Virus diseases caused by the ADENOVIRIDAE.
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Providing an investigational therapy to a patient who is not eligible to receive that therapy in a clinical trial, but who has a serious or life-threatening illness for which other treatments are not available. Compassionate use trials allow patients to receive promising but not yet fully studied or approved therapies when no other treatment option exists. Also called expanded access trial.
Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses.
Species of the genus MASTADENOVIRUS, causing a wide range of diseases in humans. Infections are mostly asymptomatic, but can be associated with diseases of the respiratory, ocular, and gastrointestinal systems. Serotypes (named with Arabic numbers) have been grouped into species designated Human adenovirus A-F.
An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)
Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
DEFENSINS found in azurophilic granules of neutrophils and in the secretory granules of intestinal PANETH CELLS.
The outer protein protective shell of a virus, which protects the viral nucleic acid.
Family of antimicrobial peptides that have been identified in humans, animals, and plants. They are thought to play a role in host defenses against infections, inflammation, wound repair, and acquired immunity.
Proteins that form the CAPSID of VIRUSES.
Intracellular step that follows VIRUS INTERNALIZATION during which the viral nucleic acid and CAPSID are separated.
Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Glycogenosis due to muscle phosphorylase deficiency. Characterized by painful cramps following sustained exercise.
Incorrect diagnoses after clinical examination or technical diagnostic procedures.
Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.
A sudden intense and continuous aggravation of a state of asthma, marked by dyspnea to the point of exhaustion and collapse and not responding to the usual therapeutic efforts.
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
A part of the upper respiratory tract. It contains the organ of SMELL. The term includes the external nose, the nasal cavity, and the PARANASAL SINUSES.
The reciprocal interaction of physicians and nurses.
A family of very small DNA viruses containing a single molecule of single-stranded DNA and consisting of two subfamilies: PARVOVIRINAE and DENSOVIRINAE. They infect both vertebrates and invertebrates.
Virus infections caused by the PARVOVIRIDAE.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, infecting a variety of vertebrates including humans. Parvoviruses are responsible for a number of important diseases but also can be non-pathogenic in certain hosts. The type species is MINUTE VIRUS OF MICE.
A genus of PARVOVIRIDAE, subfamily DENSOVIRINAE, comprising helper-independent viruses containing only two species. Junonia coenia densovirus is the type species.
A subfamily of DNA vertebrate viruses, in the family PARVOVIRIDAE. There are three genera: PARVOVIRUS; ERYTHROVIRUS; and DEPENDOVIRUS.
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, and containing the type species PARVOVIRUS B19, HUMAN.
A species of AVIBIRNAVIRUS causing severe inflammation of the bursa of Fabricius in chickens and other fowl. Transmission is thought to be through contaminated feed or water. Vaccines have been used with varying degrees of success.
Virus diseases caused by the BIRNAVIRIDAE.
An epithelial outgrowth of the cloaca in birds similar to the thymus in mammals. It atrophies within 6 months after birth and remains as a fibrous remnant in adult birds. It is composed of lymphoid tissue and prior to involution, is the site of B-lymphocyte maturation.
Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.
Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.
Infections produced by reoviruses, general or unspecified.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
A genus of ADENOVIRIDAE that infects birds. The type species is FOWL ADENOVIRUS A.
A genus of ADENOVIRIDAE that comprises viruses of several species of MAMMALS and BIRDS. The type species is Ovine adenovirus D.
A collection of lymphoid nodules on the posterior wall and roof of the NASOPHARYNX.
A genus of ADENOVIRIDAE that infects MAMMALS including humans and causes a wide range of diseases. The type species is Human adenovirus C (see ADENOVIRUSES, HUMAN).
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
A general term for diseases produced by viruses.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
The privacy of information and its protection against unauthorized disclosure.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
Virus diseases caused by the PICORNAVIRIDAE.

Adenoviral gene transfer of the human V2 vasopressin receptor improves contractile force of rat cardiomyocytes. (1/761)

BACKGROUND: In congestive heart failure, high systemic levels of the hormone arginine vasopressin (AVP) result in vasoconstriction and reduced cardiac contractility. These effects are mediated by the V1 vasopressin receptor (V1R) coupled to phospholipase C beta-isoforms. The V2 vasopressin receptor (V2R), which promotes activation of the Gs/adenylyl cyclase system, is physiologically expressed in the kidney but not in the myocardium. Expression of a recombinant V2R (rV2R) in the myocardium could result in a positive inotropic effect via the endogenous high concentrations of AVP in heart failure. METHODS AND RESULTS: A recombinant adenovirus encoding the human V2R (Ad-V2R) was tested for its ability to modulate the cardiac Gs/adenylyl cyclase system and to potentiate contractile force in rat ventricular cardiomyocytes and in H9c2 cardiomyoblasts. Ad-V2R infection resulted in a virus concentration-dependent expression of the transgene and led to a marked increase in cAMP formation in rV2R-expressing cardiomyocytes after exposure to AVP. Single-cell shortening measurements showed a significant agonist-induced contraction amplitude enhancement, which was blocked by the V2R antagonist, SR 121463A. Pretreatment of Ad-V2R-infected cardiomyocytes with AVP led to desensitization of the rV2R after short-term agonist exposure but did not lead to further loss of receptor function or density after long-term agonist incubation, thus demonstrating resistance of the rV2R to downregulation. CONCLUSIONS: Adenoviral gene transfer of the V2R in cardiomyocytes can modulate the endogenous adenylyl cyclase-signal transduction cascade and can potentiate contraction amplitude in cardiomyocytes. Heterologous expression of cAMP-forming receptors in the myocardium could lead to novel strategies in congestive heart failure by bypassing the desensitized beta-adrenergic receptor signaling.  (+info)

A single amino acid in the adenovirus type 37 fiber confers binding to human conjunctival cells. (2/761)

A 46-kDa receptor, coxsackievirus-adenovirus (Ad) receptor (CAR), mediates cell attachment of a number of different Ad serotypes; however, not all Ad serotypes utilize this receptor for infection. Moreover, the precise amino acid sequences in the Ad fiber protein that mediate cell attachment have yet to be identified. We investigated the interaction of subgroup D Ads with human ocular cells. Ad serotype 37 (Ad37), a virus associated with epidemic keratoconjunctivitis, but not a closely related virus serotype, Ad19p, exhibited preferential binding to and infection of human conjunctival cells. A single amino acid substitution in the Ad19p fiber distal domain (knob), Glu240 to Lys, conferred binding to conjunctival cells, while the reverse substitution in the Ad37 fiber abrogated cell binding. These findings provide new information on the fiber sequences that regulate Ad host cell tropism.  (+info)

Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction. (3/761)

BACKGROUND: The use of molecular biological techniques has demonstrated the importance of enteroviral infection of the myocardium in the pathogenesis of myocarditis and dilated cardiomyopathy in adults and adenovirus and enterovirus infection in children. The aim of this study was to determine the frequency of adenoviral infection of the myocardium of adults with impaired left ventricular function of unknown origin. METHODS AND RESULTS: Nested polymerase chain reaction (nPCR) was used to determine the frequency of detection of adenoviral DNA and enteroviral RNA in myocardial tissue samples from 94 adult patients with idiopathic left ventricular dysfunction and 14 control patients. Histological and immunohistological analyses were performed to detect myocardial inflammation. Adenoviral genomic DNA was detected by nPCR in 12 of the 94 patients with left ventricular dysfunction (in each case, adenovirus type 2), whereas enteroviral RNA was detected in another 12 patients. All control samples were negative for both viruses. In all patients, active myocarditis was excluded according to the Dallas criteria. However, there was significantly decreased CD2, CD3, and CD45RO T lymphocyte counts in the adenovirus-positive group compared with the adenovirus-negative group (P<0.05), whereas no differences were associated with enterovirus infection. CONCLUSIONS: Although enteroviruses are an important causative agent in the pathogenesis of myocarditis and dilated cardiomyopathy, this study shows that adenovirus infection is also important in the pathogenesis of left ventricular failure in adults. However, the pathogenetic basis of disease associated with adenovirus infection may be different than that after infection with other agents, particularly with respect to activation of the host immune response.  (+info)

Adenovirus infection after pediatric bone marrow transplantation. (4/761)

Retrospective analysis of 206 patients undergoing 215 consecutive bone marrow transplants (BMT) at St Jude Children's Research Hospital between November 1990 and December 1994 identified 6% (seven male, six female) with adenovirus infection. The affected patients had a median age of 7.9 years (range 3-24 years) at time of transplantation. Although transplants were performed for hematologic malignancies, solid tumors or nonmalignant conditions, only patients with hematologic malignancies had adenoviral infections. Adenovirus was first detected at a median of 54 days (range -4 to +333) after BMT. Adenovirus developed in eight of 69 (11.6%) patients receiving grafts from matched unrelated or mismatched related donors, in four of 52 (7.7%) receiving grafts from HLA-matched siblings, and in one of 93 (1.1%) receiving autografts. The most common manifestation of adenovirus infection was hemorrhagic cystitis, followed by gastroenteritis, pneumonitis and liver failure. The incidence of adenovirus infection in pediatric BMT patients at our institution is similar to that reported in adult patients. Using univariate analysis, use of total body irradiation and type of bone marrow graft were significant risk factors for adenovirus infection. Only use of total body irradiation remained as a factor on multiple logistic regression analysis.  (+info)

Lesions and transmission of experimental adenovirus hemorrhagic disease in black-tailed deer fawns. (5/761)

Adenovirus infection was the cause of an epizootic of hemorrhagic disease that is believed to have killed thousands of mule deer (Odocoileus hemionus) in California during the latter half of 1993. A systemic vasculitis with pulmonary edema and hemorrhagic enteropathy or a localized vasculitis associated with necrotizing stomatitis/pharyngitis/glossitis or osteomyelitis of the jaw were common necropsy findings in animals that died during this epizootic. To study transmission of adenovirus infection in deer and susceptibility of black-tailed deer (Odocoileus hemionus columbianus) fawns to adenovirus infection, six 3-6-month-old black-tailed fawns were divided into two treatment groups. One group was inoculated intravenously and the other group was inoculated through the mucous membranes of the eyes, nose and mouth with purified adenovirus. Each treatment group also included two additional fawns (four total) that were not inoculated but were exposed to inoculated animals (contact animals). One fawn served as a negative control. Between 4 and 16 days postinoculation, 8/10 fawns developed systemic or localized infection with lesions identical to lesions seen in animals with natural disease that died during the epizootic. Transmission was by direct contact, and the route of inoculation did not affect the incubation period or the distribution of the virus (systemic or the localized infection). Immunohistochemical analysis using polyclonal antiserum against bovine adenovirus type 5 demonstrated staining in endothelial cells of vessels in numerous tissues in animals with systemic infection and endothelial staining only in vessels subtending necrotic foci in the upper alimentary tract in animals with the localized form of the disease. All inoculated or exposed animals had staining in the tonsillar epithelium. Transmission electron microscopic examination of lung and ileum from two fawns with pulmonary edema and hemorrhagic enteropathy demonstrated endothelial necrosis and adenovirus virions in endothelial cell nuclei. Adenovirus was reisolated in black-tailed deer pulmonary artery endothelial cells using lung homogenate of the first fawn that developed systemic adenovirus infection. Serum virus neutralization test results suggest that this deer adenovirus is a new serotype.  (+info)

