A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyzes the synthesis of adenylosuccinate from GTP; IMP; and aspartate with the formation of orthophosphate and GDP. EC 6.3.4.4.
An enzyme that, in the course of purine ribonucleotide biosynthesis, catalyzes the conversion of 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole to 5'-phosphoribosyl-4-carboxamide-5-aminoimidazole and the conversion of adenylosuccinic acid to AMP. EC 4.3.2.2.
Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
Camellia sinensis L. (formerly Thea sinensis) is an evergreen Asiatic shrub of the THEACEAE family. The infusion of leaves of this plant is used as Oriental TEA which contains CAFFEINE; THEOPHYLLINE; and epigallocatechin gallate.
A plant genus in the family THEACEAE, order THEALES best known for CAMELLIA SINENSIS which is the source of Oriental TEA.
A plant genus of the family ERICACEAE.
The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.
A species of trematode flukes of the family Opisthorchidae. Many authorities consider this genus belonging to Opisthorchis. It is common in China and other Asiatic countries. Snails and fish are the intermediate hosts.
An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Purines attached to a RIBOSE and a phosphate that can polymerize to form DNA and RNA.
Enzymes that catalyze the transfer of hydroxymethyl or formyl groups. EC 2.1.2.
A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
An enzyme, involved in the early steps of purine nucleotide biosynthesis, that catalyzes the formation of 5-phosphoribosylamine from glutamine and phosphoribosylpyrophosphate. EC 2.4.2.14.
An order of anaerobic, highly specialized methanogens, in the kingdom EURYARCHAEOTA. Its organisms are nonmotile or motile, with cells occurring as coccoid bodies, pseudosarcina, or rods. Families include METHANOMICROBIACEAE, Methanocorpusculaceae, and Methanospirillaceae.
A phylum of acoelomate, bilaterally symmetrical flatworms, without a definite anus. It includes three classes: Cestoda, Turbellaria, and Trematoda.
An enzyme that catalyzes reversibly the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to yield phosphatidylethanolamine (cephalin) and CMP. The enzyme is found in the endoplasmic reticulum. EC 2.7.8.1.
A sub-class of protein tyrosine phosphatases that contain an additional phosphatase activity which cleaves phosphate ester bonds on SERINE or THREONINE residues that are located on the same protein.
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
An actinomycete from which the antibiotics STREPTOMYCIN, grisein, and CANDICIDIN are obtained.
The sequence at the 3' end of messenger RNA that does not code for product. This region contains transcription and translation regulating sequences.
An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.
An order of insect eating MAMMALS including MOLES; SHREWS; HEDGEHOGS and tenrecs.
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.
The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.
The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
A group of inosine ribonucleotides in which the phosphate residues of each inosine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.

Combinatorial interactions regulate cardiac expression of the murine adenylosuccinate synthetase 1 gene. (1/71)

The mammalian heart begins contracting at the linear tube stage during embryogenesis and continuously pumps, nonstop, throughout the entire lifetime of the animal. Therefore, the cardiac energy metabolizing pathways must be properly established and efficiently functioning. While the biochemistry of these pathways is well defined, limited information regarding the regulation of cardiac metabolic genes is available. Previously, we reported that 1.9 kilobase pairs of murine adenylosuccinate synthetase 1 gene (Adss1) 5'-flanking DNA directs high levels of reporter expression to the adult transgenic heart. In this report, we define the 1.9-kilobase pair fragment as a cardiac-specific enhancer that controls correct spatiotemporal expression of a reporter similar to the endogenous Adss1 gene. A 700-base pair fragment within this region activates a heterologous promoter specifically in adult transgenic hearts. Proteins present in a cardiac nuclear extract interact with potential transcription factor binding sites of this region and these cis-acting sites play important regulatory roles in the cardiac expression of this reporter. Finally, we report that several different cardiac transcription factors trans-activate the 1.9HSCAT construct through these sites and that combinations result in enhanced reporter expression. Adss1 appears to be one of the first target genes identified for the bHLH factors Hand1 and Hand2.  (+info)

Effectors of the stringent response target the active site of Escherichia coli adenylosuccinate synthetase. (2/71)

Guanosine 5'-diphosphate 3'-diphosphate (ppGpp), a pleiotropic effector of the stringent response, potently inhibits adenylosuccinate synthetase from Escherichia coli as an allosteric effector and/or as a competitive inhibitor with respect to GTP. Crystals of the synthetase grown in the presence of IMP, hadacidin, NO3-, and Mg2+, then soaked with ppGpp, reveal electron density at the GTP pocket which is consistent with guanosine 5'-diphosphate 2':3'-cyclic monophosphate. Unlike ligand complexes of the synthetase involving IMP and GDP, the coordination of Mg2+ in this complex is octahedral with the side chain of Asp13 in the inner sphere of the cation. The cyclic phosphoryl group interacts directly with the side chain of Lys49 and indirectly through bridging water molecules with the side chains of Asn295 and Arg305. The synthetase either directly facilitates the formation of the cyclic nucleotide or scavenges trace amounts of the cyclic nucleotide from solution. Regardless of its mode of generation, the cyclic nucleotide binds far more tightly to the active site than does ppGpp. Conceivably, synthetase activity in vivo during the stringent response may be sensitive to the relative concentrations of several effectors, which together exercise precise control over the de novo synthesis of AMP.  (+info)

Adenylosuccinate synthase from Saccharomyces cerevisiae: homologous overexpression, purification and characterization of the recombinant protein. (3/71)

Adenylosuccinate synthase (EC 6.3.4.4) catalyses the first committed step in the synthesis of adenosine. We have overexpressed the cloned gene of Saccharomyces cerevisiae (ADE12) in S. cerevisiae. The recombinant enzyme exhibits similar kinetic behaviour to that of the native enzyme purified from S. cerevisiae. This ter-reactant dimeric enzyme shows Michaelis-Menten kinetics only with IMP. l-Aspartate and GTP display a weak negative co-operativity (Hill coefficient 0. 8-0.9). This negative co-operativity has not yet been reported for adenylosuccinate synthases from other organisms. Another unusual feature of the enzyme from S. cerevisiae is its negligible inhibition by adenine nucleotides and its pronounced inhibition by Cl(-) ions.  (+info)

Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. (4/71)

Electrically stimulated pacing of cultured cardiomyocytes serves as an experimentally convenient and physiologically relevant in vitro model of cardiac hypertrophy. Electrical pacing triggers a signaling cascade that results in the activation of the muscle-specific Adss1 gene and the repression of the nonmuscle Adss2 isoform. Activation of the Adss1 gene involves the calcineurin-mediated dephosphorylation of NFAT3, allowing its translocation to the nucleus, where it can directly participate in Adss1 gene activation. Mutational studies show that an NFAT binding site located in the Adss1 5'-flanking region is essential for this activation. Electrical pacing also results in the increased synthesis of GATA4, another critical cardiac transcription factor required for Adss1 gene expression. MEF2C also produces transactivation of the Adss1 gene reporter in control and paced cardiac myocytes. Using the Adss1 gene as a model, these studies are the first to demonstrate that electrical pacing activates the calcineurin/NFAT3 and GATA4 pathways as a means of regulating cardiac gene expression.  (+info)

Investigation of various genotype characteristics for inosine accumulation in Escherichia coli W3110. (5/71)

For the derivation of an inosine-overproducing strain from the wild type microorganism, it is known that the addition of an adenine requirement, removal of purine nucleoside hydrolyzing activity, removal of the feedback inhibition, and repression of key enzymes in the purine nucleotides biosynthetic pathway are essential. Thus, the disruption of purA (adenine requirement), deoD (removal of purine nucleosides phosphorylase activity), purR (derepression of the regulation of purine nucleotides biosynthetic pathway), and the insensitivity of the feedback inhibition of phosphoribosylpyrophosphate (PRPP) amidotransferase by adenosine 5'-monophosphate (AMP) and guanosine 5'-monophosphate (GMP) were done in the Escherichia coli strain W3110, and then the inosine productivity was estimated. In the case of using a plasmid harboring the PRPP amidotransferase gene (purF) that encoded a desensitized PRPP amidotransferase, purF disrupted mutants were used as the host strains. It was found that the innovation of the four genotypes brought about a small amount of inosine accumulation. Furthermore, an adenine auxotrophic mutant of E. coli showed inappropriate adenine use because its growth could not respond efficiently to the concentration of adenine added. As the presence of adenosine deaminase is well known in E. coli and it is thought to be involved in adenine use, a mutant disrupted adenosine deaminase gene (add) was constructed and tested. The mutant, which is deficient in purF, purA, deoD, purR, and add genes, and harboring the desensitized purF as a plasmid, accumulated about 1 g of inosine per liter. Although we investigated the effects of purR disruption and purF gene improvement, unexpectedly an increase in the inosine productivity could not be found with this mutant.  (+info)

Recombinant mouse muscle adenylosuccinate synthetase: overexpression, kinetics, and crystal structure. (6/71)

Vertebrates possess two isozymes of adenylosuccinate synthetase. The acidic isozyme is similar to the synthetase from bacteria and plants, being involved in the de novo biosynthesis of AMP, whereas the basic isozyme participates in the purine nucleotide cycle. Reported here is the first instance of overexpression and crystal structure determination of a basic isozyme of adenylosuccinate synthetase. The recombinant mouse muscle enzyme purified to homogeneity in milligram quantities exhibits a specific activity comparable with that of the rat muscle enzyme isolated from tissue and K(m) parameters for GTP, IMP, and l-aspartate (12, 45, and 140 microm, respectively) similar to those of the enzyme from Escherichia coli. The mouse muscle and E. coli enzymes have similar polypeptide folds, differing primarily in the conformation of loops, involved in substrate recognition and stabilization of the transition state. Residues 65-68 of the muscle isozyme adopt a conformation not observed in any previous synthetase structure. In its new conformation, segment 65-68 forms intramolecular hydrogen bonds with residues essential for the recognition of IMP and, in fact, sterically excludes IMP from the active site. Observed differences in ligand recognition among adenylosuccinate synthetases may be due in part to conformational variations in the IMP pocket of the ligand-free enzymes.  (+info)

IMP Alone Organizes the Active Site of Adenylosuccinate Synthetase from Escherichia coli. (7/71)

A complete set of substrate/substrate analogs of adenylosuccinate synthetase from Escherichia coli induces dimer formation and a transition from a disordered to an ordered active site. The most striking of the ligand-induced effects is the movement of loop 40-53 by up to 9 A. Crystal structures of the partially ligated synthetase, which either combine IMP and hadacidin or IMP, hadacidin, and Mg(2+)-pyrophosphate, have ordered active sites, comparable with the fully ligated enzyme. More significantly, a crystal structure of the synthetase with IMP alone exhibits a largely ordered active site, which includes the 9 A movement of loop 40-53 but does not include conformational adjustments to backbone carbonyl 40 (Mg(2+) interaction element) and loop 298-304 (L-aspartate binding element). Interactions involving the 5'-phosphoryl group of IMP evidently trigger the formation of salt links some 30 A away. The above provides a structural basis for ligand binding synergism, effects on k(cat) due to mutations far from the site of catalysis, and the complete loss of substrate efficacy due to minor alterations of the 5'-phosphoryl group of IMP.  (+info)

Determinants of L-aspartate and IMP recognition in Escherichia coli adenylosuccinate synthetase. (8/71)

Adenylosuccinate synthetase governs the first committed step in the de novo synthesis of AMP. Mutations of conserved residues in the synthetase from Escherichia coli reveal significant roles for Val(273) and Thr(300) in the recognition of l-aspartate, even though these residues do not or cannot hydrogen bond with the substrate. The mutation of Thr(300) to alanine increases the K(m) for l-aspartate by 30-fold. In contrast, its mutation to valine causes no more than a 4-fold increase in the K(m) for l-aspartate, while increasing k(cat) by 3-fold. Mutations of Val(273) to alanine, threonine, or asparagine increase the K(m) for l-aspartate from 15- to 40-fold, and concomitantly decrease the K(i) for dicarboxylate analogues of l-aspartate by up to 40-fold. The above perturbations are comparable with those resulting from the elimination of a hydrogen bond between the enzyme and substrate: alanine mutations of Thr(128) and Thr(129) increase the K(m) for IMP by up to 30-fold and the alanine mutation of Thr(301) abolishes catalysis supported by l-aspartate, but has no effect on catalysis supported by hydroxylamine. Structure-based mechanisms, by which the above residues influence substrate recognition, are presented.  (+info)

