A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.
Cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin.
Intercellular Signaling Peptides and Proteins
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Body Mass Index
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Metabolic Syndrome X
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
AMP-Activated Protein Kinases
Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Glucose Tolerance Test
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Adipose Tissue, White
The waist circumference measurement divided by the hip circumference measurement. For both men and women, a waist-to-hip ratio (WHR) of 1.0 or higher is considered "at risk" for undesirable health consequences, such as heart disease and ailments associated with OVERWEIGHT. A healthy WHR is 0.90 or less for men, and 0.80 or less for women. (National Center for Chronic Disease Prevention and Health Promotion, 2004)
Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity. (1/2639)Obesity which is defined as accumulation of excess body fat, is a major cause of atherosclerotic vascular disease in industrial countries. Recent advances in the biology of adipose tissue have revealed that adipose tissue is not simply an energy storage organ but it also secretes a variety of molecules which affect the metabolism of the whole body. Through a systematic search of active genes in adipose tissue, we found that adipose tissue, especially visceral fat expressed numerous genes for secretory proteins (about 30% of total genes analyzed). Among them, plasminogen activator-1 (PAI-1), which is a regulator of the fibrinolytic system, was overexpressed in the visceral fat in an animal model of obesity. Plasma levels of PAI-1 were closely correlated with visceral fat adiposity. Thus, PAI-1 secreted from visceral fat may play some role in thrombotic vascular disease in visceral obesity. Adiponectin, a novel adipose-specific gene product, which has a matrix-like structure, is abundantly present in the bloodstream. Dysregulated secretion of adiponectin may be related to vascular disease in obesity. Biologically active molecules secreted from adipose tissue (adipocytokines) may have important roles in the development of atherosclerotic disease in obesity. (+info)
Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. (2/2639)Insulin stimulates adipose cells both to secrete proteins and to translocate the GLUT4 glucose transporter from an intracellular compartment to the plasma membrane. We demonstrate that whereas insulin stimulation of 3T3-L1 adipocytes has no effect on secretion of the alpha3 chain of type VI collagen, secretion of the protein hormone adipocyte complement related protein of 30 kD (ACRP30) is markedly enhanced. Like GLUT4, regulated exocytosis of ACRP30 appears to require phosphatidylinositol-3-kinase activity, since insulin-stimulated ACRP30 secretion is blocked by pharmacologic inhibitors of this enzyme. Thus, 3T3-L1 adipocytes possess a regulated secretory compartment containing ACRP30. Whether GLUT4 recycles to such a compartment has been controversial. We present deconvolution immunofluorescence microscopy data demonstrating that the subcellular distributions of ACRP30 and GLUT4 are distinct and nonoverlapping; in contrast, those of GLUT4 and the transferrin receptor overlap. Together with supporting evidence that GLUT4 does not recycle to a secretory compartment via the trans-Golgi network, we conclude that there are at least two compartments that undergo insulin-stimulated exocytosis in 3T3-L1 adipocytes: one for ACRP30 secretion and one for GLUT4 translocation. (+info)
Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. (3/2639)BACKGROUND: Among the many adipocyte-derived endocrine factors, we recently found an adipocyte-specific secretory protein, adiponectin, which was decreased in obesity. Although obesity is associated with increased cardiovascular mortality and morbidity, the molecular basis for the link between obesity and vascular disease has not been fully clarified. The present study investigated whether adiponectin could modulate endothelial function and relate to coronary disease. METHODS AND RESULTS: For the in vitro study, human aortic endothelial cells (HAECs) were preincubated for 18 hours with the indicated amount of adiponectin, then exposed to tumor necrosis factor-alpha (TNF-alpha) (10 U/mL) or vehicle for the times indicated. The adhesion of human monocytic cell line THP-1 cells to HAECs was determined by adhesion assay. The surface expression of vascular cell adhesion molecule-1 (VCAM-1), endothelial-leukocyte adhesion molecule-1 (E-selectin), and intracellular adhesion molecule-1 (ICAM-1) was measured by cell ELISA. Physiological concentrations of adiponectin dose-dependently inhibited TNF-alpha-induced THP-1 adhesion and expression of VCAM-1, E-selectin, and ICAM-1 on HAECs. For the in vivo study, the concentrations of adiponectin in human plasma were determined by a sandwich ELISA system that we recently developed. Plasma adiponectin concentrations were significantly lower in patients with coronary artery disease than those in age- and body mass index-adjusted control subjects. CONCLUSIONS: These observations suggest that adiponectin modulates endothelial inflammatory response and that the measurement of plasma adiponectin levels may be helpful in assessment of CAD risk. (+info)
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. (4/2639)Adiponectin is a novel, adipose-specific protein abundantly present in the circulation, and it has antiatherogenic properties. We analyzed the plasma adiponectin concentrations in age- and body mass index (BMI)-matched nondiabetic and type 2 diabetic subjects with and without coronary artery disease (CAD). Plasma levels of adiponectin in the diabetic subjects without CAD were lower than those in nondiabetic subjects (6.6+/-0.4 versus 7.9+/-0.5 microg/mL in men, 7.6+/-0.7 versus 11.7+/-1.0 microg/mL in women; P<0.001). The plasma adiponectin concentrations of diabetic patients with CAD were lower than those of diabetic patients without CAD (4.0+/-0.4 versus 6.6+/-0.4 microg/mL, P<0.001 in men; 6.3+/-0.8 versus 7.6+/-0. 7 microg/mL in women). In contrast, plasma levels of leptin did not differ between diabetic patients with and without CAD. The presence of microangiopathy did not affect the plasma adiponectin levels in diabetic patients. Significant, univariate, inverse correlations were observed between adiponectin levels and fasting plasma insulin (r=-0.18, P<0.01) and glucose (r=-0.26, P<0.001) levels. In multivariate analysis, plasma insulin did not independently affect the plasma adiponectin levels. BMI, serum triglyceride concentration, and the presence of diabetes or CAD remained significantly related to plasma adiponectin concentrations. Weight reduction significantly elevated plasma adiponectin levels in the diabetic subjects as well as the nondiabetic subjects. These results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy. (+info)
Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. (5/2639)We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses. Adiponectin suppressed colony formation from colony-forming units (CFU)-granulocyte-macrophage, CFU-macrophage, and CFU-granulocyte, whereas it had no effect on that of burst-forming units-erythroid or mixed erythroid-myeloid CFU. In addition, adiponectin inhibited proliferation of 4 of 9 myeloid cell lines but did not suppress proliferation of erythroid or lymphoid cell lines except for one cell line. These results suggest that adiponectin predominantly inhibits proliferation of myelomonocytic lineage cells. At least one mechanism of the growth inhibition is induction of apoptosis because treatment of acute myelomonocytic leukemia lines with adiponectin induced the appearance of subdiploid peaks and oligonucleosomal DNA fragmentation. Aside from inhibiting growth of myelomonocytic progenitors, adiponectin suppressed mature macrophage functions. Treatment of cultured macrophages with adiponectin significantly inhibited their phagocytic activity and their lipopolysaccharide-induced production of tumor necrosis factor alpha. Suppression of phagocytosis by adiponectin is mediated by one of the complement C1q receptors, C1qRp, because this function was completely abrogated by the addition of an anti-C1qRp monoclonal antibody. These observations suggest that adiponectin is an important negative regulator in hematopoiesis and immune systems and raise the possibility that it may be involved in ending inflammatory responses through its inhibitory functions. (Blood. 2000;96:1723-1732) (+info)
Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. (6/2639)BACKGROUND: Among the many adipocyte-derived endocrine factors, we found an adipocyte-derived plasma protein, adiponectin, that was decreased in obesity. We recently demonstrated that adiponectin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced expression of endothelial adhesion molecules and that plasma adiponectin level was reduced in patients with coronary artery disease (CIRCULATION: 1999;100:2473-2476). However, the intracellular signal by which adiponectin suppressed adhesion molecule expression was not elucidated. The present study investigated the mechanism of modulation for endothelial function by adiponectin. METHODS AND RESULTS: The interaction between adiponectin and human aortic endothelial cells (HAECs) was estimated by cell ELISA using biotinylated adiponectin. HAECs were preincubated for 18 hours with 50 microg/mL of adiponectin, then exposed to TNF-alpha (10 U/mL) or vehicle for the times indicated. NF-kappaB-DNA binding activity was determined by electrophoretic mobility shift assays. TNF-alpha-inducible phosphorylation signals were detected by immunoblotting. Adiponectin specifically bound to HAECs in a saturable manner and inhibited TNF-alpha-induced mRNA expression of monocyte adhesion molecules without affecting the interaction between TNF-alpha and its receptors. Adiponectin suppressed TNF-alpha-induced IkappaB-alpha phosphorylation and subsequent NF-kappaB activation without affecting other TNF-alpha-mediated phosphorylation signals, including Jun N-terminal kinase, p38 kinase, and Akt kinase. This inhibitory effect of adiponectin is accompanied by cAMP accumulation and is blocked by either adenylate cyclase inhibitor or protein kinase A (PKA) inhibitor. CONCLUSIONS: These observations raise the possibility that adiponectin, which is naturally present in the blood stream, modulates the inflammatory response of endothelial cells through cross talk between cAMP-PKA and NF-kappaB signaling pathways. (+info)
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. (7/2639)Adipocyte complement-related protein (30 kDa) (Acrp30), a secreted protein of unknown function, is exclusively expressed in differentiated adipocytes; its mRNA is decreased in obese humans and mice. Here we describe novel pharmacological properties of the protease-generated globular head domain of Acrp30 (gAcrp30). Acute treatment of mice with gAcrp30 significantly decreased the elevated levels of plasma free fatty acids caused either by administration of a high fat test meal or by i.v. injection of Intralipid. This effect of gAcrp30 was caused, at least in part, by an acute increase in fatty acid oxidation by muscle. As a result, daily administration of a very low dose of gAcrp30 to mice consuming a high-fat/sucrose diet caused profound and sustainable weight reduction without affecting food intake. Thus, gAcrp30 is a novel pharmacological compound that controls energy homeostasis and exerts its effect primarily at the peripheral level. (+info)
Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. (8/2639)BACKGROUND: Excessive lipid accumulation in macrophages plays an important role in the development of atherosclerosis. Recently, we discovered an adipocyte-specific plasma protein, adiponectin, that is decreased in patients with coronary artery disease. We previously demonstrated that adiponectin acts as a modulator for proinflammatory stimuli and inhibits monocyte adhesion to endothelial cells. The present study investigated the effects of adiponectin on lipid accumulation in human monocyte-derived macrophages. METHODS AND RESULTS: Human monocytes were differentiated into macrophages by incubation in human type AB serum for 7 days, and the effects of adiponectin were investigated at different time intervals. Treatment with physiological concentrations of adiponectin reduced intracellular cholesteryl ester content, as determined using the enzymatic, fluorometric method. The adiponectin-treated macrophages contained fewer lipid droplets stained by oil red O. Adiponectin suppressed the expression of the class A macrophage scavenger receptor (MSR) at both mRNA and protein levels by Northern and immunoblot analyses, respectively, without affecting the expression of CD36, which was quantified by flow cytometry. Adiponectin reduced the class A MSR promoter activity, as measured by luciferase reporter assay. Adiponectin treatment dose-dependently decreased class A MSR ligand binding and uptake activities. The mRNA level of lipoprotein lipase as a marker of macrophage differentiation was decreased by adiponectin treatment, but that of apolipoprotein E was not altered. Adiponectin was detected around macrophages in the human injured aorta by immunohistochemistry. CONCLUSIONS: The adipocyte-derived plasma protein adiponectin suppressed macrophage-to-foam cell transformation, suggesting that adiponectin may act as a modulator for macrophage-to-foam cell transformation. (+info)
Low Serum Adiponectin Levels Predict Future Risk For Asthma In Women - Redorbit
Adiposity is known to be related to asthma. Although a causal link between adiponectin (a protein produced by adipose tissue) and asthma has been demonstrated in mice,. Low serum adiponectin levels predict an increased future risk for developing asthma in middle-aged women, particularly among smokers, according to a new study.. the evidence in humans has been conflicting, said lead author Akshay Sood, MD, MPH, associate professor in the Division of Pulmonary and Critical Care Medicine at the University of New Mexico Health Sciences Center School of Medicine.. In an earlier cross-sectional study, we found an association between low serum adiponectin levels and prevalent asthma among women, but the direction of this association is not known, Dr. Sood continued. In the current study, we examined the longitudinal association between asthma and adiponectin and found that low serum adiponectin concentrations, independent of obesity, predicted a higher risk for developing asthma.. The findings ...
Total and high molecular weight adiponectin have similar utility for the identification of insulin resistance | Cardiovascular...
Insulin resistance (IR) and related metabolic disturbances are characterized by low levels of adiponectin. High molecular weight adiponectin (HMWA) is considered the active form of adiponectin and a better marker of IR than total adiponectin. The objective of this study is to compare the utility of total adiponectin, HMWA and the HMWA/total adiponectin index (SA index) for the identification of IR and related metabolic conditions. A cross-sectional analysis was performed in a group of ambulatory subjects, aged 20 to 70 years, in Mexico City. Areas under the receiver operator characteristic (ROC) curve for total, HMWA and the SA index were plotted for the identification of metabolic disturbances. Sensitivity and specificity, positive and negative predictive values, and accuracy for the identification of IR were calculated. The study included 101 men and 168 women. The areas under the ROC curve for total and HMWA for the identification of IR (0.664 vs. 0.669, P = 0.74), obesity (0.592 vs. 0.610, P = 0.32)
Association between asthma and serum adiponectin concentration in women | Thorax
Murine models have also shown that subcutaneous injection of adiponectin in ovalbumin-sensitised mice prevents the subsequent development of increased airway responsiveness on exposure to ovalbumin.10 31 Taken together, the known anti-inflammatory effects of adiponectin in both mice and humans and the prevention of both allergen-induced airway responsiveness and airway smooth muscle proliferation in murine models has led to the hypothesis that the decreased serum concentrations of adiponectin in obese humans may contribute to the propensity towards asthma in this population.30. This study suggests that a higher serum adiponectin concentration may be a protective factor for current asthma in women, particularly those who are premenopausal. The observed association was independent of adiposity. These results are consistent with a previous cross-sectional study from a different population that suggested that high serum concentrations of leptin, another adipokine, are an independent risk factor for ...
Low adiponectin levels are an independent predictor of mixed and non-calcified coronary atherosclerotic plaques.
Atherosclerosis is the primary cause of coronary artery disease (CAD). There is increasing recognition that lesion composition rather than size determines the acute complications of atherosclerotic disease. Low serum adiponectin levels were reported to be associated with coronary artery disease and future incidence of acute coronary syndrome (ACS). The impact of adiponectin on lesion composition still remains to be determined. We measured serum adiponectin levels in 303 patients with stable typical or atypical chest pain, who underwent dual-source multi-slice CT-angiography to exclude coronary artery stenosis. Atherosclerotic plaques were classified as calcified, mixed or non-calcified. In bivariate analysis adiponectin levels were inversely correlated with total coronary plaque burden (r = -0.21, p = 0.0004), mixed (r = -0.20, p = 0.0007) and non-calcified plaques (r = -0.18, p = 0.003). No correlation was seen with calcified plaques (r = -0.05, p = 0.39). In a fully adjusted multivariate model ...
Longitudinal changes in the relationship between serum adiponectin concentration and cardiovascular risk factors among...
TY - JOUR. T1 - Longitudinal changes in the relationship between serum adiponectin concentration and cardiovascular risk factors among apparently healthy middle-aged adults. AU - Niu, Kaijun. AU - Kobayashi, Yoritoshi. AU - Guan, Lei. AU - Momma, Haruki. AU - Guo, Hui. AU - Cui, Yufei. AU - Otomo, Atsushi. AU - Chujo, Masahiko. AU - Nagatomi, Ryoichi. PY - 2013/9/1. Y1 - 2013/9/1. KW - Adiponectin. KW - Cardiovascular disease risk factors. KW - Longitudinal study. UR - http://www.scopus.com/inward/record.url?scp=84883266773&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84883266773&partnerID=8YFLogxK. U2 - 10.1016/j.ijcard.2012.11.020. DO - 10.1016/j.ijcard.2012.11.020. M3 - Article. C2 - 23182006. AN - SCOPUS:84883266773. VL - 167. SP - 2318. EP - 2320. JO - International Journal of Cardiology. JF - International Journal of Cardiology. SN - 0167-5273. IS - 5. ER - ...
Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced...
