AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
AdipokinesResistinAdiponectinNicotinamide PhosphoribosyltransferaseLeptinAdipose TissueObesityAdipocytesRetinol-Binding Proteins, PlasmaInsulin ResistanceAdiposityMetabolic Syndrome XSubcutaneous FatAdipose Tissue, WhiteReceptors, AdipokineReceptors, AdiponectinInflammation3T3-L1 CellsInterleukin-6Body Mass IndexIntra-Abdominal FatBiological MarkersInflammation MediatorsOvernutritionC-Reactive ProteinTumor Necrosis Factor-alphaReceptors, LeptinCytokinesHormones, EctopicInsulinOmentumIntercellular Signaling Peptides and ProteinsGhrelinPeptide HormonesAngiopoietinsLipocalinsBlood GlucosePlasminogen Activator Inhibitor 1Case-Control StudiesBody WeightLiver TransplantationCardiovascular Diseases
Adipokines
Polypeptides produced by the ADIPOCYTES. They include LEPTIN; ADIPONECTIN; RESISTIN; and many cytokines of the immune system, such as TUMOR NECROSIS FACTOR-ALPHA; INTERLEUKIN-6; and COMPLEMENT FACTOR D (also known as ADIPSIN). They have potent autocrine, paracrine, and endocrine functions.
Resistin
A 12-kDa cysteine-rich polypeptide hormone secreted by FAT CELLS in the ADIPOSE TISSUE. It is the founding member of the resistin-like molecule (RELM) hormone family. Resistin suppresses the ability of INSULIN to stimulate cellular GLUCOSE uptake.
Adiponectin
A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.
Nicotinamide Phosphoribosyltransferase
An enzyme that catalyzes the formation of nicotinamide mononucleotide (NMN) from nicotinamide and 5-phosphoribosyl-1-pyrophosphate, the rate-limiting step in the biosynthesis of the NAD coenzyme. It is also known as a growth factor for early B-LYMPHOCYTES, or an ADIPOKINE with insulin-mimetic effects (visfatin).
Leptin
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
Adipose Tissue
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Obesity
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Adipocytes
Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.
Retinol-Binding Proteins, Plasma
Retinol binding proteins that circulate in the PLASMA. They are members of the lipocalin family of proteins and play a role in the transport of RETINOL from the LIVER to the peripheral tissues. The proteins are usually found in association with TRANSTHYRETIN.
Insulin Resistance
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
Adiposity
The amount of fat or lipid deposit at a site or an organ in the body, an indicator of body fat status.
Metabolic Syndrome X
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
Subcutaneous Fat
Fatty tissue under the SKIN through out the body.
Adipose Tissue, White
Fatty tissue composed of WHITE ADIPOCYTES and generally found directly under the skin (SUBCUTANEOUS FAT) and around the internal organs (ABDOMINAL FAT). It has less vascularization and less coloration than the BROWN FAT. White fat provides heat insulation, mechanical cushion, and source of energy.
Receptors, Adipokine
Cell surface receptors for ADIPOKINES, cytokines secreted by the ADIPOCYTES.
Receptors, Adiponectin
Cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin.
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
3T3-L1 Cells
A continuous cell line that is a substrain of SWISS 3T3 CELLS developed though clonal isolation. The mouse fibroblast cells undergo an adipose-like conversion as they move to a confluent and contact-inhibited state.
Interleukin-6
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
Body Mass Index
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
Intra-Abdominal Fat
Fatty tissue inside the ABDOMINAL CAVITY, including visceral fat and retroperitoneal fat. It is the most metabolically active fat in the body and easily accessible for LIPOLYSIS. Increased visceral fat is associated with metabolic complications of OBESITY.
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Inflammation Mediators
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
Overnutrition
An imbalanced NUTRITIONAL STATUS resulting from excessive intake of nutrients. Generally, overnutrition generates an energy imbalance between food consumption and energy expenditure leading to disorders such as OBESITY.
C-Reactive Protein
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Receptors, Leptin
Cell surface receptors for obesity factor (LEPTIN), a hormone secreted by the WHITE ADIPOCYTES. Upon leptin-receptor interaction, the signal is mediated through the JAK2/STAT3 pathway to regulate food intake, energy balance and fat storage.
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Hormones, Ectopic
Hormones released from neoplasms or from other cells that are not the usual sources of hormones.
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Omentum
A double-layered fold of peritoneum that attaches the STOMACH to other organs in the ABDOMINAL CAVITY.
Intercellular Signaling Peptides and Proteins
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Ghrelin
A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.
Peptide Hormones
Hormones synthesized from amino acids. They are distinguished from INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS in that their actions are systemic.
Angiopoietins
A family of structurally-related angiogenic proteins of approximately 70 kDa in size. They have high specificity for members of the TIE RECEPTOR FAMILY.
Lipocalins
A diverse family of extracellular proteins that bind to small hydrophobic molecules. They were originally characterized as transport proteins, however they may have additional roles such as taking part in the formation of macromolecular complexes with other proteins and binding to CELL SURFACE RECEPTORS.
Blood Glucose
Glucose in blood.
Plasminogen Activator Inhibitor 1
A member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Liver Transplantation
The transference of a part of or an entire liver from one human or animal to another.
Cardiovascular Diseases
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages. (1/819)

Atherosclerosis is initiated by the infiltration of monocytes into the subendothelial space of the vessel wall and subsequent lipid accumulation of the activated macrophages. The molecular mechanisms involved in the anomalous behavior of macrophages in atherogenesis have only partially been disclosed. Chitotriosidase and human cartilage gp-39 (HC gp-39) are members of the chitinase family of proteins and are expressed in lipid-laden macrophages accumulated in various organs during Gaucher disease. In addition, as shown in this study, chitotriosidase and HC gp-39 can be induced with distinct kinetics in cultured macrophages. We investigated the expression of these chitinase-like genes in the human atherosclerotic vessel wall by in situ hybridizations on atherosclerotic specimens derived from femoral artery (4 specimens), aorta (4 specimens), iliac artery (3 specimens), carotid artery (4 specimens), and coronary artery (1 specimen), as well as 5 specimens derived from apparently normal vascular tissue. We show for the first time that chitotriosidase and HC gp-39 expression was strongly upregulated in distinct subsets of macrophages in the atherosclerotic plaque. The expression patterns of chitotriosidase and HC gp-39 were compared and shown to be different from the patterns observed for the extracellular matrix protein osteopontin and the macrophage marker tartrate-resistant acid phosphatase. Our data emphasize the remarkable phenotypic variation among macrophages present in the atherosclerotic lesion. Furthermore, chitotriosidase enzyme activity was shown to be elevated up to 55-fold in extracts of atherosclerotic tissue. Although a function for chitotriosidase and HC gp-39 has not been identified, we hypothesize a role in cell migration and tissue remodeling during atherogenesis.  (+info)

Serum YKL-40 and colorectal cancer. (2/819)

YKL-40 is a mammalian member of the chitinase protein family. Although the function of YKL-40 is unknown, the pattern of its expression suggests a function in remodelling or degradation of extracellular matrix. High serum YKL-40 has been found in patients with recurrent breast cancer and has been related to short survival. In the present study we analysed YKL-40 in preoperative sera from patients with colorectal cancer and evaluated its relation to survival. Serum YKL-40 was determined by RIA in 603 patients. Survival after operation was registered, and median follow-up time was 61 months. Three hundred and forty patients died. Sixteen per cent of the patients with Dukes' A, 26% with Dukes' B, 19% with Dukes' C and 39% with Dukes' D had high serum YKL-40 levels (adjusted for age). Analysis of serum YKL-40 as a continuous variable showed an association between increased serum YKL-40 and short survival (P < 0.0001). Patients with high preoperative serum YKL-40 concentration had significantly shorter survival than patients with normal YKL-40 (HR = 1.7; 95% CI: 1.3-2.1, P < 0.0001). Multivariate Cox analysis including serum YKL-40, serum CEA, Dukes' stage, age and gender showed that high YKL-40 was an independent prognostic variable for short survival (HR = 1.4; 95% CI: 1.1-1.8, P = 0.007). These results suggest that YKL-40 may play an important role in tumour invasion.  (+info)

T cell responses to a human cartilage autoantigen in the context of rheumatoid arthritis-associated and nonassociated HLA-DR4 alleles. (3/819)

OBJECTIVE: To analyze the CD4+ T cell responses to the human cartilage antigen glycoprotein-39 (HCgp-39) in the context of rheumatoid arthritis (RA)-associated (DRalphabeta1*0401) and nonassociated (DRalphabeta1*0402) HLA class II molecules. METHODS: Large numbers of HCgp-39-specific T cell hybridomas were generated following immunization of HLA-DR4/human CD4 transgenic, murine major histocompatibility complex class II deficient mice with native HCgp-39. Fine epitope mapping of DRalphabeta1*0401-and DRalphabeta1*0402-restricted T cell hybridomas was performed using overlapping synthetic peptides. Antigen-specific cytokine production by lymph node T cells was evaluated after immunization with native antigen. Proliferative T cell responses of healthy human subjects were compared with the T cell responses of patients with active RA using HCgp-39 epitopes defined in HLA-DR4 transgenic mice. RESULTS: CD4+ T cells from DRalphabeta1*0401 and DRalphabeta1*0402 transgenic mice identified completely different immunodominant peptide epitopes of HCgp-39, and this was not explained by known DR4-binding motifs or direct peptide-binding studies. DRalphabeta1*0401-restricted, antigen-specific T cells produced significantly more interferon-gamma and tumor necrosis factor a in response to HCgp-39 than did T cells from DRalphabeta1*0402 transgenic mice. Finally, HCgp-39 peptides defined in DRalphabeta1*0401 transgenic mice stimulated T cells from HLA-DR4 positive human subjects and RA patients, but not T cells from HLA-DR4 negative individuals. CONCLUSION: T cell epitopes of HCgp-39 that were defined in HLA-DR4 transgenic mice stimulated T cells from human subjects carrying RA-associated HLA-DR4 alleles. HLA-DR4 molecules may influence the disease process in RA both by presentation of selected peptide epitopes and by promoting the production of proinflammatory cytokines in synovial joints.  (+info)

Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity. (4/819)

OBJECTIVE: YKL-40, also called human cartilage glycoprotein-39, is secreted by chondrocytes, synovial cells, macrophages and neutrophils. Studies have shown that YKL-40 is an autoantigen in rheumatoid arthritis (RA). We evaluated whether serum YKL-40 was related to disease activity in patients with RA. METHODS: Serum YKL-40 was determined by radioimmunoassay in 156 patients with RA during a 1 yr longitudinal study. RESULTS: Serum YKL-40 was increased in 54% of the patients with clinically active disease. Patients with clinically active disease initially who became inactive after 12 months had a significant decrease in serum YKL-40 (-30%, P < 0.002) and patients who changed from inactive to active disease had an increase in serum YKL-40. Patients who remained active had unchanged serum YKL-40 during the study. Serum YKL-40 decreased rapidly (-24% after 7 days, P < 0.01) during prednisolone therapy, and more slowly in patients treated with methotrexate only (-15% after 60 days, P < 0.01). Patients with early RA (disease duration < 3 yr, n = 50) and a persistently elevated serum YKL-40 were at risk of radiological disease progression as determined by Larsen score. CONCLUSION: Serum YKL-40 varies according to disease activity in RA, but provides in some respect information different from conventional markers. Our previous studies are consistent with a local release of YKL-40 in the arthritic joint followed by a secondary increase in serum YKL-40. YKL-40 may prove to be a new tool for the study of disease activity and pathophysiology of RA.  (+info)

YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization. (5/819)

The serum concentration of YKL-40, a matrix protein of specific granules in neutrophils, was determined by RIA in 90 patients hospitalized with pneumonia of suspected bacterial origin. Of these, 64 were followed prospectively during antibiotic treatment with blood samples taken on day 0 (on admission and the start of treatment) and on days 1, 3, 5, 7, 10, and 21. Serum YKL-40 at admission was increased in patients with Streptococcus pneumoniae pneumonia (median, 893 microgram/L; 95% confidence interval [CI], 704-1560), compared with healthy subjects (median, 102 microgram/L; 95% CI, 64-247 microgram/L; P<.001) and in patients with pneumonia of unknown etiology (median, 448 microgram/L; 95% CI, 334-700; P<.05). Peak YKL-40 serum values were observed on day 1 and thereafter declined steeply to almost normal by day 3. During the first 10 days, there was a close relation between serum YKL-40 and markers of specific granules of neutrophils (serum lactoferrin and neutrophil gelatinase-associated lipocalin), which suggests that serum YKL-40 reflects exocytosis of specific granules of neutrophils in persons with acute bacterial pneumonia.  (+info)

YKL-40 in giant cells and macrophages from patients with giant cell arteritis. (6/819)

OBJECTIVE: YKL-40, a mammalian member of the family 18 glycosyl hydrolases, is secreted by activated macrophages at a late stage of differentiation. Macrophages are present in inflammation of the arterial wall and are thought to participate in the pathogenesis of giant cell arteritis (GCA). The aim of this study was to evaluate whether macrophages and giant cells of patients with GCA produce YKL-40, and whether serum YKL-40 concentrations are elevated in these patients. METHODS: Serum YKL-40 was determined by radioimmunoassay in 19 patients with GCA and 8 patients with polymyalgia rheumatica (PMR) who were followed up prospectively during 1 year of treatment with prednisolone. Immunohistochemical staining for YKL-40 was performed in temporal artery biopsy samples that were obtained before treatment. RESULTS: In the arteritic vessels of patients with GCA, positive staining for the YKL-40 antigen was found in CD68+ giant cells and mononuclear cells located in the media. Macrophages located in the adventitia and intima were negative for YKL-40. At the time of diagnosis, patients with GCA had an increased median serum level of YKL-40 (256 microg/liter; P<0.01) compared with healthy age-matched controls (median 118 microg/liter), and the serum level of YKL-40 decreased to normal levels during prednisolone treatment (-38% after 1 month; P<0.001). Most patients with PMR had normal serum YKL-40 levels (median 158 microg/liter) and had no changes in the serum YKL-40 levels during prednisolone treatment. The observed changes in serum YKL-40 did not always parallel the changes in serum C-reactive protein levels and erythrocyte sedimentation rate during the 1-year study period. CONCLUSION: YKL-40 is found in CD68+ giant cells and mononuclear cells in the media of arteritic vessels of patients with GCA, and the concentration of serum YKL-40 may reflect the local activity of these cells in the inflamed artery.  (+info)

