Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses.
Virus diseases caused by the ADENOVIRIDAE.
Species of the genus MASTADENOVIRUS, causing a wide range of diseases in humans. Infections are mostly asymptomatic, but can be associated with diseases of the respiratory, ocular, and gastrointestinal systems. Serotypes (named with Arabic numbers) have been grouped into species designated Human adenovirus A-F.
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
Proteins transcribed from the E1A genome region of ADENOVIRUSES which are involved in positive regulation of transcription of the early genes of host infection.
Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression.
Proteins transcribed from the E4 region of ADENOVIRUSES. The E4 19K protein transactivates transcription of the adenovirus E2F protein and complexes with it.
Proteins encoded by adenoviruses that are synthesized prior to, and in the absence of, viral DNA replication. The proteins are involved in both positive and negative regulation of expression in viral and cellular genes, and also affect the stability of viral mRNA. Some are also involved in oncogenic transformation.
An Ig superfamily transmembrane protein that localizes to junctional complexes that occur between ENDOTHELIAL CELLS and EPTHELIAL CELLS. The protein may play a role in cell-cell adhesion and is the primary site for the attachment of ADENOVIRUSES during infection.
Proteins transcribed from the E3 region of ADENOVIRUSES but not essential for viral replication. The E3 19K protein mediates adenovirus persistence by reducing the expression of class I major histocompatibility complex antigens on the surface of infected cells.
A genus of ADENOVIRIDAE that infects MAMMALS including humans and causes a wide range of diseases. The type species is Human adenovirus C (see ADENOVIRUSES, HUMAN).
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
A genus of ADENOVIRIDAE that infects birds. The type species is FOWL ADENOVIRUS A.
Deoxyribonucleic acid that makes up the genetic material of viruses.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
The very first viral gene products synthesized after cells are infected with adenovirus. The E1 region of the genome has been divided into two major transcriptional units, E1A and E1B, each expressing proteins of the same name (ADENOVIRUS E1A PROTEINS and ADENOVIRUS E1B PROTEINS).
Inflammation of the lung parenchyma that is caused by a viral infection.
Proteins that form the CAPSID of VIRUSES.
Established cell cultures that have the potential to propagate indefinitely.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Inflammation, often mild, of the conjunctiva caused by a variety of viral agents. Conjunctival involvement may be part of a systemic infection.
Species of the genus MASTADENOVIRUS that causes fever, edema, vomiting, and diarrhea in dogs and encephalitis in foxes. Epizootics have also been caused in bears, wolves, coyotes, and skunks. The official species name is Canine adenovirus and it contains two serotypes.
INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.
Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.
A vascular disease of the LIVER characterized by the occurrence of multiple blood-filled CYSTS or cavities. The cysts are lined with ENDOTHELIAL CELLS; the cavities lined with hepatic parenchymal cells (HEPATOCYTES). Peliosis hepatis has been associated with use of anabolic steroids (ANABOLIC AGENTS) and certain drugs.
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
Ribonucleic acid that makes up the genetic material of viruses.
Proteins transcribed from the E2 region of ADENOVIRUSES. Several of these are required for viral DNA replication.
A genus of the family PICORNAVIRIDAE whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated "human enterovirus".
The functional hereditary units of VIRUSES.
The outer protein protective shell of a virus, which protects the viral nucleic acid.
An alpha integrin with a molecular weight of 160-kDa that is found in a variety of cell types. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds. Integrin alphaV can combine with several different beta subunits to form heterodimers that generally bind to RGD sequence-containing extracellular matrix proteins.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.
Proteins found in any species of virus.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
A pyrimidine base that is a fundamental unit of nucleic acids.
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Species of the genus MASTADENOVIRUS, causing neurological disease in pigs.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Compounds consisting of chains of AMINO ACIDS alternating with CARBOXYLIC ACIDS via ester and amide linkages. They are commonly cyclized.
A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
The type species of the genus AVIADENOVIRUS, family ADENOVIRIDAE, an oncogenic virus of birds. This is also called CELO virus for chick embryo lethal orphan virus.
Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Substances elaborated by viruses that have antigenic activity.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, which are dependent on a coinfection with helper adenoviruses or herpesviruses for their efficient replication. The type species is Adeno-associated virus 2.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
The top portion of the pharynx situated posterior to the nose and superior to the SOFT PALATE. The nasopharynx is the posterior extension of the nasal cavities and has a respiratory function.
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
The process by which a DNA molecule is duplicated.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Use of attenuated VIRUSES as ANTINEOPLASTIC AGENTS to selectively kill CANCER cells.
Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Elements of limited time intervals, contributing to particular results or situations.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Simultaneous inflammation of the cornea and conjunctiva.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Disease having a short and relatively severe course.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Vaccines used to prevent infection by any virus from the family ADENOVIRIDAE.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
An abnormal elevation of body temperature, usually as a result of a pathologic process.
The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.
The rate dynamics in chemical or physical systems.
Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. Helper and satellite may be of the same or different genus.
Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-galactosides. Deficiency of beta-Galactosidase A1 may cause GANGLIOSIDOSIS, GM1.

Strain variation in adenovirus serotypes 4 and 7a causing acute respiratory disease. (1/452)

In order to determine the suitability of vaccine strains established in the 1960s for a new vaccine, a comprehensive study of strain variation of adenovirus serotype 4 (AV 4) and AV 7 was undertaken. A 1,500-bp region of the hexon gene containing the AV neutralization epitopes from prototype, vaccine, and community-acquired strains and from wild-type strains from military personnel that cause acute respiratory disease (ARD) was sequenced and analyzed. The whole hexon gene from prototype strains, vaccine strains, and selected isolates was sequenced. AV 7 and AV 7a were found to have distinct genotypes, and all vaccine and wild-type strains recovered from 1963 to 1997 had the AV 7a genotype. There was no significant strain variation in the neutralization epitopes of the AV 7a genotype over a 42-year period. The evolution of AV 4 was more complex, with continuous genetic drift punctuated by replacement with a new strain. The current strain of AV 4, which has been in circulation since 1995, is significantly different from the AV 4 prototype and the vaccine strains. Genetic differences were confirmed to be antigenic differences by neutralization tests, which define the new strain as an AV 4 variant. A type-specific PCR for AV 4, AV 7/7a, and AV 21 was developed, and this PCR facilitated the rapid identification of isolates from outbreaks of ARD.  (+info)

Serotyping of adenoviruses on conjunctival scrapings by PCR and sequence analysis. (2/452)

To detect and identify adenovirus (Ad), we investigated hypervariable regions (HVRs) of Ad by using a combination of PCR and direct sequencing (PCR-sequence) method. Primers for nested PCR to amplify the conserved region in the hexon protein containing HVRs were designed based on hexon gene sequences derived from GenBank. These two primer sets amplified a DNA fragment of 7 HVRs from 16 prototypes of Ad, which were divided into five subgenera, including seven serotypes that are the predominant causative agents of acute conjunctivitis in Japan, and from 31 recent conjunctival scraping specimens from patients with adenoviral conjunctivitis. HVR DNA sequences were determined by means of universal sequence primers. Analysis of the predicted amino acid homology of HVRs among Ad prototypes suggested three regions, HVR4, -5, and -7, to be candidates for the neutralization epitopes. The clinical serotype of specimens was determined by the PCR-sequence method with reference to these three HVRs. The serotype determined according to this method was identical to that obtained by culture isolation and the neutralization test (NT) in all scraping samples, whereas the results of this method did not match PCR and restriction fragment length polymorphism (PCR-RFLP) analysis in five samples. It took only three days to detect Ad and to identify the serotype, in contrast to culture isolation-NT, which took at least 2 weeks. These findings indicate that our newly developed PCR-sequence method is applicable for the detection and serotyping of human Ads.  (+info)

Molecular and serological characterization of adenovirus genome type 7h isolated in Japan. (3/452)

In 1996, three adenovirus type 7 (Ad7) strains were isolated from children with fever and upper respiratory diseases in Japan. Restriction endonucleases (REs) analysis and PCR amplification of the E3 7.7 kDa ORF revealed that these strains were genotype Ad7h and closely related to an Argentine Ad7h strain, which has been reported to be highly virulent and so far predominant only in South America. These strains showed weak cross-neutralizing activity and specific haemagglutination-inhibition activity to Ad3 antiserum. The present findings suggest that Ad7h in South America has spread to other parts of the world. Since the seroprevalence to Ad7 in the current Japanese population is very low due to the absence of Ad7 circulation in Japan for decades, Ad7 outbreak as a typical case of re-emerging infectious diseases is a cause for serious concern.  (+info)

Adenoviruses from human immunodeficiency virus-infected individuals, including two strains that represent new candidate serotypes Ad50 and Ad51 of species B1 and D, respectively. (4/452)

Adenovirus (Ad) isolates from a large number of human immunodeficiency virus (HIV)-infected individuals were compared serologically and genetically with Ad isolates from immunocompetent patients. Between 1982 and 1994, stool and urine samples from 137 subjects with AIDS hospitalized in The Netherlands yielded 143 Ad strains. Forty additional Ad strains were obtained from 35 HIV-positive patients in Manchester, United Kingdom, in 1992 and 1993. Of these 183 HIV-associated Ad strains, 84% belonged to species D and 3% belonged to species C. These strains were compared with 2,301 Ad strains collected during general diagnostic examinations in The Netherlands from 1973 to 1992. Of the latter strains, 5% belonged to species D and 49% belonged to species C. Two of the Ads isolated from fecal specimens of AIDS patients represent new serotypes: candidate Ad serotype 50 (prototype strain, Wan) of subspecies B1 and candidate Ad serotype 51 (prototype strain, Bom) of species D. The DNA restriction enzyme patterns of strains Wan and Bom differed from the patterns of all established prototypes.  (+info)

Adenovirus infections in hematopoietic stem cell transplant recipients. (5/452)

We report a 12% incidence of adenovirus infections among 532 recipients of hematopoietic stem cell transplant (HSCT) from January 1986 through March 1997. The median time from day of stem cell infusion to first positive culture was 41 days. Recipients of allogeneic stem cells, as opposed to autologous stem cell recipients, were more likely to have a culture positive for adenovirus (16% vs. 3%; P<.0001). Pediatric patients were also more likely than adults to have a positive culture (23% vs. 9%; P<.0001). Among stem cell recipients with partially matched related donors, pediatric recipients appear to be at significantly greater risk for infection than adult recipients (P<.001). Positive cultures were associated with evidence of invasion in 64% of cases (41 of 64). A multiple logistic regression analysis showed that isolating adenovirus from more than 1 site correlated with greater risk for invasive infections (P=.002). Invasive infections were associated with poorer chance of survival.  (+info)

Large, persistent epidemic of adenovirus type 4-associated acute respiratory disease in U.S. army trainees. (6/452)

In May 1997, a large, persistent epidemic of adenovirus type 4-associated acute respiratory disease began at Fort Jackson, South Carolina, the largest army basic training center. The epidemic lasted until December and declined when vaccine administration resumed. More than 1,000 male and female trainees were hospitalized; 66.1% of those hospitalized had an adenovirus type 4 isolate.  (+info)

Efficacy of topical cidofovir on multiple adenoviral serotypes in the New Zealand rabbit ocular model. (7/452)

PURPOSE: The goal of the present study was to determine the efficacy of topical 0.5% cidofovir twice daily for 7 days on the replication of multiple adenovirus (Ad) serotypes of subgroup C (Ad1, Ad5, Ad6) in the New Zealand rabbit ocular model. METHODS: In duplicate experiments for each serotype, a total of 20 rabbits (Ad5) or 16 rabbits each (Ad1 and Ad6) were inoculated topically in both eyes, with 1.5 X 10(6) pfu/eye of the appropriate virus. Twenty-four hours later, the rabbits in each serotype group were randomly divided into two topical treatment groups: I, 0.5% cidofovir; II, control vehicle. Treatment was twice daily for 7 days. All eyes were cultured for virus on days 0, 1, 3, 4, 5, 7, 9, 11, and 14. RESULTS: Compared to the control, treatment with 0.5% cidofovir reduced the following: mean Ad titer (days 1 to 7) for Ad1 (6.3 +/- 20 x 10(1) versus 2.5 +/- 3.9 X 102 pfu/ml; P < 0.0003), Ad5 (3.4 +/-5.8 x 102 versus 1.6 +/- 2.0 x 10(3) pfu/ml; P < 0.000001), and Ad6 (1.2 +/- 5.1 x 10(2) versus 5.5 +/-14 x 10(2) pfu/ml; P = 0.015); reduced Ad-positive eyes/total for Adl [45/128 (35%) versus 84/128 (66%); P = 0.000002], Ad5 [84/160 (53%) versus 131/152 (86%); P < 0.000001], and Ad6 [36/128 (28%) versus 82/128 (64%); P < 0.000001]: and reduced the duration of Ad shedding forAdl (4.9 +/-1.9 versus 9.3 +/- 3.3 days; P < 0.00007), Ad5 (6.4 +/- 2.8 versus 11.5 +/- 2.3 days; P < 0.0001), and Ad6 (4.4 +/- 2.1 versus 8.4 +/- 2.5 days; P < 0.00004). CONCLUSIONS: Topical 0.5% cidofovir twice daily for 7 days demonstrated significant antiviral activity against multiple adenoviral serotypes (Ad1, Ad5, and Ad6) in the New Zealand rabbit ocular model. These in vivo data expand in vitro studies indicating the efficacy of cidofovir against different adenovirus serotypes and support its use in clinical trials.  (+info)

Molecular epidemiology of ocular isolates of adenovirus 8 obtained over nine years. (8/452)

Twenty nine strains of adenovirus 8 have been isolated over nine years in Strasbourg, France, 22 of which were from one private ophthalmologist. To assess a possible relation between these strains, the DNA of adenovirus was analysed by restriction fragment length polymorphism using eight different enzymes. Among these, three proved discriminant (Xba I, Bgl II, Eco RI) and made it possible to define 13 genotypes differing from each other by one to three DNA bands. Seven genotypes were unique isolates, while three, representing 16 strains, were isolated over five to eight years. All the genotypes but one were closely related, with 87% homology. All 13 differed from an adenovirus 8 strain from Lyon (homology 68-76%). This study confirmed the stability of adenovirus 8 in a given population.  (+info)

