An enzyme that, in the course of purine ribonucleotide biosynthesis, catalyzes the conversion of 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole to 5'-phosphoribosyl-4-carboxamide-5-aminoimidazole and the conversion of adenylosuccinic acid to AMP. EC 4.3.2.2.
A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyzes the synthesis of adenylosuccinate from GTP; IMP; and aspartate with the formation of orthophosphate and GDP. EC 6.3.4.4.
A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (Enzyme Nomenclature, 1992) EC 4.
An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. Compounded with orotic acid, it is used to treat liver diseases.
A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
Nucleotides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)
Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
A rod-shaped bacterium surrounded by a sheath-like structure which protrudes balloon-like beyond the ends of the cell. It is thermophilic, with growth occurring at temperatures as high as 90 degrees C. It is isolated from geothermally heated marine sediments or hot springs. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
A species of gram-positive bacteria that is a common soil and water saprophyte.
A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The rate dynamics in chemical or physical systems.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A genus of rod-shaped, almost rectangular ARCHAEA, in the family THERMOPROTEACEAE. Organisms are facultatively aerobic or strictly anaerobic, grow on various organic substrates, and are found in continental solfataras.
A family of THERMOPROTEALES consisting of variable length rigid rods without septa. They grow either chemolithoautotrophically or by sulfur respiration. The four genera are: PYROBACULUM; THERMOPROTEUS; Caldivirga; and Thermocladium. (From Bergey's Manual of Systematic Bacteriology, 2d ed)
Rare autosomal recessive disorder of the urea cycle which leads to the accumulation of argininosuccinic acid in body fluids and severe HYPERAMMONEMIA. Clinical features of the neonatal onset of the disorder include poor feeding, vomiting, lethargy, seizures, tachypnea, coma, and death. Later onset results in milder set of clinical features including vomiting, failure to thrive, irritability, behavioral problems, or psychomotor retardation. Mutations in the ARGININOSUCCINATE LYASE gene cause the disorder.
Affection; in psychiatry commonly refers to pleasure, particularly as it applies to gratifying experiences between individuals.
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Organized activities related to the storage, location, search, and retrieval of information.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Sequential operating programs and data which instruct the functioning of a digital computer.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.
Production of drugs or biologicals which are unlikely to be manufactured by private industry unless special incentives are provided by others.
The deliberate and methodical practice of finding new applications for existing drugs.
Prospective patient listings for appointments or treatments.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
A disease characterized by the progressive invasion of SMOOTH MUSCLE CELLS into the LYMPHATIC VESSELS, and the BLOOD VESSELS. The majority of the cases occur in the LUNGS of women of child-bearing age, eventually blocking the flow of air, blood, and lymph. The common symptom is shortness of breath (DYSPNEA).
A condition characterized by the formation of CALCULI and concretions in the hollow organs or ducts of the body. They occur most often in the gallbladder, kidney, and lower urinary tract.

Capillary electrophoresis for detection of inherited disorders of purine and pyrimidine metabolism. (1/51)

BACKGROUND: Measurement of purine and pyrimidine metabolites presents complex problems for separations currently performed by HPLC and thin-layer chromatography in clinical practice. We developed a novel capillary electrophoresis method for this purpose. METHODS: Separations were performed in 60 mmol/L borate-2-amino-2-methyl-1-propanol-80 mmol/L sodium dodecyl sulfate (pH 9.6) at 35 degrees C. RESULTS: The conditions reported allowed separation of all diagnostic metabolites from major urinary constituents in an analysis time of 3 min and with a separation efficiency of 220 000 theoretical plates/m. The clinically important metabolites were detectable at concentrations of 0.85-4.28 micromol/L. The method was linear over the range 5-500 micromol/L (r >0.99). The within-run and intra- and interday imprecision (CV) was <5%. Characteristic abnormalities were detected in the electropherograms of urine samples from patients with purine and pyrimidine enzyme deficiencies. We provide the electrophoretic and spectral characteristics of many intermediates in purine and pyrimidine metabolism and describe common artifacts from medication and ultraviolet-absorbing compounds. CONCLUSION: Capillary electrophoresis is a valuable screening tool in the detection of inborn errors of purine and pyrimidine metabolism.  (+info)

The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway. (2/51)

BACKGROUND: Adenylosuccinate lyase is an enzyme that plays a critical role in both cellular replication and metabolism via its action in the de novo purine biosynthetic pathway. Adenylosuccinate lyase is the only enzyme in this pathway to catalyze two separate reactions, enabling it to participate in the addition of a nitrogen at two different positions in adenosine monophosphate. Both reactions catalyzed by adenylosuccinate lyase involve the beta-elimination of fumarate. Enzymes that catalyze this type of reaction belong to a superfamily, the members of which are homotetramers. Because adenylosuccinate lyase plays an integral part in maintaining proper cellular metabolism, mutations in the human enzyme can have severe clinical consequences, including mental retardation with autistic features. RESULTS: The 1.8 A crystal structure of adenylosuccinate lyase from Thermotoga maritima has been determined by multiwavelength anomalous dispersion using the selenomethionine-substituted enzyme. The fold of the monomer is reminiscent of other members of the beta-elimination superfamily. However, its active tetrameric form exhibits striking differences in active-site architecture and cleft size. CONCLUSIONS: This first structure of an adenylosuccinate lyase reveals that, along with the catalytic base (His141) and the catalytic acid (His68), Gln212 and Asn270 might play a vital role in catalysis by properly orienting the succinyl moiety of the substrates. We propose a model for the dual activity of adenylosuccinate lyase: a single 180 degrees bond rotation must occur in the substrate between the first and second enzymatic reactions. Modeling of the pathogenic human S413P mutation indicates that the mutation destabilizes the enzyme by disrupting the C-terminal extension.  (+info)

Succinylpurinemic autism: increased sensitivity of defective adenylosuccinate lyase towards 4-hydroxy-2-nonenal. (3/51)

We studied the effect of trans-4-hydroxy-2-nonenal on the wild-type human adenylosuccinate lyase and on the enzyme from a patient compound-heterozygous for two missense mutations (P75A/D397Y; McKusick 103050.0003/103050.0004). Both the enzymes were inhibited by 10-50 microM trans-4-hydroxy-2-nonenal in a concentration-dependent manner by means of a mixed-type co-operative mechanism. A significantly stronger inhibition was noticed in the presence of the defective enzyme. Nonanal and trans-2,3-nonenal inhibited the enzymes to a less extent and at about 10-times higher concentrations. Hydroxylamine reversed the inhibition by trans-4-hydroxy-2-nonenal, trans-2,3-nonenal or nonanal in the case of the wild-type enzyme, but it was ineffective to reverse the inhibition by trans-4-hydroxy-2-nonenal on the defective enzyme. Dithiothreitol slightly decreased the inhibition exerted by trans-4-hydroxy-2-nonenal on both the wild-type and the defective adenylosuccinate lyase, while it did not produce practically any change in the presence of trans-2,3-nonenal or nonanal.  (+info)

Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure and molecular basis for ADSL deficiency in six patients. (4/51)

Adenylosuccinate lyase (ADSL) is a bifunctional enzyme acting in de novo purine synthesis and purine nucleotide recycling. ADSL deficiency is a selectively neuronopathic disorder with psychomotor retardation and epilepsy as leading traits. Both dephosphorylated enzyme substrates, succinylaminoimidazole-carboxamide riboside (SAICAr) and succinyladenosine (S-Ado), accumulate in the cerebrospinal fluid (CSF) of affected individuals with S-Ado/SAICAr concentration ratios proportional to the phenotype severity. We studied the disorder at various levels in a group of six patients with ADSL deficiency. We identified the complete ADSL cDNA and its alternatively spliced isoform resulting from exon 12 skipping. Both mRNA isoforms were expressed in all the tissues studied with the non-spliced form 10-fold more abundant. Both cDNAs were expressed in Escherichia coli and functionally characterized at the protein level. The results showed only the unspliced ADSL to be active. The gene consists of 13 exons spanning 23 kb. The promotor region shows typical features of the housekeeping gene. Eight mutations were identified in a group of six patients. The expression studies of the mutant proteins carried out in an attempt to study genotype-phenotype correlation showed that the level of residual enzyme activity correlates with the severity of the clinical phenotype. All the mutant enzymes studied in vitro displayed a proportional decrease in activity against both of their substrates. However, this was not concordant with strikingly different concentration ratios in the CSF of individual patients. This suggests either different in vivo enzyme activities against each of the substrates and/or their different turnover across the CSF-blood barrier, which may be decisive in determining disease severity.  (+info)

Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency. (5/51)

