Adhesiveness: A property of the surface of an object that makes it stick to another surface.Cell Adhesion: Adherence of cells to surfaces or to other cells.Platelet Adhesiveness: The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.Cell Aggregation: The phenomenon by which dissociated cells intermixed in vitro tend to group themselves with cells of their own type.Cell Adhesion Molecules: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Intercellular Adhesion Molecule-1: A cell-surface ligand involved in leukocyte adhesion and inflammation. Its production is induced by gamma-interferon and it is required for neutrophil migration into inflamed tissue.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Vascular Cell Adhesion Molecule-1: Cytokine-induced cell adhesion molecule present on activated endothelial cells, tissue macrophages, dendritic cells, bone marrow fibroblasts, myoblasts, and myotubes. It is important for the recruitment of leukocytes to sites of inflammation. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, p154)Bacterial Adhesion: Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Leukocyte Rolling: Movement of tethered, spherical LEUKOCYTES along the endothelial surface of the microvasculature. The tethering and rolling involves interaction with SELECTINS and other adhesion molecules in both the ENDOTHELIUM and leukocyte. The rolling leukocyte then becomes activated by CHEMOKINES, flattens out, and firmly adheres to the endothelial surface in preparation for transmigration through the interendothelial cell junction. (From Abbas, Cellular and Molecular Immunology, 3rd ed)Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.N-Formylmethionine: Effective in the initiation of protein synthesis. The initiating methionine residue enters the ribosome as N-formylmethionyl tRNA. This process occurs in Escherichia coli and other bacteria as well as in the mitochondria of eucaryotic cells.Leukocytes: White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Lymphocyte Function-Associated Antigen-1: An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Microscopy, Electron, Scanning: Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.E-Selectin: Cell adhesion molecule and CD antigen that mediates neutrophil, monocyte, and memory T-cell adhesion to cytokine-activated endothelial cells. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family.Integrins: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Antigens, CD18: Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.Blood Cell Count: The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.Surface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Monocytes: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.Integrin alpha4beta1: Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Vinculin: A cytoskeletal protein associated with cell-cell and cell-matrix interactions. The amino acid sequence of human vinculin has been determined. The protein consists of 1066 amino acid residues and its gene has been assigned to chromosome 10.Cytoskeleton: The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.Intercellular Junctions: Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)Selectins: Transmembrane proteins consisting of a lectin-like domain, an epidermal growth factor-like domain, and a variable number of domains that are homologous to complement regulatory proteins. They are important cell adhesion molecules which help LEUKOCYTES attach to VASCULAR ENDOTHELIUM.Fibronectins: Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.Blood Coagulation Tests: Laboratory tests for evaluating the individual's clotting mechanism.Glass: Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.Adenine NucleotidesEpoxy Resins: Polymeric resins derived from OXIRANES and characterized by strength and thermosetting properties. Epoxy resins are often used as dental materials.Umbilical Veins: Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.P-Selectin: Cell adhesion molecule and CD antigen that mediates the adhesion of neutrophils and monocytes to activated platelets and endothelial cells.Chemotaxis, Leukocyte: The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.Limb Buds: Distinct regions of mesenchymal outgrowth at both flanks of an embryo during the SOMITE period. Limb buds, covered by ECTODERM, give rise to forelimb, hindlimb, and eventual functional limb structures. Limb bud cultures are used to study CELL DIFFERENTIATION; ORGANOGENESIS; and MORPHOGENESIS.Eye Enucleation: The surgical removal of the eyeball leaving the eye muscles and remaining orbital contents intact.Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.Calreticulin: A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.Desmosomes: A type of junction that attaches one cell to its neighbor. One of a number of differentiated regions which occur, for example, where the cytoplasmic membranes of adjacent epithelial cells are closely apposed. It consists of a circular region of each membrane together with associated intracellular microfilaments and an intercellular material which may include, for example, mucopolysaccharides. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990; Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Endothelium: A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.Pigment Epithelium of Eye: The layer of pigment-containing epithelial cells in the RETINA; the CILIARY BODY; and the IRIS in the eye.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Macrophage-1 Antigen: An adhesion-promoting leukocyte surface membrane heterodimer. The alpha subunit consists of the CD11b ANTIGEN and the beta subunit the CD18 ANTIGEN. The antigen, which is an integrin, functions both as a receptor for complement 3 and in cell-cell and cell-substrate adhesive interactions.Fimbriae, Bacterial: Thin, hairlike appendages, 1 to 20 microns in length and often occurring in large numbers, present on the cells of gram-negative bacteria, particularly Enterobacteriaceae and Neisseria. Unlike flagella, they do not possess motility, but being protein (pilin) in nature, they possess antigenic and hemagglutinating properties. They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). Bacterial fimbriae refer to common pili, to be distinguished from the preferred use of "pili", which is confined to sex pili (PILI, SEX).Methods: A series of steps taken in order to conduct research.Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.Matched-Pair Analysis: A type of analysis in which subjects in a study group and a comparison group are made comparable with respect to extraneous factors by individually pairing study subjects with the comparison group subjects (e.g., age-matched controls).Antigens, CD11: A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95.Colchicine: A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).Laminin: Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.Antigens, CD29: Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Chick Embryo: The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.Chemotactic Factors: Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult.Microscopy, Phase-Contrast: A form of interference microscopy in which variations of the refracting index in the object are converted into variations of intensity in the image. This is achieved by the action of a phase plate.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Rheology: The study of the deformation and flow of matter, usually liquids or fluids, and of the plastic flow of solids. The concept covers consistency, dilatancy, liquefaction, resistance to flow, shearing, thixotrophy, and VISCOSITY.Materials Testing: The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.Hemagglutination: The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).N-Formylmethionine Leucyl-Phenylalanine: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.L-Selectin: Cell adhesion molecule and CD antigen that serves as a homing receptor for lymphocytes to lymph node high endothelial venules.Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.Platelet Aggregation: The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.Dental Bonding: An adhesion procedure for orthodontic attachments, such as plastic DENTAL CROWNS. This process usually includes the application of an adhesive material (DENTAL CEMENTS) and letting it harden in-place by light or chemical curing.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Cell Size: The quantity of volume or surface area of CELLS.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Adhesins, Bacterial: Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Endothelial Cells: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.Blood Coagulation: The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.ZymosanCell Communication: Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.Methacrylates: Acrylic acids or acrylates which are substituted in the C-2 position with a methyl group.Embryo Implantation: Endometrial implantation of EMBRYO, MAMMALIAN at the BLASTOCYST stage.Cytoskeletal Proteins: Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.Fibrinolysis: The natural enzymatic dissolution of FIBRIN.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Plasma: The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Tensile Strength: The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001)Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Morphogenesis: The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Retina: The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.Stress, Mechanical: A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Leukocytes, Mononuclear: Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.Chemotaxis: The movement of cells or organisms toward or away from a substance in response to its concentration gradient.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Oligopeptides: Peptides composed of between two and twelve amino acids.Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Magnesium: A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.Extracellular Matrix Proteins: Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).Trypsin: A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Cytoplasm: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Kinetics: The rate dynamics in chemical or physical systems.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.beta Catenin: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.PolysaccharidesClone Cells: A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Arginine: An essential amino acid that is physiologically active in the L-form.Interleukin-1: A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Cell Line, Tumor: A cell line derived from cultured tumor cells.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Culture Media: Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.Aorta: The main trunk of the systemic arteries.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Protein Kinase C: An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.Mice, Inbred BALB CCell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Mice, Inbred C57BL
(1/1085) The forward rate of binding of surface-tethered reactants: effect of relative motion between two surfaces.

The reaction of molecules confined to two dimensions is of interest in cell adhesion, specifically for the reaction between cell surface receptors and substrate-bound ligand. We have developed a model to describe the overall rate of reaction of species that are bound to surfaces under relative motion, such that the Peclet number is order one or greater. The encounter rate between reactive species is calculated from solution of the two-dimensional convection-diffusion equation. The probability that each encounter will lead to binding depends on the intrinsic rate of reaction and the encounter duration. The encounter duration is obtained from the theory of first passage times. We find that the binding rate increases with relative velocity between the two surfaces, then reaches a plateau. This plateau indicates that the increase in the encounter rate is counterbalanced by the decrease in the encounter duration as the relative velocity increases. The binding rate is fully described by two dimensionless parameters, the Peclet number and the Damkohler number. We use this model to explain data from the cell adhesion literature by incorporating these rate laws into "adhesive dynamics" simulations to model the binding of a cell to a surface under flow. Leukocytes are known to display a "shear threshold effect" when binding selectin-coated surfaces under shear flow, defined as an increase in bind rate with shear; this effect, as calculated here, is due to an increase in collisions between receptor and ligand with increasing shear. The model can be used to explain other published data on the effect of wall shear rate on the binding of cells to surfaces, specifically the mild decrease in binding within a fixed area with increasing shear rate.  (+info)

(2/1085) Adhesion energy of receptor-mediated interaction measured by elastic deformation.

We investigated the role of receptor binding affinity in surface adhesion. A sensitive technique was developed to measure the surface energy of receptor-mediated adhesion. The experimental system involved a functionalized elastic agarose bead resting on a functionalized glass coverslip. Attractive intersurface forces pulled the two surfaces together, deforming the bead to produce an enlarged contact area. The Johnson-Kendall-Roberts (JKR) model was used to relate the surface energy of the interaction to the elasticity of the bead and the area of contact. The surface energies for different combinations of modified surfaces in solution were obtained from reflection interference contrast microscopy (RICM) measurements of the contact area formed by the bead and the coverslip. Studies with surfaces functionalized with ligand-receptor pairs showed that the relationship between surface energy and the association constant of the ligand binding has two regimes. At low binding affinity, surface energy increased linearly with the association constant, while surface energy increased logarithmically with the association constant in the high affinity regime.  (+info)

(3/1085) Steric effects of N-acyl group in O-methacryloyl-N-acyl tyrosines on the adhesiveness of unetched human dentin.

We have prepared various O-methacryloyl-N-acyl tyrosines (MAATY) to reveal the relationship between molecular structure near carboxylic acid and adhesive strength of MAATY-HEMA type adhesive resin to unetched dentin. In this study, we attempted to change the steric hindrance effect without changing the HLB value, i.e., introducing an iso-acyl group instead of n-acyl group into MAATY. O-methacryloyl-N-ethylbutyryl tyrosine (MIHTY) showed significantly lower adhesive strength when compared with O-methacryloyl-N-hexanoyl tyrosine even though both MAATY have the same HLB value. The possible explanation of the significantly different adhesive strength was that the 2-ethylbutyryl group in MIHTY was bulky, resulting in inhibition of the hydrogen bonding of the carboxylic group. The HLB value is independent of the steric effect of molecular structure, and thus the steric factor should be taken into consideration for the explanation of different adhesive strengths within the adhesive monomers having the same HLB value but different molecular structures.  (+info)

(4/1085) Adhesion of adhesive resin to dental precious metal alloys. Part I. New precious metal alloys with base metals for resin bonding.

New dental precious metal alloys for resin bonding without alloy surface modification were developed by adding base metals (In, Zn, or Sn). Before this, binary alloys of Au, Ag, Cu, or Pd containing In, Zn, or Sn were studied for water durability and bonding strength with 4-META resin. The adhesion ability of the binary alloys was improved by adding In equivalent to 15% of Au content, Zn equivalent to 20% of Ag content, and In, Zn, or Sn equivalent to 5% of Cu content. There was no addition effect of the base metals on Pd, however 15% of In addition improved adhesion with Pd-based alloys containing equi-atomic % of Cu and Pd. The alloy surfaces were analyzed by XPS and showed that oxides such as In2O3, ZnO, or SnO play an important role in improving the adhesive ability of the alloys.  (+info)

(5/1085) Adhesion of adhesive resin to dental precious metal alloys. Part II. The relationship between surface structure of Au-In alloys and adhesive ability with 4-META resin.

Adhesion of 4-META to Au-In alloy was improved by adding In equivalent to .15% of Au content. On the basis of the results of Au-In alloys analyzed by XPS, the present study investigated the reason why adhesion of the Au-In alloy was improved. The O 1s spectrum could be separated into three oxygen chemical states, In2O3, chemisorbed H2O, and physisorbed H2O. The amount of chemisorbed H2O decreased remarkably with increasing amount of In. It is considered that the poor adhesive ability of the pure gold and alloys containing only small amounts of In was due to the chemisorbed H2O molecules and insufficient indium oxide on the alloy surface. It was established that excellent adhesion requires an oxide with chemical affinity for 4-META to cover at least 50% of the alloy surface.  (+info)

(6/1085) Coating of extracorporeal circuit with heparin does not prevent sequestration of propofol in vitro.

Propofol is sequestered in extracorporeal circuits, but the factors responsible for the phenomenon are mostly unknown. We have compared two extracorporeal circuits (oxygenators, reservoirs and tubings) coated with heparin with two corresponding uncoated circuits for their capacity to sequester propofol in vitro. Three experiments were conducted with each circuit. The circuit was primed with a mixture of Ringer's acetate solution and whole blood, and the study conditions (pump flow, temperature, pH) were standardized. Propofol was added to the solution to achieve a concentration of 2 micrograms ml-1. These studies were followed with concentrations of 10- and 100-fold to assess possible saturation of propofol binding. Serial samples were obtained from the circulating solution for measurement of propofol concentration. Propofol concentrations decreased to 22-32% of the initial predicted concentration of 2 micrograms ml-1 in the circuits (no significant difference between circuits). With greater concentrations, the circuits did not become saturated with propofol, even with the highest predicted concentration of 200 micrograms ml-1. We conclude that propofol was sequestered in extracorporeal circuits in vitro, irrespective of coating the circuit with heparin.  (+info)

(7/1085) An ex vivo investigation into the bond strength of orthodontic brackets and adhesive systems.

The aim of this study was to compare the shear bond strength of Adhesive Precoated Brackets (APC) with that of two types of uncoated bracket bases, Straight-Wire and Dyna-Lock. Two types of orthodontic adhesives were used, Transbond XT and Right-On. Three different curing times were evaluated with the APC brackets in order to find the best. Adhesive remnants on the enamel surface following debond were evaluated using the Adhesive Remnant Index (Artun and Bergland, 1984). Bond strengths ranged from 11.00 to 22.08 MPa. For both types of brackets Transbond produced a significant increase in bond strength compared to Right-On. The Dyna-Lock/Right-On combination produced the poorest results. APC brackets cured for 40 s had similar bond strengths to uncoated brackets fixed by means of Transbond. Overall, 79 per cent of specimens had less than half the tooth surface covered with adhesive following debond. Significantly more adhesive remained on tooth surfaces following debond of the Straight-Wire/Right-On group than any other bracket/adhesive combination. Bond strengths were higher with light-cured Transbond than with chemically-cured Right-On. When Transbond is used in association with APC brackets a 40-second cure time is recommended.  (+info)

(8/1085) The influence of epitope availability on atomic-force microscope studies of antigen-antibody interactions.

