Adenoviridae Infections: Virus diseases caused by the ADENOVIRIDAE.Adenoviridae: A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Pediatrics: A medical specialty concerned with maintaining health and providing medical care to children from birth to adolescence.Infant, Newborn: An infant during the first month after birth.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Area Under Curve: A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)Half-Life: The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.Child Welfare: Organized efforts by communities or organizations to improve the health and well-being of the child.AIDS Vaccines: Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.Pregnancy Tests: Tests to determine whether or not an individual is pregnant.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Vaccination: Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.Vaccines: Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.Leukapheresis: The preparation of leukocyte concentrates with the return of red cells and leukocyte-poor plasma to the donor.Pregnancy Tests, Immunologic: Methods of detecting pregnancy by examining the levels of human chorionic gonadotropin (HCG) in plasma or urine.Contraception: Prevention of CONCEPTION by blocking fertility temporarily, or permanently (STERILIZATION, REPRODUCTIVE). Common means of reversible contraception include NATURAL FAMILY PLANNING METHODS; CONTRACEPTIVE AGENTS; or CONTRACEPTIVE DEVICES.Chorionic Gonadotropin, beta Subunit, Human: The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.Contraception Behavior: Behavior patterns of those practicing CONTRACEPTION.Pregnancy, Ectopic: A potentially life-threatening condition in which EMBRYO IMPLANTATION occurs outside the cavity of the UTERUS. Most ectopic pregnancies (>96%) occur in the FALLOPIAN TUBES, known as TUBAL PREGNANCY. They can be in other locations, such as UTERINE CERVIX; OVARY; and abdominal cavity (PREGNANCY, ABDOMINAL).Contraceptive Agents: Chemical substances that prevent or reduce the probability of CONCEPTION.Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Glycogen Storage Disease Type V: Glycogenosis due to muscle phosphorylase deficiency. Characterized by painful cramps following sustained exercise.Diagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Rhabdomyolysis: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.Status Asthmaticus: A sudden intense and continuous aggravation of a state of asthma, marked by dyspnea to the point of exhaustion and collapse and not responding to the usual therapeutic efforts.Depression: Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.Nose: A part of the upper respiratory tract. It contains the organ of SMELL. The term includes the external nose, the nasal cavity, and the PARANASAL SINUSES.Intestinal Diseases: Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.Cellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.Mouth: The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Affective Symptoms: Mood or emotional responses dissonant with or inappropriate to the behavior and/or stimulus.Autonomic Nervous System Diseases: Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.Somatoform Disorders: Disorders having the presence of physical symptoms that suggest a general medical condition but that are not fully explained by a another medical condition, by the direct effects of a substance, or by another mental disorder. The symptoms must cause clinically significant distress or impairment in social, occupational, or other areas of functioning. In contrast to FACTITIOUS DISORDERS and MALINGERING, the physical symptoms are not under voluntary control. (APA, DSM-V)Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.Calcaneus: The largest of the TARSAL BONES which is situated at the lower and back part of the FOOT, forming the HEEL.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.ConjunctivitisErythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Common Cold: A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.Hematologic Diseases: Disorders of the blood and blood forming tissues.Herpesvirus 4, Human: The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.Epstein-Barr Virus Infections: Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).Adenoviruses, Human: Species of the genus MASTADENOVIRUS, causing a wide range of diseases in humans. Infections are mostly asymptomatic, but can be associated with diseases of the respiratory, ocular, and gastrointestinal systems. Serotypes (named with Arabic numbers) have been grouped into species designated Human adenovirus A-F.Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.Polyomavirus Infections: Infections with POLYOMAVIRUS, which are often cultured from the urine of kidney transplant patients. Excretion of BK VIRUS is associated with ureteral strictures and CYSTITIS, and that of JC VIRUS with progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL).Flatulence: Production or presence of gas in the gastrointestinal tract which may be expelled through the anus.Institutionalization: The caring for individuals in institutions and their adaptation to routines characteristic of the institutional environment, and/or their loss of adaptation to life outside the institution.Heartburn: Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Diagnostic Techniques and Procedures: Methods, procedures, and tests performed to diagnose disease, disordered function, or disability.Abbreviations as Topic: Shortened forms of written words or phrases used for brevity.Digestive System: A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).

Adenoviral gene transfer of the human V2 vasopressin receptor improves contractile force of rat cardiomyocytes. (1/761)

BACKGROUND: In congestive heart failure, high systemic levels of the hormone arginine vasopressin (AVP) result in vasoconstriction and reduced cardiac contractility. These effects are mediated by the V1 vasopressin receptor (V1R) coupled to phospholipase C beta-isoforms. The V2 vasopressin receptor (V2R), which promotes activation of the Gs/adenylyl cyclase system, is physiologically expressed in the kidney but not in the myocardium. Expression of a recombinant V2R (rV2R) in the myocardium could result in a positive inotropic effect via the endogenous high concentrations of AVP in heart failure. METHODS AND RESULTS: A recombinant adenovirus encoding the human V2R (Ad-V2R) was tested for its ability to modulate the cardiac Gs/adenylyl cyclase system and to potentiate contractile force in rat ventricular cardiomyocytes and in H9c2 cardiomyoblasts. Ad-V2R infection resulted in a virus concentration-dependent expression of the transgene and led to a marked increase in cAMP formation in rV2R-expressing cardiomyocytes after exposure to AVP. Single-cell shortening measurements showed a significant agonist-induced contraction amplitude enhancement, which was blocked by the V2R antagonist, SR 121463A. Pretreatment of Ad-V2R-infected cardiomyocytes with AVP led to desensitization of the rV2R after short-term agonist exposure but did not lead to further loss of receptor function or density after long-term agonist incubation, thus demonstrating resistance of the rV2R to downregulation. CONCLUSIONS: Adenoviral gene transfer of the V2R in cardiomyocytes can modulate the endogenous adenylyl cyclase-signal transduction cascade and can potentiate contraction amplitude in cardiomyocytes. Heterologous expression of cAMP-forming receptors in the myocardium could lead to novel strategies in congestive heart failure by bypassing the desensitized beta-adrenergic receptor signaling.  (+info)

