Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses.
Virus diseases caused by the ADENOVIRIDAE.
Species of the genus MASTADENOVIRUS, causing a wide range of diseases in humans. Infections are mostly asymptomatic, but can be associated with diseases of the respiratory, ocular, and gastrointestinal systems. Serotypes (named with Arabic numbers) have been grouped into species designated Human adenovirus A-F.
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
Proteins transcribed from the E1A genome region of ADENOVIRUSES which are involved in positive regulation of transcription of the early genes of host infection.
Proteins transcribed from the E1B region of ADENOVIRUSES which are involved in regulation of the levels of early and late viral gene expression.
Proteins transcribed from the E4 region of ADENOVIRUSES. The E4 19K protein transactivates transcription of the adenovirus E2F protein and complexes with it.
Proteins encoded by adenoviruses that are synthesized prior to, and in the absence of, viral DNA replication. The proteins are involved in both positive and negative regulation of expression in viral and cellular genes, and also affect the stability of viral mRNA. Some are also involved in oncogenic transformation.
An Ig superfamily transmembrane protein that localizes to junctional complexes that occur between ENDOTHELIAL CELLS and EPTHELIAL CELLS. The protein may play a role in cell-cell adhesion and is the primary site for the attachment of ADENOVIRUSES during infection.
Proteins transcribed from the E3 region of ADENOVIRUSES but not essential for viral replication. The E3 19K protein mediates adenovirus persistence by reducing the expression of class I major histocompatibility complex antigens on the surface of infected cells.
A genus of ADENOVIRIDAE that infects MAMMALS including humans and causes a wide range of diseases. The type species is Human adenovirus C (see ADENOVIRUSES, HUMAN).
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
A genus of ADENOVIRIDAE that infects birds. The type species is FOWL ADENOVIRUS A.
Deoxyribonucleic acid that makes up the genetic material of viruses.
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.
The very first viral gene products synthesized after cells are infected with adenovirus. The E1 region of the genome has been divided into two major transcriptional units, E1A and E1B, each expressing proteins of the same name (ADENOVIRUS E1A PROTEINS and ADENOVIRUS E1B PROTEINS).
Inflammation of the lung parenchyma that is caused by a viral infection.
Proteins that form the CAPSID of VIRUSES.
Established cell cultures that have the potential to propagate indefinitely.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Inflammation, often mild, of the conjunctiva caused by a variety of viral agents. Conjunctival involvement may be part of a systemic infection.
Species of the genus MASTADENOVIRUS that causes fever, edema, vomiting, and diarrhea in dogs and encephalitis in foxes. Epizootics have also been caused in bears, wolves, coyotes, and skunks. The official species name is Canine adenovirus and it contains two serotypes.
INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.
Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.
A vascular disease of the LIVER characterized by the occurrence of multiple blood-filled CYSTS or cavities. The cysts are lined with ENDOTHELIAL CELLS; the cavities lined with hepatic parenchymal cells (HEPATOCYTES). Peliosis hepatis has been associated with use of anabolic steroids (ANABOLIC AGENTS) and certain drugs.
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
Ribonucleic acid that makes up the genetic material of viruses.
Proteins transcribed from the E2 region of ADENOVIRUSES. Several of these are required for viral DNA replication.
A genus of the family PICORNAVIRIDAE whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated "human enterovirus".
The functional hereditary units of VIRUSES.
The outer protein protective shell of a virus, which protects the viral nucleic acid.
An alpha integrin with a molecular weight of 160-kDa that is found in a variety of cell types. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds. Integrin alphaV can combine with several different beta subunits to form heterodimers that generally bind to RGD sequence-containing extracellular matrix proteins.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
Carbon-containing phosphonic acid compounds. Included under this heading are compounds that have carbon bound to either OXYGEN atom or the PHOSPHOROUS atom of the (P=O)O2 structure.
Proteins found in any species of virus.
Visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses.
A pyrimidine base that is a fundamental unit of nucleic acids.
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Species of the genus MASTADENOVIRUS, causing neurological disease in pigs.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Compounds consisting of chains of AMINO ACIDS alternating with CARBOXYLIC ACIDS via ester and amide linkages. They are commonly cyclized.
A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
The type species of the genus AVIADENOVIRUS, family ADENOVIRIDAE, an oncogenic virus of birds. This is also called CELO virus for chick embryo lethal orphan virus.
Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Substances elaborated by viruses that have antigenic activity.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, which are dependent on a coinfection with helper adenoviruses or herpesviruses for their efficient replication. The type species is Adeno-associated virus 2.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
The top portion of the pharynx situated posterior to the nose and superior to the SOFT PALATE. The nasopharynx is the posterior extension of the nasal cavities and has a respiratory function.
Process of determining and distinguishing species of bacteria or viruses based on antigens they share.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
The process by which a DNA molecule is duplicated.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Use of attenuated VIRUSES as ANTINEOPLASTIC AGENTS to selectively kill CANCER cells.
Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Elements of limited time intervals, contributing to particular results or situations.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Simultaneous inflammation of the cornea and conjunctiva.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Disease having a short and relatively severe course.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Vaccines used to prevent infection by any virus from the family ADENOVIRIDAE.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
An abnormal elevation of body temperature, usually as a result of a pathologic process.
The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.
The rate dynamics in chemical or physical systems.
Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. Helper and satellite may be of the same or different genus.
Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-galactosides. Deficiency of beta-Galactosidase A1 may cause GANGLIOSIDOSIS, GM1.

Strain variation in adenovirus serotypes 4 and 7a causing acute respiratory disease. (1/452)

In order to determine the suitability of vaccine strains established in the 1960s for a new vaccine, a comprehensive study of strain variation of adenovirus serotype 4 (AV 4) and AV 7 was undertaken. A 1,500-bp region of the hexon gene containing the AV neutralization epitopes from prototype, vaccine, and community-acquired strains and from wild-type strains from military personnel that cause acute respiratory disease (ARD) was sequenced and analyzed. The whole hexon gene from prototype strains, vaccine strains, and selected isolates was sequenced. AV 7 and AV 7a were found to have distinct genotypes, and all vaccine and wild-type strains recovered from 1963 to 1997 had the AV 7a genotype. There was no significant strain variation in the neutralization epitopes of the AV 7a genotype over a 42-year period. The evolution of AV 4 was more complex, with continuous genetic drift punctuated by replacement with a new strain. The current strain of AV 4, which has been in circulation since 1995, is significantly different from the AV 4 prototype and the vaccine strains. Genetic differences were confirmed to be antigenic differences by neutralization tests, which define the new strain as an AV 4 variant. A type-specific PCR for AV 4, AV 7/7a, and AV 21 was developed, and this PCR facilitated the rapid identification of isolates from outbreaks of ARD.  (+info)

Serotyping of adenoviruses on conjunctival scrapings by PCR and sequence analysis. (2/452)

To detect and identify adenovirus (Ad), we investigated hypervariable regions (HVRs) of Ad by using a combination of PCR and direct sequencing (PCR-sequence) method. Primers for nested PCR to amplify the conserved region in the hexon protein containing HVRs were designed based on hexon gene sequences derived from GenBank. These two primer sets amplified a DNA fragment of 7 HVRs from 16 prototypes of Ad, which were divided into five subgenera, including seven serotypes that are the predominant causative agents of acute conjunctivitis in Japan, and from 31 recent conjunctival scraping specimens from patients with adenoviral conjunctivitis. HVR DNA sequences were determined by means of universal sequence primers. Analysis of the predicted amino acid homology of HVRs among Ad prototypes suggested three regions, HVR4, -5, and -7, to be candidates for the neutralization epitopes. The clinical serotype of specimens was determined by the PCR-sequence method with reference to these three HVRs. The serotype determined according to this method was identical to that obtained by culture isolation and the neutralization test (NT) in all scraping samples, whereas the results of this method did not match PCR and restriction fragment length polymorphism (PCR-RFLP) analysis in five samples. It took only three days to detect Ad and to identify the serotype, in contrast to culture isolation-NT, which took at least 2 weeks. These findings indicate that our newly developed PCR-sequence method is applicable for the detection and serotyping of human Ads.  (+info)

Molecular and serological characterization of adenovirus genome type 7h isolated in Japan. (3/452)

In 1996, three adenovirus type 7 (Ad7) strains were isolated from children with fever and upper respiratory diseases in Japan. Restriction endonucleases (REs) analysis and PCR amplification of the E3 7.7 kDa ORF revealed that these strains were genotype Ad7h and closely related to an Argentine Ad7h strain, which has been reported to be highly virulent and so far predominant only in South America. These strains showed weak cross-neutralizing activity and specific haemagglutination-inhibition activity to Ad3 antiserum. The present findings suggest that Ad7h in South America has spread to other parts of the world. Since the seroprevalence to Ad7 in the current Japanese population is very low due to the absence of Ad7 circulation in Japan for decades, Ad7 outbreak as a typical case of re-emerging infectious diseases is a cause for serious concern.  (+info)

Adenoviruses from human immunodeficiency virus-infected individuals, including two strains that represent new candidate serotypes Ad50 and Ad51 of species B1 and D, respectively. (4/452)

Adenovirus (Ad) isolates from a large number of human immunodeficiency virus (HIV)-infected individuals were compared serologically and genetically with Ad isolates from immunocompetent patients. Between 1982 and 1994, stool and urine samples from 137 subjects with AIDS hospitalized in The Netherlands yielded 143 Ad strains. Forty additional Ad strains were obtained from 35 HIV-positive patients in Manchester, United Kingdom, in 1992 and 1993. Of these 183 HIV-associated Ad strains, 84% belonged to species D and 3% belonged to species C. These strains were compared with 2,301 Ad strains collected during general diagnostic examinations in The Netherlands from 1973 to 1992. Of the latter strains, 5% belonged to species D and 49% belonged to species C. Two of the Ads isolated from fecal specimens of AIDS patients represent new serotypes: candidate Ad serotype 50 (prototype strain, Wan) of subspecies B1 and candidate Ad serotype 51 (prototype strain, Bom) of species D. The DNA restriction enzyme patterns of strains Wan and Bom differed from the patterns of all established prototypes.  (+info)

Adenovirus infections in hematopoietic stem cell transplant recipients. (5/452)

We report a 12% incidence of adenovirus infections among 532 recipients of hematopoietic stem cell transplant (HSCT) from January 1986 through March 1997. The median time from day of stem cell infusion to first positive culture was 41 days. Recipients of allogeneic stem cells, as opposed to autologous stem cell recipients, were more likely to have a culture positive for adenovirus (16% vs. 3%; P<.0001). Pediatric patients were also more likely than adults to have a positive culture (23% vs. 9%; P<.0001). Among stem cell recipients with partially matched related donors, pediatric recipients appear to be at significantly greater risk for infection than adult recipients (P<.001). Positive cultures were associated with evidence of invasion in 64% of cases (41 of 64). A multiple logistic regression analysis showed that isolating adenovirus from more than 1 site correlated with greater risk for invasive infections (P=.002). Invasive infections were associated with poorer chance of survival.  (+info)

Large, persistent epidemic of adenovirus type 4-associated acute respiratory disease in U.S. army trainees. (6/452)

In May 1997, a large, persistent epidemic of adenovirus type 4-associated acute respiratory disease began at Fort Jackson, South Carolina, the largest army basic training center. The epidemic lasted until December and declined when vaccine administration resumed. More than 1,000 male and female trainees were hospitalized; 66.1% of those hospitalized had an adenovirus type 4 isolate.  (+info)

Efficacy of topical cidofovir on multiple adenoviral serotypes in the New Zealand rabbit ocular model. (7/452)

PURPOSE: The goal of the present study was to determine the efficacy of topical 0.5% cidofovir twice daily for 7 days on the replication of multiple adenovirus (Ad) serotypes of subgroup C (Ad1, Ad5, Ad6) in the New Zealand rabbit ocular model. METHODS: In duplicate experiments for each serotype, a total of 20 rabbits (Ad5) or 16 rabbits each (Ad1 and Ad6) were inoculated topically in both eyes, with 1.5 X 10(6) pfu/eye of the appropriate virus. Twenty-four hours later, the rabbits in each serotype group were randomly divided into two topical treatment groups: I, 0.5% cidofovir; II, control vehicle. Treatment was twice daily for 7 days. All eyes were cultured for virus on days 0, 1, 3, 4, 5, 7, 9, 11, and 14. RESULTS: Compared to the control, treatment with 0.5% cidofovir reduced the following: mean Ad titer (days 1 to 7) for Ad1 (6.3 +/- 20 x 10(1) versus 2.5 +/- 3.9 X 102 pfu/ml; P < 0.0003), Ad5 (3.4 +/-5.8 x 102 versus 1.6 +/- 2.0 x 10(3) pfu/ml; P < 0.000001), and Ad6 (1.2 +/- 5.1 x 10(2) versus 5.5 +/-14 x 10(2) pfu/ml; P = 0.015); reduced Ad-positive eyes/total for Adl [45/128 (35%) versus 84/128 (66%); P = 0.000002], Ad5 [84/160 (53%) versus 131/152 (86%); P < 0.000001], and Ad6 [36/128 (28%) versus 82/128 (64%); P < 0.000001]: and reduced the duration of Ad shedding forAdl (4.9 +/-1.9 versus 9.3 +/- 3.3 days; P < 0.00007), Ad5 (6.4 +/- 2.8 versus 11.5 +/- 2.3 days; P < 0.0001), and Ad6 (4.4 +/- 2.1 versus 8.4 +/- 2.5 days; P < 0.00004). CONCLUSIONS: Topical 0.5% cidofovir twice daily for 7 days demonstrated significant antiviral activity against multiple adenoviral serotypes (Ad1, Ad5, and Ad6) in the New Zealand rabbit ocular model. These in vivo data expand in vitro studies indicating the efficacy of cidofovir against different adenovirus serotypes and support its use in clinical trials.  (+info)

Molecular epidemiology of ocular isolates of adenovirus 8 obtained over nine years. (8/452)

Twenty nine strains of adenovirus 8 have been isolated over nine years in Strasbourg, France, 22 of which were from one private ophthalmologist. To assess a possible relation between these strains, the DNA of adenovirus was analysed by restriction fragment length polymorphism using eight different enzymes. Among these, three proved discriminant (Xba I, Bgl II, Eco RI) and made it possible to define 13 genotypes differing from each other by one to three DNA bands. Seven genotypes were unique isolates, while three, representing 16 strains, were isolated over five to eight years. All the genotypes but one were closely related, with 87% homology. All 13 differed from an adenovirus 8 strain from Lyon (homology 68-76%). This study confirmed the stability of adenovirus 8 in a given population.  (+info)

