5'-Adenylic acid, monoanhydride with imidodiphosphoric acid. An analog of ATP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It is a potent competitive inhibitor of soluble and membrane-bound mitochondrial ATPase and also inhibits ATP-dependent reactions of oxidative phosphorylation.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.
The rate dynamics in chemical or physical systems.
An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 4.6.1.1.
Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.
A source of inorganic fluoride which is used topically to prevent dental caries.

Membrane deinsertion of SecA underlying proton motive force-dependent stimulation of protein translocation. (1/521)

The proton motive force (PMF) renders protein translocation across the Escherichia coli membrane highly efficient, although the underlying mechanism has not been clarified. The membrane insertion and deinsertion of SecA coupled to ATP binding and hydrolysis, respectively, are thought to drive the translocation. We report here that PMF significantly decreases the level of membrane-inserted SecA. The prlA4 mutation of SecY, which causes efficient protein translocation in the absence of PMF, was found to reduce the membrane-inserted SecA irrespective of the presence or absence of PMF. The PMF-dependent decrease in the membrane-inserted SecA caused an increase in the amount of SecA released into the extra-membrane milieu, indicating that PMF deinserts SecA from the membrane. The PMF-dependent deinsertion reduced the amount of SecA required for maximal translocation activity. Neither ATP hydrolysis nor exchange with external SecA was required for the PMF-dependent deinsertion of SecA. These results indicate that the SecA deinsertion is a limiting step of protein translocation and is accelerated by PMF, efficient protein translocation thereby being caused in the presence of PMF.  (+info)

Dual actions of the metabolic inhibitor, sodium azide on K(ATP) channel currents in the rat CRI-G1 insulinoma cell line. (2/521)

1. The effects of various inhibitors of the mitochondrial electron transport chain on the activity of ATP-sensitive K+ channels were examined in the Cambridge rat insulinoma G1 (CRI-G1) cell line using a combination of whole cell and single channel recording techniques. 2. Whole cell current clamp recordings, with 5 mM ATP in the pipette, demonstrate that the mitochondrial uncoupler sodium azide (3 mM) rapidly hyperpolarizes CRI-G1 cells with a concomitant increase in K+ conductance. This is due to activation of K(ATP) channels as the sulphonylurea tolbutamide (100 microM) completely reversed the actions of azide. Other inhibitors of the mitochondrial electron transport chain, rotenone (10 microM) or oligomycin (2 microM) did not hyperpolarize CRI-G1 cells or increase K+ conductance. 3. In cell-attached recordings, bath application of 3 mM sodium azide (in the absence of glucose) resulted in a rapid increase in K(ATP) channel activity, an action readily reversible by tolbutamide (100 microM). Application of sodium azide (3 mM), in the presence of Mg-ATP, to the intracellular surface of excised inside-out patches also increased K(ATP) channel activity, in a reversible manner. 4. In contrast, rotenone (10 microM) or oligomycin (2 microM) did not increase K(ATP) channel activity in either cell-attached, in the absence of glucose, or inside-out membrane patch recordings. 5. Addition of sodium azide (3 mM) to the intracellular surface of inside-out membrane patches in the presence of Mg-free ATP or the non-hydrolysable analogue 5'-adenylylimidodiphosphate (AMP-PNP) inhibited, rather than increased, K(ATP) channel activity. 6. In conclusion, sodium azide, but not rotenone or oligomycin, directly activates K(ATP) channels in CRI-G1 insulin secreting cells. This action of azide is similar to that reported previously for diazoxide.  (+info)

ATP inhibition of a mouse brain large-conductance K+ (mslo) channel variant by a mechanism independent of protein phosphorylation. (3/521)

1. We investigated the effect of ATP in the regulation of two closely related cloned mouse brain large conductance calcium- and voltage-activated potassium (BK) channel alpha-subunit variants, expressed in human embryonic kidney (HEK 293) cells, using the excised inside-out configuration of the patch-clamp technique. 2. The mB2 BK channel alpha-subunit variant expressed alone was potently inhibited by application of ATP to the intracellular surface of the patch with an IC50 of 30 microM. The effect of ATP was largely independent of protein phosphorylation events as the effect of ATP was mimicked by the non-hydrolysable analogue 5'-adenylylimidodiphosphate (AMP-PNP) and the inhibitory effect of ATPgammaS was reversible. 3. In contrast, under identical conditions, direct nucleotide inhibition was not observed in the closely related mouse brain BK channel alpha-subunit variant mbr5. Furthermore, direct nucleotide regulation was not observed when mB2 was functionally coupled to regulatory beta-subunits. 4. These data suggest that the mB2 alpha-subunit splice variant could provide a dynamic link between cellular metabolism and cell excitability.  (+info)

ATP counteracts the rundown of gap junctional channels of rat ventricular myocytes by promoting protein phosphorylation. (4/521)

1. The degree of cell-to-cell coupling between ventricular myocytes of neonatal rats appeared well preserved when studied in the perforated version of the patch clamp technique or, in double whole-cell conditions, when ATP was present in the patch pipette solution. In contrast, when ATP was omitted, the amplitude of junctional current rapidly declined (rundown). 2. To examine the mechanism(s) of ATP action, an 'internal perfusion technique' was adapted to dual patch clamp conditions, and reintroduction of ATP partially reversed the rundown of junctional channels. 3. Cell-to-cell communication was not preserved by a non-hydrolysable ATP analogue (5'-adenylimidodiphosphate, AMP-PNP), indicating that the effect most probably did not involve direct interaction of ATP with the channel-forming proteins. 4. An ATP analogue supporting protein phosphorylation but not active transport processes (adenosine 5'-O-(3-thiotriphosphate), ATPgammaS) maintained normal intercellular communication, suggesting that the effect was due to kinase activity rather than to altered intracellular Ca2+. 5. A broad spectrum inhibitor of endogenous serine/threonine protein kinases (H7) reversibly reduced the intercellular coupling. A non-specific exogenous protein phosphatase (alkaline phosphatase) mimicked the effects of ATP deprivation. The non-specific inhibition of endogenous protein phosphatases resulted in the preservation of substantial cell-to-cell communication in ATP-free conditions. 6. The activity of gap junctional channels appears to require both the presence of ATP and protein kinase activity to counteract the tonic activity of endogenous phosphatase(s).  (+info)

Analysis of DNA cleavage by reverse gyrase from Sulfolobus shibatae B12. (5/521)

Reverse gyrase is a type I-5' topoisomerase, which catalyzes a positive DNA supercoiling reaction in vitro. To ascertain how this reaction takes places, we looked at the DNA sequences recognized by reverse gyrase. We used linear DNA fragments of its preferred substrate, the viral SSV1 DNA, which has been shown to be positively supercoiled in vivo. The Sulfolobus shibatae B12 strain, an SSV1 virus host, was chosen for production of reverse gyrase. This naturally occurring system (SSV1 DNA-S. shibatae reverse gyrase) allowed us to determine which SSV1 DNA sequences are bound and cleaved by the enzyme with particularly high selectivity. We show that the presence of ATP decreases the number of cleaved complexes obtained whereas the non-hydrolyzable ATP analog adenosine 5'-[beta, gamma-imido]triphosphate increases it without changing the sequence specificity.  (+info)

