Adenovirus Vaccines: Vaccines used to prevent infection by any virus from the family ADENOVIRIDAE.Adenoviruses, Human: Species of the genus MASTADENOVIRUS, causing a wide range of diseases in humans. Infections are mostly asymptomatic, but can be associated with diseases of the respiratory, ocular, and gastrointestinal systems. Serotypes (named with Arabic numbers) have been grouped into species designated Human adenovirus A-F.Viral Vaccines: Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.Adenoviridae: A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.Adenovirus Infections, Human: Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses.Vaccines, Synthetic: Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.Genetic Vectors: DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.Vaccines: Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.Vaccines, Inactivated: Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.Adenovirus E1A Proteins: Proteins transcribed from the E1A genome region of ADENOVIRUSES which are involved in positive regulation of transcription of the early genes of host infection.Vaccines, DNA: Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.Vaccines, Combined: Two or more vaccines in a single dosage form.Adenoviridae Infections: Virus diseases caused by the ADENOVIRIDAE.Bacterial Vaccines: Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.AIDS Vaccines: Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.Adenovirus Early Proteins: Proteins encoded by adenoviruses that are synthesized prior to, and in the absence of, viral DNA replication. The proteins are involved in both positive and negative regulation of expression in viral and cellular genes, and also affect the stability of viral mRNA. Some are also involved in oncogenic transformation.Adenovirus E1B Proteins: Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression.Adenovirus E3 Proteins: Proteins transcribed from the E3 region of ADENOVIRUSES but not essential for viral replication. The E3 19K protein mediates adenovirus persistence by reducing the expression of class I major histocompatibility complex antigens on the surface of infected cells.Adenovirus E4 Proteins: Proteins transcribed from the E4 region of ADENOVIRUSES. The E4 19K protein transactivates transcription of the adenovirus E2F protein and complexes with it.Vaccines, Subunit: Vaccines consisting of one or more antigens that stimulate a strong immune response. They are purified from microorganisms or produced by recombinant DNA techniques, or they can be chemically synthesized peptides.Vaccines, Conjugate: Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.Vaccination: Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.Malaria Vaccines: Vaccines made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents.Adenovirus E1 Proteins: The very first viral gene products synthesized after cells are infected with adenovirus. The E1 region of the genome has been divided into two major transcriptional units, E1A and E1B, each expressing proteins of the same name (ADENOVIRUS E1A PROTEINS and ADENOVIRUS E1B PROTEINS).Papillomavirus Vaccines: Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.Meningococcal Vaccines: Vaccines or candidate vaccines used to prevent infection with NEISSERIA MENINGITIDIS.Hepatitis B Vaccines: Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced.Adenoviruses, Canine: Species of the genus MASTADENOVIRUS that causes fever, edema, vomiting, and diarrhea in dogs and encephalitis in foxes. Epizootics have also been caused in bears, wolves, coyotes, and skunks. The official species name is Canine adenovirus and it contains two serotypes.Measles Vaccine: A live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had measles or been immunized with live measles vaccine and have no serum antibodies against measles. Children are usually immunized with measles-mumps-rubella combination vaccine. (From Dorland, 28th ed)Pertussis Vaccine: A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Rabies Vaccines: Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.Haemophilus Vaccines: Vaccines or candidate vaccines containing antigenic polysaccharides from Haemophilus influenzae and designed to prevent infection. The vaccine can contain the polysaccharides alone or more frequently polysaccharides conjugated to carrier molecules. It is also seen as a combined vaccine with diphtheria-tetanus-pertussis vaccine.BCG Vaccine: An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.Poliovirus Vaccine, Inactivated: A suspension of formalin-inactivated poliovirus grown in monkey kidney cell tissue culture and used to prevent POLIOMYELITIS.Rotavirus Vaccines: Vaccines or candidate vaccines used to prevent infection with ROTAVIRUS.Cholera Vaccines: Vaccines or candidate vaccines used to prevent infection with VIBRIO CHOLERAE. The original cholera vaccine consisted of killed bacteria, but other kinds of vaccines now exist.Adenovirus E2 Proteins: Proteins transcribed from the E2 region of ADENOVIRUSES. Several of these are required for viral DNA replication.Typhoid-Paratyphoid Vaccines: Vaccines used to prevent TYPHOID FEVER and/or PARATYPHOID FEVER which are caused by various species of SALMONELLA. Attenuated, subunit, and inactivated forms of the vaccines exist.Smallpox Vaccine: A live VACCINIA VIRUS vaccine of calf lymph or chick embryo origin, used for immunization against smallpox. It is now recommended only for laboratory workers exposed to smallpox virus. Certain countries continue to vaccinate those in the military service. Complications that result from smallpox vaccination include vaccinia, secondary bacterial infections, and encephalomyelitis. (Dorland, 28th ed)Tuberculosis Vaccines: Vaccines or candidate vaccines used to prevent or treat TUBERCULOSIS.Mastadenovirus: A genus of ADENOVIRIDAE that infects MAMMALS including humans and causes a wide range of diseases. The type species is Human adenovirus C (see ADENOVIRUSES, HUMAN).Immunization, Secondary: Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.Chickenpox Vaccine: A live, attenuated varicella virus vaccine used for immunization against chickenpox. It is recommended for children between the ages of 12 months and 13 years.Diphtheria-Tetanus-Pertussis Vaccine: A vaccine consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and whole-cell PERTUSSIS VACCINE. The vaccine protects against diphtheria, tetanus, and whooping cough.Mumps Vaccine: Vaccines used to prevent infection by MUMPS VIRUS. Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. Children are usually immunized with measles-mumps-rubella combination vaccine.Immunization Schedule: Schedule giving optimum times usually for primary and/or secondary immunization.DNA, Viral: Deoxyribonucleic acid that makes up the genetic material of viruses.Adjuvants, Immunologic: Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.Hepatitis A Vaccines: Vaccines or candidate vaccines used to prevent infection with hepatitis A virus (HEPATOVIRUS).Genetic Therapy: Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.Adenoviruses, Porcine: Species of the genus MASTADENOVIRUS, causing neurological disease in pigs.Capsid Proteins: Proteins that form the CAPSID of VIRUSES.Mice, Inbred BALB CMeasles-Mumps-Rubella Vaccine: A combined vaccine used to prevent MEASLES; MUMPS; and RUBELLA.Aviadenovirus: A genus of ADENOVIRIDAE that infects birds. The type species is FOWL ADENOVIRUS A.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Anthrax Vaccines: Vaccines or candidate vaccines used to prevent ANTHRAX.Streptococcal Vaccines: Vaccines or candidate vaccines used to prevent STREPTOCOCCAL INFECTIONS.Gene Transfer Techniques: The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Fowl adenovirus A: The type species of the genus AVIADENOVIRUS, family ADENOVIRIDAE, an oncogenic virus of birds. This is also called CELO virus for chick embryo lethal orphan virus.Dengue Vaccines: Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.Vaccines, Virosome: Vaccines using VIROSOMES as the antigen delivery system that stimulates the desired immune response.Virus Replication: The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.Viral Hepatitis Vaccines: Any vaccine raised against any virus or viral derivative that causes hepatitis.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Poliovirus Vaccine, Oral: A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)Ebola Vaccines: Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Yellow Fever Vaccine: Vaccine used to prevent YELLOW FEVER. It consists of a live attenuated 17D strain of the YELLOW FEVER VIRUS.Plague Vaccine: A suspension of killed Yersinia pestis used for immunizing people in enzootic plague areas.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.SAIDS Vaccines: Vaccines or candidate vaccines designed to prevent SAIDS; (SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME); and containing inactivated SIMIAN IMMUNODEFICIENCY VIRUS or type D retroviruses or some of their component antigens.Fungal Vaccines: Suspensions of attenuated or killed fungi administered for the prevention or treatment of infectious fungal disease.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Viral Proteins: Proteins found in any species of virus.Neutralization Tests: The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).Rubella Vaccine: A live attenuated virus vaccine of duck embryo or human diploid cell tissue culture origin, used for routine immunization of children and for immunization of nonpregnant adolescent and adult females of childbearing age who are unimmunized and do not have serum antibodies to rubella. Children are usually immunized with measles-mumps-rubella combination vaccine. (Dorland, 28th ed)Vaccines, Acellular: Vaccines that are produced by using only the antigenic part of the disease causing organism. They often require a "booster" every few years to maintain their effectiveness.Injections, Intramuscular: Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.Receptors, Virus: Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.Influenza, Human: An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.Salmonella Vaccines: Vaccines or candidate vaccines used to prevent infection with SALMONELLA. This includes vaccines used to prevent TYPHOID FEVER or PARATYPHOID FEVER; (TYPHOID-PARATYPHOID VACCINES), and vaccines used to prevent nontyphoid salmonellosis.Vaccines, Virus-Like Particle: Vaccines using supra-molecular structures composed of multiple copies of recombinantly expressed viral structural proteins. They are often antigentically indistinguishable from the virus from which they were derived.Oncolytic Virotherapy: Use of attenuated VIRUSES as ANTINEOPLASTIC AGENTS to selectively kill CANCER cells.Oncolytic Viruses: Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.Administration, Intranasal: Delivery of medications through the nasal mucosa.