A single amino acid in the adenovirus type 37 fiber confers binding to human conjunctival cells. (2/761)

A 46-kDa receptor, coxsackievirus-adenovirus (Ad) receptor (CAR), mediates cell attachment of a number of different Ad serotypes; however, not all Ad serotypes utilize this receptor for infection. Moreover, the precise amino acid sequences in the Ad fiber protein that mediate cell attachment have yet to be identified. We investigated the interaction of subgroup D Ads with human ocular cells. Ad serotype 37 (Ad37), a virus associated with epidemic keratoconjunctivitis, but not a closely related virus serotype, Ad19p, exhibited preferential binding to and infection of human conjunctival cells. A single amino acid substitution in the Ad19p fiber distal domain (knob), Glu240 to Lys, conferred binding to conjunctival cells, while the reverse substitution in the Ad37 fiber abrogated cell binding. These findings provide new information on the fiber sequences that regulate Ad host cell tropism.  (+info)

Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction. (3/761)

BACKGROUND: The use of molecular biological techniques has demonstrated the importance of enteroviral infection of the myocardium in the pathogenesis of myocarditis and dilated cardiomyopathy in adults and adenovirus and enterovirus infection in children. The aim of this study was to determine the frequency of adenoviral infection of the myocardium of adults with impaired left ventricular function of unknown origin. METHODS AND RESULTS: Nested polymerase chain reaction (nPCR) was used to determine the frequency of detection of adenoviral DNA and enteroviral RNA in myocardial tissue samples from 94 adult patients with idiopathic left ventricular dysfunction and 14 control patients. Histological and immunohistological analyses were performed to detect myocardial inflammation. Adenoviral genomic DNA was detected by nPCR in 12 of the 94 patients with left ventricular dysfunction (in each case, adenovirus type 2), whereas enteroviral RNA was detected in another 12 patients. All control samples were negative for both viruses. In all patients, active myocarditis was excluded according to the Dallas criteria. However, there was significantly decreased CD2, CD3, and CD45RO T lymphocyte counts in the adenovirus-positive group compared with the adenovirus-negative group (P<0.05), whereas no differences were associated with enterovirus infection. CONCLUSIONS: Although enteroviruses are an important causative agent in the pathogenesis of myocarditis and dilated cardiomyopathy, this study shows that adenovirus infection is also important in the pathogenesis of left ventricular failure in adults. However, the pathogenetic basis of disease associated with adenovirus infection may be different than that after infection with other agents, particularly with respect to activation of the host immune response.  (+info)

Adenovirus infection after pediatric bone marrow transplantation. (4/761)

Retrospective analysis of 206 patients undergoing 215 consecutive bone marrow transplants (BMT) at St Jude Children's Research Hospital between November 1990 and December 1994 identified 6% (seven male, six female) with adenovirus infection. The affected patients had a median age of 7.9 years (range 3-24 years) at time of transplantation. Although transplants were performed for hematologic malignancies, solid tumors or nonmalignant conditions, only patients with hematologic malignancies had adenoviral infections. Adenovirus was first detected at a median of 54 days (range -4 to +333) after BMT. Adenovirus developed in eight of 69 (11.6%) patients receiving grafts from matched unrelated or mismatched related donors, in four of 52 (7.7%) receiving grafts from HLA-matched siblings, and in one of 93 (1.1%) receiving autografts. The most common manifestation of adenovirus infection was hemorrhagic cystitis, followed by gastroenteritis, pneumonitis and liver failure. The incidence of adenovirus infection in pediatric BMT patients at our institution is similar to that reported in adult patients. Using univariate analysis, use of total body irradiation and type of bone marrow graft were significant risk factors for adenovirus infection. Only use of total body irradiation remained as a factor on multiple logistic regression analysis.  (+info)

Lesions and transmission of experimental adenovirus hemorrhagic disease in black-tailed deer fawns. (5/761)

Adenovirus infection was the cause of an epizootic of hemorrhagic disease that is believed to have killed thousands of mule deer (Odocoileus hemionus) in California during the latter half of 1993. A systemic vasculitis with pulmonary edema and hemorrhagic enteropathy or a localized vasculitis associated with necrotizing stomatitis/pharyngitis/glossitis or osteomyelitis of the jaw were common necropsy findings in animals that died during this epizootic. To study transmission of adenovirus infection in deer and susceptibility of black-tailed deer (Odocoileus hemionus columbianus) fawns to adenovirus infection, six 3-6-month-old black-tailed fawns were divided into two treatment groups. One group was inoculated intravenously and the other group was inoculated through the mucous membranes of the eyes, nose and mouth with purified adenovirus. Each treatment group also included two additional fawns (four total) that were not inoculated but were exposed to inoculated animals (contact animals). One fawn served as a negative control. Between 4 and 16 days postinoculation, 8/10 fawns developed systemic or localized infection with lesions identical to lesions seen in animals with natural disease that died during the epizootic. Transmission was by direct contact, and the route of inoculation did not affect the incubation period or the distribution of the virus (systemic or the localized infection). Immunohistochemical analysis using polyclonal antiserum against bovine adenovirus type 5 demonstrated staining in endothelial cells of vessels in numerous tissues in animals with systemic infection and endothelial staining only in vessels subtending necrotic foci in the upper alimentary tract in animals with the localized form of the disease. All inoculated or exposed animals had staining in the tonsillar epithelium. Transmission electron microscopic examination of lung and ileum from two fawns with pulmonary edema and hemorrhagic enteropathy demonstrated endothelial necrosis and adenovirus virions in endothelial cell nuclei. Adenovirus was reisolated in black-tailed deer pulmonary artery endothelial cells using lung homogenate of the first fawn that developed systemic adenovirus infection. Serum virus neutralization test results suggest that this deer adenovirus is a new serotype.  (+info)

