Adipokines
Resistin
Adiponectin
A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.
Nicotinamide Phosphoribosyltransferase
An enzyme that catalyzes the formation of nicotinamide mononucleotide (NMN) from nicotinamide and 5-phosphoribosyl-1-pyrophosphate, the rate-limiting step in the biosynthesis of the NAD coenzyme. It is also known as a growth factor for early B-LYMPHOCYTES, or an ADIPOKINE with insulin-mimetic effects (visfatin).
Leptin
Adipose Tissue
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Obesity
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Adipocytes
Retinol-Binding Proteins, Plasma
Insulin Resistance
Adiposity
Metabolic Syndrome X
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
Adipose Tissue, White
Receptors, Adiponectin
Cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin.
Inflammation
3T3-L1 Cells
Interleukin-6
Body Mass Index
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
Intra-Abdominal Fat
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Inflammation Mediators
Overnutrition
C-Reactive Protein
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Receptors, Leptin
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Hormones, Ectopic
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Omentum
Intercellular Signaling Peptides and Proteins
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Ghrelin
A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.
Peptide Hormones
Angiopoietins
Lipocalins
A diverse family of extracellular proteins that bind to small hydrophobic molecules. They were originally characterized as transport proteins, however they may have additional roles such as taking part in the formation of macromolecular complexes with other proteins and binding to CELL SURFACE RECEPTORS.
Plasminogen Activator Inhibitor 1
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Body Weight
Liver Transplantation
Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages. (1/819)
Atherosclerosis is initiated by the infiltration of monocytes into the subendothelial space of the vessel wall and subsequent lipid accumulation of the activated macrophages. The molecular mechanisms involved in the anomalous behavior of macrophages in atherogenesis have only partially been disclosed. Chitotriosidase and human cartilage gp-39 (HC gp-39) are members of the chitinase family of proteins and are expressed in lipid-laden macrophages accumulated in various organs during Gaucher disease. In addition, as shown in this study, chitotriosidase and HC gp-39 can be induced with distinct kinetics in cultured macrophages. We investigated the expression of these chitinase-like genes in the human atherosclerotic vessel wall by in situ hybridizations on atherosclerotic specimens derived from femoral artery (4 specimens), aorta (4 specimens), iliac artery (3 specimens), carotid artery (4 specimens), and coronary artery (1 specimen), as well as 5 specimens derived from apparently normal vascular tissue. We show for the first time that chitotriosidase and HC gp-39 expression was strongly upregulated in distinct subsets of macrophages in the atherosclerotic plaque. The expression patterns of chitotriosidase and HC gp-39 were compared and shown to be different from the patterns observed for the extracellular matrix protein osteopontin and the macrophage marker tartrate-resistant acid phosphatase. Our data emphasize the remarkable phenotypic variation among macrophages present in the atherosclerotic lesion. Furthermore, chitotriosidase enzyme activity was shown to be elevated up to 55-fold in extracts of atherosclerotic tissue. Although a function for chitotriosidase and HC gp-39 has not been identified, we hypothesize a role in cell migration and tissue remodeling during atherogenesis. (+info)Serum YKL-40 and colorectal cancer. (2/819)
YKL-40 is a mammalian member of the chitinase protein family. Although the function of YKL-40 is unknown, the pattern of its expression suggests a function in remodelling or degradation of extracellular matrix. High serum YKL-40 has been found in patients with recurrent breast cancer and has been related to short survival. In the present study we analysed YKL-40 in preoperative sera from patients with colorectal cancer and evaluated its relation to survival. Serum YKL-40 was determined by RIA in 603 patients. Survival after operation was registered, and median follow-up time was 61 months. Three hundred and forty patients died. Sixteen per cent of the patients with Dukes' A, 26% with Dukes' B, 19% with Dukes' C and 39% with Dukes' D had high serum YKL-40 levels (adjusted for age). Analysis of serum YKL-40 as a continuous variable showed an association between increased serum YKL-40 and short survival (P < 0.0001). Patients with high preoperative serum YKL-40 concentration had significantly shorter survival than patients with normal YKL-40 (HR = 1.7; 95% CI: 1.3-2.1, P < 0.0001). Multivariate Cox analysis including serum YKL-40, serum CEA, Dukes' stage, age and gender showed that high YKL-40 was an independent prognostic variable for short survival (HR = 1.4; 95% CI: 1.1-1.8, P = 0.007). These results suggest that YKL-40 may play an important role in tumour invasion. (+info)T cell responses to a human cartilage autoantigen in the context of rheumatoid arthritis-associated and nonassociated HLA-DR4 alleles. (3/819)
OBJECTIVE: To analyze the CD4+ T cell responses to the human cartilage antigen glycoprotein-39 (HCgp-39) in the context of rheumatoid arthritis (RA)-associated (DRalphabeta1*0401) and nonassociated (DRalphabeta1*0402) HLA class II molecules. METHODS: Large numbers of HCgp-39-specific T cell hybridomas were generated following immunization of HLA-DR4/human CD4 transgenic, murine major histocompatibility complex class II deficient mice with native HCgp-39. Fine epitope mapping of DRalphabeta1*0401-and DRalphabeta1*0402-restricted T cell hybridomas was performed using overlapping synthetic peptides. Antigen-specific cytokine production by lymph node T cells was evaluated after immunization with native antigen. Proliferative T cell responses of healthy human subjects were compared with the T cell responses of patients with active RA using HCgp-39 epitopes defined in HLA-DR4 transgenic mice. RESULTS: CD4+ T cells from DRalphabeta1*0401 and DRalphabeta1*0402 transgenic mice identified completely different immunodominant peptide epitopes of HCgp-39, and this was not explained by known DR4-binding motifs or direct peptide-binding studies. DRalphabeta1*0401-restricted, antigen-specific T cells produced significantly more interferon-gamma and tumor necrosis factor a in response to HCgp-39 than did T cells from DRalphabeta1*0402 transgenic mice. Finally, HCgp-39 peptides defined in DRalphabeta1*0401 transgenic mice stimulated T cells from HLA-DR4 positive human subjects and RA patients, but not T cells from HLA-DR4 negative individuals. CONCLUSION: T cell epitopes of HCgp-39 that were defined in HLA-DR4 transgenic mice stimulated T cells from human subjects carrying RA-associated HLA-DR4 alleles. HLA-DR4 molecules may influence the disease process in RA both by presentation of selected peptide epitopes and by promoting the production of proinflammatory cytokines in synovial joints. (+info)Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity. (4/819)
OBJECTIVE: YKL-40, also called human cartilage glycoprotein-39, is secreted by chondrocytes, synovial cells, macrophages and neutrophils. Studies have shown that YKL-40 is an autoantigen in rheumatoid arthritis (RA). We evaluated whether serum YKL-40 was related to disease activity in patients with RA. METHODS: Serum YKL-40 was determined by radioimmunoassay in 156 patients with RA during a 1 yr longitudinal study. RESULTS: Serum YKL-40 was increased in 54% of the patients with clinically active disease. Patients with clinically active disease initially who became inactive after 12 months had a significant decrease in serum YKL-40 (-30%, P < 0.002) and patients who changed from inactive to active disease had an increase in serum YKL-40. Patients who remained active had unchanged serum YKL-40 during the study. Serum YKL-40 decreased rapidly (-24% after 7 days, P < 0.01) during prednisolone therapy, and more slowly in patients treated with methotrexate only (-15% after 60 days, P < 0.01). Patients with early RA (disease duration < 3 yr, n = 50) and a persistently elevated serum YKL-40 were at risk of radiological disease progression as determined by Larsen score. CONCLUSION: Serum YKL-40 varies according to disease activity in RA, but provides in some respect information different from conventional markers. Our previous studies are consistent with a local release of YKL-40 in the arthritic joint followed by a secondary increase in serum YKL-40. YKL-40 may prove to be a new tool for the study of disease activity and pathophysiology of RA. (+info)YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization. (5/819)