Motile properties of the kinesin-related Cin8p spindle motor extracted from Saccharomyces cerevisiae cells. (6/521)

We have developed microtubule binding and motility assays for Cin8p, a kinesin-related mitotic spindle motor protein from Saccharomyces cerevisiae. The methods examine Cin8p rapidly purified from crude yeast cell extracts. We created a recombinant form of CIN8 that fused the biotin carrying polypeptide from yeast pyruvate carboxylase to the carboxyl terminus of Cin8p. This form was biotinated in yeast cells and provided Cin8p activity in vivo. Avidin-coated glass surfaces were used to specifically bind biotinated Cin8p from crude extracts. Microtubules bound to the Cin8p-coated surfaces and moved at 3.4 +/- 0.5 micrometer/min in the presence of ATP. Force production by Cin8p was directed toward the plus ends of microtubules. A mutation affecting the microtubule-binding site within the motor domain (cin8-F467A) decreased Cin8p's ability to bind microtubules to the glass surface by >10-fold, but reduced gliding velocity by only 35%. The cin8-3 mutant form, affecting the alpha2 helix of the motor domain, caused a moderate defect in microtubule binding, but motility was severely affected. cin8-F467A cells, but not cin8-3 cells, were greatly impaired in bipolar spindle forming ability. We conclude that microtubule binding by Cin8p is more important than motility for proper spindle formation.  (+info)

Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism. (7/521)

We have determined two different structures of PcrA DNA helicase complexed with the same single strand tailed DNA duplex, providing snapshots of different steps on the catalytic pathway. One of the structures is of a complex with a nonhydrolyzable analog of ATP and is thus a "substrate" complex. The other structure contains a bound sulphate ion that sits in a position equivalent to that occupied by the phosphate ion produced after ATP hydrolysis, thereby mimicking a "product" complex. In both complexes, the protein is monomeric. Large and distinct conformational changes occur on binding DNA and the nucleotide cofactor. Taken together, these structures provide evidence against an "active rolling" model for helicase action but are instead consistent with an "inchworm" mechanism.  (+info)

Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair. (8/521)

The MutL DNA mismatch repair protein has recently been shown to be an ATPase and to belong to an emerging ATPase superfamily that includes DNA topoisomerase II and Hsp90. We report here the crystal structures of a 40 kDa ATPase fragment of E. coli MutL (LN40) complexed with a substrate analog, ADPnP, and with product ADP. More than 60 residues that are disordered in the apoprotein structure become ordered and contribute to both ADPnP binding and dimerization of LN40. Hydrolysis of ATP, signified by subsequent release of the gamma-phosphate, releases two key loops and leads to dissociation of the LN40 dimer. Dimerization of the LN40 region is required for and is the rate-limiting step in ATP hydrolysis by MutL. The ATPase activity of MutL is stimulated by DNA and likely acts as a switch to coordinate DNA mismatch repair.  (+info)