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Oncogene Proteins, Viral: Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.Genes, Viral: The functional hereditary units of VIRUSES.Transduction, Genetic: The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.Keratoconjunctivitis: Simultaneous inflammation of the cornea and conjunctiva.Staphylococcal VaccinesAntibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Diphtheria-Tetanus-acellular Pertussis Vaccines: Combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Hemagglutination Inhibition Tests: Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.Cytomegalovirus Vaccines: Vaccines or candidate vaccines used to prevent infection with CYTOMEGALOVIRUS.Immunization Programs: Organized services to administer immunization procedures in the prevention of various diseases. The programs are made available over a wide range of sites: schools, hospitals, public health agencies, voluntary health agencies, etc. They are administered to an equally wide range of population groups or on various administrative levels: community, municipal, state, national, international.Immunity, Humoral: Antibody-mediated immune response. Humoral immunity is brought about by ANTIBODY FORMATION, resulting from TH2 CELLS activating B-LYMPHOCYTES, followed by COMPLEMENT ACTIVATION.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Diphtheria-Tetanus Vaccine: A combined vaccine used to prevent infection with diphtheria and tetanus toxoid. This is used in place of DTP vaccine (DIPHTHERIA-TETANUS-PERTUSSIS VACCINE) when PERTUSSIS VACCINE is contraindicated.Poliovirus Vaccines: Vaccines used to prevent POLIOMYELITIS. They include inactivated (POLIOVIRUS VACCINE, INACTIVATED) and oral vaccines (POLIOVIRUS VACCINE, ORAL).Mice, Inbred C57BLAntigens, Viral: Substances elaborated by viruses that have antigenic activity.Escherichia coli Vaccines: Vaccines or candidate vaccines used to prevent or treat both enterotoxigenic and enteropathogenic Escherichia coli infections.West Nile Virus Vaccines: Vaccines or candidate vaccines used to prevent infection with WEST NILE VIRUS.Shigella Vaccines: Vaccines or candidate vaccines used to prevent bacillary dysentery (DYSENTERY, BACILLARY) caused by species of SHIGELLA.CD8-Positive T-Lymphocytes: A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.Serotyping: Process of determining and distinguishing species of bacteria or viruses based on antigens they share.Capsid: The outer protein protective shell of a virus, which protects the viral nucleic acid.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Conjunctivitis, Viral: Inflammation, often mild, of the conjunctiva caused by a variety of viral agents. Conjunctival involvement may be part of a systemic infection.Herpes Zoster Vaccine: An attenuated vaccine used to prevent and/or treat HERPES ZOSTER, a disease caused by HUMAN HERPESVIRUS 3.Polysorbates: Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.Injections, Intradermal: The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.Brucella Vaccine: A bacterial vaccine for the prevention of brucellosis in man and animal. Brucella abortus vaccine is used for the immunization of cattle, sheep, and goats.Immunity, Cellular: Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.Tetanus ToxoidInfluenza A Virus, H1N1 Subtype: A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Herpesvirus Vaccines: Vaccines or candidate vaccines used to prevent infection by any virus from the family HERPESVIRIDAE.Leishmaniasis Vaccines: Vaccines or candidate vaccines used to prevent infection with LEISHMANIA.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Aluminum Hydroxide: A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Transgenes: Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.Alum Compounds: Aluminum metal sulfate compounds used medically as astringents and for many industrial purposes. They are used in veterinary medicine for the treatment of ulcerative stomatitis, leukorrhea, conjunctivitis, pharyngitis, metritis, and minor wounds.Herpes Simplex Virus Vaccines: Vaccines or candidate vaccines used to prevent infection with viruses from the genus SIMPLEXVIRUS. This includes vaccines for HSV-1 and HSV-2.Diphtheria Toxoid: The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.SqualeneCross Protection: Protection conferred on a host by inoculation with one strain or component of a microorganism that prevents infection when later challenged with a similar strain. Most commonly the microorganism is a virus.Respiratory Syncytial Virus Vaccines: Vaccines or candidate vaccines used to prevent infection with RESPIRATORY SYNCYTIAL VIRUSES.Interferon-gamma: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.Defective Viruses: Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.T-Lymphocytes, Cytotoxic: Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.Cytopathogenic Effect, Viral: Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Cell Transformation, Viral: An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Japanese Encephalitis Vaccines: Vaccines or candidate vaccines used to prevent infection with Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE).Mass Vaccination: Administration of a vaccine to large populations in order to elicit IMMUNITY.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Vaccines, Contraceptive: Vaccines or candidate vaccines used to prevent conception.Macaca mulatta: A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Rotavirus Infections: Infection with any of the rotaviruses. Specific infections include human infantile diarrhea, neonatal calf diarrhea, and epidemic diarrhea of infant mice.Genome, Viral: The complete genetic complement contained in a DNA or RNA molecule in a virus.Virus Cultivation: Process of growing viruses in live animals, plants, or cultured cells.Vaccines, Edible: Vaccines or candidate vaccines derived from edible plants. Transgenic plants (PLANTS, TRANSGENIC) are used as recombinant protein production systems and the edible plant tissue functions as an oral vaccine.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Immunotherapy, Active: Active immunization where vaccine is administered for therapeutic or preventive purposes. This can include administration of immunopotentiating agents such as BCG vaccine and Corynebacterium parvum as well as biological response modifiers such as interferons, interleukins, and colony-stimulating factors in order to directly stimulate the immune system.Gastroenteritis: INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Helper Viruses: Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. Helper and satellite may be of the same or different genus.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Vaccinia virus: The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Immunity, Mucosal: Nonsusceptibility to the pathogenic effects of foreign microorganisms or antigenic substances as a result of antibody secretions of the mucous membranes. Mucosal epithelia in the gastrointestinal, respiratory, and reproductive tracts produce a form of IgA (IMMUNOGLOBULIN A, SECRETORY) that serves to protect these ports of entry into the body.CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Disease Outbreaks: Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.Pseudorabies Vaccines: Vaccines or candidate vaccines used to prevent PSEUDORABIES (Aujeszky's disease), a herpesvirus of swine and other animals.Antigens, Protozoan: Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.beta-Galactosidase: A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-galactosides. Deficiency of beta-Galactosidase A1 may cause GANGLIOSIDOSIS, GM1.Gene Expression Regulation, Viral: Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Whooping Cough: A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Dendritic Cells: Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).Haplorhini: A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).Dose-Response Relationship, Immunologic: A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.Enterovirus: A genus of the family PICORNAVIRIDAE whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated "human enterovirus".Vaccine Potency: The relationship between an elicited ADAPTIVE IMMUNE RESPONSE and the dose of the vaccine administered.Cell Line, Tumor: A cell line derived from cultured tumor cells.Influenza A Virus, H5N1 Subtype: A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 1. The H5N1 subtype, frequently referred to as the bird flu virus, is endemic in wild birds and very contagious among both domestic (POULTRY) and wild birds. It does not usually infect humans, but some cases have been reported.Measles: A highly contagious infectious disease caused by MORBILLIVIRUS, common among children but also seen in the nonimmune of any age, in which the virus enters the respiratory tract via droplet nuclei and multiplies in the epithelial cells, spreading throughout the MONONUCLEAR PHAGOCYTE SYSTEM.Epitopes, T-Lymphocyte: Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.Influenza B virus: Species of the genus INFLUENZAVIRUS B that cause HUMAN INFLUENZA and other diseases primarily in humans. Antigenic variation is less extensive than in type A viruses (INFLUENZA A VIRUS) and consequently there is no basis for distinct subtypes or variants. Epidemics are less likely than with INFLUENZA A VIRUS and there have been no pandemics. Previously only found in humans, Influenza B virus has been isolated from seals which may constitute the animal reservoir from which humans are exposed.Cercopithecus aethiops: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.Rickettsial Vaccines: Vaccines for the prevention of diseases caused by various species of Rickettsia.Smallpox: An acute, highly contagious, often fatal infectious disease caused by an orthopoxvirus characterized by a biphasic febrile course and distinctive progressive skin eruptions. Vaccination has succeeded in eradicating smallpox worldwide. (Dorland, 28th ed)RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Parainfluenza Vaccines: Vaccines or candidate vaccines used to prevent infection with parainfluenza viruses in humans and animals.Respiratory Tract Infections: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.