The serum concentration of YKL-40, a matrix protein of specific granules in neutrophils, was determined by RIA in 90 patients hospitalized with pneumonia of suspected bacterial origin. Of these, 64 were followed prospectively during antibiotic treatment with blood samples taken on day 0 (on admission and the start of treatment) and on days 1, 3, 5, 7, 10, and 21. Serum YKL-40 at admission was increased in patients with Streptococcus pneumoniae pneumonia (median, 893 microgram/L; 95% confidence interval [CI], 704-1560), compared with healthy subjects (median, 102 microgram/L; 95% CI, 64-247 microgram/L; P<.001) and in patients with pneumonia of unknown etiology (median, 448 microgram/L; 95% CI, 334-700; P<.05). Peak YKL-40 serum values were observed on day 1 and thereafter declined steeply to almost normal by day 3. During the first 10 days, there was a close relation between serum YKL-40 and markers of specific granules of neutrophils (serum lactoferrin and neutrophil gelatinase-associated lipocalin), which suggests that serum YKL-40 reflects exocytosis of specific granules of neutrophils in persons with acute bacterial pneumonia. (+info)YKL-40 in giant cells and macrophages from patients with giant cell arteritis. (6/819)
OBJECTIVE: YKL-40, a mammalian member of the family 18 glycosyl hydrolases, is secreted by activated macrophages at a late stage of differentiation. Macrophages are present in inflammation of the arterial wall and are thought to participate in the pathogenesis of giant cell arteritis (GCA). The aim of this study was to evaluate whether macrophages and giant cells of patients with GCA produce YKL-40, and whether serum YKL-40 concentrations are elevated in these patients. METHODS: Serum YKL-40 was determined by radioimmunoassay in 19 patients with GCA and 8 patients with polymyalgia rheumatica (PMR) who were followed up prospectively during 1 year of treatment with prednisolone. Immunohistochemical staining for YKL-40 was performed in temporal artery biopsy samples that were obtained before treatment. RESULTS: In the arteritic vessels of patients with GCA, positive staining for the YKL-40 antigen was found in CD68+ giant cells and mononuclear cells located in the media. Macrophages located in the adventitia and intima were negative for YKL-40. At the time of diagnosis, patients with GCA had an increased median serum level of YKL-40 (256 microg/liter; P<0.01) compared with healthy age-matched controls (median 118 microg/liter), and the serum level of YKL-40 decreased to normal levels during prednisolone treatment (-38% after 1 month; P<0.001). Most patients with PMR had normal serum YKL-40 levels (median 158 microg/liter) and had no changes in the serum YKL-40 levels during prednisolone treatment. The observed changes in serum YKL-40 did not always parallel the changes in serum C-reactive protein levels and erythrocyte sedimentation rate during the 1-year study period. CONCLUSION: YKL-40 is found in CD68+ giant cells and mononuclear cells in the media of arteritic vessels of patients with GCA, and the concentration of serum YKL-40 may reflect the local activity of these cells in the inflamed artery. (+info)Induction of tolerance with intranasal administration of human cartilage gp-39 in DBA/1 mice: amelioration of clinical, histologic, and radiologic signs of type II collagen-induced arthritis. (7/819)
OBJECTIVE: Human cartilage glycoprotein 39 (HC gp-39) was recently identified as a candidate autoantigen in the pathogenesis of rheumatoid arthritis. In the present studies, we investigated the capacity of HC gp-39 to interfere in clinical disease induced by an unrelated autoantigen, type II collagen (CII), by the induction of cross-tolerance. METHODS: DBA-1j/Bom mice were immunized with bovine CII/complete Freund's adjuvant and were given intraperitoneal booster injections of CII on day 21. Tolerance was induced via the intranasal pathway with either the disease-inducing antigen (CII), a control antigen (ovalbumin), or HC gp-39 either before priming with CII or near the day of the booster injection. Arthritis was monitored visually, and joint pathology was examined histologically and radiologically. In addition, CII antibody levels in serum were analyzed by enzyme-linked immunosorbent assay. RESULTS: In contrast to treatment before priming, intranasal application of HC gp-39 after immunization markedly suppressed disease activity and prevented joint destruction, whereas application of ovalbumin or CII was ineffective. Interference of HC gp-39 with the immune response to CII was demonstrated by decreased anti-CII antibody levels. The combined data indicate that intranasal treatment with HC gp-39 may trigger modulatory or regulatory mechanisms that interfere with the expression of disease in murine collagen-induced arthritis. CONCLUSION: HC gp-39 is the first cross-tolerance-inducing protein in arthritis that down-modulates a spectrum of disease features when given in a semitherapeutic protocol. (+info)Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization. (8/819)
OBJECTIVE: To examine the expression pattern of human cartilage glycoprotein 39 (HC gp-39) mRNA in human cartilage and bone. DESIGN: In-situ hybridization analysis was used to examine the expression pattern of human cartilage glycoprotein 39 (HC gp-39) mRNA in adult human osteoarthritic articular cartilage from various stages of disease, as well as in human osteophytic tissue and in human fetal bone. RESULTS: In cartilage from patients with mild osteoarthritic cartilage degeneration, HC gp-39 was expressed at moderate to high levels only in chondrocytes of the superficial zone. In advanced OA cartilage, cloning chondrocytes of the superficial zone expressed high levels of HC gp-39 and chondrocytes of the mid- and deep zones were also positive. HC gp-39 was undetectable in the chondrocytes of normal articular cartilage. In osteophytic tissue, the expression of HC gp-39 mRNA was intense in flattened, end-stage osteoblasts and in primary osteocytes in both endochondral and intramembranous bone formation. Proliferating osteoblasts expressed low to moderate levels. Notably, mature osteocytes were negative for HC gp-39 expression. Chondrocytes in the secondary ossification center of developing fetal cartilage demonstrated high expression while growth plate and mineralized cartilage chondrocytes had lower expression. Osteoblasts at sites of endochondral and intramembranous bone formation were positive for expression of HC gp-39. CONCLUSIONS: The stage-specific expression of HC gp-39 in fetal development and adult remodelling bone and cartilage provides evidence for a specific functional or structural role for HC gp-39 in bone and cartilage tissue. HC gp-39 is expressed in diseased human osteoarthritic cartilage and osteophyte, but not in non-diseased tissue, and its distribution within the tissue changes as disease progresses. OA is characterized not only by cartilage degeneration, but by increased subchondral bone formation and osteophytosis. The results from this study indicate that the increased HC gp-39 expression in OA serum and synovial fluid may reflect not only cartilage degeneration but increased osteogenesis. (+info)Serum adipokine and inflammatory markers before and after liver transplantation in recipients with major cardiovascular events<...
