Vaccines used to prevent infection by any virus from the family ADENOVIRIDAE.
Species of the genus MASTADENOVIRUS, causing a wide range of diseases in humans. Infections are mostly asymptomatic, but can be associated with diseases of the respiratory, ocular, and gastrointestinal systems. Serotypes (named with Arabic numbers) have been grouped into species designated Human adenovirus A-F.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses.
Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.
Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.
Proteins transcribed from the E1A genome region of ADENOVIRUSES which are involved in positive regulation of transcription of the early genes of host infection.
Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.
Two or more vaccines in a single dosage form.
Virus diseases caused by the ADENOVIRIDAE.
Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.
Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.
Proteins encoded by adenoviruses that are synthesized prior to, and in the absence of, viral DNA replication. The proteins are involved in both positive and negative regulation of expression in viral and cellular genes, and also affect the stability of viral mRNA. Some are also involved in oncogenic transformation.
Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression.
Proteins transcribed from the E3 region of ADENOVIRUSES but not essential for viral replication. The E3 19K protein mediates adenovirus persistence by reducing the expression of class I major histocompatibility complex antigens on the surface of infected cells.
Proteins transcribed from the E4 region of ADENOVIRUSES. The E4 19K protein transactivates transcription of the adenovirus E2F protein and complexes with it.
Vaccines consisting of one or more antigens that stimulate a strong immune response. They are purified from microorganisms or produced by recombinant DNA techniques, or they can be chemically synthesized peptides.
Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.
Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.
Vaccines made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents.
The very first viral gene products synthesized after cells are infected with adenovirus. The E1 region of the genome has been divided into two major transcriptional units, E1A and E1B, each expressing proteins of the same name (ADENOVIRUS E1A PROTEINS and ADENOVIRUS E1B PROTEINS).
Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.
Vaccines or candidate vaccines used to prevent infection with NEISSERIA MENINGITIDIS.
Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced.
Species of the genus MASTADENOVIRUS that causes fever, edema, vomiting, and diarrhea in dogs and encephalitis in foxes. Epizootics have also been caused in bears, wolves, coyotes, and skunks. The official species name is Canine adenovirus and it contains two serotypes.
A live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had measles or been immunized with live measles vaccine and have no serum antibodies against measles. Children are usually immunized with measles-mumps-rubella combination vaccine. (From Dorland, 28th ed)
A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)
Immunoglobulins produced in response to VIRAL ANTIGENS.
Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.
Vaccines or candidate vaccines containing antigenic polysaccharides from Haemophilus influenzae and designed to prevent infection. The vaccine can contain the polysaccharides alone or more frequently polysaccharides conjugated to carrier molecules. It is also seen as a combined vaccine with diphtheria-tetanus-pertussis vaccine.
An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.
A suspension of formalin-inactivated poliovirus grown in monkey kidney cell tissue culture and used to prevent POLIOMYELITIS.
Vaccines or candidate vaccines used to prevent infection with ROTAVIRUS.
Vaccines or candidate vaccines used to prevent infection with VIBRIO CHOLERAE. The original cholera vaccine consisted of killed bacteria, but other kinds of vaccines now exist.
Proteins transcribed from the E2 region of ADENOVIRUSES. Several of these are required for viral DNA replication.
Vaccines used to prevent TYPHOID FEVER and/or PARATYPHOID FEVER which are caused by various species of SALMONELLA. Attenuated, subunit, and inactivated forms of the vaccines exist.
A live VACCINIA VIRUS vaccine of calf lymph or chick embryo origin, used for immunization against smallpox. It is now recommended only for laboratory workers exposed to smallpox virus. Certain countries continue to vaccinate those in the military service. Complications that result from smallpox vaccination include vaccinia, secondary bacterial infections, and encephalomyelitis. (Dorland, 28th ed)
Vaccines or candidate vaccines used to prevent or treat TUBERCULOSIS.
A genus of ADENOVIRIDAE that infects MAMMALS including humans and causes a wide range of diseases. The type species is Human adenovirus C (see ADENOVIRUSES, HUMAN).
Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.
A live, attenuated varicella virus vaccine used for immunization against chickenpox. It is recommended for children between the ages of 12 months and 13 years.
A vaccine consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and whole-cell PERTUSSIS VACCINE. The vaccine protects against diphtheria, tetanus, and whooping cough.
Vaccines used to prevent infection by MUMPS VIRUS. Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. Children are usually immunized with measles-mumps-rubella combination vaccine.
Schedule giving optimum times usually for primary and/or secondary immunization.
Deoxyribonucleic acid that makes up the genetic material of viruses.
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Vaccines or candidate vaccines used to prevent infection with hepatitis A virus (HEPATOVIRUS).
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Species of the genus MASTADENOVIRUS, causing neurological disease in pigs.
Proteins that form the CAPSID of VIRUSES.
A combined vaccine used to prevent MEASLES; MUMPS; and RUBELLA.
A genus of ADENOVIRIDAE that infects birds. The type species is FOWL ADENOVIRUS A.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Vaccines or candidate vaccines used to prevent ANTHRAX.
Vaccines or candidate vaccines used to prevent STREPTOCOCCAL INFECTIONS.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
Established cell cultures that have the potential to propagate indefinitely.
The type species of the genus AVIADENOVIRUS, family ADENOVIRIDAE, an oncogenic virus of birds. This is also called CELO virus for chick embryo lethal orphan virus.
Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.
Vaccines using VIROSOMES as the antigen delivery system that stimulates the desired immune response.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Any vaccine raised against any virus or viral derivative that causes hepatitis.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)
Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Vaccine used to prevent YELLOW FEVER. It consists of a live attenuated 17D strain of the YELLOW FEVER VIRUS.
A suspension of killed Yersinia pestis used for immunizing people in enzootic plague areas.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
Vaccines or candidate vaccines designed to prevent SAIDS; (SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME); and containing inactivated SIMIAN IMMUNODEFICIENCY VIRUS or type D retroviruses or some of their component antigens.
Suspensions of attenuated or killed fungi administered for the prevention or treatment of infectious fungal disease.
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.
Proteins found in any species of virus.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
A live attenuated virus vaccine of duck embryo or human diploid cell tissue culture origin, used for routine immunization of children and for immunization of nonpregnant adolescent and adult females of childbearing age who are unimmunized and do not have serum antibodies to rubella. Children are usually immunized with measles-mumps-rubella combination vaccine. (Dorland, 28th ed)
Vaccines that are produced by using only the antigenic part of the disease causing organism. They often require a "booster" every few years to maintain their effectiveness.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.
Vaccines or candidate vaccines used to prevent infection with SALMONELLA. This includes vaccines used to prevent TYPHOID FEVER or PARATYPHOID FEVER; (TYPHOID-PARATYPHOID VACCINES), and vaccines used to prevent nontyphoid salmonellosis.
Vaccines using supra-molecular structures composed of multiple copies of recombinantly expressed viral structural proteins. They are often antigentically indistinguishable from the virus from which they were derived.
Use of attenuated VIRUSES as ANTINEOPLASTIC AGENTS to selectively kill CANCER cells.
Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.
Delivery of medications through the nasal mucosa.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.
The functional hereditary units of VIRUSES.
The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.
Simultaneous inflammation of the cornea and conjunctiva.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.
Vaccines or candidate vaccines used to prevent infection with CYTOMEGALOVIRUS.
Organized services to administer immunization procedures in the prevention of various diseases. The programs are made available over a wide range of sites: schools, hospitals, public health agencies, voluntary health agencies, etc. They are administered to an equally wide range of population groups or on various administrative levels: community, municipal, state, national, international.
Antibody-mediated immune response. Humoral immunity is brought about by ANTIBODY FORMATION, resulting from TH2 CELLS activating B-LYMPHOCYTES, followed by COMPLEMENT ACTIVATION.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A combined vaccine used to prevent infection with diphtheria and tetanus toxoid. This is used in place of DTP vaccine (DIPHTHERIA-TETANUS-PERTUSSIS VACCINE) when PERTUSSIS VACCINE is contraindicated.
Vaccines used to prevent POLIOMYELITIS. They include inactivated (POLIOVIRUS VACCINE, INACTIVATED) and oral vaccines (POLIOVIRUS VACCINE, ORAL).
Substances elaborated by viruses that have antigenic activity.
Vaccines or candidate vaccines used to prevent or treat both enterotoxigenic and enteropathogenic Escherichia coli infections.
Vaccines or candidate vaccines used to prevent infection with WEST NILE VIRUS.
Vaccines or candidate vaccines used to prevent bacillary dysentery (DYSENTERY, BACILLARY) caused by species of SHIGELLA.
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
The outer protein protective shell of a virus, which protects the viral nucleic acid.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Inflammation, often mild, of the conjunctiva caused by a variety of viral agents. Conjunctival involvement may be part of a systemic infection.
An attenuated vaccine used to prevent and/or treat HERPES ZOSTER, a disease caused by HUMAN HERPESVIRUS 3.
Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.
The forcing into the skin of liquid medication, nutrient, or other fluid through a hollow needle, piercing the top skin layer.
A bacterial vaccine for the prevention of brucellosis in man and animal. Brucella abortus vaccine is used for the immunization of cattle, sheep, and goats.
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.
Ribonucleic acid that makes up the genetic material of viruses.
Vaccines or candidate vaccines used to prevent infection by any virus from the family HERPESVIRIDAE.
Vaccines or candidate vaccines used to prevent infection with LEISHMANIA.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc.
Substances elaborated by bacteria that have antigenic activity.
Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.
Aluminum metal sulfate compounds used medically as astringents and for many industrial purposes. They are used in veterinary medicine for the treatment of ulcerative stomatitis, leukorrhea, conjunctivitis, pharyngitis, metritis, and minor wounds.
Vaccines or candidate vaccines used to prevent infection with viruses from the genus SIMPLEXVIRUS. This includes vaccines for HSV-1 and HSV-2.
The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.
Protection conferred on a host by inoculation with one strain or component of a microorganism that prevents infection when later challenged with a similar strain. Most commonly the microorganism is a virus.
Vaccines or candidate vaccines used to prevent infection with RESPIRATORY SYNCYTIAL VIRUSES.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Vaccines or candidate vaccines used to prevent infection with Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE).
Administration of a vaccine to large populations in order to elicit IMMUNITY.
Elements of limited time intervals, contributing to particular results or situations.
Vaccines or candidate vaccines used to prevent conception.
A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Infection with any of the rotaviruses. Specific infections include human infantile diarrhea, neonatal calf diarrhea, and epidemic diarrhea of infant mice.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
Process of growing viruses in live animals, plants, or cultured cells.
Vaccines or candidate vaccines derived from edible plants. Transgenic plants (PLANTS, TRANSGENIC) are used as recombinant protein production systems and the edible plant tissue functions as an oral vaccine.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Active immunization where vaccine is administered for therapeutic or preventive purposes. This can include administration of immunopotentiating agents such as BCG vaccine and Corynebacterium parvum as well as biological response modifiers such as interferons, interleukins, and colony-stimulating factors in order to directly stimulate the immune system.
INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.
Proteins prepared by recombinant DNA technology.
Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. Helper and satellite may be of the same or different genus.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Nonsusceptibility to the pathogenic effects of foreign microorganisms or antigenic substances as a result of antibody secretions of the mucous membranes. Mucosal epithelia in the gastrointestinal, respiratory, and reproductive tracts produce a form of IgA (IMMUNOGLOBULIN A, SECRETORY) that serves to protect these ports of entry into the body.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
Vaccines or candidate vaccines used to prevent PSEUDORABIES (Aujeszky's disease), a herpesvirus of swine and other animals.
Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-galactosides. Deficiency of beta-Galactosidase A1 may cause GANGLIOSIDOSIS, GM1.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).
A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.
A genus of the family PICORNAVIRIDAE whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated "human enterovirus".
The relationship between an elicited ADAPTIVE IMMUNE RESPONSE and the dose of the vaccine administered.
A cell line derived from cultured tumor cells.
A subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 1. The H5N1 subtype, frequently referred to as the bird flu virus, is endemic in wild birds and very contagious among both domestic (POULTRY) and wild birds. It does not usually infect humans, but some cases have been reported.
A highly contagious infectious disease caused by MORBILLIVIRUS, common among children but also seen in the nonimmune of any age, in which the virus enters the respiratory tract via droplet nuclei and multiplies in the epithelial cells, spreading throughout the MONONUCLEAR PHAGOCYTE SYSTEM.
Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.
Species of the genus INFLUENZAVIRUS B that cause HUMAN INFLUENZA and other diseases primarily in humans. Antigenic variation is less extensive than in type A viruses (INFLUENZA A VIRUS) and consequently there is no basis for distinct subtypes or variants. Epidemics are less likely than with INFLUENZA A VIRUS and there have been no pandemics. Previously only found in humans, Influenza B virus has been isolated from seals which may constitute the animal reservoir from which humans are exposed.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Vaccines for the prevention of diseases caused by various species of Rickettsia.
An acute, highly contagious, often fatal infectious disease caused by an orthopoxvirus characterized by a biphasic febrile course and distinctive progressive skin eruptions. Vaccination has succeeded in eradicating smallpox worldwide. (Dorland, 28th ed)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Vaccines or candidate vaccines used to prevent infection with parainfluenza viruses in humans and animals.
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.

A novel chimpanzee adenovirus vector with low human seroprevalence: improved systems for vector derivation and comparative immunogenicity. (1/6)

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Circumventing antivector immunity by using adenovirus-infected blood cells for repeated application of adenovirus-vectored vaccines: proof of concept in rhesus macaques. (2/6)

Adenovirus has been extensively exploited as a vector platform for delivering vaccines. However, preexisting antiadenovirus immunity is the major stumbling block for application of adenovirus-vectored vaccines. In this study, we found that freshly isolated peripheral blood mononuclear cells (PBMCs), mostly CD14(+) cells, from adenovirus serotype 5 (Ad5)-seropositive primates (humans and rhesus macaques) can be efficiently infected with Ad5 in vitro. On the basis of this observation, a novel strategy based on adenoviral vector-infected PBMC (AVIP) immunization was explored to circumvent antivector immunity. Autologous infusion of Ad5-SIVgag-infected PBMCs elicited a strong Gag-specific cellular immune response but induced weaker Ad5-neutralizing antibody (NAb) in Ad5-seronegative macaques than in macaques intramuscularly injected with Ad5-SIVgag. Moreover, Ad5-seropositive macaques receiving multiple AVIP immunizations with Ad5-SIVenv, Ad5-SIVgag, and Ad5-SIVpol vaccines elicited escalated Env-, Gag-, and Pol-specific immune responses after each immunization that were significantly greater than those in macaques intramuscularly injected with these Ad5-SIV vaccines. After challenged intravenously with a highly pathogenic SIVmac239 virus, macaques receiving AVIP immunization demonstrated a significant reduction in viral load at both the peak time and set-point period compared with macaques without Ad5-SIV vaccines. Our study warranted further research and development of the AVIP immunization as a platform for repeated applications of adenovirus-vectored vaccines.  (+info)

Modification of one epitope-flanking amino acid allows for the induction of friend retrovirus-specific CD8+ T cells by Adenovirus-based immunization. (3/6)

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Targeting the genital tract mucosa with a lipopeptide/recombinant adenovirus prime/boost vaccine induces potent and long-lasting CD8+ T cell immunity against herpes: importance of MyD88. (4/6)

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Incidence of acute respiratory illnesses among enlisted service members during their first year of military service: did the 2011 resumption of adenovirus vaccination of basic trainees have an effect? (5/6)

This study analyzed the incidence of acute respiratory illnesses (i.e., upper respiratory illnesses, bronchitis and bronchiolitis, and pneumonias) during the first 12 months of service among enlisted members of the active components of the U.S. Armed Forces. Subjects were assigned to cohorts designated 1999 through 2012 corresponding to the years during which they entered service. The objective was to determine if the late 2011 resumption of administration of adenovirus vaccines to basic trainees was associated with a reduction in acute respiratory illnesses among the 2012 cohort. Because acute respiratory illness rates were considerably higher during the first three months than the rest of the first year of service, rates during the first three months and the next nine months of service were compared separately among the cohorts. In the 2012 compared to the prior year cohorts, incidence rates of hospitalizations for pneumonia and of outpatient diagnoses of the other two acute respiratory illness types of interest were lower during the first three months but not the next nine months of enlisted service. The findings suggest a protective effect of adenovirus vaccines during recruit training. Reasons for cautious interpretation of the results are discussed.  (+info)

A single intraduodenal administration of human adenovirus 40 vaccine effectively prevents anaphylactic shock. (6/6)

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Substantial protection can be provided against the pre-erythrocytic stages of malaria by vaccination first with an adenoviral and then with an modified vaccinia virus Ankara (MVA) poxviral vector encoding the same ME.TRAP transgene. We investigated whether the two vaccine compon ents adenovirus (Ad) and MVA could be coinjected as a mixture to enhance protection against malaria. A single-shot mixture at specific ratios of Ad and MVA (AdMVA) enhanced CD8 ++ T cell-dependant protection of mice against challenge with Plasmodium berghei. Moreover, the degree of protection could be enhanced after homologous boosting with the same AdMVA mixture to levels comparable with classic heterologous Ad prime-MVA boost regimes. The mixture increased transgene-specific responses while decreasing the CD8 ++ T cell antivector immunity compared to each vector used alone, particularly against the MVA backbone. Mixed vector immunization led to increased early circulating interferon-γ (IFN-γ) response levels and altered
In order to halt the HIV pandemic an effective vaccine must be developed. In this study, investigators will examine the safety and immune response to a prime-boost strategy using two different vaccine regimens, NYVAC-B and rAd5.. Eighty participants will be recruited to this study. Participants will be randomly assigned to one of four different groups (study arms). Each group will receive both study vaccines and placebo but at different times. All NYVAC-B vaccine doses will be the same, but the doses of the rAD5 vaccine will differ from group to group. Some participants in each group will receive only placebo. Participants will visit the study clinic about 13 times over the course of 12 months and be contacted for follow-up for 4 years.. All study injections will be given in the same upper arm area. There will be a total of four injections during the course of the study. After each injection, participants will need to stay in the clinic for at least 25 minutes to check for any adverse reactions. ...
