Adenylosuccinate Synthase: A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyzes the synthesis of adenylosuccinate from GTP; IMP; and aspartate with the formation of orthophosphate and GDP. EC 6.3.4.4.Adenylosuccinate Lyase: An enzyme that, in the course of purine ribonucleotide biosynthesis, catalyzes the conversion of 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole to 5'-phosphoribosyl-4-carboxamide-5-aminoimidazole and the conversion of adenylosuccinic acid to AMP. EC 4.3.2.2.Inosine Monophosphate: Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.Purine-Pyrimidine Metabolism, Inborn ErrorsPurine Nucleotides: Purines attached to a RIBOSE and a phosphate that can polymerize to form DNA and RNA.Saccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.Saccharomyces cerevisiae Proteins: Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.Hydroxymethyl and Formyl Transferases: Enzymes that catalyze the transfer of hydroxymethyl or formyl groups. EC 2.1.2.Methanomicrobiales: An order of anaerobic, highly specialized methanogens, in the kingdom EURYARCHAEOTA. Its organisms are nonmotile or motile, with cells occurring as coccoid bodies, pseudosarcina, or rods. Families include METHANOMICROBIACEAE, Methanocorpusculaceae, and Methanospirillaceae.Platyhelminths: A phylum of acoelomate, bilaterally symmetrical flatworms, without a definite anus. It includes three classes: Cestoda, Turbellaria, and Trematoda.Ethanolaminephosphotransferase: An enzyme that catalyzes reversibly the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to yield phosphatidylethanolamine (cephalin) and CMP. The enzyme is found in the endoplasmic reticulum. EC 2.7.8.1.Central AmericaDual-Specificity Phosphatases: A sub-class of protein tyrosine phosphatases that contain an additional phosphatase activity which cleaves phosphate ester bonds on SERINE or THREONINE residues that are located on the same protein.MicroRNAs: Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.Streptomyces griseus: An actinomycete from which the antibiotics STREPTOMYCIN, grisein, and CANDICIDIN are obtained.3' Untranslated Regions: The sequence at the 3' end of messenger RNA that does not code for product. This region contains transcription and translation regulating sequences.Protein Tyrosine Phosphatases: An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.Insectivora: An order of insect eating MAMMALS including MOLES; SHREWS; HEDGEHOGS and tenrecs.Cyclin-Dependent Kinases: Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.Metabolome: The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.Metabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Inosine NucleotidesPoly I: A group of inosine ribonucleotides in which the phosphate residues of each inosine ribonucleotide act as bridges in forming diester linkages between the ribose moieties.Hypoxanthines: Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.Abbreviations as Topic: Shortened forms of written words or phrases used for brevity.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Aminoimidazole Carboxamide: An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. Compounded with orotic acid, it is used to treat liver diseases.Peptide Synthases: Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine groups.Societies, Pharmaceutical: Societies whose membership is limited to pharmacists.Simbu virus: A species in the ORTHOBUNYAVIRUS genus of the family BUNYAVIRIDAE family. Previously a large group of serotypes, most are now considered separate species.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Methylurea Compounds: Urea compounds which are substituted with one or more methyl groups.Silk: A continuous protein fiber consisting primarily of FIBROINS. It is synthesized by a variety of INSECTS and ARACHNIDS.Spiders: Arthropods of the class ARACHNIDA, order Araneae. Except for mites and ticks, spiders constitute the largest order of arachnids, with approximately 37,000 species having been described. The majority of spiders are harmless, although some species can be regarded as moderately harmful since their bites can lead to quite severe local symptoms. (From Barnes, Invertebrate Zoology, 5th ed, p508; Smith, Insects and Other Arthropods of Medical Importance, 1973, pp424-430)Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Vocabulary, Controlled: A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)Gene Ontology: Sets of structured vocabularies used for describing and categorizing genes, and gene products by their molecular function, involvement in biological processes, and cellular location. These vocabularies and their associations to genes and gene products (Gene Ontology annotations) are generated and curated by the Gene Ontology Consortium.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Phosphoribosylaminoimidazolecarboxamide Formyltransferase: An enzyme that catalyzes the conversion of aminoimidazole-4-carboxamide ribonucleotide to 5-formyl-aminoimidazole-4-carboxamide ribonucleotide in the purine de novo synthesis pathway. It requires the cofactor N(10)-FORMYLTETRAHYDROFOLATE as the formyl donor.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Expressed Sequence Tags: Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.RNA-Binding Proteins: Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.RNA Splicing: The ultimate exclusion of nonsense sequences or intervening sequences (introns) before the final RNA transcript is sent to the cytoplasm.Planarians: Nonparasitic free-living flatworms of the class Turbellaria. The most common genera are Dugesia, formerly Planaria, which lives in water, and Bipalium, which lives on land. Geoplana occurs in South America and California.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Epidermis: The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Turbellaria: A class of free-living freshwater flatworms of North America.Regeneration: The physiological renewal, repair, or replacement of tissue.

Combinatorial interactions regulate cardiac expression of the murine adenylosuccinate synthetase 1 gene. (1/71)

The mammalian heart begins contracting at the linear tube stage during embryogenesis and continuously pumps, nonstop, throughout the entire lifetime of the animal. Therefore, the cardiac energy metabolizing pathways must be properly established and efficiently functioning. While the biochemistry of these pathways is well defined, limited information regarding the regulation of cardiac metabolic genes is available. Previously, we reported that 1.9 kilobase pairs of murine adenylosuccinate synthetase 1 gene (Adss1) 5'-flanking DNA directs high levels of reporter expression to the adult transgenic heart. In this report, we define the 1.9-kilobase pair fragment as a cardiac-specific enhancer that controls correct spatiotemporal expression of a reporter similar to the endogenous Adss1 gene. A 700-base pair fragment within this region activates a heterologous promoter specifically in adult transgenic hearts. Proteins present in a cardiac nuclear extract interact with potential transcription factor binding sites of this region and these cis-acting sites play important regulatory roles in the cardiac expression of this reporter. Finally, we report that several different cardiac transcription factors trans-activate the 1.9HSCAT construct through these sites and that combinations result in enhanced reporter expression. Adss1 appears to be one of the first target genes identified for the bHLH factors Hand1 and Hand2.  (+info)