Adipokines in Plasma and Breast Tissues: Associations with Breast Cancer Risk Factors | Cancer Epidemiology, Biomarkers &...
Adipokines as key players in β cell function and failure | Clinical Science | Portland Press
Adipokines as key players in β cell function and failure | Clinical Science | Portland Press
Adipokines: A gear shift in puberty
Repositorio da Producao Cientifica e Intelectual da Unicamp: Adipokines: Novel Players In Resistant Hypertension
The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue
Invited review - Physiological roles of adipokines, hepatokines, and myokines in ruminants<...
Signalling role of adipose tissue: adipokines and inflammation in obesity
03 | June | 2017 | Evolution of NADPH Oxidase Inhibitors
Fehér Ágnes - ODT Személyi adatlap
sj-pdf-1-lup-10.1177 0961203320935185 - Supplemental material for Insulin resistance and serum levels of adipokines in patients...
Changes in protein levels of adipokines in 3T3-L1 cells | Open-i
IntechOpen Open Access Publisher - Open Science Open Minds | IntechOpen
Adipocytokines and pituitary function
Science of Weight Loss: The fat Resistance Diet | ENCOGNITIVE.COM
Forskolin Inhibits Lipopolysaccharide-Induced Modulation of MCP-1 and GPR120 in 3T3-L1 Adipocytes Through an Inhibition of NFκB...
DiVA - Search result
Adipokines in Autism - Inflammation | asdresearchinitiative
Adipolin/FAM132A Antibodies: Novus Biologicals
WAT rhythms
Adipose Tissue And Adipokines In Health And Disease (Nutrition And Health) (Hardcover)
Political News | Irish & International Politics | The Irish Times
Adipose tissue quantity and composition contribute to adipokine concentrations in the subclavian vein and the inferior...
The adipokines in the pathogenesis and treatment of nonalcoholic fatty liver disease - hippokratia.gr
Supplementary Figure 1. mrna expression of chitinase and chitinase-like protein in splenic immune cells. Each splenic immune...
北京大学医学部机构知识库([email protected]): Human Secreted Stabilin-1-Interacting Chitinase-like Protein Aggravates the Inflammation Associated...
Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies | BMC Cancer | Full Text
5-Lipoxygenase Activating Protein Signals Adipose Tissue Inflammation and Lipid Dysfunction in Experimental Obesity | The...
op.7d.10] the Effect of Renal Denervation on Adipokines in Patients with Resistant Hypertension. - Semantic Scholar
Perivascular adipose tissue as a regulator of vascular disease pathogenesis: identifying novel therapeutic targets. - Radcliffe...
Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle...
Plus it
OP68 How is overweight/obesity across the life course associated with levels of adipokines, inflammatory and endothelial...
Changes in adipokine levels before intravenous immunogl | Open-i
Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins - Research - The Capital Region...
DOAB: Directory of Open Access Books
Duration of Lactation and Maternal Adipokines at 3 Years Postpartum
Effects of short-term dry immersion on bone remodeling markers, insulin and adipokines - статья | ИСТИНА - Интеллектуальная...
Valproic Acid and CEBPα-Mediated Regulation of Adipokine Gene Expression in Hypothalamic Neurons and 3T3-L1 Adipocytes -...
Inflammation Matters » psoriasis
Parent-Offspring Transmission of Adipocytokine Levels and Their Associations with Metabolic Traits
Plus it
Adipobiology of diabetes mellitus<...
Adipokines: therapeutic targets for metabolic syndrome. - PubMed - NCBI
Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice - Dimensions
Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study - Central Connecticut State...
The Carb-Sane Asylum: Adipocyte Size & Adipokine Secretion
Perivascular adipose tissue and coronary atherosclerosis - Oxford Cardiovascular Science
IntechOpen Open Access Publisher - Open Science Open Minds | IntechOpen
Ijfas vol2
Observational Study of Early Metabolic and Vascular Changes in Obesity - Full Text View - ClinicalTrials.gov
Loss of Krüppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12...
TamPub - Selaus tekijän mukaan Leppänen, Tiina
Paneristi Public Forum: *** SIHH 2012 | RADIOMIR CALIFORNIA 3 DAYS - 47 MM - PAM448 SPECIAL EDITION ***
CTRP7抗体|Abcam中国|Anti-CTRP7抗体(ab115449)
Adipokine
The first adipokine to be discovered was leptin in 1994. Since that time, hundreds of adipokines have been discovered. Members ... Adipokines at the US National Library of Medicine Medical Subject Headings (MeSH) (Articles with short description, Short ... The adipokines, or adipocytokines (Greek adipo-, fat; cytos-, cell; and -kinos, movement) are cytokines (cell signaling ... Conde J, Scotece M, Gómez R, López V, Gómez-Reino JJ, Lago F, Gualillo O (2011). "Adipokines: BioFactors from white adipose ...
SERPIN A12
... is a protease inhibitor with an approximate weight of 47 kDa and is a member of the adipokine family of cytokines ... "Adipokines". US National Library of Medicine Medical Subject Headings (MeSH). January 1, 2008. Retrieved November 1, 2020. ... Kyrou I, Mattu HS, Chatha K, Randeva HS (2017). "Fat Hormones, Adipokines". Endocrinology of the Heart in Health and Disease. ...
CCL7
Ouchi N, Parker JL, Lugus JJ, Walsh K (February 2011). "Adipokines in inflammation and metabolic disease". Nature Reviews. ...
Leptin
... including the cell signalling proteins known as adipokines. Certain adipokines can be considered as hormones, as they regulate ... March 2014). "Adipokines as drug targets in joint and bone disease". Drug Discovery Today. 19 (3): 241-258. doi:10.1016/j. ... Conde J, Scotece M, Gómez R, López V, Gómez-Reino JJ, Lago F, Gualillo O (2011). "Adipokines: biofactors from white adipose ... Leptin was the first fat cell-derived hormone (adipokine) to be discovered. Subsequent studies in 1995 confirmed that the db ...
Christos Socrates Mantzoros
Ko, Byung-Joon; Park, Kyung Hee; Mantzoros, Christos S (2014). "Diet patterns, adipokines, and metabolism: Where are we and ... Polyzos, Stergios A; Kountouras, Jannis; Mantzoros, Christos S (2016). "Adipokines in nonalcoholic fatty liver disease". ... Boutari, Chrysoula; Perakakis, Nikolaos; Mantzoros, Christos S (2018). "Association of Adipokines with Development and ... myokines and adipokines (i.e. leptin and adiponectin) in human physiology and pathophysiology. Leptin has subsequently been ...
