Adipocytes
PPAR gamma
CCAAT-Enhancer-Binding Protein-alpha
A CCAAT-enhancer-binding protein found in LIVER; ADIPOSE TISSUE; INTESTINES; LUNG; ADRENAL GLANDS; PLACENTA; OVARY and peripheral blood mononuclear cells (LEUKOCYTES, MONONUCLEAR). Experiments with knock-out mice have demonstrated that CCAAT-enhancer binding protein-alpha is essential for the functioning and differentiation of HEPATOCYTES and ADIPOCYTES.
Cell Differentiation
CCAAT-Enhancer-Binding Protein-beta
Adipose Tissue
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Adipose Tissue, White
Adipocytes, White
Adipocytes, Brown
3T3 Cells
Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.
Mesenchymal Stromal Cells
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Receptors, Cytoplasmic and Nuclear
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
Thiazolidinediones
Gene Expression Regulation
Obesity
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Transcription Factors
CCAAT-Enhancer-Binding Proteins
A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.
Anti-Obesity Agents
Fatty Acid-Binding Proteins
Lipid Metabolism
CCAAT-Enhancer-Binding Protein-delta
Gene Knockdown Techniques
Cells, Cultured
Mice, Obese
RNA, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Reverse Transcriptase Polymerase Chain Reaction
Endrin
Fibroblasts
Lipodystrophy
A collection of heterogenous conditions resulting from defective LIPID METABOLISM and characterized by ADIPOSE TISSUE atrophy. Often there is redistribution of body fat resulting in peripheral fat wasting and central adiposity. They include generalized, localized, congenital, and acquired lipodystrophy.
1-Methyl-3-isobutylxanthine
Wnt Proteins
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.
Osteoblasts
Adiposity
Graves Ophthalmopathy
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Stem Cells
Lipogenesis
Adipose Tissue, Brown
RNA Interference
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Stromal Cells
Nuclear Receptor Subfamily 1, Group D, Member 1
A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. The Nr1d1 nuclear receptor expression is cyclically-regulated by a feedback loop involving its positive regulation by CLOCK PROTEIN; BMAL1 PROTEIN heterodimers and its negative regulation by CRYPTOCHROME and PERIOD PROTEINS.
Down-Regulation
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Chromatin Immunoprecipitation
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
Intercellular Signaling Peptides and Proteins
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
NIH 3T3 Cells
A continuous cell line of high contact-inhibition established from NIH Swiss mouse embryo cultures. The cells are useful for DNA transfection and transformation studies. (From ATCC [Internet]. Virginia: American Type Culture Collection; c2002 [cited 2002 Sept 26]. Available from http://www.atcc.org/)
Induction of chondro-, osteo- and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: effect of cofactors on differentiating lineages. (1/1177)
BACKGROUND: Recently, tissue engineering has merged with stem cell technology with interest to develop new sources of transplantable material for injury or disease treatment. Eminently interesting, are bone and joint injuries/disorders because of the low self-regenerating capacity of the matrix secreting cells, particularly chondrocytes. ES cells have the unlimited capacity to self-renew and maintain their pluripotency in culture. Upon induction of various signals they will then differentiate into distinctive cell types such as neurons, cardiomyocytes and osteoblasts. RESULTS: We present here that BMP-2 can drive ES cells to the cartilage, osteoblast or adipogenic fate depending on supplementary co-factors. TGFbeta1, insulin and ascorbic acid were identified as signals that together with BMP-2 induce a chondrocytic phenotype that is characterized by increased expression of cartilage marker genes in a timely co-ordinated fashion. Expression of collagen type IIB and aggrecan, indicative of a fully mature state, continuously ascend until reaching a peak at day 32 of culture to approximately 80-fold over control values. Sox9 and scleraxis, cartilage specific transcription factors, are highly expressed at very early stages and show decreased expression over the time course of EB differentiation. Some smaller proteoglycans, such as decorin and biglycan, are expressed at earlier stages. Overall, proteoglycan biosynthesis is up-regulated 7-fold in response to the supplements added. BMP-2 induced chondrocytes undergo hypertrophy and begin to alter their expression profile towards osteoblasts. Supplying mineralization factors such as beta-glycerophosphate and vitamin D3 with the culture medium can facilitate this process. Moreover, gene expression studies show that adipocytes can also differentiate from BMP-2 treated ES cells. CONCLUSIONS: Ultimately, we have found that ES cells can be successfully triggered to differentiate into chondrocyte-like cells, which can further alter their fate to become hypertrophic, and adipocytes. Compared with previous reports using a brief BMP-2 supplementation early in differentiation, prolonged exposure increased chondrogenic output, while supplementation with insulin and ascorbic acid prevented dedifferentiation. These results provide a foundation for the use of ES cells as a potential therapy in joint injury and disease. (+info)Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice. (2/1177)
OBJECTIVE: A potential role of growth arrest-specific gene 6 (Gas-6) in energy storage in adipose tissue was investigated in murine models of obesity. Gas-6 is a ligand for the Axl, C-Mer, and Sky family of tyrosine kinase receptors. METHODS AND RESULTS: Whereas Gas-6, C-Mer, and Sky were expressed in mature murine adipocytes, the expression of Axl was restricted to the stromal-vascular fraction, which includes pre-adipocytes. During the in vitro conversion of adipogenic 3T3-F442A cells into mature adipocytes, the expression of Gas-6 increased in undifferentiated confluent pre-adipocytes during a transient phase of growth arrest. On treatment of these cells with an adipogenic medium, Gas-6 expression decreased sharply, coinciding with expression of early adipocytes markers. This modulation was not observed in the nonadipogenic 3T3-C2 cells. The Gas-6 mRNA level was transiently downregulated during nutritionally induced expansion of adipose tissues in vivo. When kept on a standard diet, no significant difference in either total body weight or weight of gonadal or subcutaneous fat pads was observed between Gas-6 deficient and wild-type mice. On exposure to a high-fat diet, however, Gas-6-deficient mice had significantly less fat mass than their wild-type counterparts. CONCLUSIONS: Gas-6 enhances the accumulation of adipose tissue in diet-induced obese mice. (+info)Mesenchymal stem cells from the outer ear: a novel adult stem cell model system for the study of adipogenesis. (3/1177)