This gene encodes a member of the adenylosuccinate synthase family of proteins. The encoded muscle-specific enzyme plays a role in the purine nucleotide cycle by catalyzing the first step in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP). Mutations in this gene may cause adolescent onset distal myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016 ...
TY - JOUR. T1 - Role of purine synthesis on renal function. T2 - effect of adenylosuccinate synthetase inhibition.. AU - Lien, Y. H.. AU - Lai, L. W.. AU - Cheung, C.. AU - Patterson, D.. AU - Chan, L.. PY - 1991. Y1 - 1991. UR - http://www.scopus.com/inward/record.url?scp=0026298144&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0026298144&partnerID=8YFLogxK. M3 - Article. C2 - 1807901. AN - SCOPUS:0026298144. VL - 95. SP - 112. EP - 119. JO - Contributions to Nephrology. JF - Contributions to Nephrology. SN - 0302-5144. ER - ...
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family (333 aa ...
1CG4: Mechanistic implications from crystalline complexes of wild-type and mutant adenylosuccinate synthetases from Escherichia coli.
1CG3: Mechanistic implications from crystalline complexes of wild-type and mutant adenylosuccinate synthetases from Escherichia coli.
ID D1YV79_METPS Unreviewed; 337 AA. AC D1YV79; DT 09-FEB-2010, integrated into UniProtKB/TrEMBL. DT 09-FEB-2010, sequence version 1. DT 11-DEC-2019, entry version 67. DE RecName: Full=Adenylosuccinate synthetase {ECO:0000256,HAMAP-Rule:MF_00011, ECO:0000256,RuleBase:RU000520}; DE Short=AMPSase {ECO:0000256,HAMAP-Rule:MF_00011}; DE Short=AdSS {ECO:0000256,HAMAP-Rule:MF_00011}; DE EC=6.3.4.4 {ECO:0000256,HAMAP-Rule:MF_00011, ECO:0000256,RuleBase:RU000520}; DE AltName: Full=IMP--aspartate ligase {ECO:0000256,HAMAP-Rule:MF_00011}; GN Name=purA {ECO:0000256,HAMAP-Rule:MF_00011, GN ECO:0000313,EMBL:BAI60351.1}; GN OrderedLocusNames=MCP_0279 {ECO:0000313,EMBL:BAI60351.1}; OS Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / OS SANAE). OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia; OC Methanocellales; Methanocellaceae; Methanocella. OX NCBI_TaxID=304371 {ECO:0000313,EMBL:BAI60351.1, ECO:0000313,Proteomes:UP000001882}; RN [1] {ECO:0000313,Proteomes:UP000001882} RP ...
K. Eaazhisai, R. Jayalakshmi, P. Gayathri, R. P. Anand, K. Sumathy, H. Balaram and M. R. N. Murthy, Crystal structure of fully-ligated adenylosuccinate synthetase from Plasmodium falciparum, Journal of Molecular Biology 335, 1251 - 1264 (2004 ...
K. Eaazhisai, R. Jayalakshmi, P. Gayathri, R. P. Anand, K. Sumathy, H. Balaram and M. R. N. Murthy, Crystal structure of fully-ligated adenylosuccinate synthetase from Plasmodium falciparum, Journal of Molecular Biology 335, 1251 - 1264 (2004 ...
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Adenylosuccinate lyase is an enzyme of fumarase superfamily that participates in the purine biosynthetic pathway, catalysing the nonhydrolytic cleavage of succinyl groups from SAICA ribotide and adenylosuccinate. Enzyme defects are associated with a
SWISS-MODEL Repository entry for A8Q0E3 (PURA_MALGO), Adenylosuccinate synthetase. Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)(Dandruff-associated fungus)
Spontaneous mutants arise among nondividing populations of Escherichia coli in apparent response to selective conditions. In this report we investigate several hypotheses to account for the role of selection in the production of these directed or adaptive mutations. We found that the Lac+ phenotypes of some mutants that arise late after lactose selection are due to suppressor mutations that are unlinked to the mutant lacZ allele; thus the production of these Lac+ mutants does not require an information flow from successful proteins back to the DNA that encodes them. Transcriptional induction of the lac operon, even in the presence of another, utilizable carbon source, did not stimulate the occurrence of Lac+ mutants in the absence of lactose, indicating that the role of the selective agent is not merely to induce transcription. The absence of two DNA repair pathways-methyl-directed mismatch repair and alkylation repair-also did not result in an accumulation of Lac+ mutants in the absence of ...
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Definition of adenylosuccinate lyase. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Adenylosuccinate lyase (ASL) catalyzes 2 reactions in the de novo synthesis of purine nucleotides. In humans, point mutations of this enzyme are associated with mental retardation, autism, and muscle wasting. The sequence of B. subtilis ASL is 27% identical and 17% similar to the human enzyme. We have cloned, expressed, and purified B. subtilis ASL; the crystal structure of a 73% homologous bacterial enzyme is known (PDB #lc3u). We separately mutated 2 amino acids in the B. subtilis ASL (M10L & N276C) equivalent to the mutations identified in human ASL deficiency (M26L & R303C). The purified M10L and N276C possess specific activities of 0.86 and 0.38 units/mg, respectively, as compared to 1.56 units/mg for wild type (WT) enzyme. Both enzymes are similar to WT in conformation and oligomeric state as indicated by circular dichroism and light scattering. The Km for adenylosuccinate (SAMP) is not appreciably different between M1OL (5.6 uM) and WT (4.9 uM); and the pH dependence of Vmax is also ...
Berry, A and Vamplew, P (2004) PoD Can Mutate: A Simple Dynamic Directed Mutation Approach for Genetic Algorithms. In: AISAT2004: International Conference on Artificial Intelligence in Science and Technology, 21-25 November 2004, Hobart, Tasmania, Australia. ...
Adenylosuccinate Lyase; Catalyzes Two Steps In The de Novo Purine Nucleotide Biosynthetic Pathway; Expression Is Repressed By Adenine And Activated By Bas1p And Pho2p; Mutations In Human Ortholog ADSL Cause Adenylosuccinase Deficiency