Adenylosuccinate lyase (ADSL) deficiency (MIM 103050) is an autosomal recessive inborn error of purine synthesis characterized by the accumulation in body fluids of succinylaminoimidazolecarboxamide (SAICA) riboside and succinyladenosine (S-Ado), the dephosphorylated derivatives of the two substrates of the enzyme. Because ADSL-deficient patients display widely variable degrees of psychomotor retardation, we have expressed eight mutated ADSL enzymes as thioredoxin fusions and compared their properties with the clinical and biochemical characteristics of 10 patients. Three expressed mutated ADSL enzymes (M26L, R426H and T450S) were thermolabile, four (A2V, R141W, R303C and S395R) were thermostable and one (del206-218), was inactive. Thermolabile mutations decreased activities with SAICA ribotide (SAICAR) and adenylosuccinate (S-AMP) in parallel, or more with SAICAR than with S-AMP. Patients homozygous for one of these mutations, R426H, displayed similarly decreased ADSL activities in their fibroblasts, S-Ado:SAICA riboside ratios of approximately 1 in their cerebrospinal fluid and were profoundly retarded. With the exception of A2V, thermostable mutations decreased activity with S-AMP to a much more marked extent than with SAICAR. Two unrelated patients homozygous for one of the thermostable mutations, R303C, also displayed a much more marked decrease in the activity of fibroblast ADSL with S-AMP than with SAICAR, had S-Ado:SAICA riboside ratios between 3 and 4 in their cerebrospinal fluid and were mildly retarded. These results suggest that, in some cases, the genetic lesion of ADSL determines the ratio of its activities with S-AMP versus SAICAR, which in turn defines the S-Ado:SAICA riboside ratio and the patients' mental status.  (+info)

Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency. (6/51)

Adenylosuccinate lyase (ADSL; also called "adenylosuccinase") catalyzes two steps in the synthesis of purine nucleotides: (1) the conversion of succinylaminoimidazolecarboxamide ribotide into aminoimidazolecarboxamide ribotide and (2) the conversion of adenylosuccinate into adenosine monophosphate. ADSL deficiency, a recessively inherited disorder, causes variable-but most often severe-mental retardation, frequently accompanied by epilepsy and/or autism. It is characterized by the accumulation, in body fluids, of succinylaminoimidazolecarboxamide riboside and succinyladenosine, the dephosphorylated derivatives of the two substrates of the enzyme. Analysis of the ADSL gene of three unrelated patients with ADSL deficiency, in whom one of the ADSL alleles displayed a normal coding sequence, revealed a -49T-->C mutation in the 5' untranslated region of this allele. Measurements of the amount of mRNA transcribed from the latter allele showed that it was reduced to approximately 33% of that transcribed from the alleles mutated in their coding sequence. Further investigations showed that the -49T-->C mutation provokes a reduction to 25% of wild-type control of promoter function, as evaluated by luciferase activity and mRNA level in transfection experiments. The mutation also affects the binding of nuclear respiratory factor 2 (NRF-2), a known activator of transcription, as assessed by gel-shift studies. Our findings indicate that a mutation of a regulatory region of the ADSL gene might be an unusually frequent cause of ADSL deficiency, and they suggest a role for NRF-2 in the gene regulation of the purine biosynthetic pathway.  (+info)

Splicing graphs and EST assembly problem. (7/51)

MOTIVATION: The traditional approach to annotate alternative splicing is to investigate every splicing variant of the gene in a case-by-case fashion. This approach, while useful, has some serious shortcomings. Recent studies indicate that alternative splicing is more frequent than previously thought and some genes may produce tens of thousands of different transcripts. A list of alternatively spliced variants for such genes would be difficult to build and hard to analyse. Moreover, such a list does not show the relationships between different transcripts and does not show the overall structure of all transcripts. A better approach would be to represent all splicing variants for a given gene in a way that captures the relationships between different splicing variants. RESULTS: We introduce the notion of the splicing graph that is a natural and convenient representation of all splicing variants. The key difference with the existing approaches is that we abandon the linear (sequence) representation of each transcript and replace it with a graph representation where each transcript corresponds to a path in the graph. We further design an algorithm to assemble EST reads into the splicing graph rather than assembling them into each splicing variant in a case-by-case fashion.  (+info)

The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase deficiencies. (8/51)

Adenylosuccinate lyase is a homotetramer that catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide (SAICAR). Several point mutations in the gene encoding the enzyme have been implicated in human disease. Bacillus subtilis adenylosuccinate lyase was used as a model system in which mutations were constructed corresponding to those mutations associated with severe human adenylosuccinate lyase deficiency. Site-directed mutagenesis was utilized to construct amino acid substitutions in B. subtilis adenylosuccinate lyase; Met(10), Ile(123), and Thr(367) were replaced by Leu, Trp, and Arg, respectively, and the altered enzymes were expressed in Escherichia coli. These purified enzymes containing amino acid substitutions were found to have substantial catalytic activity and exhibit relatively small changes in their kinetic parameters. The major deviations from the wild-type-like behavior were observed upon biophysical characterization. All of these enzymes with amino acid replacements are associated with marked thermal instability. I123W adenylosuccinate lyase exhibits notable changes in the circular dichroism spectra, and a native gel electrophoresis pattern indicative of some protein aggregation. T367R also exhibits alterations at the quarternary level, as reflected in native gel electrophoresis. Experimental results, combined with homology modeling, suggest that the altered enzymes are primarily structurally impaired. The enzyme instability was found to be lessened by subunit complementation with the wild-type enzyme, under mild conditions; these studies may have implications for the in vivo behavior of adenylosuccinate lyase in heterozygous patients. Residues Met(10), Ile(123), and Thr(367) appear to be located in regions of the enzyme important for maintaining the structural integrity required for a stable, functional enzyme.  (+info)