Adipocytes arise from multipotent stem cells of mesodermal origin, which also give rise to the muscle, bone, and cartilage lineages. However, signals and early molecular events that commit multipotent stem cells into the adipocyte lineage are not well established mainly due to lack of an adequate model system. We have identified a novel source of adult stem cells from the external murine ears referred to here as an ear mesenchymal stem cells (EMSC). EMSC have been isolated from several standard and mutant strains of mice. They are self-renewing, clonogenic, and multipotent, since they give rise to osteocytes, chondrocytes, and adipocytes. The in vitro characterization of EMSC indicates very facile adipogenic differentiation. Morphological, histochemical, and molecular analysis after the induction of differentiation showed that EMSC maintain adipogenic potentials up to fifth passage. A comparison of EMSC to the stromal-vascular (S-V) fraction of fat depots, under identical culture conditions (isobutyl-methylxanthine, dexamethasone, and insulin), revealed much more robust and consistent adipogenesis in EMSC than in the S-V fraction. In summary, we show that EMSC can provide a novel, easily obtainable, primary culture model for the study of adipogenesis. (+info)Generation of a vascularized organoid using skeletal muscle as the inductive source. (4/1177)
The technology required for creating an in vivo microenvironment and a neovasculature that can grow with and service new tissue is lacking, precluding the possibility of engineering complex three-dimensional organs. We have shown that when an arterio-venous (AV) loop is constructed in vivo in the rat groin, and placed inside a semisealed chamber, an extensive functional vasculature is generated. To test whether this unusually angiogenic environment supports the survival and growth of implanted tissue or cells, we inserted various preparations of rat and human skeletal muscle. We show that after 6 weeks incubation of muscle tissue, the chamber filled with predominantly well-vascularized recipient-derived adipose tissue, but some new donor-derived skeletal muscle and connective tissue were also evident. When primary cultured myoblasts were inserted into the chamber with the AV loop, they converted to mature striated muscle fibers. Furthermore, we identify novel adipogenesis-inducing properties of skeletal muscle. This represents the first report of a specific three-dimensional tissue grown on its own vascular supply. (+info)The transcription factor GATA2 regulates differentiation of brown adipocytes. (5/1177)
Brown adipose tissue (BAT) is a specialized mammalian tissue and a site of adaptive thermogenesis. Although the metabolic functions of brown and white adipocytes are distinct, terminal differentiation of both adipocyte lineages is regulated by well-characterized common transcription factors. However, the early stages of adipocyte differentiation and regulation of precursor cells are not well understood. We report here that GATA2 is expressed in brown adipocyte precursors, and its expression is downregulated in a differentiation-dependent manner. Constitutive expression of GATA2 suppressed expression of BAT-specific genes in brown adipocytes, whereas disruption of a GATA2 allele in brown preadipocytes resulted in significantly elevated differentiation and expression of several markers of brown adipogenesis. Collectively, these results show that GATA2 functions to suppress brown adipocyte differentiation, whereas reduction of GATA2 promotes brown adipogenesis. (+info)The G0/G1 switch gene 2 is a novel PPAR target gene. (6/1177)
PPARs (peroxisome-proliferator-activated receptors) alpha, beta/delta and gamma are a group of transcription factors that are involved in numerous processes, including lipid metabolism and adipogenesis. By comparing liver mRNAs of wild-type and PPARalpha-null mice using microarrays, a novel putative target gene of PPARalpha, G0S2 (G0/G1 switch gene 2), was identified. Hepatic expression of G0S2 was up-regulated by fasting and by the PPARalpha agonist Wy14643 in a PPARalpha-dependent manner. Surprisingly, the G0S2 mRNA level was highest in brown and white adipose tissue and was greatly up-regulated during mouse 3T3-L1 and human SGBS (Simpson-Golabi-Behmel syndrome) adipogenesis. Transactivation, gel shift and chromatin immunoprecipitation assays indicated that G0S2 is a direct PPARgamma and probable PPARalpha target gene with a functional PPRE (PPAR-responsive element) in its promoter. Up-regulation of G0S2 mRNA seemed to be specific for adipogenesis, and was not observed during osteogenesis or myogenesis. In 3T3-L1 fibroblasts, expression of G0S2 was associated with growth arrest, which is required for 3T3-L1 adipogenesis. Together, these data indicate that G0S2 is a novel target gene of PPARs that may be involved in adipocyte differentiation. (+info)Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. (7/1177)
Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. Here, we established its involvement in the control of adipogenesis and lipid metabolism activity in mature adipocytes. During adipose differentiation in 3T3-L1 cells, the level of BMAL1 mRNA began to increase 4 days after induction and was highly expressed in differentiated cells. In white adipose tissues isolated from C57BL/6J mice, BMAL1 was predominantly expressed in a fraction containing adipocytes, as compared with the stromal-vascular fraction. BMAL1 knockout mice embryonic fibroblast cells failed to be differentiated into adipocytes. Importantly, adding BMAL1 back by adenovirus gene transfer restored the ability of BMAL1 knockout mice embryonic fibroblast cells to differentiate. Knock-down of BMAL1 expression in 3T3-L1 cells by an RNA interference technique allowed the cells to accumulate only minimum amounts of lipid droplets in the cells. Adenovirus-mediated expression of BMAL1 in 3T3-L1 adipocytes resulted in induction of several factors involved in lipogenesis. The promoter activity of these genes was stimulated in a BMAL1-dependent manner. Interestingly, expression of these factors showed clear circadian rhythm in mice adipose tissue. Furthermore, overexpression of BMAL1 in adipocytes increased lipid synthesis activity. These results indicate that BMAL1, a master regulator of circadian rhythm, also plays important roles in the regulation of adipose differentiation and lipogenesis in mature adipocytes. (+info)Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics. (8/1177)
Differentiation of multipotent mesenchymal stem cells into lipid-accumulating adipocytes is a physiological process induced by transcription factors in combination with hormonal stimulation. We have used Affymetrix microarrays to compare the adipogenic differentiation pathways of NIH-3T3 fibroblasts induced to undergo in vitro differentiation by ectopic expression of early B cell factor (EBF)-1 or peroxisome proliferator-activated receptor (PPAR)gamma2. These experiments revealed that commitment to the adipogenic pathway in the NIH-3T3 cells was not reflected in gene expression until 4 days after induction of differentiation. Furthermore, gene expression patterns at the earlier time points after stimulation indicated that EBF-1 and PPARgamma2 induced different sets of genes, while the similarities increased upon differentiation, and that several genes linked to adipocyte differentiation were also transiently induced in the vector-transduced cells. These data suggest that the initial activation of genes associated with adipocyte development is independent of commitment to the adipogenic pathway and that EBF-1 and PPARgamma2 induce adipocyte differentiation with comparable kinetics and efficiency. (+info)
Comprehensive transcriptome analysis of mouse embryonic stem cell adipogenesis unravels new processes of adipocyte development ...