Effectors of the stringent response target the active site of Escherichia coli adenylosuccinate synthetase. (2/71)

Guanosine 5'-diphosphate 3'-diphosphate (ppGpp), a pleiotropic effector of the stringent response, potently inhibits adenylosuccinate synthetase from Escherichia coli as an allosteric effector and/or as a competitive inhibitor with respect to GTP. Crystals of the synthetase grown in the presence of IMP, hadacidin, NO3-, and Mg2+, then soaked with ppGpp, reveal electron density at the GTP pocket which is consistent with guanosine 5'-diphosphate 2':3'-cyclic monophosphate. Unlike ligand complexes of the synthetase involving IMP and GDP, the coordination of Mg2+ in this complex is octahedral with the side chain of Asp13 in the inner sphere of the cation. The cyclic phosphoryl group interacts directly with the side chain of Lys49 and indirectly through bridging water molecules with the side chains of Asn295 and Arg305. The synthetase either directly facilitates the formation of the cyclic nucleotide or scavenges trace amounts of the cyclic nucleotide from solution. Regardless of its mode of generation, the cyclic nucleotide binds far more tightly to the active site than does ppGpp. Conceivably, synthetase activity in vivo during the stringent response may be sensitive to the relative concentrations of several effectors, which together exercise precise control over the de novo synthesis of AMP.  (+info)

Adenylosuccinate synthase from Saccharomyces cerevisiae: homologous overexpression, purification and characterization of the recombinant protein. (3/71)

Adenylosuccinate synthase (EC 6.3.4.4) catalyses the first committed step in the synthesis of adenosine. We have overexpressed the cloned gene of Saccharomyces cerevisiae (ADE12) in S. cerevisiae. The recombinant enzyme exhibits similar kinetic behaviour to that of the native enzyme purified from S. cerevisiae. This ter-reactant dimeric enzyme shows Michaelis-Menten kinetics only with IMP. l-Aspartate and GTP display a weak negative co-operativity (Hill coefficient 0. 8-0.9). This negative co-operativity has not yet been reported for adenylosuccinate synthases from other organisms. Another unusual feature of the enzyme from S. cerevisiae is its negligible inhibition by adenine nucleotides and its pronounced inhibition by Cl(-) ions.  (+info)

Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. (4/71)

Electrically stimulated pacing of cultured cardiomyocytes serves as an experimentally convenient and physiologically relevant in vitro model of cardiac hypertrophy. Electrical pacing triggers a signaling cascade that results in the activation of the muscle-specific Adss1 gene and the repression of the nonmuscle Adss2 isoform. Activation of the Adss1 gene involves the calcineurin-mediated dephosphorylation of NFAT3, allowing its translocation to the nucleus, where it can directly participate in Adss1 gene activation. Mutational studies show that an NFAT binding site located in the Adss1 5'-flanking region is essential for this activation. Electrical pacing also results in the increased synthesis of GATA4, another critical cardiac transcription factor required for Adss1 gene expression. MEF2C also produces transactivation of the Adss1 gene reporter in control and paced cardiac myocytes. Using the Adss1 gene as a model, these studies are the first to demonstrate that electrical pacing activates the calcineurin/NFAT3 and GATA4 pathways as a means of regulating cardiac gene expression.  (+info)

Investigation of various genotype characteristics for inosine accumulation in Escherichia coli W3110. (5/71)

For the derivation of an inosine-overproducing strain from the wild type microorganism, it is known that the addition of an adenine requirement, removal of purine nucleoside hydrolyzing activity, removal of the feedback inhibition, and repression of key enzymes in the purine nucleotides biosynthetic pathway are essential. Thus, the disruption of purA (adenine requirement), deoD (removal of purine nucleosides phosphorylase activity), purR (derepression of the regulation of purine nucleotides biosynthetic pathway), and the insensitivity of the feedback inhibition of phosphoribosylpyrophosphate (PRPP) amidotransferase by adenosine 5'-monophosphate (AMP) and guanosine 5'-monophosphate (GMP) were done in the Escherichia coli strain W3110, and then the inosine productivity was estimated. In the case of using a plasmid harboring the PRPP amidotransferase gene (purF) that encoded a desensitized PRPP amidotransferase, purF disrupted mutants were used as the host strains. It was found that the innovation of the four genotypes brought about a small amount of inosine accumulation. Furthermore, an adenine auxotrophic mutant of E. coli showed inappropriate adenine use because its growth could not respond efficiently to the concentration of adenine added. As the presence of adenosine deaminase is well known in E. coli and it is thought to be involved in adenine use, a mutant disrupted adenosine deaminase gene (add) was constructed and tested. The mutant, which is deficient in purF, purA, deoD, purR, and add genes, and harboring the desensitized purF as a plasmid, accumulated about 1 g of inosine per liter. Although we investigated the effects of purR disruption and purF gene improvement, unexpectedly an increase in the inosine productivity could not be found with this mutant.  (+info)

Recombinant mouse muscle adenylosuccinate synthetase: overexpression, kinetics, and crystal structure. (6/71)

Vertebrates possess two isozymes of adenylosuccinate synthetase. The acidic isozyme is similar to the synthetase from bacteria and plants, being involved in the de novo biosynthesis of AMP, whereas the basic isozyme participates in the purine nucleotide cycle. Reported here is the first instance of overexpression and crystal structure determination of a basic isozyme of adenylosuccinate synthetase. The recombinant mouse muscle enzyme purified to homogeneity in milligram quantities exhibits a specific activity comparable with that of the rat muscle enzyme isolated from tissue and K(m) parameters for GTP, IMP, and l-aspartate (12, 45, and 140 microm, respectively) similar to those of the enzyme from Escherichia coli. The mouse muscle and E. coli enzymes have similar polypeptide folds, differing primarily in the conformation of loops, involved in substrate recognition and stabilization of the transition state. Residues 65-68 of the muscle isozyme adopt a conformation not observed in any previous synthetase structure. In its new conformation, segment 65-68 forms intramolecular hydrogen bonds with residues essential for the recognition of IMP and, in fact, sterically excludes IMP from the active site. Observed differences in ligand recognition among adenylosuccinate synthetases may be due in part to conformational variations in the IMP pocket of the ligand-free enzymes.  (+info)