Adenoviruses are the most common cause of acute viral infections of the conjunctiva, occurring epidemically or sporadically throughout all seasons. Clinically, 4 syndromes of adenoviral ocular infection have been recognized, as follows: epidemic keratoconjunctivitis, pharyngoconjunctival fever (PCF), nonspecific sporadic follicular conjunctiv...
86 PCR positive samples were inoculated onto Hep-2 cell for virus isolation, and 23 HAdV strains were isolated through 7-21 days post-inoculation, with isolation rate of 26.74%, which was close to that of 21.43% in the previous study (Thounaojam et al. 2016). The hexon gene sequence has widely been used for the classification of adenovirus types. In this study, the hexon gene of the 23 HAdV isolates was amplified and sequenced using primer designed by Sarantis et al. (Sarantis et al. 2004) (Forward primer: 5′-CTGATGTACTACAACAGCACTGGCAACATGGG-3′, Reverse primer: 5′-GCGTTGCGGTGGTGGTTAAATGGGTTTACGTTGTCCAT-3′, the amplicon length is 580-605 bp), and the nucleotide sequences were submitted to GenBank (accession numbers MN389388-MN389410). Molecular typing assignments were based on the identity of the closest matching sequences after both BLAST and phylogenetic analysis. Results showed that 9 of the 23 HAdV isolates (8 HAdV-3 and 1 HAdV-7) belonged to species B and 12 of the 23 (5 HAdV-1 and 7 ...
Doctors Ask: Adenovirus infection is exposed to all segments of the population. Basic manifestations of adenovirus infection The latent (incubation period) is usually 5-7 days. The disease most often begins acutely, from the phenomena of intoxication: slight increase in temperature, rashes in the body, chills, lethargy, headache, loss of appetite, etc.
Adenovirus infection generally may lead to common cold, pneumonia and pharyngitis.There are few types of adenoviruses. Specifically, adenoviruses types 8,19 and 37 will lead to keratoconjunctivitis mostly in adult.
In one mode of adenovirus infection (called lytic infection because it destroys large numbers of cells), adenoviruses kill healthy cells and replicate up to 1 million new viruses per cell killed, of which 1 to 5 percent are infectious. People with this kind of infection feel sick. In chronic or latent infection, a much smaller number of viruses are released, and healthy cells can multiply more rapidly than they are destroyed. People who have this kind of infection do not exhibit symptoms. Children who have normal immune systems usually experience only minor symptoms when infected with adenovirus. The course of infection tends to be more serious in children who are immunocompromised, such as those undergoing chemotherapy or those who have a disease that disrupts normal immune response (e.g. human immunodeficiency syndrome [HIV]). In such children, the virus more often affects organs such as the lungs, liver, and kidneys, and the risk of fatality increases. Symptoms common to respiratory illnesses ...
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Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States in association with outbreaks of acute respiratory disease with high rates of illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009-July 31, 2010, and describe 9 cases of HAdV-14p1 infection with characteristic mutations in the fiber and E1A genes that are phylogenetically indistinguishable from the viruses previously detected in the United States. Three patients died; 2 were immunocompromised, and 1 was an immunocompetent adult. We propose that surveillance should be increased for HAdV-14p1 and recommend that this virus be considered in the differential diagnosis of sudden-onset acute respiratory disease, particularly fatal infections, for which an etiology is not clear.
TY - JOUR. T1 - Survey of infectious agents involved in acute respiratory disease in finishing pigs. AU - Loeffen, W.L.A.. AU - Kamp, E.M.. AU - Stockhofe-Zurwieden, N.. AU - van Nieuwstadt, A.P.K.M.I.. AU - Bongers, J.H.. AU - Hunneman, W.A.. AU - Elbers, A.R.W.. AU - Baars, J.. AU - Nell, T.. AU - van Zijderveld, F.G.. PY - 1999. Y1 - 1999. U2 - 10.1136/vr.145.5.123. DO - 10.1136/vr.145.5.123. M3 - Article. VL - 145. SP - 123. EP - 129. JO - Veterinary Record. JF - Veterinary Record. SN - 0042-4900. IS - 5. ER - ...
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Get this from a library! Acute respiratory diseases: symposium organized by the College of Pathologists and delivered in London in February 1968;. [D A J Tyrrell; College of Pathologists.;]
The inner-city infants had lower rates of viral detection overall. This may suggest that other factors, such as bacteria or allergic reactions to air pollutions or toxic exposures, contribute significantly to respiratory illness. Sick urban infants had lower rates of two kinds of viruses, HRV and RSV, and higher rates of adenovirus infections, compared to suburban infants. In the urban babies, 4.8 percent of nasal washes tested positive for only adenovirus, while just 0.7 percent of samples from suburban babies were positive for only adenovirus. Adenovirus infections, either as a single pathogen or when detected in concert with other viruses, were significantly more common in the urban population, and this held true for each of the four urban locations where our study was conducted, the authors wrote ...
My son has this virus. He has pink eye in both eyes, the sore throat, ear infection, he had a fever for 3 days, diarrhea and he has said when he watches Tv its like the tv is spinning. He gets sick so fast that he has had just about every virus out there. So far this particular virus is lasting all most a week now. I cant wait till its completely gone. He has already been out of school for 4 days.... ...
Ann Treacy, Michael J. Carr, Linda Dunford, Gustavo Palacios, Gemma A. Cannon, Anthony OGrady, Julie Moran, Jaythoon Hassan, Aisling Loy, Jeff Connell, Deirdre Devaney, Peter Kelehan, William W. Hall ...
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Signs and Symptoms The two frequently encountered forms of viral conjunctivitis are pharyngoconjunctival fever (PCF) and epidemic keratoconjunctivitis (EKC).1-11 Pharyngoconjunctival fever is characterized by a fever, sore throat, history of recent upper respiratory infection (URI) and follicular conjunctivitis.1,2,4,7,9-11 The condition may be unilateral or bilateral, but classically presents in one eye and is spread to…. Read More ...
TY - JOUR. T1 - Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients. AU - Muller, William J.. AU - Levin, Myron J.. AU - Shin, Young Kyoo. AU - Robinson, Christine. AU - Quinones, Ralph. AU - Malcolm, Janet. AU - Hild, Elaine. AU - Gao, Dexiang. AU - Giller, Roger. PY - 2005/12/15. Y1 - 2005/12/15. N2 - Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT patients, 18 of whom had severe manifestations of infection. Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 patients. In vitro susceptibility to cidofovir was demonstrated in 12 clinical adenovirus isolates. Cidofovir is a promising treatment option for this population.. AB - Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT ...
Background Human Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. They particularly cause frequent morbidity among children. In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited st...
Albinana-Gimenez N., M.P. Miagostovich, B. Calgua, J.M. Huguet, L. Matia and R. Girones. 2009. Analysis of adenoviruses and polyomaviruses quantified by qPCR as indicators of water quality in source and drinking-water treatment plants. Water Res. 43:2011-2019. [PubMed]. Barrella K.M., P. Garrafa, T.A. Monezi, C.M. Harsi, C. Salvi, P.A. Violante and D.U. Mehnert. 2009. Longitudinal study on occurrence of adenoviruses and hepatitis A virus in raw domestic sewage in the city of Limeira, Sao Paulo. Braz. J. Microbiol. 40:102-107. [PubMed]. Bibby K. and J. Peccia. 2013. Prevalence of respiratory adenovirus species B and C in sewage sludge. Environ. Sci. Process Impacts. 15(2):336-8 [PubMed]. Cantalupo P.G, B. Calgua, G. Zhao, A. Hundesa, A.D. Wier, J.P. Katz, M. Grabe, R.W. Hendrix, R. Girones, D. Wang and others. 2011. Raw sewage harbors diverse viral populations. MBio. 2(5):e00180-11 [PubMed]. Cruz J.R., P. Caceres, F. Cano, J. Flores, A. Bartlett and B. Torun. 1990. Adenovirus types 40 and 41 and ...
TY - JOUR. T1 - Safety and Efficacy of CMX001 as Salvage Therapy for Severe Adenovirus Infections in Immunocompromised Patients. AU - Florescu, Diana F.. AU - Pergam, Steven A.. AU - Neely, Michael N.. AU - Qiu, Fang. AU - Johnston, Christine. AU - Way, SingSing. AU - Sande, Jane. AU - Lewinsohn, Deborah. AU - Guzman-Cottrill, Judith. AU - Graham, Michael L.. AU - Papanicolaou, Genovefa. AU - Kurtzberg, Joanne. AU - Rigdon, Joseph. AU - Painter, Wendy. AU - Mommeja-Marin, Herve. AU - Lanier, Randall. AU - Anderson, Maggie. AU - van der Horst, Charles. PY - 2012/5. Y1 - 2012/5. N2 - No therapeutic agent has yet been established as the definitive therapy for adenovirus infections. We describe the clinical experience of 13 immunocompromised patients who received CMX001 (hexadecyloxypropyl cidofovir), an orally bioavailable lipid conjugate of cidofovir, for adenovirus disease. We retrospectively analyzed 13 patients with adenovirus disease and viremia treated with CMX001; data were available for ...
Background. Military recruits are at a higher risk of respiratory infection than their civilian counterparts. Continuous outbreaks of adenovirus (Ad)â€associated acute respiratory disease were documented among US trainees before the implementation of serotype 4 (Ad4) and serotype 7 vaccines in 1971. The discontinuation of Ad vaccination programs in 1999 precipitated the reemergence of Ad in training sites, with Ad4 accounting for 98% of all diagnosed cases. Methods. A total of 724 Ad4 strains isolated from recruits presenting with febrile respiratory illness at 8 training sites nationwide between 1997 and 2003 were genome typed by restriction enzyme analysis. Results. Seven genome types were identified, all of which were distinct from the prototype Ad4p and the vaccine type 4p1. Results showed very different, and often stable, genome type distributions at different geographic sites, despite the homogeneity of the recruit source population. Conclusions. The data support the hypothesis that ...
Learn about the programs and services for Adenovirus Infections at Boston Childrens, ranked best Childrens Hospital by US News.
Vectors derived from human adenovirus type 5, which typically lack the E1A and E1B genes, induce robust innate immune responses that limit their therapeutic efficacy. mutant-infected cells in the absence or presence of exogenous IFN. Both the concentration of viral genomes detected during the late phase and the numbers of viral replication centers formed were strongly reduced in IFN-treated cells in the absence of the E1B protein, despite production of similar quantities of viral replication proteins. These defects could not be attributed to degradation of entering viral genomes, induction of apoptosis, or failure to reorganize components of PML nuclear bodies. Nor was assembly of Nutlin 3a the E1B- and E4 Orf6 protein- E3 ubiquitin ligase required to prevent inhibition of viral replication by IFN. However, by using RT-PCR, the E1B 55 kDa protein was demonstrated to be a potent repressor of expression of IFN-inducible genes in IFN-treated cells. We propose that a primary function of the ...
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Enteric viruses transmitted via the faecal-oral route occur in high concentrations in wastewater and may contaminate drinking water sources and cause disease. In order to quantify enteric adenovirus...
Adenoviral nucleic acid was detected by polymerase chain reaction (PCR) in pharyngeal and rectal swab samples of a cat seropositive for adenovirus and suffering from transient hepatic failure. The samples were taken at a one-year interval, and both faecal samples as well as the second pharyngeal sample were positive in ... read more PCR performed with general adenovirus primers. The size of the amplified products corresponded to that of the positive control. The identity of the amplicons was also confirmed by DNA sequencing. The 301 bp long hexon gene fragment was very similar to but distinguishable from the corresponding hexon sequence of human adenovirus type 2. This result suggests the possibility of persistent carrier status and shedding of adenovirus in cats. show less ...
Human adenovirus (HAdV) is a common pathogen causing a broad spectrum of diseases. HAdV encodes the pVII protein, which is involved in nuclear delivery, protection and expression of viral DNA. To suppress the cellular interferon (IFN) and RNA interference (RNAi) systems, HAdVs encode non-coding virus-associated (VA) RNAs. In this thesis we have investigated the functional significance of the pVII protein and VA RNAI in HAdV-5 infected cells.. We report that the propeptide module is the destabilizing element targeting the precursor pVII protein for proteasomal degradation. We also found that the Cul3-based E3 ubiquitin ligase complex alter the precursor pVII protein stability via binding to the propeptide sequence. In addition, we show that inhibition of the Cul3 protein reduces HAdV-5 E1A gene expression. Collectively, our results suggest a novel function for the pVII propeptide module and involvement of Cul3 in viral E1A gene expression.. Our studies show that the cellular E3 ubiquitin ligase ...
Human adenovirus 12 ATCC ® VR-863D™ Designation: DNA from Human adenovirus 12 strain Huie [ATCC ® VR-863™] Application: It is suitable for use in polymerase chain reaction (PCR) for viral gene products and other molecular virology applications. Respiratory research
Human adenovirus 4 ATCC ® VR-1572D™ Designation: DNA from Human adenovirus 4 strain RI-67 [ATCC ® VR-1572™] Application: It is suitable for use in polymerase chain reaction (PCR) for viral gene products and other molecular virology applications. Respiratory research
Adenoviruses (HAdV) can cause serious life threatening infections, especially in pediatric patients after allogeneic stem cell transplantation (SCT). To improve the morbidity and mortality rate of HAdV infected patients after SCT three issues have been explored: which patients are at risk for HAdV infection, what is the best treatment for ... read more HAdV infected patients and when do we start treatment. We found that in pediatric patients HAdV-DNA positivity in nasopharyngeal aspirate before SCT is a very important risk factor for developing invasive HAdV infection after SCT. As determined with multiplex immuno-assay we also found that children with a localized HAdV infection have a different cytokine profile compared with patients with an invasive HAdV infection after SCT. Cytokine signatures can also be helpful to differentiate invasive HAdV infection from other SCT related complications as Graft versus Host Disease (GvHD) and Epstein-barr virus infection. Immune profiling could possibly ...
We identified previously unrecognized variations in the fiber gene and E4 ORF 6/7 peptides among the various genome types of Ad7. In particular, multiple amino acid changes at E4 ORF 6/7 peptides showed genome type-specific differences between Ad7d and a novel genome type Ad7l. However, no genetic divergence was identified in the hexon gene or in E3 peptides among the 12 Korean strains of Ad7. This result indicates that the nucleotide structures of the fiber gene and of E4 ORF 6/7 peptides might have contributed to the genetic heterogeneity during the Ad7 epidemics in Korea, whereas those of the hexon gene and E3 were highly conserved.. So far, the fiber gene and E4 have rarely been addressed with regard to the evolution and molecular epidemiology of Ad7 strains (17). Restriction analysis of genomic DNA has been the most popular method of describing the molecular epidemiology of the adenoviruses (18). However, little is known about sequence variations with regard to the genome type within an ...
Adenovirus has been associated with both sporadic and epidemic disease and, with regard to infections among military recruits, who were routinely immunized against types 4 and 7 from 1971 until the cessation of vaccine production in 1996. Adenovirus became a significant cause of economic cost and morbidity in this setting. A live oral vaccine against adenovirus types 4 and 7 was approved for use in this population by the US Food and Drug Administration (FDA) in 2011, and subsequent incidence of acute respiratory disease declined.. Of interest is the role of adenoviruses as vectors in vaccination and in gene therapy. [1, 2, 3] Adenoviruses can infect various cells, both proliferating and quiescent, and thus hold the promise of targeting many different tissues and diseased cell lines.. The genome of adenovirus is well known and can be modified with relative ease to induce lysis or cytotoxicity of a specified cell line without affecting others.. The virus itself can be engineered to remove its ...
DNA restriction analysis was carried out on a sample of 212 epidemiologically unrelated adenovirus (Ad) strains of serotype 7 isolated in Chile, Uruguay, and Argentina from nasopharyngeal aspirates of children with acute lower respiratory disease between 1984 and 1990. The identified genome types were Ad7b (n = 12), Ad7c (n = 21), and Ad7h (n = 179). The analysis of the occurrence of the three genome types throughout the study period revealed that Ad7c was the predominant virulent variant in 1984 and indicated that a shift to genome type 7h took place in 1986. Ad7b cocirculated with the other genomic variants at a relatively low frequence. ...
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NEW YORK (GenomeWeb News) - Researchers from China and the US will sequence 100 human adenoviruses, including ones that cause respiratory, gastrointestinal, and ocular diseases, under a partnership announced today.
Feucht, Judith; Opherk, Kathrin; Lang, Peter; Kayser, Simone; Hartl, Lena; Bethge, Wolfgang; Matthes-Martin, Susanne; Bader, Peter; Albert, Michael H.; Maecker-Kolhoff, Britta; Greil, Johann; Einsele, Hermann; Schlegel, Paul-Gerhardt; Schuster, Friedhelm R.; Kremens, Bernhard; Rossig, Claudia; Gruhn, Bernd; Handgretinger, Rupert; Feuchtinger, Tobias ...
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There are many stages in the development of a new drug for viral infection and such processes are even further complicated for adenovirus by the fact that there are at least 51 serotypes, forming six distinct groups (A-F), with different degree of infectivity. This review attempts to address the importance of developing pharmaceuticals for adenovirus and also review recent development in drug discovery for adenovirus, including newer strategies such as microRNA approaches. Different drug screening strategies will also be discussed.
Adenovirus Type 9, 0.1 mg. The many different serotypes of human adenoviruses (Ad) are divided into six subgroups, of which all Ad subgroup A and B and two subgroup D Ads can elicit tumors in infected rodents.
This post is about adenovirus infection, a major cause of illness both minor and severe in the United States, especially among children in group settings.
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-Maintains strong financial position with $314.5 million in capital at quarter end-. DURHAM, N.C., May 09, 2016-- Chimerix, a biopharmaceutical company developing novel antivirals to address unmet medical needs, today reported top-line results from an interim analysis of the AdVise trial of brincidofovir for serious adenovirus infection and other corporate...
Define epidemic keratoconjunctivitis. epidemic keratoconjunctivitis synonyms, epidemic keratoconjunctivitis pronunciation, epidemic keratoconjunctivitis translation, English dictionary definition of epidemic keratoconjunctivitis. n. Inflammation of the cornea and conjunctiva. Noun 1. keratoconjunctivitis - inflammation of the cornea and conjunctiva inflammation, redness, rubor - a...
TY - JOUR. T1 - Adenovirus infections in heart transplantation. AU - Florescu, Diana F.. AU - Kwon, Joong Y.. AU - Dumitru, Ioana. PY - 2013/7. Y1 - 2013/7. N2 - Adenovirus infections have been associated with significant morbidity and mortality in immunocompromised hosts. The clinical significance of adenovirus disease in heart transplantation is not well-defined; in particular, the significance of adenovirus identification in myocardium remains unclear. Although severe adenovirus disease has been described in heart transplant recipients, adenovirus infections seem to be more frequently associated with increased risk of adverse cardiac events, such as rejection, ventricular dysfunction, coronary vasculopathy, need for retransplantation, and graft loss because of death. Cidofovir is currently considered the standard of treatment for adenovirus disease not responding to reduction of immunosuppression.. AB - Adenovirus infections have been associated with significant morbidity and mortality in ...
We determined the complete genome sequence of epidemic keratoconjunctivitis (EKC)-related human adenoviruses (HAdVs). We analysed a total of 12 HAdV strains; three prototype strains and two HAdV-8, three HAdV-19 and three HAdV-37 clinical isolates from EKC patients in Japan, and one novel serotype of HAdV. Genome organization of these serotypes was identical to those of the recently determined HAdV-19 and HAdV-37. The identities of the whole genome were over 99 % among strains from the same serotype, except for HAdV-19p, which is not associated with conjunctivitis, resulting in the formation of a distinct cluster in the phylogenetic analysis. The penton, loop 1 and loop 2 of hexon, early region 3 (E3) and fiber were hypervariable regions between serotypes. Results suggest that the HAdV-19 clinical strain is a recombinant of HAdV-19p-like and HAdV-37-like strains, and that the acquisition of the penton, E3 or fiber may be related to ocular tropism.