Gene transfer to human pancreatic endocrine cells using viral vectors. (6/761)

We have studied the factors that influence the efficiency of infection of human fetal and adult pancreatic endocrine cells with adenovirus, murine retrovirus, and lentivirus vectors all expressing the green fluorescent protein (Ad-GFP, MLV-GFP, and Lenti-GFP, respectively). Adenoviral but not retroviral vectors efficiently infected intact pancreatic islets and fetal islet-like cell clusters (ICCs) in suspension. When islets and ICCs were plated in monolayer culture, infection efficiency with all three viral vectors increased. Ad-GFP infected 90-95% of the cells, whereas infection with MLV-GFP and Lenti-GFP increased only slightly. Both exposure to hepatocyte growth factor/scatter factor (HGF/SF) and dispersion of the cells by removal from the culture dish and replating had substantial positive effects on the efficiency of infection with retroviral vectors. Studies of virus entry and cell replication revealed that cell dispersion and stimulation by HGF/SF may be acting through both mechanisms to increase the efficiency of retrovirus-mediated gene transfer. Although HGF/SF and cell dispersion increased the efficiency of infection with MLV-GFP, only rare cells with weak staining for insulin were infected, whereas approximately 25% of beta-cells were infected with Lenti-GFP. We conclude that adenovirus is the most potent vector for ex vivo overexpression of foreign genes in adult endocrine pancreatic cells and is the best vector for applications where high-level but transient expression is desired. Under the optimal conditions of cell dispersion plus HGF/SF, infection with MLV and lentiviral vectors is reasonably efficient and stable, but only lentiviral vectors efficiently infect pancreatic beta-cells.  (+info)

Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. (7/761)

To understand the function of specific proteins in sensory hair cells, it is necessary to add or inactivate those proteins in a system where their physiological effects can be studied. Unfortunately, the usefulness of heterologous expression systems for the study of many hair cell proteins is limited by the inherent difficulty of reconstituting the hair cell's exquisite cytoarchitecture. Expression of exogenous proteins within hair cells themselves may provide an alternative approach. Because recombinant viruses were efficient vectors for gene delivery in other systems, we screened three viral vectors for their ability to express exogenous genes in hair cells of organotypic cultures from mouse auditory and vestibular organs. We observed no expression of the genes for beta-galactosidase or green fluorescent protein (GFP) with either herpes simplex virus or adeno-associated virus. On the other hand, we found robust expression of GFP in hair cells exposed to a recombinant, replication-deficient adenovirus that carried the gene for GFP driven by a cytomegalovirus promoter. Titers of 4 x 10(7) pfu/ml were sufficient for expression in 50% of the approximately 1,000 hair cells in the utricular epithelium; < 1% of the nonhair cells in the epithelium were GFP positive. Expression of GFP was evident as early as 12 h postinfection, was maximal at 4 days, and continued for at least 10 days. Over the first 36 h there was no evidence of toxicity. We recorded normal voltage-dependent and transduction currents from infected cells identified by GFP fluorescence. At longer times hair bundle integrity was compromised despite a cell body that appeared healthy. To assess the ability of adenovirus-mediated gene transfer to alter hair cell function we introduced the gene for the ion channel Kir2.1. We used an adenovirus vector encoding Kir2.1 fused to GFP under the control of an ecdysone promoter. Unlike the diffuse distribution within the cell body we observed with GFP, the ion channel-GFP fusion showed a pattern of fluorescence that was restricted to the cell membrane and a few extranuclear punctate regions. Patch-clamp recordings confirmed the expression of an inward rectifier with a conductance of 43 nS, over an order of magnitude larger than the endogenous inward rectifier. The zero-current potential in infected cells was shifted by -17 mV. These results demonstrate an efficient method for gene transfer into both vestibular and auditory hair cells in culture, which can be used to study the effects of gene products on hair cell function.  (+info)

Tracheal aspirate as a substrate for polymerase chain reaction detection of viral genome in childhood pneumonia and myocarditis. (8/761)

BACKGROUND: Infectious respiratory disorders are important causes of childhood morbidity and mortality. Viral causes are common and may lead to rapid deterioration, requiring mechanical ventilation; myocardial dysfunction may accompany respiratory decompensation. The etiologic viral diagnosis may be difficult with classic methods. The purpose of this study was to evaluate polymerase chain reaction (PCR) as a diagnostic method for identification of causative agents. METHODS AND RESULTS: PCR was used to amplify sequences of viruses known to cause childhood viral pneumonia and myocarditis. Oligonucleotide primers were designed to amplify specific sequences of DNA virus (adenovirus, cytomegalovirus, herpes simplex virus, and Epstein-Barr virus) and RNA virus (enterovirus, respiratory syncytial virus, influenza A, and influenza B) genomes. Tracheal aspirate samples were obtained from 32 intubated patients and nucleic acid extracted before PCR. PCR results were compared with results of culture, serology, and antigen detection methods when available. In cases of myocarditis (n=7), endomyocardial biopsy samples were analyzed by PCR and compared with tracheal aspirate studies. PCR amplification of viral genome occurred in 18 of 32 samples (56%), with 3 samples PCR positive for 2 viral genomes. Amplified viral sequences included RSV (n=3), enterovirus (n=5), cytomegalovirus (n=4), adenovirus (n=3), herpes simplex virus (n=2), Epstein-Barr virus (n=1), influenza A (n=2), and influenza B (n=1). All 7 cases of myocarditis amplified the same viral genome from heart as found by tracheal aspirate. CONCLUSIONS: PCR is a rapid and sensitive diagnostic tool in cases of viral pneumonia with or without myocarditis, and tracheal aspirate appears to be excellent for analysis.  (+info)