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Early-Life Programming of Adipogenesis and Adiposity - Adipose Tissue in Health and Disease - Cripps - Wiley Online Library
Expression of Nuclear Receptors during Adipogenesis of 3T3-L1 Cells COUP-TFI COUP-TFII PPAR VDR GCNF ROR HNF4 LXR LXR ...
Differential effects of fibroblast growth factor and tumor promoters on the initiation and maintenance of adipocyte...
JCI -
Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis
Srujana Rayalam, PhD
Kindkes Scrap Notes: High glucose induces adipogenic differentiation
Molecules and Cells
Pennington Biomedical Research Center
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HUMAN EXCRETORY SYSTEM - ppt download
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rs10483032 - SNPedia
Dynamic upregulation of CD24 in pre-adipocytes promotes adipogenesis - Memorial University Research Repository
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Proteomic Analysis of Bovine Longissimus Muscle Satellite Cells during Adipogenic Differentiation
Decreased RB1 mRNA, Protein, and Activity Reflect Obesity-Induced Altered Adipogenic Capacity in Human Adipose Tissue
Effect of germinated brown rice extracts on pancreatic lipase, adipogenesis and lipolysis in 3T3-L1 adipocytes<...
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Beta-mecaptoethanol suppresses inflammation and induces adipogenic differentiation in 3T3-F442A murine preadipocytes<...
CD90 serves as differential modulator of subcutaneous and visceral adipose-derived stem cells by regulating AKT activation that...
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Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of β...
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Adipogenesis
... and triiodothyronine effectively induce adipogenesis in preadipocytes. Insulin regulates adipogenesis through insulin-like ... Reduced adipogenesis in obese persons is due to increased senescent cells in adipose tissue rather than reduced numbers of stem ... Adipogenesis is the formation of adipocytes (fat cells) from stem cells. It involves 2 phases, determination, and terminal ... cAMP, an inducer of adipogenesis, can promote expression of C/EBPβ and C/EBPδ. At the early stage of differentiation, the ...
Forkhead box protein O1
The failure to commit to adipogenesis is primarily due to active FOXO1 arresting the cell in G0/G1 through activation of yet ... FOXO1 negatively regulates adipogenesis. Presently, the exact mechanism by which this is accomplished is not entirely ... Rising levels of PPARG are required to initiate adipogenesis; by preventing its transcription, FOXO1 is preventing the onset of ... In the currently accepted model, FOXO1 negatively regulates adipogenesis by binding to the promoter sites of PPARG and ...
Firre
It plays a role in pluripotency and adipogenesis. Long non-coding RNA GRCh38: Ensembl release 89: ENSG00000213468 - Ensembl, ... "Long noncoding RNAs regulate adipogenesis". Proceedings of the National Academy of Sciences of the United States of America. ...
MicroRNA
Studies to determine what role pluripotent stem cells play in adipogenesis, were examined in the immortalized human bone marrow ... Romao JM, Jin W, Dodson MV, Hausman GJ, Moore SS, Guan LL (September 2011). "MicroRNA regulation in mammalian adipogenesis". ... Conversely, ectopic expression of the miRNAs 155, 221, and 222 significantly inhibited adipogenesis and repressed induction of ... alpha expression by C/EBP beta during adipogenesis requires a peroxisome proliferator-activated receptor-gamma-associated ...
Yihai Cao
Cao, Yihai (2007-09-01). "Angiogenesis modulates adipogenesis and obesity". The Journal of Clinical Investigation. 117 (9): ...
Lipoblast
Adipogenesis Adipose differentiation-related protein Lipoblastoma List of human cell types derived from the germ layers Michael ... Dani C (1999). "Embryonic stem cell-derived adipogenesis". Cells Tissues Organs (Print). 165 (3-4): 173-80. doi:10.1159/ ...
DEPTOR
... cell-autonomously regulates adipogenesis. In the muscle, Baf60c promotes a switch from oxidative to glycolytic myofiber ... "DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity". Cell Metabolism. 16 (2): 202-12 ...
WNT10B
2000). "Inhibition of adipogenesis by Wnt signaling". Science. 289 (5481): 950-3. Bibcode:2000Sci...289..950R. doi:10.1126/ ... a molecular switch that governs adipogenesis. Gain-of-function of Wnt10b in mouse hearts has shown to improve cardiac tissue ...
GPR 120
... is also a key regulator of adipogenesis, including adipocyte development and differentiation. Oh, Da Young; Talukdar, ... 2007). "The regulation of adipogenesis through GPR120". Biochemical and Biophysical Research Communications. 354 (2): 591-7. ...
STC1
Serlachius M, Andersson LC (Jun 2004). "Upregulated expression of stanniocalcin-1 during adipogenesis". Experimental Cell ...
Let-7 microRNA precursor
Sun T, Fu M, Bookout AL, Kliewer SA, Mangelsdorf DJ (2009). "MicroRNA let-7 Regulates 3T3-L1 Adipogenesis". Mol Endocrinol. 23 ...
NEDD8
PPARγ has a crucial role in adipogenesis and lipid accumulation within adipocytes (fat cells). Activated NEDD8 stabilizes PPARγ ... allowing increased adipogenesis. In experiments with mice, Pevonedistat, a drug inhibiting activation of NEDD8, prevented high- ... "PPARγ neddylation essential for adipogenesis is a potential target for treating obesity". Cell Death and Differentiation. 23 (8 ...
ADAM12
"ADAM 12 protease induces adipogenesis in transgenic mice". Am. J. Pathol. 160 (5): 1895-903. doi:10.1016/S0002-9440(10)61136-4 ...