As mentioned above, both antidiabetic treatments inhibited the development of hypoadiponectinemia during the animal experiment (Figure 1).. Generally, the effect of insulin on adiponectin serum levels is contentious. In vitro, insulin inhibits the expression of adiponectin at mRNA level , but then it leads to an increased adiponectin secretion from adipocytes [36, 37]. In vivo, there is a good documented association of hypoadiponectinemia with insulin resistance and diabetes mellitus type 2 , but the effect of insulin therapy on serum levels of adiponectin is not well studied so far. A study in five healthy male volunteers showed a decrease of adiponectin levels during a hyperinsulinemic euglycemic clamp . Another study with insulin treatment in a murine model of obesity and diabetes mellitus type 2, the db/db mice, suggested no impact on adiponectin levels . A recent study indicates an elevation of adiponectin levels in a hyperinsulinemia rat model . In this respect, our ...
Association between lifestyle factors and plasma adiponectin levels in Japanese men | Lipids in Health and Disease | Full Text
Adiponectin is an adipocyte-specific protein that plays a role in obesity, insulin resistant, lipid metabolism, and anti-inflammation. Hypoadiponectinemia may be associated with a higher risk for type 2 diabetes and cardiovascular disease. Some studies suggest that adiponectin levels are modulated by lifestyle factors, but little is known about the associations between lifestyle factors and plasma adiponectin levels in Japanese people. We therefore investigated the associations between lifestyle factors and plasma adiponectin levels in general Japanese men. The subjects were 202 Japanese male workers who participated in an annual health check. They provided details about anthropometrical data, blood collection, their use of prescribed medication, and the clinical history of their families. They also completed a self-administered questionnaire about their lifestyles. Subjects with plasma adiponectin levels below 4.0 μg/ml had significantly lower levels of HDL cholesterol and higher levels of BMI, SBP,
The Significance of Elevated Adiponectin in the Treatment of Type 2 Diabetes<...
TY - JOUR. T1 - The Significance of Elevated Adiponectin in the Treatment of Type 2 Diabetes. AU - Combs, Terry P.. AU - Scherer, Philipp E.. PY - 2003/12/1. Y1 - 2003/12/1. N2 - Thiazolidinediones (TZDs) represent a new family of oral antihyperglycemic agents for insulin resistance and type 2 diabetes. A recently discovered effect of TZDs is the induction of a circulating protein produced exclusively in adipocytes, called Acrp30 or adiponectin. To date, 5 clinical studies have confirmed the induction of circulating adiponectin during TZD treatment. Subjects with type 2 diabetes have lower levels of adiponectin than those without diabetes, yet it is very unlikely that the induction of adiponectin during TZD treatment is a secondary effect of improved glycemia. Highly purified recombinant adiponectin showed very dramatic blood glucose (BG) -lowering effects. The increase in circulating adiponectin during TZD treatment is associated with elevated adiponectin levels in adipose tissue. There is ...
C/EBPα Regulates Human Adiponectin Gene Transcription Through an Intronic Enhancer | Diabetes
Two independent studies recently demonstrated that there is a modest level of adiponectin expression in C/EBPα-deficient adipocytes with ectopic expression of PPARγ, whereas expression of both PPARγ and C/EBPα led to production of abundant quantities of adiponectin (23,24). These studies suggest that C/EBPα and PPARγ are required to fully activate adiponectin gene expression. Our study indicates that the regulation of adiponectin gene transcription by C/EBPα and PPARγ is through different sites of the human adiponectin gene. C/EBPα increased adiponectin promoter activity only when the DNA encoding the first intron was present (Fig. 2C). In contrast, overexpression of PPARγ2 and its partner RXRα increased the activity of the adiponectin proximal promoter, and this was not enhanced in the presence of the DNA encoding the first intron (Fig. 2B). These data are consistent with the identification of a PPARγ response element within both the human and mouse adiponectin proximal promoter ...
HMW ADNP elisa kit | Canine High Molecular Weight Adiponectin ELISA Kit
Buy HMW ADNP elisa kit, Canine High Molecular Weight Adiponectin ELISA Kit (MBS025616) product datasheet at MyBioSource, ELISA Kits
Vagal Hyperactivity Due to Ventromedial Hypothalamic Lesions Increases Adiponectin Production and Release | Diabetes
It is well known that circulating adiponectin concentrations are reduced in animal models of obesity and in patients with obesity or metabolic syndrome, despite adipocyte hypertrophy or increased body fat (2-6). However, the details of adiponectin production and release have varied among studies, especially in animal models (10,28,29,32,33). This is probably due to the apparently different etiology of the three types of obese animal models: genetic, diet-induced, and hypothalamic obesity (20,34).. VMH lesion-induced hypothalamic obesity in animals is the only obesity model that shows clear derangements of autonomic nervous activities (hyperactivity of the vagus nerve and hypoactivity of sympathetic nerves) compared with genetic (20), diet-induced obesity (34), and other types of hypothalamic obesity (19). Thus, there is a possibility that this animal model has different characteristics of adiponectin production and release, with resultant change of serum adiponectin, compared with those of other ...
Leptin/adiponectin Ratio in Overweight Patients - Gender Differences | Repository UHC Osijek
OBJECTIVE: Obesity-related atherosclerosis is a systemic disease with a background connected to multiple metabolic-neurohumoral pathways. The leptin/adiponectin ratio has been suggested as an atherosclerotic marker in obese patients. The aim of this study was to assess (1) the significance of the L/A ratio in overweight subjects, (2) the relation with anthropometric/metabolic parameters and (3) gender difference. METHOD: The study included 80 adult males and females, overweight, non-diabetic patients. Biochemical blood analysis and anthropometric and cardiovascular measurements were performed. Serum leptin levels were measured with a radioimmunoassay test and total adiponectin levels with enzyme-linked immunosorbent assay. Leptin/adiponectin ratios were calculated as ratios between total serum concentrations of leptin and adiponectin. RESULTS: Differences between leptin, adiponectin serum levels and leptin/adiponectin ratios are presented in overweight persons, where females have a significantly ...
The Adipokine Adiponectin Can Be Elevated in Graves Ophthalmopathy | IOVS | ARVO Journals
Purpose: : A transgenic mouse model with overexpression of the adipokine adiponectin resulted in progressive expansion of the retrobulbar fat pad leading to fulminant exophthalmos. We undertook a pilot study to determine if adiponectin levels in patients with Graves Ophthalmopathy are elevated as found in the transgenic mouse model. Methods: : From a large urban ophthalmic plastics service 46 consecutive patients with Graves Ophthalmolopathy had their mean serum adiponectin levels determined through an adiponectin ELISA. Clinical data was recorded using standardized criteria. Results: : An ANOVA analysis found that mean adiponectin levels differed significantly between inactive and active Graves disease patients (p=0.0458) and presence of diabetes (p=0.0054). Mean adiponectin level in the active disease group was 15.78 mg/L (SD=8.51), and in the inactive group it was 11.36 mg/L (SD=6.29). Conclusions: : The adipokines such as adiponectin warrant further investigation regarding its role in the ...
A Novel Role for Adiponectin in the Regulation of Inflammation | Arteriosclerosis, Thrombosis, and Vascular Biology
A number of bioactive molecules secreted from fat tissue, referred to as adipokines, could participate in the development of obesity-related complications through regulation of inflammatory responses.9,10 Most adipokines are proinflammatory. In contrast, adiponectin, also referred to as adipocyte complement-related protein 30 (ACRP30), is an antiinflammatory adipokine that is abundantly present in blood stream. Whereas adiponectin is expressed almost exclusively in adipose tissue,11,12 plasma adiponectin levels are paradoxically decreased in obese individuals.13 This regulation of adiponectin results, at least in part, from the upregulation of tumor necrosis factor (TNF)-α and other proinflammatory cytokines which inhibits the synthesis of adiponectin in the obese state. Low plasma adiponectin levels, also known as hypoadiponectinemia, are closely associated with the increased prevalence of obesity-linked disorders including type 2 diabetes, coronary heart disease, and hypertension.9 Studies ...
Treatment-Induced Changes in Plasma Adiponectin Do Not Reduce Urinary by Kieren J. Mather, Qing Pan et al.
BACKGROUND AND OBJECTIVES: Molecular data suggests that adiponectin may directly regulate urinary albumin excretion. In the Diabetes Prevention Program (DPP) we measured adiponectin and albuminuria before and after intervention, and we previously reported increases in adiponectin with interventions. Here we have used the DPP dataset to test the hypothesis that treatment-related increases in adiponectin may reduce albuminuria in obesity. DESIGN, SETTING, PARTICIPANTS AND METHODS: We evaluated cross-sectional correlations between plasma adiponectin and urinary albumin excretion at baseline, and the relationship of treatment-related changes in adiponectin and albuminuria. Baseline and follow-up urine albumin to creatinine ratios (ACR (albumin to creatinine ratio)) and plasma adiponectin concentration were available in 2553 subjects. RESULTS: Adjusting for age, sex and race/ethnicity, we observed a statistically significant but weak inverse relationship between adiponectin and ACR at baseline (conditional
Abstract 817: Glucose Loading Increases Adiponectin Levels in Subjects With Impaired Glucose Tolerance and Impairs Endothelial...
Background: Adiponectin is an adipokine with beneficial effect on vascular function. Although adiponectin levels are decreased in patients with diabetes mellitus (DM), it is unclear whether impaired glucose tolerance (IGT) affects adiponectins release, or whether glucose intake modifies its release from adipocytes. We examined the effect of glucose on serum adiponectin/insulin and endothelial function, in subjects with IGT, patients with DM and healthy individuals.. Methods: The study population consisted of 113 subjects: 19 with IGT, 78 with DM and 16 controls. All subjects underwent glucose loading (75g oral glucose), and blood samples were obtained at baseline and after 3 hours. Endothelial function was evaluated by gauge-strain plethysmography at baseline and every 1h, and endothelium-dependent dilation (EDD) was determined. Adiponectin and insulin were measured at baseline and at 3h.. Results: Glucose loading increased adiponectin levels in healthy (70.1±8.5 to 80.8±11.4 ng/ml, p,0.05) ...
eNOS plays a major role in adiponectin synthesis in adipocytes
Abstract: Nitric oxide (NO) stimulates mitochondrial biogenesis. We recently reported that adiponectin synthesis is regulated by mitochondrial function in adipocytes. This study was undertaken to test the hypothesis that endothelial NO synthase (eNOS) plays an important role in adiponectin synthesis by producing NO and enhancing mitochondrial function in adipocytes. We examined the effects of eNOS knockdown on adiponectin synthesis in 3T3-L1 adipocytes and also examined plasma adiponectin levels and the mitochondria in adipose tissue of eNOS knockout (eNOS-/-) mice with and without chronic administration of a NO donor. In cultured 3T3-L1 adipocytes, eNOS siRNA decreased rosiglitazone-induced adiponectin secretion, which was associated with decreases in mitochondrial proteins and biogenesis factors. Plasma adiponectin concentrations were reduced in adult eNOS-/- mice compared with age-matched wild-type mice. Mitochondrial contents in adipose tissue were reduced in eNOS-/- mice, and this was ...
In the current study, we showed that in patients with AMI, low plasma adiponectin was associated independently with increased risk of developing T2DM in a linear dose-response relationship. Even in patients with low glucose, adiponectin still added significantly to the prognostic value, as the risk of developing T2DM was higher in patients with low adiponectin/low glucose compared with patients with high adiponectin/low glucose. However, the risk increased by ∼10-fold in patients who were characterized by the combination of low adiponectin and high blood glucose.. Low plasma adiponectin has been suggested to be causally involved in pathways leading to T2DM. The binding of adiponectin to its receptors (adiR1/R2) directly suppresses hepatic gluconeogenesis and stimulates fatty acid oxidation in liver and muscle, glucose uptake in skeletal muscle, and insulin secretion (1,10).. In a study of 335 cases of incident T2DM from the Whitehall II study, adiponectin was measured three times per ...
Product XKine Adiponectin • HumanZyme
Adiponectin is an adipose-derived secreted protein containing 226 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages). Recombinant adiponectin is a multimeric glycoprotein containing amino acids Glu-19 to Asn-244 of the adiponectin precursor protein fused to an N-terminal histidine tag.. ...
The Effect of Zinc Supplementation on Serum Adiponectin Concentration and Insulin Resistance in First Degree Relatives of...
Iranian Journal of Diabetes and Obesity is scientific quarterly journal published by Shahid Sadoughi University of Medical Sciences
Ethnic Differences in the Relationship Between Adiponectin and Insulin Sensitivity in South Asian and Caucasian Women |...
The data presented are consistent with those of previous studies, demonstrating that adiponectin concentrations are lower in SA individuals (3,4), and show for the first time that this is also true for HMW adiponectin. However, these findings do not necessarily mean that lower total or HMW adiponectin concentration accounts for the increased prevalence of insulin resistance in SA individuals. The difference between the SA and CAU groups occurs because, in contrast to the presence of higher values in CAU-IS compared with -IR women, total and HMW adiponectin concentrations were not higher in IS than IR individuals of SA ancestry. This lack of a difference between the two SA groups occurred despite the fact that the SSPG concentrations were threefold lower in the IS individuals. Thus, the ethnic difference in adiponectin concentrations is due to the fact that adiponectin concentrations remain low in SAs, irrespective of the degree of insulin sensitivity, a finding that does not appear to support ...
The Multi-Level Action of Fatty Acids on Adiponectin Production by Fat Cells
Current epidemics of diabetes mellitus is largely caused by wide spread obesity. The best-established connection between obesity and insulin resistance is the elevated and/or dysregulated levels of circulating free fatty acids that cause and aggravate insulin resistance, type 2 diabetes, cardiovascular disease and other hazardous metabolic conditions. Here, we investigated the effect of a major dietary saturated fatty acid, palmitate, on the insulin-sensitizing adipokine adiponectin produced by cultured adipocytes. We have found that palmitate rapidly inhibits transcription of the adiponectin gene and the release of adiponectin from adipocytes. Adiponectin gene expression is controlled primarily by PPARγ and C/EBPα. Using mouse embryonic fibroblasts from C/EBPα-null mice, we have determined that the latter transcription factor may not solely mediate the inhibitory effect of palmitate on adiponectin transcription leaving PPARγ as a likely target of palmitate. In agreement with this model, palmitate
The clinical implications of blood adiponectin in cardiometabolic disorders. - Semantic Scholar
Adipose tissue is now accepted by the scientific and medical community to be a genuine endocrine organ, in addition to its classical role as an energy store. Adiponectin is one of the many adipocytokines that are secreted almost exclusively by adipose tissue. Alteration in blood adiponectin concentrations has been linked to many human diseases in numerous cross-sectional and prospective studies. In this review, we describe briefly the biological effects of adiponectin as revealed by basic scientific investigations. We also summarize the principles of blood adiponectin assays. Overall, lower blood adiponectin concentration is found in subjects with obesity, type 2 diabetes mellitus, dyslipidemia, and hypertension. These medical conditions are components of the metabolic syndrome and major risk factors for accelerated atherosclerosis. Plasma adiponectin levels are also expected to be lower in subjects with cardiovascular diseases, such as coronary artery disease, ischemic stroke and peripheral artery
Abstract 16583: Variations of Circulating Levels of Adiponectin Impact Two-Years Cardiovascular Outcomes in Patients With Acute...
Background: Adiponectin is a circulating adipose-derived cytokine with anti-inflammatory and antiatherosclerotic properties. Low adiponectin concentrations are related with endothelial dysfunction, hypertension, and incidence of type 2 diabetes. However the relationship of adiponectin concentrations and cardiovascular outcomes in patients with pre-existing cardiovascular disease is unclear.. Methods: We used data from patients enrolled in the prospective, multicentre French registry of Acute ST elevation or non-ST-elevation Myocardial Infarction(Fast-MI). Blood samples were drawn immediately at admission. Adiponectin concentrations were measured using a validated immunoassay (n= 932 patients, of whom 279 with diabetes). Cox proportional hazards regression models were used for assessing outcomes, e.g all-cause mortality and recurrent AMI during a 2-year follow-up, according to adiponectin levels as continuous variable and tertiles.. Results: During follow-up, 162(17%) patients died or had a ...
Inverse association between serum adiponectin level and transaminase activities in Japanese male workers<...
TY - JOUR. T1 - Inverse association between serum adiponectin level and transaminase activities in Japanese male workers. AU - Yokoyama, Hirokazu. AU - Hirose, Hiroshi. AU - Ohgo, Hideki. AU - Saito, Ikuo. PY - 2004/7. Y1 - 2004/7. N2 - Background/Aims Since a novel polypeptide named adiponectin was shown to prevent the development of steatosis and steatohepatitis in animal models, we studied whether it was also possible in a clinical situation. Methods Associations between serum adiponectin levels and serum transaminase activities were studied in 791 Japanese males who were not heavy drinkers, and had no autoimmune or HBV- or HCV-induced liver diseases. Results Various markers of metabolic diseases including levels of body mass index (BMI), serum triglyceride, total cholesterol, and insulin resistance assessed by the homeostasis model were significantly higher in subjects with increased transaminase activities when compared to those with normal activities. Single regression analyses ...