Adenylosuccinate Lyase; Catalyzes Two Steps In The de Novo Purine Nucleotide Biosynthetic Pathway; Expression Is Repressed By Adenine And Activated By Bas1p And Pho2p; Mutations In Human Ortholog ADSL Cause Adenylosuccinase Deficiency
Banerjee, Sanchari and Agrawal, Monika J and Mishra, Diptimayee and Sharan, Siddharth and Balaram, Hemalatha and Savithri, Handanhal S and Murthy, Mathur RN (2014) Structural and kinetic studies on adenylosuccinate lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme. In: FEBS JOURNAL, 281 (6). pp. 1642-1658. Chittori, Sagar and Simanshu, Dhirendra Kumar and Banerjee, Sanchari and Murthy, Ambika Mosale Venkatesh and Mathivanan, Subashini and Savithri, Handanahal Subbarao and Murthy, Mathur Ramabhadrashastry Narasimha (2013) Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): Insights from kinetic and crystallographic studies. In: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834 (10). pp. 2036-2044. ...
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A good complement to a junk DNA FAQ would be a mechanisms of mutation FAQ, which I dont think exists anywhere. People seem to treat mutation as some kind of magically process and therefore get mislead into all kinds of directed mutation, etc. stuff ...
A good complement to a junk DNA FAQ would be a mechanisms of mutation FAQ, which I dont think exists anywhere. People seem to treat mutation as some kind of magically process and therefore get mislead into all kinds of directed mutation, etc. stuff ...
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Terms of use. Disclaimer. Privacy Statement.. The information contained on this site is for general informational purposes only. It is not a substitute for expert medical advice, and does not take your medical history or specific circumstances into consideration. Always seek your doctors advice if you have a medical or health-related condition. While every effort has been made to ensure that the above information was correct at the time of writing; medical knowledge is constantly being reviewed and updated, and the above information may therefore be superseded by additional knowledge.. ...
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TY - JOUR. T1 - Genetic demonstration of bidirectionality in the high affinity purine base transporter of mutant mouse S49 cells.. AU - Beck, J. T.. AU - Ullman, B.. N1 - Copyright: Medline is the source for the citation and abstract of this record.. PY - 1987/2/15. Y1 - 1987/2/15. N2 - A mutant cell line was selected from wild type S49 lymphoblasts that expressed a novel high affinity purine base transport system not found in parental cells or any other mammalian cell line (Aronow, B., Toll, D., Patrick, J., Hollingsworth, P., McCartan, K., and Ullman, B. (1986) Mol. Cell. Biol. 6, 2957-2962). In order to determine whether this nucleobase transport system was bidirectional, mutant cell lines possessing this high affinity base transport capability were derived from a nucleoside transport-deficient derivative of an adenylosuccinate synthetase-deficient S49 cell line. The resulting progeny excreted significantly greater amounts of purine into the cell culture medium than parental cells. This ...
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PCR can be used very effectively to modify DNA. Such modification may include the addition of restriction enzyme sites (in order to facilitate cloning requirements) or regulatory elements (e.g., the addition of promoter sequences to a DNA cistron). A further type of modification can be the generation of desired site directed mutations in a gene, inclusive of sequence alterations, additions or deletions.. Cycle-sequencing, a modification of the classical di-deoxy sequencing method pioneered by Fred Sanger in the early 1980s, uses the principles of PCR to rapidly perform sequence reactions in a thermal cycler. For PCR-directed diagnostics, it is for example, possible to work with crude samples and minute amounts of material that may include degraded templates, blood, sperm, tissue, individual hairs, etc.. With the advances in molecular biology, the analysis of the genetic material of pathogens has complemented or replaced serological methods for diagnostics, epidemiology and taxonomy. There are ...
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Bouchet, P.; Rosenberg, G. (2017). Ancilla pura G. B. Sowerby III, 1892. In: MolluscaBase (2017). Accessed through: World Register of Marine Species at http://marinespecies.org/aphia.php/aphia.php?p=taxdetails&id=465650 on 2017-12- ...
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Terms of use. Disclaimer. Privacy Statement.. The information contained on this site is for general informational purposes only. It is not a substitute for expert medical advice, and does not take your medical history or specific circumstances into consideration. Always seek your doctors advice if you have a medical or health-related condition. While every effort has been made to ensure that the above information was correct at the time of writing; medical knowledge is constantly being reviewed and updated, and the above information may therefore be superseded by additional knowledge.. ...
The effect of 3-mercaptopicolinate, an inhibitor of phosphoenolpyruvate carboxykinase [GTP:oxaloacetate carboxy-lyase (transphosphorylating), EC 4.1.1.32], was tested on NH3 formation via the purine nucleotide cycle and glutamate dehydrogenase (EC 1.4.1.2). NH3 excretion in rats increased 70-fold after 48 h of NH4Cl feeding, from 12.2 +/- 4.5 to 862 +/- 190 mumol/mg of creatinine. At 4 h after a single intraperitoneal injection of 3-mercaptopicolinate into NH4Cl-fed rats, NH3 excretion was inhibited by 93%. Kidneys of NH4Cl-fed plus 3-mercaptopicolinate-treated rats, compared with those of NH4Cl-fed rats, showed a 3.5-fold increase in the content of IMP, 5-fold increase in adenylosuccinate, 4-fold increase in aspartate, and a 30% increase in AMP. 3-Mercaptopicolinate completely inhibited NH3 and glucose formation from glutamate in tubules from acidotic rats and NH3 formation from aspartate in kidney perfusion experiments. When transamination in tubules was prevented by ...