TY - JOUR. T1 - Adenovirus infections in heart transplantation. AU - Florescu, Diana F.. AU - Kwon, Joong Y.. AU - Dumitru, Ioana. PY - 2013/7. Y1 - 2013/7. N2 - Adenovirus infections have been associated with significant morbidity and mortality in immunocompromised hosts. The clinical significance of adenovirus disease in heart transplantation is not well-defined; in particular, the significance of adenovirus identification in myocardium remains unclear. Although severe adenovirus disease has been described in heart transplant recipients, adenovirus infections seem to be more frequently associated with increased risk of adverse cardiac events, such as rejection, ventricular dysfunction, coronary vasculopathy, need for retransplantation, and graft loss because of death. Cidofovir is currently considered the standard of treatment for adenovirus disease not responding to reduction of immunosuppression.. AB - Adenovirus infections have been associated with significant morbidity and mortality in ...
TY - JOUR. T1 - Safety and Efficacy of CMX001 as Salvage Therapy for Severe Adenovirus Infections in Immunocompromised Patients. AU - Florescu, Diana F.. AU - Pergam, Steven A.. AU - Neely, Michael N.. AU - Qiu, Fang. AU - Johnston, Christine. AU - Way, SingSing. AU - Sande, Jane. AU - Lewinsohn, Deborah. AU - Guzman-Cottrill, Judith. AU - Graham, Michael L.. AU - Papanicolaou, Genovefa. AU - Kurtzberg, Joanne. AU - Rigdon, Joseph. AU - Painter, Wendy. AU - Mommeja-Marin, Herve. AU - Lanier, Randall. AU - Anderson, Maggie. AU - van der Horst, Charles. PY - 2012/5. Y1 - 2012/5. N2 - No therapeutic agent has yet been established as the definitive therapy for adenovirus infections. We describe the clinical experience of 13 immunocompromised patients who received CMX001 (hexadecyloxypropyl cidofovir), an orally bioavailable lipid conjugate of cidofovir, for adenovirus disease. We retrospectively analyzed 13 patients with adenovirus disease and viremia treated with CMX001; data were available for ...
Purpose : Mechanisms used by epidemic keratoconjunctivitis (EKC)-causing adenoviruses to overcome the mucosal barrier of the ocular surface epithelium and initiate infection remain unknown. At the 2015 ARVO General Meeting, we reported that an EKC-causing adenovirus, but not a non-EKC-causing one, induces release of the ectodomain of MUC16 - a membrane-associated mucin (MAM) with barrier functions - from human corneal epithelial cells. The purpose of this study is to determine if MUC16 ectodomain release facilitates adenoviral infection of ocular surface epithelial cells. Methods : Telomerase-immortalized human corneal-limbal epithelial (HCLE) cells, grown to confluence and allowed to differentiate for optimal mucin expression, were exposed to human adenoviruses HAdV-D37 (EKC-causing) and HAdV-D19p (non-EKC-causing) at an MOI of 3. As a measure of epithelial barrier function, rose bengal dye penetrance assays were performed on HCLE cells exposed to HAdV-D37 and HAdV-D19p for 2 h. To compare ...
Infection of mice or rats with adenoviruses can alter their normal immune response and thereby skew experimental data. For example, infection with MAD-1 can produce extensive persistent lesions in the kidneys of adult mice and render them more susceptible to experimental Escherichia coli-induced pyelonephritis. Mouse adenovirus infection has also been shown to accelerate experimental scrapie infection in mice. Although mouse adenoviral infection is usually subclinical in immunocompetent mice, wasting may result in nude mice. ...
Adenoviruses (HAdV) can cause serious life threatening infections, especially in pediatric patients after allogeneic stem cell transplantation (SCT). To improve the morbidity and mortality rate of HAdV infected patients after SCT three issues have been explored: which patients are at risk for HAdV infection, what is the best treatment for ... read more HAdV infected patients and when do we start treatment. We found that in pediatric patients HAdV-DNA positivity in nasopharyngeal aspirate before SCT is a very important risk factor for developing invasive HAdV infection after SCT. As determined with multiplex immuno-assay we also found that children with a localized HAdV infection have a different cytokine profile compared with patients with an invasive HAdV infection after SCT. Cytokine signatures can also be helpful to differentiate invasive HAdV infection from other SCT related complications as Graft versus Host Disease (GvHD) and Epstein-barr virus infection. Immune profiling could possibly ...
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Synonyms for Adenoviridae in Free Thesaurus. Antonyms for Adenoviridae. 2 words related to adenovirus: parainfluenza virus, animal virus. What are synonyms for Adenoviridae?
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BOSC23 cells were transfected with pMSCV PPAR employing Fugene transfection reagent based on the manufacturers protocol. Peroxisome proliferator activated receptor is necessary to allow the differentiation of MEFs ATP-competitive HSP90 inhibitor into adipocytes. The medium then was modified soon after overnight incubation. After 24 h, viral supernatants were filtered by a 0. 45 M Whatman filter and made use of to infect the target cells. The target cells were subjected to two to three rounds of infection and after that underwent assortment working with puromycin. Adenoviral infection of cells. Ad GFP and Ad Cre viruses have been ready with the University of Pennsylvania Gene Treatment Vector Core. Adenovirus was extra to two. 5 ml DMEM at a multiplicity of infection of one,000 for 15 min. Individually, 18 l of Lipofectamine 2000 reagent was extra to two.. five ml of DMEM. The preparations then have been mixed together and incubated for an extra 15 min, following which the mixture was added to ...
Evidence that activation due to anti-adenovirus antibodies may have been responsible for the increased risk of HIV infection in the STEP vaccine trial
Looking for online definition of Adenoviridae infections in the Medical Dictionary? Adenoviridae infections explanation free. What is Adenoviridae infections? Meaning of Adenoviridae infections medical term. What does Adenoviridae infections mean?
Mouse adenovirus causes a persistent infection in the mouse kidney that produces extensive mononuclear cell infiltrates in cortex and medulla. Tubular necrosis, dilatation, and occasional collapse occur but no glomerular changes or periglomerular fibrosis have been observed. Acute and chronic adenovirus infection of the kidney predispose the kidney to develop acute pyelonephritis when the mouse is challenged by the intravenous or retrograde route with Escherichia coli. ...
Adenovirus vectors have significant potential for long- or short-term gene transfer. Preclinical and clinical studies using human derived adenoviruses (HAd) have demonstrated the feasibility of flexible hybrid vector designs, robust expression and induction of protective immunity. However, clinical use of HAd vectors can, under some conditions, be limited by pre-existing vector immunity. Pre-existing humoral and cellular anti-capsid immunity limits the efficacy and duration of transgene expression and is poorly circumvented by injections of larger doses and immuno-suppressing drugs. This review updates canine adenovirus serotype 2 (CAV-2, also known as CAdV-2) biology and gives an overview of the generation of early region 1 (E1)-deleted to helper-dependent (HD) CAV-2 vectors. We also summarize the essential characteristics concerning their interaction with the anti-HAd memory immune responses in humans, the preferential transduction of neurons, and its high level of retrograde axonal transport in the
Doctors Ask: Adenovirus infection is exposed to all segments of the population. Basic manifestations of adenovirus infection The latent (incubation period) is usually 5-7 days. The disease most often begins acutely, from the phenomena of intoxication: slight increase in temperature, rashes in the body, chills, lethargy, headache, loss of appetite, etc.
Adenovirus infection generally may lead to common cold, pneumonia and pharyngitis.There are few types of adenoviruses. Specifically, adenoviruses types 8,19 and 37 will lead to keratoconjunctivitis mostly in adult.
In one mode of adenovirus infection (called lytic infection because it destroys large numbers of cells), adenoviruses kill healthy cells and replicate up to 1 million new viruses per cell killed, of which 1 to 5 percent are infectious. People with this kind of infection feel sick. In chronic or latent infection, a much smaller number of viruses are released, and healthy cells can multiply more rapidly than they are destroyed. People who have this kind of infection do not exhibit symptoms. Children who have normal immune systems usually experience only minor symptoms when infected with adenovirus. The course of infection tends to be more serious in children who are immunocompromised, such as those undergoing chemotherapy or those who have a disease that disrupts normal immune response (e.g. human immunodeficiency syndrome [HIV]). In such children, the virus more often affects organs such as the lungs, liver, and kidneys, and the risk of fatality increases. Symptoms common to respiratory illnesses ...
Adenovirus Infections answers are found in the 5-Minute Clinical Consult powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Editors Note: Sarah D. (18) wrote this project proposal for research that he will conduct at the Icahn School of Medicine at Mount Sinai ...
The inner-city infants had lower rates of viral detection overall. This may suggest that other factors, such as bacteria or allergic reactions to air pollutions or toxic exposures, contribute significantly to respiratory illness. Sick urban infants had lower rates of two kinds of viruses, HRV and RSV, and higher rates of adenovirus infections, compared to suburban infants. In the urban babies, 4.8 percent of nasal washes tested positive for only adenovirus, while just 0.7 percent of samples from suburban babies were positive for only adenovirus. Adenovirus infections, either as a single pathogen or when detected in concert with other viruses, were significantly more common in the urban population, and this held true for each of the four urban locations where our study was conducted, the authors wrote ...
My son has this virus. He has pink eye in both eyes, the sore throat, ear infection, he had a fever for 3 days, diarrhea and he has said when he watches Tv its like the tv is spinning. He gets sick so fast that he has had just about every virus out there. So far this particular virus is lasting all most a week now. I cant wait till its completely gone. He has already been out of school for 4 days.... ...
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Answer: Determine the underlying cause of the membrane/pseudomembrane and treat the underlying disease. In the case of adenoviral infection removal of the inflammatory membrane and application of topical steroids may prevent the formation of symblepharon ...
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Fingerprint Dive into the research topics of Two early mRNA species in adenovirus type 2 transformed rat cells. Together they form a unique fingerprint. ...
Looking for online definition of canine adenovirus type 2 (CAV-2) in the Medical Dictionary? canine adenovirus type 2 (CAV-2) explanation free. What is canine adenovirus type 2 (CAV-2)? Meaning of canine adenovirus type 2 (CAV-2) medical term. What does canine adenovirus type 2 (CAV-2) mean?
Zhao, J., Q. Zhong, Y. Zhao, Y.-x. Hu, and G.-z. Zhang, Pathogenicity and Complete Genome Characterization of Fowl Adenoviruses Isolated from Chickens Associated with Inclusion Body Hepatitis and Hydropericardium Syndrome in China, PloS one, vol. 10, no. 7, pp. e0133073, 2015. Mase, M., H. Mitake, T. Inoue, and T. Imada, Identification of group I-III avian adenovirus by PCR coupled with direct sequencing of the hexon gene, Journal of Veterinary Medical Science, vol. 71, no. 9, pp. 1239-1242, 2009. Ginsberg, H.S., The adenoviruses. New York, Springer Science & Business Media, 2013. Russell, W., Update on adenovirus and its vectors, Journal of general virology, vol. 81, no. 11, pp. 2573-2604, 2000. Joubert, H.W., H. Aitchison, L.H. Maartens, and E.H. Venter, Molecular differentiation and pathogenicity of Aviadenoviruses isolated during an outbreak of inclusion body hepatitis in South Africa, Journal of the South African Veterinary Association, vol. 85, no. 1, pp. 01-08, 2014. Steer, P.A., ...