Adenoviruses are the most common cause of acute viral infections of the conjunctiva, occurring epidemically or sporadically throughout all seasons. Clinically, 4 syndromes of adenoviral ocular infection have been recognized, as follows: epidemic keratoconjunctivitis, pharyngoconjunctival fever (PCF), nonspecific sporadic follicular conjunctiv...
86 PCR positive samples were inoculated onto Hep-2 cell for virus isolation, and 23 HAdV strains were isolated through 7-21 days post-inoculation, with isolation rate of 26.74%, which was close to that of 21.43% in the previous study (Thounaojam et al. 2016). The hexon gene sequence has widely been used for the classification of adenovirus types. In this study, the hexon gene of the 23 HAdV isolates was amplified and sequenced using primer designed by Sarantis et al. (Sarantis et al. 2004) (Forward primer: 5′-CTGATGTACTACAACAGCACTGGCAACATGGG-3′, Reverse primer: 5′-GCGTTGCGGTGGTGGTTAAATGGGTTTACGTTGTCCAT-3′, the amplicon length is 580-605 bp), and the nucleotide sequences were submitted to GenBank (accession numbers MN389388-MN389410). Molecular typing assignments were based on the identity of the closest matching sequences after both BLAST and phylogenetic analysis. Results showed that 9 of the 23 HAdV isolates (8 HAdV-3 and 1 HAdV-7) belonged to species B and 12 of the 23 (5 HAdV-1 and 7 ...
Doctors Ask: Adenovirus infection is exposed to all segments of the population. Basic manifestations of adenovirus infection The latent (incubation period) is usually 5-7 days. The disease most often begins acutely, from the phenomena of intoxication: slight increase in temperature, rashes in the body, chills, lethargy, headache, loss of appetite, etc.
Adenovirus infection generally may lead to common cold, pneumonia and pharyngitis.There are few types of adenoviruses. Specifically, adenoviruses types 8,19 and 37 will lead to keratoconjunctivitis mostly in adult.
In one mode of adenovirus infection (called lytic infection because it destroys large numbers of cells), adenoviruses kill healthy cells and replicate up to 1 million new viruses per cell killed, of which 1 to 5 percent are infectious. People with this kind of infection feel sick. In chronic or latent infection, a much smaller number of viruses are released, and healthy cells can multiply more rapidly than they are destroyed. People who have this kind of infection do not exhibit symptoms. Children who have normal immune systems usually experience only minor symptoms when infected with adenovirus. The course of infection tends to be more serious in children who are immunocompromised, such as those undergoing chemotherapy or those who have a disease that disrupts normal immune response (e.g. human immunodeficiency syndrome [HIV]). In such children, the virus more often affects organs such as the lungs, liver, and kidneys, and the risk of fatality increases. Symptoms common to respiratory illnesses ...
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Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States in association with outbreaks of acute respiratory disease with high rates of illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009-July 31, 2010, and describe 9 cases of HAdV-14p1 infection with characteristic mutations in the fiber and E1A genes that are phylogenetically indistinguishable from the viruses previously detected in the United States. Three patients died; 2 were immunocompromised, and 1 was an immunocompetent adult. We propose that surveillance should be increased for HAdV-14p1 and recommend that this virus be considered in the differential diagnosis of sudden-onset acute respiratory disease, particularly fatal infections, for which an etiology is not clear.
TY - JOUR. T1 - Survey of infectious agents involved in acute respiratory disease in finishing pigs. AU - Loeffen, W.L.A.. AU - Kamp, E.M.. AU - Stockhofe-Zurwieden, N.. AU - van Nieuwstadt, A.P.K.M.I.. AU - Bongers, J.H.. AU - Hunneman, W.A.. AU - Elbers, A.R.W.. AU - Baars, J.. AU - Nell, T.. AU - van Zijderveld, F.G.. PY - 1999. Y1 - 1999. U2 - 10.1136/vr.145.5.123. DO - 10.1136/vr.145.5.123. M3 - Article. VL - 145. SP - 123. EP - 129. JO - Veterinary Record. JF - Veterinary Record. SN - 0042-4900. IS - 5. ER - ...
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Get this from a library! Acute respiratory diseases: symposium organized by the College of Pathologists and delivered in London in February 1968;. [D A J Tyrrell; College of Pathologists.;]
The inner-city infants had lower rates of viral detection overall. This may suggest that other factors, such as bacteria or allergic reactions to air pollutions or toxic exposures, contribute significantly to respiratory illness. Sick urban infants had lower rates of two kinds of viruses, HRV and RSV, and higher rates of adenovirus infections, compared to suburban infants. In the urban babies, 4.8 percent of nasal washes tested positive for only adenovirus, while just 0.7 percent of samples from suburban babies were positive for only adenovirus. Adenovirus infections, either as a single pathogen or when detected in concert with other viruses, were significantly more common in the urban population, and this held true for each of the four urban locations where our study was conducted, the authors wrote ...
My son has this virus. He has pink eye in both eyes, the sore throat, ear infection, he had a fever for 3 days, diarrhea and he has said when he watches Tv its like the tv is spinning. He gets sick so fast that he has had just about every virus out there. So far this particular virus is lasting all most a week now. I cant wait till its completely gone. He has already been out of school for 4 days.... ...
Ann Treacy, Michael J. Carr, Linda Dunford, Gustavo Palacios, Gemma A. Cannon, Anthony OGrady, Julie Moran, Jaythoon Hassan, Aisling Loy, Jeff Connell, Deirdre Devaney, Peter Kelehan, William W. Hall ...
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Signs and Symptoms The two frequently encountered forms of viral conjunctivitis are pharyngoconjunctival fever (PCF) and epidemic keratoconjunctivitis (EKC).1-11 Pharyngoconjunctival fever is characterized by a fever, sore throat, history of recent upper respiratory infection (URI) and follicular conjunctivitis.1,2,4,7,9-11 The condition may be unilateral or bilateral, but classically presents in one eye and is spread to…. Read More ...
TY - JOUR. T1 - Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients. AU - Muller, William J.. AU - Levin, Myron J.. AU - Shin, Young Kyoo. AU - Robinson, Christine. AU - Quinones, Ralph. AU - Malcolm, Janet. AU - Hild, Elaine. AU - Gao, Dexiang. AU - Giller, Roger. PY - 2005/12/15. Y1 - 2005/12/15. N2 - Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT patients, 18 of whom had severe manifestations of infection. Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 patients. In vitro susceptibility to cidofovir was demonstrated in 12 clinical adenovirus isolates. Cidofovir is a promising treatment option for this population.. AB - Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT ...
Background Human Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. They particularly cause frequent morbidity among children. In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited st...
Albinana-Gimenez N., M.P. Miagostovich, B. Calgua, J.M. Huguet, L. Matia and R. Girones. 2009. Analysis of adenoviruses and polyomaviruses quantified by qPCR as indicators of water quality in source and drinking-water treatment plants. Water Res. 43:2011-2019. [PubMed]. Barrella K.M., P. Garrafa, T.A. Monezi, C.M. Harsi, C. Salvi, P.A. Violante and D.U. Mehnert. 2009. Longitudinal study on occurrence of adenoviruses and hepatitis A virus in raw domestic sewage in the city of Limeira, Sao Paulo. Braz. J. Microbiol. 40:102-107. [PubMed]. Bibby K. and J. Peccia. 2013. Prevalence of respiratory adenovirus species B and C in sewage sludge. Environ. Sci. Process Impacts. 15(2):336-8 [PubMed]. Cantalupo P.G, B. Calgua, G. Zhao, A. Hundesa, A.D. Wier, J.P. Katz, M. Grabe, R.W. Hendrix, R. Girones, D. Wang and others. 2011. Raw sewage harbors diverse viral populations. MBio. 2(5):e00180-11 [PubMed]. Cruz J.R., P. Caceres, F. Cano, J. Flores, A. Bartlett and B. Torun. 1990. Adenovirus types 40 and 41 and ...
TY - JOUR. T1 - Safety and Efficacy of CMX001 as Salvage Therapy for Severe Adenovirus Infections in Immunocompromised Patients. AU - Florescu, Diana F.. AU - Pergam, Steven A.. AU - Neely, Michael N.. AU - Qiu, Fang. AU - Johnston, Christine. AU - Way, SingSing. AU - Sande, Jane. AU - Lewinsohn, Deborah. AU - Guzman-Cottrill, Judith. AU - Graham, Michael L.. AU - Papanicolaou, Genovefa. AU - Kurtzberg, Joanne. AU - Rigdon, Joseph. AU - Painter, Wendy. AU - Mommeja-Marin, Herve. AU - Lanier, Randall. AU - Anderson, Maggie. AU - van der Horst, Charles. PY - 2012/5. Y1 - 2012/5. N2 - No therapeutic agent has yet been established as the definitive therapy for adenovirus infections. We describe the clinical experience of 13 immunocompromised patients who received CMX001 (hexadecyloxypropyl cidofovir), an orally bioavailable lipid conjugate of cidofovir, for adenovirus disease. We retrospectively analyzed 13 patients with adenovirus disease and viremia treated with CMX001; data were available for ...
Background. Military recruits are at a higher risk of respiratory infection than their civilian counterparts. Continuous outbreaks of adenovirus (Ad)â€associated acute respiratory disease were documented among US trainees before the implementation of serotype 4 (Ad4) and serotype 7 vaccines in 1971. The discontinuation of Ad vaccination programs in 1999 precipitated the reemergence of Ad in training sites, with Ad4 accounting for 98% of all diagnosed cases. Methods. A total of 724 Ad4 strains isolated from recruits presenting with febrile respiratory illness at 8 training sites nationwide between 1997 and 2003 were genome typed by restriction enzyme analysis. Results. Seven genome types were identified, all of which were distinct from the prototype Ad4p and the vaccine type 4p1. Results showed very different, and often stable, genome type distributions at different geographic sites, despite the homogeneity of the recruit source population. Conclusions. The data support the hypothesis that ...
Learn about the programs and services for Adenovirus Infections at Boston Childrens, ranked best Childrens Hospital by US News.
Vectors derived from human adenovirus type 5, which typically lack the E1A and E1B genes, induce robust innate immune responses that limit their therapeutic efficacy. mutant-infected cells in the absence or presence of exogenous IFN. Both the concentration of viral genomes detected during the late phase and the numbers of viral replication centers formed were strongly reduced in IFN-treated cells in the absence of the E1B protein, despite production of similar quantities of viral replication proteins. These defects could not be attributed to degradation of entering viral genomes, induction of apoptosis, or failure to reorganize components of PML nuclear bodies. Nor was assembly of Nutlin 3a the E1B- and E4 Orf6 protein- E3 ubiquitin ligase required to prevent inhibition of viral replication by IFN. However, by using RT-PCR, the E1B 55 kDa protein was demonstrated to be a potent repressor of expression of IFN-inducible genes in IFN-treated cells. We propose that a primary function of the ...
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Enteric viruses transmitted via the faecal-oral route occur in high concentrations in wastewater and may contaminate drinking water sources and cause disease. In order to quantify enteric adenovirus...
Adenoviral nucleic acid was detected by polymerase chain reaction (PCR) in pharyngeal and rectal swab samples of a cat seropositive for adenovirus and suffering from transient hepatic failure. The samples were taken at a one-year interval, and both faecal samples as well as the second pharyngeal sample were positive in ... read more PCR performed with general adenovirus primers. The size of the amplified products corresponded to that of the positive control. The identity of the amplicons was also confirmed by DNA sequencing. The 301 bp long hexon gene fragment was very similar to but distinguishable from the corresponding hexon sequence of human adenovirus type 2. This result suggests the possibility of persistent carrier status and shedding of adenovirus in cats. show less ...
Human adenovirus (HAdV) is a common pathogen causing a broad spectrum of diseases. HAdV encodes the pVII protein, which is involved in nuclear delivery, protection and expression of viral DNA. To suppress the cellular interferon (IFN) and RNA interference (RNAi) systems, HAdVs encode non-coding virus-associated (VA) RNAs. In this thesis we have investigated the functional significance of the pVII protein and VA RNAI in HAdV-5 infected cells.. We report that the propeptide module is the destabilizing element targeting the precursor pVII protein for proteasomal degradation. We also found that the Cul3-based E3 ubiquitin ligase complex alter the precursor pVII protein stability via binding to the propeptide sequence. In addition, we show that inhibition of the Cul3 protein reduces HAdV-5 E1A gene expression. Collectively, our results suggest a novel function for the pVII propeptide module and involvement of Cul3 in viral E1A gene expression.. Our studies show that the cellular E3 ubiquitin ligase ...
Human adenovirus 2 ATCC ® VR-846D™ Designation: DNA from Human adenovirus 2 strain Adenoid 6 [ATCC ® VR-846™] Application: It is suitable for use in polymerase chain reaction (PCR) for viral gene products and other molecular virology applications. Respiratory research
Human adenovirus 4 ATCC ® VR-1572D™ Designation: DNA from Human adenovirus 4 strain RI-67 [ATCC ® VR-1572™] Application: It is suitable for use in polymerase chain reaction (PCR) for viral gene products and other molecular virology applications. Respiratory research
Adenoviruses (HAdV) can cause serious life threatening infections, especially in pediatric patients after allogeneic stem cell transplantation (SCT). To improve the morbidity and mortality rate of HAdV infected patients after SCT three issues have been explored: which patients are at risk for HAdV infection, what is the best treatment for ... read more HAdV infected patients and when do we start treatment. We found that in pediatric patients HAdV-DNA positivity in nasopharyngeal aspirate before SCT is a very important risk factor for developing invasive HAdV infection after SCT. As determined with multiplex immuno-assay we also found that children with a localized HAdV infection have a different cytokine profile compared with patients with an invasive HAdV infection after SCT. Cytokine signatures can also be helpful to differentiate invasive HAdV infection from other SCT related complications as Graft versus Host Disease (GvHD) and Epstein-barr virus infection. Immune profiling could possibly ...
We identified previously unrecognized variations in the fiber gene and E4 ORF 6/7 peptides among the various genome types of Ad7. In particular, multiple amino acid changes at E4 ORF 6/7 peptides showed genome type-specific differences between Ad7d and a novel genome type Ad7l. However, no genetic divergence was identified in the hexon gene or in E3 peptides among the 12 Korean strains of Ad7. This result indicates that the nucleotide structures of the fiber gene and of E4 ORF 6/7 peptides might have contributed to the genetic heterogeneity during the Ad7 epidemics in Korea, whereas those of the hexon gene and E3 were highly conserved.. So far, the fiber gene and E4 have rarely been addressed with regard to the evolution and molecular epidemiology of Ad7 strains (17). Restriction analysis of genomic DNA has been the most popular method of describing the molecular epidemiology of the adenoviruses (18). However, little is known about sequence variations with regard to the genome type within an ...
Adenovirus has been associated with both sporadic and epidemic disease and, with regard to infections among military recruits, who were routinely immunized against types 4 and 7 from 1971 until the cessation of vaccine production in 1996. Adenovirus became a significant cause of economic cost and morbidity in this setting. A live oral vaccine against adenovirus types 4 and 7 was approved for use in this population by the US Food and Drug Administration (FDA) in 2011, and subsequent incidence of acute respiratory disease declined.. Of interest is the role of adenoviruses as vectors in vaccination and in gene therapy. [1, 2, 3] Adenoviruses can infect various cells, both proliferating and quiescent, and thus hold the promise of targeting many different tissues and diseased cell lines.. The genome of adenovirus is well known and can be modified with relative ease to induce lysis or cytotoxicity of a specified cell line without affecting others.. The virus itself can be engineered to remove its ...
