Species of the genus MASTADENOVIRUS, causing a wide range of diseases in humans. Infections are mostly asymptomatic, but can be associated with diseases of the respiratory, ocular, and gastrointestinal systems. Serotypes (named with Arabic numbers) have been grouped into species designated Human adenovirus A-F.
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses.
Proteins transcribed from the E1A genome region of ADENOVIRUSES which are involved in positive regulation of transcription of the early genes of host infection.
Virus diseases caused by the ADENOVIRIDAE.
Proteins encoded by adenoviruses that are synthesized prior to, and in the absence of, viral DNA replication. The proteins are involved in both positive and negative regulation of expression in viral and cellular genes, and also affect the stability of viral mRNA. Some are also involved in oncogenic transformation.
Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression.
Proteins transcribed from the E3 region of ADENOVIRUSES but not essential for viral replication. The E3 19K protein mediates adenovirus persistence by reducing the expression of class I major histocompatibility complex antigens on the surface of infected cells.
Proteins transcribed from the E4 region of ADENOVIRUSES. The E4 19K protein transactivates transcription of the adenovirus E2F protein and complexes with it.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The very first viral gene products synthesized after cells are infected with adenovirus. The E1 region of the genome has been divided into two major transcriptional units, E1A and E1B, each expressing proteins of the same name (ADENOVIRUS E1A PROTEINS and ADENOVIRUS E1B PROTEINS).
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Species of the genus MASTADENOVIRUS that causes fever, edema, vomiting, and diarrhea in dogs and encephalitis in foxes. Epizootics have also been caused in bears, wolves, coyotes, and skunks. The official species name is Canine adenovirus and it contains two serotypes.
Proteins transcribed from the E2 region of ADENOVIRUSES. Several of these are required for viral DNA replication.
A genus of ADENOVIRIDAE that infects MAMMALS including humans and causes a wide range of diseases. The type species is Human adenovirus C (see ADENOVIRUSES, HUMAN).
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Species of the genus MASTADENOVIRUS, causing neurological disease in pigs.
A species of MORBILLIVIRUS causing distemper in dogs, wolves, foxes, raccoons, and ferrets. Pinnipeds have also been known to contract Canine distemper virus from contact with domestic dogs.
A genus of ADENOVIRIDAE that infects birds. The type species is FOWL ADENOVIRUS A.
The type species of the genus AVIADENOVIRUS, family ADENOVIRIDAE, an oncogenic virus of birds. This is also called CELO virus for chick embryo lethal orphan virus.
Deoxyribonucleic acid that makes up the genetic material of viruses.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
Established cell cultures that have the potential to propagate indefinitely.
Proteins that form the CAPSID of VIRUSES.
A species of the genus PARVOVIRUS and a host range variant of FELINE PANLEUKOPENIA VIRUS. It causes a highly infectious fulminating ENTERITIS in dogs producing high mortality. It is distinct from CANINE MINUTE VIRUS, a species in the genus BOCAVIRUS. This virus can also infect cats and mink.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Use of attenuated VIRUSES as ANTINEOPLASTIC AGENTS to selectively kill CANCER cells.
Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.
The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.
The third tooth to the left and to the right of the midline of either jaw, situated between the second INCISOR and the premolar teeth (BICUSPID). (Jablonski, Dictionary of Dentistry, 1992, p817)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Simultaneous inflammation of the cornea and conjunctiva.
Proteins found in any species of virus.
The functional hereditary units of VIRUSES.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.
Inflammation, often mild, of the conjunctiva caused by a variety of viral agents. Conjunctival involvement may be part of a systemic infection.
The outer protein protective shell of a virus, which protects the viral nucleic acid.
Vaccines used to prevent infection by any virus from the family ADENOVIRIDAE.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A species of CORONAVIRUS infecting dogs. Onset of symptoms is usually sudden and includes vomiting, diarrhea, and dehydration.
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. Helper and satellite may be of the same or different genus.
Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A name for several highly contagious viral diseases of animals, especially canine distemper. In dogs, it is caused by the canine distemper virus (DISTEMPER VIRUS, CANINE). It is characterized by a diphasic fever, leukopenia, gastrointestinal and respiratory inflammation and sometimes, neurologic complications. In cats it is known as FELINE PANLEUKOPENIA.
Ribonucleic acid that makes up the genetic material of viruses.
A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-galactosides. Deficiency of beta-Galactosidase A1 may cause GANGLIOSIDOSIS, GM1.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
A hereditary disease of the hip joints in dogs. Signs of the disease may be evident any time after 4 weeks of age.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A genus of the family PICORNAVIRIDAE whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated "human enterovirus".
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
The process by which a DNA molecule is duplicated.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Process of growing viruses in live animals, plants, or cultured cells.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A genus of ADENOVIRIDAE that comprises viruses of several species of MAMMALS and BIRDS. The type species is Ovine adenovirus D.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Elements of limited time intervals, contributing to particular results or situations.
A cell line derived from cultured tumor cells.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Substances elaborated by viruses that have antigenic activity.
A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).
An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Inflammation of the lung parenchyma that is caused by a viral infection.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, which are dependent on a coinfection with helper adenoviruses or herpesviruses for their efficient replication. The type species is Adeno-associated virus 2.
An abnormality in the direction of a TOOTH ERUPTION.
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
Proteins prepared by recombinant DNA technology.
Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals.
A ubiquitously expressed complement receptor that binds COMPLEMENT C3B and COMPLEMENT C4B and serves as a cofactor for their inactivation. CD46 also interacts with a wide variety of pathogens and mediates immune response.
INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.
The directional growth of an organism in response to an external stimulus such as light, touch, or gravity. Growth towards the stimulus is a positive tropism; growth away from the stimulus is a negative tropism. (From Concise Dictionary of Biology, 1990)
A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.
A tooth that is prevented from erupting by a physical barrier, usually other teeth. Impaction may also result from orientation of the tooth in an other than vertical position in the periodontal structures.
Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources. It includes the recombination joint or edge of a heteroduplex region where two recombining DNA molecules are connected.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.
This line KB is now known to be a subline of the ubiquitous KERATIN-forming tumor cell line HeLa. It was originally thought to be derived from an epidermal carcinoma of the mouth, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via contamination by HELA CELLS. The cells are positive for keratin by immunoperoxidase staining. KB cells have been reported to contain human papillomavirus18 (HPV-18) sequences.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Viruses that produce tumors.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
Injections introduced directly into localized lesions.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.
Tumors or cancer of the MOUTH.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The sum of the weight of all the atoms in a molecule.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.
The genetic unit consisting of three structural genes, an operator and a regulatory gene. The regulatory gene controls the synthesis of the three structural genes: BETA-GALACTOSIDASE and beta-galactoside permease (involved with the metabolism of lactose), and beta-thiogalactoside acetyltransferase.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A subfamily of the family MURIDAE comprised of 69 genera. New World mice and rats are included in this subfamily.
A normal developing tooth which has not yet perforated the oral mucosa or one that fails to erupt in the normal sequence or time interval expected for the type of tooth in a given gender, age, or population group.
A general term for diseases produced by viruses.
Methods of maintaining or growing biological materials in controlled laboratory conditions. These include the cultures of CELLS; TISSUES; organs; or embryo in vitro. Both animal and plant tissues may be cultured by a variety of methods. Cultures may derive from normal or abnormal tissues, and consist of a single cell type or mixed cell types.
A species of VARICELLOVIRUS virus that causes a disease in newborn puppies.
One of a pair of irregularly shaped bones that form the upper jaw. A maxillary bone provides tooth sockets for the superior teeth, forms part of the ORBIT, and contains the MAXILLARY SINUS.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
The genetic process of crossbreeding between genetically dissimilar parents to produce a hybrid.
The relationships of groups of organisms as reflected by their genetic makeup.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
The rate dynamics in chemical or physical systems.
Transcription factors that were originally identified as site-specific DNA-binding proteins essential for DNA REPLICATION by ADENOVIRUSES. They play important roles in MAMMARY GLAND function and development.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Tumors most commonly seen on or near the genitalia. They are venereal, most likely transmitted through transplantation of cells by contact. Metastases have been reported. Spontaneous regression may occur.
Proteins which are involved in the phenomenon of light emission in living systems. Included are the "enzymatic" and "non-enzymatic" types of system with or without the presence of oxygen or co-factors.
Virus infections caused by the PARVOVIRIDAE.
The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.
Defective viruses which can multiply only by association with a helper virus which complements the defective gene. Satellite viruses may be associated with certain plant viruses, animal viruses, or bacteriophages. They differ from satellite RNA; (RNA, SATELLITE) in that satellite viruses encode their own coat protein.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
Method for measuring viral infectivity and multiplication in CULTURED CELLS. Clear lysed areas or plaques develop as the VIRAL PARTICLES are released from the infected cells during incubation. With some VIRUSES, the cells are killed by a cytopathic effect; with others, the infected cells are not killed but can be detected by their hemadsorptive ability. Sometimes the plaque cells contain VIRAL ANTIGENS which can be measured by IMMUNOFLUORESCENCE.
An epithelial cell line derived from a kidney of a normal adult female dog.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Y-box-binding protein 1 was originally identified as a DNA-binding protein that interacts with Y-box PROMOTER REGIONS of MHC CLASS II GENES. It is a highly conserved transcription factor that regulates expression of a wide variety of GENES.
An alpha integrin with a molecular weight of 160-kDa that is found in a variety of cell types. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds. Integrin alphaV can combine with several different beta subunits to form heterodimers that generally bind to RGD sequence-containing extracellular matrix proteins.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Deoxycytidine (dihydrogen phosphate). A deoxycytosine nucleotide containing one phosphate group esterified to the deoxyribose moiety in the 2'-,3'- or 5- positions.
The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)
A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL). Human infections are confined almost entirely to children. This parasite is commonly seen in dogs, other Canidae, and porcupines with humans considered only an accidental host. Transmission is by Phlebotomus sandflies.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
Separation of particles according to density by employing a gradient of varying densities. At equilibrium each particle settles in the gradient at a point equal to its density. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.
A family of very small DNA viruses containing a single molecule of single-stranded DNA and consisting of two subfamilies: PARVOVIRINAE and DENSOVIRINAE. They infect both vertebrates and invertebrates.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Transport proteins that carry specific substances in the blood or across cell membranes.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.
An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.
Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.
Receptors such as INTEGRIN ALPHAVBETA3 that bind VITRONECTIN with high affinity and play a role in cell migration. They also bind FIBRINOGEN; VON WILLEBRAND FACTOR; osteopontin; and THROMBOSPONDINS.
A genus of ADENOVIRIDAE comprising species including viruses of frogs (FROGS AND TOADS) and TURKEYS. The type species is Frog adenovirus.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.

Cellular uptake and infection by canine parvovirus involves rapid dynamin-regulated clathrin-mediated endocytosis, followed by slower intracellular trafficking. (1/44)

Canine parvovirus (CPV) is a small, nonenveloped virus that is a host range variant of a virus which infected cats and changes in the capsid protein control the ability of the virus to infect canine cells. We used a variety of approaches to define the early stages of cell entry by CPV. Electron microscopy showed that virus particles concentrated within clathrin-coated pits and vesicles early in the uptake process and that the infecting particles were rapidly removed from the cell surface. Overexpression of a dominant interfering mutant of dynamin in the cells altered the trafficking of capsid-containing vesicles. There was a 40% decrease in the number of CPV-infected cells in mutant dynamin-expressing cells, as well as a approximately 40% decrease in the number of cells in S phase of the cell cycle, which is required for virus replication. However, there was also up to 10-fold more binding of CPV to the surface of mutant dynamin-expressing cells than there was to uninduced cells, suggesting an increased receptor retention on the cell surface. In contrast, there was little difference in virus binding, virus infection rate, or cell cycle distribution between induced and uninduced cells expressing wild-type dynamin. CPV particles colocalized with transferrin in perinuclear endosomes but not with fluorescein isothiocyanate-dextran, a marker for fluid-phase endocytosis. Cells treated with nanomolar concentrations of bafilomycin A1 were largely resistant to infection when the drug was added either 30 min before or 90 min after inoculation, suggesting that there was a lag between virus entering the cell by clathrin-mediated endocytosis and escape of the virus from the endosome. High concentrations of CPV particles did not permeabilize canine A72 or mink lung cells to alpha-sarcin, but canine adenovirus type 1 particles permeabilized both cell lines. These data suggest that the CPV entry and infection pathway is complex and involves multiple vesicular components.  (+info)

Nedocromil sodium inhibits canine adenovirus bronchiolitis in beagle puppies. (2/44)

Nedocromil sodium is a nonsteroidal anti-inflammatory drug used to control asthmatic attacks. Our hypothesis is that nedocromil sodium inhibits virus-induced airway inflammation, a common trigger of asthma. We nebulized nedocromil sodium into beagle dogs (n = 10, mean +/- SEM ages: 149 +/- 13 days) before and after inoculation with canine adenovirus type 2 (CAV2). Control dogs (n = 10) received saline aerosols and were either infected with CAV2 (Sal/CAV2, n = 7, mean +/- SEM ages: 140 +/- 11 days) or were not infected (Sal/Sal, n = 3, ages: 143 +/- 0 days). All dogs were anesthetized with choralose (80 mg/kg i.v.), intubated, and mechanically ventilated. Pulmonary function tests and bronchoalveolar lavage (BAL) were performed using standard techniques. Pulmonary function tests revealed no significant change between the nedocromil sodium and non-nedocromil-treated groups. The percentage of infected bronchioles was quantitated as the number of inflamed airways of 40 bronchioles examined times 100 for each dog. Nedocromil-treated dogs had significantly (p < 0.05) less mucosal inflammation (mean +/- SEM, 39% +/- 5%), epithelial denudation (36% +/- 5%), and BAL neutrophilia (11 +/- 3) than did Sal/CAV2 dogs (51% +/- 6%, 57% +/- 4%, and 33% +/- 8%, respectively). We concluded that pretreatment with nedocromil sodium aerosols attenuated CAV2-induced airway inflammation in these beagle puppies.  (+info)

Canine adenovirus type 2 attachment and internalization: coxsackievirus-adenovirus receptor, alternative receptors, and an RGD-independent pathway. (3/44)

The best-characterized receptors for adenoviruses (Ads) are the coxsackievirus-Ad receptor (CAR) and integrins alpha(v)beta(5) and alpha(v)beta(3), which facilitate entry. The alpha(v) integrins recognize an Arg-Gly-Asp (RGD) motif found in some extracellular matrix proteins and in the penton base in most human Ads. Using a canine adenovirus type 2 (CAV-2) vector, we found that CHO cells that express CAR but not wild-type CHO cells are susceptible to CAV-2 transduction. Cells expressing alpha(M)beta(2) integrins or major histocompatibility complex class I (MHC-I) molecules but which do not express CAR were not transduced. Binding assays showed that CAV-2 attaches to a recombinant soluble form of CAR and that Ad type 5 (Ad5) fiber, penton base, and an anti-CAR antibody partially blocked attachment. Using fluorescently labeled CAV-2 particles, we found that in some cells nonpermissive for transduction, inhibition was at the point of internalization and not attachment. The transduction efficiency of CAV-2, which lacks an RGD motif, surprisingly mimicked that of Ad5 when tested in cells selectively expressing alpha(v)beta(5) and alpha(v)beta(3) integrins. Our results demonstrate that CAV-2 transduction is augmented by CAR and possibly by alpha(v)beta(5), though transduction can be CAR and alpha(v)beta(3/5) independent but is alpha(M)beta(2), MHC-I, and RGD independent, demonstrating a transduction mechanism which is distinct from that of Ad2/5.  (+info)

Preferential transduction of neurons by canine adenovirus vectors and their efficient retrograde transport in vivo. (4/44)

In the central nervous system (CNS), there are innate obstacles to the modification of neurons: their relative low abundance versus glia and oligodendrocytes, the inaccessibility of certain target populations, and the volume one can inject safely. Our aim in this study was to characterize the in vivo efficacy of a novel viral vector derived from a canine adenovirus (CAV-2). Here we show that CAV-2 preferentially transduced i) rat olfactory sensory neurons; ii) rodent CNS neurons in vitro and in vivo; and, more clinically relevant, iii) neurons in organotypic slices of human cortical brain. CAV-2 also showed a high disposition for retrograde axonal transport in vivo. We examined the molecular basis of neuronal targeting by CAV-2 and suggest that due to CAR (coxsackie adenovirus receptor) expression on neuronal cells-and not oligodendrocytes, glia, myofibers, and nasal epithelial cells-CAV-2 vectors transduced neurons preferentially in these diverse tissues.  (+info)

Generation of E3-deleted canine adenoviruses expressing canine parvovirus capsid by homologous recombination in bacteria. (5/44)