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"Entrez Gene: Adenylosuccinate synthase like 1". Retrieved 2018-04-09. Sun H, Li N, Wang X, Chen T, Shi L, Zhang L, Wang J, Wan ... Adenylosuccinate synthase like 1 is a protein that in humans is encoded by the ADSSL1 gene. This gene encodes a member of the ... adenylosuccinate synthase family of proteins. The encoded muscle-specific enzyme plays a role in the purine nucleotide cycle by ... T, Cao X (January 2005). "Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from ...
First, GTP hydrolysis fuels the addition of aspartate to IMP by adenylosuccinate synthase, substituting the carbonyl oxygen for ... This step is catalyzed by adenylosuccinate lyase. Inosine monophosphate is converted to guanosine monophosphate by the ... a nitrogen and forming the intermediate adenylosuccinate. Fumarate is then cleaved off forming adenosine monophosphate. ...
... this is subsequently acted upon by adenylosuccinate synthase and adenylosuccinate lyase, in a two step process, to convert it ... kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum". Biochimica et Biophysica Acta (BBA) - ...
GMP back into IMP adenylosuccinate synthase converts IMP to adenylosuccinate adenylosuccinate lyase converts adenylosuccinate ... AICAR + fTHF → FAICAR + THF The last step is catalyzed by Inosine monophosphate synthase. FAICAR → IMP + H2O In eukaryotes the ... CAIR + L-Aspartate + ATP → SAICAR + ADP + Pi The eight is catalyzed by adenylosuccinate lyase. SAICAR → AICAR + Fumarate The ... IMP dehydrogenase (IMPDH) converts IMP into XMP GMP synthase converts XMP into GMP GMP reductase converts ...
... adenylosuccinate synthase, adenine phosphoribosyltransferases, and guanine phosphoribosyltransferases. The human subjects ...
The enzyme adenylosuccinate synthase carries out the reaction by the addition of aspartate to IMP and requires the input of ... Adenylosuccinate lyase deficiency Purine nucleotide cycle Figures 20.4 and 20.7 in Textbook of Biochemistry, with clinical ... Adenylosuccinate is an intermediate in the interconversion of purine nucleotides inosine monophosphate (IMP) and adenosine ...
Humans express two adenylosuccinate synthase isozymes: Adenylosuccinate+synthase at the US National Library of Medicine Medical ... In molecular biology, Adenylosuccinate synthase (or adenylosuccinate synthetase) (EC 6.3.4.4.) is an enzyme that plays an ... Adenylosuccinate synthetase has been characterised from various sources ranging from Escherichia coli (gene purA) to vertebrate ... Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known ...
... adenylosuccinate synthase MeSH D08.811.464.259.200 - amide synthases MeSH D08.811.464.259.200.200 - aspartate-ammonia ligase ... riboflavin synthase MeSH D08.811.913.225.825 - spermidine synthase MeSH D08.811.913.225.912 - spermine synthase MeSH D08.811. ... nitric oxide synthase type i MeSH D08.811.682.664.500.772.500 - nitric oxide synthase type ii MeSH D08.811.682.664.500.772.750 ... glycogen synthase kinases MeSH D08.811.913.696.620.682.700.429.500 - glycogen synthase kinase 3 MeSH D08.811.913.696.620.682. ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ... This entry also includes folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate and cyanophycin synthetase ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ... Carbamoyl phosphate synthase (CPSase) is a heterodimeric enzyme composed of a small and a large subunit (with the exception of ... Carbamoyl phosphate synthase has three main steps in its mechanism and is, in essence, irreversible.[4] ... "Inhibition of carbamoyl-phosphate synthase (ammonia) by Tris and Hepes. Effect on Ka for N-acetylglutamate" (PDF). Biochem. J ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ... In enzymology, a phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) is an enzyme that catalyzes the chemical reaction ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Phosphoribosylformylglycinamidine_synthase&oldid=808965560" ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ...
Phosphoribosylaminoimidazolesuccinocarboxamide synthase. *IMP synthase. IMP→AMP:. *Adenylosuccinate synthase. *Adenylosuccinate ... positive regulation of nitric-oxide synthase activity. • folic acid metabolic process. • tetrahydrobiopterin biosynthetic ... "Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase". Biochimica et Biophysica ... "Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase". Biochimica et Biophysica ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ... Asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4, asparagine synthetase (glutamine-hydrolysing), glutamine-dependent ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Asparagine_synthase_(glutamine-hydrolysing)&oldid=917335771" ...
Phosphoribosylaminoimidazolesuccinocarboxamide synthase. *IMP synthase. IMP→AMP:. *Adenylosuccinate synthase. *Adenylosuccinate ... Bailey, CJ (2009). "Orotic aciduria and uridine monophosphate synthase: a reappraisal". Journal of Inherited Metabolic Disease ... Glycolysis → Pyruvate decarboxylation → Citric acid cycle → Oxidative phosphorylation (electron transport chain + ATP synthase) ... and then is methylated by thymidylate synthase to create thymidine.[1] ...