Gene transfer to human pancreatic endocrine cells using viral vectors. (6/761)

We have studied the factors that influence the efficiency of infection of human fetal and adult pancreatic endocrine cells with adenovirus, murine retrovirus, and lentivirus vectors all expressing the green fluorescent protein (Ad-GFP, MLV-GFP, and Lenti-GFP, respectively). Adenoviral but not retroviral vectors efficiently infected intact pancreatic islets and fetal islet-like cell clusters (ICCs) in suspension. When islets and ICCs were plated in monolayer culture, infection efficiency with all three viral vectors increased. Ad-GFP infected 90-95% of the cells, whereas infection with MLV-GFP and Lenti-GFP increased only slightly. Both exposure to hepatocyte growth factor/scatter factor (HGF/SF) and dispersion of the cells by removal from the culture dish and replating had substantial positive effects on the efficiency of infection with retroviral vectors. Studies of virus entry and cell replication revealed that cell dispersion and stimulation by HGF/SF may be acting through both mechanisms to increase the efficiency of retrovirus-mediated gene transfer. Although HGF/SF and cell dispersion increased the efficiency of infection with MLV-GFP, only rare cells with weak staining for insulin were infected, whereas approximately 25% of beta-cells were infected with Lenti-GFP. We conclude that adenovirus is the most potent vector for ex vivo overexpression of foreign genes in adult endocrine pancreatic cells and is the best vector for applications where high-level but transient expression is desired. Under the optimal conditions of cell dispersion plus HGF/SF, infection with MLV and lentiviral vectors is reasonably efficient and stable, but only lentiviral vectors efficiently infect pancreatic beta-cells.  (+info)

Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. (7/761)

To understand the function of specific proteins in sensory hair cells, it is necessary to add or inactivate those proteins in a system where their physiological effects can be studied. Unfortunately, the usefulness of heterologous expression systems for the study of many hair cell proteins is limited by the inherent difficulty of reconstituting the hair cell's exquisite cytoarchitecture. Expression of exogenous proteins within hair cells themselves may provide an alternative approach. Because recombinant viruses were efficient vectors for gene delivery in other systems, we screened three viral vectors for their ability to express exogenous genes in hair cells of organotypic cultures from mouse auditory and vestibular organs. We observed no expression of the genes for beta-galactosidase or green fluorescent protein (GFP) with either herpes simplex virus or adeno-associated virus. On the other hand, we found robust expression of GFP in hair cells exposed to a recombinant, replication-deficient adenovirus that carried the gene for GFP driven by a cytomegalovirus promoter. Titers of 4 x 10(7) pfu/ml were sufficient for expression in 50% of the approximately 1,000 hair cells in the utricular epithelium; < 1% of the nonhair cells in the epithelium were GFP positive. Expression of GFP was evident as early as 12 h postinfection, was maximal at 4 days, and continued for at least 10 days. Over the first 36 h there was no evidence of toxicity. We recorded normal voltage-dependent and transduction currents from infected cells identified by GFP fluorescence. At longer times hair bundle integrity was compromised despite a cell body that appeared healthy. To assess the ability of adenovirus-mediated gene transfer to alter hair cell function we introduced the gene for the ion channel Kir2.1. We used an adenovirus vector encoding Kir2.1 fused to GFP under the control of an ecdysone promoter. Unlike the diffuse distribution within the cell body we observed with GFP, the ion channel-GFP fusion showed a pattern of fluorescence that was restricted to the cell membrane and a few extranuclear punctate regions. Patch-clamp recordings confirmed the expression of an inward rectifier with a conductance of 43 nS, over an order of magnitude larger than the endogenous inward rectifier. The zero-current potential in infected cells was shifted by -17 mV. These results demonstrate an efficient method for gene transfer into both vestibular and auditory hair cells in culture, which can be used to study the effects of gene products on hair cell function.  (+info)

Tracheal aspirate as a substrate for polymerase chain reaction detection of viral genome in childhood pneumonia and myocarditis. (8/761)

BACKGROUND: Infectious respiratory disorders are important causes of childhood morbidity and mortality. Viral causes are common and may lead to rapid deterioration, requiring mechanical ventilation; myocardial dysfunction may accompany respiratory decompensation. The etiologic viral diagnosis may be difficult with classic methods. The purpose of this study was to evaluate polymerase chain reaction (PCR) as a diagnostic method for identification of causative agents. METHODS AND RESULTS: PCR was used to amplify sequences of viruses known to cause childhood viral pneumonia and myocarditis. Oligonucleotide primers were designed to amplify specific sequences of DNA virus (adenovirus, cytomegalovirus, herpes simplex virus, and Epstein-Barr virus) and RNA virus (enterovirus, respiratory syncytial virus, influenza A, and influenza B) genomes. Tracheal aspirate samples were obtained from 32 intubated patients and nucleic acid extracted before PCR. PCR results were compared with results of culture, serology, and antigen detection methods when available. In cases of myocarditis (n=7), endomyocardial biopsy samples were analyzed by PCR and compared with tracheal aspirate studies. PCR amplification of viral genome occurred in 18 of 32 samples (56%), with 3 samples PCR positive for 2 viral genomes. Amplified viral sequences included RSV (n=3), enterovirus (n=5), cytomegalovirus (n=4), adenovirus (n=3), herpes simplex virus (n=2), Epstein-Barr virus (n=1), influenza A (n=2), and influenza B (n=1). All 7 cases of myocarditis amplified the same viral genome from heart as found by tracheal aspirate. CONCLUSIONS: PCR is a rapid and sensitive diagnostic tool in cases of viral pneumonia with or without myocarditis, and tracheal aspirate appears to be excellent for analysis.  (+info)