IMP Alone Organizes the Active Site of Adenylosuccinate Synthetase from Escherichia coli. (7/71)

A complete set of substrate/substrate analogs of adenylosuccinate synthetase from Escherichia coli induces dimer formation and a transition from a disordered to an ordered active site. The most striking of the ligand-induced effects is the movement of loop 40-53 by up to 9 A. Crystal structures of the partially ligated synthetase, which either combine IMP and hadacidin or IMP, hadacidin, and Mg(2+)-pyrophosphate, have ordered active sites, comparable with the fully ligated enzyme. More significantly, a crystal structure of the synthetase with IMP alone exhibits a largely ordered active site, which includes the 9 A movement of loop 40-53 but does not include conformational adjustments to backbone carbonyl 40 (Mg(2+) interaction element) and loop 298-304 (L-aspartate binding element). Interactions involving the 5'-phosphoryl group of IMP evidently trigger the formation of salt links some 30 A away. The above provides a structural basis for ligand binding synergism, effects on k(cat) due to mutations far from the site of catalysis, and the complete loss of substrate efficacy due to minor alterations of the 5'-phosphoryl group of IMP.  (+info)

Determinants of L-aspartate and IMP recognition in Escherichia coli adenylosuccinate synthetase. (8/71)

Adenylosuccinate synthetase governs the first committed step in the de novo synthesis of AMP. Mutations of conserved residues in the synthetase from Escherichia coli reveal significant roles for Val(273) and Thr(300) in the recognition of l-aspartate, even though these residues do not or cannot hydrogen bond with the substrate. The mutation of Thr(300) to alanine increases the K(m) for l-aspartate by 30-fold. In contrast, its mutation to valine causes no more than a 4-fold increase in the K(m) for l-aspartate, while increasing k(cat) by 3-fold. Mutations of Val(273) to alanine, threonine, or asparagine increase the K(m) for l-aspartate from 15- to 40-fold, and concomitantly decrease the K(i) for dicarboxylate analogues of l-aspartate by up to 40-fold. The above perturbations are comparable with those resulting from the elimination of a hydrogen bond between the enzyme and substrate: alanine mutations of Thr(128) and Thr(129) increase the K(m) for IMP by up to 30-fold and the alanine mutation of Thr(301) abolishes catalysis supported by l-aspartate, but has no effect on catalysis supported by hydroxylamine. Structure-based mechanisms, by which the above residues influence substrate recognition, are presented.  (+info)