1CDK: Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).
In the previously determined structure of mitochondrial F1-ATPase determined with crystals grown in the presence of adenylyl-imidodiphosphate (AMP-PNP) and ADP, the three catalytic beta-subunits have different conformations and nucleotide occupancies. AMP-PNP and ADP are bound to subunits beta TP and beta DP, respectively, and the third beta-subunit (beta E) has no bound nucleotide. The efrapeptins are a closely related family of modified linear peptides containing 15 amino acids that inhibit both ATP synthesis and hydrolysis by binding to the F1 catalytic domain of F1F0-ATP synthase. In crystals of F1-ATPase grown in the presence of both nucleotides and inhibitor, efrapeptin is bound to a unique site in the central cavity of the enzyme. Its binding is associated with small structural changes in side chains of F1-ATPase around the binding pocket. Efrapeptin makes hydrophobic contacts with the alpha-helical structure in the gamma-subunit, which traverses the cavity, and with subunit beta E and ...
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Sodium atom in PDB 1nhj: Crystal Structure of N-Terminal 40KD Mutl/A100P Mutant Protein Complex With Adpnp and One Sodium
TY - JOUR. T1 - Characterization of myosin V binding to brain vesicles. AU - Miller, Kyle E.. AU - Sheetz, Michael. PY - 2000/1/28. Y1 - 2000/1/28. N2 - Myosin II and V are important for the generation and segregation of subcellular compartments. We observed that vesicular myosin II and V were associated with the protein scaffolding of a common subset of vesicles by density sedimentation, electron microscopy, and immunofluorescence. Solubilization of either myosin II or V was caused by polyphosphates with the following efficacy at 10 mM: for myosin II ATP-Mg2+ = ATP = AMP-PNP (5- adenylyl imidodiphosphate) , pyrophosphate = tripolyphosphate ,, tetrapolyphosphate = ADP , cAMP = Mg2+; and for myosin V pyrophosphate = tripolyphosphate , ATP-Mg2+ = ATP = AMP-PNP ,, ADP = tetrapolyphosphate , cAMP = Mg2+. Consequently, we suggest solubilization was not an effect of phosphorylation, hydrolysis, or disassociation of myosin from actin filaments. Scatchard analysis of myosin V binding to stripped dense ...
The mitochondrial pool of Hsp90 and its mitochondrial paralog, TRAP1, suppresses cell death and reprograms energy metabolism in cancer cells; therefore, Hsp90 and TRAP1 have been suggested as target proteins for anticancer drug development. Here, we report that the actual target protein in cancer cell mitochondria is TRAP1, not Hsp90, and current Hsp90 inhibitors cannot effectively inactivate TRAP1 due to insufficient accumulation in the mitochondria. To develop mitochondrial TRAP1 inhibitors, we determined the crystal structures of human TRAP1 complexed with Hsp90 inhibitors. The isopropyl amine of the Hsp90 inhibitor PU-H71 was replaced with the mitochondria-targeting moiety triphenylphosphonium to produce SMTIN-P01. SMTIN-P01 showed a different mode of action from the non-targeted PU-H71, as well as much improved cytotoxicity to cancer cells. In addition, we determined the structure of a TRAP1-adenylyl-imidodiphosphate (AMP-PNP) complex. Based on comparative analysis of TRAP1 structures, we ...
The properties of stretch-activated K+ channels in the membrane of loach (Misgurnus fossilis) embryos were studied using the patch-clamp technique. It was found that in the early stages of embryogenesis (2-256 cells) the stretch sensitivity of stretch-activated (SA) channels changes dramatically during the cell cleavage cycle. At the beginning of interphase the stretch sensitivity of SA channels and the probability of being in the open state (P0) were minimal, whereas at prometaphase they were increased 10-100-fold. Application of ATP to the cytoplasmic surface of excised inside-out patches induced a reversible increase in resting P0 and of stretch sensitivity of the SA channels in 50% of the patches, but the non-hydrolysable analogue of ATP, 5-adenylylimidodiphosphate (AMP-PNP), was not effective. Phosphatase inhibitors (orthovanadate and para-nitrophenyl phosphate) prolonged the effect of ATP. Combined application of ATP, cAMP and cAMP-dependent protein kinase (PK) induced a reversible ...
Thawed, combined with an excess of porcine microtubules and 1 mM AMPPNP, and centrifuged at 100,0006g for 15 minutes at room temperature. 5 mM ATP and 200 mM
Nhà Nhập Khẩu chính hãng và phân phối độc quyền Hammer Nutrition, Ultimate Nutrition, Elite Labs USA và Go-Fit tại Việt Nam, Cambodia và Myanmar.
BR-4935: cardiotonic; a non-adenosine analog adenosine1-receptor agonist with a substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyrine
1BWF: Crystal structures of Escherichia coli glycerol kinase variant S58-->W in complex with nonhydrolyzable ATP analogues reveal a putative active conformation of the enzyme as a result of domain motion.
Sản phẩm Pre Ampli hifi mới, chính hãng được phân phối và bán tại Audiohanoi với giá tốt nhất thị trường hiện nay.,Pre-amplifiers Hi-fi,Showroom Audiohanoi - Đại lý phân...
Sản phẩm Pre Ampli hifi mới, chính hãng được phân phối và bán tại Audiohanoi với giá tốt nhất thị trường hiện nay.,Pre-amplifiers Hi-fi,Showroom Audiohanoi - Đại lý phân...
TY - JOUR. T1 - Variably modulated gating of the 26S proteasome by ATP and polyubiquitin. AU - Li, Xiaohua. AU - DeMartino, George N.. PY - 2009/8/1. Y1 - 2009/8/1. N2 - The 26S proteasome is a 2500 kDa protease complex that degrades polyubiquitylated proteins by a mechanism that requires ATP hydrolysis. It also degrades short non-ubiquitylated peptides and certain unstructured proteins by an energy-independent mechanism that requires bound ATP to maintain its component subcomplexes, the 20S proteasome and PA700, in a functionally assembled state. Proteolysis of both types of substrate requires PA700-induced opening of reversible gates at substrate-access pores of the 20S proteasome. In the present study we demonstrate that the rate of peptide substrate hydrolysis, a functional monitor of gate opening, is regulated variably by multiple effectors. ATPγ S (adenosine 5′-[γ -thio]triphosphate) and other non-hydrolysable ATP analogues increased peptide substrate hydrolysis by intact 26S ...
