OrganismsDiseasesChemicals and DrugsPhenomena and ProcessesDisciplines and OccupationsInformation Science
Adenylosuccinate LyaseAdenylosuccinate SynthasePurine-Pyrimidine Metabolism, Inborn ErrorsLyasesAminoimidazole CarboxamidePurinesInosine MonophosphateRibonucleotidesAdenosine MonophosphateThermotoga maritimaBacillus subtilisMutation, MissenseMolecular Sequence DataKineticsAmino Acid SequenceDeoxyriboseLesch-Nyhan SyndromePurine-Nucleoside PhosphorylaseMetabolomeMetabolomicsPhosphatesPurine Nucleosides
Adenylosuccinate Lyase
An enzyme that, in the course of purine ribonucleotide biosynthesis, catalyzes the conversion of 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole to 5'-phosphoribosyl-4-carboxamide-5-aminoimidazole and the conversion of adenylosuccinic acid to AMP. EC 4.3.2.2.
Adenylosuccinate Synthase
A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyzes the synthesis of adenylosuccinate from GTP; IMP; and aspartate with the formation of orthophosphate and GDP. EC 6.3.4.4.
Purine-Pyrimidine Metabolism, Inborn Errors
Lyases
A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (Enzyme Nomenclature, 1992) EC 4.
Aminoimidazole Carboxamide
An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. Compounded with orotic acid, it is used to treat liver diseases.
Purines
A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
Inosine Monophosphate
Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
Ribonucleotides
Nucleotides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)
Adenosine Monophosphate
Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
Thermotoga maritima
A rod-shaped bacterium surrounded by a sheath-like structure which protrudes balloon-like beyond the ends of the cell. It is thermophilic, with growth occurring at temperatures as high as 90 degrees C. It is isolated from geothermally heated marine sediments or hot springs. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
Bacillus subtilis
A species of gram-positive bacteria that is a common soil and water saprophyte.
Mutation, Missense
A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Kinetics
The rate dynamics in chemical or physical systems.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Deoxyribose
Lesch-Nyhan Syndrome
An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
Purine-Nucleoside Phosphorylase
An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free purine plus ribose-5-phosphate. EC 2.4.2.1.
Metabolome
The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.
Metabolomics
The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
Phosphates
Inorganic salts of phosphoric acid.
Purine Nucleosides
Purines with a RIBOSE attached that can be phosphorylated to PURINE NUCLEOTIDES.

Capillary electrophoresis for detection of inherited disorders of purine and pyrimidine metabolism. (1/51)

BACKGROUND: Measurement of purine and pyrimidine metabolites presents complex problems for separations currently performed by HPLC and thin-layer chromatography in clinical practice. We developed a novel capillary electrophoresis method for this purpose. METHODS: Separations were performed in 60 mmol/L borate-2-amino-2-methyl-1-propanol-80 mmol/L sodium dodecyl sulfate (pH 9.6) at 35 degrees C. RESULTS: The conditions reported allowed separation of all diagnostic metabolites from major urinary constituents in an analysis time of 3 min and with a separation efficiency of 220 000 theoretical plates/m. The clinically important metabolites were detectable at concentrations of 0.85-4.28 micromol/L. The method was linear over the range 5-500 micromol/L (r >0.99). The within-run and intra- and interday imprecision (CV) was <5%. Characteristic abnormalities were detected in the electropherograms of urine samples from patients with purine and pyrimidine enzyme deficiencies. We provide the electrophoretic and spectral characteristics of many intermediates in purine and pyrimidine metabolism and describe common artifacts from medication and ultraviolet-absorbing compounds. CONCLUSION: Capillary electrophoresis is a valuable screening tool in the detection of inborn errors of purine and pyrimidine metabolism.  (+info)

The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway. (2/51)

BACKGROUND: Adenylosuccinate lyase is an enzyme that plays a critical role in both cellular replication and metabolism via its action in the de novo purine biosynthetic pathway. Adenylosuccinate lyase is the only enzyme in this pathway to catalyze two separate reactions, enabling it to participate in the addition of a nitrogen at two different positions in adenosine monophosphate. Both reactions catalyzed by adenylosuccinate lyase involve the beta-elimination of fumarate. Enzymes that catalyze this type of reaction belong to a superfamily, the members of which are homotetramers. Because adenylosuccinate lyase plays an integral part in maintaining proper cellular metabolism, mutations in the human enzyme can have severe clinical consequences, including mental retardation with autistic features. RESULTS: The 1.8 A crystal structure of adenylosuccinate lyase from Thermotoga maritima has been determined by multiwavelength anomalous dispersion using the selenomethionine-substituted enzyme. The fold of the monomer is reminiscent of other members of the beta-elimination superfamily. However, its active tetrameric form exhibits striking differences in active-site architecture and cleft size. CONCLUSIONS: This first structure of an adenylosuccinate lyase reveals that, along with the catalytic base (His141) and the catalytic acid (His68), Gln212 and Asn270 might play a vital role in catalysis by properly orienting the succinyl moiety of the substrates. We propose a model for the dual activity of adenylosuccinate lyase: a single 180 degrees bond rotation must occur in the substrate between the first and second enzymatic reactions. Modeling of the pathogenic human S413P mutation indicates that the mutation destabilizes the enzyme by disrupting the C-terminal extension.  (+info)

Succinylpurinemic autism: increased sensitivity of defective adenylosuccinate lyase towards 4-hydroxy-2-nonenal. (3/51)

We studied the effect of trans-4-hydroxy-2-nonenal on the wild-type human adenylosuccinate lyase and on the enzyme from a patient compound-heterozygous for two missense mutations (P75A/D397Y; McKusick 103050.0003/103050.0004). Both the enzymes were inhibited by 10-50 microM trans-4-hydroxy-2-nonenal in a concentration-dependent manner by means of a mixed-type co-operative mechanism. A significantly stronger inhibition was noticed in the presence of the defective enzyme. Nonanal and trans-2,3-nonenal inhibited the enzymes to a less extent and at about 10-times higher concentrations. Hydroxylamine reversed the inhibition by trans-4-hydroxy-2-nonenal, trans-2,3-nonenal or nonanal in the case of the wild-type enzyme, but it was ineffective to reverse the inhibition by trans-4-hydroxy-2-nonenal on the defective enzyme. Dithiothreitol slightly decreased the inhibition exerted by trans-4-hydroxy-2-nonenal on both the wild-type and the defective adenylosuccinate lyase, while it did not produce practically any change in the presence of trans-2,3-nonenal or nonanal.  (+info)

Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure and molecular basis for ADSL deficiency in six patients. (4/51)

Adenylosuccinate lyase (ADSL) is a bifunctional enzyme acting in de novo purine synthesis and purine nucleotide recycling. ADSL deficiency is a selectively neuronopathic disorder with psychomotor retardation and epilepsy as leading traits. Both dephosphorylated enzyme substrates, succinylaminoimidazole-carboxamide riboside (SAICAr) and succinyladenosine (S-Ado), accumulate in the cerebrospinal fluid (CSF) of affected individuals with S-Ado/SAICAr concentration ratios proportional to the phenotype severity. We studied the disorder at various levels in a group of six patients with ADSL deficiency. We identified the complete ADSL cDNA and its alternatively spliced isoform resulting from exon 12 skipping. Both mRNA isoforms were expressed in all the tissues studied with the non-spliced form 10-fold more abundant. Both cDNAs were expressed in Escherichia coli and functionally characterized at the protein level. The results showed only the unspliced ADSL to be active. The gene consists of 13 exons spanning 23 kb. The promotor region shows typical features of the housekeeping gene. Eight mutations were identified in a group of six patients. The expression studies of the mutant proteins carried out in an attempt to study genotype-phenotype correlation showed that the level of residual enzyme activity correlates with the severity of the clinical phenotype. All the mutant enzymes studied in vitro displayed a proportional decrease in activity against both of their substrates. However, this was not concordant with strikingly different concentration ratios in the CSF of individual patients. This suggests either different in vivo enzyme activities against each of the substrates and/or their different turnover across the CSF-blood barrier, which may be decisive in determining disease severity.  (+info)

Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency. (5/51)

Adenylosuccinate lyase (ADSL) deficiency (MIM 103050) is an autosomal recessive inborn error of purine synthesis characterized by the accumulation in body fluids of succinylaminoimidazolecarboxamide (SAICA) riboside and succinyladenosine (S-Ado), the dephosphorylated derivatives of the two substrates of the enzyme. Because ADSL-deficient patients display widely variable degrees of psychomotor retardation, we have expressed eight mutated ADSL enzymes as thioredoxin fusions and compared their properties with the clinical and biochemical characteristics of 10 patients. Three expressed mutated ADSL enzymes (M26L, R426H and T450S) were thermolabile, four (A2V, R141W, R303C and S395R) were thermostable and one (del206-218), was inactive. Thermolabile mutations decreased activities with SAICA ribotide (SAICAR) and adenylosuccinate (S-AMP) in parallel, or more with SAICAR than with S-AMP. Patients homozygous for one of these mutations, R426H, displayed similarly decreased ADSL activities in their fibroblasts, S-Ado:SAICA riboside ratios of approximately 1 in their cerebrospinal fluid and were profoundly retarded. With the exception of A2V, thermostable mutations decreased activity with S-AMP to a much more marked extent than with SAICAR. Two unrelated patients homozygous for one of the thermostable mutations, R303C, also displayed a much more marked decrease in the activity of fibroblast ADSL with S-AMP than with SAICAR, had S-Ado:SAICA riboside ratios between 3 and 4 in their cerebrospinal fluid and were mildly retarded. These results suggest that, in some cases, the genetic lesion of ADSL determines the ratio of its activities with S-AMP versus SAICAR, which in turn defines the S-Ado:SAICA riboside ratio and the patients' mental status.  (+info)

Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency. (6/51)

