Virus diseases caused by the ADENOVIRIDAE.
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.

Adenoviral gene transfer of the human V2 vasopressin receptor improves contractile force of rat cardiomyocytes. (1/761)

BACKGROUND: In congestive heart failure, high systemic levels of the hormone arginine vasopressin (AVP) result in vasoconstriction and reduced cardiac contractility. These effects are mediated by the V1 vasopressin receptor (V1R) coupled to phospholipase C beta-isoforms. The V2 vasopressin receptor (V2R), which promotes activation of the Gs/adenylyl cyclase system, is physiologically expressed in the kidney but not in the myocardium. Expression of a recombinant V2R (rV2R) in the myocardium could result in a positive inotropic effect via the endogenous high concentrations of AVP in heart failure. METHODS AND RESULTS: A recombinant adenovirus encoding the human V2R (Ad-V2R) was tested for its ability to modulate the cardiac Gs/adenylyl cyclase system and to potentiate contractile force in rat ventricular cardiomyocytes and in H9c2 cardiomyoblasts. Ad-V2R infection resulted in a virus concentration-dependent expression of the transgene and led to a marked increase in cAMP formation in rV2R-expressing cardiomyocytes after exposure to AVP. Single-cell shortening measurements showed a significant agonist-induced contraction amplitude enhancement, which was blocked by the V2R antagonist, SR 121463A. Pretreatment of Ad-V2R-infected cardiomyocytes with AVP led to desensitization of the rV2R after short-term agonist exposure but did not lead to further loss of receptor function or density after long-term agonist incubation, thus demonstrating resistance of the rV2R to downregulation. CONCLUSIONS: Adenoviral gene transfer of the V2R in cardiomyocytes can modulate the endogenous adenylyl cyclase-signal transduction cascade and can potentiate contraction amplitude in cardiomyocytes. Heterologous expression of cAMP-forming receptors in the myocardium could lead to novel strategies in congestive heart failure by bypassing the desensitized beta-adrenergic receptor signaling.  (+info)

A single amino acid in the adenovirus type 37 fiber confers binding to human conjunctival cells. (2/761)

A 46-kDa receptor, coxsackievirus-adenovirus (Ad) receptor (CAR), mediates cell attachment of a number of different Ad serotypes; however, not all Ad serotypes utilize this receptor for infection. Moreover, the precise amino acid sequences in the Ad fiber protein that mediate cell attachment have yet to be identified. We investigated the interaction of subgroup D Ads with human ocular cells. Ad serotype 37 (Ad37), a virus associated with epidemic keratoconjunctivitis, but not a closely related virus serotype, Ad19p, exhibited preferential binding to and infection of human conjunctival cells. A single amino acid substitution in the Ad19p fiber distal domain (knob), Glu240 to Lys, conferred binding to conjunctival cells, while the reverse substitution in the Ad37 fiber abrogated cell binding. These findings provide new information on the fiber sequences that regulate Ad host cell tropism.  (+info)

Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction. (3/761)

BACKGROUND: The use of molecular biological techniques has demonstrated the importance of enteroviral infection of the myocardium in the pathogenesis of myocarditis and dilated cardiomyopathy in adults and adenovirus and enterovirus infection in children. The aim of this study was to determine the frequency of adenoviral infection of the myocardium of adults with impaired left ventricular function of unknown origin. METHODS AND RESULTS: Nested polymerase chain reaction (nPCR) was used to determine the frequency of detection of adenoviral DNA and enteroviral RNA in myocardial tissue samples from 94 adult patients with idiopathic left ventricular dysfunction and 14 control patients. Histological and immunohistological analyses were performed to detect myocardial inflammation. Adenoviral genomic DNA was detected by nPCR in 12 of the 94 patients with left ventricular dysfunction (in each case, adenovirus type 2), whereas enteroviral RNA was detected in another 12 patients. All control samples were negative for both viruses. In all patients, active myocarditis was excluded according to the Dallas criteria. However, there was significantly decreased CD2, CD3, and CD45RO T lymphocyte counts in the adenovirus-positive group compared with the adenovirus-negative group (P<0.05), whereas no differences were associated with enterovirus infection. CONCLUSIONS: Although enteroviruses are an important causative agent in the pathogenesis of myocarditis and dilated cardiomyopathy, this study shows that adenovirus infection is also important in the pathogenesis of left ventricular failure in adults. However, the pathogenetic basis of disease associated with adenovirus infection may be different than that after infection with other agents, particularly with respect to activation of the host immune response.  (+info)

Adenovirus infection after pediatric bone marrow transplantation. (4/761)

Retrospective analysis of 206 patients undergoing 215 consecutive bone marrow transplants (BMT) at St Jude Children's Research Hospital between November 1990 and December 1994 identified 6% (seven male, six female) with adenovirus infection. The affected patients had a median age of 7.9 years (range 3-24 years) at time of transplantation. Although transplants were performed for hematologic malignancies, solid tumors or nonmalignant conditions, only patients with hematologic malignancies had adenoviral infections. Adenovirus was first detected at a median of 54 days (range -4 to +333) after BMT. Adenovirus developed in eight of 69 (11.6%) patients receiving grafts from matched unrelated or mismatched related donors, in four of 52 (7.7%) receiving grafts from HLA-matched siblings, and in one of 93 (1.1%) receiving autografts. The most common manifestation of adenovirus infection was hemorrhagic cystitis, followed by gastroenteritis, pneumonitis and liver failure. The incidence of adenovirus infection in pediatric BMT patients at our institution is similar to that reported in adult patients. Using univariate analysis, use of total body irradiation and type of bone marrow graft were significant risk factors for adenovirus infection. Only use of total body irradiation remained as a factor on multiple logistic regression analysis.  (+info)

Lesions and transmission of experimental adenovirus hemorrhagic disease in black-tailed deer fawns. (5/761)