DNA restriction analysis was carried out on a sample of 212 epidemiologically unrelated adenovirus (Ad) strains of serotype 7 isolated in Chile, Uruguay, and Argentina from nasopharyngeal aspirates of children with acute lower respiratory disease between 1984 and 1990. The identified genome types were Ad7b (n = 12), Ad7c (n = 21), and Ad7h (n = 179). The analysis of the occurrence of the three genome types throughout the study period revealed that Ad7c was the predominant virulent variant in 1984 and indicated that a shift to genome type 7h took place in 1986. Ad7b cocirculated with the other genomic variants at a relatively low frequence. ...
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NEW YORK (GenomeWeb News) - Researchers from China and the US will sequence 100 human adenoviruses, including ones that cause respiratory, gastrointestinal, and ocular diseases, under a partnership announced today.
Feucht, Judith; Opherk, Kathrin; Lang, Peter; Kayser, Simone; Hartl, Lena; Bethge, Wolfgang; Matthes-Martin, Susanne; Bader, Peter; Albert, Michael H.; Maecker-Kolhoff, Britta; Greil, Johann; Einsele, Hermann; Schlegel, Paul-Gerhardt; Schuster, Friedhelm R.; Kremens, Bernhard; Rossig, Claudia; Gruhn, Bernd; Handgretinger, Rupert; Feuchtinger, Tobias ...
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There are many stages in the development of a new drug for viral infection and such processes are even further complicated for adenovirus by the fact that there are at least 51 serotypes, forming six distinct groups (A-F), with different degree of infectivity. This review attempts to address the importance of developing pharmaceuticals for adenovirus and also review recent development in drug discovery for adenovirus, including newer strategies such as microRNA approaches. Different drug screening strategies will also be discussed.
Adenovirus Type 9, 0.1 mg. The many different serotypes of human adenoviruses (Ad) are divided into six subgroups, of which all Ad subgroup A and B and two subgroup D Ads can elicit tumors in infected rodents.
This post is about adenovirus infection, a major cause of illness both minor and severe in the United States, especially among children in group settings.
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-Maintains strong financial position with $314.5 million in capital at quarter end-. DURHAM, N.C., May 09, 2016-- Chimerix, a biopharmaceutical company developing novel antivirals to address unmet medical needs, today reported top-line results from an interim analysis of the AdVise trial of brincidofovir for serious adenovirus infection and other corporate...
Define epidemic keratoconjunctivitis. epidemic keratoconjunctivitis synonyms, epidemic keratoconjunctivitis pronunciation, epidemic keratoconjunctivitis translation, English dictionary definition of epidemic keratoconjunctivitis. n. Inflammation of the cornea and conjunctiva. Noun 1. keratoconjunctivitis - inflammation of the cornea and conjunctiva inflammation, redness, rubor - a...
TY - JOUR. T1 - Adenovirus infections in heart transplantation. AU - Florescu, Diana F.. AU - Kwon, Joong Y.. AU - Dumitru, Ioana. PY - 2013/7. Y1 - 2013/7. N2 - Adenovirus infections have been associated with significant morbidity and mortality in immunocompromised hosts. The clinical significance of adenovirus disease in heart transplantation is not well-defined; in particular, the significance of adenovirus identification in myocardium remains unclear. Although severe adenovirus disease has been described in heart transplant recipients, adenovirus infections seem to be more frequently associated with increased risk of adverse cardiac events, such as rejection, ventricular dysfunction, coronary vasculopathy, need for retransplantation, and graft loss because of death. Cidofovir is currently considered the standard of treatment for adenovirus disease not responding to reduction of immunosuppression.. AB - Adenovirus infections have been associated with significant morbidity and mortality in ...
We determined the complete genome sequence of epidemic keratoconjunctivitis (EKC)-related human adenoviruses (HAdVs). We analysed a total of 12 HAdV strains; three prototype strains and two HAdV-8, three HAdV-19 and three HAdV-37 clinical isolates from EKC patients in Japan, and one novel serotype of HAdV. Genome organization of these serotypes was identical to those of the recently determined HAdV-19 and HAdV-37. The identities of the whole genome were over 99 % among strains from the same serotype, except for HAdV-19p, which is not associated with conjunctivitis, resulting in the formation of a distinct cluster in the phylogenetic analysis. The penton, loop 1 and loop 2 of hexon, early region 3 (E3) and fiber were hypervariable regions between serotypes. Results suggest that the HAdV-19 clinical strain is a recombinant of HAdV-19p-like and HAdV-37-like strains, and that the acquisition of the penton, E3 or fiber may be related to ocular tropism.
Gene probes developed locally for both enteric Adenoviruses 40 and 41 were used to determine whether these viruses were present in both raw and treated waters. Approximately sixty water samples were concentrated by ultra filtration and analysed directly for the presence of enteric adenoviruses. Three pre-treatment techniques, namely sephadex columns, cellulose fibre and Geneclean(TM) were tested for the removal of inhibitory substances from concentrated water samples. The effect of chlorine treatment on viral detection using gene probe hybridization was also examined by exposing adenoviruses to chlorine concentrations of up to 20mg/l for 1 hour. Enteric adenoviruses were detected in up to 59% of both raw and treated waters analysed, Cellulose fibre and Geneclean(TM) were found to successfully remove inhibitory substances from concentrated raw waters. Viral I NA was detected after exposure to a range of chlorine concentrations indicating that the viruses detected in the treated waters may have ...
Adenovirus type 37 (Ad37) is a leading cause of epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular disease. Whereas most other adenoviruses infect cells by engaging CD46 or the coxsackie and adenovirus receptor (CAR), Ad37 binds previously unknown sialic acid-containing cell surface molecules. By glycan array screening, we show here that the receptor-recognizing knob domain of the Ad37 fiber protein specifically binds a branched hexasaccharide that is present in the GD1a ganglioside and that features two terminal sialic acids. Soluble GD1a glycan and GD1a-binding antibodies efficiently prevented Ad37 virions from binding and infecting corneal cells. Unexpectedly, the receptor is constituted by one or more glycoproteins containing the GD1a glycan motif rather than the ganglioside itself, as shown by binding, infection and flow cytometry experiments. Molecular modeling, nuclear magnetic resonance and X-ray crystallography reveal that the two terminal sialic acids dock into two of
In 2005, a human adenovirus strain (formerly known as HAdV-D22/H8 but renamed here HAdV-D53) was isolated from an outbreak of epidemic keratoconjunctititis (EKC), a disease that is usually caused by HAdV-D8, -D19, or -D37, not HAdV-D22. To date, a complete change of tropism compared to the prototype has never been observed, although apparent recombinant strains of other viruses from species Human adenovirus D (HAdV-D) have been described. The complete genome of HAdV-D53 was sequenced to elucidate recombination events that lead to the emergence of a viable and highly virulent virus with a modified tropism. Bioinformatic and phylogenetic analyses of this genome demonstrate that this adenovirus is a recombinant of HAdV-D8 (including the fiber gene encoding the primary cellular receptor binding site), HAdV-D22, (the ε determinant of the hexon gene), HAdV-D37 (including the penton base gene encoding the secondary cellular receptor binding site), and at least one unknown or unsequenced HAdV-D strain.
In 2005, a human adenovirus strain (formerly known as HAdV-D22/H8 but renamed here HAdV-D53) was isolated from an outbreak of epidemic keratoconjunctititis (EKC), a disease that is usually caused by HAdV-D8, -D19, or -D37, not HAdV-D22. To date, a complete change of tropism compared to the prototype has never been observed, although apparent recombinant strains of other viruses from species Human adenovirus D (HAdV-D) have been described. The complete genome of HAdV-D53 was sequenced to elucidate recombination events that lead to the emergence of a viable and highly virulent virus with a modified tropism. Bioinformatic and phylogenetic analyses of this genome demonstrate that this adenovirus is a recombinant of HAdV-D8 (including the fiber gene encoding the primary cellular receptor binding site), HAdV-D22, (the ε determinant of the hexon gene), HAdV-D37 (including the penton base gene encoding the secondary cellular receptor binding site), and at least one unknown or unsequenced HAdV-D strain.
Human adenovirus, of the Adenoviridae family, is a nonenveloped icosahedral particle containing a single linear dsDNA genome. Human adenovirus comprises 6 species (A through F) consisting of serotypes 1 - 51, and associated with a variety of clinical illnesses. Serotypes 1-39, 42-51 are associated with a variety of respiratory disease, generally in children and immunocompromised persons; whereas serotypes 40 and 41 is associated with enteric disease (enteric adenovirus) particularly in children - these enteric adenoviruses will not be detected with the assay described here. Serotypes 12, 18, 31 have a high oncogenic potential and serotypes 4 and 7 are associated with acute respiratory disease (ARD) frequently in military recruits and typically occur in the winter and spring. Smaller outbreaks of serotypes 3, 4, and 7 occur in the summertime and are associated with contaminated swimming pool water.. Adenovirus infections of the eye may lead to pharyngo-conjunctival fever, follicular ...
I had Epidemic Keratoconjunctivitis 2.5years ago and still have scarring on my cornea, intense glare sensitivity and am still wearing glasses for every day use (I never wore them before the infection)....
Human adenoviruses (HAdVs) cause a wide range of diseases worldwide, including respiratory infections. Studies on HAdV molecular epidemiology are limited in Cameroon. The purpose of this study is to document the different types HAdV circulating in Cameroon in children with acute respiratory infections. Nasopharyngeal swabs were collected from 811 children under 15 years from 2011 to 2014. The HAdV detection was assessed by semi-quantitative generic PCR r-gene®. The HAdV-positive samples were typed by amplification and sequencing of partial hexon gene and a real-time PCR. Demographic data were collected and analyzed. The infection and hospitalization risk factors were assessed thought the Chi-square test. A total of 137/220 HAdV-positive samples were amplified successfully. Six species of HAdV (Mastadenovirus A to F) were detected with B (108/220) and C (47/220) being the predominant strains. Hospitalization and age were significantly associated to HAdV-B and HAdV-C respectively. Phylogenetic analysis
Seventy-eight cases were identified in patients from four eye care practices, two family practices, and the hospital emergency department. The median patient age was 45 years (range = 9 months-90 years), and 33 (42%) were men. Ocular signs and symptoms included redness (68%), watery discharge (50%), and pain (29%). Severe signs included corneal infiltrates (17%) and pseudomembranes (6%). At least 12 cases (15%) were health care-associated (Figure). One health care-associated case occurred in a health care worker. Seventeen patients whose infections were not health care-associated reported a symptomatic household or community contact. Among 45 conjunctival swabs available for testing, 19 (42%) were positive for HAdV-8. Genome sequences obtained from five HAdV-8 isolates were 100% identical with one another and showed 97.7% (accession number AB861610.1) to 99.9% (accession number KT340070.1) nucleotide sequence similarity to other HAdV-8 genome sequences available in GenBank, the National ...
To define the bottlenecks that restrict antigen expression after oral administration of viral-vectored vaccines, we tracked vectors derived from the human adenovirus type 5 at whole body, tissue and cellular scales throughout the digestive tract in a murine model of oral delivery. After intragastric administration of vectors encoding firefly luciferase or a model antigen, detectable levels of transgene-encoded protein or mRNA were confined to the intestine, and restricted to delimited anatomical zones. Expression of luciferase in the form of multiple small bioluminescent foci in the distal ileum, cecum and proximal colon suggested multiple crossing points. Many foci were unassociated with visible Peyers patches, implying that transduced cells lay in proximity to villous rather than follicle-associated epithelium, as supported by detection of transgene-encoded antigen in villous epithelial cells. Transgene-encoded mRNA but not protein was readily detected in Peyers patches, suggesting that post
It has been known for some time that the human adenovirus serotype 5 (Ad5) E4orf6 and Sox18 E1B55K proteins work in concert to degrade p53 and to regulate selective export of late viral mRNAs during productive infection. H1299 human lung carcinoma cells after expression of E1B55K and E4orf6 using adenovirus vectors. Several species were detected and identified by mass spectroscopy and for one of these integrin α3 we went on in a parallel study to confirm it as a substrate of the complex (F. Dallaire et al. J. Virol. 83:5329-5338 2009 Although the system has some limitations it may still be of some general use in identifying candidate substrates of any viral cullin-based E3 ubiquitin ligase complex and we suggest a series of criteria for substrate validation. During the past decade protein degradation has become increasingly recognized SVT-40776 (Tarafenacin) as a critical mechanism by which cells regulate a number of fundamental processes (reviewed in references 37 57 and 59). Degradation ...
The interaction between clinicians and patients produces a dynamic that can affect both and forms a part of the risk associated with medical practice. The clinician can sometimes become the main agent for the spread of disease by omissions, which usually do not affect the medical personnel or the patients. However, under certain circumstances, members of the medical workforce can become risks for their own health and that of their patients by becoming a vector for disease transmission. In this study, we report on an outbreak of conjunctivitis involving both clinicians and patients. Human adenovirus (Ad) belongs to a family comprising about 100 members that are grouped into six subgenera (A-F) based on several biochemical and molecular criteria. Fifty-one Ad types have been identified as human pathogens, some of which are able to survive under adverse conditions outside of the human body [1,2]. A typical Ad infection includes a 5-12 day incubation period before the onset of symptoms followed by a ...
Recombinant adenoviruses currently are used for a variety of purposes, including gene transfer in vitro, vaccination in vivo, and gene therapy (1-4). Several features of adenovirus biology have made such viruses the vectors of choice for certain of these applications. For example, adenoviruses transfer genes to a broad spectrum of cell types, and gene transfer is not dependent on active cell division. Additionally, high titers of viruses and high levels of transgene expression generally can be obtained.. Decades of study of adenovirus biology have resulted in a detailed picture of the viral life cycle and the functions of the majority of viral proteins (5, 6). The genome of the most commonly used human adenovirus (serotype 5) consists of a linear, 36-kb, double-stranded DNA molecule. Both strands are transcribed and nearly all transcripts are heavily spliced. Viral transcription units are conventionally referred to as early (E1, E2, E3, and E4) and late, depending on their temporal expression ...