E3-deleted canine adenovirus type 1 (CAV-1) was generated by homologous recombination in bacterial cells, using an antibiotic resistance marker to facilitate the recovery of recombinants. This marker was flanked by unique restriction endonuclease sites, which allowed its subsequent removal and the insertion of cassettes expressing the canine parvovirus capsid at the E3 locus. Infectious virus was recovered following transfection of canine cells and capsid expression was observed by RT-PCR from one of the virus constructs. A second construct, containing a different promoter, showed delayed growth and genome instability which, based on the size difference between these inserts, suggests a maximum packaging size of 106 to 109% wild-type genome size for CAV-1.  (+info)

An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropism. (6/44)

Many clinically relevant tissues are refractory to Ad5 transduction because of negligible levels of the primary Ad5 receptor, the coxsackie and adenovirus receptor (CAR). Thus, development of Ad vectors that display CAR-independent tropism could lead directly to therapeutic gain. The Toronto strain of canine adenovirus type 2 (CAV2) exhibits native tropism that is augmented by, but not fully dependent upon, CAR for cellular transduction. We hypothesized that an Ad5 vector containing the nonhuman CAV2 knob would provide expanded tropism and constructed Ad5Luc1-CK, an E1-deleted Ad5 vector encoding the fiber knob domain from CAV2. Ad5Luc1-CK gene delivery to CAR-deficient cells was augmented up to 30-fold versus the Ad5 control vector, and correlated with increased cell surface binding. Further, we confirmed the importance of cellular integrins to Ad5Luc1-CK transduction. Herein, we present the rationale, design, purification, and characterization of a novel tropism modified, infectivity-enhanced Ad vector.  (+info)

Longitudinal study of viruses associated with canine infectious respiratory disease. (7/44)

In this investigation a population of dogs at a rehoming center was monitored over a period of 2 years. Despite regular vaccination of incoming dogs against distemper, canine adenovirus type 2 (CAV-2), and canine parainfluenza virus (CPIV), respiratory disease was endemic. Tissue samples from the respiratory tract as well as paired serum samples were collected for analysis. The development of PCR assays for the detection of CPIV, canine adenovirus types 1 and 2, and canine herpesvirus (CHV) is described. Surprisingly, canine adenovirus was not detected in samples from this population, whereas 19.4% of tracheal and 10.4% of lung samples were positive for CPIV and 12.8% of tracheal and 9.6% of lung samples were positive for CHV. As reported previously, a novel canine respiratory coronavirus (CRCoV) was detected in this population (K. Erles, C. Toomey, H. W. Brooks, and J. Brownlie, Virology 310:216-223, 2003). Infections with CRCoV occurred mostly during the first week of a dog's stay at the kennel, whereas CPIV and CHV were detected at later time points. Furthermore, the evaluation of an enzyme-linked immunosorbent assay for detection of antibodies to CPIV and an immunofluorescence assay for detection of antibodies to CHV is described. This study shows that CPIV is present at kennels despite vaccination. In addition, other agents such as CHV and CRCoV may play a role in the pathogenesis of canine respiratory disease, whereas CAV-2 and canine distemper virus were not present in this population, indicating that their prevalence in the United Kingdom is low due to widespread vaccination of dogs.  (+info)

Cloning and expression of canine interferon-alpha genes in Escherichia coli. (8/44)

We cloned five new subtypes of cDNA encoding canine interferon-alpha (CaIFN-alpha) from a canine epithelial cell line. CaIFN-alphas were divided into two groups by amino acid sequences and a molecular phylogenic tree. Two subtypes of them were expressed in Escherichia coli, and IFN proteins were purified. Recombinant CaIFN-alphas were highly species-specific and showed antiviral activity against Vesicular stomatitis New Jersey virus and canine adenovirus-1 , but not against canine herpesvirus-1.  (+info)