Canine Adenovirus Pneumonia in 2 puppies- CAV-2 History: Two English Bulldog puppies (1, and 3 weeks old) had trouble breathing in the morning and by noon had died. Gross Necropsy Findings: Lungs: Diffuse dark red to purple, edematous. Histologic Findings: Lungs: Multifocal necrosis of bronchiolar respiratory epithelium and alveolar pneumocytes. Alveolar septa are expanded by…
TY - JOUR. T1 - Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients. AU - Muller, William J.. AU - Levin, Myron J.. AU - Shin, Young Kyoo. AU - Robinson, Christine. AU - Quinones, Ralph. AU - Malcolm, Janet. AU - Hild, Elaine. AU - Gao, Dexiang. AU - Giller, Roger. PY - 2005/12/15. Y1 - 2005/12/15. N2 - Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT patients, 18 of whom had severe manifestations of infection. Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 patients. In vitro susceptibility to cidofovir was demonstrated in 12 clinical adenovirus isolates. Cidofovir is a promising treatment option for this population.. AB - Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT ...
Inclusion body hepatitis caused by different fowl aviadenovirus (FAdV) serotypes has been described in several countries in recent years. In Spain, from the spring of 2011 to 2013, an increased number of outbreaks in broiler and broiler breeder flocks from different regions occurred. The objectives of the present work were to carry out the molecular characterization of FAdV strains from Spanish inclusion body hepatitis cases and to study the pathogenicity and viral dynamics of these strains in specific pathogen-free (SPF) chickens. A total of 52 inclusion body hepatitis clinical cases, including 45 from broiler farms and seven from broiler breeder farms, were analysed by conventional polymerase chain reaction and sequencing targeting the FAdV hexon gene. From these, 37 strains were classified as FAdV type 8b, while the remaining 15 were classified as FAdV types 11 (n = 10), 2 (n = 4) and 8a (n = 1). In addition, two different FAdVs belonging to the genotypes 8b and 11 were used for experimental ...
In the present study we compared CAR, αv integrin, and adenovirus transgene expression levels in cells cultured from normal tissues (breast, kidney, and liver) with cancer cell lines derived from those tissues and were able to demonstrate that the cancer cell lines are more sensitive to FK228. The observation that 1 ng/ml FK228 preferentially increased the number of infected cells expressing the transgene in cancer cell lines suggests a strategy that may render malignant cells more susceptible to adenoviral infection than normal cells in vivo. Such an approach could be used to increase the effectiveness of adenoviral infection, whereas reducing undesirable side effects that may result to normal tissue from high levels of adenovirus infection.. The mechanism by which FK228 exerts it effect is most likely through an alteration of histone acetylation. FK228 has been shown to be a HDAC inhibitor, and we have demonstrated an increase in histone H3 acetylation in this study after FK228 treatment (16) ...
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86 PCR positive samples were inoculated onto Hep-2 cell for virus isolation, and 23 HAdV strains were isolated through 7-21 days post-inoculation, with isolation rate of 26.74%, which was close to that of 21.43% in the previous study (Thounaojam et al. 2016). The hexon gene sequence has widely been used for the classification of adenovirus types. In this study, the hexon gene of the 23 HAdV isolates was amplified and sequenced using primer designed by Sarantis et al. (Sarantis et al. 2004) (Forward primer: 5′-CTGATGTACTACAACAGCACTGGCAACATGGG-3′, Reverse primer: 5′-GCGTTGCGGTGGTGGTTAAATGGGTTTACGTTGTCCAT-3′, the amplicon length is 580-605 bp), and the nucleotide sequences were submitted to GenBank (accession numbers MN389388-MN389410). Molecular typing assignments were based on the identity of the closest matching sequences after both BLAST and phylogenetic analysis. Results showed that 9 of the 23 HAdV isolates (8 HAdV-3 and 1 HAdV-7) belonged to species B and 12 of the 23 (5 HAdV-1 and 7 ...
As combining therapeutic agents with different action mechanisms may enhance efficacy, YSC-02, an oncolytic adenovirus with multi targets was loaded with five different genes, which were designed with the expectation that different action mechanisms would cooperate. In spite of concerns regarding many APIs, YSC-02 was constructed to be an adenovirus-based anti-cancer drug. By using our own established mouse model system suitable for efficient adenoviral infection and replication, immune activity as well as survival potential could be precisely estimated for anti-cancer drug efficacy. YSC-02 was designed to decrease tumor cell survival, metastasis and to increase tumor cell death, and immune activation. It is composed of five different target genes, including one fused form and two shRNAs, but each of these genes functions is closely linked to produce the maximal antitumor effect. YSC-02 is like an organic complex designed to be applied primarily to heterogeneous liver cancer and melanoma. The ...
Vincent and Rich speak with Alice and Kathy about their work on HIV genome dimerization, and packaging and pathogenesis of mouse adenovirus.
Feucht, Judith; Opherk, Kathrin; Lang, Peter; Kayser, Simone; Hartl, Lena; Bethge, Wolfgang; Matthes-Martin, Susanne; Bader, Peter; Albert, Michael H.; Maecker-Kolhoff, Britta; Greil, Johann; Einsele, Hermann; Schlegel, Paul-Gerhardt; Schuster, Friedhelm R.; Kremens, Bernhard; Rossig, Claudia; Gruhn, Bernd; Handgretinger, Rupert; Feuchtinger, Tobias ...
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Adenoviruses are ubiquitous. Weve all been infected with lots of them (gets to be a problem when making gene therapy vectors). The older you are, the more likely you have been exposed to the different kinds of adenovirus, to the point where if you are an adult reading this, you probably have antibodies to serotypes 1, 2, 5, and/or 6 (depending on where you live).. Thus older children are more likely to have been exposed to any adenovirus, including Ad-36. If your obese group of children is 63% kids aged 15-18, and your healthy weight group is only 17% 15-18, I am not shocked at all that antibodies to Ad-36 is correlated with obesity. I bet you could have picked any other adenovirus serotype and found the same correlation. But they didnt look.. William M. Briggs gets it. I dunno the dude. Statistician. But he gets it. *thumbs-up*. From a virologists perspective, there are putative, plausible mechanisms for how Ad-36 could actually play a role in obesity. Those reasonings require ongoing ...
Adenovirus Type 9, 0.1 mg. The many different serotypes of human adenoviruses (Ad) are divided into six subgroups, of which all Ad subgroup A and B and two subgroup D Ads can elicit tumors in infected rodents.
This post is about adenovirus infection, a major cause of illness both minor and severe in the United States, especially among children in group settings.
Publications 164 Publications PUBLICATIONS 1. Heemskerk B, Veltrop-Duits LA, van Vreeswijk T, ten Dam MM, Heidt S, Toes RE, van Tol MJ, Schilham MW. Extensive cross-reactivity of CD4 + adenovirus-specific
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NEW YORK (GenomeWeb News) - Researchers from China and the US will sequence 100 human adenoviruses, including ones that cause respiratory, gastrointestinal, and ocular diseases, under a partnership announced today.
-Maintains strong financial position with $314.5 million in capital at quarter end-. DURHAM, N.C., May 09, 2016-- Chimerix, a biopharmaceutical company developing novel antivirals to address unmet medical needs, today reported top-line results from an interim analysis of the AdVise trial of brincidofovir for serious adenovirus infection and other corporate...
Looking for inclusion body hepatitis? Find out information about inclusion body hepatitis. Any of the abnormal structures appearing within the cell nucleus or the cytoplasm during the course of virus multiplication Explanation of inclusion body hepatitis
Human adenovirus, of the Adenoviridae family, is a nonenveloped icosahedral particle containing a single linear dsDNA genome. Human adenovirus comprises 6 species (A through F) consisting of serotypes 1 - 51, and associated with a variety of clinical illnesses. Serotypes 1-39, 42-51 are associated with a variety of respiratory disease, generally in children and immunocompromised persons; whereas serotypes 40 and 41 is associated with enteric disease (enteric adenovirus) particularly in children - these enteric adenoviruses will not be detected with the assay described here. Serotypes 12, 18, 31 have a high oncogenic potential and serotypes 4 and 7 are associated with acute respiratory disease (ARD) frequently in military recruits and typically occur in the winter and spring. Smaller outbreaks of serotypes 3, 4, and 7 occur in the summertime and are associated with contaminated swimming pool water.. Adenovirus infections of the eye may lead to pharyngo-conjunctival fever, follicular ...
Corneal subepithelial infiltrates are a known complication of adenoviral conjunctivitis.1 These lesions usually become apparent within 10-14 days after onset of symptoms and in some cases may persist for months or even years after the acute phase of the infection. Although the opacities gradually fade with time, those associated with reduced visual acuity may require a course of topical corticosteroids. However, return of the opacities can be seen with discontinuation of the corticosteroids.2 In cases of prolonged follicular conjunctivitis, equivocal ocular signs, or suspected superimposed infections, specimen culture is an important tool to aid diagnosis.3,4. Although small star-shaped ulcers (herpetic stellates) have been documented as a clinical manifestation seen in herpes simplex eye infections,5 these lesions have been confined to the corneal epithelium. To our knowledge, no such lesions have been documented in the tarsoconjunctiva, either in adenoviral or herpes simplex viral ...
Enteric viruses transmitted via the faecal-oral route occur in high concentrations in wastewater and may contaminate drinking water sources and cause disease. In order to quantify enteric adenovirus...
Albinana-Gimenez N., M.P. Miagostovich, B. Calgua, J.M. Huguet, L. Matia and R. Girones. 2009. Analysis of adenoviruses and polyomaviruses quantified by qPCR as indicators of water quality in source and drinking-water treatment plants. Water Res. 43:2011-2019. [PubMed]. Barrella K.M., P. Garrafa, T.A. Monezi, C.M. Harsi, C. Salvi, P.A. Violante and D.U. Mehnert. 2009. Longitudinal study on occurrence of adenoviruses and hepatitis A virus in raw domestic sewage in the city of Limeira, Sao Paulo. Braz. J. Microbiol. 40:102-107. [PubMed]. Bibby K. and J. Peccia. 2013. Prevalence of respiratory adenovirus species B and C in sewage sludge. Environ. Sci. Process Impacts. 15(2):336-8 [PubMed]. Cantalupo P.G, B. Calgua, G. Zhao, A. Hundesa, A.D. Wier, J.P. Katz, M. Grabe, R.W. Hendrix, R. Girones, D. Wang and others. 2011. Raw sewage harbors diverse viral populations. MBio. 2(5):e00180-11 [PubMed]. Cruz J.R., P. Caceres, F. Cano, J. Flores, A. Bartlett and B. Torun. 1990. Adenovirus types 40 and 41 and ...
Alonso-Padilla J, Papp T, Kaján GL, Benkő M, Havenga M, Lemckert A, Harrach B, Baker AH (2016) Development of novel adenoviral vectors to overcome challenges observed with HAdV-5 based constructs. Mol Ther. 24:6-16. doi:10.1038/mt.2015.194. Marek A, Kajan GL, Kosiol C, Harrach B, Schlotterer C, Hess M (2014) Complete genome sequences of pigeon adenovirus 1 and duck adenovirus 2 extend the number of species within the genus Aviadenovirus. Virology 462-463C:107-114. doi:10.1016/j.virol.2014.04.033. Kaján GL, Kecskeméti S, Harrach B, Benkő M (2013) Molecular typing of fowl adenoviruses, isolated in Hungary recently, reveals high diversity. Vet Microbiol. 167:357-363. doi:10.1016/j.vetmic.2013.09.025. Marek A, Kosiol C, Harrach B, Kaján GL, Schlötterer C, Hess M (2013) The first whole genome sequence of a Fowl adenovirus B strain enables interspecies comparisons within the genus Aviadenovirus. Vet Microbiol. 166:250-256. doi: 10.1016/j.vetmic.2013.05.017. Zadravec M, Slavec B, Krapez U, Kajan ...