Obesity-associated morbidity
The result is reduction of the testis' production of testosterone and a further increase in adipokine levels. This then feeds ... Peterlin BL, Sacco S, Bernecker C, Scher AI (April 2016). "Adipokines and Migraine: A Systematic Review". Headache. 56 (4): 622 ... In males, obesity and metabolic syndrome both increase estrogen and adipokine production. This reduces gonadotropin-releasing ...
Hepatokine
Adipokines Myokines Meex, Ruth C. R.; Watt, Matthew J. (September 2017). "Hepatokines: linking nonalcoholic fatty liver disease ...
Obesity and fertility
Adipocytes (fat cells) secrete proteins and signaling molecules known as adipokines. Certain adipokines have been implicated in ... Pro-inflammatory adipokines secreted by adipocytes have been demonstrated to stimulate fatty acid accumulation. Fatty acids are ... Leptin is a satiety adipokine released from adipocytes. Normally, leptin interacts with leptin receptors (LEPRs) in the brain ... Mitchell M, Armstrong DT, Robker RL, Norman RJ (November 2005). "Adipokines: implications for female fertility and obesity". ...
Hepatic portal system
Dhawan D, Sharma S (2020). "Abdominal Obesity, Adipokines and Non-communicable Diseases". The Journal of Steroid Biochemistry ...
Adipose tissue
Ohta H, Itoh N (2014). "Roles of FGFs as Adipokines in Adipose Tissue Development, Remodeling, and Metabolism". Frontiers in ... Perivascular adipose tissue releases adipokines such as adiponectin that affect the contractile function of the vessels that ... Mancuso P (May 2016). "The role of adipokines in chronic inflammation". ImmunoTargets and Therapy. 5 (2016): 47-56. doi:10.2147 ... Adipose Tissue and Adipokines in Health and Disease. Nutrition and Health. Humana Press. pp. 221-236. doi:10.1007/978-1-59745- ...
C-reactive protein
Lau DC, Dhillon B, Yan H, Szmitko PE, Verma S (May 2005). "Adipokines: molecular links between obesity and atheroslcerosis". ...
FAM132A
Adipolin is an adipokine. GRCh38: Ensembl release 89: ENSG00000184163 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... a novel adipokine in human and murine ATDC-5 chondrocyte cell line". Ann. Rheum. Dis. 72 (1): 140-2. doi:10.1136/annrheumdis- ... "Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism". J. Biol. Chem. 286 (40): 34552-8. ...
Pathophysiology of obesity
The adipokines are mediators produced by adipose tissue; their action is thought to modify many obesity-related diseases. ...
Drifty gene hypothesis
Adipose Tissue and Adipokines in Health and Disease. New York: Humana Press: 193-208. Speakman, John R (July 11, 2007). " ...
Resistin
This adipokine is associated with markers of inflammation in seminal plasma and the concentrations of seminal resistin ... Elfassy Y, Bastard JP, McAvoy C, Fellahi S, Dupont J, Levy R (2018). "Adipokines in Semen: Physiopathology and Effects on ... Malyszko J, Malyszko JS, Pawlak K, Mysliwiec M (December 2006). "Resistin, a new adipokine, is related to inflammation and ... an adipokine-mediated process?". Diabetes. 51 (10): 2951-8. doi:10.2337/diabetes.51.10.2951. PMID 12351432. Levy JR, Davenport ...
George Chaldakov
Chaldakov GN, Stankulov IS, Hristova MG, Ghenev PI (2003). "Adipobiology of disease: adipokines and adipokine-targeted ... Conceptualize the protein secretory products of adipose tissue cells as adipokines, also focusing on perivascular adipose ... adipokines, cytokines). In 1991, Chaldakov became founder and chief editor of Biomedical Reviews, An International Journal of ...
Nicotinamide phosphoribosyltransferase
Bełtowski J (June 2006). "Apelin and visfatin: unique "beneficial" adipokines upregulated in obesity?". Medical Science Monitor ...
Haptoglobin
"Entrez Gene: HP". Trayhurn P, Wood IS (September 2004). "Adipokines: inflammation and the pleiotropic role of white adipose ... "Bovine haptoglobin as an adipokine: Serum concentrations and tissue expression in dairy cows receiving a conjugated linoleic ...
N-Acylethanolamine
Trayhurn, Paul; Bing, Chen; Wood, I. Stuart (2006-07-01). "Adipose Tissue and Adipokines-Energy Regulation from the Human ...
List of human endocrine organs and actions
Signalling molecules released by adipose tissue are referred to as adipokines. Vander A (2008). Vander's Human Physiology: the ...
Obesity
Theodore Mazzone; Giamila Fantuzzi (2006). Adipose Tissue And Adipokines in Health And Disease (Nutrition and Health). Totowa, ...
Equine metabolic syndrome
It is possible adipokines and cytokines made in adipose tissue down-regulate insulin pathways. It is also possible that IR ... The cells of adipose (fat) tissue synthesizes hormones known as adipokines. In humans, dysfunction of adipose tissue, even in ... leading to the production of more adipokines and perpetuation of the cycle, and a constant low-level, pro-inflammatory state. ...
EDIL3
... a novel adipokine in the regulation of angiogenesis". J. Clin. Endocrinol. Metab. 95 (5): 2476-85. doi:10.1210/jc.2010-0042. ...
TRHDE
... a novel adipokine in the regulation of angiogenesis". The Journal of Clinical Endocrinology and Metabolism. 95 (5): 2476-85. ...
B-cell activating factor
Kim YH, Choi BH, Cheon HG, Do MS (March 2009). "B cell activation factor (BAFF) is a novel adipokine that links obesity and ... "B cell-activating factor controls the production of adipokines and induces insulin resistance". Obesity. 19 (10): 1915-22. doi: ...
Chemerin
Roh SG, Song SH, Choi KC, Katoh K, Wittamer V, Parmentier M, Sasaki S (Sep 2007). "Chemerin--a new adipokine that modulates ... Because of its role in adipocyte differentiation and glucose uptake, chemerin is classified as an adipokine. Chemerin has been ... a novel adipokine that regulates adipogenesis and adipocyte metabolism". J. Biol. Chem. 282 (38): 28175-88. doi:10.1074/jbc. ... "Chemerin is a novel adipokine associated with obesity and metabolic syndrome". Endocrinology. 148 (10): 4687-94. doi:10.1210/en ...
CMKLR1
As an adipokine receptor it has a role in adipogenesis and adipocyte maturation. It seems also to have a role in peripheral ... Chemokine receptor-like 1 is a G protein-coupled receptor for the chemoattractant adipokine chemerin and the omega-3 fatty acid ... Darios ES, Winner BM, Charvat T, Krasinksi A, Punna S, Watts SW (August 2016). "The adipokine chemerin amplifies electrical ... "Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice". Journal of Bone and Mineral Research. 32 (5 ...
Apelin
... a newly identified adipokine up-regulated by insulin and obesity". Endocrinology. 146 (4): 1764-71. doi:10.1210/en.2004-1427. ...