Looking for online definition of canine adenovirus type 2 (CAV-2) in the Medical Dictionary? canine adenovirus type 2 (CAV-2) explanation free. What is canine adenovirus type 2 (CAV-2)? Meaning of canine adenovirus type 2 (CAV-2) medical term. What does canine adenovirus type 2 (CAV-2) mean?
ABSTRACT. Canine adenovirus (CAV) type 1 and 2, respectively, cause infectious canine hepatitis and infectious canine laryngotracheitis in members of the families Canidae and Ursidae worldwide. Both of these infections are acute diseases, especially in young dogs. The aim of this study was to conduct a serological investigation of canine adenovirus infection. For this purpose, serum samples were collected from native pure-bred Kangal (n = 11), and Akbash dogs (n = 17) and Turkish Greyhounds (n = 15) in Eskisehir and Konya provinces. None of the dogs were previously vaccinated against CAV types. Indirect ELISA detected 88.2 %, 93.3 % and 100 % prevalences in Akbash, Greyhound and Kangal dogs, respectively. The remainder of the samples (n = 51) were collected at the Afyonkarahisar Municipality Shelter. Fourty-two of these dogs (82.3 %) were detected as seropositive. In total, 82 of 94 dogs (87.2 %) were found to be positive for CAV serum antibodies.. Keywords: antibody, canine adenovirus, dog, ...
GUR, S e ACAR, A. A retrospective investigation of canine adenovirus (CAV) infection in adult dogs in Turkey. J. S. Afr. Vet. Assoc. [online]. 2009, vol.80, n.2, pp.84-86. ISSN 2224-9435.. Canine adenovirus (CAV) type 1 and 2, respectively, cause infectious canine hepatitis and infectious canine laryngotracheitis in members of the families Canidae and Ursidae worldwide. Both of these infections are acute diseases, especially in young dogs. The aim of this study was to conduct a serological investigation of canine adenovirus infection. For this purpose, serum samples were collected from native pure-bred Kangal (n = 11), and Akbash dogs (n = 17) and Turkish Greyhounds (n = 15) in Eskisehir and Konya provinces. None of the dogs were previously vaccinated against CAV types. Indirect ELISA detected 88.2 %, 93.3 % and 100 % prevalences in Akbash, Greyhound and Kangal dogs, respectively. The remainder of the samples (n = 51) were collected at the Afyonkarahisar Municipality Shelter. Fourty-two of these ...
Adenovirus vectors have significant potential for long- or short-term gene transfer. Preclinical and clinical studies using human derived adenoviruses (HAd) have demonstrated the feasibility of flexible hybrid vector designs, robust expression and induction of protective immunity. However, clinical use of HAd vectors can, under some conditions, be limited by pre-existing vector immunity. Pre-existing humoral and cellular anti-capsid immunity limits the efficacy and duration of transgene expression and is poorly circumvented by injections of larger doses and immuno-suppressing drugs. This review updates canine adenovirus serotype 2 (CAV-2, also known as CAdV-2) biology and gives an overview of the generation of early region 1 (E1)-deleted to helper-dependent (HD) CAV-2 vectors. We also summarize the essential characteristics concerning their interaction with the anti-HAd memory immune responses in humans, the preferential transduction of neurons, and its high level of retrograde axonal transport in the
TY - JOUR. T1 - Nedocromil Sodium Inhibits Canine Adenovirus Bronchiolitis in Beagle Puppies. AU - Anderson, Kurt A.. AU - Lemen, Richard J.. AU - Weger, Natalie S.. AU - Huizhong Chen, Natalie S.. AU - Bowers, Mark C.. AU - Witten, Mark L.. AU - Lantz, R. Clark. AU - Bice, David E.. AU - Muggenburg, Bruce A.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2000/3. Y1 - 2000/3. N2 - Nedocromil sodium is a nonsteroidal anti-inflammatory drug used to control asthmatic attacks. Our hypothesis is that nedocromil sodium inhibits virus-induced airway inflammation, a common trigger of asthma. We nebulized nedocromil sodium into beagle dogs (n = 10, mean ± SEM ages: 149 ± 13 days) before and after inoculation with canine adenovirus type 2 (CAV2). Control dogs (n = 10) received saline aerosols and were either infected with CAV2 (Sa1/CAV2, n = 7, mean ± SEM ages: 140 ± 11 days) or were not infected (Sal/Sal, n = 3, ages: 143 ± 0 days). All dogs were anesthetized with ...
Adenovirus 1 in canines causes respiratory infections, targets a number of organs within the physique, and causes infectious canine hepatitis (ICH), which is a illness that severely impacts the liver ... ...
Canine Adenovirus Pneumonia in 2 puppies- CAV-2 History: Two English Bulldog puppies (1, and 3 weeks old) had trouble breathing in the morning and by noon had died. Gross Necropsy Findings: Lungs: Diffuse dark red to purple, edematous. Histologic Findings: Lungs: Multifocal necrosis of bronchiolar respiratory epithelium and alveolar pneumocytes. Alveolar septa are expanded by…
Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.
Univac 5 dog shot is a modified-live virus for the vaccination of healthy, susceptible dogs and puppies as an aid in the reduction of diseases caused by canine distemper, canine adenovirus types 1 and 2, parainfluenza and parvovirus. Dosage: 1 ml IM or subcut, repeat in 3-4 weeks. Puppies vaccinated before 9 weeks should be revaccinated at
Solo-Jec 9 is a dog vaccine that protects against 9 major diseases: Canine Distemper, Canine Adenovirus Type 1 and Type 2, Parainfluenza, Parvovirus and 4 types of lepto: Leptospira Canicola, Leptospira Grippotyphosa, Leptospira icterohaemorrhagiae and Leptospira Pomona. These are highly fatal if your fur baby isnt vaccinated. Easily protect your puppy yourself with our single dose, or 25-dose tray for litters.
Nobivac Intra-Trac3 ADT is for the prevention of Canine Adenovirus Type 2, Parainfluenza, Bordetella Bronchiseptica Vaccine (MLV). For INTRANASAL use in healthy dogs including pregnant females and healthy puppies.
2 November 2016. Two companies partnering with Auburn University developed a synthetic virus to find and destroy tumor cells in a type of bone cancer in dogs. Financial and intellectual property aspects of the agreement between synthetic gene company Gen9 in Cambridge, Massachusetts, design systems developer Autodesk Inc. in San Rafael, California, and Auburn University College of Veterinary Medicine in Alabama were not disclosed. The research team created a synthetic version of canine adenovirus type 2, or CAV2, a virus usually associated with hepatitis in dogs. In this case, the synthetic CAV-2 virus is designed as an oncolytic virus that finds and attacks cancer cells, while leaving healthy cells and tissue intact. The genome in the organism is believed to be the longest in a functional virus synthesized for cancer research, with about 34,000 base pairs of nucleic acids. The human genome, by comparison, has about 3 billion base pairs. The technology provided by Gen9 in this project makes it possible
BronchiShield - Bronchi-Shield III is a vaccine that prevents diseases caused by Canine Adenovirus Type 1 and Type 2, Parainfluenza, and Bordetella Bronchiseptica. This vaccination includes modified versions of each live virus to help your dogs immune system recognize and resist each virus. It is also easy to dispense as it can be given intranasally. Bronchi-Shield III is recommended for healthy dogs that are at least 8 weeks of age. This package comes with 25 doses of the vaccine to vaccinate multiple dogs and/or to revaccinate dogs annually. Each of the viruses this product aims to prevent can be extremely dangerous to dogs, so order a pack of vaccinations for your dog today! Contains live modified viruses to prevent disease Contains 25 doses of the vaccine for revaccination, etc. Can be dispensed intranasally
Nobivac Intra-Trac 3 25 Dose, Nobivac Canine is for the vaccination of healthy dogs as an aid in prevention of infectious disease associated with canine adenovirus type 2, canine parainfluenza virus,
Hepatitis contagiosa canis (HCC). HCC is caused by the canine adenovirus 1 (CAV-1). The virus is shed in urine and faeces and transmission occurs directly or indirectly. After oronasal infection, the virus first multiplies in the tonsils and subsequently in the endothelium of the blood vessels, in hepatocytes as well as in cornea and uvea. Deposition of immune complexes can result in glomerulonephritis and uveitis with a corneal oedema (blue eye). HCC can be acute or chronic. Especially in unvaccinated puppies, HCC can take a peracute or acute course and can be fatal. Not only dogs, but also all other species of the family Canidae are susceptible to an infection with CAV-1.. Infectious laryngotracheitis. The infectious laryngotracheitis is caused by the canine adenovirus 2 (CAV-2). The virus has a strong affinity to the epithelia of the respiratory tract and is a component of the kennel cough complex. ...
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These vaccines are needed for all puppies and dogs with an unknown vaccine history. These diseases are very serious and cause significant illness and possible death. Vaccines result in very good protection. These CORE VACCINES include Canine Parvovirus, Canine Parainfluenza, Canine Distemper, and Canine Adenovirus (formerly hepatitis). Puppies receive these vaccines at 6-8 weeks, 9-11 weeks, and 12-16 weeks of age. After a booster at one year of age, revaccination is recommended every three years. There are special circumstances that require more or less frequent revaccination. Some vaccines (killed or recombinant) have different schedules.. ...
The URANOTEST Distemper-Adenovirus diagnostic kit is based on the immunochromatographic technique and is designed for the qualitative detection of Canine Adenovirus (CAV) and Distemper virus (CDV) (usually involved in the kennel cough disease) in canine conjunctives.. The test has a double structure; it contains two single tests: a strip for CDV antigen detection and a strip for CAV antigen detection. Each test consists of several overlapped membranes. On one of the membranes, there are a test line (T line) and control line (C line). The lines are not visible before applying the sample. After applying the sample in the appropriate sample well, migration begins by capillarity action through the membrane. If the result is negative, one purple colour band appears in the C area. This line, called control line, always appears, as it is a control line indicating that the test has successfully performed. If the test result is positive, in addition to the control line, a second line will form in the ...
BrainVectors is a network of public and private sector research institutions, which aims devising new gene therapy (GT)-based treatments for Parkinsons disease (PD), by delivering GDNF into the CNS with vectors derived from adeno-associated (AAV), canine adenoviruses (CAV-2) and lentiviruses (LV). Although AAV, CAV-2 and LVV vectors have acceptable bio-safety, their immune response must be better characterized to develop these vectors for clinical use. The possibility to regulate gene expression by inducible promoters represents a significant pharmacological progress of the gene therapy approach for PD. Therefore the work of this consortium will:. ▪ identify inducible gene expression cassettes with increased sensitivity of transactivators and inducers, will reducing the dose of drugs necessary to obtain GDNF expression;. ▪ characterize the immune responses induced by the components of GDNF-AAV, -CAV-2 and -LVV in rodent models for PD by using biomarker-based immunological screening.. The ...
The GROW Research Laboratory aims to bring Gene Therapy to the bedside in India. There are currently no vector generation core facilities even for research uses. Congenital and hereditary genetic diseases are becoming a significant health burden in India, and hence there is a need for adequate and effective genetic testing and counselling services. In Indias urban areas, congenital malformations and genetic disorders are the third most common cause of mortality in newborns. Factors contributing to this high prevalence include consanguineous marriages, high birth rate, improved diagnostic facilities and a lack of expertise in genetic counselling. We are establishing a vector core facility for generating AAV (adeno-associated vector), Adenovirus, Lentivirus and Retrovirus. In future we will further this core into a cGMP facility to generate clinical grade vectors for patient trials.. ...
Gentaur molecular products has all kinds of products like :search , Neuromi \ Recombinant Canine VEGF, 10 ug. \ PR15028-10 for more molecular products just contact us
Indications for Drugs ::. Acne, Mottled hyperpigmentation, Roughness and fine wrinkling of photodamaged skin. Drug Dose ::. Adult: Topical Acne As 0.01-0.1% cream/gel/alcoholic soln: Apply 1-2 times/day. Mottled hyperpigmentation, roughness and fine wrinkling of photodamaged skin As 0.02-0.05% preparation: Apply once daily at night.. Contraindication ::. Hypersensitivity to retinoids. Application to eczematous, sunburnt or abraded skin. Pregnancy, lactation.. Drug Precautions ::. Topical: avoid concomitant topical applications, esp keratolytic agents. Avoid exposure to sunlight, UV light and weather extremes (e.g. cold). Keep away from eyes, mouth, angles of nose, mucous membranes or open wounds. In case of severe local erythema, oedema, blistering or crusting, use less frequently or discontinue. Avoid medicated or drying soaps, abrasive soaps and cleansers, frequent washing and harsh scrubbing. Avoid use of topical preparations with high concentrations of alcohol, menthol, spices or ...
NOTOC__ [[Image:ich01.jpg,thumb,Canine adenovirus 1]] Infectious canine hepatitis (ICH) is a contagious [[viral diseases,viral disease]] of dogs worldwide. ICH is caused by [[canine adenovirus]] type 1, which is antigenically related only to CAV-2 (one of the causes of infectious canine tracheobronchitis, Infectious Tracheobronchitis of Dogs). CAV-1 is resistant to lipid solvents and survives outside the host for weeks or months, but a 1-3% solution of sodium hypochlorite (household bleach) is an effective disinfectant. Ingestion of urine, feces, or saliva of infected dogs is the main route of infection. Recovered dogs shed virus in their urine for ≥6 mo. Initial infection occurs in the tonsillar crypts and Peyers patches, followed by viremia and infection of endothelial cells in many tissues. Liver, kidneys, spleen, and lungs are the main target organs. Chronic kidney lesions and corneal clouding (blue eye) result from immune-complex reactions after recovery from acute or subclinical ...
Infectious canine hepatitis (ICH) is an acute liver infection in dogs caused by Canine mastadenovirus A, formerly called Canine adenovirus 1 (CAV-1). CAV-1 also causes disease in wolves, coyotes, and bears, and encephalitis in foxes.[1] The virus is spread in the feces, urine, blood, saliva, and nasal discharge of infected dogs. It is contracted through the mouth or nose, where it replicates in the tonsils. The virus then infects the liver and kidneys. The incubation period is 4 to 7 days.[2] Symptoms include fever, depression, loss of appetite, coughing, and a tender abdomen. Corneal edema and signs of liver disease, such as jaundice, vomiting, and hepatic encephalopathy, may also occur. Severe cases will develop bleeding disorders, which can cause hematomas to form in the mouth.[1] Death can occur secondary to this or the liver disease. However, most dogs recover after a brief illness, although chronic corneal edema and kidney lesions may persist.[3] Diagnosis is made by recognizing the ...
Dogs & Infectious Canine Hepatitis. Dogs can sometimes become infected with canine hepatitis which is a highly contagious viral disease that occurs most frequently in unvaccinated pups ...
DA2PP is one of the canine core vaccinations, and stands for all the viruses it protects against: canine (D)istemper, canine (A)denovirus type (2), canine (P)arvovirus, and canine (P)arainfluenza. So, what exactly are those viruses?. Canine distemper infects the gastrointestinal and respiratory tracts, as well as the spinal cord and brain. Common symptoms include high fever, eye inflammation and eye/nose discharge, labored breathing and coughing, vomiting and diarrhea, loss of appetite and lethargy, and hardening of nose and footpads. It is very, very contagious, debilitating, and deadly.. Canine adenovirus type 2 is a virus that causes infectious canine hepatitis via the feces, urine, blood, saliva, and nasal discharge of infected dogs. It affects the liver and kidneys.. Canine parvovirus, or parvo, as you may know it, can be very deadly, especially to puppies. Thats why we ask that unvaccinated puppies be held on their owners lap. We have strict cleaning protocols, but all it takes is for ...
Get protection against canine distemper, canine adenovirus type 2, infectious canine hepatitis, and canine parvovirus with Duramune Adult 3.
Univac 9 for the vaccination of healthy dogs as an aid in the prevention of canine distemper, infectious canine hepatitis, respiratory disease caused by canine adenovirus type 2, parainfluenza, parvovirus and lepospirosis infections. Syringe included.
Subcutaneous vaccinationPrevention of disease caused by canine distemper, infectious canine hepatitis, canine adenovirus type 2, canine coronavirus, canine parainfluenza, and canine parovovirusFor healthy dogs over the age of 6 weeks
This information comes from the AMVA and Merck Veterinary Library. Infectious Canine Hepatitis Infectious canine hepatitis (ICH) is a worldwide...
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
Canine hepatitis is an infection that affects that liver and kidneys of dogs and is caused by the adenovirus type 1. Even though this infection affects major organs, the dog may recover and the prognosis is typically good. However, the disease may cause some permanent damage to the kidneys or eyes. Read more: Canine Hepatitis Prognosis
Canine hepatitis is an infection that affects that liver and kidneys of dogs and is caused by the adenovirus type 1. Even though this infection affects major organs, the dog may recover and the prognosis is typically good. However, the disease may cause some permanent damage to the kidneys or eyes. Read more: Canine Hepatitis Prognosis
In 2016 the Chartered Institute of Environmental Health (CIEH) issued the following statement pertinent to vaccination requirements in the Licensing of Animal Boarding Establishments:. An up-to-date veterinary vaccination record must be seen to ensure that dogs boarded have current vaccinations against canine parvovirus, canine distemper, infectious canine hepatitis (adenovirus) and, leptospirosis. The date of the most recent vaccination must be recorded preferably with a valid until date. Sct E5.2 CIEH Model Licence Conditions.. Certification from a veterinary surgeon of a recent protective titre test may be accepted in individual cases as evidence of protection against adenovirus, distemper and parvovirus.. The certificate must state that it is valid for the period of stay at the kennels. The interpretation of individual cases will be undertaken by the responsible person but the (CIEH) statement concludes with the direction:. It is the decision of the kennel proprietor whether to accept ...
EVANSTON, Il. - Weinberg freshman Katie Johnson remains blissfully unaware of the serious deterioration of the health of her dog, Rocky. The 13-year-old Labrador is suffering from infectious canine hepatitis and will probably never get to see the girl who used to take him on walks throughout the neighborhood each day.. Johnson was unavailable for comment on the matter, just like she will be unavailable for her dog, when he needs her the most.. Susan Johnson, Katies mother, seemed saddened by the health state of the beloved family dog, but she made it clear that Katie was too busy at school to spend time worrying about the dog.. Every time I talk to Katie, all she says is how busy she is, Johnson said. I probably shouldnt have let it get this far. She really loves this dog, but Katie told me she just has SO much work this next week.. Katie is currently in one of the library towers browsing on Facebook and BuzzFeed, or just doing anything that is neither studying nor calling her parents to ...