Induction of tolerance with intranasal administration of human cartilage gp-39 in DBA/1 mice: amelioration of clinical, histologic, and radiologic signs of type II collagen-induced arthritis. (7/819)

OBJECTIVE: Human cartilage glycoprotein 39 (HC gp-39) was recently identified as a candidate autoantigen in the pathogenesis of rheumatoid arthritis. In the present studies, we investigated the capacity of HC gp-39 to interfere in clinical disease induced by an unrelated autoantigen, type II collagen (CII), by the induction of cross-tolerance. METHODS: DBA-1j/Bom mice were immunized with bovine CII/complete Freund's adjuvant and were given intraperitoneal booster injections of CII on day 21. Tolerance was induced via the intranasal pathway with either the disease-inducing antigen (CII), a control antigen (ovalbumin), or HC gp-39 either before priming with CII or near the day of the booster injection. Arthritis was monitored visually, and joint pathology was examined histologically and radiologically. In addition, CII antibody levels in serum were analyzed by enzyme-linked immunosorbent assay. RESULTS: In contrast to treatment before priming, intranasal application of HC gp-39 after immunization markedly suppressed disease activity and prevented joint destruction, whereas application of ovalbumin or CII was ineffective. Interference of HC gp-39 with the immune response to CII was demonstrated by decreased anti-CII antibody levels. The combined data indicate that intranasal treatment with HC gp-39 may trigger modulatory or regulatory mechanisms that interfere with the expression of disease in murine collagen-induced arthritis. CONCLUSION: HC gp-39 is the first cross-tolerance-inducing protein in arthritis that down-modulates a spectrum of disease features when given in a semitherapeutic protocol.  (+info)

Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization. (8/819)

OBJECTIVE: To examine the expression pattern of human cartilage glycoprotein 39 (HC gp-39) mRNA in human cartilage and bone. DESIGN: In-situ hybridization analysis was used to examine the expression pattern of human cartilage glycoprotein 39 (HC gp-39) mRNA in adult human osteoarthritic articular cartilage from various stages of disease, as well as in human osteophytic tissue and in human fetal bone. RESULTS: In cartilage from patients with mild osteoarthritic cartilage degeneration, HC gp-39 was expressed at moderate to high levels only in chondrocytes of the superficial zone. In advanced OA cartilage, cloning chondrocytes of the superficial zone expressed high levels of HC gp-39 and chondrocytes of the mid- and deep zones were also positive. HC gp-39 was undetectable in the chondrocytes of normal articular cartilage. In osteophytic tissue, the expression of HC gp-39 mRNA was intense in flattened, end-stage osteoblasts and in primary osteocytes in both endochondral and intramembranous bone formation. Proliferating osteoblasts expressed low to moderate levels. Notably, mature osteocytes were negative for HC gp-39 expression. Chondrocytes in the secondary ossification center of developing fetal cartilage demonstrated high expression while growth plate and mineralized cartilage chondrocytes had lower expression. Osteoblasts at sites of endochondral and intramembranous bone formation were positive for expression of HC gp-39. CONCLUSIONS: The stage-specific expression of HC gp-39 in fetal development and adult remodelling bone and cartilage provides evidence for a specific functional or structural role for HC gp-39 in bone and cartilage tissue. HC gp-39 is expressed in diseased human osteoarthritic cartilage and osteophyte, but not in non-diseased tissue, and its distribution within the tissue changes as disease progresses. OA is characterized not only by cartilage degeneration, but by increased subchondral bone formation and osteophytosis. The results from this study indicate that the increased HC gp-39 expression in OA serum and synovial fluid may reflect not only cartilage degeneration but increased osteogenesis.  (+info)