Cycloleucine
In a 2015 study on the role of N6-methyladenosine (m6A) demethylation on adipogenesis, researchers treated porcine adipocytes ... Wang, Xinxia; Zhu, Linna; Chen, Jingqing; Wang, Yizhen (2015-04-03). "mRNA m6A Methylation Downregulates Adipogenesis In ...
Follistatin
August 2009). "Role of follistatin in promoting adipogenesis in women". The Journal of Clinical Endocrinology and Metabolism. ...
N6-Methyladenosine
"FTO influences adipogenesis by regulating mitotic clonal expansion". Nature Communications. 6: 6792. Bibcode:2015NatCo...6.6792 ... "FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis". Cell Research. 24 ...
Agouti-signaling protein
"Adipogenesis and obesity: rounding out the big picture". Cell. 87 (3): 377-89. doi:10.1016/S0092-8674(00)81359-8. PMID 8898192 ...
Oxylipin
Barquissau V, Ghandour RA, Ailhaud G, Klingenspor M, Langin D, Amri EZ, Pisani DF (2017). "Control of adipogenesis by oxylipins ...
Cathepsin
Mouse cathepsin L is homologous to human cathepsin V. Mouse cathepsin L has been shown to play a role in adipogenesis and ... "Cathepsin L activity controls adipogenesis and glucose tolerance". Nat. Cell Biol. 9 (8): 970-7. doi:10.1038/ncb1623. PMC ...
Jeffrey Flier
Cited 1373 times, June 2022 Spiegelman, B. M.; Flier, J. S. (1996-11-01). "Adipogenesis and obesity: rounding out the big ...
KMT2D
KMT2C and KMT2D are essential for adipogenesis and myogenesis. Similar functions are seen in neuronal and osteoblast ... "MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis". Nucleic Acids ... recruits and requires KMT2D to establish a subset of adipogenic enhancers during adipogenesis. Depletion of KMT2D prior to ...
Oprelvekin
Synonyms are: AGIF Adipogenesis inhibitory factor Interleukin-11 precursor. Oprelvekin is produced in Escherichia coli (E. coli ... the inhibition of adipogenesis, the induction of acute phase protein synthesis (e.g., fibrinogen), and inhibition of ...
Sodium pyruvate
"Exogenous Sodium Pyruvate Stimulates Adipogenesis of 3T3-L1 Cells". Journal of Cellular Biochemistry. 117 (1): 39-48. doi: ...
Super-enhancer
"Molecular architecture of transcription factor hotspots in early adipogenesis". Cell Reports. 7 (5): 1434-42. doi:10.1016/j. ...
Acetyl-CoA carboxylase
"A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis". The Journal of Biological Chemistry. 277 (19): ...
Bone morphogenetic protein
BMPs are also involved in adipogenesis and functional regulation of adipose tissue. BMP4 favors white adipogenesis, whereas ...
MiR-27
Lin Q, Gao Z, Alarcon RM, Ye J, Yun Z (2009). "A role of miR-27 in the regulation of adipogenesis". FEBS J. 276 (8): 2348-58. ... acting by blocking the expression of two main regulators of adipogenesis. MicroRNAs miR-27a and -27b have been found to ...
Chemerin
... a new adipokine that modulates adipogenesis via its own receptor". Biochem. Biophys. Res. Commun. 362 (4): 1013-8. doi:10.1016/ ... a novel adipokine that regulates adipogenesis and adipocyte metabolism". J. Biol. Chem. 282 (38): 28175-88. doi:10.1074/jbc. ...
CMKLR1
As an adipokine receptor it has a role in adipogenesis and adipocyte maturation. It seems also to have a role in peripheral ... a novel adipokine that regulates adipogenesis and adipocyte metabolism". The Journal of Biological Chemistry. 282 (38): 28175- ...
Obesogen
Janesick A, Blumberg B (March 2011). "Endocrine disrupting chemicals and the developmental programming of adipogenesis and ... "Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates" (PDF). Mol. Endocrinol. 20 (9): ... Monoethyl-hexyl-phthalate Is a Selective Peroxisome Proliferator-activated Receptor γ Modulator That Promotes Adipogenesis". J ...
Chemerin--a new adipokine that modulates adipogenesis via its own receptor
NOVEL ROLES OF THE CILIARY GENES, THM1 AND THM2, IN ADIPOGENESIS, SKELETAL DEVELOPMENT, AND SPERMATOGENESIS
Role of murine macrophage in temporal regulation of cortisol- and serotonin-induced adipogenesis in pre-adipocytes when grown...
Regulation of adipogenesis, the root cause for obesity, is very poorly understood. However, studies have presented evidence of ... Kinetic profile of adipogenesis genes. (A) Differentially expressed genes in co-cultured adipocytes treated with cortisol, ... Kinetic profile of adipogenesis genes. (A) Differentially expressed genes in co-cultured adipocytes treated with cortisol, ... Role of macrophage in TNF and associated signalling to induce adipogenesis in pre-adipocytes. Studies have associated inflamed ...
FGF signaling promotes precursor spreading for adult adipogenesis in Drosophila - preLights
The authors then turn to the role of FGF signalling in adult adipogenesis. They find expression of the FGF receptor heartless ( ... Thus, it provides strong evidence for de novo adipogenesis rather than for derivation of the adult fat body from persisting ... FGF signaling promotes precursor spreading for adult adipogenesis in Drosophila. Yuting Lei, Yuwei Huang, Ke Yang, Xueya Cao, ... does it come from the persisting larval cells or is there de novo adult adipogenesis? In this study, Lei et al., identify the ...
HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice | BMC...
"Fibrogenesis and Adipogenesis in Farm Animals and Rodents" by Chaoyang Li
Excessive adipogenesis along with fibrogenesis in the chicken breast, unlike in the beef steak, would exert an unpleasant ... we aimed to provide additional insight into the mechanisms of fibrogenesis and adipogenesis based on different animal models to ... Excessive adipogenesis along with fibrogenesis in the chicken breast, unlike in the beef steak, would exert an unpleasant ... In this dissertation, we aimed to provide additional insight into the mechanisms of fibrogenesis and adipogenesis based on ...
ETO/MTG8 is an inhibitor of C/EBP beta activity and a regulator of early adipogenesis<...