In order to halt the HIV pandemic an effective vaccine must be developed. In this study, investigators will examine the safety and immune response to a prime-boost strategy using two different vaccine regimens, NYVAC-B and rAd5.. Eighty participants will be recruited to this study. Participants will be randomly assigned to one of four different groups (study arms). Each group will receive both study vaccines and placebo but at different times. All NYVAC-B vaccine doses will be the same, but the doses of the rAD5 vaccine will differ from group to group. Some participants in each group will receive only placebo. Participants will visit the study clinic about 13 times over the course of 12 months and be contacted for follow-up for 4 years.. All study injections will be given in the same upper arm area. There will be a total of four injections during the course of the study. After each injection, participants will need to stay in the clinic for at least 25 minutes to check for any adverse reactions. ...
DIFFERENCES IN INSULIN, GROWTH-HORMONE AND PANCREATIC ENZYME SECRETION AFTER INTRAVENOUS AND INTRADUODENAL ADMINISTRATION OF MIXED AMINO-ACIDS IN ...
A basic trainee has been hospitalized since Feb. 11. Fort Benning is investigating whether officials mishandled the medical response to the outbreak.
In the context of clinicalgene transfer using viral vectors, the risk of memory antivector immunity is often poorly appreciated. The immunological past of the patient, the site of injection, and the...
Antivector immunity continues to be recognized as a potential caveat of using virus-based vaccines. ability to stimulate humoral, cellular, and mucosal immune responses. Alphaviruses belong to the family and contain a positive-sense, single-stranded RNA genome of approximately 12 kb encoding four nonstructural proteins in the 5 two-thirds of the genome, followed by a strong subgenomic promoter that directs expression of the viral structural proteins in the 3 one-third of the genome. Upon contamination of a cell, the alphavirus nonstructural proteins are translated to create a polymerase complicated instantly, which initiates replication from the viral genome and high-level transcription through the subgenomic promoter and translation from the downstream structural proteins gene products, that leads to set up of progeny viral contaminants. Vaccine delivery vectors predicated on alphaviruses have already been created from Semliki Forest pathogen (SFV) (27), Sindbis (SIN) pathogen (7, 53), ...
Ten researchers from the CDCs NCIRD released a paper arguing that because the immune-boosting effects of breastmilk, nursing mothers should delay breastfeeding their infants.
Ten researchers from the CDCs NCIRD released a paper arguing that because the immune-boosting effects of breastmilk, nursing mothers should delay breastfeeding their infants.
Simian virus 40 (SV40) was an accidental contaminant of vaccines produced in monkey kidney tissue cultures in the 1950s and early 1960s, including a parenteral adenovirus vaccine given to several hundred thousand US military recruits. Detection of SV40 DNA in tumor tissues by some laboratories suggests that SV40 contributes to human cancers. To determine if entry into US Army service during periods of administration of SV40-contaminated adenovirus vaccine was associated with an increased risk of cancer, the authors conducted a case-control study of cancer occurring in male Army veterans who entered service in 1959-1961. Cases of brain tumors (n = 181), mesothelioma (n = 10), and non-Hodgkins lymphoma (n = 220) were identified through a Veterans Administration hospital discharge database, as were colon cancer and lung cancer controls (n = 221). Exposure to adenovirus vaccine was assigned on the basis of known periods of adenovirus vaccine administration and dates of Army entry obtained for ...
While chimpanzees can give insight into common illnesses, they can also be integral in the development of vaccines. Adenoviruses (Ads), a type of double-stranded DNA virus that broadly infects vertebrates, have historically been used as vaccine vectors.[65] Although human serotypes of adenovirus (AdHus) have frequently been used, studies of chimpanzee adenoviruses (AdCs) are rising in prevalence due to a number of apparent benefits, including increased immunogenicity and a decrease in neutralizing cell responses in comparison to human adenoviral vectors.[66] [67] Chimpanzee adenovirus vectors have been developed in response to a number of pervasive and otherwise common diseases; in response to the 2016 Ebola outbreak, for example, researchers developed AdCs that successfully activated memory T-cell responses, distributed equally between CD4 and CD8 T-cells.[68][69] In January 2017, the Coalition for Epidemic Preparedness Innovations (CEPI) was formed with the purpose of creating and stockpiling ...
While chimpanzees can give insight into common illnesses, they can also be integral in the development of vaccines. Adenoviruses (Ads), a type of double-stranded DNA virus that broadly infects vertebrates, have historically been used as vaccine vectors.[21] Although human serotypes of adenovirus (AdHus) have frequently been used, studies of chimpanzee adenoviruses (AdCs) are rising in prevalence due to a number of apparent benefits, including increased immunogenicity and a decrease in neutralizing cell responses in comparison to human adenoviral vectors.[21] [23] Chimpanzee adenovirus vectors have been developed in response to a number of pervasive and otherwise common diseases; in response to the 2016 Ebola outbreak, for example, researchers developed AdCs that successfully activated memory T-cell responses, distributed equally between CD4 and CD8 T-cells.[21] [23] In January 2017, the Coalition for Epidemic Preparedness Innovations (CEPI) was formed with the purpose of creating and stockpiling ...
Rogers et al., 2001: Rogers WO, Baird JK, Kumar A, Tine JA, Weiss W, Aguiar JC, Gowda K, Gwadz R, Kumar S, Gold M, Hoffman SL. Multistage multiantigen heterologous prime boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques. Infection and immunity. 2001; 69(9); 5565-5572. [PubMed: 11500430 ...
Vaxzevria Vaccine is used to prevent coronavirus disease 2019 (COVID-19) in people from 18 years of age. It has been designed to prepare the immune system to identify and combat the coronavirus SARS-CoV-2 causing COVID-19.. The vaccine is made up of a chimpanzee adenovirus (ChAdOx1 - Chimpanzee Adenovirus Oxford 1) that is unable to replicate and that has been modified to contain the genetic information for producing the SARS-CoV-2 spike protein.. The viral vector technology used for this vaccine has already been successfully tested and has been employed in the prevention of other diseases.. ...
7. Heres the scary part: Each tablet contains albumin, a derivative of human blood. And, a theoretical risk for transmission of Creutzfeld-Jakob disease, which is a fatal brain disease commonly referred to as human mad-cow disease. However, the vaccine package insert notes that no cases of CJD have been identified from human albumin. Clearly, we need to be concerned about those vaccines that contain human or bovine (cow) albumin, or are made with blood products derived from cattle (like fetal calf serum). To the extent that this information is available, these components are listed in Catherines new book, Vaccination Voodoo, What YOU Dont Know About Vaccines. Furthermore, could there be a possibility of homologous recombination? Homologous recombination is conserved across all three domains of life as well as viruses, suggesting that it is a nearly universal biological mechanism. [5 ...
Re-imagining discovery and access to research: grants, datasets, publications, citations, clinical trials, patents and policy documents in one place.
Human sera from the United States, Thailand, and sub-Saharan Africa and chimpanzee sera were tested for neutralizing antibodies to 3 chimpanzee adenoviruses. Antibodies were more common in humans residing in sub-Saharan Africa than in humans living in the United States or Thailand. This finding suggests cross-species transmission of chimpanzee adenoviruses ...
Effects of ,I,Saiko-ka-ryukotsu-borei-to,/I, (SRBT) on theophylline-induced tachycardia in anesthetized rats and theophylline-induced locomotion and convulsions in mice were examined. An intraduodenal administration of SRBT (1 g/kg) prevented theophylline (5 mg/kg, i.v.)-induced tachycardia in rats. SRBT also attenuated an increase in arterial blood pressure with a slow reduction in heart rate of rats treated with theophylline, with no influence on the plasma level of theophylline. However, SRBT did not change the beating rate of right atrium isolated from rats in the absence or presence of theophylline or isoproterenol. The locomotor activity of theophylline in mice was reduced by the treatment with SRBT. Furthermore, the latency of convulsions in mice induced by administration of theophylline at a higher dose (240 mg/kg, i.p.) was prolonged by treatment with SRBT (1 g/kg, p.o.) and seven out of fifteen mice were saved from death due to convulsions. These results suggest that ...
0139] [0140]Aboubakar, M., 1999. Physico-chemical characterization of insulin-loaded poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization. International Journal of Pharmaceutics 183, 63-66. [0141]Aftabrouchard, D. & E. Doelker, 1992. Preparation methods for biodegradable microparticles loaded with water- soluble drugs. S. T. P. Pharma Sciences 2, 365-380. [0142]Aiedeh, K., E. Gianasi, I. Orienti & V. Zecchi, 1997. Chitosan microcapsules as controlled release systems for insulin. Journal of Microencapsulation 14, 567-576. [0143]Al Achi, A. & R. Greenwood, 1993a. Human insulin binding to erythrocyte-membrane. Drug Development of Industrial Pharmacy 19, 673-684. [0144]Al Achi, A. & R. Greenwood, 1993b. Intraduodenal administration of biocarrier-insulin systems. Drug Development Industrial of Pharmacy 19, 1303-1315. [0145]Al Achi, A. & R. Greenwood, 1994. Human insulin absorption from the intestine in diabetic rats. Drug Development of Industrial Pharmacy 20, 2333-2339. ...
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Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yales SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions.
In fact, Ive been so excited, Ive planned so that I can cross off things. The witch can reduce irritation, itching and speed healing time. Enamel fillers, inserted into the depleted areas of her teeth, and costing £50, were her only option. But if it is not treated, it can advance to periodontitis (pair-ee-oh-don-TEYE-tuhss). . Dysfunction Type 2 Diabetes Warning Signs. But major apthous ulcers, defined as larger than 10 mm in size, can take more than a month to heal and can cause scarring when they finally do heal.. Each guided climb Dating directly with ivillage for 3 12 hours and wants to Provide insight! And you might have trouble swallowing or difficulty speaking without the lubrication that saliva provides. Gum recession causes the formation of gaps or pockets between the teeth and they become the perfect surrounding for bacteria. If you pop it could spread the virus so best to leave to heal. Do you think your cat may have been bitten by an insect, had a reaction…now it is scabbed ...
Interpretive Summary: Technical Abstract: Few effective intervention tools are available today to control FMD outbreaks. These include culling and slaughter of all animals in infected and neighboring contact premises and strict quarantines of the affected areas. These measures lead to massive accumulation of thousands of animal carcasses for disposal with the consequent disruption of commerce, tourism and transportation. Vaccination has been proposed as a tool to decrease susceptibility of animal populations in ring-vaccination schemes. Current vaccines have been designed and tested for protection at 3-4 weeks post-vaccination, creating a window of susceptibility in the vaccinated population. Previous experiments at PIADC have shown that recombinant Adenovirus-vectored FMD empty capsid (VLP) can protect swine and bovine against direct FMDV challenge by 7 days post vaccination. In addition Adenovirus-vectored porcine interferon can protect swine against FMD challenge in as little as 24 hours and ...
To elucidate the first pass metabolism of the dopamine prodrug N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine (TA-870) in the small intestine and liver of dogs, the blood and plasma concentrations of unchanged TA-870 and metabolites in the gastroduodenal vein, portal vein, hepatic vein, and abdominal aorta were measured by HPLC after intraduodenal administration of TA-870. In addition, an in vitro metabolic study of TA-870 was carried out using liver, small intestinal wall, and blood homogenates of dogs. The order of maximal concentration (Cmax 0-30 min) in gastroduodenal blood or plasma was unchanged TA-870 greater than deethoxycarbonylated TA-870 (DEC-TA-870) greater than conjugated dopamine greater than free dopamine (DA) greater than free homovanillic acid (HVA) greater than free 3,4-dihydroxyphenylacetic acid (DOPAC). This result showed that the main pathway of metabolism in the small intestine is catechol ester hydrolysis and minor pathways are amido hydrolysis, oxidative ...
This article tells consumers about acute respiratory illness and how it is diagnosed, including what imaging tests they may need to have.
Rhedin S, Lindstrand A, Rotzén-Östlund M, et al. Clinical utility of PCR for common viruses in acute respiratory illness. Pediatrics. 2014 Mar;133(3):e538-45. Full-text for Childrens and Emory users. BACKGROUND: Acute respiratory illness (ARI) accounts for a large proportion of all visits to pediatric health facilities. Quantitative real-time polymerase chain reaction (qPCR) analyses allow sensitive detection of viral nucleic…
Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yales SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions.
Background: Nearly 3 million people worldwide are coinfected with HIV and HCV. Affordable strategies for prevention are needed. We developed a novel vaccination regimen involving replication-defective and serologically distinct chimpanzee adenovirus (ChAd3, ChAd63) vector priming followed by modified vaccinia Ankara (MVA) boosts, for simultaneous delivery of HCV non-structural (NSmut) and HIV-1 conserved (HIVconsv) region immunogens. Methods: We conducted a phase I trial in which 33 healthy volunteers were sequentially enrolled and vaccinated via the intramuscular route as follows: 9 received ChAd3-NSmut [2.5 × 1010 vp] and MVA-NSmut [2 × 108 pfu] at weeks 0 and 8, respectively; 8 received ChAdV63.HIVconsv [5 × 1010 vp] and MVA.HIVconsv [2 × 108 pfu] at the same interval; 16 were co-primed with ChAd3-NSmut [2.5 × 1010 vp] and ChAdV63.HIVconsv [5 × 1010 vp] followed at week 8 by MVA-NSmut and MVA.HIVconsv [both 1 × 108 pfu]. Immunogenicity was assessed using peptide pools in ex vivo ELISpot and
I clicked & clicked my Combat Boots together & said Theres no place like home, theres no place like home,, Pooooooooooooooffffffffffffff .....17 days later .... here I am Home..... I was so happy to arrive last night, late, but HOME!. I slept in my bed, with my sheets, snuggled up to The Better Half on my left & our fuzzy 4 legged creature on my right, I am home!. I am an ANCOC Graduate!!. Thank You, Thank You.... To those of you who are Military,, you understand, To you all civilians, Its like receiving a degree, after years and years of studying. . . . Its like crossing a finish line!!. I took pictures of my cell ~ I mean Barracks ~ they were accidentally deleted...I had a basic trainee tell me a few weeks ago Being in Basic Training ..was like being in prison, I asked her ..Have you been in prison?.. NO She said: Then how would she know..?!!?!!?!!. That got me to thinking, One of my classmates is a prison guard, I came into class one day and asked him,, Do prisoners have more ...
Tweets about Acute Respiratory Illness - NowTrending.HHS.gov is tracking disease trends and terms on twitter 140 characters at a time. The Now Trending 2012 HHS/ASPR app competition winner.
Tweets about Acute Respiratory Illness - NowTrending.HHS.gov is tracking disease trends and terms on twitter 140 characters at a time. The Now Trending 2012 HHS/ASPR app competition winner.
Searle, C E. and Jones, E L., Effects of repeated applications of two semi-permanent hair dyes to the skin of a and dbaf mice. (1977). Subject Strain Bibliography 1977. 151 ...
UK drugmaker AstraZeneca says it has expanded a deal with cell therapy firm Oxford Biomedica to increase production capacity for its potential vaccine. Julian Satterthwaite reports.
The Oxford / AstraZeneca vaccine does not use the revolutionary genetic technology of mRNA or messenger RNA like Pfizer and Moderna, but the more traditional virus-vector type that takes as a carrier another virus (a chimpanzee adenovirus) although genetically modified and adapted to combat Covid-19.. However, it has been criticized due to the confusion in the interim results of clinical trials. The British laboratory announced in November that its vaccine had an average efficacy of 70%, compared to more than 90% for the Pfizer / BioNTech and Moderna vaccines.. The efficacy of the AstraZeneca / Oxford vaccine was 90% for volunteers who received a half dose first and then a full dose one month later, but only 62% for another group that was more frequently vaccinated with two full doses with a month difference.. The half-dose injection was, in fact, due to an error and only a small group had followed the second protocol, which had raised concern, and led the company to announce on November 26 ...
Acute respiratory illness is the leading cause of asthma exacerbations yet the mechanisms underlying this association remain unclear. To address the deficiencies in our understanding of the molecular events characterizing acute respiratory illness-induced asthma exacerbations, we undertook a transcriptional profiling study of the nasal mucosa over the course of acute respiratory illness amongst individuals with a history of asthma, allergic rhinitis and no underlying respiratory disease. Transcriptional profiling experiments were performed using the Agilent Whole Human Genome 4X44K array platform. Time point-based microarray and principal component analyses were conducted to identify and distinguish acute respiratory illness-associated transcriptional profiles over the course of our study. Gene enrichment analysis was conducted to identify biological processes over-represented within each acute respiratory illness-associated profile, and gene expression was subsequently confirmed by quantitative
We investigated a possible role of endogenous secretin and cholecystokinin (CCK) in inhibition of gastric acid secretion induced by intraduodenal administration of oleic acid in rats. Intraduodenal ad
For most healthy adults, seasonal viruses are not generally life-threatening. But as youve seen in the news, respiratory disease pandemics, such as those caused by coronaviruses or influenza, are something else. They often involve new strains of viruses to which people have developed no immunity. These kinds of viruses can spread quickly and widely, and they can pose a major global health threat. Thats why you need to know about acute respiratory illness pandemics and how to prepare for them. The main objective of this course is to make you aware of the risks of pandemics, the potential problems we could all face should we be hit with a pandemic, and the precautions you would need to take to keep you, your family, and your patients safe.. ...
Read A cluster of coxsackievirus A21 associated acute respiratory illness: the evidence of efficient transmission of CVA21, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
An acute respiratory infection is an infection that affects your normal breathing pattern. It normally starts as a viral infection inside the nose, the trachea (windpipe) or even the lungs. If the infection is not treated effectively, it can spread to the entire respiratory system.
CDC Split Type: 201208240. Write-up: Initial report was retrieved from the scientific literature on 06 September 2012. The following information is verbatim from the abstract: Meningococcal have historically caused extensive illness among members. Three successive meningococcal vaccine types were used from 1971 through 2010; overall disease incidence dropped by $g90% during this period. During 2006-2010, disease incidence of 0.38 (cases per 100,000 person-years) among members was not significantly different from the incidence of 0.26 among the age-matched general population. Of the 26 cases, 5 were fatal, 15 were vaccine failures (e.g., illness in a person who had been vaccinated), and 9 were caused by Neisseria meningitidis serogroup Y. Incidences among 17- to 19-year-old basic trainees and among were significantly higher than among comparison populations ( ...
See also: Adenovirus vaccine. Safe and effective adenovirus vaccines were developed for adenovirus serotypes 4 and 7, but were ... 2000). "Adult adenovirus infections: loss of orphaned vaccines precipitates military respiratory disease epidemics". Clin ... Enteric adenoviruses 40 and 41 cause gastroenteritis, usually in children. For some adenovirus serotypes, the clinical spectrum ... Some adenoviruses (e.g., serotypes 1, 2, 5, and 6) have been shown to be endemic in parts of the world where they have been ...