Adenylosuccinate synthase. *AdoMet MTase. *Adrenocorticotropic hormone. *AFTPH. *AGCS family. *Agrin. *AHSA2. *Protein kinase B ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ... "Synthases and ligases". chem.qmul.ac.uk. Archived from the original on October 15, 2012. Retrieved July 28, 2013.. .mw-parser- ... Under one definition, synthases do not use energy from nucleoside triphosphates (such as ATP, GTP, CTP, TTP, and UTP), whereas ... It is also said that a synthase is a lyase (a lyase is an enzyme that catalyzes the breaking of various chemical bonds by means ...
An example of such a conformational disease is ALAD porphyria, which results from a mutation of porphobilinogen synthase that ... Palenchar, Jennifer Brosius; Colman, Roberta F. (2003). "Characterization of a Mutant Bacillus subtilis Adenylosuccinate Lyase ... The one protein that is established to function as a morpheein is porphobilinogen synthase, though there are suggestions ... An inhibitor of porphobilinogen synthase with this mechanism of action has been documented. The morpheein model of allosteric ...
... adenylosuccinate synthase EC 6.3.4.5: argininosuccinate synthase EC 6.3.4.6: urea carboxylase EC 6.3.4.7: ribose-5-phosphate- ... arginine b-lactam-synthase EC 6.3.4.1: GMP synthase. Now included in EC 6.3.5.2, GMP synthase (glutamine-hydrolysing). EC 6.3. ... imidazole ribonucleotide synthase EC 6.3.4.19: tRNAIle-lysidine synthase EC 6.3.4.20: 7-cyano-7-deazaguanine synthase EC 6.3. ... glutathionylspermidine synthase EC 6.3.1.9: trypanothione synthase EC 6.3.1.10: adenosylcobinamide-phosphate synthase EC 6.3. ...
11-diene synthase EC 4.2.3.25: S-linalool synthase EC 4.2.3.26: R-linalool synthase EC 4.2.3.27: isoprene synthase EC 4.2.3.28 ... adenylosuccinate lyase EC 4.3.2.3: ureidoglycolate lyase EC 4.3.2.4: purine imidazole-ring cyclase EC 4.3.2.5: ... d-cadinene synthase EC 4.2.3.14: pinene synthase EC 4.2.3.15: myrcene synthase EC 4.2.3.16: (4S)-limonene synthase EC 4.2.3.17 ... chorismate synthase EC 4.2.3.6: trichodiene synthase EC 4.2.3.7: pentalenene synthase EC 4.2.3.8: casbene synthase EC 4.2.3.9: ...
... via adenylosuccinate (SAMP). ... Thymidylate synthase inhibitor (Fluorouracil#. *Capecitabine#. ...
Adenylosuccinate lyase deficiency. *Adermatoglyphia. *Adhesive capsulitis of shoulder. *Adie syndrome. *Adipose tissue neoplasm ... 6-Pyruvoyltetrahydropterin synthase deficiency. *8p23.1 duplication syndrome. *9q34 deletion syndrome. *13q deletion syndrome ...
Humans express two adenylosuccinate synthase isozymes: Adenylosuccinate+synthase at the US National Library of Medicine Medical ... In molecular biology, Adenylosuccinate synthase (or adenylosuccinate synthetase) (EC 6.3.4.4.) is an enzyme that plays an ... Adenylosuccinate synthetase has been characterised from various sources ranging from Escherichia coli (gene purA) to vertebrate ... Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known ...
Adenylosuccinate synthase (EC 6.3.4.4) catalyzes the first reaction of AMP biosynthesis at IMP branching point. Previous ... Adenylosuccinate synthase (EC 6.3.4.4) catalyzes the first reaction of AMP biosynthesis at IMP branching point. Previous ... separated two isozymes of adenylosuccinate synthase in rat liver and characterized that the acidic isozyme has a lower Km for ... Ikegami T., Natsumeda Y., Weber G. (1989) Isozyme Shift of Adenylosuccinate Synthase in Rat and Human Neoplasms. In: Mikanagi K ...
Browse our Adenylosuccinate Synthase product catalog backed by our Guarantee+. ... Diseases related to Adenylosuccinate Synthase. Discover more about diseases related to Adenylosuccinate Synthase.. Substance- ... PTMs for Adenylosuccinate Synthase. Learn more about PTMs related to Adenylosuccinate Synthase.. Phosphorylation. ... Bioinformatics Tool for Adenylosuccinate Synthase. Discover related pathways, diseases and genes to Adenylosuccinate Synthase. ...
... ... 1016946-inosine-triphosphate-protects-against-ribavirin-induced-adenosine-triphosphate-loss-by-adenylosuccinate-synthase- ...
... in human erythrocytes or recombinant human adenylosuccinatesynthase (ADSS). RBV-induced adenosine triphosphate (ATP) reduction ...
Adenylosuccinate synthase. 1. 2.29. 0.0008. 0.005. AMP deaminase. 1. 0.002. 1. 1. ...
Adenylosuccinate synthase antibody Rabbit Polyclonal Hu, Ms, Rat ICC/IF, IHC-P, WB ...
adenylosuccinate synthase activity Source: MGI ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for the ... Adenylosuccinate lyase (Adsl), Adenylosuccinase (Adsl), Adenylosuccinate lyase (Adsl), Adenylosuccinate lyase (Adsl). This ... Adenylosuccinate synthetase isozyme 1 (Adssl1), Adenylosuccinate synthetase (Adss), Adenylosuccinate synthetase isozyme 2 ( ... Adenylosuccinate synthetase isozyme.... Adenylosuccinate synthetase isozyme 1, AMPSase 1, AdSS 1, EC 6.3.4.4 (Adenylosuccinate ...
adenylosuccinate synthase activity Source: UniProtKB ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for ... IPR042109, Adenylosuccinate_synth_dom1. IPR042110, Adenylosuccinate_synth_dom2. IPR042111, Adenylosuccinate_synth_dom3. ... IPR042109, Adenylosuccinate_synth_dom1. IPR042110, Adenylosuccinate_synth_dom2. IPR042111, Adenylosuccinate_synth_dom3. ... IPR001114, Adenylosuccinate_synthetase. IPR027529, AdSS_2_vert. IPR027417, P-loop_NTPase. PANTHERi. PTHR11846, PTHR11846, ...
adenylosuccinate synthase converts IMP to adenylosuccinate. *adenylosuccinate lyase converts adenylosuccinate into AMP ... GMP synthase converts XMP into GMP. In enzymology, a GMP synthase (glutamine-hydrolysing) (EC 6.3.5.2) is an enzyme that ... CTPS - CTP synthase 1 CTPS2 - CTP synthase 2 Pyrimidine synthesis inhibitors are used in active moderate to severe rheumatoid ... CTP synthase. cytidine 5triphosphate(CTP). Glutamine and ATP are used. The first three enzymes are all coded by the same gene ...