TY - JOUR. T1 - Safety and Efficacy of CMX001 as Salvage Therapy for Severe Adenovirus Infections in Immunocompromised Patients. AU - Florescu, Diana F.. AU - Pergam, Steven A.. AU - Neely, Michael N.. AU - Qiu, Fang. AU - Johnston, Christine. AU - Way, SingSing. AU - Sande, Jane. AU - Lewinsohn, Deborah. AU - Guzman-Cottrill, Judith. AU - Graham, Michael L.. AU - Papanicolaou, Genovefa. AU - Kurtzberg, Joanne. AU - Rigdon, Joseph. AU - Painter, Wendy. AU - Mommeja-Marin, Herve. AU - Lanier, Randall. AU - Anderson, Maggie. AU - van der Horst, Charles. PY - 2012/5. Y1 - 2012/5. N2 - No therapeutic agent has yet been established as the definitive therapy for adenovirus infections. We describe the clinical experience of 13 immunocompromised patients who received CMX001 (hexadecyloxypropyl cidofovir), an orally bioavailable lipid conjugate of cidofovir, for adenovirus disease. We retrospectively analyzed 13 patients with adenovirus disease and viremia treated with CMX001; data were available for ...
Purpose : Mechanisms used by epidemic keratoconjunctivitis (EKC)-causing adenoviruses to overcome the mucosal barrier of the ocular surface epithelium and initiate infection remain unknown. At the 2015 ARVO General Meeting, we reported that an EKC-causing adenovirus, but not a non-EKC-causing one, induces release of the ectodomain of MUC16 - a membrane-associated mucin (MAM) with barrier functions - from human corneal epithelial cells. The purpose of this study is to determine if MUC16 ectodomain release facilitates adenoviral infection of ocular surface epithelial cells. Methods : Telomerase-immortalized human corneal-limbal epithelial (HCLE) cells, grown to confluence and allowed to differentiate for optimal mucin expression, were exposed to human adenoviruses HAdV-D37 (EKC-causing) and HAdV-D19p (non-EKC-causing) at an MOI of 3. As a measure of epithelial barrier function, rose bengal dye penetrance assays were performed on HCLE cells exposed to HAdV-D37 and HAdV-D19p for 2 h. To compare ...
Infection of mice or rats with adenoviruses can alter their normal immune response and thereby skew experimental data. For example, infection with MAD-1 can produce extensive persistent lesions in the kidneys of adult mice and render them more susceptible to experimental Escherichia coli-induced pyelonephritis. Mouse adenovirus infection has also been shown to accelerate experimental scrapie infection in mice. Although mouse adenoviral infection is usually subclinical in immunocompetent mice, wasting may result in nude mice. ...
Adenoviruses (HAdV) can cause serious life threatening infections, especially in pediatric patients after allogeneic stem cell transplantation (SCT). To improve the morbidity and mortality rate of HAdV infected patients after SCT three issues have been explored: which patients are at risk for HAdV infection, what is the best treatment for ... read more HAdV infected patients and when do we start treatment. We found that in pediatric patients HAdV-DNA positivity in nasopharyngeal aspirate before SCT is a very important risk factor for developing invasive HAdV infection after SCT. As determined with multiplex immuno-assay we also found that children with a localized HAdV infection have a different cytokine profile compared with patients with an invasive HAdV infection after SCT. Cytokine signatures can also be helpful to differentiate invasive HAdV infection from other SCT related complications as Graft versus Host Disease (GvHD) and Epstein-barr virus infection. Immune profiling could possibly ...
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Synonyms for Adenoviridae in Free Thesaurus. Antonyms for Adenoviridae. 2 words related to adenovirus: parainfluenza virus, animal virus. What are synonyms for Adenoviridae?
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BOSC23 cells were transfected with pMSCV PPAR employing Fugene transfection reagent based on the manufacturers protocol. Peroxisome proliferator activated receptor is necessary to allow the differentiation of MEFs ATP-competitive HSP90 inhibitor into adipocytes. The medium then was modified soon after overnight incubation. After 24 h, viral supernatants were filtered by a 0. 45 M Whatman filter and made use of to infect the target cells. The target cells were subjected to two to three rounds of infection and after that underwent assortment working with puromycin. Adenoviral infection of cells. Ad GFP and Ad Cre viruses have been ready with the University of Pennsylvania Gene Treatment Vector Core. Adenovirus was extra to two. 5 ml DMEM at a multiplicity of infection of one,000 for 15 min. Individually, 18 l of Lipofectamine 2000 reagent was extra to two.. five ml of DMEM. The preparations then have been mixed together and incubated for an extra 15 min, following which the mixture was added to ...
Evidence that activation due to anti-adenovirus antibodies may have been responsible for the increased risk of HIV infection in the STEP vaccine trial
Looking for online definition of Adenoviridae infections in the Medical Dictionary? Adenoviridae infections explanation free. What is Adenoviridae infections? Meaning of Adenoviridae infections medical term. What does Adenoviridae infections mean?
Adenovirus vectors have significant potential for long- or short-term gene transfer. Preclinical and clinical studies using human derived adenoviruses (HAd) have demonstrated the feasibility of flexible hybrid vector designs, robust expression and induction of protective immunity. However, clinical use of HAd vectors can, under some conditions, be limited by pre-existing vector immunity. Pre-existing humoral and cellular anti-capsid immunity limits the efficacy and duration of transgene expression and is poorly circumvented by injections of larger doses and immuno-suppressing drugs. This review updates canine adenovirus serotype 2 (CAV-2, also known as CAdV-2) biology and gives an overview of the generation of early region 1 (E1)-deleted to helper-dependent (HD) CAV-2 vectors. We also summarize the essential characteristics concerning their interaction with the anti-HAd memory immune responses in humans, the preferential transduction of neurons, and its high level of retrograde axonal transport in the