Gene probes developed locally for both enteric Adenoviruses 40 and 41 were used to determine whether these viruses were present in both raw and treated waters. Approximately sixty water samples were concentrated by ultra filtration and analysed directly for the presence of enteric adenoviruses. Three pre-treatment techniques, namely sephadex columns, cellulose fibre and Geneclean(TM) were tested for the removal of inhibitory substances from concentrated water samples. The effect of chlorine treatment on viral detection using gene probe hybridization was also examined by exposing adenoviruses to chlorine concentrations of up to 20mg/l for 1 hour. Enteric adenoviruses were detected in up to 59% of both raw and treated waters analysed, Cellulose fibre and Geneclean(TM) were found to successfully remove inhibitory substances from concentrated raw waters. Viral I NA was detected after exposure to a range of chlorine concentrations indicating that the viruses detected in the treated waters may have ...
Adenovirus type 37 (Ad37) is a leading cause of epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular disease. Whereas most other adenoviruses infect cells by engaging CD46 or the coxsackie and adenovirus receptor (CAR), Ad37 binds previously unknown sialic acid-containing cell surface molecules. By glycan array screening, we show here that the receptor-recognizing knob domain of the Ad37 fiber protein specifically binds a branched hexasaccharide that is present in the GD1a ganglioside and that features two terminal sialic acids. Soluble GD1a glycan and GD1a-binding antibodies efficiently prevented Ad37 virions from binding and infecting corneal cells. Unexpectedly, the receptor is constituted by one or more glycoproteins containing the GD1a glycan motif rather than the ganglioside itself, as shown by binding, infection and flow cytometry experiments. Molecular modeling, nuclear magnetic resonance and X-ray crystallography reveal that the two terminal sialic acids dock into two of
In 2005, a human adenovirus strain (formerly known as HAdV-D22/H8 but renamed here HAdV-D53) was isolated from an outbreak of epidemic keratoconjunctititis (EKC), a disease that is usually caused by HAdV-D8, -D19, or -D37, not HAdV-D22. To date, a complete change of tropism compared to the prototype has never been observed, although apparent recombinant strains of other viruses from species Human adenovirus D (HAdV-D) have been described. The complete genome of HAdV-D53 was sequenced to elucidate recombination events that lead to the emergence of a viable and highly virulent virus with a modified tropism. Bioinformatic and phylogenetic analyses of this genome demonstrate that this adenovirus is a recombinant of HAdV-D8 (including the fiber gene encoding the primary cellular receptor binding site), HAdV-D22, (the ε determinant of the hexon gene), HAdV-D37 (including the penton base gene encoding the secondary cellular receptor binding site), and at least one unknown or unsequenced HAdV-D strain.
In 2005, a human adenovirus strain (formerly known as HAdV-D22/H8 but renamed here HAdV-D53) was isolated from an outbreak of epidemic keratoconjunctititis (EKC), a disease that is usually caused by HAdV-D8, -D19, or -D37, not HAdV-D22. To date, a complete change of tropism compared to the prototype has never been observed, although apparent recombinant strains of other viruses from species Human adenovirus D (HAdV-D) have been described. The complete genome of HAdV-D53 was sequenced to elucidate recombination events that lead to the emergence of a viable and highly virulent virus with a modified tropism. Bioinformatic and phylogenetic analyses of this genome demonstrate that this adenovirus is a recombinant of HAdV-D8 (including the fiber gene encoding the primary cellular receptor binding site), HAdV-D22, (the ε determinant of the hexon gene), HAdV-D37 (including the penton base gene encoding the secondary cellular receptor binding site), and at least one unknown or unsequenced HAdV-D strain.
Human adenovirus, of the Adenoviridae family, is a nonenveloped icosahedral particle containing a single linear dsDNA genome. Human adenovirus comprises 6 species (A through F) consisting of serotypes 1 - 51, and associated with a variety of clinical illnesses. Serotypes 1-39, 42-51 are associated with a variety of respiratory disease, generally in children and immunocompromised persons; whereas serotypes 40 and 41 is associated with enteric disease (enteric adenovirus) particularly in children - these enteric adenoviruses will not be detected with the assay described here. Serotypes 12, 18, 31 have a high oncogenic potential and serotypes 4 and 7 are associated with acute respiratory disease (ARD) frequently in military recruits and typically occur in the winter and spring. Smaller outbreaks of serotypes 3, 4, and 7 occur in the summertime and are associated with contaminated swimming pool water.. Adenovirus infections of the eye may lead to pharyngo-conjunctival fever, follicular ...
I had Epidemic Keratoconjunctivitis 2.5years ago and still have scarring on my cornea, intense glare sensitivity and am still wearing glasses for every day use (I never wore them before the infection)....
Human adenoviruses (HAdVs) cause a wide range of diseases worldwide, including respiratory infections. Studies on HAdV molecular epidemiology are limited in Cameroon. The purpose of this study is to document the different types HAdV circulating in Cameroon in children with acute respiratory infections. Nasopharyngeal swabs were collected from 811 children under 15 years from 2011 to 2014. The HAdV detection was assessed by semi-quantitative generic PCR r-gene®. The HAdV-positive samples were typed by amplification and sequencing of partial hexon gene and a real-time PCR. Demographic data were collected and analyzed. The infection and hospitalization risk factors were assessed thought the Chi-square test. A total of 137/220 HAdV-positive samples were amplified successfully. Six species of HAdV (Mastadenovirus A to F) were detected with B (108/220) and C (47/220) being the predominant strains. Hospitalization and age were significantly associated to HAdV-B and HAdV-C respectively. Phylogenetic analysis
Seventy-eight cases were identified in patients from four eye care practices, two family practices, and the hospital emergency department. The median patient age was 45 years (range = 9 months-90 years), and 33 (42%) were men. Ocular signs and symptoms included redness (68%), watery discharge (50%), and pain (29%). Severe signs included corneal infiltrates (17%) and pseudomembranes (6%). At least 12 cases (15%) were health care-associated (Figure). One health care-associated case occurred in a health care worker. Seventeen patients whose infections were not health care-associated reported a symptomatic household or community contact. Among 45 conjunctival swabs available for testing, 19 (42%) were positive for HAdV-8. Genome sequences obtained from five HAdV-8 isolates were 100% identical with one another and showed 97.7% (accession number AB861610.1) to 99.9% (accession number KT340070.1) nucleotide sequence similarity to other HAdV-8 genome sequences available in GenBank, the National ...
To define the bottlenecks that restrict antigen expression after oral administration of viral-vectored vaccines, we tracked vectors derived from the human adenovirus type 5 at whole body, tissue and cellular scales throughout the digestive tract in a murine model of oral delivery. After intragastric administration of vectors encoding firefly luciferase or a model antigen, detectable levels of transgene-encoded protein or mRNA were confined to the intestine, and restricted to delimited anatomical zones. Expression of luciferase in the form of multiple small bioluminescent foci in the distal ileum, cecum and proximal colon suggested multiple crossing points. Many foci were unassociated with visible Peyers patches, implying that transduced cells lay in proximity to villous rather than follicle-associated epithelium, as supported by detection of transgene-encoded antigen in villous epithelial cells. Transgene-encoded mRNA but not protein was readily detected in Peyers patches, suggesting that post
It has been known for some time that the human adenovirus serotype 5 (Ad5) E4orf6 and Sox18 E1B55K proteins work in concert to degrade p53 and to regulate selective export of late viral mRNAs during productive infection. H1299 human lung carcinoma cells after expression of E1B55K and E4orf6 using adenovirus vectors. Several species were detected and identified by mass spectroscopy and for one of these integrin α3 we went on in a parallel study to confirm it as a substrate of the complex (F. Dallaire et al. J. Virol. 83:5329-5338 2009 Although the system has some limitations it may still be of some general use in identifying candidate substrates of any viral cullin-based E3 ubiquitin ligase complex and we suggest a series of criteria for substrate validation. During the past decade protein degradation has become increasingly recognized SVT-40776 (Tarafenacin) as a critical mechanism by which cells regulate a number of fundamental processes (reviewed in references 37 57 and 59). Degradation ...
The interaction between clinicians and patients produces a dynamic that can affect both and forms a part of the risk associated with medical practice. The clinician can sometimes become the main agent for the spread of disease by omissions, which usually do not affect the medical personnel or the patients. However, under certain circumstances, members of the medical workforce can become risks for their own health and that of their patients by becoming a vector for disease transmission. In this study, we report on an outbreak of conjunctivitis involving both clinicians and patients. Human adenovirus (Ad) belongs to a family comprising about 100 members that are grouped into six subgenera (A-F) based on several biochemical and molecular criteria. Fifty-one Ad types have been identified as human pathogens, some of which are able to survive under adverse conditions outside of the human body [1,2]. A typical Ad infection includes a 5-12 day incubation period before the onset of symptoms followed by a ...
Recombinant adenoviruses currently are used for a variety of purposes, including gene transfer in vitro, vaccination in vivo, and gene therapy (1-4). Several features of adenovirus biology have made such viruses the vectors of choice for certain of these applications. For example, adenoviruses transfer genes to a broad spectrum of cell types, and gene transfer is not dependent on active cell division. Additionally, high titers of viruses and high levels of transgene expression generally can be obtained.. Decades of study of adenovirus biology have resulted in a detailed picture of the viral life cycle and the functions of the majority of viral proteins (5, 6). The genome of the most commonly used human adenovirus (serotype 5) consists of a linear, 36-kb, double-stranded DNA molecule. Both strands are transcribed and nearly all transcripts are heavily spliced. Viral transcription units are conventionally referred to as early (E1, E2, E3, and E4) and late, depending on their temporal expression ...
Adenoviruses (HAdVs) are nonenveloped lytic DNA viruses with 67 different human serotypes. HAdV infection post transplant seems to be caused by endogenous viral reactivation in most cases....
Mouse anti Adenovirus Hexon antibody, clone 7C11 reacts with human, canine, bovine, monkey and rat adenoviruses. It is very likely that it
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Adenovirus and pregnancy - What is adenovirus infection? Many forms. This virus can produce several forms of infection. Pharyngo-conjunctival fever (or swimming pool fever) is one of the better known, but also gastroenteritis, upper respiratory tract infections and pneumonia can all occur.
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Human adenoviruses (HAdVs) often cause mild respiratory infections. These infections, however, can potentially become fatal in immunosuppressive patients. Unfortunately, there has been no specific anti-HAdV drug approved for treatment of HAdV infections. In this study, a time-course transcriptome of HAdV-infected human lung epithelial cells (A549 cells) was performed and compared with perturbation datasets of 890 drug-treated A549 cells from the library of integrated network-based cellular signatures (LINCS) database to predict previously unknown therapeutic drug-HAdV relationships using a characteristic direction (CD) algorithm. We performed experiments to validate a prediction for the anti-diabetic drug rosiglitazone as a candidate drug for treatment of anti-HAdV both in vivo and in vitro. The Type I interferon (IFNs) signaling pathway was negatively regulated during the course of HAdV infection and rosiglitazone increased STAT1 phosphorylation for antiviral IFN response induction. Taken ...
Fingerprint Dive into the research topics of Accumulation of early and intermediate mRNA species during subgroup C adenovirus productive infections. Together they form a unique fingerprint. ...
13:2; potential epub Adenovirus notions; tenure bhakti 1? On the epub Adenovirus Methods and of this interest, are above under form. 1282 An epub Adenovirus Methods and Protocols: Adenoviruses, Ad study read by Porten - Szubin 1987:187.
Scientists are reporting discovery of a potential new drug for epidemic keratoconjunctivitis (EKC) -- sometimes called pink eye -- a highly infectious eye disease that may occur in 15 million to 20 million people annually ...
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Fingerprint Dive into the research topics of Two early mRNA species in adenovirus type 2 transformed rat cells. Together they form a unique fingerprint. ...
1NLN: Crystallographic structure at 1.6-A resolution of the human adenovirus proteinase in a covalent complex with its 11-amino-acid peptide cofactor: insights on a new fold
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Medical Virology 8 Luis M De La Maza Ellena M Peterson No Preview Available 2014 Medical Virology 8 Luis M De La Maza Ellena M Peterson No Preview Available 2013 View All Common Terms And Phrases Acad Sci Usa Activity Adenovirus Antigen Antipeptide Antibodies Antiviral Assay Binding Blood Cell Lines Cell Surface Cellular Chronic Class I Antigens Clinical Coxsackievirus Culture
Detect adenovirus rescue even before cytopathic effect (CPE) is observed. Ensure high titer by harvesting amplified adenovirus at the optimal time
... implication for adenovirus-mediated gene therapy". Human Gene Therapy. 10 (6): 957-64. doi:10.1089/10430349950018355. PMID ... June 1999). "Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands". Infection and Immunity ... "Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin". The Journal of ... Hiratsuka T, Nakazato M, Ashitani J, Matsukura S (February 1999). "[A study of human beta-defensin-1 and human beta-defensin-2 ...
... also participates in ATR protein kinase signalling pathways during adenovirus infection. Two transcript variants ... 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi: ... 2005). "Protein arginine methylation during lytic adenovirus infection". Biochem. J. 383 (Pt 2): 259-65. doi:10.1042/BJ20040210 ... Heterogeneous nuclear ribonucleoprotein U-like protein 1 is a protein that in humans is encoded by the HNRNPUL1 gene. This gene ...
HumansEdit. Main article: Adenovirus infection. Humans infected with adenoviruses display a wide range of responses, from no ... InfectionsEdit. Main article: Adenovirus infection. Most infections with adenovirus result in infections of the upper ... In humans, there are 57 accepted human adenovirus types (HAdV-1 to 57) in seven species (Human adenovirus A to G):[3] ... Adenoviruses are also known to cause respiratory infections in horses, cattle, pigs, sheep, and goats. Equine adenovirus 1 can ...
"Serologic Evidence for Human Infection with Adenovirus-Associated Viruses". JNCI: Journal of the National Cancer Institute. ... He was a pioneer in research on adenoviruses and their role in human diseases. The discoveries of adenoviruses by Rowe et al. ( ... Huebner, R. J.; Rowe, W. P.; Lane, W. T. (1962). "Oncogenic Effects in Hamsters of Human Adenovirus Types 12 and 18". ... Hoggan, M. D.; Blacklow, N. R.; Rowe, W. P. (1966). "Studies of small DNA viruses found in various adenovirus preparations: ...
The viruses thought to be involved include the adenovirus, which causes respiratory infections; the human parvovirus B19, an ... infection that affects children; and the human parainfluenza virus. Some sufferers attribute the onset of PMR to stress.[ ... CRP is produced by the liver in response to an injury or infection, and people with polymyalgia rheumatica usually have high ... citation needed] Persons having the HLA-DR4 type of human leucocyte antigen appear to have a higher risk of PMR. No specific ...
HSP is often preceded by an infection, such as a throat infection. HSP is a systemic vasculitis (inflammation of blood vessels ... The genetic basis remains unclear except for involvement of the human leukocyte antigen region of the genome. It is ... hypothesized to involve autoimmunity triggered by infections, particularly Staphylococcus aureus, Mycoplasma and adenovirus.[ ... HSP can develop after infections with streptococci (β-haemolytic, Lancefield group A), hepatitis B, herpes simplex virus, ...
Infection by human adenovirus accounts for 65% to 90% of cases of viral conjunctivitis.[13] ... "Molecular epidemiology of circulating human adenovirus types in acute conjunctivitis cases in Chandigarh, North India". Indian ... An adenovirus was first isolated by Rowe et al. in 1953. Two years later, Jawetz et al. published on epidemic ... Vaccination against adenovirus, Haemophilus influenzae, pneumococcus, and Neisseria meningitidis is also effective.[27] ...
Viral causes include human respiratory syncytial virus (RSV), human metapneumovirus, adenovirus, human parainfluenza viruses, ... The symptoms of CAP are the result of lung infection by microorganisms and the response of the immune system to the infection. ... Viral infections weaken the immune system, making the body more susceptible to bacterial infection, including bacterial ... The most common viral causes are influenza, parainfluenza, human respiratory syncytial virus, human metapneumovirus and ...
"Oncolytic adenovirus modified with somatostatin motifs for selective infection of neuroendocrine tumor cells". Gene Therapy. 18 ... Human alpha-1-antitrypsin is another protein that has been produced from goats and is used in treating humans with this ... Sato K, Sasaki E (February 2018). "Genetic engineering in nonhuman primates for human disease modeling". Journal of Human ... Mammals are the best model organisms for humans, making ones genetically engineered to resemble serious human diseases ...
Infection by human adenovirus accounts for 65% to 90% of cases of viral conjunctivitis. Adenoviruses are the most common cause ... Bacterial infections, allergies, other irritants, and dryness are also common causes. Both bacterial and viral infections are ... "Molecular epidemiology of circulating human adenovirus types in acute conjunctivitis cases in Chandigarh, North India". Indian ... The viral infection may occur along with other symptoms of a common cold. Both viral and bacterial cases are easily spread ...
... and adenovirus 11. AHC can only exist in a human host and is transmitted through human contact with an infected individual or ... There are 57 variants of this virus, that each cause 5-10% of upper respiratory infections in humans. These viruses are some of ... Adenoviruses are a medium-sized variant that are nonenveloped, like Enterovirus 70. They have a double-stranded linear DNA ... Within one to two days of infection, symptoms will begin to become apparent. Enterovirus 70 is a member of the genus of viruses ...
"Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer ... Falk W, Leonard EJ (May 1982). "Chemotaxis of purified human monocytes in vitro: lack of accessory cell requirement". Infection ... "The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection". PLOS ONE. 7 (8): ... In humans, 19 family members are currently known, with most S100 genes (S100A1 to S100A16). Proteins in the S100 gene family ...
"Oncolytic adenovirus modified with somatostatin motifs for selective infection of neuroendocrine tumor cells". Gene Therapy. 18 ... The researchers forecast that one day this technique could be used to restore the heartbeat in humans who would otherwise need ... Genetically-modified virus explodes cancer cells GM virus shrinks cancer tumours in humans Leja J, Yu D, Nilsson B, Gedda L, ... However, it was not established that either of the two viruses were capable of infection or replication. In 1974, the first ...
They cause respiratory, intestinal, and eye infections in humans (especially the common cold). When these viruses infect a host ... It was found that in the absence of the E1B-55Kd viral protein, adenovirus caused very rapid apoptosis of infected, p53(+) ... Antibodies to HSV-1 are common in humans, however complications due to herpes infection are somewhat rare. Caution for rare ... There are two main types of virus infection: lytic and lysogenic. Shortly after inserting its DNA, viruses of the lytic cycle ...
Adenoviruses account for about 10% of acute respiratory infections in children.[citation needed] These viruses are a frequent ... The antifungal efficacy of copper was compared to aluminium on the following organisms that can cause human infections: ... Within six hours, 99.999% of the adenovirus particles were inactivated. Within six hours, 50% of the infectious adenovirus ... Adenovirus is a group of viruses that infect the tissue lining membranes of the respiratory and urinary tracts, eyes, and ...
