Adenoviral gene transfer of the human V2 vasopressin receptor improves contractile force of rat cardiomyocytes. (1/761)BACKGROUND: In congestive heart failure, high systemic levels of the hormone arginine vasopressin (AVP) result in vasoconstriction and reduced cardiac contractility. These effects are mediated by the V1 vasopressin receptor (V1R) coupled to phospholipase C beta-isoforms. The V2 vasopressin receptor (V2R), which promotes activation of the Gs/adenylyl cyclase system, is physiologically expressed in the kidney but not in the myocardium. Expression of a recombinant V2R (rV2R) in the myocardium could result in a positive inotropic effect via the endogenous high concentrations of AVP in heart failure. METHODS AND RESULTS: A recombinant adenovirus encoding the human V2R (Ad-V2R) was tested for its ability to modulate the cardiac Gs/adenylyl cyclase system and to potentiate contractile force in rat ventricular cardiomyocytes and in H9c2 cardiomyoblasts. Ad-V2R infection resulted in a virus concentration-dependent expression of the transgene and led to a marked increase in cAMP formation in rV2R-expressing cardiomyocytes after exposure to AVP. Single-cell shortening measurements showed a significant agonist-induced contraction amplitude enhancement, which was blocked by the V2R antagonist, SR 121463A. Pretreatment of Ad-V2R-infected cardiomyocytes with AVP led to desensitization of the rV2R after short-term agonist exposure but did not lead to further loss of receptor function or density after long-term agonist incubation, thus demonstrating resistance of the rV2R to downregulation. CONCLUSIONS: Adenoviral gene transfer of the V2R in cardiomyocytes can modulate the endogenous adenylyl cyclase-signal transduction cascade and can potentiate contraction amplitude in cardiomyocytes. Heterologous expression of cAMP-forming receptors in the myocardium could lead to novel strategies in congestive heart failure by bypassing the desensitized beta-adrenergic receptor signaling. (+info)
A single amino acid in the adenovirus type 37 fiber confers binding to human conjunctival cells. (2/761)A 46-kDa receptor, coxsackievirus-adenovirus (Ad) receptor (CAR), mediates cell attachment of a number of different Ad serotypes; however, not all Ad serotypes utilize this receptor for infection. Moreover, the precise amino acid sequences in the Ad fiber protein that mediate cell attachment have yet to be identified. We investigated the interaction of subgroup D Ads with human ocular cells. Ad serotype 37 (Ad37), a virus associated with epidemic keratoconjunctivitis, but not a closely related virus serotype, Ad19p, exhibited preferential binding to and infection of human conjunctival cells. A single amino acid substitution in the Ad19p fiber distal domain (knob), Glu240 to Lys, conferred binding to conjunctival cells, while the reverse substitution in the Ad37 fiber abrogated cell binding. These findings provide new information on the fiber sequences that regulate Ad host cell tropism. (+info)
Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction. (3/761)BACKGROUND: The use of molecular biological techniques has demonstrated the importance of enteroviral infection of the myocardium in the pathogenesis of myocarditis and dilated cardiomyopathy in adults and adenovirus and enterovirus infection in children. The aim of this study was to determine the frequency of adenoviral infection of the myocardium of adults with impaired left ventricular function of unknown origin. METHODS AND RESULTS: Nested polymerase chain reaction (nPCR) was used to determine the frequency of detection of adenoviral DNA and enteroviral RNA in myocardial tissue samples from 94 adult patients with idiopathic left ventricular dysfunction and 14 control patients. Histological and immunohistological analyses were performed to detect myocardial inflammation. Adenoviral genomic DNA was detected by nPCR in 12 of the 94 patients with left ventricular dysfunction (in each case, adenovirus type 2), whereas enteroviral RNA was detected in another 12 patients. All control samples were negative for both viruses. In all patients, active myocarditis was excluded according to the Dallas criteria. However, there was significantly decreased CD2, CD3, and CD45RO T lymphocyte counts in the adenovirus-positive group compared with the adenovirus-negative group (P<0.05), whereas no differences were associated with enterovirus infection. CONCLUSIONS: Although enteroviruses are an important causative agent in the pathogenesis of myocarditis and dilated cardiomyopathy, this study shows that adenovirus infection is also important in the pathogenesis of left ventricular failure in adults. However, the pathogenetic basis of disease associated with adenovirus infection may be different than that after infection with other agents, particularly with respect to activation of the host immune response. (+info)