If youre a dog owner, youll want to learn about infectious canine Hepatitis: risk factors, symptoms, diagnosis, treatment, and prevention.
The delivery of vaccination to dogs and cats has undergone fundamental change in the past decade. In response to questions over vaccine safety, guidelines groups have introduced new vaccination schedules that have been accommodated by vaccine manufacturers introducing products with extended duration of immunity (DOI) and products with fewer antigenic components. The newest advance in vaccinology is the availability of simple in-practice test kits that demonstrate whether an individual animal has serological evidence of protection. These test kits can now inform decision making about vaccination in practice.. Correlates of Protection. For canine distemper virus (CDV), canine parvovirus (CPV), canine adenovirus (CAV) and feline parvovirus (FPV), the presence of serum antibody able to neutralize infectious virus and prevent infection and disease provides an extremely strong correlate of protection. Seroprotection is classically measured by the virus neutralization (VN) and haemagglutination ...
ALVES, Christian D.B.T. et al. Identification of enteric viruses circulating in a dog population with low vaccine coverage. Braz. J. Microbiol. [online]. 2018, vol.49, n.4, pp.790-794. ISSN 1517-8382. http://dx.doi.org/10.1016/j.bjm.2018.02.006.. Although the use of vaccines has controlled enteric diseases in dogs in many developed countries, vaccine coverage is still under optimal situation in Brazil. There is a large population of nonimmunized dogs and few studies about the identification of the viruses associated with diarrhea. To address this situation, stool samples from 325 dogs were analyzed by polymerase chain reaction for the detection of common enteric viruses such as Canine adenovirus (CAdV), Canine coronavirus (CCoV), Canine distemper virus (CDV), Canine rotavirus (CRV) and Carnivorous protoparvovirus 1 (canine parvovirus 2; CPV-2). At least one of these species was detected in 56.6% (184/325) of the samples. The viruses detected most frequently in either diarrheic or nondiarrheic ...
While countries with dog control policies have curbed an infectious and gruesome canine cancer, the disease is continuing to lurk in the majority of dog populations around the world, particularly in areas with many free-roaming ...
Sialic-acid-binding immunoglobulin-like lectins (Siglecs) are members of the Ig superfamily that bind sialic acids in different linkages in a wide variety of glycoconjugates. These membrane receptors are expressed in a highly specific manner, predominantly within the haematopoietic system. The CD33- …
Vaccines that protect your dog from diseses such as Rabies, Distemper, Adenovirus, Parvovirus, Parainfluenza, Coronavirus, Canine Hepatitis and Kennel Cough.
Therefore, if we want to change the behavior of a dog -- make it more peaceful and less vital -- we must also change its shape. Herein lies the dilemma for the breeder. The audience wants household dogs that are a historical representation of the working-breed shapes, and at the same time they do not want them to display working-breed behaviors. Trying to select for an acceptable household behavior while holding the working shape constant cannot be done. The dog will come apart. It will show genetic diseases. Its hips wont fit together right. The joints will show weaknesses, and the dog will twitch and bleed and each generation will become increasingly miserable ...
To bring pets on the island you need to show proof of vaccinations and health papers. Animals must be accompanied by a certificate of freedom from infection/contagious disease by a veterinarian following examination not more than 48 hours prior to shipment; animals must also be certified as having been vaccinated against rabies not less than one month nor more than six months prior to departure; and must be free of open wounds. Dogs must have a valid certification of vaccination against distemper, parvovirus, infectious canine hepatitis and leptospirosis. Animals may be required to be re-vaccinated against rabies on arrival if certifications are deemed unsatisfactory ...
Mastadenovirus is a genus of viruses, in the family Adenoviridae. Human, mammals, and vertebrates serve as natural hosts. There are currently 25 species in this genus, including the type species Human mastadenovirus C. Diseases associated with this genus include: very common human infection, estimated to be responsible for between 2% and 5% of all respiratory infections. usually mild respiratory, gastrointestinal and eye infections. serotypes 3, 5 and 7: lower respiratory tract infections. serotypes 8, 19, and 37: epidemic keratoconjunctivitis. serotypes 4 and 7: acute respiratory disease. serotypes 40 and 41: gastroenteritis. serotype 14: can cause potentially fatal adenovirus infections. Canine adenovirus 1 (CAdV-1) can lead to death in puppies, or encephalitis in other carnivore species. Group: dsDNA Order: Unassigned Family: Adenoviridae Genus: Mastadenovirus Bat mastadenovirus A Bat mastadenovirus B Bovine mastadenovirus A Bovine mastadenovirus B Bovine mastadenovirus C Canine ...
In general terms, inflammation in the lungs is the response of tissues or cells to injury, irritation, or infection.. More specifically, most cases of pneumonia in dogs are caused by a bacterial infection. The most common bacteria that cause pneumonia in dogs are Bordetella bronchiseptica, Streptococcus zooepidemicus, Pasteurella multocida, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Mycoplasma species.. B. bronchiseptica is highly contagious and may spread easily to other dogs. It usually causes kennel cough, an infection of the trachea and bronchi, but can spread deeper into the lungs, especially in young or old dogs, or dogs with a compromised immune system. Most other causes of bacterial pneumonia are not particularly contagious to other dogs.. Sometimes, dogs develop bacterial pneumonia as a secondary infection. In some of these cases, the primary or underlying cause is a viral infection such as influenza, parainfluenza, or canine adenovirus type-2. In other ...
Kennel Cough Well its that time of year when we are all thinking about summer holidays. As a dog owner we have to make decisions - to take our dog with us, or not… The Vital Pet Health Vets have put this professional document together to advise you about the specifics of Kennel Cough. Kennel cough or Infectious Canine Tracheobronchitis, is […]. ...
Infectious canine tracheobronchitis, also referred to as kennel cough, is an extremely contagious respiratory disease that affects dogs, according to PetMD. The most common causes of kennel cough in...
Canine hepatitis is an infectious disease. This disease is found in dogs, wolves, coyotes, foxes, and in bears. This virus directly attacks on the kidney and liver of the animal. The word hepatitis is originated from the Greek word, which means the inflammation of the liver, caused by the infectious toxic. This disease is very Read more ...
Canine hepatitis is an infectious disease. This disease is found in dogs, wolves, coyotes, foxes, and in bears. This virus directly attacks on the kidney and liver of the animal. The word hepatitis is originated from the Greek word, which means the inflammation of the liver, caused by the infectious toxic. This disease is very Read more ...
Hello. My partner and I will in the next few months adopt a new puppy (as soon as we move to a new house with a garden). Right now we have a small...
D for canine distemper, A2 for canine adenovirus type 2, which offers cross-protection to canine adenovirus type 1 (the more ... DA2PPC also protects against the more virulent strain, adenovirus Type 1 (see canine adenovirus). Type 1 adenovirus, also ... see Canine adenovirus), the first P for canine parvovirus, and the second P for parainfluenza. Because infectious canine ... "Adenovirus 1 in Dogs". www.petmd.com. Retrieved 2019-12-09. "Canine parvovirus". American Veterinary Medical Association. ...
Canine adenovirus 2 (CAdV-2) is one of the potential causes of kennel cough. Core vaccines for dogs include attenuated live ... Two types of canine adenoviruses are well known, type 1 and 2. Type 1 (CAdV-1) causes infectious canine hepatitis, a ... Adenoviruses Stanford University-Adenoviruses Adenoviruses General Concepts General information on Adenovirus DNA virus ... Tupaia adenovirus (TAV) (tree shrew adenovirus 1) has been isolated from tree shrews. Otarine adenovirus 1 has been isolated ...
Genomic analysis suggests canine adenoviruses may have originated from bites by vespertilionid bats. Adenovirus genome Davison ... Bat adenovirus TJM genome European Nucleotide Archive: Bat adenovirus TJM Stanford University - Adenoviruses 3D macromolecular ... published the isolation and the whole genome sequence of a third bat adenovirus (BtAdV-3, proposed species Bat adenovirus A). " ... Bat adenovirus B and Murine adenovirus B, in the genus Mastadenovirus, family Adenoviridae" (PDF). International Committee on ...
serotype 14: can cause potentially fatal adenovirus infections. Canine adenovirus 1 (CAdV-1) can lead to death in puppies, or ... Bat mastadenovirus A Bat mastadenovirus B Bovine mastadenovirus A Bovine mastadenovirus B Bovine mastadenovirus C Canine ...
Canine distemper virus is closely related to measles virus and is the most important viral disease of dogs. The disease (which ... Many other viruses, including caliciviruses, herpesviruses, adenoviruses and parvoviruses, circulate in marine mammal ... Companion animals such as cats, dogs, and horses, if not vaccinated, can catch serious viral infections. Canine parvovirus 2 is ... The infection resembled canine distemper; the animals died within two weeks of respiratory distress and many aborted pups were ...
Kennel cough can also be caused by canine adenovirus-2 or canine parainfluenza virus or a combination of pathogens. In rabbits ... It is a serious disease of dogs, pigs, and rabbits, and has been seen in cats, horses, and seals. A PCR test for the pathogen ... It can cause infectious bronchitis in dogs and other animals, but rarely infects humans. Closely related to B. pertussis-the ... CS1 maint: discouraged parameter (link) Wagener, J. S., R. Sobonya, L. Minnich and L. M. Taussig (1984). Role of canine ...
Mice and dogs with MPS I have been successfully treated with gene therapy. Most vectors can correct the disease in the liver ... In animal models, delivery of the iduronidase gene has been accomplished with retrovirus, adenovirus, adeno-associated virus, ...
... s can carry diseases such as rabies, canine parvovirus, canine distemper, canine adenovirus, Ehrlichia canis ... Juliane Kaminski & Sarah Marshall-Pescini (2014). "Chapter 1 - The Social Dog:History and Evolution". The Social Dog:Behavior ... In the western Cape in the early 20th century, dogs bred by crossing foxhounds, lurchers, and borzoi were used. Spring traps ... The black-backed jackal (Lupulella mesomelas) is a medium sized canine native to eastern and southern Africa. These regions are ...
Canine adenovirus 2 (CAdV-2) is one of the potential causes of kennel cough. Core vaccines for dogs include attenuated live ... Two types of canine adenoviruses are well known, type 1 and 2. Type 1 (CAdV-1) causes infectious canine hepatitis, a ... Adenoviruses are also known to cause respiratory infections in horses, cattle, pigs, sheep, and goats. Equine adenovirus 1 can ... Main article: Adenovirus vaccine. In the past, US military recruits were vaccinated against two serotypes of adenovirus, with a ...
Other canine vaccines include canine distemper, canine parvovirus, infectious canine hepatitis, adenovirus-2, leptospirosis, ... Not all toxoids are for micro-organisms; for example, Crotalus atrox toxoid is used to vaccinate dogs against rattlesnake bites ... Where rabies occurs, rabies vaccination of dogs may be required by law. ... Bordetella, canine parainfluenza virus, and Lyme disease, among others. Cases of veterinary vaccines used in humans have been ...
Other causes of retinal dysplasia in dogs include infection with canine adenovirus or canine herpesvirus, or radiation of the ... Most cases of retinal dysplasia in dogs are hereditary. It can involve one or both retinas. Retinal dysplasia can be focal, ...
... respiratory syncytial virus and adenoviruses. The name bocavirus is derived from bovine and canine, referring to the two known ... Schwartz D, Green B, Carmichael LE, Parrish CR (October 2002). "The canine minute virus (minute virus of canines) is a distinct ... and minute virus of canines which infects dogs. Parvoviruses (Latin: small viruses) have a 5 kilobase long single-stranded DNA ... Phylogenetic analysis of swine bocavirus places it with canine minute virus. Incomplete sequences of bocaviruses have been ...
Several intranasal vaccines have been developed that contain canine adenovirus in addition to B. bronchiseptica and canine ... without complications from canine distemper virus (CDV) or canine adenovirus (CAV). This form occurs most regularly in autumn, ... Prevention is by vaccinating for canine adenovirus, distemper, parainfluenza, and Bordetella. In kennels, the best prevention ... Kennel cough, also known as canine infectious respiratory disease, formerly canine infectious tracheobronchitis, is an upper ...
... adenoviruses, canine MeSH B04.280.030.500.350 - adenoviruses, human MeSH B04.280.030.500.675 - adenoviruses, porcine MeSH ... adenoviruses, canine MeSH B04.909.204.097.500.350 - adenoviruses, human MeSH B04.909.204.097.500.675 - adenoviruses, porcine ... canine MeSH B04.820.455.600.650.500.320 - distemper virus, phocine MeSH B04.820.455.600.650.500.500 - measles virus MeSH ... canine MeSH B04.820.504.540.150.190 - coronavirus, feline MeSH B04.820.504.540.150.210 - coronavirus 229e, human MeSH B04.820. ...
... and viral infections such as Canine parvovirus or adenovirus. If the puppy is unable to nurse independently, supplemental ... It is also associated with the parasite Toxocara canis and the viruses Canine herpesvirus and Canine parvovirus. In 2012, Tony ... Like other species of mammals, canine puppies are very vulnerable during their first weeks of life, partly because they have no ... Dog Breeding, Whelping and Puppy Care. John Wiley & Sons. p. 297. ISBN 9781118414354. "Caring for new puppies, PetAssure". " ...
One study searched for viral DNA from canine herpesvirus, canine adenovirus, and canine parvovirus in brain tissue from dogs ... "Necrotizing meningoencephalitis of Pug Dogs associates with dog leukocyte antigen class II and resembles acute variant forms of ... The disease is more common in female dogs of young and middle age. It has a rapid onset. The lesions of GME exist mainly in the ... GME is likely second only to encephalitis caused by canine distemper virus as the most common cause of inflammatory disease of ...
... is an acute liver infection in dogs caused by Canine mastadenovirus A, formerly called Canine adenovirus 1 (CAV-1). CAV-1 also ... Most combination vaccines for dogs contain a modified canine adenovirus type-2.[4] CAV-2 is one of the causes of respiratory ... "Infectious Canine Hepatitis: Introduction". The Merck Veterinary Manual. 2006. Retrieved 2007-01-28.. ... Most dogs recover spontaneously without treatment. Prevention is through vaccination (ATCvet code QI07AA05 (WHO) and various ...
... canine parainfluenza virus QI07AD05 Canine distemper virus QI07AD06 Canine distemper virus + canine adenovirus QI07AD07 Canine ... live canine adenovirus + inactivated leptospira QI07AI02 Live canine distemper virus + live canine adenovirus + live canine ... canine reovirus + canine influenza virus QI07AA04 Canine parainfluenza virus QI07AA05 Canine adenovirus QI07AA06 Canine ... canine adenovirus + canine parvovirus QI07AD03 Canine distemper virus + canine parvovirus QI07AD04 Canine distemper virus + ...
... adenovirus infections, human MeSH C02.256.076.381 - hepatitis, infectious canine MeSH C02.256.430.400 - hepatitis b MeSH ...
... canine adenovirus, protozoan Toxoplasma gondii, bacterium Leptospira interrogans, and nematode Dirofilaria immitis. The maned ... It is the only species in the genus Chrysocyon (meaning "golden dog"). It is the largest canine in South America, weighing 20- ... and it has a more distant relationship to other South American canines (the short-eared dog, the crab-eating fox, and the ... Feral and domestic dogs pass on diseases to them, and have been known to attack them. The species occurs in several protected ...
... canine distemper) CAV-2 (canine hepatitis virus or adenovirus-2) Canine herpesvirus Canine influenza CPV-2 (canine parvovirus) ... Aging in dogs Canine hydrotherapy Dog anatomy Dog odor Hypoallergenic dog food Senior dog diets Shaw, SE; Day, MJ; Birtles, RJ ... canine parvovirus, canine distemper, and infectious canine hepatitis (using canine adenovirus type 2 to avoid reaction). The ... Eye diseases are common in dogs. Cataracts, canine glaucoma, and entropion are seen in dogs. Canine-specific eye diseases ...
Generally not recommended, owing to unproven efficacy, are vaccines for: canine coronavirus, canine adenovirus-1 (which also ... canine hepatitis virus or adenovirus-2) and CPV-2 (canine parvovirus). This combination vaccine may also be known as DHPP or ... Vaccination of dogs is the practice of animal vaccination applied to dogs. Programs in this field have contributed both to the ... "2011 AAHA Canine Vaccination Guidelines" (PDF). American Animal Hospital Association (AAHA) Canine Vaccination Task Force. 2011 ...
... canine adenovirus, protozoan Toxoplasma gondii, bacterium Leptospira interrogans, and nematode Dirofilaria immitis.[35][34] The ... and it has a more distant relationship to other South American canines (the short-eared dog, the crab-eating fox, and the ... The maned wolf (Chrysocyon brachyurus) is a large canine of South America.[4] Its markings resemble those of foxes, but it is ... The maned wolf's rhinarium extends to the upper lip, similar to the bush dog, but its vibrissae are longer.[13] The skull also ...
... canine herpesvirus, canine coronavirus and canine adenovirus. The wolf was the template of numerous Ancient Egyptian deities, ... It often eats alongside African wild dogs, and will stand its ground if the dogs try to harass it. Encounters with Ethiopian ... being able to expose its canine teeth like a dog. The vocabulary of the African golden wolf is similar to that of the domestic ... The African golden wolf (Canis lupaster) or African wolf is a canine native to North Africa, West Africa, the Sahel, northern ...
"Gene therapy restores vision in a canine model of childhood blindness". Nature Genetics. 28 (1): 92-95. doi:10.1038/ng0501-92. ... Bennett started by investigating adenoviruses and adeno-associated viruses (AAV) for gene editing in mice and non-human ... forward and demonstrated that AAV-mediated delivery of a functional RPE65 gene significantly improved sight in near-blind dogs ...
Dog har nye genetiske undersøgelser ændret på denne opfattelse, da det har vist sig at virus nedstammer fra en fælles stamform ... Model af adenovirus-kapsid, prototypen på et kapsid af en dsDNA-virus ... Dog kan nært beslægtede vira (efter Baltimore-klassifikationen) inficere forskellige værter. 2/3 af alle kendte vira inficerer ...
... he probably saved the life of a person who had been bitten by a clearly rabid dog by performing the same inactivating process ...
... including canine distemper, canine parvovirus, infectious canine hepatitis, adenovirus-2, leptospirosis, bordatella, canine ... Where rabies occurs, laws may require dogs to get rabies vaccinations. Dogs can also be vaccinated against many other diseases ...
Weese, JS (2011 Mar). "Bacterial enteritis in dogs and cats: diagnosis, therapy, and zoonotic potential". The Veterinary ... Gastroenteritis viruses: A = rotavirus, B = adenovirus, C = Norovirus and D = Astrovirus. The virus particles are shown at the ...