Adenovirus infection was the cause of an epizootic of hemorrhagic disease that is believed to have killed thousands of mule deer (Odocoileus hemionus) in California during the latter half of 1993. A systemic vasculitis with pulmonary edema and hemorrhagic enteropathy or a localized vasculitis associated with necrotizing stomatitis/pharyngitis/glossitis or osteomyelitis of the jaw were common necropsy findings in animals that died during this epizootic. To study transmission of adenovirus infection in deer and susceptibility of black-tailed deer (Odocoileus hemionus columbianus) fawns to adenovirus infection, six 3-6-month-old black-tailed fawns were divided into two treatment groups. One group was inoculated intravenously and the other group was inoculated through the mucous membranes of the eyes, nose and mouth with purified adenovirus. Each treatment group also included two additional fawns (four total) that were not inoculated but were exposed to inoculated animals (contact animals). One fawn served as a negative control. Between 4 and 16 days postinoculation, 8/10 fawns developed systemic or localized infection with lesions identical to lesions seen in animals with natural disease that died during the epizootic. Transmission was by direct contact, and the route of inoculation did not affect the incubation period or the distribution of the virus (systemic or the localized infection). Immunohistochemical analysis using polyclonal antiserum against bovine adenovirus type 5 demonstrated staining in endothelial cells of vessels in numerous tissues in animals with systemic infection and endothelial staining only in vessels subtending necrotic foci in the upper alimentary tract in animals with the localized form of the disease. All inoculated or exposed animals had staining in the tonsillar epithelium. Transmission electron microscopic examination of lung and ileum from two fawns with pulmonary edema and hemorrhagic enteropathy demonstrated endothelial necrosis and adenovirus virions in endothelial cell nuclei. Adenovirus was reisolated in black-tailed deer pulmonary artery endothelial cells using lung homogenate of the first fawn that developed systemic adenovirus infection. Serum virus neutralization test results suggest that this deer adenovirus is a new serotype.  (+info)

Gene transfer to human pancreatic endocrine cells using viral vectors. (6/761)

We have studied the factors that influence the efficiency of infection of human fetal and adult pancreatic endocrine cells with adenovirus, murine retrovirus, and lentivirus vectors all expressing the green fluorescent protein (Ad-GFP, MLV-GFP, and Lenti-GFP, respectively). Adenoviral but not retroviral vectors efficiently infected intact pancreatic islets and fetal islet-like cell clusters (ICCs) in suspension. When islets and ICCs were plated in monolayer culture, infection efficiency with all three viral vectors increased. Ad-GFP infected 90-95% of the cells, whereas infection with MLV-GFP and Lenti-GFP increased only slightly. Both exposure to hepatocyte growth factor/scatter factor (HGF/SF) and dispersion of the cells by removal from the culture dish and replating had substantial positive effects on the efficiency of infection with retroviral vectors. Studies of virus entry and cell replication revealed that cell dispersion and stimulation by HGF/SF may be acting through both mechanisms to increase the efficiency of retrovirus-mediated gene transfer. Although HGF/SF and cell dispersion increased the efficiency of infection with MLV-GFP, only rare cells with weak staining for insulin were infected, whereas approximately 25% of beta-cells were infected with Lenti-GFP. We conclude that adenovirus is the most potent vector for ex vivo overexpression of foreign genes in adult endocrine pancreatic cells and is the best vector for applications where high-level but transient expression is desired. Under the optimal conditions of cell dispersion plus HGF/SF, infection with MLV and lentiviral vectors is reasonably efficient and stable, but only lentiviral vectors efficiently infect pancreatic beta-cells.  (+info)

Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. (7/761)

To understand the function of specific proteins in sensory hair cells, it is necessary to add or inactivate those proteins in a system where their physiological effects can be studied. Unfortunately, the usefulness of heterologous expression systems for the study of many hair cell proteins is limited by the inherent difficulty of reconstituting the hair cell's exquisite cytoarchitecture. Expression of exogenous proteins within hair cells themselves may provide an alternative approach. Because recombinant viruses were efficient vectors for gene delivery in other systems, we screened three viral vectors for their ability to express exogenous genes in hair cells of organotypic cultures from mouse auditory and vestibular organs. We observed no expression of the genes for beta-galactosidase or green fluorescent protein (GFP) with either herpes simplex virus or adeno-associated virus. On the other hand, we found robust expression of GFP in hair cells exposed to a recombinant, replication-deficient adenovirus that carried the gene for GFP driven by a cytomegalovirus promoter. Titers of 4 x 10(7) pfu/ml were sufficient for expression in 50% of the approximately 1,000 hair cells in the utricular epithelium; < 1% of the nonhair cells in the epithelium were GFP positive. Expression of GFP was evident as early as 12 h postinfection, was maximal at 4 days, and continued for at least 10 days. Over the first 36 h there was no evidence of toxicity. We recorded normal voltage-dependent and transduction currents from infected cells identified by GFP fluorescence. At longer times hair bundle integrity was compromised despite a cell body that appeared healthy. To assess the ability of adenovirus-mediated gene transfer to alter hair cell function we introduced the gene for the ion channel Kir2.1. We used an adenovirus vector encoding Kir2.1 fused to GFP under the control of an ecdysone promoter. Unlike the diffuse distribution within the cell body we observed with GFP, the ion channel-GFP fusion showed a pattern of fluorescence that was restricted to the cell membrane and a few extranuclear punctate regions. Patch-clamp recordings confirmed the expression of an inward rectifier with a conductance of 43 nS, over an order of magnitude larger than the endogenous inward rectifier. The zero-current potential in infected cells was shifted by -17 mV. These results demonstrate an efficient method for gene transfer into both vestibular and auditory hair cells in culture, which can be used to study the effects of gene products on hair cell function.  (+info)

Tracheal aspirate as a substrate for polymerase chain reaction detection of viral genome in childhood pneumonia and myocarditis. (8/761)