Data show that HUVEC cells overexpressing T-cadherin after adenovirus infection enter S-phase more rapidly and exhibit ... T-cadherin at the US National Library of Medicine Medical Subject Headings (MeSH) CDH13 human gene location in the UCSC Genome ... Re-expression of T-cadherin in human breast cancer cells (MDAMB435) in culture, which originally do not express T-cadherin, ... 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics ...
... treatment with Ezh1/2 inhibitors reduced infection of multiple viral pathogens, including human cytomegalovirus, adenovirus, ... the site of infection, and whether the infection is primary (initial infection) or recurrent (recurring symptoms). Popular, ... Upon initial infection, herpes simplex virus (HSV) causes acute lytic infection of epithelial cells, usually at either genital ... HSV infection can cause corneal scarring and blindness from herpes keratitis, central nervous system infections, and even death ...
In 2017, the ChAdOx1 vector was used in a trial for a vaccine candidate against human malaria infection. The researchers ... However, the widespread seroprevalence of neutralizing antibodies to common human adenovirus serotypes limits their use. Simian ... The vector is a chimpanzee adenovirus modified to avoid its replication. Adenoviruses are effective vectors for inducing and ... "A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative ...
Recombinant Adenovirus-Based Vaccine Provides Long-Term Protection for Non-Human Primates from Lethal Ebola Infection". ... It contains a human adenovirus serotype 5 vector (Ad5) with the glycoprotein gene from ZEBOV. Their findings were consistent ... The Ad26.ZEBOV is derived from human adenovirus serotype 26 (Ad26) expressing the Ebola virus Mayinga variant glycoprotein, ... Vaccines include replication-deficient adenovirus vectors, replication-competent vesicular stomatitis (VSV) and human ...
"Human herpesvirus 7 infection of lymphoid and myeloid cell lines transduced with an adenovirus vector containing the CD4 gene ... Dewhurst, S (2004). "Human Herpesvirus Type 6 and Human Herpesvirus Type 7 Infections of the Central Nervous System". Herpes: ... "Reactivation of human herpesvirus 6 by infection of human herpesvirus 7". Journal of Medical Virology. 60 (3): 284-9. doi: ... Yoshikawa, T (2003). "Human Herpesvirus-6 and -7 Infections in Transplantation". Pediatric Transplantation. 7 (1): 11-17. doi: ...
Human Neutrophil Defensin-1, -3, and -4 Are Elevated in Nasal Aspirates from Children with Naturally Occurring Adenovirus ... 4 Are Elevated in Nasal Aspirates from Children with Naturally Occurring Adenovirus Infection," Canadian Respiratory Journal, ... Initially human alpha defensin peptides were isolated from the neutrophils and are thus called human neutrophil peptides. Human ... Human neutrophil peptides are found in human atherosclerotic arteries, inhibit LDL metabolism and fibrinolysis and promote Lp(a ...
Non-LPD that have significant percentages of cases associated with EBV infection (see Epstein-Barr virus infection) include the ... Human herpes virus 8 (HHV8) is associated with four rare lymphoproliferative disorders: 1) a subset of diffuse large B cell ... adenovirus, or toxoplasma. HIV, rubella, and Hepatitis viruses A, B, and C can produce an illness resembling IM. The acute EBV ... Worldwide, EBV infection is associated with 1% to 1.5% of all cancers. The vast majority of these EBV-associated cancers are ...
In addition, DPPC has been shown to be related to infection of polarized cells by a specific kind of human adenovirus (HAdV-C2 ... However, adsorption is not optimal at human body temperature for DPPC alone, because at 37 °C it is found in a gel phase. The ... This phospholipid is found in a solid/gel phase at 37 °C (at the effective temperature of the human body). Its melting point is ... It also plays an important role in the study of liposomes and human bilayers. Lung surfactant (LS) is a surface-active material ...
The vaccine contained three separate replication-defective vectors based on Human Adenovirus C serotype 5 (HAdV-5). Each of the ... In fact, certain groups of the vaccine recipients were seen to have a higher risk of HIV infection as compared to the placebo ... Study was a Phase IIb clinical trial intended to study the efficacy of an experimental HIV vaccine based on a human adenovirus ... It was hoped that the adenovirus vectors would carry these HIV-1 genes into the cell, and that this would result in the ...
They also emerged as a vehicle for human gene therapy Also in the early 1960s, Green and others showed that human adenoviruses ... and determining the molecular and kinetic parameters of adenovirus infection. He showed that adenoviruses could be divided into ... His major focus of investigation was human adenoviruses. He and his colleagues worked out the basic parameters for working with ... In 1962, scientists at the National Institutes of Health discovered that certain serotypes of human adenoviruses can induce ...
During his time at the Wellcome Trust Centre for Human Genetics his research group studied genetic susceptibility to infections ... He is now[when?] developing vaccines which produce cellular (T-cell) immunity using Adenovirus and Modified vaccinia Ankara ( ... Professor of Human Genetics at the University of Oxford, Consultant Physician and Fellow of Magdalen College, Oxford. Hill ...
Additionally, m6A has been reported to impact viral infections. Many RNA viruses including SV40, adenovirus, herpes virus, Rous ... Mapping of m6A in human and mouse RNA has identified over 18,000 m6A sites in the transcripts of more than 7,000 human genes ... "Dynamics of Human and Viral RNA Methylation during Zika Virus Infection". Cell Host & Microbe. 20 (5): 666-673. doi:10.1016/j. ... m6A is also found on the RNA components of R-loops in human cells, where it is involved in regulation of stability of RNA:DNA ...
The adenovirus cannot replicate, so does not cause further infection, and instead acts as a vector to transfer the SARS-CoV-2 ... In early April the team were awarded £22 million of funding from the Government of the United Kingdom to run human trials. The ... After earning her doctorate, Green moved to the Curie Institute, where she studied DNA damage in human cells as a Marie Curie ... In 2012 Green moved to the University of Oxford, where she joined the Wellcome Centre for Human Genetics. Here Green expanded ...
Humans infected with adenoviruses display a wide range of responses, from no symptoms at all to the severe infections typical ... In humans, currently there are 88 human adenoviruses (HAdVs) in seven species (Human adenovirus A to G): A: 12, 18, 31 B: 3, 7 ... Most infections with adenovirus result in infections of the upper respiratory tract. Adenovirus infections often present as ... and avoiding close contact with people with symptomatic adenovirus infection. Those with symptomatic adenovirus infection are ...
Carrigan, Phd (1997). "Adenovirus Infections in Immunocompromised Patients". The American Journal of Medicine. 102 (3): 71-74. ... 2008). "Acute meningoencephalitis due to human immunodeficiency virus type 1 infection in 13 patients: clinical description and ... If caused by an infection then the infection can be treated with antibiotic drugs. Meningitis Meningism Primary amoebic ... which is an infection or inflammation of the meninges, and encephalitis, which is an infection or inflammation of the brain. ...
Viral Infections and Treatment,display-editors=etal,editor-first=Helga,editor-last=Rübsamen-Waigmann,first2=Frederick G.,last2= ... adenoviruses]] (5%),,ref name=Medscape /, [[ Virusi sinkytial i frymëmarrjes njerëzore,virusi]] sinkytial i [[ Virusi sinkytial ... Sequencing and Analyses of All Known Human Rhinovirus Genomes Reveals Structure and Evolution,url=,journal=Science,language=en, ... The economic burden of non-influenza-related viral respiratory tract infection in the United States,url=,journal=Arch. Intern. ...
"Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA- ... For example, one study used the adenovirus TATA promoter sequence (5'-CGCTATAAAAGGGC-3') as a model binding sequence and found ... "Expression and nuclear localization of the TATA-box-binding protein during baculovirus infection". The Journal of General ... One study found less than 30% of 1031 potential promoter regions contain a putative TATA box motif in humans.[9] In Drosophila, ...
"Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection". J. Virol. 72 (12): 9918-23. ... Adenovirus Adenovirus infection. RNA virus. Rotavirus. Norovirus. Astrovirus. Coronavirus. Hepatitis. DNA virus. HBV (B). RNA ... Infection and pathogenesis[edit]. The initial site of infection may be the tonsils,[4] or possibly the gastrointestinal tract.[ ... The JC virus or John Cunningham virus is a type of human polyomavirus (formerly known as papovavirus). It was identified by ...
Tetanus toxin is so lethal that humans cannot develop immunity to a natural infection, as the amount of toxin and time required ... Immunity against infections that can cause serious illness is generally beneficial. Since Pasteur provided support for a germ ... Synthetic (recombinant or cell-clone) human immunoglobulins can now be made, and for several reasons (including the risk of ... The earliest recorded artificial induction of immunity in humans was by variolation or inoculation, which is the controlled ...
"Opisthorchis felineus and Metorchis bilis are the main agents of liver fluke infection of humans in Russia". Parasitol. Int. 61 ... Adenoviridae: Adenovirus. *Arenavirus: Guanarito virus,[2] Junín virus,[2] Lassa fever virus,[2] Lujo virus,[3] Machupo virus[2 ... Herpesvirus: Cytomegalovirus,[17] Epstein Barr virus,[18] Varicella zoster virus, Human herpesvirus 6, Human herpesvirus 7 ve ... "Zoonotic helminth infections of humans: echinococcosis, cysticercosis and fascioliasis". Curr. Opin. Infect. Dis. 20 (5), s. ...
This is most commonly seen in Pseudomonas infection, but it can be caused by other types of bacteria or fungi. These infectious ... It is caused most commonly by Herpes simplex, Herpes zoster and Adenoviruses. Also it can be caused by coronaviruses & many ... Corneal ulcers are a common human eye disease. They are caused by trauma, particularly with vegetable matter, as well as ... Protozoa infection like Acanthamoeba keratitis is characterized by severe pain and is associated with contact lens users ...
Ear infections occur in 30% of cases.[56] Likelihood[change , change source]. The common cold is the most common human disease[ ... adenoviruses, Enteroviruses, and metapneumovirus.[12] Frequently, more than one virus is present and causing the infection.[13] ... Acute infections of the nose, sinuses, throat or larynx (upper respiratory tract infections, URI or URTI) are sorted by the ... The flu causes 5% to 15% of cases.[3] Other cases may be caused by human parainfluenza viruses, human respiratory syncytial ...
A respiratory syncytial virus vaccine (RSV vaccine) is a vaccine which prevents infection by respiratory syncytial virus. No ... The desired vaccine would prevent lower respiratory infection from RSV in at-risk populations and if possible be useful in ... Cedillo v. Secretary of Health and Human Services. *Alternative vaccination schedule. Related. *Epidemiology ...
Animals are vaccinated to keep them from getting diseases, and to keep them from infecting humans with diseases.[19] Pets as ... Scientists are trying to make vaccines to help cure chronic infections, instead of only preventing disease.[20] ... adenovirus-2, leptospirosis, bordatella, canine parainfluenza virus, and Lyme disease. ... Olesen OF, Lonnroth A, Mulligan B (2009). "Human vaccine research in the European Union". Vaccine 27 (5): 640-5. doi:10.1016/j. ...
B23.) Human Immunodeficiency Virus (HIV) disease Resulting in other conditions *(B23.0) Acute HIV infection syndrome ... B97.0) Adenovirus as the cause of diseases classified to other chapters ... A31.) Infection due to other mycobacteria *(A31.0) Pulmonary mycobacterial infection *Infection due to Mycobacterium avium ... A80-B34 - Viral infections[संपादित करें]. (A80-A89) Viral infections of the central nervous system[संपादित करें]. *(A80.) Acute ...
Humans[edit]. Aluminium salts used in many human vaccines are generally regarded as safe.[25] ... they may induce the release of inflammatory cytokines which helps to not only recruit B and T cells at sites of infection but ... Squalene is also produced by the human liver and present in human sebum.[11] MF59 is an oil-in-water emulsion of squalene ... "T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: comparison of gene ...
The vaccine contains a G1P[8] human rotavirus strain.[23] Lanzhou lamb[edit]. Lanzhou lamb rotavirus vaccine was licensed for ... Rotavirus vaccine is a vaccine used to protect against rotavirus infections, which are the leading cause of severe diarrhea ... It contain human bovine reassortant strains of rotavirus serotypes G1, G2, G3, G4 and G9. This is world's first thermostable ... It is a live attenuated, monovalent vaccine containing a G9P[11] human strain isolated from an Indian child.[21] It is given by ...
Then they inject the adenovirus into a human body. The human immune system learns to recognize the pieces of dangerous viruses ... "Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2" (PDF). Cell. doi: ... The adenovirus is the virus that causes the common cold.[1] It does not harm the human body much. Scientists have used the ... They tested APN01 in engineered human tissue. This is human cells put together to act like part of the body, but it is not a ...
Human Papillomavirus නම් වෛරස් එන්නත නිෂ්පාදනය කර ඇත්තේ වෛරසයෙහි කැප්සිඩ ප්‍රෝටීන මගිනි. ... Artificial induction of immunity / Immunization: Vaccines, Vaccination, Infection, Inoculation (J07). Development. *Adjuvants ...
... is a vaccine that protects in humans against hantavirus infections causing Hantavirus hemorrhagic fever with ... Field trial of an inactivated vaccine against hemorrhagic fever with renal syndrome in humans. Arch Virol. 1990;1(Suppl):35-47. ... Antibody responses in humans to an inactivated hantavirus vaccine (Hantavax). Vaccine. 1999;17:2569-75. ... A phase 2 study on a human HTNV/PUUV DNA hantavirus vaccine is ongoing.[4] ...
Adenovirus Adenovirus infection. RNA virus. Rotavirus. Norovirus. Astrovirus. Coronavirus. Hepatitis. DNA virus. HBV (B). RNA ... Lukes RJ, Collins RD (October 1974). "Immunologic characterization of human malignant lymphomas". Cancer. 34 (4 Suppl): 1488- ... Untreated, median survival is only 2.5 months, sometimes due to concurrent opportunistic infections rather than the lymphoma ... infection (, 90%) in immunodeficient patients (such as those with AIDS and those immunosuppressed),[2] and does not have a ...
"Epidemic keratoconjunctivitis" is caused by an adenovirus infection.. *"Infectious bovine keratoconjunctivitis" (IBK) is a ...
Adenovirus Adenovirus infection. RNA virus. Rotavirus. Norovirus. Astrovirus. Coronavirus. Hepatitis. DNA virus. HBV (B). RNA ...
"Human Vaccines. 7. 7: 734-748. doi:10.4161/hv.7.7.15511. PMID 21734466. Nakuha noong 10 May 2012.. Unknown parameter ,month=. ... Mandell, Gerald L.; Bennett, John E.; Dolin, Raphael (2004). Mandell's Principles and Practices of Infection Diseases (6th ... Gastroenteritis viruses: A = rotavirus, B = adenovirus, C = Norovirus and D = Astrovirus. The virus particles are shown at the ... "Human Vaccines. 6 (7): 532-542. PMID 20622508. Nakuha noong 10 May 2012.. Unknown parameter ,month=. ignored (tulong)CS1 maint ...
Ebola-virus infection I Recruiting Tekmira Pharmaceutical NCT01518881 ALN-RSV01 RSV nucleocapsid Naked siRNA Respiratory ... "Human Molecular Genetics. 20 (R1): R21-7. doi:10.1093/hmg/ddr137. PMC 3095054. PMID 21459775.. ... adenovirus[150] and measles virus.[151] The other strategy is to block the initial viral entries by targeting the host cell ... 45,000 miRNA target sites within human mRNA 3'UTRs are conserved above background levels, and ,60% of human protein-coding ...
... cyclic neutropenia and human immunodeficiency virus infection. In cyclic neutropenia, more severe oral ulceration occurs during ... adenovirus, and cytomegalovirus.[5] Some people with aphthous stomatitis may show herpes virus within the epithelium of the ... Fasten healing (prevent secondary infection). Doxycycline,[6] tetracycline,[6] minocycline,[21] chlorhexidine gluconate,[14] ... Opportunistic infections commonly occur and aphthous-like ulceration is worst during this time.[14] ...
... as well as viruses such as adenovirus, astrovirus and calicivirus. Other less common pathogens include Bacillus cereus, ... "Human Campylobacteriosis in Developing Countries1". Emerging Infectious Diseases. 8 (3): 237-243. doi:10.3201/eid0803.010233 ... "Pathogenesis of intestinal and systemic rotavirus infection". Journal of Virology. 78 (19): 10213-10220. doi:10.1128/JVI.78.19 ...
Human vaccines[edit]. Viral diseases[edit]. Virus. Diseases or conditions. Vaccine(s). Brands ... oral adenovirus type 4 and type 7 vaccine, in U.S. Military recruits". Vaccine. 31 (28): 2963-2971. doi:10.1016/j.vaccine. ... Frontiers in Cellular and Infection Microbiology. 2. doi:10.3389/fcimb.2012.00016.. ... "Human Vaccines. 7 (11): 1192-1197. doi:10.4161/hv.7.11.17017. PMC 3323497 . PMID 22048120.. ...
The progression of the human immunodeficiency virus infection into AIDS is due primarily to the depletion of CD4+ T-helper ... The adenovirus E1B-55K protein and the hepatitis B virus HBx protein are examples of viral proteins that can perform such a ... The average adult human loses between 50 and 70 billion cells each day due to apoptosis.[a] For an average human child between ... Liu Y, McKalip A, Herman B (May 2000). "Human papillomavirus type 16 E6 and HPV-16 E6/E7 sensitize human keratinocytes to ...
Testing of HeLa cells and human cells to exposure of both feline parvovirus and canine parvovirus resulted in infections of the ... which only work with a helper virus such as adenovirus. Other viruses that can infect without helper viruses are called as ... Humans can be infected by viruses from five of the eight genera in the subfamily Parvovirinae: i) Bocaparvovirus (e.g. human ... Some infections do not result in visible infection, while some manifest with visible effects, such as fifth disease (erythema ...
Adenovirus Adenovirus infection. RNA virus. Rotavirus. Norovirus. Astrovirus. Coronavirus. Hepatitis. DNA virus. HBV (B). RNA ... Human polyomavirus 2 Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV ... Infection with one genotype does not confer immunity against others, and concurrent infection with two strains is possible. In ... Small and promising human trials have shown beneficial results and no serious side effects, but they were too small to ...
Re-‬‬Emerging Human Viral Hemorrhagic Fevers: ‭ ‭A Review. ‬‬‬American Journal of Infectious Diseases and Microbiology‭ 201‭6‬‬ ... May 17, 2007, Science Daily: Herpes infection might have an up side Citat: "...U.S. medical scientists say a herpes virus ... Model af adenovirus-kapsid, prototypen på et kapsid af en dsDNA-virus ... Livmoderhalskræft forårsages af HPV, human papillomavirus, en lille DNA oncovirus med en proteinkappe og et genom af cirkulært ...
HumansEdit. Generally, the maned wolf is shy and flees when alarmed, so it poses little direct threat to humans. Popularly, the ... canine adenovirus, protozoan Toxoplasma gondii, bacterium Leptospira interrogans, and nematode Dirofilaria immitis.[35][34] The ... maned wolf is particularly susceptible to potentially fatal infection by the giant kidney worm. Ingestion of the wolf apple ... In human culturesEdit. Human attitudes and opinions about the maned wolf vary across populations, ranging from fear and ...
"Prevention of Hepatitis B Virus Infection in the United States: Recommendations of the Advisory Committee on Immunization ... Cedillo v. Secretary of Health and Human Services. *Alternative vaccination schedule. Related. *Epidemiology ...
Pseudo-Outbreak of Adenovirus Infection in a Neonatal Intensive Care Unit Due to a False-Positive Antigen Detection Test Howard ... Computational Analysis Identifies Human Adenovirus Type 55 as a Re-Emergent Acute Respiratory Disease Pathogen Michael P. Walsh ... Quantitative Detection and Rapid Identification of Human Adenoviruses Rika Miura-Ochiai, Yasushi Shimada, Tsunetada Konno, ... Outbreak of Febrile Respiratory Illness Associated with Adenovirus 11a Infection in a Singapore Military Training Camp Adriana ...
However, we report here that preexisting virus-specific T cell responses also contribute to promoting adenovirus (Ad) infection ... In this study, we found that the efficacy of Ad infection into CD14+ monocytes was significantly decreased after CD3+ T ... And taken together, these results suggest a novel role of virus-specific T cells in mediating enhancement of viral infection, ... Further studies demonstrated that GM-CSF and IL-4 can promote Ad infection by up-regulating the expression of scavenger ...
Cui X, Wen L, Wu Z, Liu N, Yang C, Liu W, Human adenovirus type 7 infection associated with severe and fatal acute lower ... Severe Infections with Human Adenovirus 7d in 2 Adults in Family, Illinois, USA, 2014 On This Page ... Severe Infections with Human Adenovirus 7d in 2 Adults in Family, Illinois, USA, 2014. Emerging Infectious Diseases. 2016;22(4 ... Severe Infections with Human Adenovirus 7d in 2 Adults in Family, Illinois, USA, 2014. Emerg Infect Dis. 2016;22(4):730-733. ...
... can cause respiratory infections, some severe. HAdV-B7, which can cause severe respiratory disease, has not been recently ... and clinicians should consider HAdV in persons with severe respiratory infection. ... Human Adenovirus Associated with Severe Respiratory Infection, Oregon, USA, 2013-2014 Magdalena Kendall Scott. , Christina ... Human Adenovirus Associated with Severe Respiratory Infection, Oregon, USA, 2013-2014. ...