Adenylosuccinate lyase (ADSL; also called "adenylosuccinase") catalyzes two steps in the synthesis of purine nucleotides: (1) the conversion of succinylaminoimidazolecarboxamide ribotide into aminoimidazolecarboxamide ribotide and (2) the conversion of adenylosuccinate into adenosine monophosphate. ADSL deficiency, a recessively inherited disorder, causes variable-but most often severe-mental retardation, frequently accompanied by epilepsy and/or autism. It is characterized by the accumulation, in body fluids, of succinylaminoimidazolecarboxamide riboside and succinyladenosine, the dephosphorylated derivatives of the two substrates of the enzyme. Analysis of the ADSL gene of three unrelated patients with ADSL deficiency, in whom one of the ADSL alleles displayed a normal coding sequence, revealed a -49T-->C mutation in the 5' untranslated region of this allele. Measurements of the amount of mRNA transcribed from the latter allele showed that it was reduced to approximately 33% of that transcribed from the alleles mutated in their coding sequence. Further investigations showed that the -49T-->C mutation provokes a reduction to 25% of wild-type control of promoter function, as evaluated by luciferase activity and mRNA level in transfection experiments. The mutation also affects the binding of nuclear respiratory factor 2 (NRF-2), a known activator of transcription, as assessed by gel-shift studies. Our findings indicate that a mutation of a regulatory region of the ADSL gene might be an unusually frequent cause of ADSL deficiency, and they suggest a role for NRF-2 in the gene regulation of the purine biosynthetic pathway.  (+info)

Splicing graphs and EST assembly problem. (7/51)

MOTIVATION: The traditional approach to annotate alternative splicing is to investigate every splicing variant of the gene in a case-by-case fashion. This approach, while useful, has some serious shortcomings. Recent studies indicate that alternative splicing is more frequent than previously thought and some genes may produce tens of thousands of different transcripts. A list of alternatively spliced variants for such genes would be difficult to build and hard to analyse. Moreover, such a list does not show the relationships between different transcripts and does not show the overall structure of all transcripts. A better approach would be to represent all splicing variants for a given gene in a way that captures the relationships between different splicing variants. RESULTS: We introduce the notion of the splicing graph that is a natural and convenient representation of all splicing variants. The key difference with the existing approaches is that we abandon the linear (sequence) representation of each transcript and replace it with a graph representation where each transcript corresponds to a path in the graph. We further design an algorithm to assemble EST reads into the splicing graph rather than assembling them into each splicing variant in a case-by-case fashion.  (+info)

The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase deficiencies. (8/51)

Adenylosuccinate lyase is a homotetramer that catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide (SAICAR). Several point mutations in the gene encoding the enzyme have been implicated in human disease. Bacillus subtilis adenylosuccinate lyase was used as a model system in which mutations were constructed corresponding to those mutations associated with severe human adenylosuccinate lyase deficiency. Site-directed mutagenesis was utilized to construct amino acid substitutions in B. subtilis adenylosuccinate lyase; Met(10), Ile(123), and Thr(367) were replaced by Leu, Trp, and Arg, respectively, and the altered enzymes were expressed in Escherichia coli. These purified enzymes containing amino acid substitutions were found to have substantial catalytic activity and exhibit relatively small changes in their kinetic parameters. The major deviations from the wild-type-like behavior were observed upon biophysical characterization. All of these enzymes with amino acid replacements are associated with marked thermal instability. I123W adenylosuccinate lyase exhibits notable changes in the circular dichroism spectra, and a native gel electrophoresis pattern indicative of some protein aggregation. T367R also exhibits alterations at the quarternary level, as reflected in native gel electrophoresis. Experimental results, combined with homology modeling, suggest that the altered enzymes are primarily structurally impaired. The enzyme instability was found to be lessened by subunit complementation with the wild-type enzyme, under mild conditions; these studies may have implications for the in vivo behavior of adenylosuccinate lyase in heterozygous patients. Residues Met(10), Ile(123), and Thr(367) appear to be located in regions of the enzyme important for maintaining the structural integrity required for a stable, functional enzyme.  (+info)