BACKGROUND: Infectious respiratory disorders are important causes of childhood morbidity and mortality. Viral causes are common and may lead to rapid deterioration, requiring mechanical ventilation; myocardial dysfunction may accompany respiratory decompensation. The etiologic viral diagnosis may be difficult with classic methods. The purpose of this study was to evaluate polymerase chain reaction (PCR) as a diagnostic method for identification of causative agents. METHODS AND RESULTS: PCR was used to amplify sequences of viruses known to cause childhood viral pneumonia and myocarditis. Oligonucleotide primers were designed to amplify specific sequences of DNA virus (adenovirus, cytomegalovirus, herpes simplex virus, and Epstein-Barr virus) and RNA virus (enterovirus, respiratory syncytial virus, influenza A, and influenza B) genomes. Tracheal aspirate samples were obtained from 32 intubated patients and nucleic acid extracted before PCR. PCR results were compared with results of culture, serology, and antigen detection methods when available. In cases of myocarditis (n=7), endomyocardial biopsy samples were analyzed by PCR and compared with tracheal aspirate studies. PCR amplification of viral genome occurred in 18 of 32 samples (56%), with 3 samples PCR positive for 2 viral genomes. Amplified viral sequences included RSV (n=3), enterovirus (n=5), cytomegalovirus (n=4), adenovirus (n=3), herpes simplex virus (n=2), Epstein-Barr virus (n=1), influenza A (n=2), and influenza B (n=1). All 7 cases of myocarditis amplified the same viral genome from heart as found by tracheal aspirate. CONCLUSIONS: PCR is a rapid and sensitive diagnostic tool in cases of viral pneumonia with or without myocarditis, and tracheal aspirate appears to be excellent for analysis.  (+info)

Types of Adenoviridae Infections:

1. Respiratory adenovirus infection (bronchiolitis, pneumonia)
2. Gastroenteric adenovirus infection (gastroenteritis)
3. Eye adenovirus infection (conjunctivitis)
4. Skin adenovirus infection (keratoconjunctivitis)
5. Intestinal adenovirus infection (diarrhea, vomiting)
6. Adenovirus-associated hemorrhagic cystitis
7. Adenovirus-associated hypertrophic cardiomyopathy
8. Adenovirus-associated myocarditis

Symptoms of Adenoviridae Infections:

1. Respiratory symptoms (cough, fever, difficulty breathing)
2. Gastrointestinal symptoms (diarrhea, vomiting, abdominal pain)
3. Eye symptoms (redness, discharge, sensitivity to light)
4. Skin symptoms (rash, blisters, skin erosion)
5. Intestinal symptoms (abdominal cramps, fever, chills)
6. Cardiovascular symptoms (hypertension, tachycardia, myocarditis)

Diagnosis of Adenoviridae Infections:

1. Physical examination and medical history
2. Laboratory tests (rapid antigen detection, PCR, electron microscopy)
3. Imaging studies (chest X-ray, CT scan, MRI)
4. Biopsy (tissue or organ biopsy)

Treatment of Adenoviridae Infections:

1. Supportive care (fluids, oxygen therapy, pain management)
2. Antiviral medications (ribavirin, cidofovir)
3. Immune modulators (immunoglobulins, corticosteroids)
4. Surgical intervention (in severe cases of adenovirus-associated disease)

Prevention of Adenoviridae Infections:

1. Good hygiene practices (handwashing, surface cleaning)
2. Avoiding close contact with individuals who are infected
3. Properly storing and preparing food
4. Avoiding sharing of personal items (utensils, drinking glasses, towels)
5. Immunization (vaccination against adenovirus)

Incubation Period:
The incubation period for adenoviruses is typically between 3-7 days, but it can range from 1-2 weeks in some cases.

Contagious Period:
Adenoviruses are highly contagious and can be transmitted before symptoms appear and during the entire course of illness. The virus can be shed for several weeks after infection.

Risk Factors:
Individuals with weakened immune systems (children, elderly, those with chronic illnesses) are at a higher risk of developing severe adenovirus infections. Additionally, those who live in crowded or unsanitary conditions and those who engage in behaviors that compromise their immune system (smoking, excessive alcohol consumption) are also at a higher risk.

Complications:
Adenovirus infections can lead to a variety of complications, including pneumonia, meningitis, encephalitis, and other respiratory, gastrointestinal, and eye infections. In severe cases, adenovirus infections can be fatal.

Recovery Time:
The recovery time for adenovirus infections varies depending on the severity of the infection and the individual's overall health. Mild cases of adenovirus may resolve within a few days to a week, while more severe cases may take several weeks to recover from. In some cases, hospitalization may be necessary for individuals with severe infections or those who experience complications.

Contraception:
There is no specific contraceptive measure that can prevent adenovirus infections. However, practicing good hygiene, such as frequent handwashing and avoiding close contact with people who are sick, can help reduce the risk of transmission.

Pregnancy:
Adenovirus infections during pregnancy are rare but can be severe. Pregnant women who develop adenovirus infections may experience complications such as preterm labor and low birth weight. It is essential for pregnant women to seek medical attention immediately if they suspect they have an adenovirus infection.

Diagnosis:
Adenovirus infections can be diagnosed through a variety of tests, including polymerase chain reaction (PCR), electron microscopy, and culture. A healthcare provider will typically perform a physical examination and take a medical history to determine the likelihood of an adenovirus infection.

Treatment:
There is no specific treatment for adenovirus infections, but symptoms can be managed with supportive care such as hydration, rest, and over-the-counter pain relievers. Antiviral medications may be prescribed in severe cases or for individuals with compromised immune systems.

Prevention:
Preventing the spread of adenovirus is essential, especially in high-risk populations such as young children and those with weakened immune systems. Practicing good hygiene, such as frequent handwashing and avoiding close contact with people who are sick, can help reduce the risk of transmission. Vaccines are also available for some types of adenovirus.

Prognosis:
The prognosis for adenovirus infections is generally good, especially for mild cases. However, severe cases can lead to complications such as pneumonia, meningitis, and encephalitis, which can be life-threatening. In some cases, long-term health problems may persist after recovery from an adenovirus infection.