Serum adipokine and inflammatory markers before and after liver transplantation in recipients with major cardiovascular events<...
TY - JOUR. T1 - Serum adipokine and inflammatory markers before and after liver transplantation in recipients with major cardiovascular events. AU - Watt, Kymberly D.. AU - Fan, Chun. AU - Therneau, Terry. AU - Heimbach, Julie K.. AU - Seaberg, Eric C.. AU - Charlton, Michael R.. PY - 2014/7. Y1 - 2014/7. N2 - In the nontransplant setting, aberrant serum adipokine levels are associated with cardiovascular (CV) disease. The effects of liver transplantation (LT) on serum adipokine levels and their association with post-LT CV disease have not been studied. A nested case-control study of 77 patients with major CV events more than 4 months after LT analyzed serum adiponectin, resistin, leptin, C-reactive protein, and apolipoprotein levels measured before transplantation and 4, 12, and 24 months after LT. Adiponectin and resistin levels decreased dramatically after LT in all patients. Recipients with CV disease had lower levels of adiponectin and higher levels of resistin, leptin, C-reactive protein, ...
https://mayoclinic.pure.elsevier.com/en/publications/serum-adipokine-and-inflammatory-markers-before-and-after-liver-t
Adipokines in Plasma and Breast Tissues: Associations with Breast Cancer Risk Factors | Cancer Epidemiology, Biomarkers &...Adipokines in Plasma and Breast Tissues: Associations with Breast Cancer Risk Factors | Cancer Epidemiology, Biomarkers &...
In this first report of adipokine concentrations in histologically normal breast tissues from healthy women, it was found that there was wide interindividual variation in breast leptin and adiponectin, inferring the potential for these adipokines to be associated with breast cancer in some women but not others. Importantly, we observed modest positive correlations between plasma and breast adipokine concentrations, which for leptin was the strongest in women with BMI less than 25, whereas for adiponectin, the correlation was strongest in those with BMI ≥30 or more. Therefore, it is uncertain whether or not plasma adipokines are good surrogates for breast adipokines among all women. Through multivariable-adjusted regression analysis, we identified factors that explain 20% to 30% of the variation in breast leptin and adiponectin. Among all of the breast cancer risk factors investigated in this study, we found that BMI and race explained most of the observed variation in breast leptin, whereas OC ...
http://cebp.aacrjournals.org/content/21/10/1745?rss=1
Adipokines as key players in β cell function and failure | Clinical Science | Portland PressAdipokines as key players in β cell function and failure | Clinical Science | Portland Press
The growing prevalence of obesity and its related metabolic diseases, mainly Type 2 diabetes (T2D), has increased the interest in adipose tissue (AT) and its role as a principal metabolic orchestrator. Two decades of research have now shown that ATs act as an endocrine organ, secreting soluble factors termed adipocytokines or adipokines. These adipokines play crucial roles in whole-body metabolism with different mechanisms of action largely dependent on the tissue or cell type they are acting on. The pancreatic β cell, a key regulator of glucose metabolism due to its ability to produce and secrete insulin, has been identified as a target for several adipokines. This review will focus on how adipokines affect pancreatic β cell function and their impact on pancreatic β cell survival in disease contexts such as diabetes. Initially, the classic adipokines will be discussed, followed by novel secreted adipocyte-specific factors that show therapeutic promise in regulating the adipose-pancreatic ...
https://portlandpress.com/clinsci/article-abstract/133/22/2317/221329/Adipokines-as-key-players-in-cell-function-and?redirectedFrom=fulltext
Adipokines as key players in β cell function and failure | Clinical Science | Portland PressAdipokines as key players in β cell function and failure | Clinical Science | Portland Press
The growing prevalence of obesity and its related metabolic diseases, mainly Type 2 diabetes (T2D), has increased the interest in adipose tissue (AT) and its role as a principal metabolic orchestrator. Two decades of research have now shown that ATs act as an endocrine organ, secreting soluble factors termed adipocytokines or adipokines. These adipokines play crucial roles in whole-body metabolism with different mechanisms of action largely dependent on the tissue or cell type they are acting on. The pancreatic β cell, a key regulator of glucose metabolism due to its ability to produce and secrete insulin, has been identified as a target for several adipokines. This review will focus on how adipokines affect pancreatic β cell function and their impact on pancreatic β cell survival in disease contexts such as diabetes. Initially, the classic adipokines will be discussed, followed by novel secreted adipocyte-specific factors that show therapeutic promise in regulating the adipose-pancreatic ...
https://portlandpress.com/clinsci/article-abstract/133/22/2317/221329/Adipokines-as-key-players-in-cell-function-and
Adipokines: A gear shift in pubertyAdipokines: A gear shift in puberty
In this review, we discuss the role of adipokines in the onset of puberty in children with obesity during adrenarche and gonadarche and provide a clear and detailed overview of the biological processes of two major players, leptin and adiponectin. Adipokines, especially leptin and adiponectin, seem to induce an early onset of puberty in girls and boys with obesity by affecting the hypothalamic-pituitary-gonadal (HPG) axis. Moreover, adipokines and their receptors are expressed in the gonads, suggesting a role in sexual maturation and reproduction. All in all, adipokines may be a clue in understanding mechanisms underlying the onset of puberty in childhood obesity and puberty onset variability ...
https://repository.ubn.ru.nl/handle/2066/220685
Repositorio da Producao Cientifica e Intelectual da Unicamp: Adipokines: Novel Players In Resistant HypertensionRepositorio da Producao Cientifica e Intelectual da Unicamp: Adipokines: Novel Players In Resistant Hypertension
Resistant hypertension (RH) is a multifactorial disease, frequently associated with obesity and characterized by blood pressure above goal (140/90 mm Hg) despite the concurrent use of ≥3 antihypertensive drugs of different classes. The mechanisms of obesity-related hypertension include, among others, aldosterone excess and inflammatory adipokines, which have demonstrated a significant role in the pathogenesis of metabolic syndrome and RH. This review aims to summarize recent studies on the role of the adipokines leptin, resistin, and adiponectin in the pathophysiology of RH and target-organ damage associated with this condition. The deregulation of adipokine levels has been associated with clinical characteristics frequently recognized in RH such as diabetes, hyperactivity of sympathetic and renin-angiotensin-aldosterone systems, and vascular and renal damage. Strategies to regulate adipokines may be promising for the management of RH and some clinical implications must be considered when ...
http://repositorio.unicamp.br/jspui/handle/REPOSIP/86372
The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose TissueThe Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue
Obesity is recognized as a risk factor for lifestyle-related diseases such as type 2 diabetes and cardiovascular disease. White adipose tissue (WAT) is not only a static storage site for energy; it is also a dynamic tissue that is actively involved in metabolic reactions and produces humoral factors, such as leptin and adiponectin, which are collectively referred to as adipokines. Additionally, because there is much evidence that obesity-induced inflammatory changes in WAT, which is caused by dysregulated expression of inflammation-related adipokines involving tumor necrosis factor-|i|α|/i| and monocyte chemoattractant protein 1, contribute to the development of insulin resistance, WAT has attracted special attention as an organ that causes diabetes and other lifestyle-related diseases. Exercise training (TR) not only leads to a decrease in WAT mass but also attenuates obesity-induced dysregulated expression of the inflammation-related adipokines in WAT. Therefore, TR is widely used as a tool for
https://www.hindawi.com/journals/ije/2013/801743/
Invited review - Physiological roles of adipokines, hepatokines, and myokines in ruminants<...
TY - JOUR. T1 - - Invited review - Physiological roles of adipokines, hepatokines, and myokines in ruminants. AU - Roh, Sang Gun. AU - Suzuki, Yutaka. AU - Gotoh, Takafumi. AU - Tatsumi, Ryuichi. AU - Katoh, Kazuo. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Since the discovery of leptin secreted from adipocytes, specialized tissues and cells have been found that secrete the several peptides (or cytokines) that are characterized to negatively and positively regulate the metabolic process. Different types of adipokines, hepatokines, and myokines, which act as cytokines, are secreted from adipose, liver, and muscle tissue, respectively, and have been identified and examined for their physiological roles in humans and disease in animal models. Recently, various studies of these cytokines have been conducted in ruminants, including dairy cattle, beef cattle, sheep, and goat. Interestingly, a few cytokines from these tissues in ruminants play an important role in the post-parturition, lactation, and fattening ...
https://kyushu-u.pure.elsevier.com/en/publications/invited-review-physiological-roles-of-adipokines-hepatokines-and-
Signalling role of adipose tissue: adipokines and inflammation in obesitySignalling role of adipose tissue: adipokines and inflammation in obesity
White adipose tissue (WAT) is a major endocrine and secretory organ, which releases a wide range of protein signals and factors termed adipokines. A number of adipokines, including leptin, adiponectin, tumour necrosis factor alpha, IL-1beta (interleukin 1beta), IL-6, monocyte chemotactic protein-1, …
https://pubmed.ncbi.nlm.nih.gov/16246049/?dopt=Abstract
03 | June | 2017 | Evolution of NADPH Oxidase Inhibitors03 | June | 2017 | Evolution of NADPH Oxidase Inhibitors
Obese states seen as a chronic inflammation are closely linked to the development of metabolic dysfunction. MAPK inhibitor SB203580 blocked the inhibitory effects of TNF on adipolin and KLF15 expression. These data suggest that adipose inflammation under conditions of obesity suppresses adipolin expression via JNK-dependent down-regulation of KLF15 in adipocytes. Introduction Obesity is closely associated with the development of various metabolic disorders including insulin resistance and type 2 diabetes [1]C[3]. Recent evidence indicates that chronic low-grade inflammation contributes to the pathogenesis of numerous obesity-related diseases such as atherosclerosis and insulin resistance [4]C[7]. Adipose tissue secretes numerous biologically active proteins, also known as adipokines. Lots of the adipokines, including TNF, IL6 and MCP-1, promote irritation and metabolic dysfunction, whereas a small amount of adipokines possess helpful activities on inflammatory fat burning capacity and procedures ...
http://biobeds.info/2017/06/03/
Fehér Ágnes - ODT Személyi adatlapFehér Ágnes - ODT Személyi adatlap
Pákáski M, Fehér Á, Juhász A, Drótos G, Fazekas ÖC, Kovács J, Janka Z, Kálmán J: Serum adipokine levels modified by donepezil treatment in Alzheimers disease., JOURNAL OF ALZHEIMERS DISEASE 38: (2) pp. 371-377. Paper DOI: 10.3233/JAD-131139 ...
https://doktori.hu/index.php?menuid=192&lang=HU&sz_ID=11237
sj-pdf-1-lup-10.1177 0961203320935185 - Supplemental material for Insulin resistance and serum levels of adipokines in patients...
Kuo, C. (Contributor), Tsai, T. (Contributor), Huang, Y. (Contributor) (Aug 1 2020). sj-pdf-1-lup-10.1177_0961203320935185 - Supplemental material for Insulin resistance and serum levels of adipokines in patients with systemic lupus erythematosus: a systematic review and meta-analysis. Unknown Publisher. 10.25384/sage.12600715.v1 ...
https://tmu.pure.elsevier.com/en/datasets/sj-pdf-1-lup-1011770961203320935185-supplemental-material-for-ins-3
Changes in protein levels of adipokines in 3T3-L1 cells | Open-iChanges in protein levels of adipokines in 3T3-L1 cells | Open-i
Changes in protein levels of adipokines in 3T3-L1 cells treated with HCV core protein.(A) The protein level of IL-6 was significantly increased, and the protein
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4487891_pone.0131346.g002&req=4
IntechOpen Open Access Publisher - Open Science Open Minds | IntechOpenIntechOpen Open Access Publisher - Open Science Open Minds | IntechOpen
Adipose Tissue Inflammation and Metabolic Disorders. By Felipe Henriques, Alexander H. Bedard and Miguel Luiz Batista Júnior. Adipose tissue not only possesses an important role in the storage of excess nutrients but also acts as a critical immune and endocrine organ. Researchers and clinicians now consider adipose tissue to be an active endocrine organ that secretes various humoral factors called adipokines, which imparts important systemic metabolic effects, from food intake to glucose tolerance. Along with its production of specialized adipokines, adipose tissue also secretes proinflammatory cytokines that likely contributes to the low-level systemic inflammation that has become a hallmark of various metabolic syndrome-associated chronic pathologies, such as obesity and cancer cachexia. These systemic effects may be mediated by communication networks arising from the multitude of resident adipose cells, including adipocytes, endothelial cells, neuronal cells, stem cells and other ...
https://www.intechopen.com/profiles/309605/alexander-h.-bedard
Adipocytokines and pituitary function
It is widely accepted that, in addition to serving as a repository for energy reserves, adipose tissue is an active endocrine organ that secretes a variety of signalling molecules, the adipokines, which play important roles in the regulation of metabolism, energy balance, feeding behaviour, vascular homeostasis and immunity. In particular, leptin, resistin and adiponectin have been implicated in energy and glucose homeostasis. Additional neuroendocrine functions have also been recognized for leptin as it regulates the secretion of pituitary GH and LH. In order to elucidate whether adiponectin, as leptin, may be involved in the regulation of pituitary cell function, we investigated the effect of this adipokine on somatotrophs and gonadotrophs and analyzed its interaction with major stimulatory regulators of these cells (ghrelin, GHRH, GnRH), as well as with their corresponding receptors (GHS-R, GHRH-R, and GnRH-R, respectively). Results show that adiponectin inhibits GH and LH secretion as well ...
http://www.endocrine-abstracts.org/ea/0014/ea0014s19.4.htm
Science of Weight Loss: The fat Resistance Diet | ENCOGNITIVE.COMScience of Weight Loss: The fat Resistance Diet | ENCOGNITIVE.COM
The discovery of leptin in 1994 revolutionized the scientific understanding of fat. Scientists and physicians used to think that body fat was simply an inert storehouse of unused calories. From that perspective, weight management should be a simple matter--exercise more, eat less, and the pounds will drop. We now know that obesity and its related problems are not just about pounds; theyre about hormones like leptin that are produced by fat. These hormones are called adipokines, and they tell us that fat is not just an inert repository of unused calories. It is a living organ, as biochemically active as the heart or kidneys or liver. Through the actions of adipokines, excess fat by itself can cause high blood pressure, diabetes, heart attacks, cancer, strokes, and arthritis. More importantly, fat regulates itself by producing adipokines that can increase or decrease appetite and metabolic rate.. Leptin was the first adipokine to be discovered. Scientists at Rockefeller University found that ...
http://www.encognitive.com/node/3890
Forskolin Inhibits Lipopolysaccharide-Induced Modulation of MCP-1 and GPR120 in 3T3-L1 Adipocytes Through an Inhibition of NFκB...Forskolin Inhibits Lipopolysaccharide-Induced Modulation of MCP-1 and GPR120 in 3T3-L1 Adipocytes Through an Inhibition of NFκB...
