Adenovirus Vaccines: Vaccines used to prevent infection by any virus from the family ADENOVIRIDAE.Adenoviruses, Human: Species of the genus MASTADENOVIRUS, causing a wide range of diseases in humans. Infections are mostly asymptomatic, but can be associated with diseases of the respiratory, ocular, and gastrointestinal systems. Serotypes (named with Arabic numbers) have been grouped into species designated Human adenovirus A-F.Viral Vaccines: Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.Adenoviridae: A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.Adenovirus Infections, Human: Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses.Vaccines, Synthetic: Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.Genetic Vectors: DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.Vaccines: Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.Vaccines, Inactivated: Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.Adenovirus E1A Proteins: Proteins transcribed from the E1A genome region of ADENOVIRUSES which are involved in positive regulation of transcription of the early genes of host infection.Vaccines, DNA: Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.Vaccines, Combined: Two or more vaccines in a single dosage form.Adenoviridae Infections: Virus diseases caused by the ADENOVIRIDAE.Bacterial Vaccines: Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.AIDS Vaccines: Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.Adenovirus Early Proteins: Proteins encoded by adenoviruses that are synthesized prior to, and in the absence of, viral DNA replication. The proteins are involved in both positive and negative regulation of expression in viral and cellular genes, and also affect the stability of viral mRNA. Some are also involved in oncogenic transformation.Adenovirus E1B Proteins: Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression.Adenovirus E3 Proteins: Proteins transcribed from the E3 region of ADENOVIRUSES but not essential for viral replication. The E3 19K protein mediates adenovirus persistence by reducing the expression of class I major histocompatibility complex antigens on the surface of infected cells.Adenovirus E4 Proteins: Proteins transcribed from the E4 region of ADENOVIRUSES. The E4 19K protein transactivates transcription of the adenovirus E2F protein and complexes with it.Vaccines, Subunit: Vaccines consisting of one or more antigens that stimulate a strong immune response. They are purified from microorganisms or produced by recombinant DNA techniques, or they can be chemically synthesized peptides.Vaccines, Conjugate: Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.Vaccination: Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.Malaria Vaccines: Vaccines made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents.Adenovirus E1 Proteins: The very first viral gene products synthesized after cells are infected with adenovirus. The E1 region of the genome has been divided into two major transcriptional units, E1A and E1B, each expressing proteins of the same name (ADENOVIRUS E1A PROTEINS and ADENOVIRUS E1B PROTEINS).Papillomavirus Vaccines: Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.Meningococcal Vaccines: Vaccines or candidate vaccines used to prevent infection with NEISSERIA MENINGITIDIS.Hepatitis B Vaccines: Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced.Adenoviruses, Canine: Species of the genus MASTADENOVIRUS that causes fever, edema, vomiting, and diarrhea in dogs and encephalitis in foxes. Epizootics have also been caused in bears, wolves, coyotes, and skunks. The official species name is Canine adenovirus and it contains two serotypes.Measles Vaccine: A live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had measles or been immunized with live measles vaccine and have no serum antibodies against measles. Children are usually immunized with measles-mumps-rubella combination vaccine. (From Dorland, 28th ed)Pertussis Vaccine: A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Rabies Vaccines: Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.Haemophilus Vaccines: Vaccines or candidate vaccines containing antigenic polysaccharides from Haemophilus influenzae and designed to prevent infection. The vaccine can contain the polysaccharides alone or more frequently polysaccharides conjugated to carrier molecules. It is also seen as a combined vaccine with diphtheria-tetanus-pertussis vaccine.BCG Vaccine: An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.Poliovirus Vaccine, Inactivated: A suspension of formalin-inactivated poliovirus grown in monkey kidney cell tissue culture and used to prevent POLIOMYELITIS.Rotavirus Vaccines: Vaccines or candidate vaccines used to prevent infection with ROTAVIRUS.Cholera Vaccines: Vaccines or candidate vaccines used to prevent infection with VIBRIO CHOLERAE. The original cholera vaccine consisted of killed bacteria, but other kinds of vaccines now exist.Adenovirus E2 Proteins: Proteins transcribed from the E2 region of ADENOVIRUSES. Several of these are required for viral DNA replication.Typhoid-Paratyphoid Vaccines: Vaccines used to prevent TYPHOID FEVER and/or PARATYPHOID FEVER which are caused by various species of SALMONELLA. Attenuated, subunit, and inactivated forms of the vaccines exist.Smallpox Vaccine: A live VACCINIA VIRUS vaccine of calf lymph or chick embryo origin, used for immunization against smallpox. It is now recommended only for laboratory workers exposed to smallpox virus. Certain countries continue to vaccinate those in the military service. Complications that result from smallpox vaccination include vaccinia, secondary bacterial infections, and encephalomyelitis. (Dorland, 28th ed)Tuberculosis Vaccines: Vaccines or candidate vaccines used to prevent or treat TUBERCULOSIS.Mastadenovirus: A genus of ADENOVIRIDAE that infects MAMMALS including humans and causes a wide range of diseases. The type species is Human adenovirus C (see ADENOVIRUSES, HUMAN).Immunization, Secondary: Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.Chickenpox Vaccine: A live, attenuated varicella virus vaccine used for immunization against chickenpox. It is recommended for children between the ages of 12 months and 13 years.Diphtheria-Tetanus-Pertussis Vaccine: A vaccine consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and whole-cell PERTUSSIS VACCINE. The vaccine protects against diphtheria, tetanus, and whooping cough.Mumps Vaccine: Vaccines used to prevent infection by MUMPS VIRUS. Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. Children are usually immunized with measles-mumps-rubella combination vaccine.Immunization Schedule: Schedule giving optimum times usually for primary and/or secondary immunization.DNA, Viral: Deoxyribonucleic acid that makes up the genetic material of viruses.Adjuvants, Immunologic: Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.Hepatitis A Vaccines: Vaccines or candidate vaccines used to prevent infection with hepatitis A virus (HEPATOVIRUS).Genetic Therapy: Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.Adenoviruses, Porcine: Species of the genus MASTADENOVIRUS, causing neurological disease in pigs.Capsid Proteins: Proteins that form the CAPSID of VIRUSES.Mice, Inbred BALB CMeasles-Mumps-Rubella Vaccine: A combined vaccine used to prevent MEASLES; MUMPS; and RUBELLA.Aviadenovirus: A genus of ADENOVIRIDAE that infects birds. The type species is FOWL ADENOVIRUS A.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Anthrax Vaccines: Vaccines or candidate vaccines used to prevent ANTHRAX.Streptococcal Vaccines: Vaccines or candidate vaccines used to prevent STREPTOCOCCAL INFECTIONS.Gene Transfer Techniques: The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Fowl adenovirus A: The type species of the genus AVIADENOVIRUS, family ADENOVIRIDAE, an oncogenic virus of birds. This is also called CELO virus for chick embryo lethal orphan virus.Dengue Vaccines: Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.Vaccines, Virosome: Vaccines using VIROSOMES as the antigen delivery system that stimulates the desired immune response.Virus Replication: The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.Viral Hepatitis Vaccines: Any vaccine raised against any virus or viral derivative that causes hepatitis.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Poliovirus Vaccine, Oral: A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)Ebola Vaccines: Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Yellow Fever Vaccine: Vaccine used to prevent YELLOW FEVER. It consists of a live attenuated 17D strain of the YELLOW FEVER VIRUS.Plague Vaccine: A suspension of killed Yersinia pestis used for immunizing people in enzootic plague areas.