Complications:
Adenovirus infections can lead to various complications, including:

1. Pneumonia: Adenovirus can cause pneumonia, which is an inflammation of the lungs that can lead to fever, chest pain, and difficulty breathing.
2. Meningitis: Adenovirus can cause meningitis, which is an inflammation of the membranes surrounding the brain and spinal cord. Symptoms include headache, stiff neck, and sensitivity to light.
3. Encephalitis: Adenovirus can cause encephalitis, which is an inflammation of the brain that can lead to confusion, seizures, and coma.
4. Gastrointestinal symptoms: Adenovirus can cause gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain.
5. Long-term health problems: In some cases, adenovirus infections can lead to long-term health problems such as asthma, allergies, and autoimmune disorders.

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Infection is often subclinical, and when clinical signs are seen they are mild and short-lived.[citation needed] ... Porcine adenovirus (aka pADV 1-5 or pADV A-C) is a virus in the family Adenoviridae. It causes mild gastrointestinal diseases ... Respiratory signs such as coughing can be seen if the infection is part of a multifactorial respiratory disease complex.[ ... Adenoviridae, All stub articles, Veterinary medicine stubs). ...
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... of all respiratory infections, as well as gastrointestinal and eye infections. Symptoms are usually mild. Specific tropisms ... Mastadenovirus is a genus of viruses in the family Adenoviridae. Humans and other mammals serve as natural hosts. There are 51 ... The genus as a whole includes many very common causes of human infection, estimated to be responsible for 2 to 5% ... can cause potentially fatal adenovirus infections.[citation needed] Canine adenovirus 1 (CAdV-1) can lead to death in puppies, ...
Even where an Agamid shows no signs of infection, many are believed to be sub-clinically infected, or carriers of the virus. ... Agamid adenovirus (Agamid AdV1), also called Bearded dragon adenovirus 1, is a type of virus in the Adenoviridae family. The ... Kim, Dae Young; Mitchell, Mark A; Bauer, Rudy W; Poston, Rob; Cho, Doo-Youn (2016). "An Outbreak of Adenoviral Infection in ... It is probable that there is a relationship between dose of infection and clinical disease. Coinfections with other agents such ...
Unsurprisingly, sialic acids also play an important role in several human viral infections. The influenza viruses have ... Many viruses such as the Ad26 serotype of adenoviruses (Adenoviridae), rotaviruses (Reoviridae) and influenza viruses ( ...
Helminthiasis (worm infection), Ascariasis, and enterobiasis (pinworm infection) are few that are caused by various parasitic ... Pathogenic viruses are mainly those of the families of: Adenoviridae, Picornaviridae, Herpesviridae, Hepadnaviridae, ... 2014). Immune Response to Parasitic Infections. Immune Response to Parasitic Infections. Vol. 2. Bentham Science Publishers. ... or yeast infections. Most antibiotics that function on bacterial pathogens cannot be used to treat fungal infections because ...
A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus ... Adenoviridae, Papillomaviridae and Polyomaviridae) and two are enveloped (Herpesviridae and Poxviridae). All of the non- ... "Babies Born with CMV (Congenital CMV Infection)". Centers for Disease Control and Prevention. April 13, 2017. Retrieved June 17 ... Page 273 in: Lennette's Laboratory Diagnosis of Viral Infections (Fourth ed.). CRC Press. 2010. ISBN 978-1420084962. Murillo A ...
... (ICH) is an acute liver infection in dogs caused by Canine mastadenovirus A, formerly called Canine ... Carter, G.R.; Wise, D.J. (2006). "Adenoviridae". A Concise Review of Veterinary Virology. Retrieved 2006-06-10. Ettinger, ... Canine antibody diagnosis tests (Articles with 'species' microformats, Dog diseases, Animal viral diseases, Adenoviridae). ... CAV-2 is one of the causes of respiratory infections in dogs, but it is similar enough to CAV-1 that vaccine for one creates ...
In 2017, the ChAdOx1 vector was used in a trial for a vaccine candidate against human malaria infection. The researchers ... It has been demonstrated that the adenoviridae vector ChAdOx1 can be used to make vaccinations that are protective against ... For example, a vaccine for influenza infection was designed using the vector expressing influenza antigens, nucleoprotein (NP ...
The symptoms of CAP are the result of lung infection by microorganisms and the response of the immune system to the infection. ... and adenoviridae, mumps and enterovirus can also cause pneumonia. Another cause of neonatal CAP is Chlamydia trachomatis, which ... Viral infections weaken the immune system, making the body more susceptible to bacterial infection, including bacterial ... A life-threatening reaction to infection. A common cause of sepsis is bacterial pneumonia, frequently the result of infection ...
Symptoms of infection last for 1-2 days and include: Anorexia Dehydration Diarrhea Enteritis, the inflammation of the small ... Adenoviridae, Bird diseases, Falcons). ... Cross-species brooding of eggs increases the risk of infection ... Dean, J.; Latimer, K. S.; Oaks, J. L.; Schrenzel, M.; Redig, P. T.; Wünschmann, A. (2006). "Falcon adenovirus infection in ... The primary way to stop transmission is to separate sick falcons from uninfected ones susceptible to infection. As Falcon ...
Healthcare-associated gastrointestinal infections". In McNeil, J. Chase; Campbell, Judith R.; Crews, Jonathan D. (eds.). ... Human adenovirus 41 belongs to the Adenoviridae family, and along with human adenovirus 40, is a member of species human ... Healthcare-Associated Infections in Children: A Guide to Prevention and Management. Springer. p. 202. ISBN 978-3-319-98121-5. " ... "A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection". New England Journal of Medicine. 387 (7): 620- ...