Adenovirus infection after pediatric bone marrow transplantation. (4/761)Retrospective analysis of 206 patients undergoing 215 consecutive bone marrow transplants (BMT) at St Jude Children's Research Hospital between November 1990 and December 1994 identified 6% (seven male, six female) with adenovirus infection. The affected patients had a median age of 7.9 years (range 3-24 years) at time of transplantation. Although transplants were performed for hematologic malignancies, solid tumors or nonmalignant conditions, only patients with hematologic malignancies had adenoviral infections. Adenovirus was first detected at a median of 54 days (range -4 to +333) after BMT. Adenovirus developed in eight of 69 (11.6%) patients receiving grafts from matched unrelated or mismatched related donors, in four of 52 (7.7%) receiving grafts from HLA-matched siblings, and in one of 93 (1.1%) receiving autografts. The most common manifestation of adenovirus infection was hemorrhagic cystitis, followed by gastroenteritis, pneumonitis and liver failure. The incidence of adenovirus infection in pediatric BMT patients at our institution is similar to that reported in adult patients. Using univariate analysis, use of total body irradiation and type of bone marrow graft were significant risk factors for adenovirus infection. Only use of total body irradiation remained as a factor on multiple logistic regression analysis. (+info)
Lesions and transmission of experimental adenovirus hemorrhagic disease in black-tailed deer fawns. (5/761)Adenovirus infection was the cause of an epizootic of hemorrhagic disease that is believed to have killed thousands of mule deer (Odocoileus hemionus) in California during the latter half of 1993. A systemic vasculitis with pulmonary edema and hemorrhagic enteropathy or a localized vasculitis associated with necrotizing stomatitis/pharyngitis/glossitis or osteomyelitis of the jaw were common necropsy findings in animals that died during this epizootic. To study transmission of adenovirus infection in deer and susceptibility of black-tailed deer (Odocoileus hemionus columbianus) fawns to adenovirus infection, six 3-6-month-old black-tailed fawns were divided into two treatment groups. One group was inoculated intravenously and the other group was inoculated through the mucous membranes of the eyes, nose and mouth with purified adenovirus. Each treatment group also included two additional fawns (four total) that were not inoculated but were exposed to inoculated animals (contact animals). One fawn served as a negative control. Between 4 and 16 days postinoculation, 8/10 fawns developed systemic or localized infection with lesions identical to lesions seen in animals with natural disease that died during the epizootic. Transmission was by direct contact, and the route of inoculation did not affect the incubation period or the distribution of the virus (systemic or the localized infection). Immunohistochemical analysis using polyclonal antiserum against bovine adenovirus type 5 demonstrated staining in endothelial cells of vessels in numerous tissues in animals with systemic infection and endothelial staining only in vessels subtending necrotic foci in the upper alimentary tract in animals with the localized form of the disease. All inoculated or exposed animals had staining in the tonsillar epithelium. Transmission electron microscopic examination of lung and ileum from two fawns with pulmonary edema and hemorrhagic enteropathy demonstrated endothelial necrosis and adenovirus virions in endothelial cell nuclei. Adenovirus was reisolated in black-tailed deer pulmonary artery endothelial cells using lung homogenate of the first fawn that developed systemic adenovirus infection. Serum virus neutralization test results suggest that this deer adenovirus is a new serotype. (+info)
Gene transfer to human pancreatic endocrine cells using viral vectors. (6/761)We have studied the factors that influence the efficiency of infection of human fetal and adult pancreatic endocrine cells with adenovirus, murine retrovirus, and lentivirus vectors all expressing the green fluorescent protein (Ad-GFP, MLV-GFP, and Lenti-GFP, respectively). Adenoviral but not retroviral vectors efficiently infected intact pancreatic islets and fetal islet-like cell clusters (ICCs) in suspension. When islets and ICCs were plated in monolayer culture, infection efficiency with all three viral vectors increased. Ad-GFP infected 90-95% of the cells, whereas infection with MLV-GFP and Lenti-GFP increased only slightly. Both exposure to hepatocyte growth factor/scatter factor (HGF/SF) and dispersion of the cells by removal from the culture dish and replating had substantial positive effects on the efficiency of infection with retroviral vectors. Studies of virus entry and cell replication revealed that cell dispersion and stimulation by HGF/SF may be acting through both mechanisms to increase the efficiency of retrovirus-mediated gene transfer. Although HGF/SF and cell dispersion increased the efficiency of infection with MLV-GFP, only rare cells with weak staining for insulin were infected, whereas approximately 25% of beta-cells were infected with Lenti-GFP. We conclude that adenovirus is the most potent vector for ex vivo overexpression of foreign genes in adult endocrine pancreatic cells and is the best vector for applications where high-level but transient expression is desired. Under the optimal conditions of cell dispersion plus HGF/SF, infection with MLV and lentiviral vectors is reasonably efficient and stable, but only lentiviral vectors efficiently infect pancreatic beta-cells. (+info)
Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. (7/761)To understand the function of specific proteins in sensory hair cells, it is necessary to add or inactivate those proteins in a system where their physiological effects can be studied. Unfortunately, the usefulness of heterologous expression systems for the study of many hair cell proteins is limited by the inherent difficulty of reconstituting the hair cell's exquisite cytoarchitecture. Expression of exogenous proteins within hair cells themselves may provide an alternative approach. Because recombinant viruses were efficient vectors for gene delivery in other systems, we screened three viral vectors for their ability to express exogenous genes in hair cells of organotypic cultures from mouse auditory and vestibular organs. We observed no expression of the genes for beta-galactosidase or green fluorescent protein (GFP) with either herpes simplex virus or adeno-associated virus. On the other hand, we found robust expression of GFP in hair cells exposed to a recombinant, replication-deficient adenovirus that carried the gene for GFP driven by a cytomegalovirus promoter. Titers of 4 x 10(7) pfu/ml were sufficient for expression in 50% of the approximately 1,000 hair cells in the utricular epithelium; < 1% of the nonhair cells in the epithelium were GFP positive. Expression of GFP was evident as early as 12 h postinfection, was maximal at 4 days, and continued for at least 10 days. Over the first 36 h there was no evidence of toxicity. We recorded normal voltage-dependent and transduction currents from infected cells identified by GFP fluorescence. At longer times hair bundle integrity was compromised despite a cell body that appeared healthy. To assess the ability of adenovirus-mediated gene transfer to alter hair cell function we introduced the gene for the ion channel Kir2.1. We used an adenovirus vector encoding Kir2.1 fused to GFP under the control of an ecdysone promoter. Unlike the diffuse distribution within the cell body we observed with GFP, the ion channel-GFP fusion showed a pattern of fluorescence that was restricted to the cell membrane and a few extranuclear punctate regions. Patch-clamp recordings confirmed the expression of an inward rectifier with a conductance of 43 nS, over an order of magnitude larger than the endogenous inward rectifier. The zero-current potential in infected cells was shifted by -17 mV. These results demonstrate an efficient method for gene transfer into both vestibular and auditory hair cells in culture, which can be used to study the effects of gene products on hair cell function. (+info)
Tracheal aspirate as a substrate for polymerase chain reaction detection of viral genome in childhood pneumonia and myocarditis. (8/761)BACKGROUND: Infectious respiratory disorders are important causes of childhood morbidity and mortality. Viral causes are common and may lead to rapid deterioration, requiring mechanical ventilation; myocardial dysfunction may accompany respiratory decompensation. The etiologic viral diagnosis may be difficult with classic methods. The purpose of this study was to evaluate polymerase chain reaction (PCR) as a diagnostic method for identification of causative agents. METHODS AND RESULTS: PCR was used to amplify sequences of viruses known to cause childhood viral pneumonia and myocarditis. Oligonucleotide primers were designed to amplify specific sequences of DNA virus (adenovirus, cytomegalovirus, herpes simplex virus, and Epstein-Barr virus) and RNA virus (enterovirus, respiratory syncytial virus, influenza A, and influenza B) genomes. Tracheal aspirate samples were obtained from 32 intubated patients and nucleic acid extracted before PCR. PCR results were compared with results of culture, serology, and antigen detection methods when available. In cases of myocarditis (n=7), endomyocardial biopsy samples were analyzed by PCR and compared with tracheal aspirate studies. PCR amplification of viral genome occurred in 18 of 32 samples (56%), with 3 samples PCR positive for 2 viral genomes. Amplified viral sequences included RSV (n=3), enterovirus (n=5), cytomegalovirus (n=4), adenovirus (n=3), herpes simplex virus (n=2), Epstein-Barr virus (n=1), influenza A (n=2), and influenza B (n=1). All 7 cases of myocarditis amplified the same viral genome from heart as found by tracheal aspirate. CONCLUSIONS: PCR is a rapid and sensitive diagnostic tool in cases of viral pneumonia with or without myocarditis, and tracheal aspirate appears to be excellent for analysis. (+info)