RCSB PDB - 2VD6: Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP...RCSB PDB - 2VD6: Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP...
2VD6: Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate.
https://www.rcsb.org/structure/2VD6
Natural cure for Adenylosuccinate lyase deficiency and alternative treatments
Get natural cures for Adenylosuccinate lyase deficiency that can make a difference in your life or the life of someone you love with alternative treatments.
http://www.naturalcurefor.com/treatments/adenylosuccinate-lyase-deficiency
Inhibition of defective adenylosuccinate lyase by HNE: A neurological disease that may be affected by oxidative stress - IOS...Inhibition of defective adenylosuccinate lyase by HNE: A neurological disease that may be affected by oxidative stress - IOS...
Adenylosuccinate lyase is an enzyme of fumarase superfamily that participates in the purine biosynthetic pathway, catalysing the nonhydrolytic cleavage of succinyl groups from SAICA ribotide and adenylosuccinate. Enzyme defects are associated with a
https://content.iospress.com/articles/biofactors/bio00765
Adenylosuccinate lyase definition | Drugs.comAdenylosuccinate lyase definition | Drugs.com
Definition of adenylosuccinate lyase. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
https://www.drugs.com/dict/adenylosuccinate-lyase.html
Mthe 1218 - Adenylosuccinate lyase - Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) - Mthe 1218...Mthe 1218 - Adenylosuccinate lyase - Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) - Mthe 1218...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
http://www.uniprot.org/uniprot/A0B8H3
RCSB PDB - 1F1O: STRUCTURAL STUDIES OF ADENYLOSUCCINATE LYASES Literature Report PageRCSB PDB - 1F1O: STRUCTURAL STUDIES OF ADENYLOSUCCINATE LYASES Literature Report Page
1F1O: The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.
http://www.rcsb.org/pdb/explore/litView.do?structureId=1F1O
ADE13 (YLR359W) Result Summary | BioGRIDADE13 (YLR359W) Result Summary | BioGRID
Adenylosuccinate Lyase; Catalyzes Two Steps In The de Novo Purine Nucleotide Biosynthetic Pathway; Expression Is Repressed By Adenine And Activated By Bas1p And Pho2p; Mutations In Human Ortholog ADSL Cause Adenylosuccinase Deficiency
https://thebiogrid.org/31620/summary/saccharomyces-cerevisiae/ade13.html
ADE13 (YLR359W) Result Summary | BioGRIDADE13 (YLR359W) Result Summary | BioGRID
Adenylosuccinate Lyase; Catalyzes Two Steps In The de Novo Purine Nucleotide Biosynthetic Pathway; Expression Is Repressed By Adenine And Activated By Bas1p And Pho2p; Mutations In Human Ortholog ADSL Cause Adenylosuccinase Deficiency
https://thebiogrid.org/31620/table/saccharomyces-cerevisiae/ade13.html
HHMI-Sponsored UD Undergraduates at the Experimental Biology Meetings, Orlando 2001HHMI-Sponsored UD Undergraduates at the Experimental Biology Meetings, Orlando 2001
Adenylosuccinate lyase (ASL) catalyzes 2 reactions in the de novo synthesis of purine nucleotides. In humans, point mutations of this enzyme are associated with mental retardation, autism, and muscle wasting. The sequence of B. subtilis ASL is 27% identical and 17% similar to the human enzyme. We have cloned, expressed, and purified B. subtilis ASL; the crystal structure of a 73% homologous bacterial enzyme is known (PDB #lc3u). We separately mutated 2 amino acids in the B. subtilis ASL (M10L & N276C) equivalent to the mutations identified in human ASL deficiency (M26L & R303C). The purified M10L and N276C possess specific activities of 0.86 and 0.38 units/mg, respectively, as compared to 1.56 units/mg for wild type (WT) enzyme. Both enzymes are similar to WT in conformation and oligomeric state as indicated by circular dichroism and light scattering. The Km for adenylosuccinate (SAMP) is not appreciably different between M1OL (5.6 uM) and WT (4.9 uM); and the pH dependence of Vmax is also ...
http://www1.udel.edu/chem/white/HHMI/Orlando2001a.htm
Browse by Author - [email protected]
Banerjee, Sanchari and Agrawal, Monika J and Mishra, Diptimayee and Sharan, Siddharth and Balaram, Hemalatha and Savithri, Handanhal S and Murthy, Mathur RN (2014) Structural and kinetic studies on adenylosuccinate lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme. In: FEBS JOURNAL, 281 (6). pp. 1642-1658. Chittori, Sagar and Simanshu, Dhirendra Kumar and Banerjee, Sanchari and Murthy, Ambika Mosale Venkatesh and Mathivanan, Subashini and Savithri, Handanahal Subbarao and Murthy, Mathur Ramabhadrashastry Narasimha (2013) Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): Insights from kinetic and crystallographic studies. In: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834 (10). pp. 2036-2044. ...
http://eprints.iisc.ernet.in/view/people/Banerjee=3ASanchari=3A=3A.html
SAICAR - What does SAICAR stand for? The Free DictionarySAICAR - What does SAICAR stand for? The Free Dictionary
Looking for online definition of SAICAR or what SAICAR stands for? SAICAR is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms
http://acronyms.thefreedictionary.com/SAICAR
ADSL Composite Endpoint | CDISCADSL Composite Endpoint | CDISC
This is a simplified example ADSL dataset for an AKI trial. It is anticipated that, for many studies, other variables of interest would be included. The dataset includes information needed to derive the studys composite primary endpoint. Not all ADSL variables are shown; this example focuses on specific variables useful for AKI analysis. See the ADaMIG for required ADSL variables. ...
https://www.cdisc.org/kb/examples/adsl-composite-endpoint-86249718
Product data Linksys WAG54GX2-EU Wireless-G ADSL Gateway with SRX200 gateways/controller gateways/controllers (WAG54GX2-SE)Product data Linksys WAG54GX2-EU Wireless-G ADSL Gateway with SRX200 gateways/controller gateways/controllers (WAG54GX2-SE)
PIM product data: Linksys WAG54GX2-EU Wireless-G ADSL Gateway with SRX200 gateways/controller WAG54GX2-SE gateways/controllers Linksys WAG54GX2-EU Wireless-G MIMO VPN ADSL2/2+ Router w/SRX200, compare, review, comparison, specifications, price, brochure, catalog, product information, content syndication, product info, product data, datasheet
https://icecat.us/us/p/linksys/wag54gx2-se/gateways-controllers-WAG54GX2-EU+Wireless-G+ADSL+Gateway+with+SRX200-614258.html
Re: Vilken ADSL?Re: Vilken ADSL?
On Wed, 9 Oct 2002, Adam Huuva wrote: , Kan ni säga vilken ADSL av de leverantörer som levererar över , hela Sverige som är nåt att ha? Vilken är bäst av Telia, Telenordia, , Tele2, Spray?, ev. annan? För användning med debian. Varken de eller någon annan levererar över hela Sverige. Ingen är särskilt bra, det är mer bita i det sura äpplet som gäller, jag hade nog valt BoStream men de är rätt dyra. /Daniel Widerström ...
https://lists.debian.org/debian-user-swedish/2002/10/msg00059.html
Browse public registers | ACCCBrowse public registers | ACCC
On 16 April 2014, the ACCC decided to extend the existing the final access determinations (FADs) for the declared fixed line services (LCS, WLR, LSS, ULLS, PSTN OA (FOAS as of 1 August 2014), PSTN TA (FTAS as of August 1 2014) and the wholesale ADSL service. The ACCC is extending these FADs as it will not be in a position to make the new fixed line services and the wholesale ADSL service FADs prior to their expiration. ...
https://www.accc.gov.au/public-registers/browse-public-registers?sort_by=accc_solr_date&%3Bamp%3Bitems_per_page=10&%3Bamp%3Bf%5B0%5D=accc_solr_date%3A2011&%3Bf%5B0%5D=field_accc_sub_type%3A578&f%5B0%5D=field_accc_sub_type%3A594&f%5B1%5D=field_accc_sub_type%3A520&f%5B2%5D=field_accc_sub_type%3A484&f%5B3%5D=field_accc_sub_type%3A517&f%5B4%5D=field_accc_sub_type%3A536&f%5B5%5D=field_accc_sub_type%3A537&f%5B6%5D=accc_solr_date%3A2011-07&f%5B8%5D=field_accc_sub_type%3A590
Mike Tree • User • The Register ForumsMike Tree • User • The Register Forums
Our road infrastructure has an upto 70mph limit.. My rather old landrover will only do about 50mph, so perhaps I should only pay 71% of the Road Tax for my vehicle.. There are several national speed limit roads near where I live. I defy anyone to drive down them at 60mph, even though that is the therectical limit.. When I bought my latest vehicle, I checked the official fuel consumption figures. Apparently I can get upto 52mpg. Like that will ever happen! Even if I drive like a nun.. These days, most ISPs package their products with download limits, rather than speed.. The upto speed is only the maximum of the technology they are using. They could say they use ADSL, ADSL2 & let the customer work out what speed they are likely to get.. Anybody know who to contact to get my Road Tax refunded?. ...
https://forums.theregister.co.uk/user/6886/
Adenylosuccinate synthetase isozyme 1Adenylosuccinate synthetase isozyme 1
This gene encodes a member of the adenylosuccinate synthase family of proteins. The encoded muscle-specific enzyme plays a role in the purine nucleotide cycle by catalyzing the first step in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP). Mutations in this gene may cause adolescent onset distal myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016 ...
https://pharos.nih.gov/idg/targets/Q8N142
ADSS2 - Adenylosuccinate synthetase isozyme 2 - Homo sapiens (Human) - ADSS2 gene & proteinADSS2 - Adenylosuccinate synthetase isozyme 2 - Homo sapiens (Human) - ADSS2 gene & protein
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
https://www.uniprot.org/uniprot/P30520
Nmar 1421 protein (Nitrosopumilus maritimus) - STRING interaction networkNmar 1421 protein (Nitrosopumilus maritimus) - STRING interaction network
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family (333 aa ...
https://string-db.org/network/436308.Nmar_1421
Jawaharlal Nehru Centre for Advanced Scientific ResearchJawaharlal Nehru Centre for Advanced Scientific Research