It then injects its DNA or RNA into the host to initiate infection. In animal cells these viruses get into the cell through the ... An example of a family within this classification is the Adenoviridae. There is only one well-studied example in which a class ... Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must ... The Effects of Viral Infections and Viral Insulins on Host Metabolism". Annual Review of Virology. 8 (1): 373-391. doi:10.1146/ ...
It may appear similar to herpes simplex type I, acanthamoeba, and fungal infection. Adequate infection control measures should ... Adenoviridae, Eye diseases). ... ear infection, vomiting and diarrhea. It is commonly caused by ... A type of adenoviral keratoconjunctivitis in very young children can present with a high fever, sore throat, ear infection, ... Topical interferon might be effective as a prophylaxis of infection. Topical interferon is currently not commercially available ...
White, E; Cuconati, A (2002). "Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection". Genes & ... Proteins, Adenoviridae). ...
This method can be used on plants that are not susceptible to Agrobacterium infection and also allows transformation of plant ... DNA-based viral vectors include Adenoviridae, adeno-associated virus and herpes simplex virus. Several of the methods used to ...
The significance of the discovery lies in the fact that adenovirus infections have always been thought to be species-specific, ... Adenoviridae, All stub articles, Respiratory disease stubs). ...
"State calls for infection control plans following child deaths at nursing facility". NJTV News. NJTV News. June 6, 2019. "11th ... 2018 disasters in the United States, 2018 disease outbreaks, Adenoviridae, Disease outbreaks in the United States). ... Medicare inspections of the facility in 2016 and 2017 had also found "infection control issues." On October 24, 2018, a ... "establish and maintain an infection prevention and control program." Six employees were observed inadequately washing their ...
Other infections can be persistent, during which progeny viruses are continually produced at a low rate without causing cell ... is related to bacterial virus families Tectiviridae and Corticoviridae and many eukaryotic virus families such as Adenoviridae ... Archaeal virus infections can be virulent, temperate, or persistent. Virulent viruses replicate by producing progeny in the ... The high prevalence of chronic viral infections in archaea may act as a form of inter-virus competition, preventing an archaeon ...
An adenovirus vaccine is a vaccine against adenovirus infection. It was used by the United States military from 1971 to 1999, ... Adenoviridae, Vaccines). ...
It's been suggested that CAR-SIV resides in the insulin secreting granules and might be involved in the virus infection of ... Adenoviridae). ... suggesting that enteroviral infection may worsen the outcome of ... Patients exhibiting sudden death from acute myocardial infarction had a higher proportion of active coxsackie B virus infection ... "Active Coxsackieviral B infection is associated with disruption of dystrophin in endomyocardial tissue of patients who died ...
All articles with unsourced statements, Articles with unsourced statements from October 2022, Adenoviridae, Genomics, Animal ... and in suppression of the host response to infection. The L1-L5 transcription units are transcribed later in the viral ...
CAR is necessary for adenovirus infection. Although expressed widely in epithelial cells, CAR expression in tumours is ... Adenoviridae, Virotherapy, Biotechnology). ... required for transformation of rodent cells by viral infection ... "Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA ... extremely variable, leading to resistance to Ad5 infection. Retargeting of Ad5 from CAR, to another receptor that is ...
AD-36 infection can induce cellular differentiation of 3T3-L1 preadipocytes and stem cells derived from human adipose tissue. ... Adenoviridae, Medical conditions related to obesity). ... of the study participants had contracted Ad-36 viral infection ... has long been recognized as a cause of respiratory and eye infections in humans. It was first shown to be associated with ...
After viral infection, they stimulate expression of other viral genes and can either enhance or repress expression of cellular ... Adenoviridae). ... Almost an hour after viral infection, the virus undergoes ...
The Janssen COVID‑19 vaccine is used to provide protection against infection by the SARS-CoV-2 virus in order to prevent COVID‑ ... Adenoviridae, Clinical trials, American COVID-19 vaccines, Janssen Pharmaceutica, Johnson & Johnson brands, Products introduced ... July 2021). "Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection". ...
Learn more about viral infections and their symptoms. ... Viruses cause familiar infections such as the common cold, but ... ClinicalTrials.gov: Adenoviridae Infections (National Institutes of Health) * ClinicalTrials.gov: Coxsackievirus Infections ( ... Coxsackievirus Infections (For Parents) (Nemours Foundation) Also in Spanish * Enterovirus Infections (For Parents) (Nemours ... Antibiotics do not work for viral infections.. Can viral infections be prevented?. Vaccines can help prevent you from getting ...
Learn more about viral infections and their symptoms. ... Viruses cause familiar infections such as the common cold, but ... ClinicalTrials.gov: Adenoviridae Infections (National Institutes of Health) * ClinicalTrials.gov: Coxsackievirus Infections ( ... Coxsackievirus Infections (For Parents) (Nemours Foundation) Also in Spanish * Enterovirus Infections (For Parents) (Nemours ... Antibiotics do not work for viral infections.. Can viral infections be prevented?. Vaccines can help prevent you from getting ...
Categories: Adenoviridae Infections Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Adenoviridae Infections/metabolism; Adenoviridae Infections/pathology; Adenoviridae Infections/virology; Adenoviridae/genetics ... Papillomavirus Infections/metabolism; Papillomavirus Infections/pathology; Papillomavirus Infections/virology; Polymerase Chain ...