The ability of the atomic-force microscope (AFM) to detect interaction forces between individual biological molecules has recently been demonstrated. In this study, force measurements have been obtained between AFM probes functionalized with the beta-subunit of human chorionic gonadotrophin (betahCG) and surfaces functionalized with anti-betahCG antibody. A comparison of the obtained results with previous anti-ferritin antibody-binding data identifies differences when the antigen molecule expresses only a single epitope (betahCG), rather than multiple epitopes (ferritin), for the monoclonal antibodies employed. Specifically, the probability of observing probe-sample adhesion is found to be higher when the antigen expresses multiple epitopes. However, the periodic force observed in the adhesive-force distribution, due to the rupture of single antigen-antibody interactions, is found to be larger and more clearly observed for the mono-epitopic system. Hence, these findings indicate the potential of the AFM to distinguish between multivalent and monovalent antibody-antigen interactions, and demonstrate the influence of the number of expressed epitopes upon such binding studies.  (+info)

*  Platelet adhesiveness
... is the adhesion of platelets to other structures. It can be contrasted with platelet aggregation, which ... May 2004). "Assessment of platelet adhesiveness and aggregation in mild acute pancreatitis using the PFA-100 system". JOP. 5 (3 ... Platelet membrane glycoprotein Platelet adhesiveness at the US National Library of Medicine Medical Subject Headings (MeSH) ...
*  Occludin
Van Itallie CM, Anderson JM (1997). "Occludin confers adhesiveness when expressed in fibroblasts". J. Cell Sci. 110 (9): 1113- ...
*  Weissella cibaria
"Coaggregation ability ofWeissella cibariaisolates withFusobacterium nucleatumand their adhesiveness to epithelial cells". FEMS ...
*  Seed trap
Heat and light intensities can also cause sticky traps to loos their adhesiveness. Pollen traps are used to measure production ...
*  Anaerolinea
Xia, Yu; Wang, Yubo; Wang, Yi; Chin, Francis Y. L.; Zhang, Tong (23 May 2016). "Cellular adhesiveness and cellulolytic capacity ...
*  N-Formylmethionine-leucyl-phenylalanine
... and foreign surface adhesiveness of human leukocytes". The American Journal of Pathology. 90 (3): 537-50. PMC 2018255 . PMID ... these responses result from an increase in neutrophil adhesiveness to each other and/or vascular endothelium); the release (see ...
*  Helge Stormorken
Berg, KJ; Skaga, E; Skjaeggestad, O; Stormorken, H (13 November 1965). "Effect of linseed oil on platelet adhesiveness and ...
*  1-Vinylimidazole
It is also used for the functionalization of polymer surfaces by UV-induced grafting to improve wettability and adhesiveness. 1 ...
*  Alberger process
... high solubility and good adhesiveness. The extremely low bulk density makes the salt highly prized in the fast-food industry ...
*  FERMT3
"Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions". Blood. 114 (11 ...
*  Clue cell
Scott TG, Smyth CJ, Keane CT (February 1987). "In vitro adhesiveness and biotype of Gardnerella vaginalis strains in relation ...
*  EGF-like domain
... and L-selectin increases adhesiveness and shear resistance under hydrodynamic force". Nat Immunol. 7 (8): 883-9. doi:10.1038/ ...
*  Smart polymer
... s may change conformation, adhesiveness or water retention properties, due to slight changes in pH, ionic strength ...
*  Thermal interface material
... thicker bond lines than the thermal grease as it cures while still allowing an easy disassembly thanks to limited adhesiveness ...
*  CYTH1
The CYTH1 is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the ...
*  Beta-catenin
... a cause of loss of intercellular adhesiveness in human cancer cell lines". Cancer Research. 54 (23): 6282-7. PMID 7954478. ...
*  Catenin alpha-1
... a cause of loss of intercellular adhesiveness in human cancer cell lines". Cancer Res. 54 (23): 6282-7. PMID 7954478. Roe S, ... a cause of loss of intercellular adhesiveness in human cancer cell lines". Cancer Res. 54 (23): 6282-7. PMID 7954478. McPherson ...
*  CDH1 (gene)
... a cause of loss of intercellular adhesiveness in human cancer cell lines". Cancer Res. 54 (23): 6282-7. PMID 7954478. Hazan RB ...
*  Dextran
... increasing their electronegativity and thus reducing erythrocyte aggregation and platelet adhesiveness. Dextrans also reduce ...
*  Inkometer
An inkometer is a specialized measuring instrument used by the printing industry to measure the "tack" (adhesiveness) of an ink ...
*  List of MeSH codes (G09)
... platelet adhesiveness MeSH G09.188.261.560.600.640 --- platelet aggregation MeSH G09.188.261.780 --- phagocytosis MeSH G09.330. ... platelet adhesiveness MeSH G09.188.250.680 --- prothrombin time MeSH G09.188.250.760 --- reticulocytosis MeSH G09.188.250.840 ...
*  Vulcanization
... it might divest the gum of its native adhesiveness throughout, which would make it better than the native gum. Upon further ...
*  Human genetic resistance to malaria
... on the infected red blood cell surface and the modified display of malaria surface proteins reduces parasite adhesiveness ( ...
*  5-Hydroxyeicosatetraenoic acid
... and increases in their cell surface adhesiveness as indicated by their aggregation to each other. Since a previously discovered ...
*  The Constitution of Man
Adhesiveness, Comrativeness, Destructiveness, Constructiveness, Acquisitiveness, Secretiveness) Genus II. Sentiments Common to ...
Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery devices. The bioadhesive properties of a polymer are enhanced by incorporating a anhydrideoligome into the polymer to enhance the ability of the polymer to adhere to a tissue surface such as a mucosal membrane. Anhydrideoligomes which enhance the bioadhesive properties of a polymer include water-insoluble anhydrideoligomes such as water-insoluble metal oxides, including oxides of calcium, iron, copper and zinc. The anhydrideoligomes can be incorporated within a wide range of polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, metal oxides can be incorporated within polymers used to form or coat drug delivery devices, such as microspheres, which contain a drug or diagnostic agent. The metal oxides can be provided in the form of a fine dispersion of particles on the surface of a polymer that coats or forms the devices, which enhances the ability
The remarkable underwater adhesion strategy employed by mussels has inspired bioadhesives that have demonstrated promise in connective tissue repair, wound closure, and local delivery of therapeutic cells and drugs. While the pH of oxygenated blood and internal tissues is typically around 7.4, skin and tumor tissues are significantly more acidic. Additionally, blood loss during surgery and ischemia can lead to dysoxia, which lowers pH levels of internal tissues and organs. Using 4-armed PEG end-capped with dopamine (PEG-D) as a model adhesive polymer, the effect of pH on the rate of intermolecular cross-linking and adhesion to biological substrates of catechol-containing adhesives was determined. Adhesive formulated at an acidic pH (pH 5.7-6.7) demonstrated reduced curing rate, mechanical properties and adhesive performance to pericardium tissues. Although a faster curing rate was observed at pH 8, these adhesives also demonstrated reduced mechanical and bioadhesive properties when compared to ...
All information about the latest scientific publications of the Clínica Universidad de Navarra. Bioadhesive properties and biodistribution of cyclodextrin-poly(anhydride) nanoparticles
C. albicans hyphae were virtually divided into a "tip" (the growing and therefore youngest part of the hyphae), a "middle" and a so-called "head" region (the yeast cell from which germination started). Adhesion forces between S. aureus NCTC8325-4GFP and the different regions of C. albicans SC5314 hyphae were measured using atomic force microscopy. Strong adhesion forces were found at the tip and middle regions of C. albicans hyphae (−4.1 nN and −4.0 nN, respectively), while much smaller adhesion forces were measured at the head region (−0.3 nN). Adhesion forces exerted by the head region were comparable with the forces arising from budding yeast cells (−0.5 nN). A similar regional dependence of the staphylococcal adhesion forces was found for the clinical isolate involved in this study, C. albicans MB1 ...
Van der Waals forces: Van der Waals forces, relatively weak electric forces that attract neutral molecules to one another in gases, in liquefied and solidified gases, and in almost all organic liquids and solids. The forces are named for the Dutch physicist Johannes Diderik van der Waals, who in 1873 first postulated
Tissue engineering is a multidisciplinary field that aims to repair or regenerate lost or damaged tissues and organs in the body. For the repair of certain load-bearing parts of the body, success of a tissue regeneration strategy can be dependent on scaffold adhesion or integration with the surrounding host tissue to prevent dislocation. One such area is the regeneration of the intervertebral disc (IVD). The objective of this work is to generate a bioadhesive polymer that, in addition to bonding with tissue, can support encapsulated cell survival post-adhesion. Thermosensitive poly(N-isopropylacrylamide) (PNIPAAm) was grafted with chondroitin sulfate (CS) (PNIPAAm-g-CS) and blended with aldehyde-modified CS to achieve covalent adhesion upon contact with tissue. Extracellular matrix (ECM) loaded lipid vesicles (liposomes) were incorporated into the copolymer for enhanced cellular biocompatibility. The bioadhesive strength was evaluated in contact with porcine ear cartilage. Additionally, the cytotoxicity
We found no difference in the adhesive force or the motion of clinging digits between before and after death treatments (figure 2b,f). Although previous research and anecdotes have shown that some adhesion can still occur after death in geckos [15-17], our controlled experiments are the first to show that dead animals maintain the ability to adhere with the same force as living animals. These results refute the hypothesis that actions by a living animal, such as muscle recruitment or neural activity, are required for gecko feet to generate our high measured forces.. The high variation in adhesive force among trials on both living and dead geckos is surprising. Despite the controlled pulling force applied by our pulling device, peak adhesive force spanned a range that was 19.9 times the mean body weight. When averaged among individuals, the mean coefficients of variation for adhesive force before and after death were 0.33 and 0.36, respectively. After pooling alive and dead trials, a multiple ...
By forcing a wetting transition in the setal mats, we also observed a significant drop in adhesion across steps and treatments when compared with the control treatment carried out with non-wetted (Cassie regime) setal mats. In the fourth step, mean shear adhesive force of all three wetted treatments (SD, SM and SW) did not differ and was significantly lower (mean of three treatments 0.86±0.09 N) than the control (17.96±3.42 N). There may be several reasons for this finding. Wetting of the toe pads forced a transition that compromised the innate superhydrophobicity of the adhesive setal mats (Pesika et al., 2009), consequently allowing water to fill the mats. Although we let the toe pads drip-dry after the soaking treatment, we often observed small pools of water on the glass substrate after the gecko had taken a step. In many cases the small pools of water clearly represented the lamellar area by mimicking the macroscopic patterning of the toe pad. This is not surprising as the increased ...
Downloadable! To investigate the banking sector integration across euro area countries in terms of loan interest rate stickiness, we estimate structural loan rate curves for 12 euro area countries using time-varying regressions with stochastic volatility. Our results show that the loan rates are sticky to a policy interest rate in all countries for all loan maturities, the degree of stickiness differs across the countries, and the degree of difference is more prominent for longer loan maturities. For short-term loans, the loan rate stickiness decreases and for intermediate- and long-term loans the loan rate stickiness converge to average levels during the sample periods. Banking integration in the euro area is not yet complete, but the degree of heterogeneity in the loan rate stickiness decreases.
Cohesive and adhesive forces are associated with bulk (or macroscopic) properties and hence the terms are not applicable to discussion of atomic and molecular properties. When a liquid comes into …
The sticking of product material to injection molding tools is a serious problem, which reduces productivity and reliability. Depositing alloy nitride coatings (TiN, ZrN, CrN, and TiAlCrN) using closed field unbalanced magnetron sputter ion plating and electrodeposition of chromium, and characterizing their surface free energies in the temperature range 20-120°C have led to the development of a non-sticking (with a low surface free energy) coating system for semiconductor IC packaging molding dies. The contact angles of water, diiodomethane and ethylene glycol on the coated surfaces were measured at temperatures in the range 20-120°C using a Dataphysics OCA-20 contact angle analyzer. The surface free energy of the coatings and their components (dispersion and polar) were calculated using the Owens-Wendt geometric mean approach. The surface roughness of these coatings were investigated by atomic force microscopy (AFM). The adhesion force of these coatings were measured using direct tensile ...
Article Modeling study of the effects of the coagulation kernel with van der Waals forces and turbulence on the particle size distribution. In this study, variations in the size distributions due to different assumptions for the coagulation kernel ar...
Calculation of surface free energy (SFE) from contact angle results, measurement of contact angles on solids yields data that reflect the thermodynamics of a liquid/solid interaction.
The original concept of bioadhesive polymers as platforms for oral controlled drug delivery was to use these polymers to control and to prolong the GI transit of oral controlled delivery systems for all kinds of drugs. Several in vitro and ex vivo methods to test the bioadhesive properties of polymers and/or of coated microparticles have been described. Whereas bioadhesion has found interesting applications for other routes of administration (buccal, nasal, rectal and vaginal), it now seems that the controlling approach of GI transit has been abandoned before having shown any significant clinical outcome. According to in vivo results obtained in animals and in humans, it does not seem that mucoadhesive polymers are able to control and slow down significantly the GI transit of solid delivery systems. Attention should be paid to possible occurrence of local ulcerous side effects due to the intimate contact of the system with mucosa for prolonged periods of time. As an example, oesophageal ...
Corresponding to previous reports (Babos, 1964), each leg terminated with an ambulacrum (pretarsus), which was composed of an elongated apotele bearing long, paired, rod-shaped, curved claws (Figs 2E-G and 3A,E).. They appeared lunate and transparent, having an average thickness of 15.1±1.31 µm (n=5) and a length of 135.2±17.58 µm (n=5). A thin outer cuticular layer surrounded the claw interior, which was completely filled with an amorphous material (see below).. They tapered into a mean claw tip diameter of 1.2±0.36 µm (n=10). The claw base was slightly broadened, reaching about 20.1±1.62 µm in width (n=5).. The mean diameter of a circle fitting the claw curvature measured 54.7±8.08 µm (n=10). Between the claws, a foldable pad arose (Figs 2E-G and 3A-D). The fluorescence microscopy images (Fig. 2F,G) revealed the presence of resilin, an elastic protein, in the materials of pads, claws and membranous areas surrounding the tarsal-pretarsal articulation.. The pad was composed of three ...
Wholesale Non Adhesive Pad - Select 2018 high quality Wholesale Non Adhesive Pad products in best price from certified Chinese Non Woven Adhesive Bandage manufacturers, Adhesive Eye Pad suppliers, wholesalers and factory on Made-in-China.com
5x4.5Window Clings are made from a special paint that acts like static that clings to your window. These amazing clings are so darn cute that youll f