In an obese state, Toll-like receptor-4 (TLR-4) upregulates proinflammatory adipokines secretion including monocyte chemotactic protein-1 (MCP-1) in adipose tissue. In contrast, G-protein coupled receptor 120 (GPR120) mediates antiobesity effects. The aim of this study was to determine the signaling …
https://pubmed.ncbi.nlm.nih.gov/27881903/
DiVA - Search resultDiVA - Search result
OBJECTIVE:. The role of adipokines in the regulation of energy substrate production in non-diabetic pregnant women has not been elucidated. We hypothesize that serum concentrations of adiponectin are related to fetal growth via maternal fat mass, insulin resistance and glucose production, and further, that serum levels of leptin are associated with lipolysis and that this also influences fetal growth. Hence, we investigated the relationship between adipokines, energy substrate production, insulin resistance, body composition and fetal weight in non-diabetic pregnant women in late gestation.. STUDY DESIGN:. Twenty pregnant women with normal glucose tolerance were investigated at 36 weeks of gestation at Uppsala University Hospital. Levels of adipokines were related to rates of glucose production and lipolysis, maternal body composition, insulin resistance, resting energy expenditure and estimated fetal weights. Rates of glucose production and lipolysis were estimated by stable isotope dilution ...
http://uu.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22organisationId%22%3A%2211254%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=
Adipokines in Autism - Inflammation | asdresearchinitiativeAdipokines in Autism - Inflammation | asdresearchinitiative
Changes in Adipokine Levels in Autism Spectrum Disorders. http://www.ncbi.nlm.nih.gov/pubmed/24401207 Abstract Background and Objective: The etiopathogenesis of autism spectrum disorders (ASD) is largely unknown, but it seems to involve dysfunction in several biological systems. Among many possible biological pathways, the immune system has emerged as potentially involved. Recent studies have shown association between cytokines (molecules that…
https://asdresearchinitiative.wordpress.com/2014/01/12/2978/
Adipolin/FAM132A Antibodies: Novus BiologicalsAdipolin/FAM132A Antibodies: Novus Biologicals
Adipolin/FAM132A Antibodies available through Novus Biologicals. Browse our Adipolin/FAM132A Antibodies all backed by our Guarantee+.
https://www.novusbio.com/primary-antibodies/adipolin-fam132a?species=Human
WAT rhythms
Supervisors: Andries Kalsbeek & Eric Fliers. Adiposity is the most important risk factor for the development of insulin resistance and type 2 diabetes mellitus. In addition, it is also possible to reduce the amount of insulin in the body.. Adipose tissue is an important endocrine organ. It is involved in the regulation of energy metabolism by secreting factors (adipokines) that regulates appetite, food intake, glucose, and energy expenditure. Many of these adipokines display profound day / night rhythms, and accumulating evidence links disruption of these rhythms to metabolic diseases as well as obesity and type 2 diabetes. In the case of a neurological disorder of the brain, there is a difference between the brain and the brain, and the hypothalamus of the brain WAT functions.. The present proposal is based on the assumption that the WAT is circadian, metabolic and endocrine functions.. ...
http://kalsbeekgroup.nl/wat-rhythms.html
Adipose Tissue And Adipokines In Health And Disease (Nutrition And Health) (Hardcover)
ISBN: 9781588297211. Author : Fantuzzi Giamila Year: Apr 27 2007. Pages: 400. Size: 7 x 0.9 x 10 inches. Publisher Name: Humana Press. ...
http://www.siplind.com/index.php?route=product/product&path=28&product_id=2670
Political News | Irish & International Politics | The Irish TimesPolitical News | Irish & International Politics | The Irish Times
Read the latest Political News headlines, brought to you daily from Irelands Definitive Brand of Quality News. Read the Irish Times Online.
https://www.irishtimes.com/news/politics
Adipose tissue quantity and composition contribute to adipokine concentrations in the subclavian vein and the inferior...
BACKGROUND: Adipose tissue dysfunction is associated with inflammation, type 2 diabetes mellitus and vascular diseases. Visceral adipose tissue (VAT)-derived adipokines, which are released in the portal circulation may influence liver metabolism. OBJECTIVES: (1) To estimate the contribution of VAT and subcutaneous adipose tissue (SAT) on adipokine levels by measuring differences in adipokine concentrations between the portal draining inferior mesenteric vein and the subclavian vein. (2) To determine the relation of both VAT and SAT quantity and composition to mesenteric and systemic concentrations of adipokines. DESIGN: Cross-sectional cohort study. SUBJECTS: A total of 32 patients undergoing abdominal aortic surgery. MEASUREMENTS: A panel of 18 adipokines was measured in perioperatively obtained blood samples from the subclavian vein and the inferior mesenteric vein. Adipocyte size, macrophage infiltration and capillary density were measured in subcutaneous and mesenteric adipose tissue biopsies; SAT
https://www.kennedy.ox.ac.uk/publications/1108991
The adipokines in the pathogenesis and treatment of nonalcoholic fatty liver disease - hippokratia.grThe adipokines in the pathogenesis and treatment of nonalcoholic fatty liver disease - hippokratia.gr
Abstract. Insulin resistance, abdominal obesity, and inflammation play important roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Several adipokines, particularly adiponectin but also leptin, resistin, irisin, ghrelin, and visfatin modulate these pathogenetic mechanisms and appear to play a role in the development of hepatic steatosis and the progression to steatohepatitis and cirrhosis. Accordingly, these adipokines might represent attractive targets in patients with NAFLD. Notably, both lifestyle changes and many pharmacological agents that are used in the management of NAFLD, particularly pioglitazone and statins, exert favorable effects on adipokine levels. However, it is unclear whether these effects play a role in the improvement in liver histology. Therefore, mechanistic studies are needed to clarify the contribution of changes in adipokine levels to the effects of these interventions on hepatic steatosis, inflammation, and fibrosis. In parallel, the development of ...
https://www.hippokratia.gr/2019/02/28/the-adipokines-in-the-pathogenesis-and-treatment-of-nonalcoholic-fatty-liver-disease/
Supplementary Figure 1. mrna expression of chitinase and chitinase-like protein in splenic immune cells. Each splenic immune...Supplementary Figure 1. mrna expression of chitinase and chitinase-like protein in splenic immune cells. Each splenic immune...
Supplementary Figure 1. mrna expression of chitinase and chitinase-like protein in splenic immune cells. Each splenic immune cell population was sorted by FACS. Surface markers for sorting were CD11c +
http://healthdocbox.com/Aids_and_Hiv/73854262-Supplementary-figure-1-mrna-expression-of-chitinase-and-chitinase-like-protein-in-splenic-immune-cells-each-splenic-immune-cell-population-was.html
北京大学医学部机构知识库([email protected]): Human Secreted Stabilin-1-Interacting Chitinase-like Protein Aggravates the Inflammation Associated...
Objective. To study the relationship between the human secreted protein stabilin-1-interacting chitinase-like protein (SI-CLP) and rheumatoid arthritis (RA).. Methods. The expression of SI-CLP in peripheral blood mononuclear cells (PBMCs) and synovial fluid from patients with RA and the effects of cytokines on SI-CLP expression were examined by Western blotting. Fluorescence-activated cell sorting analysis was performed to investigate the binding between SI-CLP and cells. Bone marrow-derived macrophages were isolated from wild-type and SI-CLP-/- mice, and real-time quantitative polymerase chain reaction was performed to detect the levels of messenger RNA for cytokines or SI-CLP in SI-CLP- or cytokine-treated macrophages. Histologic studies were conducted to evaluate inflamma-tion and the expression of interleukin-12 (IL-12), IL-13, and SI-CLP in lesions. Enzyme-linked immunosorbent assays were used to detect the cytokine levels in bone marrow-derived macrophages. Rats or mice with ...
http://ir.bjmu.edu.cn/handle/400002259/67317
Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies | BMC Cancer | Full TextAssociation between adipokines and thyroid carcinoma: a meta-analysis of case-control studies | BMC Cancer | Full Text
The incidence of thyroid carcinoma is increasing all over the world. Some studies have suggested that the change of adipokines expression can induce thyroid carcinoma. However, other studies have come to the opposite conclusion. Therefore, we studied the relationship between adipokines and thyroid carcinoma. Databases-PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries were searched. A meta-analysis was then performed through a fixed or random-effects model to calculate I values for heterogeneity analysis. Twenty-nine articles were finally included for analysis. The level of serum tumor necrosis factor-alpha (TNF-α) [standardized mean difference (SMD) =1.31, 95% confidence interval (95% CI): 0.35 to 2.28, I2 = 98%, P = 0.008] and the ratio of TNF-α immunoreactivity in tissues [odds ratios (OR) =6.36, 95% CI: 1.92 to 21.05, I2 = 66%, P = 0.002] in thyroid carcinoma are significantly higher than those in control. The serum interleukin-6 (IL-6) in patients with thyroid
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-020-07299-x
5-Lipoxygenase Activating Protein Signals Adipose Tissue Inflammation and Lipid Dysfunction in Experimental Obesity | The...5-Lipoxygenase Activating Protein Signals Adipose Tissue Inflammation and Lipid Dysfunction in Experimental Obesity | The...
The presence of the so-called low-grade inflammatory state is recognized as a critical event in adipose tissue dysfunction, leading to altered secretion of adipokines and free fatty acids (FFAs), insulin resistance, and development of hepatic complications associated with obesity. This study was designed to investigate the potential contribution of the proinflammatory 5-lipoxygenase (5-LO) pathway to adipose tissue inflammation and lipid dysfunction in experimental obesity. Constitutive expression of key components of the 5-LO pathway, as well as leukotriene (LT) receptors, was detected in adipose tissue as well as in adipocyte and stromal vascular fractions. Adipose tissue from obese mice, compared with that from lean mice, exhibited increased 5-LO activating protein (FLAP) expression and LTB4 levels. Incubation of adipose tissue with 5-LO products resulted in NF-κB activation and augmented secretion of proinflammatory adipokines such as MCP-1, IL-6, and TNF-α. In addition, LTB4, but not ...
http://www.jimmunol.org/content/early/2010/03/05/jimmunol.0901355
op.7d.10] the Effect of Renal Denervation on Adipokines in Patients with Resistant Hypertension. - Semantic Scholarop.7d.10] the Effect of Renal Denervation on Adipokines in Patients with Resistant Hypertension. - Semantic Scholar
OBJECTIVE We have previously demonstrated the effectiveness of renal denervation (RDN) to lower blood pressure (BP) at least partially via the reduction of sympathetic stimulation to the kidney. Obesity also contributes to hypertension. A number of adipocyte-derived factors (collectively termed adipokines) have been implicated in BP control. The aim of this study was to examine the effect of RDN on adipokines. In particular, whether BP reduction, associated with RDN treatment, has a favourable outcome on adipokine profile in patients with resistant hypertension (RH). DESIGN AND METHOD Fifty seven patients with RH undergoing RDN have been recruited for the study (65% males, age 60.8 ± 1.5 years, BMI 32.6 ± 0.7 kg/m, mean ± SEM). At recruitment the patients were on an average of 4.8 ± 2.1 antihypertensive drugs and were asked to refrain from changing their medication regimen for the duration of the study. Automated seated office BP measurements were taken with an Omron HEM-705 monitor at baseline
https://www.semanticscholar.org/paper/op-7d-10-the-Effect-of-Renal-Denervation-on-Adipo-Eikelis-Hering/08b2e88d98adb3a5a92eb9dce220fe7186da24bd
Perivascular adipose tissue as a regulator of vascular disease pathogenesis: identifying novel therapeutic targets. - Radcliffe...Perivascular adipose tissue as a regulator of vascular disease pathogenesis: identifying novel therapeutic targets. - Radcliffe...
Adipose tissue (AT) is an active endocrine organ with the ability to dynamically secrete a wide range of adipocytokines. Importantly, its secretory profile is altered in various cardiovascular disease states. AT surrounding vessels, or perivascular AT (PVAT), is recognized in particular as an important local regulator of vascular function and dysfunction. Specifically, PVAT has the ability to sense vascular paracrine signals and respond by secreting a variety of vasoactive adipocytokines. Due to the crucial role of PVAT in regulating many aspects of vascular biology, it may constitute a novel therapeutic target for the prevention and treatment of vascular disease pathogenesis. Signalling pathways in PVAT, such as those using adiponectin, H2 S, glucagon-like peptide 1 or pro-inflammatory cytokines, are among the potential novel pharmacological therapeutic targets of PVAT. LINKED ARTICLES: This article is part of a themed section on Molecular Mechanisms Regulating Perivascular Adipose Tissue - Potential
https://www.rdm.ox.ac.uk/publications/666532
Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle...
TY - JOUR. T1 - Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K+ Channels. AU - Noblet, Jillian N.. AU - Owen, Meredith K.. AU - Goodwill, Adam G.. AU - Sassoon, Daniel J.. AU - Tune, Johnathan. PY - 2015/6/27. Y1 - 2015/6/27. N2 - Objective - The effects of coronary perivascular adipose tissue (PVAT) on vasomotor tone are influenced by an obese phenotype and are distinct from other adipose tissue depots. The purpose of this investigation was to examine the effects of lean and obese coronary PVAT on end-effector mechanisms of coronary vasodilation and to identify potential factors involved. Approach and Results - Hematoxylin and eosin staining revealed similarities in coronary perivascular adipocyte size between lean and obese Ossabaw swine. Isometric tension studies of isolated coronary arteries from Ossabaw swine revealed that factors derived from lean and obese coronary PVAT attenuated vasodilation to adenosine. ...
https://indiana.pure.elsevier.com/en/publications/lean-and-obese-coronary-perivascular-adipose-tissue-impairs-vasod
Plus itPlus it
Background: Investigation of immunopathogenetic mechanisms of obesity associated asthma may demonstrate novel therapeutic targets.. Objective: The aim of this study was to compare levels of Th1, Th2, Treg and Th17 cytokines secreted by peripheral mononuclear cell culture (PBMC) in response to nonspecific stimulation in obese and nonobese children with asthma.. Methods: Obese and nonobese children with asthma aged 5 to 16 were enrolled into this case-control study consecutively. Age at asthma diagnosis and clinical severity were recorded. Skin prick test was performed. Serum adipokine levels as well as PBMC supernatant IL-4, IL-10, IL-17, IL-23, IFNγ and TGF-β levels were measured.. Results: Mean (± standard deviation) ages of obese (n=28) and nonobese (n=39) children with asthma were 8.7 ± 2.9 and 10.5 ± 3.2 respectively. Asthma symptom score was higher and age at asthma diagnosis was lower in obese compared to nonobese children with asthma (p=0.03 and p=0.004 respectively). Leptin levels ...
http://erj.ersjournals.com/content/40/Suppl_56/P1100
OP68 How is overweight/obesity across the life course associated with levels of adipokines, inflammatory and endothelial...OP68 How is overweight/obesity across the life course associated with levels of adipokines, inflammatory and endothelial...
Results Overweight showed consistent positive associations with leptin, CRP, IL-6, E-selectin and t-PA and inverse associations with adiponectin; vWF was not consistently related across age. In age and sex-adjusted models fitted separately for each age, being overweight at 11 years and onwards was associated with adverse levels of adipokines and inflammatory markers and being overweight from 15 and onwards for endothelial markers. For CRP and adiponectin, an earlier association with overweight at 2 years was also apparent. Adjustment for overweight at age 60-64 years reduced all overweight associations at earlier ages, entirely explaining those for E-selectin and t-PA, but only partly explaining those for leptin, adiponectin, CRP and IL-6. An accumulation model best described the associations between overweight across the life course with adiponectin (mean percentage difference [95% CI] for each additional time overweight at age 15, 36 and 60-64: -12.8% [-16.3%, -9.1%], leptin: 60.2% [53.6%, ...