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.SAIDS Vaccines: Vaccines or candidate vaccines designed to prevent SAIDS; (SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME); and containing inactivated SIMIAN IMMUNODEFICIENCY VIRUS or type D retroviruses or some of their component antigens.Fungal Vaccines: Suspensions of attenuated or killed fungi administered for the prevention or treatment of infectious fungal disease.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Viral Proteins: Proteins found in any species of virus.Neutralization Tests: The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).Rubella Vaccine: A live attenuated virus vaccine of duck embryo or human diploid cell tissue culture origin, used for routine immunization of children and for immunization of nonpregnant adolescent and adult females of childbearing age who are unimmunized and do not have serum antibodies to rubella. Children are usually immunized with measles-mumps-rubella combination vaccine. (Dorland, 28th ed)Vaccines, Acellular: Vaccines that are produced by using only the antigenic part of the disease causing organism. They often require a "booster" every few years to maintain their effectiveness.Injections, Intramuscular: Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.Receptors, Virus: Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.Influenza, Human: An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.Salmonella Vaccines: Vaccines or candidate vaccines used to prevent infection with SALMONELLA. This includes vaccines used to prevent TYPHOID FEVER or PARATYPHOID FEVER; (TYPHOID-PARATYPHOID VACCINES), and vaccines used to prevent nontyphoid salmonellosis.Vaccines, Virus-Like Particle: Vaccines using supra-molecular structures composed of multiple copies of recombinantly expressed viral structural proteins. They are often antigentically indistinguishable from the virus from which they were derived.Oncolytic Virotherapy: Use of attenuated VIRUSES as ANTINEOPLASTIC AGENTS to selectively kill CANCER cells.Oncolytic Viruses: Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.Administration, Intranasal: Delivery of medications through the nasal mucosa.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Oncogene Proteins, Viral: Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.Genes, Viral: The functional hereditary units of VIRUSES.Transduction, Genetic: The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.Keratoconjunctivitis: Simultaneous inflammation of the cornea and conjunctiva.Staphylococcal VaccinesAntibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Diphtheria-Tetanus-acellular Pertussis Vaccines: Combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Hemagglutination Inhibition Tests: Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.Cytomegalovirus Vaccines: Vaccines or candidate vaccines used to prevent infection with CYTOMEGALOVIRUS.Immunization Programs: Organized services to administer immunization procedures in the prevention of various diseases. The programs are made available over a wide range of sites: schools, hospitals, public health agencies, voluntary health agencies, etc. They are administered to an equally wide range of population groups or on various administrative levels: community, municipal, state, national, international.Immunity, Humoral: Antibody-mediated immune response. Humoral immunity is brought about by ANTIBODY FORMATION, resulting from TH2 CELLS activating B-LYMPHOCYTES, followed by COMPLEMENT ACTIVATION.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Diphtheria-Tetanus Vaccine: A combined vaccine used to prevent infection with diphtheria and tetanus toxoid. This is used in place of DTP vaccine (DIPHTHERIA-TETANUS-PERTUSSIS VACCINE) when PERTUSSIS VACCINE is contraindicated.Poliovirus Vaccines: Vaccines used to prevent POLIOMYELITIS. They include inactivated (POLIOVIRUS VACCINE, INACTIVATED) and oral vaccines (POLIOVIRUS VACCINE, ORAL).Mice, Inbred C57BLAntigens, Viral: Substances elaborated by viruses that have antigenic activity.Escherichia coli Vaccines: Vaccines or candidate vaccines used to prevent or treat both enterotoxigenic and enteropathogenic Escherichia coli infections.West Nile Virus Vaccines: Vaccines or candidate vaccines used to prevent infection with WEST NILE VIRUS.Shigella Vaccines: Vaccines or candidate vaccines used to prevent bacillary dysentery (DYSENTERY, BACILLARY) caused by species of SHIGELLA.CD8-Positive T-Lymphocytes: A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.Serotyping: Process of determining and distinguishing species of bacteria or viruses based on antigens they share.Capsid: The outer protein protective shell of a virus, which protects the viral nucleic acid.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Conjunctivitis, Viral: Inflammation, often mild, of the conjunctiva caused by a variety of viral agents. Conjunctival involvement may be part of a systemic infection.Herpes Zoster Vaccine: An attenuated vaccine used to prevent and/or treat HERPES ZOSTER, a disease caused by HUMAN HERPESVIRUS 3.Polysorbates: Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.Injections, Intradermal: The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.Brucella Vaccine: A bacterial vaccine for the prevention of brucellosis in man and animal. Brucella abortus vaccine is used for the immunization of cattle, sheep, and goats.Immunity, Cellular: Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.Tetanus ToxoidInfluenza A Virus, H1N1 Subtype: A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Herpesvirus Vaccines: Vaccines or candidate vaccines used to prevent infection by any virus from the family HERPESVIRIDAE.Leishmaniasis Vaccines: Vaccines or candidate vaccines used to prevent infection with LEISHMANIA.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Aluminum Hydroxide: A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Transgenes: Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.Alum Compounds: Aluminum metal sulfate compounds used medically as astringents and for many industrial purposes. They are used in veterinary medicine for the treatment of ulcerative stomatitis, leukorrhea, conjunctivitis, pharyngitis, metritis, and minor wounds.Herpes Simplex Virus Vaccines: Vaccines or candidate vaccines used to prevent infection with viruses from the genus SIMPLEXVIRUS. This includes vaccines for HSV-1 and HSV-2.Diphtheria Toxoid: The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.SqualeneCross Protection: Protection conferred on a host by inoculation with one strain or component of a microorganism that prevents infection when later challenged with a similar strain. Most commonly the microorganism is a virus.Respiratory Syncytial Virus Vaccines: Vaccines or candidate vaccines used to prevent infection with RESPIRATORY SYNCYTIAL VIRUSES.Interferon-gamma: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.Defective Viruses: Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.T-Lymphocytes, Cytotoxic: Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.Cytopathogenic Effect, Viral: Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Cell Transformation, Viral: An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Japanese Encephalitis Vaccines: Vaccines or candidate vaccines used to prevent infection with Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE).Mass Vaccination: Administration of a vaccine to large populations in order to elicit IMMUNITY.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Vaccines, Contraceptive: Vaccines or candidate vaccines used to prevent conception.Macaca mulatta: A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Rotavirus Infections: Infection with any of the rotaviruses. Specific infections include human infantile diarrhea, neonatal calf diarrhea, and epidemic diarrhea of infant mice.Genome, Viral: The complete genetic complement contained in a DNA or RNA molecule in a virus.Virus Cultivation: Process of growing viruses in live animals, plants, or cultured cells.Vaccines, Edible: Vaccines or candidate vaccines derived from edible plants. Transgenic plants (PLANTS, TRANSGENIC) are used as recombinant protein production systems and the edible plant tissue functions as an oral vaccine.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Immunotherapy, Active: Active immunization where vaccine is administered for therapeutic or preventive purposes. This can include administration of immunopotentiating agents such as BCG vaccine and Corynebacterium parvum as well as biological response modifiers such as interferons, interleukins, and colony-stimulating factors in order to directly stimulate the immune system.Gastroenteritis: INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Helper Viruses: Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. Helper and satellite may be of the same or different genus.