"Oral adenovirus-based vaccines: historical perspective and future opportunity". Expert Review of Vaccines, Future Drugs. 7 (1 ... The lead vaccine candidate by Vaxart is an influenza oral tablet vaccine, which showed safety and neutralizing antibody ... A 2016-17 Phase II trial of the Vaxart oral flu vaccine, VXA-A1.1, showed that the vaccine was well-tolerated and provided ... Vaxart uses enteric-coated tablets to protect the active vaccine from acidic degradation in the stomach, delivering the vaccine ...
... "items affecting adenovirus vaccine production capability; high strength, inherently fire and ballistic resistant, co-polymer ... then-president Trump said that he would invoke the Defense Production Act to produce vaccine doses, but he did not do so before ... Johnson vaccines. Nationalization Congressional Research Service, The Defense Production Act of 1950: History, Authorities, and ... www.bloomberg.com/news/articles/2020-12-08/trump-vows-to-use-defense-production-act-if-needed-for-vaccines [https://www. ...
Adenoviruses are being actively developed as vaccine vectors. A strain of canarypox virus modified to carry feline interleukin- ... If the vaccine or gene therapy fails in clinical trials, the virus can't be used again in the patient for a different vaccine ... A live vector vaccine is a vaccine that uses an organism (typically virus or bacterium) that does not cause disease to ... adenovirus vector immunity on immunogenicity and protection conferred with an adenovirus-based H5N1 influenza vaccine". PLOS ...
"Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys". Science. 349 (6245): 320-324. ... HIV vaccine, RSV vaccine and COVID-19 vaccine. Schuitemaker (1964) grew up in the Netherlands. Her mother was a bookkeeper and ... The various vaccine candidates have been tested from March 2020. In mid-May, she announced that Janssen's most hopeful vaccine ... In November 2020, Jansen Vaccines announced that the production of the COVID vaccine was delayed by several months due to the ...
Most combination vaccines for dogs contain a modified canine adenovirus type-2. CAV-2 is one of the causes of respiratory ... CAV-2 vaccine is much less likely to cause side effects than CAV-1 vaccine. One study has shown the vaccine to have a duration ... Prevention is through vaccination (ATCvet code QI07AA05 (WHO) and various combination vaccines). ... formerly called Canine adenovirus 1 (CAV-1). CAV-1 also causes disease in wolves, coyotes, and bears, and encephalitis in foxes ...
"Dna encoding ovine adenovirus (oav287) and its use as a viral vector". Google Patents. 12 December 2017. Retrieved 12 December ... "Viral Vaccines in India: An Overview". Proceedings of the National Academy of Sciences, India Section B: Biological Sciences. ... Later, he concentrated on the development of DNA vaccines and the details of the work has since been published as an article, ... Known for his studies in the fields of RNA virus replication and vaccine development, Vrati is an elected fellow of the ...
Therefore, investigators have tested new vaccines using the chimp adenovirus ChAdOx1 as a vector. For example, a vaccine for ... Morris, Susan J; Sebastian, Sarah; Spencer, Alexandra J; Gilbert, Sarah C (1 September 2016). "Simian adenoviruses as vaccine ... The vector is a chimpanzee adenovirus modified to avoid its replication. Adenoviruses are effective vectors for inducing and ... The adenovirus expressing the antigen 85A (ChAdOx1 85A), is used as vector for a tuberculosis vaccine candidate. In 2017, the ...
Adenovirus have been used to produce viral vector COVID-19 vaccines. "In four candidate COVID-19 vaccines... Ad5... serves as ... Adenoviruses Stanford University-Adenoviruses Adenoviruses General Concepts General information on Adenovirus DNA virus ... Currently, there is no adenovirus vaccine available to the general public, but a vaccine is available for the United States ... The Johnson & Johnson COVID-19 vaccine uses modified recombinant adenovirus type-26 (Ad26). Recombinant adenovirus type-5 (Ad5 ...
"Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man". Science Translational Medicine. 4 ( ... The vaccine could be commercially available in five years. (io9) Human diseases could soon be modeled in an electronic "organ- ... Science Daily) (PLoS Med.) 7 November Canadian researchers working to develop the world's first HIV vaccine have cleared a ... Researchers at Oxford University report promising results in human trials of a prototype hepatitis C vaccine. Scientists at ...
It's a viral vector vaccine based on replication-deficient Adenovirus that causes cold in Chimpanzees. It can be stored, ... "COVID-19 vaccine Covishield gets approval from DCGI's expert panel". The Hindu. 1 January 2021. Retrieved 4 January 2021. " ... On 14 January 2021 first batches of Covaxin vaccine was despatched from the Bharat Biotech, albeit it was still in the third ... "AstraZeneca's COVID-19 vaccine authorised for emergency supply in the UK". AstraZeneca. AstraZeneca. 30 December 2020. ...
It's a viral vector vaccine based on replication-deficient Adenovirus that causes cold in Chimpanzees. It can be stored, ... "COVID-19 vaccine Covishield gets approval from DCGI's expert panel". The Hindu. 1 January 2021. Retrieved 4 January 2021. " ... On 14 January 2021 first batches of Covaxin vaccine was despatched from the Bharat Biotech, albeit it was still in the third ... "AstraZeneca's COVID-19 vaccine authorised for emergency supply in the UK". AstraZeneca. AstraZeneca. 30 December 2020. ...
It's a viral vector vaccine based on replication-deficient Adenovirus that causes cold in Chimpanzees. It can be stored, ... On 14 January 2021 first batches of Covaxin vaccine was despatched from the Bharat Biotech, albeit it was still in the third ... "AstraZeneca's COVID-19 vaccine authorised for emergency supply in the UK". AstraZeneca. AstraZeneca. 30 December 2020. ... On 12 January 2021 first batches of Covishield vaccine was despatched from the Serum Institute of India. On January 2, 2021, ...
It's a viral vector vaccine based on replication-deficient Adenovirus that causes cold in Chimpanzees. It can be stored, ... "COVID-19 vaccine Covishield gets approval from DCGI's expert panel". The Hindu. 1 January 2021. Retrieved 22 January 2021. " ... On 14 January 2021, the first batches of Covaxin vaccine were dispatched from Bharat Biotech, albeit still in the third phase ... On 12 January 2021, the first batches of Covishield vaccine were dispatched from the Serum Institute of India. On 2 January ...
One of these vaccines is being tested as a prophylactic against the acute-respiratory disease adenovirus. Another is focused on ... The BioThrax vaccines will go to the SNS. The contract will supply around 29.4 million doses of the vaccine. Additionally, the ... BioThrax (Anthrax Vaccine Adsorbed), a vaccine licensed by the U.S. Food and Drug Administration. Following a study by ... Health Canada delayed the distribution of the vaccine because a substance used in the J&J vaccines was produced at Emergent ...
"Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing ... "Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs". Mol ... Schabacker, DS; Kirschbaum, KS; Segre, M (2000). "Exploring the feasibility of an anti-idiotypic cocaine vaccine: analysis of ...
Main article: Adenovirus vaccine. In the past, US military recruits were vaccinated against two serotypes of adenovirus, with a ... Currently, there is no adenovirus vaccine available to the general public, but a vaccine is available for the United States ... matrix protein M1 on the platform of the adenovirus dodecahedron". Vaccine. 27 (52): 7385-93. doi:10.1016/j.vaccine.2009.09.021 ... Canine adenovirus 2 (CAdV-2) is one of the potential causes of kennel cough. Core vaccines for dogs include attenuated live ...
"Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine". Journal of Clinical ... In 2007, she co-founded the Vaccine Infectious Disease Institute at Fred Hutch and has served as sole director of the Vaccine ... "Fred Hutch featured in HBO documentary on HIV vaccine". Seattle Times. "Immunologic Challenges to HIV Vaccine Design". 2007-10- ... "Trivalent Adenovirus Type 5 HIV Recombinant Vaccine Primes for Modest Cytotoxic Capacity That is Greatest in Humans with ...
Reovirus vaccines are advocated (in dams or in broilers) but do not entirely solve the problem. General hygiene and correct ... Causing agents may include: viruses: reovirus (often considered as unique cause), adenoviruses, enteroviruses, rotaviruses, ...
Management strategies include developing a vaccine and improving genetic resistance to the disease. Marine mammals are also ... Many other viruses, including caliciviruses, herpesviruses, adenoviruses and parvoviruses, circulate in marine mammal ...
"Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse ... The universal flu vaccine does not need to be reformatted every year and stops people from needing a seasonal flu vaccine. Her ... On 30 December 2020, the Oxford-AstraZeneca COVID-19 vaccine she co-developed with the Oxford Vaccine Group was approved for ... "Chimpanzee Adenovirus Vaccine Provides Multispecies Protection against Rift Valley Fever". Scientific Reports. 6 (1): 20617. ...
Several intranasal vaccines have been developed that contain canine adenovirus in addition to B. bronchiseptica and canine ... Edinboro, C; Ward, M; Glickman, L (February 2004). "A Placebo-controlled Trial of Two Intranasal Vaccines to Prevent ... Prevention is by vaccinating for canine adenovirus, distemper, parainfluenza, and Bordetella. In kennels, the best prevention ... Administration of B. bronchiseptica and canine parainfluenza vaccines may then be continued routinely, especially during ...
The vaccine uses an replication-incompetent human adenovirus. In July 2020, Johnson & Johnson pledged to deliver up to 300 ... In September 2020, Johnson & Johnson started its 60,000-person Phase III adenovirus-based vaccine trial. The trial was ... Janssen Vaccines partnered with Beth Israel Deaconess Medical Center, to develop a vaccine candidate based on the same ... Maryland conflated the ingredients of two COVID-19 vaccines, causing about 15 million doses of Johnson & Johnson's vaccine to ...
"Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges". Virology. 353 (2): ... There are currently no Food and Drug Administration-approved vaccines for the prevention of MVD. Many candidate vaccines have ... "Marburg virus vaccines: Comparing classical and new approaches". Vaccine. 20 (3-4): 586-593. doi:10.1016/S0264-410X(01)00353-X ... "Clinical and Vaccine Immunology. 13 (4): 444-451. doi:10.1128/CVI.13.4.444-451.2006. PMC 1459631 . PMID 16603611.. ...
Notably, participants immune to the common cold virus adenovirus type 5 had a higher risk of HIV infection. The vaccine was ... During a randomized, double-blind clinical trial testing the efficacy of the prototype HIV vaccine called V520 there appeared ... had been stopped suspecting the higher rate of HIV infection among individuals in the vaccinated was because the vaccine ...
Vaccine[edit]. There are several H5N1 vaccines for several of the avian H5N1 varieties, but the continual mutation of H5N1 ... "Protection of Mice and Poultry from Lethal H5N1 Avian Influenza Virus through Adenovirus-Based Immunization". J. Virol. 80 (4 ... "There is no H5N1 pandemic so there can be no pandemic vaccine".[43] However, "pre-pandemic vaccines" have been created; are ... Vaccine manufacturing companies are being encouraged to increase capacity so that if a pandemic vaccine is needed, facilities ...
The hepatitis B vaccine is the first vaccine that has been established to prevent cancer (hepatocellular carcinoma) by ... The adenovirus E1B protein (55K) prevents p53 from regulating genes by binding to the site on p53 which binds to the genome.[32 ... In 2006, the U.S. Food and Drug Administration approved a human papilloma virus vaccine, called Gardasil. The vaccine protects ... The adenovirus early region 1A (E1A) is an oncoprotein which binds to Rb and can stimulate transcription and transform cells.[ ...
... adenovirus, severe acute respiratory syndrome (SARS) and measles. Chest radiographs (X-ray photographs) often show a pulmonary ... as the decrease of occult pneumonia after vaccination of children with a pneumococcal vaccine suggests. Infiltration commonly ...
Adenoviruses are among the main causes of upper respiratory tract ailments such as the common cold. Because the vaccine ... Vaccine Research Center (VRC)- Information concerning Preventive HIV vaccine research studies NIAID HIV vaccine site (DAIDS) ... Global Alliance for Vaccines and Immunization (GAVI) International AIDS Vaccine Initiative (IAVI) AIDS Vaccine Advocacy ... Adenovirus vectors and many other viral vectors currently used in HIV vaccines, will induce a rapid memory immune response ...
... oral adenovirus type 4 and type 7 vaccine, in U.S. Military recruits". Vaccine. 31 (28): 2963-2971. doi:10.1016/j.vaccine. ... Rotavirus vaccine. Rotateq, Rotarix Rubella virus. Rubella. Rubella vaccine, MMR vaccine, MMRV vaccine. Priorix, MMR II, ... Japanese encephalitis vaccine. Ixiaro, Jespect, Imojev Measles virus. Measles. Measles vaccine, MMR vaccine, MMRV vaccine. ... Varicella vaccine, Shingles vaccine, MMRV vaccine. Varivax, Zostavax, ProQuad, Priorix Tetra Variola virus. Smallpox. Smallpox ...
Vaccines - a Biography edited by Andrew W. Artenstein ISBN 978-1-4419-1107-0[page needed] ... Use of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine (Report). Centers for Disease ... Main articles: Smallpox vaccine and Edward Jenner. In 1796, Edward Jenner, a doctor and scientist who had practiced variolation ... He then derived a vaccine by altering the infectious agent so as to make it harmless and then introducing this inactivated form ...
... adenoviruses, Enteroviruses, and metapneumovirus.[12] Frequently, more than one virus is present and causing the infection.[13] ... Developing a broadly effective vaccine is very unlikely.[32] ...
Talk:Adenovirus genome. *Talk:Adenovirus serotype 14. *Talk:Adenovirus vaccine. *Talk:Adria virus ...
An adenovirus was first isolated by Rowe et al. in 1953. Two years later, Jawetz et al. published on epidemic ... 2015). Epidemiology and Prevention of Vaccine-Preventable Diseases. U.S. Dept. of Health & Human Services, Centers for Disease ... Vaccination against adenovirus, Haemophilus influenzae, pneumococcus, and Neisseria meningitidis is also effective.[27] ... Adenoviruses are the most common cause of viral conjunctivitis (adenoviral keratoconjunctivitis).[14] Herpetic ...
The current types of vaccines which are in research are particle-based vaccines, attenuated vaccines, protein subunit vaccines ... A respiratory syncytial virus vaccine (RSV vaccine) is a vaccine which prevents infection by respiratory syncytial virus. No ... or vector-based vaccines.[3] References[edit]. *^ a b Dudas, RA; Karron, RA (July 1998). "Respiratory syncytial virus vaccines" ... A 2019 paper claimed that research toward developing a vaccine has advanced greatly over the past 10 years.[2] The same study ...
... adenovirus-2, leptospirosis, bordatella, canine parainfluenza virus, and Lyme disease. ... There are many different types of vaccines.[2] One common type of vaccine is a "live vaccine." This type of vaccine contains a ... Additional components in vaccines[change , change source]. Vaccines often contain other things besides the active vaccine (the ... Nowadays, vaccines are given to people of all ages.[20][21]. *Combinations of vaccines are becoming more common. Vaccines ...
Vaxjo: Comprehensive vaccine adjuvant database.. References[edit]. *^ "Guideline on Adjuvants in Vaccines for Human Use" (PDF) ... Baylor NW, Egan W, Richman P (May 2002). "Aluminum salts in vaccines--US perspective". Vaccine. 20 Suppl 3 (Suppl 3): S18-23. ... In the early days of vaccine manufacture, significant variations in the efficacy of different batches of the same vaccine were ... Clements CJ, Griffiths E (May 2002). "The global impact of vaccines containing aluminium adjuvants". Vaccine. 20 Suppl 3 ( ): ...
2014). "Bovine rotavirus pentavalent vaccine development in India". Vaccine. 32 (11): A124-A128. doi:10.1016/j.vaccine.2014.03. ... live attenuated Rotavirus vaccine (ROTASIIL®)". Vaccine. 35 (22): 2962-2969. doi:10.1016/j.vaccine.2017.04.025. PMID 28434688. ... The vaccines are safe.[2] This includes their use in people with HIV/AIDS.[2] An earlier vaccine that is no longer used was ... The vaccine contains a G1P[8] human rotavirus strain.[23] Lanzhou lamb[edit]. Lanzhou lamb rotavirus vaccine was licensed for ...
Adenovirus vaccines[change , change source]. The adenovirus is the virus that causes the common cold.[1] It does not harm the ... The Chinese company CanSino Biologics is making a viral vector vaccine. This vaccine uses an adenovirus that has the spike ... It is an inactivated virus vaccine.[33] This vaccine started phase III trials in the middle of July 2020. This vaccine does not ... Moderna vaccine[change , change source]. In mid-May 2020, a company called Moderna said they tested their mRNA vaccine in forty ...
එන්නතක් යනු (ඉංග්‍රීසි: Vaccine) එක්තරා රෝගයක් සදහා ප්‍රතිශක්තිකරණය වැඩි දියුණු කර ගැනීම පිණිස ඇති නිෂ්පාදනයකි. මෙම වැක්සීන් යන ... Jonas Salk in 1955 holds two bottles of a culture used to grow polio vaccines. ...
Vaccine-naive. References[edit]. *^ a b c d Schmaljohn, C. S. (2012). "Vaccines for hantaviruses: Progress and issues". Expert ... The pharmaceutical trade name for the vaccine is Hantavax.[2][3] As of 2013 no hantavirus vaccine have been approved for use in ... Hantavirus vaccine is a vaccine that protects in humans against hantavirus infections causing Hantavirus hemorrhagic fever with ... They include a recombinant vaccine and vaccines derived from HTNV and PUUV viruses. However, their prospects are unclear.[1] ...
Inactivated vaccine. *Live vector vaccine *Attenuated vaccine. *Heterologous vaccine. *Subunit/component / Peptide / Virus-like ...
... vaccine) හෝ විශේෂිත ප්‍රතිවෛරස ප්‍රතිකාරයක් (antiviral treatment) නොමැත. කළහැක්කේ රෝග ලක්ෂණ පාලනය (treatment of symptoms), ... Adenovirus Adenovirus infection. RNA virus. Rotavirus. Norovirus. Astrovirus. Coronavirus. Hepatitis. DNA virus. HBV (B). RNA ...