In the presence of DNA damage, the protein kinase Chk1 can effect cell cycle arrest. Chen et al. determined the crystal structure of the Chk1 kinase domain (Chk1KD), and have uncovered some of its regulatory mechanisms. In the presence or absence of the nonhydrolyzable analog AMP-PNP, no conformational change was observed in the Chk1KD ATP binding site, catalytic residues, or activation loop. Therefore, the conformation of Chk1KD approximates its activated ATP-bound state, and Chk1 does not appear to require activation loop phosphorylation before activity. The authors determined that the regulation of Chk1 may be controlled by its COOH-terminal region; the kinase activity of Chk1KD was 20 times that of full-length Chk1, and autophosphorylation of full-length Chk1 did not inherently affect its kinase activity. The authors speculate on the role of the COOH-terminus in autoinhibition. The crystal structure of the linker region between the kinase domain and the COOH-terminal region indicates that, ...
Se conoce como acto locucionario al acto de decir algo. En este tipo de acto, se puede distinguir tres elemento: el acto fonético, el acto fático y el acto rético. Ejemplo: Acto: Pedir. Vicodin trouble urinating Profesora, no pude terminar el trabajo, ¿Lo puedo entregar la próxima clase? - Acto: Conceder. Ejemplo: Sí. Swim apologizes if this comes to no use for swiy, however, if You is worried that difficulty urinating is uncommon, I want to stress that its literally the most common side effect of opiates.. (in swims opinion) so dont worry. She hopes this reply has been a help to swiy, and she apologizes for the length- but she. does anyone know why this happens? the first time it happened to me i was on oxycontin and it took me like 20 minutes to be able to pee! now i am on vicodin because of some dental work i need done next week - and im having the same problem! what gives? (sorry if this grosses anyone out, but i have to Kidney pain after opiate detox.. ...
TY - JOUR. T1 - The regulation of ATPase-ATPase interactions in sarcoplasmic reticulum membrane. I. The effects of Ca2+, ATP, and inorganic phosphate.. AU - Dux, L.. AU - Martonosi, A.. PY - 1983/10/10. Y1 - 1983/10/10. N2 - Two-dimensional crystalline arrays of Ca2+-ATPase molecules develop after treatment of sarcoplasmic reticulum vesicles with Na3VO4 in calcium-free medium (Dux, L., and Martonosi, A. (1983) J. Biol. Chem. 258, 2599-2603). The formation of Ca2+-ATPase crystals is inhibited by Ca2+ (2 microM), or ATP (5 mM), but not by ADP, 5-adenylylimidodiphosphate, or adenylylmethylenediphosphonate. ATPase crystals did not form at 37 degrees C and exposure of preformed crystals to 37 degrees C for 1 h caused the disappearance of crystal lattice. Inorganic orthophosphate (1 mM at pH 6.0) promoted the formation of a distinct crystal form of Ca2+-ATPase, which was different from that produced by Na3VO4. These observations indicate that Ca2+, ATP, inorganic phosphate, pH, and temperature ...
In cultured intact LLC-PK1 renal epithelial cells, a nonhydrolyzable ATP analogue, ATP gamma S, inhibits AVP-stimulated cAMP formation. In LLC-PK1 membranes, several ATP analogues inhibit basal, GTP-, forskolin-, and AVP-stimulated adenylate cyclase activity in a dose-dependent manner. The rank order potency of inhibition by ATP analogues suggests that a P2y type of ATP receptor is involved in this inhibition. The compound ATP gamma S inhibits agonist-stimulated adenylate cyclase activity in solubilized and in isobutylmethylxanthine (IBMX) and quinacrine pretreated membranes, suggesting that ATP gamma S inhibition occurs independent of AVP and A1 adenosine receptors and of phospholipase A2 activity. The ATP gamma S inhibition of AVP-stimulated adenylate cyclase activity is not affected by pertussis toxin but is attenuated by GDP beta S, suggesting a possible role for a pertussis toxin insensitive G protein in the inhibition. Exposure of intact LLC-PK cells to ATP gamma S results in a significant ...
Synchrotron SAXS data from solutions of Chd1-12N12, chromatin remodeler--nucleosome complex, in 10 mM Tris, 100 mM NaCl, 2 mM MgCl2, 0.1 mM EDTA, 1 mM DTT, 60% (w/v) sucrose, 0.5 mM AMP-PNP, pH 7.8, were collected on the G1 beam line at the Cornell High Energy Synchrotron Source (Ithaca, NY, USA) using a Pilatus Pilatus 200K detector at a sample-detector distance of 2.1 m and at a wavelength of λ = 0.1109 nm (I(s) vs s, where s = 4πsinθ/λ and 2θ is the scattering angle). One solute concentration of 1.88 mg/ml was measured at 25°C. 40 successive 10 second frames were collected. The data were normalized to the intensity of the transmitted beam and radially averaged; the scattering of the solvent-blank was subtracted to produce the scattering profile displayed in this entry. 12N12 nucleosomes in the presence of the chromatin remodeler Chd1 in 60% sucrose and AMP-PNP. The complex formed contains two Chd1 proteins bound to each nucleosome. Due to contrast matching between the solvent and ...
OMEXXEL được phân phối bởi RELI USA, là một công ty chuyên cung cấp có định hướng các loại sản phẩm về dinh dưỡng và mỹ phẩm được nhập khẩu từ Hoa Kỳ do Công ty ExxelUSA sản xuất
11.Mi Cadaver.. Tribulacion Prod & Sylphorium Rec present a brutal cassette with 9 tecnical tracks under the fury a grotesque voice and emanations of dross, are 40 minutes of intense and sick Death metal.....simply brutal !!!. ...
Kinesin 5B兔多克隆抗体(ab5629)可与小鼠, 大鼠, 人样本反应并经WB, IP, ICC/IF实验严格验证,被5篇文献引用并得到2个独立的用户反馈。
Evidence has been presented for the existence in rat liver of P2-purinoceptors which are involved in the control of glycogenolysis. Isolated rat hepatocytes and purified liver plasma membranes have been used to study the binding of the ATP analogue adenosine 5′-[alpha- [35S]thio]triphosphate (ATP alpha [35S]) to these postulated P2-purinoceptors. The nucleotide analogue behaves as a full agonist for the activation of glycogen phosphorylase in isolated hepatocytes, 0.3 microM being required for half-maximal activation. Specific binding of ATP alpha [35S] to hepatocytes and plasma membranes occurs within 1 min and is essentially reversible. The analysis of the dose-dependency at equilibrium indicates the presence of binding sites with Kd of 0.23 microM with hepatocytes and Kd of 0.11 microM with plasma membranes. The relative affinities of 10 nucleotide analogues were deduced from competition experiments for ATP alpha [35S] binding to hepatocytes, and these correlated highly with their ...