... transformed B lymphocytes from human umbilical cord blood and from woolly monkey blood. Adenovirus could be recovered from ... Chronic infection with adenovirus types 5 and 6 was established in primary mononuclear leukocytes from human umbilical cord ... Persistent infection with adenovirus types 5 and 6 in lymphoid cells from humans and woolly monkeys J Infect Dis. 1982 Jan;145( ... Chronic infection with adenovirus types 5 and 6 was established in primary mononuclear leukocytes from human umbilical cord ...
Differential Susceptibility of Primary and Established Human Glioma Cells to Adenovirus Infection: Targeting via the Epidermal ... Differential Susceptibility of Primary and Established Human Glioma Cells to Adenovirus Infection: Targeting via the Epidermal ... Differential Susceptibility of Primary and Established Human Glioma Cells to Adenovirus Infection: Targeting via the Epidermal ... Differential Susceptibility of Primary and Established Human Glioma Cells to Adenovirus Infection: Targeting via the Epidermal ...
Transformation of Human Bronchial Epithelial Cells by Infection with SV40 or Adenovirus-12 SV40 Hybrid Virus, or Transfection ... Transformation of Human Bronchial Epithelial Cells by Infection with SV40 or Adenovirus-12 SV40 Hybrid Virus, or Transfection ... Transformation of Human Bronchial Epithelial Cells by Infection with SV40 or Adenovirus-12 SV40 Hybrid Virus, or Transfection ... Transformation of Human Bronchial Epithelial Cells by Infection with SV40 or Adenovirus-12 SV40 Hybrid Virus, or Transfection ...
Cellular Response to Infection. Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the ... SPOC1-mediated antiviral host cell response is antagonized early in human adenovirus type 5 infection. PLoS Pathog 9:e1003775. ... Human adenoviruses (HAdVs) are common pathogens, and their infections cause a wide range of diseases, including respiratory ... Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII ...
Replication-Deficient Human Adenovirus Type 35 Vectors for Gene Transfer and Vaccination: Efficient Human Cell Infection and ... Replication-Deficient Human Adenovirus Type 35 Vectors for Gene Transfer and Vaccination: Efficient Human Cell Infection and ... Replication-Deficient Human Adenovirus Type 35 Vectors for Gene Transfer and Vaccination: Efficient Human Cell Infection and ... Replication-Deficient Human Adenovirus Type 35 Vectors for Gene Transfer and Vaccination: Efficient Human Cell Infection and ...
The source of such infections is often difficult to assess, that is, whether acquired as a primary infection, exposure to a ... We present here 2 cases of likely transplant-acquired HAdV-34 infection from the same organ donor, manifesting as ... infection is a recognized cause of transplant-associated hemorrhagic cystitis and, in rare cases, tubulointerstitial nephritis ... pathogen in the transplanted organ, or reactivation of an endogenous latent infection. ...
Human adenovirus (HAdV) is one of the most common pathogens associated with viral ARI, and thus calls for specific diagnosis ... In addition, epidemiological features and co-infection with other human respiratory pathogens were investigated and analyzed. ... The most common co-infection pathogens with HAdV were MP (57.1%) and Human Bocavirus (HBoV) (16.7%). The majority of HAdV ... Seasonal peaks of HAdV infection occurred in the summer season of 2012 and 2013; the predominant HAdV type was HAdV-3 (70%), ...
In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited ... Background Human Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. They particularly cause frequent ... In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited ... In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited ...
"Adenoviruses to date have not generally been linked to cross-species infections between monkeys and humans," Chiu said. ... a more virulent strain of human adenovirus arose from recombination with other distinct strains of milder human adenoviruses. ... Adenoviruses commonly infect humans, causing colds, flu-like symptoms and sometimes even death, but now UC San Francisco ... Last year, Chiu and colleagues also identified another new adenovirus, named simian adenovirus C, which sickened four of nine ...
Adenovirus infection and insulin release.. Fetal islet-like cell clusters were cultured on HTB-9 matrices for 2 days before ... Human adult islets (age 45-56 years) of 30-40% purity were obtained through the Human Islet Distribution Program (City of Hope ... Adenovirus infection did not significantly affect β-cell viability or adhesion to vitronectin. ... infection with an adenovirus expressing green fluorescent protein (GFP) and a dominant-negative form of ERK-2 (Ad-DN-ERK) (21 ...
Morris, S. J., Scott, G. E., Leppard, K. N. Adenovirus late-phase infection is controlled by a novel L4 promoter. J. Virol. 84 ... Wright, J., Leppard, K. N. The human adenovirus 5 L4 promoter is activated by cellular stress response protein p53. J. Virol. ... The Mre11 Cellular Protein Is Modified by Conjugation of Both SUMO-1 and SUMO-2/3 during Adenovirus Infection. ISRN Virology. ... Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells. J. Vis. ...
... ... Thus we speClllated that abortive infection of HeLa cells by adenoviruses may be averted by providing EtA functions in trans. ... Infection of hUlnan cells by bovine adenovirlls type 2 (BAV2) is abortive. To obtain a better understanding of this ... This further suggests that the abortive infection b:y BAV2 could be attributed to failure of EIA to express dlle to a ...
Adenovirus Infection of Neonatal Rat Cardiomyocytes. For testing specificity of antibodies, neonatal rat cardiac myocytes were ... The mRNA and protein levels of ICa,L, RyR2, calsequestrin (CSQ), Serca2a, PLB, and Tn-I were stable in human cAF.5,13-19 ... Molecular Determinants of Altered Ca2+ Handling in Human Chronic Atrial Fibrillation. Ali El-Armouche, Peter Boknik, Thomas ... We have recently shown that reduced ICa,L amplitude in human cAF is associated with increased activity of type 1 (PP1) and type ...
Infection of human macrophages with adenovirus. The freshly isolated human peripheral monocytes were differentiated with 10% ... Suppression of LPS-induced TNF-α secretion by human macrophages transduced with adenovirus vectors expressing DN versions of NF ... Controversy exists as to the ability of the human κB3 site to activate the human TNF-α promoter (7, 8, 40). Our data clearly ... THP-1 human monocytic cells were obtained from ATCC and maintained in RPMI 1640 medium with 10% FCS. Human blood mononuclear ...
Influenza, Human. Orthomyxoviridae Infections. RNA Virus Infections. Virus Diseases. Respiratory Tract Infections. Respiratory ... Safety and Immunogenicity of Replication-Competent Adenovirus 4-vectored Vaccine for Avian Influenza H5N1. The safety and ... Other Name: Adenovirus Serotype 4-vectored H5N1 Influenza Vaccine. Biological: Sanofi Pasteur Influenza Virus Vaccine, H5N1 ... Other Name: Adenovirus Serotype 4-vectored H5N1 Influenza Vaccine. Biological: Sanofi Pasteur Influenza Virus Vaccine, H5N1 ...
Adenoviruses are human pathogens that commonly infect the respiratory and gastrointestinal tracts (1). Adenovirus infections ... Adenoviruses. In: Evans AS, Kaslow RS, eds. Viral infections of humans. 4th ed. New York, New York: Plenum Medical Book Co., ... McDonough M, Kew O, Hierholzer J. PCR detection of human adenoviruses. In: Persing DH, Smith TF, Tenover FC, White TJ, eds. ... Six specimens yielded adenovirus, identified as subgenus B by the polymerase chain reaction assay, and as adenovirus 11 by ...
P , 0.01, Ad-36 infection + Ras RNAi vs. Ad-36 infection alone. B: Time course of Ad-36 infection in HSKM with or without Ras ... Adenovirus type 2, a human adenovirus that is not adipogenic in animals (9), was used as a negative control. The following ... Human Adenovirus Type 36 Enhances Glucose Uptake in Diabetic and Nondiabetic Human Skeletal Muscle Cells Independent of Insulin ... Human Adenovirus Type 36 Enhances Glucose Uptake in Diabetic and Nondiabetic Human Skeletal Muscle Cells Independent of Insulin ...
Any active clinically serious infections (, grade 2 NCI-CTCAE ver 3.0). *HIV infection or AIDS-related illness or serious acute ... Drug: Recombinant Human Adenovirus Type 5 Injection After identifying the target artery of HCC, Recombinant Human Adenovirus ... Recombinant Human Adenovirus Type 5, an E1B gene deleted adenovirus, is known to have a significant antitumor activity. In ... Experimental: TACE Plus Adenovirus After identifying the target artery of HCC, Recombinant Human Adenovirus Type 5 Injection( ...
Lion T. Adenovirus infections in immunocompetent and immunocompromised patients. Clin Microbiol Rev 2014;27:441-62. CrossRef ... Notes from the Field: Fatalities Associated with Human Adenovirus Type 7 at a Substance Abuse Rehabilitation Facility - New ... Notes from the Field: Fatalities Associated with Human Adenovirus Type 7 at a Substance Abuse Rehabilitation Facility - New ... During December 2016-January 2017, NJDOH surveillance for noninfluenza respiratory viruses identified multiple human adenovirus ...
In September 2018, a high positive rate of human adenovirus HAdV was occurred among hospitalized children in the Childrens ... Nosocomial infections are common in pediatric patients and can be fatal in infants and immunocompromised patients. ... Keywords: Acute respiratory tract infection; Human adenovirus (HAdV); Nosocomial infection; Phylogenetic analysis. ... Application of Human Adenovirus Genotyping by Phylogenetic Analysis in an Outbreak to Identify Nosocomial Infection Chuanyu ...
... * * Juan Yu 1,3 , ... Zou L, Zhou J, Li H, Wu J, Mo Y, Chen Q, Fang L, Wu D, Ke C (2012) Human adenovirus infection in children with acute ... Human adenovirus (HAdV) genotypes HAdV-B, HAdV-C, and HAdV-E are usually associated with respiratory infection; HAdV-A, -D, -F ... Molecular Characterization of Human Respiratory Adenoviruses Infection in Xining City, China In 2018 [J].VIROLOGICA SINICA. ...
E4-ORF3 clears the way for adenovirus to proliferate by deactivating genes that help the cell defend itself against the virus. ... First Adenovirus Cross Species Monkey-Human Jump Confirmed by UCSF. A novel virus that spread through a California monkey ... Eye Infection from Adenoviruses can Be Treated by Gamma Globulin. A study conducted by researchers at the University Of ... Adenoviruses Could Help Kick Drinking. A single injection of a type of virus known as adenoviruses can help give up the habit ...
Lower respiratory tract infections in children are often viral in origin. Unfortunately in this time of significant ... Other important respiratory viruses include human metapneumovirus, parainfluenza virus types 1 and 3, adenovirus, influenza A ... be important viral-bacterial co-infections [27]. Bacterial infections may complicate cases of respiratory viral infections but ... Infection with RSV does not result in permanent or long-term immunity, as re-infections, usually of lesser severity, are common ...
... or treatment-refractory viral infections. Herpesvirus, adenovirus, human papillomavirus ... [ Time Frame: 5 years ]. ... Infections caused by viruses are common causes of illnesses: the common cold, many ear infections, sore throats, chicken pox, ... including infection caused by herpesviruses (HSV-1, HSV-2, CMV, EBV, VZV, HHV-6, HHV-7, HHV-8), human papillomavirus (e.g., ... severe recalcitrant warts), adenovirus, polyomavirus (such as JC virus and BK virus), or influenza virus. Viral infections that ...
The most well-known of these infections is the common cold. Find out about other types of URIs, their causes, and how theyre ... is a contagious infection of the upper respiratory tract. This area of the body includes the nose, throat, pharynx, larynx, and ... adenovirus. *coxsackievirus. *parainfluenza virus. *respiratory syncytial virus. *human metapneumovirus. Bacteria. *group A ... Acute respiratory infection is an infection that may interfere with normal breathing. It usually begins as a viral infection in ...
We recently found that human alpha-defensins inhibit human adenovirus (HAdV) by preventing virus uncoating and rel … ... provide insight into the mechanism of AdV uncoating and suggest new strategies to disrupt this process and inhibit infection. ... We recently found that human alpha-defensins inhibit human adenovirus (HAdV) by preventing virus uncoating and release of the ... Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization PLoS Pathog. 2010 Jun 24;6 ...
  • In March 1997, an outbreak of acute respiratory disease (ARD) caused by adenovirus serotype 11 occurred among students at a job training facility in South Dakota. (
  • Ad14 (for adenovirus serotype 14 ), has caused at least 140 illnesses in New York, Oregon, Texas and Washington, according to a report from the Centers for Disease Control and Prevention. (
  • [4] To date, the most thorough investigations have been conducted for adenovirus serotype 36 (Adv36). (
  • But it's a very safe bet that anyone reading this post, unless they are an extremely precocious toddler, has fought off more than one adenovirus serotype during their lifetime. (
  • After most adenovirus infections, antibodies are produced which are specific to, and reduce the likelihood of future infection with, that serotype. (
  • Centers for Disease Control and Prevention (CDC) (2007) Acute respiratory disease associated with adenovirus serotype 14 - four states, 2006-2007. (
  • one tablet protects against adenovirus serotype 4 (white tablet) and one tablet protects against adenovirus serotype 7 (peach-colored tablet). (
  • Preincubation of virions with heparin or pretreatment of cells with heparinase I indicated that the role of cell surface heparan sulfate during FIX- and FX-mediated adenovirus binding and infection is mechanistically serotype specific. (
  • Continuous outbreaks of adenovirus (Ad)â€"associated acute respiratory disease were documented among US trainees before the implementation of serotype 4 (Ad4) and serotype 7 vaccines in 1971. (
  • Molecular characterization beyond serotype is critical to understanding the transmission dynamics of Ad infection in these unique susceptible populations and to the implementation of effective prevention approaches. (
  • Antigenic variability among two subtypes of human adenovirus serotype 7. (
  • Limited testing of eye swabs suggested the causative agent was human adenovirus serotype 8. (
  • On day 14 after viral infection, mice received 10 4 CFU of S. pneumoniae (serotype 3) intranasally. (
  • And taken together, these results suggest a novel role of virus-specific T cells in mediating enhancement of viral infection, and provide insights to understand the pathogenesis and complicated interactions between viruses and host immune cells. (
  • Strategies to bypass NA to Ad5 viruses include switching of adenovirus type ( 28 , 32 , 36 ) and use of animal adenoviruses ( 13 , 25 , 34 ). (
  • Disadvantages of this strategy include the lack of knowledge regarding the biology of these viruses including tropism on human cells, potential difficulties in manufacturing, and the possibility of in vivo recombination with human types leading to unknown disease. (
  • Of the 47 types tested, subgroup B viruses Ad35 and Ad11 proved rarely neutralized by human sera. (
  • Adenoviruses are non-enveloped, double stranded DNA viruses that vary in size from 70 to 100 nm [ 1 ]. (
  • This study raises more concerns about the potential of unknown viruses to spread from animals to humans," said Chiu, who is an assistant professor of medicine at UCSF. (
  • We still don't understand the full extent of viruses that exist in the world and their potential to cause outbreaks in human populations. (
  • In light of these findings, however, he said the normal vigilance in tracking animal viruses that might also infect humans should extend beyond influenza and coronaviruses to include adenoviruses. (
  • In contrast, viruses that use DNA as their genetic material, such as adenoviruses, are thought to have less chance of spreading between species because they replicate with fewer mutations that could serve as the basis for infection-enhancing changes. (
  • During December 2016-January 2017, NJDOH surveillance for noninfluenza respiratory viruses identified multiple human adenovirus (HAdV) cases in the surrounding community. (
  • Esposito S, Daleno C, Prunotto G, Scala A, Tagliabue C, Borzani I, Fossali E, Pelucchi C, Principi N (2013) Impact of viral infections in children with community-acquired pneumonia: results of a study of 17 respiratory viruses. (
  • Infections caused by viruses are common causes of illnesses: the common cold, many ear infections, sore throats, chicken pox, and the flu are caused by different viruses. (
  • However, in some instances, apparently immunocompetent persons manifest infections with viruses that would otherwise be observed only in severely immunocompromised hosts. (
  • Most adenovirus LRTIs are mild and indistinguishable from LRTIs caused by other respiratory viruses. (
  • Nuclear-replicating viruses such as adenovirus have evolved mechanisms of chromatin manipulation to promote infection and subvert host defenses. (
  • However, several types of oncolytic viruses are human-specific and the lack of suitable immune-competent animal models complicates biologically relevant evaluation of their vaccine potential. (
  • Here, we aim to develop a murine cell line capable of supporting replication of a group B oncolytic adenovirus, enadenotucirev (EnAd), for incorporation into a syngeneic immunocompetent animal model to explore the oncolytic vaccine potential of group B oncolytic viruses. (
  • Adenoviruses (members of the family Adenoviridae ) are medium-sized (90-100 nm ), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome. (
  • Adenoviruses represent the largest known nonenveloped viruses. (
  • Because there are more than 200 viruses that cause the common cold, the human body can never build up resistance to all of them. (
  • Adenoviruses (AdVs) are non‐enveloped DNA viruses that can cause a wide range of clinical manifestations including respiratory, gastrointestinal and ocular, as well as hepatic, renal and disseminated diseases. (
  • Representing a major addition to the world literature on the subject, Viral Infections and Global Change explores trends of paramount concern globally, regarding the emergence and reemergence of vector-borne and zoonotic viruses. (
  • The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. (
  • When the researchers added adenoviruses to the tissue cultures, they found that the viruses activated the CD4 cells and caused them to grow and replicate. (
  • 1 - 5 Evidence to date suggests that viruses and bacteria interact, leading to upper and lower respiratory tract infections (URIs and LRIs, respectively). (
  • This group of viruses was discovered in the 1950s and includes 6 genera and 47 species (formerly referred to as serotypes) that cause sore throat and fever in humans, hepatitis in dogs, and several diseases in fowl, mice, cattle, pigs, and monkeys. (
  • Like the cold viruses, adenoviruses are often found in latent infections in clinically healthy persons. (
  • Some adenovirus serotypes can establish persistent asymptomatic infections in tonsils, adenoids, and intestines of infected people who can shed these viruses for months or years. (
  • Adenoviruses are medium-sized, nonenveloped icosohedral viruses containing double-stranded DNA. (
  • We conclude that the use of coagulation factors by adenoviruses may be of importance not only for the liver tropism seen when administering adenovirus vectors to the circulation but also during primary infections by wild-type viruses of their natural target cell types. (
  • Adenoviruses are common viruses that can cause illness in humans. (
  • Adenoviruses are very common viruses that infect humans. (
  • Adenoviruses are common viruses that cause a range of illness. (
  • We identified seasonal human coronaviruses, influenza viruses and rhinoviruses in exhaled breath and coughs of children and adults with acute respiratory illness. (
  • Our results indicate that surgical face masks could prevent transmission of human coronaviruses and influenza viruses from symptomatic individuals. (
  • Adenoviruses are viruses that cause respiratory infections in humans. (
  • Many DNA viruses elicit host DDRs during infection and some viruses require the DDR for efficient replication. (
  • Given that E2F activity is often deregulated by infection with DNA viruses, these observations raise the possibility that an E2F1-mediated mechanism of DDR activation may be conserved among DNA viruses. (
  • The most frequent combination of viruses identified was adenovirus and human rhinovirus. (
  • Fifty-one serotypes have been identified, and adenovirus type 3 (Ad3) and Ad7 have often been associated with outbreaks of severe respiratory tract infections. (
  • Among the 51 serotypes of human adenoviruses identified to date ( 4 ), about one-third are associated with human diseases. (
  • The serotypes frequently recovered from children with LRTIs are adenovirus type 1 (Ad1), Ad2, Ad3, Ad5, and Ad7. (
  • Forty-seven human adenoviruses serotypes have so far been identified adenovirus. (
  • Some adenoviruses (e.g., serotypes 1, 2, 5, and 6) have been shown to be endemic in parts of the world where they have been studied, and infection is usually acquired during childhood. (
  • for example, epidemic keratoconjunctivitis is associated with adenovirus serotypes 8, 19, and 37. (
  • Safe and effective adenovirus vaccines were developed for adenovirus serotypes 4 and 7, but were available only for preventing ARD among US military recruits, [7] and production stopped in 1996. (
  • in humans, more than 50 distinct adenoviral serotypes have been found to cause a wide range of illnesses , from mild respiratory infections in young children (known as the common cold ) to life-threatening multi-organ disease in people with a weakened immune system . (
  • CD46 for the group B human adenovirus serotypes and the coxsackievirus adenovirus receptor (CAR) for all other serotypes. (