Association of low serum adiponectin levels with erosive esophagitis in men: An analysis of 2405 subjects undergoing physical...
TY - JOUR. T1 - Association of low serum adiponectin levels with erosive esophagitis in men. T2 - An analysis of 2405 subjects undergoing physical check-ups. AU - Kato, Motohiko. AU - Watabe, Kenji. AU - Hamasaki, Toshimitsu. AU - Umeda, Miyuki. AU - Furubayashi, Aiko. AU - Kinoshita, Kazuo. AU - Kishida, Osamu. AU - Fujimoto, Takashi. AU - Yamada, Akira. AU - Tsukamoto, Yoshifumi. AU - Yamamoto, Shunsuke. AU - Kamada, Yoshihiro. AU - Yoshida, Yuichi. AU - Kiso, Shinichi. AU - Tsutsui, Shusaku. AU - Kihara, Shinji. AU - Hayashi, Norio. AU - Matsuzawa, Yuji. PY - 2011/12/1. Y1 - 2011/12/1. N2 - Obesity is a risk factor for gastro-esophageal reflux disease (GERD). It is generally considered that intra-abdominal pressure in obese subjects is involved in the pathogenesis of GERD through acid exposure to the esophagus. Recently, visceral fat has been recognized as an endocrine organ that secretes various adipocytokines including adiponectin. The aim of this study was to elucidate the relation between ...
PPARγ-Activating Angiotensin Type-1 Receptor Blockers Induce Adiponectin | Hypertension
The present study demonstrates that PPARγ-activating ARBs induce adiponectin protein expression at a post-transcriptional level, independently of their AT1R-blocking properties. In addition, AT2R activation resulted in adiponectin upregulation. The PPARγ-activating ARB irbesartan improved parameters of insulin sensitivity in obese Zucker rats, which was associated with the prevention of adiponectin serum depletion.. We and others could recently demonstrate that a subset of ARBs including irbesartan has the potential to activate the insulin-sensitizing nuclear hormone receptor PPARγ, completely independent from their AT1R blocking properties.8,10 PPARγ activation has been shown to stimulate adiponectin expression in adipocytes and to upregulate adiponectin plasma levels in animals and humans.6,11 In the present study, pharmacological antagonism of PPARγ completely blocked irbesartan-induced adiponectin expression in vitro. In addition, adiponectin expression in adipocytes and fat tissue was ...
Serum Adiponectin in Chinese Population and Its Correlation to Cardiovascular and Cerebrovascular Diseases - Full Text View -...
Adiponectin (Ad) is an abundant protein hormone regulatory of numerous metabolic processes, anti-inflammatory, vascular protective, and anti-ischemic properties. Since its 1995 discovery, Ad has garnered considerable attention for its role in diabetic and cardiovascular pathology. Clinical observations have demonstrated the association of hypoadiponectinemia in patients with obesity, cardiovascular disease, and insulin resistance. There is growing evidence supporting Ad can act as a novel risk factor for cardiovascular and cerebrovascular injury. This 5 years follow-up study will focus on serum adiponectin concentration, activity and isoforms in Chinese population and its correlation to cardiovascular and cerebrovascular diseases ...
Veterinary Sciences | Free Full-Text | Myocardial Adiponectin Isoform Shift in Dogs with Congestive Heart Failure-A Comparison...
Adiponectin is the most abundant plasma adipokine, and is well known for its role in energy homeostasis and cardiac protection. In humans with dilated cardiomyopathy, myocardial adiponectin protein expression is reduced compared to normal hearts and has been implicated in the pathology of cardiomyopathy. Serum adiponectin levels are often conflicting, with higher levels associated with poor survival in humans with congestive heart failure (CHF). We evaluated adiponectin serum concentrations and myocardial protein expression in dogs with naturally occurring myxomatous mitral valve disease and CHF. We compared the findings to active and hibernating brown bears as bears are adapted to endure an extreme period of low cardiac output during their annual hibernation. Bears exhibited largely the active high-molecular weight (HMW) versus the low-molecular weight isoforms of myocardial adiponectin (HMW:LMW = 6.3) during both the active period and hibernation, while healthy dogs exhibited a more balanced mix of
Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma
Introduction: Adiponectin is anti-inflammatory and anti-tumor cytokine secreted exclusively from adipocytes. Thereis a growing evidence of association between adiponectin gene polymorphism and development of pancreatic cancer.The current study aimed at evaluation of the possible association between selected adiponectin gene polymorphism andthe risk of pancreatic cancer. Methods: Prospective case-control study included 77 patients (29 women and 48 men)with biopsy-proven pancreatic adenocarcinoma and 97 healthy control. Blood samples from all included participantswere genotyped for 3 single nucleotide polymorphism (SNPs) of adiponectin genes (rs1501299C|A, rs266729C|G andrs2241766G|T) by PCR. Clinical, biochemical, and radiological data analyzed. Results: We demonstrated a significantassociation between the three studied SNPs (rs1501299, rs266729, and rs2241766) and increased risk of pancreaticadenocarcinoma (p|0.001). Furthermore, in clinical correlation analysis, Patients with rs2241766 polymorphismhave
Systemic fate of the adipocyte-derived factor adiponectin<...
TY - JOUR. T1 - Systemic fate of the adipocyte-derived factor adiponectin. AU - Halberg, Nils. AU - Schraw, Todd D.. AU - Wang, Zhao V.. AU - Kim, Ja Young. AU - Yi, James. AU - Hamilton, Mark P.. AU - Luby-Phelps, Kate. AU - Scherer, Philipp E.. PY - 2009/9. Y1 - 2009/9. N2 - OBJECTIVE - The adipocyte-derived secretory protein adiponectin has been widely studied and shown to have potent insulin-sensitizing, antiapoptotic, and anti-inflammatory properties. While its biosynthesis is well understood, its fate, once in circulation, is less well established. RESEARCH DESIGN AND METHODS - Here, we examine the half-life of adiponectin in circulation by tracking fluorescently labeled recombinant adiponectin in the circulation, following it to its final destination in the hepatocyte. RESULTS - Despite its abundant presence in plasma, adiponectin is cleared rapidly with a half-life of ∼75 min. A more bioactive version carrying a mutation at cysteine 39 is cleared within minutes. Even though ...
Association of ADIPOQ gene with obesity and adiponectin levels in Malaysian Malays
Studies have shown that single-nucleotide polymorphisms (SNPs) on the ADIPOQ gene have been linked with obesity and with adiponectin levels in various populations. Here, we aimed to investigate the association of ADIPOQ rs17366568 and rs3774261 SNPs with obesity and with adiponectin levels in Malaysian Malays. Obesity parameters and adiponectin levels were measured in 574 subjects. Genotyping was performed using real-time polymerase chain reaction and Sequenom MassARRAY. A significant genotypic association was observed between ADIPOQ rs17366568 and obesity. The frequencies of AG and AA genotypes were significantly higher in the obese group (11%) than in the non-obese group (5%) (P=0.024). The odds of A alleles occurring among the obese group were twice those among the non-obese group (odds ratio 2.15; 95% confidence interval 1.13-4.09). However, no significant association was found between allelic frequencies of ADIPOQ rs17366568 and obesity after Bonferroni correction (P>0.025) or between ...
HKU Scholars Hub: Chronic adiponectin deficiency leads to Alzheimers disease-like cognitive impairments and pathologies...
BACKGROUND: Insulin resistance is the major pathogenesis underlying type 2 diabetes mellitus (T2DM) and these patients have doubled risk of Alzheimers disease (AD). Increasing evidence suggests that insulin resistance plays an important role in AD pathogenesis, possibly due to abnormal GSK3β activation, causing intra- and extracellular amyloid-beta (Aβ) accumulation. Adiponectin (APN) is an adipokine with insulin-sensitizing and anti-inflammatory effects. Reduced circulatory APN level is associated with insulin resistance and T2DM. The role of APN in AD has not been elucidated. In this study, we aim to examine if adiponectin deficiency would lead to cerebral insulin resistance, cognitive decline and Alzheimers-like pathology in mice. METHODS: To study the role of adiponectin in cognitive functions, we employed adiponectin-knockout (APN-KO) mice and demonstrated chronic APN deficiency in their CNS. Behavioral tests were performed to study the cognitions of male APN-KO mice. Brains and tissue ...
Validating impact of temporal changes of adiponectin in relation to ROP development | IOVS | ARVO Journals
Purpose : To validate earlier found physiologic response patterns explaining retinopathy of prematurity (ROP) development in infants born very preterm. Generally adiponectin production is up-regulated by weight loss and down regulated by weight gain, oxidative stress as well as pro-inflammatory cytokines. Disturbed homeostasis, impaired growth and inflammation are factors closely related to ROP development. This study assessed the longitudinal postnatal development of serum adiponectin levels and ROP development in a new cohort of very preterm infants. Methods : A study was performed in 90 infants with gestational age (GA) , 28 weeks with a mean (SD) gestational age at birth of 25.2 (1.4) weeks and mean (SD) birth weight of 882 (220) g. Cord blood samples and thereafter venous blood samples were obtained at postnatal day 1, 7, 14, 28 days and at postmenstrual age 32, 36 and 40 weeks. Serum adiponectin levels were assayed using a human adiponectin ELISA kit (E091M, Mediagnost, Germany). The ...
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Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines. - Nuffield...
AIMS/HYPOTHESIS: Pregnancy, a state of insulin resistance, is associated with elevated levels of cytokines and profound alterations in metabolism. Serum adiponectin, an adipokine with anti-inflammatory and insulin-sensitising properties, has been shown to be lower in patients with gestational diabetes mellitus, a state of greater insulin resistance than normal pregnancies. Hypothesising that the human placenta is a source of adiponectin, we investigated its expression and secretion, and the regulation by cytokines of adiponectin and its receptors. METHODS: Real-time RT-PCR, radioimmunoassay, Western blotting, radioligand binding and immunofluorescent analyses were applied to demonstrate the expression, secretion and functionality of placental adiponectin. RESULTS: Adiponectin gene expression and protein were found in the human term placenta, with expression primarily in the syncytiotrophoblast. RIA of conditioned media from explant experiments revealed that the placenta can secrete adiponectin in vitro.
On the basis of the above-reported properties unraveled by basic science studies, it would be conceivable to hypothesize that adiponectin exerts beneficial effects on metabolic and cardiovascular traits in human beings. In fact, in pioneering cross-sectional studies carried out in Pima Indians, circulating adiponectin levels correlated positively with both skeletal muscle (21) and liver (22) insulin sensitivity. In addition, in this same population, adiponectin was negatively correlated with inflammatory markers (23). Along the same line is the observation that insulin-sensitizing agents increase adiponectin concentrations in humans (24). In addition, a prospective study has also shown that low plasma adiponectin concentration predicts the deterioration of insulin sensitivity over time (25).. Unfortunately, the observational design of all such studies could not address whether the reported associations were due to a positive effect of adiponectin on insulin sensitivity. In this regard, it must ...
Gene Variation Linked To Colon Cancer | EmaxHealth
The hormone adiponectin is secreted from fat cells. Overweight and obese people are known to have less adiponectin secreted and they are definitely at higher risk for suffering from cancers. The mechanism linking hormone existence to overall health is the following: high adiponectin levels in blood are able to suppress blood vessels inflammation, this leads to increased metabolism.. Therefore, higher adiponectin levels decrease the risk of obesity, diabetes, heart disease, breast cancer and now it is also linked to colorectal cancer. It is clear that hormone adiponectin makes people healthier, but how exactly the hormone is being secreted from fat cells is yet unclear.. According to American Cancer Society statistics, colorectal cancer affects 1.2 million and kills 630000 people worldwide each year. This year is estimated to have 149000 newly diagnosed and 50000 cases in US. About 1/3 of cases are associated with family history, other factors causing the disease are believed to be diet reach in ...
Calcium is involved in formation of high molecular weight adiponectin - Fingerprint - [email protected]
Fingerprint Dive into the research topics of Calcium is involved in formation of high molecular weight adiponectin. Together they form a unique fingerprint. ...
Adiponectin - Wikipedia
Adiponectin is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid oxidation. Adiponectin is secreted from adipose tissue (and also from the placenta in pregnancy) into the bloodstream and is very abundant in plasma relative to many hormones. Many studies have found adiponectin to be inversely correlated with body mass index in patient populations. However, a meta analysis was not able to confirm this association in healthy adults. Circulating adiponectin concentrations increase during caloric restriction in animals and humans, such as in patients with anorexia nervosa. This observation is surprising, given that adiponectin is produced by adipose tissue. However, a recent study suggests that adipose tissue within bone marrow, which increases during caloric restriction, contributes to elevated circulating adiponectin in this context.. Transgenic mice with increased adiponectin show reduced adipocyte differentiation and ...
UCP1-3826 AG+GG genotypes, adiponectin, and leptin/adiponectin ratio in severe obesity
ABSTRACT. Background and aims: Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are well-recognized complications of obesity. This study was designed to evaluate the role of the UCP1 -3826 A,G polymorphism, adiponectin levels, leptin/adiponectin ratio (L/A), and main biochemical parameters in 102 unrelated severely obese adults [61 females and 41 males, median body mass index (BMI) = 47.8 kg/m2] with NAFLD, with (MS+) or without MS (MS-) from Southern Italy. Subject and methods: The UCP1 polymorphism was tested by the TaqMan method, main biochemical parameters by routinary methods, adiponectin, and leptin serum levels by enzyme-linked immunosorbent assay. MS was diagnosed according to the American Heart Association criteria, liver steatosis was detected by ultrasound. Results: MS was present in 53% male and 66% female obese patients. Only total cholesterol (p=0.04 males and p=0.002 females) and L/A ratio (p=0.03 males) differed between MS+ and MS- obese patients. At ...
ActoFactor™ Recombinant Human Adiponectin (Adipocyte Complement Related Protein of 30 kDa; E. coli) | Creative Bioarray
Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 amino acid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells (adipokine). The protein belongs to the soluble defence collagen superfamily; it has a collagen-like domain structurally homologous with collagen VIII and X and complement factor C1q-like globular domain. Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. The human Adiponectin is expressed in E. coli as a recombinant 25.1 kDa sinle, non-glycosylated polypeptide chain containing 231 amino acid residues ...
FRI0010 Effects of leptin and adiponectin on proliferation, activation and th17 differentiation were significantly increased in...
Results MN and CD4+T cells from RA patients showed a higher proliferative effect when exposed to leptin and adiponectin in comparison with healthy donors. Interesting, the level of proliferation correlated with the DAS28 of patients. Similarly, cells from patients were more sensitive to leptin and adiponectin treatment when evaluating CD25+/CD69+ cell expression and IL-2, TNF secretion, in comparison to healthy donor cells. Comparatively, adiponectin treatment was more effective to induce the expression of CD25, CD69 and IL-6, whereas leptin was a better inductor of IL-2 and TNF-a on the RA patient cells. Comparing this with the clinical activity of patients, we only observed a significant correlation between the DAS28 and the IL-2 induction when exposed to leptin. Preliminary assays showed that leptin was also capable to rescue MN cells from an apoptotic environment by a mechanism related to IL-2 secretion. On the other hand, MN cells from RA patients incubated for several days with leptin ...
PRIME PubMed | Association of low adiponectin levels with the metabolic syndrome--the Chennai Urban Rural Epidemiology Study ...
PubMed journal article: Association of low adiponectin levels with the metabolic syndrome--the Chennai Urban Rural Epidemiology Study (CURES-4). Download Prime PubMed App to iPhone, iPad, or Android
Effect of Exercise Training on Adiponectin Receptor Expression and Insulin Resistance in Mice Fed a High Fat Diet | Science...