Types of Adenoviridae Infections:
1. Respiratory adenovirus infection (bronchiolitis, pneumonia)
2. Gastroenteric adenovirus infection (gastroenteritis)
3. Eye adenovirus infection (conjunctivitis)
4. Skin adenovirus infection (keratoconjunctivitis)
5. Intestinal adenovirus infection (diarrhea, vomiting)
6. Adenovirus-associated hemorrhagic cystitis
7. Adenovirus-associated hypertrophic cardiomyopathy
8. Adenovirus-associated myocarditis
Symptoms of Adenoviridae Infections:
1. Respiratory symptoms (cough, fever, difficulty breathing)
2. Gastrointestinal symptoms (diarrhea, vomiting, abdominal pain)
3. Eye symptoms (redness, discharge, sensitivity to light)
4. Skin symptoms (rash, blisters, skin erosion)
5. Intestinal symptoms (abdominal cramps, fever, chills)
6. Cardiovascular symptoms (hypertension, tachycardia, myocarditis)
Diagnosis of Adenoviridae Infections:
1. Physical examination and medical history
2. Laboratory tests (rapid antigen detection, PCR, electron microscopy)
3. Imaging studies (chest X-ray, CT scan, MRI)
4. Biopsy (tissue or organ biopsy)
Treatment of Adenoviridae Infections:
1. Supportive care (fluids, oxygen therapy, pain management)
2. Antiviral medications (ribavirin, cidofovir)
3. Immune modulators (immunoglobulins, corticosteroids)
4. Surgical intervention (in severe cases of adenovirus-associated disease)
Prevention of Adenoviridae Infections:
1. Good hygiene practices (handwashing, surface cleaning)
2. Avoiding close contact with individuals who are infected
3. Properly storing and preparing food
4. Avoiding sharing of personal items (utensils, drinking glasses, towels)
5. Immunization (vaccination against adenovirus)
The incubation period for adenoviruses is typically between 3-7 days, but it can range from 1-2 weeks in some cases.
Adenoviruses are highly contagious and can be transmitted before symptoms appear and during the entire course of illness. The virus can be shed for several weeks after infection.
Individuals with weakened immune systems (children, elderly, those with chronic illnesses) are at a higher risk of developing severe adenovirus infections. Additionally, those who live in crowded or unsanitary conditions and those who engage in behaviors that compromise their immune system (smoking, excessive alcohol consumption) are also at a higher risk.
Adenovirus infections can lead to a variety of complications, including pneumonia, meningitis, encephalitis, and other respiratory, gastrointestinal, and eye infections. In severe cases, adenovirus infections can be fatal.
The recovery time for adenovirus infections varies depending on the severity of the infection and the individual's overall health. Mild cases of adenovirus may resolve within a few days to a week, while more severe cases may take several weeks to recover from. In some cases, hospitalization may be necessary for individuals with severe infections or those who experience complications.
There is no specific contraceptive measure that can prevent adenovirus infections. However, practicing good hygiene, such as frequent handwashing and avoiding close contact with people who are sick, can help reduce the risk of transmission.
Adenovirus infections during pregnancy are rare but can be severe. Pregnant women who develop adenovirus infections may experience complications such as preterm labor and low birth weight. It is essential for pregnant women to seek medical attention immediately if they suspect they have an adenovirus infection.
Adenovirus infections can be diagnosed through a variety of tests, including polymerase chain reaction (PCR), electron microscopy, and culture. A healthcare provider will typically perform a physical examination and take a medical history to determine the likelihood of an adenovirus infection.
There is no specific treatment for adenovirus infections, but symptoms can be managed with supportive care such as hydration, rest, and over-the-counter pain relievers. Antiviral medications may be prescribed in severe cases or for individuals with compromised immune systems.
Preventing the spread of adenovirus is essential, especially in high-risk populations such as young children and those with weakened immune systems. Practicing good hygiene, such as frequent handwashing and avoiding close contact with people who are sick, can help reduce the risk of transmission. Vaccines are also available for some types of adenovirus.
The prognosis for adenovirus infections is generally good, especially for mild cases. However, severe cases can lead to complications such as pneumonia, meningitis, and encephalitis, which can be life-threatening. In some cases, long-term health problems may persist after recovery from an adenovirus infection.
Adenovirus infections can lead to various complications, including:
1. Pneumonia: Adenovirus can cause pneumonia, which is an inflammation of the lungs that can lead to fever, chest pain, and difficulty breathing.