TY - JOUR. T1 - The influence of guanyl-5′-yl imidodiphosphate and sodium chloride on the binding of the muscarinic agonist, [3H] cis methyldioxolane. AU - Ehlert, Frederick J.. AU - Yamamura, Henry I.. AU - Triggle, David J.. AU - Roeske, William R.. N1 - Funding Information: The authors whish to acknowledge the excellent technical assistance of Reiko Yamada and Andy Chen and Secretarial assistance of Cathy Thomas. Portions of this work were supported by United States Public Health Service Grants MH-27257, MH-30626, HL-21486, and Program Project Grant HL-20984. H.I.Y. is a recipient of a USPHS RSDA, type II (MH-00095), from the National Institute of Mental Health.. PY - 1980/2/8. Y1 - 1980/2/8. UR - http://www.scopus.com/inward/record.url?scp=0018859075&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0018859075&partnerID=8YFLogxK. U2 - 10.1016/0014-2999(80)90135-1. DO - 10.1016/0014-2999(80)90135-1. M3 - Article. C2 - 7363942. AN - SCOPUS:0018859075. VL - 61. SP - ...
Mua sản phẩm Sen Cây Viglacera Platinum P.57.350 Nóng Lạnh giá rẻ tại Khalinguyen. Giao hàng nhanh. Hàng chính hãng nhập khẩu từ các thương hiệu nổi tiếng trên thị trường thiết bị vệ sinh và nhà bếp
Bao Hai Duong, Doc Bao,Đọc Báo,tin tuc,tin mới, thời sự - sự kiện, vấn đề hôm nay, hoạt động kiểm toán, kinh tế xã hội,hội nhập và phát triển,văn hóa, thể thao, giải trí...
Doc Bao,Đọc Báo,tin tuc,tin mới, thời sự - sự kiện, vấn đề hôm nay, hoạt động kiểm toán, kinh tế xã hội,hội nhập và phát triển,văn hóa, thể thao, giải trí...
TY - JOUR. T1 - Identification of a DNA supercoiling activity in Saccharomyces cerevisiae. AU - Koo, Hyeon Sook. AU - Lau, Kawai. AU - Wu, Hai Young. AU - Liu, Leroy-Fong. PY - 1992/10/11. Y1 - 1992/10/11. N2 - A relaxed plasmid DNA is shown to become positively supercoiled in cell extracts from top1 strains of Saccharomyces cerevisiae. This positive supercoiling activity is dependent on the presence of bacterial DNA topoisomerase I and ATP (or dATP), and the positive supercoils generated in this reaction are not constrained by protein(s). Non-hydrolyzable ATP analogs cannot substitute for ATP in this supercoiling reaction, and the supercoiling activity is not due to RNA synthesis. The presence of an ARS sequence in the DNA does not alter the activity. Furthermore, this activity is equally active against UV irradiated or intact DNA. Extracts prepared from rad50 and rad52 mutant cells exhibited the same activity. Partial purification of this activity suggests that a protein factor with a native ...
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Magnesium atom in PDB 1un9: Crystal Structure of the Dihydroxyacetone Kinase From C. Freundii in Complex With Amp-Pnp and MG2+
ACK1 is a multidomain non-receptor tyrosine kinase that is an effector of the Cdc42 GTPase. Members of the ACK family have a unique domain ordering and are the only tyrosine kinases known to interact with Cdc42. In contrast with many protein kinases, ACK1 has only a modest increase in activity upon phosphorylation. We have solved the crystal structures of the human ACK1 kinase domain in both the unphosphorylated and phosphorylated states. Comparison of these structures reveals that ACK1 adopts an activated conformation independent of phosphorylation. Furthermore, the unphosphorylated activation loop is structured, and its conformation resembles that seen in activated tyrosine kinases. In addition to the apo structure, complexes are also presented with a non-hydrolyzable nucleotide analog (adenosine 5-(beta,gamma-methylenetriphosphate)) and with the natural product debromohymenialdisine, a general inhibitor of many protein kinases. Analysis of these structures reveals a typical kinase fold, a ...
Với dịch vụ ship hàng từ mỹ chúng tôi sẽ giúp bạn dễ dàng thực hiện việc vận chuyển hàng từ mỹ về việt nam. Nếu bạn có thắc mắc như amazon có ship về việt nam không, amazon là gì, ebay là gì? Hãy cứ liên hệ hoặc truy cập vào website của chúng tôi để được giải đáp. Ngoài ra chúng tôi còn nhận nhập hàng từ hàn quốc, gửi hàng đi mỹ, hàng nhập khẩu từ đức, gửi hàng đi anh, chuyển hàng đi pháp, gửi hàng đi đức, hàng nhập khẩu từ pháp, ship hàng úc, ship hàng nga, gửi hàng từ thái lan về việt nam ,... Và vô số dịch vụ vận chuyển đang chờ đợi bạn. Hãy liên hệ chúng tôi khi bạn cần nhé.. ReplyDelete ...
Kinesin motor protein, molecular model. Kinesin motor proteins transport vesicles containing intracellular cargo around the cell along microtubules. - Stock Image F009/6428
500 years ago, Nguyen Trai praised the beauty of Ha Long Bay in his verse Lộ nhập Vân Đồn, in which he called it rock wonder in the sky. Even though Ha Long Bay has an area of around 1,553 km2, no one is allowed to make there home on land. Instead people live on floating houses, sometimes as part of a floating village and use boats for transport.. Vietnamfloating villageHa Long BayPhotito travelphotitotraveltravel photographydocumentary photographyspencerphotographyculturewww.photito.com ...
Mua sản phẩm Vòi Lavabo Viglacera Platinum P.52.351 Nóng Lạnh Thân Cao giá rẻ tại Khalinguyen. Giao hàng nhanh. Hàng chính hãng nhập khẩu từ các thương hiệu nổi tiếng trên thị trường thiết bị vệ sinh và nhà bếp
mài sản xuất nhà máy trong chúng ta. Đột nhập một trong những nhà máy sản xuất lõi bút chì cuối . Đột nhập một trong những nhà máy sản xuất lõi bút chì cuối cùng của Mỹ, tất cả thực sự rất tuyệt vời Nhiếp ảnh gia Christopher Payne đã chụp một bộ ảnh thể hiện một thế giới đầy sắc màu và tinh .... Giá Việt Nam năm 2021 ...
A potent, synthetic cannabinoid was radiolabeled and used to characterize and precisely localize cannabinoid receptors in slide- mounted sections of rat brain and pituitary. Assay conditions for 3H- CP55,940 binding in Tris-HCl buffer with 5% BSA were optimized, association and dissociation rate constants determined, and the equilibrium dissociation constant (Kd) calculated (21 nM by liquid scintillation counting, 5.2 nM by quantitative autoradiography). The results of competition studies, using several synthetic cannabinoids, add to prior data showing enantioselectivity of binding and correlation of in vitro potencies with potencies in biological assays of cannabinoid actions. Inhibition of binding by guanine nucleotides was selective and profound: Nonhydrolyzable analogs of GTP and GDP inhibited binding by greater than 90%, and GMP and the nonhydrolyzable ATP analog showed no inhibition. Autoradiography showed great heterogeneity of binding in patterns of labeling that closely conform to ...
Dermatan 4-sulfotransferase (EC 2.8.2.35, dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase, dermatan-4-sulfotransferase-1, dermatan-4-sulfotransferase 1, D4ST-1, dermatan N-acetylgalactosamine 4-O-sulfotransferase, CHST14 protein, CHST14) is an enzyme with systematic name 3-phospho-5-adenylyl sulfate:(dermatan)-N-acetyl-D-galactosamine 4-sulfotransferase. This enzyme catalyses the following chemical reaction 3-phospho-5-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine ⇌ {\displaystyle \rightleftharpoons } adenosine 3,5-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. Evers, M.R.; Xia, G.; Kang, H.G.; Schachner, M.; Baenziger, J.U. (2001). Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase. J. Biol. Chem. 276: 36344-36353. doi:10.1074/jbc.M105848200. PMID 11470797. Mikami, T.; Mizumoto, S.; Kago, N.; Kitagawa, ...