Undurti Narasimha Das
"Effects of bariatric surgery on adipokine-induced inflammation and insulin resistance". Frontiers in Endocrinology. 4: 69. doi: ...
Adiponectin
January 2014). "Serum adipokine levels in rheumatoid arthritis patients and their contributions to the resistance to treatment ... Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein hormone and adipokine, which is involved in ... Hara K, Yamauchi T, Kadowaki T (April 2005). "Adiponectin: an adipokine linking adipocytes and type 2 diabetes in humans". ...
Prediagnostic circulating adipokine concentrations and risk of renal cell carcinoma in male smokers. • Arctic Health
Chemerin--a new adipokine that modulates adipogenesis via its own receptor
Fat Hormones, Adipokines<...
... and hormones into the systemic circulation that are collectively described as adipokines. Adipokines exert pleiotropic effects ... and hormones into the systemic circulation that are collectively described as adipokines. Adipokines exert pleiotropic effects ... and hormones into the systemic circulation that are collectively described as adipokines. Adipokines exert pleiotropic effects ... and hormones into the systemic circulation that are collectively described as adipokines. Adipokines exert pleiotropic effects ...
British Library EThOS: Investigating the impact of c-Cbl deficiency in adipose tissue : its role in insulin sensitivity and...
The adipokine profile was altered in WAT of female Cbl -/- mice: leptin and RBP4 were increased, whereas adiponectin was ... However, the role of c-Cbl in adipokine expression is currently unknown. c-Cbl knockout (Cbl -/- ) mice were previously found ... Investigating the impact of c-Cbl deficiency in adipose tissue : its role in insulin sensitivity and adipokine production ... specifically in glucose and lipid metabolism and adipokine production. c-Cbl knockout mice exhibited no changes in overall food ...
In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children<...
In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. In: ... In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. / ... These data suggest that in the absence of weight loss, exercise training alone does not improve the adipokine profile or levels ... In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. ...
RePub, Erasmus University Repository:
First trimester secreted Frizzled-Related Protein 4 and other adipokine serum...
Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic individuals: a randomized controlled trial | Nutrition ...
Adipokines have been demonstrated to be vital targets of metabolic diseases. The hypothesis that adipokines mediate the ... Our study shows that CoQ10 ameliorates glucolipid profile and adipokines dysfunction in dyslipidemic patients in 24 weeks ... Adipokines have been demonstrated to be vital targets of metabolic diseases. The hypothesis that adipokines mediate the ... Mediating effects of adipokines. To further investigate the possible mechanism that adipokines mediated the relationship ...
Serum adipokine and inflammatory markers before and after liver transplantation in recipients with major cardiovascular events<...
Watt, K. D., Fan, C., Therneau, T., Heimbach, J. K., Seaberg, E. C., & Charlton, M. R. (2014). Serum adipokine and inflammatory ... Serum adipokine and inflammatory markers before and after liver transplantation in recipients with major cardiovascular events. ... In conclusion, pre- and post-LT changes in serum adipokine and inflammatory markers may be signals of an increased risk of CV ... Serum adipokine and inflammatory markers before and after liver transplantation in recipients with major cardiovascular events ...
Vitamin D insufficiency is associated with inflammation and deregulation of adipokines in patients with metabolic syndrome |...
Therefore, we assessed whether serum vitamin D status is associated with serum levels of adipokines and inflammatory markers in ... Besides, inflammation and deregulation of adipokines secretion have been recognized as pivotal factors that contribute to the ... findings indicated that vitamin D insufficiency in MetS patients is associated with increased inflammation and serum adipokine ... Table 2 Serum concentrations of adipokines and inflammatory markers in the participants by the vitamin D statusa. Full size ...
Adipokines and the intervertebral disc: does a biochemical link exist between obesity and back pain? - Nuffield Department of...
adipokines | aliquotthesciencespot
Adipokines as possible new predictors of cardiovascular diseases: a case control study.
IMSEAR at SEARO: Role of Adipokines in Development of Metabolic Syndrome
Role of Adipokines in Development of Metabolic Syndrome. Annals of the National Academy of Medical Sciences (India). 2018 Oct; ... Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Adipokines gene polymorphisms were studied by ... Visceral adipose tissue releases a variety of adipokines which together determine a comprehensive cardiometabolic risk profile ... Conclusively changes in fat distribution modulate the secretion profile of adipokines, therefore elevated circulating leptin, ...
Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across...
Adipokines Adiponectin Article Bayes Theorem Cross-Sectional Studies Female Humans Leptin Middle Aged Midlife Women Parabens ... Urinary Metals and Adipokines in Midlife Women: The Study of Womens Health Across the Nation (SWAN) Cite ... Adipokines, cytokines secreted by adipose tissue, may contribute to obesity-related metabolic disease. The role of ... Serum adipokines included adiponectin, high molecular weight (HMW)-adiponectin, leptin, soluble leptin receptor (sOB-R). Linear ...
Adipose Tissue | Diabetes | American Diabetes Association
Additional adipokines and the secretory pathway of adipocytes.. Adiponectin is not the only adipokine that attracted our ... An adipokine that has been the focus of a large number of studies over the last couple of years is the protein adiponectin. ... Using adipokines as one of the major communication tools, adipocytes affect a large number of other tissues, such as the liver ... They transcriptionally induce adipokines, such as adiponectin. They also regulate part of the machinery required for the ...
Adipokines and coronary vasomotor dysfunction<...
Particular emphasis is placed on the action of adipokines in the coronary circulation - especially effects of adipokines on ... Particular emphasis is placed on the action of adipokines in the coronary circulation - especially effects of adipokines on ... Particular emphasis is placed on the action of adipokines in the coronary circulation - especially effects of adipokines on ... Particular emphasis is placed on the action of adipokines in the coronary circulation - especially effects of adipokines on ...
Hypoadiponectinemia: A Link between Visceral Obesity and Metabolic Syndrome
These bioactive substances are classified as "adipokines or adipocytokines" and are subdivided into adipokines adipose tissue ... H. Zhang, J. Cui, and C. Zhang, "Emerging role of adipokines as mediators in atherosclerosis," World Journal of Cardiology, vol ... 2. The Adipokines. Adipose tissue participates in the regulation of a variety of homeostatic processes as an endocrine organ ... Adipokines and adipocytokines have a role both in the regulation of the glucose and lipid metabolism, in the control of ...
Solution structure of CXCL5 - A novel chemokine and adipokine implicated in inflammation and obesity<...
Solution structure of CXCL5 - A novel chemokine and adipokine implicated in inflammation and obesity. PloS one. 2014 Apr 2;9(4 ... Sepuru, K. M., Poluri, K. M., & Rajarathnam, K. (2014). Solution structure of CXCL5 - A novel chemokine and adipokine ... Solution structure of CXCL5 - A novel chemokine and adipokine implicated in inflammation and obesity. In: PloS one. 2014 ; Vol ... Sepuru, KM, Poluri, KM & Rajarathnam, K 2014, Solution structure of CXCL5 - A novel chemokine and adipokine implicated in ...