Problem statement: Adiponectin is an adipocyte secreted hormones, exerts its effects via the specific receptors. AdipoR1 and adipoR2 and plays a pivotal role in lipid and glucose metabolism. Approach: We investigated the effect of increased physical activities on insulin resistance and if this effect is modulated through adiponectin receptor expression. Results: We also assessed the effect of High Fat Diet (HFD) on adipoRs expression. Mice were subjected to 16 weeks of HFD protocol then to 4, 6 and 8 weeks of exercise training. Following the experimental protocol the fasting plasma glucose, insulin and index of Homeostasis Model Assessment of insulin Resistance (HOMA-R) were evaluated. The mRNA expression of adiponectin receptors genes were also analyzed using reverse transcription RT-PCR. The consumption of high fat diet by the mice for 16 weeks resulted in a significant increase in weight associated with insulin resistance and associated with significant decrease in adiponectin receptors R1 and R2
Serum Adiponectin Levels in Patients with Familial Mediterranean Fever | Bentham Science
Title: Serum Adiponectin Levels in Patients with Familial Mediterranean Fever. VOLUME: 17 ISSUE: 10. Author(s):Goksal Keskin, Ali Inal and Lale Ozisik. Affiliation:DYBEA Hospital, Head of 4. Internal Medicine Department, Ankara, Turkey.. Keywords:Adiponectin, IL-6, FMF. Abstract: Familial mediterranean fever (FMF) is a systemic disorder characterized by recurrent attacks of fever and polyserositis. In FMF, several pro-inflammatory cytokines, such as IL-6, have been found to be elevated during the attacks. In recent years, it is shown that some proteins originated from adipose tissue play important role in inflammatory process. One of them, adiponectin decreases the expression of adhesion molecules and inhibits the attachment of active macrophages to the endothelial surface, so that it acts antiinflammatory effect. In this study, we analyzed the possible role of serum adiponectin in the pathogenesis of FMF. Thirty five patients with FMF and 13 healthy controls (5 female,8 male; mean age 22.3 ± ...
Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter...
TY - JOUR. T1 - Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity. AU - Kyriakou, Theodosios. AU - Collins, Laura J.. AU - Spencer-Jones, Nicola J.. AU - Malcolm, Claire. AU - Wang, Xiaoling. AU - Snieder, Harold. AU - Swaminathan, Ramasamyiyer. AU - Burling, Keith A.. AU - Hart, Deborah J.. AU - Spector, Tim D.. AU - ODell, Sandra D.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2008/8. Y1 - 2008/8. N2 - Adiponectin is an insulin sensitiser in muscle and liver, and low serum levels characterise obesity and insulin resistance. Eight tagging single nucleotide polymorphisms (tSNPs) in the ADIPOQ gene and promoter were selected, and association with serum adiponectin was tested, in two independent samples of Caucasian women: the Chingford Study (n = 808, mean age 62.8 ± 5.9 years) and Twins UK (n = 2,718, mean age 47.4 ± 12.6 years). In the Chingford cohort, -11391 G/A, -10066 G/A ...
Inhibition of islet immunoreactivity by adiponectin is attenuated in human type 1 diabetes. - Radcliffe Department of Medicine
CONTEXT: Adiponectin is an adipocyte-derived cytokine with insulin-sensitizing and antiinflammatory properties. These dual actions have not previously been examined in the context of human disease. OBJECTIVES: Our objective was to examine the adiponectin axis in type 1 diabetes (T1D). T1D is an autoimmune inflammatory disease resulting from pancreatic β-cell destruction, in which insulin resistance associates with progression to disease. DESIGN, PATIENTS, AND INTERVENTIONS: We measured circulating adiponectin and adiponectin receptor expression on blood-immune cells from 108 matched healthy, T1D, and type 2 diabetic subjects. We tested adiponectin effect on T cell proliferation to islet antigens and antigen-presenting function of monocyte-derived dendritic cells (mDCs). Lastly, we assessed the effect of a 3-week lifestyle intervention program on immune cell adiponectin receptor expression in 18 healthy subjects. RESULTS: Circulating concentrations of adiponectin were not affected by T1D. However,
A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels
The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n = 8,531) and sought validation of the lead single nucleotide polymorphisms (SNPs) in 5 additional cohorts (n = 6,202). Five SNPs were genome-wide significant in their relationship with adiponectin (P≤5×10−8). We then tested whether these 5 SNPs were associated with risk of T2D and CHD using a Bonferroni-corrected threshold of P≤0.011 to declare statistical significance for these disease associations. SNPs at the adiponectin-encoding ADIPOQ locus demonstrated the strongest associations with adiponectin levels (P-combined = 9.2×10−19 for lead SNP, rs266717, n = 14,733). A novel variant in the ARL15 (ADP-ribosylation factor-like 15) gene was associated with lower circulating levels of adiponectin (rs4311394-G, P-combined = 2.9×10−8, n = ...
Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer : a Mendelian Randomization...
Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene. We created an ADIPOQ allele score that explained approximately 3% of the interindividual variation in adiponectin concentrations. The ADIPOQ allele score was not associated with risk of colorectal cancer in logistic regression analyses (pooled OR per score-unit unit 0.97, 95% CI 0.91, 1.04). Genetically determined twofold ...
Design and development of a peptide-based adiponectin receptor agonist for cancer treatment | BMC Biotechnology | Full Text
Adiponectin, a fat tissue-derived adipokine, exhibits beneficial effects against insulin resistance, cardiovascular disease, inflammatory conditions, and cancer. Circulating adiponectin levels are decreased in obese individuals, and this feature correlates with increased risk of developing several metabolic, immunological and neoplastic diseases. Thus, pharmacological replacement of adiponectin might prove clinically beneficial, especially for the obese patient population. At present, adiponectin-based therapeutics are not available, partly due to yet unclear structure/function relationships of the cytokine and difficulties in converting the full size adiponectin protein into a viable drug. We aimed to generate adiponectin-based short peptide that can mimic adiponectin action and be suitable for preclinical and clinical development as a cancer therapeutic. Using a panel of 66 overlapping 10 amino acid-long peptides covering the entire adiponectin globular domain (residues 105-254), we identified the 149
Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease<...
TY - JOUR. T1 - Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. AU - Iacobellis, Gianluca. AU - Pistilli, Daniela. AU - Gucciardo, Marco. AU - Leonetti, Frida. AU - Miraldi, Fabio. AU - Brancaccio, Gianluca. AU - Gallo, Pietro. AU - Tiziana Di Gioia, Cira Rosaria. PY - 2005/3/21. Y1 - 2005/3/21. N2 - Background: Intra-peritoneal adipose tissue is recognized as a predictor of metabolic syndrome and may contribute to the risk for cardiovascular disease by the production of adipocytokines, including adiponectin. Nevertheless, there is no knowledge on whether other visceral depots of adipose tissue, including the epicardial fat, have any metabolically active role, including production of adiponectin. Aim of the study: We sought to evaluate adiponectin protein expression in epicardial adipose tissue in vivo both in patients with severe coronary artery disease (CAD) and in subjects without CAD. Methods: Twenty-two patients were ...
The association of SNP276G|T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight...
TY - JOUR. T1 - The association of SNP276G,T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss. AU - Shin, M. J.. AU - Jang, Y.. AU - Koh, S. J.. AU - Chae, J. S.. AU - Kim, O. Y.. AU - Lee, J. E.. AU - Ordovas, J. M.. AU - Lee, J. H.. PY - 2006/12/21. Y1 - 2006/12/21. N2 - Objective:The purpose of this study was to determine whether common single nucleotide polymorphisms (SNPs) at the adiponectin (ADIPOQ) locus influence changes in circulating adiponectin and the features of insulin resistance in response to a weight loss intervention.Subjects:In total, 294 nondiabetic/overweight-obese Koreans participated in a clinical intervention study lasting 12 weeks involving a caloric reduction of -300kcal/day.Methods: Plasma adiponectin, blood lipids, glucose and insulin concentrations were measured at baseline and after weight loss. Insulin resistance was estimated by homeostasis model assessment insulin resistance (HOMA-IR) derived from fasting ...
Role of adiponectin in adipose tissue wound healing | GMR | Genetics and Molecular Research | The Original by FUNPEC-RP
The purpose of this study was to investigate the mechanism behind adipose tissue wound healing (ATWH). The preadipocyte cell line 3T3-L1 was cultured and expression of adiponectin receptors (AdipoR1/2) was detected by immunohistochemistry and reverse transcription polymerase chain reaction. The concentration of adiponectin secreted at different cell densities was measured by enzyme-linked immunosorbent assay, while preadipocyte proliferation and migration were determined in vitro by MTT and wound closure assays. AdipoR1/2 were found to be expressed in 3T3-L1 preadipocytes. There were no statistically significant differences in the concentrations of adiponectin secreted by cell solutions of different densities (P | 0.05). In addition, adiponectin was seen to promote the growth and migration of preadipocytes. In conclusion, adiponectin may regulate ATWH by promoting preadipocyte proliferation and migration, and its systemic and/or local application is proposed as a promising therapeutic approach for the
Serum Adiponectin levels in Different Phenotypes of Polycystic Ovary Syndrome
ABSTRACT. Objectives: to evaluate and compare serum adiponectin levels in different phenotypes of polycystic ovary syndrome (PCOS) and to investigate their correlation with endocrine and metabolic parameters. Material and methods: we studied 5 groups of patients: A (n = 20): H (hyperandrogenism) + O (oligoanovulation) + P (polycystic ovary) [classic phenotype]; B (n = 17): H + O [classic phenotype but normal ovaries]; C (n = 15): H + P [Ovulatory phenotype]; D (n = 17): O + P [Normoandrogenic phenotype]; and E (n = 16) control group. Body mass index, waist circumference, waist/hip ratio, blood pressure and hirsutism were evaluated. Serum concentrations of adiponectin, insulin, Creactive protein, SHBG, androgens and lipids were measured. Oral glucose tolerance test was performed. Results: there were no differences between the groups in terms of age and BMI. Total cholesterol, LDL-C and triglyceride levels were higher in phenotype A than in C (P < 0.05); HDL-C was slightly lower in phenotype D ...
Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory...
Oxidative stress plays a critical role in the vascular complications of type 2 diabetes. We examined the effect of type 2 diabetes on NADPH oxidase in human vessels and explored the mechanisms of this interaction. Segments of internal mammary arteries (IMAs) with their perivascular adipose tissue (PVAT) and thoracic adipose tissue were obtained from 386 patients undergoing coronary bypass surgery (127 with type 2 diabetes). Type 2 diabetes was strongly correlated with hypoadiponectinemia and increased vascular NADPH oxidase-derived superoxide anions (O2˙(-)). The genetic variability of the ADIPOQ gene and circulating adiponectin (but not interleukin-6) were independent predictors of NADPH oxidase-derived O2˙(-). However, adiponectin expression in PVAT was positively correlated with vascular NADPH oxidase-derived O2˙(-). Recombinant adiponectin directly inhibited NADPH oxidase in human arteries ex vivo by preventing the activation/membrane translocation of Rac1 and downregulating p22(phox) through a
The effects of adiponectin gene polymorphisms on the progression of carotid intima-media thickness
Background and aims: Previous studies have documented environmental risk factors for the progression of carotid intima-media thickness (IMT); however, few have examined genetic risk factors for the progression of carotid IMT and none has specifically examined subjects with type 2 diabetes. This study examined the association between single nucleotide polymorphisms in the adiponectin gene and the progression of carotid IMT in patients with type 2 diabetes.. Materials and methods: We performed common carotid ultrasonography at baseline and 33 39 months later in 324 consecutive subjects with type 2 diabetes. The genotypes of the adiponectin gene were determined using a single base primer extension method.. Results: The A allele of −11426A/G (P,0.05), G allele of −10066C/G (P=0.001), A allele of −8564G/A (P,0.01), A allele of −450A/G (P,0.05), and G allele of 276G/T (P,0.01) were associated with progressive carotid IMT. In the haplotype analysis, the AC/AC haplotype combination in block 1, ...
Expression of adiponectin in the subchondral bone of lumbar facet joints with different degrees of degeneration | BMC...
As a part of the three-column structure of vertebrae, facet joints play a key role in maintaining the stability of spinal motion, particularly in the lumbar area . Therefore, most doctors are concerned with the biomechanical and mechanical factors affecting lumbar facet joints. However, the pathogenesis of FJOA has not been fully elucidated. Accordingly, in this study, we evaluated the expression of adiponectin in lumbar facet joints. Our results showed that adiponectin expression was significantly downregulated with increasing degeneration of the lumbar facet joint.. Adiponectin is an adipocyte factor specifically secreted from fat cells. Adiponectin is composed of 244 amino acids; the N-terminus contains one secretory signal sequence, and the C-terminus contains a spherical egg white function threshold. Previous studies have shown that adiponectin is involved in glucose homeostasis, insulin sensitivity, and vascular inflammatory diseases [25, 26]. Adiponectin in human peripheral blood ...
Adiponectin and leptin in overweight/obese and lean women with polycystic ovary syndrome<...
TY - JOUR. T1 - Adiponectin and leptin in overweight/obese and lean women with polycystic ovary syndrome. AU - Chen, Chin I.. AU - Hsu, Ming-I. AU - Lin, Shyh-Hsiang. AU - Chang, Yuan Chin Ivan. AU - Hsu, Chun-Sen. AU - Tzeng, Chii-Ruey. PY - 2015/4/1. Y1 - 2015/4/1. N2 - Aim: The objective of this study was to evaluate the adiponectin and leptin levels in overweight/obese and lean women with polycystic ovary syndrome (PCOS). Design: This was a retrospective study. Patients: Of the 422 studied patients, 224 women with PCOS and 198 women without PCOS were evaluated. Main outcome measure(s): Insulin resistance and the metabolic components were assessed. The adiponectin and leptin levels were also evaluated. Results: Adiponectin was negatively correlated with insulin resistance, body mass index (BMI), and total testosterone, triglyceride, and low-density lipoprotein (LDL) levels; conversely, leptin reversed the aforementioned reaction and was negatively correlated with adiponectin levels. The ...
Dynamic alteration of adiponectin/adiponectin receptor expression and by Yanzhuo Ma, Yi Liu et al.
The present study determined the dynamic change of adiponectin (APN, a cardioprotective adipokine), its receptor expression, and their impact upon myocardial ischemia/reperfusion (MI/R) injury during type 1 diabetes mellitus (T1DM) progression, and involved underlying mechanisms. Diabetic state was induced in mice via multiple intraperitoneal injections of low-dose streptozotocin. The dynamic change of plasma APN concentration and cardiac APN receptor-1 and -2 (AdipoR1/2) expression were assessed immediately after diabetes onset (0 wk) and 1, 3, 5, and 7 wk thereafter. Indicators of MI/R injury (infarct size, apoptosis, and LDH release) were determined at 0, 1, and 7 wk of DM duration. The effect of APN on MI/R injury was determined in mice subjected to different diabetic durations. Plasma APN levels (total and HMW form) increased, whereas cardiac AdipoR1 expression decreased early after T1DM onset. With T1DM progression, APN levels were reduced and cardiac AdipoR1 expression increased. MI/R injury was
Recombinant Adiponectin Receptor 1 (ADIPOR1), Cat#RPU40113 - Biomatik
Biomatik provides products of ELISA Kits, Antibodies, Proteins, Biochemicals & Enzymes. Also, we deal with the services of Gene Synthesis, Peptide Synthesis, Protein Expression at affordable charges.
Adiponectin levels, insulin resistance and their relationship with serum levels of inflammatory cytokines in patients with...
Aim Increased frequency of cardiovascular disease and its possible relations with insulin resistance have been reported in patients with inflammatory diseases. The aim of our study was to investigate insulin resistance and serum adiponectin levels as cardiovascular risk markers in patients with Behçets disease.. Method Study population consisted of 40 patients with Behçets disease (BD) and a control group composed of age, gender, body mass index-matched 46 healthy individuals. All patients were examined for signs of Behçets disease. Body mass index, waist and hip circumference were measured. Insulin resistance was evaluated using the homeostasis model assessment-insulin resistance method. Erythrocyte sedimentation rate (ESR), lipid profile, high sensitive CRP (hsCRP), adiponectin, TNF-α, IL-6 and IL-8 levels were measured.. Results Erythrocyte sedimentation rate, serum hsCRP and IL-6 levels were significantly higher in patients with BD than those in the controls (P = 0.001, P = 0.001, P = ...
Adiponectin and adiponectin receptor 1 overexpression enhance inflammatory bowel disease | Journal of Biomedical Science | Full...
Adiponectin (ADN) is an adipokine derived from adipocytes. It binds to adiponectin receptor 1 and 2 (AdipoR1 and R2) to exert its function in regulating whole-body energy homeostasis and inflammatory responses. However, the role of ADN-AdipoR1 signaling in intestinal inflammation is controversial, and its role in the regulation of neutrophils is still unclear. Our goal was to clarify the role of AdipoR1 signaling in colitis and the effects on neutrophils. We generated porcine AdipoR1 transgenic mice (pAdipoR1 mice) and induced murine colitis using dextran sulfate sodium (DSS) to study the potential role of AdipoR1 in inflammatory bowel disease. We also treated a THP-1 macrophage and a HT-29 colon epithelial cell line with ADN recombinant protein to study the effects of ADN on inflammation. After inducing murine colitis, pAdipoR1 mice developed more severe symptoms than wild-type (WT) mice. Treatment with ADN increased the expression of pro-inflammatory factors in THP-1 and HT-29 cells. Moreover, we also
Effect of Selenium on Serum Adiponectin, Homocystein and Malnutrition-inflammation Complex Syndrome in Hemodialysis Patients -...