ETO/MTG8 is an inhibitor of C/EBP beta activity and a regulator of early adipogenesis. / Rochford, JJ; Semple, RK; Laudes, M et ... ETO/MTG8 is an inhibitor of C/EBP beta activity and a regulator of early adipogenesis. Molecular and Cellular Biology. 2004 Nov ... ETO/MTG8 is an inhibitor of C/EBP beta activity and a regulator of early adipogenesis. In: Molecular and Cellular Biology. 2004 ... Dive into the research topics of ETO/MTG8 is an inhibitor of C/EBP beta activity and a regulator of early adipogenesis. ...
Adipogenesis | Pharmacognosy Journal
IMSEAR at SEARO: Cellular and molecular biology of adiposity and adipogenesis.
adipogenesis - ZooTerms (Dictionary of Invertebrate Zoology)
Direct conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal...
Temporal expression pattern of Bardet-Biedl syndrome genes in adipogenesis<...
keywords = "3T3-F442A, Adipogenesis, Adipose tissue, Bardet-Biedl syndrome, Obesity",. author = "Efrat Forti and Olga Aksanov ... Forti, Efrat ; Aksanov, Olga ; Birk, Ruth Z. / Temporal expression pattern of Bardet-Biedl syndrome genes in adipogenesis. In: ... Forti, E., Aksanov, O., & Birk, R. Z. (2007). Temporal expression pattern of Bardet-Biedl syndrome genes in adipogenesis. ... To date, 11 BBS genes have been cloned (BBS1-BBS11). However, the function of BBS genes in adipogenesis is unknown. Moreover, ...
497 THE ROLE OF FSH IN CASTRATION INDUCED ADIPOGENESIS. HIGHLIGHTING DIFFERENCES BETWEEN ORCHIECTOMY, GNRH AGONISTS AND...
High hydrostatic pressure extract of Siegesbeckia orientalis inhibits adipogenesis through the activation of the Wnt/β-catenin...
SPW-HHPE inhibited adipogenesis by reducing intracellular lipid accumulation. SPW-HHPE reduced the mRNA and protein expression ... SPW-HHPE inhibited adipogenesis by reducing intracellular lipid accumulation. SPW-HHPE reduced the mRNA and protein expression ... SPW-HHPE inhibited adipogenesis by reducing intracellular lipid accumulation. SPW-HHPE reduced the mRNA and protein expression ... SPW-HHPE inhibited adipogenesis by reducing intracellular lipid accumulation. SPW-HHPE reduced the mRNA and protein expression ...
A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation
EFFECT OF HYPEROSIDE ON THE INHIBITION OF ADIPOGENESIS IN 3T3-L1 ADIPOCYTES | AVESİS
Bisecting GlcNAc protein N-glycosylation is characteristic of human adipogenesis - Projects
- Macquarie University
Pyrocatechol, a component of coffee, suppresses LPS-induced inflammatory responses by inhibiting NF-κB and activating Nrf2 |...
The obesity susceptibility gene TMEM18 promotes adipogenesis through direct activation of PPARG signalling :: MPG.PuRe
The obesity susceptibility gene TMEM18 promotes adipogenesis through direct activation of PPARG signalling ... 2019). The obesity susceptibility gene TMEM18 promotes adipogenesis through direct activation of PPARG signalling. Diabetologia ... The obesity susceptibility gene TMEM18 promotes adipogenesis through direct activation of PPARG signalling ...
Plus it
2. Adipogenesis. Synovial membrane-derived cells were seeded (2 × 105 cells/8.6 cm2) and cultured in a one-well chamber slide ... Adipogenesis was induced by culturing for 3 weeks using adipogenic differentiation medium (Cambrex). After fixation in 4% ... adipogenesis by using a stain for lipids, and osteogenesis by detecting calcium deposits. Coexpression of CD44, CD73, CD90, and ...
Infantile Hemangioma Medication: Beta-adrenergic Blocker, Antiglaucoma, Beta-Blockers, Corticosteroids, Interferons, Biologic...
Adenovirus 36 DNA in Adipose Tissue of Patient with Unusual Visceral Obesity - Volume 16, Number 5-May 2010 - Emerging...
Infantile Hemangioma Clinical Presentation: History, Physical Examination, Complications
A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive...
... suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K. ... 3T3-L1 Cells, Adenosine Triphosphate, Adipogenesis, Animals, Binding, Competitive, CCAAT-Enhancer-Binding Protein-alpha, Cell ... Our objective was to determine the effects of 6,7,4-THIF on adipogenesis in 3T3-L1 preadipocytes and elucidate the mechanisms ... METHODS AND RESULTS: Adipogenesis was stimulated in 3T3-L1 preadipocytes. Both 6,7,4-THIF and daidzein were treated in the ...
Metabolism
Interleukin-11 Receptor Subunit Alpha-1 is Required for Maximal Airway Responsiveness to Methacholine After Acute Exposure to...
The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity
... inhibiting adipogenesis and lipogenesis, and suppressing the differentiation of preadipocytes to mature adipocytes. ... Resveratrol can inhibit adipogenesis by reducing the stability and transcriptional activity of PPARγ [78, 79] and prevent ... S. Rayalam, J. Y. Yang, S. Ambati, M. A. Della-Fera, and C. A. Baile, "Resveratrol induces apoptosis and inhibits adipogenesis ... Curcumin may have a significant effect on adipogenesis. In primary human adipocytes and murine 3T3-L1 adipocytes, curcumin ...
Brown adipose tissue and aging : Current Opinion in Clinical Nutrition & Metabolic Care
Endoplasmic Reticulum Stress Regulates Adipocyte Resistin Expression | Diabetes | American Diabetes Association
PPARγ, which is crucial for adipogenesis (34,35), also induces resistin expression during adipocyte differentiation (36). ... Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor ... Sequential gene promoter interactions by C/EBPβ, C/EBPα, and PPARγ during adipogenesis ...