This gene encodes a member of the adenylosuccinate synthase family of proteins. The encoded muscle-specific enzyme plays a role in the purine nucleotide cycle by catalyzing the first step in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP). Mutations in this gene may cause adolescent onset distal myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016 ...
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family (333 aa ...
1CG4: Mechanistic implications from crystalline complexes of wild-type and mutant adenylosuccinate synthetases from Escherichia coli.
1CG3: Mechanistic implications from crystalline complexes of wild-type and mutant adenylosuccinate synthetases from Escherichia coli.
ID D1YV79_METPS Unreviewed; 337 AA. AC D1YV79; DT 09-FEB-2010, integrated into UniProtKB/TrEMBL. DT 09-FEB-2010, sequence version 1. DT 11-DEC-2019, entry version 67. DE RecName: Full=Adenylosuccinate synthetase {ECO:0000256,HAMAP-Rule:MF_00011, ECO:0000256,RuleBase:RU000520}; DE Short=AMPSase {ECO:0000256,HAMAP-Rule:MF_00011}; DE Short=AdSS {ECO:0000256,HAMAP-Rule:MF_00011}; DE EC=6.3.4.4 {ECO:0000256,HAMAP-Rule:MF_00011, ECO:0000256,RuleBase:RU000520}; DE AltName: Full=IMP--aspartate ligase {ECO:0000256,HAMAP-Rule:MF_00011}; GN Name=purA {ECO:0000256,HAMAP-Rule:MF_00011, GN ECO:0000313,EMBL:BAI60351.1}; GN OrderedLocusNames=MCP_0279 {ECO:0000313,EMBL:BAI60351.1}; OS Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / OS SANAE). OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia; OC Methanocellales; Methanocellaceae; Methanocella. OX NCBI_TaxID=304371 {ECO:0000313,EMBL:BAI60351.1, ECO:0000313,Proteomes:UP000001882}; RN [1] {ECO:0000313,Proteomes:UP000001882} RP ...
K. Eaazhisai, R. Jayalakshmi, P. Gayathri, R. P. Anand, K. Sumathy, H. Balaram and M. R. N. Murthy, Crystal structure of fully-ligated adenylosuccinate synthetase from Plasmodium falciparum, Journal of Molecular Biology 335, 1251 - 1264 (2004 ...
Raghubar Pura News: Latest and Breaking News on Raghubar Pura. Explore Raghubar Pura profile at Times of India for photos, videos and latest news of Raghubar Pura. Also find news, photos and videos on aghubar Pura - Page 13
Discover Lifes page about the biology, natural history, ecology, identification and distribution of Augochlora pura - -- Discover Life
Comprar un Suplemento en cápsulas de L Arginina pura y concentrada para entrenar barato L-arginine Fuel 1500mg con envío rápido para mejorar energía.
Discover Lifes page about the biology, natural history, ecology, identification and distribution of Augochlora pura mosieri, female, mandible image
Adenylosuccinate lyase is an enzyme of fumarase superfamily that participates in the purine biosynthetic pathway, catalysing the nonhydrolytic cleavage of succinyl groups from SAICA ribotide and adenylosuccinate. Enzyme defects are associated with a
SWISS-MODEL Repository entry for A8Q0E3 (PURA_MALGO), Adenylosuccinate synthetase. Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)(Dandruff-associated fungus)
Spontaneous mutants arise among nondividing populations of Escherichia coli in apparent response to selective conditions. In this report we investigate several hypotheses to account for the role of selection in the production of these "directed" or "adaptive" mutations. We found that the Lac+ phenotypes of some mutants that arise late after lactose selection are due to suppressor mutations that are unlinked to the mutant lacZ allele; thus the production of these Lac+ mutants does not require an information flow from successful proteins back to the DNA that encodes them. Transcriptional induction of the lac operon, even in the presence of another, utilizable carbon source, did not stimulate the occurrence of Lac+ mutants in the absence of lactose, indicating that the role of the selective agent is not merely to induce transcription. The absence of two DNA repair pathways-methyl-directed mismatch repair and alkylation repair-also did not result in an accumulation of Lac+ mutants in the absence of ...
Pura Botanicals Lolita Face Drops - The Pura Botanicals Lolita Face Drops provide a lightweight and fast-absorbing daily dose of environ
All prices include sales tax, VAT or customs duties for all countries in the world. You will not be charged any extra fees. x ...
Get natural cures for Adenylosuccinate lyase deficiency that can make a difference in your life or the life of someone you love with alternative treatments.
Definition of adenylosuccinate lyase. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Our lab studies hypoxanthine guanine phosphoribosyltransferase and adenylosuccinate synthetase, enzymes involved in purine salvage in the malarial parasite, Plasmodium falciparum. We have also been studying enzymes involved in hemoglobin degradation and glycolysis. Enzymes of these essential pathways are of interest as targets for antimalarial chemotherapy. Protein engineering/ mutagenesis, spectroscopy and X- Ray crystallographic techniques are used to probe the structure, function and dynamics of these enzymes. Other aspects studied include substrate specificity,catalytic and kinetic mechanisms, and protein stability. Insights from these studies would aid the development of new antimalarials.. ...
Adenylosuccinate lyase (ASL) catalyzes 2 reactions in the de novo synthesis of purine nucleotides. In humans, point mutations of this enzyme are associated with mental retardation, autism, and muscle wasting. The sequence of B. subtilis ASL is 27% identical and 17% similar to the human enzyme. We have cloned, expressed, and purified B. subtilis ASL; the crystal structure of a 73% homologous bacterial enzyme is known (PDB #lc3u). We separately mutated 2 amino acids in the B. subtilis ASL (M10L & N276C) equivalent to the mutations identified in human ASL deficiency (M26L & R303C). The purified M10L and N276C possess specific activities of 0.86 and 0.38 units/mg, respectively, as compared to 1.56 units/mg for wild type (WT) enzyme. Both enzymes are similar to WT in conformation and oligomeric state as indicated by circular dichroism and light scattering. The Km for adenylosuccinate (SAMP) is not appreciably different between M1OL (5.6 uM) and WT (4.9 uM); and the pH dependence of Vmax is also ...
Berry, A and Vamplew, P (2004) PoD Can Mutate: A Simple Dynamic Directed Mutation Approach for Genetic Algorithms. In: AISAT2004: International Conference on Artificial Intelligence in Science and Technology, 21-25 November 2004, Hobart, Tasmania, Australia. ...