Doctors Ask: Adenovirus infection is exposed to all segments of the population. Basic manifestations of adenovirus infection The latent (incubation period) is usually 5-7 days. The disease most often begins acutely, from the phenomena of intoxication: slight increase in temperature, rashes in the body, chills, lethargy, headache, loss of appetite, etc.
Adenovirus infection generally may lead to common cold, pneumonia and pharyngitis.There are few types of adenoviruses. Specifically, adenoviruses types 8,19 and 37 will lead to keratoconjunctivitis mostly in adult.
In one mode of adenovirus infection (called lytic infection because it destroys large numbers of cells), adenoviruses kill healthy cells and replicate up to 1 million new viruses per cell killed, of which 1 to 5 percent are infectious. People with this kind of infection feel sick. In chronic or latent infection, a much smaller number of viruses are released, and healthy cells can multiply more rapidly than they are destroyed. People who have this kind of infection do not exhibit symptoms. Children who have normal immune systems usually experience only minor symptoms when infected with adenovirus. The course of infection tends to be more serious in children who are immunocompromised, such as those undergoing chemotherapy or those who have a disease that disrupts normal immune response (e.g. human immunodeficiency syndrome [HIV]). In such children, the virus more often affects organs such as the lungs, liver, and kidneys, and the risk of fatality increases. Symptoms common to respiratory illnesses ...
Editors Note: Sarah D. (18) wrote this project proposal for research that he will conduct at the Icahn School of Medicine at Mount Sinai ...
The inner-city infants had lower rates of viral detection overall. This may suggest that other factors, such as bacteria or allergic reactions to air pollutions or toxic exposures, contribute significantly to respiratory illness. Sick urban infants had lower rates of two kinds of viruses, HRV and RSV, and higher rates of adenovirus infections, compared to suburban infants. In the urban babies, 4.8 percent of nasal washes tested positive for only adenovirus, while just 0.7 percent of samples from suburban babies were positive for only adenovirus. "Adenovirus infections, either as a single pathogen or when detected in concert with other viruses, were significantly more common in the urban population, and this held true for each of the four urban locations where our study was conducted," the authors wrote ...
Answer: Determine the underlying cause of the membrane/pseudomembrane and treat the underlying disease. In the case of adenoviral infection removal of the inflammatory membrane and application of topical steroids may prevent the formation of symblepharon ...
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Buy L3 antigen, ADENOVIRUS TYPE 5 Antigen-AP_000211.1 (MBS239153) product datasheet at MyBioSource, Antigens. Application: ELISA (EIA)
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Looking for online definition of canine adenovirus type 2 (CAV-2) in the Medical Dictionary? canine adenovirus type 2 (CAV-2) explanation free. What is canine adenovirus type 2 (CAV-2)? Meaning of canine adenovirus type 2 (CAV-2) medical term. What does canine adenovirus type 2 (CAV-2) mean?
Canine Adenovirus Pneumonia in 2 puppies- CAV-2 History: Two English Bulldog puppies (1, and 3 weeks old) had trouble breathing in the morning and by noon had died. Gross Necropsy Findings: Lungs: Diffuse dark red to purple, edematous. Histologic Findings: Lungs: Multifocal necrosis of bronchiolar respiratory epithelium and alveolar pneumocytes. Alveolar septa are expanded by…
TY - JOUR. T1 - Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients. AU - Muller, William J.. AU - Levin, Myron J.. AU - Shin, Young Kyoo. AU - Robinson, Christine. AU - Quinones, Ralph. AU - Malcolm, Janet. AU - Hild, Elaine. AU - Gao, Dexiang. AU - Giller, Roger. PY - 2005/12/15. Y1 - 2005/12/15. N2 - Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT patients, 18 of whom had severe manifestations of infection. Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 patients. In vitro susceptibility to cidofovir was demonstrated in 12 clinical adenovirus isolates. Cidofovir is a promising treatment option for this population.. AB - Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT ...
Inclusion body hepatitis caused by different fowl aviadenovirus (FAdV) serotypes has been described in several countries in recent years. In Spain, from the spring of 2011 to 2013, an increased number of outbreaks in broiler and broiler breeder flocks from different regions occurred. The objectives of the present work were to carry out the molecular characterization of FAdV strains from Spanish inclusion body hepatitis cases and to study the pathogenicity and viral dynamics of these strains in specific pathogen-free (SPF) chickens. A total of 52 inclusion body hepatitis clinical cases, including 45 from broiler farms and seven from broiler breeder farms, were analysed by conventional polymerase chain reaction and sequencing targeting the FAdV hexon gene. From these, 37 strains were classified as FAdV type 8b, while the remaining 15 were classified as FAdV types 11 (n = 10), 2 (n = 4) and 8a (n = 1). In addition, two different FAdVs belonging to the genotypes 8b and 11 were used for experimental ...
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Learn about the programs and services for Adenovirus Infections at Boston Childrens, ranked best Childrens Hospital by US News.