Self-Cleaning Glass, Tempered Glass, Clear Transparent Hot Sale. Product Introduction. Self-cleaning glass is made by sputtering a layer of transparent nanometer TiO2 photocatalytic film. When socalled light accelerant-TiO2 phtocatalytic fiilm meets UV ray, the organic substance and oleic acid adhensive to the surface of glass would be decomposed and the glass is cleaned.. Self-Cleaning Glass Product Features. Light-induced Water Affinity: When the contact angle between nanometer TiO2 film and water reaches 0-15, TiO2 demonstrates its water affinity. On one hand, it can isolate greasy dirt from surface of TiO2 film. On the other hand, greasy dirt can be easily lift up and flushed away by rain water. Because of the super water sffinity, the antifouling film would become an even water film when contact with water. In this case, the dust and dirt on the film will be floated up and falls along with water film formed by gravity. No water mark is left and effect of cleaning is ...
The science on display is the capillary action of the water - that is, how the flower drinks even without its roots. This ability draws water against the force of gravity up the stem and into the petals. It works because the water evaporating from the petals and leaves of the plant "pulls" water up the narrow tubes in the stem (the xylem) to replace that which is lost. The tubes need to be narrow so that the combination of the surface tension of the water (caused by cohesion in the water - how well it sticks to itself) and the adhesive forces between the water and the walls of the xylem are strong enough to lift the water against the force of gravity. The adhesive forces are proportional to the diameter of the tube, whilst the weight of the water is proportional to this diameter squared - hence a smaller diameter favours the adhesive forces ...
TY - JOUR. T1 - State of differentiation defines buccal epithelial cell affinity for cross-linking to Candida albicans Hwp1. AU - Ponniah, Gomathinayagam. AU - Rollenhagen, Christiane. AU - Bahn, Yong-Sun. AU - Staab, Janet F.. AU - Sundstrom, Paula. PY - 2007/9/1. Y1 - 2007/9/1. N2 - Candida albicans utilizes mammalian cell-associated transglutaminase (TGase) activity to adhere covalently to human buccal epithelial cells (BECs) through Hyphal Wall Protein 1. Little is known about the factors leading to the identity and appearance of Hwp1 binding partners on cells lining the oral cavity. The observation that BECs vary in their ability to attach to C. albicans germ tubes and to bind recombinant Hwp1 (rHwp1) suggested that differentiation may play a role in affinity for germ tube attachment. Individual BECs were characterized for differentiation status and rHwp1 binding. rHwp1 bound to the more terminally differentiated cells displaying SPR3 and keratin 13 but not to less differentiated cells with ...
... A description of the different factors affecting the hydraulic design of self-cleaning sewage tunnels with a free water surface is presented. It is found that the two most important problems involved are related to shear stress distribution and critical shear stress to secure self-cleaning. Based on a shear stress distribution normally assumed for open channels, a trapezoidal bottom shape is suggested. A value for critical shear stress to prevent settlement of sand in a mixture of wastewater is recommended, but design data are also included for alternative values of critical shear stress. Curves for determining shape, slope, and size of tunnels with known minimum and maximum rate of flow are given.
Researchers from Carnegie Melon University and Karlsruhe Institute of Technology have recently published an article in Journal of the Royal Society titled Staying Sticky: Contact Self-Cleaning of Gecko-Inspired Adhesives that presents the first gecko-inspired adhesive that matches both the attachment and self-cleaning properties of geckos foot on a smooth surface.. Using glass microspheres to simulate contamination the scientists created a synthetic gecko adhesive that could self-clean and recover lost adhesion. Real world applications of self-cleaning adhesives are reusable adhesive tapes, clothing, medical adhesives (bandages) and pick-and-place robots, among others.. Everyday challenge with traditional adhesives is that they loose their stickiness once contaminated. Geckos have been intriguing researchers for decades because of their unique and striking capability to maintain the stickiness of their toes through contact self-cleaning. They can travel up the walls and ceilings in a wide ...
How to Make Window Clings. Window clings are a fun way to decorate your windows for the holidays and other occasions. They are easy to peel off, rearrange, and replace. Unfortunately, store-bought ones dont come in a lot of designs, and...
Dry glue is an adhesion product based upon the adaptations of geckos feet that allow them to climb sheer surfaces such as vertical glass. Synthetic equivalents use carbon nanotubes as synthetic setae on reusable adhesive patches. A gecko can hang on a glass surface using only one toe. This ability is attributed to van der Waals force, although a more recent study suggests that water molecules of roughly monolayer thickness (present on virtually all natural surfaces) also play a role. In 2007, researchers from the University of Akron and Rensselaer Polytechnic Institute announced they had developed a form of flexible, reusable gecko tape using carbon nanotubes to create microscopic synthetic setae and spatulae capable of supporting a shear stress of 32 N/cm2, which is four times the strength of a geckos foot. In 2008 researchers from the University of Dayton reported a gecko glue capable of supporting 100N/cm2, ten times the strength generated by a geckos foot. The research also used carbon ...
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0089] Next, the ring frame and the backside of the semiconductor wafer are placed on the adhesive layer of the adhesive sheet according to the present invention, and then lightly pressed; thereby the semiconductor wafer is fixed. Next, in case the photopolymerization initiator (D) is blended to the adhesive layer, the energy ray is irradiated to the adhesive layer from the support side, and the reactive double bond group comprised in the coupling agent (C) and the unsaturated hydrocarbon group comprised in the heat curable resin (B) are reacted and cured; thereby the cohesion force of the adhesive layer is increased and the adhesive force between the adhesive layer and the support is made low. As for the energy ray being irradiated, the ultraviolet ray (UV), or the electron beam (EB) or so may be mentioned; and preferably the ultraviolet ray is used. Next, by using the cutting means such as the dicing saw or so, the above mentioned semiconductor wafer is cut and the semiconductor chip is ...
FABRICATION OF NOVEL NANOMATERIALS FOR POLYMER ELECTROLYTE MEMBRANE FUEL CELLS AND SELF-CLEANING APPLICATIONS , FABRICATION OF NOVEL NANOMATERIALS FOR POLYMER ELECTROLYTE MEMBRANE FUEL CELLS AND SELF-CLEANING APP... , کتابخانه دیجیتال دانشگاه آزاد اسلامی خوراسگان
Silk particles of different sizes and shapes were produced by milling and interactions with a series of polar and non-polar gaseous probes were investigated using an inverse gas chromatography technique. The surface energy of all silk materials is mostly determined by long range dispersive interactions such as van der Waals forces. The surface energy increases and surface energy heterogeneity widens after milling. All samples have amphoteric surfaces and the concentration of acidic groups increases after milling while the surfaces remain predominantly basic. We also examined powder compression and flow behaviours using a rheometer. Increase in surface energy, surface area, and static charges in sub-micron air jet milled particles contributed to their aggregation and therefore improved flowability. However they collapse under large pressures and form highly cohesive powder. Alkaline hydrolysis resulted in more crystalline fibres which on milling produced particles with higher density, lower ...
Description: The mechanical properties of the polymer-modified mortar are markedly improved over conventional cement mortar. We utilized recycled ABS in powder form and a polymer latex emulsion, polymer percentage ranges from 0 to 25 percent by polymer/cement ratio were investigated. The mechanical properties investigated were compression strength and adhesion strength. Compression strength effects did not have an impact on adhesion strength. Adhesion strength was calculated with pullout testing apparatus designed by the author. Results indicate that recycled ABS had a lower adhesive strength than the acrylic latex emulsion and the base mortar, but did increase in adhesive strength when mixed with maleic-anhydride. The adhesive strength was investigated for a Fiber Reinforced Polymer (FRP) made of an E glass fiber that is a continuous strand roving oriented and pre-tensioned longitudinally in an isopthalic polyester matrix material. The FRP rebar was compared to standard steel rebars, and ...
Advisor: Andrés J. García, PhD (Georgia Institute of Technology). Committee: Thomas H. Barker, PhD (Georgia Institute of Technology). Andrew P. Kowalczyk, PhD (Emory University). Susan N. Thomas, PhD (Georgia Institute of Technology). Cheng Zhu, PhD (Georgia Institute of Technology). Quantitative Analyses for Cadherin-Based Cell-Cell Adhesive Force. Cell adhesion is a critical determinant of tissue architecture and tissue organization. Cadherin proteins mediate cell-cell adhesion in a calcium-dependent manner. The functional roles for cadherin proteins early in development and in adults, as well as the multiple disease phenotypes resulting from cadherin dysregulation, underscore the importance of cadherin proteins. Quantitative assessment of cadherin interaction structure, force, and interaction dynamics is not yet completely understood because of lack of experimental platforms to study cadherin proteins as well as their often-conflicting roles in a tissue-specific manner. Adhesive force ...
Cu is an essential trace element but can be highly toxic to aquatic organisms at elevated concentrations. Greater use of CuO engineered nanoparticles (ENPs) may lead to increased concentrations of CuO ENPs in aquatic environments causing potential ecological injury. We examined the toxicity of CuO ENPs to marine mussels and the influence of mussels on the fate and transport of CuO ENPs. We exposed marine mussels to 1, 2, or 3 mg L−1 CuO ENPs for four weeks, and measured clearance rate, rejection, excretion and accumulation of Cu, and mussel shell growth. Mussel clearance rate was 48% less, and growth was 68% less, in mussels exposed to 3 mg L−1 than in control animals. Previous studies show 100% mortality at 1 mg Cu L−1, suggesting that CuO ENPs are much less toxic than ionic Cu, probably due to the slow dissolution rate of the ENPs. Mussels rejected and excreted CuO ENPs in biodeposits containing as much as 110 mg Cu g−1, suggesting the potential for magnification in sediments. Mussels exposed
This paper treats approximate solutions for a self-folding problem of carbon nanotubes. It has been observed in the molecular dynamics calculations (Buehler, Kong, Gao, and Huang, 2006, "Self-Folding and Unfolding of Carbon Nanotubes ," ASME J. Eng. Mater. Technol., 128, pp. 3-10) that a carbon nanotube with a large aspect ratio can self-fold due to the van der Waals force between the parts of the same carbon nanotube. The main issue in the self-folding problem is to determine the minimum threshold length of the carbon nanotube at which it becomes possible for the carbon nanotube to self-fold due to the van der Waals force. To the best of the authors knowledge, no exact solution for this problem has been obtained. In this paper, an approximate mathematical model based on the force method is constructed for the self-folding problem of carbon nanotubes, and is solved exactly as an elastica problem using elliptic functions. Additionally, three other mathematical models are constructed based on the ...
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When two surfaces approach each other in air, they attract. A phenomenon that is explained by van der Waals forces that affect molecules interaction. Without these - very weak - intermolecular forces, life as we know it would be impossible. They are responsible for a number of properties of molecular compounds, including crystal structures, condensing, melting and boiling points, surface tension, and densities. Intermolecular forces form molecules like enzymes, proteins, and DNA into the shapes required for biological activity. Van der Waals forces can also be repulsive, for instance when two surfaces approach each other in liquid: the same force which causes attraction in air (and which is responsible for so called stiction and adhesion) can be made repulsive by choosing the right combination of surface materials and intervening liquid. This force has the characteristic that it increases very rapidly with very small changes in separation when the surfaces are close to each other. Researchers now have
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The surface wettability of ACNTs is important for the development of hybrid nano-materials to perform various functions. However, as-grown ACNTs are super-hydrophobic due to the large proportions of air trapping. By using O2 plasma etching, the surface wettability of ACNTs can be tuned from super-hydrophobic to hydrophobic, and then to hydrophilic by adjusting the flow rate of O2 gas during the etching process. Moreover, it was found that the surface wettability could be recovered by removing the top part of O2 plasma treated CNTs. Combining with laser-pruning technology, ACNT films with different kinds of patterns can be produced. Thus, CNT films with patterns of controlled wettability were produced and these can act as templates for the selective assembly of various nano-particles such as PS particles, CdTe quantum dots, and fluorescent particles ...
We have distinguished five TNF-alpha-inducible cell adhesion mechanisms on microvasculature-derived endothelioma cells of the mouse which mediate the binding of different types of leukocytes. Three of these mechanisms could be identified as the mouse homologs of ICAM-1, VCAM-1, and E-selectin, of which the latter was defined by the novel mAb 21KC10. The fourth TNF-alpha-inducible cell adhesion mechanism was blocked by antibodies specific for mouse P-selectin. We have recently shown that TNF-alpha stimulates the synthesis of P-selectin in mouse endothelioma cells (A. Weller, S. Isenmann, D. Vestweber. 1992. J. Biol. Chem. 267:15176-15183). Here we show that this stimulation leads to maximal cell surface expression levels within 4 h after stimulation while the same endothelioma cells are also able to upregulate P-selectin at the cell surface within minutes after stimulation with PMA. Both effects are additive. The fifth TNF-induced cell adhesion mechanism is defined by mediating the binding to the ...
Nawal A. Rajab* and Zainab Ahmed Sadeq. ABSTRACT. Drug delivery through buccal mucosa is a novel method for local and systemic treatment because buccal mucosa is permeable with rich blood supply and allow long- time retention of dosage from. The objective of this study is to prepare captopril as mucoadhesive buccal patch by solvent casting method and studying the effect of changing plasticizer type and increasing the drug amount on the physical and mechanical behavior of film and in vitro drug release study .The patch was prepared using hydroxylpropyl methyl cellulose K4 (HPMC) as patch forming polymer with secondary polymer (carbopol 934) and propylene glycol as plasticizer (30% of total polymer weight). The patches were prepared by solvent casting method and evaluated for weight variation, surface pH, mechanical properties, content uniformity, ex-vivo mucoadhesive strength and in-vitro drug release study. Formula F5containing HPMC as primary polymer with carbopol 934 as secondary polymer was ...
Sterile, non-adhesive, non-occlusive wound contact dressing. Indicated for low to moderate exuding partial- and full-thickness wounds. Ideal to use on wounds with fragile surrounding skin. Apply directly to the wound and cover with a secondary dressing.