Adenoviruses (HAdVs) are nonenveloped lytic DNA viruses with 67 different human serotypes. HAdV infection post transplant seems to be caused by endogenous viral reactivation in most cases....
Mouse anti Adenovirus Hexon antibody, clone 7C11 reacts with human, canine, bovine, monkey and rat adenoviruses. It is very likely that it
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Adenovirus and pregnancy - What is adenovirus infection? Many forms. This virus can produce several forms of infection. Pharyngo-conjunctival fever (or swimming pool fever) is one of the better known, but also gastroenteritis, upper respiratory tract infections and pneumonia can all occur.
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Human adenoviruses (HAdVs) often cause mild respiratory infections. These infections, however, can potentially become fatal in immunosuppressive patients. Unfortunately, there has been no specific anti-HAdV drug approved for treatment of HAdV infections. In this study, a time-course transcriptome of HAdV-infected human lung epithelial cells (A549 cells) was performed and compared with perturbation datasets of 890 drug-treated A549 cells from the library of integrated network-based cellular signatures (LINCS) database to predict previously unknown therapeutic drug-HAdV relationships using a characteristic direction (CD) algorithm. We performed experiments to validate a prediction for the anti-diabetic drug rosiglitazone as a candidate drug for treatment of anti-HAdV both in vivo and in vitro. The Type I interferon (IFNs) signaling pathway was negatively regulated during the course of HAdV infection and rosiglitazone increased STAT1 phosphorylation for antiviral IFN response induction. Taken ...
Fingerprint Dive into the research topics of Accumulation of early and intermediate mRNA species during subgroup C adenovirus productive infections. Together they form a unique fingerprint. ...
13:2; potential epub Adenovirus notions; tenure bhakti 1? On the epub Adenovirus Methods and of this interest, are above under form. 1282 An epub Adenovirus Methods and Protocols: Adenoviruses, Ad study read by Porten - Szubin 1987:187.
Scientists are reporting discovery of a potential new drug for epidemic keratoconjunctivitis (EKC) -- sometimes called pink eye -- a highly infectious eye disease that may occur in 15 million to 20 million people annually ...
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Fingerprint Dive into the research topics of Two early mRNA species in adenovirus type 2 transformed rat cells. Together they form a unique fingerprint. ...
1NLN: Crystallographic structure at 1.6-A resolution of the human adenovirus proteinase in a covalent complex with its 11-amino-acid peptide cofactor: insights on a new fold
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Medical Virology 8 Luis M De La Maza Ellena M Peterson No Preview Available 2014 Medical Virology 8 Luis M De La Maza Ellena M Peterson No Preview Available 2013 View All Common Terms And Phrases Acad Sci Usa Activity Adenovirus Antigen Antipeptide Antibodies Antiviral Assay Binding Blood Cell Lines Cell Surface Cellular Chronic Class I Antigens Clinical Coxsackievirus Culture
Detect adenovirus rescue even before cytopathic effect (CPE) is observed. Ensure high titer by harvesting amplified adenovirus at the optimal time
... implication for adenovirus-mediated gene therapy". Human Gene Therapy. 10 (6): 957-64. doi:10.1089/10430349950018355. PMID ... June 1999). "Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands". Infection and Immunity ... "Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin". The Journal of ... Hiratsuka T, Nakazato M, Ashitani J, Matsukura S (February 1999). "[A study of human beta-defensin-1 and human beta-defensin-2 ...
... also participates in ATR protein kinase signalling pathways during adenovirus infection. Two transcript variants ... 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi: ... 2005). "Protein arginine methylation during lytic adenovirus infection". Biochem. J. 383 (Pt 2): 259-65. doi:10.1042/BJ20040210 ... Heterogeneous nuclear ribonucleoprotein U-like protein 1 is a protein that in humans is encoded by the HNRNPUL1 gene. This gene ...
Shieh, Wun-Ju (10 September 2021). "Human adenovirus infections in pediatric population - An update on clinico-pathologic ... It may appear similar to herpes simplex type I, acanthamoeba, and fungal infection. Adequate infection control measures should ... a type of adenovirus disease caused by adenoviruses. It typically presents as a conjunctivitis with a sudden onset of a painful ... A type of adenoviral keratoconjunctivitis in very young children can present with a high fever, sore throat, ear infection, ...
"Serologic Evidence for Human Infection with Adenovirus-Associated Viruses". JNCI: Journal of the National Cancer Institute. ... He was a pioneer in research on adenoviruses and their role in human diseases. The discoveries of adenoviruses by Rowe et al. ( ... Huebner, R. J.; Rowe, W. P.; Lane, W. T. (1962). "Oncogenic Effects in Hamsters of Human Adenovirus Types 12 and 18". ... Hoggan, M. D.; Blacklow, N. R.; Rowe, W. P. (1966). "Studies of small DNA viruses found in various adenovirus preparations: ...
The viruses thought to be involved include the adenovirus, which causes respiratory infections; the human parvovirus B19, an ... infection that affects children; and the human parainfluenza virus. Some patients attribute the onset of PMR to stress.[ ... CRP is produced by the liver in response to an injury or infection, and people with polymyalgia rheumatica usually have high ... citation needed] Persons having the HLA-DR4 type of human leucocyte antigen appear to have a higher risk of PMR. No specific ...
As of 2014[update], brincidofovir is in Phase III clinical trials for use in humans against cytomegalovirus and adenovirus. ... which was then picked up by national news sources about a boy with an adenovirus infection following a bone marrow transplant. ... adenovirus, poxvirus, and ebolavirus infections. It has been used off-label for the treatment of monkeypox. ... Brincidofovir is not yet FDA approved for adenovirus or cytomegalovirus due to lack of efficacy in clinical trials. In a trial ...
As of May 2022, laboratory testing showed infection with human adenovirus in about three quarters of cases. This serotype has ... 2022-07-13). "A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection". New England Journal of Medicine. ... The leading hypothesis is a link to human adenovirus infection, particularly serotype F41. ... It remained unclear, however, whether human adenovirus 41 was the cause. One possibility is that restrictions imposed during ...
Viral causes include human respiratory syncytial virus (RSV), human metapneumovirus, adenovirus, human parainfluenza viruses, ... The symptoms of CAP are the result of lung infection by microorganisms and the response of the immune system to the infection. ... Viral infections weaken the immune system, making the body more susceptible to bacterial infection, including bacterial ... The most common viral causes are influenza, parainfluenza, human respiratory syncytial virus, human metapneumovirus and ...
"Oncolytic adenovirus modified with somatostatin motifs for selective infection of neuroendocrine tumor cells". Gene Therapy. 18 ... Human alpha-1-antitrypsin is another protein that has been produced from goats and is used in treating humans with this ... "Pig Heart Transplants For Humans Could Be on Their Way". IFLScience. Reardon S (November 2015). "New life for pig-to-human ... Sato K, Sasaki E (February 2018). "Genetic engineering in nonhuman primates for human disease modeling". Journal of Human ...
Infection by human adenovirus accounts for 65% to 90% of cases of viral conjunctivitis. Adenoviruses are the most common cause ... Bacterial infections, allergies, other irritants, and dryness are also common causes. Both bacterial and viral infections are ... of cases of viral conjunctivitis are caused by adenoviruses. Viral conjunctivitis is often associated with an infection of the ... "Molecular epidemiology of circulating human adenovirus types in acute conjunctivitis cases in Chandigarh, North India". Indian ...
... and adenovirus 11. AHC can only exist in a human host and is transmitted through human contact with an infected individual or ... There are 57 variants of this virus, that each cause 5-10% of upper respiratory infections in humans. These viruses are some of ... Adenoviruses are a medium-sized variant that are nonenveloped, like Enterovirus 70. They have a double-stranded linear DNA ... Within one to two days of infection, symptoms will begin to become apparent. Enterovirus 70 is a member of the genus of viruses ...
"Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer ... Falk W, Leonard EJ (May 1982). "Chemotaxis of purified human monocytes in vitro: lack of accessory cell requirement". Infection ... "The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection". PLOS ONE. 7 (8): ... In humans, 19 family members are currently known, with most S100 genes (S100A1 to S100A16). Proteins in the S100 gene family ...
"Oncolytic adenovirus modified with somatostatin motifs for selective infection of neuroendocrine tumor cells". Gene Therapy. 18 ... The researchers forecast that one day this technique could be used to restore the heartbeat in humans who would otherwise need ... The most common virus used for gene delivery come from adenoviruses as they can carry up to 7.5 kb of foreign DNA and infect a ... Genetically-modified virus explodes cancer cells GM virus shrinks cancer tumours in humans Leja J, Yu D, Nilsson B, Gedda L, ...
They cause respiratory, intestinal, and eye infections in humans (especially the common cold). When these viruses infect a host ... It was found that in the absence of the E1B-55Kd viral protein, adenovirus caused very rapid apoptosis of infected, p53(+) ... Antibodies to HSV-1 are common in humans, however complications due to herpes infection are somewhat rare. Caution for rare ... There are two main types of virus infection: lytic and lysogenic. Shortly after inserting its DNA, viruses of the lytic cycle ...
Adenoviruses account for about 10% of acute respiratory infections in children.[citation needed] These viruses are a frequent ... The antifungal efficacy of copper was compared to aluminium on the following organisms that can cause human infections: ... Within six hours, 99.999% of the adenovirus particles were inactivated. Within six hours, 50% of the infectious adenovirus ... Adenovirus is a group of viruses that infect the tissue lining membranes of the respiratory and urinary tracts, eyes, and ...
Data show that HUVEC cells overexpressing T-cadherin after adenovirus infection enter S-phase more rapidly and exhibit ... CDH13 human gene details in the UCSC Genome Browser. (Articles with short description, Short description is different from ... T-cadherin at the US National Library of Medicine Medical Subject Headings (MeSH) CDH13 human gene location in the UCSC Genome ... Re-expression of T-cadherin in human breast cancer cells (MDAMB435) in culture, which originally do not express T-cadherin, ...
... treatment with Ezh1/2 inhibitors reduced infection of multiple viral pathogens, including human cytomegalovirus, adenovirus, ... the site of infection, and whether the infection is primary (initial infection) or recurrent (recurring symptoms). Popular, ... Upon initial infection, herpes simplex virus (HSV) causes acute lytic infection of epithelial cells, usually at either genital ... HSV infection can cause corneal scarring and blindness from herpes keratitis, central nervous system infections, and even death ...
... orf6 and orf6/7 genes for those from human adenovirus HAdV-C5. Serotype Y25 belongs to the species Human mastadenovirus E of ... In 2017, the ChAdOx1 vector was used in a trial for a vaccine candidate against human malaria infection. The researchers ... 13 July 2012). "A novel chimpanzee adenovirus vector with low human seroprevalence: improved systems for vector derivation and ... However, the widespread seroprevalence of neutralizing antibodies to common human adenovirus serotypes limits their use. Simian ...
The bacterial infection occurs mainly after a viral infection. Some examples are canine distemper virus, adenovirus type 1 and ... The symptoms of viral infections like canine distemper virus, adenovirus type 1 and 2, parainfluenza virus and feline ... Also an obvious sign of a regular virus infection is that the pet does not respond to the threat of a regular viral infection. ... If the neutrophils are increased, there is a bacterial infection, but if the eosinophils are increased the infection is ...
Recombinant Adenovirus-Based Vaccine Provides Long-Term Protection for Non-Human Primates from Lethal Ebola Infection". ... It contains a human adenovirus serotype 5 vector (Ad5) with the glycoprotein gene from ZEBOV. Their findings were consistent ... The Ad26.ZEBOV is derived from human adenovirus serotype 26 (Ad26) expressing the Ebola virus Mayinga variant glycoprotein, ... Vaccines include replication-deficient adenovirus vectors, replication-competent vesicular stomatitis (VSV) and human ...
Non-LPD that have significant percentages of cases associated with EBV infection (see Epstein-Barr virus infection) include the ... Human herpes virus 8 (HHV8) is associated with four rare lymphoproliferative disorders: 1) a subset of diffuse large B cell ... adenovirus, or toxoplasma. HIV, rubella, and Hepatitis viruses A, B, and C can produce an illness resembling IM. The acute EBV ... Worldwide, EBV infection is associated with 1% to 1.5% of all cancers. The vast majority of these EBV-associated cancers are ...
Human Neutrophil Defensin-1, -3, and -4 Are Elevated in Nasal Aspirates from Children with Naturally Occurring Adenovirus ... 4 Are Elevated in Nasal Aspirates from Children with Naturally Occurring Adenovirus Infection," Canadian Respiratory Journal, ... Initially human alpha defensin peptides were isolated from the neutrophils and are thus called human neutrophil peptides. Human ... Human neutrophil peptides are found in human atherosclerotic arteries, inhibit LDL metabolism and fibrinolysis and promote Lp(a ...
In addition, DPPC has been shown to be related to infection of polarized cells by a specific kind of human adenovirus (HAdV-C2 ... However, adsorption is not optimal at human body temperature for DPPC alone, because at 37 °C it is found in a gel phase. The ... This phospholipid is found in a solid/gel phase at 37 °C (at the effective temperature of the human body). Its melting point is ... It also plays an important role in the study of liposomes and human bilayers. Lung surfactant (LS) is a surface-active material ...
The vaccine contained three separate replication-defective vectors based on Human Adenovirus C serotype 5 (HAdV-5). Each of the ... In fact, certain groups of the vaccine recipients were seen to have a higher risk of HIV infection as compared to the placebo ... Study was a Phase IIb clinical trial intended to study the efficacy of an experimental HIV vaccine based on a human adenovirus ... It was hoped that the adenovirus vectors would carry these HIV-1 genes into the cell, and that this would result in the ...
They also emerged as a vehicle for human gene therapy Also in the early 1960s, Green and others showed that human adenoviruses ... and determining the molecular and kinetic parameters of adenovirus infection. He showed that adenoviruses could be divided into ... In 1962, scientists at the National Institutes of Health discovered that certain serotypes of human adenoviruses can induce ... His major focus of investigation was human adenoviruses. He and his colleagues performed foundational viral research; growing ...
BHK-21 cells are susceptible to human adenovirus D, reovirus 3, and vesicular stomatitis virus (Indiana strain). BHK-21 cells ... BHK cells are also used to study viral infections. High-glucose DMEM FBS fetal bovine serum 5% (when you freeze, add 10%) GLU ...
Additionally, m6A has been reported to impact viral infections. Many RNA viruses including SV40, adenovirus, herpes virus, Rous ... Mapping of m6A in human and mouse RNA has identified over 18,000 m6A sites in the transcripts of more than 7,000 human genes ... "Dynamics of Human and Viral RNA Methylation during Zika Virus Infection". Cell Host & Microbe. 20 (5): 666-673. doi:10.1016/j. ... m6A is also found on the RNA components of R-loops in human cells, where it is involved in regulation of stability of RNA:DNA ...