LEGENDplex Human Adipokine Panel Detection Antibodies
Human Adipokine Panel Detection Antibodies product is intended for use with the Mix and Match Human Adipokine Panel of products ... Human Adipokine Panel Detection Antibodies - The LEGENDplex™ ... The LEGENDplex™ Human Adipokine Panel Detection Antibodies product is intended for use with the Mix and Match Human Adipokine ... 740210 (LEGENDplex™ Human Adipokine Panel Standard). 740374 (LEGENDplex™ Buffer Set C). 740197 (LEGENDplex™ Human Adiponectin ...
Osteoarthritis Workup: Approach Considerations, Plain Radiography, MRI, CT, and Ultrasonography
Register - Enzo Life Sciences
Asthma control, adiposity, and adipokines among inner-city adolescents<...
keywords = "adipokines, adiponectin, asthma, leptin, Obesity",. author = "Meyer Kattan and Rajesh Kumar and Bloomberg, {Gordon ... Asthma control, adiposity, and adipokines among inner-city adolescents. In: The Journal of Allergy and Clinical Immunology. ... Asthma control, adiposity, and adipokines among inner-city adolescents. The Journal of Allergy and Clinical Immunology. 2010 ... Asthma control, adiposity, and adipokines among inner-city adolescents. Meyer Kattan, Rajesh Kumar, Gordon R. Bloomberg, Herman ...
The Adipokine-Cardiovascular-Lifestyle Network: Translation to Clinical Practice
Adipokines are peptides, secreted by adipocytes and other cell types with targets in other tissues, participating in a complex ... This review describes recent information about adipokine effects on the CV system. Rather than simply providing a listing of ... Various relationships and emergent processes in the adipokine-CV system network are discussed, with the most significant ... As more translatable information about the larger adipokine-CV-lifestyle network is acquired from laboratory and clinical ...
Osteoarthritis Treatment & Management: Approach Considerations, Pharmacologic Treatment, Lifestyle Modification, Physical...
Adipokines and osteoarthritis: Novel molecules involved in the pathogenesis and progression of disease
... Conde Aranda, Javier; ... In this paper, we review the role of adipokines and highlight the cellular and molecular mechanisms at play in osteoarthritis ... We also emphasize how defining the role of adipokines has broadned our understanding of the diversity of factors involved in ... called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. ...
Science Clips - Volume 13, Issue 21, June 22, 2021
Adipokines including leptin, soluble leptin receptor (sOB-R), free leptin index (FLI, the ratio of leptin to sOB-R), total and ... However, the effects of PFAS on adipokines are not well understood. OBJECTIVE: We determined if serum PFAS concentrations were ... Understanding associations between PFAS and adipokines may help elucidate whether PFAS can influence obesity and metabolic ... Associations of perfluoroalkyl and polyfluoroalkyl substances (PFAS) and PFAS mixtures with adipokines in midlife womenexternal ...
Leptin in the interplay of inflammation, metabolism and immune system disorders | Nature Reviews Rheumatology
... the most relevant factors secreted by adipose tissue and the forerunner of a class of molecules collectively called adipokines ... Dis. 70, 551-559 (2011). This article described for the first time the expression of a novel network of adipokines locally ... Basic aspects of adipokines in bone metabolism. Clin. Rev. Bone Miner. Metab. 13, 11-19 (2015). ... Systemic versus local adipokine expression differs in a combined obesity and osteoarthritis mouse model *Marie-Lisa Hülser ...
NIOSHTIC-2 Search Results - Full View
... were fit to identify metals associated with adipokines and to compute estimated percent changes in adipokines for one standard ... Serum adipokines including high molecular weight (HMW)-adiponectin, leptin, and soluble leptin receptor (sOB-R) were measured ... Urinary metals and adipokines in midlife women: the Study of Womens Health Across the Nation (SWAN). ... Background: Information on the associations between metal exposures and adipokines in human populations is limited and results ...
Search Results | Clinical Science | Portland Press
as an endocrine organ, secreting soluble factors termed adipocytokines or adipokines. These adipokines play crucial roles in ... change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune ... inflammatory adipokines in PE and healthy pregnancy. Subcutaneous and visceral adipose tissue biopsies were collected from ... with resistin, an adipokine that was shown to increase the permeability of endothelial cells in vitro , shedding light on the ...
AdiponectinAdiposeObesityOxidative stressAdipocytesConcentrationsInflammationResistinCytokinesBiomarkersChemerinAdipocyte-derivedMarkersObeseCoronaryAnti-inflammatorySerum levelsAdiposityHormones releasedDysfunctionCardiovascular diseasesMetabolismMetSOsteoarthritisLevelsProcessesRoleInflammatory stateEffectsUrinaryPregnancy
Adiponectin13
- The adipokine profile was altered in WAT of female Cbl -/- mice: leptin and RBP4 were increased, whereas adiponectin was reduced. (bl.uk)
- Some adipokines such as adiponectin can modulate transcription factor such as peroxisome proliferator- activated receptors (PPARs) that regulate gene expression involved in lipid metabolism in multiple tissues [ 9 ]. (biomedcentral.com)
- Adipokines' gene polymorphisms were studied by polymerase chain reaction and mRNA expression of leptin, adiponectin, resistin, and interleukin-6 (IL-6). (who.int)
- Conclusively changes in fat distribution modulate the secretion profile of adipokines, therefore elevated circulating leptin, IL-6, TNF-α, ASP, resistin, and low adiponectin may serve as surrogate markers for metabolic syndrome and related morbidities in women with central obesity. (who.int)
- Serum adipokines including high molecular weight (HMW)-adiponectin, leptin, and soluble leptin receptor (sOB-R) were measured at the follow-up visit (2002-2003). (cdc.gov)
- Conclusions: Our findings suggest that molybdenum was associated with favorable profiles of HMW-adiponectin, leptin, and sOB-R. Exposures to cadmium, cesium, and lead were associated with adverse adipokine profiles. (cdc.gov)
- The effect of leptin and adiponectin, which are two adipokines with opposing effects, has been explored in this study. (openrepository.com)
- In order to explore the role of adipokines in cardiovascular diseases, EAHY human endothelial cells were cultured and treated with various concentrations of adiponectin and leptin both individually and in combinations and cells collected and mRNA extracted in order to carry out a reverse transcription PCR for the expression of angiogenic (TIMP2, TIMP3 and MMP2) genes and atherosclerotic (LPA and LPL) genes. (openrepository.com)
- The adipokines, leptin and adiponectin, have a prominent role in the pathogenesis of coronary artery disease (CAD). (ac.ir)
- Considering the presence of significant association between leptin and MPO, as well as adiponectin and MPO in patients with CAD, it may be inferred that the contribution of the adipokines in the pathogenesis of CAD may be, in part, through affecting the MPO concentration. (ac.ir)
- Adipokines, including leptin and adiponectin, may be involved in the pathogenesis of CKD. (medpagetoday.com)
- There is an increasing recognition that adipose tissue is an endocrine organ secreting a number of biologically active adipokines such as leptin, adiponectin, and tumor necrosis factor-α. (docksci.com)
- Among various adipocyte-derived adipokines, adiponectin has attracted considerable attention due to its role in cardiovascular disorders. (docksci.com)