In figure 1, a nanoparticle is shown dispersed in a liquid, which also contains surface active molecules (adhesion molecules). The particle diffuses towards the cell surface, makes contact and then wanders around the local area. It may find a point of entry or it may dislodge and continue its Brownian exploration of the fluid [4]. This process is similar to that involved in a virus infecting lung cells. A paper in this volume shows that the presence of nanoparticles can influence the progress of influenza virus infection [5].. To start this volume, we describe van der Waals force which is the source of adhesion in geckos that run up walls and under ceilings without any adhesive [6]. Next, by considering adhesion of ants feet under water [7], it becomes clear that the presence of a liquid has a large influence on van der Waals adhesion, decreasing the adhesion force by an order of magnitude. However, there is also the confusing effect that liquids may hugely increase the contact area, which may ...
An intraluminal grafting system having a balloon catheter assembly, a capsule catheter assembly and capsule jacket assembly is used for deploying in the vessel of an animal body a bifurcated graft having a plurality of attachment systems. The deployment catheters contain an ipsilateral capsule assembly, a contralateral capsule assembly and a distal capsule assembly, wherein the attachment systems of the bifurcated graft are disposed within the three capsule assemblies. A removable sheath of the capsule jacket assembly covers the bifurcated graft and capsule assemblies to provide a smooth transition along the length of the deployment catheters. The bifurcated graft is comprised of a main tubular member and two tubular legs, having attachment systems with wall engaging members secured to the superior end of the main tubular member and the inferior ends of the tubular legs. An inflatable membrane configured on the balloon catheter is used to firmly implant the attachment systems within the vessel. The
A graft for repairing defects in arteries is formed from a flexible graft and at least one attachment system. A device and method is disclosed for implanting a graft within the vasculature of a patient, in which the graft is inserted into the patient at a different stage than the attachment systems, and which allows for direct percutaneous insertion of the graft and attachment systems. The method permits control over the position of the graft in the vasculature during the course of deployment of the graft and attachment systems by providing for traction forces to be applied to opposing ends of the graft.
The LOCATOR Overdenture Attachment System has a patented pivoting action and self-aligning design that enables dental patients to seat their overdenture.
Surface energy is a measure of disruption of chemical bonds that occurs when a surface is created. Most of the hydrophobic surfaces are known to show low surface energy values. It is also well known that hydrophobicity has a role in cell attachment to the surface and biofilm formation. As the biofilm progresses the adhesion is higher and chemical bonding is more hence lower the surface energy. Few studies were carried out on adhesion of biological systems such as proteins, microbes, algae and invertebrates. They all show minimal long-term adhesion associated with surfaces having low energy surfaces. However, all surfaces rapidly become modified on immersion in natural waters through the adsorption of conditioning films, which may influence subsequent adhesive events associated with the permanent attachment of organisms. The results show that surface energy can elicit different responses in different organisms. For most organisms, minimal adhesion is associated with low surface energy. According ...
Nail care is a vital part of your pets total health care. Because nails continuously grow and are not necessarily worn down as they could if they have been going for walks, in that case it is up to you to help in keeping them at a more comfortable length. Whenever nails are too long, this affects the manner a dog walks which may lead to inflammation of the joints later on in life. Additionally longer nails could possibly get snagged as well as torn, or on occasion curl back into the toe pad and may also cause an infection. Trimming nails is not that upsetting if you have the correct gear and have taught your dog to let you hold the paw.. The nail has a "quick" which houses the veins and nerves of the nail.The quick is easier to see in white nails. By trimming small amounts at any given time and trimming with the plane of the bottom part of the toe pad (horizontally rather than vertically) you can keep from cutting the nail to short as to make it bleed.. Here are a few additional guidelines to ...
Buy Biofilms, Bioadhesion, Corrosion, and Biofouling (9781578080137): NHBS - Edited By: Milton Fingerman, Rachakonda Nagabhushanam and Mary-Frances Thompson, Science Publishers
The objective of the present study was to develop mucoadhesive buccal films of losartan potassium using sodium alginate, chitosan, and their conjugated derivatives at different concentrations by solvent casting technique. Glycerin was used as plasticizer, at different weight ratios. The conjugation of polymers (sodium alginate-cysteine and chitosan-thioglycolic acid) was confirmed by FTIR study. The resulted conjugated sodium alginate and chitosan displayed 475.64±24.31 and 305±31.21 μmol thiol groups per g conjugate, respectively. The developed films were evaluated by different parameters such as weight uniformity, thickness, surface pH, swelling index, in vitro residence time, mucoadhesive strength, in vitro and ex vivo drug permeation. The results indicated that the formulations S5, C4, Cs and Cc showed better characteristic properties and drug permeation. Good results were obtained both in vitro and ex vivo conditions for optimized film. A higher glycerin percent in films increased the ...
Textile materials with self-cleaning and antimicrobial properties are desirable, given the limited resources required for laundry and the concern for astronauts health, microbial deterioration of materials (e.g., fabrics/surfaces discoloration, unpleasant odors), and interplanetary contamination. It is hypothesized that the use of textiles and garments can be extended to periods of weeks or months by the use of antimicrobial textiles, which prevent or inhibit microbial growth on fabrics.. Advances in textile technology have guided the development of antimicrobial agents consisting of metal (e.g., silver), metal oxides (e.g., copper oxide), and quaternary ammonium compounds. Some of these antimicrobial agents have been utilized in combating bacterial pathogens in a host of commercial products including wound dressings, medical devices, bed linens, paints, etc. Although silver ions is one of the most widely used metal-based, antimicrobial agents in the market, copper oxide impregnated products ...
Inspired by the agile geckos uncanny ability to run up walls and across ceilings, researchers at Rensselaer Polytechnic Institute and the University of Akron have been successful in creating a synthetic "gecko tape" with four times the sticking power of the real thing.. According to Pulickel Ajayan, the Henry Burlage Professor of Materials Science and Engineering at Rensselaer, and Lijie Ci (a postdoctoral research associate in Ajayans lab):. "Several people have tried to use carbon nanotube films and other fibrous structures as high-adhesive surfaces and to mimic gecko feet, but with limited success when it comes to realistic demonstrations of the stickiness and reversibility that one sees in gecko feet.. We have shown that the patchy structures from micropatterned nanotubes are essential for this unique engineering feat to work. The nanotubes also need to be the right kind, with the right dimensions and compliance.. Geckos inspired us to develop a synthetic gecko tape unlike any youll find ...
Self-cleaning printer having ultrasonics and method of assembling same for cleaning a print head surface and ink ejection orifices. The printer comprises a print head defining a plurality of ink channels therein, each ink channel terminating in an ink ejection orifice. The print head also has a surface thereon surrounding all the orifices. Particulate matter may reside on the surface and also may completely or partially obstruct the orifice. Therefore, a cleaning assembly is disposed relative to the surface and/or orifice for directing a flow of fluid along the surface and/or across the orifice to clean the particulate matter from the surface and/or orifice. The cleaning assembly includes an ultrasonic transducer in communication with the fluid for generating ultrasonic vibrations causing pressure waves within the fluid. Presence of the pressure waves induces a hydrodynamic force in the fluid. This force acts against the particulate matter to clean the particulate matter from the surface and/or orifice.
WHIRLPOOL 5.0 Cu. Ft. Self-Cleaning Freestanding Gas Range: Counter depth range; Sabbath mode; 4 burners, including SpeedHeat and AccuSimmer burners; 5,000-15,000 BTUs of heat; AccuBake temperature management; delay-bake option; storage drawer
In this study, efficient, high-precision grinding of cemented carbide alloys using a specific grinding wheel was performed, and the ground surface characteristics were investigated in detail. The results showed that final finishing using a chromium-bonded wheel produced an extremely smooth surface with an average roughness Ra of 4 nm. The grinding process produced a chromium- and copper-rich surface layer, as well as a large amount of diffusion of oxygen. Adhesive strength tests using a microscratching method were also carried out on ground substrates coated with diamond-like carbon (DLC) films. The surface ground by the chromium-bonded wheel exhibited superior adhesive strength due to its strong chemical affinity with the DLC film.. ...
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We demonstrated that the integuments of A. alneti are completely repellent to the exudates of that insect owing to their brochosomal coats. The observed difference in contaminability between the intact and bare wings-three versus 152 spots-is striking. Moreover, the three spots recorded on the intact wings only marginally extended onto the wing and probably resulted from lateral spreading of exudate from the adjacent stub, which can be considered as an experimental artefact.. The observed effect is explained by superhydrophobic properties of brochosomal coats, recently demonstrated for A. alneti and two other leafhopper species through static contact angle measurements [3]. These properties appear to result from the complex surface geometry of brochosomal layers, forming hierarchical roughness at the micro- and nanoscales (figure 3c,d), as is typical of natural and artificial superhydrophobic and self-cleaning surfaces (reviewed in [1,2]). Our extremely low estimates of the surface free energy ...
Like the honey that slithers down this low-fat version of a classic dessert, the flavor and history of this flan cling to taste buds and refuse to let go. Like the honey that slithers down this low-fat version of a classic dessert, the flavor and history of this flan cling to taste buds and refuse to let go. Like the honey that slithers down this low-fat version of a classic dessert, the flavor and history of this flan cling to taste buds and refuse to let go.
2.8)where U(x) is the van der Waals potential energy; γ the interlayer cohesive energy density for a single MWNT layer; C the circumference of the active nanotube bearing cylinder; and x the length of the overlap between the core section and the outer layer. It is interesting to note that the interlayer force is independent of the overlap length. For the nanotube in figure 10, the van der Waals force was estimated to be 9 nN. Based on the observation that complete retraction occurred between two frames of the video recording (Δt=33 ms), Cumings & Zettl estimated limits on the static friction force fs,23 fN per atom and the dynamic friction force fd,15 fN per atom.. As these limits were based on estimates, it was however unclear at this point what the magnitude of interlayer force and friction would be, if the interlayer friction would scale with the length of the moving segment, and how it would evolve during prolonged actuation and damage to the nanotube. The magnitude of the surface energy ...
Citation: Gamble, G. 2003. Evaluation of cotton stickiness via the thermochemical production of volatile compounds. Journal of Cotton Science 7(2):45-50. Interpretive Summary: STICKY COTTON IS A FREQUENTLY ENCOUNTERED PHENOMENON AND PRESENTS A MAJOR CONCERN FOR THE TEXTILE INDUSTRY. STICKINESS IS CAUSED PRIMARILY BY THE PRESENCE OF INSECT HONEYDEW CONTAMINATED ON THE COTTON LINT, AND CAUSES PROBLEMS AT VARIOUS STAGES OF PROCESSING INCLUDING GINNING, CARDING, AND YARN SPINNING. DETECTION OF STICKY COTTON IN A RAPID, RELIABLE, AND COST EFFECTIVE MANNER BEFORE IT REACHES THESE PROCESSING STAGES IS THEREFORE A COMMON GOAL OF THE INDUSTRY. THE RESEARCH PRESENTED HERE DEMONSTRATES THAT BY HEATING CONTAMINATED COTTON TO TEMPERATURES REGULARLY ENCOUNTERED IN THE GIN, VOLATILE COMPOUNDS RELEASED AS A RESULT OF HONEYDEW SUGAR DEGRADATION CAN BE MEASURED AND USED TO SCREEN COTTON FOR POTENTIAL STICKINESS. THIS WORK LAYS THE FOUNDATION FOR THE DEVELOPMENT OF A RAPID, RELIABLE, AND COST EFFECTIVE METHOD FOR ...
Calcium deficiencies are common heath issue in Tokay geckos which may lead to serious health issues like Metabolic Bone Disease or MBD. Like any other reptiles, Tokay geckos need calcium for them to grow and produce healthy eggs. Calcium is an important mineral to a reptiles health but giving them with a bowl of calcium daily doesnt guarantee that they absorb or get the right amount of calcium. It is important to note however, that calcium absorption is a process that involves other processes to be able to efficiently deliver calcium in the system. Other than giving your Tokay geckos a daily dose of calcium it is also important that your Tokay geckos have enough Vitamin D3 in their system. Vitamin D3 is naturally produced in a reptiles body when exposed to UVB (ultraviolet light B) which can be done using UVB lighting or exposing your Tokay geckos to natural sunlight. UVB rays trigger the kidneys of reptiles to create vitamin D3 which is delivered into their bloodstream and enable the cells ...
Antiohos, Dennis, Mark S. Romano, Joselito M. Razal, Stephen Beirne, Phil Aitchison, Andrew I. Minett, Gordon G. Wallace, Jun Chen "Performance enhancement of single-walled nanotube-microwave exfoliated graphene oxide composite electrodes using a stacked electrode configuration" J. Mater. Chem. A (2014) 2: 14835-14843. doi:10.1039/c4ta02190h ...
In this work, we present an approach to achieve improved adhesive bonding with a poly(tetrafluoroethylene) (PTFE) substrate. Surfaces were modified by abrasion, atmospheric air plasma torch (APPT) treatment, and by immersion in basic (NaOH) and strongly acidic In this work, we present an approach to achieve improved adhesive bonding with a poly(tetrafluoroethylene) (PTFE) substrate. Surfaces were modified by abrasion, atmospheric air plasma torch (APPT) treatment, and by immersion in basic (NaOH) and strongly acidic/oxidizing (HNO3/KMnO4) solutions. The wetting properties of the polymer were studied in terms of surface energy, and adhesion tests were carried out using polyurethane, acrylic, and epoxy adhesives. The surface characterisation included surface energy calculation through contact angle measurements, infrared spectroscopy (FTIR-ATR), scanning electron microscopy (SEM), and X-ray electron diffraction (EDX). Adhesion was evaluated by pull-off tests following the UNE EN-24624 standard. ...
DISCUSSION. Buccal cells are an excellent source of DNA for diagnosis and large scale molecular epidemiological studies. Several protocols have been developed to obtain DNA from buccal cells, but cell collection by mouthwash seems to give higher yields than many other methods (1). In this study, it was noted that the rubbing of the tongue on the teeth and oral mucosa permitted a great increase in the amount of epithelial buccal cells collected. This procedure, however, increases the viscosity of the mouthwash solution, making it difficult, in some cases, to pellet the cells. This probably occurs due to high concentrations of salivary mucins in the mouthwash, which can hinder the collection of buccal cells after centrifugation. We have found that the addition of TNE reduces significantly the viscosity of the mouthwash. In fact, salivary viscosity is believed to occur due to the entanglement of long, high molecular weight oligomeric mucins (13). The interaction of mucins seems to be mediated by ...