DR GO; GO:0004019; F:adenylosuccinate synthase activity; IEA:UniProtKB-UniRule. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB ... DR InterPro; IPR042109; Adenylosuccinate_synth_dom1. DR InterPro; IPR001114; Adenylosuccinate_synthetase. DR InterPro; ... DE RecName: Full=Adenylosuccinate synthetase {ECO:0000256,HAMAP-Rule:MF_00011, ECO:0000256,RuleBase:RU000520}; DE Short=AMPSase ... Belongs to the adenylosuccinate synthetase family. CC {ECO:0000256,HAMAP-Rule:MF_00011, ECO:0000256,RuleBase:RU000520}. CC ...
100767083 Adss; adenylosuccinate synthase 100751825 Adssl1; adenylosuccinate synthase like 1 100689060 Adsl; adenylosuccinate ... adenylosuccinate synthase [EC:6.3.4.4] K01939 purA; adenylosuccinate synthase [EC:6.3.4.4] K01756 purB; adenylosuccinate lyase ... 100758127 Nos1; nitric oxide synthase 1 100760062 Nos2; nitric oxide synthase 2 100769961 Nos3; nitric oxide synthase 3 ... nitric-oxide synthase, brain [EC:1.14.13.39] K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39] K13242 NOS3; nitric- ...
Adenylosuccinate synthase involved in purine nucleotide biosynthesis; localized to the cytoplasm, also binds to the DNA ... Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5monophosphate during ...
adenylosuccinate synthase [Source:HGNC Symbol;Acc:292]. Mouse Orthologue:. Adss. Mouse Description:. adenylosuccinate ... Adenylosuccinate synthetase isozyme 2 [Source:UniProtKB/Swiss-Prot;Acc:Q568F6]. Human Orthologue:. ADSS. Human Description:. ...
ADSSL1; adenylosuccinate synthase like 1 [KO:K01939] [EC:6.3.4.4]. 159 ADSS; adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4] ... GMPS; guanine monophosphate synthase [KO:K01951] [EC:6.3.5.2]. 2766 GMPR; guanosine monophosphate reductase [KO:K00364] [EC:1.7 ... ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]. 471 ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide ... PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]. 10606 PAICS; phosphoribosylaminoimidazole ...
Adenylosuccinate synthase like 1. *Adenylosuccinate synthetase. *Adenylosuccinate synthetase isozyme 1. *AdSS 1 ...
"Entrez Gene: Adenylosuccinate synthase like 1". Retrieved 2018-04-09. Sun H, Li N, Wang X, Chen T, Shi L, Zhang L, Wang J, Wan ... Adenylosuccinate synthase like 1 is a protein that in humans is encoded by the ADSSL1 gene. This gene encodes a member of the ... adenylosuccinate synthase family of proteins. The encoded muscle-specific enzyme plays a role in the purine nucleotide cycle by ... T, Cao X (January 2005). "Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from ...
Description adenylosuccinate synthase 2 Also known as ADEH, ADSS, ADSS 2 Species Homo sapiens ...
Adenylosuccinate synthase like 1. AGER. Advanced glycosylation end-product specific receptor. AKAP5. A-kinase anchoring protein ...
Adenylosuccinate synthase like 1. Aliases:. Not Available. RefSeq:. NM_214820. Ensembl:. ENSDARG00000009867 ...
Mudd SH et al (1985) The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet 37:1- ... Albertini E, Koziel R, Durr A, Neuhaus M, Jansen-Durr P (2012) Cystathionine beta synthase modulates senescence of human ... Zhao JY et al (2012) A functional variant in the cystathionine beta-synthase gene promoter significantly reduces congenital ... Akahoshi N et al (2014) Neutral aminoaciduria in cystathionine beta-synthase-deficient mice; an animal model of homocystinuria ...
2. Adenylosuccinate synthetase isozyme 1. General function:. Involved in adenylosuccinate synthase activity. Specific function: ...
2. Adenylosuccinate synthetase isozyme 2. General function:. Involved in adenylosuccinate synthase activity. Specific function: ... 3. Adenylosuccinate synthetase isozyme 1. General function:. Involved in adenylosuccinate synthase activity. Specific function: ... 1. Adenylosuccinate lyase. General function:. Involved in catalytic activity. Specific function:. Not Available. Gene Name:. ... parallel deficiency with adenylosuccinate and succinyl-AICAR in profoundly retarded patients and non-parallel deficiency in a ...
adenylosuccinate synthase. 33247_at. 10213. PSMD14. proteasome (prosome, macropain).... 33332_at. 33394_at. 55308. DDX19A. DEAD ...
carbamoyl-phosphate synthase 1, mitochondrial. 158. 158. ADSL. adenylosuccinate lyase. 159. 159. ADSS. adenylosuccinate ...
OMIM: ADENYLOSUCCINATE SYNTHASE-LIKE 1; ADSSL1*Gene Ontology: Adssl1 *Mouse Phenome DB: Adssl1 *UCSC: Chr.12:112,620,047- ... adenylosuccinate synthetase like 1. Synonyms: Adss. Gene nomenclature, locus information, and GO, OMIM, and PMID associations ...
Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function. ...
Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function; ...
... adenylosuccinate synthase [EC:6.3.4.4] K01490 AMPD; AMP deaminase [EC:3.5.4.6] K00856 E2.7.1.20; adenosine kinase [EC:2.7.1.20 ... phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:4.1.1.21 6.3.2.6] K01756 purB; adenylosuccinate lyase [EC:4.3.2.2 ... 113790332 GMP synthase [glutamine-hydrolyzing]-like 113790347 GMP reductase 1-like 113791309 guanylate kinase-like 113788644 ... 113791481 adenylosuccinate synthetase-like 113794000 AMP deaminase 2-like 113788513 adenosine kinase-like 113788514 adenosine ...
6.3.4.2 CTP synthase (glutamine hydrolysing) 6.3.4.3 formate---tetrahydrofolate ligase 6.3.4.4 adenylosuccinate synthase ...
  • There are currently no images for Adenylosuccinate Lyase Antibody (NBP2-89878AF594). (novusbio.com)
  • The structures of methylisocitrate lyase, methylcitrate synthase, acetate kinase, propionate kinase and threonine deaminase that are overexpressed when Salmonella typhimurium is grown on propionate as the sole source of carbon have been determined. (ibab.ac.in)
  • The eight is catalyzed by adenylosuccinate lyase . (rug.nl)
  • 7 Adenylosuccinate Synthase (ADSS) Kits ELISA de 3 fabricants sont disponibles sur www.anticorps-enligne.fr. (anticorps-enligne.fr)
  • The blood-derived RNA levels of the adenylosuccinate synthase ( ADSS ) and ataxia telangiectasia mutated ( ATM ) genes were found to be down- and up-regulated, respectively, in schizophrenics compared with controls, and ADSS and ATM were among eight biomarker genes to discriminate schizophrenics from normal controls. (biomedcentral.com)