Suppresses adipogenesisAdiposePromotesOsteogenesisRegulationInhibitory EffectAdipocytesAccumulationPreadipocyteMolecular biologyCellsMechanismsReceptorDifferentiationTemporalEarlyExpressionEnvironmentalAnimalsFunctionRoleMouseMesenchymal stemPromotes adipogenesisPreadipocytesRole in adipogenesisCapable of promoting adipogenesisHuman AdipogenesisInduces adipogenesisInhibit adipogenesisLipidEarly phase of adipogenesisMaster regulator of adipogenesisGenesInhibits adipogenesis viaProcess called adipogenesisPPARRegulatorPPARgFunction and adipogenesisAdipose tissueVivoInsulin ResistanceVitro adipogenesisControls adipogenesisMyogenesisInhibitionMRNAInduction2019InhibitorTranscriptionFibroblastsFetalOsteoblastogenesisDiet-induced obesityBonePathways
Suppresses adipogenesis3
- These results suggest that SPW-HHPE suppresses adipogenesis by stimulating Wnt/β-catenin pathway. (elsevier.com)
- A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K. (oregonstate.edu)
- Our results suggest that 6,7,4'-THIF suppresses adipogenesis in 3T3-L1 preadipocytes by directly targeting PI3K. (oregonstate.edu)
Adipose2
- These polyphenols may play beneficial effects on adipose tissue under obese condition by alleviating intracellular oxidative stress, reducing chronic low-grade inflammation, inhibiting adipogenesis and lipogenesis, and suppressing the differentiation of preadipocytes to mature adipocytes. (hindawi.com)
- The aim of this thesis was to develop an in vitro method for studying effects of environmental contaminants on adipogenesis in polar bear by using adipose tissue-derived stem cells derived from polar bear (pbASCs). (uib.no)
Promotes1
- Environmental exposure to benzyl butyl phthalate promotes adipogenesis in the preadipocyte 3T3-L1. (cdc.gov)
Osteogenesis4
- Based on MSC-derived bone formation assays both in vivo and in vitro, azoramide treatment displayed a cell fate determining ability in favor of adipogenesis over osteogenesis. (biomedcentral.com)
- Moreover, both in vitro and in vivo studies have shown that a reciprocal fate decision is frequently observed between adipogenesis and osteogenesis. (biomedcentral.com)
- Chondrogenesis was assessed by staining for proteoglycans and collagen type II, adipogenesis by using a stain for lipids, and osteogenesis by detecting calcium deposits. (jrheum.org)
- The differentiation potentials of osteogenesis, chondrogenesis, and adipogenesis were evaluated with histological staining and quantitative polymerase chain reaction of differentiation marker genes. (researchsquare.com)
Regulation2
- Regulation of adipogenesis, the root cause for obesity, is very poorly understood. (biologists.com)
- EDCs may interact with nuclear receptors (NRs), including NRs involved in regulation of metabolism and adipogenesis, e.g. peroxisome proliferator- activated receptor gamma (PPARγ). (uib.no)
Inhibitory Effect1
- The inhibitory effect of SPW-HHPE on adipogenesis was mainly attributed to the enhancement of the Wnt/β-catenin signaling pathway. (elsevier.com)
Adipocytes1
- shRNA-mediated Thm1 knockdown in 3T3-L1 mouse pre-adipocytes reveals Thm1 deficiency increases adipogenesis and insulin sensitivity, providing an additional mechanism underlying Thm1-deficient obesity. (ku.edu)
Accumulation3
- ETO prevents both the transcriptional activation of the C/EBPalpha promoter by C/EBPbeta and its concurrent accumulation in centromeric sites during early adipogenesis. (elsevier.com)
- SPW-HHPE inhibited adipogenesis by reducing intracellular lipid accumulation. (elsevier.com)
- 6,7,4'-THIF significantly suppressed MDI-induced lipid accumulation in the early stage of adipogenesis, attributable to a suppression of cell proliferation and the induction of cell cycle arrest. (oregonstate.edu)
Preadipocyte1
- 3T3-F442A preadipocyte cells were harvested throughout the adipogenesis process (from day 1 to 8) at 1-day intervals. (bgu.ac.il)
Molecular biology1
- IMSEAR at SEARO: Cellular and molecular biology of adiposity and adipogenesis. (who.int)
Cells1
- However, the origins of the adult fat body are much less clear: does it come from the persisting larval cells or is there de novo adult adipogenesis? (biologists.com)
Mechanisms2
- In this dissertation, we aimed to provide additional insight into the mechanisms of fibrogenesis and adipogenesis based on different animal models to help the discovery of new treatments in cardiovascular disease, beef breeding strategies, and feed nutrition modifications. (lsu.edu)
- Our objective was to determine the effects of 6,7,4'-THIF on adipogenesis in 3T3-L1 preadipocytes and elucidate the mechanisms of action involved. (oregonstate.edu)
Receptor1
- We observed that 6,7,4'-THIF, but not daidzein, inhibited MDI-induced adipogenesis significantly at 40 and 80 μM, associated with decreased peroxisome proliferator-activated receptor-γ and C/EBP-α protein expression. (oregonstate.edu)
Differentiation1
- In this study, microcomputed tomography and histological analysis on bone morphogenetic protein (BMP)2-induced parietal periosteum bone formation assays, C3H10T1/2 and mouse bone marrow MSC-derived bone formation and adipogenesis assays, and specific staining for bone tissue and lipid droplets were used to evaluate the role of azoramide on the lineage determination of MSC differentiation. (biomedcentral.com)
Temporal1
- These findings show for the first time a unique, temporal and synchronized expression of BBS genes during adipogenesis. (bgu.ac.il)
Early2
- Here we show that ETO is highly expressed in preadipocytes and acts as an inhibitor of C/EBPbeta during early adipogenesis, contributing to its characteristically delayed activation. (elsevier.com)
- High-mobility group box 2 protein is essential for the early phase of adipogenesis. (amedeo.com)
Expression2
- ETO expression rapidly reduces after the initiation of adipogenesis, and this is essential to the normal induction of adipogenic gene expression. (elsevier.com)
- The aim of our study was to investigate the expression of BBS genes throughout adipogenesis. (bgu.ac.il)
Environmental2
- Interference by environmental contaminants on NRs regulating adipogenesis in polar bear may affect lipid metabolism and thereby decrease their ability to respond to climate change. (uib.no)