Adenylosuccinate Lyase; Catalyzes Two Steps In The de Novo Purine Nucleotide Biosynthetic Pathway; Expression Is Repressed By Adenine And Activated By Bas1p And Pho2p; Mutations In Human Ortholog ADSL Cause Adenylosuccinase Deficiency
Adenylosuccinate Lyase; Catalyzes Two Steps In The de Novo Purine Nucleotide Biosynthetic Pathway; Expression Is Repressed By Adenine And Activated By Bas1p And Pho2p; Mutations In Human Ortholog ADSL Cause Adenylosuccinase Deficiency
Banerjee, Sanchari and Agrawal, Monika J and Mishra, Diptimayee and Sharan, Siddharth and Balaram, Hemalatha and Savithri, Handanhal S and Murthy, Mathur RN (2014) Structural and kinetic studies on adenylosuccinate lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme. In: FEBS JOURNAL, 281 (6). pp. 1642-1658. Chittori, Sagar and Simanshu, Dhirendra Kumar and Banerjee, Sanchari and Murthy, Ambika Mosale Venkatesh and Mathivanan, Subashini and Savithri, Handanahal Subbarao and Murthy, Mathur Ramabhadrashastry Narasimha (2013) Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): Insights from kinetic and crystallographic studies. In: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834 (10). pp. 2036-2044. ...
Pura UV-20 Whole House Ultraviolet Filtration System, Offers Point of Use Pura Ultraviolet water system with single, double or tripple stage of filtration for the whole house
A good complement to a junk DNA FAQ would be a mechanisms of mutation FAQ, which I dont think exists anywhere. People seem to treat mutation as some kind of magically process and therefore get mislead into all kinds of directed mutation, etc. stuff ...
A good complement to a junk DNA FAQ would be a mechanisms of mutation FAQ, which I dont think exists anywhere. People seem to treat mutation as some kind of magically process and therefore get mislead into all kinds of directed mutation, etc. stuff ...
C.A.P. Custom Automated Products: PURA VIDA GROW (6-4-3) 4 Liters (Case-4) [BCPGGA] - Organic Gardening - Gardening & Hydroponics Store -
Surgical Gastroenterologist in Roshan Pura. Get guidance to select the best surgical gastroenterology doctor from trusted hospitals Gurgaon, view fees and book appointment on Credihealth
Terms of use. Disclaimer. Privacy Statement.. The information contained on this site is for general informational purposes only. It is not a substitute for expert medical advice, and does not take your medical history or specific circumstances into consideration. Always seek your doctors advice if you have a medical or health-related condition. While every effort has been made to ensure that the above information was correct at the time of writing; medical knowledge is constantly being reviewed and updated, and the above information may therefore be superseded by additional knowledge.. ...
Programa de Termodinamica: Dada la temperatura, presión y propiedades crísticas de una sustancia pura (gas o en condiciones de saturación); Z-Factor calcula: factor de compresibilidad z, volumen, fugacidad y propiedades residuales. Se utilizan las EOS de RK & PR ...
Buy the PURA PhosLock GFO Phosphate Removal Media - 150 gram for your aquarium and read product reviews, watch videos and see detailed specs at MarineDepot.com.
Be adventurous and transform yourself during a week long retreat at one of Pura Vida Adventures Costa Rica Surf and Yoga Retreats
Bouchet, P.; Rosenberg, G. (2017). Ancilla pura G. B. Sowerby III, 1892. In: MolluscaBase (2017). Accessed through: World Register of Marine Species at http://marinespecies.org/aphia.php/aphia.php?p=taxdetails&id=465650 on 2017-12- ...
Womens Winter Ankle Boots with exclusive designs by Pura Lopez. Newest comfortable, warm and ellegant Winter Ankle Boots for Women【 FREE RETURNS 】
a href= http://brickwickprojects.co.uk/buy-norvasc-uk.pdf ,amlodipine online uk,/a, If there's one thing every woman should have in her sartorial arsenal, it's a classic black jumpsuit. For those nights when a dress seems obvious and a playsuit is just too short, a jumpsuit is the perfect alternative. Obviously TOWIE's Jessica Wright agreed with us as she donned this nineties inspired black jumpsuit from Missguided, to celebrate her 28th birthday ...
Terms of use. Disclaimer. Privacy Statement.. The information contained on this site is for general informational purposes only. It is not a substitute for expert medical advice, and does not take your medical history or specific circumstances into consideration. Always seek your doctors advice if you have a medical or health-related condition. While every effort has been made to ensure that the above information was correct at the time of writing; medical knowledge is constantly being reviewed and updated, and the above information may therefore be superseded by additional knowledge.. ...
Monoklonale und polyklonale PURA Antikörper für viele Methoden. Ausgesuchte Qualitäts-Hersteller für PURA Antikörper. Hier bestellen.
The effect of 3-mercaptopicolinate, an inhibitor of phosphoenolpyruvate carboxykinase [GTP:oxaloacetate carboxy-lyase (transphosphorylating), EC 4.1.1.32], was tested on NH3 formation via the purine nucleotide cycle and glutamate dehydrogenase (EC 1.4.1.2). NH3 excretion in rats increased 70-fold after 48 h of NH4Cl feeding, from 12.2 +/- 4.5 to 862 +/- 190 mumol/mg of creatinine. At 4 h after a single intraperitoneal injection of 3-mercaptopicolinate into NH4Cl-fed rats, NH3 excretion was inhibited by 93%. Kidneys of NH4Cl-fed plus 3-mercaptopicolinate-treated rats, compared with those of NH4Cl-fed rats, showed a 3.5-fold increase in the content of IMP, 5-fold increase in adenylosuccinate, 4-fold increase in aspartate, and a 30% increase in AMP. 3-Mercaptopicolinate completely inhibited NH3 and glucose formation from glutamate in tubules from acidotic rats and NH3 formation from aspartate in kidney perfusion experiments. When transamination in tubules was prevented by ...
Our group of pharmacist and fanciers have over 70 years of experience!! We have formulated a unique formula that have provided Amazing results, fertility enhancement using all natural organic ingredients. We recommend using twice a week before...
Summer Ankle Boots from elegant to daring designs by Pura Lopez ✅ Summer & Spring Ankle Boots and Ankle Booties for Women 【 FREE RETURNS 】
Puration, Inc. (USOTC: PURA) today announced the acquisition of a 25-greenhouse grow operation. PURA operates a U.S. Patented Cannabis Extraction process and sells its extracts