The present study describes the development of a SYBR Green based real-time polymerase chain reaction (real-time PCR) for detection and quantitation of all fowl adenovirus (FAdV) species. Primers were designed based on conserved nucleotide sequences within the 52K gene. Ten-fold serial dilutions of a vector DNA were used as standard for quantitation. The real-time PCR had an efficiency of 98%, a regression squared value of 0.999 and showed a range of 6.73-6.73×10(8) copies of FAdV DNA per reaction. The assay was highly specific for FAdVs and an exact quantitation of all 5 FAdV species (FAdV-A to FAdV-E) could be demonstrated. It was shown, that twelve FAdV serotypes (FAdV-1 to 8a, and 8b to 11) were detectable and quantifiable. Other viral genomes as well as uninfected chicken embryo liver (CEL) cells did not produce positive signal. Cloacal swabs were taken during the animal experiment, which was performed with all FAdV species. Shedding of FAdVs was investigated in cell culture, by ...
Nobivac Intra-Trac 3 25 Dose, Nobivac Canine is for the vaccination of healthy dogs as an aid in prevention of infectious disease associated with canine adenovirus type 2, canine parainfluenza virus,
Univac 5 dog shot is a modified-live virus for the vaccination of healthy, susceptible dogs and puppies as an aid in the reduction of diseases caused by canine distemper, canine adenovirus types 1 and 2, parainfluenza and parvovirus. Dosage: 1 ml IM or subcut, repeat in 3-4 weeks. Puppies vaccinated before 9 weeks should be revaccinated at
The oncolytic potency of CRAds is critically linked to effective adenoviral infection and replication. First, there must be efficient infection in target cells. To this end, we have shown gains in infectivity via CAR-independent infection to overcome the hurdle that most tumor cells are deficient with respect to the level of the CAR receptor. These gains provide a logical framework for addressing other biological factors related to CRAd potency, such as efficacy of replication, as studied here. Furthermore, elucidation of distinct mechanisms will allow us to develop a strategy to circumvent other barriers and improve the potency of CRAds. In the present study, we endeavored to define the replicative blocks that may be limiting the full potential of oncolytic CRAds.. We showed that immortalized cell lines support wild-type adenoviral replication to a much greater degree than primary patient tumors. Because fiber and hexon are both late proteins involved in the assembly of virions, it was expected ...
Abstract Background Viruses bind to specific cellular receptors in order to infect their hosts. The specific receptors a virus uses are important factors in determining host range, cellular tropism, and pathogenesis. For adenovirus, the existing model of entry requires two receptor interactions. First, the viral fiber protein binds Coxsackie and Adenovirus Receptor (CAR), its primary cellular receptor, which docks the virus to the cell surface. Next, viral penton base engages cellular integrins, coreceptors thought to be required exclusively for internalization and not contributing to binding. However, a number of studies reporting data which conflicts with this simple model have been published. These observations have led us to question the proposed two-step model for adenovirus infection. Results In this study we report that cells which express little to no CAR can be efficiently transduced by adenovirus. Using competition experiments between whole virus and soluble viral fiber protein or ...
Adenovirus and pregnancy - What is adenovirus infection? Many forms. This virus can produce several forms of infection. Pharyngo-conjunctival fever (or swimming pool fever) is one of the better known, but also gastroenteritis, upper respiratory tract infections and pneumonia can all occur.
Human adenovirus 12 ATCC ® VR-863D™ Designation: DNA from Human adenovirus 12 strain Huie [ATCC ® VR-863™] Application: It is suitable for use in polymerase chain reaction (PCR) for viral gene products and other molecular virology applications. Respiratory research
Human adenovirus 12 ATCC ® VR-863D™ Designation: DNA from Human adenovirus 12 strain Huie [ATCC ® VR-863™] Application: It is suitable for use in polymerase chain reaction (PCR) for viral gene products and other molecular virology applications. Respiratory research
13:2; potential epub Adenovirus notions; tenure bhakti 1? On the epub Adenovirus Methods and of this interest, are above under form. 1282 An epub Adenovirus Methods and Protocols: Adenoviruses, Ad study read by Porten - Szubin 1987:187.
Fingerprint Dive into the research topics of Accumulation of early and intermediate mRNA species during subgroup C adenovirus productive infections. Together they form a unique fingerprint. ...
Premade Human MIR1538 Adenovirus (NR_031719), ready-to-use and available with your choice of HA tag, His tag, GFP reporter or untagged.
Assessments for safety and tolerability as measured as the acute and late adverse effects, laboratory parameters, biodistribution of the vector, anti-adenovirus antibodies and VEGF-levels before and in several time points after the gene transfer ...
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Most infections with adenovirus result in infections of the upper respiratory tract. Adenovirus infections often present as ... Type 1 infection can also cause respiratory and eye infections. CAdV-1 also affects foxes (Vulpes vulpes and Vulpes lagopus) ... and-rarely-even previously healthy people can die of these infections. This may be because sometimes adenoviral infection can ... and avoiding close contact with people with symptomatic adenovirus infection. Those with symptomatic adenovirus infection are ...
... infection is mainly asymptomatic in most cases Adenoviridae Uropathogenic Escherichia coli (UPEC) Herpes simplex virus ... It is a commonly treatable condition usually caused by infection with bacteria. This bacterial infection is often sexually ... Bacterial infections leading to gonococcal and non-gonococcal urethritis can be prevented by: sexual abstinence use of barrier ... "Gonococcal Infections - 2015 STD Treatment Guidelines". www.cdc.gov. 2019-03-15. Retrieved 2020-07-30. Grant PM, Hooton TM ( ...
InfectionsEdit. Main article: Adenovirus infection. Most infections with adenovirus result in infections of the upper ... Type 1 infection can also cause respiratory and eye infections. CAdV-1 also affects foxes (Vulpes vulpes, Vulpes lagopus) and ... and-rarely-even previously healthy people can die of these infections.[24] This may be because sometimes adenoviral infection ... Infection, Genetics and Evolution. 8 (3): 267-85. doi:10.1016/j.meegid.2008.01.002. PMID 18295550.. ...
usually mild respiratory, gastrointestinal and eye infections. serotypes 3, 5 and 7: lower respiratory tract infections. ... Mastadenovirus is a genus of viruses, in the family Adenoviridae. Human, mammals, and vertebrates serve as natural hosts. There ... very common human infection, estimated to be responsible for between 2% and 5% of all respiratory infections. ... serotype 14: can cause potentially fatal adenovirus infections. Canine adenovirus 1 (CAdV-1) can lead to death in puppies, or ...
Infection usually results in disease of the gastrointestinal or respiratory tract. Infection may also cause ocular or ... Bovine Adenovirus, also known as BAdV, is a member of the Adenoviridae family that causes disease in cattle. There are 10 ... However, infection may not always result in disease as the virus can be isolated in healthy cattle. Once infected, the cattle ... Signs may worsen if a secondary infection occurs. The classical signs of a generalised disease, such as pyrexia, weight loss, ...
Infection is often subclinical, and when clinical signs are seen they are mild and short-lived. Gastrointestinal signs such as ... Adenoviridae Bovine adenovirus Veterinary Medicine : A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats ( ... Porcine adenovirus (aka pADV 1-5 or pADV A-C) is a member of the adenoviridae family. It causes mild gastrointestinal diseases ... Respiratory signs such as coughing can be seen if the infection is part of a multifactorial respiratory disease complex. ...
Even where an Agamid shows no signs of infection, many are believed to be sub-clinically infected, or carriers of the virus. ... Agamid adenovirus (Agamid AdV1) is a type of virus in the Adenoviridae family. The virus is widespread in captive populations ... Kim, Dae Young; Mitchell, Mark A; Bauer, Rudy W; Poston, Rob; Cho, Doo-Youn (2016). "An Outbreak of Adenoviral Infection in ... It is probable that there is a relationship between dose of infection and clinical disease. Coinfections with other agents such ...
Viral Infections and Treatment,display-editors=etal,editor-first=Helga,editor-last=Rübsamen-Waigmann,first2=Frederick G.,last2= ... Adenoviridae,adenoviruses]] (5%),,ref name=Medscape /, [[ Virusi sinkytial i frymëmarrjes njerëzore,virusi]] sinkytial i [[ ... The economic burden of non-influenza-related viral respiratory tract infection in the United States,url=,journal=Arch. Intern. ... Common colds are defined as upper respiratory tract infections that affect the predominantly nasal part of the respiratory ...
Unsurprisingly, sialic acids also play an important role in several human viral infections. The influenza viruses have ... Many viruses such as the Ad26 serotype of adenoviruses (Adenoviridae), rotaviruses (Reoviridae) and influenza viruses ( ...
A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus ... Double-stranded DNA families: three are non-enveloped (Adenoviridae, Papillomaviridae and Polyomaviridae) and two are enveloped ... "Babies Born with CMV (Congenital CMV Infection)". Centers for Disease Control and Prevention. April 13, 2017. Retrieved June 17 ... Page 273 in: Lennette's Laboratory Diagnosis of Viral Infections (Fourth ed.). CRC Press. 2010. ISBN 978-1420084962. Murillo A ...
Helminthiasis (worm infection), Ascariasis, and enterobiasis (pinworm infection) are few that are caused by various parasitic ... Pathogenic viruses are mainly those of the families of: Adenoviridae, Picornaviridae, Herpesviridae, Hepadnaviridae, ... or yeast infections. Most antibiotics that function on bacterial pathogens cannot be used to treat fungal infections because ... Life-threatening fungal infections in humans most often occur in immunocompromised patients or vulnerable people with a ...
... (ICH) is an acute liver infection in dogs caused by Canine mastadenovirus A, formerly called Canine ... "Adenoviridae". A Concise Review of Veterinary Virology. Retrieved 2006-06-10.. .mw-parser-output cite.citation{font-style: ... CAV-2 is one of the causes of respiratory infections in dogs, but it is similar enough to CAV-1 that vaccine for one creates ...
In 2017, the ChAdOx1 vector was used in a trial for a vaccine candidate against human malaria infection. The researchers ... It has been demonstrated that the adenoviridae vector ChAdOx1 can be used to make vaccinations that are protective against ... For example, a vaccine for influenza infection was designed using the vector expressing influenza antigens, nucleoprotein (NP ...
The symptoms of CAP are the result of lung infection by microorganisms and the response of the immune system to the infection. ... and adenoviridae, mumps and enterovirus can also cause pneumonia. Another cause of neonatal CAP is Chlamydia trachomatis, which ... Viral infections weaken the immune system, making the body more susceptible to bacterial infection, including bacterial ... A life-threatening reaction to infection. A common cause of sepsis is bacterial pneumonia, frequently the result of infection ...
Breuil, G., Bonami, J.R., Pepin, J.F., and Pichot, Y. (1991). Viral infection (picorna-like virus) associated with mass ... nonenveloped: Adenoviridae. *Papillomaviridae. *Papovaviridae (obsolete). *Polyomaviridae. *genera: Rhizidiovirus. * ... Mechanisms of Capsid Assembly and Viral Infection. PLoS Pathogens 11(10), e1005203. ...
For example, infection of mesenteric lymph glands of mice with Yersinia can clear the way for continuing infection of these ... Pathogenic viruses are diseases mainly of the families of: Adenoviridae, Picornaviridae, Herpesviridae, Hepadnaviridae, ... Hygiene is critical for the prevention of infection by pathogens. Sexual interactions[edit]. Many pathogens are capable of ... Infection with many pathogens can be prevented by immunization. A small amount of pathogens are used in vaccines to make ...
