAR- γ agonists are known to increase adiponectin expression both in vitro and in vivo [ 9 ]. (hindawi.com)
  • Eicosapentaenoic acid and docosahexaenoic acid supplementation may increase adiponectin and reduce TNF-α levels. (greenmedinfo.com)
  • Humans with lower levels of adiponectin have reduced cognitive function. (wikipedia.org)
  • Noting that adiponectin deficiency promotes insulin resistance and that insulin resistance is associated with mitochondrial dysfunction, Iwabu et al . (sciencemag.org)
  • We investigated the effect of adiponectin deficiency on the development of colorectal cancer. (ebscohost.com)
  • Increased myocardial ischemia-reperfusion injury in renal failure involves cardiac adiponectin signal deficiency. (sigmaaldrich.com)
  • Many studies have found adiponectin to be inversely correlated with body mass index in patient populations. (wikipedia.org)
  • Plasma adiponectin levels are inversely correlated with the severity of insulin resistance. (diabetesjournals.org)
  • Higher platelet aggregation was found in the MS. Adiponectin inversely correlated with P-selectin (R:-0.35, p:0.009), sCD40L (R:-0.24, p:0.05) and epinephrine and collageninduced aggregation (r=-0.80, p=0.005 and r=-0.70, p=0.011). (cun.es)
  • Paradoxically, adipose tissue-expressed adiponectin levels are inversely related to the degree of adiposity. (biovendor.com)
  • can partially mimic adiponectin action and induce AMPK (5′ adenosine monophosphate-activated protein kinase) signaling in cancer tissues, specific, and selective compounds targeting AdipoR were not available before 2011. (frontiersin.org)
  • In this study, we show that adiponectin-activated AMPK reduces the invasiveness of MDA-MB-231 cells by stimulating dephosphorylation of AKT by increasing protein phosphatase 2A (PP2A) activity. (aacrjournals.org)
  • In this study, we examine the ability of AMPK, activated by adiponectin to activate PP2A by phosphorylation of its B56 subunit, which in turn suppresses invasiveness by inactivating AKT. (aacrjournals.org)
  • Specifically they show that AMPK inhibition attenuates the ability of adiponectin to suppress NF-κB activity and CRP production. (ahajournals.org)
  • Adiponectin is an adipocyte-derived peptide, which has anti-inflammatory and insulin-sensitising properties. (nih.gov)
  • Studies have shown that adiponectin administration in humans and rodents has insulin-sensitizing, anti-atherogenic, and anti-inflammatory effects, and, in certain settings, also decreases body weight. (mdpi.com)
  • Among these, adiponectin (APN) has been reported as a major anti-inflammatory mediator inhibiting the development of cardiovascular disease ( 3 , 4 ). (spandidos-publications.com)
  • Human Adiponectin ELISA Kit (ab222508) is a single-wash 90 min sandwich ELISA designed for the quantitative measurement of Adiponectin protein in cit plasma, edta plasma, hep plasma, and serum. (abcam.com)
  • The Quantikine Mouse Adiponectin Immunoassay is a 4.5 hour solid phase ELISA designed to measure full-length mouse Adiponectin levels in cell culture supernates, tissue homogenates, serum, and plasma. (rndsystems.com)
  • Due to the importance of adiponectin in preventing metabolic diseases and reducing cardiovascular risk, more research are needed on food strategies to promote the increase of adiponectin levels. (isciii.es)
  • Debido a la importancia de la adiponectina en la prevención de las enfermedades metabólicas y la reducción de riesgo cardiovascular, más investigaciones son necesarias sobre las estrategias alimentarias para promover el aumento de los niveles de adiponectina. (isciii.es)
  • The aim of our study was to investigate insulin resistance and serum adiponectin levels as cardiovascular risk markers in patients with Behçet's disease. (wiley.com)
  • Clinically, high plasma adiponectin level was associated with low cardiovascular event rate in patients with chronic renal failure. (ahajournals.org)
  • 5,6 Plasma adiponectin levels are an inverse predictor of cardiovascular outcomes among patients with end-stage renal disease. (ahajournals.org)
  • Gender difference in adiponectin associated with cardiovascular mortality. (springer.com)
  • We previously reported that adiponectin, an adipose-specific plasma protein, accumulated to the injured artery and attenuated vascular inflammatory response. (ahajournals.org)
  • Conclusions: Adiponectin suppresses colonic epithelial proliferation via inhibition of the mammalian target of the rapamycin pathway under a high-fat diet, but not under a basal diet. (ebscohost.com)
  • Our study has therefore identified the adiponectin pathway as a potential source for novel therapeutics in immune-compromised patients with detrimental immunity to invasive fungal infection. (jimmunol.org)
  • Mechanistic studies revealed that HIF1α suppressed the expression of adiponectin through a SOCS3-STAT3 pathway. (sigmaaldrich.com)
  • In vivo, ACF also regulated the SOCS3-STAT3-adiponectin pathway, and inhibition of HIF1α in adipose tissue was essential for ACF to improve the SOCS3-STAT3-adiponectin pathway to counteract insulin resistance. (sigmaaldrich.com)
  • Considering these structural features of ADP355 and the fact that adiponectin normally circulates as multimeric complexes, we developed and tested the activity of a linear branched dimer (ADP399). (frontiersin.org)
  • The fact that adiponectin expression was decreased in omental adipose tissue relative to subcutaneous adipose tissue in overweight children suggests that a risk of insulin resistance may be present in childhood, which allows such resistance to develop after a relatively short duration of overweight. (aappublications.org)
  • However, it is not readily obvious that the correlations of serum adiponectin with fasting serum proinsulin and serum proinsulin-to-insulin ratio indicate a direct effect of adiponectin on insulin secretory function in vivo. (diabetesjournals.org)
  • We never implied that a direct effect of adiponectin on insulin secretory function exists. (diabetesjournals.org)
  • Background and aims: The effect of adiponectin on colorectal carcinogenesis has been proposed but not fully investigated. (ebscohost.com)
  • Platelets express the receptors for adiponectin. (cun.es)
  • Kharroubi I, Rasschaert J, Eizirik DL, Cnop M: Expression of adiponectin receptors in pancreatic beta cells. (diabetesjournals.org)
  • In addition, administration of adiponectin to β-cells seems to inhibit palmitic acid-induced apoptosis ( 3 ). (diabetesjournals.org)
  • We also show that both the blood levels of adiponectin and the tissue levels of PP2A activity were decreased in breast cancer patients and that the direct administration of adiponectin into tumor tissues stimulates PP2A activity. (aacrjournals.org)