References for Abcams Recombinant mouse RCSD 1 protein (ab116533). Please let us know if you have used this product in your publication
References for Abcams Recombinant Mouse APRIL protein (ab50096). Please let us know if you have used this product in your publication
FRAGMENTO. Sin duda alguna, el auge de la "cirug a laparosc pica asistida con la mano" (CLAM) en el colon emerge una vez que los diferentes grupos quir rgicos contempor neos pr cticamente ya hab an estandarizado la t cnica laparosc pica pura.1,2 Sin embargo, la cirug a de colon laparosc pica pura, de alguna manera necesita de una incisi n para extraer la pieza quir rgica y aunque esta incisi n es realmente peque a (5 a 7 cm), en el estricto sentido descriptivo de la t cnica laparosc pica pura, sta es, s lo en donde la pieza quir rgica se extrae sin necesidad de hacer una incisi n en la piel, REFERENCIAS (EN ESTE ART CULO) ...
Files are available under licenses specified on their description page. All structured data from the file and property namespaces is available under the Creative Commons CC0 License; all unstructured text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and the Privacy Policy ...
Just returned from a fantastic 8 night trip to the land of pura vida,and except for a family emergency that brought us home early(all is ok) the trip
Pura e fresca come neve che cade su un foglio di ghiaccio. Usala per abbozzare un progetto e illustrare i tuoi piani: questa penna è lo strumento perfetto quando hai bisogno di assoluta chiarezza di pensiero e visione.. Che penna stai cercando? Quella per tutti i giorni o quella per le grandi occasioni? Quella da usare con gli amici o quella riservata a una persona speciale? Oppure quella che si abbina al vestito verde, alla camicia a righe o al tè nero? Lasciati ispirare o creala come piace a te.. ...
About Pura Vida Plus Cream - Aging reflects many aspect of personality but the first signs of aging simply appears on facial skin which is hard to handle because its uncontrollable and acts much faster than average rate these days. These days aging becomes a serious issue of worry for women due to several reasons like pollutant environmental factors, lack of skin care, excessive use of cosmetic products, stress workloads and lack of proper sleep.. As these things became an indispensable part of our lifestyle so visible aging signs stats showing more often as compared to earlier times. Women really do consider wrinkles, side lines and fine lines a serious trouble for themselves because for them maintaining their beautiful skin is a lifelong endeavor. So to work in a right way you should have an ageless solution to buy you some time to get an ageless beauty.. Pura Vida Plus Cream is all about anti aging benefits but with natural solutions. Its a skincare solution which promises to deliver anti ...
First, GTP hydrolysis fuels the addition of aspartate to IMP by adenylosuccinate synthase, substituting the carbonyl oxygen for ... This step is catalyzed by adenylosuccinate lyase. Inosine monophosphate is converted to guanosine monophosphate by the ... a nitrogen and forming the intermediate adenylosuccinate. Fumarate is then cleaved off forming adenosine monophosphate. ...
GMP back into IMP adenylosuccinate synthase converts IMP to adenylosuccinate adenylosuccinate lyase converts adenylosuccinate ... AICAR + fTHF → FAICAR + THF The last step is catalyzed by Inosine monophosphate synthase. FAICAR → IMP + H2O In eukaryotes the ... CAIR + L-Aspartate + ATP → SAICAR + ADP + Pi The eight is catalyzed by adenylosuccinate lyase. SAICAR → AICAR + Fumarate The ... IMP dehydrogenase (IMPDH) converts IMP into XMP GMP synthase converts XMP into GMP GMP reductase converts ...
The enzyme adenylosuccinate synthase carries out the reaction by the addition of aspartate to IMP and requires the input of ... Adenylosuccinate lyase deficiency Purine nucleotide cycle Figures 20.4 and 20.7 in Textbook of Biochemistry, with clinical ... Adenylosuccinate is an intermediate in the interconversion of purine nucleotides inosine monophosphate (IMP) and adenosine ...
Humans express two adenylosuccinate synthase isozymes: Adenylosuccinate synthase at the US National Library of Medicine Medical ... In molecular biology, Adenylosuccinate synthase (or adenylosuccinate synthetase) (EC 6.3.4.4.) is an enzyme that plays an ... Adenylosuccinate synthetase has been characterised from various sources ranging from Escherichia coli (gene purA) to vertebrate ... Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known ...
... adenylosuccinate synthase MeSH D08.811.464.259.200 --- amide synthases MeSH D08.811.464.259.200.200 --- aspartate-ammonia ... riboflavin synthase MeSH D08.811.913.225.825 --- spermidine synthase MeSH D08.811.913.225.912 --- spermine synthase MeSH ... nitric oxide synthase type i MeSH D08.811.682.664.500.772.500 --- nitric oxide synthase type ii MeSH D08.811.682.664.500.772. ... glycogen synthase kinases MeSH D08.811.913.696.620.682.700.429.500 --- glycogen synthase kinase 3 MeSH D08.811.913.696.620.682. ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ... This entry also includes folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate and cyanophycin synthetase ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ... Carbamoyl phosphate synthase (CPSase) is a heterodimeric enzyme composed of a small and a large subunit (with the exception of ... Carbamoyl phosphate synthase has three main steps in its mechanism and is, in essence, irreversible.[4] ... "Inhibition of carbamoyl-phosphate synthase (ammonia) by Tris and Hepes. Effect on Ka for N-acetylglutamate" (PDF). Biochem. J ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ... In enzymology, a phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) is an enzyme that catalyzes the chemical reaction ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Phosphoribosylformylglycinamidine_synthase&oldid=808965560" ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ...
Phosphoribosylaminoimidazolesuccinocarboxamide synthase. *IMP synthase. IMP→AMP:. *Adenylosuccinate synthase. *Adenylosuccinate ... positive regulation of nitric-oxide synthase activity. • folic acid metabolic process. • tetrahydrobiopterin biosynthetic ... "Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase". Biochimica et Biophysica ... "Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase". Biochimica et Biophysica ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ... Asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4, asparagine synthetase (glutamine-hydrolysing), glutamine-dependent ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Asparagine_synthase_(glutamine-hydrolysing)&oldid=917335771" ...