A novel chimpanzee adenovirus vector with low human seroprevalence: improved systems for vector derivation and comparative immunogenicity. (1/6)

 (+info)

Circumventing antivector immunity by using adenovirus-infected blood cells for repeated application of adenovirus-vectored vaccines: proof of concept in rhesus macaques. (2/6)

Adenovirus has been extensively exploited as a vector platform for delivering vaccines. However, preexisting antiadenovirus immunity is the major stumbling block for application of adenovirus-vectored vaccines. In this study, we found that freshly isolated peripheral blood mononuclear cells (PBMCs), mostly CD14(+) cells, from adenovirus serotype 5 (Ad5)-seropositive primates (humans and rhesus macaques) can be efficiently infected with Ad5 in vitro. On the basis of this observation, a novel strategy based on adenoviral vector-infected PBMC (AVIP) immunization was explored to circumvent antivector immunity. Autologous infusion of Ad5-SIVgag-infected PBMCs elicited a strong Gag-specific cellular immune response but induced weaker Ad5-neutralizing antibody (NAb) in Ad5-seronegative macaques than in macaques intramuscularly injected with Ad5-SIVgag. Moreover, Ad5-seropositive macaques receiving multiple AVIP immunizations with Ad5-SIVenv, Ad5-SIVgag, and Ad5-SIVpol vaccines elicited escalated Env-, Gag-, and Pol-specific immune responses after each immunization that were significantly greater than those in macaques intramuscularly injected with these Ad5-SIV vaccines. After challenged intravenously with a highly pathogenic SIVmac239 virus, macaques receiving AVIP immunization demonstrated a significant reduction in viral load at both the peak time and set-point period compared with macaques without Ad5-SIV vaccines. Our study warranted further research and development of the AVIP immunization as a platform for repeated applications of adenovirus-vectored vaccines.  (+info)

Modification of one epitope-flanking amino acid allows for the induction of friend retrovirus-specific CD8+ T cells by Adenovirus-based immunization. (3/6)

 (+info)

Targeting the genital tract mucosa with a lipopeptide/recombinant adenovirus prime/boost vaccine induces potent and long-lasting CD8+ T cell immunity against herpes: importance of MyD88. (4/6)

 (+info)

Incidence of acute respiratory illnesses among enlisted service members during their first year of military service: did the 2011 resumption of adenovirus vaccination of basic trainees have an effect? (5/6)

This study analyzed the incidence of acute respiratory illnesses (i.e., upper respiratory illnesses, bronchitis and bronchiolitis, and pneumonias) during the first 12 months of service among enlisted members of the active components of the U.S. Armed Forces. Subjects were assigned to cohorts designated 1999 through 2012 corresponding to the years during which they entered service. The objective was to determine if the late 2011 resumption of administration of adenovirus vaccines to basic trainees was associated with a reduction in acute respiratory illnesses among the 2012 cohort. Because acute respiratory illness rates were considerably higher during the first three months than the rest of the first year of service, rates during the first three months and the next nine months of service were compared separately among the cohorts. In the 2012 compared to the prior year cohorts, incidence rates of hospitalizations for pneumonia and of outpatient diagnoses of the other two acute respiratory illness types of interest were lower during the first three months but not the next nine months of enlisted service. The findings suggest a protective effect of adenovirus vaccines during recruit training. Reasons for cautious interpretation of the results are discussed.  (+info)

A single intraduodenal administration of human adenovirus 40 vaccine effectively prevents anaphylactic shock. (6/6)

 (+info)

Substantial protection can be provided against the pre-erythrocytic stages of malaria by vaccination first with an adenoviral and then with an modified vaccinia virus Ankara (MVA) poxviral vector encoding the same ME.TRAP transgene. We investigated whether the two vaccine compon ents adenovirus (Ad) and MVA could be coinjected as a mixture to enhance protection against malaria. A single-shot mixture at specific ratios of Ad and MVA (AdMVA) enhanced CD8 ++ T cell-dependant protection of mice against challenge with Plasmodium berghei. Moreover, the degree of protection could be enhanced after homologous boosting with the same AdMVA mixture to levels comparable with classic heterologous Ad prime-MVA boost regimes. The mixture increased transgene-specific responses while decreasing the CD8 ++ T cell antivector immunity compared to each vector used alone, particularly against the MVA backbone. Mixed vector immunization led to increased early circulating interferon-γ (IFN-γ) response levels and altered
In order to halt the HIV pandemic an effective vaccine must be developed. In this study, investigators will examine the safety and immune response to a prime-boost strategy using two different vaccine regimens, NYVAC-B and rAd5.. Eighty participants will be recruited to this study. Participants will be randomly assigned to one of four different groups (study arms). Each group will receive both study vaccines and placebo but at different times. All NYVAC-B vaccine doses will be the same, but the doses of the rAD5 vaccine will differ from group to group. Some participants in each group will receive only placebo. Participants will visit the study clinic about 13 times over the course of 12 months and be contacted for follow-up for 4 years.. All study injections will be given in the same upper arm area. There will be a total of four injections during the course of the study. After each injection, participants will need to stay in the clinic for at least 25 minutes to check for any adverse reactions. ...
In order to halt the HIV pandemic an effective vaccine must be developed. In this study, investigators will examine the safety and immune response to a prime-boost strategy using two different vaccine regimens, NYVAC-B and rAd5.. Eighty participants will be recruited to this study. Participants will be randomly assigned to one of four different groups (study arms). Each group will receive both study vaccines and placebo but at different times. All NYVAC-B vaccine doses will be the same, but the doses of the rAD5 vaccine will differ from group to group. Some participants in each group will receive only placebo. Participants will visit the study clinic about 13 times over the course of 12 months and be contacted for follow-up for 4 years.. All study injections will be given in the same upper arm area. There will be a total of four injections during the course of the study. After each injection, participants will need to stay in the clinic for at least 25 minutes to check for any adverse reactions. ...
In the context of clinicalgene transfer using viral vectors, the risk of memory antivector immunity is often poorly appreciated. The immunological past of the patient, the site of injection, and the...
Ten researchers from the CDCs NCIRD released a paper arguing that because the immune-boosting effects of breastmilk, nursing mothers should delay breastfeeding their infants.
Ten researchers from the CDCs NCIRD released a paper arguing that because the immune-boosting effects of breastmilk, nursing mothers should delay breastfeeding their infants.
Simian virus 40 (SV40) was an accidental contaminant of vaccines produced in monkey kidney tissue cultures in the 1950s and early 1960s, including a parenteral adenovirus vaccine given to several hundred thousand US military recruits. Detection of SV40 DNA in tumor tissues by some laboratories suggests that SV40 contributes to human cancers. To determine if entry into US Army service during periods of administration of SV40-contaminated adenovirus vaccine was associated with an increased risk of cancer, the authors conducted a case-control study of cancer occurring in male Army veterans who entered service in 1959-1961. Cases of brain tumors (n = 181), mesothelioma (n = 10), and non-Hodgkins lymphoma (n = 220) were identified through a Veterans Administration hospital discharge database, as were colon cancer and lung cancer controls (n = 221). Exposure to adenovirus vaccine was assigned on the basis of known periods of adenovirus vaccine administration and dates of Army entry obtained for ...
Rogers et al., 2001: Rogers WO, Baird JK, Kumar A, Tine JA, Weiss W, Aguiar JC, Gowda K, Gwadz R, Kumar S, Gold M, Hoffman SL. Multistage multiantigen heterologous prime boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques. Infection and immunity. 2001; 69(9); 5565-5572. [PubMed: 11500430 ...