- The use of pbASCs as an in vitro model for effects of environmental contaminants on adipogenesis can provide valuable information on how contaminant exposure can affect energy homeostasis in the polar bear. (uib.no)
Animals3
- Adv 36 causes adipogenesis in animals and humans. (cdc.gov)
- Adipogenesis in mice has alternating genetic requirements throughout the animals' lives. (the-scientist.com)
- These changes are thought to be caused by the action causes adipogenesis in animals and humans. (cdc.gov)
Function3
- Moreover, cAMP-protein kinase A (PKA)-mediated nuclear β-catenin activity was responsible for the negative function of azoramide on bone formation in favor of adipogenesis. (biomedcentral.com)
- However, the function of BBS genes in adipogenesis is unknown. (bgu.ac.il)
- BET bromodomain proteins regulate enhancer function during adipogenesis. (bvsalud.org)
Role1
- The authors then turn to the role of FGF signalling in adult adipogenesis. (biologists.com)
Mouse1
- In addition, loss of β-catenin in the mesenchyme of the developing mouse uterus was found to be a switch to adipogenesis in the myometrium [ 6 ]. (biomedcentral.com)
Mesenchymal stem2
- Taken together, our study demonstrates that SCARA5 is a positive regulator in adipocyte lineage commitment and early adipogenesis in mesenchymal stem cells. (yonsei.ac.kr)
- GNPDA2 Gene Affects Adipogenesis and Alters the Transcriptome Profile of Human Adipose-Derived Mesenchymal Stem Cells. (cdc.gov)
Promotes adipogenesis4
- Vkorc1l1 promotes adipogenesis and possibly obesity. (nih.gov)
- 7. Hydrogen sulfide promotes adipogenesis in 3T3L1 cells. (nih.gov)
- The obesity-susceptibility gene TMEM18 promotes adipogenesis through activation of PPARG. (mpg.de)
- Environmental exposure to benzyl butyl phthalate promotes adipogenesis in the preadipocyte 3T3-L1. (cdc.gov)
Preadipocytes7
- Adipogenesis is induced by treating confluent preadipocytes with the adipogenic cocktail, which activates transcription factors (TFs) glucocorticoid receptor (GR) and CREB within minutes and increases expression of TFs C/EBPβ, C/EBPδ, KLF4, and Krox20 within hours. (nih.gov)
- However, it has remained unclear whether endogenous KLF4 and Krox20 are required for adipogenesis in culture and in vivo Using conditional knockout mice and derived white and brown preadipocytes, we show that endogenous KLF4 and Krox20 are dispensable for adipogenesis in culture and for brown adipose tissue development in mice. (nih.gov)
- When ectopically expressed in preadipocytes, each of these TFs is capable of promoting adipogenesis in culture. (nih.gov)
- Using conditional knockout mice and derived preadipocytes, we demonstrate that endogenous GR is largely dispensable for adipogenesis in culture and brown adipose tissue development in mice. (nih.gov)
- We hypothesized that exposing preadipocytes to TBBPA could influence adipogenesis via genes other than those in the PPARγ pathway due to its structural similarity to bisphenol A, which demonstrates varied endocrine disrupting activities. (nih.gov)
- Using embryonic stem cells and 3T3-L1 preadipocytes, we show that calreticulin modulates adipogenesis. (rupress.org)
- Wnt10b, an endogenous inhibitor of adipogenesis, maintains preadipocytes within an undifferentiated condition by suppressing adipogenic transcription elements. (lifescienceexec.com)
Role in adipogenesis2
- These data suggest stereospecificity of CLA isomers and a possible regulatory role in adipogenesis. (nih.gov)
- [ 16 ] Potential mechanisms through which TCF7L2 variants influence T2DM include its role in adipogenesis, myogenesis, and pancreatic islet development, as well as in beta-cell survival and insulin secretory granule function. (medscape.com)
Capable of promoting adipogenesis1
- All of these TFs have been shown to be capable of promoting adipogenesis in culture when they are overexpressed. (nih.gov)
Human Adipogenesis4
- A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis. (ox.ac.uk)
- The increase in 11beta-HSD1 mRNA expression and activity is essential for the induction of human adipogenesis. (ox.ac.uk)
- Our previous data, illustrating decreased HA production during human adipogenesis, suggested an inhibitory role. (cardiff.ac.uk)
- In human subjects, circulating HA correlated negatively with BMI and triglycerides (r = −0.396 (p = 0.002), r = −0.269 (p = 0.038), respectively), confirming an inhibitory role of HA in human adipogenesis. (cardiff.ac.uk)
Induces adipogenesis1
- Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. (aspetjournals.org)
Inhibit adipogenesis1
- AD did not inhibit adipogenesis at 10 μM concentration and also did not inhibitmyogenesis at 10 μM concentration. (scirp.org)
Lipid1
- Placental DNA methylation was measured for 12 target candidate genes that are related to fetal growth, adipogenesis, lipid and energy metabolism, or long interspersed nuclear elements. (elsevier.com)
Early phase of adipogenesis2
- These results challenge the existing model on transcriptional regulation in the early phase of adipogenesis and highlight the need of studying adipogenesis in vivo. (nih.gov)
- We also show that while endogenous Krox20 and KLF4 are transiently induced in the early phase of adipogenesis in culture, they are dispensable for adipogenesis in vitro and in vivo. (nih.gov)
Master regulator of adipogenesis3
- High throughput screening and binding assays have identified TBBPA as an agonist for human peroxisome proliferator-activated receptor gamma (PPARγ), the master regulator of adipogenesis. (nih.gov)
- MED12 knockdown has produced similar results, but a potential interaction between MED12 and the master regulator of adipogenesis, PPARG, has been revealed through the application of delayed knockdown assays. (latech.edu)
- PPARγ is a ligand-activated transcription factor (TF) and a master regulator of adipogenesis. (nih.gov)
Genes2
- RNA sequencing analysis revealed decreased enrichment of genes associated with adipogenesis in inguinal white adipose of FMRKO mice. (endocrine.org)
- H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis ( EMBO J 2013 ) while H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis ( PNAS 2010 ). (nih.gov)
Inhibits adipogenesis via1
- Calreticulin inhibits adipogenesis via a negative feedback mechanism whereby the expression of calreticulin is initially up-regulated by peroxisome proliferator-activated receptor γ (PPARγ). (rupress.org)
Process called adipogenesis2