Phosphoribosylaminoimidazolesuccinocarboxamide synthase. *IMP synthase. IMP→AMP:. *Adenylosuccinate synthase. *Adenylosuccinate ... Bailey, CJ (2009). "Orotic aciduria and uridine monophosphate synthase: a reappraisal". Journal of Inherited Metabolic Disease ... Glycolysis → Pyruvate decarboxylation → Citric acid cycle → Oxidative phosphorylation (electron transport chain + ATP synthase) ... and then is methylated by thymidylate synthase to create thymidine.[1] ...
Adenylosuccinate synthase. *AdoMet MTase. *Adrenocorticotropic hormone. *AFTPH. *AGCS family. *Agrin. *AHSA2. *Protein kinase B ...
Phosphoribosylaminoimidazolesuccinocarboxamide synthase. *IMP synthase. IMP→AMP:. *Adenylosuccinate synthase. *Adenylosuccinate ... Glycolysis → Pyruvate decarboxylation → Citric acid cycle → Oxidative phosphorylation (electron transport chain + ATP synthase) ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ... "Synthases and ligases". chem.qmul.ac.uk. Archived from the original on October 15, 2012. Retrieved July 28, 2013.. .mw-parser- ... Under one definition, synthases do not use energy from nucleoside triphosphates (such as ATP, GTP, CTP, TTP, and UTP), whereas ... It is also said that a synthase is a lyase (a lyase is an enzyme that catalyzes the breaking of various chemical bonds by means ...
An example of such a conformational disease is ALAD porphyria, which results from a mutation of porphobilinogen synthase that ... Palenchar, Jennifer Brosius; Colman, Roberta F. (2003). "Characterization of a Mutant Bacillus subtilis Adenylosuccinate Lyase ... The one protein that is established to function as a morpheein is porphobilinogen synthase, though there are suggestions ... An inhibitor of porphobilinogen synthase with this mechanism of action has been documented. The morpheein model of allosteric ...
... adenylosuccinate synthase EC 6.3.4.5: argininosuccinate synthase EC 6.3.4.6: urea carboxylase EC 6.3.4.7: ribose-5-phosphate- ... arginine b-lactam-synthase EC 6.3.4.1: GMP synthase. Now included in EC 6.3.5.2, GMP synthase (glutamine-hydrolysing). EC 6.3. ... imidazole ribonucleotide synthase EC 6.3.4.19: tRNAIle-lysidine synthase EC 6.3.4.20: 7-cyano-7-deazaguanine synthase EC 6.3. ... glutathionylspermidine synthase EC 6.3.1.9: trypanothione synthase EC 6.3.1.10: adenosylcobinamide-phosphate synthase EC 6.3. ...
11-diene synthase EC 4.2.3.25: S-linalool synthase EC 4.2.3.26: R-linalool synthase EC 4.2.3.27: isoprene synthase EC 4.2.3.28 ... adenylosuccinate lyase EC 4.3.2.3: ureidoglycolate lyase EC 4.3.2.4: purine imidazole-ring cyclase EC 4.3.2.5: ... d-cadinene synthase EC 4.2.3.14: pinene synthase EC 4.2.3.15: myrcene synthase EC 4.2.3.16: (4S)-limonene synthase EC 4.2.3.17 ... chorismate synthase EC 4.2.3.6: trichodiene synthase EC 4.2.3.7: pentalenene synthase EC 4.2.3.8: casbene synthase EC 4.2.3.9: ...
... via adenylosuccinate (SAMP). ... Thymidylate synthase inhibitor (Fluorouracil#. *Capecitabine#. ...
Adenylosuccinate lyase deficiency. *Adermatoglyphia. *Adhesive capsulitis of shoulder. *Adie syndrome. *Adipose tissue neoplasm ... 6-Pyruvoyltetrahydropterin synthase deficiency. *8p23.1 duplication syndrome. *9q34 deletion syndrome. *13q deletion syndrome ...
Humans express two adenylosuccinate synthase isozymes: Adenylosuccinate synthase at the US National Library of Medicine Medical ... In molecular biology, Adenylosuccinate synthase (or adenylosuccinate synthetase) (EC 6.3.4.4.) is an enzyme that plays an ... Adenylosuccinate synthetase has been characterised from various sources ranging from Escherichia coli (gene purA) to vertebrate ... Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known ...
Adenylosuccinate synthase (EC 6.3.4.4) catalyzes the first reaction of AMP biosynthesis at IMP branching point. Previous ... Adenylosuccinate synthase (EC 6.3.4.4) catalyzes the first reaction of AMP biosynthesis at IMP branching point. Previous ... separated two isozymes of adenylosuccinate synthase in rat liver and characterized that the acidic isozyme has a lower Km for ... Ikegami T., Natsumeda Y., Weber G. (1989) Isozyme Shift of Adenylosuccinate Synthase in Rat and Human Neoplasms. In: Mikanagi K ...
... ... 1016946-inosine-triphosphate-protects-against-ribavirin-induced-adenosine-triphosphate-loss-by-adenylosuccinate-synthase- ...
... in human erythrocytes or recombinant human adenylosuccinatesynthase (ADSS). RBV-induced adenosine triphosphate (ATP) reduction ...
adenylosuccinate synthase activity Source: MGI ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for the ... Adenylosuccinate lyase (Adsl), Adenylosuccinase (Adsl), Adenylosuccinate lyase (Adsl), Adenylosuccinate lyase (Adsl). This ... Adenylosuccinate synthetase isozyme 1 (Adssl1), Adenylosuccinate synthetase (Adss), Adenylosuccinate synthetase isozyme 2 ( ... Adenylosuccinate synthetase isozyme.... Adenylosuccinate synthetase isozyme 1, AMPSase 1, AdSS 1, EC 6.3.4.4 (Adenylosuccinate ...
adenylosuccinate synthase activity Source: SGD ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for the ... "Adenylosuccinate synthase from Saccharomyces cerevisiae: homologous overexpression, purification and characterization of the ... "Adenylosuccinate synthase from Saccharomyces cerevisiae: homologous overexpression, purification and characterization of the ... "Adenylosuccinate synthase from Saccharomyces cerevisiae: homologous overexpression, purification and characterization of the ...
Adenylosuccinate synthase antibody Rabbit Polyclonal Hu, Ms, Rat ICC/IF, IHC-P, WB ...
adenylosuccinate synthase converts IMP to adenylosuccinate. *adenylosuccinate lyase converts adenylosuccinate into AMP ... GMP synthase converts XMP into GMP. In enzymology, a GMP synthase (glutamine-hydrolysing) (EC 6.3.5.2) is an enzyme that ... CTPS - CTP synthase 1 CTPS2 - CTP synthase 2 Pyrimidine synthesis inhibitors are used in active moderate to severe rheumatoid ... CTP synthase. cytidine 5triphosphate(CTP). Glutamine and ATP are used. The first three enzymes are all coded by the same gene ...