... oral adenovirus type 4 and type 7 vaccine, in U.S. Military recruits". Vaccine. 31 (28): 2963-2971. doi:10.1016/j.vaccine. ... "Evaluation of an attenuated strain of Ehrlichia canis as a vaccine for canine monocytic ehrlichiosis". Vaccine. 31 (1): 226-233 ... Adenovirus Vaccine Efficacy Trial Consortium (2013). "A phase 3, randomized, double-blind, placebo-controlled study of the ...
Canine distemper virus (CDV) is known to cause apoptosis in central nervous system and lymphoid tissue of infected dogs in vivo ... The adenovirus E1B-55K protein and the hepatitis B virus HBx protein are examples of viral proteins that can perform such a ... Examples of viral Bcl-2 proteins include the Epstein-Barr virus BHRF1 protein and the adenovirus E1B 19K protein.[104] Some ... This is an important oncolytic property of CDV: this virus is capable of killing canine lymphoma cells. Oncoproteins E6 and E7 ...
... canine parvovirus is still able to infect cats. The canine parvovirus has the tradeoff of gaining the ability to infect canine ... which only work with a helper virus such as adenovirus. Other viruses that can infect without helper viruses are called as ... Canine and feline[edit]. Canine parvovirus is a mutant strain of feline parvovirus.[10][11][12] A very specific mutation is ... Thus, all isolates of canine parvovirus affect dogs, wolves, and foxes, but only some of them will infect cats. ...
However a member of this genus has been discovered in dogs: canine hepacivirus.[5] There is also at least one virus in this ... Adenovirus Adenovirus infection. RNA virus. Rotavirus. Norovirus. Astrovirus. Coronavirus. Hepatitis. DNA virus. HBV (B). RNA ... "Characterization of a canine homolog of hepatitis C virus". Proc Natl Acad Sci U S A. 108 (28): 11608-13. Bibcode:2011PNAS.. ...
Mange lidt forskellige adenovirus kan forårsage forkølelse.[10] Nukleinsyre-vacciner[redigér , redigér wikikode]. RNA-vaccine[ ... men den er dog kemisk modificeret, hvilket betyder, at den ikke kan forårsage sygdom. Ofte anvendes beta-propiolacton, et ... Johnson COVID-19 vaccinerne bruger forskellige adenovirus som leveringssystem. ...
en svækket Adenovirus - sådan en vaccine kaldes en vektor-vaccine. Lipidnanopartikler[redigér , redigér wikikode]. ... mRNA-vacciner skal dog stadig transporteres og opbevares ved meget lave temperaturer.[3] ...
Several domestic species have been infected with and shown symptoms of H5N1 viral infection, including cats, dogs, ferrets, ... Adenovirus Adenovirus infection. RNA virus. Rotavirus. Norovirus. Astrovirus. Coronavirus. Hepatitis. DNA virus. HBV (B). RNA ... dog flu, horse flu and human flu as an illness caused by strains of influenza viruses that have adapted to a specific host. Out ...
"Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization". J. Virol. 80 (4 ...
I: dsDNA viruses (e.g. Adenoviruses, Herpesviruses, Poxviruses). *II: ssDNA viruses (+ strand or "sense") DNA (e.g. ... Canine parvovirus is caused by a small DNA virus and infections are often fatal in pups.[210] Like all invertebrates, the honey ... Viral genomes are circular, as in the polyomaviruses, or linear, as in the adenoviruses. The type of nucleic acid is irrelevant ... Carmichael L. An annotated historical account of canine parvovirus. Journal of veterinary medicine. B, Infectious diseases and ...
ingestion of material contaminated with infected dog or cat feces (humans: dead-end host) ... Adenovirus Adenovirus infection. RNA virus. Rotavirus. Norovirus. Astrovirus. Coronavirus. Hepatitis. DNA virus. HBV (B). RNA ...
Other canine vaccines include canine distemper, canine parvovirus, infectious canine hepatitis, adenovirus-2, leptospirosis, ... See also: Influenza vaccine § Flu vaccine for nonhumans, and Vaccination of dogs ... Where rabies occurs, rabies vaccination of dogs may be required by law. ... bordatella, canine parainfluenza virus, and Lyme disease, among others. Cases of veterinary vaccines used in humans have been ...
E19 from some adenoviruses block the movement of MHC I to the proper locations for the endogenous pathway. ... The complex has been compared to a "hot dog in a bun".[citation needed] ...
... vacinas baseadas en adenovirus, e vacinas baseadas no VSIV están xa na fase de ensaio clínico.[98][99][100][101] ... "Ebola virus antibody prevalence in dogs and human risk". Emerging Infect. Dis. 11 (3): 385-90. PMC 3298261. PMID 15757552. doi ... É outro fármaco antiviral de amplo espectro, inicialmente pensado para tratar infeccións por citomegalovirus e adenovirus, que ... ou vacinas derivadas de adenovirus,[93] virus da estomatite vesicular Indiana (VSIV)[94][95][96] ou partículas tipo filovirus ( ...
Liu, H.; Jin, L.; Koh, S. B. S.; Atanasov, I.; Schein, S.; Wu, L.; Zhou, Z. H. (2010). "Atomic Structure of Human Adenovirus by ... Large dog[نیازمند منبع] ۱۰۲ 125-180 kg Mature شیر (گربه‌سان), female (125 kg) and male (180 kg)[نیازمند منبع] ...
Rotavirus, norovirus, adenovirus, and astrovirus are known to cause viral gastroenteritis.[18][26] Rotavirus is the most common ... Many of the same agents cause gastroenteritis in cats and dogs as in humans. The most common organisms are Campylobacter, ... Weese, JS (March 2011). "Bacterial enteritis in dogs and cats: diagnosis, therapy, and zoonotic potential". Veterinary Clinics ... Gastroenteritis viruses: A = rotavirus, B = adenovirus, C = norovirus and D = astrovirus. The virus particles are shown at the ...
Human parvovirus B19, canine parvovirus Naked Icosahedral ss II 4. Herpesviridae Herpes simplex virus, varicella-zoster virus, ... I: dsDNA viruses (e.g. Adenoviruses, Herpesviruses, Poxviruses). *II: ssDNA viruses (+ strand or "sense") DNA (e.g. ... Measles virus, mumps virus, respiratory syncytial virus, Rinderpest virus, canine distemper virus Enveloped Helical ss(-) V ... Canine hepatitis virus, Some types of the common cold Naked Icosahedral ds I ...
It differs in dogs, horses, and ruminants. In dogs a single duct connects the nasopharynx to the nasal cavity. The tonsils are ... Adenovirus infection. آران‌ای ویروس. روتاویروس. Norovirus. Astrovirus. کروناویروس. Hepatitis. دی‌ان‌ای ویروس. HBV (B). آران‌ای ...
... dog, cow, mouse, rat, chicken, zebrafish, and frog.[11] KLF4 was first identified in 1996.[12] ... "Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of ... "Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of ...
These dog-specific SINEs may code for a splice acceptor site, altering the sequences that appear as exons or introns in each ... and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377-88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281. ... Canines differ primarily in their abundance of SINEC_Cf repeats throughout the genome, rather than other gene or allele level ... Wang W, Kirkness EF (December 2005). "Short interspersed elements (SINEs) are a major source of canine genomic diversity". ...
Bowman L (4 December 2004). "Study on dogs yields hope in human paralysis treatment". seattlepi.com. Ma, Yufei; Ji, Yuan; Zhong ... Kreppel F, Kochanek S (January 2008). "Modification of adenovirus gene transfer vectors with synthetic polymers: a scientific ...
Two types of Canine Adenovirus (CAVs), Canine Adenovirus type 1 (CAV-1), the virus which causes infectious canine hepatitis, ... Two types of Canine adenovirus (CAVs), Canine Adenovirus type 1 (CAV-1), the virus which causes infectious canine hepatitis, ... Despite the frequent occurrence of Canine Adenovirus worldwide, in Turkey, the only notified cases of Canine Adenovirus (CAV) ... canine distemper virus, and canine adenovirus type-1 in adult household dogs," Canadian Veterinary Journal, vol. 52, no. 9, pp ...
This review updates canine adenovirus serotype 2 (CAV-2, also known as CAdV-2) biology and gives an overview of the generation ... Preclinical and clinical studies using human derived adenoviruses (HAd) have demonstrated the feasibility of flexible hybrid ... Adenovirus vectors have significant potential for long- or short-term gene transfer. ... This review updates canine adenovirus serotype 2 (CAV-2, also known as CAdV-2) biology and gives an overview of the generation ...
... is one of the reasons dogs get kennel cough, a contagious disease. Common symptoms include coughing and gagging accompanied by ... Canine adenovirus type 2 causes respiratory disease in dogs and is one of the infectious agents commonly associated with canine ... Along with Bordetella and parainfluenza, canine adenovirus type 2 (CAV-2) is one of the reasons dogs get kennel cough. Coughing ... The CAV-2 vaccine also protects against infection with canine adenovirus type 1 (CAV-1). CAV-1 causes infectious canine ...
Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL)). ... Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL)) ... sp,Q65955,CAPSH_ADECC Hexon protein OS=Canine adenovirus serotype 1 (strain CLL) OX=69150 GN=L3 PE=3 SV=1 ... IPR016108, Adenovirus_Pll_hexon_C. IPR016107, Adenovirus_Pll_hexon_N. IPR037542, ADV_hexon. IPR016111, Hexon_subdom4. ...
... and causes infectious canine hepatitis (ICH) -- a disease that severely affects the liver and can be fatal in as many as 30 ... Adenovirus 1 in dogs is a virus that causes respiratory infections, targets multiple organs in the body, ... percent of the dogs who suffer from it. Heres what you should know. ... Because the virus is contagious from dog to dog, it appears more often where groups of dogs are usually together, such as dog ...
Helper-dependent adenovirus vectors (HDVs) are safe and efficient tools for gene transfer with high cloning capacity. However, ... Canine adenovirus (Ad) type 2 vectors, holding attractive features to overcome immunogenic concerns and treat neurobiological ... Helper-dependent adenovirus vectors (HDVs) are safe and efficient tools for gene transfer with high cloning capacity. However, ...
Three-Dimensional Structure of Canine Adenovirus Serotype 2 Capsid. Guy Schoehn, Majida El Bakkouri, Céline M. S. Fabry, Oliver ... Three-Dimensional Structure of Canine Adenovirus Serotype 2 Capsid. Guy Schoehn, Majida El Bakkouri, Céline M. S. Fabry, Oliver ... Three-Dimensional Structure of Canine Adenovirus Serotype 2 Capsid. Guy Schoehn, Majida El Bakkouri, Céline M. S. Fabry, Oliver ... Three-Dimensional Structure of Canine Adenovirus Serotype 2 Capsid Message Subject (Your Name) has forwarded a page to you from ...
Emery J B, House J A, Brown W R 1978 Cross-protective immunity to canine adeno-virus type-2 by canine adenovirus type-1 ... Canine adenovirus (CAV) type 1 and 2, respectively, cause infectious canine hepatitis and infectious canine laryngotracheitis ... 1. Appel M J 1987 Canine adenovirus type 1 (infectious canine hepatitis virus). In Horzinek M C (ed.) Virus infections of ... immunosorbent assay for the detection of canine antibodies to canine adenoviruses. Laboratory Animal Science 29: 603-609 [ ...
What is canine adenovirus type 2 (CAV-2)? Meaning of canine adenovirus type 2 (CAV-2) medical term. What does canine adenovirus ... Looking for online definition of canine adenovirus type 2 (CAV-2) in the Medical Dictionary? canine adenovirus type 2 (CAV-2) ... adenovirus. (redirected from canine adenovirus type 2 (CAV-2)). Also found in: Dictionary, Thesaurus, Encyclopedia. adenovirus ... Canine adenovirus type 2 (CAV-2) , definition of canine adenovirus type 2 (CAV-2) by Medical dictionary https://medical- ...
Find details on Canine adenovirus type 2 in dogs including diagnosis and symptoms, active forms, resting forms, clinical ... Vaccines against infectious canine hepatitis have been developed as an alternative to canine adenovirus type 1 vaccines. (Do ... canine parainfluenzavirus 2 Canine parainfluenza virus 2 , canine distemper virus Canine distemper virus and Bordetella ... Live attenuated canine adenovirus 2 vaccines protect against CAV1 and CAV2.. *Vaccinate at 12 weeks of age (plus 9 weeks if at ...
Contrasting Effects of Human, Canine, and Hybrid Adenovirus Vectors on the Phenotypical and Functional Maturation of Human ... Contrasting Effects of Human, Canine, and Hybrid Adenovirus Vectors on the Phenotypical and Functional Maturation of Human ... Contrasting Effects of Human, Canine, and Hybrid Adenovirus Vectors on the Phenotypical and Functional Maturation of Human ... Contrasting Effects of Human, Canine, and Hybrid Adenovirus Vectors on the Phenotypical and Functional Maturation of Human ...
Adenovirus Type-I & Influenza in dogs Time to expiry: Jan 2019 Ideal for Vets but also suitable for home testing as each pack ... Canine) Tests / Canine (Dog) Distemper Test / 10 x Dog Test Triple - Adenovirus Type-1, Distemper & Influenza - Canine Swab ... Dog (Canine) Tests, Canine (Dog) Distemper Test, Canine Adenovirus & Parainfluenza Tests ... What is Canine Adenovirus Type-1?. Adenovirus 1 is the more severe version of the two kinds of adenovirus known to cause ...
Canine helper-dependent vectors production: implications of Cre activity and co-infection on adenovirus propagation. ... Canine helper-dependent vectors production: implications of Cre activity and co-infection on adenovirus propagation. Fernandes ... relation to adenovirus amplification/HV contamination were evaluated to develop a production protocol for HD canine adenovirus ... Here, we show how Cre and MOI ratio impact adenovirus vectors yields and infectivity, providing key-information to design an ...
Glomerulonephritis associated with simultaneous canine adenovirus-1 and Dirofilaria immitis infection in a dog. ... Glomerulonephritis associated with simultaneous canine adenovirus-1 and Dirofilaria immitis infection in a dog. J Vet Med B ... Adenoviridae Infections, Animals, Dirofilariasis, Dog Diseases, Dogs, Glomerulonephritis, Hepatitis, Viral, Animal, ... deposition in the mesangium and basement membranes of a 2-year-old dog with canine viral hepatitis and dirofilariasis. The ...
Skeletal muscle collection includes over 185 mAbs against myosin isoforms for myofiber typing, MyoD and myogenin TFs, and Troponin complex I and T
About the Journal. Polar Research is the peer-reviewed journal of the Norwegian Polar Institute, Norways central institution for research, environmental monitoring and mapping of the polar regions. Promoting the global exchange of scientific knowledge about the Arctic and Antarctic across disciplinary boundaries, Polar Research was the first all open access polar journal. The journal has been awarded the DOAJ Seal by the Directory of Open Access Journals for its openness and high publishing standards. From the first issue in 1982 to the current volume, all articles are available to readers free of charge. APCs are comparatively low.. ...
Adenovirus on Flipboard. Explore COVID-19 Vaccines, Rabies, Latin America and more. ... Should I Get My Dog Vaccinated?. thedodo.com - Sam Howell. If you just got a new dog, youre probably wondering which vaccines ...
... as those that protect from canine distemper virus (CDV), canine adenovirus (CAV) and canine parvovirus type 2 (CPV2)… ... Long-lived immunity to canine core vaccine antigens in UK dogs as assessed by an in-practice test kit 25th April 2018. /in ... The WSAVA and AAHA have defined canine core vaccines, i.e. those that all dogs regardless of circumstances or geographical ... 16Long-lived immunity to canine core vaccine antigens in UK dogs as assessed by an in-practice test kit. ...
Canine adenovirus type 2 (CAV-2). Test code: S0103 - Ultrasensitive qualitative detection of canine adenovirus type 2 by real ... Two adenoviruses have been identified in the dog: canine adenovirus type 1 (CAV-1) which infects most of the major organs ... Top dogs can catch things too! Our NEW dog show panel checks for 8 pathogens potentially transmissible at dog shows. ... Oh baby! Try our canine breeding PCR panel - 3 canine sexually transmitted diseases tested from swabs or semen samples.. ...
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Explore our range of Canine Adenovirus 1 and Canine Adenovius 2 antigens, supporting all of your research and assay development ... Canine Adenovirus. Canine adenovirus type 1 (Canine mastadenovirus A) is the causative agent of infectious canine hepatitis ( ... Canine adenovirus type 2 is related to canine adenovirus type 1 and used in vaccines to provide protection against canine ... Both canine adenovirus (CAdV-1) and canine adenovirus 2 (CAdV-2) are spread similarly, but the resulting diseases are vastly ...
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Adenovirus Type 2 This virus causes a form of kennel cough and also protects against hepatitis in dogs. This is fortunate ... House dogs that dont have much contact with other dogs dont have a high risk of exposure. Dogs that attend shows or sporting ... basically prior to boarding or for dogs that go to lots of shows or other events where there are other dogs. When a dog reacts ... We live in a very rural community and we dont have dog parks or limited areas that lots of dogs play in --- we have mostly ...
... animal-protein free medium designed and optimized to support high-density culture of Madin Darby Canine Kidney (MDCK) cells. ... Figure 6. Canine Adenovirus Production in EX-CELL MDCK. EX-CELL MDCK supported the production of CAV in MDCK cells adapted to ... Canine Adenovirus Production. To determine the capability of EX-CELL MDCK to support the production of virus, MDCK cells were ... MDCK cells in EX-CELL MDCK were also infected with Canine Adenovirus (CAV) and produced 107.5 TCID50/mL at a multiplicity of ...
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Canine Adenovirus Pneumonia in 2 puppies- CAV-2 History: Two English Bulldog puppies (1, and 3 weeks old) had trouble breathing ... The features of the pneumonia are diagnostic for Canine Adenovirus type 2. This disease affects unvaccinated juvenile dogs and ... Canine Adenovirus Pneumonia in 2 puppies- CAV-2. Posted on October 27, 2011 by Brian ... Canine Adenovirus Pneumonia in 2 puppies- CAV-2. History: Two English Bulldog puppies (1, and 3 weeks old) had trouble ...
DOG - OVER 6 WEEKS OLD - CANINE ADENOVIRUS - TYPE 1 , CANINE ADENOVIRUS - TYPE 2 , CANINE DISTEMPER , CANINE PARAINFLUENZA , ... ADENOVIRUS, PARVOVIRUS AND PARAINFLUENZA VIRUS LIVE VACCINE - IMMUNOTHERAPY - ... CANINE ADENOVIRUS - TYPE 1 , CANINE ADENOVIRUS - TYPE 2 , CANINE DISTEMPER , CANINE PARAINFLUENZA , CANINE PARVOVIRUS , ... CANINE DISTEMPER , HEPATITIS CANINE = CANINE ADENOVIRUS , CANINE PARAINFLUENZA VIRUS , CANINE PARVO VIRUS. Available from: ...
Adenovirus-2 (Hepatitis) Vaccination Information. Canine Hepatitis occurs when a dog ingests or breathes in bodily secretions ... Non-Core Dog Vaccine Information. Non-core vaccines are important to some dogs, but not to every dog. Non-core vaccinations for ... Your dog may need additional dog vaccines for localized diseases. Core vs Non-Core Vaccinations. Classifications for canine ... Dogs in boarding kennels, shelters and dog shows are most susceptible to this deadly disease. Unlike many dog diseases, ...
Find out what vaccinations your dog needs and when. ... Diseases dogs can catch. Adenovirus. Adenovirus is a viral ... Vaccinations can protect dogs against catching serious, sometimes fatal diseases. ... Adenovirus type 1 (also known as canine viral hepatitis). Type 1 enters a dogs system through their mouth, throat and tonsils ... Is there a vaccine for adenovirus?. Yes. Adenovirus can be prevented if you get your dog vaccinated. They need the initial ...
... adenovirus explanation free. What is adenovirus? Meaning of adenovirus medical term. What does adenovirus mean? ... Looking for online definition of adenovirus in the Medical Dictionary? ... Related to adenovirus: Canine adenovirus. adenovirus. [ad´ĕ-no-vi″rus] any of a large group of viruses causing disease of the ... mammalian adenoviruses Mastadenovirus. adenovirus. (ăd′n-ō-vī′rəs). n.. Any of a group of DNA-containing viruses that cause ...
  • Two types of Canine Adenovirus (CAVs), Canine Adenovirus type 1 (CAV-1), the virus which causes infectious canine hepatitis, and Canine Adenovirus type 2 (CAV-2), which causes canine infectious laryngotracheitis, have been found in dogs. (hindawi.com)
  • CAV-1 replicates in vascular endothelial cells and causes a generalized infection characterized by hepatitis [ 7 ], whereas CAV-2 has an affinity for respiratory tract epithelium and is mainly associated with outbreaks of respiratory disease in kenneled dogs [ 8 ]. (hindawi.com)