Ammonia has the ability to form hydrogen bonds. When the hydrogen bonds between water molecules are broken, they can be replaced by equivalent bonds between water and ammonia molecules. Some of the ammonia also reacts with the water to produce ammonium ions and hydroxide ions. The reversible arrows show that the reaction doesnt go to completion. At any one time only about 1% of the ammonia has actually reacted to form ammonium ions. The solubility of ammonia is mainly due to the hydrogen bonding and not the reaction. Other common substances which are freely soluble in water because they can hydrogen bond with water molecules include ethanol (alcohol) and sucrose (sugar). Solubility in organic solvents Molecular substances are often soluble in organic solvents - which are themselves molecular. Both the solute (the substance which is dissolving) and the solvent are likely to have molecules attracted to each other by van der Waals forces. Although these attractions will be disrupted when. ...
The authors demonstrate a high performance electrically controlled birefringence (ECB) mode with solution-derived La{sub 2}O{sub 3} films at various molar concentrations. Uniform and homogeneous liquid crystal (LC) alignment was spontaneously achieved on the La{sub 2}O{sub 3} films for lanthanum concentrations at ratios greater than and equal to 0.2. A preferred orientation of LC molecules appeared along the filling direction, and the LC alignment was maintained via van der Waals force by nanocrystals of the La{sub 2}O{sub 3} films. The LC alignment mechanism was confirmed by x-ray photoelectron spectroscopy and high-resolution transmission electron microscopy analysis. Superior electro-optical characteristics of the ECB cells constructed with solution-derived La{sub 2}O{sub 3} films were observed, which suggests that the proposed solution-derived La{sub 2}O{sub 3} films have strong potential for use in the production of advanced LC displays. ...
The increase of erythrocyte aggregation by high fibrinogen levels may be an indicator of cardiovascular risk. γ′ fibrinogen variant has been considered as a possible player in enhancing aggregation. Here, we assessed, at the single-cell level, the influence of fibrinogen on erythrocyte aggregation in essenti
A pressure sensitive adhesive sheet comprising a substrate and an adhesive composition which is coated on the surface of the substrate. The main components of the adhesive composition are (a) a copolymer comprising monomeric units of an acrylic ester, (b) monomeric units of a polar acrylic compound, (c) monomeric units of a high glass transition temperature (Tg) macromonomer having a Tg of 20.degree. C. or above, (d) monomeric units of a low Tg macromonomer having a Tg of below 20.degree. C. and (e) monomeric units of an oligomer having telechelic thiol functional groups. The pressure sensitive adhesive sheet has excellent adhesive strength, resistance against formation of blisters and removability upon heating.
Left: A female Neoscona oaxacensis orb-weaving spider. Top: Cheiracanthium spiders are known as yellow sac spiders. They are usually pale colored and are 1/5 to
I made this fudge for Thanksgiving (with milk chocolate chips, peanut butter chips, and walnuts) and it came out great. I decided to make some to ship in tins to friends/family at Christmas. I have never shipped fudge before, so if anyone has any tips on how to ship it successfully please let me know. I am still making the gift tins, but so far I poured the fudge for two "test tins" right into the decorative tin, which was lined with 2 layers of cling wrap. After it was solid, I took it out of the cling wrap, wrapped the block in a sheet of wax paper (to make it look neater), and then put it back in the tin. I am planning to ship it this way, and hope it doesnt melt! It seems to have worked well so far, and I hope to mail it within the next day or so. In the future I think I will stick with making fudge only for people who leave near me, but I already committed myself this year, so I hope it works out. Again, any comments or advice would be welcome...thank you! ...
2014) Correction to "Effect of Nonelectrostatic Ion Interactions on Surface Forces Involving Ion Adsorption Equilibria". The Journal of Physical Chemistry C, 118 (36). p. 21299. ...
The geckos amazing ability to "stick" to substrates has inspired numerous adhesive technologies that will bond with substrates and then release their grip in response to temperature changes, light exposure, or magnetic fields. But this biomimicry has only been used in dry conditions so far. Now scientists say that a double-sided adhesive that works in wet conditions is feasible.. Researchers examined hydrogels that can contract and expand depending on pH and other variables. The development was reported in ACS Journal of Physical Chemistry C. They were able to integrate nanostructured hydrogel fibers on an inorganic membrane. It responded to alterations in pH, providing high friction and strong adhesion at an acidic pH and switching to low friction and adhesion at high pH. By incorporating the hydrogel on both sides of the membrane, they were able to obtain a tape that could behave in different ways on either side of the membrane. The research team has posited possible uses for its discovery, ...
Mesocletodes Sars, 1909a encompasses 37 species to date. Initial evidence on intraspecific variability and sexual dimorphism has been verified for 77 specimens of Mesocletodes elmari sp. n. from various deep-sea regions, and ontogenetic development has been traced for the first time. Apomorphies are a strong spinule- like pinna on the mx seta that is fused to the basis, P2-P4 exp3 proximal outer seta lost, P1-P4 enp2 extremely elongated, furcal rami elongated, female body of prickly appearance, female P2-P4 enp2 proximal inner seta lost. Intraspecific variability involves spinulation, ornamentation and size of the body and setation and spinulation of pereiopods. Sexually dimorphic modifications of adult females include prickly appearance of the body, P1 enp exceeds exp in length, P1 coxa externally broadened, seta of basis arising from prominent protrusion, hyaline frills of body somites ornate. Sexual dimorphism in adult males is expressed in smaller body size, haplocer A1, 2 inner setae on ...
cell dissociation solution and cell dissociation solution manufaturers - 106 cell dissociation solution manufacturers & cell dissociation solution provide quality cell dissociation solution from China.
This application note analyzes the role of different adhesion molecules and chemokines involved in various stages of inflammation under physiological flow conditions. Using Cellixs biochips and Mirus pumping system, THP-1, monocyte and PBMC adhesion to VCAM-1; THP-1, monocyte and PBMC rolling on E-selectin; and respective adhesion blockades is investigated. THP-1 adhesion to HUVECs, correlating adhesion assay results with adhesion molecule expression levels on HUVECs from flow cytometry data, i
Expression of cyclooxygenases (COX) and lipoxygenases (LOX) has been linked to many pathophysiological phenotypes, including cell adhesion. However, many current approaches to measure cellular changes are performed only in a fixed-time point. Since cells dynamically move in conjunction with the cell matrix, there is a pressing need for dynamic or time-dependent methods for the investigation of cell properties. In the presented study, we used stable human colorectal cancer cell lines ectopically expressing COX-1, COX-2, and 15LOX-1, to investigate whether expression of COX-1, COX-2, or 15LOX-1 would affect cell adhesion using our opto-electric methodology. In a fixed-time point experiment, only COX-1- and COX-2-expressing cells enhanced phosphorylation of focal adhesion kinase, but all the transfected cells showed invasion activity. However, in a real-time experiment using opto-electric approaches, transmitted cellular morphology was much different with tight adhesion being shown in COX-2 expressing
Background: Mast cells infiltrate the bronchial smooth muscle (BSM) in asthmatic patients, but the mechanism of mast cell adhesion is still unknown. The adhesion molecules CD44 (i.e. hyaluronate receptor) and CD51 (i.e. vitronectin receptor) are widely expressed and bind to many extracellular matrix (ECM) proteins. The aims of the study are (i) to identify the role of ECM in mast cell adhesion to BSM and (ii) to examine the role of CD51 and CD44 in this adhesion.. Methods: Human lung mast cells, human mast cell line (HMC-1), and BSM cells from control donors or asthmatic patients were cultured in the presence/absence of various cytokines. Mast cell-BSM interaction was assessed using 3H-thymidine-pulsed mast cells, confocal immunofluorescence, or electron microscopy. Adhesion molecules expression and collagen production on both cell types were evaluated by quantitative RT-PCR, western blot, and flow cytometry.. Results: Mast cell adhesion to BSM cells mostly involved type I collagen of the ECM. ...
The extravasation of leukocytes from the blood into tissues occurs as a multistep process: an initial transient interaction ("rolling"), generally thought to be mediated by the selectin family of adhesion molecules, followed by firm adhesion, usually mediated by integrins. Using a parallel plate flow chamber designed to approximate physiologic flow in postcapillary venules, we have characterized a rolling interaction between lymphoid cells and adherent primary and cultured endothelial cells that is not selectin mediated. Studies using blocking monoclonal antibodies indicate that this novel interaction is mediated by CD44. Abrogation of the rolling interaction could be specifically achieved using both soluble hyaluronate (HA) and treatment of the adherent cells with HA-reactive substances, indicating that HA is the ligand supporting this rolling interaction. Some B and T cell lines, as well as normal lymphocytes, either constitutively exhibit rolling or can be induced to do so by phorbol ester or ...
Renal sympathetic denervation (RSD) is a treatment option for patients with resistant arterial hypertension, but in some patients it is not successful. Predictive parameters on the success of RSD remain unknown. The angiogenic factors soluble fms-like tyrosine kinase-1 (sFLT-1), intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) are known to be associated with endothelial dysfunction, vascular remodeling, and hypertension. We evaluated whether sFLT-1, ICAM-1, and VCAM-1 are predictive markers for blood pressure reduction after RSD. Consecutive patients (n=55) undergoing renal denervation were included. Venous serum samples for measurement of sFlt-1, ICAM-1, and VCAM-1 were collected before and 6 months after RSD. A therapeutic response was defined as an office systolic blood pressure reduction of ,10 mm Hg 6 months after RSD. A significant mean office systolic blood pressure reduction of 31.2 mm Hg was observed in 46 patients 6 months after RSD. Nine ...
We have previously reported a newly discovered congenital disorder of neutrophil adhesion, leukocyte adhesion deficiency syndrome type 2 (LAD II). The clinical manifestations of this syndrome are similar to those seen in the classic leukocyte adhesion deficiency syndrome, now designated type 1 (LAD I), but the two syndromes differ in the molecular basis of their adhesion defects. LAD I is caused by a deficiency in the CD18 integrin adhesion molecules while LAD II patients are deficient in expression of sialyl-Lewis X (SLeX), a carbohydrate ligand for selectins. In this report we demonstrate that neutrophils from a LAD II patient bind minimally or not at all to recombinant E-selectin, purified platelet P-selectin, or P-selectin expressed on histamine-activated human umbilical vein endothelial cells, but have normal levels of L-selectin and CD11b/CD18 integrin, and adhere to and migrate across endothelium when CD11b/CD18 is activated. We compare LAD I and LAD II patient neutrophil function in ...
This chapter provides a review of the various traditional approaches of antiadhesion therapy and immunity, including the usef of adhesin-based vaccines, receptor and adhesin analogs, sub-lethal concentrations of antibiotics, dietary constituents, and innate host-derived antiadhesion factors. The adhesin analog strategy is based on the assumption that the isolated adhesin molecule or its synthetic or recombinant fragment binds to the receptor and thereby competitively blocks adhesion of the bacteria. It has so far been impractical to use adhesin analogs in antiadhesion therapy because they are almost always macromolecules that must be employed in relatively high molar concentrations and they are available only in limited supply. In addition, careful consideration must be given to their toxicity and immunogenicity. Nevertheless, modern proteomics and recombinant biotechnology have permitted the development of unique types of relatively small peptides for antiadhesion therapy. The chapter talks about the
The integrin LFA-1 and its ligand ICAM-1 mediate B cell adhesion, but their role in membrane-bound antigen recognition is still unknown. Here, using planar lipid bilayers and cells expressing ICAM-1 fused to green fluorescence protein, we found that the engagement of B cell receptor (BCR) promotes B cell adhesion by an LFA-1-mediated mechanism. LFA-1 is recruited to form a mature B cell synapse segregating into a ring around the BCR. This distribution is maintained over a wide range of BCR/antigen affinities (10(6) M(-1) to 10(11) M(-1)). Furthermore, the LFA-1 binding to ICAM-1 reduces the level of antigen required to form the synapse and trigger a B cell. Thus, LFA-1/ICAM-1 interaction lowers the threshold for B cell activation by promoting B cell adhesion and synapse formation.
The aim of the first part of the thesis was to develop and validate an in vitro adherence assay involving porcine mononuclear cells (MCs) and porcine endothelium, present within gut and lymph node. Factors involved in MC / endothelium interactions were determined. In summary we found that cell adhesion in our assay system was temperature, Ca2+ and Mn2+ sensitive, required metabolic activity, was inhibited by the phosphorylated monosaccharide galactose 6-phosphate, and unaffected by the presence of mucus. These findings reflected certain aspects of in vivo cell adhesion, present within the in vitro assay used. The adhesion characteristics of porcine Peyer s patch (PP), peripheral blood (PB), and lymph node (LN) MCs to porcine gut and lymph node endothelium was examined and used as an guiding model for the future study of human MCs adherence. It was found that PP MCs adhered significantly better to gut endothelium than to LN endothelium and similarly LN MCs adhered significantly better to LN ...
cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00059 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00084 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00084 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA contains a PF00008 domain.. cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA is proteolytically cut by matrix metallopeptidase-3 (M10.005) cleavage... cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA is proteolytically cut by matrix metallopeptidase-1 (M10.001) cleavage... cDNA, FLJ93066, Homo sapiens selectin L (lymphocyte adhesion molecule 1) (SELL),mRNA is proteolytically cut by ADAM17 peptidase (M12.217) cleavage. KLDK-SFSM.. ...
cell adhesion assay - posted in Cell Biology: Hi, Im currently oerforming cell adhesion assays on my cell lines expressing my gene of interest vs cell line transfected with vector only. Im using a colorimetric method. Howver, I do not understand the rationale behind this assay. If a cell line is tumor suppressive, do we expect it to have more cells adhering, i.e higher abosrbance reading comapred to the control or vice versa? I thought if a cell line is tumor suppresisve, mo...
Approach and Results-We used an ex vivo protocol for immunofluorescence in human vessels, allowing detailed en face microscopy of endothelial monolayers. We compared arteries and veins of the umbilical cord and mesenteric, epigastric, and breast tissues and find that the presence of central F-actin fibers distinguishes the endothelial phenotype of adult arteries from veins. F-actin in endothelium of adult veins as well as in umbilical vasculature predominantly localizes cortically at the cell boundaries. By contrast, prominent endothelial F-actin fibers in adult arteries anchor mostly to focal adhesions containing integrin-binding proteins paxillin and focal adhesion kinase and follow the orientation of the extracellular matrix protein fibronectin. Other arterial F-actin fibers end in vascular endothelial-cadherin-based endothelial focal adherens junctions. In vitro adhesion experiments on compliant substrates demonstrate that formation of focal adhesions is strongly induced by extracellular ...