After screening all of 280 patients under regular HD in Faghihi Hospital Hemodialysis Center, 80 stable patients in the age range of 18-80 years old were found to be eligible for enrollment and give their informed consent to participate in this trial.The Ethics Committee of Shiraz University of Medical Sciences reviewed and approved the protocol of this study.These patients are randomly assigned in a 1:1 ratio into 2 groups of selenium(200µg) or placebo and followed for 12 weeks.Before the onset of the treatment and after the end of the treatment phase of the study, 10cc blood samples were taken from each patient. The blood was taken from the patients arm used for hemodialysis cannulae just before the beginning of the HD session. The serum was separated by centrifugation at 3000 g/min for 5 min and stored at -70°C. Serum levels of adiponectin,high sensitive C-reactive protein (HSCRP), ferritin, transferrin, homocysteine, calcium, phosphate, albumin, blood urea nitrogen (BUN), and creatinine ...
TCDB » SEARCH
The adiponectin receptor 1 for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (Tanabe et al. 2015; Yamauchi et al. 2003. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. The 3-d structure revealed ceramidase activity for both ADIPOR1 and ADIPOR2; however, the two structures are substantially different (Vasiliauskaité-Brooks et al. 2017). It may function with adiponectin to stimulate cholesterol efflux via ABCA1 (Hafiane et al. 2019 ...
Hormone may protect against development of insulin resistance during weight gain | News | Research | Memorial University of...
Farrell Cahill, a PhD student under the supervision of Dr. Guang Sun in the Faculty of Medicine, has discovered evidence that may shed new light on how the hormone adiponectin may aid in the attenuation of insulin resistance development during weight gain. The study, titled Short-term Overfeeding Increases Circulating Adiponectin Independent of Obesity Status, was published in the peer-reviewed journal PLOS ONE on Aug. 30.. Insulin resistance comprises about 90 per cent of all diabetic cases and has become an ever increasing health-care challenge with a significant fiscal burden, said Mr. Cahill. This is especially relevant to Newfoundland and Labrador considering it has one the highest rates of diabetes and obesity in Canada. Mr. Cahill explained that the accumulation of white adipose tissue (WAT) is the product of a chronic positive energy balance in an obesogenic environment.. Numerous disorders such as insulin resistance have shown a strong association with the accumulation of fat mass. ...
TCDB » SEARCH
The adiponectin receptor 1 for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (Tanabe et al. 2015; Yamauchi et al. 2003. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. The 3-d structure revealed ceramidase activity for both ADIPOR1 and ADIPOR2; however, the two structures are substantially different (Vasiliauskaité-Brooks et al. 2017 ...
Serum from pregnant women with gestational diabetes mellitus increases the expression of FABP4 mRNA in primary subcutaneous...
Serum from pregnant women with gestational diabetes mellitus (GDM) increased the expression of fatty acid-binding protein 4 (FABP4) mRNA and decreased the expression of adiponectin mRNA in primary subcutaneous human pre-adipocytes. After primary human pre-adipocytes were cultured using serum from pregnant women with GDM and normal pregnant women for 24 hours, real-time polymerase chain reaction and Western blot was performed. (A) Expression of FABP4 mRNA in adipocytes cultured in serum from pregnant women with GDM was higher than that from the normal group. (B) Expression of adiponectin mRNA in adipocytes cultured in serum from mothers with GDM was lower than that from the normal group. (C) FABP4 and adiponectin protein level in adipocyte were determined by Western blot (representative blots are shown). (D) Band densities in the Western blot were quantified using ImageJ software. Trends toward increased FABP4 protein expression and decreased adiponectin protein expression in GDM group were ...
Diabetology of Pregnancy (Frontiers in Diabetes) by J. Djelmiš, G. Desoye, M. Ivaniševic, M. Porta, F.M. - TravelMate...
Adiponectin concentrations were protective against DM2 . In humans plasma adiponectin was found to be associated with skeletal muscle insulin receptor tyrosine phosphorylation. In pregnant women a decrease of adiponectin was shown with increasing insulin resistance in the third trimester and a further decrease in women with IGT or GDM compared to pregnant women with NT even after adjustment for varying degrees of adiposity . In parallel decreased adiponectin mRNA levels were found in abdominal subcutaneous adipose tissue biopsies from women with GDM. Under normal conditions, during early pregnancy, basal glucose and insulin concentrations do not differ from nongravid values , and hepatic gluconeogenesis is unchanged . However, during late pregnancy the mother tends to develop hypoglycemia, which is especially evident during fasting. Indirect studies in women  and direct experiments in rats  have shown that the rate of gluconeogenesis is enhanced during pregnancy under ...
Reya Lab | Identification of Adiponectin As a Novel Hematopoietic Stem Cell Growth Factor
Journal of Immunology. 178(6):3511-3520. PubMed , PDF , ABSTRACT. The hemopoietic microenvironment consists of a diverse repertoire of cells capable of providing signals that influence hemopoietic stem cell function. Although the role of osteoblasts and vascular endothelial cells has recently been characterized, the function of the most abundant cell type in the bone marrow, the adipocyte, is less defined. Given the emergence of a growing number of adipokines, it is possible that these factors may also play a role in regulating hematopoiesis. Here, we investigated the role of adiponectin, a secreted molecule derived from adipocytes, in hemopoietic stem cell (HSC) function. We show that adiponectin is expressed by components of the HSC niche and its receptors AdipoR1 and AdipoR2 are expressed by HSCs. At a functional level, adiponectin influences HSCs by increasing their proliferation, while retaining the cells in a functionally immature state as determined by in vitro and in vivo assays. We ...
Single nucleotide polymorphism rs3774261 in the AdipoQ gene is associated with the risk of coronary heart disease (CHD) in...
Coronary Heart Disease (CHD) is one of the leading causes of death in the world with a projected global 82 million DALYs by 2020. Genetic and environmental factors contribute to CHD development. Here, the authors investigate the association between CHD risk and three Single Nucleotide Polymorphisms (SNPs) in the AdipoQ gene (rs3774261, rs1063537 and rs2082940); and the interaction of this association with environmental factors, in Northeast Han Chinese population. Using a case-control study design, 1514 participants (754 cases and 760 controls) were investigated. Three variants in the AdipoQ gene (rs3774261, rs1063537 and rs2082940) were selected and genotyped. The online SNPstats program and SPSS 21.0 software were used for data analyses. The authors found that the rs3774261G allele is associated with the risk of CHD but that the rs2082940T allele protects against CHD. No significant association was found between rs1063537 and CHD risk. The study also found significant interactions between triglyceride
Adiponectin Receptor Detection: Antibodies
Binding of adiponectin to ADIPOR1 results in activation of an AMP-dependent kinase (AMPK) signaling pathway that regulates fatty acid oxidation and insulin sensitivity. ADIPOR1 is also known as progestin and adipoQ receptor family member I (PAQR1), CGI45, ACDCR1, and TESBP1A.. Binding of adiponectin to ADIPOR2 mediates increased AMP-activated protein kinase (AMPK) activity, peroxisome proliferator-activated receptor-alpha (PPAR-alpha) ligand activity, fatty acid oxidation, and glucose uptake. ADIPOR2 is also known as progestin and adipoQ receptor family member II (PAQR2), and ACDCR2. ...
Adiponectin Receptor Detection: Antibodies
Binding of adiponectin to ADIPOR1 results in activation of an AMP-dependent kinase (AMPK) signaling pathway that regulates fatty acid oxidation and insulin sensitivity. ADIPOR1 is also known as progestin and adipoQ receptor family member I (PAQR1), CGI45, ACDCR1, and TESBP1A.. Binding of adiponectin to ADIPOR2 mediates increased AMP-activated protein kinase (AMPK) activity, peroxisome proliferator-activated receptor-alpha (PPAR-alpha) ligand activity, fatty acid oxidation, and glucose uptake. ADIPOR2 is also known as progestin and adipoQ receptor family member II (PAQR2), and ACDCR2. ...
Green Tea Extract and Catechol-O-Methyltransferase Genotype Modify Fasting Serum Insulin and Plasma Adiponectin Concentrations...
Decaffeinated GTE was not associated with reductions in body weight, BMI, or WC and did not alter energy intake or mean hormone concentrations in healthy postmenopausal women over 12 mo. GTE decreased fasting insulin concentrations in those with elevated baseline fasting concentrations. The high-act …
Adiponectin and negative mood in healthy premenopausal and postmenopausal women<...
TY - JOUR. T1 - Adiponectin and negative mood in healthy premenopausal and postmenopausal women. AU - Adam, Tanja. AU - Schamarek, Imke. AU - Springer, Elizabeth A.. AU - Havel, Peter J. AU - Epel, Elissa E.. PY - 2010/11. Y1 - 2010/11. N2 - Negative mood and stress are associated with cardiovascular and metabolic disease. There are likely many physiological mechanisms underlying the poor health outcomes. The relationship of psychological states (negative mood, life stress, and stress-responsive hormones) and adiponectin, an adipokine that promotes insulin sensitivity, was investigated in two separate studies. The two groups of participants included 52 healthy, premenopausal women, and 63 postmenopausal women with a range of stress levels. The relationship between adiponectin and psychological state (perceived stress and negative mood) was examined cross-sectionally in both groups of participants, but also prospectively (1 year later) in the group of postmenopausal women. In premenopausal women, ...
The Multi-Level Action of Fatty Acids on Adiponectin Production by Fat Cells
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
High-molecular-weight adiponectin and anthropometric variables among elementary schoolchildren: a population-based cross...
In the present study, HMW-adn and HMW-adn/T-adn were negatively correlated with anthropometric variables (BMI, %BF, WC, and WHtR). Furthermore, only WHtR was significantly or marginally significantly correlated with HMW-adn or HMW-adn/T-adn regardless of sex and physique. To the best of our knowledge, this study is the first study regarding the relationship between HMW-adn or HMW-adn/T-adn and anthropometric variables among over 1600 population-based elementary schoolchildren in Japan, where blood collection and the measurement of %BF and WC are not commonly performed in the annual health examination at elementary schools.. In this study, statistically significant differences between boys and girls were found in most anthropometric variables (Table 1). For example, %BF among boys was higher than that among girls in the present study, which was consistent with other study results conducted among Japanese children 9-10 years of age [15, 16]. A previous study showed that sexual differences in body ...
Hope for Those with Diabetic Periodontal Disease
Almost half of adults over age 30 in the United States have periodontal disease. In most cases, a few visits to the dentist take care of the problem. In patients with Type 2 diabetes, however, gum disease is extremely difficult to treat, because systemic inflammation can cause it to spread unchecked, leading to tooth loss and massive erosion of jawbone.. Diabetic patients have a much higher chance of developing periodontitis than the rest of the population, and when they do get it, its very difficult to handle, said Jake Jinkun Chen, a professor and molecular biologist at Tufts School of Dental Medicine whose lab studies diabetes-associated periodontal disease. The lab is exploring a promising new way to treat resistant cases with an experimental drug that mimics the behavior of the hormone adiponectin in the body; adiponectin helps regulate glucose levels as well as the breakdown of fatty acids.. Produced by fat cells, adiponectin can signal the body to generate more bone in areas where it ...
Background: Obesity is a significant risk factor for the development of endometrial cancer (EC). Epidemiological studies indicate that adiponectin is significantly decreased in the obese woman and in women with EC. Adiponectin is an insulin-sensitizing, anti-inflammatory cytokine produced in adipose that has pleiotropic effects on numerous physiologic processes and peripheral tissues. In normal metabolic tissues, adiponectin acts through the adiponectin receptor 1 (AdipoR1) to activate the AMPK pathway. Adiponectin stimulates AMPK by promoting the formation of AdipoR1-APPL1 complexes. APPL2 antagonizes AdipoR1 signaling by blocking the formation of these complexes. AdipoR1-APPL1 complexes activate AMPK signaling which can negatively regulate the mTOR pathway, an important contributor to the development of endometrial complex atypical hyperplasia (CAH) and EC, to inhibit protein synthesis and cell growth during times of cellular starvation. The goal of these studies was to assess adiponectin ...
Adiponectin receptor signaling on dendritic cells blunts antitumor immunity. - Nuffield Department of Surgical Sciences
Immune escape is a fundamental trait of cancer. Dendritic cells (DC) that interact with T cells represent a crucial site for the development of tolerance to tumor antigens, but there remains incomplete knowledge about how DC-tolerizing signals evolve during tumorigenesis. In this study, we show that DCs isolated from patients with metastatic or locally advanced breast cancer express high levels of the adiponectin receptors AdipoR1 and AdipoR2, which are sufficient to blunt antitumor immunity. Mechanistic investigations of ligand-receptor interactions on DCs revealed novel signaling pathways for each receptor. AdipoR1 stimulated IL10 production by activating the AMPK and MAPKp38 pathways, whereas AdipoR2 modified inflammatory processes by activating the COX-2 and PPARγ pathways. Stimulation of these pathways was sufficient to block activation of NF-κB in DC, thereby attenuating their ability to stimulate antigen-specific T-cell responses. Together, our findings reveal novel insights into how DC
Adiponectin Receptor Type 1 (Adipo R1) (357-375) (Human) - Biotin Labeled Purified IgG
Adiponectin is a fat tissue-derived adipokine with beneficial effects against diabetes, cardiovascular diseases, and cancer. Accordingly, adiponectin-mimetic molecules possess significant pharmacological potential. Oligomeric states of adiponectin appear to determine its biological activity. We identified a highly conserved, 13-residue segment (ADP-1) from adiponectins collagen domain which comprises GXXG motifs and has one asparagine and two histidine residues that assist in oligomeric protein assembly. We therefore hypothesized that ADP-1 promotes oligomeric assembly and thereby mediates potential metabolic effects. We observed here that ADP-1 is stable in human serum and oligomerizes in aqueous environments. We also found that ADP-1 activates AMP-activated protein kinase (AMPK) in an adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1)-dependent pathway and stimulates glucose uptake in rat skeletal muscle cells (L-6 myotubes). ADP-1-induced glucose ...
Adiponectin/resistin levels and insulin resistance in children: a four country comparison study | International Journal of...
There are few reports on the effects of ethnicity or gender in the association between adipocytokines and insulin resistance in children of different ages. This study assessed associations between serum concentrations of adiponectin/resistin and parameters of insulin resistance in children from 4 different countries. A total of 2,290 children were analyzed in this study; each was from one of 4 different countries (Japan, Thailand, Italy and USA), and grouped according to age (8-11 years old in Group 1 and 12-15 years old in Group 2). Adioponectin was higher in female than in male children, and in Group 1 than in Group 2. Generally, adiponectin was lower in Asian as compared to Italian and American children. These tendencies remained even after adjustment for body mass index (BMI) or waist circumstance (WC). Among older children (Group 2), resistin was higher in female than in male children. Significant correlations by non-parametric univariate correlation coefficients and Spearmans rank correlation
The combined effect of adiponectin and resistin on all-cause mortality in patients with type 2 diabetes: Evidence of synergism...
BACKGROUND AND AIMS While elevated serum adiponectin and resistin levels have been singly associated with all-cause mortality in patients with type 2 diabetes (T2D), their combined effect has never been studied. We investigated such joint effect in patients with T2D and its possible modulation by several demographic and clinical conditions, known to affect per se mortality rate. METHODS Patients with T2D from the Gargano Mortality Study (GMS; N = 895, follow-up = 10.5 ± 3.7 years; 290 events) and the Foggia Mortality Study (FMS; N = 519, follow-up = 7.1 ± 2.5 years; 140 events) were examined. RESULTS As singly considered, adiponectin and resistin were independently associated with mortality rate in GMS and FMS (p | 0.0001 for both). The two studies were then pooled, for investigating the nature of the joint effect of the two adipokines. In such sample, both adipokines were associated with death, independent of each other and of several additional covariates (p = 0.01-4.58 × 10(-12)). Of note, no
Rat ADIPOR1(Adiponectin Receptor 1) ELISA Kit - Signet Laboratories
The microtiter plate provided in this kit has been pre-coated with an antibody specific to Adiponectin Receptor 1 (ADIPOR1). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to ...