7. Heres the scary part: Each tablet contains albumin, a derivative of human blood. And, a theoretical risk for transmission of Creutzfeld-Jakob disease, which is a fatal brain disease commonly referred to as "human mad-cow disease." However, the vaccine package insert notes that no cases of CJD have been identified from human albumin. Clearly, we need to be concerned about those vaccines that contain human or bovine (cow) albumin, or are made with blood products derived from cattle (like fetal calf serum). To the extent that this information is available, these components are listed in Catherines new book, Vaccination Voodoo, What YOU Dont Know About Vaccines. Furthermore, could there be a possibility of homologous recombination? "Homologous recombination is conserved across all three domains of life as well as viruses, suggesting that it is a nearly universal biological mechanism." [5 ...
Human sera from the United States, Thailand, and sub-Saharan Africa and chimpanzee sera were tested for neutralizing antibodies to 3 chimpanzee adenoviruses. Antibodies were more common in humans residing in sub-Saharan Africa than in humans living in the United States or Thailand. This finding suggests cross-species transmission of chimpanzee adenoviruses ...
Effects of ,I,Saiko-ka-ryukotsu-borei-to,/I, (SRBT) on theophylline-induced tachycardia in anesthetized rats and theophylline-induced locomotion and convulsions in mice were examined. An intraduodenal administration of SRBT (1 g/kg) prevented theophylline (5 mg/kg, i.v.)-induced tachycardia in rats. SRBT also attenuated an increase in arterial blood pressure with a slow reduction in heart rate of rats treated with theophylline, with no influence on the plasma level of theophylline. However, SRBT did not change the beating rate of right atrium isolated from rats in the absence or presence of theophylline or isoproterenol. The locomotor activity of theophylline in mice was reduced by the treatment with SRBT. Furthermore, the latency of convulsions in mice induced by administration of theophylline at a higher dose (240 mg/kg, i.p.) was prolonged by treatment with SRBT (1 g/kg, p.o.) and seven out of fifteen mice were saved from death due to convulsions. These results suggest that ...
0139] [0140]Aboubakar, M., 1999. Physico-chemical characterization of insulin-loaded poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization. International Journal of Pharmaceutics 183, 63-66. [0141]Aftabrouchard, D. & E. Doelker, 1992. Preparation methods for biodegradable microparticles loaded with water- soluble drugs. S. T. P. Pharma Sciences 2, 365-380. [0142]Aiedeh, K., E. Gianasi, I. Orienti & V. Zecchi, 1997. Chitosan microcapsules as controlled release systems for insulin. Journal of Microencapsulation 14, 567-576. [0143]Al Achi, A. & R. Greenwood, 1993a. Human insulin binding to erythrocyte-membrane. Drug Development of Industrial Pharmacy 19, 673-684. [0144]Al Achi, A. & R. Greenwood, 1993b. Intraduodenal administration of biocarrier-insulin systems. Drug Development Industrial of Pharmacy 19, 1303-1315. [0145]Al Achi, A. & R. Greenwood, 1994. Human insulin absorption from the intestine in diabetic rats. Drug Development of Industrial Pharmacy 20, 2333-2339. ...
In fact, Ive been so excited, Ive planned so that I can cross off things. The witch can reduce irritation, itching and speed healing time. Enamel fillers, inserted into the depleted areas of her teeth, and costing £50, were her only option. But if it is not treated, it can advance to periodontitis (pair-ee-oh-don-TEYE-tuhss). . Dysfunction Type 2 Diabetes Warning Signs. But major apthous ulcers, defined as larger than 10 mm in size, can take more than a month to heal and can cause scarring when they finally do heal.. Each guided climb Dating directly with ivillage for 3 12 hours and wants to Provide insight! And you might have trouble swallowing or difficulty speaking without the lubrication that saliva provides. Gum recession causes the formation of gaps or pockets between the teeth and they become the perfect surrounding for bacteria. If you pop it could spread the virus so best to leave to heal. Do you think your cat may have been bitten by an insect, had a reaction…now it is scabbed ...
To elucidate the first pass metabolism of the dopamine prodrug N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) in the small intestine and liver of dogs, the blood and plasma concentrations of unchanged TA-870 and metabolites in the gastroduodenal vein, portal vein, hepatic vein, and abdominal aorta were measured by HPLC after intraduodenal administration of TA-870. In addition, an in vitro metabolic study of TA-870 was carried out using liver, small intestinal wall, and blood homogenates of dogs. The order of maximal concentration (Cmax 0-30 min) in gastroduodenal blood or plasma was unchanged TA-870 greater than deethoxycarbonylated TA-870 (DEC-TA-870) greater than conjugated dopamine greater than free dopamine (DA) greater than free homovanillic acid (HVA) greater than free 3,4-dihydroxyphenylacetic acid (DOPAC). This result showed that the main pathway of metabolism in the small intestine is catechol ester hydrolysis and minor pathways are amido hydrolysis, oxidative ...
Rhedin S, Lindstrand A, Rotzén-Östlund M, et al. Clinical utility of PCR for common viruses in acute respiratory illness. Pediatrics. 2014 Mar;133(3):e538-45. Full-text for Childrens and Emory users. BACKGROUND: Acute respiratory illness (ARI) accounts for a large proportion of all visits to pediatric health facilities. Quantitative real-time polymerase chain reaction (qPCR) analyses allow sensitive detection of viral nucleic…
Background: Nearly 3 million people worldwide are coinfected with HIV and HCV. Affordable strategies for prevention are needed. We developed a novel vaccination regimen involving replication-defective and serologically distinct chimpanzee adenovirus (ChAd3, ChAd63) vector priming followed by modified vaccinia Ankara (MVA) boosts, for simultaneous delivery of HCV non-structural (NSmut) and HIV-1 conserved (HIVconsv) region immunogens. Methods: We conducted a phase I trial in which 33 healthy volunteers were sequentially enrolled and vaccinated via the intramuscular route as follows: 9 received ChAd3-NSmut [2.5 × 1010 vp] and MVA-NSmut [2 × 108 pfu] at weeks 0 and 8, respectively; 8 received ChAdV63.HIVconsv [5 × 1010 vp] and MVA.HIVconsv [2 × 108 pfu] at the same interval; 16 were co-primed with ChAd3-NSmut [2.5 × 1010 vp] and ChAdV63.HIVconsv [5 × 1010 vp] followed at week 8 by MVA-NSmut and MVA.HIVconsv [both 1 × 108 pfu]. Immunogenicity was assessed using peptide pools in ex vivo ELISpot and
I clicked & clicked my Combat Boots together & said "Theres no place like home, theres no place like home",, Pooooooooooooooffffffffffffff .....17 days later .... here I am "Home"..... I was so happy to arrive last night, late, but HOME!. I slept in my bed, with my sheets, snuggled up to The Better Half on my left & our fuzzy 4 legged creature on my right, I am home!. I am an ANCOC Graduate!!. Thank You, Thank You.... To those of you who are Military,, you understand, To you all civilians, Its like receiving a degree, after years and years of studying. . . . Its like crossing a finish line!!. I took pictures of my cell ~ I mean Barracks ~ they were accidentally deleted...I had a basic trainee tell me a few weeks ago "Being in Basic Training ..was like being in prison", I asked her .."Have you been in prison?".. "NO" She said: Then how would she know..?!!?!!?!!. That got me to thinking, One of my classmates is a prison guard, I came into class one day and asked him,, "Do prisoners have more ...
Tweets about Acute Respiratory Illness - NowTrending.HHS.gov is tracking disease trends and terms on twitter 140 characters at a time. The Now Trending 2012 HHS/ASPR app competition winner.
Tweets about Acute Respiratory Illness - NowTrending.HHS.gov is tracking disease trends and terms on twitter 140 characters at a time. The Now Trending 2012 HHS/ASPR app competition winner.
Searle, C E. and Jones, E L., "Effects of repeated applications of two semi-permanent hair dyes to the skin of a and dbaf mice." (1977). Subject Strain Bibliography 1977. 151 ...