2VD6: Human adenylosuccinate lyase in complex with its substrate N6-(1,2- Dicarboxyethyl)-AMP, and its products AMP and fumarate.
Get natural cures for Adenylosuccinate lyase deficiency that can make a difference in your life or the life of someone you love with alternative treatments.
Adenylosuccinate lyase is an enzyme of fumarase superfamily that participates in the purine biosynthetic pathway, catalysing the nonhydrolytic cleavage of succinyl groups from SAICA ribotide and adenylosuccinate. Enzyme defects are associated with a
Definition of adenylosuccinate lyase. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
1F1O: The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.
Adenylosuccinate Lyase; Catalyzes Two Steps In The de Novo Purine Nucleotide Biosynthetic Pathway; Expression Is Repressed By Adenine And Activated By Bas1p And Pho2p; Mutations In Human Ortholog ADSL Cause Adenylosuccinase Deficiency
Adenylosuccinate Lyase; Catalyzes Two Steps In The de Novo Purine Nucleotide Biosynthetic Pathway; Expression Is Repressed By Adenine And Activated By Bas1p And Pho2p; Mutations In Human Ortholog ADSL Cause Adenylosuccinase Deficiency
Adenylosuccinate lyase (ASL) catalyzes 2 reactions in the de novo synthesis of purine nucleotides. In humans, point mutations of this enzyme are associated with mental retardation, autism, and muscle wasting. The sequence of B. subtilis ASL is 27% identical and 17% similar to the human enzyme. We have cloned, expressed, and purified B. subtilis ASL; the crystal structure of a 73% homologous bacterial enzyme is known (PDB #lc3u). We separately mutated 2 amino acids in the B. subtilis ASL (M10L & N276C) equivalent to the mutations identified in human ASL deficiency (M26L & R303C). The purified M10L and N276C possess specific activities of 0.86 and 0.38 units/mg, respectively, as compared to 1.56 units/mg for wild type (WT) enzyme. Both enzymes are similar to WT in conformation and oligomeric state as indicated by circular dichroism and light scattering. The Km for adenylosuccinate (SAMP) is not appreciably different between M1OL (5.6 uM) and WT (4.9 uM); and the pH dependence of Vmax is also ...
Banerjee, Sanchari and Agrawal, Monika J and Mishra, Diptimayee and Sharan, Siddharth and Balaram, Hemalatha and Savithri, Handanhal S and Murthy, Mathur RN (2014) Structural and kinetic studies on adenylosuccinate lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme. In: FEBS JOURNAL, 281 (6). pp. 1642-1658. Chittori, Sagar and Simanshu, Dhirendra Kumar and Banerjee, Sanchari and Murthy, Ambika Mosale Venkatesh and Mathivanan, Subashini and Savithri, Handanahal Subbarao and Murthy, Mathur Ramabhadrashastry Narasimha (2013) Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): Insights from kinetic and crystallographic studies. In: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834 (10). pp. 2036-2044. ...
Looking for online definition of SAICAR or what SAICAR stands for? SAICAR is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms
This is a simplified example ADSL dataset for an AKI trial. It is anticipated that, for many studies, other variables of interest would be included. The dataset includes information needed to derive the studys composite primary endpoint. Not all ADSL variables are shown; this example focuses on specific variables useful for AKI analysis. See the ADaMIG for required ADSL variables. ...
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On 16 April 2014, the ACCC decided to extend the existing the final access determinations (FADs) for the declared fixed line services (LCS, WLR, LSS, ULLS, PSTN OA (FOAS as of 1 August 2014), PSTN TA (FTAS as of August 1 2014) and the wholesale ADSL service. The ACCC is extending these FADs as it will not be in a position to make the new fixed line services and the wholesale ADSL service FADs prior to their expiration. ...
Our road infrastructure has an upto 70mph limit.. My rather old landrover will only do about 50mph, so perhaps I should only pay 71% of the Road Tax for my vehicle.. There are several national speed limit roads near where I live. I defy anyone to drive down them at 60mph, even though that is the therectical limit.. When I bought my latest vehicle, I checked the official fuel consumption figures. Apparently I can get upto 52mpg. Like that will ever happen! Even if I drive like a nun.. These days, most ISPs package their products with download limits, rather than speed.. The upto speed is only the maximum of the technology they are using. They could say they use ADSL, ADSL2 & let the customer work out what speed they are likely to get.. Anybody know who to contact to get my Road Tax refunded?. ...
This gene encodes a member of the adenylosuccinate synthase family of proteins. The encoded muscle-specific enzyme plays a role in the purine nucleotide cycle by catalyzing the first step in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP). Mutations in this gene may cause adolescent onset distal myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016 ...
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family (333 aa ...
K. Eaazhisai, R. Jayalakshmi, P. Gayathri, R. P. Anand, K. Sumathy, H. Balaram and M. R. N. Murthy, Crystal structure of fully-ligated adenylosuccinate synthetase from Plasmodium falciparum, Journal of Molecular Biology 335, 1251 - 1264 (2004 ...
K. Eaazhisai, R. Jayalakshmi, P. Gayathri, R. P. Anand, K. Sumathy, H. Balaram and M. R. N. Murthy, Crystal structure of fully-ligated adenylosuccinate synthetase from Plasmodium falciparum, Journal of Molecular Biology 335, 1251 - 1264 (2004 ...
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Configure modem ISDNADSL and cable for better performance Repair system setup and protect regeditProtect Internet Explorer Clear cookie cache history and password 1Configure modem ISDN ADSL and Cable for better performance 2Set
Say if we need a thicker cable to transmit signals better, then one could just add additional strands no? And what if these strands just happened to...
Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.
Wholesale supplier estimates the reported service issue will be investigated on or before 27/06/2018 7:00PM. Please ensure suitable access to main distribution frame or the network boundary point is available. Usually when the technician is arranged as a commitment, they dont need to have access inside the premises. However we may need to wait without having further changes or troubleshooting until the technician visit is completed ...
On June my PC was invaded by a virus (probably Rombertik or similar). I could not eliminate it.On August I moved of house and address. I hired a new ADSL
The MaxTester 635 offers a fast, easy-to-use and cost-effective solution for installation and activation of multiplay services over copper/ADSL2+/VDSL2 and Ethernet.
Hi all, Im currently having problems with ny network at home. Im currently using an old (about 5 years old) Belkin router, ADSL 2+ which is connected...
While the package does not explicitly say that up to speeds are to be outlawed, a statement by Neelie Kroes suggests that this may be the intent no more up to 30 Megabit deals that in practice just offer 3. The UK already has broadband speeds code of practice but it is voluntary and this new set of rules are defining rights enshrined in law. So what actual data speeds really means is important, but for now that is anyones guess, the existing UK code of practice may be enough, but be compulsory rather than voluntary. Certainly the UK moving to a gaining provider led system for migrations in 2015 ticks the switching box.. We know many who will applaud the end to up to speeds since it will expose real performance of ADSL and VDSL2 based services, but it will also make life harder for the various fixed speed connection services such as cable and FTTH/FTTP/FTTB, since contention and shared access on the backhaul networks is the sole reason that mortals can afford broadband connections at ...
Comprar un Suplemento en cápsulas de L Arginina pura y concentrada para entrenar barato L-arginine Fuel 1500mg con envío rápido para mejorar energía.
45년 이상 동안 SSI는 세계 전역의 다이버, 다이빙 강사, 다이브 센터 및 리조트에 교육, 스쿠버 다이빙 인증과 교육 재료들을 제공해왔습니다.
TY - JOUR. T1 - Role of purine synthesis on renal function. T2 - effect of adenylosuccinate synthetase inhibition.. AU - Lien, Y. H.. AU - Lai, L. W.. AU - Cheung, C.. AU - Patterson, D.. AU - Chan, L.. PY - 1991. Y1 - 1991. UR - http://www.scopus.com/inward/record.url?scp=0026298144&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0026298144&partnerID=8YFLogxK. M3 - Article. C2 - 1807901. AN - SCOPUS:0026298144. VL - 95. SP - 112. EP - 119. JO - Contributions to Nephrology. JF - Contributions to Nephrology. SN - 0302-5144. ER - ...