K. Eaazhisai, R. Jayalakshmi, P. Gayathri, R. P. Anand, K. Sumathy, H. Balaram and M. R. N. Murthy, Crystal structure of fully-ligated adenylosuccinate synthetase from Plasmodium falciparum, Journal of Molecular Biology 335, 1251 - 1264 (2004 ...
http://www.jncasr.ac.in/publications.php?dept_id=&empid=16&yeartype=2004
Jawaharlal Nehru Centre for Advanced Scientific ResearchJawaharlal Nehru Centre for Advanced Scientific Research
K. Eaazhisai, R. Jayalakshmi, P. Gayathri, R. P. Anand, K. Sumathy, H. Balaram and M. R. N. Murthy, Crystal structure of fully-ligated adenylosuccinate synthetase from Plasmodium falciparum, Journal of Molecular Biology 335, 1251 - 1264 (2004 ...
http://jncasr.ac.in/publications.php?dept_id=&empid=16&yeartype=2004
10 / 100 baseT RJ45 PCB connector with LAN Filter for Adsl, yellow housing10 / 100 baseT RJ45 PCB connector with LAN Filter for Adsl, yellow housing
High quality 10 / 100 baseT RJ45 PCB connector with LAN Filter for Adsl, yellow housing from China, Chinas leading cat6 rj45 jack product, with strict quality control rj45 cat6 connector factories, producing high quality rj45 cat6 connector products.
https://www.rj45transformer.com/china-10_100_baset_rj45_pcb_connector_with_lan_filter_for_adsl_yellow_housing-447781.html
NetGear N600 Wireless-N Dual Band Gigabit ADSL2+ Modem Router (DGND3700-100UKS) | BT ShopNetGear N600 Wireless-N Dual Band Gigabit ADSL2+ Modem Router (DGND3700-100UKS) | BT Shop
NetGear N600 Wireless-N Dual Band Gigabit ADSL2+ Modem Router (DGND3700-100UKS) at great prices. Full product description, technical specifications and customer reviews from BT Shop
https://www.shop.bt.com/products/netgear-n600-wireless-n-dual-band-gigabit-adsl2--modem-router-dgnd3700-100uks-7FF5.html?src=1&utm_source=dabs+migration&utm_medium=redirect&utm_campaign=auto
D-Link ADSL2+ Ethernet Modem 1x10/100 (DSL-320B/UK) | BT ShopD-Link ADSL2+ Ethernet Modem 1x10/100 (DSL-320B/UK) | BT Shop
D-Link ADSL2+ Ethernet Modem 1x10/100 (DSL-320B/UK) at great prices. Full product description, technical specifications and customer reviews from BT Shop
https://www.shop.bt.com/products/d-link-adsl2--ethernet-modem-1x10-100-dsl-320b-uk-5766.html?src=2&utm_source=dabs+migration&utm_medium=redirect&utm_campaign=auto
IE Secure Master 2.10 - Configure modem, ISDN,ADSL and cable for better performance. Repair system setupIE Secure Master 2.10 - Configure modem, ISDN,ADSL and cable for better performance. Repair system setup
Configure modem ISDNADSL and cable for better performance Repair system setup and protect regeditProtect Internet Explorer Clear cookie cache history and password 1Configure modem ISDN ADSL and Cable for better performance 2Set
http://www.filetransit.com/view.php?id=18993
ADSL - PrimePCR Assay and Template | Life Science | Bio-RadADSL - PrimePCR Assay and Template | Life Science | Bio-Rad
Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.
http://www.bio-rad.com/en-us/prime-pcr-assays/gene/adsl-rhesus-monkey
Nimbin - ADSL2+ dropout - Exetel customer help forum
Wholesale supplier estimates the reported service issue will be investigated on or before 27/06/2018 7:00PM. Please ensure suitable access to main distribution frame or the network boundary point is available. Usually when the technician is arranged as a commitment, they dont need to have access inside the premises. However we may need to wait without having further changes or troubleshooting until the technician visit is completed ...
https://forum.exetel.com.au/viewtopic.php?p=323619
ADSL: too far from the CO? Use a second pair? | Electronics ForumsADSL: too far from the CO? Use a second pair? | Electronics Forums
Say if we need a thicker cable to transmit signals better, then one could just add additional strands no? And what if these strands just happened to...
https://www.electronicspoint.com/forums/threads/adsl-too-far-from-the-co-use-a-second-pair.7983/
Issues with Internet | TechPowerUp ForumsIssues with Internet | TechPowerUp Forums
Hi all, Im currently having problems with ny network at home. Im currently using an old (about 5 years old) Belkin router, ADSL 2+ which is connected...
https://www.techpowerup.com/forums/threads/issues-with-internet.179863/
MaxTester 635 | Discontinued spec sheets | EXFOMaxTester 635 | Discontinued spec sheets | EXFO
The MaxTester 635 offers a fast, easy-to-use and cost-effective solution for installation and activation of multiplay services over copper/ADSL2+/VDSL2 and Ethernet.
https://www.exfo.com/en/resources/technical-documentation/discontinued-spec-sheets/maxtester-635-discontinued/
close ] Virus Infection - WhatIsMyIP.com®close ] Virus Infection - WhatIsMyIP.com®
On June my PC was invaded by a virus (probably Rombertik or similar). I could not eliminate it.On August I moved of house and address. I hired a new ADSL
https://www.whatismyip.com/questions/virus-infection/
Neelie Kroes promises an end to the up to broadband speed situation | thinkbroadbandNeelie Kroes promises an end to the up to broadband speed situation | thinkbroadband
While the package does not explicitly say that up to speeds are to be outlawed, a statement by Neelie Kroes suggests that this may be the intent no more up to 30 Megabit deals that in practice just offer 3. The UK already has broadband speeds code of practice but it is voluntary and this new set of rules are defining rights enshrined in law. So what actual data speeds really means is important, but for now that is anyones guess, the existing UK code of practice may be enough, but be compulsory rather than voluntary. Certainly the UK moving to a gaining provider led system for migrations in 2015 ticks the switching box.. We know many who will applaud the end to up to speeds since it will expose real performance of ADSL and VDSL2 based services, but it will also make life harder for the various fixed speed connection services such as cable and FTTH/FTTP/FTTB, since contention and shared access on the backhaul networks is the sole reason that mortals can afford broadband connections at ...
https://www.thinkbroadband.com/news/6403-neelie-kroes-promises-an-end-to-the-up-to-broadband-speed-situation
Tracer: The CRTC, Bell and Metered BillingTracer: The CRTC, Bell and Metered Billing
You have to understand how stupid this is. An independent ISP must pay for their own upstream connection and traffic. They are already paying for the bandwidth used by their customers. Now bell is trying to convince the CRTC, that the leased last mile that the independants use, should also be metered and the ISPs charged. So in essence these ISPs would have to pay double. This is at the same time as Bell has ignored a CRTC ruling telling them to also allow for ADSL2 reselling ...
https://blog.tracer.ca/2009/09/crtc-bell-and-metered-billing.html
L Arginina pura y concentrada para entrenar baratoL Arginina pura y concentrada para entrenar barato
Comprar un Suplemento en cápsulas de L Arginina pura y concentrada para entrenar barato L-arginine Fuel 1500mg con envío rápido para mejorar energía.
https://www.dietespana.com/l-arginina/1766-l-arginine-fuel-1500mg-60-capsulas.html
Pura Ped: DiveSSIPura Ped: DiveSSI
45년 이상 동안 SSI는 세계 전역의 다이버, 다이빙 강사, 다이브 센터 및 리조트에 교육, 스쿠버 다이빙 인증과 교육 재료들을 제공해왔습니다.
https://www.divessi.com/ko/mydiveguide/divesite/155400
Role of purine synthesis on renal function: effect of adenylosuccinate synthetase inhibition.<...
TY - JOUR. T1 - Role of purine synthesis on renal function. T2 - effect of adenylosuccinate synthetase inhibition.. AU - Lien, Y. H.. AU - Lai, L. W.. AU - Cheung, C.. AU - Patterson, D.. AU - Chan, L.. PY - 1991. Y1 - 1991. UR - http://www.scopus.com/inward/record.url?scp=0026298144&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0026298144&partnerID=8YFLogxK. M3 - Article. C2 - 1807901. AN - SCOPUS:0026298144. VL - 95. SP - 112. EP - 119. JO - Contributions to Nephrology. JF - Contributions to Nephrology. SN - 0302-5144. ER - ...
https://arizona.pure.elsevier.com/en/publications/role-of-purine-synthesis-on-renal-function-effect-of-adenylosucci
3Com ADSL Modem PCI LAN (Win 2000) - Device Driver
As a PCI internal modem connection card, the 3Com ADSL Modem PCI LAN (Win 2000) can be connected conveniently to any PCI bus of a personal computer. The device offers users higher connectivity and data transfer rates as compared to similar devices using traditional technologies. It uses a home connectivity technology referred to as ADSL that enables it to have an efficient downstream access line rate of as much as 8 megabytes per second and 1 megabyte per second in the upstream. The 3Com ADSL Modem PCI LAN (Win 2000) has an always-on access feature that puts it a notch higher than dial up modems that rely on wait time. Additionally, the excellent downstream performance eliminates the wait time associated with many dial up modems that need a lot of time in order to support downloading of information. The device is also equipped with mechanisms that facilitate interoperability with DSLAM. It is highly recommended you run a free registry scan for ...
https://www.liutilities.com/device-driver/3com-adsl-modem-pci-lan-win-2000/
17 alpha-hydroxylase/17,20-lyase deficiency: MedlinePlus Genetics17 alpha-hydroxylase/17,20-lyase deficiency: MedlinePlus Genetics
17α-hydroxylase/17,20-lyase deficiency is caused by mutations in the CYP17A1 gene. The protein produced from this gene is involved in the formation of steroid hormones. This group of hormones includes sex hormones such as testosterone and estrogen, which are needed for normal sexual development and reproduction; mineralocorticoids, which help regulate the bodys salt and water balance; and glucocorticoids, which are involved in maintaining blood sugar levels and regulating the bodys response to stress.. Steroid hormones are produced through a series of chemical reactions. The CYP17A1 enzyme performs two important reactions in this process. The enzyme has 17 alpha(α)-hydroxylase activity, which is important for production of glucocorticoids and sex hormones. CYP17A1 also has 17,20-lyase activity, which is integral to the production of sex hormones.. 17α-hydroxylase/17,20-lyase deficiency results from a shortage (deficiency) of both enzyme activities. The amount of remaining enzyme activity ...