http://jech.bmj.com/content/68/Suppl_1/A34.3
Changes in adipokine levels before intravenous immunogl | Open-iChanges in adipokine levels before intravenous immunogl | Open-i
Changes in adipokine levels before intravenous immunoglobulin (IVIG) infusion, at 48 hr after IVIG infusion and in the convalescent phase in Kawasaki disease pa
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4214939_jkms-29-1385-g001&req=4
Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins - Research - The Capital Region...
1) Background: Zinc is an essential micronutrient and zinc deficiency is associated with immune dysfunction. The neonatal immune system is immature, and therefore an optimal neonatal zinc status may be important. The aim of this study was to investigate the possible association between neonatal whole blood (WB)-Zinc content and several immune markers. (2) Methods: In total, 398 healthy newborns (199 who later developed type 1 diabetes and 199 controls) from the Danish Newborn Screening Biobank had neonatal dried blood spots (NDBS) analyzed for WB-Zinc content and (i) cytokines: Interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-10, IL-12 (p70), interferon gamma, tumor necrosis factor alpha, and transforming growth factor beta; (ii) adipokines: leptin and adiponectin; (iii) other immune response proteins: C-reactive protein (CRP), and mannose-binding lectin (MBL), and soluble triggering receptors expressed on myeloid cells1 (sTREM-1). WB-Zinc content was determined using laser ablation inductively ...
https://research.regionh.dk/en/publications/perinatal-whole-blood-zinc-status-and-cytokines-adipokines-and-other-immune-response-proteins
DOAB: Directory of Open Access BooksDOAB: Directory of Open Access Books
Abstract. Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in ...
https://www.doabooks.org/doab?func=search&addFilter=utlic:%22CC%20by-nc-nd%22&template=&fromYear=&query=kw%3A%22liver%20steatosis%22&toYear=&uiLanguage=en
Duration of Lactation and Maternal Adipokines at 3 Years PostpartumDuration of Lactation and Maternal Adipokines at 3 Years Postpartum
Objective: Lactation has been associated with reduced maternal risk of type 2 diabetes, the metabolic syndrome, and cardiovascular disease. We examined the relationship between breastfeeding duration and maternal adipokines at 3 years postpartum. Research Design and Methods: We used linear regression to relate the duration of lactation to maternal leptin, adiponectin, ghrelin, and peptide YY (PYY) at 3 years postpartum among 570 participants with 3-year postpartum blood samples (178 fasting), prospectively collected lactation history, and no intervening pregnancy in Project Viva, a cohort study of mothers and children. Results: A total of 88% of mothers had initiated breastfeeding, 26% had breastfed \(\geq 12\) months, and 42% had exclusively breastfed for \(\geq 3\) months. In multivariate analyses, we found that duration of total breastfeeding was directly related to PYY and ghrelin, and exclusive breastfeeding duration was directly related to ghrelin (predicted mean for never exclusively ...
https://dash.harvard.edu/handle/1/10121112
Effects of short-term dry immersion on bone remodeling markers, insulin and adipokines - статья | ИСТИНА - Интеллектуальная...Effects of short-term dry immersion on bone remodeling markers, insulin and adipokines - статья | ИСТИНА - Интеллектуальная...
Аннотация: BackgroundDry immersion (DI), a ground-based model of microgravity previously used in Russia, has been recently implemented in France. The aim of this study was to analyze early events in a short-term DI model in which all conditions are met to investigate who is first challenged from osteo- or adipo-kines and to what extent they are associated to insulin-regulating hormones.MethodsTwelve healthy men were submitted to a 3-day DI. Fasting blood was collected during pre-immersion phase for the determination of the baseline data collection (BDC), daily during DI (DI24h, DI48H and DI72h), then after recovery (R+3h and R+24h). Markers of bone turnover, phosphocalcic metabolism, adipokines and associated factors were measured.ResultsBone resorption as assessed by tartrate-resistant acid phosphatase isoform 5b and N-terminal crosslinked telopeptide of type I collagen levels increased as early as DI24h. At the same time, total procollagen type I N- and C-terminal propeptides and ...
https://istina.ipmnet.ru/publications/article/302509448/
Valproic Acid and CEBPα-Mediated Regulation of Adipokine Gene Expression in Hypothalamic Neurons and 3T3-L1 Adipocytes -...Valproic Acid and CEBPα-Mediated Regulation of Adipokine Gene Expression in Hypothalamic Neurons and 3T3-L1 Adipocytes -...
|i|Background/Aims:|/i| Valproic acid (VPA) is the drug of choice for treating epilepsy, but has the unwanted effects of inducing weight gain and increasing the risk of developing insulin
https://www.karger.com/Article/Abstract/113927
Inflammation Matters » psoriasis
Cytokines are hormones that can modify cell behavior. Adipokines are cytokines produced by fat tissue that also function as hormones regulating many metabolic functions. Gerdes S, Rostami-Yazdi M and Mrowietz U. wrote a review article in Experimental Dermatology that discuses the possibility that adipokines contribute to the metabolic imbalances that make psoriasis patients more susceptible to cardiovascular disease. Read the summary to the paper at: Exp Dermatol. 2011 Feb;20(2):81-7. Adipokines and psoriasis.. ...
https://inflammes.com/inflammation/?tag=psoriasis-2
Parent-Offspring Transmission of Adipocytokine Levels and Their Associations with Metabolic TraitsParent-Offspring Transmission of Adipocytokine Levels and Their Associations with Metabolic Traits
Adipose tissue secreted cytokines (adipocytokines) have significant effects on the physiology and pathology of human metabolism relevant to diabetes and cardiovascular disease. We determined the relationship of the pattern of these circulating hormones with obesity-related phenotypes and whether such pattern is transmitted from parent to offspring. A combined total of 403 individuals from 156 consenting Saudi families divided into initial (119 families with 123 adults and 131 children) and replication (37 families with 58 adults and 91 children) cohorts were randomly selected from the RIYADH Cohort study. Anthropometrics were evaluated and metabolic measures such as fasting serum glucose, lipid profiles, insulin, leptin, adiponectin, resistin, tumor necrosis factor alpha (TNFα), activated plasminogen activator inhibitor 1 (aPAI1), high sensitivity C-reactive protein (hsCRP) and angiotensin II were also assessed. Parent-offspring regressions revealed that with the exception of hsCRP, all hormones
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018182
Plus it
The phenomenon of a discrepancy between glycated hemoglobin levels and other indicators of average glycemia may be due to many factors but can be measured as the glycation gap (GGap). This GGap is associated with differences in complications in patients with diabetes and may possibly be explained by dissimilarities in deglycation in turn leading to altered production of advanced glycation end products (AGEs). We hypothesized that variations in the level of the deglycating enzyme fructosamine-3-kinase (FN3K) might be associated with the GGap. We measured erythrocyte FN3K concentrations and enzyme activity in a population dichotomized for a large positive or negative GGap. FN3K protein was higher and we found a striking threefold greater activity (323%) at any given FN3K protein level in the erythrocytes of the negative-GGap group compared with the positive-GGap group. This was associated with lower AGE levels in the negative-GGap group (79%), lower proinflammatory adipokines ...
http://hw-f5-diabetes.highwire.org/content/67/1/131
Adipobiology of diabetes mellitus<...Adipobiology of diabetes mellitus<...
TY - JOUR. T1 - Adipobiology of diabetes mellitus. AU - Kim, M. J.. AU - Lee, E. Y.. AU - Lee, M. Y.. AU - Chung, C. H.. N1 - Copyright: Copyright 2009 Elsevier B.V., All rights reserved.. PY - 2007/4. Y1 - 2007/4. N2 - Accumulating basic and clinical studies indicate that adipose tissue cells (adipocytes, matrix cells, stromovascular cells and associated macrophages) synthesize and release multiple signaling proteins collectively termed adipokines. Adipokines regulate a broad spectrum of biological processes, with glucose and lipid metabolism being a key example. This defines a new field of study: adipobiology of type 2 diabetes mellitus. The importance of diabetes-related (diabetogenic) adipokines, with an emphasis on adiponectin, resistin, leptin, angiotensin 11, tumor necrosis factor-α, interleukin-6, and visfatin, is reviewed. Competing of pro- and anti-diabetogenic adipokine-mediated signals may pivotally be involved in the adipobiology of diabetes. This paradigm may reveal further new ...
https://yonsei.pure.elsevier.com/en/publications/adipobiology-of-diabetes-mellitus
Adipokines: therapeutic targets for metabolic syndrome. - PubMed - NCBIAdipokines: therapeutic targets for metabolic syndrome. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/16026271?dopt=Abstract
Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice - Dimensions
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https://app.dimensions.ai/details/publication/pub.1016114433
Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study - Central Connecticut State...Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study - Central Connecticut State...
Dossus, Laure ; Franceschi, Silvia ; Biessy, Carine ; Navionis, Anne-Sophie ; Travis, Ruth C ; Weiderpass, Elisabete ; Scalbert, Augustin ; Romieu, Isabelle ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Boutron-Ruault, Marie-Christine ; Bonnet, Fabrice ; Fournier, Agnès ; Fortner, Renée Turzanski ; Kaaks, Rudolf ; Aleksandrova, ...
https://cscu-ccsu-primo.hosted.exlibrisgroup.com/primo_library/libweb/action/display.do?tabs=viewOnlineTab&gathStatTab=true&ct=display&fn=search&doc=TN_swepuboai%3ADiVA.org%3Aumu-144783&indx=2&recIds=TN_swepuboai%3ADiVA.org%3Aumu-144783&recIdxs=1&elementId=1&renderMode=poppedOut&displayMode=full&frbrVersion=&frbrSourceidDisplay=swepub&vl
The Carb-Sane Asylum: Adipocyte Size & Adipokine SecretionThe Carb-Sane Asylum: Adipocyte Size & Adipokine Secretion
In contrast to the published studies, which demonstrated associations between average adipocyte size and serum levels or secretion, our study is unique because it investigated the secretory capacity of adipocyte fractions from the same individual separated by cell size. The results obtained by the technique clearly suggest that only the very large adipocytes are dysregulated. Adipocyte hypertrophy appears to cause a differentially impaired secretion between pro- and antiinflammatory adipokines shifting the immunological balance toward the expression of proinflammatory proteins. Thisabnormal function of adipocytes may play an important role in the development of a chronic low-grade proinflammatory state in obesity, which is considered to build the common soil for the development of insulin resistance, type 2 diabetes, and atherosclerosis (5, 68 ...
http://carbsanity.blogspot.com/2010/10/adipocyte-size-adipokine-secretion.html
Perivascular adipose tissue and coronary atherosclerosis - Oxford Cardiovascular Science
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https://www.cardioscience.ox.ac.uk/publications/843977/
IntechOpen Open Access Publisher - Open Science Open Minds | IntechOpenIntechOpen Open Access Publisher - Open Science Open Minds | IntechOpen
Immunometabolism in Obesity. By Efrain Chavarria-Avila, Rosa-Elena Navarro-Hernández, Milton- Omar Guzmán-Ornelas, Fernanda-Isadora Corona-Meraz, Sandra- Luz Ruíz-Quezada and Mónica Vázquez-Del Mercado. Immunometabolism is a current issue that has shown relevance in recent years, because the way we understand the adipose tissue has shifted from simply being a site of energy storage to a very active endocrine organ, which dysregulation has a major impact on other systems, especially on the immune one. Understanding the molecular basis of the regulation of adipose tissue is essential to look for alternatives in the treatment and prognosis of obesity in future generations. In this regard, it is described that the immune system has great importance in physiological processes of adipose tissue and vice versa. The main objective of this chapter is to describe the relationship between the immune system and metabolism, emphasizing dysregulation when obesity is present. Upon completion of this ...
https://www.intechopen.com/profiles/191565/rosa-elena-navarro-hernandez
Ijfas vol2
behaves as a dynamic endocrine organ4. It also plays an important role in energy expenditure, both as depot for energy- Many chronic diseases like type 2 diabetes and its rich triglycerides and as a source for metabolic hormones as complications may be preventable by avoiding factors that well5,6. Adipocytes produce a large number of so-called trigger the disease process (primary prevention) or by use of adipokines, such as leptin, adiponectin, interleukin (IL)-1b, IL- therapies that modulate the disease process before the onset of 6 and tumor necrosis factor-alpha (TNF-a). Some of these clinical symptoms (secondary prevention). Accurate prediction molecules affect energy metabolism and insulin sensitivity in and identification using biomarkers will be useful for disease other tissues such as muscle and liver7. During obesity, lipid prevention and initiation of proactive therapies to those storage in adipocytes is increased, which triggers the release of individuals who are most likely to ...
http://onlinepdfcatalog.com/b/bma.org.in1.html
Observational Study of Early Metabolic and Vascular Changes in Obesity - Full Text View - ClinicalTrials.govObservational Study of Early Metabolic and Vascular Changes in Obesity - Full Text View - ClinicalTrials.gov
Obesity is dramatically increasing in countries with so called western Lifestyle, whereby juveniles are affected in particular. Atherosclerosis, a major consequence of obesity, starts early in life and results in cardiovascular disease and stroke, the main causes of mortality in industrialized countries. STYJOBS / EDECTA is a prospective, observational study to improve the understanding of atherosclerosis and metabolic changes in obesity by investigation of the non-biased early phase.. We aim. To identify individual metabolic high risk patterns in obesity by linking lab parameters (adipokines, immune-inflammatory mediators, oxidative stress biomarkers, lipoproteins, molecular genetics, epigenetics), individual adipose tissue topography, early vascular damage, life style habits, and clinical data.. The STYJOBS/EDECTA-Database comprehends currently data from 1325 subjects.For each proband 282 variables are available (Clinical, anthropometric, carotis IMT, 82; Laboratory/Biomarkers, 100; ...
https://clinicaltrials.gov/ct2/show/NCT00482924?recr=Open&cond=%22Obesity%22&rank=8
Loss of Krüppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12...Loss of Krüppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12...
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http://diabetes.diabetesjournals.org/content/62/8/2728.full
TamPub - Selaus tekijän mukaan Leppänen, Tiina
Background and Objective. The role of adipokines in regulation of immune responses has been recognized, but very little is known about their impact on multiple sclerosis (MS). In this study, we analysed whether the major ...
http://tampub.uta.fi/handle/10024/59337/browse?value=Lepp%C3%A4nen%2C+Tiina&type=author
Paneristi Public Forum: *** SIHH 2012 | RADIOMIR CALIFORNIA 3 DAYS - 47 MM - PAM448 SPECIAL EDITION ***Paneristi Public Forum: *** SIHH 2012 | RADIOMIR CALIFORNIA 3 DAYS - 47 MM - PAM448 SPECIAL EDITION ***
So far Im thrilled about the fact that the only one I would really like- is the cermaic Tourboullin in 48mm.....and Im not going to sell organs so im good so far ...
http://www.network54.com/Forum/353391/thread/1326703448?orderid=820780199&moveto=prevtopic