17α-hydroxylase/17,20-lyase deficiency is caused by mutations in the CYP17A1 gene. The protein produced from this gene is involved in the formation of steroid hormones. This group of hormones includes sex hormones such as testosterone and estrogen, which are needed for normal sexual development and reproduction; mineralocorticoids, which help regulate the bodys salt and water balance; and glucocorticoids, which are involved in maintaining blood sugar levels and regulating the bodys response to stress.. Steroid hormones are produced through a series of chemical reactions. The CYP17A1 enzyme performs two important reactions in this process. The enzyme has 17 alpha(α)-hydroxylase activity, which is important for production of glucocorticoids and sex hormones. CYP17A1 also has 17,20-lyase activity, which is integral to the production of sex hormones.. 17α-hydroxylase/17,20-lyase deficiency results from a shortage (deficiency) of both enzyme activities. The amount of remaining enzyme activity ...
ID D1YV79_METPS Unreviewed; 337 AA. AC D1YV79; DT 09-FEB-2010, integrated into UniProtKB/TrEMBL. DT 09-FEB-2010, sequence version 1. DT 11-DEC-2019, entry version 67. DE RecName: Full=Adenylosuccinate synthetase {ECO:0000256,HAMAP-Rule:MF_00011, ECO:0000256,RuleBase:RU000520}; DE Short=AMPSase {ECO:0000256,HAMAP-Rule:MF_00011}; DE Short=AdSS {ECO:0000256,HAMAP-Rule:MF_00011}; DE EC=6.3.4.4 {ECO:0000256,HAMAP-Rule:MF_00011, ECO:0000256,RuleBase:RU000520}; DE AltName: Full=IMP--aspartate ligase {ECO:0000256,HAMAP-Rule:MF_00011}; GN Name=purA {ECO:0000256,HAMAP-Rule:MF_00011, GN ECO:0000313,EMBL:BAI60351.1}; GN OrderedLocusNames=MCP_0279 {ECO:0000313,EMBL:BAI60351.1}; OS Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / OS SANAE). OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia; OC Methanocellales; Methanocellaceae; Methanocella. OX NCBI_TaxID=304371 {ECO:0000313,EMBL:BAI60351.1, ECO:0000313,Proteomes:UP000001882}; RN [1] {ECO:0000313,Proteomes:UP000001882} RP ...
SWISS-MODEL Repository entry for A8Q0E3 (PURA_MALGO), Adenylosuccinate synthetase. Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)(Dandruff-associated fungus)
Rabbit polyclonal antibody raised against a full-length human ASL protein. ASL (NP_000039.2, 1 a.a. ~ 464 a.a) full-length human protein. (H00000435-D01P) - Products - Abnova
Which should give you the revision number of your modem. If your modem is revision 0 or 2 you will need the KQD6_3.012 file. If your modem is revision 4, then you will require the ZZZL_3.012 file. Both of these files can be located in this tarball here. You will, later, need the firmware-extractor too, which can be found here. Finally you should check this page to find out the VPI/VCI numbers for your country or ISP. Now you have everything, save a copy of this guide too (in text helps), and copy everything to a USB flash drive, floppy disk (if it fits), or a USB external hard drive, so you can use them while offline. NOTE: Unzip isnt supported in a basic Arch Linux installation, you should unzip any .zip files using another computer or operating system first. ...
An improved discrete multi-tone transmission scheme is describe that contemplates encoding digital data and modulating the encoded data onto a discrete multi-tone signal having a total bandwidth of at least 1.6 MHz. The modulation system is capable of dynamically updating the subcarriers used and the amount of data transmitted on each subcarrier during transmission in order to accommodate real time changes in the line quality over particular subcarriers. In one preferred embodiment of the invention the multi-tone encoding and modulation is done in substantial compliance with the ATIS North American Asymmetric Digital Subscriber Lines standard although a total of 512 subchannels each having a bandwidth of approximately 4.3125 kHz are used. In this system, the subchannels that occur at frequencies above those set forth in the standard are treated similarly to those within the standard range in terms of subcarrier selection criteria. This embodiment contemplates the use of a discrete multi-tone signal
RSAWEB Connecting Tomorrow.. In this increasingly digital age it is imperative that businesses and individuals harness the power of the Internet in order to stay ahead. RSAWEB makes the Internet work for you by connecting people, places, platforms and applications to make your life easier, faster and ultimately better.. RSAWEB offers the best in connectivity and hosting products for both businesses and individuals. Whether it is ADSL , Fibre, Mobile Data or Cloud solutions that you are looking for, RSAWEB has a solution to suit your needs and budget.. Since 2001, RSAWEB has grown rapidly, gaining extensive industry experience and expertise while continuously improving their products and pushing boundaries. With great commitment to customer service excellence and in-depth technical understanding, RSAWEB retains partnerships with some of SAs leading companies.. We bridge the gap between IT innovation and everyday life - and the RSAWEB team takes pride in doing this every day. - RSAWEB Director, ...
I want to make the leap to linux (specifically Redhat 7.2) but Im pretty sure my modem isnt gonna work with it. Can anyone recommend a good modem that I should get? Is an external modem a good bet? Also what about cable/adsl modems, as I think pretty soon in the future Im going to go for broadband, what are peoples experience with getting these to work? thanks a lot, hush
Alle 16:39 di sabato 8 dicembre 2007, Francesco Groccia ha scritto: , Leonardo Canducci ,[email protected], writes: , , Il giorno sab, 08/12/2007 alle 12.00 +0100, Francesco Groccia ha , , , , scritto: , , , se ti può essere utile, ho preso un router adsl a meno di 25 , , , euro, firewall integrato, 4 porte ethernet, configurabile via , , , browser, supporta ADSL2 e 2+ (quindi anche le linee veloci di , , , ultima generazione) , , , , marca? modello? , , Sweex annex fiko, ma a meno di 44€ non lho trovato. a 25 dove? -- Franco Alle prossime elezioni voterò Bakunin, che purtroppo non è in lista. Luciano Bianciardi, 8 marzo 1971 ...
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I couldnt get away from Sky soon enough. Was with them on ADSL for a while, and had constant problems with the crappy router they provided. There was a bug in its firmware that meant that connected devices were never displayed properly. I either got a list of the same device connected repeatedly, or, an incomprehensible list of devices in what looked like wingdings. I complained to Sky, who acknowledged that they were aware of the problem, and that Dlink had released a firmware update several years earlier. Sky refused to release that for their customers and also refused to give me my username and password, to allow me to use a decent router.. When fibre became available Sky offered up to 40Mbps, BT offered up to 70Mbps for the same price. We get well over the 40 offered by Sky, usually hitting around 60.. The process of leaving was painful, with quite probably the rudest call centre handler in history, who was shouting and refusing to listen, intent on going through her script of bribes to ...
Well, note to self: dont try doing tech support when late at night. That ADSL modem router WiFi firewall box thingy that apparently wouldnt work anymore? It does work. It did come up on its default address of 192.168.1.1, but there was a reason Id failed to be able to connect to it. Now, Im…
F-, fhuA2::IS2, lacY1, tsx-70, glnX44(AS), gal-6, λ-, purB51, hemA30, trpC45, pabB5, his-68, rfbC1, tyrA2, galP63, rpsL125(strR), malT1(λR), xyl-7, mtlA2, thiE1, pyr-65 ...
Discover Lifes page about the biology, natural history, ecology, identification and distribution of Augochlora pura - -- Discover Life
The effect of 3-mercaptopicolinate, an inhibitor of phosphoenolpyruvate carboxykinase [GTP:oxaloacetate carboxy-lyase (transphosphorylating), EC 4.1.1.32], was tested on NH3 formation via the purine nucleotide cycle and glutamate dehydrogenase (EC 1.4.1.2). NH3 excretion in rats increased 70-fold after 48 h of NH4Cl feeding, from 12.2 +/- 4.5 to 862 +/- 190 mumol/mg of creatinine. At 4 h after a single intraperitoneal injection of 3-mercaptopicolinate into NH4Cl-fed rats, NH3 excretion was inhibited by 93%. Kidneys of NH4Cl-fed plus 3-mercaptopicolinate-treated rats, compared with those of NH4Cl-fed rats, showed a 3.5-fold increase in the content of IMP, 5-fold increase in adenylosuccinate, 4-fold increase in aspartate, and a 30% increase in AMP. 3-Mercaptopicolinate completely inhibited NH3 and glucose formation from glutamate in tubules from acidotic rats and NH3 formation from aspartate in kidney perfusion experiments. When transamination in tubules was prevented by ...
Easy Driver Pro performs a complete scan of your all of the devices in or attached to your computer. All rights reserved. It can determine which D-Link DSL-200 Modem Drivers For Windows 8 are either missing, corrupt, or have become obsolete. If you have found our site useful, we will appreciate it if you tell your friends about us in social networks. D-Link DSL-200 USB ADSL Modem(WAN):The D-Link DSL-200 is an external plug and play ADSL USB modem The DSL-200 allows a Windows based PC to connect via Glite or Gdmt ADSL to Easy Driver Pro free scan will find all the outdated drivers on your PC. Auto-Tune Evo VST 6.0.9.2 Corrects vocals or solo instruments. http://atlantecsoftware.com/dslw200-modem/d-link-dsl-200-drivers-download.html Easy Driver Pro will scan your computer for missing, corrupt, and outdated Drivers. Learn more or ✐ Close Software Free Download , Soft32.com Home Windows Mac Mobile Blog Search You can skip this in seconds Click here to continue Download Now! Please read the ...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Pediatr Neurol. 2007 Jul;37(1):47-50. 3-Hydroxy-3-methylglutaryl coenzyme a lyase deficiency with reversible white matter changes after treatment. Zafeiriou DI, Vargiami E, Mayapetek E, Augoustidou-Savvopoulou P, Mitchell GA. Â In this paper, the authors describe a patient with HMG-CoA Lyase deficiency. He initially presented at 8 months with seizures during a gastroenteritis; he had hepatomegaly and elevated […]. ...