Cell-matrix and cell-cell adhesions are often characterized as functionally distinct adhesion systems within the cell that mediate different proliferative outcomes. In contrast to the widely accepted pro-proliferative effect of cell-matrix adhesion, the proliferative effect of cadherin-dependent cell-cell adhesion remains unresolved. While the majority of studies demonstrate that cadherins mediate contact inhibition of proliferation, there have also been compelling reports of cadherins stimulating cell cycling. Here, we show that matrix stiffness is the mechanistic basis for crosstalk between N-cadherin at cell-cell junctions and focal adhesion kinase (FAK) at cell-matrix adhesions, and that this interplay between adhesive systems modulates the proliferative role of N-cadherin. We demonstrate that N-cadherin is induced in smooth muscle cells (SMCs) following vascular injury, an in vivo model of tissue stiffening and proliferation. Complementary experiments on deformable polyacrylamide hydrogels
Cell adhesion to extracellular matrix (ECM) is critical to various cellular processes like cell spreading, migration, growth and apoptosis. At the tissue level, cell adhesion is important in the pathological and physiological processes that regulate the tissue morphogenesis. Cell adhesion to the ECM is primarily mediated by the integrin family of receptors. The receptors that are recruited to the surface are reinforced by structural and signaling proteins at the adhesive sites forming focal adhesions that connect the cytoskeleton to further stabilize the adhesions. The functional roles of these focal adhesions extend beyond stabilizing adhesions and transduce mechanical signals at the cell-ECM interface in various signaling events. The objective of this research is to analyze the role of the spatial distribution of the focal adhesions in stabilizing the cell adhesion to the ECM in relation to cells internal force balance. The central hypothesis was that peripheral focal adhesions stabilize cell
Lu, Yiling and Li, Wei-Qi and Oraifige, I. and Wang, Wen (2014) Converging parallel plate flow chambers for studies on the effect of the spatial gradient of wall shear stress on endothelial cells. Journal of Biosciences and Medicines, 2. pp. 50-56. ISSN 2327-5081 ...
Focal adhesion assembly and disassembly are essential for cell migration and cancer invasion, but the detailed molecular mechanisms regulating these processes remain to be elucidated. Phosphatidylinositol phosphate kinase type Iγ (PIPKIγ) binds talin and is required for focal adhesion formation in EGF-stimulated cells, but its role in regulating focal adhesion dynamics and cancer invasion is poorly understood. We show here that overexpression of PIPKIγ promoted focal adhesion formation, whereas cells expressing either PIPKIγK188,200R or PIPKIγD316K, two kinase-dead mutants, had much fewer focal adhesions than those expressing WT PIPKIγ in CHO-K1 cells and HCT116 colon cancer cells. Furthermore, overexpression of PIPKIγ, but not PIPKIγK188,200R, resulted in an increase in both focal adhesion assembly and disassembly rates. Depletion of PIPKIγ by using shRNA strongly inhibited formation of focal adhesions in HCT116 cells. Overexpression of PIPKIγK188,200R or depletion of PIPKIγ reduced the
In this paper we show that collagenase-3 cleavage of type I collagen has a marked effect on alpha2beta1 integrin-mediated interactions with the collagen fragments generated. Isolated alpha2beta1 integrin and alpha2 integrin A-domain were found to bind to both native collagen and native 3/4 fragment and, to a lesser degree, native 1/4 fragment. Whole integrin and integrin A-domain binding were lost after heat denaturation of the collagen fragments. At physiological temperature, cell adhesion to triple-helical 3/4 fragment via alpha2beta1 integrin was still possible; however, no alpha2beta1 integrin-mediated adhesion to the 1/4 fragment was observed. Unwinding of the collagen fragment triple helices by heating to physiological temperatures prior to adsorption to plastic tissue culture plates resulted in total abrogation of HT1080 cell attachment to either fragment. These results provide significant evidence in support of a role for matrix-metalloproteinase cleavage of the extracellular matrix in ...
Interference reflection microscopy (IRM) is an optical technique used to study cell adhesion or cell mobility on a glass coverslip
The effect of androgens on different aspects of atherogenesis has received little attention despite the marked male predisposition to occlusive vascular disease.1 2 In the present study, we have demonstrated that androgen exposure leads to a dose-related and receptor-mediated increase in human monocyte adhesion to endothelial cells, a key early event in atherosclerosis. This effect is mediated at least in part by an androgen receptor-dependent increase in endothelial cell expression of the important adhesion molecule VCAM-1.. A proatherogenic effect of androgens is supported by recent work in experimental animals. For example, Adams et al8 documented an approximate doubling of coronary artery plaque size in female postmenopausal cynomolgus monkeys treated with testosterone and a cholesterol-enriched diet, and Hutchison et al16 documented arterial endothelial dysfunction in hypercholesterolemic rabbits that were administered androgens. Similar data are not available in humans.. The incidence of ...
Looking for online definition of leukocyte adherence assay test in the Medical Dictionary? leukocyte adherence assay test explanation free. What is leukocyte adherence assay test? Meaning of leukocyte adherence assay test medical term. What does leukocyte adherence assay test mean?
We review evidence concerning the basis for tissue segregation during embryonic development. This compartmentalization is shown to be an immiscibility phenomenon caused by changes in the strengths of adhesions between mobile cells which accompany their differentiation and generate interfacial tensions at cell population boundaries. The mobile cells exchange neighbors in response to these adhesion-generated forces which impel the system toward the configuration of maximal binding. Cadherins dominate these intercellular adhesions, but integrin-fibronectin-based adhesions also contribute to them as well as to cell-matrix adhesions. At the interface between two segregating cell populations are three kinds of cell-cell interfaces: a-a, b-b and a-b. Tissue immiscibility (segregation) results when the cross-adhesion is weaker than the mean value of the two kinds of self-adhesions, does not require (although it permits) qualitative changes in cell adhesion molecules and is easily generated even by
Synaptic cell adhesion molecules (SynCAMs) are crucial for synapse formation and plasticity. However, we have previously demonstrated that SynCAMs are also required during earlier stages of neural circuit formation because SynCAM1 and SynCAM2 (also known as CADM1 and CADM2, respectively) are important for the guidance of post-crossing commissural axons. In contrast to the exclusively homophilic cis-interactions reported by previous studies, our previous in vivo results suggested the existence of heterophilic cis-interactions between SynCAM1 and SynCAM2. Indeed, as we show here, the presence of homophilic and heterophilic cis-interactions modulates the interaction of SynCAMs with trans-binding partners, as observed previously for other immunoglobulin superfamily cell adhesion molecules. These in vitro findings are in agreement with results from in vivo studies, which demonstrate a role for SynCAMs in the formation of sensory neural circuits in the chicken embryo. In the absence of SynCAMs, ...
Metastasizing tumor cells show increased expression of the intermediate filament (IF) protein vimentin, which has been used to diagnose invasive tumors for decades. Recent observations indicate that vimentin is not only a passive marker for carcinoma, but may also induce tumor cell invasion. To clarify how vimentin IFs control cell adhesions and migration, we analyzed the nanoscale (30-50 nm) spatial organization of vimentin IFs and cell-matrix adhesions in metastatic fibroblast cells, using three-color stimulated emission depletion (STED) microscopy. We also studied whether wild-type and phospho-deficient or -mimicking mutants of vimentin changed the size and lifetime of focal adhesions (FAs), cell shape, and cell migration, using live-cell total internal reflection imaging and confocal microscopy. We observed that vimentin exists in fragments of different lengths. Short fragments were mostly the size of a unit-length filament and were mainly localized close to small cell-matrix adhesions. Long ...
An altered expression of the activated leukocyte cell adhesion molecule (ALCAM) is associated with cancer progression in various cancer types. In some cancers ALCAM has a prognostic value or is predictive for the benefit of therapeutic interventions. To date there are no data on the role of ALCAM in cervical cancer available. In this study, ALCAM expression was analysed by immunohistochemistry (IHC) in tissue samples of 233 patients with cervical cancer, among them 178 with complete follow-up information. In addition, soluble (s-)ALCAM was measured in sera of a subset of the included patients (n = 55) by enzyme-linked immunosorbent assay (ELISA). ALCAM overexpression was detected (immunoreactive score (IRS) 2-12) in 58.4% of the cervical cancer samples. The normal ectocervical or endocervical epithelium showed no ALCAM reactivity. In untreated patients, ALCAM overexpression in tumor tissue tended to be associated with shorter cancer-specific survival (CSS) and disease-free survival (DFS). Patients,
Inflammation is related to many diseases, such as atherosclerosis, rheumatoid arthritis and metabolic diseases. Vascular adhesion protein-1 (VAP-1) is an endothelial adhesion molecule involved in leukocyte trafficking cascades from blood circulation to the sites of inflammation. In normal condition, VAP-1 is stored in intracellular granules. During inflammation it is rapidly translocated from the intracellular storage granules to the endothelial cell surface. Siglec-9 is a leukocyte ligand of VAP-1 and Siglec-9 motif containing peptide can be used as a positron emission tomography (PET) tracer for in vivo imaging of inflammation-related diseases ...
Results Thrombin (0.08 to 0.2 U/ml) increased platelet adhesion in a dose-dependent manner from 2.7 ± 0.3% to 6.4 ± 0.6% (mean value ± SEM). Preincubation of platelets resulted in a dose-dependent down-regulation of 3H-iloprost binding up to 58.8 ± 6.7% of control platelets with 100 nmol/liter of iloprost. Co-incubation of prostacyclin receptor-desensitized platelets with endothelial cells resulted in a marked augmentation of thrombin-induced adhesion up to 28.6 ± 4.5%. Approximately the same increase in platelet adhesion was seen after complete abrogation of endothelial cell prostacyclin synthesis by pretreatment with aspirin. Comparison of iloprost-induced receptor desensitization and increased platelet-endothelial cell adhesion indicated a positive correlation. ...
The CD11b/CD18 integrin plays a crucial role in cell-cell adhesion processes. Recently, we described a case of severe neonatal alloimmune neutropenia (NAIN) caused by an alloantibody against a variant of the CD11b subunit (Mart alloantigen). Allele-specific transfected cells allowed us to demonstrate that an H61R point mutation is directly responsible for the formation of Mart epitopes. No difference in the adhesion capability between H61 and R61 homozygous neutrophils was observed. Functional analysis showed that anti-Mart inhibited Mac-1-dependent adhesion of neutrophils and monocytic U937 cells to fibrinogen, intercellular adhesion molecule-1 (ICAM-1), receptor for advanced glycation end product (RAGE), and glycoprotein Ibα but not to junctional adhesion molecule-C or urokinase plasminogen activator receptor (uPAR). Accordingly, anti-Mart blocked neutrophil and U937 cell adhesion to endothelial cells and platelet-leukocyte aggregate formation in whole blood under high shear. Other sera of anti-Mart
Several studies support C-reactive protein (CRP) as a systemic cardiovascular risk factor. The recent detection of CRP in arterial intima suggests a dual activity in atherosclerosis as a circulating and tissue mediator on vascular and immune cells. In the present paper, we focused on the inflammatory effects of CRP on human monocytes, which were isolated by Ficoll-Percoll gradients and cultured in adherence to polystyrene, endothelial cell monolayer, or in suspension. Chemokine levels, adhesion molecule, and chemokine receptor expression were detected by ELISA, flow cytometry, and real-time RT-PCR. Migration assays were performed in a Boyden chamber. Stimulation with CRP induced release of CCL2, CCL3, and CCL4 in adherent monocytes through the binding to CD32a, CD32b, and CD64, whereas no effect was observed in suspension culture. This was associated with CRP-induced up-regulation of adhesion molecules membrane-activated complex 1 (Mac-1) and ICAM-1 on adherent monocytes. Blockade of Mac-1/ICAM-1
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in ...
Buy ALCAM elisa kit, Cavy Activated Leukocyte Cell Adhesion Molecule ELISA Kit-AAB59499.1 (MBS046317) product datasheet at MyBioSource, ELISA Kits
OBJECTIVE: The endothelial protein C-receptor (EPCR) is an endothelial transmembrane protein that binds protein C and activated protein C (APC) with equal affinity, thereby facilitating APC formation. APC has anticoagulant, antiapoptotic and antiinflammatory properties. Soluble EPCR, released by the endothelium, may bind activated neutrophils, thereby modulating cell adhesion. EPCR is therefore considered as a possible link between the anticoagulant properties of protein C and the inflammatory response of neutrophils. In the present study, we aimed to provide proof of concept for a direct binding of EPCR to the β2-integrin Mac-1 on monocytic cells under static and physiological flow conditions. MEASUREMENTS AND MAIN RESULTS: Under static conditions, human monocytes bind soluble EPCR in a concentration dependent manner, as demonstrated by flow cytometry. Binding can be inhibited by specific antibodies (anti-EPCR and anti-Mac-1). Specific binding was confirmed by a static adhesion assay, where a ...
Abstract. Objectives: Brief intravenous administration of chimeric antibody c7E3 Fab during coronary angioplasty has been shown in some studies to provide long term protection against coronary events. Smooth muscle cell (SMC) adhesion and migration are key initial steps in the development of restenosis. The purpose of this study was to investigate the effect of c7E3 Fab on adhesion and migration of SMC to the extracellular matrix (ECM) proteins osteopontin (Opn) and vitronectin (Vn). Methods: Adhesion of human vascular SMCs to ECM proteins was quantified using a CyQUANT assay kit. Migration of SMCs to Vn, Opn and PDGF was studied using a modified Boydens chamber migration assay. Integrin expression was determined by immunoprecipitation. Results: c7E3 Fab reduced SMC adhesion on Vn and Opn to 69.2±3.3% (P,0.001) and 52.5±4.8% (P,0.001) respectively, compared to adhesion without antibody present. This reduction was the same as that for anti-αvβ3 integrin antibody LM609 (P = 0.5). The ...
Ischemic injury is characterized by neutrophil (PMN)--endothelial cell adhesion and diapedesis associated with thromboxane (TX) generation. Neutrophil-endothelial cell interaction is regulated in part by the leukocyte adhesion receptor CD 18 glycoprotein complex and the endothelial intercellular adhesion molecule-1 (ICAM-1). This study tests the role of TX in ischemia-induced diapedesis and evaluates whether the diapedesis is regulated by neutrophil or endothelial adhesion receptors. Plasma derived from rabbit hind limbs made ischemic for 3 hours (n = 6) and reperfused for 10 minutes had increased levels of TXB2 3,450 pg/ml, which was higher than sham rabbit (n = 6) values of 653 pg/ml (p less than 0.05). When introduced into abraded skin chambers placed on the dorsum of other normal rabbits (n = 6), this ischemic plasma induced 1,000 pg/ml of new TX synthesis and diapedesis of 1,235 PMN/mm3. The total TX concentration and PMN accumulations in blister fluid were correlated (r = 0.88, p less than ...