As combining therapeutic agents with different action mechanisms may enhance efficacy, YSC-02, an oncolytic adenovirus with multi targets was loaded with five different genes, which were designed with the expectation that different action mechanisms would cooperate. In spite of concerns regarding many APIs, YSC-02 was constructed to be an adenovirus-based anti-cancer drug. By using our own established mouse model system suitable for efficient adenoviral infection and replication, immune activity as well as survival potential could be precisely estimated for anti-cancer drug efficacy. YSC-02 was designed to decrease tumor cell survival, metastasis and to increase tumor cell death, and immune activation. It is composed of five different target genes, including one fused form and two shRNAs, but each of these genes functions is closely linked to produce the maximal antitumor effect. YSC-02 is like an organic complex designed to be applied primarily to heterogeneous liver cancer and melanoma. The ...
Vincent and Rich speak with Alice and Kathy about their work on HIV genome dimerization, and packaging and pathogenesis of mouse adenovirus.
Feucht, Judith; Opherk, Kathrin; Lang, Peter; Kayser, Simone; Hartl, Lena; Bethge, Wolfgang; Matthes-Martin, Susanne; Bader, Peter; Albert, Michael H.; Maecker-Kolhoff, Britta; Greil, Johann; Einsele, Hermann; Schlegel, Paul-Gerhardt; Schuster, Friedhelm R.; Kremens, Bernhard; Rossig, Claudia; Gruhn, Bernd; Handgretinger, Rupert; Feuchtinger, Tobias ...
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Adenoviruses are ubiquitous. Weve all been infected with lots of them (gets to be a problem when making gene therapy vectors). The older you are, the more likely you have been exposed to the different kinds of adenovirus, to the point where if you are an adult reading this, you probably have antibodies to serotypes 1, 2, 5, and/or 6 (depending on where you live).. Thus older children are more likely to have been exposed to any adenovirus, including Ad-36. If your obese group of children is 63% kids aged 15-18, and your healthy weight group is only 17% 15-18, I am not shocked at all that antibodies to Ad-36 is correlated with obesity. I bet you could have picked any other adenovirus serotype and found the same correlation. But they didnt look.. William M. Briggs gets it. I dunno the dude. Statistician. But he gets it. *thumbs-up*. From a virologists perspective, there are putative, plausible mechanisms for how Ad-36 could actually play a role in obesity. Those reasonings require ongoing ...
Adenovirus Type 9, 0.1 mg. The many different serotypes of human adenoviruses (Ad) are divided into six subgroups, of which all Ad subgroup A and B and two subgroup D Ads can elicit tumors in infected rodents.
This post is about adenovirus infection, a major cause of illness both minor and severe in the United States, especially among children in group settings.
Publications 164 Publications PUBLICATIONS 1. Heemskerk B, Veltrop-Duits LA, van Vreeswijk T, ten Dam MM, Heidt S, Toes RE, van Tol MJ, Schilham MW. Extensive cross-reactivity of CD4 + adenovirus-specific
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-Maintains strong financial position with $314.5 million in capital at quarter end-. DURHAM, N.C., May 09, 2016-- Chimerix, a biopharmaceutical company developing novel antivirals to address unmet medical needs, today reported top-line results from an interim analysis of the AdVise trial of brincidofovir for serious adenovirus infection and other corporate...
Looking for inclusion body hepatitis? Find out information about inclusion body hepatitis. Any of the abnormal structures appearing within the cell nucleus or the cytoplasm during the course of virus multiplication Explanation of inclusion body hepatitis
Human adenovirus, of the Adenoviridae family, is a nonenveloped icosahedral particle containing a single linear dsDNA genome. Human adenovirus comprises 6 species (A through F) consisting of serotypes 1 - 51, and associated with a variety of clinical illnesses. Serotypes 1-39, 42-51 are associated with a variety of respiratory disease, generally in children and immunocompromised persons; whereas serotypes 40 and 41 is associated with enteric disease (enteric adenovirus) particularly in children - these enteric adenoviruses will not be detected with the assay described here. Serotypes 12, 18, 31 have a high oncogenic potential and serotypes 4 and 7 are associated with acute respiratory disease (ARD) frequently in military recruits and typically occur in the winter and spring. Smaller outbreaks of serotypes 3, 4, and 7 occur in the summertime and are associated with contaminated swimming pool water.. Adenovirus infections of the eye may lead to pharyngo-conjunctival fever, follicular ...
Corneal subepithelial infiltrates are a known complication of adenoviral conjunctivitis.1 These lesions usually become apparent within 10-14 days after onset of symptoms and in some cases may persist for months or even years after the acute phase of the infection. Although the opacities gradually fade with time, those associated with reduced visual acuity may require a course of topical corticosteroids. However, return of the opacities can be seen with discontinuation of the corticosteroids.2 In cases of prolonged follicular conjunctivitis, equivocal ocular signs, or suspected superimposed infections, specimen culture is an important tool to aid diagnosis.3,4. Although small star-shaped ulcers (herpetic stellates) have been documented as a clinical manifestation seen in herpes simplex eye infections,5 these lesions have been confined to the corneal epithelium. To our knowledge, no such lesions have been documented in the tarsoconjunctiva, either in adenoviral or herpes simplex viral ...
Enteric viruses transmitted via the faecal-oral route occur in high concentrations in wastewater and may contaminate drinking water sources and cause disease. In order to quantify enteric adenovirus...