- When hair growth begins, the fat layer expands in a process called adipogenesis. (nextbigfuture.com)
- FKBP51 expression in adipose tissue increases with the formation of new fat cells, a process called adipogenesis. (uky.edu)
PPAR6
- Additionally, we observed that DIM treatment (40 and 60 μM), but not I3C treatment, significantly inhibited MDI-induced adipogenesis by reducing the levels of several adipogenic proteins such as PPAR-γ and C/EBPα. (nih.gov)
- MDI: adipogenesis positive control, ROSI: rosiglitazone and MDI (PPARγ agonist positive control). (nih.gov)
- H3K4 methyltransferases MLL3/4 and associated PTIP directly control the induction of principal adipogenic TFs PPARγ and C/EBPα and are essential for adipogenesis ( Cell Metab 2009 , eLife 2013 ). (nih.gov)
- PPARγ: a circadian transcription factor in adipogenesis and osteogenesis. (nih.gov)
- Activation of transcription factor PPARγ plays an essential role in the adipogenesis. (scielo.org)
- Certain fatty acids are PPARγ ligands and can control adipogenesis. (scielo.org)
Regulator1
- 2013). Rap1 is a major telomere binding protein that also acts as a transcriptional regulator controlling adipogenesis. (mskcc.org)
PPARg2
- While PPARg and C/EBPa/b/d have been shown to be critical for adipogenesis in mice, it has remained unclear whether endogenous GR, KLF4 and Krox20 are also required for adipogenesis in vivo. (nih.gov)
- The induction of PPARg is required for adipogenesis, and this is regulated by a coordination of hormonal, epigenomic, and transcriptional factors that define a novel early stage of adipognesis. (nih.gov)
Function and adipogenesis2
Adipose tissue4
- Obesity is caused by an increase in adipose tissue mass, which results from the multiplication of fat cells through adipogenesis and the increased deposition of cytoplasmic triglycerides [ 2 ]. (springer.com)
- Epigenomic mechanisms play critical roles in adipose tissue development (adipogenesis, reviewed in MCB 2019 ) and expansion. (nih.gov)
- 2020) Sex differences in human adipose tissue gene expression and genetic regulation involve adipogenesis. (news-medical.net)
- 3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis. (ki.se)
Vivo3
- Thus, the in-vitro results of AD on adipogenesis correlated with the in-vivo results of AD on fat-mass from clinical trials and suggested a possible difference in biological action between weak androgens (AD, DHEA) and strong androgens (T, DHT) on adipogenesis. (scirp.org)
- Core fucosylation was also significantly increased during in vivo adipogenesis but did not correlate with an increase in Fut8 gene transcript. (edu.au)
- Here, we hypothesized that supplementation with the insulin inhibitor and mitochondrial uncoupler, Tyrphostin (T-AG17), in vitro and in vivo inhibits adipogenesis and adipocyte hypertrophy. (uanl.mx)
Insulin Resistance2
- Further studies are needed to delineate the underlying regulation of maximal triglyceride storage capacity, adipogenesis, and mediators of insulin resistance, and the unique biological properties of the small, as compared with large, adipose cells. (grantome.com)
- Hypoxia affects several biological functions including adipogenesis, inflammation, insulin resistance and metabolism affecting the overall degree of adiposity. (endocrine-abstracts.org)
Vitro adipogenesis1
- Here, we report upregulated Mecp2 in white adipose tissues (WAT) of obese humans, as well as in obese mice and during in vitro adipogenesis. (diabetesjournals.org)
Controls adipogenesis1
- Cathepsin L activity controls adipogenesis and glucose tolerance. (harvard.edu)
Myogenesis2
- Addition of bicalutamide, an androgen receptor (AR) antagonist decreased myogenesis and increased adipogenesis, indicating that the effect of AD was mediated through AR. (scirp.org)
- The epigenomic reader Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis. (nih.gov)
Inhibition1
- Xanthohumol also regulates various metabolic processes including the inhibition of triglyceride formation, atherosclerotic plaque and adipogenesis. (sigmaaldrich.com)
MRNA1
- In addition, fat depots responded differently to estrogen withdrawal (e.g., selective mRNA enhancement of adipogenesis markers in subcutaneous and of inflammation in visceral fat pads) and replacement challenges. (inserm.fr)
Induction2
20191
- 2019. Cell shape alteration during adipogenesis is associated with coordinated matrix cues. (tau.ac.il)
Inhibitor1
- Blocking adipogenesis with a novel and specific 11beta-HSD1 inhibitor may represent a novel approach to treat obesity in patients with MS. (ox.ac.uk)
Transcription2
- It also decreased adipogenesis-related transcription factor expression, including peroxisome proliferator-activated receptor and CCAAT/enhancer-binding protein. (hindawi.com)
- The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis. (gusto.sg)
Fibroblasts1
- They observed reactive adipogenesis in some types of fibroblasts. (nih.gov)
Fetal2
- We have shown that maternal obesity increases fetal intramuscular adipogenesis at mid-gestation. (uthscsa.edu)
- Overexpression of let-7g decreased expression of inflammatory cytokines.Conclusion:Fetal muscle miRNA expression was altered due to maternal obesity, and let-7g downregulation may enhance intramuscular adipogenesis during fetal muscle development in the setting of maternal obesity. (uthscsa.edu)
Osteoblastogenesis1
- A chromosomal inversion within a quantitative trait locus has a major effect on adipogenesis and osteoblastogenesis. (jax.org)
Diet-induced obesity1
- We evaluated the safety of T-AG17 and its effects on physiological and molecular metabolic parameters including hormonal profile, glucose levels, adipogenesis and adipocyte hypertrophy in a diet-induced obesity model using C57BL/6 mice. (uanl.mx)
Bone1
- However, the efficacy of the technique is controversial, and it has little effects on inhibiting bone marrow adipogenesis and fat cell hypertrophy [ 8 ]. (biomedcentral.com)
Pathways2
- Although molecular pathways governing adipogenesis are well delineated, the structure of the nuclear lamina and nuclear-cytoskeleton junction in this process are not. (maastrichtuniversity.nl)
- This study will describe the signaling pathways of adipogenesis and marbling by transcriptome sequencing of steers that received vitamin A during the neonatal phase as a strategy to increase IMF deposition. (fapesp.br)