https://medlineplus.gov/genetics/condition/17-alpha-hydroxylase-17-20-lyase-deficiency/
SWISSPROT: D1YV79 METPS
ID D1YV79_METPS Unreviewed; 337 AA. AC D1YV79; DT 09-FEB-2010, integrated into UniProtKB/TrEMBL. DT 09-FEB-2010, sequence version 1. DT 11-DEC-2019, entry version 67. DE RecName: Full=Adenylosuccinate synthetase {ECO:0000256,HAMAP-Rule:MF_00011, ECO:0000256,RuleBase:RU000520}; DE Short=AMPSase {ECO:0000256,HAMAP-Rule:MF_00011}; DE Short=AdSS {ECO:0000256,HAMAP-Rule:MF_00011}; DE EC=6.3.4.4 {ECO:0000256,HAMAP-Rule:MF_00011, ECO:0000256,RuleBase:RU000520}; DE AltName: Full=IMP--aspartate ligase {ECO:0000256,HAMAP-Rule:MF_00011}; GN Name=purA {ECO:0000256,HAMAP-Rule:MF_00011, GN ECO:0000313,EMBL:BAI60351.1}; GN OrderedLocusNames=MCP_0279 {ECO:0000313,EMBL:BAI60351.1}; OS Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / OS SANAE). OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia; OC Methanocellales; Methanocellaceae; Methanocella. OX NCBI_TaxID=304371 {ECO:0000313,EMBL:BAI60351.1, ECO:0000313,Proteomes:UP000001882}; RN [1] {ECO:0000313,Proteomes:UP000001882} RP ...
http://pbil.univ-lyon1.fr/cgi-bin/acnuc-search-ac?query=BAI60351&db=SWISSPROT&ident=ACNUC10043
SWISS-MODEL Repository | A8Q0E3
SWISS-MODEL Repository entry for A8Q0E3 (PURA_MALGO), Adenylosuccinate synthetase. Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)(Dandruff-associated fungus)
https://swissmodel.expasy.org/repository/uniprot/A8Q0E3
ASL purified MaxPab rabbit polyclonal antibody (D01P) - (H00000435-D01P) - Products - Abnova
Rabbit polyclonal antibody raised against a full-length human ASL protein. ASL (NP_000039.2, 1 a.a. ~ 464 a.a) full-length human protein. (H00000435-D01P) - Products - Abnova
http://www.abnova.com/products/products_detail.asp?catalog_id=H00000435-D01P
93.139.62.107 - 93-139-62-107.adsl.net.t-com.hr - Croatia - Hrvatski Telekom d.d - IP address geolocation93.139.62.107 - 93-139-62-107.adsl.net.t-com.hr - Croatia - Hrvatski Telekom d.d - IP address geolocation
93.139.62.107 or 93-139-62-107.adsl.net.t-com.hr is an IPv4 address owned by Hrvatski Telekom d.d and located in Zagreb, Croatia (see map)
https://db-ip.com/93.139.62.107
78.3.20.54 - 78-3-20-54.adsl.net.t-com.hr - Croatia - Hrvatski Telekom d.d - IP address geolocation78.3.20.54 - 78-3-20-54.adsl.net.t-com.hr - Croatia - Hrvatski Telekom d.d - IP address geolocation
78.3.20.54 or 78-3-20-54.adsl.net.t-com.hr is an IPv4 address owned by Hrvatski Telekom d.d and located in Zagreb, Croatia (see map)
https://db-ip.com/78.3.20.54
Patent US5519731 - ADSL compatible discrete multi-tone apparatus for mitigation of T1 noise - Google PatentsPatent US5519731 - ADSL compatible discrete multi-tone apparatus for mitigation of T1 noise - Google Patents
An improved discrete multi-tone transmission scheme is describe that contemplates encoding digital data and modulating the encoded data onto a discrete multi-tone signal having a total bandwidth of at least 1.6 MHz. The modulation system is capable of dynamically updating the subcarriers used and the amount of data transmitted on each subcarrier during transmission in order to accommodate real time changes in the line quality over particular subcarriers. In one preferred embodiment of the invention the multi-tone encoding and modulation is done in substantial compliance with the ATIS North American Asymmetric Digital Subscriber Lines standard although a total of 512 subchannels each having a bandwidth of approximately 4.3125 kHz are used. In this system, the subchannels that occur at frequencies above those set forth in the standard are treated similarly to those within the standard range in terms of subcarrier selection criteria. This embodiment contemplates the use of a discrete multi-tone signal
http://www.google.com/patents/US5519731?dq=raman+iyer&ei=oYE3T4ePBKariQKfpoi9Cg
Drunk Nothings: ADSL SEASON 4 - WEEK 1 REVIEW
Now listen up people. I really dont want to do the Costanza Award this year…Im running out of quotes and I have no more Costanza pictures to use. But if we have a repeat performance of this past weekend you will give me no choice. And Im just warning you now if the Costanza Award comes back he will not be happy. I mean seriously….this was a real shit show this weekend. Here are some lowlights: Flacco 34 points, Trent Edwards 22 points, Roy E. Williams 15.5 points, Thomas Jones 27 points, Tony Romo 37 points, and Fred Jackson 21.5 points. What do these guys all have in common? All of them were on the bench and outscored their starting teammates by 14 points or more! Not the way you want to start the year kids ...
https://www.drunknothings.com/2009/09/adsl-season-4-week-1-review.html
Difference between revisions of SpeedTouch ADSL Modem - ArchWikiDifference between revisions of SpeedTouch ADSL Modem - ArchWiki
Which should give you the revision number of your modem. If your modem is revision 0 or 2 you will need the KQD6_3.012 file. If your modem is revision 4, then you will require the ZZZL_3.012 file. Both of these files can be located in this tarball here. You will, later, need the firmware-extractor too, which can be found here. Finally you should check this page to find out the VPI/VCI numbers for your country or ISP. Now you have everything, save a copy of this guide too (in text helps), and copy everything to a USB flash drive, floppy disk (if it fits), or a USB external hard drive, so you can use them while offline. NOTE: Unzip isnt supported in a basic Arch Linux installation, you should unzip any .zip files using another computer or operating system first. ...
https://wiki.archlinux.org/index.php?title=SpeedTouch_ADSL_Modem&diff=205975&oldid=33743
RSAWEB - 2oceansvibe.comRSAWEB - 2oceansvibe.com
RSAWEB Connecting Tomorrow.. In this increasingly digital age it is imperative that businesses and individuals harness the power of the Internet in order to stay ahead. RSAWEB makes the Internet work for you by connecting people, places, platforms and applications to make your life easier, faster and ultimately better.. RSAWEB offers the best in connectivity and hosting products for both businesses and individuals. Whether it is ADSL , Fibre, Mobile Data or Cloud solutions that you are looking for, RSAWEB has a solution to suit your needs and budget.. Since 2001, RSAWEB has grown rapidly, gaining extensive industry experience and expertise while continuously improving their products and pushing boundaries. With great commitment to customer service excellence and in-depth technical understanding, RSAWEB retains partnerships with some of SAs leading companies.. We bridge the gap between IT innovation and everyday life - and the RSAWEB team takes pride in doing this every day. - RSAWEB Director, ...
http://www.2oceansvibe.com/partner/rsaweb/
About Ajurlina - TPG CommunityAbout Ajurlina - TPG Community
TPG Community is a place for customers to find support, ask, answer and talk about TPG products and services including NBN, ADSL2+, FTTB and mobile.
https://community.tpg.com.au/t5/user/viewprofilepage/user-id/27289/user-messages-feed/participations
About Miagoreng - TPG CommunityAbout Miagoreng - TPG Community
TPG Community is a place for customers to find support, ask, answer and talk about TPG products and services including NBN, ADSL2+, FTTB and mobile.
https://community.tpg.com.au/t5/user/viewprofilepage/user-id/32607/user-messages-feed/participations
K6JRF Auto PageK6JRF Auto Page
In my home, the phone line carries both signals. The DSL service consists of 1.5Mbps ADSL which is top speed for my distant location from the Central Office (CO). The measured D/L speed is 1.35Mbps and U/L speed is 0.35Mbps. Not the speediest of DSL service but it works nicely for my needs. Note the white-box labeled Z-Blkr Filter. More about it later ...
https://www.k6jrf.com/DirecTV_DSLFilter.html
Benin Internet Service Providers (ISP) List - IspQuickListBenin Internet Service Providers (ISP) List - IspQuickList
Get your Ideal Internet Connection from the list of Internet Service Providers (ISP) in Benin for 4G, Broadband, DSL, ADSL, Cable..
http://www.ispquicklist.com/internet-service-providers-list-in-Benin.aspx
Linux modem?Linux modem?
I want to make the leap to linux (specifically Redhat 7.2) but Im pretty sure my modem isnt gonna work with it. Can anyone recommend a good modem that I should get? Is an external modem a good bet? Also what about cable/adsl modems, as I think pretty soon in the future Im going to go for broadband, what are peoples experience with getting these to work? thanks a lot, hush
http://www.antionline.com/showthread.php?232304-Linux-modem
Roberta F. ColmanRoberta F. Colman
"Adenylosuccinate Lyase: Novel Intersubunit Active Sites". National Institute of Diabetes and Digestive and Kidney Diseases ( ...
https://en.wikipedia.org/wiki/Roberta_F._Colman
NucleotideNucleotide
This step is catalyzed by adenylosuccinate lyase. Inosine monophosphate is converted to guanosine monophosphate by the ... First, GTP hydrolysis fuels the addition of aspartate to IMP by adenylosuccinate synthase, substituting the carbonyl oxygen for ... a nitrogen and forming the intermediate adenylosuccinate. Fumarate is then cleaved off forming adenosine monophosphate. ...
https://en.wikipedia.org/wiki/Nucleotide
Bacillus subtilisBacillus subtilis
Adenylosuccinate lyase deficiency Extremophile Guthrie test YlbH leader.. Euzéby JP (2008). "Bacillus". List of Prokaryotic ...
https://en.wikipedia.org/wiki/Bacillus_subtilis
MorpheeinMorpheein
... of a Mutant Bacillus subtilis Adenylosuccinate Lyase Equivalent to a Mutant Enzyme Found in Human Adenylosuccinate Lyase ... "Evaluation of Types of Interactions in Subunit Association in Bacillus subtilis Adenylosuccinate Lyase". Biochemistry. 47 (9): ...