The background to it is that UK has like 3 major TV/Cable/Phone providers (like Starhub back home) - British Telecom, Sky and Virgin Media. The rest of the telcos like Vodafone, O2 etc do some mobile and internet but not that comprehensive. Since there are these major providers who do everything, youd think that you can just call up one company and get it all done in one installation and one bill right? WRONG. Apparently, whilst everyone has 3-in-1 packages, for most of the internet here, its all through ADSL. And what does ADSL need? An active phone line. And heres the punchline - only BT provides the phone line. So that means that before you can do anything at all with anyone, you have to get BT to activate your phone line (and pay them while at it, this is the hidden cost that NO ONE tells you when you see all those cheap packages - £11/mth!!), which is why everyone ends up getting BT internet and phone. I was totally resisting this monopoly cos I really dont think I need a home phone ...
at home.. How to Change the TCP Window Size. The TCP Window Size for Windows XP can be optimized with programs like Tweakmaster or TCPOptimizer. While Tweakmaster is easier to handle, their registration process for the free version is somewhat dubious. TCPOptimizer is really free but only seems to be able to change the settings for all network cards at once instead of individually. Its also possible to change the parameters manually in the Windows registry. For network cards, the TCP receive window can be changed on a per adapter basis in the following registry key: HKEY_LOCAL_MACHINESYSTEMCurrentControlSetServicesTcpipParametersInterfacec{Interface ID}. If not already present, create a new DWORD called TcpWindowSize and assign it a value of 64240 (decimal). I also tried to set it to 128480 but for some reason the value is not accepted and the standard window size of 17520 bytes is still used after a restart.. For dial up connections things seem to be handled differently by the operating ...
Security updates or virus definitions? What first? I am connecting a Win2k PC, stand alone, to the Internet for the first time. ADSL. ...
Skys successful drive into broadband is set to shift up a gear in November when it will launch a package aimed at the UKs 10 million-plus Freeview households.. Sky Broadband launched last year after the group bought Easynet, but currently only supplies existing TV customers as part of a bundle. It offers up to theoretical 16MBit/s ADSL via the Easynet local loop unbundled network for £10 per month. Non-TV customers can expect to pay a bit more.. Multiple sources inside the company have indicated that Sky will pitch its standalone ISP service under a new brand called Picnic. Customers will be supplied with a Netgear DG834GT v4 router, which is currently being tested by Skys engineers for any glitches when connected to its network.. Internet brand protection outfit MarkMonitor has registered a series of domains including picnicbroadband.co.uk and picnicuser.co.uk. MarkMonitor ran a similar landgrab operation for Skys bundled broadband service.. We contacted Sky for their response to the ...
Your network card has an IP and your modem has an IP address if you connect to the Internet, but both is diffident because your LAN is not part of the internet. When you connect to Internet, depending on your connection, you get a fixed ( static ) IP or a dynamic IP. Modem users gets a IP address that changed every time they reconnect to internet, Very useful if you attack people, so if you disconnect, then you get a diffident IP. If you have a ISDN or maybe ADSL connection most of the time you will get a static IP, so whenever you connect to internet you get the same IP every time. Attack someone without IP spoofing, they will be able to see it is your IP attacking them! They can then go to your ISP ( internet service provider ), check who does this IP belong to and you can get into trouble. This is where modem users are lucky, they dont have a static IP and then can go mad and attack people and so without being caught, well almost... Their ISP can still check who was using the certain IP for ...
This step is catalyzed by adenylosuccinate lyase. Inosine monophosphate is converted to guanosine monophosphate by the ... First, GTP hydrolysis fuels the addition of aspartate to IMP by adenylosuccinate synthase, substituting the carbonyl oxygen for ... a nitrogen and forming the intermediate adenylosuccinate. Fumarate is then cleaved off forming adenosine monophosphate. ...
Adenylosuccinate lyase deficiency Extremophile Guthrie test YlbH leader Euzéby JP (2008). "Bacillus". List of Prokaryotic names ...
... of a Mutant Bacillus subtilis Adenylosuccinate Lyase Equivalent to a Mutant Enzyme Found in Human Adenylosuccinate Lyase ... "Evaluation of Types of Interactions in Subunit Association in Bacillus subtilis Adenylosuccinate Lyase". Biochemistry. 47 (9): ...
GMP back into IMP adenylosuccinate synthase converts IMP to adenylosuccinate adenylosuccinate lyase converts adenylosuccinate ... CAIR + L-Aspartate + ATP → SAICAR + ADP + Pi The eight is catalyzed by adenylosuccinate lyase. SAICAR → AICAR + Fumarate The ...
... this is subsequently acted upon by adenylosuccinate synthase and adenylosuccinate lyase, in a two step process, to convert it ... kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum". Biochimica et Biophysica Acta (BBA) - ...
... untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency". Am. J. Hum. Genet. 71 (1): 14- ...
... anemia due to Adenylosuccinate lyase deficiency Adie syndrome Adiposis dolorosa, aka Dercum's disease Adolescent benign focal ...
Autism spectrum Cerebral palsy Rett syndrome Mowat-Wilson syndrome Adenylosuccinate lyase deficiency Pitt-Hopkins syndrome ...
... a molecule whose appearance is characteristic of the disease adenylosuccinate lyase deficiency Saica may refer to: Saica (bug ...
Adenylosuccinate + GDP + Pi Finally, Adenylosuccinate is cleaved by the enzyme adenylosuccinate lyase to release fumarate and ... to sustain mitochondrial membrane potential during anoxic stress by utilizing fumarate produced by adenylosuccinate lyase as an ... NH4+ The second stage is the formation of adenylosuccinate from IMP and the amino acid aspartate, which is coupled to the ... regenerate the starting material of AMP: Adenylosuccinate → AMP + Fumarate A recent study conducted by Sridharan et al. (AJP ...
... lyase deficiency Purine nucleotide cycle Figures 20.4 and 20.7 in Textbook of Biochemistry, with clinical ... Adenylosuccinate is an intermediate in the interconversion of purine nucleotides inosine monophosphate (IMP) and adenosine ... monophosphate (AMP). The enzyme adenylosuccinate synthase carries out the reaction by the addition of aspartate to IMP and ...
Adenylosuccinase, EC 4.3.2.2 (adenylosuccinate lyase), which catalyzes the eighth step in the de novo biosynthesis of purines, ... Fumarate lyase is a substrate of the lyase class of enzymes. It been shown to share a short conserved sequence around a ... Aspartate ammonia-lyase, EC 4.3.1.1 (aspartase), which catalyzes the reversible conversion of aspartate to fumarate and ammonia ... Delta-crystallin shares around 90% sequence identity with arginosuccinate lyase, showing that it is an example of a 'hijacked' ...
... (or adenylosuccinase) is an enzyme that in humans is encoded by the ADSL gene. Adenylosuccinate lyase ... Mutated adenylosuccinate lyase (ASL) causes clinical disease in patients that is referred to as adenylosuccinate lyase ... "The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase ... of a mutant Bacillus subtilis adenylosuccinate lyase equivalent to a mutant enzyme found in human adenylosuccinate lyase ...
Adenylosuccinate Adenylosuccinate lyase List of genetic disorders Online Mendelian Inheritance in Man (OMIM): 103050 " ... Treatment of adenylosuccinate lyase deficiency can be done via epilepsy management with anticonvulsive drugs. Additionally the ... Adenylosuccinate lyase deficiency, is a rare autosomal recessive metabolic disorder characterized by the appearance of ... "Orphanet: Adenylosuccinate lyase deficiency". www.orpha.net. Retrieved 22 December 2016. CS1 maint: discouraged parameter (link ...