It then injects its DNA or RNA into the host to initiate infection. In animal cells these viruses get into the cell through the ... An example of a family within this classification is the Adenoviridae. There is only one well-studied example in which a class ... Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must ...
The presence of IgM in the blood of the host is used to test for acute infection, whereas IgG indicates an infection sometime ... Vaccination is a cheap and effective way of preventing infections by viruses. Vaccines were used to prevent viral infections ... Smallpox infections have been eradicated.[196] Vaccines are available to prevent over thirteen viral infections of humans,[197] ... Hepatitis viruses can develop into a chronic viral infection that leads to liver cancer.[179][180] Infection by human T- ...
May 17, 2007, Science Daily: Herpes infection might have an up side Citat: "...U.S. medical scientists say a herpes virus ... Adenoviridae. *Herpesviridae (skoldkopper, Epstein-Barr virus og mononukleose). *Mimiviridae Langkodede vira med tykke skaller ... infection has an unexpected up side, at least in mice, since it protects them against bacterial infections..." ... Hantaviral Proteins: Structure, Functions, and Role in Hantavirus Infection. Frontiers in Microbiology ...
Infection prevention and control during health care for probable or confirmed cases of novel coronavirus (nCoV) infection (PDF) ... 腺病毒科 Adenoviridae. *乳头瘤病毒科 Papillomaviridae ... Camel infection 'led to Mers death'. BBC News. 2014-06-05 [2014 ... WHO: Novel coronavirus infection. 2013-02-11 [2013-02-13].. *^ James Gallagher. Coronavirus: Signs the new Sars-like virus can ... a person with a fever, respiratory infection, and evidence of pneumonia or acute respiratory distress syndrome. and. testing ...
This method can be used on plants that are not susceptible to Agrobacterium infection and also allows transformation of plant ... DNA-based viral vectors include Adenoviridae, adeno-associated virus and herpes simplex virus. Several of the methods used to ...
... not against infection; HIV infection may remain latent for long periods before causing AIDS. Most effective vaccines are whole- ... Find an HIV testing site near you Potential HIV vaccine using adenoviridae vectors Bit by Bit, Scientists Gain Ground on AIDS ... After three years, the vaccine group had HIV infection rates reduced by about 30% compared with those in the placebo group. ... The study involved 16,395 participants who did not have HIV infection, 8197 of whom were given treatment consisting of two ...
... not against infection; HIV infection may remain latent for long periods before causing AIDS.[citation needed] Most effective ... Find an HIV testing site near you Potential HIV vaccine using adenoviridae vectors [1]. ... However, after taking into account the seven people who had HIV infections at the time of their vaccination (two in the placebo ... After three years, the vaccine group saw HIV infection rates reduced by more than 30% compared with those in the placebo group ...
Hepatis B Virus (HBV) was identified as an infection distinct from Hepatitis A through its contamination of measles, mumps, and ... Diseases associated with this family include: liver infections, such as hepatitis, hepatocellular carcinomas (chronic ... nonenveloped: Adenoviridae. *Papillomaviridae. *Papovaviridae (obsolete). *Polyomaviridae. *genera: Rhizidiovirus. * ... cell to infect others or are immediately dismantled so the new viral genomes can enter the nucleus and magnify the infection. ...
Feline leukemia virus and Feline immunodeficiency virus infections are treated with biologics, including the only ... At that point, the infection will persist indefinitely. In most viruses, DNA is transcribed into RNA, and then RNA is ... As a result, cells such as neurons are very resistant to infection and transduction by retroviruses. This gives rise to a ... Antiretroviral drugs are medications for the treatment of infection by retroviruses, primarily HIV. Different classes of ...
But, unlike other viral infections, the incidence of polio - the rarer severe form of the infection - increased in the 20th ... Many bacteriologists soon discovered the cause of numerous infections. However, some infections remained, many of them ... Ivanovsky suggested the infection might be caused by a toxin produced by bacteria, but did not pursue the idea.[3] ... Infections by poliovirus most often cause the mildest of symptoms. This was not known until the virus was isolated in cultured ...
chronic infection in adult, and acute viral disease in young salmonid fish.[1][2] ... nonenveloped: Adenoviridae. *Papillomaviridae. *Papovaviridae (obsolete). *Polyomaviridae. *genera: Rhizidiovirus. * ...
Adenoviridae: Adenovirus. *Arenavirus: Guanarito virus,[2] Junín virus,[2] Lassa fever virus,[2] Lujo virus,[3] Machupo virus[2 ... infections transmitted through blood transfusion". Wiad Parazytol. 57 (2), s. 77-81. PMID 21682090.. KB1 bakım: Birden fazla ad ... Review of the literature". Infection. 35 (4), s. 212-8. doi:10.1007/s15010-007-6006-2. PMID 17646920.. KB1 bakım: Birden fazla ... Naides SJ (May 1998). "Rheumatic manifestations of parvovirus B19 infection". Rheum. Dis. Clin. North Am. 24 (2), s. 375-401. ...
Other common fungal infections include infections by the yeast strain Candida albicans. Candida can cause infections of the ... Pathogenic viruses are mainly from the families: Adenoviridae, Coronaviridae, Picornaviridae, Herpesviridae, Hepadnaviridae, ... For example, infection of mesenteric lymph glands of mice with Yersinia can clear the way for continuing infection of these ... Fungal infections such as athlete's foot, jock itch, and ringworm are infections of the skin and can be treated with topical ...
Without the virus infection, phagocytic hemocytes (blood cells) will encapsulate and kill the wasp egg and larvae but the ... The infection does not lead to replication of new viruses, rather it affects the caterpillar's immune system. ... nonenveloped: Adenoviridae. *Papillomaviridae. *Papovaviridae (obsolete). *Polyomaviridae. *genera: Rhizidiovirus. * ...
Common infections in humans caused by members of this order include cold sores, genital herpes, chickenpox, shingles, and ... nonenveloped: Adenoviridae. *Papillomaviridae. *Papovaviridae (obsolete). *Polyomaviridae. *genera: Rhizidiovirus. * ...
The gammaherpesviruses, including HVS, EBV, KSHV, and RRV, are capable of establishing latent infection in lymphocytes.[9] ... Ackermann, M. (2006). "Pathogenesis of gammaherpesvirus infections". Veterinary Microbiology. 113 (3-4): 211-222. doi:10.1016/j ... Viruses that establish lifelong latent infections must ensure that the viral genome is maintained within the latently infected ... Attenuated virus mutants represent a promising approach towards gamma-herpesvirus infection control. Surprisingly, latency- ...
What is Adenoviridae infections? Meaning of Adenoviridae infections medical term. What does Adenoviridae infections mean? ... Looking for online definition of Adenoviridae infections in the Medical Dictionary? Adenoviridae infections explanation free. ... Adenoviridae. (redirected from Adenoviridae infections). Also found in: Encyclopedia. Ad·e·no·vi·ri·dae. (adĕ-nō-viri-dē), A ... Adenoviridae infections , definition of Adenoviridae infections by Medical dictionary https://medical-dictionary. ...
Learn more about viral infections and their symptoms. ... Viruses cause familiar infections such as the common cold, but ... ClinicalTrials.gov: Adenoviridae Infections (National Institutes of Health) * ClinicalTrials.gov: Coxsackievirus Infections ( ... Antibiotics do not work for viral infections. There are antiviral medicines to treat some viral infections. Vaccines can help ... Viral Infections: How Do They Differ? (Mayo Foundation for Medical Education and Research) Also in Spanish ...
DNA Virus Infections. Virus Diseases. Adenoviridae Infections. Carcinoma. Carcinoma, Hepatocellular. Neoplasms, Glandular and ... Any active clinically serious infections (, grade 2 NCI-CTCAE ver 3.0). *HIV infection or AIDS-related illness or serious acute ...
Infection. Communicable Diseases. Adenoviridae Infections. DNA Virus Infections. Virus Diseases. To Top ... After receiving a cord blood transplant, they are at risk of infections until a new immune system to fight infections grows ... after a viral infection in the post-transplant period. In this study we are trying to prevent or treat viral infections by ... can prevent patients from getting an infection. EBV, AdV and CMV are viruses that can cause serious life-threatening infections ...
Expanded Access Protocol to Provide Brincidofovir for the Treatment of Serious Adenovirus Infection or Disease. The safety and ... Confirmed serious AdV infection based on clinical symptoms and laboratory testing showing AdV in the blood or other bodily ... An Intermediate-size, Expanded Access Protocol to Provide Brincidofovir for the Treatment of Serious Adenovirus Infection or ... Provide patients with serious AdV infection or disease access to treatment with BCV. ...
Infection. Communicable Diseases. Adenoviridae Infections. DNA Virus Infections. Virus Diseases. To Top ... for the treatment of AdV infection detected during asymptomatic AdV viremia or during symptomatic AdV infection. After ... in the Treatment of Early Versus Late Adenovirus Infection (CMX001 Adv). The safety and scientific validity of this study is ... AdV infection to the mortality at Week 24 for subjects treated with BCV during symptomatic or late AdV disease [ Time Frame: ...
5. Acute upper respiratory infection. 6. Addiction. 7. Adenoiditis. 8. Adenoviridae Infections. 9. Adenovirus infection in ...
Adenoviridae Infections / drug therapy * Adenoviridae Infections / metabolism * Adenoviridae Infections / virology * ... provide insight into the mechanism of AdV uncoating and suggest new strategies to disrupt this process and inhibit infection. ... and thereby blocks subsequent steps in uncoating that are required for release of protein VI and endosomalysis during infection ...
Adenoviridae Infections / complications* * Adenoviridae Infections / diagnostic imaging * Adenoviridae Infections / immunology ... four showed no discernible cause of bronchiectasis other than the antecedent type 7 adenoviral infection. The other two ...
5. Acute upper respiratory infection. 6. Addiction. 7. Adenoiditis. 8. Adenoviridae Infections. 9. Adenovirus infection in ...
RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and ... HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE ... PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.. Meningitis, ...
RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and ... HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal ... RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS. ...
Diseases : Adenoviridae Infections. Pharmacological Actions : Antiviral Agents. [+] Black tea extract has the potential to be ... Honey and green/black tea intake is associated with a reduced prevalence of H. pylori infections.Mar 05, 2015. ... Theaflavin digallate has potential to be a promising natural and affordable remedy against herpes simplex viral infections.May ... Gargling with tea and its ingredients may have a preventative effect for influenza infection. Dec 31, 2015. ...
These diseases associated with adenovirus infection affect adults and are usually more severe in infant ... Adenoviridae / isolation & purification*. Adenoviridae Infections / veterinary*, virology. Age Distribution. Animals. ... To date, limited studies have been done to determine the prevalence of adenovirus infection in non-human primates with the goal ... CONCLUSION: The results of this study indicate that adenovirus infection is prevalent among non-human primates in Kenya. These ...
HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary ... Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection. Cell. 2018 02 22; 172(5):952-965.e18. ... Alzheimers Disease-Associated ß-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection. Neuron. 2018 07 ...
Adenoviridae Infections Global Clinical Tr ... $ 2500 October 2018 Colitis - Pipeline Review, H1 2019 $ 2000 February 2019 ...