CTRP7抗体|Abcam中国|Anti-CTRP7抗体(ab115449)CTRP7抗体|Abcam中国|Anti-CTRP7抗体(ab115449)
CTRP7兔多克隆抗体(ab115449)可与人样本反应并经WB, IHC, ICC实验严格验证。中国75%以上现货，所有产品均提供质保服务，可通过电话、电邮或微信获得本地专属技术支持。
http://www.abcam.cn/ctrp7-antibody-ab115449.html
AdipokineAdipokine
The first adipokine to be discovered was leptin in 1994. Since that time, hundreds of adipokines have been discovered. Members ... Adipokines at the US National Library of Medicine Medical Subject Headings (MeSH) (Articles with short description, Short ... The adipokines, or adipocytokines (Greek adipo-, fat; cytos-, cell; and -kinos, movement) are cytokines (cell signaling ... Conde J, Scotece M, Gómez R, López V, Gómez-Reino JJ, Lago F, Gualillo O (2011). "Adipokines: BioFactors from white adipose ...
https://en.wikipedia.org/wiki/Adipokine
SERPIN A12SERPIN A12
... is a protease inhibitor with an approximate weight of 47 kDa and is a member of the adipokine family of cytokines ... "Adipokines". US National Library of Medicine Medical Subject Headings (MeSH). January 1, 2008. Retrieved November 1, 2020. ... Kyrou I, Mattu HS, Chatha K, Randeva HS (2017). "Fat Hormones, Adipokines". Endocrinology of the Heart in Health and Disease. ...
https://en.wikipedia.org/wiki/SERPIN_A12
CCL7CCL7
Ouchi N, Parker JL, Lugus JJ, Walsh K (February 2011). "Adipokines in inflammation and metabolic disease". Nature Reviews. ...
https://en.wikipedia.org/wiki/CCL7
LeptinLeptin
... including the cell signalling proteins known as adipokines. Certain adipokines can be considered as hormones, as they regulate ... March 2014). "Adipokines as drug targets in joint and bone disease". Drug Discovery Today. 19 (3): 241-258. doi:10.1016/j. ... Conde J, Scotece M, Gómez R, López V, Gómez-Reino JJ, Lago F, Gualillo O (2011). "Adipokines: biofactors from white adipose ... Leptin was the first fat cell-derived hormone (adipokine) to be discovered. Subsequent studies in 1995 confirmed that the db ...
https://en.wikipedia.org/wiki/Leptin
Christos Socrates MantzorosChristos Socrates Mantzoros
Ko, Byung-Joon; Park, Kyung Hee; Mantzoros, Christos S (2014). "Diet patterns, adipokines, and metabolism: Where are we and ... Polyzos, Stergios A; Kountouras, Jannis; Mantzoros, Christos S (2016). "Adipokines in nonalcoholic fatty liver disease". ... Boutari, Chrysoula; Perakakis, Nikolaos; Mantzoros, Christos S (2018). "Association of Adipokines with Development and ... myokines and adipokines (i.e. leptin and adiponectin) in human physiology and pathophysiology. Leptin has subsequently been ...
https://en.wikipedia.org/wiki/Christos_Socrates_Mantzoros
Obesity-associated morbidityObesity-associated morbidity
The result is reduction of the testis' production of testosterone and a further increase in adipokine levels. This then feeds ... Peterlin BL, Sacco S, Bernecker C, Scher AI (April 2016). "Adipokines and Migraine: A Systematic Review". Headache. 56 (4): 622 ... In males, obesity and metabolic syndrome both increase estrogen and adipokine production. This reduces gonadotropin-releasing ...
https://en.wikipedia.org/wiki/Obesity-associated_morbidity
HepatokineHepatokine
Adipokines Myokines Meex, Ruth C. R.; Watt, Matthew J. (September 2017). "Hepatokines: linking nonalcoholic fatty liver disease ...
https://en.wikipedia.org/wiki/Hepatokine
Obesity and fertilityObesity and fertility
Adipocytes (fat cells) secrete proteins and signaling molecules known as adipokines. Certain adipokines have been implicated in ... Pro-inflammatory adipokines secreted by adipocytes have been demonstrated to stimulate fatty acid accumulation. Fatty acids are ... Leptin is a satiety adipokine released from adipocytes. Normally, leptin interacts with leptin receptors (LEPRs) in the brain ... Mitchell M, Armstrong DT, Robker RL, Norman RJ (November 2005). "Adipokines: implications for female fertility and obesity". ...
https://en.wikipedia.org/wiki/Obesity_and_fertility
Hepatic portal systemHepatic portal system
Dhawan D, Sharma S (2020). "Abdominal Obesity, Adipokines and Non-communicable Diseases". The Journal of Steroid Biochemistry ...
https://en.wikipedia.org/wiki/Hepatic_portal_system
Adipose tissueAdipose tissue
Ohta H, Itoh N (2014). "Roles of FGFs as Adipokines in Adipose Tissue Development, Remodeling, and Metabolism". Frontiers in ... Perivascular adipose tissue releases adipokines such as adiponectin that affect the contractile function of the vessels that ... Mancuso P (May 2016). "The role of adipokines in chronic inflammation". ImmunoTargets and Therapy. 5 (2016): 47-56. doi:10.2147 ... Adipose Tissue and Adipokines in Health and Disease. Nutrition and Health. Humana Press. pp. 221-236. doi:10.1007/978-1-59745- ...
https://en.wikipedia.org/wiki/Adipose_tissue
C-reactive proteinC-reactive protein
Lau DC, Dhillon B, Yan H, Szmitko PE, Verma S (May 2005). "Adipokines: molecular links between obesity and atheroslcerosis". ...
https://en.wikipedia.org/wiki/C-reactive_protein
FAM132AFAM132A
Adipolin is an adipokine. GRCh38: Ensembl release 89: ENSG00000184163 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... a novel adipokine in human and murine ATDC-5 chondrocyte cell line". Ann. Rheum. Dis. 72 (1): 140-2. doi:10.1136/annrheumdis- ... "Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism". J. Biol. Chem. 286 (40): 34552-8. ...
https://en.wikipedia.org/wiki/FAM132A
Pathophysiology of obesityPathophysiology of obesity
The adipokines are mediators produced by adipose tissue; their action is thought to modify many obesity-related diseases. ...
https://en.wikipedia.org/wiki/Pathophysiology_of_obesity
Drifty gene hypothesisDrifty gene hypothesis
Adipose Tissue and Adipokines in Health and Disease. New York: Humana Press: 193-208. Speakman, John R (July 11, 2007). " ...
https://en.wikipedia.org/wiki/Drifty_gene_hypothesis
ResistinResistin
This adipokine is associated with markers of inflammation in seminal plasma and the concentrations of seminal resistin ... Elfassy Y, Bastard JP, McAvoy C, Fellahi S, Dupont J, Levy R (2018). "Adipokines in Semen: Physiopathology and Effects on ... Malyszko J, Malyszko JS, Pawlak K, Mysliwiec M (December 2006). "Resistin, a new adipokine, is related to inflammation and ... an adipokine-mediated process?". Diabetes. 51 (10): 2951-8. doi:10.2337/diabetes.51.10.2951. PMID 12351432. Levy JR, Davenport ...
https://en.wikipedia.org/wiki/Resistin
George ChaldakovGeorge Chaldakov
Chaldakov GN, Stankulov IS, Hristova MG, Ghenev PI (2003). "Adipobiology of disease: adipokines and adipokine-targeted ... Conceptualize the protein secretory products of adipose tissue cells as adipokines, also focusing on perivascular adipose ... adipokines, cytokines). In 1991, Chaldakov became founder and chief editor of Biomedical Reviews, An International Journal of ...
https://en.wikipedia.org/wiki/George_Chaldakov
Nicotinamide phosphoribosyltransferaseNicotinamide phosphoribosyltransferase
Bełtowski J (June 2006). "Apelin and visfatin: unique "beneficial" adipokines upregulated in obesity?". Medical Science Monitor ...
https://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase
HaptoglobinHaptoglobin
"Entrez Gene: HP". Trayhurn P, Wood IS (September 2004). "Adipokines: inflammation and the pleiotropic role of white adipose ... "Bovine haptoglobin as an adipokine: Serum concentrations and tissue expression in dairy cows receiving a conjugated linoleic ...
https://en.wikipedia.org/wiki/Haptoglobin
N-AcylethanolamineN-Acylethanolamine
Trayhurn, Paul; Bing, Chen; Wood, I. Stuart (2006-07-01). "Adipose Tissue and Adipokines-Energy Regulation from the Human ...
https://en.wikipedia.org/wiki/N-Acylethanolamine
List of human endocrine organs and actionsList of human endocrine organs and actions
Signalling molecules released by adipose tissue are referred to as adipokines. Vander A (2008). Vander's Human Physiology: the ...
https://en.wikipedia.org/wiki/List_of_human_endocrine_organs_and_actions
ObesityObesity
Theodore Mazzone; Giamila Fantuzzi (2006). Adipose Tissue And Adipokines in Health And Disease (Nutrition and Health). Totowa, ...
https://en.wikipedia.org/wiki/Obesity
Equine metabolic syndromeEquine metabolic syndrome
It is possible adipokines and cytokines made in adipose tissue down-regulate insulin pathways. It is also possible that IR ... The cells of adipose (fat) tissue synthesizes hormones known as adipokines. In humans, dysfunction of adipose tissue, even in ... leading to the production of more adipokines and perpetuation of the cycle, and a constant low-level, pro-inflammatory state. ...
https://en.wikipedia.org/wiki/Equine_metabolic_syndrome
EDIL3EDIL3
... a novel adipokine in the regulation of angiogenesis". J. Clin. Endocrinol. Metab. 95 (5): 2476-85. doi:10.1210/jc.2010-0042. ...
https://en.wikipedia.org/wiki/EDIL3
TRHDETRHDE
... a novel adipokine in the regulation of angiogenesis". The Journal of Clinical Endocrinology and Metabolism. 95 (5): 2476-85. ...
https://en.wikipedia.org/wiki/TRHDE
B-cell activating factorB-cell activating factor
Kim YH, Choi BH, Cheon HG, Do MS (March 2009). "B cell activation factor (BAFF) is a novel adipokine that links obesity and ... "B cell-activating factor controls the production of adipokines and induces insulin resistance". Obesity. 19 (10): 1915-22. doi: ...
https://en.wikipedia.org/wiki/B-cell_activating_factor
ChemerinChemerin
Roh SG, Song SH, Choi KC, Katoh K, Wittamer V, Parmentier M, Sasaki S (Sep 2007). "Chemerin--a new adipokine that modulates ... Because of its role in adipocyte differentiation and glucose uptake, chemerin is classified as an adipokine. Chemerin has been ... a novel adipokine that regulates adipogenesis and adipocyte metabolism". J. Biol. Chem. 282 (38): 28175-88. doi:10.1074/jbc. ... "Chemerin is a novel adipokine associated with obesity and metabolic syndrome". Endocrinology. 148 (10): 4687-94. doi:10.1210/en ...
https://en.wikipedia.org/wiki/Chemerin
CMKLR1CMKLR1
As an adipokine receptor it has a role in adipogenesis and adipocyte maturation. It seems also to have a role in peripheral ... Chemokine receptor-like 1 is a G protein-coupled receptor for the chemoattractant adipokine chemerin and the omega-3 fatty acid ... Darios ES, Winner BM, Charvat T, Krasinksi A, Punna S, Watts SW (August 2016). "The adipokine chemerin amplifies electrical ... "Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice". Journal of Bone and Mineral Research. 32 (5 ...
https://en.wikipedia.org/wiki/CMKLR1
ApelinApelin
... a newly identified adipokine up-regulated by insulin and obesity". Endocrinology. 146 (4): 1764-71. doi:10.1210/en.2004-1427. ...
https://en.wikipedia.org/wiki/Apelin
Undurti Narasimha DasUndurti Narasimha Das
"Effects of bariatric surgery on adipokine-induced inflammation and insulin resistance". Frontiers in Endocrinology. 4: 69. doi: ...
https://en.wikipedia.org/wiki/Undurti_Narasimha_Das
AdiponectinAdiponectin
January 2014). "Serum adipokine levels in rheumatoid arthritis patients and their contributions to the resistance to treatment ... Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein hormone and adipokine, which is involved in ... Hara K, Yamauchi T, Kadowaki T (April 2005). "Adiponectin: an adipokine linking adipocytes and type 2 diabetes in humans". ...
https://en.wikipedia.org/wiki/Adiponectin
Prediagnostic circulating adipokine concentrations and risk of renal cell carcinoma in male smokers. • Arctic Health
Adipokines - blood Carcinoma, Renal Cell - blood - epidemiology Case-Control Studies Finland Humans Kidney Neoplasms - blood - ... Prediagnostic circulating adipokine concentrations and risk of renal cell carcinoma in male smokers. https://arctichealth.org/ ...
https://arctichealth.org/en/permalink/ahliterature120078
Chemerin--a new adipokine that modulates adipogenesis via its own receptorChemerin--a new adipokine that modulates adipogenesis via its own receptor
... Biochem Biophys Res Commun. 2007 Nov 3;362(4):1013-8 ... Thus, the adipokine chemerin likely regulates adipocyte function by autocrine/paracrine mechanisms. ...
https://pubmed.ncbi.nlm.nih.gov/17767914/?dopt=Abstract
Fat Hormones, Adipokines<...Fat Hormones, Adipokines<...
... and hormones into the systemic circulation that are collectively described as adipokines. Adipokines exert pleiotropic effects ... and hormones into the systemic circulation that are collectively described as adipokines. Adipokines exert pleiotropic effects ... and hormones into the systemic circulation that are collectively described as adipokines. Adipokines exert pleiotropic effects ... and hormones into the systemic circulation that are collectively described as adipokines. Adipokines exert pleiotropic effects ...
https://research.aston.ac.uk/en/publications/fat-hormones-adipokines
British Library EThOS: Investigating the impact of c-Cbl deficiency in adipose tissue : its role in insulin sensitivity and...British Library EThOS: Investigating the impact of c-Cbl deficiency in adipose tissue : its role in insulin sensitivity and...
The adipokine profile was altered in WAT of female Cbl -/- mice: leptin and RBP4 were increased, whereas adiponectin was ... However, the role of c-Cbl in adipokine expression is currently unknown. c-Cbl knockout (Cbl -/- ) mice were previously found ... Investigating the impact of c-Cbl deficiency in adipose tissue : its role in insulin sensitivity and adipokine production ... specifically in glucose and lipid metabolism and adipokine production. c-Cbl knockout mice exhibited no changes in overall food ...
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.762827
In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children<...In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children<...
In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. In: ... In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. / ... These data suggest that in the absence of weight loss, exercise training alone does not improve the adipokine profile or levels ... In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. ...
https://experts.umn.edu/en/publications/in-the-absence-of-weight-loss-exercise-training-does-not-improve-
RePub, Erasmus University Repository: First trimester secreted Frizzled-Related Protein 4 and other adipokine serum...RePub, Erasmus University Repository: First trimester secreted Frizzled-Related Protein 4 and other adipokine serum...
First trimester secreted Frizzled-Related Protein 4 and other adipokine serum concentrations in women developing gestational ... First trimester secreted Frizzled-Related Protein 4 and other adipokine serum concentrations in women developing gestational ...
https://repub.eur.nl/pub/131686
Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic individuals: a randomized controlled trial | Nutrition ...Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic individuals: a randomized controlled trial | Nutrition ...
Adipokines have been demonstrated to be vital targets of metabolic diseases. The hypothesis that adipokines mediate the ... Our study shows that CoQ10 ameliorates glucolipid profile and adipokines dysfunction in dyslipidemic patients in 24 weeks ... Adipokines have been demonstrated to be vital targets of metabolic diseases. The hypothesis that adipokines mediate the ... Mediating effects of adipokines. To further investigate the possible mechanism that adipokines mediated the relationship ...
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-022-00649-5
Serum adipokine and inflammatory markers before and after liver transplantation in recipients with major cardiovascular events<...
Watt, K. D., Fan, C., Therneau, T., Heimbach, J. K., Seaberg, E. C., & Charlton, M. R. (2014). Serum adipokine and inflammatory ... Serum adipokine and inflammatory markers before and after liver transplantation in recipients with major cardiovascular events. ... In conclusion, pre- and post-LT changes in serum adipokine and inflammatory markers may be signals of an increased risk of CV ... Serum adipokine and inflammatory markers before and after liver transplantation in recipients with major cardiovascular events ...
https://mayoclinic.pure.elsevier.com/en/publications/serum-adipokine-and-inflammatory-markers-before-and-after-liver-t
Vitamin D insufficiency is associated with inflammation and deregulation of adipokines in patients with metabolic syndrome |...Vitamin D insufficiency is associated with inflammation and deregulation of adipokines in patients with metabolic syndrome |...