"Human Vaccines. 7. 7: 734-748. doi:10.4161/hv.7.7.15511. PMID 21734466. Nakuha noong 10 May 2012.. Unknown parameter ,month=. ... Gastroenteritis viruses: A = rotavirus, B = adenovirus, C = Norovirus and D = Astrovirus. The virus particles are shown at the ... "Human Vaccines. 6 (7): 532-542. PMID 20622508. Nakuha noong 10 May 2012.. Unknown parameter ,month=. ignored (tulong)CS1 maint ... "Reduction in rotavirus after vaccine introduction-United States, 2000-2009". MMWR Morb. Mortal. Wkly. Rep. 58 (41): 1146-9. ...
... adenovirus, and cytomegalovirus.[5] Some people with aphthous stomatitis may show herpes virus within the epithelium of the ... polio virus vaccine and prostaglandin E2.[2] ...
en svækket adenovirus, en teknik der også testes for genterapi, se billedet og jvf. Vektor-vaccine. ... DNA-vaccine kaldes også DNA-baseret vaccine eller gen-baseret vaccine og er en nukleinsyre-baseret vaccine, en type vaccine, ... DNA Immunization for HIV Vaccine Development. Vaccines 2014 *^ Vaccine innovation spurred by the long wait for an Ebola virus ... Engineering DNA vaccines against infectious diseases. Acta Biomaterialia 2018 *^ a b c "DNA vaccines". World Health ...
Classes: Inactivated vaccine · Live vector vaccine (Attenuated vaccine, Heterologous vaccine) · Toxoid · Subunit/component / ... Adenovirus · Tick-borne encephalitis · Japanese encephalitis# · Flu# (LAIV, H1N1 (Pandemrix)) · Hepatitis A# · Hepatitis B# · ... Global: GAVI Alliance · Policy · Schedule · Vaccine injury. USA: ACIP · VAERS · VSD · Vaccine court · Vaccines for Children ... TA-CD • TA-NIC · NicVAX · Cancer vaccines (ALVAC-CEA vaccine, Hepatitis B# · HPV (Gardasil, Cervarix)) ...
... have been suggested acting as antigens for improving of vaccines. For pigs vaccine; inactivated live, monovalent combined, most ... which only work with a helper virus such as adenovirus. Other viruses that can infect without helper viruses are called as ... Currently there is no vaccine to prevent infection by all parvoviruses, but recently the virus's capsid proteins, which are ...
Main article: Hepatitis C vaccine. Unlike hepatitis A and B, there is currently no vaccine to prevent hepatitis C infection.[60 ... Adenovirus Adenovirus infection. RNA virus. Rotavirus. Norovirus. Astrovirus. Coronavirus. Hepatitis. DNA virus. HBV (B). RNA ... "A new insight into hepatitis C vaccine development". J. Biomed. Biotechnol. 2010: 1-12. doi:10.1155/2010/548280. PMC 2896694 ...
Vaccines ,state=expanded}}. ഈ ഫലകത്തിന്റെ ഉള്ളടക്കത്തെ എപ്പോഴും മുഴുവനായി കാണിക്കാൻ ഇങ്ങനെ ഉപയോഗിക്കുക.. {{Vaccines ,state= ... Vaccines ,state=collapsed}}. ഈ ഫലകത്തിന്റെ ഉള്ളടക്കത്തെ മറച്ചുവെച്ച് പ്രധാന തലക്കെട്ട് മാത്രമായി കാണിക്കാൻ ഇങ്ങനെ ഉപയോഗിക്കുക. ... "https://ml.wikipedia.org/w/index.php?title=ഫലകം:Vaccines&oldid=2398857" എന്ന താളിൽനിന്നു ശേഖരിച്ചത് ...
Mange lidt forskellige adenovirus kan forårsage forkølelse.[10] Nukleinsyre-vacciner[redigér , redigér wikikode]. RNA-vaccine[ ... Svækket vaccine[redigér , redigér wikikode]. En svækket vaccine eller en levende svækket vaccine er en vaccine, der er skabt ... Subunit-vaccine[redigér , redigér wikikode]. En subunit-vaccine er en vaccine med et fragment eller en en del af en patogen ... Uddybende artikel: RNA-vaccine. I stedet for selve antigenet som i den traditionelle vaccine, vaccineres der med en RNA-vaccine ...
Gene therapy using an adenovirus vector.. Three forms of human enhancement currently exist: reproductive, physical, and mental ...
... is a combination vaccine whose generic name is diphtheria and tetanus toxoids and acellular pertussis ... This vaccine article is a stub. You can help Wikipedia by expanding it.. *v ... "DTaP-IPV-HepB vaccine" - news · newspapers · books · scholar · JSTOR (June 2018) (Learn how and when to remove this template ... "Licensure of a diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine and guidance ...
Offit, Paul A. (2005). The Cutter Incident: How America's First Polio Vaccine Led to the Growing Vaccine Crisis. Yale ... He was opposed by vaccine critics, many of whom believe vaccines cause autism, a belief that has been rejected by major medical ... doi:10.1016/j.vaccine.2014.04.085. PMID 24814559.. *^ a b "Author royalties from autism book donated to autism research" (Press ... Sabin Gold Medal from the Sabin Vaccine Institute in Washington, DC for his work on the oral rotavirus vaccine and his ...
Other vaccine trials continue worldwide including a mosaic vaccine using an adenovirus 26 vector[9] as well as a newer ... HIV vaccine[edit]. Main article: HIV vaccine. An HIV vaccine is a vaccine that would be given to a person who does not have HIV ... Only a vaccine is thought to be able to halt the pandemic. This is because a vaccine would cost less, thus being affordable for ... In 2003 a clinical trial in Thailand tested an HIV vaccine called RV 144. In 2009, the researchers reported that this vaccine ...
... for the inactivated fowl vaccine, QI01CL01 (WHO) for the inactivated turkey combination vaccine).[45] ... Adenovirus Adenovirus infection. RNA virus. Rotavirus. Norovirus. Astrovirus. Coronavirus. Hepatitis. DNA virus. HBV (B). RNA ... Vaccines for poultry have been formulated against several of the avian H5N1 influenza varieties. Control measures for HPAI ... Currently no vaccine exists, but the use of influenza antiviral drugs known as neuraminidase inhibitors in cases of early ...
"A treatment for and vaccine against the deadly Hendra and Nipah viruses"। Antiviral Research (ইংরেজি ভাষায়)। 100 (1): 8-13। ... DNA virus: Adenovirus (Adenovirus infection). RNA virus:Rotavirus · Norovirus · Astrovirus · Coronavirus. Hepatitis ... "A treatment for and vaccine against the deadly Hendra and Nipah viruses"। Antiviral Research (ইংরেজি ভাষায়)। 100 (1): 8-13। ... "A Hendra Virus G Glycoprotein Subunit Vaccine Protects African Green Monkeys from Nipah Virus Challenge"। Science ...
Adenovirus vaccine. Adenovirus vaccine is only available for United States military personnel. There is currently no adenovirus ... Adenovirus vaccine can prevent infection with some types of adenovirus.. Adenoviruses can cause illness that is usually mild, ... Adenovirus vaccine contains live adenovirus Type 4 and Type 7. It will prevent most illness caused by these two virus types. ... Vaccine Information Statement. Adenovirus Vaccine (1/8/20). Department of Health and Human Services. Centers for Disease ...
Proper Name: Adenovirus Type 4 and Type 7 Vaccine, Live, Oral. Trade Name: None. Manufacturer: Barr Labs, Inc.. Indication: ... October 20, 2014 Approval Letter - Adenovirus Type 4 and Type 7 Vaccine, Live, Oral. To revise the package insert to remove ... Package Insert - Adenovirus Type 4 and Type 7 Vaccine, Live, Oral. (PDF - 129KB) ... Approval History, Letters, Reviews and Related Documents - Adenovirus Type 4 and Type 7 Vaccine, Live, Oral (ZIP - 1.5MB) ...
... that recognized a component of the vaccine (adenovirus serotype 5 [Ad5]). ... Moreover, subsequent analyses indicated that the vaccine made some individuals more susceptible to HIV, in particular ... A clinical trial testing a candidate HIV vaccine known as the STEP study was halted in September 2007 after interim analysis ... Tags: Adenovirus, Antibodies, Cancer, Cell, Clinical Trial, HIV, HIV/AIDS, HIV-1, Immune System, Research, Vaccine ...
COVID-19 Vaccine (Adenovirus Vector) - Last updated on April 13, 2021. All rights owned and reserved by Memorial Sloan ... This vaccine may not work as well.. *Rarely, cases of Bells palsy happened in studies. It is not known if this vaccine may be ... AstraZeneca COVID-19 Vaccine; Covishield; Janssen COVID-19 Vaccine. What is this drug used for?. *It is used to prevent COVID- ... Like all vaccines, this vaccine may not fully protect all people who get it. If you have questions, talk with the doctor. ...
Adenovirus type 4 and type 7 live vaccine is used to prevent febrile (with fever) acute respiratory disease (ARD) caused by ... This vaccine is to be administered only by or under the supervision of your doctor or other health care professional. ... This vaccine is given to military personnels 17 to 50 years of age. ... adenovirus type 4 and type 7. It works by causing your body to produce its own protection (antibodies) against the virus. ...
Replication defective adenoviruses have emerged as promising vectors for delivery of vaccine antigens. The development of new ... This thesis describes the construction and optimisation of ChAdOX1, a new vector based on chimpanzee adenovirus Y2S, which has ... Aft intramuscular administration, HAdV-S (Human adenovirus C) based vectors elicited superior transgene product specific T cell ... and antibody responses compared to a selection of chimpanzee adenovirus vectors (from Human adenovirus EJ including ChAdOX1. ...
Introduction Oral vaccines delivered as tablets offer a number of advantages over traditional parenteral-based vaccines ... N = 10 for Ad vaccine groups. N = 4 for TIV vaccine. Ad adenovirus, CI confidence interval, ELISA enzyme-linked immunosorbent ... The various vaccine combinations were tested by blending monovalent recombinant adenovirus vaccines, each expressing ... We have been developing an oral-based adenovirus platform for vaccine delivery. The vaccine platform consists of a replication- ...
Upon subcutaneous vaccination with the adenovirus-PSA prostate cancer vaccine, the adenovirus infects cells and expresses PSA. ... replication-deficient type 5 adenovirus carrying the human prostate-specific antigen (PSA), with potential immunostimulating ... A cancer vaccine composed of a genetically engineered, ... adenovirus-PSA prostate cancer vaccine A cancer vaccine ... Upon subcutaneous vaccination with the adenovirus-PSA prostate cancer vaccine, the adenovirus infects cells and expresses PSA. ...
The resultant recombinant adenovirus vectored vaccine will be produced in a HEK293 cell culture system rather than SPF eggs. ... Adenovirus (Ads) vectors are extensively used for recombinant vaccines with many advantages, including cost-effective ... A secondary aim of this project is to transfer technical capacity for recombinant adenovirus vaccine development and production ... Current vaccines against ND are either live or inactivated ND viruses. Inactivated ND vaccines provide incomplete protection, ...
But how do they work? Immunologist Matt Koci brings you up to speed on mRNA and adenovirus vaccines. ... what vaccines might be released next? Ive also heard some talk about adenovirus vaccines. What are adenovirus vaccines? Are ... Of the six vaccines backed by Operation Warp Speed, the adenovirus vectored vaccines are the only other vaccines, besides mRNA ... Like the mRNA vaccines, this type of vaccine has been around as an idea for a while, and there are several adenovirus-vectored ...
... we aim to present and discuss the progress and prospects in the field of vaccine research towards SARS-CoV-2 using adenovirus ( ... Researchers and clinicians from all over the world are advancing the development of a vaccine against novel human SARS-CoV-2 ... Nevertheless, currently there are no licensed vaccines for the novel coronaviruses. ... Keywords: SARS-CoV-2; vaccine; adjuvant; adenovirus; COVID-19 SARS-CoV-2; vaccine; adjuvant; adenovirus; COVID-19 ...
... teamed up with the University of Oxfords Jenner Institute to develop more cost-effective manufacturing processes for vaccines ... Adenovirus is a popular viral vector for vaccine development. It has been used in vaccine candidates against tuberculosis, HIV ... The partnership aims to improve the production of vaccines that use adenovirus as vectors. With 30 years experience in viral ... Merck KGaA hooks up with Jenner Institute on adenovirus-vector vaccine production ...
Other Name: Adenovirus Serotype 4-vectored H5N1 Influenza Vaccine. Biological: Sanofi Pasteur Influenza Virus Vaccine, H5N1 ... Other Name: Adenovirus Serotype 4-vectored H5N1 Influenza Vaccine. Biological: Sanofi Pasteur Influenza Virus Vaccine, H5N1 ... Other Name: Adenovirus Serotype 4-vectored H5N1 Influenza Vaccine. Biological: Sanofi Pasteur Influenza Virus Vaccine, H5N1 ... Other Name: Adenovirus Serotype 4-vectored H5N1 Influenza Vaccine. Biological: Sanofi Pasteur Influenza Virus Vaccine, H5N1 ...
Live attenuated vaccine within 30 days prior to first injection. *Any vaccine that is not a live attenuated vaccine within 14 ... Biological: Ad5.ENVA.48 HIV-1 vaccine Recombinant adenovirus serotype 5 HIV-1 vaccine ... Biological: Ad5.ENVA.48 HIV-1 vaccine Recombinant adenovirus serotype 5 HIV-1 vaccine ... Biological: Ad5.ENVA.48 HIV-1 vaccine Recombinant adenovirus serotype 5 HIV-1 vaccine ...
FRIDAY, July 24, 2020 (HealthDay News) - A chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19) expressing the severe acute ... Several authors are named as inventors on a patent relating to ChAdOx1-vectored vaccines and this specific vaccine.. . ... randomized trial of a ChAdOx1 nCoV-19 compared to a meningococcal conjugate vaccine (MenACWY) as control. Healthy adults aged ...
Live adenovirus type 4 vaccine oral dosage form. Known as: adenovirus, type 4 ... Concurrent administration of live adenovirus, type 4 and live Poliovirus, type 1 vaccines. ... We have previously reported 50% human infectious doses (HID50) of adenovirus, type 4 (adeno 4), and Coxsackie virus A, type 21 ...
The development of safe and effective vaccine is urgent need. In this study, we constructed a novel simian adenovirus type 23 ... the immune response and protective efficacy of vaccine were extensively evaluated. The data suggested that Sad23L-prM-E vaccine ... By vaccinating the common marmosets with prime immunization of vaccine, and upon challenge with a high dose of ZIKV to the ... could protect marmosets against a high dose of ZIKV challenge, which provided a promising vaccine for preventing ZIKV infection ...
Received HIV vaccine(s) in a prior HIV vaccine trial. Participants who received a control/placebo in an HIV vaccine trial are ... Participants will be randomly assigned to receive either the rAd26 vaccine or a placebo vaccine. All vaccines will be injected ... Evaluating the Safety and Immune Response of an Adenovirus-Based HIV Vaccine in HIV-Uninfected Adults. The safety and ... Many HIV preventive vaccines that are in development use a recombinant adenovirus serotype 5 (rAd5) vector as a way of ...
Here, we report the development of a new candidate rabies vaccine, designed to enable low-cost single-dose pre-exposure human ... ChAdOx2 RabG is based upon a simian adenovirus-vectored candidate previously shown to achieve protection after a single dose in ... Although it is eminently preventable, with highly efficacious vaccines available for both humans and animals, it still causes ... the second human disease for which an efficacious vaccine was developed, by Pasteur in 1885. ...
The 2011 implementation of a replacement vaccine led to dramatic and sustained decreases in ARD cases, supporting continuation ... The 1999 cessation of vaccination against adenovirus types 4 and 7 among US Army trainees resulted in reemergence of acute ... During the 1999-2010 lapse in adenovirus vaccine coverage, 8 adenovirus-infected service members died (13). Estimates showed ... Kuschner RA, Russell KL, Abuja M, Bauer KM, Faix DJ, Hait H, et al.; Adenovirus Vaccine Efficacy Trial Consortium. A phase 3, ...
Upon intradermal administration, adenovirus encoding tyrosinase/MART-1/MAGEA6-transduced autologous DC vaccine may stimulate a ... A cell-based cancer vaccine composed of autologous dendritic cells (DCs) transduced with a recombinant adenoviral vector ... adenovirus encoding tyrosinase, MART-1/MAGE-A6-transduced autologous dendritic cell vaccine A cell-based cancer vaccine ... Upon intradermal administration, adenovirus encoding tyrosinase/MART-1/MAGEA6-transduced autologous DC vaccine may stimulate a ...
Adenovirus vectored vaccines, any coronavirus or SARS vaccines). *Administration of immunoglobulins and/or any blood products ... Phase III Trial of A COVID-19 Vaccine of Adenovirus Vector in Adults 18 Years Old and Above. The safety and scientific validity ... vaccine. Ad5. Safety. Immunogencity. efficacy. adaptive design. SARS-CoV-2. Adenovirus Vector. ... Biological: Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) Biological: Placebo Phase 3 ...
Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS- ... A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1- ... Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS- ... "Single Intranasal Immunization With Chimpanzee Adenovirus-based Vaccine Induces Sustained and Protective Immunity Against MERS- ...
Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein. ... Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein ... Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein ... Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein ...
An adenovirus-based TB vaccine elicits T cell immunogenicity despite preexisting anti-AdHu5 immunity in people. ... An adenovirus-based TB vaccine elicits T cell immunogenicity despite preexisting anti-AdHu5 immunity in people. ... AdHu5Ag85A is a recombinant human type 5 adenovirus (AdHu5)-based TB vaccine with demonstrated efficacy in a number of animal ... A Human Type 5 Adenovirus-Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti- ...
Quantifying Adenovirus-Neutralizing Antibodies by Luciferase Transgene Detection: Addressing Preexisting Immunity to Vaccine ... Quantifying Adenovirus-Neutralizing Antibodies by Luciferase Transgene Detection: Addressing Preexisting Immunity to Vaccine ... Quantifying Adenovirus-Neutralizing Antibodies by Luciferase Transgene Detection: Addressing Preexisting Immunity to Vaccine ... Quantifying Adenovirus-Neutralizing Antibodies by Luciferase Transgene Detection: Addressing Preexisting Immunity to Vaccine ...
Accelerated heterologous adenovirus prime-boost SIV vaccine in neonatal rhesus monkeys. J Virol. 2012 Aug; 86(15):7829-35. ...
... preventive HIV vaccines for use throughout the world. ... The International AIDS Vaccine Initiative (IAVI) is a global ... Title: Broad HIV epitope specificity and viral inhibition induced by multigenic HIV 1 adenovirus subtype 35 vector vaccine in ... Broad HIV epitope specificity and viral inhibition induced by multigenic HIV 1 adenovirus subtype 35 vector vaccine in healthy ... Broad HIV epitope specificity and viral inhibition induced by multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy ...