  • The ELISA was found to be a highly efficient and rapid test to determine the immune status of dogs to infectious canine hepatitis virus and canine adenovirus type 2 [ 15 ]. (hindawi.com)
  • CAV-1 causes infectious canine hepatitis -- a dangerous and potentially fatal infection. (vetstreet.com)
  • Adenovirus 1 in dogs is a virus that causes respiratory infections , targets multiple organs in the body, and causes infectious canine hepatitis (ICH) - a disease that severely affects the liver and can be fatal in as many as 30 percent of the dogs who suffer from it. (dogtime.com)
  • Infectious canine hepatitis can be mild with symptoms that are barely noticeable, or it can be severe and deadly. (dogtime.com)
  • Some dogs can be carriers of the disease without ever showing symptoms of infectious canine hepatitis at all. (dogtime.com)
  • Canine adenovirus (CAV) type 1 and 2, respectively, cause infectious canine hepatitis and infectious canine laryngotracheitis in members of the families Canidae and Ursidae worldwide. (scielo.org.za)
  • 1. Appel M J 1987 Canine adenovirus type 1 (infectious canine hepatitis virus). (scielo.org.za)
  • 6. Cabasso V J 1981 Infectious canine hepatitis. (scielo.org.za)
  • 7. Carmichael L E 1964 The pathogenesis of ocular lesions of infectious canine hepatitis. (scielo.org.za)
  • 10. Caudell D, Confer A W, Fulton R W, Berry A, Saliki J T, Fent G M, Ritchey J W 2005 Diagnosis of infectious canine hepatitis virus (CAV-1) infection in puppies with encephalopathy. (scielo.org.za)
  • 15. Green C 1990 Infectious canine hepatitis. (scielo.org.za)
  • Vaccines against infectious canine hepatitis have been developed as an alternative to canine adenovirus type 1 vaccines. (vetstream.com)
  • This article describes a case of glomerulonephritis and immunocomplex (IgM, IgG and C3c) deposition in the mesangium and basement membranes of a 2-year-old dog with canine viral hepatitis and dirofilariasis. (surrey.ac.uk)
  • Canine adenovirus type 1 (Canine mastadenovirus A) is the causative agent of infectious canine hepatitis (ICH), a worldwide, contagious disease of dogs. (thenativeantigencompany.com)
  • Canine adenovirus type 2 is related to canine adenovirus type 1 and used in vaccines to provide protection against canine infectious hepatitis. (thenativeantigencompany.com)
  • CAdV-1 is the causative agent of infectious canine hepatitis (so-called Rubarth's disease), a life-threatening disease of puppies. (thenativeantigencompany.com)
  • This disease affects unvaccinated juvenile dogs and is distinct from disease caused by Canine Adenovirus type 1 (Infectious Canine Hepatitis). (wordpress.com)
  • Canine Hepatitis occurs when a dog ingests or breathes in bodily secretions from an infected animal. (vetinfo.com)
  • Dog vaccines' schedules include vaccinations against Canine Hepatitis. (vetinfo.com)
  • Infectious canine hepatitis (ICH) is an acute liver infection in dogs caused by Canine mastadenovirus A , formerly called Canine adenovirus 1 (CAV-1). (wikipedia.org)
  • Diagnosis is made by recognizing the combination of symptoms and abnormal blood tests that occur in infectious canine hepatitis. (wikipedia.org)
  • There are various different types of hepatitis, which is a condition that affects the liver-not all of them are contagious, but there is one variant that is, known as infectious canine hepatitis. (pets4homes.co.uk)
  • Common dog vaccinations prevent some of the most fatal canine diseases such as Canine Parvovirus, Canine Distemper, Canine Hepatitis and Canine Parainfluenza. (kidsfreeware.com)
  • Even sharing similar toys, cages, food/drink bowls, etc. can be an easy avenue for contracting canine hepatitis. (kidsfreeware.com)
  • These include the usual vaccines for parvovirus, canine distemper, and hepatitis. (kidsfreeware.com)
  • Canine adenovirus type 1 (CAV-1) infection results in hepatitis in dogs . (bvsalud.org)
  • Our biological characterization of CAV1V will facilitate quality control of the canine hepatitis vaccine. (bvsalud.org)
  • Because infectious canine hepatitis is another name for canine adenovirus type 1, an H is sometimes used instead of A. In DA2PPC, the C indicates canine coronavirus. (wikipedia.org)
  • Distemper, adenovirus type 1 (thus hepatitis), parainfluenza, and parvovirus are covered by all 4, but only DAPPC covers coronavirus. (wikipedia.org)
  • Type 1 adenovirus, also called canine hepatitis, is a DNA viral upper respiratory infection contracted through contact of a mucous membrane. (wikipedia.org)
  • There are two strains of Adenovirus: Hepatitis (type 1), which is a disease of the liver, and Respiratory (type 2), which can contribute to Kennel Cough. (revivalanimal.com)
  • Vaccinations can prevent a number of canine diseases such as canine distemper, kennel cough, encephalitis, and hepatitis, among others. (petside.com)
  • Effective against Canine Parvo, Hepatitis, HIV-1 (AIDS virus), RSV Canine Distemper, Feline Leukemia, Rabies, Avian IBV, TGE and against Antibiotic-resistant strains of pathogens such as Salmonella and Staphylococcus. (jefferspet.com)
  • For subcutaneous vaccination of healthy dogs 6 weeks of age or older as an aid in the prevention of disease caused by canine distemper, infectious canine hepatitis, canine adenovirus type 2 and canine parvovirus (CPV). (drugs.com)
  • This product has been shown to be effective for the vaccination of healthy dogs 6 weeks of age or older against canine distemper, infectious canine hepatitis, canine adenovirus type 2, canine coronavirus, canine parainfluenza, canine parvovirus (CPV), Leptospira canicola, Leptospira icterohaemorrhagiae, Leptospira grippotyphosa and Leptospira pomona . (drugs.com)
  • Canine adenovirus one triggers hepatitis in puppies. (over-blog.com)
  • Along with Bordetella and parainfluenza, canine adenovirus type 2 (CAV-2) is one of the reasons dogs get kennel cough. (vetstreet.com)
  • Dogs with kennel cough should wear a harness rather than a neck collar when taken for walks during recovery. (vetstreet.com)
  • Keeping dogs out of facilities where animals have been known to be infected with kennel cough. (vetstreet.com)
  • 12. Ditchfield J, MacPherson L W, Zbitnew A 1962 Association of a canine adenovirus (Toronto A26/61) with an outbreak of laryngotracheitis (kennel cough). (scielo.org.za)
  • Canine influenza virus (CIV) or dog flu, is a highly contagious viral infection affecting dogs and is one of the viral causes of kennel cough. (homehealth-uk.com)
  • While most dogs will show typical symptoms of kennel cough, a small percentage of dogs will develop a more severe illness. (homehealth-uk.com)
  • CAV-2 is one of the major causes of infectious tracheobronchitis in dogs, also known as kennel cough. (zoologix.com)
  • Normally, symptoms of kennel cough will develop within a week after a dog has been exposed to CAV-2. (zoologix.com)
  • It is also one of the causes of infectious tracheobronchitis, also known as canine cough (kennel cough). (thenativeantigencompany.com)
  • it is one of the causes of infectious canine tracheobronchitis (kennel cough) and is often found in dog breeder stocks. (thenativeantigencompany.com)
  • Kennel cough is perhaps the most common of all canine health conditions that can be spread from dog to dog, and the risks increase greatly in environments where a lot of dogs congregate or live in close quarters, such as doggy day care facilities and boarding kennels. (pets4homes.co.uk)
  • Fortunately, kennel cough can be vaccinated against, and all responsible pet care facilities require dogs that they take in to be vaccinated against the condition before they can enter. (pets4homes.co.uk)
  • Kennel cough is also a risk for dogs in shelters and rehoming centres, as of course some of the dogs brought in will not be in good condition, and their vaccination status will not be known. (pets4homes.co.uk)
  • The kennel cough vaccine takes the form of a nasal spray, which means that it is important for dog owners to ask for the vaccine specifically, as many people wrongly assume that it is contained within the standard injected canine vaccine combination. (pets4homes.co.uk)
  • Canine influenza often presents with many of the same symptoms as kennel cough, and as such, the two are often confused. (pets4homes.co.uk)
  • However, the canine influenza virus is a different one to the form responsible for Kennel cough-although fortunately, this too is another condition that is commonly vaccinated against, this time within the usual combination injected vaccine. (pets4homes.co.uk)
  • DA2PPC does not include vaccination against Bordetella, but the combination of Bordetella with DA2PPC significantly reduces kennel cough infection through prevention of adenovirus, distemper, and parainfluenza. (wikipedia.org)
  • Adenovirus type 2 is responsible for the infectious, viral disease kennel cough. (wikipedia.org)
  • The parainfluenza virus is one of the many canine viral strains that can cause kennel cough. (wikipedia.org)
  • We frequently see unvaccinated puppies with parvovirus, which can be very rapidly fatal, and Kennel Cough is another extremely common illness that we see in dogs of all ages. (petdoctors.co.uk)
  • This respiratory disease is one of the culprits of canine Bronchitis, or Kennel Cough, which causes a dry hacking cough that can last for weeks. (revivalanimal.com)
  • Just as humans don't need a measles shot every year, neither do dogs or cats need annual injections for illnesses such as parvo, distemper or kennel cough. (freerepublic.com)
  • Bordatella bronchiseptica (Kennel Cough): Contagious bacteria that causes respiratory disease among dogs and less commonly cats. (embracepetinsurance.com)
  • The Puppy Dog Place suggests that puppies get other essential shots that prevent against critical diseases, such as Lyme Disease, Kennel Cough and Giardia. (over-blog.com)
  • Adenovirus vectors have significant potential for long- or short-term gene transfer. (mdpi.com)
  • This review updates canine adenovirus serotype 2 (CAV-2, also known as CAdV-2) biology and gives an overview of the generation of early region 1 (E1)-deleted to helper-dependent (HD) CAV-2 vectors. (mdpi.com)
  • Impact of adenovirus life cycle progression on the generation of canine helper-dependent vectors. (biomedsearch.com)
  • Helper-dependent adenovirus vectors (HDVs) are safe and efficient tools for gene transfer with high cloning capacity. (biomedsearch.com)
  • Canine adenovirus (Ad) type 2 vectors, holding attractive features to overcome immunogenic concerns and treat neurobiological disorders, were the focus of this work. (biomedsearch.com)
  • Recombinant forms of adenovirus are used as gene delivery vectors. (thefreedictionary.com)
  • The importance of Cre recombinase to minimize helper vector (HV) contamination during helper-dependent adenovirus vectors (HDVs) production is well documented. (cnrs.fr)
  • In this work, Cre-expressing cell stability, co-infection and their relation to adenovirus amplification/HV contamination were evaluated to develop a production protocol for HD canine adenovirus type 2 (CAV-2) vectors. (cnrs.fr)
  • Here, we show how Cre and MOI ratio impact adenovirus vectors yields and infectivity, providing key-information to design an improved manufacturing of HDV. (cnrs.fr)
  • Replication-deficient adenoviruses are among the most frequently used vectors for human gene therapy. (pnas.org)
  • If CAR is similarly regulated, manipulation of the Raf-MEK-ERK pathway could be central to an anticancer strategy using adenovirus vectors. (aacrjournals.org)
  • These data demonstrate that helper-dependent canine adenovirus vectors are capable of neural transduction and mediate long-term transgene expression, but increased SGSH expression throughout the brain is likely to be required in order to effectively treat all aspects of the MPS-IIIA phenotype. (edu.au)
  • Methods: Adult dogs received an intravenous injection of low-dose adenoviral vectors encoding human HGF and VEGF (HGF/VEGF), β-galactosidase (lacZ) or phosphate-buffered saline (PBS). (elsevier.com)
  • The potential lack of cellular and humoral memory is one reason we developed vectors from canine adenovirus serotype 2 (CAV-2). (cnrs.fr)
  • Adenovirus (Ad) serotype 5 based vectors have been developed as therapeutics for cancer in the recent decade and are the most frequently used viral gene vectors in clinical trials [ 1 ]. (pubmedcentralcanada.ca)
  • Clinical response to adenoviruses ranges from none to severe (e.g., with serotype 14). (thefreedictionary.com)
  • serotype 14: can cause potentially fatal adenovirus infections. (wikipedia.org)
  • Keeping puppies away from other dogs until the puppy vaccination series is complete. (vetstreet.com)
  • Dogs who aren't vaccinated, such as puppies who are too young to get the vaccination, have the highest risk of being infected. (dogtime.com)
  • Vaccination is quite successful in reducing the risk of the disease, and it's one of the core vaccinations recommended for all dogs. (dogtime.com)
  • Its effectiveness may decrease with time, and the American Animal Hospital Association further recommends that dogs receive the vaccination again every three years. (dogtime.com)
  • You should discuss a vaccination schedule with your vet to find out what's appropriate for your dog. (dogtime.com)
  • 13. Emery J B, House J A, Brown W R 1978 Cross-protective immunity to canine adeno-virus type-2 by canine adenovirus type-1 vaccination. (scielo.org.za)
  • The molecular basis of this difference remains uncertain, but this property is exploited for vaccination of dogs: specifically, although the use of live-attenuated canine adenovirus 1 vaccines sometimes results in blue eye because of the ability of the vaccine virus to replicate systemically, canine adenovirus 2 vaccines do not replicate systemically. (thenativeantigencompany.com)
  • Most infections with canine adenovirus 1 are asymptomatic, a situation probably enhanced by the introduction of vaccination. (thenativeantigencompany.com)
  • In any population of dogs a very small proportion may fail to adequately respond to vaccination due to concurrent illness, stress, immunosuppression, genetic factors or the presence of maternal antibodies. (petceutics.com.au)
  • Answer: Jan- At the present time there is no universally accepted vaccination protocol for dogs or cats. (vetinfo.com)
  • There is a documented rise in the cases of IMHA for the month following vaccination in dogs but it is a slight rise -- just barely enough to be statistically significant. (vetinfo.com)
  • Your pet's vaccination schedule depends on the breed, size of your dog and the area where you live. (vetinfo.com)
  • The American Veterinary Medical Association feels Distemper vaccinations are the most important vaccination for puppies and dogs. (vetinfo.com)
  • The mass vaccination of dogs is a proven tool for rabies prevention. (springer.com)
  • Besides parenteral delivery of inactivated vaccines, over the past several decades, several self-replicating biologics, including modified-live, attenuated and recombinant viruses, have been evaluated for the oral vaccination of dogs against rabies. (springer.com)
  • Due to the high affinity between dogs and humans, such biologics intended for oral vaccination of dogs (OVD) need to be efficacious as well as safe. (springer.com)
  • Parenteral mass dog vaccination programs associated with strict prophylactic measures have been effective in eliminating rabies in dogs in all developed countries, but prevention, control and eventually elimination of canine rabies has not been achieved in most developing countries. (springer.com)
  • This approach has been proposed as a complementary policy to parenteral vaccination of dogs to increase overall vaccination coverage, especially in areas having large populations of non-accessible animals. (springer.com)
  • Since 1988, the World Health Organisation (WHO) has supported numerous expert consultations regarding research coordination on oral vaccination of dogs (OVD) with the objective to promote the development and use of safe and effective rabies vaccines and baits. (springer.com)
  • Every country of the world have their own risks and conditions that are prevalent across their dog populations, which means that vaccinations vary in different countries-for instance, the UK is one of the few countries in the world where rabies is considered to have been eradicated, and so we do not give dogs the rabies vaccination as standard in the UK. (pets4homes.co.uk)
  • Dogs over 18 weeks of age that have not been previously vaccinated should receive the initial vaccination followed with a booster 2-4 weeks later. (medi-vet.com)
  • Proper vaccination is the best and only way to keep you and your dog safe. (asgoodasgold.org)
  • A vaccination of an adult dog is usually effective foe 3 to 5 years. (freedoglistings.com)
  • The vaccination is usually effective for a period of six to ten months and is typically administered with a nasal spray Most boarding kennels now insist on dogs been vaccinated before they enter the kennel, but it should be done at least 5 days before the dog is boarded as it will not be effective until then. (freedoglistings.com)
  • Vaccination reduces the likelihood of your dog contracting this infection and reduces the severity of the illness if your dog does become infected. (petdoctors.co.uk)
  • It is never too late to start a vaccination programme even for an older dog and your vet will be able to advise you on this. (petdoctors.co.uk)
  • In addition, most kennels will not take dogs for boarding unless they have an up to date vaccination record. (petdoctors.co.uk)
  • Vaccination safeguards the growth and development of the young dog. (petside.com)
  • He continued his experiment by measuring antibody levels in the dogs' blood nine and 15 years after vaccination. (freerepublic.com)
  • Until your puppy's vaccination course is complete and active (follow your vet's advice, but this is normally at between 11 to 13 weeks), they should not go to outside public areas, or any garden where an unvaccinated dog may have been. (bluecross.org.uk)
  • Your vet should provide you with a vaccination record card so that you know when your dog is due to have his or her boosters. (bluecross.org.uk)
  • Every vaccination can protect your dog against anything up to seven illnesses. (bluecross.org.uk)
  • By now, many savvy animal lovers are aware of the dangers of over-vaccination, and are opting against annual boosters for their dogs and cats. (animalwellnessmagazine.com)
  • In cats and dogs, aggressive tumors (fibrosarcomas) can occasionally arise at the site of vaccination. (animalwellnessmagazine.com)
  • 5 in 1 dog shot vaccination provides protection for any dog, including puppies and small breeds. (jefferspet.com)
  • Do you know anyone whose healthy dog has suffered an inexplicable illness shortly after a routine vaccination? (agilitynet.co.uk)
  • Our dogs do not become ill from the vaccination itself but, after attending a lecture in 2000 given by Dr. John Angles (1), I do hold the view that certain breeds and certain dogs are more susceptible to immune-medicated diseases than others. (agilitynet.co.uk)
  • However, Dr Angles has the view that, at present, the benefit of vaccination outweighs the problems but for those dogs who are susceptible to 'the problems,' there is no way of identifying particular individuals, and vaccinating these dogs is a bit like playing Russian Roulette. (agilitynet.co.uk)
  • He believes that, if a dog is susceptible, one of the booster jabs sets up a hypersensitivity and the following vaccination sets up the auto-immune system to react in some unpredictable way! (agilitynet.co.uk)
  • I also strongly believe in the benefits of vaccination, but I refuse to play Russian Routlette with the health of my dogs. (agilitynet.co.uk)
  • This means that I can continue to blood test my dogs and remove the need to play Russian roulette with their 'vaccination' health. (agilitynet.co.uk)
  • 3. Binn L N, Eddy G A, Lazar E C, Helms J, Murnane T 1967 Viruses recovered from laboratory dogs with respiratory disease. (scielo.org.za)