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk (By similarity).
Công tố viên toà án Seoul phủ nhận việc một tờ báo đưa tin họ đã cố tình lấp liếm việc Park Bom vận chuyển thuốc kích thích bất hợp pháp từ Hoa Kỳ vào Nam Hàn cách đây 4 năm. Sáng thứ Hai, Segye Ilbo đã đưa tin hải quan Nam Hàn bắt gặp Park…
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鈉鉀泵可以將細胞外相對細胞内較低濃度的鉀離子送進細胞,並將細胞内相對細胞外較低濃度的鈉離子送出細胞。經由以具放射性的鈉、鉀離子標定,可以發現鈉、鉀離子都會經過這個通道,鈉、鉀離子的濃度在細胞膜兩側也都是相互依賴的,所以顯示了鈉、鉀離子都可以經過這個載體運輸。目前已知鈉鉀泵需消耗ATP,並可以將三個鈉離子送出細胞,同時將兩個鉀離子送進細胞。 鈉鉀泵在1950年被丹麥的科學家延斯·斯科(Jens Skou)發現,它代表了我們對離子進出細胞的認識的一個重要的里程碑。它也在細胞刺激上有著重要的意義,像神經細胞的衝動,就是用鈉鉀泵幫助維持細胞電位使神經衝動得以傳輸。 ...
鈉鉀泵可以將細胞外相對細胞内較低濃度的鉀離子送進細胞,並將細胞内相對細胞外較低濃度的鈉離子送出細胞。經由以具放射性的鈉、鉀離子標定,可以發現鈉、鉀離子都會經過這個通道,鈉、鉀離子的濃度在細胞膜兩側也都是相互依賴的,所以顯示了鈉、鉀離子都可以經過這個載體運輸。目前已知鈉鉀泵需消耗ATP,並可以將三個鈉離子送出細胞,同時將兩個鉀離子送進細胞。 鈉鉀泵在1950年被丹麥的科學家延斯·斯科(Jens Skou)發現,它代表了我們對離子進出細胞的認識的一個重要的里程碑。它也在細胞刺激上有著重要的意義,像神經細胞的衝動,就是用鈉鉀泵幫助維持細胞電位使神經衝動得以傳輸。 ...
அடினோசின் முப்பொசுபேற்று அல்லது அடினோசின் முப்பாசுப்பேட்டு (Adenosine triphosphate (ATP)) என்பது அனைத்து உயிரினங்களின் கலங்களிலும் பயன்படுத்தப்படும் ஒரு முக்கியமான துணை நொதியமாகும். இது உயிரினங்களில் சக்திக்கான அளவீடாக உள்ளது. கலத்துக்கிடையில் அனுசேபத்துக்காக சக்தியை இடம் மாற்றும் முக்கியமான மூலக்கூறாக அடினோசின் முப்பொசுபேற்று விளங்குகின்றது. ஒளித்தொகுப்பு, காற்றுள்ள சுவாசம் ...
The structure of MsbA-AMP-PNP (5'-adenylyl-β-γ-imidodiphosphate), obtained from S. typhimurium, is similar to Sav1866. The NBDs ... adenylyl-β-γ-imidodiphosphate (AMP-PNP), showed that ATP binding, in the absence of hydrolysis, is sufficient to reduce ...
In a closed state, the two domains of eIF4AIII form composite binding sites for the 5'-adenylyl-β,γ-imidodiphosphate (ADPNP) ...
... adenylyl-imidodiphosphate, a substrate analog of ATP, and 3-acetylpyridine adenine dinucleotide, a substrate analog of NADH. As ...
... adenylyl imidodiphosphate MeSH D13.695.667.138.236.250 - ethenoadenosine triphosphate MeSH D13.695.667.138.382 - coenzyme a ... adenylyl imidodiphosphate MeSH D13.695.827.068.236.250 - ethenoadenosine triphosphate MeSH D13.695.827.068.382 - coenzyme a ... guanylyl imidodiphosphate MeSH D13.695.667.454.525 - 5'-guanylic acid MeSH D13.695.667.454.700 - rna caps MeSH D13.695.667.454. ... guanylyl imidodiphosphate MeSH D13.695.827.426.525 - 5'-guanylic acid MeSH D13.695.827.426.700 - rna caps MeSH D13.695.827.426. ...
When the analog adenylyl-imidodiphosphate was substituted for ATP, nonhomologous pairs of circular DNA molecules became linked. ... Adenosine Triphosphate, Adenylyl Imidodiphosphate, Basidiomycota, DNA Topoisomerases, Type I, DNA, Circular, ...
Adenylyl imidodiphosphate (AMPPNP), a nonhydrolyzable analogue of ATP. 3 shows an example consisting of four processes. ...
Adenosine TriphosphatasesAdenosine TriphosphateAdenylyl ImidodiphosphateDEAD-box RNA HelicasesEscherichia coliEscherichia coli ...
Adenylyl imidodiphosphate (AMP‐PNP), a non‐hydrolyzable analogue of ATP produces a stable intermediate in the motility cycle of ...
Adenylyl Imidodiphosphate. Transcription Factors. Pubs id:. pubs:246326. UUID:. uuid:ccea1b79-511e-4189-97bd-70abc526c445 ...
Guanylyl Imidodiphosphate Medicine & Life Sciences 100% * Guanine Nucleotides Medicine & Life Sciences 84% ... Adenylyl Cyclases Medicine & Life Sciences 69% * Guanine Chemical Compounds 66% * Nucleotide Chemical Compounds 55% ...
Adenylyl Imidodiphosphate Medicine & Life Sciences 76% * Plasmids Medicine & Life Sciences 60% * Nucleotides Medicine & Life ...
15N and 17O NMR Studies of the Proton Binding Sites in Imidodiphosphate, Tetraethyl Imidodiphosphate, and Adenylyl ... Imidodiphosphate. Reynolds, M. A., Gerlt, J. A., Demou, P. C., Oppenheimer, N. J. & Kenyon, G. L., Oct 1983, In: Journal of the ...
Both Gln and Glu mutant proteins can form a clamp complex in the presence of 5'-adenylyl-beta,gamma-imidodiphosphate, albeit ...
... γ-imidodiphosphate, GDP, and GMP. Guanosine 5′-O-(2-thiodiphosphate), an analog of GDP which blocks guanine nucleotide- and ... Adenylyl Cyclases Medicine & Life Sciences 74% * Peptides Medicine & Life Sciences 46% * Guanine Chemical Compounds 40% ... γ-imidodiphosphate, GDP, and GMP. Guanosine 5′-O-(2-thiodiphosphate), an analog of GDP which blocks guanine nucleotide- and ... γ-imidodiphosphate, GDP, and GMP. Guanosine 5′-O-(2-thiodiphosphate), an analog of GDP which blocks guanine nucleotide- and ...
ADENYLYL IMIDODIPHOSPHATE] 93. ԱԴԻՊԻՆԱՅԻՆ ԹԹՈՒՆԵՐ [ADIPIC ACIDS] 44. ԱԴԵՆԻԼԻԼԻՄԻԴՈԴԻՖՈՍՖԱՏ [ADENYLYL IMIDODIPHOSPHATE] 94. ...
We recently reported that a nonhydrolyzable form of ATP, adenylyl imidodiphosphate (AMPPNP), stabilizes but is not required for ... We recently reported that a nonhydrolyzable form of ATP, adenylyl imidodiphosphate (AMPPNP), stabilizes but is not required for ... We recently reported that a nonhydrolyzable form of ATP, adenylyl imidodiphosphate (AMPPNP), stabilizes but is not required for ... We recently reported that a nonhydrolyzable form of ATP, adenylyl imidodiphosphate (AMPPNP), stabilizes but is not required for ...
15N and 17O NMR Studies of the Proton Binding Sites in Imidodiphosphate, Tetraethyl Imidodiphosphate, and Adenylyl ... Imidodiphosphate. Reynolds, M. A., Gerlt, J. A., Demou, P. C., Oppenheimer, N. J. & Kenyon, G. L., Oct 1983, In: Journal of the ...
The Kd of Raf-1 for the modified H-Ras, 3.5 nM, was significantly lower than that for Ras2, 24 nM, whereas adenylyl cyclase ... Its dissociation constant with p21ras.guanyl-5'-yl imidodiphosphate was found to be 18 nM, with a slight preference for H-ras ... We found that in vitro activation of adenylyl cyclase by yeast Ras2 and human H-Ras proteins is subject to competitive ... In addition, V45E mutation was found to impair the ability of Ras to activate both Raf-1 and adenylyl cyclase without ...
17.Sakharov, P. A., Sokolov, A. S., and Agalarov, S. C. (2015) Nonhydrolyzable ATP analog 5′-adenylyl-imidodiphosphate (AMP-PNP ...
Effects of adenylyl imidodiphosphate, a nonhydrolyzable adenosine triphosphate analog, on reactivated and rigor wave sea urchin ...
"Adenylyl Imidodiphosphate" by people in this website by year, and whether "Adenylyl Imidodiphosphate" was a major or minor ... "Adenylyl Imidodiphosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Adenylyl Imidodiphosphate" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Adenylyl Imidodiphosphate". ...