Acute respiratory illness is the leading cause of asthma exacerbations yet the mechanisms underlying this association remain unclear. To address the deficiencies in our understanding of the molecular events characterizing acute respiratory illness-induced asthma exacerbations, we undertook a transcriptional profiling study of the nasal mucosa over the course of acute respiratory illness amongst individuals with a history of asthma, allergic rhinitis and no underlying respiratory disease. Transcriptional profiling experiments were performed using the Agilent Whole Human Genome 4X44K array platform. Time point-based microarray and principal component analyses were conducted to identify and distinguish acute respiratory illness-associated transcriptional profiles over the course of our study. Gene enrichment analysis was conducted to identify biological processes over-represented within each acute respiratory illness-associated profile, and gene expression was subsequently confirmed by quantitative
We investigated a possible role of endogenous secretin and cholecystokinin (CCK) in inhibition of gastric acid secretion induced by intraduodenal administration of oleic acid in rats. Intraduodenal ad
Read "A cluster of coxsackievirus A21 associated acute respiratory illness: the evidence of efficient transmission of CVA21, Archives of Virology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
An acute respiratory infection is an infection that affects your normal breathing pattern. It normally starts as a viral infection inside the nose, the trachea (windpipe) or even the lungs. If the infection is not treated effectively, it can spread to the entire respiratory system.
See also: Adenovirus vaccine. Safe and effective adenovirus vaccines were developed for adenovirus serotypes 4 and 7, but were ... 2000). "Adult adenovirus infections: loss of orphaned vaccines precipitates military respiratory disease epidemics". Clin ... Enteric adenoviruses 40 and 41 cause gastroenteritis, usually in children. For some adenovirus serotypes, the clinical spectrum ... Some adenoviruses (e.g., serotypes 1, 2, 5, and 6) have been shown to be endemic in parts of the world where they have been ...
Adenoviruses are being actively developed as vaccines. Retroviruses are one of the mainstays of current gene therapy approaches ... If the vaccine or gene therapy fails in clinical trials, the virus can't be used again in the patient for a different vaccine ... A viral vaccine induces expression of pathogen proteins within host cells similarly to the Sabin Polio vaccine and other ... "Impact of Preexisting Adenovirus Vector Immunity on Immunogenicity and Protection Conferred with an Adenovirus-Based H5N1 ...
Main article: Adenovirus vaccine. In the past, US military recruits were vaccinated against two serotypes of adenovirus, with a ... Currently, there is no adenovirus vaccine available to the general public, but a vaccine is available for the United States ... matrix protein M1 on the platform of the adenovirus dodecahedron". Vaccine. 27 (52): 7385-93. doi:10.1016/j.vaccine.2009.09.021 ... Canine adenovirus 2 (CAdV-2) is one of the potential causes of kennel cough. Core vaccines for dogs include attenuated live ...
Most combination vaccines for dogs contain a modified canine adenovirus type-2. CAV-2 is one of the causes of respiratory ... CAV-2 vaccine is much less likely to cause side effects than CAV-1 vaccine. One study has shown the vaccine to have a duration ... Infectious canine hepatitis is an acute liver infection in dogs caused by canine adenovirus type-1 (CAV-1). CAV-1 also causes ... Prevention is through vaccination (ATCvet code QI07AA05 (WHO) and various combination vaccines). ...
"Dna encoding ovine adenovirus (oav287) and its use as a viral vector". Google Patents. 2017-12-12. Retrieved 2017-12-12. " ... Later, he concentrated on the development of DNA vaccines and the details of the work has since been published as an article, ... Known for his studies in the fields of RNA virus replication and vaccine development, Vrati is an elected fellow of the ... List of vaccine topics Immunotherapy India portal Medicine portal Please see Selected bibliography section "Awardees of ...
"Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges". Virology. 353 (2): ... There are currently no Food and Drug Administration-approved vaccines for the prevention of MVD. Many candidate vaccines have ... "Marburg virus vaccines: Comparing classical and new approaches". Vaccine. 20 (3-4): 586-593. doi:10.1016/S0264-410X(01)00353-X ... "Clinical and Vaccine Immunology. 13 (4): 444-451. doi:10.1128/CVI.13.4.444-451.2006. PMC 1459631 . PMID 16603611.. ...
... cells are used to produce several vaccines including Adenovirus, MMR and Varicella zoster. Infected WI-38 cells secrete ... Over a billion vaccine doses worldwide can be traced to work done on WI-38, covering conditions including measles and rubella. ... Fetal tissue in vaccines "WI-38 (ATCC® CCL-75™)". Hayflick, Leonard (March 1965). "The Limited in vitro Lifetime of Human ... Researchers in labs across the globe have since used WI-38 in their discoveries, most notably in the development of vaccines. ...
Reoviruses vaccines are advocated (in dams or in broilers) do not entirely solve the problem. General hygiene and correct ... Causing agents may include viruses : reovirus (often considered as unique cause), adenoviruses, enteroviruses, rotaviruses, ...
"Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing ... "Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs". Mol ... Schabacker, DS; Kirschbaum, KS; Segre, M (2000). "Exploring the feasibility of an anti-idiotypic cocaine vaccine: analysis of ...
"Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges". Virology. 353 (2): ... There are currently no Food and Drug Administration-approved vaccines for the prevention of MVD. Many candidate vaccines have ... "Marburg virus vaccines: Comparing classical and new approaches". Vaccine. 20 (3-4): 586-593. doi:10.1016/S0264-410X(01)00353-X ... Vaccine. 22 (25-26): 3495-3502. doi:10.1016/j.vaccine.2004.01.063. PMID 15308377. Hevey, M.; Negley, D.; Vanderzanden, L.; ...
Vaccine[edit]. There are several H5N1 vaccines for several of the avian H5N1 varieties, but the continual mutation of H5N1 ... "Protection of Mice and Poultry from Lethal H5N1 Avian Influenza Virus through Adenovirus-Based Immunization". J. Virol. 80 (4 ... "There is no H5N1 pandemic so there can be no pandemic vaccine".[43] However, "pre-pandemic vaccines" have been created; are ... Vaccine manufacturing companies are being encouraged to increase capacity so that if a pandemic vaccine is needed, facilities ...
Notably, participants immune to the common cold virus adenovirus type 5 had a higher risk of HIV infection. The vaccine was ... During a randomized, double-blind clinical trial testing the efficacy of the prototype HIV vaccine called V520 there appeared ... had been stopped suspecting the higher rate of HIV infection among individuals in the vaccinated was because the vaccine ...
The causal agent is Duck adenovirus 1, an adenovirus in the genus Atadenovirus. Flock hygiene and minimization of inter-species ... Inactivated vaccines may control the disease, but will not cure it. "Overview of Egg Drop Syndrome in Poultry". Retrieved 26 ...
It is an oncolytic A11/Ad3 Chimeric Group B Adenovirus, previously described as oncolytic vaccine ColoAd1. It is intended to be ... Oncolytic adenovirus Oncolytic adenovirus#Directed Evolution PsiOxus Therapeutics Initiates Combination Study of Merck's ... Dec 2015 PsiOxus Therapeutics announces positive study results of oncolytic vaccine enadenotucirev at 2014 ASCO annual meeting ... Ovarian cancer oncolytic vaccine receives positive reviews. an 2015 Enadenotucirev trials Phase I / II Study of Enadenotucirev ...
Several intranasal vaccines have been developed that contain canine adenovirus in addition to B bronchiseptica and canine- ... To increase their effectiveness, vaccines should be administered as soon as possible after a dog enters a high-risk area, such ... Edinboro, C; Ward, M; Glickman, L (February 2004). "A Placebo-controlled Trial of Two Intranasal Vaccines to Prevent ... Prevention is by vaccinating for canine adenovirus, distemper, parainfluenza, and Bordetella. In kennels, the best prevention ...
NIAID HIV Vaccine Trials Network. Safety and Immunogenicity of a Recombinant Adenovirus Serotype 35-Vectored HIV-1 Vaccine in ... and the NIAID HIV Vaccine Trials Network. HIV-DNA priming alters T-cell response to HIV-adenovirus vaccine even when responses ... Trivalent Adenovirus Type 5 HIV Recombinant Vaccine Primes for Modest Cytotoxic Capacity That Is Greatest in Humans with ... In 2007, she co-founded the Vaccine Infectious Disease Institute at Fred Hutch and has served as sole director of the Vaccine ...
Novel ideas in the field include recombinant DNA-based vaccines, such as one made using human adenovirus (a common cold virus) ... The injectable polio vaccine developed by Jonas Salk was one of the first products mass-produced using cell culture techniques ... This vaccine was made possible by the cell culture research of John Franklin Enders, Thomas Huckle Weller, and Frederick ... Vaccines for polio, measles, mumps, rubella, and chickenpox are currently made in cell cultures. Due to the H5N1 pandemic ...