Albinana-Gimenez N., M.P. Miagostovich, B. Calgua, J.M. Huguet, L. Matia and R. Girones. 2009. Analysis of adenoviruses and polyomaviruses quantified by qPCR as indicators of water quality in source and drinking-water treatment plants. Water Res. 43:2011-2019. [PubMed]. Barrella K.M., P. Garrafa, T.A. Monezi, C.M. Harsi, C. Salvi, P.A. Violante and D.U. Mehnert. 2009. Longitudinal study on occurrence of adenoviruses and hepatitis A virus in raw domestic sewage in the city of Limeira, Sao Paulo. Braz. J. Microbiol. 40:102-107. [PubMed]. Bibby K. and J. Peccia. 2013. Prevalence of respiratory adenovirus species B and C in sewage sludge. Environ. Sci. Process Impacts. 15(2):336-8 [PubMed]. Cantalupo P.G, B. Calgua, G. Zhao, A. Hundesa, A.D. Wier, J.P. Katz, M. Grabe, R.W. Hendrix, R. Girones, D. Wang and others. 2011. Raw sewage harbors diverse viral populations. MBio. 2(5):e00180-11 [PubMed]. Cruz J.R., P. Caceres, F. Cano, J. Flores, A. Bartlett and B. Torun. 1990. Adenovirus types 40 and 41 and ...
Alonso-Padilla J, Papp T, Kaján GL, Benkő M, Havenga M, Lemckert A, Harrach B, Baker AH (2016) Development of novel adenoviral vectors to overcome challenges observed with HAdV-5 based constructs. Mol Ther. 24:6-16. doi:10.1038/mt.2015.194. Marek A, Kajan GL, Kosiol C, Harrach B, Schlotterer C, Hess M (2014) Complete genome sequences of pigeon adenovirus 1 and duck adenovirus 2 extend the number of species within the genus Aviadenovirus. Virology 462-463C:107-114. doi:10.1016/j.virol.2014.04.033. Kaján GL, Kecskeméti S, Harrach B, Benkő M (2013) Molecular typing of fowl adenoviruses, isolated in Hungary recently, reveals high diversity. Vet Microbiol. 167:357-363. doi:10.1016/j.vetmic.2013.09.025. Marek A, Kosiol C, Harrach B, Kaján GL, Schlötterer C, Hess M (2013) The first whole genome sequence of a Fowl adenovirus B strain enables interspecies comparisons within the genus Aviadenovirus. Vet Microbiol. 166:250-256. doi: 10.1016/j.vetmic.2013.05.017. Zadravec M, Slavec B, Krapez U, Kajan ...
The present study describes the development of a SYBR Green based real-time polymerase chain reaction (real-time PCR) for detection and quantitation of all fowl adenovirus (FAdV) species. Primers were designed based on conserved nucleotide sequences within the 52K gene. Ten-fold serial dilutions of a vector DNA were used as standard for quantitation. The real-time PCR had an efficiency of 98%, a regression squared value of 0.999 and showed a range of 6.73-6.73×10(8) copies of FAdV DNA per reaction. The assay was highly specific for FAdVs and an exact quantitation of all 5 FAdV species (FAdV-A to FAdV-E) could be demonstrated. It was shown, that twelve FAdV serotypes (FAdV-1 to 8a, and 8b to 11) were detectable and quantifiable. Other viral genomes as well as uninfected chicken embryo liver (CEL) cells did not produce positive signal. Cloacal swabs were taken during the animal experiment, which was performed with all FAdV species. Shedding of FAdVs was investigated in cell culture, by ...
... , Nobivac Canine is for the vaccination of healthy dogs as an aid in prevention of infectious disease associated with canine adenovirus type 2, canine parainfluenza virus,
Univac 5 dog shot is a modified-live virus for the vaccination of healthy, susceptible dogs and puppies as an aid in the reduction of diseases caused by canine distemper, canine adenovirus types 1 and 2, parainfluenza and parvovirus. Dosage: 1 ml IM or subcut, repeat in 3-4 weeks. Puppies vaccinated before 9 weeks should be revaccinated at
The oncolytic potency of CRAds is critically linked to effective adenoviral infection and replication. First, there must be efficient infection in target cells. To this end, we have shown gains in infectivity via CAR-independent infection to overcome the hurdle that most tumor cells are deficient with respect to the level of the CAR receptor. These gains provide a logical framework for addressing other biological factors related to CRAd potency, such as efficacy of replication, as studied here. Furthermore, elucidation of distinct mechanisms will allow us to develop a strategy to circumvent other barriers and improve the potency of CRAds. In the present study, we endeavored to define the replicative blocks that may be limiting the full potential of oncolytic CRAds.. We showed that immortalized cell lines support wild-type adenoviral replication to a much greater degree than primary patient tumors. Because fiber and hexon are both late proteins involved in the assembly of virions, it was expected ...
Adenovirus and pregnancy - What is adenovirus infection? Many forms. This virus can produce several forms of infection. Pharyngo-conjunctival fever (or swimming pool fever) is one of the better known, but also gastroenteritis, upper respiratory tract infections and pneumonia can all occur.
Human adenovirus 2 ATCC ® VR-846D™ Designation: DNA from Human adenovirus 2 strain Adenoid 6 [ATCC ® VR-846™] Application: It is suitable for use in polymerase chain reaction (PCR) for viral gene products and other molecular virology applications. Respiratory research
Human adenovirus 4 ATCC ® VR-1572D™ Designation: DNA from Human adenovirus 4 strain RI-67 [ATCC ® VR-1572™] Application: It is suitable for use in polymerase chain reaction (PCR) for viral gene products and other molecular virology applications. Respiratory research
13:2; potential epub Adenovirus notions; tenure bhakti 1? On the epub Adenovirus Methods and of this interest, are above under form. 1282 An epub Adenovirus Methods and Protocols: Adenoviruses, Ad study read by Porten - Szubin 1987:187.
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Assessments for safety and tolerability as measured as the acute and late adverse effects, laboratory parameters, biodistribution of the vector, anti-adenovirus antibodies and VEGF-levels before and in several time points after the gene transfer ...