... prostate cancer vaccines to date demonstrate modest efficacy and low immunogenicity. The goal of the present pre-clinical study ... More News: Adenoviruses , Allergy & Immunology , Cancer , Cancer & Oncology , Cancer Vaccines , Epithelial Cancer , ... Immunogenicity and efficacy of the novel cancer vaccine based on simian adenovirus and MVA vectors alone and in combination ... The simian adenovirus, ChAdOx1, and modified vaccinia Ankara virus, MVA, encoding a prostate cancer-associated antigen, the six ...
2009) Enhanced Protection against Ebola Virus Mediated by an Improved Adenovirus-Based Vaccine. PLoS ONE 4(4): e5308. doi: ... replication defective adenovirus-based Ebola vaccine is being studied in a phase I clinical trial. Another Ebola vaccine, based ... Enhanced Protection against Ebola Virus Mediated by an Improved Adenovirus-Based Vaccine. ... In this report, we modified the common recombinant adenovirus serotype 5-based Ebola vaccine expressing the wild-type ZEBOV ...
  • Replication defective adenoviruses have emerged as promising vectors for delivery of vaccine antigens. (bl.uk)
  • The development of new vaccine vectors has recently focused on serotypes t, which the human population is less exposed in order to circumvent pre-existing anti vector immunity. (bl.uk)
  • Aft intramuscular administration, HAdV-S (Human adenovirus C) based vectors elicited superior transgene product specific T cell and antibody responses compared to a selection of chimpanzee adenovirus vectors (from Human adenovirus EJ including ChAdOX1. (bl.uk)
  • We have been evaluating an oral vaccine platform based on recombinant adenoviral vectors for the purpose of creating a prophylactic vaccine to prevent influenza, and have demonstrated vaccine efficacy in animal models and substantial immunogenicity in humans. (springer.com)
  • We demonstrated minimal interference between the various vaccine vectors when used in combination and that the oral quadrivalent vaccine compared favorably to an approved trivalent inactivated vaccine. (springer.com)
  • Adenovirus (Ads) vectors are extensively used for recombinant vaccines with many advantages, including cost-effective manufacturing, long-term stability, high efficacy, and a well-established safety profile in humans and animals. (idrc.ca)
  • The partnership aims to improve the production of vaccines that use adenovirus as vectors. (fiercepharma.com)
  • Because of their efficient gene delivery feature, adenovirus vectors also hold promise outside of infectious diseases and in the hot area of gene- and cell-based therapies for cancer and genetic and regenerative diseases. (fiercepharma.com)
  • Recombinant adenovirus serotype vectors have been shown to elicit just such a response. (clinicaltrials.gov)
  • Recombinant adenoviruses (rAd) based predominantly on serotype 5 (Ad5) and Ad2 are under investigation as vectors for gene delivery and vaccination in humans. (asm.org)
  • Recent investigations in rodents and nonhuman primates have confirmed that Ad vectors are powerful vaccine delivery vehicles ( 1 , 19 , 21 ). (asm.org)
  • Here, the breadth and specificity of T-cell responses induced following vaccination with replication-defective adenovirus serotype 35 (Ad35) vectors containing a fusion protein of Gag, reverse transcriptase (RT), Integrase (Int) and Nef (Ad35-GRIN) and Env (Ad35-ENV), derived from HIV-1 subtype A isolates, was assessed in 25 individuals. (iavi.org)
  • These include virus-like particle preparations ( 3 - 6 ), vesicular stomatitis virus ( 7 - 11 ), human parainfluenza virus type 3 ( 12 - 14 ), and replication-deficient human adenovirus serotype 5 (AdHu5) vectors ( 15 - 18 ) expressing an EBOV gene(s). (asm.org)
  • However, replication-deficient AdHu5-based vectors are an attractive vaccine platform, as they induce a strong innate and adaptive immune response ( 19 ). (asm.org)
  • Adenoviruses are safe and highly immunogenic vaccine vectors capable of inducing lasting humoral and cellular immune responses. (unl.edu)
  • Adenoviral vectors have shown significant promise as vaccine delivery vectors due to their ability to elicit both innate and adaptive immune responses. (prolekare.cz)
  • In this study, we evaluated the role of α-defensin 5 (HD5) in modulating adenovirus vaccine immunogenicity using various serotype adenovirus vectors in mice. (prolekare.cz)
  • These data demonstrate that HD5 differentially modulates adenovirus vaccine delivery vectors in a species-specific manner in vivo . (prolekare.cz)
  • Replication-deficient chimpanzee adenovirus (ChAd) vectors are an ideal platform for development of a human RVF vaccine, given the low prevalence of neutralizing antibodies against them in the human population, and their excellent safety and immunogenicity profile in human clinical trials of vaccines against a wide range of pathogens. (biomedcentral.com)
  • Together the results support further development of RVF vaccines based on replication-deficient adenovirus vectors, with ChAdOx1-GnGc being a potential candidate for use in future human clinical trials. (biomedcentral.com)
  • Thus, development of Gn and Gc-based vaccines utilizing vectors with an established human safety profile could be a promising strategy for a future human RVF vaccine. (biomedcentral.com)
  • The chimpanzee adenovirus, PanAd3-RSV, and modified vaccinia virus Ankara, MVA-RSV, are replication-defective viral vectors encoding the RSV fusion (F), nucleocapsid (N), and matrix (M2-1) proteins for the induction of humoral and cellular responses. (ox.ac.uk)
  • Novel adenoviral vaccine vectors from strains with lower seroprevalence worldwide are being developed that can evade pre-existing immunity. (biomedcentral.com)
  • Adenovirus serotype 5 (Ad5) vaccine vectors elicit mixed responses-they induce protective CD8 + T cells, but these cells may be partially exhausted. (sciencemag.org)
  • However, both the chimpanzee adenovirus (ChAd) and modified vaccinia virus Ankara (MVA) vectors,2 which were developed by the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases in collaboration with Okairos, had already been manufactured to clinical grade at the time of the acceleration of the EVD outbreak in early August 2014. (exploredoc.com)
  • Adenoviruses are often used as vectors for numerous infectious agents. (news24.com)
  • The trial randomized 400 participants into eight groups of 50, with each receiving different prime-boost recipes drawn from four possible ingredients: adenovirus serotype 26 (Ad26) vectors, modified Vaccinia Ankara strain (MVA) vectors and high or low dose trimeric clade C gp140 protein in alum adjuvant. (typepad.com)
  • This proposal wil build on our experience developing chimeric recombinant proteins and recombinant adenovirus vectors to develop a coadministration vaccination regimen that combines these two vaccine platforms. (grantome.com)
  • We will modify existing adenovirus vectors that express a Plasmodium multi-stage protective antigen as a transgene by insertion of a promiscuous T cell epitope within the capsid structure. (grantome.com)
  • Characterize and compare the effect of the insertion of T cell epitopes within the capsid on the immunogenicity of recombinant adenovirus vectors. (grantome.com)
  • We will use adenovirus serotype 5 (Ad5) and the chimeric Ad5/3 vectors for capsid modification. (grantome.com)
  • We hypothesized that MAIT cells may have inherent adjuvant activity in vaccine platforms that use replication-incompetent adenovirus vectors. (jenner.ac.uk)
  • Thus, MAIT cells contribute to the immunogenicity of adenovirus vectors, with implications for vaccine design. (jenner.ac.uk)
  • Stabilization of virus protein structure and nucleic acid integrity is challenging yet essential to preserve the transcriptional competence of live recombinant viral vaccine vectors in the absence of a cold chain. (elsevier.com)
  • This study demonstrates an important technical advance for viral vaccine vectors progressing to the clinic and provides insights into the mechanism of CD8 + T-cell priming by live rAdHu5 MAs. (elsevier.com)
  • Adenoviruses are considered as excellent vectors for delivering target antigens to mammalian hosts because of their capability to induce both innate and adaptive immune system. (avac.org)
  • 12, 13 Since steroids are anti-inflammatory, 14 we sought the possibility that the high content of corticosteroids in the adrenal gland may prevent the immune reaction to adenovirus injection and make it possible to use these vectors for gene therapy in the adrenal. (nature.com)
  • Adenovirus vectors for cancer gene therapy could be significantly improved if their tropism were restricted to tumor cells. (ebscohost.com)
  • It should not be confused with the strategy of using adenovirus as a viral vector to develop vaccines for other pathogens, or as a general gene carrier. (wikipedia.org)
  • This thesis describes the construction and optimisation of ChAdOX1, a new vector based on chimpanzee adenovirus Y2S, which has recently been manufactured to clinical grade for a Phase 1 human trial. (bl.uk)
  • Adenovirus is a popular viral vector for vaccine development. (fiercepharma.com)
  • Many HIV preventive vaccines that are in development use a recombinant adenovirus serotype 5 (rAd5) vector as a way of delivering the vaccine into cells. (clinicaltrials.gov)
  • However, the majority of people, particularly in the developing world, have immunity against the Ad5 vector, which means the vaccine will not be effective at preventing HIV infection. (clinicaltrials.gov)
  • This study will use a rAd26 vector as part of a HIV vaccine, as research has shown that relatively few people have immunity against this vector. (clinicaltrials.gov)
  • The purpose of this study is to evaluate the safety and immunogenicity of a rAd26 vector preventive HIV-1 vaccine. (clinicaltrials.gov)
  • A cell-based cancer vaccine composed of autologous dendritic cells (DCs) transduced with a recombinant adenoviral vector encoding three full-length human melanoma associated antigens (MAAs), tyrosinase, melan-A (MART-1) and the melanoma antigen A6 (MAGEA6), with potential antineoplastic activity. (cancer.gov)
  • This study is a global multicenter, randomized, double-blind, placebo -controlled, adaptive designed phase Ⅲ clinical trial, in order to evaluate the efficacy, safety and immunogenicity of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) in adults 18 years old and above. (clinicaltrials.gov)
  • There's an aspect of this vector I preferred over at least one of the other vector vaccines. (flutrackers.com)
  • Adenovirus-vector vaccines are supposed to be engineered so they can?t replicate. (flutrackers.com)
  • Preexisting immunity to adenovirus serotype 5 (Ad5) has been shown to suppress the immunogenicity of recombinant Ad5 (rAd5) vector-based vaccines for human immunodeficiency virus type 1 (HIV-1) in both preclinical studies and clinical trials. (asm.org)
  • Recombinant adenovirus serotype 5 (rAd5) vector-based vaccines have been shown to elicit high-frequency, protective immune responses in a variety of animal models ( 22 , 23 , 26 , 27 ). (asm.org)
  • However, the high prevalence of preexisting anti-Ad5 immunity in human populations may limit the immunogenicity and clinical utility of rAd5 vector-based vaccines, particularly in the developing world ( 12 , 29 , 30 ). (asm.org)
  • Efficacy of a T Cell-Biased Adenovirus Vector as a Zika Virus Vaccine" by Brianna L. Bullard, Brigette N. Corder et al. (unl.edu)
  • Here, in BALB/c mice, we evaluated the immunogenicity and efficacy of a replication-deficient chimpanzee adenovirus vector, ChAdOx1, encoding the RVF virus envelope glycoproteins, Gn and Gc, which are targets of virus neutralizing antibodies. (biomedcentral.com)
  • The ChAdOx1-GnGc vaccine was assessed in comparison to a replication-deficient human adenovirus type 5 vector encoding Gn and Gc (HAdV5-GnGc), a strategy previously shown to confer protective immunity against RVF in mice. (biomedcentral.com)
  • Human adenovirus serotype 5 is a potent vaccine vector, but its use has been hampered by high seroprevalence amongst people in sub-Sahara Africa. (biomedcentral.com)
  • Here we describe the development of a simian Ad24 (sAd24)-based vaccine vector. (biomedcentral.com)
  • These data suggest that sAd24 is promising for further studies as a candidate vaccine vector. (biomedcentral.com)
  • Maybe the happy medium here are the adenovirus vector vaccines. (medscape.com)
  • Vector vaccines use an existing virus, modified to express a SARS-CoV-2 protein as a Trojan horse, to rev up the immune response. (medscape.com)
  • These data suggest that targeting this inhibitory pathway may enhance protection of viral vector-based vaccines. (sciencemag.org)
  • The use of the monovalent formulation halves the manufacturing challenge, as compared with use of the bivalent vaccine, which includes a second vector encoding the Sudan strain glycoprotein16 with only 60% identity to the Guinea outbreak strain. (exploredoc.com)
  • FIG. 1 shows diagrammatically a construct of a defective recombinant adenoviral vector employing an insertion sequence coding for an interleukin (IL-2, IL-4 and the like).In this figure, "leaders" corresponds to a tripartite leader, "Del" corresponds to a "deletion" and Ad dl 324 corresponds to an adenovirus provided with the above-mention "deletions. (google.com)
  • We developed a novel vaccination regimen involving replication-defective and serologically distinct chimpanzee adenovirus (ChAd3, ChAd63) vector priming followed by modified vaccinia Ankara (MVA) boosts, for simultaneous delivery of HCV non-structural (NSmut) and HIV-1 conserved (HIVconsv) region immunogens. (frontiersin.org)
  • The only example to date occurred around the turn of the millennium with Merck's adenovirus serotype 5 (Ad5) vector, which showed some evidence of promise in macaque models but was ultimately discontinued after being associated with an enhanced-rather than reduced-risk of HIV acquisition in the STEP and Phambili trials. (typepad.com)
  • Preclinical studies of viral vector-based HIV-1 vaccine candidates have previously shown partial protection against neutralization-resistant virus challenges in rhesus monkeys. (jpt.com)
  • In this study, we evaluated the protective efficacy of adenovirus serotype 26 (Ad26) vector priming followed by purified envelope (Env) glycoprotein boosting. (jpt.com)
  • Dendritic cell based PSMA immunotherapy for prostate cancer using a CD40-targeted adenovirus vector. (nih.gov)
  • Our goal was to improve upon cancer vaccination with tumor antigens by delivering PSMA via a CD40-targeted adenovirus vector directly to DCs as an efficient means for activation and antigen presentation to T-cells. (nih.gov)
  • The high levels of preexisting immunity against Adenovirus type 5 (Ad5) have deemed Ad5 unusable for translation as a human vaccine vector. (elsevier.com)
  • However, the species D Ad vaccine vector, Ad48, induced significantly greater protection as compared with Ad5 when delivered mucosally via the intranasal route in CD46 transgenic mice. (elsevier.com)
  • This familiarity makes re-vaccination less effective as immune responsive cells disable the adenovirus vector before it can convey genetic instructions to the cells. (immunization.news)
  • The booster shots for adenovirus-vector vaccines are not nearly as effective as the original vaccine and contribute to the mutation of live viruses that cause symptoms of the common cold in healthy people and more serious health issues for people with weak immune systems . (immunization.news)
  • If immune responsive cells recognize the vector, the intended process of encoding spike proteins is thwarted, rendering the vaccine protocol ineffective and making the vaccine recipient more susceptible to colds and other coronavirus infections in the future. (immunization.news)
  • DNA and recombinant vector vaccines are two additional types of vaccine that are still in the experimental stages of development. (medicalnewstoday.com)
  • People with weakened immune systems, or existing lung or heart disease, are at higher risk of developing severe illness from an adenovirus infection. (cdc.gov)
  • Infection with adenovirus can also rarely lead to more serious problems, such as severe pneumonia or neurologic disease (conditions that affect the brain and spinal cord), and even death. (cdc.gov)
  • It may also be recommended for other military personnel at high risk for adenovirus infection. (cdc.gov)
  • An adenovirus vaccine is a vaccine against adenovirus infection. (wikipedia.org)
  • A vaccine that will prevent HIV infection will elicit a strong immune response from both CD4 and CD8 cells. (clinicaltrials.gov)
  • Another Ebola vaccine, based on an attenuated vesicular stomatitis virus has shown efficacy in post-exposure treatment of nonhuman primates to Ebola infection. (utexas.edu)
  • In recent years, several vaccine platform candidates have proven efficacious against lethal EBOV infection in several animal models. (asm.org)
  • Currently, there are no approved vaccines available to protect against infection. (unl.edu)
  • α-defensins are effector molecules of the innate immune response and have been shown to modulate natural infection with adenoviruses, but the majority of α-defensin-adenovirus interactions studied to date have only been analyzed in vitro . (prolekare.cz)
  • With one dose, these vaccines confer long-lasting protection from Ad4 and Ad7 infection with great efficacy and exemplary safety ( 1 ). (asm.org)
  • Both vaccines prevent persistent HPV infection and cervical disease induced by the HPV types included in the vaccine ( 2 ). (asm.org)
  • Healthy adults aged 18 years or older, who were HIV-negative and previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-free, were eligible to participate and were randomly assigned to receive the vaccine at a dose of 1 × 10 viral particles per mL or 5 × 10 viral particles per mL, or placebo. (physiciansweekly.com)
  • In vitro hPBMC infection with the Ad5[E1−,E2b−] vaccine also provoked greater Th1-dominant gene responses yet smaller amounts of Ad-derived gene expression than Ad5[E1−] vaccines. (asm.org)
  • There is currently no vaccine licensed for human use to protect against infection with VEEV, although two vaccines have been used under Investigational New Drug status in humans. (biomedcentral.com)
  • Prevention of adenovirus infection relies on healthy habits applicable for prevention of most viral infections. (news-medical.net)
  • Avoidance of close contact with a person ill with adenovirus infection. (news-medical.net)
  • The high prevalence of herpes simplex virus 2 (HSV-2) infections in humans necessitates the development of a safe and effective vaccine that will need to induce vigorous T-cell responses to control viral infection and transmission. (duke.edu)
  • Our results demonstrated the immunogenicity and protective efficacy of recombinant adenovirus vaccines in acute HSV-2 infection following intravaginal challenge in mice. (duke.edu)
  • These vaccines cause what is essentially a subclinical infection with PPRV, and therefore the antibody signatures of vaccinated and previously-infected animals are identical. (biomedcentral.com)
  • The Department and local health partners have been working with the facility to provide infection control recommendations and identify other possible illnesses since the [Voorhees] facility notified the Department of a case of adenovirus in a resident on October 26," New Jersey Department of Health Commissioner Dr. Shereef Elnahal said in a statement Monday. (fox40.com)
  • An adenovirus infection can be potentially life-threatening, especially for children after a stem cell transplant. (tum.de)
  • They observed marked changes in what are called PML nuclear, complexes made up of several proteins within the cell, in cases of adenovirus infection. (tum.de)