This work was important to the development of a rotavirus vaccine. He also identified two new species of adenoviruses (later ... As more countries use the vaccine, the incidence is decreasing. British Library P. S. Sharma, The Indian Forester, Vol 50, p. ... Following the introduction of the rotavirus vaccine, worldwide the incidence of deaths of children caused by rotavirus has ... Clinical efficacy of the RIT 4237 live attenuated bovine rotavirus vaccine in infants vaccinated before a rotavirus epidemic" J ...
Currently, there is no adenovirus vaccine available to the general public, but a vaccine is available for the United States ... Adenoviruses Stanford University - Adenoviruses Adenoviruses General Concepts General information on Adenovirus DNA virus ... Tupaia adenovirus (TAV) (Tree shrew adenovirus 1) has been isolated from tree shrews. Otarine adenovirus 1 has been isolated ... Matrix protein M1 on the platform of the adenovirus dodecahedron". Vaccine. 27 (52): 7385-7393. doi:10.1016/j.vaccine.2009.09. ...
... but it also raised concerns because the military was using live adenoviruses as vaccines against adenovirus-induced acute ... Doerfler, W. (2012-12-06). The Molecular Biology of Adenoviruses I: 30 Years of Adenovirus Research 1953-1983. Springer Science ... and determining the molecular and kinetic parameters of adenovirus infection. He showed that adenoviruses could be divided into ... HUEBNER (1963). "Specific Adenovirus Complement-Fixing Antigens in Virus-Free Hamster and Rat Tumors". Proceedings from the ...
Second generation vaccines were developed to reduce the risks from live vaccines. These are subunit vaccines, consisting of ... adenovirus tripartite leader (TPL) sequences and modifications to the polyadenylation and transcriptional termination sequences ... First generation vaccines are whole-organism vaccines - either live and weakened, or killed forms. Live, attenuated vaccines, ... A veterinary DNA vaccine to protect horses from West Nile virus has been approved. DNA vaccines elicit the best immune response ...
HIV is a very difficult virus for which to make a vaccine.In some trials, groups given experimental HIV vaccines have actually ... Safety and Immunogenicity of the Merck adenovirus serotype 5 (MRKAd5) and MRKAd6 Human Immunodeficiency Virus Type 1 trigene ... Clinical and Vaccine Immunology. 2009, 16, 1285-1292. Mehta, G.; Islam, K. Total Synthesis of the Novel Angiogenesis Inhibitors ... vaccines alone and in combination in healthy adults. ...
This vaccine is derived from a chimpanzee adenovirus, Chimp Adenovirus type 3 (ChAd3), genetically engineered to express ... cAd3-ZEBOV (also known as the NIAID/GSK Ebola vaccine or cAd3-EBO Z) is an experimental vaccine for two ebolaviruses, Ebola ... First volunteer receives new Ebola vaccine in UK trial First British volunteer injected with trial Ebola vaccine in Oxford, The ... "Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, ...
The hepatitis B vaccine is the first vaccine that has been established to prevent cancer (hepatocellular carcinoma) by ... The adenovirus E1B protein (55K) prevents p53 from regulating genes by binding to the site on p53 which binds to the genome.[32 ... In 2006, the U.S. Food and Drug Administration approved a human papilloma virus vaccine, called Gardasil. The vaccine protects ... The adenovirus early region 1A (E1A) is an oncoprotein which binds to Rb and can stimulate transcription and transform cells.[ ...
... and could be preferentially transformed by adenovirus. Adenoviruses transform neuronal lineage cells much more efficiently than ... "USA FDA CTR For Biologics Evaluation and Research Vaccines and Related Biological Products Advisory Committee Meeting" (PDF). ... The cells were cultured by van der Eb; the transformation by adenovirus was performed by Frank Graham, a post-doc in van der ... However, the original adenovirus transformation was inefficient, suggesting that the cell that finally produced the HEK 293 ...
... adenovirus, severe acute respiratory syndrome (SARS) and measles. Chest radiographs (X-ray photographs) often show a pulmonary ... as the decrease of occult pneumonia after vaccination of children with a pneumococcal vaccine suggests. Infiltration commonly ...
... as anti-tumoral and anti-viral vaccines, tracer of synaptic junctions, oncolytic virus and as a platform to generate chimeric ... This review updates canine adenovirus serotype 2 (CAV-2, also known as CAdV-2) biology and gives an overview of the generation ... Preclinical and clinical studies using human derived adenoviruses (HAd) have demonstrated the feasibility of flexible hybrid ... Adenovirus vectors have significant potential for long- or short-term gene transfer. ...
Tagged canine adenovirus type 2 parainfluenza bordetella bronchiseptica vaccine. Home. canine adenovirus type 2 parainfluenza ... Adenovirus 1 in canines causes respiratory infections, targets a number of organs within the physique, and causes infectious ...
Adenovirus vaccine. Adenovirus vaccine is only available for United States military personnel. There is currently no adenovirus ... Adenovirus vaccine can prevent infection with some types of adenovirus.. Adenoviruses can cause illness that is usually mild, ... Adenovirus vaccine contains live adenovirus Type 4 and Type 7. It will prevent most illness caused by these two virus types. ... Vaccine Information Statement. Adenovirus Vaccine (1/8/20). Department of Health and Human Services. Centers for Disease ...
Proper Name: Adenovirus Type 4 and Type 7 Vaccine, Live, Oral. Trade Name: None. Manufacturer: Barr Labs, Inc.. Indication: ... October 20, 2014 Approval Letter - Adenovirus Type 4 and Type 7 Vaccine, Live, Oral. To revise the package insert to remove ... Package Insert - Adenovirus Type 4 and Type 7 Vaccine, Live, Oral. (PDF - 129KB) ... Approval History, Letters, Reviews and Related Documents - Adenovirus Type 4 and Type 7 Vaccine, Live, Oral (ZIP - 1.5MB) ...
... that recognized a component of the vaccine (adenovirus serotype 5 [Ad5]). ... Moreover, subsequent analyses indicated that the vaccine made some individuals more susceptible to HIV, in particular ... A clinical trial testing a candidate HIV vaccine known as the STEP study was halted in September 2007 after interim analysis ... Tags: Adenovirus, Antibodies, Cancer, Cell, Clinical Trial, HIV, HIV/AIDS, HIV-1, Immune System, Research, Vaccine ...
An adenovirus vaccine is a vaccine against Adenovirus. It was used by the United States military from 1971 to 1999, but was ... "Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune ... Vaccine. 24 (15): 2835-42. PMC 1955759 . PMID 16480793. doi:10.1016/j.vaccine.2005.12.062. "Vaccine Trials For "Boot Camp Crud ... It should not be confused with the strategy of using adenovirus as a carrier to develop vaccines for other pathogens, or as a ...
Adenovirus type 4 and type 7 live vaccine is used to prevent febrile (with fever) acute respiratory disease (ARD) caused by ... This vaccine is to be administered only by or under the supervision of your doctor or other health care professional. ... This vaccine is given to military personnels 17 to 50 years of age. ... adenovirus type 4 and type 7. It works by causing your body to produce its own protection (antibodies) against the virus. ...
Replication defective adenoviruses have emerged as promising vectors for delivery of vaccine antigens. The development of new ... This thesis describes the construction and optimisation of ChAdOX1, a new vector based on chimpanzee adenovirus Y2S, which has ... Aft intramuscular administration, HAdV-S (Human adenovirus C) based vectors elicited superior transgene product specific T cell ... and antibody responses compared to a selection of chimpanzee adenovirus vectors (from Human adenovirus EJ including ChAdOX1. ...
Introduction Oral vaccines delivered as tablets offer a number of advantages over traditional parenteral-based vaccines ... N = 10 for Ad vaccine groups. N = 4 for TIV vaccine. Ad adenovirus, CI confidence interval, ELISA enzyme-linked immunosorbent ... The various vaccine combinations were tested by blending monovalent recombinant adenovirus vaccines, each expressing ... We have been developing an oral-based adenovirus platform for vaccine delivery. The vaccine platform consists of a replication- ...
Upon subcutaneous vaccination with the adenovirus-PSA prostate cancer vaccine, the adenovirus infects cells and expresses PSA. ... replication-deficient type 5 adenovirus carrying the human prostate-specific antigen (PSA), with potential immunostimulating ... A cancer vaccine composed of a genetically engineered, ... adenovirus-PSA prostate cancer vaccine A cancer vaccine ... Upon subcutaneous vaccination with the adenovirus-PSA prostate cancer vaccine, the adenovirus infects cells and expresses PSA. ...