v t e (Genes on human chromosome 14, Human proteins, All stub articles, Human chromosome 14 gene stubs). ... "Infection and Immunity Immunophenotyping (3i) Consortium". Pelka P, Scimè A, Mandalfino C, Joch M, Abdulla P, Whyte P (Jul 2007 ... "Adenovirus E1A proteins direct subcellular redistribution of Nek9, a NimA-related kinase". Journal of Cellular Physiology. 212 ... Serine/threonine-protein kinase Nek9 is an enzyme that in humans is encoded by the NEK9 gene. NEK9 has been shown to interact ...
The adenovirus cannot replicate, so does not cause further infection, and instead acts as a vector to transfer the SARS-CoV-2 ... In early April the team were awarded £22 million of funding from the Government of the United Kingdom to run human trials. The ... In 2012 Green moved to the University of Oxford, where she joined the Wellcome Centre for Human Genetics. Here Green expanded ... "Catherine Green - Wellcome Centre for Human Genetics". Retrieved 24 April 2020. "Hear from the Oxford COVID- ...
Humans infected with adenoviruses display a wide range of responses, from no symptoms at all to the severe infections typical ... Most infections with adenovirus result in infections of the upper respiratory tract. Adenovirus infections often present as ... Siadenovirus Testadenovirus In humans, currently there are 88 human adenoviruses (HAdVs) in seven species (Human adenovirus A ... and avoiding close contact with people with symptomatic adenovirus infection. Those with symptomatic adenovirus infection are ...
Adenovirus Adenovirus infection. RNA virus. Rotavirus. Norovirus. Astrovirus. Coronavirus. Hepatitis. DNA virus. HBV (B). RNA ... Human polyomavirus 2 Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV ... "Latent tuberculosis infection (LTBI)". World Health Organization (ഭാഷ: ഇംഗ്ലീഷ്). ശേഖരിച്ചത് 2018-11-12.. ... "Asymptomatic HIV infection: MedlinePlus Medical Encyclopedia". 2016-02-02. ശേഖരിച്ചത് 2016-02-14.. ...
Infection party *Pox. *Flu. *CoV. *Thiomersal. *Vaccines and SIDS. *Cedillo v. Secretary of Health and Human Services ...
Cepivo Sputnik V je sestavljeno iz dveh adenovirusnih vektorjev; pri prvem odmerku se uporabi adenovirus 26 (Ad26), ki je enak ... "S. Korea's Genexine begins human trial of coronavirus vaccine". Reuters. 19. 6. 2020. Arhivirano iz prvotnega spletišča dne 11 ... "Safety and Immunogenicity Study of Inactivated Vaccine for Prevention of SARS-CoV-2 Infection (COVID-19) (Renqiu)". ... "Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among ...
Monto AS (1984). "Coronaviruses". In Evans AS (ed.). Viral infections of humans. Viral infections of humans: epidemiology and ... adenoviruses, and other known common cold viruses. Eventually, this was solved.[25] The new cultivating method was introduced ... In humans and birds, they cause respiratory tract infections. Mild illnesses in humans include some cases of the common cold ( ... Myint SH (1995). "Human Coronavirus Infections". In Siddell SG (ed.). The Coronaviridae. The Viruses. Springer US. pp. 389-401 ... Missing or empty ,title=. (help) ... WHO disease staging system for HIV infection and disease *Children. *Teens / Adults ...
Rhinovirus - Coronavirus - Human parainfluenza viruses - Human respiratory syncytial virus - Adenovirus - Enterovirus - ... "Novel coronavirus infection: time to stay ahead of the curve". Eastern Mediterranean Health Journal. 19 Suppl 1: S3-4. PMID ... Human polyomavirus 2 Progressive multifocal leukoencephalopathy. RNA virus. MeV Subacute sclerosing panencephalitis. LCV ... in Light of Past Human Coronavirus Outbreaks (pdf) ,format=. requires ,url=. (help). MDPI, Basel, Switzerland. പുറങ്ങൾ. 1-3.. ...
Adenovirus Adenovirus infection. RNA virus. Rotavirus. Norovirus. Astrovirus. Coronavirus. Hepatitis. DNA virus. HBV (B). RNA ... However, a number of studies show that this 'asymptomatic infection' may also lead to development of other human pathologies ... Trematode infection). Blood fluke. *Schistosoma mansoni / S. japonicum / S. mekongi / S. haematobium / S. intercalatum * ... Tapeworm - Tapeworm infection Cestoda, Taenia multiceps intestine stool rare worldwide Diphyllobothriasis - tapeworm ...
Chang Y, Brewer NT, Rinas AC, Schmitt K, Smith JS (জুলাই ২০০৯)। "Evaluating the impact of human papillomavirus vaccines"। ... vaccine schedule for postexposure prophylaxis to prevent human rabies: recommendations of the advisory committee on ... "Primary vaccine failure to routine vaccines: Why and what to do?"। Human Vaccines & Immunotherapeutics। 12 (1): 239-43। ডিওআই: ...
Human coronavirus 229E, Human coronavirus NL63, Human coronavirus OC43, Human coronavirus HKU1, Middle East respiratory ... I: dsDNA viruses (e.g. Adenoviruses, Herpesviruses, Poxviruses). *II: ssDNA viruses (+ strand or "sense") DNA (e.g. ... Satellites depend on co-infection of a host cell with a helper virus for productive multiplication. Their nucleic acids have ... Human parvovirus B19, canine parvovirus Naked Icosahedral ss II 4. Herpesviridae Herpes simplex virus, varicella-zoster virus, ...
Human coronavirus 229E, Human coronavirus NL63, Human coronavirus OC43, Human coronavirus HKU1, Middle East respiratory ... I: dsDNA viruses (e.g. Adenoviruses, Herpesviruses, Poxviruses). *II: ssDNA viruses (+ strand or "sense") DNA (e.g. ... Satellites depend on co-infection of a host cell with a helper virus for productive multiplication. Their nucleic acids have ... Human parvovirus B19, canine parvovirus Naked Icosahedral ss II 4. Herpesviridae Herpes simplex virus, varicella-zoster virus, ...
Due to overlap with other infections such as adenovirus, imaging without confirmation by rRT-PCR is of limited specificity in ... Outside the human body, the virus is destroyed by household soap, which bursts its protective bubble. SARS-CoV-2 is closely ... 19 in individuals with a high clinical suspicion of infection. Detection of a past infection is possible with serological tests ... However, infection can occur over longer distances, particularly indoors. Infectivity can begin four to five days before the ...
In contrast to medical wisdom in the 1960s and 1970s, Huebner was confident that viruses were a cause of cancer in humans and ... From that culture they isolated cytomegalovirus, as well as the first of a large family of adenoviruses. Dr. Robert M. Chanock ... This led to the discovery of the role that cytomegalovirus plays in opportunistic infections in patients with immunodeficiency ...
This method can be used on plants that are not susceptible to Agrobacterium infection and also allows transformation of plant ... Mali S (January 2013). "Delivery systems for gene therapy". Indian Journal of Human Genetics. 19 (1): 3-8. doi:10.4103/0971- ... Viruses used for gene therapy to date include retrovirus, adenovirus, adeno-associated virus and herpes simplex virus. However ... lentiviral and human foamy virus are RNA-based viral vectors that reverse transcript and integrated into the host genome, ...
Chang CJ, Chao JC (April 2002). "Effect of human milk and epidermal growth factor on growth of human intestinal Caco-2 cells". ... Wang N, Verna L, Hardy S, Forsayeth J, Zhu Y, Stemerman MB (September 1999). "Adenovirus-mediated overexpression of c-Jun and c ... Infection and Immunity. 76 (4): 1410-22. doi:10.1128/IAI.01141-07. PMC 2292885. PMID 18227166. Kida Y, Inoue H, Shimizu T, ... Kim S, Yu SS, Lee IS, Ohno S, Yim J, Kim S, Kang HS (April 1999). "Human cytomegalovirus IE1 protein activates AP-1 through a ...
Numerous human pathogenic viruses in circulation are encased in lipid bilayers, and they infect their target cells by causing ... As a result, flaviviruses and pseudo typed retroviruses have a harder time infecting TAM-deficient DCs, albeit infection can be ... DNA viruses Adenoviruses Parvoviruses Polyomaviruses Anelloviruses RNA viruses Caliciviruses Picornaviruses Reoviruses ... One of the main parts of human pathogenic viruses is glycoprotein. They have been shown to play significant roles in immunity ...
"Prevalence of the initiator over the TATA box in human and yeast genes and identification of DNA motifs enriched in human TATA- ... For example, one study used the adenovirus TATA promoter sequence (5'-CGCTATAAAAGGGC-3') as a model binding sequence and found ... "Expression and nuclear localization of the TATA-box-binding protein during baculovirus infection". The Journal of General ... Similarly, in humans only 24% of genes have promoter regions containing the TATA box. Genes containing the TATA-box tend to be ...
No signs and symptoms of lobar consolidation, meaning that the infection is restricted to small areas, rather than involving a ... adenovirus, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), COVID-19 and measles. Chest ... "Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin". bioRxiv ... "Diagnosis of atypical pathogens in patients hospitalized with community-acquired respiratory infection". Scand. J. Infect. Dis ...
... is an adenovirus protein of 14kDa which regulates growth in all stages of the adenovirus (Ad) infection. E4orf4 partners mainly ... In humans, the Noxa homologue is known as APR/PMAIP1. Upon receiving intrinsic death signals, the gene NOXA encodes for the ... Toolan, H.W., Saunders, E.L., Southam, C.M., Moore, A.E. and Levin, A.G. (1965) H-l virus viremia in the human. Proc. Sot. Exp ... Conserved domains among human, mouse, and rat homologs include the leucine zipper (LZ) domain at the C-terminal region, two ...
Acute bronchiolitis is usually the result of infection by respiratory syncytial virus (72% of cases) or human rhinovirus (26% ... Other agents that cause this illness include human metapneumovirus, influenza, parainfluenza, coronavirus, adenovirus, ... Treatment of bronchiolitis is usually focused on the hydration and symptoms instead of the infection itself since the infection ... Respiratory infections were shown to be significantly less common among breastfed infants and fully breastfed RSV-positive ...
24 infections) 106 12198 = 0.86 % {\displaystyle {106 \over 12198}=0.86\%} for the placebo group (106 infections) The relative ... Principles of Epidemiology in Public Health Practice (3rd ed.), U.S. Department of Health and Human Services and Centers for ... Implications of the Adenovirus Vector Experience". Science. 344 (6179): 49-51. doi:10.1126/science.1250672. ISSN 0036-8075. PMC ... While conventional efficacy/effectiveness data typically shows the ability to prevent a symptomatic infection, this expanded ...
PEGylation of adenoviruses for gene therapy can help prevent adverse reactions due to pre-existing adenovirus immunity. A ... PEGylated interferon alfa-2a or alfa-2b are commonly used injectable treatments for hepatitis C infection. PEG is soluble in ... Bowman L (4 December 2004). "Study on dogs yields hope in human paralysis treatment". Seattle Post-Intelligencer. Blume G, Cevc ... Seregin SS, Amalfitano A (2009). "Overcoming pre-existing adenovirus immunity by genetic engineering of adenovirus-based ...
A human Anellovirus called TTV is included within this classification and is found in almost all humans, infecting them ... It then injects its DNA or RNA into the host to initiate infection. In animal cells these viruses get into the cell through the ... Some of these viruses require host cell polymerases to replicate their genome, while others, such as adenoviruses or herpes ... Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must ...
Directed evolution was applied on human adenovirus, one of many viruses that are being developed as oncolytic agents, to create ... The infection of cells with viruses containing the genes for angiostatin and endostatin synthesis inhibited tumour growth in ... An oncolytic adenovirus, a genetically modified adenovirus named H101, was approved in China in 2005 for the treatment of head ... in human non-small cell lung cancer". Human Gene Therapy. 10 (18): 3013-29. doi:10.1089/10430349950016410. PMID 10609661. S2CID ...
The host amoeba also showed a partial recovery from the infection by the Samba virus. Virophages have small double-stranded DNA ... Some of the largest genomes of virophages are similar to the genome size of an adenovirus. All virophages known so far have ... genomes from diverse habitats including the human gut, plant rhizosphere, and terrestrial subsurface, from 27 distinct ... Virophages are small, double-stranded DNA viral phages that require the co-infection of another virus. The co-infecting viruses ...
Carrigan, Phd (1997). "Adenovirus Infections in Immunocompromised Patients". The American Journal of Medicine. 102 (3): 71-74. ... 2008). "Acute meningoencephalitis due to human immunodeficiency virus type 1 infection in 13 patients: clinical description and ... If caused by an infection then the infection can be treated with antibiotic drugs.[citation needed] Meningitis Meningism ... which is an infection or inflammation of the meninges, and encephalitis, which is an infection or inflammation of the brain. ...
It is the most common ocular disease of cattle (mostly beef). IBK is similar to human pink eye and causes severe infection of ... or adenovirus, bacteria such as Mycoplasma boviculi or Listeria monocytogenes, or infestation by Thelazia, a nematode. Vitamin ... Infectious bovine keratoconjunctivitis (IBK), also known as pinkeye, New Forest eye or blight, is a veterinary infection of ... Asymptomatic carrier animals can also be source of infection. Ultraviolet (UV) radiation is implicated in cattle with no ...
Human leptin is a 16-kDa protein of 167 amino acids. A human mutant leptin was first described in 1997, and subsequently six ... It was found in a two-year-old boy with extreme obesity with recurrent ear and pulmonary infections. Treatment with metreleptin ... March 2010). "Adenovirus-mediated leptin expression normalises hypertension associated with diet-induced obesity". Journal of ... In humans it has been observed that the ratio of leptin in the CSF compared to the blood is lower in obese people than in ...
Cui X, Wen L, Wu Z, Liu N, Yang C, Liu W, Human adenovirus type 7 infection associated with severe and fatal acute lower ... Severe Infections with Human Adenovirus 7d in 2 Adults in Family, Illinois, USA, 2014 On This Page ... Severe Infections with Human Adenovirus 7d in 2 Adults in Family, Illinois, USA, 2014. Emerging Infectious Diseases. 2016;22(4 ... Severe Infections with Human Adenovirus 7d in 2 Adults in Family, Illinois, USA, 2014. Emerg Infect Dis. 2016;22(4):730-733. ...
This report describes children with severe hepatitis and adenovirus admitted to a childrens hospital in Alabama. ... This report describes children with severe hepatitis and adenovirus admitted to a childrens hospital in Alabama. ... were used to test for adenovirus, coronavirus 229E, coronavirus HKU1, coronavirus NL63, coronavirus OC43, human metapneumovirus ... Acute Hepatitis and Adenovirus Infection Among Children - Alabama, October 2021-February 2022. Weekly / May 6, 2022 / 71(18); ...
Adenoviruses, Human Adenovirus Infections, Human Adult Aged Dispatch DNA, Viral/genetics Genome, Viral Humans Male Molecular ... Human Adenovirus Type 55 Distribution, Regional Persistence, and Genetic Variability Cite CITE. Title : Human Adenovirus Type ... Title : Severe Infections with Human Adenovirus 7d in 2 Adults in Family, Illinois, USA, 2014 Personal Author(s) : Kajon, ... Severe Infections with Human Adenovirus 7d in 2 Adults in Family, Illinois, USA, 2014. ...
Human Adenovirus Associated with Severe Respiratory Infection, Oregon, USA, 2013-2014 Magdalena Kendall Scott. , Christina ... Human Adenovirus Associated with Severe Respiratory Infection, Oregon, USA, 2013-2014. ... Total HAdV also includes HAdV-E4 (1 case), which was in a nonhospitalized child (10-18 y). HAdV, human adenovirus; ICU, ... Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the ...
The second group is at special risk for infections with adenovirus, polyomavirus BK, recurrent hepatitis C, human ... However, CMV infection can result from allograft infection, blood products, or natural infection posttransplantation among CMV- ... human metapneumovirus), bacterial infections (eg, Streptococcus pneumoniae, Haemophilus influenzae), urinary tract infections, ... Chronic norovirus and adenovirus infection in a solid organ transplant recipient. Pediatr Infect Dis J. 2008 Apr. 27(4):360-2. ...
Human rhinovirus * Adenovirus * Respiratory syncytial virus Bacterial infections in the differential diagnosis include the ... Viral infections (which may occur simultaneously with COVID-19) in the differential diagnosis include the following [3, 4] :. * ... In addition, a pulse oximeter can be used to catch a COVID-19 infection, as many patients have been found on initial assessment ... If an infected patient must leave home, he or she should wear a facemask in order to protect others from infection. ...