Daily Dose Of Fish Oil May Reduce Risk Of Diabetes, Heart Disease - Redorbit
redOrbit Staff & Wire Reports - Your Universe Online. The use of fish oil supplements has been linked to a moderate increase in production of a hormone that has in turn been associated with a decreased risk of some forms of diabetes and heart disease, researchers from the Harvard School of Public Health (HSPH) report in a new study.. The supplements, which are also known as omega-3 fatty acid capsules, increase levels of the hormone adiponectin in a patient´s bloodstream. According to the researchers, adiponectin has a key role in several metabolic processes, including glucose regulation and modulation of inflammation; and long-term human studies have found a correlation between higher levels of the hormone and a reduced risk of Type 2 diabetes and coronary heart disease.. While prior animal studies found fish oil increased circulating adiponectin, whether similar effects apply in humans is not established, lead author Jason Wu, a research associate in the university´s epidemiology ...
Women Health: Rosiglitazone treatment increases plasma levels of adiponectin and decreases levels of resistin in overweight...
In a randomised placebo-controlled study of thirty overweight/obese women with PCOS (body mass index>25 kg/m(2), mean age 29.1+/- 1.2 (S.E.M.) years) randomly allocated to either rosiglitazone (Avandia, 4 mg twice a day) or placebo treatment and to assess of plasma levels of adiponectin, resistin and ghrelin and their correlation to serum levels of insulin, C-peptide and steroid hormones, and insulin sensitivity (euglycaemic hyperinsulinaemic clamp), posted in PubMed, found that Rosiglitazone had beneficial effects on serum levels of adiponectin and resistin, suggesting that these adipocytokines may contribute to the improvement in insulin sensitivity observed during the treatment ...
List of OMIM disorder codes
ADSL Adiponectin deficiency; 612556; ADIPOQ Adrenal cortical carcinoma; 202300; TP53 Adrenal hyperplasia, congenital, due to 11 ...
Research focusing on adiponectin (ADPN) has yielded positive results in the development of possible treatments for ... Rizzo, Maria Rosaria; Fasano, Renata; Paolisso, Giuseppe (2020). "Adiponectin and Cognitive Decline". International Journal of ...
... small-molecule agonist of the adiponectin receptors to be identified. Adiponectin receptor agonists such as AdipoRon have ... Dysregulation of adiponectin expression has also been implicated in the pathology of mood disorders, anxiety disorders, eating ... As such, adiponectin receptor agonists are a highly interesting therapeutic target for a variety of different conditions. ... In addition, adiponectin has recently been elucidated to mediate the antidepressant, anxiolytic, and neurogenic effects of ...
Biomarkers of diabetes
Regulating cytokines like leptin and adiponectin. OXT decreased fat mass, resulting in reduction in leptin level. Oxytocin may ... and late-onset obesity with increases in abdominal fats and fasting plasma triglycerides The balance of leptin and adiponectin ... cross-sectional evaluation of baseline circulating levels of the novel hormone Irisin and the established adipokine adiponectin ...
... has been identified as a novel protein involved in the regulation of adiponectin trafficking and release from the ... RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte ... potentially contributing to lower circulating levels of adiponectin observed in obese populations. RAB11FIP1 has been shown to ... "The Rab11 Effector Protein FIP1 Regulates Adiponectin". PLOS ONE. 8 (9): e74687. doi:10.1371/journal.pone.0074687. PMC 3770573 ...
A negative regulator of adiponectin gene expression". J. Biol. Chem. 281 (42): 31245-53. doi:10.1074/jbc.M605132200. PMID ...
October 2010). "Adiponectin lowers glucose production by increasing SOGA". Am. J. Pathol. 177 (4): 1936-45. doi:10.2353/ajpath. ...
Brown adipose tissue
... and they have higher circulating adiponectin, suggesting a link between longevity and adiponectin production. In addition, high ... Brown adipose tissue activation through cold exposure increases adiponectin levels, just two hours of cold exposure resulted in ... Centenarians (both men and women) and their offspring have been found to have genetics that boost adiponectin, ... Imbeault, Pascal; Dépault, Isabelle; Haman, François (2009-04-01). "Cold exposure increases adiponectin levels in men". ...
Adiponectin: is a type of protein secreted by adipose cells that improves insulin sensitivity and possesses antiatherogenic ... Lower levels of s-adiponectin are associated with ischemic stroke. Aging: the prevalence of silent stroke rises with increasing ... Bang, OY; Saver, JL; Ovbiagele, B; Choi, YJ; Yoon, SR; Lee, KH (2007). "Adiponectin levels in patients with intracranial ...
Stumvoll M, Häring H (November 2002). "Resistin and adiponectin--of mice and men". Obes. Res. 10 (11): 1197-9. doi:10.1038/oby. ... Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ (October 2003). "Plasma resistin, adiponectin and leptin levels ... Milan G, Granzotto M, Scarda A, Calcagno A, Pagano C, Federspil G, Vettor R (November 2002). "Resistin and adiponectin ... Wulster-Radcliffe MC, Ajuwon KM, Wang J, Christian JA, Spurlock ME (April 2004). "Adiponectin differentially regulates ...
... can inhibit mTORC1 in the liver and stimulate adiponectin secretion from fatty tissues, thereby inhibiting aging- ... FGF21 induces the insulin-sensitizing hormone adiponectin. FGF21 treatment of adipocytes is associated with phosphorylation of ... improved serum lipid profile and adiponectin levels, with no effect on HbA1c. xSubcutaneous treatment of obese, diabetic ... reduce overweight and improve plasma lipid profile while increasing circulating adiponectin. Serum FGF21 levels are ...
Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor ... Agonist of the adiponectin receptor 2 (AdipoR2). Inhibition of mammalian thioredoxin reductase Onozato, Thelma; Nakamura, Celso ... Adiponectin receptor agonists, Epoxides, Histone deacetylase inhibitors, Sesquiterpene lactones). ...
Caloric restriction mimetic
Adiponectin (together with leptin, it regulates adipose tissue metabolism. It is activated by PPAR inhibitors such as ... It also blocks the beneficial actions of adiponectin. Rimonabant inhibits these and so it reduces appetite, balances energy, ... and increases adiponectin, which reduces intra-abdominal fat. It improves lipid profile, glucose tolerance, and waist ...
Non-alcoholic fatty liver disease
Adiponectin has several properties that protect the liver. These properties include improved liver fat metabolism, decreased de ... Adipose tissue dysfunction also decreases secretion of the insulin-sensitizing adipokine adiponectin in people with NAFLD. ...
Adiponectin has also been shown to increase the rate of fatty acid transport and oxidation in mice, which causes an increase in ... The adiponectin genes regulate glucose metabolism as well as fatty acid breakdown; however, the exact mechanisms are not ... Therefore, there was less adiponectin to help cells take up glucose and break down fat, as well as less leptin to cause a ... With a high fat diet during gestation, there was an increase in methylation in the promoter of the adiponectin gene accompanied ...
Fast protein liquid chromatography
"Isolation and quantitation of adiponectin higher order complexes". Methods in Enzymology. Methods of Adipose Tissue Biology, ...
Research into centenarians
It is believed that centenarians possess a different adiponectin isoform pattern and have a favorable metabolic phenotype in ... "Assessment of adiponectin and its isoforms in Polish centenarians". Experimental Gerontology. 48 (4): 401-407. doi:10.1016/j. ...
February 2010). "Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype". The Journal of Biological ...
Japanese scientific misconduct allegations
The Nature paper, which allegedly identified the adiponectin receptors AdipoR1 and AdipoR2 by expression cloning using FACS, ... "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762-769. Bibcode:2003Natur. ... Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 431 (7012): 1123. doi:10.1038/ ...
G protein-coupled receptor
June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762-9. Bibcode: ... such as microbial rhodopsins and adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2). However, these 7TMH (7-transmembrane ...
Jardé T, Perrier S, Vasson MP, Caldefie-Chézet F (January 2011). "Molecular mechanisms of leptin and adiponectin in breast ...
Adiponectin induces reverse cholesterol transport by an ABCA1-dependent pathway. Other endogenous metabolites more loosely ... Hafiane A, Gasbarrino K, Daskalopoulou SS (November 2019). "The role of adiponectin in cholesterol efflux and HDL biogenesis ...
Sp7 transcription factor
Adiponectin is a protein hormone that has been shown to be upregulated in rheumatoid arthritis disease pathology, causing the ... In primary human cell cultures Sp7 was shown to be inhibited by adiponectin thus contributing downregulation of the creation of ... May 2017). "Response of human rheumatoid arthritis osteoblasts and osteoclasts to adiponectin". Clinical and Experimental ...
"In vitro and in vivo effects of adiponectin on bone." Endocrinology 150, no. 8 (2009): 3603-3610. Naot, Dorit, Andrew Grey, Ian ...
It also inhibits lipolysis and stimulates the secretion of adiponectin. These effects are thought to be mostly conferred via ... July 2011). "Orexin A stimulates glucose uptake, lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and ...
Bone marrow adipose tissue
WAT is also the source of adipokines and inflammatory markers which have both positive (e.g., adiponectin) and negative effects ... Ye R, Scherer PE (April 2013). "Adiponectin, driver or passenger on the road to insulin sensitivity?". Molecular Metabolism. 2 ... Recently, BMAT was noted to "produce a greater proportion of adiponectin - an adipokine associated with improved metabolism - ... August 2014). "Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during ...
"Essential role of mitochondrial function in adiponectin synthesis in adipocytes". Diabetes. 56 (12): 2973-81. doi:10.2337/db07- ...
But adiponectin, an anti-inflammatory adipokine, which is found in lower concentration in obese and diabetic individuals has ... August 2015). "Adiponectin as a Protective Factor Against the Progression Toward Type 2 Diabetes Mellitus in Postmenopausal ... Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ (October 2003). "Plasma resistin, adiponectin and leptin levels ... June 2004). "Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity". Obesity Research ...
Ghoshal, K; Bhattacharyya, M (2015). "Adiponectin: Probe of the molecular paradigm associating diabetes and obesity". World J ... Ghoshal, K., & Bhattacharyya, M. (2015). Adiponectin: Probe of the molecular paradigm associating diabetes and obesity. World ...
... and adiponectin". Peptides. 27 (4): 911-6. doi:10.1016/j.peptides.2005.12.014. PMID 16476508. Steckelings, U; Kaschina, E; ...
Adiponectin receptors | The Scientist Magazine®
Adiponectin is a circulating protein, the serum level of which is decreased in obesity and diabetes and in patients with ... Adiponectin receptors. Novel proteins controlling metabolism could lead to a new treatment for diabetes. Cathy Holding(cholding ... Toshimasa Yamauchi and colleagues at the University of Tokyo report the cloning of two separate adiponectin receptors, one from ... The protein enhances insulin sensitivity by improving glucose and lipid metabolism, suggesting that adiponectin may have a role ...
Niacin stimulates adiponectin secretion through the GPR109A receptor
... has recently been shown to increase serum adiponectin concentrations in men with the metabolic syndrome. However, little is ... known about the mechanism(s) by which niacin regulates the intracellular trafficking and secretion of adiponectin. Since niacin ... Niacin stimulates adiponectin secretion through the GPR109A receptor Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E549-58. ... and serum was obtained for the determination of adiponectin and NEFA concentrations. Serum adiponectin concentrations increased ...
Recombinant Mouse Adiponectin protein (ab285685) | Abcam
Recombinant Mouse Adiponectin protein is an Escherichia coli Full length protein, , 90% purity, , 1.000 Eu/µg endotoxin level ... Defects in ADIPOQ are the cause of adiponectin deficiency (ADPND) [MIM:612556]. ADPND results in very low concentrations of ... Hydroxylation and glycosylation of the lysine residues within the collagene-like domain of adiponectin seem to be critically ... This product is manufactured by BioVision, an Abcam company and was previously called 4902 Adiponectin, murine recombinant. ...
Browsing by Subject "Adiponectin"
Adiponectin has profound insulin-sensitizing, anti-inflammatory and anti-atherogenic effects. However, reports of the role of ... Associations between single-nucleotide polymorphisms of ADIPOQ, serum adiponectin and increased type 2 diabetes mellitus risk ... genotypes and investigate the association between the two SNPs and adiponectin concentration, metabolic parameters and risk of ... adiponectin in pre-eclampsia are conflicting. This study in Egypt investigated the association ... ...
Evaluation of multiplex immunoassays, used for determination of adiponectin, resistin, leptin, and ghrelin from human blood...
Adiponectin Testing Market - Talk to Analyst | Future Market Insights
Adiponectin in Youth | Diabetes Care | American Diabetes Association
1) in this issue of Diabetes Care regarding adiponectin in youth. We are excited to have received the opinion of in ... 0.02 with adiponectin and insulin sensitivity in the formula; R2 = 0.162, P = 0.007 with only adiponectin in the formula). Also ... Adiponectin in Youth: Response to Stefan et al. Fida Bacha, MD; Fida Bacha, MD ... Fida Bacha, Rola Saad, Neslihan Gungor, Silva A. Arslanian; Adiponectin in Youth: Response to Stefan et al.. Diabetes Care 1 ...
Adiponectin Human HEK293 | BioVendor R&D
Recombinant human Adiponectin is expressed in HEK293.Tested applications are: Cell culture and/or animal studies, ELISA, ... Adiponectin. By Technical Data. Adiponectin - Proteins. Adiponectin - Recombinant protein - Proteins. Human - Adiponectin - ... Adiponectin - for Western blotting - Proteins. Adiponectin - for ELISA - Proteins. Adiponectin - for Cell culture and/or animal ... References to Adiponectin. *Lam KS, Xu A. Adiponectin: protection of the endothelium. Curr Diab Rep. 2005, 5, 254-259. ...
Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology<...
Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. In: American Journal of Human Genetics. 2019 ... Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. American Journal of Human Genetics. 2019;105 ... Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. Cassandra N. Spracklen, Tugce Karaderi, ... Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. / Spracklen, Cassandra N.; Karaderi, Tugce; ...
WHO EMRO | Adiponectin levels in serum of women with pre-eclampsia | Volume 17, issue 7 | EMHJ volume 17, 2011
This study in Egypt investigated the association between serum adiponectin levels and pre-eclampsia and between adiponectin ... Serum adiponectin levels in pre-eclamptic women were significantly higher than in normal pregnant women and the increase was ... The results support the theory that adiponectin might be part of a feedback mechanism improving insulin sensitivity and ... There was a significant negative correlation between adiponectin levels and arterial blood pressure in all groups. However, ...
Effects of habitual t'ai chi exercise on adiponectin, glucose homeostasis, lipid profile, and atherosclerotic burden in...
... ai chi exercise on adiponectin, glucose homeostasis, lipid profile, and atherosclerotic burden in individuals with ... Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and ... Adiponectin and atherosclerosis risk factors in African hemodialysis patients: a population at low risk for atherosclerotic ... Beneficial Effects of Adiponectin on Glucose and Lipid Metabolism and Atherosclerotic Progression: Mechanisms and Perspectives ...
Exploration of inflammation, oxidative stress, adiponectin and intestinal flora in patients with hepatitis B, liver cirrhosis...
... adiponectin and intestinal flora in patients with hepatitis B, liver cirrhosis and hepatocellular carcinoma - Minerva ... Xu J, Liu K, Ma Z, Lin Y, Pang L. Exploration of inflammation, oxidative stress, adiponectin and intestinal flora in patients ... Exploration of inflammation, oxidative stress, adiponectin and intestinal flora in patients with hepatitis B, liver cirrhosis ...
Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in nonobese...
Chan, D., Watts, G., Ooi, E., Chan, D. T., Wong, A. T. Y., & Barrett, H. (2011). Apolipoprotein A-II and adiponectin as ... Chan, D, Watts, G, Ooi, E, Chan, DT, Wong, ATY & Barrett, H 2011, Apolipoprotein A-II and adiponectin as determinants of very ... T1 - Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in ... Apolipoprotein A-II and adiponectin as determinants of very low-density lipoprotein apolipoprotein B-100 metabolism in nonobese ...
Relations of plasma total and high-molecular-weight adiponectin to new-onset heart failure in adults ≥65 years of age (from the...
Results were similar for HMW adiponectin. In conclusion, total and HMW adiponectin showed comparable relations with incident HF ... Results were similar for HMW adiponectin. In conclusion, total and HMW adiponectin showed comparable relations with incident HF ... Results were similar for HMW adiponectin. In conclusion, total and HMW adiponectin showed comparable relations with incident HF ... Results were similar for HMW adiponectin. In conclusion, total and HMW adiponectin showed comparable relations with incident HF ...
Exercise training is not associated with improved levels of C-reactive protein or adiponectin<...