Purpose: : Recent studies have reported that connective tissue growth factor(CTGF) biochemically binds to fibronectin(FN) and promotes cell activity on various cells. In this study, we investigate the interaction between CTGF and FN for corneal epithelial cell attachment and migration. Methods: : A human corneal epithelial cells (HCEC) line that had been established by SV40-adenovirus recombinant vector was used in this study. CTGF-specific shRNA was synthesized and transfected into HCECs. The transfected cells were evaluated by western blot analysis to examine CTGF and FN production. For cell attachment assay, HCECs were either incubated with or without CTGF and were incubated in a FN-coated well or a BSA-coated well. After 45 minutes, the numbers of cells attached to the wells were counted. Another experiment was conducted to determine the interaction between CTGF and FN for epithelial cell migration. Rabbit cornea blocks were incubated with CTGF alone, FN alone or with a combination of both ...
An organized microtubule array is essential for the polarized motility of fibroblasts. Dynamic microtubules closely interact with focal adhesion sites in migrating cells. Here, we examined the effect of focal adhesions on microtubule dynamics. We observed that the probability of microtubule catastrophes (transitions from growth to shrinkage) was seven times higher at focal adhesions than elsewhere. Analysis of the dependence between the microtubule growth rate and catastrophe probability throughout the cytoplasm revealed that a nonspecific (mechanical or spatial) factor provided a minor contribution to the catastrophe induction by decreasing microtubule growth rate at adhesions. Strikingly, at the same growth rate, the probability of catastrophes was significantly higher at adhesions than elsewhere, indicative of a site-specific biochemical trigger. The observed catastrophe induction occurred at adhesion domains containing the scaffolding protein paxillin that has been shown previously to ...
Our purpose was assess the impact of Activated Leucocyte Cell Adhesion Molecule (ALCAM) on Human Vascular Endothelial Cells (HECV), these cell are important in angiogenesis and hence wound healing. HECV line positive for ALCAM were used. Anti-ALCAM transgenes were constructed based on the secondary structure of the ALCAM mRAN. After transfection of HECV cells with the transgene and control vectors, the following cell sublines were created; a control (HECVpEF) endothelial cell line and a ALCAM-knockdown (HECVALCAM/KD) cell line. We then assessed the impact of ALCAM on cellular migration of the endothelial cells by way of electric wounding using Electrical Cell Impedence Sensing (ECIS) zy model. We successfully suppressed the expression of ALCAM in HECV cells by using the anti-ALCAM transgene. HECV rapidly migrated after wounding. It recovered at a rapid pace (0.57/min). Interestingly, after losing ALCAM transcript, the HECVALCAM/KD cells migrated at a substantially reduced rate. Finally, the ...
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab.. ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling.[1]. CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.. Efalizumab acts as an immunosuppressant by binding to ...
Hysteroscopic myomectomy is the referent surgical treatment for submucous myoma. But intrauterine adhesion rate was evaluated about 7 to 15% after this procedure. The investigators hypothetically believe that application of HYALOBARRIER Gel at the end of the procedure, could be reduce the mean intrauterine rate to 50%. Thus, the investigators performed a multicenter (n = 20) prospective study non randomized in 220 patients with submucous myoma , 3 cm of diameter, evaluated by preoperative ultrasound. The investigators prefer this study design, because the principal reason is the number of enrolled patient were more 200 patients in each group with a double blind randomized study. Now, in all patients, after hysteroscopic myomectomy which performed with a same technique in each center (bipolar coagulation and physiologic serum), a diagnostic hysteroscopy was performed at 2 month to determinate the existence of intrauterine adhesion. Secondary end points were in this study the tolerance and side ...
During the allergic reaction mucosal T cells are activated and a local increase in numbers occurs. In peripheral blood, a concomitant T cell activation and switch towards memory phenotype appears. E-selectin, intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 were studied in nasal mucosal biopsies taken during a time-course provocation study, including patients with seasonal allergic rhinitis and healthy controls. Allergic patients were also studied during the natural pollen season with particular attention to the influence of local corticosteroid treatment. Before provocation allergic patients and controls did not differ concerning the expression of endothelial adhesion molecules. However, the epithelial ICAM-1 expression was increased among allergics (P , 0.05). Repetitive allergen provocation induces an increased endothelial expression of VCAM-1 in allergic patients (P , 0.01). Similarly, VCAM-1 expression was increased during the natural pollen season (P , ...
Dynamic regulation of cell-cell adhesion by the coordinated formation and dissolution of E-cadherin-based adherens junctions is crucial for tissue homeostasis. The actin-binding protein cortactin interacts with E-cadherin and enables F-actin accumulation at adherens junctions. Here, we were interested to study the broader functional interactions of cortactin in adhesion complexes. In line with literature, we demonstrate that cortactin binds to E-cadherin, and that a posttranslational modification of cortactin, RhoA-induced phosphorylation by protein kinase D1 (PKD1;also known as PRKD1) at S298, impairs adherens junction assembly and supports their dissolution. Two new S298-phosphorylation-dependent interactions were also identified, namely, that phosphorylation of cortactin decreases its interaction with beta-catenin and the actin-binding protein vinculin. In addition, binding of vinculin to beta-catenin, as well as linkage of vinculin to F-actin, are also significantly compromised upon ...
Classical cadherins mediate Ca2+-dependent intercellular adhesion and are essential for tissue morphogenesis and maintenance. They are key components of adherens junctions (AJs). In vitro studies in simple epithelial cells indicated an essential role for E-cadherin not only in the formation of AJs but also other intercellular contacts, such as desmosomes and tight junctions. In contrast, in vivo tissue specific knockout studies did not reveal a necessity of E-cadherin in the formation of intercellular junctions, raising the question if classical cadherins are necessary or if other classical cadherins can compensate for the loss of E-cadherin. Therefore, the aim of this thesis was to ask how E-cadherin regulates tight junctions and if E-cadherin has a specific function in the formation of tight junctions. In addition, the question was asked if classical cadherin function is necessary for the formation of other intercellular contacts, such as desmosomes. Using primary keratinocytes as a model for ...
The objectives of this research were to better characterize the protein signaling complexes that form in response to spermatozoa binding to the bovine oocyte vitelline membrane and to elucidate their potential involvement in oocyte activation. Integrins located on the vitelline membrane of bovine oocytes have been implicated in mediating the sperm-oocyte interaction. Anti-integrin function blocking antibodies and immunofluorescence were utilized in order to reveal that the αV and β1 integrin subunits are essential for fertilization in the bovine and could form the integrin heterodimer involved in the sperm-oocyte interaction. Focal adhesion kinase is localized to focal adhesions and is a key component of signal transduction pathways mediated by integrins. The presence of focal adhesion kinase in bovine oocytes was verified by real-time polymerase chain reaction and immunoprecipitation and the localization of focal adhesion kinase at the site of sperm binding to the oocyte plasma membrane was verified
The overall goal of this research is to elucidate the effects of stiffness on the activation of pulmonary endothelial cells by inflammatory cytokines. The hypothesis tested is that increasing matrix stiffness in the (patho) physiological range will exacerbate the response of cultured endothelial cells to inflammatory stimuli. To test this hypothesis, we are culturing control and TNF-a stimulated rat lung microvascular endothelial cells (RLMVECs) on hydrogels with tunable stiffnesses of 5, 20, and 45 kPa (measured using compression testing), modeling the stiffness of healthy, intermediate and fibrotic lung tissue respectively. The cellular readout was assessed through RT-qPCR, microscopy, and monocyte adhesion for basal expression and upregulation of vascular cell adhesion molecule-1 (VCAM-1) in quiescent and TNF-a stimulated cultured endothelial cell. This model of microvascular pulmonary inflammation, mimicking a normal, intermediate, and fibrotic lung, is aimed at establishing a correlation ...
Platelet adhesion on von Willebrand factor (vWf) requires the co-ordinated adhesive function of glycoprotein Ib/V/IX and integrin αIIbβ3. Recent evidence [Nesbitt, Kulkarni, Giuliano, Gonclaves, Dopheide, Yap, Harper, Salem and Jackson (2002) J. Biol. Chem. 277, 2965-2972] suggests that outside-in signals from both receptors play important roles in regulating platelet-adhesion dynamics under flow. In the present study, we have examined the mechanisms utilized by protein kinase C (PKC) to promote irreversible platelet adhesion on vWf. We demonstrate that PKC is primarily activated downstream of integrin αIIbβ3, not glycoprotein Ib, during platelet adhesion on vWf. This integrin αIIbβ3-dependent PKC activation establishes a positive-feedback loop that promotes further integrin αIIbβ3 activation, calcium mobilization and firm platelet adhesion. This feedback loop appears to be most relevant at relatively low cytosolic calcium concentrations (mean Δ[Ca2+]i~100 nM) as artificially elevating ...
Abstract. Background: Periodontal regeneration is dependent on the uninterrupted adhesion, maturation and absorption of fibrin clots to a periodontally compromised root surface. The modification of the root surface with different agents has been used for better fibrin clot formation and blood cell attachment. It is known that Er:YAG laser application on dentin removes the smear layer succesfully.. Aim: The aim of this study is to observe blood cell attachment and fibrin network formation following ER:YAG laser irradiation on periodontally compromised root surfaces in comparison to chemical root conditioning techniques in vitro.. Materials and methods: 40 dentin blocks prepared from freshly extracted periodontally compromised hopeless teeth. Specimens were divided in 5 groups; those applied with PBS, EDTA, Citric acid and Er:YAG. They were further divided into two groups: those which had received these applications, and the control group. The specimens were evaluated with scanning electron ...
TY - JOUR. T1 - PTH-related protein enhances LoVo colon cancer cell proliferation, adhesion, and integrin expression. AU - Shen, Xiaoli. AU - Falzon, Miriam. PY - 2005/2/15. Y1 - 2005/2/15. N2 - Parathyroid hormone-related protein (PTHrP) has been localized in human colon cancer tissue and cell lines. Tumor cell adhesion to extracellular matrix (ECM) proteins plays a major role in the invasion and metastasis of tumor cells, and is mediated via integrin subunits. The LoVo human colon cancer cell line was used as a model system to study the effects of PTHrP on cell proliferation and adhesion to ECM proteins found in normal liver. Clones of LoVo cells engineered to overexpress PTHrP by stable transfection with a PTHrP cDNA showed enhanced cell proliferation vs. control (empty vector-transfected) cells. PTHrP-overexpressing cells also showed significantly higher adhesion to collagen type I, fibronectin, and laminin, and enhanced expression of the ∀2, ∀5, ∀6, ∃1 and ∃4 integrin subunits. ...
Desmosomes are molecular complexes of cell adhesion proteins and linking proteins that attach the cell surface adhesion proteins to intracellularkeratin cytoskeletal filaments.. The cell adhesion proteins of the desmosome, desmoglein and desmocollin, are members of the cadherin family of cell adhesion molecules. They aretransmembrane proteins that bridge the space between adjacent epithelial cellsby way of homophilic binding of their extracellular domains to other desmosomal cadherins on the adjacent cell. Both have five extracellular domains, and have calcium-binding motifs.. The extracellular domain of the desmosome is called the Extracellular Core Domain (ECD) or the Desmoglea, and is bisected by an electron-dense midline where the desmoglein and desmocollin proteins bind to each other. These proteins can bind in a W, S, or λ manner.. On the cytoplasmic side of the plasma membrane, there are two dense structures called the Outer Dense Plaque (ODP) and the Inner Dense Plaque (IDP). These are ...
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Tight junctions (TJs) are electron‐dense structures connecting the lateral membranes of adjacent epithelial or endothelial cells. They exert adhesive properties and stabilize homophilic cell-cell binding. TJs serve a dual role in controlling paracellular permeability and in maintaining cell polarity. These junctional structures are particularly well developed in regions of the vascular tree where permeability has to be restricted, e.g. in the brain microvasculature and in large arteries (Mitic and Anderson, 1998; Stevenson and Keon, 1998; Dejana et al., 2000). Little is known about the molecular basis for the intercellular adhesion of TJs, despite their eminent role in organ functioning. Different transmembrane proteins have been found to be located specifically at TJs. Occludin and the claudin family belong to the class of tetra‐span transmembrane proteins (Furuse et al., 1993, 1998a,b). Occludin is dispensable for TJ organization and adhesive properties (Saitou et al., 1998). In contrast, ...
[54 Pages Report] Check for Discount on Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (Carcinoembryonic Antigen or CEA or Meconium Antigen 100 or CD66e or CEACAM5) - Pipeline Review, H1 2016 report by Global Markets Direct. Global Markets Directs, Carcinoembryonic Antigen-Related Cell Adhesion Molecule...
Human intrahepatic biliary epithelial cells were isolated from the livers of patients with primary biliary cirrhosis and from normal livers and established in primary culture. The in vitro expression of intercellular adhesion molecule-1, HLA class I, and HLA class II on biliary epithelial cells was studied in response to tumour necrosis factor-alpha (0-500 U/ml), interferon-gamma (0-500 U/ml), and interleukin-1 (0-5 U/ml) by immunohistochemical staining and a semiquantitative scoring system validated by spectrophotometry and previously validated by laser confocal microscopy. The non-stimulated expression of intercellular adhesion molecule-1 and HLA class II was higher on cells derived from the primary biliary cirrhosis liver than on cells from normal liver, a difference not seen with HLA class I expression. A statistically significant increase in intercellular adhesion molecule-1 expression was seen with all three cytokines in cells derived from both primary biliary cirrhosis and normal liver. ...
Title:MiR-138 and MiR-135 Directly Target Focal Adhesion Kinase, Inhibit Cell Invasion, and Increase Sensitivity to Chemotherapy in Cancer Cells. VOLUME: 14 ISSUE: 1. Author(s):Vita M. Golubovskaya, Brittany Sumbler, Baotran Ho, Michael Yemma and William G. Cance. Affiliation:Department of Surgical Oncology, Roswell Park, Cancer Institute, Buffalo, NY 14263, USA.. Keywords:Cancer, expression, Focal Adhesion Kinase, invasion, microRNA, tumor.. Abstract:Focal Adhesion Kinase is a 125 kDa non-receptor kinase and overexpressed in many types of tumors. Recently, short noncoding RNAs, called microRNAs have been discovered as regulators of gene expression mainly through binding to the untranslated region (UTR) of mRNA. In this report we show that MiR-138 and MiR-135 down-regulated FAK expression in cancer cells. MiR-138 and MiR-135 inhibited FAK protein expression in different cancer cell lines. The computer analysis of 3FAK-untranslated region (FAKUTR) identified one conserved MiR-138 binding site ...