DR GO; GO:0004019; F:adenylosuccinate synthase activity; IEA:UniProtKB-UniRule. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB ... DR InterPro; IPR042109; Adenylosuccinate_synth_dom1. DR InterPro; IPR001114; Adenylosuccinate_synthetase. DR InterPro; ... DE RecName: Full=Adenylosuccinate synthetase {ECO:0000256,HAMAP-Rule:MF_00011, ECO:0000256,RuleBase:RU000520}; DE Short=AMPSase ... Belongs to the adenylosuccinate synthetase family. CC {ECO:0000256,HAMAP-Rule:MF_00011, ECO:0000256,RuleBase:RU000520}. CC ...
100767083 Adss; adenylosuccinate synthase 100751825 Adssl1; adenylosuccinate synthase like 1 100689060 Adsl; adenylosuccinate ... adenylosuccinate synthase [EC:6.3.4.4] K01939 purA; adenylosuccinate synthase [EC:6.3.4.4] K01756 purB; adenylosuccinate lyase ... 100758127 Nos1; nitric oxide synthase 1 100760062 Nos2; nitric oxide synthase 2 100769961 Nos3; nitric oxide synthase 3 ... nitric-oxide synthase, brain [EC:1.14.13.39] K13241 NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39] K13242 NOS3; nitric- ...
Adenylosuccinate synthase involved in purine nucleotide biosynthesis; localized to the cytoplasm, also binds to the DNA ... Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5monophosphate during ...
adenylosuccinate synthase [Source:HGNC Symbol;Acc:292]. Mouse Orthologue:. Adss. Mouse Description:. adenylosuccinate ... Adenylosuccinate synthetase isozyme 2 [Source:UniProtKB/Swiss-Prot;Acc:Q568F6]. Human Orthologue:. ADSS. Human Description:. ...
ADSSL1; adenylosuccinate synthase like 1 [KO:K01939] [EC:6.3.4.4]. 159 ADSS; adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4] ... GMPS; guanine monophosphate synthase [KO:K01951] [EC:6.3.5.2]. 2766 GMPR; guanosine monophosphate reductase [KO:K00364] [EC:1.7 ... ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]. 471 ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide ... PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]. 10606 PAICS; phosphoribosylaminoimidazole ...
Adenylosuccinate synthase like 1. *Adenylosuccinate synthetase. *Adenylosuccinate synthetase isozyme 1. *AdSS 1 ...
Adenylosuccinate synthase like 1. AGER. Advanced glycosylation end-product specific receptor. AKAP5. A-kinase anchoring protein ...
OMIM: ADENYLOSUCCINATE SYNTHASE-LIKE 1; ADSSL1*Gene Ontology: Adssl1 *Mouse Phenome DB: Adssl1 *UCSC: Chr.12:112,620,047- ... adenylosuccinate synthetase like 1. Synonyms: Adss. Gene nomenclature, locus information, and GO, OMIM, and PMID associations ...
Adenylosuccinate synthase like 1. Aliases:. Not Available. RefSeq:. NM_214820. Ensembl:. ENSDARG00000009867 ...
Mudd SH et al (1985) The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet 37:1- ... Albertini E, Koziel R, Durr A, Neuhaus M, Jansen-Durr P (2012) Cystathionine beta synthase modulates senescence of human ... Zhao JY et al (2012) A functional variant in the cystathionine beta-synthase gene promoter significantly reduces congenital ... Akahoshi N et al (2014) Neutral aminoaciduria in cystathionine beta-synthase-deficient mice; an animal model of homocystinuria ...
2. Adenylosuccinate synthetase isozyme 1. General function:. Involved in adenylosuccinate synthase activity. Specific function: ...
2. Adenylosuccinate synthetase isozyme 2. General function:. Involved in adenylosuccinate synthase activity. Specific function: ... 3. Adenylosuccinate synthetase isozyme 1. General function:. Involved in adenylosuccinate synthase activity. Specific function: ... 1. Adenylosuccinate lyase. General function:. Involved in catalytic activity. Specific function:. Not Available. Gene Name:. ... parallel deficiency with adenylosuccinate and succinyl-AICAR in profoundly retarded patients and non-parallel deficiency in a ...
adenylosuccinate synthase. 33247_at. 10213. PSMD14. proteasome (prosome, macropain).... 33332_at. 33394_at. 55308. DDX19A. DEAD ...
carbamoyl-phosphate synthase 1, mitochondrial. 158. 158. ADSL. adenylosuccinate lyase. 159. 159. ADSS. adenylosuccinate ...
Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function. ...
Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function; ...
6.3.4.2 CTP synthase (glutamine hydrolysing) 6.3.4.3 formate---tetrahydrofolate ligase 6.3.4.4 adenylosuccinate synthase ...
  • The blood-derived RNA levels of the adenylosuccinate synthase ( ADSS ) and ataxia telangiectasia mutated ( ATM ) genes were found to be down- and up-regulated, respectively, in schizophrenics compared with controls, and ADSS and ATM were among eight biomarker genes to discriminate schizophrenics from normal controls. (biomedcentral.com)
  • Antigen standard for adenylosuccinate synthase (ADSS) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid (OriGene Technologies, Inc.) and then lysed in RIPA Buffer. (abbiotec.com)
  • Adenylosuccinate synthase (ADSS) catalyzes the first committed step of AMP synthesis. (biomedcentral.com)
  • separated two isozymes of adenylosuccinate synthase in rat liver and characterized that the acidic isozyme has a lower K m for IMP than the basic isozyme. (springer.com)
  • 7 These findings directed our attention to the neoplastic expression of the isozyme program of adenylosuccinate synthase in cancer tissues. (springer.com)
  • The present study shows the consistent pattern of the isozyme shift to the acidic adenylosuccinate synthase in rat experimental tumors, human hepatocellular carcinoma and colon adenocarcinoma. (springer.com)
  • Ikegami T., Natsumeda Y., Weber G. (1989) Isozyme Shift of Adenylosuccinate Synthase in Rat and Human Neoplasms. (springer.com)
  • This entry also includes folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate and cyanophycin synthetase that catalyses the biosynthesis of the cyanobacterial reserve material multi-L-arginyl-poly-L-aspartate ( cyanophycin ). (wikipedia.org)
  • Several proteins that are conserved in Euryarchaeota and most bacteria are unexpectedly missing in A. pernix , including the entire set of de novo purine biosynthesis enzymes, the GTPase FtsZ (a key component of the bacterial and euryarchaeal cell-division machinery), and the tRNA-specific pseudouridine synthase, previously considered universal. (biomedcentral.com)
  • Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein. (wikipedia.org)
  • Although l-alanosine provokes a rise in the concentration of inosinic acid (IMP) in vitro, pointing to the conclusion that the drug is capable of inhibiting adenylosuccinate synthetase under these circumstances, no such rise was seen in vivo either in tumor or liver. (elsevier.com)