We describe a case of fatal adenovirus infection … ... Adenoviridae Infections / etiology* Actions. * Search in PubMed ... Gu J, Su QQ, Zuo TT, Chen YB. Gu J, et al. Infection. 2021 Feb;49(1):1-13. doi: 10.1007/s15010-020-01484-7. Epub 2020 Jul 27. ... Disseminated adenovirus infection in cancer patients presenting with focal pulmonary consolidation. Lee YJ, Palomino-Guilen P, ... Fatal adenovirus infection during alemtuzumab (anti-CD52 monoclonal antibody) treatment of a patient with fludarabine- ...
In our cohort, brincidofovir has shown promise in treatment of adenoviral infection. However, randomized controlled studies are ... Disseminated adenovirus infection is uncommon in adult transplant patients and uncertainties remain surrounding effective ... Adenoviridae Infections / drug therapy* Actions. * Search in PubMed * Search in MeSH * Add to Search ... Transplant details and data on timing of diagnosis, course of infection, viral co-infection and treatment were collected. ...
ADENOVIRIDAE INFECT. Entry Term(s). Adenovirus Infections Infections, Adenoviridae Infections, Adenovirus NLM Classification # ... Infections [C01] * Virus Diseases [C01.925] * DNA Virus Infections [C01.925.256] * Adenoviridae Infections [C01.925.256.076] * ... use ADENOVIRIDAE INFECTIONS to search ADENOVIRUS INFECTIONS 1966-93. History Note. 94; was ADENOVIRUS INFECTIONS 1963-93. Date ... Adenoviridae Infections Preferred Concept UI. M0000404. Scope Note. Virus diseases caused by the ADENOVIRIDAE.. Terms. ...
DNA Virus Infections [C02.256]. *Adenoviridae Infections [C02.256.076]. *Adenovirus Infections, Human [C02.256.076.045] ... "Adenovirus Infections, Human" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Neonatal adenovirus infection: four patients and review of the literature. Pediatrics. 1991 Jun; 87(6):890-6. ... This graph shows the total number of publications written about "Adenovirus Infections, Human" by people in this website by ...
60 genotypes are known to cause human infection (1). Clinical manifestations associated with HAdV infection include fever, ... Human adenoviruses (HAdVs) are nonenveloped, double-stranded DNA viruses in the family Adenoviridae; seven species (A-G) and , ... Kandel R, Srinivasan A, DAgata EM, Lu X, Erdman D, Jhung M. Outbreak of adenovirus type 4 infection in a long-term care ... Lion T. Adenovirus infections in immunocompetent and immunocompromised patients. Clin Microbiol Rev 2014;27:441-62. CrossRef ...
Adenoviridae Infection Adenovirus Infection Adenovirus Infections Infection, Adenoviridae Infection, Adenovirus Infections, ... Adenoviridae Infection. Adenovirus Infection. Adenovirus Infections. Infection, Adenoviridae. Infection, Adenovirus. Infections ... 94; was ADENOVIRUS INFECTIONS 1963-93. Online Note:. use ADENOVIRIDAE INFECTIONS to search ADENOVIRUS INFECTIONS 1966-93. ... Adenoviridae Infections - Preferred Concept UI. M0000404. Scope note. Virus diseases caused by the ADENOVIRIDAE. ...
ADENOVIRIDAE INFECT. Entry Term(s). Adenovirus Infections Infections, Adenoviridae Infections, Adenovirus NLM Classification # ... Infections [C01] * Virus Diseases [C01.925] * DNA Virus Infections [C01.925.256] * Adenoviridae Infections [C01.925.256.076] * ... use ADENOVIRIDAE INFECTIONS to search ADENOVIRUS INFECTIONS 1966-93. History Note. 94; was ADENOVIRUS INFECTIONS 1963-93. Date ... Adenoviridae Infections Preferred Concept UI. M0000404. Scope Note. Virus diseases caused by the ADENOVIRIDAE.. Terms. ...
Adenoviridae Infections (Phase 1) Anemia (Phase 4) Anemia, Iron-Deficiency (Phase 4) ...
Adenoviridae Infections Medicine & Life Sciences 36% * Genes Medicine & Life Sciences 32% * Tumor Suppressor Genes Medicine & ... The infection efficiency of the adenovirus vector and the expression level of REIC/Dkk-3 in the resistant clones were similar ... The infection efficiency of the adenovirus vector and the expression level of REIC/Dkk-3 in the resistant clones were similar ... The infection efficiency of the adenovirus vector and the expression level of REIC/Dkk-3 in the resistant clones were similar ...
AN - infection: coord IM with ADENOVIRIDAE INFECTIONS (IM) HN - 2002 BX - Porcine Adenoviruses MH - Adhatoda UI - D027902 MN - ... AN - infection = POLYOMAVIRUS INFECTIONS + TUMOR VIRUS INFECTIONS HN - 2002 MH - Polyomavirus Infections UI - D027601 MN - ... AN - infection: coord IM with ADENOVIRIDAE INFECTIONS (IM) HN - 2002 MH - Adenoviruses, Porcine UI - D025662 MN - B4.280.30.500 ... AN - infection: coord IM with ADENOVIRIDAE INFECTIONS (IM) HN - 2002; for FOWL ADENOVIRUS 1 use AVIADENOVIRUS 1994-2001; for ...
... infection or reduce post-infection viremia (STEP trial, HVTN 502/Merck 023) and Phambili (HVTN 503)). The vaccine was composed ... Applications should focus on four vaccine viral vector platforms developed from Adenoviridae, Poxviridae, Herpesviridae, or ... This increase in activated target cells at mucosal sites could result in increased susceptibility to HIV infection following ... Several hypotheses have been proposed for the increased susceptibility to infection after vaccination of Ad5 seropositive ...
Infecções por Adenoviridae; COVID-19; Hepatite; Humanos; Criança; Dependovirus/genética; Pandemias; Águas Residuárias; ... An association with adeno-associated virus type 2 (AAV2) infection, a human parvovirus, prompted us to investigate the ... Infecções por Adenoviridae / COVID-19 / Hepatite Tipo de estudo: Fatores de risco Limite: Criança / Humanos Idioma: Inglês ... Infecções por Adenoviridae / COVID-19 / Hepatite Tipo de estudo: Fatores de risco Limite: Criança / Humanos Idioma: Inglês ...
MacLachlan N J & Dubovi E J (2011) Adenoviridae. In: Fenners Veterinary Virology. 4th edn. Academic Press, UK. pp 203-212. ... Reddick R A & Lefkowitz S S (1969) In vitro immune responses of rabbits with persistent adenovirus type 5 infection. J Immunol ... Print off the factsheet on Adenovirus infection to give to your clients. Presenting signs. *Rabbits present with profuse ... Adenovirus infection is rarely reported as a clinical problem in the rabbit. ...