  • There are actually 7 species of adenovirus that infect humans, designated as A through G, which consist of more than 60 serotypes between them. (
  • Adenoviruses can cause a variety of clinical manifestations because of high number of serotypes and their wide cell tropism. (
  • An oral attenuated live adenovirus vaccine against serotypes 4 and 7 is available for US militaries to prevent respiratory disease. (
  • There are at least 52 immunologically distinct serotypes of adenoviruses that can cause human infections. (
  • In the United States, adenovirus serotypes 4 and 7 most commonly cause respiratory illness. (
  • Human adenovirus type 7 (HAdV-7) is one of the major serotypes responsible for acute respiratory infection. (
  • PCR analysis of egyptian respiratory adenovirus isolates, including identification of species, serotypes, and coinfections. (
  • They were linked to human adenovirus serotypes 3 and 8, respectively. (
  • HAdV, human adenovirus. (
  • Surprisingly, the endogenous MKRN1 protein underwent proteasomal degradation during the late phase of HAdV-C5 infection in various human cell lines. (
  • Taken together, our results expand the functional repertoire of the HAdV-C5 precursor pVII protein in lytic virus infection and highlight MKRN1 as a potential common target during different virus infections. (
  • This mutual interaction between the pVII and MKRN1 proteins may prime MKRN1 for proteasomal degradation, because the MKRN1 protein is efficiently degraded during the late phase of HAdV-C5 infection. (
  • Inside the core, HAdV DNA associates with the viral proteins V, VII, Mu, terminal protein, and DNA-dependent adenovirus proteinase (Avp) ( 3 ). (
  • Human adenovirus type 34 (HAdV-34) infection is a recognized cause of transplant-associated hemorrhagic cystitis and, in rare cases, tubulointerstitial nephritis. (
  • We present here 2 cases of likely transplant-acquired HAdV-34 infection from the same organ donor, manifesting as tubulointerstitial nephritis in 1. (
  • Human adenovirus (HAdV) is one of the most common pathogens associated with viral ARI, and thus calls for specific diagnosis and better understanding of the epidemiology and clinical characteristics. (
  • This study will certainly facilitate HAdV vaccine development and treatment of HAdV infections in children. (
  • Methods To understand the epidemiology and type distribution of HAdV infections associated with RTIs in China, nasal swab (NS) clinical samples were collected from 4129 patients in a Guangzhou hospital between August 2017 and October 2019. (
  • HAdV infections were detected throughout the year with a relatively higher prevalence in summer. (
  • In September 2018, a high positive rate of human adenovirus HAdV was occurred among hospitalized children in the Children's Hospital Affiliated to the Capital Institute of Paediatrics in Beijing. (
  • Adhikary AK, Banik U, Okabe N, Fujimoto T (2011) Molecular characterization of human adenovirus type 8 (HAdV-8), including a novel genome type detected in Japan. (
  • We recently found that human alpha-defensins inhibit human adenovirus (HAdV) by preventing virus uncoating and release of the endosomalytic protein VI during cell entry. (
  • The purpose of this study is to document the different types HAdV circulating in Cameroon in children with acute respiratory infections. (
  • This study reported HAdV species and types detected in children with acute respiratory infections in Cameroon between September 2011 and July 2014. (
  • A study by McMorrow and colleagues shows that HAdV was detected in 6% of 834 deaths in patients with severe respiratory infections recorded across eight African countries [ 6 ]. (
  • According to their tissue tropism, the various HAdV types are responsible of a wide range of human diseases. (
  • To date, there is no antiviral treatment approved against HAdV infections. (
  • The epidemiology, clinical presentation, pathogenesis, vaccination and treatment of HAdV infections depend on the viral type implicated. (
  • The purpose of this work was to acquire an overview of the infectious cycle of HAdV-41 in permissive HEK 293 cells and compare it to that observed with the prototype of the genus, Human adenovirus C HAdV-2. (
  • After 60 h of infection , the export of viral proteins from the infected cell to the extracellular milieu was observed, with a pattern similar to that previously described for HAdV-2 penton-base trafficking after 30 h of infection . (
  • HAdV-41 had a non-lytic cycle and the infection spread from the first infected cell to its neighbours. (
  • The results observed for HAdV-41 infection in HEK 293 cells show how different this virus is from the prototype HAdV-2 and provides information for the development of this vector for use in gene therapy . (
  • Human adenoviruses (HAdV) play an important role in the etiology of severe acute lower respiratory infection , especially in immunocompromised individuals. (
  • HSCT patients presented significantly higher prevalence of HAdV infection . (
  • Background:Respiratory infections caused by adenovirus (HAdV) are common year round. (
  • HAdV types 40 and 41 cause enteric infections in infants worldwide. (
  • Using a library of hamster cells expressing specific human integrins, along with recombinant soluble penton base from HAdV type 41 and commercially available soluble laminins, we identified laminin-binding integrins as co-receptors for entry and infection of human intestinal HT-29 cells by the enteric HAdVs. (
  • By performing cell binding and infection experiments, we have found that the receptor for the short fiber of HAdV-52 is sialic acid-containing glycans and the long fiber receptor is CAR although most of the binding was dependent on sialic acid-containing glycans. (
  • Adenovirus pneumonia among immunocompetent adults is still relatively infrequent and therefore attracts considerable attention ( 4 ). (
  • He was given a diagnosis of adenovirus pneumonia, acute heart failure, and respiratory failure that required veno−venous extracorporeal membrane oxygenation during December 14−19. (
  • A case of lower respiratory tract infection (LRTI) was defined as physician-diagnosed pneumonia, an abnormal chest radiograph, or rales or wheezing on pulmonary auscultation in any student. (
  • Li QG, Zheng QJ, Liu YH, Wadell G (1996) Molecular epidemiology of adenovirus types 3 and 7 isolated from children with pneumonia in Beijing. (
  • The concept of "acute lower respiratory tract infection" (ALRTI) has emerged and it is becoming increasing evident from a number of studies that the infectious base of both acute pneumonia (AP) and acute bronchiolitis in children has a mixed etiology of microorganisms. (
  • For example, cases of herpes simplex virus (HSV) encephalitis, esophagitis orgastritis, cytomegalovirus (CMV) colitis, adenovirus hepatitis or pneumonitis, recurrent or persistent skin infections caused by HSV or varicella zoster virus (VZV), severe warts caused by human papillomavirus (HPV), recurrent respiratory papillomatosis caused by HPV, severe influenza or respiratory syncytial virus pneumonia, and progressive multifocal leukoencephalopathy (PML) due to JC polyomavirus have been described in apparently immunocompetent patients. (
  • However, adenoviruses can cause severe, often fatal pneumonia or bronchiolitis. (
  • Symptoms of respiratory illness caused by adenovirus infection range from the common cold syndrome to pneumonia , croup , and bronchitis . (
  • 3. Pneumonia in children can be caused by RSV, parainfluenza virus, adenovirus, and varicella-zoster virus (VZV). (
  • Respiratory illness symptoms caused by adenovirus infection range from common cold symptoms, pharyngitis, and rhinitis, to bronchitis or pneumonia. (
  • Some infections can cause other illnesses, such as bronchitis (inflammation of the windpipe and main airways), pneumonia (inflammation of the lungs), skin rash, conjunctivitis (pink eye), bladder infection, or bowel infection. (
  • Complications can include ear infections, pneumonia, or meningitis (inflammation of the brain and spinal cord). (
  • In most cases, adenoviruses do not cause any symptoms or signs, but in some people, they cause a range of illnesses including respiratory infections like the common cold , pinkeye , pneumonia , diarrhea , and inflammation of the bladder, intestines , or nervous system . (
  • Difficulty breathing may be a sign of a serious lung infection (pneumonia) that can lead to death. (
  • Vaccine has been developed for preventing uncommon cold or human adenovirus type-3 which is associated with illnesses such as conjunctivitis, upper respiratory infections, pneumonia and gastrointestinal disease. (
  • Pneumonia can strike anytime, but it usually shows up in winter and spring, often after a cold or other upper respiratory infection. (
  • Pneumonia is a general term for infection of the lungs. (
  • An older baby or child might develop pneumonia as the result of other bacterial or viral infections. (
  • Treatment for pneumonia depends on the type of infection your child has. (
  • Secondary pneumococcal pneumonia is a serious complication during and shortly after influenza infection. (
  • We established a mouse model to study postinfluenza pneumococcal pneumonia and evaluated the role of IL-10 in host defense against Streptococcus pneumoniae after recovery from influenza infection. (
  • Mice recovered from influenza infection were highly susceptible to subsequent pneumococcal pneumonia, as reflected by a 100% lethality on day 3 after bacterial infection, whereas control mice showed 17% lethality on day 3 and 83% lethality on day 6 after pneumococcal infection. (
  • In conclusion, mild self-limiting influenza A infection renders normal immunocompetent mice highly susceptible to pneumococcal pneumonia. (
  • Although influenza alone may lead to pneumonia, secondary bacterial infections during and shortly after recovery from influenza infections are much more common causes of pneumonia ( 2 ). (
  • The severity of secondary bacterial pneumonia during or shortly after influenza infection is determined by a complex interaction among virus, bacteria, and host. (
  • Replication-deficient human adenovirus type 5 (Ad5) can be produced to high titers in complementing cell lines, such as PER.C6, and is widely used as a vaccine and gene therapy vector. (
  • Ennis, in highlighting the ingredients of the vaccine, said that these include the adenoviral vector, which is an adenovirus. (
  • Ennis cited the example of the human papillomavirus (HPV) vaccine, which persons had suggested could cause infertility in the girls to whom it was administered, pointing out that many of those girls are now women who are pregnant and having children. (
  • The vaccine used an adenovirus, which normally causes the common cold, to enable the vaccine therapy to travel around the body. (
  • Preliminary results of the vaccine trial showed that people who had previously been infected with the adenovirus used in the trial had a significantly higher risk of being infected with HIV following the vaccine compared to people who were given a placebo. (
  • Our research suggests that the adenovirus-based HIV vaccine effectively instructs the cells that HIV infects to gather round exactly where HIV is likely to be introduced. (
  • Updated prevalence of upper respiratory tract infection, acute otitis media, and lower respiratory tract infection in American infants in the pneumococcal conjugate vaccine era. (
  • Vaccines include a first-generation inactivated vaccine against several adenovirus types and a non-attenuated oral vaccine against adenovirus types 4 and 7. (
  • Questions and answers about Adenoviruses and adenovirus vaccine. (
  • Additionally, there is a U.S. Food and Drug Administration (FDA) approved/licensed vaccine for adenovirus types 4 and 7. (
  • Adenovirus types 4 and 7 can be prevented with a single vaccine dose administered as two live, oral enteric-coated tablets (type 4 - white tablet, type 7- light peach tablet). (
  • There is no vaccine generally available to prevent adenovirus infection. (
  • There is no vaccine available for the general public, although a vaccine against two types of adenovirus is available for U.S. military personnel. (
  • There is currently no adenovirus vaccine available to the general public. (
  • A vaccine specific for adenovirus types 4 and 7 was approved by the U.S. Food and Drug Administration in March 2011, for use only in U.S. military personnel who may be at higher risk for infection from these two adenovirus types. (
  • Adenovirus 11 is most commonly recognized as a cause of hemorrhagic cystitis, acute hemorrhagic conjunctivitis, and illnesses among immunocompromised persons (1,5) and has rarely been associated with ARD in military trainees or in any other immunocompetent adult population (6). (
  • BACKGROUND: Adenoviruses are known to cause several human diseases including acute febrile respiratory syndromes, epidemic conjunctivitis and gastroenteritis. (
  • Apart from respiratory involvement, illnesses and presentations of adenovirus include gastroenteritis , [1] conjunctivitis , cystitis , and rash illness. (
  • Epidemics of febrile disease with conjunctivitis are associated with waterborne transmission of some adenovirus types, often centering on inadequately chlorinated swimming pools and small lakes. (
  • Maintaining adequate levels of chlorination is necessary for preventing swimming pool-associated outbreaks of adenovirus conjunctivitis. (
  • citation needed] Pharyngoconjunctival fever is a specific presentation of adenovirus infection, manifested as: high fever that lasts 4-5 days pharyngitis (sore throat) conjunctivitis (inflamed eyes, usually without pus formation like pink eye) enlargement of the lymph nodes of the neck headache, malaise, and weakness Incubation period of 5-9 days It usually occurs in the age group 5-18. (
  • Keeping adequate levels of chlorine in swimming pools is important to prevent outbreaks of conjunctivitis caused by adenovirus. (
  • Viral conjunctivitis is often associated with an infection of the upper respiratory tract, a common cold, or a sore throat. (
  • Viral conjunctivitis manifests as a fine, diffuse pinkness of the conjunctiva, which is easily mistaken for a ciliary infection of the iris ( iritis ), but corroborative signs on microscopy , particularly numerous lymphoid follicles on the tarsal conjunctiva, and sometimes a punctate keratitis are seen. (
  • Human adenoviruses (HAdVs) cause respiratory illnesses, epidemic conjunctivitis and infantile gastroenteritis. (
  • Patients with adenoviral conjunctivitis may give a history of recent exposure to an individual with a red eye at home, school, or work, or they may have a history of recent symptoms of an upper respiratory tract infection. (
  • Kam KY, Ong HS, Bunce C, Ogunbowale L, Verma S. Sensitivity and specificity of the AdenoPlus point-of-care system in detecting adenovirus in conjunctivitis patients at an ophthalmic emergency department: a diagnostic accuracy study. (
  • Kimura R, Migita H, Kadonosono K, Uchio E. Is it possible to detect the presence of adenovirus in conjunctiva before the onset of conjunctivitis? (
  • Rapid Tests Diagnose Dry Eye, Adenovirus Conjunctivitis. (
  • Strict attention to good infection-control practices, including contact and droplet precautions is effective for stopping nosocomial outbreaks of adenovirus associated disease. (
  • Outbreaks of adenovirus infection can occur in anyone at any time of year. (
  • What Are Reported Outbreaks of Adenovirus Infection? (
  • Outbreaks of adenovirus infection can occur throughout the year. (
  • But the underlying mechanisms for this enhancement of viral infection are not completely clarified. (
  • To study possible immune defects that may be linked to a particular severe viral infection. (
  • Relatives of the participants with a severe viral infection may also participate in the study. (
  • At the Clinical Center, participants will be treated with the best available therapy for the particular viral infection, and researchers will monitor how the infection responds to the treatment. (
  • In immunocompromised individuals, the immunomodulatory activities of MSCs have raised safety concerns regarding the greater risk of primary viral infection and viral reactivation, which is a major cause of mortality after allogeneic transplantation. (
  • Patients with KD commonly have a concurrent respiratory viral infection. (
  • Sometimes, bacteria can infect the ears or sinuses during this viral infection - this is known as a secondary bacterial infection - and can be treated with antibiotics . (
  • Ten children have died in the past few weeks as a result of a common viral infection that typically causes mild symptoms. (
  • Safety netting versus overtreatment in paediatrics: viral infection or incomplete Kawasaki disease? (
  • However, the mechanism by which DDRs are activated by viral infection is poorly understood. (
  • [2] The viral infection may occur along with other symptoms of a common cold . (
  • Natural killer (NK) cells are known for their ability to directly lyse host cells that express an altered cell surface phenotype following a viral infection, malignant transformation, or stress reaction. (
  • Human adenovirus 7d, a genomic variant with no reported circulation in the United States, was isolated from 2 adults with severe respiratory infections in Illinois. (
  • In particular, respiratory infections with human adenovirus 7 (HAdV7) have a well-documented association with severe clinical manifestations, nosocomial transmission, prolonged hospitalizations, pulmonary sequela, and deaths ( 1 − 6 ). (
  • We report characterization of adenovirus strains isolated from 2 adults in the same family who had severe respiratory infections in Illinois, USA, during December 2014. (
  • Admission chest radiographs of 2 adults with severe infections with adenovirus type 7 in family, Illinois, USA, 2014. (
  • Adenovirus morbidity and mortality associated with nonmilitary congregate settings are less well described, although severe morbidity and mortality have been documented among immunocompromised patients ( 5 ). (
  • Individuals of any age who have or have had a diagnosis of a virus infection that physicians consider to be unusually severe, prolonged, or difficult to treat. (
  • While a variety of case reports have described severe viral infections in immunocompetent hosts, the pathogenesis of the vast majority of these cases is not understood, and therapy can be unsuccessful. (
  • Severe acute respiratory illness has been noted in association with Ad1 through Ad8, Ad19, Ad21, Ad35, and others, but outbreaks of severe infections in healthy children are most frequently reported with Ad7, followed by Ad3 and Ad21 ( 11 , 16 , 20 , 29 ). (
  • Epidemics of severe acute respiratory illness caused by these adenovirus types have often been noted among infants of Asian descent and native populations in New Zealand, Canada, and northern Finland. (
  • These diseases associated with adenovirus infection affect adults and are usually more severe in infants and children. (
  • Patients with compromised immune systems are especially susceptible to severe complications of adenovirus infection. (
  • for example, infection with adenovirus 7 acquired by inhalation is associated with severe lower respiratory tract disease, whereas oral transmission of the virus typically causes no or mild disease. (
  • These findings indicate that in hamsters, pathology resulting from intravenous infection with adenoviruses is caused mostly by replication in hepatocytes and not by the abortive infection of Kupffer cells and the following cytokine storm.IMPORTANCE Immunocompromised human patients can develop severe, often lethal adenovirus infections. (
  • The implementation of molecular methods for adenovirus diagnosis has increased their awareness in the clinical setting as severe and emerging pathogens. (
  • Severe infections and fatal cases are more frequent in immunocompromised patients such as stem cell transplant recipients. (
  • Young infants and patients with compromised immune systems are more susceptible to severe complications from adenovirus infection. (
  • Adenoviruses can cause mild to severe illness, though serious illness is less common. (
  • People with weakened immune systems, or existing respiratory or cardiac disease, are at higher risk of developing severe illness from an adenovirus infection. (
  • 3 8 The following case of intermittent prolonged fever and rash in a 4-year-old boy illustrates the difficulty clinicians face to treat prophylactically when a common presentation of upper respiratory tract infection partially fulfils the diagnostic criteria for a more severe illness such as incomplete KD (iKD). (
  • Adenovirus type 7 associated with severe and fatal acute lower respiratory infections in Argentine children. (
  • An adenovirus type-2 was isolated from peripheral blood lymphocytes and throat washings from a patient with severe chronic active Epstein-Barr virus infection. (
  • Primary infection with this pathogen is usually less severe than secondary infection ( 5 ). (
  • This report summarizes the epidemiologic and clinical features of this outbreak and discusses the change in availability of adenovirus vaccines for military use. (
  • Furthermore, our results highlight the potential of using these non-human primates as models for testing safety and efficacy of candidate adenovirus vaccines prior to clinical trials in humans. (
  • Adenoviruses represent a particularly promising class of oncolytic viral vaccines. (
  • The researchers say their findings are a warning for scientists developing adenovirus vaccines against other diseases, as the same effect occurs with other, perhaps all, adenovirus subtypes. (
  • Scientists use adenoviruses in all sorts of vaccines and we did not expect this result. (