  • Respiratory disease in affected dogs is characterized principally by bronchitis and bronchiolitis. (thenativeantigencompany.com)
  • An essential difference between canine adenoviruses 1 and 2 is that, whereas canine adenovirus 1 causes systemic disease, canine adenovirus 2 infection results only in restricted respiratory disease. (thenativeantigencompany.com)
  • I'm under the impression that adult dogs do not need yearly vaccinations and that rabies vaccines need be given only every three years. (vetinfo.com)
  • State laws require dogs to have current vaccines for specific deadly diseases, such as rabies. (vetinfo.com)
  • Within a One Health context, OVD should be considered as part of a holistic plan for the global elimination of canine rabies. (springer.com)
  • More than 99% of all rabies human cases are transmitted by dog bites. (springer.com)
  • However, any dog that needs a pet passport because they travel to other countries will have to be vaccinated against rabies first, both to protect them against the condition and in order for them to be allowed back into the UK! (pets4homes.co.uk)
  • If your golden retriever is not current on its rabies vaccine and bites someone or sometimes even scratches a child, the law may require that your dog be quarantined or even euthanized to keep other pets and people safe. (asgoodasgold.org)
  • Rabies is spread when a dog is scratched or bitten by an infected animal. (freedoglistings.com)
  • Hence, you cannot expect that a rabies vaccine will protect your dog from another disease. (petside.com)
  • Both modified-live virus (MLV) and killed inactivated vaccines, such as those for canine distemper and rabies, respectively, have been associated with post-vaccinal encephalitis (PVE). (animalwellnessmagazine.com)
  • Additionally, vaccinating dogs with rabies vaccine, either alone or with other vaccines, can induce production of antithyroglobulin autoantibodies, which can contribute to the subsequent development of hypothyroidism. (animalwellnessmagazine.com)
  • Puppies may get infected with diseases such as canine distemper, rabies, canine adenovirus and parvorvirus without the administration of proper vaccines. (over-blog.com)
  • Vetinfo.com indicates that rabies and canine adenovirus are other essential puppy vaccines. (over-blog.com)
  • Scientists still have not found a cure for rabies, which affects dogs' brains. (over-blog.com)
  • Canine respiratory coronavirus. (routledge.com)
  • Like the others, coronavirus is transmitted through contaminated fecal material, food or water bowls, or contact with a previously infected dog. (wikipedia.org)
  • Aseptically rehydrate Duramune Max 5 with Canine Coronavirus Vaccine-Leptospira Bacterial extract supplied. (drugs.com)
  • Other agents implicated in this disease: canine parainfluenzavirus 2 Canine parainfluenza virus 2 , canine distemper virus Canine distemper virus and Bordetella bronchiseptica Bordetella bronchiseptica . (vetstream.com)
  • The CAV-2 vaccine also protects against infection with canine adenovirus type 1 (CAV-1). (vetstreet.com)
  • What is Canine Adenovirus Type-1? (homehealth-uk.com)
  • What are the symptoms of Canine Adenovirus Type-1? (homehealth-uk.com)
  • and canine adenovirus type 2 (CAV-2) which causes respiratory and enteric diseases. (zoologix.com)
  • Immunisation of healthy dogs, 6 weeks of age or older to protect against disease caused by canine distemper virus, canine adenovirus type 1, canine adenovirus type 2 and canine parvovirus. (petceutics.com.au)
  • The features of the pneumonia are diagnostic for Canine Adenovirus type 2. (wordpress.com)
  • However, tests suggest that the culprit is adenovirus type 3, a different strain than the one in Wanaque. (fox40.com)
  • We nebulized nedocromil sodium into beagle dogs (n = 10, mean ± SEM ages: 149 ± 13 days) before and after inoculation with canine adenovirus type 2 (CAV2). (elsevier.com)
  • Most combination vaccines for dogs contain a modified canine adenovirus type-2. (wikipedia.org)
  • Does your dog react fearfully or negatively to any type of person, animal, or object? (jotform.com)
  • A vial of desiccated canine distemper (MLV), canine adenovirus type 2 (KV), canine parainfluenza (MLV), with a vial of liquid canine parvovirus (MLV) as the diluent. (medi-vet.com)
  • DA2PP is a multivalent vaccine for dogs that protects against the viruses indicated by the alphanumeric characters forming the acronym: D for canine distemper, A2 for canine adenovirus type 2, which offers cross-protection to canine adenovirus type 1 (the more pathogenic of the two strains) (see Canine adenovirus), the first P for canine parvovirus, and the second P for parainfluenza. (wikipedia.org)
  • Adenovirus is prevented by the DA2PPC vaccine representing the adenovirus type 2. (wikipedia.org)
  • DA2PPC also protects against the more virulent strain, adenovirus Type 1 (see canine adenovirus). (wikipedia.org)
  • Adenovirus type 2 is used to make vaccines, and it protects against both strains. (revivalanimal.com)
  • Adenovirus-induced thrombocytopenia is a potentially serious complication of gene therapy protocols using this type of vector. (bloodjournal.org)
  • To investigate the effect of adenovirus-mediated overexpression of caveolin-3 on hypertrophic responses in cardiomyocytes, we constructed an adenovirus that encoded human wild-type caveolin-3 (Ad.Cav-3), mutant caveolin-3 (Ad.Cav-3Δ), or bacterial β-galactosidase (Ad.LacZ). (ahajournals.org)
  • We investigated the effect of adenovirus-mediated overexpression of wild-type and dominant-negative caveolin-3 on hypertrophic responses to G q -dependent agonists in cardiomyocytes. (ahajournals.org)
  • The aim of this study was to conduct a serological investigation of canine adenovirus infection. (scielo.org.za)
  • This vaccine prevents viral shedding caused by canine parvovirus infection. (petceutics.com.au)
  • Contains the essential viruses for core protection against the most lethal and prevalent respiratory viral diseases of dogs. (neotechvaccines.com)
  • Rather than needing to treat or cure viral and bacterial diseases , it's far better to prevent your dog from catching them in the first place. (directline.com)
  • Parvovirus is one of the most serious and nasty of all of the canine viral health conditions, and is also one for which there is no cure. (pets4homes.co.uk)
  • Parvovirus can be spread by the faces of affected dogs, as the viral load sheds in the stools. (pets4homes.co.uk)
  • Unlike the other contagious conditions that we have looked at so far, leptospirosis is a bacterial condition rather than a viral one, and is one that can lead to organ failure and death in infected dogs. (pets4homes.co.uk)
  • Ownerless dogs showed over a three-fold higher predisposition to viral coinfections than owned dogs. (hindawi.com)
  • Canine adenovirus -2 is a viral infection that causes inflammation of the liver. (asgoodasgold.org)
  • 250-bp) products from the matrix hemaglut- submitted to a canine infectious diseases laboratory were tinin and neuraminidase genes were used (details available negative for known canine viral pathogens (e.g., canine from the authors on request). (cdc.gov)
  • This virus is the more serious of the canine adenoviruses because adenovirus 2 usually only causes minor respiratory problems. (dogtime.com)
  • Even after a dog no longer shows symptoms of ICH, their urine can still spread the virus for six to nine months. (dogtime.com)
  • The symptoms of adenovirus 1 in dogs depend on a lot of factors, including the condition of the immune system, the amount of damage the virus does to the cells, and the stage of the disease. (dogtime.com)
  • Because the virus is contagious from dog to dog, it appears more often where groups of dogs are usually together, such as dog parks, kennels, or shelters. (dogtime.com)
  • 4. Böhm M, Thompson H, Weir A, Hasted A M, Maxwell N S, Herrtage M E 2004 Serum antibody titres to canine parvovirus, adeno-virus and distemper virus in dogs in the UK which had not been vaccinated for at least 3 years. (scielo.org.za)
  • Canine adeno-virus-induced ocular lesions in the Afghan hound. (scielo.org.za)
  • What is Canine Distemper virus ? (homehealth-uk.com)
  • Canine distemper is a virus that affects a dog's respiratory, gastrointestinal and central nervous systems, as well as the conjunctival membranes of the eye. (homehealth-uk.com)
  • What are the symptoms of Canine Distemper virus ? (homehealth-uk.com)
  • The virus is passed from dog to dog through direct contact with fresh urine, blood or saliva. (homehealth-uk.com)
  • Whilst there is currently no available medication that can destroy the virus that causes canine distemper, the virus spreads rapidly and must be aggressively treated as soon as it is discovered. (homehealth-uk.com)
  • The virus is spread via faeces and contaminated fluids from infected dogs, and may be present in a recovered dog for at least six months. (homehealth-uk.com)
  • What is Canine Influenza virus ? (homehealth-uk.com)
  • Because CIV is a relatively new virus , most dogs have not been exposed to it before. (homehealth-uk.com)
  • What are the symptoms of Canine Influenza virus ? (homehealth-uk.com)
  • The virus does not survive for a long time in the environment, so dogs usually get CIV when they are in close proximity to other infectious dogs. (homehealth-uk.com)
  • Recovered dogs shed virus in their urine for at least 6 months. (thenativeantigencompany.com)
  • This entry was posted in Necropsy Cases and tagged Bacteria , Canine , Respiratory , Virus . (wordpress.com)
  • Most commonly, a dog sneezes and passes the virus to other dogs in the area. (vetinfo.com)
  • The virus attacks the liver and affects dogs differently. (vetinfo.com)
  • Adenovirus capsid proteins are synthesized in the cytoplasm and transported to the nucleus for assembly into the virus particles. (novusbio.com)
  • Fiber plays a crucial role in adenovirus infection by attaching the virus to a specific receptor on the cell surface. (novusbio.com)
  • [1] The virus is spread in the feces, urine, blood, saliva, and nasal discharge of infected dogs. (wikipedia.org)
  • CAR 3 is a 46-kDa transmembrane protein that enables virus attachment via interaction with the adenovirus fiber-knob protein. (aacrjournals.org)
  • Additionally, the virus is a very hardy one that can survive outside of the body for anything up to 48 hours, which means that dogs do not have to come into direct contact with each other in order to transmit the virus. (pets4homes.co.uk)
  • Parvoviruses: canine parvovirus and feline panleukopenia virus. (routledge.com)
  • Canine Distemper virus is considered a core vaccine. (asgoodasgold.org)
  • Canine distemper is a contagious and serious disease caused by a virus that attacks the respiratory, gastrointestinal and nervous systems of dogs and puppies. (asgoodasgold.org)
  • Puppies and dogs most often become infected through airborne exposure (coughing and sneezing) to the virus from an infected dog or wild animal. (asgoodasgold.org)
  • Infected dogs can shed the virus for months and mother dogs can pass the virus through the placenta to their puppies. (asgoodasgold.org)
  • Canine parvovirus is a highly contagious virus that can affect all dogs, but unvaccinated dogs and puppies younger than four months of age are the most at risk. (asgoodasgold.org)
  • The virus affects dogs' gastrointestinal tracts and is spread by direct dog-to-dog contact and contact with contaminated feces, environments, or people. (asgoodasgold.org)
  • The virus can also contaminate kennel surfaces, food and water bowls, collars and leashes and the hands and clothing of people who handle infected dogs. (asgoodasgold.org)
  • The virus is readily transmitted for place to place on the hair or feet of dogs or via contaminated cages, shoes or other objects. (asgoodasgold.org)
  • Young dogs are at highest risk of contracting this virus. (asgoodasgold.org)
  • There is no antiviral drug effective against the canine distemper virus. (wikipedia.org)
  • Again you should ensure that your dog has been fully protected against the virus before boarding. (freedoglistings.com)
  • The Measles virus vaccine induces immunity to canine Distemper virus. (revivalanimal.com)
  • A combined canine Distemper and Measles virus vaccine increases the protection of puppies against Distemper during the period when they commonly carry maternal antibodies. (revivalanimal.com)
  • For instance, dogs with intestinal parvovirus can pass the virus in the feces. (petside.com)
  • The virus causes severe vomiting and diarrhoea which leads to a dog or puppy becoming very weak and dehydrated. (bluecross.org.uk)
  • Highly contagious, often fatal, virus that is spread among dogs and some wildlife. (embracepetinsurance.com)
  • Highly contagious, often fatal, virus spread among dogs. (embracepetinsurance.com)
  • Adenovirus-induced endothelial cell activation was shown by VCAM-1 expression on virus-treated, cultured endothelial cells and by the release of ultra-large molecular weight multimers of VWF within 1 to 2 hours of virus administration with an accompanying elevation of endothelial microparticles. (bloodjournal.org)
  • Canine distemper is an extremely contagious disease provoked by a virus. (over-blog.com)
  • The primary means of infection are through canine faeces and the consumption of rodents that carry the virus. (over-blog.com)
  • Entry of adenoviruses into the host cell involves two sets of interactions between the virus and the host cell. (wikipedia.org)
  • With the help of cellular microtubules, the virus is transported to the nuclear pore complex, whereby the adenovirus particle disassembles. (wikipedia.org)
  • We also demonstrated that canine respiratory tissue possesses the relevant receptors A/equine/Newmarket/1/93 and A/equine/Newmarket/2/93 for infection with equine infl uenza virus. (cdc.gov)
  • Reverse transcription-PCR herpesvirus, adenovirus, parainfl uenza virus). (cdc.gov)
  • 80% of all puppies and 50% of adult dogs that contract Canine Distemper succumb to the disease. (vetinfo.com)
  • Puppies are given two injections as standard that protect them from three diseases: Adenovirus, Distemper and Parvovirus. (directline.com)
  • Parvovirus is most dangerous to young puppies and older dogs with a compromised immune system, and often proves fatal in puppies. (pets4homes.co.uk)
  • Fortunately, the condition is also included in the standard combination canine vaccines, and all puppies should have these before going outside or coming into contact with other dogs. (pets4homes.co.uk)
  • Once more, the condition is more dangerous to young puppies whose immune systems are not fully active, although it can potentially be fatal in otherwise healthy adult dogs too. (pets4homes.co.uk)
  • Canine adenovirus 1 (CAdV-1) can lead to death in puppies, or encephalitis in other carnivore species. (wikipedia.org)
  • Unvaccinated dogs and puppies are most susceptible to the disease. (wikipedia.org)
  • see canine parvovirus) Puppies under 4 months old and unvaccinated canines are the most susceptible to the disease. (wikipedia.org)
  • Mostly affects puppies although adult dogs can be infected. (petdoctors.co.uk)
  • Parvovirus is Mainly a disease of unvaccinated puppies and dogs. (nairaland.com)
  • Puppies, specifically under six months, are prone to suffer from canine distemper. (over-blog.com)
  • These dog shots are also vital for puppies' health. (over-blog.com)
  • Worms are a reality in most dogs and puppies at some point in their lives. (over-blog.com)
  • Canine Spectra 5 offers a 5 Way protection for any dog, including puppies and small breeds. (jefferspet.com)
  • Adenoviruses (members of the family Adenoviridae) are medium-sized (90-100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome. (wikipedia.org)
  • Vaccines to prevent adenovirus 1 infections in dogs are usually given alongside the canine distemper vaccine, as it's one of the core vaccines recommended for all dogs except in unusual circumstances where dogs cannot receive it. (dogtime.com)
  • How do you make sure your dog is safe from infections? (dogtime.com)
  • Both of these infections are acute diseases, especially in young dogs. (scielo.org.za)
  • Vets can offer intravenous fluids to prevent dehydration and antibiotics to ward off secondary infections while the infected dog builds up his immune response. (homehealth-uk.com)
  • Whereas canine adenovirus 1 is a common infection of foxes, wolves, and coyotes, evidence for canine adenovirus 2 infections in wildlife is lacking. (thenativeantigencompany.com)
  • Other types of adenovirus infections can cause flu-like symptoms, pinkeye and diarrhea. (fox40.com)
  • [4] CAV-2 is one of the causes of respiratory infections in dogs, but it is similar enough to CAV-1 that vaccine for one creates immunity for both. (wikipedia.org)
  • Several factors are thought to predispose young dogs to microbiological infections. (hindawi.com)
  • This may look like a benign health condition in dogs, but it can also lead to secondary infections which may require extensive hospitalization and more aggressive treatments using antibiotics. (petside.com)
  • Dogs that have active infections can also transmit the microorganism to others through their excrement, saliva, and other body fluids. (petside.com)
  • Multiple human adenovirus (HAd) infections during childhood generate a memory T-cell (T(M)) response, which is the primary defense against HAd-induced morbidity. (cnrs.fr)
  • Common bacterial causes of pneumonia in dogs do include E coli, particularly in newborn pups, as well as Klebsiella pneumoniae, Bordetella bronchiseptica, Pasteurella spp, and Streptococcus spp. (wordpress.com)
  • Their logic: a) It is obvious that some dogs react badly to vaccinations, either at the time they are given or several weeks later by experiencing immune mediated hemolytic anemia (IMHA). (vetinfo.com)
  • In 2006, the American Animal Hospital Association released new guidelines for canine vaccinations. (vetinfo.com)
  • Classifications for canine vaccinations include core or non-core. (vetinfo.com)
  • Non-core vaccinations for dogs protect against diseases localized to certain regions in the world. (vetinfo.com)
  • Keep your vaccinations for dogs up to date and prevent this fatal disease. (vetinfo.com)
  • Vaccinations can significantly reduce the risk of your dog catching diseases and passing them onto others. (directline.com)
  • What are dog vaccinations? (directline.com)
  • Vaccinations are an effective way of limiting the risk, helping to protect your dog from infection while stopping disease from spreading. (directline.com)
  • Despite this, the latest Paw Report from leading veterinary charity PDSA shows that 25% of owners hadn't given their puppy its first course of vaccinations, and that 23% of dogs don't get regular boosters. (directline.com)
  • Good breeders and rehoming charities should be able to tell you what vaccinations your dog has had. (directline.com)
  • Are dog vaccinations safe? (directline.com)
  • While the initial set of puppy vaccinations will set your dog up well, it'll need boosters to get the full benefits. (directline.com)
  • All Pit Crew dogs must be current on all core and state required vaccinations. (jotform.com)
  • Please select all current vaccinations for your dog. (jotform.com)
  • Core vaccinations are almost always necessary for the long-term wellbeing of the life of a dog. (wikipedia.org)
  • Non-core vaccinations are there for preventative measures that may protect against deadly diseases that the dog may encounter in their lifespan. (wikipedia.org)
  • Below is a list of typical vaccinations and inoculations that your dog may need or your vet may administer. (freedoglistings.com)
  • Why does my dog need vaccinations? (bluecross.org.uk)
  • Vaccinations protect your dog against killer diseases and they are likely to be a requirement if your dog goes into boarding kennels or travels abroad with you. (bluecross.org.uk)
  • But, if for any reason you are unsure if your dog has had its vaccinations, consult your vet for advice. (bluecross.org.uk)
  • How often will my adult dog need booster vaccinations? (bluecross.org.uk)