Entyvio, an integrin receptor antagonist, is a humanized monoclonal antibody that specifically binds to the alpha4beta7 integrin and blocks the interaction of alpha4beta7 integrin with mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and inhibits the migration of memory T-lymphocytes across the endothelium into inflamed gastrointestinal parenchymal tissue. Entyvio does not bind to or inhibit function of the alpha4beta1 and alpha E beta 7 integrins and does not antagonize the interaction of alpha4 integrins with vascular cell adhesion molecule-1 (VCAM-1). The alpha4beta7 integrin is expressed on the surface of a discrete subset of memory T-lymphocytes that preferentially migrate into the gastrointestinal tract. MAdCAM-1 is mainly expressed on gut endothelial cells and plays a critical role in the homing of T-lymphocytes to gut lymph tissue. The interaction of the alpha4beta7 integrin with MAdCAM-1 has been implicated as an important contributor to the chronic inflammation that is a hallmark ...
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The bacterial strains of Rhodococcus sp. S3E2 and Rhodococcus sp. S3E3 were selected for adhesion study on Teflon-like or organosilicon thin films deposited on paper substrate in atmospheric pressure surface barrier discharge. As a carrier gas the nitrogen with small admixture of octafluorocyclobutane or hexamethylenedisiloxane was used. The influence of octafluorocyclobutane and hexamethylenedisiloxane flowrate ratio on later cell adhesion was studied. The cell attachment was evaluated by means of the luminometric measurement of the ATP extracted from adhered cells. The surface properties of deposited layers were investigated by means contact angle measurement and chemical properties of deposited films were studied by means of FTIR spectroscopy. Optical emission spectroscopy was used for investigation of plasma parameters of used plasma ...
Peritoneal adhesions occur in up to 93% of adults after peritoneal trauma during surgery. Most adhesions are asymptomatic but can cause female infertility, small bowel obstruction (SBO) and chronic abdominal pain. Adhesion prophylaxis is needed to reduce the significant morbidity and increased health care costs resulting from peritoneal adhesions. This thesis aims to establish a relevant and reproducible experimental adhesion model to simultaneously study the healing processs and adhesion formation and later to examine whether carbazate-activated polyvinyl alcohol (PVAC), an aldehyde-carbonyl scavenger, can reduce adhesion formation or not; and, in a long-term follow-up, to investigate the incidence of and identify risk factors for adhesive SBO requiring surgical treatment after laparotomy during infancy and to survey the prevalence of self-reported chronic abdominal pain and female infertility. Male Sprague-Dawley rats were subjected to laparotomy, cecal abrasion, and construction of a small ...
Platelet adhesiveness - Wikipedia  Platelet adhesiveness - Wikipedia
Platelet adhesiveness is the adhesion of platelets to other structures. It can be contrasted with platelet aggregation, which ... May 2004). "Assessment of platelet adhesiveness and aggregation in mild acute pancreatitis using the PFA-100 system". JOP. 5 (3 ... Platelet membrane glycoprotein Platelet adhesiveness at the US National Library of Medicine Medical Subject Headings (MeSH) ...
more infohttps://en.wikipedia.org/wiki/Platelet_adhesiveness
Adhesiveness - definition of adhesiveness by The Free Dictionary  Adhesiveness - definition of adhesiveness by The Free Dictionary
adhesiveness synonyms, adhesiveness pronunciation, adhesiveness translation, English dictionary definition of adhesiveness. adj ... Adhesiveness - definition of adhesiveness by The Free Dictionary https://www.thefreedictionary.com/adhesiveness ... adhesiveness. Also found in: Thesaurus, Medical, Legal, Encyclopedia. ad·he·sive. (ăd-hē′sĭv, -zĭv). adj.. 1. Tending to adhere ... adhesiveness - the property of sticking together (as of glue and wood) or the joining of surfaces of different composition; " ...
more infohttps://www.thefreedictionary.com/adhesiveness
Adhesiveness - Biology-Online Dictionary  Adhesiveness - Biology-Online Dictionary
Retrieved from "http://www.biology-online.org/bodict/index.php?title=Adhesiveness&oldid=24337" ...
more infohttp://www.biology-online.org/dictionary/Adhesiveness
T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1.  - PubMed - NCBI  T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. - PubMed - NCBI
T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1.. Dustin ML1, Springer TA. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/2477710?dopt=Abstract
JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila | PNAS  JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila | PNAS
JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila. Enrique ... JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila ... JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila ... JNK and decapentaplegic signaling control adhesiveness and cytoskeleton dynamics during thorax closure in Drosophila ...
more infohttps://www.pnas.org/content/97/14/7888?ijkey=345b9986132d7111d6de9303198d7e8c15d25c76&keytype2=tf_ipsecsha
Effect of a Nonionic Surface-Active Agent on Blood Viscosity and Platelet Adhesiveness | Circulation  Effect of a Nonionic Surface-Active Agent on Blood Viscosity and Platelet Adhesiveness | Circulation
Effect of a Nonionic Surface-Active Agent on Blood Viscosity and Platelet Adhesiveness. FREDERICK L. GROVER, MICHAEL W. HERON, ... Platelet adhesiveness decreased markedly in six patients within ten minutes after intravenous injection. Pluronic F68 has many ... Its potential in the treatment of diseases in which high viscosity or increased platelet adhesiveness are present deserves ... The effects of Pluronic F68, a nonionic surface-active agent, on blood viscosity and platelet adhesiveness during ...
more infohttp://circ.ahajournals.org/content/39/5S1/I-249
Simple method for the estimation of platelet adhesiveness | Journal of Clinical Pathology  Simple method for the estimation of platelet adhesiveness | Journal of Clinical Pathology
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
more infohttp://jcp.bmj.com/content/18/3/384
Buy PDF - Effect of flavonoids on the platelet adhesiveness in repeatedly bred rats  Buy PDF - Effect of flavonoids on the platelet adhesiveness in repeatedly bred rats
Effect of flavonoids on the platelet adhesiveness in repeatedly bred rats ... Platelet adhesiveness the effect of inst centrifugation on the measurement of adhesiveness in platelet rich plasma human. ... Platelet adhesiveness before and following hysterectomy and the effect of VK 744 and Adumbran on platelet adhesiveness. ... Platelet adhesiveness: the effect of centrifugation on the measurement of adhesiveness in platelet-rich plasma. Journal of ...
more infohttps://eurekamag.com/research/005/239/005239382.php
Regulation of the cytoskeleton and the adhesiveness of intestinal epithelial cells by leukotriene D4  Regulation of the cytoskeleton and the adhesiveness of intestinal epithelial cells by leukotriene D4
... Massoumi, Ramin LU (2002 ... Regulation of the cytoskeleton and the adhesiveness of intestinal epithelial cells by leukotriene D4}, year = {2002}, } ...
more infohttps://lup.lub.lu.se/search/publication/464556
Sugar intake, serum insulin and platelet adhesiveness in men with and without peripheral vascular disease | Postgraduate...  Sugar intake, serum insulin and platelet adhesiveness in men with and without peripheral vascular disease | Postgraduate...
Both the level of serum insulin and the adhesiveness of platelets are correlated with sucrose intake in men with peripheral ... Sugar intake, serum insulin and platelet adhesiveness in men with and without peripheral vascular disease ... Sugar intake, serum insulin and platelet adhesiveness in men with and without peripheral vascular disease ...
more infohttp://pmj.bmj.com/content/45/527/608
Carvedilol Inhibits Tumor Necrosis Factor-α-Induced Endothelial Transcription Factor Activation, Adhesion Molecule Expression,...  Carvedilol Inhibits Tumor Necrosis Factor-α-Induced Endothelial Transcription Factor Activation, Adhesion Molecule Expression,...
Carvedilol Inhibited the Adhesiveness of MNCs to TNF-α-Stimulated HAECs. HAECs were pretreated with 10 μmol/L carvedilol, 10 ... Coincubated with prazosin and 10 or 50 μmol/L of propranolol did not inhibit MNC adhesiveness to HAECs (Figure 1a to 1i). The ... Figure 1. The adhesiveness of TNF-α-stimulated HAECs to isolated human MNCs. HAECs were treated for 18 hours with 10 μmol/L ... However, both could inhibit endothelial adhesiveness to human MNCs in a similar degree. Taken together, VCAM-1 may play a ...
more infohttp://atvb.ahajournals.org/content/24/11/2075
Adrenomedullin Reduces VEGF-Induced Endothelial Adhesion Molecules and Adhesiveness Through a Phosphatidylinositol 3-Kinase...  Adrenomedullin Reduces VEGF-Induced Endothelial Adhesion Molecules and Adhesiveness Through a Phosphatidylinositol 3'-Kinase...
Adrenomedullin Reduces VEGF-Induced Endothelial Adhesion Molecules and Adhesiveness Through a Phosphatidylinositol 3-Kinase ... Adrenomedullin Reduces VEGF-Induced Endothelial Adhesion Molecules and Adhesiveness Through a Phosphatidylinositol 3-Kinase ... Adrenomedullin Reduces VEGF-Induced Endothelial Adhesion Molecules and Adhesiveness Through a Phosphatidylinositol 3-Kinase ... Adrenomedullin Reduces VEGF-Induced Endothelial Adhesion Molecules and Adhesiveness Through a Phosphatidylinositol 3-Kinase ...
more infohttp://atvb.ahajournals.org/content/early/2003/06/12/01.ATV.0000081740.65173.D1
ICAM-4 and CD36 are implicated in the abnormal adhesiveness to endothelium of sickle cell SAD mouse erythrocytes | Haematologica  ICAM-4 and CD36 are implicated in the abnormal adhesiveness to endothelium of sickle cell SAD mouse erythrocytes | Haematologica
The phosphorylation state of ICAM-4 and CD36 is probably not involved in the over-adhesiveness of SAD erythrocytes. ... ICAM-4 and CD36 are implicated in the abnormal adhesiveness to endothelium of sickle cell SAD mouse erythrocytes ... Background and objectives Abnormal adhesiveness of red blood cells to endothelium has been implicated in vasoocclusive crisis ... ICAM-4 and CD36 are implicated in the abnormal adhesiveness to endothelium of sickle cell SAD mouse erythrocytes ...
more infohttp://www.haematologica.org/content/early/2009/12/16/haematol.2009.017392
Increased leucocyte adhesiveness/aggregation is a most useful indicator of disease activity in patients with inflammatory bowel...  Increased leucocyte adhesiveness/aggregation is a most useful indicator of disease activity in patients with inflammatory bowel...
Increased leucocyte adhesiveness/aggregation is a most useful indicator of disease activity in patients with inflammatory bowel ... Increased leucocyte adhesiveness/aggregation is a most useful indicator of disease activity in patients with inflammatory bowel ... The erythrocyte sedimentation rate, platelet and white blood cell count, C reactive protein, and the leucocyte adhesiveness/ ...
more infohttps://gut.bmj.com/content/37/1/77
The effect of dietary sucrose on blood lipids, serum insulin, platelet adhesiveness and body weight in human volunteers |...  The effect of dietary sucrose on blood lipids, serum insulin, platelet adhesiveness and body weight in human volunteers |...
The effect of dietary sucrose on blood lipids, serum insulin, platelet adhesiveness and body weight in human volunteers ... The effect of dietary sucrose on blood lipids, serum insulin, platelet adhesiveness and body weight in human volunteers ... The effect of dietary sucrose on blood lipids, serum insulin, platelet adhesiveness and body weight in human volunteers ...
more infohttps://pmj.bmj.com/content/45/527/602.citation-tools
In vitro adhesiveness and biotype of Gardnerella vaginalis strains in relation to the occurrence of clue cells in vaginal...  In vitro adhesiveness and biotype of Gardnerella vaginalis strains in relation to the occurrence of clue cells in vaginal...
In vitro adhesiveness and biotype of Gardnerella vaginalis strains in relation to the occurrence of clue cells in vaginal ... In vitro adhesiveness and biotype of Gardnerella vaginalis strains in relation to the occurrence of clue cells in vaginal ...
more infohttp://sti.bmj.com/content/63/1/47
Adhesiveness synonyms, adhesiveness antonyms - FreeThesaurus.com  Adhesiveness synonyms, adhesiveness antonyms - FreeThesaurus.com
Antonyms for adhesiveness. 3 synonyms for adhesiveness: adherence, adhesion, bond. What are synonyms for adhesiveness? ... Synonyms for adhesiveness. the property of sticking together (as of glue and wood) or the joining of surfaces of different ... SEM analysis of the cell matrix samples showed that the apparent selective adhesiveness of these localized area may be due to ... Caption: Electrostatic forces play a role in gecko adhesiveness, a new study finds, despite 80 years of belief to the contrary. ...
more infohttps://www.freethesaurus.com/adhesiveness
Mimidis K, et al. Assessment of Platelet Adhesiveness and Aggregation in Mild Acute Pancreatitis Using the PFA-100TM System....  Mimidis K, et al. Assessment of Platelet Adhesiveness and Aggregation in Mild Acute Pancreatitis Using the PFA-100TM System....
Assessment of Platelet Adhesiveness and Aggregation in Mild Acute Pancreatitis Using the PFA-100TM System ... This confirms increased platelet adhesiveness and aggregation [13] in the early stages of the inflammatory process of acute ... Using this method, we demonstrated that, in the early stages of acute pancreatitis, platelet adhesiveness and aggregation is ... a platelet function analyzer has never been used before to evaluate augmented platelet adhesiveness/aggregation and ...
more infohttp://www.joplink.net/prev/200405/08.html
Von willebrand factor increases endothelial cell adhesiveness for human mesenchymal stem cells by activating p38 mitogen...  Von willebrand factor increases endothelial cell adhesiveness for human mesenchymal stem cells by activating p38 mitogen...
Previously we have shown that adhesiveness of endothelial cells for mesenchymal stem cells correlates with the inhibition of ... We hypothesized that von Willebrand factor is an auto/paracrine regulator of endothelial cell adhesiveness and studied the ... were used to evaluate the role of mitogen-activated protein kinases in the regulation of endothelial cell adhesiveness for ... of p38 MAPK in endothelial cells by von Willebrand factor is responsible for the regulation of endothelial cell adhesiveness ...
more infohttps://stemcellres.biomedcentral.com/articles/10.1186/scrt35
  • Hardness (maximum force required in the first compression of the sample in g), cohesiveness (ratio between the positive area of the curve during the second and the first compression, dimensionless), elasticity (ratio between the time of the second cycle and the first cycle, dimensionless) and adhesiveness parameters (negative area of the force after the first compression, in gs) were evaluated. (thefreedictionary.com)
  • The research also showed that the content of crude fiber positively correlated with shear force and cutting power, but negatively correlated with hardness, adhesiveness and flexibility. (thefreedictionary.com)
  • Under physiologic conditions, we compared the adhesiveness of CD4+ and CD8+ lymphocytes from nontreated patients with acute, relapsing-remitting multiple sclerosis (RRMS) and from healthy donors. (unimi.it)
  • SEM analysis of the cell matrix samples showed that the apparent selective adhesiveness of these localized area may be due to processing or natural variations in the collagen layer. (freethesaurus.com)
  • The Solbin series is a modified copolymer resin combining the toughness of vinyl chloride with the strong adhesiveness and plasticity of vinyl acetate. (freethesaurus.com)
  • Caption: Electrostatic forces play a role in gecko adhesiveness , a new study finds, despite 80 years of belief to the contrary. (freethesaurus.com)
  • In this study, we investigated the inhibitory effects of curcumin on ICAM-1 expression and monocyte adhesiveness as well as its underlying action mechanism in the TNF-α-stimulated keratinocytes. (kpubs.org)