... we aim to present and discuss the progress and prospects in the field of vaccine research towards SARS-CoV-2 using adenovirus ( ... Researchers and clinicians from all over the world are advancing the development of a vaccine against novel human SARS-CoV-2 ... Nevertheless, currently there are no licensed vaccines for the novel coronaviruses. ... Keywords: SARS-CoV-2; vaccine; adjuvant; adenovirus; COVID-19 SARS-CoV-2; vaccine; adjuvant; adenovirus; COVID-19 ...
... teamed up with the University of Oxfords Jenner Institute to develop more cost-effective manufacturing processes for vaccines ... Adenovirus is a popular viral vector for vaccine development. It has been used in vaccine candidates against tuberculosis, HIV ... The partnership aims to improve the production of vaccines that use adenovirus as vectors. With 30 years experience in viral ... Merck KGaA hooks up with Jenner Institute on adenovirus-vector vaccine production ...
Other Name: Adenovirus Serotype 4-vectored H5N1 Influenza Vaccine. Biological: Sanofi Pasteur Influenza Virus Vaccine, H5N1 ... Other Name: Adenovirus Serotype 4-vectored H5N1 Influenza Vaccine. Biological: Sanofi Pasteur Influenza Virus Vaccine, H5N1 ... Other Name: Adenovirus Serotype 4-vectored H5N1 Influenza Vaccine. Biological: Sanofi Pasteur Influenza Virus Vaccine, H5N1 ... Other Name: Adenovirus Serotype 4-vectored H5N1 Influenza Vaccine. Biological: Sanofi Pasteur Influenza Virus Vaccine, H5N1 ...
The development of safe and effective vaccine is urgent need. In this study, we constructed a novel simian adenovirus type 23 ... the immune response and protective efficacy of vaccine were extensively evaluated. The data suggested that Sad23L-prM-E vaccine ... By vaccinating the common marmosets with prime immunization of vaccine, and upon challenge with a high dose of ZIKV to the ... could protect marmosets against a high dose of ZIKV challenge, which provided a promising vaccine for preventing ZIKV infection ...
Received HIV vaccine(s) in a prior HIV vaccine trial. Participants who received a control/placebo in an HIV vaccine trial are ... Participants will be randomly assigned to receive either the rAd26 vaccine or a placebo vaccine. All vaccines will be injected ... Evaluating the Safety and Immune Response of an Adenovirus-Based HIV Vaccine in HIV-Uninfected Adults. The safety and ... Many HIV preventive vaccines that are in development use a recombinant adenovirus serotype 5 (rAd5) vector as a way of ...
Phase II Study of Adenovirus/PSA Vaccine in Men With Recurrent Prostate Cancer After Local Therapy APP21 (APP21). The safety ... Clinical protocol: phase I study of an adenovirus/prostate-specific antigen vaccine in men with metastatic prostate cancer. Hum ... Phase II Study of Adenovirus/PSA Vaccine in Men With Recurrent Prostate Cancer After Local Therapy. ... Biological: Adenovirus/PSA Vaccine 1x10E8pfu in Gelfoam subcutaneously on day 0, 30, 60 ...
Here, we report the development of a new candidate rabies vaccine, designed to enable low-cost single-dose pre-exposure human ... ChAdOx2 RabG is based upon a simian adenovirus-vectored candidate previously shown to achieve protection after a single dose in ... Although it is eminently preventable, with highly efficacious vaccines available for both humans and animals, it still causes ... the second human disease for which an efficacious vaccine was developed, by Pasteur in 1885. ...
The 2011 implementation of a replacement vaccine led to dramatic and sustained decreases in ARD cases, supporting continuation ... The 1999 cessation of vaccination against adenovirus types 4 and 7 among US Army trainees resulted in reemergence of acute ... During the 1999-2010 lapse in adenovirus vaccine coverage, 8 adenovirus-infected service members died (13). Estimates showed ... Kuschner RA, Russell KL, Abuja M, Bauer KM, Faix DJ, Hait H, et al.; Adenovirus Vaccine Efficacy Trial Consortium. A phase 3, ...
Expanded Characterization of Immune Response to Merck Adenovirus 5 Gag/Pol/Nef Vaccine Given to HIV Uninfected Adults. The ... Adenovirus vector-based vaccines for human immunodeficiency virus type 1. Hum Gene Ther. 2005 Feb;16(2):149-56. Review. ... to a three-dose regimen of an adenovirus-based HIV-1 vaccine in HIV-uninfected adults. ... HIV vaccines or placebos in prior HIV trial. Participants who can provide documentation that they received a placebo in a prior ...
Influenza vaccine or any vaccines that are not live attenuated vaccines received within 14 days prior to first vaccination or ... Immune Response to an HIV DNA Plasmid Vaccine Prime Followed by Adenovirus Boost in HIV-uninfected Individuals. This study is ... HIV vaccine(s) received in a prior HIV vaccine trial. For potential participants who have received control/placebo in an HIV ... Experimental vaccine(s) received within the last 5 years in a prior vaccine trial. More information on this criterion can be ...
A Shedding Study of Adenovirus Serotype 26 Based Respiratory Syncytial Virus Pre-fusion F Protein (Ad26.RSV.preF) Vaccine in ... Participants will receive one intramuscular injection of an adenovirus serotype 26- based vaccine encoding for the respiratory ... Janssen Vaccines & Prevention B.V. Clinical Trial. Janssen Vaccines & Prevention B.V.. ... Participant has received any RSV vaccine in any previous RSV vaccine study at any time prior to randomization ...
Results Two volunteers withdrew for vaccine-unrelated reasons. No vaccine-related serious adverse events or reactions occurred ... Here, detail safety and tolerability of these vaccines are reported. Methods Local and systemic reactogenicity data were ... vaccines or placebo to 32 healthy HIV-1/2-uninfected adults in Oxford, UK and elicited high frequencies of HIV-1-specific T ... adenovirus ChAdV-63 and a non-replicating poxvirus, modified vaccinia virus Ankara. A block-randomized, single-blind, placebo- ...
The objective of these studies is to develop a replication-competent, vaccine vector based on the adenovirus serotype 4 (Ad4) ... The vaccine candidates were assessed in vitro following infection of A549 cells for Env-specific protein expression and for ... ConclusionsThe Ad4Env vaccine vectors express high levels of Env glycoprotein and induce both Env-specific humoral and cellular ... Ad4Env vaccines induced humoral immune responses in rabbits that recognized Env 1086 gp140 and V1V2 polypeptide sequences ...
Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein. ... Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein ... Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein ... Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein ...