  • There seems to be a lot of confusion and some very common misconceptions about puppy shots and dog vaccinations in general. (jefferspet.com)
  • I know of many people, including myself, whose healthy dogs have suffered an inexplicable illness shortly following regular vaccinations. (agilitynet.co.uk)
  • Instead I have the necessary full puppy vaccinations and, at yearly intervals, have a blood test to indicate my dog s antibody status, costing about 40/dog. (agilitynet.co.uk)
  • Canine parainfluenza and leptospira vaccinations are short lived, should be repeated annually and not detected by the tests used by my vet but canine parvovirus, distemper and adenovirus are detectable. (agilitynet.co.uk)
  • Although one vaccine company is now recommending the canine parvovirus, distemper and adenovirus vaccinations together once every three years, with annual jabs for parainfluenza and leptospira. (agilitynet.co.uk)
  • I hope that this article will provide those worried about canine vaccinations with an alternative route to follow. (agilitynet.co.uk)
  • His research is focused on looking for gene or chromosome markers to determine which dogs are susceptible to immune related disease following routine vaccinations, within certain breeds. (agilitynet.co.uk)
  • The Native Antigen Company is pleased to offer antigens for both Canine Adenovirus 1 and Canine Adenovirus 2, which can be used for immunoassay development and other applications. (thenativeantigencompany.com)
  • The CAV-2 vaccine is typically given in a combination vaccine that also protects against other serious diseases, such as canine distemper and canine parvovirus infection . (vetstreet.com)
  • Try our canine breeding PCR panel - 3 canine sexually transmitted diseases tested from swabs or semen samples. (zoologix.com)
  • Both canine adenovirus (CAdV-1) and canine adenovirus 2 (CAdV-2) are spread similarly, but the resulting diseases are vastly different. (thenativeantigencompany.com)
  • Your dog may need additional dog vaccines for localized diseases. (vetinfo.com)
  • Some of these diseases spread through contact with infected animals, lessening the threat to dogs that rarely leave their home. (vetinfo.com)
  • Unlike many dog diseases, Parvovirus kills a dog within two or three days. (vetinfo.com)
  • Just like all members of the household, your dog needs to be protected from infectious diseases. (directline.com)
  • Many diseases can be painful, incurable or fatal to dogs. (directline.com)
  • Dogs are more likely to recover from diseases when they're older and stronger. (directline.com)
  • Adenoviruses cause acute respiratory, ocular, and enteric diseases, with significant health concerns for immunocompromised individuals. (pnas.org)
  • Human adenoviruses (HAdVs) are large (∼150 nm in diameter, 150-MDa) nonenveloped double-stranded DNA (dsDNA) viruses that cause respiratory, ocular, and enteric diseases ( 1 ). (pnas.org)
  • While canine distemper is less common than the previous two diseases, the infection can be passed along for months. (kidsfreeware.com)
  • Thankfully, some of the most common dog diseases are preventable. (kidsfreeware.com)
  • On the other hand, non-core vaccines are more appropriate for dogs whose lifestyle or environment put them at risk to other diseases. (kidsfreeware.com)
  • Infectious diseases are a common cause of death in young dogs. (hindawi.com)
  • It provides a pathway for clinicians through this complex field by highlighting the most clinically relevant aspects of a wide range of diseases, and granting them consideration for placement on dog and cat differential lists. (routledge.com)
  • This concise reference guide will be an invaluable tool for clinicians as they develop their understanding of, and ability to communicate about, infectious diseases of the dog and cat. (routledge.com)
  • Some of the diseases mentioned below are treatable but some can be fatal which is why it is wise to vaccinate against them to help protect your dog. (petdoctors.co.uk)
  • They prepare your dog in fighting certain diseases. (petside.com)
  • Like diseases among humans, treating diseases in dogs requires pet parents to shell out money from their savings. (petside.com)
  • https:///CanineEducation many common dog diseases can either be prevented or treated with available vaccines. (nairaland.com)
  • Dogs can contact many diseases wither transmitted by contact with other infected dogs, food, polluted environment or others. (nairaland.com)
  • In the Akita population, he has found there is a 9.3% prevalence of a dog falling foul to one of the serious immune-mediated diseases and this prevalence does not follow particular breed lines. (agilitynet.co.uk)
  • There are currently no images for Adenovirus Hexon Antibody (NB100-65051G). (novusbio.com)
  • Be the first to review our Adenovirus Hexon Antibody (3G0) [DyLight 488] and receive a gift card or discount. (novusbio.com)
  • There are no publications for Adenovirus Fiber Antibody (NB600-541-PBSONLY). (novusbio.com)
  • The presence of maternal antibody is known to interfere with the development of active immunity in dogs and additional boosters will be required in most young animals. (drugs.com)
  • The record of my dog s antibody levels are attached and it makes fascinating reading. (agilitynet.co.uk)
  • Live attenuated canine adenovirus 2 vaccines protect against CAV1 and CAV2. (vetstream.com)
  • This is an extremely severe strain of adenovirus that couldn't have occurred in a worse place," Elnahal said Friday. (fox40.com)
  • The various vaccine combinations were tested by blending monovalent recombinant adenovirus vaccines, each expressing hemagglutinin from a single strain. (springer.com)
  • The leading cause of death in dogs, Distemper is a contagious disease of the intestinal tract and respiratory system, and it eventually spreads to the brain. (revivalanimal.com)
  • Adenovirus 1 is contagious and can spread through an infected dog's saliva or feces. (dogtime.com)
  • It spreads through the saliva or feces of infected dogs, and it can still spread in the urine of dogs who recover from infection for six to nine months. (dogtime.com)
  • The disease commonly transmits to dogs through contact with infected feces, breathing contaminated airborne saliva from a sneeze or cough, contact with urine, or spending time where dogs congregate. (dogtime.com)
  • Both adenoviruses are spread from dog-to-dog interactions through infected respiratory secretions or contact with contaminated feces or urine. (thenativeantigencompany.com)
  • Ingestion of urine, feces, or saliva of infected dogs is the main route. (thenativeantigencompany.com)
  • In this work , the search of genomes of human and canine adenoviruses in feces from these wild carnivores was used to track the dissemination of domestic animals and human pathogens to the free-living populations in a wildlife reserve located in southern Brazil . (bvsalud.org)
  • An important determining factor for the successful entry of such adenoviruses into target cells is expression of the coxsackievirus and adenovirus receptor (CAR) at the cell surface. (aacrjournals.org)
  • Here, we demonstrate that in the adult brain, the coxsackievirus and adenovirus receptor (CAR) is located on neuron projections, at the presynapse in mature neurons, and on the soma of immature neurons in the hippocampus. (jneurosci.org)
  • We have also shown that adenovirus interferes with adhesion of platelets to a fibronectin-coated surface and flow cytometry revealed the presence of the Coxsackie adenovirus receptor on the platelet surface. (bloodjournal.org)
  • The two currently established receptors are: CD46 for the group B human adenovirus serotypes and the coxsackievirus/adenovirus receptor (CAR) for all other serotypes. (wikipedia.org)
  • It is the co-receptor interaction that stimulates entry of the adenovirus. (wikipedia.org)
  • In this study, blood samples taken from 111 dogs, which were admitted to the Internal Medicine Clinic of Selcuk University, Faculty of Veterinary Medicine, with clinical symptoms. (hindawi.com)
  • Treatment for adenovirus 1 infection in dogs is aimed at reducing the severity of symptoms because there is no cure for adenovirus 1. (dogtime.com)
  • There is no cure for adenovirus 1, but treatment can decrease the severity of the symptoms. (homehealth-uk.com)
  • Some dogs are able to survive the infection, while for others canine distemper can be fatal so early diagnosis and treatment is essential. (homehealth-uk.com)
  • Distemper is often fatal, and dogs that survive usually have permanent, irreparable nervous system damage. (asgoodasgold.org)
  • The movement to extend vaccine intervals is gaining ground because of growing evidence that vaccines themselves can trigger a fatal cancer in cats and a deadly blood disorder in dogs. (freerepublic.com)
  • Adenoviruses are linear, double-stranded DNA viruses which infect a wide variety of mammals and birds. (zoologix.com)
  • Panasonic Corporation has verified that nano-size charged water particles generated by applying a high voltage to water, which is referred to as nanoe™, has a suppression effect on pet (dog, cat) related allergens, bacteria, fungi, and viruses. (panasonic.com)
  • There is still no treatment for most viruses that affect dogs today. (petdoctors.co.uk)
  • The ProVet Logic Animal Facility Concentrated Disinfectant provides deep cleaning action that kills many of the most common dog and cat viruses including parvovirus. (revivalanimal.com)
  • Adenoviruses represent the largest known non-enveloped viruses. (wikipedia.org)
  • 9. Castleman W L 1985 Bronchiolitis obliterans and pneumonia induced in young dogs by an experimental adenovirus infection. (scielo.org.za)
  • Try our canine anemia PCR panel or our feline anemia PCR panel -- detect and differentiate multiple anemia pathogens from 1 blood sample. (zoologix.com)
  • An adult dog's behavior depends on its breed, training and situation, but, in general a dog responds to the way it is trained and treated, particularly when a puppy. (wikibooks.org)
  • Dogs developed a vaccine-related disease in which the dog's body rejects its own blood. (freerepublic.com)
  • My dog's immune status is then recorded on its individual caccination record card should a dog club or kennel wish to see it. (agilitynet.co.uk)
  • In total, 82 of 94 dogs (87.2 %) were found to be positive for CAV serum antibodies. (scielo.org.za)
  • If your dog gets exposed to an antigen that it already has antibodies to, then the infection will not proceed. (petside.com)
  • In severe cases, dogs may need blood transfusions. (dogtime.com)
  • It is more common and more severe among young dogs who have not yet been vaccinated. (homehealth-uk.com)
  • Together, the cement proteins exclusively stabilize the hexon shell, thus rendering penton vertices the weakest links of the adenovirus capsid. (pnas.org)
  • Recognizes the hexon group antigen present in most adenovirus serotypes. (novusbio.com)
  • 14. Erdogan Mözbeyaz C 2004 Investigation of blood protein polymorphism and estimation of genetic distances in some dog breeds in Turkey. (scielo.org.za)
  • EX-CELL MDCK is a serum-free, animal-protein free medium designed and optimized to support high-density culture of Madin Darby Canine Kidney (MDCK) cells. (sigmaaldrich.com)
  • EX-CELL MDCK is a serum-free, animal-protein free medium specially formulated to support large-scale, high-density MDCK culture and adenovirus production. (sigmaaldrich.com)
  • This permits untethering and release of the membrane-lytic segment, thereby providing the molecular basis for maturation cleavage of protein VI in adenovirus-mediated endosome disruption. (pnas.org)
  • We injected an adenoviral vector expressing a synthetic utrophin into tibialis anterior muscles of newborn dogs affected with CXMD and examined transgene expression by RNA and protein analysis at 10, 30 and 60 days postinjection in cyclosporin-treated and -untreated animals. (ox.ac.uk)
  • In the dog with pacing-induced heart failure, expression of caveolin-3 protein is increased. (ahajournals.org)
  • The capsid is destabilized and protein VI, which is one of the capsid constituents (see Adenovirus genome) is released from it. (wikipedia.org)
  • In this study, we have evaluated a gene therapy approach using a helper-dependent canine adenovirus vector that expresses human SGSH as a means of delivering sustained transgene expression to the brain. (edu.au)
  • Adenovirus 5 early region 1A (E1A) has been shown to exhibit high tumor suppressor activity, and gene therapy using E1A has been tested in clinical trials. (nature.com)
  • Dystrophic phenotype of canine X-linked muscular dystrophy is mitigated by adenovirus-mediated utrophin gene transfer. (ox.ac.uk)
  • We performed mini-utrophin gene transfer in Golden Retriever dogs with canine muscular dystrophy (CXMD). (ox.ac.uk)
  • Presented are ways to address the problem of replication competent adenovirus in adenoviral production for use with, for example, gene therapy. (freepatentsonline.com)
  • Parvo is contracted by dog-to-dog contact, contaminated fecal matter, water or food bowls, shared items, and even the clothing and floor of people who have handled dogs with parvovirus previously. (wikipedia.org)
  • I now know that parvo, parainfluenza and lepto can be obtained singly but adenovirus and distemper usually come as a joint combination. (agilitynet.co.uk)
  • This dog can also get parvovirus infection. (petside.com)
  • The smallest known adult dog was a Yorkshire Terrier, that stood only 6.3 centimetres (2.5 in) at the shoulder, 9.5 cm (3.7 in) in length along the head-and-body, and weighed only 113 grams (4.0 oz). (wikibooks.org)
  • Preclinical and clinical studies using human derived adenoviruses (HAd) have demonstrated the feasibility of flexible hybrid vector designs, robust expression and induction of protective immunity. (mdpi.com)
  • In this study we investigated the effect of signaling through the Raf-MEK-ERK pathway on CAR expression in cell line models of human cancers (pancreatic and colorectal) that are potential targets for adenovirus-based therapies. (aacrjournals.org)
  • wild dogs are dogs that have lost the benefit of daily human contact and care and reverted to a more wild status, similar to their ancestry, the wolf. (wikibooks.org)
  • industrial dogs are reserved for industrial and human consumption, form use of the hide and fur to meat or subjects for bio-chemical test. (wikibooks.org)
  • The effects of human attentional state on canine gazing behaviour: a comparison of free-ranging, shelter, and pet dogs. (bioportfolio.com)
  • This study examined how three groups of domestic dogs from different populations (free-ranging dogs, pet dogs, and shelter dogs) responded to a human during three attentional state conditions: when the human was making eye contact (attentive), when the human was turned away (inattentive), and when the human exited the testing area. (bioportfolio.com)
  • Free-ranging dogs responded to the human's change in attentional state by looking significantly less at the human in the inattentive condition compared to the attentive condition. (bioportfolio.com)
  • However, they gazed significantly more at the human in both the inattentive and attentive conditions compared to the free-ranging dogs and also spent more time in the proximity of the experimenter. (bioportfolio.com)
  • This study suggests that life experience plays an important role in how dogs respond to the attentional state of a human. (bioportfolio.com)
  • The incidence of human disease is related to canine infection. (bioportfolio.com)
  • Human Norovirus Infection in Dogs, Thailand. (bioportfolio.com)
  • The study aims to optimize and define a reproducible and non-invasive method for canine assisted lung cancer detection, using human breath samples from patients and controls for training a. (bioportfolio.com)
  • Results: Human HGF and VEGF expressions were detected only in the liver of HGF/VEGF dogs at day 2 after injection but declined at sacrifice (day 7). (elsevier.com)
  • A survey for human enteroviruses in dogs and man. (canarydatabase.org)
  • In 2010, the structure of the human adenovirus was solved at the atomic level, making it the largest high-resolution model ever. (wikipedia.org)
  • A review of 65 years of human adenovirus seroprevalence. (nih.gov)
  • Adenoviruses replicate and are assembled in the nucleus of the host cell. (vetstream.com)
  • Adenoviruses possess a linear dsDNA genome and are able to replicate in the nucleus of vertebrate cells using the host's replication machinery. (wikipedia.org)
  • Dogs with CAV-2 typically exhibit a dry, hacking cough and retching. (vetsecure.com)
  • Canine adenovirus two affects the respiratory system and cause cough. (over-blog.com)
  • Because CAV-2 is common and the CAV-2 vaccine cross-protects against CAV-1, the CAV-2 vaccine is considered a core vaccine by organized veterinary medicine, meaning that all dogs should receive this vaccine. (vetstreet.com)
  • Canine adenovirus -2 is considered a core vaccine. (asgoodasgold.org)
  • In conclusion, this study clearly demonstrates the high prevalence of CAV infection in dogs. (hindawi.com)
  • Acute thrombocytopenia has been consistently reported following intravenous administration of adenovirus. (bloodjournal.org)
  • Seventy-seven dogs were sampled from Isparta and Burdur dog shelters by random sampling, regardless of the clinical findings. (hindawi.com)
  • Dogs may develop bronchopneumonia, conjunctivitis, photophobia, and a transient corneal opacity, "blue eye", which may occur after clinical recovery as result of anterior uveitis and oedema [ 9 , 10 ]. (hindawi.com)
  • Infectious canine tracheobronchitis is usually diagnosed based on clinical signs and a history of possible exposure (such as a recent trip to a groomer or boarder). (vetstreet.com)
  • Infectious canine tracheobronchitis is usually diagnosed based on clinical signs and a history of possible exposure (such as a recent trip to a grooming salon or boarding facility). (vetsecure.com)
  • Canine adenovirus (CAV) can be grouped into two distinct but related serotypes, CAV-1 and CAV-2, based on serological tests [ 1 ] and molecular analyses [ 2 - 4 ]. (hindawi.com)
  • Baits should be preferentially attractive to dogs and not to non-target species. (springer.com)
  • And though the disease typically runs its course without longterm effects, it can lead to a more serious infection so you should speak with your vet if you think your dog has been infected. (vetstreet.com)
  • After CAV-2 has been transmitted to a dog, the incubation (development) period of the disease is approximately 3 to 10 days. (vetstreet.com)
  • Rather, the vaccine limits the severity of infection so that vaccinated dogs typically experience a milder form of the disease. (vetstreet.com)
  • Canine adenovirus 2 vaccines, however, provide complete homologous and cross-protection against disease induced by canine adenovirus 1. (thenativeantigencompany.com)
  • Dogs that do survive the disease end up with dental, vision and nervous system problems. (vetinfo.com)
  • Dogs in boarding kennels, shelters and dog shows are most susceptible to this deadly disease. (vetinfo.com)
  • Rabid dogs often attack people and spread the disease to humans. (vetinfo.com)
  • The disease can be confused with canine parvovirus because both will cause a low white blood cell count and bloody diarrhea in young, unvaccinated dogs. (wikipedia.org)
  • The DA2PPC vaccine protects against the debilitating and deadly disease canine distemper. (wikipedia.org)
  • The disease is passed from dog-to-dog by close spaces such as boarding venues, kennels, pounds, pet shops and contacted with infected material like bedding or through mucous membrane secretions like coughing or sneezing of the infected dog. (wikipedia.org)
  • You also don't want the amount to be too high that the dog gets the full-blown infection and disease. (petside.com)
  • Distemper is the leading cause of infectious disease death in dogs. (nairaland.com)
  • It's unusual for a dog to refuse more than one or two meals and this can indicate anything from depression to disease. (nairaland.com)