15N and 17O NMR Studies of the Proton Binding Sites in Imidodiphosphate, Tetraethyl Imidodiphosphate, and Adenylyl ... Imidodiphosphate. Reynolds, M. A., Gerlt, J. A., Demou, P. C., Oppenheimer, N. J. & Kenyon, G. L., Oct 1983, In: Journal of the ...
... catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and ...
Abbreviations used in this paper: AMPPNP, 5′-adenylyl-imidodiphosphate; KHC, kinesin heavy chain. ... Abbreviations used in this paper: AMPPNP, 5′-adenylyl-imidodiphosphate; KHC, kinesin heavy chain. ... adenylyl-imidodiphosphate (AMPPNP). However, nucleotide-free kinesin was not included in the KIF1A study. Furthermore, a second ... adenylyl-methylenediphosphate; Kikkawa et al., 2001) or AMPPNP (Nitta et al., 2004). On the other hand, the more recent ...
... adenylyl imidodiphosphate (AMP-PNP)-induced microtubule affinity purification of the plus-end vesicles. In the presence of ...
La bièrra sembla èsser apareguda ambé lei culturas de cerealas en Mesopotamia Anciana. Pasmens, en causa de la manca de donadas, la data precisa es desconeguda. D'un biais generau, es situada vèrs 6 000 avC car lei tecnologias dau periòde (mestritge de la produccion d'òrdi e de blat[1], terralhas capablas de protegir una bevenda alcoolizada...) permetián alora son existéncia[2]. La premiera traça clarament atestada data dau milleni IV avC e foguèt descubèrta en Sumèr. Dicha « sikaru », fasiá partida dau manjar de la vida vidante e sa fabricacion èra protegida per la divessa Ninkasi[3]. Èra producha a partir de fogassas d'òrdi ò d'espèuta trempadas dins l'aiga per entraïnar la fermentacion. D'autreis ingredients i èran de còps aponduts (mèu, espècias...) per ne melhorar lo gost. A partir de Mesopotamia, la bièrra se difusèt vèrs lei regions vesinas[4]. Pasmens, es tanben possible que dins certaneis endrechs, de descubèrtas independentas aguèron luòc. Que mecanisme ...
Bel Air (or Bel-Air) is a neighborhood in the Los Angeles Westside, in the foothills of the Santa Monica Mountains. It was founded in 1923. It is a lightly populated residential district. The people are older, well-educated, and have high incomes. ...
The follaein 2 pages is in this categerie, oot o 2 awthegither. ...
Schooda (dt.: Schotter, engl.: crushed stone (kinstle), gravel (natiale)) san kloane Breckal bzw. Keandln vo Stoana und Fejsn, wo natiale oda kinstle entstondn san und gressa wia 2 mm san. Wonns kloana san, is's a Sond. A Schooda wo natiale entstondn is, nennd ma aa Kisl. A Schooda wo kinstle brocha is, nennd ma Splitt. ...
"Adenylyl Imidodiphosphate" by people in this website by year, and whether "Adenylyl Imidodiphosphate" was a major or minor ... "Adenylyl Imidodiphosphate" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Adenylyl Imidodiphosphate" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Adenylyl Imidodiphosphate". ...
We recently reported that a nonhydrolyzable form of ATP, adenylyl imidodiphosphate (AMPPNP), stabilizes but is not required for ... We recently reported that a nonhydrolyzable form of ATP, adenylyl imidodiphosphate (AMPPNP), stabilizes but is not required for ... We recently reported that a nonhydrolyzable form of ATP, adenylyl imidodiphosphate (AMPPNP), stabilizes but is not required for ... We recently reported that a nonhydrolyzable form of ATP, adenylyl imidodiphosphate (AMPPNP), stabilizes but is not required for ...
15N and 17O NMR Studies of the Proton Binding Sites in Imidodiphosphate, Tetraethyl Imidodiphosphate, and Adenylyl ... Imidodiphosphate. Reynolds, M. A., Gerlt, J. A., Demou, P. C., Oppenheimer, N. J. & Kenyon, G. L., Oct 1983, In: Journal of the ...
Abbreviations used in this paper: AMPPNP, 5′-adenylyl-imidodiphosphate; KHC, kinesin heavy chain. ... Abbreviations used in this paper: AMPPNP, 5′-adenylyl-imidodiphosphate; KHC, kinesin heavy chain. ... adenylyl-imidodiphosphate (AMPPNP). However, nucleotide-free kinesin was not included in the KIF1A study. Furthermore, a second ... adenylyl-methylenediphosphate; Kikkawa et al., 2001) or AMPPNP (Nitta et al., 2004). On the other hand, the more recent ...
Adenylyl Imidodiphosphate D3.438.759.646.138.236.50 D3.633.100.759.646.138.236.50 Adhesiveness G2.842.850.139 G2.860.139 ... Guanylyl Imidodiphosphate D3.438.759.646.454.504.400 D3.633.100.759.646.454.504.400 Guernsey Z1.639.280.161.500 Gymnastics ...
Adenyl Imidodiphosphate Adenylimidodiphosphate Adenylylimidodiphosphate Imidodiphosphate, Adenyl Imidodiphosphate, Adenylyl ... Adenylylimidodiphosphate. Imidodiphosphate, Adenyl. Imidodiphosphate, Adenylyl. Mg 5 Adenylylimidodiphosphate. Mg AMP PNP. Mg ... Adenylyl Imidodiphosphate - Preferred Concept UI. M0000416. Scope note. 5-Adenylic acid, monoanhydride with imidodiphosphoric ... Adenylyl Imidodiphosphate Entry term(s). AMP-PNP AMPPNP ATP(beta,gamma-NH) Adenosine 5-(beta,gamma-Imino)triphosphate ...
Both Gln and Glu mutant proteins can form a clamp complex in the presence of 5-adenylyl-beta,gamma-imidodiphosphate, albeit ...
... catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and ...
... adenylyl-imidodiphosphate) binding to wild-type myosin subfragment-1 enhanced tryptophan fluorescence by approximately 15% or ...
ADENYLYL IMIDODIPHOSPHATE] 93. ԱԴԻՊԻՆԱՅԻՆ ԹԹՈՒՆԵՐ [ADIPIC ACIDS] 44. ԱԴԵՆԻԼԻԼԻՄԻԴՈԴԻՖՈՍՖԱՏ [ADENYLYL IMIDODIPHOSPHATE] 94. ...
... adenylyl imidodiphosphate (AMP-PNP), and the proteins in a yeast cell lysate. The new methodology enabled the interrogation of ... adenylyl imidodiphosphate (AMP-PNP). The well-known tight-binding interaction between CsA and cyclophilin A was successfully ...
Adenylyl Imidodiphosphate D3.438.759.646.138.236.50 D3.633.100.759.646.138.236.50 Adhesiveness G2.842.850.139 G2.860.139 ... Guanylyl Imidodiphosphate D3.438.759.646.454.504.400 D3.633.100.759.646.454.504.400 Guernsey Z1.639.280.161.500 Gymnastics ...
Adenylyl Imidodiphosphate D3.438.759.646.138.236.50 D3.633.100.759.646.138.236.50 Adhesiveness G2.842.850.139 G2.860.139 ... Guanylyl Imidodiphosphate D3.438.759.646.454.504.400 D3.633.100.759.646.454.504.400 Guernsey Z1.639.280.161.500 Gymnastics ...
Adenylyl Imidodiphosphate D3.438.759.646.138.236.50 D3.633.100.759.646.138.236.50 Adhesiveness G2.842.850.139 G2.860.139 ... Guanylyl Imidodiphosphate D3.438.759.646.454.504.400 D3.633.100.759.646.454.504.400 Guernsey Z1.639.280.161.500 Gymnastics ...
Adenylyl Imidodiphosphate D3.438.759.646.138.236.50 D3.633.100.759.646.138.236.50 Adhesiveness G2.842.850.139 G2.860.139 ... Guanylyl Imidodiphosphate D3.438.759.646.454.504.400 D3.633.100.759.646.454.504.400 Guernsey Z1.639.280.161.500 Gymnastics ...