... tyrosine phenol-lyase MeSH D08.811.520.232.300 - amidine-lyases MeSH D08.811.520.232.300.200 - adenylosuccinate lyase MeSH ... chondroitin lyases MeSH D08.811.520.241.700.350.500.500 - chondroitin abc lyase MeSH D08.811.520.241.700.512 - heparin lyase ... ammonia-lyases MeSH D08.811.520.232.400.200 - aspartate ammonia-lyase MeSH D08.811.520.232.400.350 - ethanolamine ammonia-lyase ... lyase MeSH D08.811.520.241.300 - hydro-lyases MeSH D08.811.520.241.300.050 - aconitate hydratase MeSH D08.811.520.241.300.050. ...
Adenylosuccinate synthase. *Adenylosuccinate lyase. *reverse *AMP deaminase. IMP→GMP:. *IMP dehydrogenase. *GMP synthase ...
Adenylosuccinate lyase deficiency. *Adenosine Monophosphate Deaminase Deficiency type 1. Nucleotide salvage. *Lesch-Nyhan ...
Adenylosuccinate lyase deficiency. *Adenosine Monophosphate Deaminase Deficiency type 1. Nucleotide salvage. *Lesch-Nyhan ...
Adenylosuccinate lyase deficiency. *Adermatoglyphia. *Adhesive capsulitis of shoulder. *Adie syndrome. *Adipose tissue neoplasm ...
Adenylosuccinate lyase deficiency. *Pitt-Hopkins syndrome. *Phelan-McDermid syndrome. *Prader-Willi syndrome ...
... argininosuccinate lyase EC 4.3.2.2: adenylosuccinate lyase EC 4.3.2.3: ureidoglycolate lyase EC 4.3.2.4: purine imidazole-ring ... pectin lyase EC 4.2.2.11: poly(a-L-guluronate) lyase EC 4.2.2.12: xanthan lyase EC 4.2.2.13: exo-(1-4)-α-D-glucan lyase EC 4.2. ... pectate lyase EC 4.2.2.3: poly(b-D-mannuronate) lyase EC 4.2.2.4: chondroitin ABC lyase EC 4.2.2.5: chondroitin AC lyase EC 4.2 ... oligogalacturonide lyase EC 4.2.2.7: heparin lyase EC 4.2.2.8: heparin-sulfate lyase EC 4.2.2.9: pectate disaccharide-lyase EC ...
... lyase) ligase EC 6.2.1.23: dicarboxylate-CoA ligase EC 6.2.1.24: phytanate-CoA ligase EC 6.2.1.25: benzoate-CoA ligase EC 6.2. ... adenylosuccinate synthase EC 6.3.4.5: argininosuccinate synthase EC 6.3.4.6: urea carboxylase EC 6.3.4.7: ribose-5-phosphate- ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ...
EC4 Lyases (list). *EC5 Isomerases (list). *EC6 Ligases (list). *EC7 Translocases (list) ... Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ...
It is also said that a synthase is a lyase (a lyase is an enzyme that catalyzes the breaking of various chemical bonds by means ... Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ...
Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ...
2-hydroxyphytanoyl-CoA lyase. *2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase ...
EC4 Lyases (list). *EC5 Isomerases (list). *EC6 Ligases (list). *EC7 Translocases (list) ... Adenylosuccinate synthase. *Argininosuccinate synthase. *Holocarboxylase synthetase. *GMP synthase. *Asparagine synthetase. * ...
Adenylosuccinate lyase deficiency is a neurological disorder that causes brain dysfunction (encephalopathy) leading to delayed ... medlineplus.gov/genetics/condition/adenylosuccinate-lyase-deficiency/ Adenylosuccinate lyase deficiency. ... All forms of adenylosuccinate lyase deficiency are caused by mutations in the ADSL gene. This gene provides instructions for ... Adenylosuccinate lyase deficiency type I (also known as the severe form) is the most common. The signs and symptoms of this ...
Adenylosuccinate lyase (or adenylosuccinase) is an enzyme that in humans is encoded by the ADSL gene. Adenylosuccinate lyase ... Mutated adenylosuccinate lyase (ASL) causes clinical disease in patients that is referred to as adenylosuccinate lyase ... "The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase ... of a mutant Bacillus subtilis adenylosuccinate lyase equivalent to a mutant enzyme found in human adenylosuccinate lyase ...
Definition of adenylosuccinate lyase. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... adenylosuccinate lyase. Pronunciation: ad′e-nil-ō-sŭk′sin-āt lī′ās ...
Adenylosuccinate Adenylosuccinate lyase List of genetic disorders Online Mendelian Inheritance in Man (OMIM): 103050 " ... Treatment of adenylosuccinate lyase deficiency can be done via epilepsy management with anticonvulsive drugs. Additionally the ... Adenylosuccinate lyase deficiency, is a rare autosomal recessive metabolic disorder characterized by the appearance of ... "Orphanet: Adenylosuccinate lyase deficiency". www.orpha.net. Retrieved 22 December 2016. CS1 maint: discouraged parameter (link ...
Adenylosuccinate lyase C-terminal (IPR019468). Short name: AdenyloSucc_lyase_C Overlapping homologous superfamilies *L- ... Adenylosuccinate lyase catalyses two steps in the synthesis of purine nucleotides: the conversion of succinylaminoimidazole- ... This entry represents the seven alpha-helical, C-terminal domain of adenylosuccinate lyase [PMID: 9274883]. It is also found in ... Adenylosuccinate lyase deficiency: the first identified polish patient.. Brain Dev. 29 600-2 2007 ...
IPR022761 Fumarate_lyase_N. IPR008948 L-Aspartase-like. IPR004769 Pur_lyase. Pfami. View protein in Pfam. PF00206 Lyase_1, 1 ... IPR020557 Fumarate_lyase_CS. IPR000362 Fumarate_lyase_fam. IPR022761 Fumarate_lyase_N. IPR008948 L-Aspartase-like. IPR004769 ... Adenylosuccinate lyaseImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p ... tr,E9Q3T7,E9Q3T7_MOUSE Adenylosuccinate lyase OS=Mus musculus OX=10090 GN=Adsl PE=1 SV=1 ...
Adenylosuccinate lyase (purB), Adenylosuccinate lyase (purB_1), Adenylosuccinate lyase (pcaB_2), Adenylosuccinate lyase (EA770_ ... Adenylosuccinate lyase (purB), Adenylosuccinate lyase (purB_1), Adenylosuccinate lyase (pcaB_2), Adenylosuccinate lyase (EA770_ ... 10675), Adenylosuccinate lyase (purB), Adenylosuccinate lyase (purB_1), Adenylosuccinate lyase (purB_2), Adenylosuccinate lyase ... 10675), Adenylosuccinate lyase (purB), Adenylosuccinate lyase (purB_1), Adenylosuccinate lyase (purB_2), Adenylosuccinate lyase ...
The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three ... ADENYLOSUCCINATE LYASE A 431 Bacillus subtilis EC#: 4.3.2.2 IUBMB Gene Name(s): purB purE BSU06440 ...
The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three ... Adenylosuccinate lyase 1392 4.3.2.2 , Details 4 5HW2 1 A, B, C, D Adenylosuccinate lyase 263 4.3.2.2 , Details ... Adenylosuccinate lyase 263 4.3.2.2 , Details 3 2PFM 1 A, B ... ADENYLOSUCCINATE LYASE 13773 4.3.2.2 , Details 8 5XNZ 1 A CreD ... PROTEIN (ADENYLOSUCCINATE LYASE) 2336 4.3.2.2 , Details 2 4EEI 1 A, B ...
View Rabbit Monoclonal anti-Adenylosuccinate Lyase Antibody (007) [Alexa Fluor® 594] (NBP2-89878AF594). Validated Applications ... Additional Adenylosuccinate Lyase Products. Array NBP2-89878AF594 * Adenylosuccinate Lyase Antibodies. * Adenylosuccinate Lyase ... Home » Adenylosuccinate Lyase » Adenylosuccinate Lyase Antibodies » Adenylosuccinate Lyase Antibody (007) [Alexa Fluor® 594] ... Blogs on Adenylosuccinate Lyase. There are no specific blogs for Adenylosuccinate Lyase, but you can read our latest blog posts ...
... and Adenylosuccinate Lyase (ADSL), to evaluate the host immune response, as well as the parasite load after vaccination. For ... and Adenylosuccinate Lyase (ADSL), to evaluate the host immune response, as well as the parasite load after vaccination. For ... Adenylosuccinate lyase of Schistosoma mansoni: gene structure, mRNA expression, and analysis of the predicted peptide structure ... Kmoch S. Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure ...
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... catalysing the nonhydrolytic cleavage of succinyl groups from SAICA ribotide and adenylosuccinate. Enzyme defects are ... Adenylosuccinate lyase is an enzyme of fumarase superfamily that participates in the purine biosynthetic pathway, ... Inhibition of defective adenylosuccinate lyase by HNE: A neurological disease that may be affected by oxidative stress Issue ... Adenylosuccinate lyase activity is lost to a different extent in the patients. Diminished levels of enzyme have been attributed ...
Human Adenylosuccinate lyase (ADSL) ELISA Kit-YP_004341812.1 (MBS7236022) product datasheet at MyBioSource, ELISA Kits ... ADSL elisa kit :: Human Adenylosuccinate lyase (ADSL) ELISA Kit. Catalog #. MBS7236022 .mycenter { display: block; margin-left ... Kit for analyzing the presence of the Adenylosuccinate lyase (ADSL) ELISA Kit target analytes in biological samples. The ... Adenylosuccinate lyase (ADSL), ELISA Kit. ★Popular Item★ Also Known As Human Adenylosuccinate lyase (ADSL) ELISA Kit. ...
Adenylosuccinate lyase,Adl,Adsl,ASase,ASL,Mouse,Mus musculus \ EIAAB33171 for more molecular products just contact us ... Adenylosuccinate lyase,Adl,Adsl,ASase,ASL,Mouse,Mus musculus mus musculus murine Adenylosuccinase,Adenylosuccinate lyase,Adl, ... Adenylosuccinate lyase,Adl,Adsl,ASase,ASL,Mouse,Mus musculus. Related products : Adenylosuccinase,Adenylosuccinate lyase,Adl, ... Adenylosuccinate lyase,Adl,Adsl,ASase,ASL,Mouse,Mus musculus / Product Detail : EIAAB33171 Adenylosuccinase,Adenylosuccinate ...
Showing Protein Adenylosuccinate lyase (BMDBP00935). IdentificationBiological propertiesGene propertiesProtein properties ...
Get natural cures for Adenylosuccinate lyase deficiency that can make a difference in your life or the life of someone you love ... Adenylosuccinate lyase deficiency by state. Adenylosuccinate lyase deficiency in Alabama. Adenylosuccinate lyase deficiency in ... Adenylosuccinate lyase deficiency in Iowa. Adenylosuccinate lyase deficiency in Kansas. Adenylosuccinate lyase deficiency in ... Adenylosuccinate lyase deficiency in North Dakota. Adenylosuccinate lyase deficiency in Ohio. Adenylosuccinate lyase deficiency ...