https://en.wikipedia.org/wiki/Morpheein
Purine metabolismPurine metabolism
GMP back into IMP adenylosuccinate synthase converts IMP to adenylosuccinate adenylosuccinate lyase converts adenylosuccinate ... CAIR + L-Aspartate + ATP → SAICAR + ADP + Pi The eight is catalyzed by adenylosuccinate lyase. SAICAR → AICAR + Fumarate The ...
https://en.wikipedia.org/wiki/Purine_metabolism
GMP synthaseGMP synthase
IMP may also be generated into AMP by adenylosuccinate synthetase and then adenylosuccinate lyase. GMP synthase is also ...
https://en.wikipedia.org/wiki/GMP_synthase
Nucleotide salvageNucleotide salvage
... this is subsequently acted upon by adenylosuccinate synthase and adenylosuccinate lyase, in a two step process, to convert it ... kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum". Biochimica et Biophysica Acta (BBA) - ...
https://en.wikipedia.org/wiki/Nucleotide_salvage
GABPB2GABPB2
... untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency". Am. J. Hum. Genet. 71 (1): 14- ...
https://en.wikipedia.org/wiki/GABPB2
List of diseases (A)List of diseases (A)
... anemia due to Adenylosuccinate lyase deficiency Adie syndrome Adiposis dolorosa, aka Dercum's disease Adolescent benign focal ...
https://en.wikipedia.org/wiki/List_of_diseases_(A)
Angelman syndromeAngelman syndrome
Autism spectrum Cerebral palsy Rett syndrome Mowat-Wilson syndrome Adenylosuccinate lyase deficiency Pitt-Hopkins syndrome ...
https://en.wikipedia.org/wiki/Angelman_syndrome
SAICASAICA
... a molecule whose appearance is characteristic of the disease adenylosuccinate lyase deficiency Saica may refer to: Saica (bug ...
https://en.wikipedia.org/wiki/SAICA
Purine nucleotide cyclePurine nucleotide cycle
Adenylosuccinate + GDP + Pi Finally, adenylosuccinate is cleaved by the enzyme adenylosuccinate lyase to release fumarate and ... to sustain mitochondrial membrane potential during anoxic stress by utilizing fumarate produced by adenylosuccinate lyase as an ... NH4+ The second stage is the formation of adenylosuccinate from IMP and the amino acid aspartate, which is coupled to the ... regenerate the starting material of AMP: Adenylosuccinate → AMP + Fumarate A recent study showed that activation of HIF-1α ...
https://en.wikipedia.org/wiki/Purine_nucleotide_cycle
Causes of autismCauses of autism
... deficiency X-linked creatine transporter defect 6-N-trimethyllysine dioxygenase deficiency Adenylosuccinate lyase deficiency ...
https://en.wikipedia.org/wiki/Causes_of_autism
AdenylosuccinateAdenylosuccinate
... lyase deficiency Purine nucleotide cycle Figures 20.4 and 20.7 in Textbook of Biochemistry, with clinical ... Adenylosuccinate is an intermediate in the interconversion of purine nucleotides inosine monophosphate (IMP) and adenosine ... monophosphate (AMP). The enzyme adenylosuccinate synthase carries out the reaction by the addition of aspartate to IMP and ...
https://en.wikipedia.org/wiki/Adenylosuccinate
Fumarate lyaseFumarate lyase
Adenylosuccinase, EC 4.3.2.2 (adenylosuccinate lyase), which catalyzes the eighth step in the de novo biosynthesis of purines, ... Fumarate lyase is a substrate of the lyase class of enzymes. It been shown to share a short conserved sequence around a ... Aspartate ammonia-lyase, EC 4.3.1.1 (aspartase), which catalyzes the reversible conversion of aspartate to fumarate and ammonia ... Delta-crystallin shares around 90% sequence identity with arginosuccinate lyase, showing that it is an example of a 'hijacked' ...
https://en.wikipedia.org/wiki/Fumarate_lyase
Adenylosuccinate lyaseAdenylosuccinate lyase
... (or adenylosuccinase) is an enzyme that in humans is encoded by the ADSL gene. Adenylosuccinate lyase ... Mutated adenylosuccinate lyase (ASL) causes clinical disease in patients that is referred to as adenylosuccinate lyase ... "The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase ... of a mutant Bacillus subtilis adenylosuccinate lyase equivalent to a mutant enzyme found in human adenylosuccinate lyase ...
https://en.wikipedia.org/wiki/Adenylosuccinate_lyase
Adenylosuccinate lyase deficiencyAdenylosuccinate lyase deficiency
"adenylosuccinate lyase deficiency". Genetics Home Reference. Retrieved 18 December 2016. "Adenylosuccinate lyase deficiency". ... Adenylosuccinate Adenylosuccinate lyase List of genetic disorders Online Mendelian Inheritance in Man (OMIM): 103050 " ... Treatment of adenylosuccinate lyase deficiency can be done via epilepsy management with anticonvulsive drugs. Additionally the ... Adenylosuccinate lyase deficiency is a rare autosomal recessive metabolic disorder characterized by the appearance of ...
https://en.wikipedia.org/wiki/Adenylosuccinate_lyase_deficiency
List of MeSH codes (D08)List of MeSH codes (D08)
... tyrosine phenol-lyase MeSH D08.811.520.232.300 - amidine-lyases MeSH D08.811.520.232.300.200 - adenylosuccinate lyase MeSH ... chondroitin lyases MeSH D08.811.520.241.700.350.500.500 - chondroitin abc lyase MeSH D08.811.520.241.700.512 - heparin lyase ... ammonia-lyases MeSH D08.811.520.232.400.200 - aspartate ammonia-lyase MeSH D08.811.520.232.400.350 - ethanolamine ammonia-lyase ... lyase MeSH D08.811.520.241.300 - hydro-lyases MeSH D08.811.520.241.300.050 - aconitate hydratase MeSH D08.811.520.241.300.050. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
List of EC numbers (EC 4)List of EC numbers (EC 4)
... argininosuccinate lyase EC 4.3.2.2: adenylosuccinate lyase EC 4.3.2.3: ureidoglycolate lyase EC 4.3.2.4: purine imidazole-ring ... pectin lyase EC 4.2.2.11: guluronate-specific alginate lyase EC 4.2.2.12: xanthan lyase EC 4.2.2.13: exo-(1→4)-α-D-glucan lyase ... chondroitin AC lyase EC 4.2.2.6: oligogalacturonide lyase EC 4.2.2.7: heparin lyase EC 4.2.2.8: heparin-sulfate lyase EC 4.2. ... alliin lyase EC 4.4.1.5: lactoylglutathione lyase EC 4.4.1.6: Now included in EC 4.4.1.13, cysteine-S-conjugate β-lyase EC 4.4. ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_4)
List of EC numbers (EC 6)List of EC numbers (EC 6)
... lyase] ligase EC 6.2.1.23: dicarboxylate-CoA ligase EC 6.2.1.24: phytanate-CoA ligase EC 6.2.1.25: benzoate-CoA ligase EC 6.2. ... adenylosuccinate synthase EC 6.3.4.5: argininosuccinate synthase EC 6.3.4.6: urea carboxylase EC 6.3.4.7: ribose-5-phosphate- ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_6)
Ligase - WikipédiaLigase - Wikipédia
... lyase] ligase EC 6.2.1.23 dicarboxylate-CoA ligase EC 6.2.1.24 phytanate-CoA ligase EC 6.2.1.25 benzoate-CoA ligase EC 6.2.1.26 ... EC 6.3.4.3 formate-tetrahydrofolate ligase EC 6.3.4.4 adenylosuccinate synthase EC 6.3.4.5 argininosuccinate synthase EC 6.3. ...
https://fr.m.wikipedia.org/wiki/Ligase
Code System ConceptCode System Concept
... lyase ligase (substance) {130907003 , SNOMED-CT } Citrate--CoA ligase (substance) {130903004 , SNOMED-CT } Cystathionine beta- ... Adenylosuccinate synthase (substance) {37346006 , SNOMED-CT } Alanine-transfer ribonucleic acid ligase (substance) {68429002 , ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=1672007
Code System ConceptCode System Concept
Adenylosuccinate lyase deficiency (disorder) {15285008 , SNOMED-CT } Adult polyglucosan body disease (disorder) {721099001 , ... Deficiency of histidine ammonia-lyase (disorder) {124628005 , SNOMED-CT } Deficiency of hydroxymethylglutaryl-CoA lyase ( ... Argininosuccinate lyase deficiency (disorder) {41013004 , SNOMED-CT } Arterial tortuosity syndrome (disorder) {458432002 , ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=85995004
MedlinePlus: GenesMedlinePlus: Genes
ADSL: adenylosuccinate lyase. *AFF2: ALF transcription elongation factor 2. *AFF4: ALF transcription elongation factor 4 ...
https://medlineplus.gov/genetics/gene
Code System ConceptCode System Concept
Adenylosuccinate lyase (substance). Code System Preferred Concept Name. Adenylosuccinate lyase (substance). Concept Status. ... Enzyme (substance) {90668006 , SNOMED-CT } Substance with lyase mechanism of action (substance) {21533003 , SNOMED-CT } ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=41613000
Adenylosuccinate lyase deficiency: MedlinePlus GeneticsAdenylosuccinate lyase deficiency: MedlinePlus Genetics
Adenylosuccinate lyase deficiency is a neurological disorder that causes brain dysfunction (encephalopathy) leading to ... medlineplus.gov/genetics/condition/adenylosuccinate-lyase-deficiency/ Adenylosuccinate lyase deficiency. ... All forms of adenylosuccinate lyase deficiency are caused by mutations in the ADSL gene. This gene provides instructions for ... Adenylosuccinate lyase deficiency type I (also known as the severe form) is the most common. The signs and symptoms of this ...
https://medlineplus.gov/genetics/condition/adenylosuccinate-lyase-deficiency
Code System ConceptCode System Concept
Adenylosuccinate lyase measurement (procedure). Code System Preferred Concept Name. Adenylosuccinate lyase measurement ( ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=104476008
MedlinePlus: GenesMedlinePlus: Genes
ADSL: adenylosuccinate lyase. *AFF2: ALF transcription elongation factor 2. *AFF4: ALF transcription elongation factor 4 ...
https://medlineplus.gov/genetics/gene/
MedlinePlus: Genetic Conditions: SMedlinePlus: Genetic Conditions: S
Succinylpurinemic autism, see Adenylosuccinate lyase deficiency. *Sucrase-isomaltase deficiency, see Congenital sucrase- ...
https://medlineplus.gov/genetics/condition-s/
Code System ConceptCode System Concept
Adenylosuccinate lyase measurement (procedure) {104476008 , SNOMED-CT } Alanine aminopeptidase measurement (procedure) { ... Histidine ammonia lyase measurement (procedure) {104729003 , SNOMED-CT } Hydroxymethylglutaryl-coenzyme A lyase measurement ( ... Argininosuccinate lyase measurement (procedure) {104534002 , SNOMED-CT } Argininosuccinate synthase measurement (procedure) { ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=122444009
Adenylosuccinate lyase deficiency: MedlinePlus GeneticsAdenylosuccinate lyase deficiency: MedlinePlus Genetics