Adipose12
- Adipose tissue functions as a dynamic endocrine organ secreting multiple proteins, factors, and hormones into the systemic circulation that are collectively described as adipokines. (aston.ac.uk)
- Expanding adipose tissue in obesity undergoes a change in the adipokine secretion profile characterized by an increase of proinflammatory adipokines and suppression of anti-inflammatory adipokines increasing proinflammatory pathways within adipose tissue depots and creating an adverse circulating adipokine profile, resulting in a chronic, low-grade, systemic inflammatory state. (aston.ac.uk)
- This chapter presents a brief overview of the nature of adipose tissue in obesity and focuses on selected adipokines that have direct and indirect effects on the heart and cardiovascular system. (aston.ac.uk)
- In this study, the role of c-Cbl signalling was examined in white adipose tissue (WAT) of a Cbl -/- mouse model, specifically in glucose and lipid metabolism and adipokine production. (bl.uk)
- Visceral adipose tissue releases a variety of adipokines which together determine a comprehensive cardiometabolic risk profile. (who.int)
- As the master regulator of systemic lipid storage and through secretion of a number of these adipokines, adipose tissue has an influence on many processes, including energy metabolism, inflammation, and pathophysiological changes such as cancer and infectious disease ( 4 ). (diabetesjournals.org)
- Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fat cells produce a plethora of factors, called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. (sergas.gal)
- Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a class of molecules collectively called adipokines. (nature.com)
- Obesity affects about 520 million people world-wide and more recently studies have shown that fat cells produce proteins called adipokines which have various influences on the human metabolism and has helped to change the perspectives of researchers on the concept of the adipose tissue being just a store of energy. (openrepository.com)
- [10-12] In addition to deposition and expenditure of energy, adipose tissues are probably the largest endocrine organ in the body, which produce a myriad of endocrine hormones and adipokines. (lww.com)
- Lastly, I investigated the effects of maternal exposure to obesity-inducing high fat diet or adipose-tissue derived adipokine leptin during pregnancy on offspring's risk of endometrial carcinogenesis in Pten+/- and wild type mice. (georgetown.edu)
- Adipose tissue is not considered anymore as a passive depot for storing excess energy in the form of triglycerides but as an active organ secreting several hormones or adipokines. (bvsalud.org)
Obesity8
- Compelling evidence directly links the adverse proinflammatory adipokine profile in obesity with a spectrum of detrimental cardio-metabolic effects including hepatic, skeletal muscle, and myocardial insulin resistance, hypertension, atherosclerosis, hypercoagulability, thrombosis, and endothelial and cardiac dysfunction. (aston.ac.uk)
- Therefore, Adipokines have also became a pivotal target for treatment of obesity, dyslipidemia and hyperglycemia. (biomedcentral.com)
- Adipokines and the intervertebral disc: does a biochemical link exist between obesity and back pain? (ox.ac.uk)
- Adipokines are peptides, secreted by adipocytes and other cell types with targets in other tissues, participating in a complex network of humoral factors involved in obesity, insulin resistance, and cardiovascular (CV) disease. (uab.edu)
- The Role of adipokines in obesity related beta-cell failure of diabetes mellitus and endothelial cell dysfunction of cardiovascular diseases. (openrepository.com)
- As a result of this, adipokines have been reported to represent a connection between obesity and cardiovascular diseases (CVD) and diabetes mellitus. (openrepository.com)
- A series of tests pointed to a specific enzyme called adipokine nicotinamide phosphoribosyltransferase, (NAMPT), which is known to be involved in some of the pathological metabolic problems caused by obesity. (eurekalert.org)
- Polymorphisms in Adipokines in Mexican Children with Obesity. (cdc.gov)
Oxidative stress5
- The aim of the present study was to examine the effect of exercise training on adipokines, inflammatory markers, and oxidative stress in overweight children. (umn.edu)
- 05) but did not change any of the measured adipokines or the marker of systemic oxidative stress, 8-isoprostane. (umn.edu)
- These data suggest that in the absence of weight loss, exercise training alone does not improve the adipokine profile or levels of oxidative stress in overweight children. (umn.edu)
- inflammatory and oxidative stress markers, and adipokines will be evaluated in a subsample. (clinicaltrials.gov)
- Hess DA and Hegele RA Linking diabetes with oxidative stress, adipokines, and impaired endothelial precursor cell function. (stemcellsportal.com)
Adipocytes4
- In several animal models, it has now been clearly demonstrated that the induction of a controlled but sustained mitochondrial uncoupling can limit the lipid accumulation in adipocytes, limiting the deleterious effects associated with adipocyte hypertrophy such as organelle dysfunction and alterations in the expression of genes encoding adipokines. (unamur.be)
- Indeed, it is now commonly admitted that adipocytes also behave as key endocrine cells by synthesizing and secreting more than 600 adipokines. (unamur.be)
- The aims of the present study was 1) to characterize the effect(s) of a mild mitochondrial uncoupling in 3T3-L1 adipocytes induced by a prolonged incubation (3 days) with low concentration (0.5 μM) of a chemical mitochondrial uncoupler such as FCCP (carbonyl cyanide-4- (trifluoromethoxy)phenylhydrazone) on lipolysis and 2) to analyze the expression of several genes encoding adipokines in adipocytes exposed to the uncoupler. (unamur.be)
- In the second part of this work, we identified several adipokines that are differentially expressed at the protein and/or at the mRNA level(s) in adipocytes exposed to FCCP. (unamur.be)
Concentrations3
- Prediagnostic circulating adipokine concentrations and risk of renal cell carcinoma in male smokers. (arctichealth.org)
- Linear regression models with adaptive elastic-net (AENET) were fit to identify metals associated with adipokines and to compute estimated percent changes in adipokines for one standard deviation increase in log-transformed urinary metal concentrations. (cdc.gov)
- The concentrations and the bases of the effects of the adipokines in beta cell failure of diabetes mellitus and endothelial cell dysfunction of cardiovascular diseases are still not fully understood. (openrepository.com)
Inflammation3
- Besides, inflammation and deregulation of adipokines secretion have been recognized as pivotal factors that contribute to the pathogenesis of these conditions. (biomedcentral.com)
- Our findings indicated that vitamin D insufficiency in MetS patients is associated with increased inflammation and serum adipokine abnormalities which may be associated with developing metabolic complications in these patients. (biomedcentral.com)
- Objective Chemerin, a recently identified adipokine, has been linked to adiposity, insulin resistance, metabolic syndrome risk factors and inflammation. (elsevier.com)
Resistin1
- Additional proteins have joined this exclusive club of adipocyte-specific secretory proteins since then, including adipokines such as resistin ( 11 , 12 ) and acylation-stimulating protein ( 13 ), as well as the recently described visfatin ( 14 , 15 ) and retinol-binding protein-4 ( 16 ). (diabetesjournals.org)