  • Scientists are currently developing adenovirus-based vaccines to protect people against TB and malaria as well as HIV, but they may have to rethink these vaccines if the effect we describe in our new paper is a problem for all of them," added Dr Patterson. (
  • The authors say this means all subtypes of adenovirus are likely to be unsuitable in HIV vaccines. (
  • Adenovirus vaccines are live-virus vaccines approved for one-time use in new military members, ages 17 to 50 years. (
  • Very little is known about the human cellular immune response to Ebola virus infection, and this lack of knowledge has hindered development of effective therapies and vaccines. (
  • Background Human Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. (
  • Thounaojam AD, Balakrishnan A, Mun AB (2016) Detection and molecular typing of human adenoviruses associated with respiratory illnesses in Kerala. (
  • In fact, adenovirus infections, which are common in every country and in every season, are the culprit in up to 10% of all febrile illnesses in young children and virtually 100% of adults have antibodies in their blood signaling a prior infection. (
  • Adenoviruses cause a wide range of illnesses, depending on the virus type. (
  • Human adenoviruses (HAdVs) are common human pathogens encoding a highly abundant histone-like core protein, VII, which is involved in nuclear delivery and protection of viral DNA as well as in sequestering immune danger signals in infected cells. (
  • In addition, we show that measles virus and vesicular stomatitis virus infections reduce the MKRN1 protein accumulation in the recipient cells. (
  • Protein VII is expressed during the late phase of infection, and it accumulates as a precursor polypeptide, designated the pVII protein ( 4 ). (
  • RESULTS -Ad-36 and Ad-2 infections were confirmed by the presence of respective viral mRNA and protein expressions. (
  • These findings suggest a mechanism in which defensin binding to critical sites on the AdV capsid prevents vertex removal and thereby blocks subsequent steps in uncoating that are required for release of protein VI and endosomalysis during infection. (
  • Adenovirus E1A induces cell proliferation, oncogenic transformation and promotes viral replication through interaction with p300/CBP, TRRAP/p400 multi-protein complex and the retinoblastoma (pRb) family proteins through distinct domains in the E1A N-terminal region. (
  • The feasibility of using adenovirus-mediated human oligopeptide transporter (hPEPT1) gene transfer to achieve peptide drug delivery to the brain across the blood-brain barrier was tested by examining the accumulation of model peptides in a rat brain endothelial cell line (RBEC1) and rat brain after transduction with a recombinant adenovirus encoding hPEPT1-enhanced yellow fluorescent protein fusion gene (AdhPEPT1-EYFP). (
  • The human involucrin protein is a specific product of keratinocyte differentiation, which is selectively expressed in the suprabasal epidermal layers. (
  • Microbial infection) Interacts with adenovirus E3 14.7 kDa protein. (
  • This protein forms part of the shaft of the fibres or spikes by which adenoviruses attach to receptors on cells during the infection process. (
  • Human cytomegalovirus (HCMV) infection induces a DDR centered on the activation of ataxia telangiectasia mutated (ATM) protein kinase. (
  • E2F1, but not E2F2 or E2F3, promotes the accumulation of γH2AX during HCMV infection or IE protein expression. (
  • Heterogeneous nuclear ribonucleoprotein U-like protein 1 is a protein that in humans is encoded by the HNRNPUL1 gene. (
  • This protein binds specifically to adenovirus E1B-55kDa oncoprotein. (
  • HNRPUL1 also participates in ATR protein kinase signalling pathways during adenovirus infection. (
  • Adenovirus (Ad) vectors are promising for gene therapy of glioma due to their ability to achieve efficient gene transfer upon intratumoral administration. (
  • These findings show that preexisting immunity severely hampers accurate dose control, since human individuals differ in their NA against Ad5-based vectors. (
  • Further, adenovirus-based vectors are frequently used as experimental viral therapeutic agents. (
  • Recombinant adenovirus (Ad) gene transfer vectors are effective at transferring exogenous genes to a variety of cells and tissue types both in vitro and in vivo. (
  • To develop a broader understanding of Ad vector-mediated induction of endogenous gene expression, genes induced by first-generation E1 - E4 + Ad vectors in primary human umbilical vein endothelial cells were identified by cDNA subtraction cloning. (
  • These mechanisms have been identified upon addressing the questions of how to de- and retarget adenovirus-based vectors for human gene and cancer therapy, but the newly identified mechanisms also suggest that the role of body fluids and their components may also be of importance for natural, primary infections. (
  • This review will summarize antibody responses against natural AAV infections, as well as AAV gene therapy vectors and their impact in the clinical development of AAV vectors for gene therapy. (
  • In this review we will provide an overview of humoral responses to natural infection with AAV and to therapeutic AAV vectors in small and large animal models including humans. (
  • The source of such infections is often difficult to assess, that is, whether acquired as a primary infection, exposure to a pathogen in the transplanted organ, or reactivation of an endogenous latent infection. (
  • Epigenetic factors may also regulate persistent adenovirus infection and reactivation in lymphoid tissues. (
  • And there are concerns, thus far unproven, of the possibility of herpes-like reactivation of prior adenovirus infection as a result of the extreme immune suppression required for bone marrow transplantation. (
  • Acute respiratory disease (ARD), first recognized among military recruits during World War II, can be caused by adenovirus infections during conditions of crowding and stress. (
  • Respiratory adenovirus infection among military recruits is a serious problem, in some cases requiring hospitalization of the patient. (
  • Adenoviruses can also cause epidemic keratoconjunctivitis (EKC) and are considered to be responsible for an outbreak of respiratory disease among military recruits in 1997. (
  • Military recruits are at a higher risk of respiratory infection than their civilian counterparts. (
  • Further studies demonstrated that GM-CSF and IL-4 can promote Ad infection by up-regulating the expression of scavenger receptor 1 (SR-A) and integrins αVβ5 receptor of CD14+ cells. (
  • Thus, chronic infection of lymphoid cells by some adenoviruses is maintained by at least two mechanisms: cell-to-cell spread of virus in the absence of antibody and intracellular persistence of infectious virus in the presence of antibody. (
  • Ad entry is dependent upon the expression of fiber receptors, such as coxsackie/adenovirus receptor, and αv integrins on the target cells for binding and internalization, respectively. (
  • Normal human bronchial epithelial cells were infected with SV40 virus or an adenovirus 12-SV40 hybrid virus, or transfected via strontium phosphate coprecipitation with plasmids containing the SV40 early region genes. (
  • these cells had extended culture lifespans compared to normal human bronchial epithelial cells. (
  • High-titer, purified E1-lacking Ad35 virus was subsequently tested in vitro and in vivo, showing that a recombinant Ad35 vector successfully circumvents anti-Ad5 NA and that the tropism of Ad35 is favorable, compared to Ad5, on human dendritic cells, smooth muscle cells (SMC), and synoviocytes, considered important target cells for treatment or prevention of disease. (
  • All human adenovirus types, Ad1 through Ad51 (a kind gift from Jan de Jong, University of Rotterdam, Rotterdam, The Netherlands), were inoculated on PER.C6 cells. (
  • Chiu concluded that staff members had been exposed to the new virus, and that the virus may have jumped from baboon to human, an idea also supported by follow-up experiments in which laboratory strains of simian adenovirus C efficiently infected both human and baboon cells. (
  • In this study, we present evidence that adhesion to some common matrix constituents has a profound impact on the transcription, secretion, and storage of insulin by human β-cells. (
  • Based on these findings, we contend that integrin-dependent adhesion and signaling in response to certain matrices can have a significant negative impact on insulin production by primary human β-cells. (
  • A complex matrix rich in laminin-5 (804G-matrix) has been shown to potentiate insulin secretion in response to glucose ( 11 , 12 ), and we have shown that common constituents of basement membranes, including collagen IV, induce significant insulin secretion by human fetal β-cells ( 4 ). (
  • The purpose of this study was to define the impact of individual matrix interactions on insulin production by cultured human β-cells. (
  • We show that adhesion of primary human β-cells to substrates such as vitronectin and collagen IV results in a dramatic loss of insulin content and insulin production. (
  • Infection of hUlnan cells by bovine adenovirlls type 2 (BAV2) is abortive. (
  • To obtain a better understanding of this pllenomel1011, and in particular to identify Wllich steps in the viral replicative cycles are altered dllring this virlls-host cells interaction, we have llndertaken a detailed study of BAV2 infections of the nonpennissive hUlnan IIeLa cells. (
  • Using autoradiography and 3H-thymidine-labeled vvhole virus particles for infection of HeLa cells, vve determined that viral attachluent appears normal. (
  • This further suggests that the abortive infection b:y BAV2 could be attributed to failure of EIA to express dlle to a nonfllnctional prOlTIoter in hlunan cells. (
  • Thus we speClllated that abortive infection of HeLa cells by adenoviruses may be averted by providing EtA functions in trans. (
  • This could ilnply that El is necessary but not sufficient to avert the failllre ofBAV2 to undergo productive infection ofhulnan cells. (
  • We determined the ability of Ad-36 to increase glucose uptake by human primary skeletal muscle (HSKM) cells. (
  • CONCLUSIONS -Ad-36 infection increases glucose uptake in HSKM cells via Ras-activated PI 3-kinase pathway in an insulin-independent manner. (
  • The following experiments showed that Ad-36 activates PI 3-kinase and increases glucose uptake in nondiabetic and diabetic human skeletal muscle (HSKM) cells. (
  • During productive infection, CtBP-E1A interaction enhances viral replication in human cells. (
  • Between the two CtBP family proteins, CtBP2 appears to restrict viral replication more than CtBP1 in human cells. (
  • The interaction enhances viral replication in human cells. (
  • Accordingly, immunohistochemistry with specific antibodies shows that HMGCS2 is expressed mainly in differentiated cells of human colonic epithelium. (
  • Our working hypothesis is that adenoviral E l A D N A persists in airway epithelial cells following respiratory infections and is capable of amplifying cigarette smoked-induced airway inflammation. (
  • Using optimal conditions established for this indirect in situ PCR on paraffin embedded sections of Graham 293 cells, this procedure was performed on paraffin embedded sections of guinea pig lungs 20 days after the resolution of an acute infection with adenovirus 5 when no replicating virus could be recovered from these lungs (Vitalis, et al. (
  • Our findings indicate that indirect in situ P C R allows the detection of 4 to 5 copies of adenovirus E l A D N A in Graham 293 cells. (
  • Localization of adenovirus E l A D N A in alveolar epithelial cells could have important implications regarding the regulation of proinflammatory agents that mediate neutrophil migration into the alveolar walls. (
  • We demonstrate that replication in permissive cells in a susceptible host animal is a major part of the mechanism by which systemic adenovirus infection induces pathology, as opposed to a chiefly immune-mediated pathology observed in non-susceptible hosts. (
  • Our results show that a broad range of human carcinoma cells will support EnAd replication, but not murine carcinoma cells. (
  • Murine cells can be readily modified to express surface human CD46, one of the receptors for group B adenoviruses, allowing receptor-mediated uptake of EnAd particles into the murine cells and expression of CMV promoter-driven transgenes. (
  • Although the early E1A mRNA was expressed in murine cells at levels similar to human cells, adenovirus E2B and Fibre mRNA expression levels were hampered and few virus genomes were produced. (
  • Together, these results indicate that there may be major differences in the early stages of replication of group C and B adenoviruses in murine cells, and that the block to the life cycle of B adenoviruses in murine cells occurs in the early stage of virus replication, perhaps reflecting poor activity of Ad11p E1A in murine cells. (
  • In contrast to that observed in endothelial cells, the Ad vector-mediated induction of gene expression was not found following Ad vector infection of primary human dermal fibroblasts or human alveolar macrophages. (
  • Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen. (
  • Infection with Ad.DF3-E1/CMV-TNF was associated with selective replication and production of TNF in cells that express MUC1. (
  • Adenoviruses possess a linear dsDNA genome and are able to replicate in the nucleus of vertebrate cells using the host's replication machinery. (
  • Ad/GFP release was estimated with PCR and infection of 293 cells with the supernatant. (
  • Today's study suggests that after receiving the trial vaccination, people who had previously built up immunity to the adenovirus had an influx of immune cells called CD4 T-cells homing in on their mucous membranes, as these cells prepared to fight off a new adenovirus infection. (
  • HIV naturally infects CD4 T-cells, so this inadvertently provided HIV with an abundance of potential new homes at the sites where the virus would naturally enter the body during sexual intercourse, thereby increasing people's risk of infection. (
  • The results also showed that CD4 cells can recognize and react to another distinct subtype of adenovirus, regardless of which subtype the person was infected with initially. (
  • Adenoviruses develop within the nuclei of infected cells, where they are often observed packed in an apparently crystalline arrangement. (
  • Most adenoviruses bind directly to the coxsackie and adenovirus receptor (CAR) on target cells in vitro, but recent research has shown that adenoviruses can also use soluble components in body fluids for indirect binding to target cells. (
  • Here we demonstrate that plasma, saliva, and tear fluid promote binding and infection of adenovirus type 5 (Ad5) in respiratory and ocular epithelial cells, which corresponds to the natural tropism of most adenoviruses, and that plasma promotes infection by Ad31. (
  • a decrease in the blood cells that fight infection (neutropenia). (
  • Here we show that HCMV replication is compromised in cells with inactivated or depleted ATM and that ATM is essential for the host DDR early during infection. (
  • Infections with parasites of the genus Leishmania lead to a rapid, but transient activation of natural killer (NK) cells. (
  • In human cutaneous and VL, the functional importance of NK cells is suggested by reports that demonstrate (1) a direct activation or inhibition of NK cells by Leishmania promastigotes, (2) the suppression of NK cell numbers or activity during chronic, non-healing infections, and (3) the recovery of NK cell activity following treatment. (
  • This review aims to provide an integrated view on the migration, activation, inhibition, function, and therapeutic modulation of NK cells in experimental and human leishmaniasis. (
  • It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. (
  • Tumor necrosis factor-α is an important mediator of inflammation and it contributes to the pathogenesis of a variety of conditions, including rheumatoid arthritis, Crohn's disease, and many types of infections ( 1 , 2 ). (
  • Chapter 8, Cytomegalovirus: Sections on pathogenesis of CMV in relation to organ transplantation and mononucleosis, as well as sections on the risk and features of con- genital infection and disease, have been expanded. (
  • Thus, it is imperative that we investigate the pathogenesis of adenoviruses in a permissive animal model. (
  • Akello JO, Kamgang R, Barbani MT, Suter-Riniker F, Leib SL, Ramette A (2020) Epidemiology of human adenoviruses: a 20-year retrospective observational study in hospitalized patients in Bern, Switzerland. (
  • Objective:To understand the prevalence and molecular epidemiology of respiratory adenovirus circulating in Taiwan for the. (
  • A Molecular Epidemiology Survey of Respiratory Adenoviruses Circulating in Children Residing in Southern Palestine. (
  • A molecular epidemiology survey was performed in order to establish and document the respiratory adenovirus pathogen profiles among children in Southern Palestine. (
  • IMPORTANCE Human adenoviruses (HAdVs) are common pathogens causing a wide range of diseases. (
  • Human adenoviruses (HAdVs) are common pathogens, and their infections cause a wide range of diseases, including respiratory illness, keratoconjunctivitis, and gastroenteritis ( 1 , 2 ). (
  • However, limited studies are available regarding the epidemiological patterns and diversity of HAdVs types among hospitalized patients with respiratory tract infections (RTIs). (
  • Human adenoviruses (HAdVs) cause a wide range of diseases worldwide, including respiratory infections. (
  • Human adenoviruses (HAdVs) are one of the common pathogens found in acute respiratory infections worldwide. (
  • HAdVs species B, C, and, E are involved in upper and lower acute respiratory tract infections. (
  • Adenovirus infections are endemic, particularly among children, but also may cause epidemics of pharyngoconjunctival fever, keratoconjunctivitis, gastroenteritis, and acute respiratory disease (ARD) among military trainees. (
  • Enteric adenoviruses 40 and 41 cause gastroenteritis, usually in children. (
  • 5-Fluorouracil-related enhancement of adenoviral infection is Coxsackievirus-adenovirus receptor independent and associated with morphological changes in lipid membranes. (
  • Low and high Coxsackievirus- Adenovirus Receptor (CAR) expressing human colon carcinoma cell lines were treated with 5-FU and two E1-deleted adenoviral constructs, one transferring GFP (Ad/CMV-GFP) the other bax (Ad/CEA-bax). (
  • Coxsackievirus and adenovirus receptor, CD46, sialic acid, coagulation factors IX and X, lactoferrin and heparan sulfate are some receptors and molecules which the hexon and fiber proteins (components of the capsid) bind for direct or indirect cellular attachment. (
  • Lion T (2014) Adenovirus infections in immunocompetent and immunocompromised patients. (
  • 2011) Toward an integrated human adenovirus designation system that utilizes molecular and serological data and serves both clinical and fundamental virology. (
  • Viral Infections and Global Change is an indispensable resource for research scientists, epidemiologists, and medical and veterinary students working in ecology, environmental management, climatology, neurovirology, virology, and infectious disease. (
  • Indeed, the field of molecular virology has evolved during the period since their dis- covery, and adenoviruses have played a major role in this development. (
  • The exciting discoveries made with adenoviruses have had such a pro- found effect on knowledge in basic virology, molecular biology, viral ge- netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. (
  • This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. (
  • [8] Strict attention to good infection-control practices is effective for stopping transmission in hospitals of adenovirus-associated disease, such as epidemic keratoconjunctivitis. (
  • Note that this CDC surveillance data reports on multiple epidemic episodes of keratoconjunctivitis in the U.S. over the past several years -- most associated with adenovirus. (
  • Six unrelated outbreaks of epidemic keratoconjunctivitis linked to human adenovirus underscore the importance of infection control measures in ophthalmology, according to the CDC. (
  • Novel human adenovirus causing nosocomial epidemic keratoconjunctivitis. (
  • We report the identification of human Ad35 as a virus with low global prevalence and the generation of an Ad35 vector plasmid system for easy insertion of heterologous genes. (
  • However, recent knowledge on the prevalence of NA towards human adenoviruses worldwide is not available and therefore it is difficult to predict which type would be the best alternative for Ad5. (
  • To date, limited studies have been done to determine the prevalence of adenovirus infection in non-human primates with the goal of developing a non-human primate model that can be used to study the mechanisms of infection. (
  • OBJECTIVE: To determine the prevalence of enteric adenovirus infection in Kenyan non-human primates. (
  • DESIGN: A prospective study to investigate the prevalence of enteric andenovirus infection in captive non-human primates maintained in a colony. (
  • It was found that established human glioma cell lines exhibited differential susceptibility to Ad-mediated gene transfer, which correlated directly with the level of radiolabeled Ad binding and with the expression of coxsackie/adenovirus receptor but not with the expression of αv integrins. (
  • This study characterized the mechanism by which NF-κB family members interact to regulate the human TNF-α gene. (