adenylosuccinate lyase. Enable Javascript to view the expand/collapse boxes.. Printable PDF Open All Close All ... OMIM: ADENYLOSUCCINATE LYASE. *. Ariyananda Lde Z, Lee P, Antonopoulos C, Colman RF. Biochemical and biophysical analysis of ... A reduction of adenylosuccinate lyase function, possibly due to a shortage of purinosomes, leads to buildup of SAICAR and SAMP ... Adenylosuccinate lyase and other enzymes involved in purine synthesis form a group of proteins (a protein complex) called the ...
Adenylosuccinate Lyase, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human ... orf clones - Search for available Adenylosuccinate Lyase ORF products * Overview of 142 available Adenylosuccinate Lyase gene ... orf clones - Search for available Adenylosuccinate Lyase ORF products * Overview of 142 available Adenylosuccinate Lyase gene ... orf clones - Search for available Adenylosuccinate Lyase ORF products. *Overview of 142 available Adenylosuccinate Lyase gene ...
... and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis. ... and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis. In adenylosuccinate lyase from Bacillus ... 15182182] Gln212, Asn270, and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis.. ... metC yjcJ BSU11880] Cystathionine beta-lyase MetC (CBL) (EC 4.4.1.13) (Beta-cystathionase MetC) (Cysteine lyase MetC) (Cysteine ...
Adenylosuccinate Lyase Deficiency (disorder) (2). *. Atrophy (2). *. Autistic Disorder (2). *. Cholangiocarcinoma (2) ...
Adenylosuccinate lyase. Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) ... Adenylosuccinate lyase UniProtKBInterProSTRINGInteractive Modelling. 482 aa; Sequence (Fasta) Identical sequences: ...
fliD, flagellin gene; NA, not applicable; oppA2, oligopeptide permease periplasmic A2 gene; purB, adenylosuccinate lyase gene; ...
Adenylosuccinate Lyase 4.3.2.2. ADP-Ribosylcyclase none. Agarase 3.2.1.81. Alanine Aminopeptidase 3.4.11.14. ...
adenylosuccinate lyase. MGI:103202 Go Annotations as Summary Text (Tabular View) (GO Graph). Automated description from the ... Orthologous to human ADSL (adenylosuccinate lyase).. Go Annotations in Tabular Form (Text View) (GO Graph) Filter annotations ... Predicted to have (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity ... Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency. ...
Adenylosuccinate Lyase Deficiency. *Adie Syndrome. *ADNP Syndrome. *Adult Neuronal Ceroid Lipofuscinosis. *Adult Onset Stills ...
ADA, Adenosine deaminase; ADK, Adenosine kinase; ADSL, adenylosuccinate lyase; APRT, adenine phosphorybosyl-transferase; ATIC, ... and of adenylosuccinate (S-AMP) to AMP. Altered function of ADSL leads to the accumulation of succinyl-purines in body fluids, ... adenosylosuccinate lyase (ADSL) and AICAR transformylase/IMP cyclohydrolase (ATIC). ADSL catalyzes both the conversion of ... adenylosuccinate; SAICAR: succinylaminoimidazole carboxamide ribotide; XO, xanthine oxydase; UK, uridine kinase; UMPS, UMP ...
adenylosuccinate synthase converts IMP to adenylosuccinate. *adenylosuccinate lyase converts adenylosuccinate into AMP ...
Adenylosuccinate lyase deficiency (rare). Atypical PKU (e.g., biopterin defects [rare]). Molybdenum cofactor deficiency or ...
  • Adenylosuccinate lyase deficiency is a neurological disorder that causes brain dysfunction (encephalopathy) leading to delayed development of mental and movement abilities (psychomotor delay), autistic behaviors that affect communication and social interaction, and seizures. (medlineplus.gov)
  • Adenylosuccinate lyase deficiency is classified into three forms based on the severity of the signs and symptoms. (medlineplus.gov)
  • Adenylosuccinate lyase deficiency type I (also known as the severe form) is the most common. (medlineplus.gov)
  • In individuals with adenylosuccinate lyase deficiency type II (also known as the moderate or mild form), development is typically normal for the first few years of life but then slows. (medlineplus.gov)
  • All forms of adenylosuccinate lyase deficiency are caused by mutations in the ADSL gene. (medlineplus.gov)
  • Most of the mutations involved in adenylosuccinate lyase deficiency change single protein building blocks (amino acids) in the adenylosuccinate lyase enzyme, which impairs its function. (medlineplus.gov)
  • damage to brain tissue caused by one or both of these substances likely underlies the neurological problems that occur in adenylosuccinate lyase deficiency. (medlineplus.gov)
  • Studies suggest that the amount of SAICAr relative to S-Ado reflects the severity of adenylosuccinate lyase deficiency. (medlineplus.gov)
  • Point mutations in adenylosuccinate that cause lowered enzymatic activity cause clinical symptoms that mark the condition adenylosuccinate lyase deficiency. (wikipedia.org)
  • Adenylosuccinate lyase deficiency: the first identified polish patient. (ebi.ac.uk)
  • Adenylosuccinate lyase deficiency, is a rare autosomal recessive metabolic disorder characterized by the appearance of succinylaminoimidazolecarboxamide riboside (SAICA riboside) and succinyladenosine (S-Ado) in cerebrospinal fluid, urine. (wikipedia.org)
  • Among the signs and symptoms of adenylosuccinate lyase deficiency are the following: Aggressive behavior Microcephaly Autism Brachycephaly Mild Cerebellar hypoplasia Seizures Adenylosuccinate lyase deficiency is responsible for a range of symptoms that involve psychomotor retardation, often accompanied by epileptic seizures, and autistic features. (wikipedia.org)
  • Treatment of adenylosuccinate lyase deficiency can be done via epilepsy management with anticonvulsive drugs. (wikipedia.org)
  • Adenylosuccinate lyase deficiency is a type of disorder of the purine metabolism that affects patients both behaviorally and biochemically. (naturalcurefor.com)
  • More than 50 mutations in the ADSL gene have been found to cause adenylosuccinate lyase deficiency. (nih.gov)
  • Detection of these substances in body fluids can help with diagnosis of adenylosuccinate lyase deficiency. (nih.gov)
  • Structural and biochemical characterization of human adenylosuccinate lyase (ADSL) and the R303C ADSL deficiency-associated mutation. (nih.gov)
  • Zikanova M, Skopova V, Hnizda A, Krijt J, Kmoch S. Biochemical and structural analysis of 14 mutant adsl enzyme complexes and correlation to phenotypic heterogeneity of adenylosuccinate lyase deficiency. (nih.gov)
  • Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency. (jax.org)
  • Succinyladenosine (SAdo) is one of the dephosphorylated enzyme substrate that accumulates in body fluids of patients with adenylosuccinate lyase (ADSL) deficiency, the other being 5-amino-4-imidazole-N-succinocarboxamide riboside (SAICAr). (hmdb.ca)
  • Jack is five years old and has a very rare genetic disorder called adenylosuccinate lyase deficiency. (jeansforgenesday.org)
  • Adenylosuccinate lyase deficiency (ADSL deficiency) is a disorder of purine metabolism characterized by intellectual disability, psychomotor delay and/or regression, seizures, and autistic features. (mendelian.co)
  • Adenylosuccinate lyase (or adenylosuccinase) is an enzyme that in humans is encoded by the ADSL gene. (wikipedia.org)
  • Adenylosuccinate lyase, or adenylosuccinase , catalyzes two reactions in the biosynthesis of purine nucleotides. (thefreedictionary.com)
  • Adenylosuccinase, EC:4.3.2.2 (adenylosuccinate lyase) [ PMID: 1574589 ], which catalyses the eighth step in the de novo biosynthesis of purines, the formation of 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide and fumarate from 1-(5-phosphoribosyl)-4-(N-succino-carboxamide). (ebi.ac.uk)
  • These two succinylpurines are the dephosphorylated derivatives of SAICA ribotide (SAICAR) and adenylosuccinate (S-AMP), the two substrates of adenylosuccinate lyase (ADSL), which catalyzes an important reaction in the de novo pathway of purine biosynthesis. (wikipedia.org)
  • Thus, the objective of this study was to evaluate the effect of immunization with recombinant functional enzymes of the purine salvage pathway of S. mansoni , Nucleoside Diphosphate Kinase (NDPK) and Adenylosuccinate Lyase (ADSL), to evaluate the host immune response, as well as the parasite load after vaccination. (frontiersin.org)
  • MBS7236022 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Adenylosuccinate lyase (ADSL) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • The ADSL gene provides instructions for making an enzyme called adenylosuccinate lyase. (nih.gov)
  • ADSL (Adenylosuccinate Lyase) is a Protein Coding gene. (genecards.org)
  • Orthologous to human ADSL (adenylosuccinate lyase). (jax.org)
  • This study was designed to investigate the effect of Adenylosuccinate Lyase (ADSL) gene on Inosine Monophosphate content (IMP) in chicken. (scialert.net)
  • Adenylosuccinate lyase (ADSL) is an essential enzyme for de novo purine biosynthesis and the purine nucleotide cycle. (unispital-basel.ch)