Cytokines2
- The aim of this study was to assess the concentration of selected pro-inflammatory adipokines and cytokines in the unstimulated saliva of obese people with fatty liver disease in various stages (with or without slight fibrosis ) and to analyze them for possible use as early markers of NAFLD diagnosis . (bvsalud.org)
- Fat tissue produces proteins called cytokines, chemokines, and adipokines. (medicalnewstoday.com)
Biomarkers2
- Circulating inflammatory biomarkers, adipokines and breast cancer risk-a case-control study nested within the EPIC cohort. (who.int)
- The regulation and imbalance expression of the novel biomarkers, including inflammatory adipokine, macrophage infiltration, angiogenesis, and lymphangiogenesis in EAT and PAT, may be related to the pathogenesis of CAD. (bvsalud.org)
Chemerin1
- Thus, the adipokine chemerin likely regulates adipocyte function by autocrine/paracrine mechanisms. (nih.gov)
Adipocyte-derived1
- This leads to a dysregulation of triglyceride and free fatty acid levels, as well as a dysregulation of specific adipocyte-derived secretory proteins, a group of proteins that we refer to as adipokines. (diabetesjournals.org)
Markers4
- In conclusion, pre- and post-LT changes in serum adipokine and inflammatory markers may be signals of an increased risk of CV events after LT, but further study is needed. (elsevier.com)
- Therefore, we assessed whether serum vitamin D status is associated with serum levels of adipokines and inflammatory markers in these patients. (biomedcentral.com)
- Considering limited data available on this subject, especially in developing countries, we examined vitamin D status in relation to adipokines and inflammatory markers in patients with metabolic syndrome in a case-control study. (biomedcentral.com)
- This review aims to determine the impact of exercise on cytokine and adipokine profile levels as inflammatory markers in MS patients across various exercise paradigms. (bvsalud.org)
Obese5
- Pro-Inflammatory Adipokine and Cytokine Profiles in the Saliva of Obese Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)-A Pilot Study. (bvsalud.org)
- Effect of Testosterone Treatment on Adipokines and Gut Hormones in Obese Men on a Hypocaloric Diet. (austin.org.au)
- Adipokines and genetic factors in overweight or obese but metabolically healthy Polish women. (nel.edu)
- Bik W, Ostrowski J, Baranowska-Bik A, Wolinska-Witort E, Bialkowska M, Martynska L, Baranowska B. Adipokines and genetic factors in overweight or obese but metabolically healthy Polish women. (nel.edu)
- Recently cartonectin was reported as a novel adipokine, with lower levels in diet-induced obese mice, glucose-lowering effects, and antiinflammatory and cardioprotective properties. (webpediatrica.com)
Coronary2
- Particular emphasis is placed on the action of adipokines in the coronary circulation - especially effects of adipokines on endothelial function, as endothelial damage is likely a critical event initiating atherosclerotic coronary artery disease. (unthsc.edu)
- In this study, we explored the relationship between inflammatory adipokine levels and coronary artery disease (CAD). (bvsalud.org)
Anti-inflammatory2
- Serum pro- and anti-inflammatory adipokine levels were higher and lower, respectively, in the CAD group than those in the control group (P (bvsalud.org)
- Pro-inflammatory adipokine mRNA expression was increased, while anti-inflammatory adipokine mRNA expression decreased, in CAD relative to NCAD in EAT and PAT rather than SAT. In EAT, adipocyte area and macrophage-specific staining were lower, while lymphatic vessel marker expression was higher in CAD. (bvsalud.org)
Serum levels1
- The serum levels of inflammatory adipokines may correlate to CAD, which requires large sample size studies to get further validation before clinic practice. (bvsalud.org)
Adiposity1
- There was no relationship between adiposity or adipokines and total IgE levels, blood eosinophil counts, and exhaled nitric oxide levels. (elsevier.com)
Hormones released2
- The hormones released by WAT are called adipokines. (frontiersin.org)
- Adipokines are hormones released specifically from your fat cells. (bodybuilding.com)
Dysfunction2
- Our study shows that CoQ10 ameliorates glucolipid profile and adipokines dysfunction in dyslipidemic patients in 24 weeks' intervention. (biomedcentral.com)
- This review presents basic historical background information on the major adipokines, introduces findings from clinical studies associating adipokines with cardiovascular disease, and summarizes results from recent basic science research studies of mechanisms of adipokine-induced cardiovascular dysfunction. (unthsc.edu)
Cardiovascular diseases2
- Adipokines as possible new predictors of cardiovascular diseases: a case control study. (unifi.it)
- Adipokines as possible new predictors of cardiovascular diseases: a case control study / L. Pala;M. Monami;S. Ciani;I. Dicembrini;A. Pasqua;A. Pezzatini;P. Francesconi;B. Cresci;E. Mannucci;C. M. Rotella. (unifi.it)
Metabolism3
- Adipokines exert pleiotropic effects on target tissues/organs thereby regulating energy homeostasis, metabolism, and insulin sensitivity, as well as immune and cardiovascular functions. (aston.ac.uk)
- The hypothesis that adipokines mediate the association of CoQ10 on glucolipid metabolism needs to be further studied in human. (biomedcentral.com)
- These adipokines play crucial roles in whole-body metabolism with different mechanisms of action largely dependent on the tissue or cell type they are acting on. (portlandpress.com)
MetS1
- The link between this vitamin and adipokines and inflammatory factors, especially in MetS patients, received less attention. (biomedcentral.com)
Osteoarthritis2
- In this paper, we review the role of adipokines and highlight the cellular and molecular mechanisms at play in osteoarthritis elicited by adipokines. (sergas.gal)
- We also emphasize how defining the role of adipokines has broadned our understanding of the diversity of factors involved in the genesis and progression of osteoarthritis in the hope of modifying it to prevent and treat diseases. (sergas.gal)
Levels3
- In the nontransplant setting, aberrant serum adipokine levels are associated with cardiovascular (CV) disease. (elsevier.com)
- The effects of liver transplantation (LT) on serum adipokine levels and their association with post-LT CV disease have not been studied. (elsevier.com)
- In CAD, the pro-inflammatory adipokine levels via ELISA in EAT and PAT were elevated. (bvsalud.org)
Processes1
- Various relationships and emergent processes in the adipokine-CV system network are discussed, with the most significant interactors being responses to hypoxia, regulation of cell migration, effects on blood coagulation, and platelet activation. (uab.edu)
Role2
- However, the role of c-Cbl in adipokine expression is currently unknown. (bl.uk)
- As more translatable information about the larger adipokine-CV-lifestyle network is acquired from laboratory and clinical research, the strategic and precise role of lifestyle intervention can be fashioned to improve CV outcomes. (uab.edu)
Inflammatory state1
- multiple cell types whose collective secretome, termed as adipokines , is highly interdependent on metabolic homeostasis and inflammatory state. (portlandpress.com)
Effects2
Urinary1
- Urinary metals and adipokines in midlife women: the Study of Women's Health Across the Nation (SWAN). (cdc.gov)
Pregnancy1
- inflammatory adipokines in PE and healthy pregnancy. (portlandpress.com)