... was evaluated for the rapid diagnosis of ocular adenovirus infections. In 36 culture-proven cases of adenovirus ocular ... infection, direct Adenoclone testing of conjunctival swabs was positive in 24 of 31 patients … ... Adenoviridae Infections / diagnosis* * Adenovirus Infections, Human / diagnosis* * Evaluation Studies as Topic * Eye Diseases ... was evaluated for the rapid diagnosis of ocular adenovirus infections. In 36 culture-proven cases of adenovirus ocular ...
Human adenovirus associated with severe respiratory infection, Oregon, USA, 2013-2014External. Scott MK, Chommanard C, Lu X, ... The epidemiology of human immunodeficiency virus infection and care among adult and adolescent females in the United States, ... Extended human-to-human transmission during a monkeypox outbreak in the Democratic Republic of the CongoExternal. Nolen LD, ... Sexually transmitted infections associated with alcohol use and HIV infection among men who have sex with men in Kampala, ...
Categories: Adenovirus Infections, Human Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
HONOURs Genomic analyses of human adenoviruses unravel novel recombinant genotypes associated with severe infections in ... Genomic analyses of human adenoviruses unravel novel recombinant genotypes associated with severe infections in pediatric ... Genomic analyses of human adenoviruses unravel novel recombinant genotypes associated with severe infections in pediatric ... Epidemiology of Human Adenoviruses: A 20-Year Retrospective Observational Study in Hospitalized Patients in Bern, Switzerland ...
Human adenoviruses (HAdVs) cause ocular infections. The most severe disease among ocular infections is epidemic ... Genome variability of human adenovirus type 8 causing epidemic keratoconjunctivitis during 1986-2003 in Japan. Xue-Hai Jin,1 ... Human adenovirus type 8 (HAdV-8) is one of the major serotypes isolated from patients with EKC. DNA restriction enzyme analyses ... Ishiko H, Shimada Y, Konno T, Hayashi A, Ohguchi T, Tagawa Y, Aoki K, Ohno S, Yamazaki S. Novel human adenovirus causing ...
There are more than 50 types of immunologically distinct adenoviruses that can cause infections in humans. Adenoviruses most ... There is no specific treatment for adenovirus infections.. Adenovirus type 41 commonly causes pediatric acute gastroenteritis, ... While there have been case reports of hepatitis in immunocompromised children with adenovirus type 41 infection, adenovirus ... Case-finding efforts at this hospital identified four additional pediatric patients with hepatitis and adenovirus infection for ...
... that causes throat and eye infections may play a part in obesity. ... Human immunodeficiency virus and hepatitis C virus detection ... According to researchers in the U.S. a common virus (adenovirus-36), that causes throat and eye infections may play a part in ... Half of the tissue of each patient was then exposed to adenovirus-36, a cause of respiratory tract infections, diarrhoea and ... Genomic analysis of mpox virus genomes reveal multiple lineages with human-to-human transmissibility ...
Treatment with ARA-A begun as late as 7 days after virus infection was significantly effective in preventing death; no ... on the course of fatal disseminated vaccinia virus infection in immunosuppressed mice. ... Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5 F. L. Graham, J. Smiley, W. C. Russell and ... Montgomerie J. Z., Becroft D. M. O., Croxson M. C., Doak P. B., North J. D. K. 1969; HerpeS-simpleX-virus infection after renal ...
In fact, adenovirus 5 has been isolated in one patient with a concurrent viral infection. [14] APMPPE also has been associated ... Birdshot retinochoroidopathy, which often has an association with the presence of the human leukocyte antigen A29 (HLA-A29), ... Acute posterior multifocal placoid pigment epitheliopathy associated with an adenovirus type 5 infection. Am J Ophthalmol. 1975 ... with human leukocyte antigen DR2 (HLA-DR2) and human leukocyte antigen B7 (HLA-B7), suggesting a genetic predisposition to the ...
... other forms of human detritis, medical wastes, human wastes, and routine solid waste.1057-1061Cockroaches, in particular, have ... Common respiratory viruses in pediatric-care areas include rhinoviruses, respiratory syncytial virus (RSV), adenoviruses, ... of infections resulting from S. aureus were identified as MRSA infections, and 25.2% of enterococcal infections were attributed ... Environmental infection-control strategies must based on the principles of the "chain of infection," regardless of the disease ...
human embryonic kidney. MOI. multiplicity of infection. Ad-βgal. adenovirus vector expressing β-galactosidase.. ... human constitutive androstane receptor. Ad-hCAR. adenovirus vector expressing hCAR. CSE. cigarette smoke extract. PBS. ... This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. ... In contrast, the expression of CYP2B6 was not enhanced by adenovirus vector expressing β-galactosidase, a control vector, ...
... hMPV and Adenovirus) to 12% (hMPV and Human Bocavirus). hMPV and RSV was 4%. In another study in China found co-infection rate ... human metapneumovirus and human bocavirus (a Parvoviridae virus causing respiratory infections identified in 2005). Co- ... Disease: Human Metapneumovirus , Pneumonia Symptom/Presentation: Cough , Fever and Fever of Unknown Origin , Infections ,. ... Zhao X, Chen X, Zhang Z. Outbreak of Human Metapneumovirus Infection in Children in Chongqing, China. Pediatrics. 2008;s135. ...
In particular, respiratory infections are problematic; in early 2003, World Health Organization issued a worldwide alert for a ... early detection at the human-animal interface will provide earlier warning. Here, we review recent emerging virus treats for ... A Mini Review of the Zoonotic Threat Potential of Influenza Viruses, Coronaviruses, Adenoviruses, and Enteroviruses. August 5, ... Among the recently emerged respiratory pathogens are influenza viruses, coronaviruses, enteroviruses, and adenoviruses. As the ...
There are more than 50 types of immunologically distinct adenoviruses that can cause infections in humans. Adenoviruses most ... There is no specific treatment for adenovirus infections.. Adenovirus type 41 commonly causes pediatric acute gastroenteritis, ... While there have been case reports of hepatitis in immunocompromised children with adenovirus type 41 infection, adenovirus ... Case-finding efforts at this hospital identified four additional pediatric patients with hepatitis and adenovirus infection for ...
Infection kinetics of human adenovirus serotype 41 in HEK 293 cells.. Memorias do Instituto Oswaldo Cruz (2009) 104 (5) : 736- ... Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection. Immunity ( ... Protein transduction into human cells by adenovirus dodecahedron using WW domains as universal adaptors.. Journal of Gene ... Structure of the dodecahedral penton particle from human adenovirus type 3.. Journal of Molecular Biology (2006) 356 (2) : 510- ...
Aerosols of MS-2, human adenovirus type 1, and avian influenza virus were sampled size-selectively using a non-viable Andersen ... Viral-infections; Humans; Airborne-particles; Survival-rate; Bacterial-cultures; Bacteria; Cell-culture-techniques; Cell- ... The quantification of live viruses (avian influenza virus, swine influenza virus, avian metapneumovirus, human adenovirus type ... We conducted a study by aerosolizing MS-2 suspended in human saliva and found that actual human saliva was much less protective ...
DNA hybridization for diagnosis of enteric adenovirus infection from directly spotted human fecal specimens. J Clin Microbiol ... Adenovirus. Endemic disease. Adenoviruses are widely recognized causes of respiratory, ocular, and genitourinary infections. ... Infections occur throughout the year with no clear peaks (25). Other serotypes of adenovirus, particularly 31, have also been ... Human rotavirus studies in volunteers: determination of infectious dose and serological response to infection. J Infect Dis ...
Frontiers in Cellular and Infection Microbiology - 2021-01-01 * The structure of enteric human adenovirus 41-A leading cause of ... Subpopulations of extracellular vesicles from human metastatic melanoma tissue identified by quantitative proteomics after ...
What is the role of adenoviruses in human health? With advances in molecular biology informing recent developments in ... A new study describes the association between monkeypox infection and eye complications in humans. ... human adenoviruses (HAdVs) have been of primary importance in medical research. A recent review looks at the promises of HAdVs ... The ability to sequence the genomes of these models is a powerful tool to study the genetic factors that impact human health. ...
The ability of green- tea catechins to inhibit adenovirus infection and adenain, the human adenovirus 2 endopeptidase, was ... If a human corrects your grammar you can be sure they checked it and didnt see mistakes. Humans arent perfect, though, so of ... Gut microbes can fight parasites: Probiotics may reduce infections, and severity of infections, in developing countries. Date: ... Ear infections: The misinformed believe that ear infections start from outside the ear. The truth is that they are caused by ...
A fatal case of viral sepsis and encephalitis in a child caused by human adenovirus type 7 infection Adenoviruses are highly ... Adeno-associated virus infection and its impact in human health: an overview Discovered as a contaminant of adenovirus stocks ... Death from human cytomegalovirus infection in a girl with congenital thymic dysplasia We report the case of a girl with ... However, adenovirus infection is... Authors: Hongwei Zhao, Yingchao Liu, Ziheng Feng, Qianyu Feng, Kechun Li, Hengmiao Gao, ...
Beyond the human cost of more than 8 million infected people with 437,000-plus deaths, the damage to the world economy will ... Level 2 represents the subset of viruses that "jump" from insects or animals to humans causing infections and disease. ... adenovirus, enterovirus, human metapneumovirus, parainfluenza, and respiratory syncytial virus are other viruses that cause ... How Are Humans Infected by Viruses?. Most viruses do not infect or cause disease in humans. The pathogen pyramid (see Figure 1 ...
  • Other detected viruses included enterovirus/rhinovirus, metapneumovirus, respiratory syncytial virus, and human coronavirus OC43. (
  • Ten new chapters added to this edition cover Zika virus, rhinovirus, coagulase-negative staphylococcal infections, and more. (
  • However, during periods of low influenza activity and outside of epidemics situations, the infection of other respiratory viruses e.g. rhinovirus, respiratory syncytial virus, parainfluenza and adenovirus can also present as Influenza-like Illness (ILI) which makes the clinical differentiation of influenza from other pathogens difficult. (
  • Because of its acid sensitivity and low optimum growth temperature (33°C), EV68 shares characteristics with human rhinovirus (HRV) (3,6) and is genetically and antigenically similar to HRV 87 (6,7). (
  • Common viral causes of pneumonia include Respiratory Syncytial virus, Influenza and B, Parainfluenza, Human metapneumovirus and Adenovirus. (
  • thus, we strongly advise and encourage vaccinating for as many of them as possible, including the available bivalent vaccine for H3N8 and H3N2, in addition, to a current (within the past 6 months) intranasal Bordetella/Adenovirus/Parainfluenza vaccine . (
  • The patient is known to have co-infection with Influenza viruses or other viral respiratory infections (respiratory syncytial virus [RSV], parainfluenza viruses, respiratory adenoviruses). (
  • How Common Is Human Metapneumovirus? (
  • The laboratory evaluation of a nasal wash specimen done in the emergency room was positive for human metapneumovirus. (
  • One study in Finland found ~15% (5% for each group) of rapid virus detection specimens had adenovirus, human metapneumovirus and human bocavirus (a Parvoviridae virus causing respiratory infections identified in 2005). (
  • Human metapneumovirus (hMPV) is a single-stranded RNA virus in the Paramyxoviridae family that is closely related to avian metapneumovirus. (
  • The quantification of live viruses (avian influenza virus, swine influenza virus, avian metapneumovirus, human adenovirus type 1, and transmissible gastroenteritis virus) was accomplished by inoculation of appropriate cell culture systems. (
  • The team then found the same pattern in a larger group of blood and tissue cell samples from 2,939 people consisting of healthy controls and those infected with a diverse array of pathogens, including viruses such as SARS coronavirus, enterovirus and adenovirus, as well as bacteria such as Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae and Salmonella. (
  • Thirty-seven samples were checked for three types of human adenovirus, as well as rotavirus, enterovirus and fecal coliforms. (
  • Enterovirus 68 strains were detected in 14 specimens from children with respiratory tract infections and 1 specimen from a child with febrile convulsions during 2010 in Osaka, Japan. (
  • Enterovirus 68 (EV68) belongs to the family Picornaviridae, genus Enterovirus, and species Human enterovirus D (1). (
  • The scientists say they recognise that the virus may be just be one contributing factor in obesity but they suggest an understanding of how fat cells respond to infection could lead to vaccines to prevent weight gain. (
  • This is a new technology: no adenovirus vector vaccines for other diseases are yet widely available, though vaccines for HIV, influenza, Ebola and malaria using this platform are in clinical trials and an Ebola vaccine has been briefly deployed. (
  • MajhenD, Calderon H, Chandra N, Fajardo CA, Rajan A, Alemany R, Custers J. Adenovirus-based vaccines for fighting infectious diseases and cancer: progress in the field. (
  • This study aimed to evaluate the potency, toxicity, and protection of candidate PastoCoAd vaccines as novel mix and match of recombinant adenovirus type 5 (rAd5) containing the full-length spike protein (rAd5-S), rAd5 containing the receptor-binding domain of S protein and nucleoprotein (rAd5 RBD-N), and SOBERANA dimeric RBD protein of SARS-CoV-2. (
  • A downside, however, is that so far, no DNA or RNA vaccines have been licensed for human use, which may cause more hurdles with regulatory approval. (
  • Viral vector vaccines can mimic natural viral infection and should therefore trigger a strong immune response. (
  • While this is the first time we've seen international-scale vaccination programs, adenovirus vaccines are not new. (
  • Modern engineered vaccines - where a conspicuous bit of the target pathogen is placed like a passenger into the adenovirus chassis - have been used on thousands of individuals in trials to prevent Ebola, malaria, dengue, Marburg and HIV infections. (
  • MHC class II invariant chain-adjuvanted viral vectored vaccines enhances T cell responses in humans. (
  • Vaccination was well tolerated and enhanced the peak magnitude, breadth, and proliferative capacity of anti-HCV T cell responses compared to non-Ii vaccines in humans. (
  • This strategy could be used to develop more potent HCV vaccines that may contribute to the HCV elimination targets and paves the way for developing class II Ii vaccines against cancer and other infections. (
  • As you can see form this list, these CDC-approved vaccines are deliberately formulated with all sorts of highly toxic and questionable ingredients, including acetone, a toxic solvent, aluminum, artificial coloring chemicals, human blood components, dextrose (probably from GMO corn), cow blood components and a whole lot more. (
  • Are these vaccines made with African Green Monkey kidney cells and aborted human fetal cells really used in the United States? (
  • This page from the FDA lists all the vaccines which are "licensed for use in the United States," and it includes the vaccines containing African Green Monkey kidney cells and the WI-38 aborted human fetal cells. (
  • Immunosuppressives may diminish therapeutic effects of vaccines and increase risk of adverse effects (increased risk of infection). (
  • Adenoviruses are not the only viral vectors that can be used: pharmaceutical giant Merck says it is working on a potential COVID vaccine using an engineered vesicular stomatis virus , previously used successfully in its Ebola vaccine. (