Therefore, we assessed whether serum vitamin D status is associated with serum levels of adipokines and inflammatory markers in ... Besides, inflammation and deregulation of adipokines secretion have been recognized as pivotal factors that contribute to the ... findings indicated that vitamin D insufficiency in MetS patients is associated with increased inflammation and serum adipokine ... Table 2 Serum concentrations of adipokines and inflammatory markers in the participants by the vitamin D statusa. Full size ...
https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-022-01141-0
Adipokines and the intervertebral disc: does a biochemical link exist between obesity and back pain? - Nuffield Department of...
Adipokines and the intervertebral disc: does a biochemical link exist between obesity and back pain? ... Adipokines and the intervertebral disc: does a biochemical link exist between obesity and back pain? ...
https://www.ndorms.ox.ac.uk/publications/468936
adipokines | aliquotthesciencespotadipokines | aliquotthesciencespot
Posts about adipokines written by Dr. Stacia Nicholson, PhD ... adipokines Fat is Alive & Talks to Your Brain. May 13, 2018. ...
https://aliquotthesciencespot.com/tag/adipokines/
Adipokines as possible new predictors of cardiovascular diseases: a case control study.
... L. Pala;M. Monami;S. Ciani;DICEMBRINI ... Adipokines as possible new predictors of cardiovascular diseases: a case control study / L. Pala;M. Monami;S. Ciani;I. ...
https://flore.unifi.it/handle/2158/619406
IMSEAR at SEARO: Role of Adipokines in Development of Metabolic Syndrome
Role of Adipokines in Development of Metabolic Syndrome. Annals of the National Academy of Medical Sciences (India). 2018 Oct; ... Insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Adipokines gene polymorphisms were studied by ... Visceral adipose tissue releases a variety of adipokines which together determine a comprehensive cardiometabolic risk profile ... Conclusively changes in fat distribution modulate the secretion profile of adipokines, therefore elevated circulating leptin, ...
https://imsear.searo.who.int/handle/123456789/189723
Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Womens Health Across...Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across...
Adipokines Adiponectin Article Bayes Theorem Cross-Sectional Studies Female Humans Leptin Middle Aged Midlife Women Parabens ... Urinary Metals and Adipokines in Midlife Women: The Study of Womens Health Across the Nation (SWAN) Cite ... Adipokines, cytokines secreted by adipose tissue, may contribute to obesity-related metabolic disease. The role of ... Serum adipokines included adiponectin, high molecular weight (HMW)-adiponectin, leptin, soluble leptin receptor (sOB-R). Linear ...
https://stacks.cdc.gov/view/cdc/124073
Adipose Tissue | Diabetes | American Diabetes AssociationAdipose Tissue | Diabetes | American Diabetes Association
Additional adipokines and the secretory pathway of adipocytes.. Adiponectin is not the only adipokine that attracted our ... An adipokine that has been the focus of a large number of studies over the last couple of years is the protein adiponectin. ... Using adipokines as one of the major communication tools, adipocytes affect a large number of other tissues, such as the liver ... They transcriptionally induce adipokines, such as adiponectin. They also regulate part of the machinery required for the ...
https://diabetesjournals.org/diabetes/article/55/6/1537/15609/Adipose-TissueFrom-Lipid-Storage-Compartment-to
Adipokines and coronary vasomotor dysfunction<...
Particular emphasis is placed on the action of adipokines in the coronary circulation - especially effects of adipokines on ... Particular emphasis is placed on the action of adipokines in the coronary circulation - especially effects of adipokines on ... Particular emphasis is placed on the action of adipokines in the coronary circulation - especially effects of adipokines on ... Particular emphasis is placed on the action of adipokines in the coronary circulation - especially effects of adipokines on ...
https://experts.unthsc.edu/en/publications/adipokines-and-coronary-vasomotor-dysfunction
Hypoadiponectinemia: A Link between Visceral Obesity and Metabolic SyndromeHypoadiponectinemia: A Link between Visceral Obesity and Metabolic Syndrome
These bioactive substances are classified as "adipokines or adipocytokines" and are subdivided into adipokines adipose tissue ... H. Zhang, J. Cui, and C. Zhang, "Emerging role of adipokines as mediators in atherosclerosis," World Journal of Cardiology, vol ... 2. The Adipokines. Adipose tissue participates in the regulation of a variety of homeostatic processes as an endocrine organ ... Adipokines and adipocytokines have a role both in the regulation of the glucose and lipid metabolism, in the control of ...
https://www.hindawi.com/journals/jnme/2012/175245/
Solution structure of CXCL5 - A novel chemokine and adipokine implicated in inflammation and obesity<...Solution structure of CXCL5 - A novel chemokine and adipokine implicated in inflammation and obesity<...
Solution structure of CXCL5 - A novel chemokine and adipokine implicated in inflammation and obesity. PloS one. 2014 Apr 2;9(4 ... Sepuru, K. M., Poluri, K. M., & Rajarathnam, K. (2014). Solution structure of CXCL5 - A novel chemokine and adipokine ... Solution structure of CXCL5 - A novel chemokine and adipokine implicated in inflammation and obesity. In: PloS one. 2014 ; Vol ... Sepuru, KM, Poluri, KM & Rajarathnam, K 2014, Solution structure of CXCL5 - A novel chemokine and adipokine implicated in ...
https://researchexperts.utmb.edu/en/publications/solution-structure-of-cxcl5-a-novel-chemokine-and-adipokine-impli
LEGENDplex Human Adipokine Panel Detection AntibodiesLEGENDplex Human Adipokine Panel Detection Antibodies
Human Adipokine Panel Detection Antibodies product is intended for use with the Mix and Match Human Adipokine Panel of products ... Human Adipokine Panel Detection Antibodies - The LEGENDplex™ ... The LEGENDplex™ Human Adipokine Panel Detection Antibodies product is intended for use with the Mix and Match Human Adipokine ... 740210 (LEGENDplex™ Human Adipokine Panel Standard). 740374 (LEGENDplex™ Buffer Set C). 740197 (LEGENDplex™ Human Adiponectin ...
https://production-dynamicweb.biolegend.com/en-us/products/legendplex-human-adipokine-panel-detection-antibodies-11792
Osteoarthritis Workup: Approach Considerations, Plain Radiography, MRI, CT, and UltrasonographyOsteoarthritis Workup: Approach Considerations, Plain Radiography, MRI, CT, and Ultrasonography
Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation ...
https://www.medscape.com/answers/330487-44932/what-is-the-role-of-bone-scanning-in-the-diagnosis-of-osteoarthritis-oa
Register - Enzo Life SciencesRegister - Enzo Life Sciences
Diabetes/Obesity/Adipokines. DNA Damage. DNA Regulation / Transcription. DNA/Protein Labeling. Drug Discovery. ...
https://www.enzolifesciences.com/my-account/register/regback/https%253A%252F%252Fwww.enzolifesciences.com%252Fproduct-listing%252F%253FText%253DResveratrol/
Asthma control, adiposity, and adipokines among inner-city adolescents<...
keywords = "adipokines, adiponectin, asthma, leptin, Obesity",. author = "Meyer Kattan and Rajesh Kumar and Bloomberg, {Gordon ... Asthma control, adiposity, and adipokines among inner-city adolescents. In: The Journal of Allergy and Clinical Immunology. ... Asthma control, adiposity, and adipokines among inner-city adolescents. The Journal of Allergy and Clinical Immunology. 2010 ... Asthma control, adiposity, and adipokines among inner-city adolescents. Meyer Kattan, Rajesh Kumar, Gordon R. Bloomberg, Herman ...
https://jhu.pure.elsevier.com/en/publications/asthma-control-adiposity-and-adipokines-among-inner-city-adolesce-4
The Adipokine-Cardiovascular-Lifestyle Network: Translation to Clinical PracticeThe Adipokine-Cardiovascular-Lifestyle Network: Translation to Clinical Practice
Adipokines are peptides, secreted by adipocytes and other cell types with targets in other tissues, participating in a complex ... This review describes recent information about adipokine effects on the CV system. Rather than simply providing a listing of ... Various relationships and emergent processes in the adipokine-CV system network are discussed, with the most significant ... As more translatable information about the larger adipokine-CV-lifestyle network is acquired from laboratory and clinical ...
http://scholars.uab.edu/display/pub940349
Osteoarthritis Treatment & Management: Approach Considerations, Pharmacologic Treatment, Lifestyle Modification, Physical...Osteoarthritis Treatment & Management: Approach Considerations, Pharmacologic Treatment, Lifestyle Modification, Physical...
118] In addition, weight loss lowers levels of the inflammatory cytokines and adipokines that may play a role in cartilage ... Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation ...
http://emedicine.medscape.com/article/330487-treatment
Adipokines and osteoarthritis: Novel molecules involved in the pathogenesis and progression of diseaseAdipokines and osteoarthritis: Novel molecules involved in the pathogenesis and progression of disease
... Conde Aranda, Javier; ... In this paper, we review the role of adipokines and highlight the cellular and molecular mechanisms at play in osteoarthritis ... We also emphasize how defining the role of adipokines has broadned our understanding of the diversity of factors involved in ... called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. ...
https://runa.sergas.gal/xmlui/handle/20.500.11940/5648
Science Clips - Volume 13, Issue 21, June 22, 2021Science Clips - Volume 13, Issue 21, June 22, 2021
Adipokines including leptin, soluble leptin receptor (sOB-R), free leptin index (FLI, the ratio of leptin to sOB-R), total and ... However, the effects of PFAS on adipokines are not well understood. OBJECTIVE: We determined if serum PFAS concentrations were ... Understanding associations between PFAS and adipokines may help elucidate whether PFAS can influence obesity and metabolic ... Associations of perfluoroalkyl and polyfluoroalkyl substances (PFAS) and PFAS mixtures with adipokines in midlife womenexternal ...
https://www.cdc.gov/library/sciclips/issues/v13issue21.html
Leptin in the interplay of inflammation, metabolism and immune system disorders | Nature Reviews RheumatologyLeptin in the interplay of inflammation, metabolism and immune system disorders | Nature Reviews Rheumatology
... the most relevant factors secreted by adipose tissue and the forerunner of a class of molecules collectively called adipokines ... Dis. 70, 551-559 (2011). This article described for the first time the expression of a novel network of adipokines locally ... Basic aspects of adipokines in bone metabolism. Clin. Rev. Bone Miner. Metab. 13, 11-19 (2015). ... Systemic versus local adipokine expression differs in a combined obesity and osteoarthritis mouse model *Marie-Lisa Hülser ...
https://www.nature.com/articles/nrrheum.2016.209?error=cookies_not_supported&code=22e9b86f-650f-429a-a7ef-b50edcb66362
NIOSHTIC-2 Search Results - Full View
... were fit to identify metals associated with adipokines and to compute estimated percent changes in adipokines for one standard ... Serum adipokines including high molecular weight (HMW)-adiponectin, leptin, and soluble leptin receptor (sOB-R) were measured ... Urinary metals and adipokines in midlife women: the Study of Womens Health Across the Nation (SWAN). ... Background: Information on the associations between metal exposures and adipokines in human populations is limited and results ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=cobalt&f1=%2A&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=1&RecNo=10&View=f&
Search Results | Clinical Science | Portland PressSearch Results | Clinical Science | Portland Press
as an endocrine organ, secreting soluble factors termed adipocytokines or adipokines. These adipokines play crucial roles in ... change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune ... inflammatory adipokines in PE and healthy pregnancy. Subcutaneous and visceral adipose tissue biopsies were collected from ... with resistin, an adipokine that was shown to increase the permeability of endothelial cells in vitro , shedding light on the ...
https://portlandpress.com/clinsci/search-results?qb=%7B%22Keywords1%22:%22adipokines%22%7D
Osteoarthritis Guidelines: Guidelines Summary, Hand Osteoarthritis, Knee OsteoarthritisOsteoarthritis Guidelines: Guidelines Summary, Hand Osteoarthritis, Knee Osteoarthritis
Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation ...
https://emedicine.medscape.com/article/330487-guidelines
AdiponectinAdiposeObesityOxidative stressAdipocytesConcentrationsInflammationResistinCytokinesBiomarkersChemerinAdipocyte-derivedMarkersObeseCoronaryAnti-inflammatorySerum levelsAdiposityHormones releasedDysfunctionCardiovascular diseasesMetabolismMetSOsteoarthritisLevelsProcessesRoleInflammatory stateEffectsUrinaryPregnancy
Adiponectin13
  • The adipokine profile was altered in WAT of female Cbl -/- mice: leptin and RBP4 were increased, whereas adiponectin was reduced. (bl.uk)
  • Some adipokines such as adiponectin can modulate transcription factor such as peroxisome proliferator- activated receptors (PPARs) that regulate gene expression involved in lipid metabolism in multiple tissues [ 9 ]. (biomedcentral.com)
  • Adipokines' gene polymorphisms were studied by polymerase chain reaction and mRNA expression of leptin, adiponectin, resistin, and interleukin-6 (IL-6). (who.int)
  • Conclusively changes in fat distribution modulate the secretion profile of adipokines, therefore elevated circulating leptin, IL-6, TNF-α, ASP, resistin, and low adiponectin may serve as surrogate markers for metabolic syndrome and related morbidities in women with central obesity. (who.int)
  • Serum adipokines including high molecular weight (HMW)-adiponectin, leptin, and soluble leptin receptor (sOB-R) were measured at the follow-up visit (2002-2003). (cdc.gov)
  • Conclusions: Our findings suggest that molybdenum was associated with favorable profiles of HMW-adiponectin, leptin, and sOB-R. Exposures to cadmium, cesium, and lead were associated with adverse adipokine profiles. (cdc.gov)
  • The effect of leptin and adiponectin, which are two adipokines with opposing effects, has been explored in this study. (openrepository.com)
  • In order to explore the role of adipokines in cardiovascular diseases, EAHY human endothelial cells were cultured and treated with various concentrations of adiponectin and leptin both individually and in combinations and cells collected and mRNA extracted in order to carry out a reverse transcription PCR for the expression of angiogenic (TIMP2, TIMP3 and MMP2) genes and atherosclerotic (LPA and LPL) genes. (openrepository.com)
  • The adipokines, leptin and adiponectin, have a prominent role in the pathogenesis of coronary artery disease (CAD). (ac.ir)
  • Considering the presence of significant association between leptin and MPO, as well as adiponectin and MPO in patients with CAD, it may be inferred that the contribution of the adipokines in the pathogenesis of CAD may be, in part, through affecting the MPO concentration. (ac.ir)
  • Adipokines, including leptin and adiponectin, may be involved in the pathogenesis of CKD. (medpagetoday.com)
  • There is an increasing recognition that adipose tissue is an endocrine organ secreting a number of biologically active adipokines such as leptin, adiponectin, and tumor necrosis factor-α. (docksci.com)
  • Among various adipocyte-derived adipokines, adiponectin has attracted considerable attention due to its role in cardiovascular disorders. (docksci.com)
Adipose12
  • Adipose tissue functions as a dynamic endocrine organ secreting multiple proteins, factors, and hormones into the systemic circulation that are collectively described as adipokines. (aston.ac.uk)
  • Expanding adipose tissue in obesity undergoes a change in the adipokine secretion profile characterized by an increase of proinflammatory adipokines and suppression of anti-inflammatory adipokines increasing proinflammatory pathways within adipose tissue depots and creating an adverse circulating adipokine profile, resulting in a chronic, low-grade, systemic inflammatory state. (aston.ac.uk)
  • This chapter presents a brief overview of the nature of adipose tissue in obesity and focuses on selected adipokines that have direct and indirect effects on the heart and cardiovascular system. (aston.ac.uk)