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Vaccinia virus: The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Immunity, Mucosal: Nonsusceptibility to the pathogenic effects of foreign microorganisms or antigenic substances as a result of antibody secretions of the mucous membranes. Mucosal epithelia in the gastrointestinal, respiratory, and reproductive tracts produce a form of IgA (IMMUNOGLOBULIN A, SECRETORY) that serves to protect these ports of entry into the body.CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Disease Outbreaks: Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.Pseudorabies Vaccines: Vaccines or candidate vaccines used to prevent PSEUDORABIES (Aujeszky's disease), a herpesvirus of swine and other animals.Antigens, Protozoan: Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.beta-Galactosidase: A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-galactosides. Deficiency of beta-Galactosidase A1 may cause GANGLIOSIDOSIS, GM1.Gene Expression Regulation, Viral: Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Whooping Cough: A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Dendritic Cells: Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).Haplorhini: A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).Dose-Response Relationship, Immunologic: A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.Enterovirus: A genus of the family PICORNAVIRIDAE whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated "human enterovirus".Vaccine Potency: The relationship between an elicited ADAPTIVE IMMUNE RESPONSE and the dose of the vaccine administered.Cell Line, Tumor: A cell line derived from cultured tumor cells.Influenza A Virus, H5N1 Subtype: A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 1. The H5N1 subtype, frequently referred to as the bird flu virus, is endemic in wild birds and very contagious among both domestic (POULTRY) and wild birds. It does not usually infect humans, but some cases have been reported.Measles: A highly contagious infectious disease caused by MORBILLIVIRUS, common among children but also seen in the nonimmune of any age, in which the virus enters the respiratory tract via droplet nuclei and multiplies in the epithelial cells, spreading throughout the MONONUCLEAR PHAGOCYTE SYSTEM.Epitopes, T-Lymphocyte: Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.Influenza B virus: Species of the genus INFLUENZAVIRUS B that cause HUMAN INFLUENZA and other diseases primarily in humans. Antigenic variation is less extensive than in type A viruses (INFLUENZA A VIRUS) and consequently there is no basis for distinct subtypes or variants. Epidemics are less likely than with INFLUENZA A VIRUS and there have been no pandemics. Previously only found in humans, Influenza B virus has been isolated from seals which may constitute the animal reservoir from which humans are exposed.Cercopithecus aethiops: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.Rickettsial Vaccines: Vaccines for the prevention of diseases caused by various species of Rickettsia.Smallpox: An acute, highly contagious, often fatal infectious disease caused by an orthopoxvirus characterized by a biphasic febrile course and distinctive progressive skin eruptions. Vaccination has succeeded in eradicating smallpox worldwide. (Dorland, 28th ed)RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Parainfluenza Vaccines: Vaccines or candidate vaccines used to prevent infection with parainfluenza viruses in humans and animals.Respiratory Tract Infections: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
(1/6) A novel chimpanzee adenovirus vector with low human seroprevalence: improved systems for vector derivation and comparative immunogenicity.

 (+info)

(2/6) Circumventing antivector immunity by using adenovirus-infected blood cells for repeated application of adenovirus-vectored vaccines: proof of concept in rhesus macaques.

Adenovirus has been extensively exploited as a vector platform for delivering vaccines. However, preexisting antiadenovirus immunity is the major stumbling block for application of adenovirus-vectored vaccines. In this study, we found that freshly isolated peripheral blood mononuclear cells (PBMCs), mostly CD14(+) cells, from adenovirus serotype 5 (Ad5)-seropositive primates (humans and rhesus macaques) can be efficiently infected with Ad5 in vitro. On the basis of this observation, a novel strategy based on adenoviral vector-infected PBMC (AVIP) immunization was explored to circumvent antivector immunity. Autologous infusion of Ad5-SIVgag-infected PBMCs elicited a strong Gag-specific cellular immune response but induced weaker Ad5-neutralizing antibody (NAb) in Ad5-seronegative macaques than in macaques intramuscularly injected with Ad5-SIVgag. Moreover, Ad5-seropositive macaques receiving multiple AVIP immunizations with Ad5-SIVenv, Ad5-SIVgag, and Ad5-SIVpol vaccines elicited escalated Env-, Gag-, and Pol-specific immune responses after each immunization that were significantly greater than those in macaques intramuscularly injected with these Ad5-SIV vaccines. After challenged intravenously with a highly pathogenic SIVmac239 virus, macaques receiving AVIP immunization demonstrated a significant reduction in viral load at both the peak time and set-point period compared with macaques without Ad5-SIV vaccines. Our study warranted further research and development of the AVIP immunization as a platform for repeated applications of adenovirus-vectored vaccines.  (+info)

(3/6) Modification of one epitope-flanking amino acid allows for the induction of friend retrovirus-specific CD8+ T cells by Adenovirus-based immunization.

 (+info)

(4/6) Targeting the genital tract mucosa with a lipopeptide/recombinant adenovirus prime/boost vaccine induces potent and long-lasting CD8+ T cell immunity against herpes: importance of MyD88.

 (+info)

(5/6) Incidence of acute respiratory illnesses among enlisted service members during their first year of military service: did the 2011 resumption of adenovirus vaccination of basic trainees have an effect?

This study analyzed the incidence of acute respiratory illnesses (i.e., upper respiratory illnesses, bronchitis and bronchiolitis, and pneumonias) during the first 12 months of service among enlisted members of the active components of the U.S. Armed Forces. Subjects were assigned to cohorts designated 1999 through 2012 corresponding to the years during which they entered service. The objective was to determine if the late 2011 resumption of administration of adenovirus vaccines to basic trainees was associated with a reduction in acute respiratory illnesses among the 2012 cohort. Because acute respiratory illness rates were considerably higher during the first three months than the rest of the first year of service, rates during the first three months and the next nine months of service were compared separately among the cohorts. In the 2012 compared to the prior year cohorts, incidence rates of hospitalizations for pneumonia and of outpatient diagnoses of the other two acute respiratory illness types of interest were lower during the first three months but not the next nine months of enlisted service. The findings suggest a protective effect of adenovirus vaccines during recruit training. Reasons for cautious interpretation of the results are discussed.  (+info)

(6/6) A single intraduodenal administration of human adenovirus 40 vaccine effectively prevents anaphylactic shock.

 (+info)

*  DNA vaccination
Second generation vaccines were developed to reduce the risks from live vaccines. These are subunit vaccines, consisting of ... adenovirus tripartite leader (TPL) sequences and modifications to the polyadenylation and transcriptional termination sequences ... First generation vaccines are whole-organism vaccines - either live and weakened, or killed forms. Live, attenuated vaccines, ... A veterinary DNA vaccine to protect horses from West Nile virus has been approved. DNA vaccines elicit the best immune response ...
*  HIV vaccine
Adenoviruses are among the main causes of upper respiratory tract ailments such as the common cold. Because the vaccine ... Vaccine Research Center (VRC)- Information concerning Preventive HIV vaccine research studies NIAID HIV vaccine site (DAIDS) ... Global Alliance for Vaccines and Immunization (GAVI) International AIDS Vaccine Initiative (IAVI) AIDS Vaccine Advocacy ... Adenovirus vectors and many other viral vectors currently used in HIV vaccines, will induce a rapid memory immune response ...
*  Adenovirus vaccine
An adenovirus vaccine is a vaccine against Adenovirus. It was used by the United States military from 1971 to 1999, but was ... "Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune ... Vaccine. 24 (15): 2835-42. PMC 1955759 . PMID 16480793. doi:10.1016/j.vaccine.2005.12.062. "Vaccine Trials For "Boot Camp Crud ... It should not be confused with the strategy of using adenovirus as a carrier to develop vaccines for other pathogens, or as a ...