17.Sakharov, P. A., Sokolov, A. S., and Agalarov, S. C. (2015) Nonhydrolyzable ATP analog 5′-adenylyl-imidodiphosphate (AMP-PNP ...
... γ-imidodiphosphate, GDP, and GMP. Guanosine 5′-O-(2-thiodiphosphate), an analog of GDP which blocks guanine nucleotide- and ... Adenylyl Cyclases Medicine & Life Sciences 74% * Peptides Medicine & Life Sciences 46% * Guanine Chemical Compounds 40% ... γ-imidodiphosphate, GDP, and GMP. Guanosine 5′-O-(2-thiodiphosphate), an analog of GDP which blocks guanine nucleotide- and ... γ-imidodiphosphate, GDP, and GMP. Guanosine 5′-O-(2-thiodiphosphate), an analog of GDP which blocks guanine nucleotide- and ...
Adenylyl Imidodiphosphate. 5′-Adenylic acid, monoanhydride with imidodiphosphoric acid. An analog of ATP, in which the oxygen ...
MeSH Terms: Adenosine Diphosphate/metabolism; Adenosine Triphosphate/metabolism; Adenylyl Imidodiphosphate/metabolism; Animals ...
Adenylyl Imidodiphosphate / chemistry Actions. * Search in PubMed * Search in MeSH * Add to Search ...
Adenylyl Imidodiphosphate / metabolism* Actions. * Search in PubMed * Search in MeSH * Add to Search ...
Cryo-EM samples were prepared by mixing ATM with the non-hydrolyzable ATP analog adenylyl-imidodiphosphate (AMP-PNP) and MgCl2 ...
APPNHP is an acronym for adenylyl imidodiphosphate. approx is an abbreviation of approximate. approx is an abbreviation of ...
Adenylyl Imidodiphosphate / metabolism Actions. * Search in PubMed * Search in MeSH * Add to Search ...
Adenyl Imidodiphosphate Adenylimidodiphosphate Adenylylimidodiphosphate Mg AMP-PNP Mg-5-Adenylylimidodiphosphate beta,gamma- ... Adenylyl Imidodiphosphate Preferred Term Term UI T000835. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1976). ... Adenylyl Imidodiphosphate Preferred Concept UI. M0000416. Registry Number. 25612-73-1. Scope Note. 5-Adenylic acid, ... Mg-5-Adenylylimidodiphosphate Narrower Concept UI. M0000417. Registry Number. 0. Terms. Mg-5-Adenylylimidodiphosphate ...
Adenyl Imidodiphosphate Adenylimidodiphosphate Adenylylimidodiphosphate Mg AMP-PNP Mg-5-Adenylylimidodiphosphate beta,gamma- ... Adenylyl Imidodiphosphate Preferred Term Term UI T000835. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1976). ... Adenylyl Imidodiphosphate Preferred Concept UI. M0000416. Registry Number. 25612-73-1. Scope Note. 5-Adenylic acid, ... Mg-5-Adenylylimidodiphosphate Narrower Concept UI. M0000417. Registry Number. 0. Terms. Mg-5-Adenylylimidodiphosphate ...
Omitting ATP or substituting it with the nonhydrolyzable adenylyl-imidodiphosphate analogue resulted in an ∼50% reduction in ... with 2 mM adenylyl-imidodiphosphate (+AMP-PNP), with 1 μM of recombinant RN-tre (+RN-tre), with 1 μM Rab-GDI (+GDI), with 1 μM ... with 2 mM adenylyl-imidodiphosphate (+AMP-PNP), with 1 μM of recombinant RN-tre (+RN-tre), with 1 μM Rab-GDI (+GDI), with 1 μM ...
15N and 17O NMR Studies of the Proton Binding Sites in Imidodiphosphate, Tetraethyl Imidodiphosphate, and Adenylyl ... Imidodiphosphate. Reynolds, M. A., Gerlt, J. A., Demou, P. C., Oppenheimer, N. J. & Kenyon, G. L., Oct 1983, In: Journal of the ...
... adenylyl-imidodiphosphate; PNP, di- phosphoimide; ADP-NH;, 5-adenylyl-phosphoamide; cyclic AMP, cyclic-3,5-AMP. 1877 1878 ... adenylyl imidodiphosphate labeled with **P at the a posi- tion (AMP-PNP-a-"*P), an analogue of ATP containing nitro- gen ...
15N and 17O NMR Studies of the Proton Binding Sites in Imidodiphosphate, Tetraethyl Imidodiphosphate, and Adenylyl ... Imidodiphosphate. Reynolds, M. A., Gerlt, J. A., Demou, P. C., Oppenheimer, N. J. & Kenyon, G. L., Oct 1983, In: Journal of the ...
... opossum hyperextension statistics pertechnetate variecolor mannuronate rhenium serotype street hypochlorous zoarces adenylyl ... rheumatology depriest interparietal nitroflavone yankauer rubber pleated manipur juniperus phenylacetylene imidodiphosphate ... monocotyle octabromodiphenyl thiazepine furnaces linderae unlock hiragana deluxe allexivirus adenylylimidodiphosphate ...
Adenylate Kinase N0000168017 Adenylosuccinate Lyase N0000167766 Adenylosuccinate Synthase N0000170831 Adenylyl Imidodiphosphate ... Cyclase-Activating Proteins N0000168258 Guanylate Kinase N0000166459 Guanylthiourea N0000170847 Guanylyl Imidodiphosphate ...
MeSH Terms: Adenylyl Imidodiphosphate, Amsacrine, Animals, DNA, DNA Topoisomerases, Type II, Drosophila melanogaster, Etoposide ...
Adenylyl Imidodiphosphate D3.438.759.646.138.236.50 D3.633.100.759.646.138.236.50 Adhesiveness G2.842.850.139 G2.860.139 ... Guanylyl Imidodiphosphate D3.438.759.646.454.504.400 D3.633.100.759.646.454.504.400 Guernsey Z1.639.280.161.500 Gymnastics ...
D3.438.759.590.138.25 Adenylyl Imidodiphosphate D3.438.759.646.138.236.50 Adiposis Dolorosa C17.800.849.77 C17.800.463.249 ... D3.438.759.646.454.504 Guanylyl Imidodiphosphate D3.438.759.646.454.504.400 Guided Tissue Regeneration, Periodontal E6.645.410 ...
... adenylyl imidodiphosphate adenylyl-imidodiphosphate adenylyl-imido diphosphate adenylyl-imido-diphosphate adenylylimido ... diphosphate adenylylimido-diphosphate adenylyl phosphosulfate reductase adenylyl phosphosulphate reductase adenylyls ... cyclase beta-adrenergic receptor-adenylate cyclase beta adrenergic receptor adenylyl cyclase beta-adrenergic receptor-adenylyl ... adenyltransferases adenylyl adenylylate adenylylated adenylylates adenylylating adenylylation adenylylcyclase adenylyl cyclase ...
Adenylyl Cyclase Inhibitors Adenylyl Cyclases Adenylyl Imidodiphosphate Adherens Junctions Adhesins, Bacterial Adhesins, ...
  • We recently reported that a nonhydrolyzable form of ATP, adenylyl imidodiphosphate (AMPPNP), stabilizes but is not required for the activation of NPR-A and NPR-B in membranes from highly overexpressing cells. (umn.edu)
  • A pair of newly published cryo-EM structures at a resolution of ∼1 nm of the KIF1A kinesin ( Kikkawa and Hirokawa, 2006 ) are consistent with the relay helix theory for two of the three principal nucleotide states, finding the switch II helix ADP-like in ADP-bound, microtubule-bound kinesin and ATP-like in microtubule-bound kinesin with the nonhydrolyzable ATP analogue 5′-adenylyl-imidodiphosphate (AMPPNP). (rupress.org)
  • Adenylyl Imidodiphosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • The labeled peptide and guanine nucleotide regulatory protein activity were coeluted from the affinity matrix by guanylyl-β,γ-imidodiphosphate, GDP, and GMP. (elsevier.com)
  • While ATP or AMP-PNP (adenylyl-imidodiphosphate) binding to wild-type myosin subfragment-1 enhanced tryptophan fluorescence by approximately 15% or approximately 8%, respectively, enhancement does not occur in the mutant. (nih.gov)