Adenoviridae Medicine & Life Sciences 9% * Respiratory Tract Infections Medicine & Life Sciences 8% ... Respiratory syncytial virus (RSV) is a major cause of lower respiratory infection in young children and the elderly. Studies of ... N2 - Respiratory syncytial virus (RSV) is a major cause of lower respiratory infection in young children and the elderly. ... AB - Respiratory syncytial virus (RSV) is a major cause of lower respiratory infection in young children and the elderly. ...
It is a member of the family Adenoviridae, which includes common cold and flu viruses. ADENOVIRUS can cause serious infection ... Inflammation is the bodys natural response to injury or infection. It helps rid the body of toxins and cells that have been ... Other causes can include: food allergies, infection with the rotavirus (a virus that can cause severe diarrhea), or travel to ... There is no specific treatment available for AUDIVAX infections other than monitoring and supportive care. ...
Adenoviridae QW 165.5.A3 Adenoviridae Infections WC 500 Adenovirus Infections See Adenoviridae Infections ...
ADENOVIRIDAE INFECTIONS (2) * ADENOVIRUS E1 A PROTEINS (1) * ADENOVIRUS E1 B BPROTEINS (1) ... Pathways of ceramide accumulation in response to adenoviral infection - by Maher Al Ayyoubi  ...
RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and ... HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE ... Enterovirus InfectionsHand, Foot and Mouth DiseaseEchovirus InfectionsMeningitis, AsepticHerpanginaMeningitis, Viral ...
Acute Disease Adenoviridae Infections Child Child, Preschool Hepatitis Infant *. Document Type: Webpage ...
Adenoviridae Adenoviridae Infections Adenovirus E1 Proteins Adenovirus E1A Proteins Adenovirus E1B Proteins Adenovirus E2 ... Astroviridae Infections Asymmetric Cell Division Asymptomatic Diseases Asymptomatic Infections AT Rich Sequence AT-Hook Motifs ... Central Nervous System Infections Central Nervous System Neoplasms Central Nervous System Parasitic Infections Central Nervous ... Bacterial Infections Bacterial Infections and Mycoses Bacterial Load Bacterial Outer Membrane Proteins Bacterial Physiological ...
IMPORTANCE: HCV infection is a major health problem. Despite the availability of new directly acting antiviral agents for ... keywords = "Adenoviridae, Adjuvants, Immunologic, Animals, Antibodies, Neutralizing, Female, Genetic Vectors, Guinea Pigs, ... UNLABELLED: Despite the recent progress in the development of new antiviral agents, hepatitis C virus (HCV) infection remains a ... N2 - UNLABELLED: Despite the recent progress in the development of new antiviral agents, hepatitis C virus (HCV) infection ...
Adenoviridae 20% * Health Surveys 20% * Human Influenza 19% * Laboratory Infection 15% * Infection 9% ...
Symptoms of rotavirus infection are usually vomiting, watery diarrhoea and abdominal pain. The virus is transmitted by the ... Adenoviruses belong to the Adenoviridae family of non-enveloped icosahedral double-stranded (dsDNA) viruses. One differentiates ... In the US, viral infections cause approximately 30.8 million cases of gastroenteritis, yearly. The most important pathogens ... 70,000 hospitalisations and 800 deaths are caused by norovirus infections each year.. Rotaviruses belong to the Reoviridae ...
Opportunistic Infections 32% * Viral Immunoregulatory Genes and Hepatocyte Transplants. Roy-Chowdhury, J. ...
  • Human adenoviruses (HAdVs) can cause a wide spectrum of clinical illness, ranging from asymptomatic infections to severe illnesses and death. (cdc.gov)
  • Adenoviruses belong to the Adenoviridae family of non-enveloped icosahedral double-stranded (dsDNA) viruses. (r-biopharm.com)
  • We describe a case of fatal adenovirus infection in a heavily pretreated patient with fludarabine-refractory B-CLL receiving alemtuzumab therapy, drawing attention to the fact that also viruses other than cytomegalovirus (CMV) and herpes simplex (HSV) need to be considered in B-CLL patients with fever of unknown origin while on alemtuzumab treatment. (nih.gov)
  • Applications should focus on four vaccine viral vector platforms developed from Adenoviridae, Poxviridae, Herpesviridae, or Adeno-associated viruses in humans or non-human primates (NHPs). (nih.gov)
  • It is a member of the family Adenoviridae, which includes common cold and flu viruses. (healthlinepalace.com)
  • Secondary bacterial infections (E. coli) or coinfection with immunosuppressive viruses such as Marek's disease virus, infectious bursal disease virus (IBDV) [33, 47, 48], may worsen the outcomes of IBV infection. (datexis.com)
  • Clinical manifestations associated with HAdV infection include fever, acute respiratory illness, gastroenteritis, and conjunctivitis. (cdc.gov)
  • Respiratory syncytial virus (RSV) is a major cause of lower respiratory infection in young children and the elderly. (ewha.ac.kr)
  • ORT spreads horizontally through aerosols and drinking water with longer survival rates at lower temperature, which also explains its dissemination during winter months and concurrent infection with other respiratory diseases common during winter season. (datexis.com)
  • Bacterial vs. Viral Infections: How Do They Differ? (nih.gov)
  • The skin tissue biopsy not treated soon enough ears in atopic dogs or two with good to other parts of wound packing following which the affected area is us will recall those secondary intention resulting in high bacterial infection. (websitesdemos.xyz)
  • The articles discussed in this review recapitulate the adverse impacts of co/secondary viral and/or bacterial infections on AIVs infection in poultry, as well as the synergy between different pathogens (Table 1). (datexis.com)
  • Moreover, this review provides important insights into the variation in the rates of severe morbidity and/or mortality that subsequently occur in the case of co-infection or pre-infection with another bacterial or viral pathogen. (datexis.com)
  • It has also been documented that AI-related bacterial and viral infections overall may account for up to a remarkable percent of reported cases under field conditions in different countries. (datexis.com)
  • 2 Department of Infectious Disease, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas. (nih.gov)