*  Julie McElrath
NIAID HIV Vaccine Trials Network. Safety and Immunogenicity of a Recombinant Adenovirus Serotype 35-Vectored HIV-1 Vaccine in ... and the NIAID HIV Vaccine Trials Network. HIV-DNA priming alters T-cell response to HIV-adenovirus vaccine even when responses ... Trivalent Adenovirus Type 5 HIV Recombinant Vaccine Primes for Modest Cytotoxic Capacity That Is Greatest in Humans with ... In 2007, she co-founded the Vaccine Infectious Disease Institute at Fred Hutch and has served as sole director of the Vaccine ...
*  Marburg virus disease
"Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges". Virology. 353 (2): ... There are currently no Food and Drug Administration-approved vaccines for the prevention of MVD. Many candidate vaccines have ... "Marburg virus vaccines: Comparing classical and new approaches". Vaccine. 20 (3-4): 586-593. doi:10.1016/S0264-410X(01)00353-X ... Vaccine. 22 (25-26): 3495-3502. doi:10.1016/j.vaccine.2004.01.063. PMID 15308377. Hevey, M.; Negley, D.; Vanderzanden, L.; ...
*  List of vaccine topics
Adenovirus vaccine Coxsackie B virus vaccine Cytomegalovirus vaccine Dengue vaccine for humans Eastern Equine encephalitis ... vaccine West Nile virus vaccine for humans Zika fever Caries vaccine Ehrlichiosis vaccine Leprosy vaccine Lyme disease vaccine ... virus vaccine for humans Ebola vaccine Enterovirus 71 vaccine Epstein-Barr vaccine Hepatitis C vaccine HIV vaccine HTLV-1 T- ... aureus vaccine Streptococcus pyogenes vaccine Syphilis vaccine Tularemia vaccine Yersinia pestis vaccine Malaria vaccine ...
*  WI-38
... cells are used to produce several vaccines including Adenovirus, MMR and Varicella zoster. Infected WI-38 cells secrete ... Over a billion vaccine doses worldwide can be traced to work done on WI-38, covering conditions including measles and rubella. ... Fetal tissue in vaccines "WI-38 (ATCC® CCL-75™)". Hayflick, Leonard (March 1965). "The Limited in vitro Lifetime of Human ... Researchers in labs across the globe have since used WI-38 in their discoveries, most notably in the development of vaccines. ...
*  HIV Vaccine Trials Network
"Status of NIAID Adenovirus-based Vaccine Studies". NIAID. Archived from the original on 2008-10-01. Retrieved 2008-10-29. ... The vaccine contained no HIV and no one could have contracted HIV from the vaccine, but there was intense discussion as to ... The experimental vaccine used in this study was developed by the Vaccine Research Center at the National Institutes of Health ( ... The HVTN is a network for testing vaccines, and while its members may also work in vaccine development for other entities, the ...
*  List of cocaine analogues
"Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing ... "Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs". Mol ... Schabacker, DS; Kirschbaum, KS; Segre, M (2000). "Exploring the feasibility of an anti-idiotypic cocaine vaccine: analysis of ...
*  Adenovirus infection
Safe and effective adenovirus vaccines were developed for adenovirus serotypes 4 and 7, but were available only for preventing ... 2000). "Adult adenovirus infections: loss of orphaned vaccines precipitates military respiratory disease epidemics". Clin ... Enteric adenoviruses 40 and 41 cause gastroenteritis, usually in children. For some adenovirus serotypes, the clinical spectrum ... adenovirus infections can occur throughout the year. "Ad14 (for adenovirus serotype 14), has caused at least 140 illnesses in ...
*  Adenoviridae
Currently, there is no adenovirus vaccine available to the general public, but a vaccine is available for the United States ... Adenoviruses Stanford University - Adenoviruses Adenoviruses General Concepts General information on Adenovirus DNA virus ... Tupaia adenovirus (TAV) (Tree shrew adenovirus 1) has been isolated from tree shrews. Otarine adenovirus 1 has been isolated ... Matrix protein M1 on the platform of the adenovirus dodecahedron". Vaccine. 27 (52): 7385-7393. doi:10.1016/j.vaccine.2009.09. ...
*  Viral vector
Adenoviruses are being actively developed as vaccines. Retroviruses are one of the mainstays of current gene therapy approaches ... If the vaccine or gene therapy fails in clinical trials, the virus can't be used again in the patient for a different vaccine ... A viral vaccine induces expression of pathogen proteins within host cells similarly to the Sabin Polio vaccine and other ... "Impact of Preexisting Adenovirus Vector Immunity on Immunogenicity and Protection Conferred with an Adenovirus-Based H5N1 ...
*  Maurice Green (virologist)
... but it also raised concerns because the military was using live adenoviruses as vaccines against adenovirus-induced acute ... Doerfler, W. (2012-12-06). The Molecular Biology of Adenoviruses I: 30 Years of Adenovirus Research 1953-1983. Springer Science ... and determining the molecular and kinetic parameters of adenovirus infection. He showed that adenoviruses could be divided into ... HUEBNER (1963). "Specific Adenovirus Complement-Fixing Antigens in Virus-Free Hamster and Rat Tumors". Proceedings from the ...
*  CAd3-ZEBOV
This vaccine is derived from a chimpanzee adenovirus, Chimp Adenovirus type 3 (ChAd3), genetically engineered to express ... cAd3-ZEBOV (also known as the NIAID/GSK Ebola vaccine or cAd3-EBO Z) is an experimental vaccine for two ebolaviruses, Ebola ... First volunteer receives new Ebola vaccine in UK trial First British volunteer injected with trial Ebola vaccine in Oxford, The ... "Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, ...
*  Infectious canine hepatitis
Most combination vaccines for dogs contain a modified canine adenovirus type-2. CAV-2 is one of the causes of respiratory ... CAV-2 vaccine is much less likely to cause side effects than CAV-1 vaccine. One study has shown the vaccine to have a duration ... Infectious canine hepatitis is an acute liver infection in dogs caused by canine adenovirus type-1 (CAV-1). CAV-1 also causes ... Prevention is through vaccination (ATCvet code QI07AA05 (WHO) and various combination vaccines). ...
*  Enadenotucirev
It is an oncolytic A11/Ad3 Chimeric Group B Adenovirus, previously described as oncolytic vaccine ColoAd1. It is intended to be ... Oncolytic adenovirus Oncolytic adenovirus#Directed Evolution PsiOxus Therapeutics Initiates Combination Study of Merck's ... Dec 2015 PsiOxus Therapeutics announces positive study results of oncolytic vaccine enadenotucirev at 2014 ASCO annual meeting ... Ovarian cancer oncolytic vaccine receives positive reviews. an 2015 Enadenotucirev trials Phase I / II Study of Enadenotucirev ...
*  Ebola vaccine
24 March 2015). "Safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine in healthy ... The regimen consists of two vaccine components (first vaccine as prime, followed by a second vaccine as boost) that are based ... The new vaccine relies on a strain of Ebola called EBOVΔVP30, which is unable to replicate. A study published in Human Vaccines ... doi:10.1016/j.vaccine.2016.10.004. ISSN 1873-2518. PMID 27751640. Pavot, Vincent (December 2016). "Ebola virus vaccines: Where ...
*  Robert M. Chanock
Researchers working with Chanock developed vaccines to prevent adenovirus infection, Hepatitis A and rotavirus, the most common ... Efforts were underway to create a vaccine to deal with dengue fever, though efforts to create immunizations for para-influenza ... cause of severe diarrhoea in infants and young children, as well as an influenza virus vaccine in the form of a nasal spray. ...