  • Symptoms of respiratory illness caused by adenovirus infection range from the common cold syndrome to pneumonia , croup , and bronchitis . (wikipedia.org)
  • Patients with compromised immune systems are especially susceptible to severe complications of adenovirus infection. (wikipedia.org)
  • Some adenoviruses (e.g., serotypes 1, 2, 5, and 6) have been shown to be endemic in parts of the world where they have been studied, and infection is usually acquired during childhood. (wikipedia.org)
  • for example, infection with adenovirus 7 acquired by inhalation is associated with severe lower respiratory tract disease, whereas oral transmission of the virus typically causes no or mild disease. (wikipedia.org)
  • [8] Strict attention to good infection-control practices is effective for stopping transmission in hospitals of adenovirus-associated disease, such as epidemic keratoconjunctivitis. (wikipedia.org)
  • This vaccine prevents viral shedding caused by canine parvovirus infection. (petceutics.com.au)
  • Outbreaks of adenovirus infection can occur in anyone at any time of year. (emedicinehealth.com)
  • What Are Reported Outbreaks of Adenovirus Infection? (emedicinehealth.com)
  • Outbreaks of adenovirus infection can occur throughout the year. (emedicinehealth.com)
  • What Are Signs and Symptoms of an Adenovirus Infection? (emedicinehealth.com)
  • You can get an adenovirus infection at any age. (emedicinehealth.com)
  • Sometimes the virus can be shed (released from the body) for a long time after a person recovers from an adenovirus infection, especially among people who have weakened immune systems. (emedicinehealth.com)
  • There is no specific treatment for people with adenovirus infection. (emedicinehealth.com)
  • A vaccine specific for adenovirus types 4 and 7 was approved by the U.S. Food and Drug Administration in March 2011, for use only in U.S. military personnel who may be at higher risk for infection from these two adenovirus types. (emedicinehealth.com)
  • Patient A had a respiratory infection with adenovirus type 14, which was confirmed by testing of a nasal wash specimen. (cdc.gov)
  • A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection of control virus replication after a limiting-dose heterologous SIV challenge. (biolifesolutions.com)
  • The current vaccine pipeline does not include strategies which prevent or eliminate infection with the causative agent Mycobacterium tuberculosis (Mtb). (nih.gov)
  • Qualitatively superior vaccines should be capable of preventing or eliminating Mtb infection, in this way eliminating the risk of TB reactivation. (nih.gov)
  • Fulminant hepatic failure caused by adenovirus infection following bone marrow transplantation for Hodgkin’s disease. (ebscohost.com)
  • However, fulminant hepatic failure due to adenovirus infection as a fatal complication in bone marrow transplant recipients is extremely rare. (ebscohost.com)
  • Respiratory illness symptoms caused by adenovirus infection range from common cold symptoms, pharyngitis, and rhinitis, to bronchitis or pneumonia. (health.mil)
  • Young infants and patients with compromised immune systems are more susceptible to severe complications from adenovirus infection. (health.mil)
  • What are the symptoms of adenovirus infection? (health.mil)
  • Strict attention to good infection-control practices, including contact and droplet precautions is effective for stopping nosocomial outbreaks of adenovirus associated disease. (health.mil)
  • DA2PPC does not include vaccination against Bordetella, but the combination of Bordetella with DA2PPC significantly reduces kennel cough infection through prevention of adenovirus, distemper, and parainfluenza. (wikipedia.org)
  • Type 1 adenovirus, also called canine hepatitis, is a DNA viral upper respiratory infection contracted through contact of a mucous membrane. (wikipedia.org)
  • In some cases, your health care provider may decide to postpone adenovirus vaccination to a future visit. (cdc.gov)
  • Virus from the vaccine can be shed in the stool for up to 28 days after vaccination. (cdc.gov)
  • More serious problems including blood in the urine or stool, pneumonia, or inflammation of the stomach or intestines occur rarely after adenovirus vaccination. (cdc.gov)
  • Vaccination is an effective way of reducing the numbers of infected individuals provided there is a good match between the vaccine and the circulating strains. (springer.com)
  • Upon subcutaneous vaccination with the adenovirus-PSA prostate cancer vaccine, the adenovirus infects cells and expresses PSA. (cancer.gov)
  • Vaccinees also may participate in a substudy in which they receive a booster vaccination with the licensed Influenza Virus Vaccine, H 5 N1 (Sanofi Pasteur). (clinicaltrials.gov)
  • The 1999 cessation of vaccination against adenovirus types 4 and 7 among US Army trainees resulted in reemergence of acute respiratory disease (ARD) outbreaks. (cdc.gov)
  • The 2011 implementation of a replacement vaccine led to dramatic and sustained decreases in ARD cases, supporting continuation of vaccination in this population at high risk for ARD. (cdc.gov)
  • Routine use of oral adenovirus type 4 and 7 (AdV-4 and -7) vaccine began in 1971 and eventually included year-round vaccination, resulting in plummeting ARD rates ( 1 ). (cdc.gov)
  • The presence of various levels of anti-adenovirus serotype 5 (Ad5)-neutralizing antibodies in humans is thought to contribute to the inconsistent clinical results obtained so far in diverse gene transfer and vaccination studies and might preclude universal dosing with recombinant Ad5. (asm.org)
  • Understanding and improving the molecular components of adenovirus-based vaccines can produce potent, optimized product, useful for vaccination and post-exposure therapy. (utexas.edu)
  • Intramuscular vaccination fully protected nonhuman primates in the absence of preexisting immunity, whereas the presence of preexisting immunity abrogated vaccine efficacy and resulted in complete mortality. (asm.org)
  • This study shows that airway vaccination with adenovirus serotype 5-based Ebola virus vaccine can efficiently bypass preexisting immunity to adenovirus serotype 5 and induce protective immune responses, albeit at lower efficacy than that using an intramuscular vaccine delivery route. (asm.org)
  • Alternatively, it is possible to bypass AdHu5 PEI by altering the route of vaccine delivery from the conventional intramuscular (i.m.) injection which typically stimulates systemic responses ( 10 , 20 , 28 ) to an airway route of vaccination capable of inducing both mucosal and systemic immune responses in both the mouse and guinea pig animal models ( 29 - 33 ). (asm.org)
  • Here, we developed two Adenovirus (Ad) vectored Zika virus vaccines by inserting a ZIKV prM-E gene expression cassette into human Ad types 4 (Ad4-prM-E) and 5 (Ad5-prM-E). Immune correlates indicate that Ad5-prM-E vaccination induces both an anti-ZIKV antibody and T-cell responses whereas Ad4-prM-E vaccination only induces a T-cell response. (unl.edu)
  • The study and characterization of recombinant adenovirus (Ad) vaccine platforms, particularly Ad serotype 5 (Ad5) vaccine platforms, are of great interest for their development and clinical application for human vaccination. (asm.org)
  • After contracting a new manufacturer, adenovirus vaccination of military basic trainees resumed in 2011. (utexas.edu)
  • Two decision tree models comparing adenovirus vaccination to no adenovirus vaccination were used for this dissertation. (utexas.edu)
  • Results from part I indicated that adenovirus vaccination of basic trainees was cost-effective as measured by FRI hospitalizations prevented in all US military service branches but the Coast Guard. (utexas.edu)
  • In part II of this study, adenovirus vaccination of basic trainees was the dominant strategy as measured by TDL averted in all US military service branches but the Marine Corps and the Coast Guard. (utexas.edu)
  • A dramatic decrease in adenovirus outbreaks was related to a vaccination program against adenovirus types 4 and 7, which was begun in 1971 ( 6 , 7 ). (cdc.gov)
  • Preexposure vaccination with the licensed TB vaccine BCG prevents severe forms of TB in children but not in adolescents and adults. (nih.gov)
  • FRIDAY, July 24, 2020 (HealthDay News) - A chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19) expressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein has acceptable safety and induces antibody and T-cell immune responses, according to a study published online July 20 in The Lancet . (physiciansweekly.com)
  • Here, we constructed a recombinant rare serotype of the chimpanzee adenovirus 68 (AdC68) that expresses full-length MERS-CoV S protein (AdC68-S). Single intranasal immunization with AdC68-S induced robust and sustained neutralizing antibody and T cell responses in BALB/c mice. (unboundmedicine.com)
  • This new guideline combines and replaces the formerly separate list of tests found in the Guidelines Pandemic COVID-19 Vaccine (Non-replicating Chimpanzee Adenovirus-vectored COVID-19 Vaccine) and Pandemic COVID-19 Vaccine (Non-replicating Human Adenovirus-vectored COVID-19 Vaccine), which entered into force on 12 November 2020. (edqm.eu)
  • The n e w e ng l a n d j o u r na l of m e dic i n e original article A Monovalent Chimpanzee Adenovirus Ebola Vaccine - Preliminary Report Tommy Rampling, M.R.C.P., Katie Ewer, Ph.D., Georgina Bowyer, B.A., Danny Wright, M.Sc. (exploredoc.com)
  • We assessed a monovalent formulation of a chimpanzee adenovirus 3 (ChAd3)-vectored vaccine encoding the surface glycoprotein of Zaire ebolavirus (EBOV), matched to the outbreak strain. (exploredoc.com)
  • In mice and humans, ChAdOx1 (chimpanzee adenovirus Ox1) immunization robustly activated MAIT cells. (jenner.ac.uk)
  • however, prostate cancer vaccines to date demonstrate modest efficacy and low immunogenicity. (medworm.com)
  • Unexpectedly, the high vaccine immunogenicity translated into relatively low protective efficacy in the murine transplantable and spontaneous models of prostate cancer. (medworm.com)
  • In an overall evaluation of the Russian vaccine, Brazil?s regulators found its safety and efficacy were based on insufficient, limited, and sometimes faulty data and analyses. (flutrackers.com)
  • The protection seen in these highly lethal mouse models demonstrate the efficacy of Ad vectored vaccines for use against ZIKV. (unl.edu)
  • This is the first randomised controlled trial for assessment of the immunogenicity and safety of a candidate non-replicating adenovirus type-5 (Ad5)-vectored COVID-19 vaccine, aiming to determine an appropriate dose of the candidate vaccine for an efficacy study. (physiciansweekly.com)
  • These results suggest that Ad5[E1−,E2b−] vaccines, in contrast to Ad5[E1−] vaccines, do not promote activities that suppress innate immune signaling, thereby allowing for improved vaccine efficacy and a superior safety profile independently of previous Ad5 immunity. (asm.org)
  • Following administration of this vaccine to Balb/c mice, an approximately ten-fold increase in antibody response was elicited and increased protective efficacy compared to an ad-based vaccine containing non-optimised genes was observed after challenge. (biomedcentral.com)
  • This study, in which the utility of optimising genes encoding the structural proteins of VEEV is demonstrated for the first time, informs us that including optimised genes in gene-based vaccines for VEEV is essential to obtain maximum immunogenicity and protective efficacy. (biomedcentral.com)
  • These vaccine candidates warrant further clinical evaluation of efficacy to assess their potential to reduce the burden of RSV disease. (ox.ac.uk)
  • Using local animals, we have analysed the immunogenicity and protective efficacy of different doses of vaccine, in order to determine the minimum protective dose. (biomedcentral.com)
  • Biomanufacturing of large amounts of the ChAd3 vaccine was a limiting factor in the development of an accelerated plan to undertake large-scale efficacy trials and deployment. (exploredoc.com)
  • The researchers tested the efficacy of ATO in cell cultures infected with adenoviruses. (tum.de)
  • The clinical trial is the research trial performed in humans to ensure the safety and efficacy of the vaccine at hand. (news24.com)
  • The pharmaceutical industry has made significant contributions to HIV vaccine research, but it has been rare for a major company to take the leading role in propelling a candidate toward efficacy testing. (typepad.com)
  • Given Merck's cautionary tale, it is all the more notable that Janssen Vaccines and Prevention B.V. is now rapidly advancing an experimental prime-boost HIV vaccine regimen, with plans announced at the IAS 2017 conference to launch a large scale "proof of concept" efficacy trial in women in late 2017/early 2018. (typepad.com)
  • An iterative process involving both macaque and human studies has been ongoing, informing decisions about which versions of the vaccine constructs and which HIV antigens will be selected for efficacy evaluations. (typepad.com)
  • Large-scale studies of the new vaccine in U.S. military recruits showed high efficacy rates in preventing wild type 4 adenovirus-associated febrile acute respiratory disease and inducing neutralizing antibody to type 7 adenovirus. (health.mil)
  • Two of the vaccines in Operation Warp Speed are subunit vaccines, where the company is making viral proteins that will be used as the vaccine. (futurity.org)
  • The MERS-CoV envelope spike protein serves as a crucial target for neutralizing antibodies and vaccine development, as it plays a critical role in mediating viral entry through interactions with the cellular receptor, dipeptidyl peptidase 4 (DPP4). (unboundmedicine.com)
  • Both doses of the vaccine induced significant neutralising antibody responses to live SARS-CoV-2, with GMTs of 19·5 (95% CI 16·8-22·7) and 18·3 (14·4-23·3) in participants receiving 1 × 10 and 5 × 10 viral particles, respectively. (physiciansweekly.com)
  • The Ad5-vectored COVID-19 vaccine at 5 × 10 viral particles is safe, and induced significant immune responses in the majority of recipients after a single immunisation. (physiciansweekly.com)
  • In studies comparing these two types of Ads, Ad5[E1−,E2b−] vaccines have been found to promote the decreased expression of viral proteins, persist longer in vivo , and induce less virus-associated toxicity following in vivo administration ( 16 , 28 , 29 ). (asm.org)
  • Like most other viral infections, there are no specific drugs that can target the adenovirus. (news-medical.net)
  • Vaccines work by teaching your body how to recognize the foreign invader, usually by introducing pieces of that invader in the form of viral proteins, inactivated virus, or attenuated virus. (medscape.com)
  • Methods After expedited regulatory and ethics approvals, 60 healthy adult volunteers in Oxford, United Kingdom, received a single dose of the ChAd3 vaccine at one of three dose levels: 1×1010 viral particles, 2.5×1010 viral particles, and 5×1010 viral particles (with 20 participants per group). (exploredoc.com)
  • Replication competent viruses are used to produce live attenuated vaccines that usually elicit life-long protection against viral disease. (breastcarenetwork.com)
  • At IAS 2017 Hannah Schuitemaker, Vice President and Head of Viral Vaccine Discovery and Translational Medicine at Janssen Vaccines and Prevention B.V., presented results from a key clinical trial named APPROACH (the company has chosen monikers from mountaineering terminology to designate their steps toward the hoped-for summit of a licensable HIV vaccine). (typepad.com)
  • Adenovirus type 2 is responsible for the infectious, viral disease kennel cough. (wikipedia.org)
  • This vaccine elicited immunity to adenovirus serotypes 4 and 7, the serotypes most often associated with acute respiratory disease. (wikipedia.org)
  • It is possible to circumvent PEI to AdHu5 by either increasing the adenoviral vaccine dose ( 23 ), by using rare human serotypes, such as AdHu12, AdHu35 ( 24 ), and AdHu6 ( 25 ), or by using adenoviruses from other species, such as simian ( 26 ), bovine ( 27 ), and porcine. (asm.org)
  • Vaccines against these two serotypes controlled FRI in basic trainees until production ceased in the mid-1990s. (utexas.edu)
  • for example, epidemic keratoconjunctivitis is associated with adenovirus serotypes 8, 19, and 37. (wikipedia.org)
  • Safe and effective adenovirus vaccines were developed for adenovirus serotypes 4 and 7, but were available only for preventing ARD among US military recruits, [7] and production stopped in 1996. (wikipedia.org)
  • [2] [3] This vaccine elicited immunity to serotypes 4 and 7. (worldheritage.org)
  • There are at least 52 immunologically distinct serotypes of adenoviruses that can cause human infections. (health.mil)
  • In the United States, adenovirus serotypes 4 and 7 most commonly cause respiratory illness. (health.mil)
  • Some adenovirus serotypes can establish persistent asymptomatic infections in tonsils, adenoids, and intestines of infected people who can shed these viruses for months or years. (health.mil)
  • If you have had a different COVID-19 vaccine. (mskcc.org)
  • BRASILIA -- The Brazilian health regulator Anvisa on Monday rejected importing the Russian-made Sputnik V COVID-19 vaccine requested by state governors battling a deadly second wave of the virus that is battering Latin America's largest nation. (flutrackers.com)
  • Russia sold 100 million doses of the coronavirus (COVID-19) vaccine Sputnik V to India, which was also among the countries that produced it on its territory. (flutrackers.com)
  • The new Official Control Authority Batch Release (OCABR) Guideline for Pandemic COVID-19 Vaccine (Recombinant Spike Protein) , containing the agreed list of tests to be performed by Official Medicines Control Laboratories (OMCLs) for OCABR, is now available and is in force from 20 April 2021. (edqm.eu)
  • The new OCABR Guideline for Pandemic COVID-19 Vaccine (Non-replicating Adenovirus-vectored COVID-19 Vaccine) , in force from 1 May 2021, is also available. (edqm.eu)
  • Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial. (physiciansweekly.com)
  • This randomised, double-blind, placebo-controlled, phase 2 trial of the Ad5-vectored COVID-19 vaccine was done in a single centre in Wuhan, China. (physiciansweekly.com)
  • How Do We Know the COVID-19 Vaccine Won't Have Long-Term Side Effects? (flipboard.com)
  • A COVID-19 vaccine is any of the vaccines used against the Coronavirus Disease 2019 ( COVID-19 pandemic ). (wikipedia.org)
  • One of South Africa's three COVID-19 vaccine trials was recently put on hold after a participant in the United Kingdom developed an unexplained illness. (avac.org)
  • Australian Genene Norris , 48, and Canadian Francine Boyer , 54 both died a few days after having the COVID-19 vaccine from AstraZeneca. (thebl.tv)
  • Once the adenovirus begins to replicate, the DNA code that it was supposed to carry into the cells becomes disabled, rendering the shot ineffective as a covid-19 vaccine. (immunization.news)
  • The immunization of macaques induced vigorous humoral responses to adenovirus capsid and nonstructural proteins, although, surprisingly, not against HPV L1. (asm.org)
  • In contrast, immunization elicited strong T-cell responses to HPV VLPs as well as adenovirus virions. (asm.org)
  • Live recombinant adenoviruses (rAds) used in a similar manner might prove to be powerful tools for immunization against other pathogens, especially in low-resource settings. (asm.org)
  • A single immunization with either of the vaccines conferred protection against RVF virus challenge eight weeks post-immunization. (biomedcentral.com)
  • A successful immunization program against adenovirus types 4 and 7 was terminated in 1999. (cdc.gov)