  • The simian adenovirus, ChAdOx1, and modified vaccinia Ankara virus, MVA, encoding a prostate cancer-associated antigen, the six transmembrane epithelial antigen of the prostate 1 (STEAP1), induced strong sustained antigen-specific CD8+ T-cell responses in C57BL/6 and BALB/c male mice. (medworm.com)
  • Moreover, our data suggest that future T cell-focused vaccine design should aim to induce immunodominant responses to highly conserved regions of the virus. (iavi.org)
  • Many vaccines require an adjuvant to induce a strong immune response. (utexas.edu)
  • Given orally as enteric-coated tablets, the vaccines contain lyophilized Ad4 and Ad7 that induce both humoral and cell-mediated immunity as they replicate asymptomatically in the gut of the vaccinee. (asm.org)
  • In studies comparing these two types of Ads, Ad5[E1−,E2b−] vaccines have been found to promote the decreased expression of viral proteins, persist longer in vivo , and induce less virus-associated toxicity following in vivo administration ( 16 , 28 , 29 ). (asm.org)
  • We aim to develop an effective vaccine able to induce long lasting protection using a simplified immunization schedule. (grantome.com)
  • Surprisingly, the species D vaccines again failed to induce greater levels of protective immunity as compared with the species C Ad5 when delivered intramuscularly. (elsevier.com)
  • A conditionally replicative adenovirus (CRAd) with a 24 base pair deletion in the retinoblastoma-binding domain of the E1A protein (Ad5- Δ24E3), is unable to silence retinoblastoma, and therefore unable to induce S-phase in host cells. (wikipedia.org)
  • DNA vaccines have potential advantages over conventional vaccines, including the ability to induce a wider range of immune response types. (wikipedia.org)
  • Last August, it reached a deal with Baylor College of Medicine to develop vaccines against serious but neglected emerging diseases, with an initial focus on schistosomiasis. (fiercepharma.com)
  • While Janssen is taking the lead, the program is a large collaboration including the Beth Israel Deaconess Medical Center (BIDMC), the Bill & Melinda Gates Foundation, the National Institute of Allergy and Infectious Diseases (NIAID), the HIV Vaccine Trials Network (HVTN), the International AIDS Vaccine Initiative, the US Military HIV Research Program, the Ragon Institute and the Los Alamos National Laboratory. (typepad.com)
  • Their experience informed vaccine development for many infectious diseases ( 4 , 6 , 7 ). (frontiersin.org)
  • State laws require dogs to have current vaccines for specific deadly diseases, such as rabies. (vetinfo.com)
  • Your dog may need additional dog vaccines for localized diseases. (vetinfo.com)
  • Diseases protected by core vaccines kill many animals per year. (vetinfo.com)
  • Print-friendly version of this chart pdf icon [4 pages] can be found in the Epidemiology of Vaccine-Preventable Diseases textbook. (cdc.gov)
  • Today, vaccines help control and prevent a range of serious diseases. (medicalnewstoday.com)
  • His work on rat brains help identify Mov34 protein which has assisted in the development of vaccines for flaviviral diseases like Japanese encephalitis and Dengue. (wikipedia.org)
  • Vaccines have historically been the most effective means to fight and eradicate infectious diseases. (wikipedia.org)
  • Vaccines have contributed to the eradication of smallpox, one of the most contagious and deadly diseases in humans. (wikipedia.org)
  • While killed vaccines do not have this risk, they cannot generate specific killer T cell responses and may not work at all for some diseases. (wikipedia.org)
  • In 1983, Enzo Paoletti and Dennis Panicali at the New York Department of Health devised a strategy to produce recombinant DNA vaccines by using genetic engineering to transform ordinary smallpox vaccine into vaccines that may be able to prevent other diseases. (wikipedia.org)
  • Despite the Vatican's longstanding and complete opposition to abortion, their Pontifical Academy for Life concluded in 2005 that parents should allow their children to receive vaccines made from fetal tissue, to protect them from infectious diseases. (wikipedia.org)
  • Although vaccines exist for the diseases listed below, only smallpox has been eliminated worldwide. (wikipedia.org)
  • Ginsberg showed the process by which the adenovirus caused disease after entering host cells, leading to the creation of vaccines against various infectious diseases and showing how cancers could be triggered by oncoviruses. (wikipedia.org)
  • Dr. Robert M. Chanock, who headed the Laboratory of Infectious Diseases at the NIAID, noted that "he had accomplished all he could with adenoviruses" before moving on to study HIV. (wikipedia.org)
  • The trial is conducted by the HIV Vaccine Trials Network and sponsored by the National Institute of Allergy and Infectious Diseases. (wikipedia.org)
  • Core vaccines protect animals from severe, life-threatening diseases which have global distribution. (wikipedia.org)
  • In 1973-75, Straus researched adenoviruses as a research associate at the National Institute of Allergy and Infectious Diseases (NIAID). (wikipedia.org)
  • Many other vaccines, including those for chicken pox and rubella, are made using fetal tissue from two pregnancies terminated in the early 1960s. (wikipedia.org)
  • Researchers and clinicians from all over the world are advancing the development of a vaccine against novel human SARS-CoV-2 using various approaches. (mdpi.com)
  • Separately, MilliporeSigma plans to build a vaccine manufacturing facility in Ghana, making the country the first in sub-Saharan Africa to have a dedicated human vaccine manufacturing facility. (fiercepharma.com)
  • Even in the presence of anti-Ad5 immunity, recent murine and human studies have confirmed E2b gene-deleted Ad5 (Ad5[E1−,E2b−]) vaccines to be highly efficacious inducers of transgene-specific memory responses and significantly less toxic options than Ad5[E1−] vaccines. (asm.org)
  • Using cultures of human peripheral blood mononuclear cells (hPBMCs) derived from multiple human donors, we found that Ad5[E1−,E2b−] vaccines trigger higher levels of hPBMC proinflammatory cytokine secretion than Ad5[E1−] vaccines. (asm.org)
  • Ad5-based vaccines are attractive for a multitude of reasons, including their broad human cell tropism, relative ease of manufacturing for scaled production, and low potential for adverse side effects ( 1 ). (asm.org)
  • Although the advantages of these vaccines are abundant, there has been some hesitation toward their practical use due to the high prevalence of preexisting Ad5 immunity in the human population ( 18 - 20 ). (asm.org)
  • Whilst an effective live-attenuated vaccine is available for livestock, there is currently no licensed human RVF vaccine. (biomedcentral.com)
  • Although a highly effective live-attenuated vaccine known as Clone 13 [ 4 ] is available for livestock use in RVF-endemic countries, no licensed livestock vaccines are available for use in RVF-free areas such as Europe and there is currently no licensed human RVF vaccine. (biomedcentral.com)
  • What are the risks from HPV (Human Papillomavirus) vaccine? (cdc.gov)
  • The Food and Drug Administration has raised the recommended age to receive the vaccine for human papillomavirus, or HPV to 45. (health.mil)
  • The subject of the present invention is defective recombinant adenoviruses, characterized in that they contain a defective, non-replicable adenovirus genome into which one or more nucleic acid sequences coding for one more cytokines, in particular lymphokines, are inserted under the control of one or more promoters capable of being recognised by the polymerases of human cells, more especially of human tumor cells or of cells infiltrating these tumors. (google.com)
  • [ 141 ] These differences are likely to affect the quality of an antiviral immune response and consequently may lessen the utility of the system for testing vaccines and therapeutics targeting human HCV. (medscape.com)
  • This study tests experimental human immunodeficiency virus (HIV) vaccines that use an adenovirus as a transporter. (clinicaltrials.gov)
  • At the HVTN, many current vaccine studies are using products with a safety record that has been established in previous human trials. (wikipedia.org)
  • In 1984, after the confirmation of the etiological agent of AIDS by scientists at the U.S. National Institutes of Health and the Pasteur Institute, the United States Health and Human Services Secretary Margaret Heckler declared that a vaccine would be available within two years. (wikipedia.org)
  • In 2010, scientists announced that they had solved the structure of the human adenovirus at the atomic level, making the largest high-resolution model ever. (wikipedia.org)
  • Currently no DNA vaccines have been approved for human use. (wikipedia.org)
  • HEK 293 cells were generated in 1973 by transformation of cultures of normal human embryonic kidney cells with sheared adenovirus 5 DNA in Alex van der Eb's laboratory in Leiden, the Netherlands. (wikipedia.org)
  • Graham and coworkers provided evidence that HEK 293 cells and other human cell lines generated by adenovirus transformation of human embryonic kidney cells have many properties of immature neurons, suggesting that the adenovirus preferentially transformed a neuronal lineage cell in the original kidney culture. (wikipedia.org)
  • Adenoviruses transform neuronal lineage cells much more efficiently than typical human kidney epithelial cells. (wikipedia.org)
  • This is a timeline of the development of prophylactic human vaccines. (wikipedia.org)
  • Based on research done investigating the spread of acute respiratory distress syndrome in groups of Army recruits, Ginsberg's research on the protein structure of adenovirues led to the development of gene therapy in which working copies of genes can be implanted into the human body by way of genetically modified adenoviruses. (wikipedia.org)
  • ABC News reported on April 1, 2006 that "Beginning in late 1997, the human trials have tested 30 different vaccines, all pegged to the H5N1 virus. (wikipedia.org)
  • A combination of the vaccine with PD-1 blocking antibody significantly improved survival of the animals, with 80 % of mice remaining tumour-free. (medworm.com)
  • The subdomain of the hemagglutinin that is targeted by FI6, namely the stalk domain, was actually successfully used earlier as universal influenza virus vaccine by Peter Palese's research group at Mount Sinai School of Medicine. (wikipedia.org)
  • Although preventive measures and the development of drugs have provided some relief from the burden of malaria, dengue, and HIV, the US military continues to fund research and development of prophylactic vaccines that will contribute to force health protection and global health. (frontiersin.org)
  • Ad14 (for adenovirus serotype 14 ), has caused at least 140 illnesses in New York, Oregon, Texas and Washington, according to a report from the Centers for Disease Control and Prevention. (wikipedia.org)