*  Kennel cough
Several intranasal vaccines have been developed that contain canine adenovirus in addition to B bronchiseptica and canine- ... To increase their effectiveness, vaccines should be administered as soon as possible after a dog enters a high-risk area, such ... Edinboro, C; Ward, M; Glickman, L (February 2004). "A Placebo-controlled Trial of Two Intranasal Vaccines to Prevent ... Prevention is by vaccinating for canine adenovirus, distemper, parainfluenza, and Bordetella. In kennels, the best prevention ...
*  Agamid adenovirus
As of this revision of this article no vaccine, treatment or cure for Agamid Adenovirus 1 has been found. "Adeno Knowledgebase ... June 1999 Adenoviruses in Reptiles, Melissa Kaplan, 2000 Promoting healthier adenovirus free bearded dragons, The Pogona ... "Cheri Smith on "Adenovirus Symptoms"". Archived from the original on 2008-05-12. Kubber-Heiss, A; Benetka, V; Filip, T, et al. ... Agamid adenovirus (Agamid AdV1) is a type of virus in the Adenoviridae family. The virus is widespread in captive populations ...
*  Bovine adenovirus
The vaccine is not available worldwide. Bovine Adenovirus, reviewed and published by WikiVet at http://en.wikivet.net/Bovine ... Bovine Adenovirus, also known as BAdV, is a member of the Adenoviridae family that causes disease in cattle. There are 10 ... Virus isolation is the only way to identify the serotype of the adenovirus. Postmortem examination may reveal lesions in the ...
*  Genetically modified virus
... dengue fever and viral hepatitis by using a proven safe vaccine virus, such as adenovirus, and modify its genome to have genes ... In 2001, it was reported that genetically modified viruses can possibly be used to develop vaccines against diseases such as, ... Viruses that have been used for gene therapy are, adenovirus, lentivirus, retrovirus and the herpes simplex virus. Although ... Stephenson, J. R. (March 2001). "Genetically modified viruses: vaccines by design". Current Pharmaceutical Biotechnology. 2 (1 ...
*  DA2PPC vaccine
While the DA2PPC vaccine also protects against parainfluenza, parvovirus, adenovirus, and canine coronavirus, it most ... This vaccine is usually given to puppies at 8 weeks of age, followed by 12 weeks of age, and then 16 weeks of age. This vaccine ... Distemper, adenovirus type 1 (thus hepatitis), parainfluenza, and parvovirus are covered by all 4. DHPP covers adenovirus type ... all reputable veterinarians recommend the DA2PPC vaccine. Also, even if the dog owner is not concerned about adenovirus, ...
*  Oncolytic adenovirus
Traditional research has focussed on species C Adenovirus serotype 5 (Ad5) for creating oncolytic vaccines for the potential ... Adenoviruses have so far been through three generations of development. Some of the strategies for modification of adenoviruses ... and the knob domain of the adenovirus coat protein trimer. CAR is necessary for adenovirus infection. Although expressed widely ... Adenovirus varieties have been explored extensively as a viral vector for gene therapy and also as an oncolytic virus. Of the ...
*  Cell culture
Novel ideas in the field include recombinant DNA-based vaccines, such as one made using human adenovirus (a common cold virus) ... The injectable polio vaccine developed by Jonas Salk was one of the first products mass-produced using cell culture techniques ... This vaccine was made possible by the cell culture research of John Franklin Enders, Thomas Huckle Weller, and Frederick ... Vaccines for polio, measles, mumps, rubella, and chickenpox are currently made in cell cultures. Due to the H5N1 pandemic ...
*  Robert Huebner
Robert M. Chanock said the discovery "put him up there with Sabin" (creator of the oral polio vaccine) as one of the "great ... From that culture they isolated cytomegalovirus, as well as the first of a large family of adenoviruses. Dr. ... Research on retroviruses led to the development of a vaccine for hepatitis B, which has led to major decreases in rates of ...
*  Avian adenovirus
Vaccines for HE and EDS are available (ATCvet codes: QI01AA05 (WHO) for the inactivated vaccine, QI01AD05 (WHO) for the live ... Adenoviruses, accessed 18/08/2011. Adenovirus Taxonomy 2005 Diagnosis of Adenovirus Infections in Psittacine Birds by DNA in ... Falcon adenovirus A and Inclusion Body Hepatitis (IBH). Avian adenoviruses have a worldwide distribution and it is common to ... Aviadenoviruses are adenoviruses that affect birds - particularly chickens, ducks, geese, turkeys and pheasants. There are ...
Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity...  Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity...
We investigated whether the two vaccine compon ents adenovirus (Ad) and MVA could be coinjected as a mixture to enhance ... We investigated whether the two vaccine compon ents adenovirus (Ad) and MVA could be coinjected as a mixture to enhance ... Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity ... Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity ...
more infohttps://www.paediatrics.ox.ac.uk/publications/348832
Vax Report - Understanding How Immune Responses to AIDS Vaccine Candidates are Measured  Vax Report - Understanding How Immune Responses to AIDS Vaccine Candidates are Measured
... preventive HIV vaccines for use throughout the world. ... The International AIDS Vaccine Initiative (IAVI) is a global ... For instance, in the recently conducted STEP trial that tested Merck's adenovirus serotype 5-based vaccine candidate, the ... Understanding How Immune Responses to AIDS Vaccine Candidates are Measured What are the limitations of current methods used to ... The ELISPOT assay is used to detect secretion of a single cytokine by both CD4+ and CD8+ T cells that are induced by a vaccine ...
more infohttp://vaxreport.org/vax-february-2009/622-understanding-how-immune-responses-to-aids-vaccine-candidates-are-measured
Adenovirus vaccine - Wikipedia  Adenovirus vaccine - Wikipedia
An adenovirus vaccine is a vaccine against Adenovirus. It was used by the United States military from 1971 to 1999, but was ... "Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune ... Vaccine. 24 (15): 2835-42. PMC 1955759 . PMID 16480793. doi:10.1016/j.vaccine.2005.12.062. "Vaccine Trials For "Boot Camp Crud ... It should not be confused with the strategy of using adenovirus as a carrier to develop vaccines for other pathogens, or as a ...
more infohttps://en.wikipedia.org/wiki/Adenovirus_vaccine
British Library EThOS: Novel adenovirus vaccine vectors  British Library EThOS: Novel adenovirus vaccine vectors
Replication defective adenoviruses have emerged as promising vectors for delivery of vaccine antigens. The development of new ... This thesis describes the construction and optimisation of ChAdOX1, a new vector based on chimpanzee adenovirus Y2S, which has ... Aft intramuscular administration, HAdV-S (Human adenovirus C) based vectors elicited superior transgene product specific T cell ... and antibody responses compared to a selection of chimpanzee adenovirus vectors (from Human adenovirus EJ including ChAdOX1. ...
more infohttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599909
Adenovirus Vaccine, Live (Oral Route) Description and Brand Names - Mayo Clinic  Adenovirus Vaccine, Live (Oral Route) Description and Brand Names - Mayo Clinic
Adenovirus type 4 and type 7 live vaccine is used to prevent febrile (with fever) acute respiratory disease (ARD) caused by ... This vaccine is to be administered only by or under the supervision of your doctor or other health care professional. ... This vaccine is given to military personnels 17 to 50 years of age. ... adenovirus type 4 and type 7. It works by causing your body to produce its own protection (antibodies) against the virus. ...