  • The mutations include those in purB (adenylosuccinate lyase, adenine requirement) ( 16 ) and icdA (isocitrate dehydrogenase, glutamate requirement) ( 17 ) and others causing requirements for methionine or cysteine ( 17 ). (asm.org)
  • Biochemical and biophysical analysis of five disease-associated human adenylosuccinate lyase mutants. (medlineplus.gov)
  • Adenylosuccinate synthase (EC 6.3.4.4) catalyzes the first reaction of AMP biosynthesis at IMP branching point. (springer.com)
  • Previous investigations in this laboratory showed transformation-linked increase of adenylosuccinate synthase activity in rat transplantable hepatomas and kidney tumors. (springer.com)
  • separated two isozymes of adenylosuccinate synthase in rat liver and characterized that the acidic isozyme has a lower K m for IMP than the basic isozyme. (springer.com)
  • 7 These findings directed our attention to the neoplastic expression of the isozyme program of adenylosuccinate synthase in cancer tissues. (springer.com)
  • The present study shows the consistent pattern of the isozyme shift to the acidic adenylosuccinate synthase in rat experimental tumors, human hepatocellular carcinoma and colon adenocarcinoma. (springer.com)
  • Ikegami T., Natsumeda Y., Weber G. (1989) Isozyme Shift of Adenylosuccinate Synthase in Rat and Human Neoplasms. (springer.com)
  • R.C. Jackson, H.P. Morris, and G. Weber, Neoplastic transformation linked alterations in adenylosuccinate synthetase activity, Biochem. (springer.com)
  • Y. Matsuda, H. Ogawa, S. Fukutome, H. Shiraki, and H. Nakagawa, Adenylosuccinate synthetase in rat liver: the existence of two types and their regulatory roles, Biochem. (springer.com)
  • Y. Matsuda, H. Shiraki, H. Ogawa, and H. Nakagawa, Change in content of adenylosuccinate synthetase isozymes during liver regeneration in rats, Biochim. (springer.com)
  • Mehrotra S and Balaram H, Kinetic characterization of adenylosuccinate synthetase from the thermophilic archaea Methanocaldococcus jannaschii, Biochemistry 46 , 12821 - 12832 (2007). (jncasr.ac.in)
  • Adenylosuccinate lyase converts a molecule called succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and converts succinyladenosine monophosphate (SAMP) to adenosine monophosphate (AMP). (medlineplus.gov)
  • ASL cleaves adenylosuccinate into AMP and fumarate, and cleaves SAICAR into AICAR and fumarate. (wikipedia.org)
  • A reduction of adenylosuccinate lyase function, possibly due to a shortage of purinosomes, leads to buildup of SAICAR and SAMP. (nih.gov)
  • It is an essential enzyme involved in purine metabolism, and catalyzes two non-sequential reactions in the de novo purine biosynthetic pathway: the conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) to aminoimidazole carboxamide ribotide (AICAR) and the conversion of adenylosuccinate (S-AMP) to aden. (genecards.org)
  • Adenylosuccinate lyase (ASL) is an enzyme from the purine-biosynthetic pathway that catalyzes the cleavage of 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) to 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) and fumarate. (embl.de)
  • Adenylosuccinate lyase converts adenylosuccinate to AMP and fumarate as part of the purine nucleotide cycle. (wikipedia.org)
  • AICAR proceeds through three more reactions before it becomes adenylosuccinate (also called succinyladenosine monophosphate or SAMP), which ASL then splits into adenosine monophosphate (AMP) and fumarate. (wikipedia.org)
  • In the ASL-catalyzed reaction splitting adenylosuccinate into adenosine monophosphate (AMP) and fumarate, the AMP must rotate slightly after the reaction is complete and before fumarate is released in order for both products to fit in the active site. (wikipedia.org)
  • Gene Ontology (GO) annotations related to this gene include N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity and (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity . (genecards.org)
  • Predicted to have (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity and N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. (jax.org)
  • A number of enzymes, belonging to the lyase class, for which fumarate is a substrate, have been shown to share a short conserved sequence around a methionine which is probably involved in the catalytic activity of this type of enzymes [ PMID: 3282546 ]. (ebi.ac.uk)
  • Arginosuccinase, EC:4.3.2.1 (argininosuccinate lyase), which catalyses the formation of arginine and fumarate from argininosuccinate, the last step in the biosynthesis of arginine. (ebi.ac.uk)
  • Aspartate ammonia-lyase, EC:4.3.1.1 (aspartase), which catalyses the reversible conversion of aspartate to fumarate and ammonia. (ebi.ac.uk)
  • That enzyme can also catalyse the formation of fumarate and AMP from adenylosuccinate. (ebi.ac.uk)
  • Adenylosuccinate lyase and other enzymes involved in purine synthesis form a group of proteins (a protein complex) called the purinosome. (nih.gov)
  • Most of the mutations involved in this condition change single protein building blocks (amino acids) in the adenylosuccinate lyase enzyme. (nih.gov)
  • The protein encoded by this gene belongs to the lyase 1 family. (genecards.org)
  • Delta-crystallin shares around 90% sequence identity with arginosuccinate lyase, showing that it is an example of a 'hijacked' enzyme - accumulated mutations have, however, rendered the protein enzymatically inactive. (ebi.ac.uk)
  • the formation of adenosine monophosphate (AMP) from adenylosuccinate (the final step in the synthesis of AMP from IMP) [ PMID: 17485188 ]. (ebi.ac.uk)
  • Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. (bio-rad.com)
  • It was previously thought that the mechanism of action for adenylosuccinate lyase was a concerted catalysis where the hydrogen on the β-carbon (with respect to the leaving nitrogen) was abstracted by the catalytic base at the same time that the leaving nitrogen was protonated by the catalytic acid for E2 elimination. (wikipedia.org)
  • His89 seems to enhance the binding of the substrate's phosphoryl group and orient adenylosuccinate for catalysis. (wikipedia.org)
  • Gentaur antibody-antibodies.com The Marketplace for Antibodies : Gln212, Asn270, and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis. (antibody-antibodies.com)
  • As supported by computer modeling, the studies presented here indicate that Gln(212), Asn(270), and Arg(301) are indispensable to catalysis by adenylosuccinate lyase and probably interact noncovalently with the carboxylate anions of the substrates 5-aminoimidazole-4(N-succinylocarboxamide)ribonucleotide and adenylosuccinate, optimizing their bound orientations. (antibody-antibodies.com)
  • Adenylosuccinate lyase in humans and Bacillus subtilis can be competitively inhibited by the substrate analog adenosine phosphonobutyric acid 2'(3'), 5'-diphosphate (APBADP). (wikipedia.org)
  • In adenylosuccinate lyase from Bacillus subtilis, Gln(212), Asn(270), and Arg(301) are conserved and located close to the succinyl moiety of docked adenylosuccinate. (antibody-antibodies.com)
  • Adenylosuccinate lyase mutants can have considerably reduced activity whether the mutation is in or away from the active site. (wikipedia.org)
  • Adenylosuccinate binding studies of the other mutants revealed greatly weakened affinities that contributed to, but did not account entirely for, the loss of activity. (antibody-antibodies.com)
  • This entry represents the seven alpha-helical, C-terminal domain of adenylosuccinate lyase [ PMID: 9274883 ]. (ebi.ac.uk)
  • Characterisation of the gene encoding adenylosuccinate lyase of Plasmodium falciparum. (ebi.ac.uk)
  • Adenylosuccinate lyase is an enzyme of fumarase superfamily that participates in the purine biosynthetic pathway, catalysing the nonhydrolytic cleavage of succinyl groups from SAICA ribotide and adenylosuccinate. (iospress.com)
  • APBADP is a competitive inhibitor for both of the reactions catalyzed by adenylosuccinate lyase, and kinetic studies with APBADP show that the substrates for both reactions use the same active site. (wikipedia.org)
  • Adenylosuccinate lyase is part of the β-elimination superfamily of enzymes and it proceeds through an E1cb reaction mechanism. (wikipedia.org)
  • The team looked at an interesting human mutation that leads to amino acid substitution in adenylosuccinate lyase, an enzyme involved in the synthesis of purine inside DNA. (phys.org)
  • The structure of phosphate-bound Escherichia coli adenylosuccinate lyase identifies His171 as a catalytic acid. (embl.de)
  • The crystal structure of adenylosuccinate lyase (ASL) from Thermatoga maritima. (digitaljournal.com)
  • It is suggested that inactivation of defective adenylosuccinate lyase by HNE and other membrane peroxidation products may account, at least in part, for the impairment of neurological functions and recurrent worsening of the symptoms. (iospress.com)
  • Adenylosuccinate lyase (ASL) is an enzyme that catalyzes two reactions in the de novo purine biosynthetic pathway. (wikipedia.org)
  • Colman's lab studies the enzyme glutathione S-transferase, which plays an important role in detoxifying foreign chemicals, and adenylosuccinate lyase, a shortage of which is related to mental retardation and autism. (asbmb.org)