  • For more serious infections, is not considered infectious implant Preventive measures include make your best guess as to what type the prescription. (websitesdemos.xyz)
  • The purpose of this Funding Opportunity Announcement (FOA) is to support increased understanding of the biology and immunology of natural viral infections and HIV vaccine vectors. (nih.gov)
  • Orthohantaviruses typically cause chronic asymptomatic infection in rodents . (wikipedia.org)
  • Adenovirus infection is rarely reported as a clinical problem in the rabbit. (vetlexicon.com)
  • If combined with the adenovirus vaccine targeting the HCV NS antigens now under clinical testing, this new vaccine might lead to a stronger and broader immune response and to a more effective vaccine to prevent HCV infection. (birmingham.ac.uk)
  • Virus diseases caused by the ADENOVIRIDAE . (nih.gov)
  • Inflammation of brain parenchymal tissue as a result of viral infection. (lookformedical.com)
  • About 10 to 15 of the Adenoviridae family that and has practically no A strep by RADT even if you start up to 80 have. (websitesdemos.xyz)
  • Moreover, detection of viral RNA packaged in CsCl purified human adenovirus (HAdV) -5 virions indicates that the viral RNA packaging might be a common phenomenon in members of Adenoviridae family. (biomedcentral.com)
  • Antibiotics do not work for viral infections. (nih.gov)
  • Physicians prescribe antibiotics (usually infection is not contagious no longer in and allergies. (websitesdemos.xyz)
  • Antibiotics will be most 9 months or older and has reoccurring thrush antifungal properties, may rid to your needs rather Infection?Throat infection is the into your stomach and with the immune system. (websitesdemos.xyz)
  • Symptoms of rotavirus infection are usually vomiting, watery diarrhoea and abdominal pain. (r-biopharm.com)
  • Goals of the research include the development of improved safety models to assess the potential vaccine-related effects such as increased HIV infection rates due to immune activated vector-specific HIV target cells (e.g. (nih.gov)
  • Thus, our results show that IL-2 has potential to be used as a vaccine adjuvant against RSV infection. (ewha.ac.kr)
  • UNLABELLED: Despite the recent progress in the development of new antiviral agents, hepatitis C virus (HCV) infection remains a major global health problem, and there is a need for a preventive vaccine. (birmingham.ac.uk)
  • Despite the availability of new directly acting antiviral agents for treating chronic infection, an affordable preventive vaccine provides the best long-term goal for controlling the global epidemic. (birmingham.ac.uk)
  • Furthermore, experimental preinfection with ORT and secondary infection with LPAIV H9N2 (A/chicken/Shandong/2011 (H9N2)) three days later induced the highest mortality rate with development of severe pneumonia and airsacculitis. (datexis.com)
  • On the other hand, a lower mortality was induced by coinfection and pre-infection with LPAIV H9N2 than in association with a secondary infection of ORT. (datexis.com)
  • Altogether, ORT as a preinfection, concurrent infection, or secondary infection is able to exacerbate the virulence of LPAIV H9N2 as compared to infection with LPAIV H9N2 alone. (datexis.com)
  • However, pre-infection with ORT and secondary infection with H9N2 induces a higher mortality rate with unique histopathological lesions represented by severe pulmonary fibrosis. (datexis.com)
  • There are antiviral medicines to treat some viral infections. (nih.gov)
  • Through droplets and particles that are breathed out by someone who has the infection. (nih.gov)
  • In the US, viral infections cause approximately 30.8 million cases of gastroenteritis, yearly. (r-biopharm.com)
  • In the US, it is estimated, that more than 21 million cases of acute gastroenteritis, 70,000 hospitalisations and 800 deaths are caused by norovirus infections each year. (r-biopharm.com)
  • For most viral infections, treatments can only help with symptoms while you wait for your immune system to fight off the virus. (nih.gov)
  • The infection efficiency of the adenovirus vector and the expression level of REIC/Dkk-3 in the resistant clones were similar to those in the parental PC3 cells. (elsevierpure.com)
  • In order to obtain empty/intermediate and mature capsids, VIDO R1 cells were infected with wt PAdV-3 or mutant Pav3-PL1 at a multiplicity of infection (MOI) of 10 plaque forming units (PFUs). (biomedcentral.com)
  • At 48 h post infection, the infected cells were collected and freezed-thawed three times. (biomedcentral.com)
  • Efficiency of Ad infection in the cells was determined by the use of an Ad construct expressing the green fluorescence protein (GFP) marker in place of the E1A gene (Ad5/3-CXCR4-GFP) and quantified by flow cytometry. (unthsc.edu)
  • Adenovirus infection in immunocompromised patients contributes to significant morbidity and mortality, especially after allogeneic hematopoietic cell transplantation (HCT). (nih.gov)
  • There is no specific treatment available for AUDIVAX infections other than monitoring and supportive care. (healthlinepalace.com)
  • Treatment for both is primarily supportive as there is no specific treatment for hantavirus infections. (wikipedia.org)
  • Postpandemic rebound of adeno-associated virus type 2 (AAV2) infections temporally associated with an outbreak of unexplained severe acute hepatitis in children in the United Kingdom. (bvsalud.org)
  • An association with adeno-associated virus type 2 (AAV2) infection , a human parvovirus , prompted us to investigate the epidemiology of AAV in the United Kingdom . (bvsalud.org)
  • Vaccines with both inactivated and live attenuated virus have proven effective in immunizing against the infection. (lookformedical.com)
  • A heterogeneous group of infections produced by coxsackieviruses, including HERPANGINA , aseptic meningitis ( MENINGITIS, ASEPTIC ), a common-cold-like syndrome, a non-paralytic poliomyelitis-like syndrome, epidemic pleurodynia (PLEURODYNIA, EPIDEMIC) and a serious MYOCARDITIS . (lookformedical.com)
  • 10.1186/1742-4682-7-1 cases, animal-to-animal transmission illness if infection occurs. (cdc.gov)