more infohttps://www.mayoclinic.org/drugs-supplements/adenovirus-vaccine-live-oral-route/description/drg-20074834
Critical considerations for adenovirus-based HIV vaccine trials  Critical considerations for adenovirus-based HIV vaccine trials
... that recognized a component of the vaccine (adenovirus serotype 5 [Ad5]). ... Moreover, subsequent analyses indicated that the vaccine made some individuals more susceptible to HIV, in particular ... A clinical trial testing a candidate HIV vaccine known as the STEP study was halted in September 2007 after interim analysis ... Tags: Adenovirus, Antibodies, Cancer, Cell, Clinical Trial, HIV, HIV/AIDS, HIV-1, Immune System, Research, Vaccine ...
more infohttps://www.news-medical.net/news/20111228/Critical-considerations-for-adenovirus-based-HIV-vaccine-trials.aspx
Read eBooks online | World Heritage Encyclopedia | Adenovirus vaccine  Read eBooks online | World Heritage Encyclopedia | Adenovirus vaccine
Pneumococcal vaccine Encyclopedia Article. Vaccine, Conjugate vaccine, Pneumococcal polysaccharide vaccine, Medical Subject ... "Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune ... It should not be confused with the strategy of using adenovirus as a carrier to develop vaccines for other pathogens, or as a ... Tatsis N, Ertl HC (October 2004). "Adenoviruses as vaccine vectors". Mol. Ther. 10 (4): 616-29. ...
more infohttp://worldheritage.org/articles/eng/Adenovirus_vaccine
Enhanced Protection against Ebola Virus Mediated by an Improved Adenovirus-Based Vaccine  Enhanced Protection against Ebola Virus Mediated by an Improved Adenovirus-Based Vaccine
2009) Enhanced Protection against Ebola Virus Mediated by an Improved Adenovirus-Based Vaccine. PLoS ONE 4(4): e5308. doi: ... replication defective adenovirus-based Ebola vaccine is being studied in a phase I clinical trial. Another Ebola vaccine, based ... Enhanced Protection against Ebola Virus Mediated by an Improved Adenovirus-Based Vaccine. ... In this report, we modified the common recombinant adenovirus serotype 5-based Ebola vaccine expressing the wild-type ZEBOV ...
more infohttps://repositories.lib.utexas.edu/handle/2152/20465
Respiratory macrophages regulate CD4 T memory responses to mucosal immunization with recombinant adenovirus-based vaccines  -...  Respiratory macrophages regulate CD4 T memory responses to mucosal immunization with recombinant adenovirus-based vaccines -...
Respiratory macrophages regulate CD4 T memory responses to mucosal immunization with recombinant adenovirus-based vaccines ... in regulating CD4 T cell responses to recombinant adenovirus-based (rAd) vaccines. We demonstrated that rAd intranasal (i.n.) ... in regulating CD4 T cell responses to recombinant adenovirus-based (rAd) vaccines. We demonstrated that rAd intranasal (i.n.) ... Respiratory macrophages regulate CD4 T memory responses to mucosal immunization with recombinant adenovirus-based vaccines. ...
more infohttp://www.zora.uzh.ch/id/eprint/125320/
Phase II Study of Adenovirus/PSA Vaccine in Men With Recurrent Prostate Cancer After Local Therapy APP21 - Full Text View -...  Phase II Study of Adenovirus/PSA Vaccine in Men With Recurrent Prostate Cancer After Local Therapy APP21 - Full Text View -...
Phase II Study of Adenovirus/PSA Vaccine in Men With Recurrent Prostate Cancer After Local Therapy APP21 (APP21). The safety ... Clinical protocol: phase I study of an adenovirus/prostate-specific antigen vaccine in men with metastatic prostate cancer. Hum ... Phase II Study of Adenovirus/PSA Vaccine in Men With Recurrent Prostate Cancer After Local Therapy. ... Biological: Adenovirus/PSA Vaccine 1x10E8pfu in Gelfoam subcutaneously on day 0, 30, 60 ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00583752?recr=Open&cond=%22Adenoviridae+Infections%22&rank=18
Definition of adenovirus-PSA prostate cancer vaccine - NCI Drug Dictionary - National Cancer Institute  Definition of adenovirus-PSA prostate cancer vaccine - NCI Drug Dictionary - National Cancer Institute
Upon subcutaneous vaccination with the adenovirus-PSA prostate cancer vaccine, the adenovirus infects cells and expresses PSA. ... replication-deficient type 5 adenovirus carrying the human prostate-specific antigen (PSA), with potential immunostimulating ... A cancer vaccine composed of a genetically engineered, ... adenovirus-PSA prostate cancer vaccine A cancer vaccine ... Upon subcutaneous vaccination with the adenovirus-PSA prostate cancer vaccine, the adenovirus infects cells and expresses PSA. ...
more infohttps://www.cancer.gov/publications/dictionaries/cancer-drug/def/adenovirus-psa-prostate-cancer-vaccine
Oral Modeling of an Adenovirus-Based Quadrivalent Influenza Vaccine in Ferrets and Mice | SpringerLink  Oral Modeling of an Adenovirus-Based Quadrivalent Influenza Vaccine in Ferrets and Mice | SpringerLink
Introduction Oral vaccines delivered as tablets offer a number of advantages over traditional parenteral-based vaccines ... N = 10 for Ad vaccine groups. N = 4 for TIV vaccine. Ad adenovirus, CI confidence interval, ELISA enzyme-linked immunosorbent ... The various vaccine combinations were tested by blending monovalent recombinant adenovirus vaccines, each expressing ... We have been developing an oral-based adenovirus platform for vaccine delivery. The vaccine platform consists of a replication- ...
more infohttps://link.springer.com/article/10.1007%2Fs40121-016-0108-z
Evaluating the Safety and Immune Response of an Adenovirus-Based HIV Vaccine in HIV-Uninfected Adults - Full Text View -...  Evaluating the Safety and Immune Response of an Adenovirus-Based HIV Vaccine in HIV-Uninfected Adults - Full Text View -...
Received HIV vaccine(s) in a prior HIV vaccine trial. Participants who received a control/placebo in an HIV vaccine trial are ... Participants will be randomly assigned to receive either the rAd26 vaccine or a placebo vaccine. All vaccines will be injected ... Evaluating the Safety and Immune Response of an Adenovirus-Based HIV Vaccine in HIV-Uninfected Adults. The safety and ... Many HIV preventive vaccines that are in development use a recombinant adenovirus serotype 5 (rAd5) vector as a way of ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01103687?term=%22+March+17%2C++2010%22%3A%22+April+16%2C++2010%22%5BFIRST-RECEIVED-DATE%5DAND+HIV%5BCONDITION%5D&rank=15
Adenovirus Type 4 and Type 7 Vaccine, Live, Oral  Adenovirus Type 4 and Type 7 Vaccine, Live, Oral
Proper Name: Adenovirus Type 4 and Type 7 Vaccine, Live, Oral. Trade Name: None. Manufacturer: Barr Labs, Inc.. Indication: ... October 20, 2014 Approval Letter - Adenovirus Type 4 and Type 7 Vaccine, Live, Oral. To revise the package insert to remove ... Package Insert - Adenovirus Type 4 and Type 7 Vaccine, Live, Oral. (PDF - 129KB) ... Approval History, Letters, Reviews and Related Documents - Adenovirus Type 4 and Type 7 Vaccine, Live, Oral (ZIP - 1.5MB) ...
more infohttps://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm247508.htm
A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose...  A simian-adenovirus-vectored rabies vaccine suitable for thermostabilisation and clinical development for low-cost single-dose...