  • The earliest viruses to be studied as vectors were retroviruses and adenoviruses. (
  • Subsequently many other viruses, both human and non-human pathogens, have been explored for their properties as vectors. (
  • The source of adenoviruses are diseased people (regardless of the form of the disease - hidden, inapparent, obvious) and healthy vectors. (
  • (1) AAV vectors are the leading platform for gene delivery for the treatment of a variety of human diseases. (
  • Most humans are immune to Ad5, so lower-seroprevalence viruses like human Ad6 and Ad26 are being tested as therapeutic vectors. (
  • Although adenoviruses cause human ailments such as respiratory infections, conjunctivitis and enteric dysentery, they can also be used as vectors in human gene therapy to combat sickness. (
  • Adenoviruses are a family of related viruses which cause mild infections in people and which have been converted into gene transfer vectors by blocking their ability to replicate in cells. (
  • In fact, adenoviruses are one of the most common vectors in use in gene therapy clinical trials because they are easy to work with, safe and are efficient at delivering genes to cells and tissues in the body. (
  • These experiments will help our further understanding of adenoviruses and ultimately lead to more optimal and safe vectors for all adenoviral gene therapy approaches. (
  • Adenoviral vectors, particularly human serotype 5 (of 58 individual serotypes), are widely used for gene therapy due to versatile tropism, large transgene capacity and ability to achieve efficient transgene without risk of insertional mutagenesis. (
  • E1 deleted adenoviruses are considered to be replication-defective and are used as shuttle vectors in gene therapy or vaccination for gene therapy and vaccine immunization. (
  • Adenovirus vectors generally have four strategies to achieve conditional replication: E1A specific promoter regulation, E1A CR2 deletion, E1A 13S CR3 deletion and E1B-55K deletion. (
  • We now assess this strategy in humans, using chimpanzee adenovirus 3 and modified vaccinia Ankara vectors encoding human Ii fused to the nonstructural (NS) antigens of hepatitis C virus (HCV) in a heterologous prime/boost regimen. (
  • An additional four children were identified, for a total of nine patients with hepatitis of unknown etiology and concomitant adenovirus infection during October 2021-February 2022. (
  • This Health Advisory serves to notify US clinicians who may encounter pediatric patients with hepatitis of unknown etiology to consider adenovirus testing and to elicit reporting of such cases to state public health authorities and to CDC. (
  • Clinicians should consider adenovirus testing in pediatric patients with hepatitis of unknown etiology. (
  • Fortunately, newer diagnostic laboratory methods have also added much-needed capacity to identify the presence and types of pathogens, often early enough in the SOT recipient's course to prevent or mitigate severe infection. (
  • Human adenoviruses (HAdVs) are highly contagious pathogens of clinical importance, especially among the pediatric population. (
  • Although microbiologically contaminated surfaces can serve as reservoirs of potential pathogens, these surfaces generally are not directly associated with transmission of infections to either staff or patients. (
  • In addition to SARS, other respiratory pathogens have also emerged recently, contributing to the high burden of respiratory tract infection-related morbidity and mortality. (
  • Other recently identified pathogens include the enteric adenoviruses, calicivirus, astrovirus, and the Norwalk family of agents. (
  • Both are normal human pathogens, the former including the HIV virus and the latter causing upper respiratory tract infections or colds. (
  • When pathogens infect the cells of the body, the infection sets off a chain reaction involving the immune system that changes the expression of hundreds of genes. (
  • Adenovirus pneumonia among immunocompetent adults is still relatively infrequent and therefore attracts considerable attention ( 4 ). (
  • He was given a diagnosis of adenovirus pneumonia, acute heart failure, and respiratory failure that required veno−venous extracorporeal membrane oxygenation during December 14−19. (
  • Acute respiratory infections particularly clinical pneumonia are one of the most common causes of death world-wide. (
  • These include pneumonia and croup , an infection that causes hoarse, barking coughs . (
  • Streptococcal Infections Streptococci are gram-positive aerobic organisms that cause many disorders, including pharyngitis, pneumonia, wound and skin infections, sepsis, and endocarditis. (
  • EV68 was isolated from 4 children with pneumonia and bronchiolitis in the United States in 1962 (prototype Fermon strain) (2,3) and is associated with respiratory tract infections (RTIs) (3-5). (
  • The severity of illness with canine flu in dogs can range from no signs of infection to severe damage to lungs via pneumonia. (
  • Pneumococcal disease can cause serious infections in the lungs (pneumonia), the bloodstream (bacteremia), and the lining of the brain and spinal cord (meningitis). (
  • This case was confirmed to have fatal pneumonia caused by ExPEC that led to a systemic infection. (
  • Human adenoviruses (HAdVs) cause ocular infections. (
  • With advances in molecular biology informing recent developments in vaccinology, gene therapy, and other fields of medicine, human adenoviruses (HAdVs) have been of primary importance in medical research. (
  • Human adenoviruses ( HAdVs ) represent a ubiquitous and clinically important pathogen without an effective antiviral treatment. (
  • Rhesus macaques inoculated with an adenovirus-associated virus (AAV) recombinant containing the gene for eCD4-Ig were protected from infection with large amounts of virus for up to 34 weeks after immunization. (
  • Intervention1: Asunercept: APG101 (Asunercept) is a recombinant glycosylated fusion protein consisting of the extracellular domain of human CD95 linked to the Fc domain of human IgG1 (CD95-Fc). (
  • Human adenovirus 7d, a genomic variant with no reported circulation in the United States, was isolated from 2 adults with severe respiratory infections in Illinois. (
  • In particular, respiratory infections with human adenovirus 7 (HAdV7) have a well-documented association with severe clinical manifestations, nosocomial transmission, prolonged hospitalizations, pulmonary sequela, and deaths ( 1 − 6 ). (
  • We report characterization of adenovirus strains isolated from 2 adults in the same family who had severe respiratory infections in Illinois, USA, during December 2014. (
  • Admission chest radiographs of 2 adults with severe infections with adenovirus type 7 in family, Illinois, USA, 2014. (
  • During October-November 2021, clinicians at a children's hospital in Alabama identified five pediatric patients with severe hepatitis and adenovirus viremia upon admission. (
  • This is the first report of a previously healthy adult in whom Human herpesvirus 6 reactivation induced this syndrome with severe hemodynamic and respiratory distress. (
  • There are such forms of adenovirus infection: mild, moderate and severe (the latter happens with or without complications). (
  • Clinical management of severe acute respiratory infection when Middle East respiratory syndrome coronavirus (MERS-CoV) infection is suspected. (
  • Hospital-based surveillance for severe acute respiratory infection (SARI) cases was established in New Zealand on 30 April 2012. (
  • There are very few viruses that we have medicines for at this time (influenza and severe herpes virus infections are two exceptions. (
  • Despite substantial efforts, no effective treatment has been discovered for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection. (
  • Severe acute respiratory syndrome-related coronavirus ( SARSr-CoV or SARS-CoV ) [note 1] is a species of virus consisting of many known strains phylogenetically related to severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) that have been shown to possess the capability to infect humans , bats , and certain other mammals . (
  • Two strains of the virus have caused outbreaks of severe respiratory diseases in humans: severe acute respiratory syndrome coronavirus 1 (SARS-CoV or SARS-CoV-1), which caused the 2002-2004 outbreak of severe acute respiratory syndrome (SARS), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is causing the ongoing pandemic of COVID-19 . (
  • Epstein-Barr virus (EBV) is a wide-spread human herpesvirus that is highly associated with infectious mononucleosis and several malignancies. (
  • Instead, the test results found high counts of active and infectious human adenoviruses, which multiply in the intestinal and respiratory tracts of people. (
  • Adenovirus infection belongs to the group of airborne and intestinal infections (according to the epidemiological classification of infectious diseases). (
  • This study seeks to better understand a potential role for adenovirus in infectious MS and discover novel therapeutic targets for the virus. (
  • Infectious Mononucleosis Infectious mononucleosis is caused by Epstein-Barr virus (EBV, human herpesvirus type 4) and is characterized by fatigue, fever, pharyngitis, and lymphadenopathy. (
  • Rapid diagnosis of infectious bursal disease infection by immunofluorescence on clinical material. (
  • Adenoviruses, which exist in the wild in humans and typically cause mild infections such as the common cold, have been genetically engineered to express viral antigens found in SARS-CoV-2, usually those of the infamous spike protein that the coronavirus uses to break into human cells. (
  • COVID-19 has RNA genetic material and is part of the coronavirus family, which causes respiratory infections. (
  • Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia. (
  • Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans, Saudi Arabia, 2014. (
  • MERS: emergence of a novel human coronavirus. (
  • State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans. (
  • 11. Memish ZA, Zumla AI, Assiri A. Middle East respiratory syndrome coronavirus infections in health care workers. (
  • One coronavirus, 6 astroviruses, and 1 novel adenovirus were identified and monitored quantitatively. (
  • TNFSF14 can be a cytokine neutralization target during novel coronavirus infection, and anti-TNFSF14 monoclonal antibody treatment can reduce the risk of respiratory failure and mortality. (
  • [16] Only recently have strains of SARS-related coronavirus been observed to have evolved into having been able to make the cross-species jump from bats to humans, as in the case of the strains SARS-CoV-1 and SARS-CoV-2 . (
  • Two respiratory specimens were positive for adenovirus by PCR. (
  • Clinical records from the hospital were reviewed to identify patients seen on or after October 1, 2021, with hepatitis and an adenovirus infection, detected via real-time polymerase chain reaction (PCR) testing on whole blood specimens, and no other known cause for hepatitis. (
  • Adenovirus was detected in whole blood specimens from all patients by real-time PCR testing (initial viral load range = 991-70,680 copies/mL). (
  • Hexon gene hypervariable region sequencing was performed on specimens from five patients, and adenovirus type 41 was detected in all five specimens. (
  • PCR) is preferred for adenovirus detection and may be performed on respiratory specimens, stool or rectal swabs, or blood. (
  • Proper collection, storage and transport of respiratory specimens is the essential first step for laboratory detection of influenza virus infections. (
  • Timely communication between clinical and laboratory staff is essential to minimize the potential risk of handling specimens from patients with possible SARS-CoV-2 infection. (
  • therefore, testing of whole blood could be considered in those without an etiology who tested negative for adenovirus in plasma samples. (
  • 500 U/L) who have an unknown etiology for their hepatitis (with or without any adenovirus testing results, independent of the results) since October 1, 2021. (
  • The UVRI is the largest Government Research Institution in Uganda dealing in health research pertaining to human infections and disease processes associated with or linked to viral etiology and is host to a number of partner organizations including those funded by US CDC, US NIH, MRC-UK and IAVI, as well as national and regional reference laboratories. (
  • To develop a novel therapeutic strategy for human pancreatic cancer using a midkine promoter-based conditionally replicating adenovirus. (
  • Oncolytic adenovirus is a type of conditionally replicating adenovirus. (
  • A nasal swab specimen obtained at admission to NMH was positive for adenovirus B/E by the GenMarkDx eSensor Respiratory Virus Panel (Genmark Diagnostics, Inc., Carlsbad, CA, USA). (
  • A BAL specimen obtained on December 17 was positive for adenovirus B/E by PCR. (
  • In November 2021, clinicians at a large children's hospital in Alabama notified CDC of five pediatric patients with significant liver injury, including three with acute liver failure, who also tested positive for adenovirus. (
  • All patients received negative test results for hepatitis viruses A, B, and C, and several other causes of pediatric hepatitis and infections were ruled out including autoimmune hepatitis, Wilson disease, bacteremia, urinary tract infections, and SARS-CoV-2 infection. (
  • Common bacterial infections include things like strep throat, impetigo, urinary tract infections, some pneumonias and bronchial infections, and many ear infections. (
  • The main clinical syndromes for adenovirus infection are: catarrh of the upper respiratory tract, tonsillopharyngitis, pharyngoconjunctival fever, keratoconjunctivitis, diarrhea and mesenteric lymphoadenitis. (
  • Qatar of the upper respiratory tract is the most common clinical variant of adenoviral infection in a child. (
  • Adenoviruses are common causative agents of upper respiratory illnesses, while they are associated with more serious clinical syndromes in the gastrointestinal tract. (
  • Following the precedent established by the comprehensive earlier metabolomic studies on HCMV, the potential role of adenovirus in metabolic diseases can be investigated and novel therapeutic targets in patients with clinical adenovirus infection can be tested. (
  • As of August 2022, the U.S. FDA and the WHO recommend not to use Ivermectin for SARS-CoV-2 virus infections or COVID-19 treatments except in the context of a clinical trial. (
  • Disease characteristics, clinical manifestations, and epidemiology generally mimic those of enteroviral infections. (
  • The associated clinical findings in enteroviral infections may include pharyngitis, pleurodynia, rash, and pericarditis. (
  • Our findings emphasize that SARS-CoV-2 infection significantly alters immune responses and innate and acquired immunity are differentially modulated in line with the clinical severity of the disease. (
  • Based on the typical clinical features, differential diagnosis for infection by Zika virus is widespread. (
  • Therefore, to reconstitute hCAR signaling pathways in vitro, we generated adenovirus vector expressing hCAR. (
  • The Chinese company CanSino Biologics - the medical science arm of the People's Liberation Army, no less - has completed Phase 1 trials with an adenovirus vector vaccine called Ad5-nCoV. (
  • HAdV-5 has been widely applied to human gene therapy as a vector for gene transfer, mainly because it can easily infect different human cells and can be produced in large quantities. (
  • Majhen D . Human adenovirus type 26 basic biology and its usage as vaccine vector. (
  • This allows the adenoviral vector to be used for gene therapy (the use of genes to treat human disease). (
  • Nonhuman primates and humans are probably the main reservoirs of the virus, and anthroponotic transmission (man-vector-man) occurs during outbreaks. (
  • One type of virus that has often been used as a vector is adenovirus, which causes the common cold. (
  • Human Immunodeficiency Virus and Heparan Sulfate : from attachment to entry inhibition. (
  • Viruses like Herpes simplex virus 1 deplete the host mitochondrial DNA and some, like human immunodeficiency virus, hijack the host mitochondrial proteins to function fully inside the host cell. (
  • Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (
  • Evaluation of on-line high-performance size-exclusion chromatography, differential refractometry, and multi-angle laser light scattering analysis for the monitoring of the oligomeric state of human immunodeficiency virus vaccine protein antigen. (
  • We examined midkine mRNA expression and midkine protein expression by seven human pancreatic cancer cell lines (AsPC-1, BxPC-3, CFPAC-1, HPAC, MIAPaCa-2, PANC-1, and Suit-2), as well as by non-cancerous pancreatic tissue and pancreatic cancers. (
  • Adenoviral transduction efficiency was assessed by fluorescent staining of cancer cell lines using adenovirus type 5 containing the green fluorescent protein gene (Ad5GFP). (
  • Replication of adenovirus type 5 containing the 0.6 kb midkne promoter (Ad5MK) was assessed by the detection of E1 protein in cancer cell lines. (
  • MajhenD , Richardson J, Vukelić B, Dodig I, Cindrić M, Benihoud K, Ambriović-Ristov A. The disulfide bond of an RGD4C motif inserted within the Hi loop of the adenovirus type 5 fiber protein is critical for retargeting to αv -integrins. (
  • Whether sustained production of the protein in humans will cause disease remains to be determined. (
  • All human infections caused by a new influenza subtype are required to be reported under the International Health Regulations (IHR, 2005).4 This includes any influenza A virus that has demonstrated the capacity to infect a human and its haemagglutinin gene (or protein) is not a mutated form of those, i.e. (
  • In the case of COVID-19, the antigen is typically the characteristic spike protein found on the surface of the virus, which it normally uses to help it invade human cells. (
  • Once this genetic material gets into human cells, it uses our cells' protein factories to make the antigen that will trigger an immune response. (
  • The CR2 region of the adenovirus E1A protein also interacts with pRB, E2F is released and the virus replicates. (
  • Adenovirus E2 promoter can be divided into early and late promoters, used to regulate the E2 transcription unit, the late E2 promoter region contains Y-box, the binding site of transcription factor YB-1 (Y-box binding protein-1). (
  • The E1B region of the adenovirus genome encodes a 55kD protein (E1B55K), which binds and inactivates TP53. (
  • Species B human adenoviruses are frequent causative agents of acute respiratory disease requiring hospitalization mainly for children but occasionally also for adults. (
  • Human adenovirus type 8 (HAdV-8) is one of the major serotypes isolated from patients with EKC. (
  • The investigations of these variants might be helpful for defining the evolutionary tendency and to predict future outbreaks of HAdV infection. (
  • Our work will explore the potential link between adenovirus infection and MS. HAdV-5 has been shown to cause obesity in animal models and HAdV-36 has been associated with obesity in humans. (
  • In twins discordant for infection with HAdV-36, the infected twins were heavier and fatter than their cotwins. (
  • There are currently 52 identified serotypes of human adenovirus, grouped into six categories (A through F). HAdV-5 is a group C virus and was first isolated and cultured from adenoid tissue in 1953. (
  • The first aim of this thesis work was to characterize the metabolic alterations in core metabolism during infection with HAdV-5. (
  • Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses. (
  • In 36 culture-proven cases of adenovirus ocular infection, direct Adenoclone testing of conjunctival swabs was positive in 24 of 31 patients (77%) tested within 1 week of onset of symptoms, and in one of five patients (20%) who presented after 1 week (P less than 0.02). (
  • A big-name corporate player is Johnson & Johnson, via its subsidiary Janssen, which uses a genetically modified human adenovirus technology it calls AdVac. (
  • This review delineates the current knowledge of the genetic landscape of the human tumors, its influence in the development of genetically engineered mouse models (GEMMs) and the molecular imaging tools available to detect and monitor these diseases. (
  • These data demonstrate shared as well as divergent life cycles in these genetically distant human adenoviruses. (
  • The authors conclude that a positive Adenoclone test is reliable in the rapid diagnosis of early adenovirus ocular infections. (
  • all five that were sequenced had adenovirus type 41 infection identified. (
  • Adenoviruses most commonly cause respiratory illness but depending on the adenovirus type they can cause other illnesses such as gastroenteritis, conjunctivitis, cystitis, and, less commonly, neurological disease [3]. (
  • While there have been case reports of hepatitis in immunocompromised children with adenovirus type 41 infection, adenovirus type 41 is not known to be a cause of hepatitis in otherwise healthy children [5, 6]. (
  • Aerosols of MS-2, human adenovirus type 1, and avian influenza virus were sampled size-selectively using a non-viable Andersen impactor. (
  • Mesenteric lymphadenitis (mesadenitis) is a type of adenoviral infection that occurs quite often. (
  • The main symptoms of this type of adenovirus are also fever and vomiting. (
  • Development of a low-seroprevalence, αvβ6 integrin-selective virotherapy based on human adenovirus type 10. (
  • Nestić D, Božinović K, Drašković I, Kovačević A, van den Bosch J, Knežević J, Custers J, Ambriović-Ristov A, Majhen D . Human Adenovirus Type 26 Induced IL-6 Gene Expression in an αvβ3 Integrin- and NF-κB-Dependent Manner. (
  • Nestić D, Uil TG, Ma J, Roy S, Vellinga J, Baker AH, Custers J, Majhen D. αvβ3 Integrin is Required for Efficient Infection of Epithelial Cells with Human Adenovirus Type 26. (
  • MajhenD, Stojanović N, Vukić D, Pichon C, Leduc C, Osmak M, Ambriović-Ristov A. Increased adenovirus Type 5 mediated transgene expression due to RhoB down-regulation. (
  • Majhen D , Nemet J, Richardson J, Gabrilovac J, Hajsig M, Osmak M, Eloit M, Ambriović-Ristov A. Differential role of alpha(v)beta(3) and alpha(v)beta(5) integrins in internalization and transduction efficacies of wild type and RGD4C fiber-modified adenoviruses. (
  • It tells you which type of infection you have. (
  • In recent years, oncolytic adenovirus therapy has become more and more important as a new type of treatment for various cancers. (
  • Canine Influenza (dog flu) is a highly contagious respiratory infection of dogs caused by specific Type-A influenza viruses known to infect dogs. (
  • The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with TMC-310911. (
  • AAV belongs to the parvovirus family and is dependent on co-infection with other viruses, mainly adenoviruses, in order to replicate. (
  • Influenza C virus is detected less frequently and usually causes mild infections, thus does not present public health importance. (
  • Adenovirus infection is an acute respiratory disease, accompanied by mild intoxication, fever. (
  • This is a common and usually mild respiratory infection. (
  • Most respiratory infections cause mild to moderate symptoms. (
  • In the period between flu epidemics, 25 to 30% of young children infected with viral diseases of the respiratory tract suffer from adenovirus infection. (
  • The reprogramming technology offers the opportunity to generate patient-specific stem cells for modeling human diseases, drug development and screening, and individualized regenerative cell therapy. (
  • Research shows that TNFSF14 plays a critical regulatory role in immune responses to viral infection, but its role is different in different diseases. (
  • Dmitry Kazansky: If the ban on human genetic modification is ever overcome, then humanity will get rid of hereditary diseases. (
  • The MRC Unit is one of the two MRC-UK Units outside of the United Kingdom and is a multidisciplinary programme studying the HIV epidemic in rural and urban settings, emerging and re-emerging infections and non-communicable diseases. (
  • Medication toxicities compounded by allograft rejection and complications of healthcare-acquired infections result in more complex presentations. (
  • What are the eye complications associated with monkeypox infection? (
  • A new study describes the association between monkeypox infection and eye complications in humans. (
  • You may need this test if you have symptoms of a respiratory infection and are at risk for complications. (
  • In normal non-cancer cells, the oncolytic adenovirus cannot replicate during infection, leaving the cell unaffected. (
  • Seasonal influenza is an acute respiratory infection caused by influenza viruses which circulate in all parts of the world. (
  • Currently circulating in humans are subtype A(H1N1) and A(H3N2) influenza viruses. (
  • The overall public health risk from currently known influenza viruses at the human-animal interface has not changed, and the likelihood of sustained human-to-human transmission of these viruses remains low. (
  • It is a never-before seen combination of human, swine, and avian influenza viruses. (
  • The pathogen pyramid (see Figure 1) illustrates the interaction viruses have with humans. (
  • Other viral and bacterial tests for respiratory infections are often limited to testing for one specific pathogen. (
  • Several seminal studies have recently implicated bats as sources of important RNA viruses of humans and livestock, including lyssaviruses, coronaviruses (CoVs), filoviruses, henipaviruses, and astroviruses (AstVs) ( 2 , 4 ). (
  • Epidemic keratoconjunctivitis (EKC) is a contagious acute conjunctivitis associated with community-acquired infection. (
  • Adenoviruses are very common DNA viruses that infect us throughout our lifetime, causing colds, sore throats, bronchitis, diarrhoea or conjunctivitis. (
  • abstract = "Our understanding of adenovirus (Ad) biology is largely extrapolated from human species C Ad5. (
  • Since the last risk assessment on 21 May 2021, one new laboratory-confirmed human case of influenza A(H5N6) virus infection was reported from China to WHO on 30 May 2021. (
  • Studies were performed to compare the therapeutic effectiveness of three antiviral drugs (ARA-A, ARA-C and IDU) on the course of fatal disseminated vaccinia virus infection in immunosuppressed mice. (
  • HerpeS-simpleX-virus infection after renal transplantation. (
  • Because viruses must bind to cell surface molecules to initiate replication, the use of soluble receptors to block virus infection has long been an attractive therapeutic option. (
  • When hosts suffer influenza virus infection, the TNFSF14-HVEM signaling pathway can stimulate the maturation and proliferation of memory CD8+ T cells, which helps the host immune system stimulate a second immune response against respiratory virus infection. (
  • During hepatitis virus infection, TNFSF14 acts as a proinflammatory factor, participates in inflammation and causes tissue damage. (
  • On November 28, the Texas Department of State Health Services reported the state's first case of local mosquito-borne Zika virus infection in Brownsville. (
  • The advantages of the combination of nanotechnology and targeting strategies in combating bacterial infections are highlighted in this review, and the upcoming opportunities and remaining challenges in this field are rationally prospected. (
  • The pattern of changes, which they call the meta-virus signature, occurs in a range of viruses and is distinct from the pattern of gene expression in healthy people or in people with bacterial infections. (
  • The influenza meta-signature pattern can distinguish flu from other viral infections, as well as from bacterial infections. (
  • Khatri said his team was motivated by the long-term goal of finding broad-spectrum antiviral drugs, much like the broad-spectrum antibiotics that have saved so many people from deadly bacterial infections. (
  • Bacterial infections often follow a viral infection, such as an ear or sinus infection following a "cold. (
  • [17] [4] Both of these strains descended from a single ancestor but made the cross-species jump into humans separately. (
  • early detection at the human-animal interface will provide earlier warning. (
  • Effect of disease state on ionization during bioanalysis of MK-7009, a selective HCV NS3/NS4 protease inhibitor, in human plasma and human Tween-treated urine by high-performance liquid chromatography with tandem mass spectrometric detection. (
  • Detection of fungi that can cause organic fluids infections. (
  • Hepatitis is inflammation of the liver that can be caused by viral infections, alcohol use, toxins, medications, and certain other medical conditions. (
  • although it can also be caused by viral infections. (
  • Overview of Viral Respiratory Infections Viral infections commonly affect the upper or lower respiratory tract. (
  • The diagnosis of infection is made more arduous since SOT recipients may present with more than one infection or at later stages in the disease process or may experience drug toxicity from immunosuppressive agents, as well as from antibiotics. (
  • Laboratory Diagnosis of Respiratory Tract Infections in Children - the State of the Art. (
  • It is also possible infection, similar in mechanism to infection with intestinal infections. (
  • The U.S. CDC says Ivermectin is indicated to treat the following infections: Strongyloidiasis of the intestinal tract. (
  • Purvesh Khatri , PhD, assistant professor of medicine, and a team of six other researchers at Stanford identified 396 human genes whose expression changes in a consistent pattern that reveals the presence of a viral infection. (
  • This second pattern, the influenza meta-signature, consists of a change in the expression of just 11 human genes. (
  • In blood samples from 205 people infected with a flu, cold or respiratory syncytial virus, the team found 396 genes whose expression changed in the same way during all three types of infections, with an increase in the expression of 161 genes and a decrease in the expression of 235 genes. (
  • In the larger group, the team found the same altered pattern of expression in the same 396 genes among patients with viral infections. (
  • Dmitry Kazansky: Human blood is taken, lymphocytes are separated from other cells, then artificial viral constructs are used to introduce the necessary genes into lymphocytes. (
  • Most wheeze in preschool children is associated with viral upper respiratory tract infections, which recur frequently in this age group. (
  • In the absence of active sentinel surveillance for adenovirus infections, there is no current sense of what the actual burden of adenovirus-associated respiratory disease is in the United States or which are the most prevalent pathogenic types circulating in this country. (
  • Adenovirus-36 (Ad-36)-one strain in a family of about fifty adenoviruses that are responsible for colds, respiratory infections, and eye infections-was first linked to weight gain when Nikhil Dhurandhar, now a professor at Louisiana State University, noticed that chickens infected with Ad-36 became plump instead of wasting away with disease. (
  • To better understand how this might impact their biology, we examined the life cycle of the two viruses in human lung cells in vitro. (
  • It seems that when there is a viral infection, the immune system turns on a general response to all viruses, followed by a virus-specific response to the particular virus. (
  • The adenovirus is designed to induce the immune system to generate a protective response against SARS-2. (
  • Liver biopsies from six patients demonstrated various degrees of hepatitis with no viral inclusions observed, no immunohistochemical evidence of adenovirus, or no viral particles identified by electron microscopy. (
  • The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to notify clinicians and public health authorities of a cluster of children identified with hepatitis and adenovirus infection. (
  • A possible association between pediatric hepatitis and adenovirus infection is currently under investigation. (
  • Cases of pediatric hepatitis in children who tested negative for hepatitis viruses A, B, C, D, and E were reported earlier this month in the United Kingdom, including some with adenovirus infection [1]. (
  • An AP analysis of water quality revealed dangerously high levels of viruses and bacteria from human sewage in Olympic and Paralympic venues - results that alarmed international experts and dismayed competitors training in Rio, some of whom have already fallen ill with fevers, vomiting and diarrhea. (
  • Both viruses and bacteria cause infections and illness, including possible fever. (