  • However, ectopically expressed wild-type or dominant-negative (DN) versions of these transcription factors have not been employed to document their importance in the regulation of the TNF-α gene in primary human macrophages. (
  • Recombinant Human Adenovirus Type 5, an E1B gene deleted adenovirus, is known to have a significant antitumor activity. (
  • The DF3/MUC1 gene is aberrantly overexpressed in human breast and other carcinomas. (
  • Therefore, we examined the effects of transferring the cyclin-dependent kinase inhibitor p21 sdi1 gene into human esophageal cancer cell lines as well as normal keratinocytes using an adenovirus vector system. (
  • A multiplex PCR assay was developed by using primers to the fiber gene that could differentiate human adenovirus (Ad) species A through F in a single amplification reaction. (
  • Recombinant adenovirus carrying the human XPA gene was used for in vivo gene therapy in UVB-irradiated skin of such mice. (
  • Thus, efficient adenovirus gene delivery to the skin is a promising tool for reconstitution of specific DNA repair defects in XP patients. (
  • Mice defective in the highly conserved Xpa gene (as well as multiple other XP-mutant mice) have been generated by conventional gene targeting and represent attractive models for the human disease. (
  • Production and purification of adenovirus vector encoding human XPA gene and the EGFP (AdyXPA) was described in ref. 16 . (
  • Sarantis H, Johnson G, Brown M, Petric M, Tellier R (2004) Comprehensive detection and serotyping of human adenoviruses by PCR and sequencing. (
  • Serological detection of adenoviruses in non-human primates maintained in a colony in Kenya. (
  • Antigen detection, polymerase chain reaction assay, virus isolation , and serology can be used to identify adenovirus infections. (
  • Adenovirus detection through nested- PCR assay was higher. (
  • Molecular detection methods for adenovirus. (
  • Simplified detection of the adenovirus in human feces, the adenovirus infection antigen testing kit allows for results within 10 minutes at 99.6% accuracy. (
  • Duplex-PCR assay for the detection of adenovirus and respiratory syncytial virus in nasopharyngeal samples. (
  • The possibility of human adenovirus detection from the conjunctiva in asymptomatic cases during nosocomial infection. (
  • It has been shown in diverse in vivo models that recombinant adenovirus type 5 (Ad5) has potential as a vehicle to transfer genes for treatment or prevention of disease ( 49 , 52 ). (
  • Probable Donor-Derived Human Adenovirus Type 34 Infection in 2 Kidney " by Matthew A. Pettengill, Tara M. Babu et al. (
  • Probable Donor-Derived Human Adenovirus Type 34 Infection in 2 Kidney Transplant Recipients From the Same Donor. (
  • We have recently shown that reduced I Ca,L amplitude in human cAF is associated with increased activity of type 1 (PP1) and type 2 (PP2A) phosphatases. (
  • OBJECTIVE -Human adenovirus type 36 (Ad-36) increases adiposity but improves insulin sensitivity in experimentally infected animals. (
  • Adenovirus type 2, a human adenovirus that is not adipogenic in animals ( 9 ), was used as a negative control. (
  • The purpose of this study is to determine if TACE plus Recombinant Human Adenovirus Type 5 Injection will improve outcome in patients with advanced hepatocellular carcinoma (HCC) not amenable to surgery or local ablative therapy. (
  • In addition, local injection of recombinant human adenovirus type 5 can enhance the effect of antitumor therapies (chemotherapy and radiotherapy). (
  • The hypothesis is that patients with unresectable HCC may benefit from recombinant human adenovirus type 5 in combination with TACE. (
  • A single injection of a type of virus known as adenoviruses can help give up the habit of drinking, a study indicates. (
  • Although epidemiologic characteristics of the adenoviruses vary by type, all are transmitted by direct contact, fecal-oral transmission, and occasionally waterborne transmission. (
  • Adenovirus typing is usually accomplished by hemagglutination-inhibition and/or neutralization with type-specific antisera. (
  • Symptoms of adenoviral urethritis are similar to urethritis of other causes, and can include: pain during sex or urination unusual discharge from the penis inflammation of the urinary meatus Other non-gonococcal urethritis symptoms Although epidemiologic characteristics of the adenoviruses vary by type, all are transmitted by direct contact, fecal-oral transmission, and occasionally waterborne transmission. (
  • This is a particular challenge for group B adenoviruses, which fail to infect even those immunocompetent animal model systems identified as semi-permissive for type 5 adenovirus. (
  • Replication efficiency of Ad.DF3-E1 (open circles), Ad.DF3-E1/CMV (open triangles), Ad.DF3-E1/CMV-TNF (filled diamonds), and wild-type Ad5 (open squares) in human cell lines. (
  • Dechecchi MC , Tamanini A , Bonizzato A and Cabrini G (2000) Heparan sulfate glycosaminoglycans are involved in adenovirus Type 5 and 2‐Host cell interactions. (
  • The researchers measured antibodies against adenovirus type 5 (Ad-5) and adenovirus type 11 (Ad-11) in 20 healthy volunteers to determine who had been infected. (
  • Using type-specific antisera, the isolate was identified as adenovirus type-2. (
  • In addition, both Epstein-Barr virus and adenovirus type-2 genomes were seen in the colonic tissues and spleen. (
  • These results suggest that the combination of Epstein-Barr virus and adenovirus type-2 may be etiologic agents in the development of chronic active Epstein-Barr virus infection in this patient. (
  • Adenoviruses commonly infect humans, causing colds, flu-like symptoms and sometimes even death, but now UC San Francisco researchers have discovered that a new species of adenovirus can spread from primate to primate, and potentially from monkey to human. (
  • What are the symptoms of acute upper respiratory infection? (
  • direct fluorescence assay (DFA) and nested- polymerase chain reaction ( PCR -nested) from patients with acute respiratory infection (ARI) up to 7 days of symptoms onset. (
  • What are the symptoms of adenovirus infection? (
  • The symptoms of adenovirus infection depend on the site of infection. (
  • For respiratory infections, symptoms usually appear 2-14 days after exposure to the virus. (
  • For intestinal tract infections, symptoms usually appear 3-10 days after exposure to the virus. (
  • Doctors usually diagnose adenovirus infection based on the patient's symptoms. (
  • Adenovirus infections are most contagious during the first few days of symptoms. (
  • What Are Signs and Symptoms of an Adenovirus Infection? (
  • This "virus shedding" usually occurs without any symptoms, even though the person can still spread adenovirus to other people. (
  • Most adenovirus infections are mild and may require only care to help relieve symptoms. (
  • What are the types of acute upper respiratory infection? (
  • Who is at risk for acute upper respiratory infection? (
  • How is acute upper respiratory infection diagnosed? (
  • How is acute upper respiratory infection treated? (
  • Respiratory infection caused by group C adenoviruses is a possible independent risk factor for COPD. (
  • The virus replicates to high titers in the liver of these animals after intravenous infection, while respiratory infection results in virus replication in the lung. (
  • Follow‐up of a patient with acute respiratory infection on subsequent dates. (
  • Background: Adenoviruses are the second most prevalent cause of acute lower respiratory infection of viral origin in children under four years of age in Buenos Aires, Argentina. (
  • The purpose of this study was to analyze the clinical features and outcome of acute lower respiratory infection. (
  • In the human promoter, the peroxisome proliferator-activated receptor element and the Sp1-binding site are also present in similar positions ( 14 - 16 ). (
  • It is the co-receptor interaction that stimulates entry of the adenovirus. (
  • All the faecal samples were screened for presence of adenoviruses using a commercial antigen-capture enzyme immunoassay (EIA) kit, this is an enzyme-linked immunosorbent assay (ELISA) kit designed for diagnosis of human enteric adenoviruses in stool samples. (
  • Re-examining the samples many years later, Chiu and his colleagues found antibodies targeted to simian adenovirus C in the human samples. (
  • As a result of natural infections, antibodies to AAV can be found in many animals including humans. (
  • However, we report here that preexisting virus-specific T cell responses also contribute to promoting adenovirus (Ad) infection. (
  • In contrast, adding virus-specific CD3+ T lymphocytes into PBMC samples of Ad-seronegative individuals resulted in a significant increase of infection efficacy. (
  • A nasal swab specimen obtained at admission to NMH was positive for adenovirus B/E by the GenMarkDx eSensor Respiratory Virus Panel (Genmark Diagnostics, Inc., Carlsbad, CA, USA). (
  • A BAL specimen obtained on December 17 was positive for adenovirus B/E by the GenMarkDx eSensor Respiratory Virus Panel. (
  • Chronic infection with adenovirus types 5 and 6 was established in primary mononuclear leukocytes from human umbilical cord blood and in Epstein-Barr virus (EBV)-transformed B lymphocytes from human umbilical cord blood and from woolly monkey blood. (
  • Infection in cultures of EBV-transformed lymphocytes from woolly monkey blood was obliterated by exposure to antibody, but EBV-transformed lymphocytes from human umbilical cord blood contained small amounts of virus for prolonged periods that restored infection in the culture when antibody was removed. (
  • All three developed a mild, "cold-like" respiratory illness and an antibody response to the infection, but were able to eliminate the virus within 12 days. (
  • This new virus likely formed when an existing adenovirus recombined with another, generating a new strain that was highly virulent to baboons. (
  • E4-ORF3 clears the way for adenovirus to proliferate by deactivating genes that help the cell defend itself against the virus. (
  • In addition to informing the mechanism of defensin-mediated neutralization of a non-enveloped virus, these studies provide insight into the mechanism of AdV uncoating and suggest new strategies to disrupt this process and inhibit infection. (
  • Some virus infections like influenza are cleared from the body, and others such as the chicken pox virus remain in the body in an inactive state. (
  • Researchers have discovered some reasons why a person may not be able to clear an infection caused by a virus. (
  • Some persons have changes in the genes that involve the immune system that result in the inability to properly control infection with a particular virus. (
  • About 50% of corona virus infections result in clinical illness. (
  • By understanding the mechanisms through which adenovirus manipulates host chromatin, we will understand new aspects of this ubiquitous virus and shed light on previously unknown aspects of chromatin biology. (
  • Since adenovirus can be excreted for prolonged periods, the presence of virus does not necessarily mean it is associated with disease. (
  • Entry of adenoviruses into the host cell involves two sets of interactions between the virus and the host cell. (
  • When a virus manages to overpower the body's immune system, infection occurs. (
  • This is a virus that causes infection in some animals. (
  • Skin infections: Rash site and, depending on the virus, serum and urine b. (
  • 2. Croup and bronchitis can be caused by influenza virus, parainfluenza virus, RSV, and adenovirus. (
  • But one hazard that is rarely discussed is the dramatic rise in the number and magnitude of tropical virus outbreaks among human populations. (
  • Adenovirus , any virus belonging to the family Adenoviridae. (
  • Adenovirus is contagious and spreads by contact with infected people, breathing air that contains droplets produced by coughing or sneezing by an infected person, or touching a surface contaminated with the virus. (
  • Sometimes the virus can be shed (released from the body) for a long time after a person recovers from an adenovirus infection, especially among people who have weakened immune systems. (
  • Infections by at least one respiratory virus were confirmed by reverse transcription PCR (RT-PCR) in 123 of 246 (50%) participants. (
  • Of these 123 participants, 111 (90%) were infected by human (seasonal) coronavirus ( n = 17), influenza virus ( n = 43) or rhinovirus ( n = 54) (Extended Data Figs. 1 and 2 ), including one participant co-infected by both coronavirus and influenza virus and another two participants co-infected by both rhinovirus and influenza virus. (
  • Background: Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is associated with reduced bone mineral density (BMD) and increased fracture rates, particularly in women. (
  • Virus particles with adenovirus morphology were seen by electron microscopy. (
  • In this study, we characterize the human immune response to Ebola virus infection in four patients. (
  • We define the kinetics of T- and B-cell activation, and determine which viral proteins are targets of the Ebola virus-specific T-cell response in humans. (
  • Four Ebola patients received care at Emory University Hospital, presenting a unique opportunity to examine the cellular immune responses during acute Ebola virus infection. (
  • During combined viral/bacterial infections, the severity of the infection can increase due to enhanced virulence of the influenza virus facilitated by bacterial proteases ( 6 ). (
  • However, the host remains more susceptible to bacterial infections for several weeks after clearance of the influenza virus, which indicates that the enhanced susceptibility is not only due to an increased viral virulence ( 7 ). (
  • We observed complete recovery of defective DNA repair in mouse embryo fibroblasts (MEF) in culture after infection with the virus. (
  • Of the 334 samples, 266 samples (78%) were positive at least for one virus, including 107 (42%) cases of multiple infections. (
  • Dhurandhar's particular interest is in the relationship between obesity and a common virus, the adenovirus. (
  • ARD is most often associated with adenovirus types 4 and 7 in the United States. (
  • Fluorescence Quantitative PCR was performed to detect adenovirus as well as other common ARI-related pathogens. (
  • In addition, epidemiological features and co-infection with other human respiratory pathogens were investigated and analyzed. (
  • Adenoviruses are human pathogens that commonly infect the respiratory and gastrointestinal tracts (1). (
  • 1995) Evolving pathogens in allogeneic bone marrow transplantation: increased fatal adenoviral infections. (
  • Influenza infection is known to increase adherence of and subsequent colonization with bacterial respiratory pathogens. (
  • Beyond the role of chromatin in the viral replication cycle, we discuss the nature of persistent viral genomes in lymphoid tissue and cell lines, and the potential contribution of epigenetic signals in maintaining adenovirus in a quiescent state. (
  • Some types are capable of establishing persistent asymptomatic infections in tonsils, adenoids , and intestines of infected hosts, and shedding can occur for months or years. (
  • These mechanisms, which are way beyond the scope of this post, may also play a role in the persistent shedding of adenoviruses for weeks after a patient has recovered from the acute illness. (
  • AdVs are capable of evading the immune response and they can produce persistent or latent infections. (
  • Some types can establish persistent asymptomatic infections in tonsils, adenoids, and intestines of infected individuals, and viral shedding can occur for months or years. (
  • The ATM-dependent DDR is detected as discrete, nuclear γH2AX foci early in infection and can be activated by IE proteins. (
  • An arginine-glycine-aspartic acid amino acid motif is present in most but not all adenovirus penton base proteins and mediates interaction with αv integrins, resulting in internalization. (
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (
  • Visit the Centers for Disease Control and Prevention website at . (
  • In contrast to a replication-incompetent adenoviral vector that infects along the injection track, Ad.DF3-E1 infection was detectable throughout the tumor xenografts. (
  • High-Incidence of Human Adenoviral Co-Infections in Taiwan. (
  • Recently, a significant increase of adenoviral infections was observed in Taiwan. (
  • Identifying changes in genes that involve the immune system should help scientists better understand how the immune system works to protect people from infection and may help develop new therapies. (
  • Viral infections in the normal host are usually self-limited as the innate and acquired immune systems mount successful antiviral responses. (
  • However the most extensively-studied MAV, MAV-1, causes fatal disease in C57BL/6 immune-competent mice, making it a poor proxy for the much milder effects of adenovirus infection observed in humans [ 8 ]. (
  • 2002) Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. (
  • Depending on the parasite subgenus [subgenus Leishmania (L.) vs. Viannia (V.) ], species and strain, the dose of transmitted parasites, the inoculation site and the quality of the immune response of the infected host, the infection can remain asymptomatic, or turn into a diverse set of clinical disease manifestations. (
  • Unlike previous reports on group C adenoviruses, trans-complementation of group B adenoviruses by co-infection with mouse adenovirus 1 did not rescue replication. (
  • Acute respiratory infections (ARI) are the major worldwide health problem associated with high morbidity and mortality rates. (
  • Viral and bacterial infections of the respiratory tract are important causes of morbidity in the first year of life. (
  • Local, state, and federal officials recommended 1) use of U.S. Environmental Protection Agency-approved viricide cleaners on common touch areas in communal gathering places, 2) frequent patient and staff member handwashing, 3) isolation of patients with fever ≥100°F (37.8°C) lasting ≥24 hours, and 4) a 72-hour deferral for new admissions during implementation of recommended infection control measures. (
  • Nosocomial infections are common in pediatric patients and can be fatal in infants and immunocompromised patients. (
  • Syrian hamsters are susceptible to infection with certain human adenoviruses, and the pathology accompanying these infections is similar to what is observed with adenovirus-infected human patients. (
  • Among all patients (n=643) adenovirus was detected on 13.2% by DFA and/or PCR 6/139 (4.3%) adults from ERP, 7/205 (3.4%) from HCW samples, 4/69 (5.8%) from RTO and 68/230 (29.5%) from HSCT patients . (
  • Surgical face masks were originally introduced to protect patients from wound infection and contamination from surgeons (the wearer) during surgical procedures, and were later adopted to protect healthcare workers against acquiring infection from their patients. (
  • Adenovirus isolation rates in acute flaccid paralysis patients. (
  • These results offer further perspectives for the therapeutic use of recombinant adenovirus in the complementation of specific molecular defects in DNA repair, with the prospect of devising tools for the prevention of skin tumors in XP patients. (
  • Naher and colleagues examined EBV polymerase chain reaction (PCR) tests in 92 men and women from a sexually transmitted infection (STI) clinic in patients for which STIs had been excluded. (
  • A case of upper respiratory tract infection (URTI) was defined as coryza and sore throat without LRTI in any student. (
  • Viral upper respiratory tract infection is often complicated by bacterial infections. (
  • Influenza is one of the common etiologies of the upper respiratory tract infection (URTI). (
  • Adenovirus diagnosis in blood requires the use of molecular methods. (
  • 1 , 2 Previous studies have investigated several potential viral causes of KD, including herpesviruses, 3 parvoviruses, 3 adenoviruses, 4 retroviruses, 5 and coronaviruses, 6 , 7 without finding support for a specific viral etiology. (
  • It is the most common infectious disease in humans and is mainly caused by coronaviruses or rhinoviruses. (
  • However, the setting of this outbreak of adenovirus ARD is similar to settings of previous military ARD outbreaks. (
  • On October 23rd, the New Jersey Department of Health confirmed an outbreak of adenovirus at the Wanaque Center for Nursing and Rehabilitation. (
  • Epidemiological analysis and follow-up of human rhinovirus infection in children with asthma exacerbation. (
  • We hypothesized that the susceptibility of human gliomas to Ad would likely be heterogeneous due to variable expression of these receptors. (
  • Anyone who has ever had a cold knows about acute respiratory infections (URIs). (
  • Early diagnosis of AdVs infections is critical for patient management and infection control measurements. (
  • Six specimens yielded adenovirus, identified as subgenus B by the polymerase chain reaction assay, and as adenovirus 11 by microneutralization assays (2-4). (
  • Xu W, McDonough MC, Erdman DD (2000) Species-specific identification of human adenoviruses by a multiplex PCR assay. (
  • Species-specific identification of human adenoviruses by a multiplex PCR assay. (
  • Two respiratory specimens were positive for adenovirus by PCR. (
  • In humans, adenoviruses cause acute mucous membrane infections of the upper respiratory tract, the eyes, and frequently the regional lymph nodes, bearing considerable resemblance to the common cold. (
  • Can adenoviruses cause acute respiratory disease? (
  • citation needed] Most infections are mild and require no therapy or only symptomatic treatment. (
  • Most adenovirus infections cause mild respiratory illness, such as the common cold. (
  • Most infections are mild. (