Here, we report the development of a new candidate rabies vaccine, designed to enable low-cost single-dose pre-exposure human ... ChAdOx2 RabG is based upon a simian adenovirus-vectored candidate previously shown to achieve protection after a single dose in ... Although it is eminently preventable, with highly efficacious vaccines available for both humans and animals, it still causes ... the second human disease for which an efficacious vaccine was developed, by Pasteur in 1885. ...
more infohttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006870
Improved Efficacy of a Gene Optimised Adenovirus-based Vaccine for Venezuelan Equine Encephalitis Virus | Virology Journal |...  Improved Efficacy of a Gene Optimised Adenovirus-based Vaccine for Venezuelan Equine Encephalitis Virus | Virology Journal |...
We have applied this to an adenovirus (ad)-based vaccine encoding structural proteins (E3-E2-6K) of Venezuelan equine ... informs us that including optimised genes in gene-based vaccines for VEEV is essential to obtain maximum immunogenicity and ... encephalitis virus (VEEV). Following administration of this vaccine to Balb/c mice, an approximately ten-fold increase in ... antibody response was elicited and increased protective efficacy compared to an ad-based vaccine containing non-optimised genes ...
more infohttps://virologyj.biomedcentral.com/articles/10.1186/1743-422X-6-118
Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein |...  Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein |...
Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein. ... Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein ... Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein ... Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein ...
more infohttps://www.jimmunol.org/content/174/11/7179.abstract
A Monovalent Chimpanzee Adenovirus Ebola Vaccine  A Monovalent Chimpanzee Adenovirus Ebola Vaccine
... - Preliminary Report of the experimental monovalent ChAd3 vaccine against EBOV ... The n e w e ng l a n d j o u r na l of m e dic i n e original article A Monovalent Chimpanzee Adenovirus Ebola Vaccine - ... A vaccine could contribute to outbreak control in the region. We assessed a monovalent formulation of a chimpanzee adenovirus 3 ... A Monovalent Chimpanzee Adenovirus Ebola Vaccine - Preliminary Report A Day 28 B Day 28 CD4+ CD8+ P=0.001 100 CD107a ...
more infohttp://exploredoc.com/doc/187295/a-monovalent-chimpanzee-adenovirus-ebola-vaccine
A Human Type 5 Adenovirus-Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti...  A Human Type 5 Adenovirus-Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti...
An adenovirus-based TB vaccine elicits T cell immunogenicity despite preexisting anti-AdHu5 immunity in people. ... An adenovirus-based TB vaccine elicits T cell immunogenicity despite preexisting anti-AdHu5 immunity in people. ... AdHu5Ag85A is a recombinant human type 5 adenovirus (AdHu5)-based TB vaccine with demonstrated efficacy in a number of animal ... A Human Type 5 Adenovirus-Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti- ...
more infohttp://stm.sciencemag.org/content/5/205/205ra134
The generation and analysis of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an...  The generation and analysis of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an...
The generation and analysis of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an ... Ad5 [E1-, E2b-]-CEA vaccine (ETBX-011) has been employed in clinical studies as an active vaccine to induce immune responses to ... We report here the development of novel Ad5 [E1-, E2b-]-brachyury and Ad5 [E1-, E2b-]-MUC-1 vaccine constructs. The Ad5 [E1-, ... We have also demonstrated that the use of a combination of the three vaccines (designated Tri-Ad5) displays little, if any, ...
more infohttps://jitc.biomedcentral.com/articles/10.1186/2051-1426-3-S2-P452
  • Understanding and improving the molecular components of adenovirus-based vaccines can produce potent, optimized product, useful for vaccination and post-exposure therapy. (utexas.edu)
  • Upon subcutaneous vaccination with the adenovirus-PSA prostate cancer vaccine, the adenovirus infects cells and expresses PSA. (cancer.gov)
  • Vaccination is an effective way of reducing the numbers of infected individuals provided there is a good match between the vaccine and the circulating strains. (springer.com)
  • We have also demonstrated that the use of a combination of the three vaccines (designated Tri-Ad5) displays little, if any, antigenic competition in in vitro studies of human dendritic cells for antigen-specific T cell activation and generation, or in murine vaccination studies. (biomedcentral.com)
  • The study and characterization of recombinant adenovirus (Ad) vaccine platforms, particularly Ad serotype 5 (Ad5) vaccine platforms, are of great interest for their development and clinical application for human vaccination. (asm.org)
  • Alternatively, it is possible to bypass AdHu5 PEI by altering the route of vaccine delivery from the conventional intramuscular (i.m.) injection which typically stimulates systemic responses ( 10 , 20 , 28 ) to an airway route of vaccination capable of inducing both mucosal and systemic immune responses in both the mouse and guinea pig animal models ( 29 - 33 ). (asm.org)
  • After contracting a new manufacturer, adenovirus vaccination of military basic trainees resumed in 2011. (utexas.edu)
  • Two decision tree models comparing adenovirus vaccination to no adenovirus vaccination were used for this dissertation. (utexas.edu)
  • Results from part I indicated that adenovirus vaccination of basic trainees was cost-effective as measured by FRI hospitalizations prevented in all US military service branches but the Coast Guard. (utexas.edu)
  • In part II of this study, adenovirus vaccination of basic trainees was the dominant strategy as measured by TDL averted in all US military service branches but the Marine Corps and the Coast Guard. (utexas.edu)
  • She continues to be involved in a global initiative to develop an HIV-1 vaccine, and in research to identify innate and mucosal immune defenses generated following vaccination. (wikipedia.org)
  • Prevention is through vaccination (ATCvet code QI07AA05 (WHO) and various combination vaccines). (wikipedia.org)
  • The administration of vaccines is called vaccination. (wikipedia.org)
  • The terms vaccine and vaccination are derived from Variolae vaccinae (smallpox of the cow), the term devised by Edward Jenner to denote cowpox. (wikipedia.org)
  • The efficacy or performance of the vaccine is dependent on a number of factors: the disease itself (for some diseases vaccination performs better than for others) the strain of vaccine (some vaccines are specific to, or at least most effective against, particular strains of the disease) whether the vaccination schedule has been properly observed. (wikipedia.org)
  • The following are important considerations in the effectiveness of a vaccination program:[citation needed] careful modeling to anticipate the impact that an immunization campaign will have on the epidemiology of the disease in the medium to long term ongoing surveillance for the relevant disease following introduction of a new vaccine maintenance of high immunization rates, even when a disease has become rare. (wikipedia.org)
  • Methods After expedited regulatory and ethics approvals, 60 healthy adult volunteers in Oxford, United Kingdom, received a single dose of the ChAd3 vaccine at one of three dose levels: 1×1010 viral particles, 2.5×1010 viral particles, and 5×1010 viral particles (with 20 participants per group). (exploredoc.com)
  • In studies comparing these two types of Ads, Ad5[E1−,E2b−] vaccines have been found to promote the decreased expression of viral proteins, persist longer in vivo , and induce less virus-associated toxicity following in vivo administration ( 16 , 28 , 29 ). (asm.org)
  • Preclinical studies of viral vector-based HIV-1 vaccine candidates have previously shown partial protection against neutralization-resistant virus challenges in rhesus monkeys. (jpt.com)
  • HVTN 505 is a project to examine whether a particular DNA prime/boost vaccine regimen will reduce viral load in individuals who later become infected with HIV. (wikipedia.org)