  • Co-administration of the prime-boost vaccine regimens induced high magnitude and broad T cell responses that were similar to those observed following immunization with either regimen alone. (frontiersin.org)
  • We aim to develop an effective vaccine able to induce long lasting protection using a simplified immunization schedule. (grantome.com)
  • The quadrivalent vaccine presented here produced immune responses that we predict should be capable of providing protection against multiple influenza strains, and the platform should have applications to other multivalent vaccines. (springer.com)
  • The molecular modifications of the new improved vaccine also translated in the induction of significantly enhanced immune responses and complete protection at a dose 100 times lower than with the previous generation adenovirus-based Ebola vaccine. (utexas.edu)
  • Immune responses were evaluated to determine the effect of both the vaccine delivery route and preexisting immunity before and after a lethal Ebola virus (Zaïre strain Kikwit 95) challenge. (asm.org)
  • Fundamental questions persist about where the virus hides in the body and which immune responses most effectively can foil it-and answers may lead to the still elusive HIV vaccine and cure. (sciencemag.org)
  • BACKGROUNDTo understand the features of a replicating vaccine that might drive potent and durable immune responses to transgene-encoded antigens, we tested a replication-competent adenovirus type 4 encoding influenza virus H5 HA (Ad4-H5-Vtn) administered as an oral capsule or via tonsillar swab or nasal spray.METHODSViral shedding from the nose, mouth, and rectum was measured by PCR and culturing. (meta.org)
  • as multiple inbred and outbred lines are available, mice can be generated in large numbers at fairly low costs and numerous tools to analyze vaccine and virally induced immune responses are available. (medscape.com)
  • Anti-adenovirus serotype 5 antibodies are capable of neutralizing adenovirus serotype 5-based vaccines. (asm.org)
  • Approximately 90% of sub-Saharan African and southeast Asian populations and an estimated 35% of the North America population have anti-AdHu5 antibodies capable of neutralizing AdHu5-based vaccines ( 21 , 22 ). (asm.org)
  • Neutralizing antibodies against sAd24 were determined using a panel of 106 rhesus macaque sera and 128 human sera from Rwanda and South Africa using a luciferase-based adenovirus neutralization assay. (biomedcentral.com)
  • The group will also look for antibodies against platelet factor 4 in recipients of various COVID vaccines. (breastcarenetwork.com)
  • Vaccines safely expose the body to pathogens so that the immune system can make antibodies capable of binding to their antigens. (medicalnewstoday.com)
  • Adenovirus vaccine contains live adenovirus Type 4 and Type 7. (cdc.gov)
  • Concurrent administration of live adenovirus, type 4 and live Poliovirus, type 1 vaccines. (semanticscholar.org)
  • The induction of a strong cellular response by the recombinant indicates that live adenovirus recombinants have potential as vaccines for those agents. (asm.org)
  • Live adenovirus vaccines have been used by the United States military for decades to prevent adenovirus type 4 (Ad4)- and Ad7-induced severe upper respiratory disease in recruits ( 1 ). (asm.org)
  • Additionally, numerous studies have demonstrated the tremendous ability of Ad5-based vaccines to create robust, transgene-specific cell-mediated immunity against antigens derived from pathogens, such as HIV ( 2 - 8 ), the malaria parasite ( 9 , 10 ), and Mycobacterium tuberculosis ( 11 , 12 ), as well as many tumor-associated antigens ( 13 - 17 ). (asm.org)
  • Activation of MAIT cells positively correlated with vaccine-induced T cell responses in human volunteers and MAIT cell-deficient mice displayed impaired CD8+ T cell responses to multiple vaccine-encoded antigens. (jenner.ac.uk)
  • Vaccines expose the body to pathogenic antigens. (medicalnewstoday.com)
  • Despite this, the vaccine still stimulates the body to recognize its antigens. (medicalnewstoday.com)
  • Other types of adenovirus infections can cause flu-like symptoms, pinkeye and diarrhea. (fox40.com)
  • There is no vaccine available for the general public, although a vaccine against two types of adenovirus is available for U.S. military personnel. (emedicinehealth.com)
  • Cidofovir is an antiviral agent that has been used to treat severe adenovirus infections in people with suppressed or low immune systems. (news-medical.net)
  • Generally speaking, every adult has probably had several adenovirus infections already,' says Dr. Sabrina Schreiner. (tum.de)
  • We've known that adenovirus infections in healthy patients can also cause severe pneumonia ending in death since 2006,' says Schreiner. (tum.de)
  • Following laboratory testing, in the next step the medication will be used on patients with adenovirus infections. (tum.de)
  • In order to protect children who undergo stem cell therapy from adenovirus infections, scientists intend to develop new methods for detecting even very small amounts of the viruses in the patient and the donor before the therapy. (tum.de)
  • Acute respiratory disease (ARD), first recognized among military recruits during World War II, can be caused by adenovirus infections during conditions of crowding and stress. (wikipedia.org)
  • however, adenovirus infections can occur throughout the year. (wikipedia.org)
  • Antigen detection, polymerase chain reaction assay, virus isolation , and serology can be used to identify adenovirus infections. (wikipedia.org)
  • [8] On 4 May 2020, the WHO organized a telethon (fundraising event broadcasted via televisions) to raise US$8 billion from forty countries to support rapid development of vaccines to prevent COVID-19 infections and deaths. (wikipedia.org)
  • In most cases, adenoviruses do not cause any symptoms or signs, but in some people, they cause a range of illnesses including respiratory infections like the common cold , pinkeye , pneumonia , diarrhea , and inflammation of the bladder, intestines , or nervous system . (emedicinehealth.com)
  • How Do Adenovirus Infections Spread? (emedicinehealth.com)
  • Most adenovirus infections are mild and may require only care to help relieve symptoms. (emedicinehealth.com)
  • Review of records in the Mortality Surveillance Division, Armed Forces Medical Examiner System, identified 8 deaths attributed to adenovirus infections in service members during 1999-2010. (cdc.gov)
  • In the past few years, newly recognized infections with Zika, severe acute respiratory syndrome, Middle East respiratory syndrome viruses have pushed the US military to fund research and fast track clinical trials to quickly and effectively develop vaccines for emerging diseases. (frontiersin.org)
  • Lower Respiratory Tract Infections due to Adenovirus in Hospitalized Korean Children: Epidemiology, Clinical Features, and Prognosis. (ebscohost.com)
  • Presents a study which described the epidemiology, clinical features, and prognosis of lower respiratory tract infections (LRTI) due to adenovirus among hospitalized Korean children from November 1990 through February 1998. (ebscohost.com)
  • Adenovirus infections are frequently encountered in immunocompromised patients and transplant recipients. (ebscohost.com)
  • The purpose of this study is to compare the safety and immunogenicity over a 9-month period of five different dosages of Ad4-H 5- Vtn in volunteers (Vaccinees) who receive three doses of the study vaccine or placebo. (clinicaltrials.gov)
  • The purpose of this study is to determine the safety and immunogenicity of the recombinant adenovirus serotype 5 preventive HIV-1 vaccine. (clinicaltrials.gov)
  • We performed an open-label, dose escalation, phase 1 clinical trial in 42 healthy adults in which four different combinations of prime/boost vaccinations were investigated for safety and immunogenicity, including both intramuscular (IM) and intranasal (IN) administration of the adenovirus-vectored vaccine. (ox.ac.uk)
  • Certain adenovirus types (including Type 4 and Type 7) have caused severe outbreaks of respiratory illness among military recruits. (cdc.gov)
  • When the stock of AdV-4 and -7 vaccine was depleted, the Army's Acute Respiratory Disease Surveillance Program (ARD-SP), partnering with the Naval Health Research Center (San Diego, CA, USA) Febrile Respiratory Illness (NHRC FRI) Surveillance Program, demonstrated substantial increases in ARD cases, specifically adenovirus-associated ARD. (cdc.gov)
  • Adenoviruses, particularly types 4 and 7, are associated with febrile respiratory illness (FRI) outbreaks in US military basic trainees. (utexas.edu)
  • In its first year of use, adenovirus vaccine prevented 15,000 cases of Febrile Respiratory Illness, as evidenced by a reduction in the rate of Febrile Respiratory Illness that began soon after October 2011. (worldheritage.org)
  • Adenovirus serotype 14 (Ad14) is a rarely reported but emerging serotype of adenovirus that can cause severe and sometimes fatal respiratory illness in patients of all ages, including healthy young adults. (cdc.gov)
  • In the wild, the adenovirus normally causes mild respiratory illness in humans. (immunization.news)
  • In military enlisted training centers, adenoviruses have historically caused substantial and prolonged outbreaks of respiratory illness. (health.mil)
  • Adenoviruses most commonly cause respiratory illness. (health.mil)
  • A clinical trial testing a candidate HIV vaccine known as the STEP study was halted in September 2007 after interim analysis indicated that the vaccine did not work. (news-medical.net)
  • As noted by McElrath and colleagues, this is something that will have to be carefully evaluated in any future clinical trial of any adenovirus-based vaccine, not just Ad5-based vaccines and not just adenovirus-based vaccines for HIV. (news-medical.net)
  • Currently, replication defective adenovirus-based Ebola vaccine is being studied in a phase I clinical trial. (utexas.edu)
  • As a result, rAd5 vaccines for human immunodeficiency virus type 1 (HIV-1) and other pathogens are currently being advanced into large-scale clinical trials ( 5 , 14 , 24 ). (asm.org)
  • Importantly, anti-Ad5 immunity has already been shown to suppress the immunogenicity of rAd5 vaccines for HIV-1 in both preclinical studies ( 2 , 3 , 7 , 8 , 28 , 29 , 33 ) and clinical trials ( 24 ). (asm.org)
  • Such successes have encouraged the development of more replication-deficient adenovirus-based vaccine strategies and have led to a phase I clinical trial ( http://clinicaltrials.gov/show/NCT00374309 ). (asm.org)
  • Two companies, Sinovac and Sinopharm, both from China, have inactivated virus vaccines in clinical trials. (medscape.com)
  • The Sinopharm vaccine has already been approved for use by the Chinese military, and according to press reports has actually completed a 50,000-person clinical trial in the Middle East. (medscape.com)
  • This review describes the progress that has been made in producing and testing adenovirus-based Ebola vaccines in both pre-clinical and clinical studies, and considers the likely future use of these vaccines. (ox.ac.uk)
  • It is likely the vaccines last that long just based on clinical experience alone and it cuts down some on the reactions to extend the interval to every three years. (vetinfo.com)
  • With new vaccine formulations and technology platforms, vaccine developers need to have the right processes in place to manufacture them during clinical trials and at commercial scale. (terrapinn.com)
  • New Models: How are smaller product development organizations (biotechs/non-profit/academics) manufacturing vaccine products for early and exploratory PoC clinical trials? (terrapinn.com)
  • Through retrospective examination of laboratory reports from the three clinical laboratories in the state that have virology capacity and the Oregon State Public Health Laboratory (OSPHL), OPHD identified 68 persons who tested positive (by culture, PCR, or IFA) for adenovirus during November 1, 2006--April 30, 2007. (cdc.gov)
  • While 67 of those vaccines are still in a pre-clinical phase, three of the vaccines are taking the lead and have now been moved on to clinical trials. (news24.com)
  • This vaccine by CanSino Biological Inc. and the Beijing Institute of Technology is currently in stage two of clinical evaluation. (news24.com)
  • The vaccine is currently in stage one of clinical evaluation. (news24.com)
  • When a medication or vaccine goes to clinical trial, it has been through the necessary laboratory and animal tests. (news24.com)
  • A clinical trial is used to establish any possible side-effect that a vaccine may cause. (news24.com)
  • Human prostate tumor vaccine and gene therapy trials using ex vivo methods to prime dendritic cells (DCs) with prostate specific membrane antigen (PSMA) have been somewhat successful, but to date the lengthy ex vivo manipulation of DCs has limited the widespread clinical utility of this approach. (nih.gov)
  • A few therapeutic vaccines are under clinical assessment, as well. (nih.gov)
  • In July 2020, more than 150 vaccines were being developed in different laboratories. (wikipedia.org)
  • [1] Two mRNA vaccines , one by Pfizer and one by Moderna , were approved late in 2020. (wikipedia.org)
  • In late February 2020, the World Health Organization (WHO) said it did not expect a vaccine against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative virus, to become available in less than 18 months. (wikipedia.org)
  • Moreover, our data suggest that future T cell-focused vaccine design should aim to induce immunodominant responses to highly conserved regions of the virus. (iavi.org)
  • Many vaccines require an adjuvant to induce a strong immune response. (utexas.edu)
  • Given orally as enteric-coated tablets, the vaccines contain lyophilized Ad4 and Ad7 that induce both humoral and cell-mediated immunity as they replicate asymptomatically in the gut of the vaccinee. (asm.org)
  • We designed rAd-gD2, rAd-gD2ΔUL25, and rAd-ΔUL25 to investigate whether recombinant replication-defective adenoviruses vaccine could induce specific T-cell responses and protect mice against intravaginal HSV-2 challenge compared with FI-HSV-2. (duke.edu)
  • Surprisingly, the species D vaccines again failed to induce greater levels of protective immunity as compared with the species C Ad5 when delivered intramuscularly. (elsevier.com)
  • Approximately 3.8 million Russians received both doses of Sputnik V, a vaccine against the coronavirus (COVID-19) developed by the Gamaleya Research Center as of March 31, 2021. (flutrackers.com)
  • PittCoVacc is short for "Pittsburgh coronavirus vaccine. (wikipedia.org)
  • The World Health Organization ( WHO ) recently published a blueprint document that listed 70 vaccine candidates that were leading the way towards a solution to the coronavirus pandemic . (news24.com)
  • The global race is on for a vaccine to combat the coronavirus, but the question is: Who will be included? (avac.org)
  • Anne VanGeest , 35, of Ionia, died as a result of complications after getting the Johnson & Johnson coronavirus vaccine, according to her family. (thebl.tv)
  • Because infectious canine hepatitis is another name for canine adenovirus type 1, an H is sometimes used instead of A. In DA2PPC, the C indicates canine coronavirus. (wikipedia.org)
  • Distemper, adenovirus type 1 (thus hepatitis), parainfluenza, and parvovirus are covered by all 4, but only DAPPC covers coronavirus. (wikipedia.org)
  • This subset was tested for respiratory pathogens, including adenoviruses. (cdc.gov)
  • To explore the applicability of the live rAd platform to other pathogens, we constructed replication-competent adenovirus recombinants that make novel use of the high-level gene expression characteristic of the adenovirus major late transcriptional unit (MLTU) to produce papillomavirus L1 proteins ( 4 ). (asm.org)
  • The 2014 outbreak of Ebola virus disease in West Africa has highlighted the need for the availability of effective vaccines against outbreak pathogens that are suitable for use in frontline workers who risk their own health in the course of caring for those with the disease, and also for members of the community in the affected area. (ox.ac.uk)
  • When coupled with needle-free skin delivery, such a platform would address an unmet need in global vaccine coverage against HIV and other global pathogens. (elsevier.com)
  • Currently, adenovirus-based vaccines are used against a wide variety of pathogens, including Mycobacterium tuberculosis , human immunodeficiency virus (HIV), and Plasmodium falciparum . (avac.org)
  • For most people this probably won't be a big deal because adenoviruses are generally not thought of as really important human pathogens," said Rasmussen. (immunization.news)
  • Infectious Diseases of Estonia is one in a series of GIDEON ebooks which explore all individual infectious diseases, drugs, vaccines, outbreaks, surveys and pathogens in every country of the world. (worldcat.org)
  • Vaccines are products that help the immune system combat invading disease-causing pathogens. (medicalnewstoday.com)
  • Vaccines train the immune system to detect and combat disease-causing pathogens. (medicalnewstoday.com)
  • Toxoid vaccines use deactivated toxins to help prepare the immune system to fight off live pathogens. (medicalnewstoday.com)
  • It has been used in vaccine candidates against tuberculosis, HIV, Ebola , malaria and influenza. (fiercepharma.com)
  • The data further validate the use of the VIA to screen and select future HIV vaccine candidates. (iavi.org)
  • with more than 200 vaccine candidates in the pipeline and seven in phase 3 trials, we are in good shape to have a vaccine to help us in the fight against COVID-19. (medscape.com)
  • [6] The Coalition for Epidemic Preparedness Innovations (CEPI) - which is organizing a US$2 billion worldwide fund for fast investment and creation of vaccine candidates [7] - indicated in April that a vaccine may be available under emergency use protocols in less than 12 months or by early 2021. (wikipedia.org)
  • The Dutch biotech company Crucell, which Janssen acquired several years ago, initially produced the main vaccine candidates being studied. (typepad.com)
  • With hundreds of potential COVID vaccine candidates being tested around the world, here's a quick guide to which ones you should keep an eye on - and when we could see results. (avac.org)
  • In addition, the fact that a large fraction of HCV carriers is coinfected with HIV must be considered when assessing vaccine candidates. (medscape.com)
  • The simian adenovirus, ChAdOx1, and modified vaccinia Ankara virus, MVA, encoding a prostate cancer-associated antigen, the six transmembrane epithelial antigen of the prostate 1 (STEAP1), induced strong sustained antigen-specific CD8+ T-cell responses in C57BL/6 and BALB/c male mice. (medworm.com)
  • We have now tested lower doses of the vaccine, as well as AdH in combination with a similar construct expressing the PPRV F glycoprotein (AdF). (biomedcentral.com)
  • At the vaccine doses tested, both antibody and T-cell responses were detected but at levels lower than those induced in macaques protected by the same vaccine. (exploredoc.com)
  • Conclusions The ChAd3 monovalent vaccine against EBOV was immunogenic at the doses tested. (exploredoc.com)
  • Further, for those who did initiate the vaccine and then remained in service for at least six months, only 46.6 percent of servicewomen and 35.1 percent of servicemen completed the recommended three doses. (health.mil)
  • Other DA2 vaccines require 2 or 3 doses to stimulate an initial antibody response. (neotechvaccines.com)
  • A person will require several doses or booster shots of an inactivated vaccine to guarantee its effectiveness. (medicalnewstoday.com)