  • Antigen standard for adenylosuccinate synthase (ADSS) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid (OriGene Technologies, Inc.) and then lysed in RIPA Buffer. (abbiotec.com)
  • Adenylosuccinate synthase (ADSS) catalyzes the first committed step of AMP synthesis. (biomedcentral.com)
  • Adenylosuccinate synthase like 1 is a protein that in humans is encoded by the ADSSL1 gene. (wikipedia.org)
  • ADSSL1 is a muscle isozyme of adenylosuccinate synthase (EC 6.3.4.4), which catalyzes the initial reaction in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP) (Sun et al. (fishersci.com)
  • separated two isozymes of adenylosuccinate synthase in rat liver and characterized that the acidic isozyme has a lower K m for IMP than the basic isozyme. (springer.com)
  • 7 These findings directed our attention to the neoplastic expression of the isozyme program of adenylosuccinate synthase in cancer tissues. (springer.com)
  • The present study shows the consistent pattern of the isozyme shift to the acidic adenylosuccinate synthase in rat experimental tumors, human hepatocellular carcinoma and colon adenocarcinoma. (springer.com)
  • Ikegami T., Natsumeda Y., Weber G. (1989) Isozyme Shift of Adenylosuccinate Synthase in Rat and Human Neoplasms. (springer.com)
  • The fourth is catalyzed by phosphoribosylformylglycinamidine synthase . (rug.nl)
  • This gene encodes a member of the adenylosuccinate synthase family of proteins. (wikipedia.org)
  • Several proteins that are conserved in Euryarchaeota and most bacteria are unexpectedly missing in A. pernix , including the entire set of de novo purine biosynthesis enzymes, the GTPase FtsZ (a key component of the bacterial and euryarchaeal cell-division machinery), and the tRNA-specific pseudouridine synthase, previously considered universal. (biomedcentral.com)
  • Recombinant mouse muscle adenylosuccinate synthetase: overexpression, kinetics, and crystal structure. (nih.gov)
  • The seventh is catalyzed by phosphoribosylaminoimidazolesuccinocarboxamide synthase . (rug.nl)
  • SIMILARITY: Belongs to the adenylosuccinate synthetase family. (univ-lyon1.fr)
  • X-ray crystal structures of triosephosphate isomerase, adenylosuccinate synthase and hypoxanthine guanine phosphoribosyl transferase from the malaria parasite Plasmodium falciparum have been determined. (ibab.ac.in)
  • Alanosine, whose ribonucleotide derivative is a potent inhibitor of adenylosuccinate synthetase, had no effect on the growth or hypoxanthine incorporation in T. foetus, which may be due to the lack of converion of alanosine to the ribonucleotide because of the absence of de novo purine nucleotide synthesis in parasites. (elsevier.com)
  • Utility of P. falciparum hypoxanthine-guanine-phosphoribosyltransferase, adenylosuccinate synthase, dihydroorotate dehydrogenase, thymidylate synthase-dihydrofolate reductase, cysteine and aspartic proteases have been elaborated in detail. (bvsalud.org)
  • This entry also includes folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate and cyanophycin synthetase that catalyses the biosynthesis of the cyanobacterial reserve material multi-L-arginyl-poly-L-aspartate ( cyanophycin ). (wikipedia.org)
  • Humans express two adenylosuccinate synthase isozymes: Adenylosuccinate+synthase at the US National Library of Medicine Medical Subject Headings (MeSH) Poland BW, Silva MM, Serra MA, Cho Y, Kim KH, Harris EM, Honzatko RB (December 1993). (wikipedia.org)
  • Y. Matsuda, H. Shiraki, H. Ogawa, and H. Nakagawa, Change in content of adenylosuccinate synthetase isozymes during liver regeneration in rats, Biochim. (springer.com)
  • Adenylosuccinate synthetase has been characterised from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. (wikipedia.org)
  • Discover related pathways, diseases and genes to Adenylosuccinate Synthase. (novusbio.com)
  • Crystal structure of adenylosuccinate synthetase from Escherichia coli. (wikipedia.org)
  • Chemical modification of adenylosuccinate synthetase from Escherichia coli with phenylglyoxal resulted in an inhibition of enzyme activity with a second-order rate constant of 13.6 M -1 min -1 . (uthscsa.edu)
  • Fromm, H. J. / Evidence for an arginine residue at the substrate binding site of Escherichia coli adenylosuccinate synthetase as studied by chemical modification and site-directed mutagenesis . (uthscsa.edu)
  • alanosyl IMP and N-carbamyll-alanosine did not inhibit adenylosuccinate synthetase to any prominent degree, whereas the metabolite generated by SAICAR synthetase powerfully inhibited this enzyme, with a K i , of 0.3μM. (elsevier.com)
  • Of the enzymes involved in the metabolism of l-aspartic acid, adenylosuccinate synthetase (EC 6.3.4.4). (elsevier.com)
  • Adenylosuccinate synthase (EC 6.3.4.4) catalyzes the first reaction of AMP biosynthesis at IMP branching point. (springer.com)
  • Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase. (nih.gov)
  • The last step is catalyzed by Inosine monophosphate synthase . (rug.nl)
  • Adenylosuccinate synthase, active site (IPR033128) Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. (ebi.ac.uk)
  • Based on genome annotation results and literature reports, a new DHA synthesis pathway based on a polyketide synthase (PKS) system was detected in S. limacinum . (biomedcentral.com)
  • In molecular biology, Adenylosuccinate synthase (or adenylosuccinate synthetase) (EC 6.3.4.4. (wikipedia.org)
  • In order to determine whether this nucleobase transport system was bidirectional, mutant cell lines possessing this high affinity base transport capability were derived from a nucleoside transport-deficient derivative of an adenylosuccinate synthetase-deficient S49 cell line. (elsevier.com)