  • In 2001, it was reported that genetically modified viruses can possibly be used to develop vaccines against diseases such as, AIDS, herpes, dengue fever and viral hepatitis by using a proven safe vaccine virus, such as adenovirus, and modify its genome to have genes that code for immunogenic proteins that can spike the immune systems response to then be able to fight the virus. (wikipedia.org)
  • Adenovirus varieties have been explored extensively as a viral vector for gene therapy and also as an oncolytic virus. (wikipedia.org)
  • For adenovirus replication to occur, the host cell must be induced into S phase by viral proteins interfering with cell cycle proteins. (wikipedia.org)
  • M. Juliana "Julie" McElrath (born January 9, 1951) is a senior vice president and director of the vaccine and infectious disease division at Fred Hutchinson Cancer Research Center and principal investigator of the HIV Vaccine Trials Network Laboratory Center in Seattle, Washington. (wikipedia.org)
  • Over time, she became a full professor at the University of Washington a full member at Fred Hutch, and the director of the HIV Vaccine Trials Network (HTVN) Laboratory Center. (wikipedia.org)
  • At the HVTN, many current vaccine studies are using products with a safety record that has been established in previous human trials. (wikipedia.org)
  • In 2003 the HVTN partnered with Harvard University in establishing a small-scale vaccine trials unit in Botswana. (wikipedia.org)
  • A major reason for this project was gathering data about the prevalence of HIV in Africa and assessing the feasibility of getting grassroots support for vaccine trials in non-American culture. (wikipedia.org)
  • In 2007 HVTN started the first large-scale HIV vaccine trials in Africa, with financial assistance from the SA Aids Vaccine Initiative. (wikipedia.org)
  • One of those trials begun in 2007, the Phambili Trial, was halted in 2007 due to its similarity to the ineffective vaccine used in the American STEP study. (wikipedia.org)
  • Simultaneous phase 1 trials of this vaccine commenced in September 2014, being administered to volunteers in Oxford and Bethesda. (wikipedia.org)
  • Early vaccines may be listed by the first year of development or testing, but later entries usually show the year the vaccine finished trials and became available on the market. (wikipedia.org)
  • Simian virus 40 (SV40) was an accidental contaminant of vaccines produced in monkey kidney tissue cultures in the 1950s and early 1960s, including a parenteral adenovirus vaccine given to several hundred thousand US military recruits. (oup.com)
  • The simian adenovirus, ChAdOx1, and modified vaccinia Ankara virus, MVA, encoding a prostate cancer-associated antigen, the six transmembrane epithelial antigen of the prostate 1 (STEAP1), induced strong sustained antigen-specific CD8+ T-cell responses in C57BL/6 and BALB/c male mice. (medworm.com)
  • Here we describe the development of a simian Ad24 (sAd24)-based vaccine vector. (biomedcentral.com)
  • Adenoviruses (members of the family Adenoviridae) are medium-sized (90-100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome. (wikipedia.org)
  • Adenoviruses represent the largest nonenveloped viruses. (wikipedia.org)
  • citation needed] Viruses expressing pathogen proteins are currently being developed as vaccines against these pathogens, based on the same rationale as DNA vaccines. (wikipedia.org)
  • Efforts were underway to create a vaccine to deal with dengue fever, though efforts to create immunizations for para-influenza viruses and respiratory syncytial virus were unsuccessful. (wikipedia.org)
  • Viruses that have been used for gene therapy are, adenovirus, lentivirus, retrovirus and the herpes simplex virus. (wikipedia.org)
  • Of the many different viruses being explored for oncolytic potential, an adenovirus was the first to be approved by a regulatory agency, the genetically modified H101 strain. (wikipedia.org)
  • Growing viruses in cell cultures allowed preparation of purified viruses for the manufacture of vaccines. (wikipedia.org)
  • There are currently eight species in this genus including the type species Fowl aviadenovirus A. Viruses in this genus cause specific disease syndromes such as Quail Bronchitis (QB), Egg Drop Syndrome (EDS), Haemorrhagic Enteritis (HE), Pheasant Marble Spleen Disease (MSD), Falcon adenovirus A and Inclusion Body Hepatitis (IBH). (wikipedia.org)
  • The same fibroblast cells from these pregnancies that were originally used to grow vaccine viruses have been growing in labs ever since, as the WI-38 and MRC-5 cell lines. (wikipedia.org)
  • They are still used to grow vaccine viruses today. (wikipedia.org)
  • The development of the recombinant subunit vaccine was an important and necessary development because hepatitis B virus, unlike other common viruses such as polio virus, cannot be grown in vitro. (wikipedia.org)
  • Moreover, our data suggest that future T cell-focused vaccine design should aim to induce immunodominant responses to highly conserved regions of the virus. (iavi.org)
  • A conditionally replicative adenovirus (CRAd) with a 24 base pair deletion in the retinoblastoma-binding domain of the E1A protein (Ad5- Δ24E3), is unable to silence retinoblastoma, and therefore unable to induce S-phase in host cells. (wikipedia.org)
  • It should not be confused with the strategy of using adenovirus as a carrier to develop vaccines for other pathogens, or as a general gene carrier. (wikipedia.org)
  • We have reported on a novel adenovirus serotype 5 (Ad5) vector gene delivery platform (Ad5 [E1-, E2b-]), in which regions of the early 1 (E1), early 2 (E2b), and early 3 (E3) genes have been deleted. (biomedcentral.com)
  • Some adenoviruses under specialized conditions can transform cells using their early gene products. (wikipedia.org)
  • The adenovirus E1B55kDa gene cooperates with another adenoviral product, E4ORF6, to inactivate p53, thus preventing apoptosis. (wikipedia.org)
  • It was initially proposed that an adenovirus mutant lacking the E1B55kDa gene, dl1520 (ONYX-015), could replicate selectively in p53 deficient cells. (wikipedia.org)
  • The adenovirus life cycle is separated by the DNA replication process into two phases: an early and a late phase. (wikipedia.org)
  • On 31 July 2015, preliminary results of a Phase 3 trial in Guinea indicated that the vaccine appears to be "highly efficacious and safe. (wikipedia.org)
  • No new vaccine has been first tested in humans and rapidly developed within months in an attempt to control a major infectious disease outbreak. (exploredoc.com)
  • In 2007, she co-founded the Vaccine Infectious Disease Institute at Fred Hutch and has served as sole director of the Vaccine and Infectious Disease Division at Fred Hutch since 2011. (wikipedia.org)
  • Vaccines have historically been the most effective means to fight and eradicate infectious diseases. (wikipedia.org)
  • Despite the Vatican's longstanding and complete opposition to abortion, their Pontifical Academy for Life concluded in 2005 that parents should allow their children to receive vaccines made from fetal tissue, to protect them from infectious diseases. (wikipedia.org)
  • Recombinant adenoviruses expressing the EBOV glycoprotein (GP) mixed with AdHu5 expressing the EBOV nucleoprotein (NP) offered complete protection in nonhuman primates (NHP) against lethal EBOV challenge ( 18 , 20 ). (asm.org)
  • These studies have evaluated monovalent vaccines to date. (springer.com)
  • Conclusions The ChAd3 monovalent vaccine against EBOV was immunogenic at the doses tested. (exploredoc.com)
  • The use of the monovalent formulation halves the manufacturing challenge, as compared with use of the bivalent vaccine, which includes a second vector encoding the Sudan strain glycoprotein16 with only 60% identity to the Guinea outbreak strain. (exploredoc.com)
  • The data further validate the use of the VIA to screen and select future HIV vaccine candidates. (iavi.org)
  • A combination of the vaccine with PD-1 blocking antibody significantly improved survival of the animals, with 80 % of mice remaining tumour-free. (medworm.com)
  • Vaccines have contributed to the eradication of smallpox, one of the most contagious and deadly diseases in humans. (wikipedia.org)
  • Researchers in labs across the globe have since used WI-38 in their discoveries, most notably in the development of vaccines. (wikipedia.org)