  • How many doses of adenovirus vaccine are needed? (health.mil)
  • Inactivated ND vaccines provide incomplete protection, while live vaccines, although protective, may cause disease in uninfected and unvaccinated birds. (idrc.ca)
  • Some use protective chemical shells-or even other viruses-to deliver the vaccine. (futurity.org)
  • We envision that our studies will provide valuable data to improve protective immune response induced by protein- based vaccines. (grantome.com)
  • Our findings indicate that more research will be required to identify the mechanisms that play a key role in the induction of protective immunity induced by species D Ad vaccines. (elsevier.com)
  • Maintaining adequate levels of chlorination is necessary for preventing swimming pool-associated outbreaks of adenovirus conjunctivitis. (wikipedia.org)
  • Adenovirus causes mild respiratory disease, gastroenteritis, and conjunctivitis in humans ( 19 ). (asm.org)
  • Human adenoviruses cause conjunctivitis, gastrointestinal illnesses and pneumonia, among other things. (tum.de)
  • Apart from respiratory involvement, illnesses and presentations of adenovirus include gastroenteritis , [1] conjunctivitis , cystitis , and rash illness. (wikipedia.org)
  • Epidemics of febrile disease with conjunctivitis are associated with waterborne transmission of some adenovirus types, often centering on inadequately chlorinated swimming pools and small lakes. (wikipedia.org)
  • In this report, we modified the common recombinant adenovirus serotype 5-based Ebola vaccine expressing the wild-type ZEBOV glycoprotein sequence from a CMV promoter (Ad-CMVZGP). (utexas.edu)
  • Conclusions/Significance -- We describe an improved adenovirus-based Ebola vaccine capable of affording post-exposure protection against lethal challenge in mice. (utexas.edu)
  • In mice and guinea pigs, intranasal delivery of adenovirus serotype 5-based vaccine bypasses induced adenovirus serotype 5 preexisting immunity, resulting in protection against species-adapted Ebola virus challenge. (asm.org)
  • In contrast, the presence of preexisting immunity to adenovirus serotype 5 did not alter the survival rate of nonhuman primates receiving the adenovirus serotype 5-based Ebola virus vaccine in the airway. (asm.org)
  • 1 The T n e w e ng l a n d j o u r na l he current outbreak of Ebola virus disease (EVD) in West Africa has led to more than 8500 deaths.1 An effective vaccine may be necessary to contain this international public health emergency. (exploredoc.com)
  • Adenovirus-vectored Ebola vaccines. (ox.ac.uk)
  • Examples of replication-deficient adenovirus vaccines undergoing human trials include those developed against HIV, Ebola virus, influenza virus, Mycobacterium tuberculosis, and Plasmodium falciparum. (breastcarenetwork.com)
  • The vaccine is based on the same platform as the Ebola virus. (news24.com)
  • In this study, the immunogenicity of orally delivered monovalent, bivalent, trivalent, and quadrivalent vaccines was tested in ferrets and mice. (springer.com)
  • A combination of the vaccine with PD-1 blocking antibody significantly improved survival of the animals, with 80 % of mice remaining tumour-free. (medworm.com)
  • Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice. (duke.edu)
  • In the present study, recombinant adenovirus-based HSV-2 showed higher reductions in mortality and stronger antigen-specific T-cell responses compared with FI-HSV-2 and the severity of genital lesions in mice immunized with rAd-gD2ΔUL25 was significantly decreased by eliciting IFN-γ-secreting T-cell responses compared with rAd-gD2 and rAd-ΔUL25 groups. (duke.edu)
  • The feasibility of gene therapy for CAH was studied using 21OH-deficient mice (21OH−) and a replication-deficient adenovirus containing the genomic sequence of human CYP21 (hAdCYP21). (nature.com)
  • To protect against the major circulating A and B influenza strains, a multivalent influenza vaccine will be required. (springer.com)
  • We have developed a nonreplicative adenovirus-vectored influenza vaccine that can be produced without the prerequisite of growing influenza virus. (nih.gov)
  • A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity. (meta.org)
  • Both vaccines elicited RVF virus neutralizing antibody and a robust CD8 + T cell response. (biomedcentral.com)
  • Adenovirus also was isolated by culture, confirmed by immunofluorescence assay (IFA), and typed as Ad14 by antibody neutralization assay. (cdc.gov)
  • No new vaccine has been first tested in humans and rapidly developed within months in an attempt to control a major infectious disease outbreak. (exploredoc.com)
  • While Janssen is taking the lead, the program is a large collaboration including the Beth Israel Deaconess Medical Center (BIDMC), the Bill & Melinda Gates Foundation, the National Institute of Allergy and Infectious Diseases (NIAID), the HIV Vaccine Trials Network (HVTN), the International AIDS Vaccine Initiative, the US Military HIV Research Program, the Ragon Institute and the Los Alamos National Laboratory. (typepad.com)
  • Their experience informed vaccine development for many infectious diseases ( 4 , 6 , 7 ). (frontiersin.org)
  • If the genetically modified adenovirus reverts to a live, infectious form in the human body, it can make people sick, especially those with weaker immune systems. (immunization.news)
  • The vaccine might be intended to create herd immunity, but it could inadvertently weaken herd immunity and promote the spread of new infectious virus material in the community. (immunization.news)
  • Has had an allergic reaction after a previous dose of adenovirus vaccine , or has any severe, life-threatening allergies . (cdc.gov)
  • As with any medicine, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death. (cdc.gov)
  • In addition, a threat existed for the emergence of other adenovirus types that could cause severe and fatal disease ( 5 ). (cdc.gov)
  • Adenoviruses can cause mild to severe illness, though serious illness is less common. (emedicinehealth.com)
  • Despite the promising attributes associated with the adenoviral-based vaccine platforms, an inherent drawback exists if prior exposure and subsequent immune response to AdHu5 leads to preexisting immunity (PEI). (asm.org)
  • After the only manufacturer of the adenovirus vaccines ended production, adenoviral respiratory disease resurged after the phased cessation and eventual termination of adenovirus vaccinations during 1996-1999 ( 3 , 4 , 8 ). (cdc.gov)
  • The nasal vaccine was more potent than its epicutaneous counterpart under the adjuvant-free experimental condition. (nih.gov)
  • Adenoviruses are very common viruses that infect humans. (emedicinehealth.com)
  • They found that the genetically weakened adenovirus is still "replication-competent" and can rapidly multiply once it's injected into humans. (immunization.news)
  • Pedro M. Folegatti, from the Jenner Institute at the University of Oxford in the United Kingdom, and colleagues conducted a phase 1/2, single-blind, randomized trial of a ChAdOx1 nCoV-19 compared to a meningococcal conjugate vaccine (MenACWY) as control. (physiciansweekly.com)
  • Several authors are named as inventors on a patent relating to ChAdOx1-vectored vaccines and this specific vaccine. (physiciansweekly.com)
  • The vaccine induced responses to a median of 4 epitopes per vaccinee. (iavi.org)
  • In this study, we investigated the role of respiratory macrophage (MΦ) in regulating CD4 T cell responses to recombinant adenovirus-based (rAd) vaccines. (uzh.ch)
  • Even in the presence of anti-Ad5 immunity, recent murine and human studies have confirmed E2b gene-deleted Ad5 (Ad5[E1−,E2b−]) vaccines to be highly efficacious inducers of transgene-specific memory responses and significantly less toxic options than Ad5[E1−] vaccines. (asm.org)
  • A cancer vaccine composed of a genetically engineered, replication-deficient type 5 adenovirus carrying the human prostate-specific antigen (PSA), with potential immunostimulating and antineoplastic activities. (cancer.gov)
  • The vaccine developed by Inovio Pharmaceuticals is based on the same platform as Lassa, Nipah, Filovirus, HPV, Zika and Hepatitis B. A DNA plasmid vaccine is a vaccine where genetically engineered plasmid containing a DNA sequence that decodes the specific antigen against a virus is injected. (news24.com)
  • The mRNA sequence in the vaccine is coded to a disease specific antigen, which is recognised by the immune system, which then prepares to fight the virus. (news24.com)
  • This is called a subunit vaccine. (futurity.org)
  • However, replication-deficient or subunit vaccines generally result in protection of more limited duration. (breastcarenetwork.com)
  • Adenoviruses cause a wide range of illnesses, depending on the virus type. (health.mil)
  • Current vaccines against ND are either live or inactivated ND viruses. (idrc.ca)
  • Three of the vaccines use different viruses that we've engineered to be harmless, but are still capable of inducing your cells to make the proteins we need your immune system to respond to. (futurity.org)
  • Adenoviruses are double-stranded DNA viruses measuring 34-43 kilobases. (breastcarenetwork.com)
  • Adenoviruses are common viruses that cause a range of illness. (emedicinehealth.com)
  • Virus production for vaccines is still a challenging issue, particularly with slow-growing viruses such as influenza. (idrc.ca)
  • Adenoviruses are medium-sized, nonenveloped icosohedral viruses containing double-stranded DNA. (health.mil)
  • DA2PP is a multivalent vaccine for dogs that protects against the viruses indicated by the alphanumeric characters forming the acronym: D for canine distemper, A2 for canine adenovirus type 2, which offers cross-protection to canine adenovirus type 1 (the more pathogenic of the two strains) (see Canine adenovirus), the first P for canine parvovirus, and the second P for parainfluenza. (wikipedia.org)
  • The proposed project will use a non-replicative adenovirus to express two major antigenic determinants of protection against ND: the glycoprotein HN and the F protein. (idrc.ca)
  • Recombinant adenoviruses expressing the EBOV glycoprotein (GP) mixed with AdHu5 expressing the EBOV nucleoprotein (NP) offered complete protection in nonhuman primates (NHP) against lethal EBOV challenge ( 18 , 20 ). (asm.org)
  • We have previously shown that recombinant, replication-defective, adenovirus expressing the PPRV H glycoprotein (AdH) gives full protection against wild type PPRV challenge. (biomedcentral.com)
  • We have also compared the protection induced by Ad5-H alone to that induced by a vaccine combining Ad5-H with a similar construct expressing the other PPRV surface glycoprotein, F. (biomedcentral.com)
  • In this study, nonhuman primates were vaccinated with adenovirus serotype 5-based vaccine either intramuscularly or via the airway route (intranasally/intratracheally) in the presence or absence of adenovirus serotype 5 preexisting immunity. (asm.org)
  • Ad14 (for adenovirus serotype 14 ), has caused at least 140 illnesses in New York, Oregon, Texas and Washington, according to a report from the Centers for Disease Control and Prevention. (wikipedia.org)
  • The dog vaccines protect against the most common illnesses. (vetinfo.com)
  • England and Wales experienced the spread of illnesses due to adenovirus type 7 during the years 1972 and 1974. (ebscohost.com)
  • The vaccine is recommended by the U.S. Department of Defense for military recruits to prevent acute respiratory disease. (news-medical.net)
  • We have described a live recombinant adenovirus vaccine prototype that produces abundant HPV16 L1 protein from the adenovirus major late transcriptional unit and directs the assembly of HPV16 VLPs in tissue culture. (asm.org)
  • Two HPV vaccines have been licensed: Gardasil and Cervarix, which both contain HPV16 and HPV 18 virus-like particles (VLPs) composed of recombinant L1, the HPV major capsid protein. (asm.org)
  • The Moderna mRNA vaccine encodes the spike protein. (medscape.com)
  • They say mRNA vaccines take less time to develop and make, than protein or whole-virus vaccines. (wikipedia.org)
  • Western blot analysis of PSMA protein levels in adenovirus-infected dendritic cells. (nih.gov)
  • This type of vaccine contains an isolated protein or sugar from the pathogen. (medicalnewstoday.com)
  • Immunisation of healthy dogs, 6 weeks of age or older to protect against disease caused by canine distemper virus, canine adenovirus type 1, canine adenovirus type 2 and canine parvovirus. (petceutics.com.au)
  • The DA2PPC vaccine protects against the debilitating and deadly disease canine distemper. (wikipedia.org)
  • We continue to offer the Pfizer-BioNTech and Moderna vaccines to our eligible patients. (mskcc.org)
  • Two companies, Pfizer and Moderna, are betting on something different - an RNA vaccine. (medscape.com)
  • FDA recently granted Emergency Use Authorization (EUA) for the Pfizer and Moderna COVID-19 vaccines. (rarediseases.org)
  • This vaccine candidate by Moderna/NIAID and is designed to fight an RNA virus such as SARS-CoV-2. (news24.com)
  • To date, several companies have reached Phase 3 trials for an experimental vaccine - including Moderna, Pfizer, AstraZeneca and CanSino. (avac.org)
  • The AstraZeneca and Johnson & Johnson experimental adenovirus COVID shots appear to be far more deadly to younger and middle-aged people, people compared to the mRNA shots from Pfizer and Moderna. (thebl.tv)
  • In a statement about their database, EudraVigilance said that their report covers data collected through April 24, 2021, for four experimental vaccines currently in use in Europe from Pfizer, AstraZeneca, Moderna, and Johnson & Johnson. (thebl.tv)
  • Researchers and clinicians from all over the world are advancing the development of a vaccine against novel human SARS-CoV-2 using various approaches. (mdpi.com)
  • Separately, MilliporeSigma plans to build a vaccine manufacturing facility in Ghana, making the country the first in sub-Saharan Africa to have a dedicated human vaccine manufacturing facility. (fiercepharma.com)
  • We screened a panel of human adenoviruses including Ad5 (species C), Ad26 (species D), Ad35 (species B), Ad48 (species D) and a chimeric Ad5HVR48 for HD5 sensitivity. (prolekare.cz)
  • Delineation of interfaces on human alpha-defensins critical for human adenovirus and human papillomavirus inhibition. (prolekare.cz)
  • 6. Smith JG, Nemerow GR. Mechanism of adenovirus neutralization by Human alpha-defensins. (prolekare.cz)
  • Using cultures of human peripheral blood mononuclear cells (hPBMCs) derived from multiple human donors, we found that Ad5[E1−,E2b−] vaccines trigger higher levels of hPBMC proinflammatory cytokine secretion than Ad5[E1−] vaccines. (asm.org)
  • Ad5-based vaccines are attractive for a multitude of reasons, including their broad human cell tropism, relative ease of manufacturing for scaled production, and low potential for adverse side effects ( 1 ). (asm.org)
  • Although the advantages of these vaccines are abundant, there has been some hesitation toward their practical use due to the high prevalence of preexisting Ad5 immunity in the human population ( 18 - 20 ). (asm.org)
  • Whilst an effective live-attenuated vaccine is available for livestock, there is currently no licensed human RVF vaccine. (biomedcentral.com)
  • Although a highly effective live-attenuated vaccine known as Clone 13 [ 4 ] is available for livestock use in RVF-endemic countries, no licensed livestock vaccines are available for use in RVF-free areas such as Europe and there is currently no licensed human RVF vaccine. (biomedcentral.com)
  • The increasing number and density of the human population, the emergence of lethal influenza strains, and the potential use of designer influenza virus as a bioweapon, collectively highlight a critical need for more rapid production of influenza vaccines and less invasive means of delivery. (nih.gov)
  • We report here that adenovirus-vectored nasal and epicutaneous influenza vaccines were well tolerated by human volunteers. (nih.gov)
  • These results provide the foundation for further human testing of needleless vectored vaccines as promising alternatives to current vaccines. (nih.gov)
  • The Food and Drug Administration has raised the recommended age to receive the vaccine for human papillomavirus, or HPV to 45. (health.mil)
  • The subject of the present invention is defective recombinant adenoviruses, characterized in that they contain a defective, non-replicable adenovirus genome into which one or more nucleic acid sequences coding for one more cytokines, in particular lymphokines, are inserted under the control of one or more promoters capable of being recognised by the polymerases of human cells, more especially of human tumor cells or of cells infiltrating these tumors. (google.com)
  • Herein, we show that a simple dissolvable microneedle array (MA) delivery system preserves the immunogenicity of vaccines encoded by live recombinant human adenovirus type 5 (rAdHu5). (elsevier.com)
  • Like the AstraZeneca and the Johnson & Johnson vaccine, the Sputnik V covid vaccine uses a genetically modified adenovirus to carry genetic instructions into the cells of human recipients. (immunization.news)
  • The adenovirus used in the vaccine is genetically modified and disabled, so it cannot replicate in human tissues. (immunization.news)
  • Once inside human test subjects, the adenovirus can begin replicating, leading to adverse events, sickness and community spread of a new respiratory virus. (immunization.news)
  • [ 141 ] These differences are likely to affect the quality of an antiviral immune response and consequently may lessen the utility of the system for testing vaccines and therapeutics targeting human HCV. (medscape.com)
  • Modification of adenovirus type 5 tropism for a preferential transduction of human papillomavirus-positive cancer cells. (ebscohost.com)
  • Human group C adenoviruses can infect many cell types, and this is due to the widespread expression of their receptor, the coxsackievirus and adenovirus receptor (CAR). (ebscohost.com)
  • The adenovirus vaccine contains viable, selected strains of human adenovirus Type 4 and human adenovirus Type 7 prepared in human-diploid fibroblast cell cultures (strain WI-38). (health.mil)
  • The only adenovirus vaccine used commercially today is a rabies vaccine used to inoculate wild animals. (breastcarenetwork.com)
  • I'm under the impression that adult dogs do not need yearly vaccinations and that rabies vaccines need be given only every three years. (vetinfo.com)
  • State laws require dogs to have current vaccines for specific deadly diseases, such as rabies. (vetinfo.com)
  • Which led me to ask the question: If we are going to be vaccinating people before 2021, which vaccine will it be? (medscape.com)
  • As of March 22, 2021 only 86 potential cases have been reported out of 25 million vaccinated with the AstraZeneca vaccine. (breastcarenetwork.com)
  • [2] A few vaccines also went into use in early 2021. (wikipedia.org)
  • [5] By April 2021, several vaccines were in use around the world and hundreds of millions of people had been vaccinated. (wikipedia.org)
  • World map showing vaccine approval status in 2021. (wikipedia.org)
  • [9] The United States government started Operation Warp Speed to develop a vaccine by January 2021. (wikipedia.org)
  • Urgent investigation into AstraZeneca vaccine after man develops blood clots on April 3, 2021. (thebl.tv)
  • Adenovirus type 4 and type 7 live vaccine is used to prevent febrile (with fever) acute respiratory disease (ARD) caused by adenovirus type 4 and type 7. (mayoclinic.org)
  • Can adenoviruses cause acute respiratory disease? (health.mil)
  • In the United States, acute respiratory disease is often associated with adenovirus Types 4, 7, and 14. (health.mil)