  • In this study, the role of c-Cbl signalling was examined in white adipose tissue (WAT) of a Cbl -/- mouse model, specifically in glucose and lipid metabolism and adipokine production. (bl.uk)
  • Visceral adipose tissue releases a variety of adipokines which together determine a comprehensive cardiometabolic risk profile. (who.int)
  • As the master regulator of systemic lipid storage and through secretion of a number of these adipokines, adipose tissue has an influence on many processes, including energy metabolism, inflammation, and pathophysiological changes such as cancer and infectious disease ( 4 ). (diabetesjournals.org)
  • Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fat cells produce a plethora of factors, called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. (sergas.gal)
  • Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a class of molecules collectively called adipokines. (nature.com)
  • Obesity affects about 520 million people world-wide and more recently studies have shown that fat cells produce proteins called adipokines which have various influences on the human metabolism and has helped to change the perspectives of researchers on the concept of the adipose tissue being just a store of energy. (openrepository.com)
  • [10-12] In addition to deposition and expenditure of energy, adipose tissues are probably the largest endocrine organ in the body, which produce a myriad of endocrine hormones and adipokines. (lww.com)
  • Lastly, I investigated the effects of maternal exposure to obesity-inducing high fat diet or adipose-tissue derived adipokine leptin during pregnancy on offspring's risk of endometrial carcinogenesis in Pten+/- and wild type mice. (georgetown.edu)
  • Adipose tissue is not considered anymore as a passive depot for storing excess energy in the form of triglycerides but as an active organ secreting several hormones or adipokines. (bvsalud.org)
Obesity8
  • Compelling evidence directly links the adverse proinflammatory adipokine profile in obesity with a spectrum of detrimental cardio-metabolic effects including hepatic, skeletal muscle, and myocardial insulin resistance, hypertension, atherosclerosis, hypercoagulability, thrombosis, and endothelial and cardiac dysfunction. (aston.ac.uk)
  • Therefore, Adipokines have also became a pivotal target for treatment of obesity, dyslipidemia and hyperglycemia. (biomedcentral.com)
  • Adipokines and the intervertebral disc: does a biochemical link exist between obesity and back pain? (ox.ac.uk)
  • Adipokines are peptides, secreted by adipocytes and other cell types with targets in other tissues, participating in a complex network of humoral factors involved in obesity, insulin resistance, and cardiovascular (CV) disease. (uab.edu)
  • The Role of adipokines in obesity related beta-cell failure of diabetes mellitus and endothelial cell dysfunction of cardiovascular diseases. (openrepository.com)
  • As a result of this, adipokines have been reported to represent a connection between obesity and cardiovascular diseases (CVD) and diabetes mellitus. (openrepository.com)
  • A series of tests pointed to a specific enzyme called adipokine nicotinamide phosphoribosyltransferase, (NAMPT), which is known to be involved in some of the pathological metabolic problems caused by obesity. (eurekalert.org)
  • Polymorphisms in Adipokines in Mexican Children with Obesity. (cdc.gov)
Oxidative stress5
  • The aim of the present study was to examine the effect of exercise training on adipokines, inflammatory markers, and oxidative stress in overweight children. (umn.edu)
  • 05) but did not change any of the measured adipokines or the marker of systemic oxidative stress, 8-isoprostane. (umn.edu)
  • These data suggest that in the absence of weight loss, exercise training alone does not improve the adipokine profile or levels of oxidative stress in overweight children. (umn.edu)
  • inflammatory and oxidative stress markers, and adipokines will be evaluated in a subsample. (clinicaltrials.gov)
  • Hess DA and Hegele RA Linking diabetes with oxidative stress, adipokines, and impaired endothelial precursor cell function. (stemcellsportal.com)
Adipocytes4
  • In several animal models, it has now been clearly demonstrated that the induction of a controlled but sustained mitochondrial uncoupling can limit the lipid accumulation in adipocytes, limiting the deleterious effects associated with adipocyte hypertrophy such as organelle dysfunction and alterations in the expression of genes encoding adipokines. (unamur.be)
  • Indeed, it is now commonly admitted that adipocytes also behave as key endocrine cells by synthesizing and secreting more than 600 adipokines. (unamur.be)
  • The aims of the present study was 1) to characterize the effect(s) of a mild mitochondrial uncoupling in 3T3-L1 adipocytes induced by a prolonged incubation (3 days) with low concentration (0.5 μM) of a chemical mitochondrial uncoupler such as FCCP (carbonyl cyanide-4- (trifluoromethoxy)phenylhydrazone) on lipolysis and 2) to analyze the expression of several genes encoding adipokines in adipocytes exposed to the uncoupler. (unamur.be)
  • In the second part of this work, we identified several adipokines that are differentially expressed at the protein and/or at the mRNA level(s) in adipocytes exposed to FCCP. (unamur.be)
Concentrations3
  • Prediagnostic circulating adipokine concentrations and risk of renal cell carcinoma in male smokers. (arctichealth.org)
  • Linear regression models with adaptive elastic-net (AENET) were fit to identify metals associated with adipokines and to compute estimated percent changes in adipokines for one standard deviation increase in log-transformed urinary metal concentrations. (cdc.gov)
  • The concentrations and the bases of the effects of the adipokines in beta cell failure of diabetes mellitus and endothelial cell dysfunction of cardiovascular diseases are still not fully understood. (openrepository.com)
Inflammation3
  • Besides, inflammation and deregulation of adipokines secretion have been recognized as pivotal factors that contribute to the pathogenesis of these conditions. (biomedcentral.com)
  • Our findings indicated that vitamin D insufficiency in MetS patients is associated with increased inflammation and serum adipokine abnormalities which may be associated with developing metabolic complications in these patients. (biomedcentral.com)
  • Objective Chemerin, a recently identified adipokine, has been linked to adiposity, insulin resistance, metabolic syndrome risk factors and inflammation. (elsevier.com)
Resistin1
  • Additional proteins have joined this exclusive club of adipocyte-specific secretory proteins since then, including adipokines such as resistin ( 11 , 12 ) and acylation-stimulating protein ( 13 ), as well as the recently described visfatin ( 14 , 15 ) and retinol-binding protein-4 ( 16 ). (diabetesjournals.org)
Cytokines2
  • The aim of this study was to assess the concentration of selected pro-inflammatory adipokines and cytokines in the unstimulated saliva of obese people with fatty liver disease in various stages (with or without slight fibrosis ) and to analyze them for possible use as early markers of NAFLD diagnosis . (bvsalud.org)
  • Fat tissue produces proteins called cytokines, chemokines, and adipokines. (medicalnewstoday.com)
Biomarkers2
  • Circulating inflammatory biomarkers, adipokines and breast cancer risk-a case-control study nested within the EPIC cohort. (who.int)
  • The regulation and imbalance expression of the novel biomarkers, including inflammatory adipokine, macrophage infiltration, angiogenesis, and lymphangiogenesis in EAT and PAT, may be related to the pathogenesis of CAD. (bvsalud.org)
Chemerin1
  • Thus, the adipokine chemerin likely regulates adipocyte function by autocrine/paracrine mechanisms. (nih.gov)
Adipocyte-derived1
  • This leads to a dysregulation of triglyceride and free fatty acid levels, as well as a dysregulation of specific adipocyte-derived secretory proteins, a group of proteins that we refer to as adipokines. (diabetesjournals.org)
Markers4
  • In conclusion, pre- and post-LT changes in serum adipokine and inflammatory markers may be signals of an increased risk of CV events after LT, but further study is needed. (elsevier.com)
  • Therefore, we assessed whether serum vitamin D status is associated with serum levels of adipokines and inflammatory markers in these patients. (biomedcentral.com)
  • Considering limited data available on this subject, especially in developing countries, we examined vitamin D status in relation to adipokines and inflammatory markers in patients with metabolic syndrome in a case-control study. (biomedcentral.com)
  • This review aims to determine the impact of exercise on cytokine and adipokine profile levels as inflammatory markers in MS patients across various exercise paradigms. (bvsalud.org)
Obese5
  • Pro-Inflammatory Adipokine and Cytokine Profiles in the Saliva of Obese Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)-A Pilot Study. (bvsalud.org)
  • Effect of Testosterone Treatment on Adipokines and Gut Hormones in Obese Men on a Hypocaloric Diet. (austin.org.au)
  • Adipokines and genetic factors in overweight or obese but metabolically healthy Polish women. (nel.edu)
  • Bik W, Ostrowski J, Baranowska-Bik A, Wolinska-Witort E, Bialkowska M, Martynska L, Baranowska B. Adipokines and genetic factors in overweight or obese but metabolically healthy Polish women. (nel.edu)
  • Recently cartonectin was reported as a novel adipokine, with lower levels in diet-induced obese mice, glucose-lowering effects, and antiinflammatory and cardioprotective properties. (webpediatrica.com)
Coronary2
  • Particular emphasis is placed on the action of adipokines in the coronary circulation - especially effects of adipokines on endothelial function, as endothelial damage is likely a critical event initiating atherosclerotic coronary artery disease. (unthsc.edu)
  • In this study, we explored the relationship between inflammatory adipokine levels and coronary artery disease (CAD). (bvsalud.org)
Anti-inflammatory2
  • Serum pro- and anti-inflammatory adipokine levels were higher and lower, respectively, in the CAD group than those in the control group (P (bvsalud.org)
  • Pro-inflammatory adipokine mRNA expression was increased, while anti-inflammatory adipokine mRNA expression decreased, in CAD relative to NCAD in EAT and PAT rather than SAT. In EAT, adipocyte area and macrophage-specific staining were lower, while lymphatic vessel marker expression was higher in CAD. (bvsalud.org)
Serum levels1
  • The serum levels of inflammatory adipokines may correlate to CAD, which requires large sample size studies to get further validation before clinic practice. (bvsalud.org)
Adiposity1
  • There was no relationship between adiposity or adipokines and total IgE levels, blood eosinophil counts, and exhaled nitric oxide levels. (elsevier.com)
Hormones released2
Dysfunction2
  • Our study shows that CoQ10 ameliorates glucolipid profile and adipokines dysfunction in dyslipidemic patients in 24 weeks' intervention. (biomedcentral.com)
  • This review presents basic historical background information on the major adipokines, introduces findings from clinical studies associating adipokines with cardiovascular disease, and summarizes results from recent basic science research studies of mechanisms of adipokine-induced cardiovascular dysfunction. (unthsc.edu)
Cardiovascular diseases2
  • Adipokines as possible new predictors of cardiovascular diseases: a case control study. (unifi.it)
  • Adipokines as possible new predictors of cardiovascular diseases: a case control study / L. Pala;M. Monami;S. Ciani;I. Dicembrini;A. Pasqua;A. Pezzatini;P. Francesconi;B. Cresci;E. Mannucci;C. M. Rotella. (unifi.it)
Metabolism3
  • Adipokines exert pleiotropic effects on target tissues/organs thereby regulating energy homeostasis, metabolism, and insulin sensitivity, as well as immune and cardiovascular functions. (aston.ac.uk)
  • The hypothesis that adipokines mediate the association of CoQ10 on glucolipid metabolism needs to be further studied in human. (biomedcentral.com)
  • These adipokines play crucial roles in whole-body metabolism with different mechanisms of action largely dependent on the tissue or cell type they are acting on. (portlandpress.com)
MetS1
  • The link between this vitamin and adipokines and inflammatory factors, especially in MetS patients, received less attention. (biomedcentral.com)
Osteoarthritis2
  • In this paper, we review the role of adipokines and highlight the cellular and molecular mechanisms at play in osteoarthritis elicited by adipokines. (sergas.gal)
  • We also emphasize how defining the role of adipokines has broadned our understanding of the diversity of factors involved in the genesis and progression of osteoarthritis in the hope of modifying it to prevent and treat diseases. (sergas.gal)
Levels3
  • In the nontransplant setting, aberrant serum adipokine levels are associated with cardiovascular (CV) disease. (elsevier.com)
  • The effects of liver transplantation (LT) on serum adipokine levels and their association with post-LT CV disease have not been studied. (elsevier.com)
  • In CAD, the pro-inflammatory adipokine levels via ELISA in EAT and PAT were elevated. (bvsalud.org)
Processes1
  • Various relationships and emergent processes in the adipokine-CV system network are discussed, with the most significant interactors being responses to hypoxia, regulation of cell migration, effects on blood coagulation, and platelet activation. (uab.edu)
Role2
  • However, the role of c-Cbl in adipokine expression is currently unknown. (bl.uk)
  • As more translatable information about the larger adipokine-CV-lifestyle network is acquired from laboratory and clinical research, the strategic and precise role of lifestyle intervention can be fashioned to improve CV outcomes. (uab.edu)
Inflammatory state1
  • multiple cell types whose collective secretome, termed as adipokines , is highly interdependent on metabolic homeostasis and inflammatory state. (portlandpress.com)
Effects2
  • This review describes recent information about adipokine effects on the CV system. (uab.edu)
  • Rather than simply providing a listing of adipokines and their respective effects, network analysis is used to enhance understanding. (uab.edu)
Urinary1
  • Urinary metals and adipokines in midlife women: the Study of Women's Health Across the Nation (SWAN). (cdc.gov)
Pregnancy1
Hypoadiponectinemia: A Link between Visceral Obesity and Metabolic Syndrome
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Osteoarthritis Workup: Approach Considerations, Plain Radiography, MRI, CT, and Ultrasonography
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Osteoarthritis Treatment & Management: Approach Considerations, Pharmacologic Treatment, Lifestyle Modification, Physical...
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Osteoarthritis: Practice Essentials, Background, Anatomy
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Adipose Tissue | Diabetes | American Diabetes Association
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Leptin in the interplay of inflammation, metabolism and immune system disorders | Nature Reviews Rheumatology
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Obesity, kidney dysfunction and hypertension: mechanistic links | Nature Reviews Nephrology
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Androgen Excess: Practice Essentials, Pathophysiology, Epidemiology
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Preventing Chronic Disease | In Search of a Germ Theory Equivalent for Chronic Disease - CDC
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Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery | eLife
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Osteoarthritis Guidelines: Guidelines Summary, Hand Osteoarthritis, Knee Osteoarthritis
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Nutrients | Free Full-Text | Effect of Fucoidan on Anterior Cruciate Ligament Transection and Medial Meniscectomy Induced...
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Psoriatic arthritis and weight gain: What is the link?
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Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness
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(researchgate.net)
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Fat Hormones, Adipokines<...
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