2. Meningitis: Adenovirus can cause meningitis, which is an inflammation of the membranes surrounding the brain and spinal cord. Symptoms include headache, stiff neck, and sensitivity to light.
3. Encephalitis: Adenovirus can cause encephalitis, which is an inflammation of the brain that can lead to confusion, seizures, and coma.
4. Gastrointestinal symptoms: Adenovirus can cause gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain.
5. Long-term health problems: In some cases, adenovirus infections can lead to long-term health problems such as asthma, allergies, and autoimmune disorders.
Adenovirus serotype 14
Infectious canine hepatitis
Falcon aviadenovirus A
Human adenovirus 41
Adenovirus E1B protein
Titi monkey adenovirus
2018 United States adenovirus outbreak
Coxsackievirus and adenovirus receptor
Adenovirus serotype 36
Adenovirus early region 1A
Janssen COVID-19 vaccine
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- We describe a case of fatal adenovirus infection in a heavily pretreated patient with fludarabine-refractory B-CLL receiving alemtuzumab therapy, drawing attention to the fact that also viruses other than cytomegalovirus (CMV) and herpes simplex (HSV) need to be considered in B-CLL patients with fever of unknown origin while on alemtuzumab treatment. (nih.gov)
- Applications should focus on four vaccine viral vector platforms developed from Adenoviridae, Poxviridae, Herpesviridae, or Adeno-associated viruses in humans or non-human primates (NHPs). (nih.gov)
- It is a member of the family Adenoviridae, which includes common cold and flu viruses. (healthlinepalace.com)
- Secondary bacterial infections (E. coli) or coinfection with immunosuppressive viruses such as Marek's disease virus, infectious bursal disease virus (IBDV) [33, 47, 48], may worsen the outcomes of IBV infection. (datexis.com)
- Clinical manifestations associated with HAdV infection include fever, acute respiratory illness, gastroenteritis, and conjunctivitis. (cdc.gov)
- Respiratory syncytial virus (RSV) is a major cause of lower respiratory infection in young children and the elderly. (ewha.ac.kr)
- ORT spreads horizontally through aerosols and drinking water with longer survival rates at lower temperature, which also explains its dissemination during winter months and concurrent infection with other respiratory diseases common during winter season. (datexis.com)
- Some infections in humans were reported. (harvard.edu)
- Bacterial vs. Viral Infections: How Do They Differ? (nih.gov)
- The skin tissue biopsy not treated soon enough ears in atopic dogs or two with good to other parts of wound packing following which the affected area is us will recall those secondary intention resulting in high bacterial infection. (websitesdemos.xyz)
- The articles discussed in this review recapitulate the adverse impacts of co/secondary viral and/or bacterial infections on AIVs infection in poultry, as well as the synergy between different pathogens (Table 1). (datexis.com)
- Moreover, this review provides important insights into the variation in the rates of severe morbidity and/or mortality that subsequently occur in the case of co-infection or pre-infection with another bacterial or viral pathogen. (datexis.com)
- It has also been documented that AI-related bacterial and viral infections overall may account for up to a remarkable percent of reported cases under field conditions in different countries. (datexis.com)
- 2 Department of Infectious Disease, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas. (nih.gov)
- For more serious infections, is not considered infectious implant Preventive measures include make your best guess as to what type the prescription. (websitesdemos.xyz)
- The purpose of this Funding Opportunity Announcement (FOA) is to support increased understanding of the biology and immunology of natural viral infections and HIV vaccine vectors. (nih.gov)
- Orthohantaviruses typically cause chronic asymptomatic infection in rodents . (wikipedia.org)
- Adenovirus infection is rarely reported as a clinical problem in the rabbit. (vetlexicon.com)
- If combined with the adenovirus vaccine targeting the HCV NS antigens now under clinical testing, this new vaccine might lead to a stronger and broader immune response and to a more effective vaccine to prevent HCV infection. (birmingham.ac.uk)
- Virus diseases caused by the ADENOVIRIDAE . (nih.gov)
- Inflammation of brain parenchymal tissue as a result of viral infection. (lookformedical.com)
- About 10 to 15 of the Adenoviridae family that and has practically no A strep by RADT even if you start up to 80 have. (websitesdemos.xyz)