Categories: Adenoviridae Infections Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Adenoviridae Infections ... headache*Adenovirus infection in immunocompromised patients ... headache*Adenovirus-related Cold ... Bartonella infections ... headache*Bartonellosis ... headache*Bartonellosis due to Bartonella quintana infection ... headache* ... Campylobacter jejuni infection ... headache*Campylobacter laridis infection ... headache*Camurati Engelmann disease, type 2 ... Acanthamoeba infection ... headache*Acanthamoeba infection of the central nervous system ... headache*Acanthocheilonemiasis ...
Adenoviridae Infections. 8932367. Monomeric scAlu and nascent dimeric Alu RNAs induced by adenovirus are assembled into SRP9/14 ...
Adenophorea Infections ... cough*Adenosine triphosphatase deficiency, anaemia due to ... breathlessness*Adenoviridae Infections ... Arcobacter butzleri infection ... vomiting*Arcobacter cryaerophilus infection ... vomiting*Arcobacter infection ... vomiting* ... Acanthamoeba infection ... vomiting*Acanthamoeba infection of the central nervous system ... vomiting*Acanthocytosis ... ... Aspiration lung infection (10 causes), Acute AIDS-like recurring respiratory infections (5 causes), Chronic bronchitis (19 ...
b. Adenoviruses belong to the family Adenoviridae and have been isolated from humans and animals. 2. Infections a. Respiratory ... b. Acute infections produce symptoms resembling HAV infections. c. Chronic infections are common and can result in cirrhosis ... a. Skin infections: Rash site and, depending on the virus, serum and urine b. Respiratory infections: Sputum or throat swabs c ... 2. Infections a. Infections are spread by the fecal-oral route and are generally due to poor sanitation and hygiene. Food ...
A method of inhibiting viral infection in a mammal in need of same, includes administering an effective amount of at least one ... 1. Adenoviridae. Adenovirus. Naked. Icosahedral. ds. 2. Papovaviridae. Papillomavirus. Naked. Icosahedral. ds circular. ... for administration to a human or animal experiencing a viral infection or at risk of a viral infection. Such pharmaceutical ... The infection pathway and timing of RSV is well known, and is set forth in the lower right corner. As can be seen, at any time ...
Humans; Animals; *Adenoviridae/classification; Adenoviridae Infections/*etiology/*transmission; Chiroptera/*virology; Disease ...
The Adenoviridae Virus Family: Infections of Head, Chest & Abdomen 7:18 * Liver Cancer and Hepatitis B: Hepadnaviridae ...
208000010370 Adenoviridae Infections Diseases 0 description 1 * 206010060931 Adenovirus infection Diseases 0 description 1 ... Susceptible chickens less than 3 weeks old do not exhibit outward clinical signs of the disease but have a marked infection ... In the past, control of IBDV infection in young chickens has been achieved by live vaccination with avirulent strains, or ... when the embryo is highly susceptible to infection. ... direct microinjection and adenovirus infection.. The most ...
R. Wigand, A. Bartha, R. S. Dreizin et al., "Adenoviridae: second report," Intervirology, vol. 18, pp. 169-176, 1982. View at ... infection are those reported by Okuyan [18] and Gür and Acar [16]. The antibody prevalence of the infection is reported to vary ... are not able to be protected against CAV infection when exposed, and mortalities may occur. Clinical ICH infection is more ... I. Virus Infections of Carnivores, M. C. Horzinek, Ed., pp. 29-43, Elsevier Science, Amsterdam, The Netherlands, 1987. View at ...
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Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 ... Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 ... Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 ... Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 ...
Mulrooney, D. A., Dover, D. C., Li, S., Yasui, Y., Ness, K. K., Mertens, A. C., Neglia, J. P., Sklar, C. A., Robison, L. L., Davies, S. M., Hudson, M., Armstrong, G., Perkins, J., OLeary, M., Friedman, D., Pendergrass, T., Greffe, B., Odom, L., Ruccione, K., Mulvihill, J. & 30 others, Ginsberg, J., Meadows, A., Tersak, J., Ritchey, A. K., Blatt, J., Reaman, G., Packer, R., Davies, S., Bhatia, S., Qualman, S., Hammond, S., Termuhlen, A., Ruymann, F., Diller, L., Grier, H., Li, F., Meacham, L., Mertens, A., Leisenring, W., Potter, J., Greenberg, M., Nathan, P. C., Boice, J., Rodriguez, V., Smithson, W. A., Gilchrist, G., Oeffinger, K., Finklestein, J., Anderson, B. & Inskip, P., May 1 2008, In : Cancer. 112, 9, p. 2071-2079 9 p.. Research output: Contribution to journal › Article ...
  • Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT patients, 18 of whom had severe manifestations of infection. (northwestern.edu)
  • There were no significant differences in the association of bacterial or parasitic infections with either enteric or nonenteric adenovirus infections in either group of children studied. (umassmed.edu)
  • A single institution case series of adenovirus infections after allogeneic hematopoietic stem cell transplantation is presented to highlight the consideration for adenovirus infections as an etiology in patients with rapid hepatic or other sudden organ deterioration in the setting of apparent GVHD stabilization. (elsevier.com)
  • Adenovirus infections also have the additional challenge that its treatment, cidofovir, has associated toxicities that can delay its administration. (elsevier.com)
  • No therapeutic agent has yet been established as the definitive therapy for adenovirus infections. (elsevier.com)
  • Adenovirus infections mimic bacterial infections on initial presentation in healthy children, leading to higher likelihood of hospital admission. (uthscsa.edu)
  • Acute respiratory disease (ARD), first recognized among military recruits during World War II, can be caused by adenovirus infections during conditions of crowding and stress. (barlowminerals.com)
  • 1][2] Diagnosis Antigen detection, polymerase chain reaction assay, virus isolation, and serology can be used to identify adenovirus infections. (barlowminerals.com)
  • These cells will try to fight viruses that can cause infection. (clinicaltrials.gov)
  • EBV, AdV and CMV are viruses that can cause serious life-threatening infections in patients who have weak immune systems after transplant. (clinicaltrials.gov)
  • Most chest infections are due to viruses or bacteria but fungi and even protozoa (single-celled parasites) can also be responsible. (healthhype.com)
  • Although common viral infections like the flu may cause a mild chest infection, some viruses can cause severe and even deadly chest infections. (healthhype.com)
  • It is important to note that this is not a complete list of all the possible bacteria and viruses that may cause a chest infection. (healthhype.com)
  • Some uncommon viruses and bacteria may also cause rare chest infections. (healthhype.com)
  • The extent to which viruses infect targeted cells determines the efficacy of this approach but many tumors down-regulate the Coxsackievirus and Adenovirus Receptor (CAR), rendering them less susceptible to infection. (nih.gov)
  • Adenoviruses (members of the family Adenoviridae) are medium-sized (90-100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome. (wikipedia.org)
  • Currently, there are approximately 200 known respiratory viruses that can be grouped into one family of DNA viruses (Adenoviridae) and four families of RNA viruses (Orthomyxoviridae, Paramyxoviridae, Picornaviridae and Coronaviridae). (nih.gov)
  • CINAHL 2007 - 7/1/2009 [exp Bronchiolitis OR Bronchiolit$ OR Bronchiolitis, viral OR exp Respiratory syncitial viruses/ OR Respiratory syncitial vir$ OR exp Paramyxoviridae infections OR exp Respirovirus infections/ OR exp Influenza, Human/ OR exp Adenoviridae] AND [exp saline solution, hypertonic/ OR hypertonic saline.mp. (bestbets.org)
  • The presence of some viruses could lead to "long-term infections that may be associated with increased risk or possibly with protection from disease,'' the study stated, but the findings should not be cause for alarm. (boston.com)
  • Researchers found that many of the viruses came from latent infections from years ago, while many subjects had low-level infections. (boston.com)
  • Adenovirus 5 belongs to Adenoviridae, a family of viruses with at least 51 serotypes that cause a variety of illnesses, mostly being upper respiratory tract infections. (mybiosource.com)
  • Adenoviridae are dsDNA viruses and are the largest non-enveloped viruses. (mybiosource.com)
  • How to prevent gout experience of irritants, pollutants or due to infection along with viruses or even bacteria, the particular bronchial region becomes inflamed, resulting in overproduction and expectoration of mucus. (myartsonline.com)
  • Most respiratory viruses cause localised infections: replication and shedding of virus remains confined to the respiratory tract. (uct.ac.za)
  • AD-36 infection can induce cellular differentiation of 3T3-L1 preadipocytes and stem cells derived from human adipose tissue Adenoviridae Adenoviruses are medium-sized (90-100 nm), nonenveloped (naked) icosahedral viruses composed of a nucleocapsid and a double-stranded linear DNA genome. (barlowminerals.com)
  • Viruses of the family Adenoviridae infect various species of vertebrates, including humans. (barlowminerals.com)
  • Human adenoviruses (HAdVs) can cause a wide spectrum of clinical illness, ranging from asymptomatic infections to severe illnesses and death. (cdc.gov)
  • Human adenoviruses (Ads) are associated with a significant number of gastrointestinal and respiratory infections in young children and are also a leading cause of viral conjunctivitis. (asm.org)
  • Fully revised and updated by the new author team, partI presents the fundamental principles of virology related to animal infection and disease, and partII addresses the clinical features, pathogenesis, diagnosis, epidemiology and prevention of individual diseases. (barnesandnoble.com)
  • Viral infecciones are the main etiology, and adenovirus infección clould lead to severe disease, with cross infections. (bvsalud.org)
  • By comparison, 19.7% of children with gastroenteritis and 0.7% of those without gastroenteritis were positive for rotavirus infection. (umassmed.edu)
  • In the adenovirus-infected children with gastroenteritis, there were coinfections with rotavirus only in those with nonenteric adenovirus infection (7 of 27 children). (umassmed.edu)
  • Clinical manifestations associated with HAdV infection include fever, acute respiratory illness, gastroenteritis, and conjunctivitis. (cdc.gov)
  • Our study identifies three risk factors, namely, respiratory distress, wheezing and acute gastroenteritis, associated with hospital admission for healthy children with adenoviral infections. (uthscsa.edu)
  • Pharyngo-conjunctival fever (or swimming pool fever) is one of the better known, but also gastroenteritis , upper respiratory tract infections and pneumonia can all occur. (healthtap.com)
  • It (different serotype) occasionally causes eye infection (acute hemorrhagic conjunctivitis ) and gastroenteritis . (healthtap.com)
  • Gargling with tea and its ingredients may have a preventative effect for influenza infection. (greenmedinfo.com)
  • The flu (seasonal influenza) is a viral infection that can affect the entire respiratory tract, from the nose all the way down to the lungs. (healthhype.com)
  • AVENDANO C, Luis F y LEVINE, Myron M . Systematic surveillance of influenza, syncytial respiratory, parainfluenza and adenovirus in children with acute respiratory infections . (scielo.cl)
  • This surveillance model is effective for the detection of influenza and other virus responsible for acute respiratory infections and their relationship with the demand for health care during the cold months. (scielo.cl)
  • Journal of Microbiology, Immunology and Infection. (elsevier.com)
  • Infection and Immunity. (elsevier.com)
  • Construction and Characterizations of Bordetella pertussis Toxin Mutants," Infection & Immunity 55(10):2465-2470 (1987). (patentgenius.com)
  • Therefore a chest infection should be understood to refer to a lower respiratory tract infection (tracheitis and/or bronchitis) and/or pneumonia (lungs). (healthhype.com)
  • Approximately 5% of upper respiratory tract infections In southern Taiwan, a shift from Ad7a to Ad7b was report- and 8% of childhood pneumonia cases are attributed ed from 1983 to 2000 (12). (cdc.gov)
  • Respiratory viral infections (RVIs) can be associated with a wide range of clinical manifestations ranging from self-limited upper respiratory tract infections to more devastating conditions, such as pneumonia. (nih.gov)