Exercise training is not associated with improved levels of C-reactive protein or adiponectin. In: Metabolism: Clinical and ... Exercise training is not associated with improved levels of C-reactive protein or adiponectin. / Marcell, Taylor J.; McAuley, ... Dive into the research topics of Exercise training is not associated with improved levels of C-reactive protein or adiponectin ... Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism: Clinical and ...
Can't lose weight? Maybe it's your Adiponectin Levels? - Susan B. Dopart
My what? What exactly is Adiponectin?. Adiponectin is a protein that is related to how well you metabolize fat and even your ... The accumulation of abdominal fat can be associated with a decline in adiponectin. Adiponectin is produced by the bodys fat ... Cant lose weight? Maybe its your Adiponectin Levels?. Susan Dopart Exercise, Get Moving!, Great Idea!, Health and Lifestyle, ... One study showed adiponectin levels rose 260% after 2-3 bouts of exercise and stayed elevated for a few weeks. Another study ...
Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents - WRAP: Warwick Research Archive...
2006) Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. Atherosclerosis, Volume 189 ( ... Circulating levels of adiponectin (AD), plasminogen activator inhibitor I (PAI-1), interleukin 18 (IL-18), C-reactive protein ( ... Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents ...
Serum leptin, resistin, visfatin and adiponectin levels in tumour necrosis factor receptor-associated periodic syndrome (TRAPS)...
Objectives: The aims of our study were to evaluate serum leptin, resistin, visfatin and adiponectin levels in patients with ... N2 - Objectives: The aims of our study were to evaluate serum leptin, resistin, visfatin and adiponectin levels in patients ... AB - Objectives: The aims of our study were to evaluate serum leptin, resistin, visfatin and adiponectin levels in patients ... Dive into the research topics of Serum leptin, resistin, visfatin and adiponectin levels in tumour necrosis factor receptor- ...
An adiponectin-S1P axis protects against lipid induced insulin resistance and cardiomyocyte cell death via reduction of...
Our data establish adiponectin signaling-mediated increase in S1P secretion as a mechanism via which HFD or PA induced ... 6-week-old male adiponectin knock out (Ad-KO) mice were fed chow or 60% HFD for 6 weeks then received saline or recombinant ... This study investigated the mechanisms of adiponectin action in the heart during high fat diet (HFD) feeding or in palmitate ( ... H9c2 cardiomyocytes were treated ±0.1 mM PA, the adiponectin receptor agonist AdipoRon, or the antioxidant MnTBAP then assays ...
Adiponectin as predictor for diabetes among pre-diabetic groups - Fingerprint - Yonsei University
Leptin, Adiponectin, and Heart Rate Variability Among Police Officers
Adiponectin Adiposity Adult Aged Body Mass Index Cross-Sectional Studies Female Heart Rate Humans Leptin Male Middle Aged ... Leptin, but not adiponectin, was significantly and inversely associated with HRV. Body mass index (BMI) and percent body fat ... Leptin and adiponectin may be related to CVD health. Therefore, our objective was to investigate the relationship between these ... Leptin and adiponectin levels were measured in 388 officers from the Buffalo Cardio-Metabolic Occupational Police Stress study ...
Pathogenesis of bone disease in multiple myeloma: from bench to bedside | Blood Cancer Journal
Adiponectin. Adiponectin constitutes an adipocyte-derived hormone that is also expressed by osteoblasts and BMSCs. Both ... Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J. Cell. Biochem. 99, 196-208 ( ... Host-derived adiponectin is tumor-suppressive and a novel therapeutic target for multiple myeloma and the associated bone ... The direct pathway by circulating adiponectin is inhibitory, while all the others are stimulatory99. In a murine MM model, ...
adiponectin - Jobber Wiki
Raspberry Ketone | Adiponectin
... scientific and commercial benefits of the natural burner and Adiponectin ... Raspberry Ketone - the natural fat burner that lowers Adiponectin levels. Natalie Jay Weight Loss Articles ... In adults, levels of Adiponectin are inversely correlated with body fat percentage. This means people with more in their system ... Researchers theorize Raspberry Ketone causes the body to secret more Adiponectin, a protein hormone involved in metabolizing ( ...
Adiponectin - Pharmawiki.in
Adiponectin Archives - Diapharma
Adipose Tissue | Diabetes | American Diabetes Association
The adiponectin sensitivity index (SA) reflects the fraction of adiponectin found in the HMW form. This index has become ... Adiponectin-mediated weight gain can be augmented even further. If a more active version of adiponectin (a protein carrying a ... The curves for adiponectin and leptin double-null mice (Ad-/-Ob-/-, gray), obese adiponectin wild type-mice (Ad+/+Ob-/-, dashed ... The curves for adiponectin and leptin double-null mice (Ad-/-Ob-/-, gray), obese adiponectin wild type-mice (Ad+/+Ob-/-, dashed ...
Adiponectin through its biphasic serum level is a useful biomarker during transition from diastolic dysfunction to systolic...
Thereafter, adiponectin levels increased prior to occurrence of systolic dysfunction. Adiponectin concentration is inversely ... No difference for adiponectin distribution among visceral adipose tissues was found. Adiponectin through its biphasic serum ... Meanwhile, tissue and serum adiponectin decreased from 3 months and reached plateau until 12 months in parallel with decreasing ... as well as serum level and tissue expression of adiponectin were determined at the same time as echocardiography. The results ...
Adiponectin is associated with insulin sensitivity in white European men but not black African men<...
Adiponectin is associated with insulin sensitivity in white European men but not black African men. / Hakim, Olah; Bello, ... Adiponectin is associated with insulin sensitivity in white European men but not black African men. In: Diabetic Medicine. 2021 ... Adiponectin is associated with insulin sensitivity in white European men but not black African men. Diabetic Medicine. 2021 Mar ... title = "Adiponectin is associated with insulin sensitivity in white European men but not black African men", ...
LeptinReceptorsPlasma adiponectinADIPOQInsulin sensitivityAdipokinesMouse AdiponectinProteinRole of adiponectinExpression of adiponectinLevelsConcentrationsRecombinantCoronary arteryHormoneMetabolicAdiposeAdipocytesSecretion of adiponectinObesityCirculatingGlobular domainTotal adiponectinIncrease adiponectinELISA KitProteinsRegulatesAdipoR2DiabetesCorrelationReceptor 1 geneBiologically activeCollagen domainSystolic dysfunctionNegatively associatedGeneHomeostasisHigh-molecular weightCardiovascular diseasesFattyAnti-atherogenicMetabolismPlateletSecretory
- Objectives: The aims of our study were to evaluate serum leptin, resistin, visfatin and adiponectin levels in patients with tumour necrosis factor receptorassociated periodic syndrome (TRAPS), in comparison to healthy controls, and to correlate their levels to parameters of disease activity and/or severity. (elsevier.com)
- Methods: Serum leptin, resistin, visfatin and adiponectin levels were obtained from 14 TRAPS patients carrying mutations involving cysteine residues, from 16 TRAPS patients carrying other mutations, and from 16 healthy controls. (elsevier.com)
- Results: Serum leptin, resistin, visfatin and adiponectin did not significantly differ among the 3 groups. (elsevier.com)
- There is an increasing recognition that adipose tissue is an endocrine organ secreting a number of biologically active adipokines such as leptin, adiponectin, and tumor necrosis factor-α. (docksci.com)
- Furthermore, some of these molecules, such as leptin, PAI-1, and adiponectin, are known to contribute to the development of hypertension [ 9 , 13 , 14 ] ( Figure 1 ). (hindawi.com)
- Adipokines ( adiponectin and leptin ), full serum lipid , and inflammatory factors [ white blood cell counts, C-reactive protein , tumor necrosis factor -α, tissue plasminogen activator inhibitor-1 ( PAI-1 )] were measured in 101 sedentary and 100 endurance-trained healthy Japanese women ( aged 18-23 years). (bvsalud.org)
- Serum adipokines including high molecular weight (HMW)-adiponectin, leptin, and soluble leptin receptor (sOB-R) were measured at the follow-up visit (2002-2003). (cdc.gov)
- Conclusions: Our findings suggest that molybdenum was associated with favorable profiles of HMW-adiponectin, leptin, and sOB-R. Exposures to cadmium, cesium, and lead were associated with adverse adipokine profiles. (cdc.gov)
- Adiponectin, leptin and resistin are adipocyte-secreted peptide hormones that may influence RCC development through their demonstrated effects on inflammation, insulin resistance and cell growth and proliferation. (arctichealth.org)
- We conducted a nested case-control study to evaluate whether prediagnostic serum adiponectin, leptin and resistin levels are associated with RCC risk. (arctichealth.org)
- Activation of adiponectin receptors (AdipoRs) by its natural ligand, adiponectin has been known to be involved in modulating critical metabolic processes such as glucose metabolism and fatty acid oxidation as demonstrated by a number of in vitro and in vivo studies over last two decades. (phoenixpeptide.com)
- Adiponectin is abundant in plasma and accounts for 0.01% of total plasma proteins in humans and 0.05% in rodents [9,12] .Two adiponectin receptors have been identified. (ommegaonline.org)
- Receptors for adiponectin, estradiol and antidiuretic hormone were more highly expressed in the summer months. (promegaconnections.com)
- A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome. (cdc.gov)
- Maternal plasma adiponectin showed inverse relations with glucose and homeostatic model assessment of insulin resistance (both P (biomedcentral.com)
- Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 aminoacid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells. (biovendor.com)
- The protein enhances insulin sensitivity by improving glucose and lipid metabolism, suggesting that adiponectin may have a role in preventing atherosclerosis, in addition to its beneficial impact on glucose and lipid homeostasis, and that improving levels of adiponectin could represent a novel therapeutic approach to the treatment of diabetes. (the-scientist.com)
- we investigated the relationship between the proinsulin-to-insulin ratio and adiponectin after adjusting for insulin sensitivity per metabolically active fat-free mass. (diabetesjournals.org)
- The partial correlation coefficient of adiponectin to the proinsulin-to-insulin ratio after controlling for insulin sensitivity was r = −0.24, two-tailed P = 0.12, and one-tailed P = 0.06. (diabetesjournals.org)
- Also, in an effort to determine if adiponectin is related to an index of glucose homeostasis, we evaluated the correlation of adiponectin with the glucose disposition index (product of insulin sensitivity × first-phase insulin secretion), which revealed that r = 0.35 and P = 0.013. (diabetesjournals.org)
- Adiponectin concentrations correlate negatively with glucose, insulin, triglyceride concentrations, liver fat content and body mass index and positively with high-density lipoprotein-cholesterol levels, hepatic insulin sensitivity and insulin-stimulated glucose disposal. (biovendor.com)
- Adiponectin has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation. (biovendor.com)
- The results support the theory that adiponectin might be part of a feedback mechanism improving insulin sensitivity and cardiovascular health in pre-eclamptic patients. (who.int)
- Subjects had their insulin sensitivity, body fat, CRP, and adiponectin levels measured, and their predicted maximal fitness calculated before and after 16 weeks of moderate, intense, or no exercise training. (elsevier.com)
- Modest improvements in fitness, body composition, and insulin sensitivity were observed, but these changes were not associated with decreased CRP or increased adiponectin levels, even when subjects were stratified by their change in fitness or obesity. (elsevier.com)
- Regression analysis demonstrated that the change in percentage of body fat was significantly related to changes in insulin sensitivity, whereas changes in VO 2 MAX, CRP, and adiponectin were not. (elsevier.com)
- Weight loss or caloric restriction results in increasing adiponectin levels, and this increase is related to enhanced insulin sensitivity. (cusabio.com)
- One of the most prevalent serum adipokines, adiponectin, is well-known for its function in regulating insulin sensitivity and preventing metabolic syndrome from developing. (iscience.in)
- Relationships of adiponectin to regional adiposity, insulin sensitivity, serum lipids, and inflammatory markers in sedentary and endurance-trained Japanese young women. (bvsalud.org)
- However, no significant correlation between adiponectin and insulin sensitivity was detected in both groups. (bvsalud.org)
- These findings suggest that adiponectin is primarily associated with regional adiposity and HDL-C regardless of insulin sensitivity and physical activity status in young, healthy women . (bvsalud.org)
- Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. (medecinesciences.org)
- Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study. (cdc.gov)
- Among various adipocyte-derived adipokines, adiponectin has attracted considerable attention due to its role in cardiovascular disorders. (docksci.com)
- CUSABIO's mouse adiponectin (ADP) ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative determination of adiponectin concentrations in serum, plasma, cell culture supernates, tissue homogenates, and cell lysates. (cusabio.com)
- This assay exclusively recognizes mouse adiponectin. (cusabio.com)
- Adiponectin is a circulating protein, the serum level of which is decreased in obesity and diabetes and in patients with coronary heart disease, and increased during weight loss. (the-scientist.com)
- Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular and metabolic risk, are highly heritable. (dtu.dk)
- The purpose of this study was to determine the effect of exercise training on the levels of C-reactive protein (CRP) and adiponectin, and to assess whether exercise-induced changes in insulin resistance could be explained in part by changes in these inflammation markers. (elsevier.com)
- Adiponectin is a protein that is related to how well you metabolize fat and even your risk of developing certain cancers. (susandopart.com)
- Circulating levels of adiponectin (AD), plasminogen activator inhibitor I (PAI-1), interleukin 18 (IL-18), C-reactive protein (CRP), fibrinogen, uric acid, lipids and insulin were measured. (warwick.ac.uk)
- Researchers theorize Raspberry Ketone causes the body to secret more Adiponectin, a protein hormone involved in metabolizing (breaking down) fatty acids and regulating glucose levels. (slimmersweekly.com)
- Around the same time, we and others described a protein that we initially termed Acrp30, which later became known as adiponectin ( 7 - 10 ). (diabetesjournals.org)
- Adiponectin is an adipocyte-specific protein abundantly present in the plasma. (ommegaonline.org)
- Finally, we discuss the potential involvement of endoplasmic reticulum stress and mitochondrial stress in diet-induced adiponectin downregulation and highlight the roles of Disulfide bond A oxidoreductase-like protein (DsbA-L) in the prevention of endoplasmic reticulum stress and promotion of adiponectin multimerization, stability, and function. (unm.edu)
- Adiponectin (APN), an adipocytokine, is secreted by the adipose tissue and has been debated both as a pro-inflammatory or anti-inflammatory protein depending on the disease condition and microenvironment. (mycologics.net)
- 2007). Exercise training is associated with improved levels of C-reactive protein and adiponectin in ZDF (type 2) diabetic rats . (up.pt)
- Novel modulator for endothelial adhesion molecules : adipocyte-derived plasma protein adiponectin. (medecinesciences.org)
- PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. (medecinesciences.org)
- Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis. (bvsalud.org)
Role of adiponectin2
- However, reports of the role of adiponectin in pre-eclampsia are conflicting. (who.int)
- However, the role of adiponectin in the development of cardiac diseases remains less clear than it does for metabolic disorders. (biomedcentral.com)
Expression of adiponectin2
- Moreover, serum levels of N-terminal pro-natriuretic peptide (NT-proBNP) and interleukin-6 (IL-6) as well as serum level and tissue expression of adiponectin were determined at the same time as echocardiography. (biomedcentral.com)
- Objective To investigate the effects of hypoxia induced by CoCl 2 on the expression of adiponectin (ADPN) in mouse 3T3-L1 adipocytes. (shsmu.edu.cn)
- Paradoxically, adipose tissue-expressed adiponectin levels are inversely related to the degree of adiposity. (biovendor.com)
- Of particular interest is that low adiponectin serum levels predict type 2 diabetes independent of other risk factors. (biovendor.com)
- Low serum adiponectin levels are found in patients with coronary artery disease. (biovendor.com)
- Moreover, high circulating levels of adiponectin are associated with decreased risk of myocardial infarction, independent of other factors. (biovendor.com)
- To gain insights into the biology that regulates adiponectin levels, we performed an exome array meta-analysis of 265,780 genetic variants in 67,739 individuals of European, Hispanic, African American, and East Asian ancestry. (dtu.dk)
- To identify potential genes and mechanisms through which the previously unreported association signals act to affect adiponectin levels, we assessed cross-trait associations, expression quantitative trait loci in subcutaneous adipose, and biological pathways of nearby genes. (dtu.dk)
- Taken together, these findings provide further insights into the processes that influence circulating adiponectin levels. (dtu.dk)
- This study in Egypt investigated the association between serum adiponectin levels and pre-eclampsia and between adiponectin levels and some clinical and hormonal parameters. (who.int)