- Moreover, detection of viral RNA packaged in CsCl purified human adenovirus (HAdV) -5 virions indicates that the viral RNA packaging might be a common phenomenon in members of Adenoviridae family. (biomedcentral.com)
- Antibiotics do not work for viral infections. (nih.gov)
- Physicians prescribe antibiotics (usually infection is not contagious no longer in and allergies. (websitesdemos.xyz)
- Antibiotics will be most 9 months or older and has reoccurring thrush antifungal properties, may rid to your needs rather Infection?Throat infection is the into your stomach and with the immune system. (websitesdemos.xyz)
- Symptoms of rotavirus infection are usually vomiting, watery diarrhoea and abdominal pain. (r-biopharm.com)
- Goals of the research include the development of improved safety models to assess the potential vaccine-related effects such as increased HIV infection rates due to immune activated vector-specific HIV target cells (e.g. (nih.gov)
- Thus, our results show that IL-2 has potential to be used as a vaccine adjuvant against RSV infection. (ewha.ac.kr)
- UNLABELLED: Despite the recent progress in the development of new antiviral agents, hepatitis C virus (HCV) infection remains a major global health problem, and there is a need for a preventive vaccine. (birmingham.ac.uk)
- Despite the availability of new directly acting antiviral agents for treating chronic infection, an affordable preventive vaccine provides the best long-term goal for controlling the global epidemic. (birmingham.ac.uk)
- Furthermore, experimental preinfection with ORT and secondary infection with LPAIV H9N2 (A/chicken/Shandong/2011 (H9N2)) three days later induced the highest mortality rate with development of severe pneumonia and airsacculitis. (datexis.com)
- On the other hand, a lower mortality was induced by coinfection and pre-infection with LPAIV H9N2 than in association with a secondary infection of ORT. (datexis.com)
- Altogether, ORT as a preinfection, concurrent infection, or secondary infection is able to exacerbate the virulence of LPAIV H9N2 as compared to infection with LPAIV H9N2 alone. (datexis.com)
- However, pre-infection with ORT and secondary infection with H9N2 induces a higher mortality rate with unique histopathological lesions represented by severe pulmonary fibrosis. (datexis.com)
- Journal of Microbiology, Immunology and Infection. (elsevierpure.com)
- The infection is mostly is conjunctivitis in children. (websitesdemos.xyz)
- There are antiviral medicines to treat some viral infections. (nih.gov)
- Through droplets and particles that are breathed out by someone who has the infection. (nih.gov)
- For most viral infections, treatments can only help with symptoms while you wait for your immune system to fight off the virus. (nih.gov)
- The infection efficiency of the adenovirus vector and the expression level of REIC/Dkk-3 in the resistant clones were similar to those in the parental PC3 cells. (elsevierpure.com)
- In order to obtain empty/intermediate and mature capsids, VIDO R1 cells were infected with wt PAdV-3 or mutant Pav3-PL1 at a multiplicity of infection (MOI) of 10 plaque forming units (PFUs). (biomedcentral.com)
- At 48 h post infection, the infected cells were collected and freezed-thawed three times. (biomedcentral.com)
- Efficiency of Ad infection in the cells was determined by the use of an Ad construct expressing the green fluorescence protein (GFP) marker in place of the E1A gene (Ad5/3-CXCR4-GFP) and quantified by flow cytometry. (unthsc.edu)
- Adenovirus infection in immunocompromised patients contributes to significant morbidity and mortality, especially after allogeneic hematopoietic cell transplantation (HCT). (nih.gov)
- Postpandemic rebound of adeno-associated virus type 2 (AAV2) infections temporally associated with an outbreak of unexplained severe acute hepatitis in children in the United Kingdom. (bvsalud.org)
- An association with adeno-associated virus type 2 (AAV2) infection , a human parvovirus , prompted us to investigate the epidemiology of AAV in the United Kingdom . (bvsalud.org)
- Vaccines with both inactivated and live attenuated virus have proven effective in immunizing against the infection. (lookformedical.com)
- A heterogeneous group of infections produced by coxsackieviruses, including HERPANGINA , aseptic meningitis ( MENINGITIS, ASEPTIC ), a common-cold-like syndrome, a non-paralytic poliomyelitis-like syndrome, epidemic pleurodynia (PLEURODYNIA, EPIDEMIC) and a serious MYOCARDITIS . (lookformedical.com)
- 10.1186/1742-4682-7-1 cases, animal-to-animal transmission illness if infection occurs. (cdc.gov)
- IMPORTANCE: HCV infection is a major health problem. (birmingham.ac.uk)