  • The "normal viral flora'' found stems from seven families: Herpesviridae, Polyomaviridae, Papillomaviridae, Adenoviridae (common cold and pneumonia causing), Anelloviridae, Parvoviridae and Circoviridae. (boston.com)
  • Correction: A previous version of this article said that Adenoviridae is a virus that causes the flu and pneumonia. (boston.com)
  • Adenoviridae is a virus that causes the common cold and pneumonia. (boston.com)
  • The respiratory tract is also commonly a target in generalised viral infections: for example, pneumonia may complicate infection caused by measles, varicella and cytomegalovirus. (uct.ac.za)
  • Symptoms of respiratory illness caused by adenovirus infection range from the common cold syndrome to pneumonia, croup, and bronchitis. (barlowminerals.com)
  • 2010. Differential specificity and immunogenicity of adenovirus type 5 neutralizing antibodies elicited by natural infection or immunization. . (fredhutch.org)
  • Frontiers in Cellular and Infection Microbiology. (utmb.edu)
  • CAV-1 replicates in vascular endothelial cells and causes a generalized infection characterized by hepatitis [ 7 ], whereas CAV-2 has an affinity for respiratory tract epithelium and is mainly associated with outbreaks of respiratory disease in kenneled dogs [ 8 ]. (hindawi.com)
  • In contrast to that observed in endothelial cells, the Ad vector-mediated induction of gene expression was not found following Ad vector infection of primary human dermal fibroblasts or human alveolar macrophages. (elsevier.com)
  • Confluent necrotizing hepatitis secondary to adenovirus infection alone or together with other organ involvement is extremely rare. (northwestern.edu)
  • These methods may form part of a method of preventing or treating hepatitis B infection. (freepatentsonline.com)
  • Bacterial infections leading to gonococcal and non-gonococcal urethritis can be prevented by: sexual abstinence use of barrier contraception, such as condoms pre-exposure vaccination: HPV and Hepatitis B vaccines reducing number of sexual partners Chlorhexidine is an antibacterial agent that covers a wide spectrum of gram-positive and gram-negative bacteria. (wikipedia.org)
  • Three acyclic nucleoside phosphonates (ANPs) have been formally approved for clinical use in the treatment of 1) cytomegalovirus retinitis in AIDS patients (cidofovir, by the intravenous route), 2) chronic hepatitis B virus (HBV) infections (adefovir dipivoxil, by the oral route), and 3) human immunodeficiency virus (HIV) infections (tenofovir disoproxil fumarate, by the oral route). (unboundmedicine.com)
  • CAVs belong to the genus Mastadenovirus of the family Adenoviridae. (hindawi.com)
  • Confirmation of diagnosis and identification of CAV-1 and CAV-2 infections are usually based on virus isolation, electron-microscopic observation and serological tests [ 14 ]. (hindawi.com)
  • Compared to the late infection group, patients with early infection had significantly lower absolute lymphocyte counts at week 1 (p = 0.01) and 3 (p = 0.002) after diagnosis. (elsevier.com)
  • Diagnosis of this viral infection can be accomplished using culture or serological methods. (zoologix.com)
  • The Diagnosis of Virus Infections 6. (barnesandnoble.com)
  • Despite this, almost all serious respiratory infections are treated with antibiotics and a 'presumed viral' diagnosis is only made when the patient fails to respond. (uct.ac.za)
  • A fixed-ratio combination of amoxicillin trihydrate (see AMOXICILLIN), an aminopenicillin, and potassium clavulanate (see CLAVULANIC ACID), a beta-lactamase inhibitor, used to treat a broad-spectrum of bacterial infections, especially resistant strains. (bioportfolio.com)
  • Bacterial infections are usually secondary to viral infection of the nose and pharynx. (uct.ac.za)
  • in humans, more than 50 distinct adenoviral serotypes have been found to cause a wide range of illnesses, from mild respiratory infections in young children (known as the common cold) to life-threatening multi-organ disease in people with a weakened immune system. (wikipedia.org)
  • Provide patients with serious AdV infection or disease access to treatment with BCV. (clinicaltrials.gov)
  • However, only three (27.3%) patients with early infection developed disease progression. (elsevier.com)
  • This study reports on the characteristics and outcome of adenovirus disease among kidney recipients and shows that prompt reduction of immunosuppression and close monitoring of blood viral load are useful, particularly in high-risk patients with infection early post-transplantation. (elsevier.com)
  • Studies of considerable sample size are required to determine robust Cycle threshold cut-off values to effectively correlate infection to disease. (unipa.it)
  • 6] Strict attention to good infection-control practices is effective for stopping nosocomial outbreaks of adenovirus-associated disease, such as epidemic keratoconjunctivitis. (barlowminerals.com)
  • Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 patients. (northwestern.edu)
  • In vivo, HPMPO-DAPy proved equipotent to cidofovir in suppressing vaccinia virus infection (tail lesion formation) in immunocompetent mice and promoting healing of disseminated vaccinia lesions in athymic-nude mice. (unboundmedicine.com)
  • This is particularly true for adenoviral infections as they also have a distinct clinical picture in immunocompromised patients when compared to immune competent patients. (elsevier.com)
  • This is a multicenter study of Brincidofovir ( CMX001 ) (BCV) administered twice weekly (BIW) for the treatment of AdV infection detected during asymptomatic AdV viremia or during symptomatic AdV infection. (clinicaltrials.gov)
  • infection is mainly asymptomatic in most cases Adenoviridae Uropathogenic Escherichia coli (UPEC) Herpes simplex virus Cytomegalovirus Reactive arthritis: urethritis is part of the triad of reactive arthritis, which includes arthritis, urethritis, and conjunctivitis. (wikipedia.org)
  • This study will compare the efficacy, safety and tolerability of intravenous ertapenem versus another intravenous antibiotic in the treatment of moderate to severe diabetic foot infection. (bioportfolio.com)
  • These diseases associated with adenovirus infection affect adults and are usually more severe in infants and children. (biomedsearch.com)
  • However, most people with healthy immune systems do not have a severe lower respiratory tract infection with the flu. (healthhype.com)
  • This does not mean that every severe chest infection in people who are immune compromised will lead to fatal outcomes. (healthhype.com)
  • As a general rule, every chest infection even in healthy individuals should be assessed and treated by a medical professional, particularly if it is severe, persisting or worsening. (healthhype.com)
  • In severe or prolonged infections there may also be symptoms like unintentional weight loss. (healthhype.com)
  • It is often thought that bacterial chest infections are more severe. (healthhype.com)
  • However, in infants and young children, URT infections may spread downwards and cause more severe, sometimes life threatening infections. (uct.ac.za)
  • Patients with compromised immune systems are especially susceptible to severe complications of adenovirus infection. (barlowminerals.com)
  • Adenovirus infection most often involves upper respiratory tract causing common cold and sore throat ( pharyngitis or tonsillitis ). (healthtap.com)
  • type species: Frog siadenovirus A Classification of Adenoviridae can be complex. (wikipedia.org)
  • Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection. (harvard.edu)
  • AD-36 was first isolated in 1978 from the feces of a girl suffering from diabetes and enteritis,[1] and has long been recognized as a cause of respiratory and eye infections in humans. (barlowminerals.com)
  • There are 53 described serotypes in humans, which are responsible for 5-10% of upper respiratory infections in children, and many infections in adults as well. (barlowminerals.com)
  • Intracellular Delivery of Cytolytic T-Lymphocyte Epitope Peptide by Pertussis Toxin to Major Histocompatibility Complex Class I Without Involvement of the Cytosolic Class I Antigen Processing Pathway," Infection & Immunity67(2):602-607 (1999). (patentgenius.com)
  • For example, elderly people are at a greater risk of serious complications and even death from a chest infection, as are people who have a weakened immune system such as people with AIDS or those on certain immune-suppressing treatments. (healthhype.com)
  • Because there is no virus-specific therapy, serious adenovirus illness can be managed only by treating symptoms and complications of the infection. (barlowminerals.com)
  • Since 1996 and during the cold months (May to September), 20 samples of upper respiratory secretions per week, were obtained from children with acute respiratory infections consulting to the emergency room of a public hospital. (scielo.cl)
  • The weekly number of consultations in the emergency room and the number of hospital discharges due to acute respiratory infections, were registered. (scielo.cl)
  • The hospital discharges due to acute respiratory infections paralleled the syncytial respiratory virus detection rates. (scielo.cl)
  • To date, limited studies have been done to determine the prevalence of adenovirus infection in non-human primates with the goal of developing a non-human primate model that can be used to study the mechanisms of infection. (biomedsearch.com)
  • OBJECTIVE: To determine the prevalence of enteric adenovirus infection in Kenyan non-human primates. (biomedsearch.com)
  • DESIGN: A prospective study to investigate the prevalence of enteric andenovirus infection in captive non-human primates maintained in a colony. (biomedsearch.com)
  • CONCLUSION: The results of this study indicate that adenovirus infection is prevalent among non-human primates in Kenya. (biomedsearch.com)
  • 60 genotypes are known to cause human infection ( 1 ). (cdc.gov)
  • Ad serotype 37 (Ad37), a virus associated with epidemic keratoconjunctivitis, but not a closely related virus serotype, Ad19p, exhibited preferential binding to and infection of human conjunctival cells. (asm.org)
  • Japan from 1987 to 1992, and Ad7d2 was the major restricted to the upper respiratory tract, but infection can genome type isolated during a large Japanese outbreak sometimes develop in the lower tract or at other distal from 1995 to 1998 (13). (cdc.gov)
  • For most viral infections, treatments can only help with symptoms while you wait for your immune system to fight off the virus. (medlineplus.gov)
  • Infection of swine with this virus usually produces very mild or subclinical symptoms. (zoologix.com)
  • For infectious causes of urethritis, symptoms may start a few weeks to several months after infection. (wikipedia.org)
  • Non-gonococcal urethritis typically does not have noticeable symptoms in women, however, the infection can spread to parts of the female reproductive system. (wikipedia.org)
  • What are symptoms of adenovirus infection? (healthtap.com)
  • Does adenovirus infection usually cause many symptoms? (healthtap.com)
  • Aiello, LF & Luby, JP 1974, ' Concomitant Mycoplasma and Adenovirus Infection in a Family ', American Journal of Diseases of Children , vol. 128, no. 6, pp. 874-877. (elsevier.com)
  • Porcine adenovirus is a double-stranded DNA virus belonging to the Adenoviridae family. (zoologix.com)
  • The purpose of this study is to demonstrate that MK0826 is comparable to Meropenem in the treatment of complicated Urinary Tract Infections (UTIs) in adults. (bioportfolio.com)
  • Infections of the respiratory tract are very common in both adults and children. (uct.ac.za)
  • Another study showed that copper surfaces in a hospitals killed 97% of the ICU bacteria that can cause infection, which resulted in a 40% reduction in infection rates. (blogspot.com)
  • It is a commonly treatable condition usually caused by infection with bacteria. (wikipedia.org)
  • Information on the clinical spectrum and management of adenovirus infection after kidney transplantation is limited. (elsevier.com)
  • It is therefore not a chest infection although secondary infections can follow the cold and affect the trachea, bronchi and/or lungs. (healthhype.com)
  • In these cases the secondary infection would be referred to as a chest infection. (healthhype.com)