- Serum adiponectin levels in pre-eclamptic women were significantly higher than in normal pregnant women and the increase was more marked in cases of severe pre-eclampsia. (who.int)
- There was a significant negative correlation between adiponectin levels and arterial blood pressure in all groups. (who.int)
- However, there was no correlation between serum adiponectin and proteinuria or estradiol and progesterone levels. (who.int)
- A single bout of t'ai chi (TC) exercise was previously found to be associated with a significant increase in post-exercise adiponectin levels in individuals with cardiovascular risk factors. (eurekamag.com)
- The objective of this study was to examine the long-term effects of 24-month habitual TC exercise on adiponectin levels, glucose homeostasis, lipid profile, and atherosclerotic burden in individuals with cardiovascular risk factors. (eurekamag.com)
- The results of the present study indicate that for individuals with at least one cardiovascular risk factor, engaging in habitual TC exercise could lead to favorable changes in levels of adiponectin. (eurekamag.com)
- Adiponectin exhibits cardioprotective properties in experimental studies, but elevated levels have been linked to increased mortality in older adults and patients with chronic heart failure (HF). (elsevier.com)
- High levels of adiponectin may mark or mediate age-related processes that lead to HF in older adults. (elsevier.com)
- Maybe it's your Adiponectin Levels? (susandopart.com)
- One study showed adiponectin levels rose 260% after 2-3 bouts of exercise and stayed elevated for a few weeks. (susandopart.com)
- Fourteen different studies have shown that fish oil moderately increases adiponectin levels. (susandopart.com)
- More research is needed but in the meantime the take home message is lifestyle modification can be helpful in treating adiponectin levels, which can help other hormone imbalances, such as insulin resistance leading to weight loss. (susandopart.com)
- HFD feeding induced cardiac insulin resistance in Ad-KO mice, which was reversed following replenishment of normal circulating adiponectin levels. (biomedcentral.com)
- In addition, myocardial total triglyceride was elevated by HFD and lipidomic analysis showed increased levels of ceramides and sphingosine-1-phosphate (S1P), with only the latter being corrected by adiponectin administration. (biomedcentral.com)
- Circulating adiponectin (Ad) levels correlate negatively with visceral obesity, diabetes and cardiovascular diseases [ 5 ]. (biomedcentral.com)
- In adults, levels of Adiponectin are inversely correlated with body fat percentage. (slimmersweekly.com)
- Thereafter, adiponectin levels increased prior to occurrence of systolic dysfunction. (biomedcentral.com)
- Initial evidence from clinical studies showed that exposure to angiotensin II receptor blockers increased circulating levels of adiponectin. (biomedcentral.com)
- In this study, we examined whether serum and tissue adiponectin levels are associated with onset of heart failure from hypertension through left ventricular hypertrophy in rats in comparison with other known biomarkers for heart function and inflammation. (biomedcentral.com)
- Obstructive sleep apnea (OSA) has been suggested to be associated with low levels of adiponectin. (docksci.com)
- The present meta-analysis was performed to determine whether CPAP therapy could increase adiponectin levels. (docksci.com)
- The meta-analysis showed that there was no change of adiponectin levels before and after CPAP treatment in OSA patients (SMD = 0.059, 95% confidence interval (CI) = −0.250 to 0.368, z = 0.37, p = 0.710). (docksci.com)
- It has been suggested that reduced serum adiponectin levels could partly explain increased cardiovascular disease in OSA patients. (docksci.com)
- Previous studies showed that OSA was associated with significant decrease in serum adiponectin levels[6-8]. (docksci.com)
- However, whether serum adiponectin levels may be ameliorated or not by CPAP is unclear. (docksci.com)
- The aim of the present meta-analysis was to quantitatively evaluate the impact of CPAP on adiponectin levels in OSA patients. (docksci.com)
- The quantitative sandwich ELISA technique of this kit is based on adiponectin antibody-adiponectin antigen interactions and an HRP colorimetric detection system to detect the levels of adiponectin in samples. (cusabio.com)
- Low plasma levels of adiponectin, also known as hypoadiponectinemia, are linked to the increased prevalence of obesity-associated diseases, including type 2 diabetes, coronary heart disease, and hypertension. (cusabio.com)
- The negative correlation of adiponectin levels and visceral adiposity is stronger than between adiponectin levels and subcutaneous adiposity [13,14] , and higher concentrations were found in females compared to men. (ommegaonline.org)
- Subsequent studies revealed that serum adiponectin levels correlated negatively with visceral fat area(VFA) determined by CT  . (ommegaonline.org)
- In obese individuals, circulating adiponectin levels correlated negatively with VFA, but not with BMI or subcutaneous fat area (SFA)  , suggesting that serum adiponectin concentrations are related to visceral adiposity. (ommegaonline.org)
- This study was planned to investigate the effect of coenzyme Q10 (CoQ10) supplementation on glycaemic control, oxidative stress (OS), and adiponectin levels in type 2 diabetic (T2DM) patients. (eaglebio.com)
- It is the first study on diabetic patients focused on evaluating the effect of CoQ10 on adiponectin levels. (eaglebio.com)
- In conclusion, after eight weeks of supplementation with CoQ10 , it may reduce OS in T2DM patients but it may not change glycaemic control and adiponectin levels. (eaglebio.com)
- Enhancing Adiponectin levels might reduce body fat levels. (rehobothstarfishing.com)
- This study aimed to determine the association of interleukin (IL)-10 and adiponectin (Ad) levels with the angiographic severity of coronary artery disease (CAD). (ijcva.com)
- By investigating paired subcutaneous (SAT) and visceral adipose tissue (VAT) as well as blood (cell) samples of GDM-affected ( n = 25) vs. matched control ( n = 30) mother-child dyads of the prospective " EaCH " cohort study, we addressed whether alterations of adiponectin plasma, mRNA, and DNA methylation levels are associated with GDM and offspring characteristics. (biomedcentral.com)
- Total serum adiponectin levels were measured by immunoassay. (who.int)
- Before understanding the different glucose tests like HbA1c, fasting blood glucose, insulin resistance score and adiponectin, let's look at some of the causes of abnormal blood sugar levels. (medchunk.com)
- In obese men, reduction in adiponectin levels may partly decipher the multitudinous pathways linking obesity-mediated metabolic disturbances, inflammation, and male infertility or subfertility. (iscience.in)
- This study aims to compare the differences in circulating adiponectin levels and their relationships to regional adiposity , insulin resistance , serum lipid , and inflammatory factors in young, healthy Japanese women with different physical activity statuses. (bvsalud.org)
- No significant difference was observed between the sedentary and trained women in terms of adiponectin levels. (bvsalud.org)
- Our results suggest that elevated levels of circulating adiponectin are associated with decreased subsequent risk of RCC. (arctichealth.org)
- CLA reduces the body's cancer-fighting levels of adiponectin. (ourdogsworld101.com)
- Serum adiponectin levels were measured using radioimmunoassay. (who.int)
- Adiponectin levels decreased with increasing severity of NAFLD. (who.int)
- Interpretation & conclusion: NAFLD is associated with lower serum adiponectin levels independent of conventional cardiovascular risk factors in Asian Indians known to have high prevalence of diabetes and coronary artery disease. (who.int)
- It does so by helping you to burn calories, improve lean mass levels and switching on important fat burning hormones such as adiponectin . (testofuel.com)
- Monounsaturated fat increases a hormone called adiponectin, which helps to regulate blood sugar levels that were disrupted by the previous night's alcohol consumption. (charlottesbook.com)
- Flavonoids contained in Kaempferia parviflora also increase secretion of adiponectin - a hormone that regulates glucose levels and fatty acid breakdown - in in vitro tests. (humanclinicals.org)
- Niacin (nicotinic acid) has recently been shown to increase serum adiponectin concentrations in men with the metabolic syndrome. (nih.gov)
- Initial in vivo studies in rats demonstrated that niacin (30 mg/kg po) acutely increases serum adiponectin concentrations, whereas it decreases NEFAs. (nih.gov)
- To further substantiate these in vitro findings, wild-type and GPR109A receptor knockout mice were administered a single dose of niacin or placebo, and serum was obtained for the determination of adiponectin and NEFA concentrations. (nih.gov)
- Serum adiponectin concentrations increased and serum NEFAs decreased in the wild-type mice within 10 min following niacin administration. (nih.gov)
- However, niacin administration had no effect on adiponectin and NEFA concentrations in the GPR109A receptor knockout mice. (nih.gov)
- The relations of total and HMW adiponectin with HF were nonlinear, with significant associations observed only for concentrations greater than the median (12.4 and 6.2 mg/L, respectively). (elsevier.com)
- After adjustment for potential confounders, the hazard ratios per SD increment in total adiponectin were 0.93 (95% confidence interval 0.72 to 1.21) for concentrations less than the median and 1.25 (95% confidence interval 1.14 to 1.38) higher than the median. (elsevier.com)
- In conclusion, total and HMW adiponectin showed comparable relations with incident HF in this older cohort, with a threshold effect of increasing risk occurring at their median concentrations. (elsevier.com)
- This product is manufactured by BioVision, an Abcam company and was previously called 4902 Adiponectin, murine recombinant. (abcam.com)
- 6-week-old male adiponectin knock out (Ad-KO) mice were fed chow or 60% HFD for 6 weeks then received saline or recombinant adiponectin (3μg/g body weight) for an additional 2 weeks. (biomedcentral.com)
- Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes. (cdc.gov)
- Adiponectin (ADP) is an adipocyte hormone involved in glucose and lipid metabolism. (elsevier.com)
- Adiponectin (Ad) is one such marker which is a 30-kDa peptide hormone exclusively secreted by adipose tissue. (ijcva.com)
- These potential signaling mediators include glucose, free fatty acids, autonomic nerves, fat-derived hormones (eg, adiponectin), and the gut hormone glucagonlike peptide-1 (GLP-1). (medscape.com)
- And a study from Korea found that they boosted secretion by fat cells of the hormone adiponectin, which regulates the processing of sugar and fats. (drweil.com)
- The fatderived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. (medecinesciences.org)
- 2003. Adiponectin: more than just another fat cell hormone? (csic.es)
- It is also an excellent SARM to prevent muscle loss due to the increased fat-burning qualities of ostarine by decreasing the production of the hormone adiponectin, best sarms dealers. (socalsendy.com)
- Adiponectin has been shown to have beneficial cardioprotective effects, including direct metabolic, insulin-sensitizing, and anti-apoptotic effects [ 5 ]. (biomedcentral.com)
- Through its receptor AdipoR1 and AdipoR2, adiponectin signaling is involved in numerous essential regulatory cellular signaling mechanisms including AMPK, p38/MAPK signaling, STAT3, and lipid metabolic pathways. (cusabio.com)
- Adiponectin critically contributes to metabolic homeostasis, especially by insulin-sensitizing action. (biomedcentral.com)
- Lifestyle plus exercise intervention improves metabolic syndrome markers without change in adiponectin in obese girls. (bvsalud.org)
- Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations. (cdc.gov)
- No difference for adiponectin distribution among visceral adipose tissues was found. (biomedcentral.com)
- Under normal conditions the adiponectin gene (apM1) is expressed exclusively in adipose tissue. (ommegaonline.org)
- Further in vitro studies demonstrated an increase in adiponectin secretion and a decrease in lipolysis in primary adipocytes following treatment with niacin or beta-hydroxybutyrate (an endogenous ligand of the GPR109A receptor), but these effects were blocked when adipocytes were pretreated with pertussis toxin. (nih.gov)
- Niacin had no effect on adiponectin secretion or lipolysis in 3T3-L1 adipocytes, which have limited cell surface expression of the GPR109A receptor. (nih.gov)
Secretion of adiponectin1
- However, little is known about the mechanism(s) by which niacin regulates the intracellular trafficking and secretion of adiponectin. (nih.gov)
- These findings provide the strongest evidence to date, suggesting that the association between obesity and RCC is mediated at least in part through the effects of low adiponectin. (arctichealth.org)
- Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. (biovendor.com)
- Mouse globular domain Adiponectin expressed in E. coli. (universalbiologicals.com)
- The concentration of total adiponectin converted to monomeric form, ranged from 5 to 30 μg/mL. (ommegaonline.org)
- This research is still in the very early stages but a few studies exist which reveal how one can increase adiponectin. (susandopart.com)
- This Adiponectin ELISA Kit is a quick, simple, and sensitive assay for the quantitative determination of human adiponectin in human serum and plasma. (eaglebio.com)
- Adiponectin migrated to a high molecular weight position in western blotting under non-denatured condition or in western blotting of fractionated plasma by gel filtration chromatography  , suggesting the formation of high-ordered structure and/or binding to other plasma proteins. (ommegaonline.org)
- Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. (medecinesciences.org)
- AdipoR1 is a receptor for globular adiponectin and is abundantly expressed in skeletal muscle, whereas AdipoR2,a receptor for full-length adiponectin, is mainly expressed in the liver. (ommegaonline.org)
- 1 ) in this issue of Diabetes Care regarding adiponectin in youth. (diabetesjournals.org)
- Adiponectin is a fat tissue-derived adipokine with beneficial effects against diabetes, cardiovascular diseases, and cancer. (phoenixpeptide.com)
- Discovery of Adiponectin and its Future Prospect (2014) J Diabetes Obes 1(1): 8- 13. (ommegaonline.org)
- Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes. (cdc.gov)
- The correlation of LFM and a favorable lipid profile against CVD and adiponectin is likely involved in this association . (bvsalud.org)
Receptor 1 gene2
- Similar to adiponectin, ADP-1 increased the expression of the adiponectin receptor 1 gene. (phoenixpeptide.com)
- Association between adiponectin receptor 1 gene polymorphism and insulin resistance in Chinese patients with polycystic ovary syndrome. (cdc.gov)
- Because of limitations in production of biologically active adiponectin, adiponectin-mimetic AdipoRs' agonists have been suggested as alternative ways to expand the opportunity to develop anti-diabetic agents. (phoenixpeptide.com)
- A collagen domain-derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms. (phoenixpeptide.com)
- Consistent with the HF findings, higher adiponectin tended to be associated with left ventricular systolic dysfunction and left atrial enlargement. (elsevier.com)
- Triglyceride in the sedentary women was closely and negatively associated with adiponectin , as well as PAI-1 in the trained women . (bvsalud.org)
- Multiple logistic regression analysis revealed adiponectin to be negatively associated with NAFLD [Odds Ratio (OR): 0.865, 95% Confidence Interval (CI): 0.792- 0.944, P=0.001]. (who.int)
- Adiponectin gene polymorphisms and acute respiratory distress syndrome susceptibility and mortality. (cdc.gov)
- Measurements on adiponectin, glucose homeostasis, lipid profile, and atherosclerotic burden were made at three time points-baseline, 12 months, and 24 months. (eurekamag.com)
- The aim of this study was to investigate the associations of total and high-molecular weight (HMW) adiponectin with incident HF (n = 780) and, in a subset, echocardiographic parameters in a community-based cohort of adults aged ≥65 years. (elsevier.com)
- Adiponectin, which exists in serum in three major complexes including trimer, hexamer, and the high molecular weight (HMW) form, has strong insulin sensitizing, anti-inflammatory and anti-diabetic functions. (unm.edu)
- Adiponectin is reported to relate with cardiovascular diseases, we sought to examine whether adiponectin is associated with disease progression of heart failure from hypertension in rats in comparison with other known biomarkers and echocardiographic parameters. (biomedcentral.com)
- Furthermore, LFM was associated with a favorable lipid profile against cardiovascular diseases (CVDs) in the whole study cohort, but this association became insignificant when adiponectin was taken into account. (bvsalud.org)
- To our knowledge this is the first report on identification of a short peptidefrom adiponectin with positive effects on glucose or fatty acid metabolism. (phoenixpeptide.com)
- Background & objective: Association between adiponectin and non-alcoholic fatty liver disease (NAFLD) has been reported in west. (who.int)
- Adiponectin has profound insulin-sensitizing, anti-inflammatory and anti-atherogenic effects. (who.int)
- Since its discovery, numerous experimental and clinical studies have demonstrated that adiponectin has anti-atherogenic, antidiabetic and anti-inflammatory properties. (ommegaonline.org)
- Conclusions Reduced adiponectin seems to be a pathogenic co-factor in GDM, even independent of BMI, affecting materno-fetal metabolism. (biomedcentral.com)
- Collectively, adiponectin appears to be not only a specific factor for regulating materno-fetal metabolism but also an important candidate in GDM pathophysiology. (biomedcentral.com)
- Adiponectin diminishes platelet aggregation and sCD40L release. (core.ac.uk)
- We never implied that a direct effect of adiponectin on insulin secretory function exists. (diabetesjournals.org)