Adenylosuccinate lyase deficiency is a neurological disorder that causes brain dysfunction (encephalopathy) leading to ... medlineplus.gov/genetics/condition/adenylosuccinate-lyase-deficiency/ Adenylosuccinate lyase deficiency. ... All forms of adenylosuccinate lyase deficiency are caused by mutations in the ADSL gene. This gene provides instructions for ... Adenylosuccinate lyase deficiency type I (also known as the severe form) is the most common. The signs and symptoms of this ...
https://medlineplus.gov/genetics/condition/adenylosuccinate-lyase-deficiency
Adenylosuccinate lyase - WikipediaAdenylosuccinate lyase - Wikipedia
Adenylosuccinate lyase (or adenylosuccinase) is an enzyme that in humans is encoded by the ADSL gene. Adenylosuccinate lyase ... Mutated adenylosuccinate lyase (ASL) causes clinical disease in patients that is referred to as adenylosuccinate lyase ... "The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase ... of a mutant Bacillus subtilis adenylosuccinate lyase equivalent to a mutant enzyme found in human adenylosuccinate lyase ...
https://en.wikipedia.org/wiki/Adenylosuccinate_lyase
Adenylosuccinate Lyase Deficiency | MedLink NeurologyAdenylosuccinate Lyase Deficiency | MedLink Neurology
Adenylosuccinate lyase (ADSL) deficiency is an autosomal recessive defect of purine metabolism, affecting purinosome assembly ... Type I adenylosuccinate lyase deficiency (severe). Most patients reported so far have adenylosuccinate lyase deficiency type I ... Adenylosuccinate lyase deficiency. Adenylosuccinate lyase deficiency, the first enzyme deficiency reported in the DNPS pathway ... Adenylosuccinate lyase deficiency in a Malaysian patient with novel adenylosuccinate lyase gene mutations. J Inherit Metab Dis ...
https://www.medlink.com/articles/adenylosuccinate-lyase-deficiency
Table - Borrelia burgdorferi Sensu Stricto DNA in Field-Collected Haemaphysalis longicornis Ticks, Pennsylvania, United States ...
fliD, flagellin gene; NA, not applicable; oppA2, oligopeptide permease periplasmic A2 gene; purB, adenylosuccinate lyase gene; ...
https://wwwnc.cdc.gov/eid/article/27/2/20-1552-t1
CATH Superfamily 1.10.40.30
FunFam 26: Adenylosuccinate lyase (PurB). * Summary * Alignment * GO * EC * Taxonomy /* https://stackoverflow.com/questions/ ...
http://www.cathdb.info/version/v4_3_0/superfamily/1.10.40.30/funfam/26/alignment
Human Metabolome Database: Showing metabocard for Deoxyribose 1-phosphate (HMDB0001351)Human Metabolome Database: Showing metabocard for Deoxyribose 1-phosphate (HMDB0001351)
Adenylosuccinate lyase deficiency (PMID: 11805243 , PMID: 12535838 , PMID: 15571235 , +2 More Source. Link. ...
https://hmdb.ca/metabolites/HMDB0001351
Pathway specific effects of ADSL deficiency on neurodevelopment | eLifePathway specific effects of ADSL deficiency on neurodevelopment | eLife
Adenylosuccinate Lyase (ADSL) functions in de novo purine biosynthesis (DNPS) and the purine nucleotide cycle. ADSL deficiency ...
https://elifesciences.org/articles/70518v1
HOMD :: SEQF2753HOMD :: SEQF2753
adenylosuccinate lyase. 94. SEQF2753,CP012074.1. AKU68405.1 jb [NA] [AA] 435/144. 137336-137770. DNA-binding protein. ...
https://www.homd.org/genome/explorer?gid=SEQF2753&anno=ncbi
HOMD :: SEQF2867HOMD :: SEQF2867
adenylosuccinate lyase family protein. 77. SEQF2867,CP020440.2. ARC35031.1 jb [NA] [AA] 837/278. 97489-96653. 3-keto-5- ... lactoylglutathione lyase. 149. SEQF2867,CP020440.2. ARC35105.1 jb [NA] [AA] 909/302. 199343-200251. putative selenate ABC ...
https://homd.org/genome/explorer?gid=SEQF2867&anno=ncbi
Table - Borrelia burgdorferi Sensu Stricto DNA in Field-Collected Haemaphysalis longicornis Ticks, Pennsylvania, United States ...
fliD, flagellin gene; NA, not applicable; oppA2, oligopeptide permease periplasmic A2 gene; purB, adenylosuccinate lyase gene; ...
https://wwwnc-origin.cdc.gov/eid/article/27/2/20-1552-t1
HOMD :: SEQF3145HOMD :: SEQF3145
Adenylosuccinate lyase. 6. SEQF3145,RYFV01000011.1. SEQF3145_00006 jb [NA] [AA] 1140/379. 5564-6703. hypothetical protein. ... S-ribosylhomocysteine lyase. 32. SEQF3145,RYFV01000011.1. SEQF3145_00032 jb [NA] [AA] 939/312. 39772-40710. hypothetical ...
https://homd.org/genome/explorer?gid=SEQF3145&anno=prokka
Desempenho, características de carcaça, qualidade de carne, expressão gênica e perfil proteômico do músculo em bovinos f1 Angus...Desempenho, características de carcaça, qualidade de carne, expressão gênica e perfil proteômico do músculo em bovinos f1 Angus...
As proteínas Adenylosuccinate lyase (ADSL) e Alpha-enolase (ENO1), foram observadas apenas em amostras de animais castrados. A ... The proteins Adenylosuccinate lyase (ADSL) e Alpha-enolase (ENO1) were observed only in samples from steers. Castration, ...
https://repositorio.unesp.br/handle/11449/215444
Code System Concept
Adenylosuccinate lyase (substance). Code System Preferred Concept Name. Adenylosuccinate lyase (substance). Concept Status. ... Enzyme (substance) {90668006 , SNOMED-CT } Substance with lyase mechanism of action (substance) {21533003 , SNOMED-CT } ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=41613000
Human HAL(Histidine Ammonia Lyase) ELISA Kit - ELISA KitsHuman HAL(Histidine Ammonia Lyase) ELISA Kit - ELISA Kits
Description: A competitive ELISA for quantitative measurement of Human Adenylosuccinate lyase(ADSL) in samples from blood, ... Human HAL(Histidine Ammonia Lyase) ELISA Kit. Human HAL(Histidine Ammonia Lyase) ELISA Kit. Contact us: [email protected] ... Description: A competitive ELISA for quantitative measurement of Human Adenylosuccinate lyase(ADSL) in samples from blood, ... Description: A competitive ELISA for quantitative measurement of Human Adenylosuccinate lyase(ADSL) in samples from blood, ...
https://myelisakit.com/human-halhistidine-ammonia-lyase-elisa-kit/
Rat CSE(Cystathionine Gamma Lyase) ELISA Kit - The scientist connectRat CSE(Cystathionine Gamma Lyase) ELISA Kit - The scientist connect
Description: A competitive ELISA for quantitative measurement of Rat Adenylosuccinate lyase(ADSL) in samples from blood, plasma ... Description: A competitive ELISA for quantitative measurement of Rat Adenylosuccinate lyase(ADSL) in samples from blood, plasma ... Description: A competitive ELISA for quantitative measurement of Rat Adenylosuccinate lyase(ADSL) in samples from blood, plasma ... Rat CSE(Cystathionine Gamma Lyase) ELISA Kit. Rat CSE(Cystathionine Gamma Lyase) ELISA Kit ...
https://thescientistconnect.com/rat-csecystathionine-gamma-lyase-elisa-kit/
Early Infantile Epileptic Encephalopathy Panel Test - PreventionGeneticsEarly Infantile Epileptic Encephalopathy Panel Test - PreventionGenetics
Adenylosuccinate Lyase Deficiency. AR. 103050. Alternating Hemiplegia of Childhood 2. AD. 614820. ...
https://www.preventiongenetics.com/testInfo?val=Early-Infantile-Epileptic-Encephalopathy-Panel&sel=test
HOMD :: SEQF2546HOMD :: SEQF2546
Adenylosuccinate lyase. 173. SEQF2546,HE798385.1. CCH04164.1 jb [NA] [AA] 141/46. 159683-159823. hypothetical protein. ...
https://ehomd.org/genome/explorer?gid=SEQF2546&anno=ncbi
Fumarate metabolismFumarate metabolism
adenylosuccinate lyase. adenylosuccinate lyase. 4.3.2.2 PF3D7_1354500 PF13_0287. adenylosuccinate synthetase. adenylosuccinate ...
https://mpmp.huji.ac.il/maps/fumarate.html
Armenian-English Medical - Terms starting with 'Ա' - MEDINDEX.AM
ADENYLOSUCCINATE LYASE] 95. ԱԴԻՍՈՆՅԱՆ ՀԻՎԱՆԴՈՒԹՅՈՒՆ [ADDISON`S DISEASE] 46. ԱԴԵՆԻԼՈՍՈՒԿՑԻՆԱՏ-ԼԻԶ [ADENYLOSUCCINATE LYASE] 96. ... ADENYLOSUCCINATE SYNTHETASE] 97. ԱԴԻՖԵՆԻՆ [ADIPHENINE] 48. ԱԴԵՆԻԼՈՍՈՒԿՑԻՆԱՏ-ՍԻՆԹԵՏԱԶ [ADENYLOSUCCINATE SYNTHETASE] 98. ԱԴԻՖԵՆԻՆ ...
http://www.medindex.am/glossary/index.php/list/Armenian-English+Medical/,%D4%B1.xhtml
IMP: Integrative Multi-species Prediction
adenylosuccinate lyase. 0.037. Ints4. integrator complex subunit 4. 0.029. Gnpat. glyceronephosphate O-acyltransferase. 0.029. ...
http://imp.princeton.edu/predictions/process_ortho/rat-context-global/4389/
LIST OF RARE DISEASESLIST OF RARE DISEASES
Adenylosuccinate Lyase Deficiency Adie Syndrome Adrenoleukodystrophy Adult Neuronal Ceroid Lipofuscinosis Adult Onset Stills ...
https://www.nadirhastaliklaragi.org.tr/en/list-of-rare-diseases
Model Search | BioModelsModel Search | BioModels
Adenylosuccinate lyase (4) * Inositol monophosphatase 1 (4) * 3(2),5-bisphosphate nucleotidase (4) ...
https://www.ebi.ac.uk/biomodels/search?query=CHEBI:CHEBI:16566
TransimulationTransimulation
adenylosuccinate lyase isoform a. View. NM_000027. AGA. aspartylglucosaminidase precursor. View. NM_000028. AGL. amylo-1, 6- ...
http://nexus.ibb.waw.pl/Transimulation/default/human_manage?keywords=&order=t_human.f_gene_id
"sequence id","alias","species","description",...
"Adenylosuccinate lyase [Ensembl]. Adenylosuccinate lyase C-terminal [Interproscan].","protein_coding" "CRN97292","nuoB"," ... "pyruvate formate-lyase 4/2-ketobutyrate formate-lyase [Ensembl]. Glycine radical, Pyruvate formate lyase-like [Interproscan ... Adenylosuccinate lyase C-terminus [Interproscan].","protein_coding" "CRO09433","oprM_2","Pseudomonas aeruginosa","Outer ... ","aspartate ammonia-lyase [Ensembl]. Lyase, Fumarase C C-terminus [Interproscan].","protein_coding" "EDJ91600","CGSHi22421_ ...
https://bacteria.sbs.ntu.edu.sg/go/sequences/table/27699
Protein 8500725 in Desulfovibrio vulgaris Miyazaki F
adenylosuccinate lyase (EC 4.3.2.2). 55%. 491.9. Sequence Analysis Tools. View 8500725 at FitnessBrowser ...
https://papers.genomics.lbl.gov/cgi-bin/gapView.cgi?orgs=orgsFit&set=carbon&orgId=FitnessBrowser__Miya&locusId=8500725
Network Portal - Gene BC0324
Adenylosuccinate lyase (NCBI ptt file). 92, 283. BC0631. BC0631. PTS system, trehalose-specific IIBC component (NCBI ptt file) ...
http://networks.systemsbiology.net/bce/gene/BC0324
Network Portal - Gene RSP 2258
Adenylosuccinate lyase (NCBI). 109, 369. RSP_2258. purC. SAICAR synthetase (NCBI). 43, 109. ...
http://networks.systemsbiology.net/rsp/gene/RSP_2258
Model Search | BioModelsModel Search | BioModels
Adenylosuccinate lyase (4) * Inositol monophosphatase 1 (4) * 3(2),5-bisphosphate nucleotidase (4) ...
https://www.ebi.ac.uk/biomodels/search?query=CHEBI:CHEBI:18319
GENEVA: Gene Expression Variation Analysis
Prolyl Hydroxylase Substrate Adenylosuccinate Lyase Is An Oncogenic Driver In Triple Negative Breast Cancer. 1.47. ...
https://genevatool.org/gene_table?gene_name=CCDC12
Associated with Adenylosuccinate lyase defiPurBADSLDeficiency is a rareAdenylosuccinaseBacillusMutantsEnzymeELISA KitCatalysisSuccinyladenosineAdenosine monophosphateSynthaseConvertsDNPSSAICArFumarateBiochemicalSeizuresTissueSevere formManifestationsBiological fluidsSymptomsTypeStudiesSpecific
Associated with Adenylosuccinate lyase defi1
  • Neurologic symptoms are the most common and prominent clinical problems associated with adenylosuccinate lyase deficiency. (medlink.com)
PurB1
  • Ts (BL1504), a transcription elongation factor (NusA) (BL1615), an UDP-galactopyranose mutase (GalE) (BL1644) and the adenylosuccinate lyase (PurB, BL1800). (srcpathway.com)
ADSL4
  • All forms of adenylosuccinate lyase deficiency are caused by mutations in the ADSL gene. (medlineplus.gov)
  • Adenylosuccinate lyase (or adenylosuccinase) is an enzyme that in humans is encoded by the ADSL gene. (wikipedia.org)
  • Adenylosuccinate Lyase (ADSL) functions in de novo purine biosynthesis (DNPS) and the purine nucleotide cycle. (elifesciences.org)
  • As proteínas Adenylosuccinate lyase (ADSL) e Alpha-enolase (ENO1), foram observadas apenas em amostras de animais castrados. (unesp.br)
Deficiency is a rare1
  • Adenylosuccinate lyase deficiency is a rare, autosomal recessive defect of purine metabolism affecting purinosome assembly and reducing metabolite fluxes through both de novo purine synthesis (DNPS) and purine nucleotide recycling pathways. (medlink.com)
Adenylosuccinase1
  • Adenylosuccinase (EC 4.3.2.2 ) (adenylosuccinate lyase) [ 3 ], which catalyzes the eight step in the de novo biosynthesis of purines, the formation of 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide and fumarate from 1-(5- phosphoribosyl)-4-(N-succino-carboxamide). (expasy.org)
Bacillus4
  • Adenylosuccinate lyase in humans and Bacillus subtilis can be competitively inhibited by the substrate analog adenosine phosphonobutyric acid 2'(3'), 5'-diphosphate (APBADP). (wikipedia.org)
  • Gln212, Asn270, and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis. (jefferson.edu)
  • Characterization of a mutant Bacillus subtilis adenylosuccinate lyase equivalent to a mutant enzyme found in human adenylosuccinate lyase deficiency: asparagine 276 plays an important structural role. (jefferson.edu)
  • Effect of a new non-cleavable substrate analog on wild-type and serine mutants in the signature sequence of adenylosuccinate lyase of Bacillus subtilis and Homo sapiens. (jefferson.edu)
Mutants2
  • Biochemical and biophysical analysis of five disease-associated human adenylosuccinate lyase mutants. (medlineplus.gov)
  • Adenylosuccinate lyase mutants can have considerably reduced activity whether the mutation is in or away from the active site. (wikipedia.org)
Enzyme7
  • This gene provides instructions for making an enzyme called adenylosuccinate lyase, which performs two steps in the process that produces purine nucleotides. (medlineplus.gov)
  • Most of the mutations involved in adenylosuccinate lyase deficiency change single protein building blocks (amino acids) in the adenylosuccinate lyase enzyme, which impairs its function. (medlineplus.gov)
  • Adenylosuccinate lyase (ASL) is an enzyme that catalyzes two reactions in the de novo purine biosynthetic pathway. (wikipedia.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Histidine Ammonia Lyase (HAL) in Tissue homogenates, cell lysates and other biological fluids. (myelisakit.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Histidine Ammonia Lyase (HAL) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (myelisakit.com)
  • That enzyme can also catalyzes the formation of fumarate and AMP from adenylosuccinate. (expasy.org)
  • En biochimie , une ligase est une enzyme qui catalyse la jonction de deux molécules (en anglais ligation ) par de nouvelles liaisons covalentes avec hydrolyse concomitante de l' ATP ou d'autres molécules similaires. (wikipedia.org)
ELISA Kit1
  • Description: A sandwich ELISA kit for detection of Histidine Ammonia Lyase from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
Catalysis1
  • It was previously thought that the mechanism of action for adenylosuccinate lyase was a concerted catalysis where the hydrogen on the β-carbon (with respect to the leaving nitrogen) was abstracted by the catalytic base at the same time that the leaving nitrogen was protonated by the catalytic acid for E2 elimination. (wikipedia.org)
Succinyladenosine3
  • Adenylosuccinate lyase converts a molecule called succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and converts succinyladenosine monophosphate (SAMP) to adenosine monophosphate (AMP). (medlineplus.gov)
  • AICAR proceeds through three more reactions before it becomes adenylosuccinate (also called succinyladenosine monophosphate or SAMP), which ASL then splits into adenosine monophosphate (AMP) and fumarate. (wikipedia.org)
  • In addition, we offer CSF sialic acid analysis for disorders of sialic acid metabolism, succinyladenosine as a specific marker for adenylosuccinate lyase deficiency, lactate , pyruvate , glucose for disorders that disrupt cellular energetics, and neopterin as a marker for central nervous system immune system stimulation. (labcorp.com)
Adenosine monophosphate1
  • In the ASL-catalyzed reaction splitting adenylosuccinate into adenosine monophosphate (AMP) and fumarate, the AMP must rotate slightly after the reaction is complete and before fumarate is released in order for both products to fit in the active site. (wikipedia.org)
Synthase1
  • En fait la synthase forme et défait les doubles liaisons d'une protéine. (wikipedia.org)
Converts1
  • Adenylosuccinate lyase converts adenylosuccinate to AMP and fumarate as part of the purine nucleotide cycle. (wikipedia.org)
DNPS2
  • The purinosome is a multienzyme complex of DNPS enzymes (including adenylosuccinate lyase) that cells transiently assemble in their cytosol to address both depletion of and increased demand for purines. (medlink.com)
  • Adenylosuccinate lyase deficiency can be diagnosed by detection of elevated metabolites along the DNPS pathway (succinylpurines) in body fluids. (medlink.com)
SAICAr2
  • Studies suggest that the amount of SAICAr relative to S-Ado reflects the severity of adenylosuccinate lyase deficiency. (medlineplus.gov)
  • ASL cleaves adenylosuccinate into AMP and fumarate, and cleaves SAICAR into AICAR and fumarate. (wikipedia.org)
Fumarate2
  • Aspartate ammonia-lyase (EC 4.3.1.1 ) (aspartase), which catalyzes the reversible conversion of aspartate to fumarate and ammonia. (expasy.org)
  • Arginosuccinase (EC 4.3.2.1 ) (argininosuccinate lyase), which catalyzes the formation of arginine and fumarate from argininosuccinate, the last step in the biosynthesis of arginine. (expasy.org)
Biochemical1
  • Detection of succinylpurines in body fluids by high-performance liquid chromatography or liquid chromatography-tandem mass spectrometry is the preferred biochemical test for adenylosuccinate lyase deficiency. (medlink.com)
Seizures1
  • Adenylosuccinate lyase deficiency is a neurological disorder that causes brain dysfunction (encephalopathy) leading to delayed development of mental and movement abilities (psychomotor delay), autistic behaviors that affect communication and social interaction, and seizures. (medlineplus.gov)
Tissue1
  • damage to brain tissue caused by one or both of these substances likely underlies the neurological problems that occur in adenylosuccinate lyase deficiency. (medlineplus.gov)
Severe form2
  • Adenylosuccinate lyase deficiency type I (also known as the severe form) is the most common. (medlineplus.gov)
  • Clinically, adenylosuccinate lyase deficiency is generally categorized into three phenotypes: a fatal neonatal form, a severe form (type I), and a milder form (type II). (medlink.com)
Manifestations2
  • The clinical presentation of adenylosuccinate lyase deficiency varies greatly with respect to age of onset, clinical manifestations, and rate of disease progression. (medlink.com)
  • Corinna's research uses C. elegans with a reduced adenylosuccinate lyase activity to study neurobehavioral manifestations associated with the human disease adenylosuccinate lyase deficiency (ASLD). (psu.edu)
Biological fluids1
  • Description: A sandwich ELISA for quantitative measurement of Human L Phenylalanine ammonia lyase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (myelisakit.com)
Symptoms3
  • Adenylosuccinate lyase deficiency is classified into three forms based on the severity of the signs and symptoms. (medlineplus.gov)
  • Point mutations in adenylosuccinate that cause lowered enzymatic activity cause clinical symptoms that mark the condition adenylosuccinate lyase deficiency. (wikipedia.org)
  • Patients with adenylosuccinate lyase deficiency can present with nonspecific symptoms, such as developmental delay, autism spectrum disorder, or epilepsy, including infantile spasms. (medlink.com)
Type1
  • In individuals with adenylosuccinate lyase deficiency type II (also known as the moderate or mild form), development is typically normal for the first few years of life but then slows. (medlineplus.gov)
Studies1
  • APBADP is a competitive inhibitor for both of the reactions catalyzed by adenylosuccinate lyase, and kinetic studies with APBADP show that the substrates for both reactions use the same active site. (wikipedia.org)
Specific1
  • No specific FDA-approved treatment is available for adenylosuccinate lyase deficiency. (medlink.com)