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Introduction. According to the International Committee on Taxonomy of Viruses (ICTV), host range specificity, genomic organisation, virion properties, structure, size and serological differences divide the large family of Adenoviridae into four distinct genera (Benkő et al. 2005). At present, these genera areMastadenovirus (infecting mammals), Aviadenovirus (infecting birds), Atadenovirus (named after the bias of their genomes containing high A+T content infecting a broad range of hosts including ruminants, as well as avian, reptilian and marsupial hosts), and Siadenovirus (infects birds and frogs). The fifth suggested genus is called Ichtadenovirus, isolated from fish (Benkő et al. 2005; Kovács et al. 2003).. The genus Aviadenovirus is further divided into eight species: Falcon adenovirus A, Fowl adenovirus(FAdV) A, Fowl adenovirus B, Fowl adenovirus C, Fowl adenovirus D, Fowl adenovirus E, Goose adenovirus A and Turkey adenovirus B. Fowl adenovirus 1 (FAdV-1) belongs to species A and FAdV-5 ...
Gene probes developed locally for both enteric Adenoviruses 40 and 41 were used to determine whether these viruses were present in both raw and treated waters. Approximately sixty water samples were concentrated by ultra filtration and analysed directly for the presence of enteric adenoviruses. Three pre-treatment techniques, namely sephadex columns, cellulose fibre and Geneclean(TM) were tested for the removal of inhibitory substances from concentrated water samples. The effect of chlorine treatment on viral detection using gene probe hybridization was also examined by exposing adenoviruses to chlorine concentrations of up to 20mg/l for 1 hour. Enteric adenoviruses were detected in up to 59% of both raw and treated waters analysed, Cellulose fibre and Geneclean(TM) were found to successfully remove inhibitory substances from concentrated raw waters. Viral I NA was detected after exposure to a range of chlorine concentrations indicating that the viruses detected in the treated waters may have ...
ABSTRACT. Canine adenovirus (CAV) type 1 and 2, respectively, cause infectious canine hepatitis and infectious canine laryngotracheitis in members of the families Canidae and Ursidae worldwide. Both of these infections are acute diseases, especially in young dogs. The aim of this study was to conduct a serological investigation of canine adenovirus infection. For this purpose, serum samples were collected from native pure-bred Kangal (n = 11), and Akbash dogs (n = 17) and Turkish Greyhounds (n = 15) in Eskisehir and Konya provinces. None of the dogs were previously vaccinated against CAV types. Indirect ELISA detected 88.2 %, 93.3 % and 100 % prevalences in Akbash, Greyhound and Kangal dogs, respectively. The remainder of the samples (n = 51) were collected at the Afyonkarahisar Municipality Shelter. Fourty-two of these dogs (82.3 %) were detected as seropositive. In total, 82 of 94 dogs (87.2 %) were found to be positive for CAV serum antibodies.. Keywords: antibody, canine adenovirus, dog, ...
Adenovirus type 37 (Ad37) is a leading cause of epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular disease. Whereas most other adenoviruses infect cells by engaging CD46 or the coxsackie and adenovirus receptor (CAR), Ad37 binds previously unknown sialic acid-containing cell surface molecules. By glycan array screening, we show here that the receptor-recognizing knob domain of the Ad37 fiber protein specifically binds a branched hexasaccharide that is present in the GD1a ganglioside and that features two terminal sialic acids. Soluble GD1a glycan and GD1a-binding antibodies efficiently prevented Ad37 virions from binding and infecting corneal cells. Unexpectedly, the receptor is constituted by one or more glycoproteins containing the GD1a glycan motif rather than the ganglioside itself, as shown by binding, infection and flow cytometry experiments. Molecular modeling, nuclear magnetic resonance and X-ray crystallography reveal that the two terminal sialic acids dock into two of
The outer shell of the adenovirus capsid comprises three major types of protein (hexon, penton base and fiber) that perform the majority of functions facilitating the early stages of adenovirus infection. respect to the delivery of foreign molecules. Adenovirus capsid tasks in early illness The adenovirus (Ad) is definitely a non-enveloped, dsDNA disease whose outer shell of the icosahedral-shaped capsid is definitely comprises three major types of proteins: hexon, penton foundation and dietary fiber (Number 1). The hexon comprises the majority of the outer shell of the Ad capsid, forming 240 homotrimers that encapsidate the majority of the disease, including the viral genome and connected proteins [1]. The dietary fiber protrudes from each of the 12 vertices of the icosahedron, while the penton foundation lies at the base of each dietary fiber. These three capsid proteins contribute to the majority of activities required for the early phases of Ad infection. Number 1 Representation of ...
These DNA viruses (unlike other adenoviruses) could not be cultured using standard virus culture systems. The most frequent are types 40 and 41. These enteric adenovirus species are the second most common cause of severe gastroenteritis in young children (after rotavirus), comprising about 10%-15% of cases (range, 5%-52%). It has also been the second or third most common overall cause of infant gastroenteritis. Diarrhea is the predominant symptom. Vomiting may be present but is less prominent than that seen in rotavirus infection. The gold standard for diagnosis has been EM of stool specimens. However, EM cannot differentiate between fastidious and other adenovirus species. Culture can be done in some cases using nonroutine tissue culture cells. Several EIA tests for virus antigen in stool have been described and one commercial kit for types 40 and 41 is now available. Nucleic acid probes have also been used experimentally.. ...
RNA molecules from nuclear and cytoplasmic polyribosomes of adenovirus-infected HeLa cells were compared by hybridization to analyse the sequence content. Nuclear polyribosomes were released by exposure of intact detergent-washed nuclei to poly(U) and purified. Cytoplasmic polyribosomes were also purified from the same cells. To show that nuclear polyribosomes contain ribosomes linked by mRNA, polyribosomes were labelled with methionine and uridine in the presence of actinomycin D in adenovirus-infected cells. Purified nuclear polyribosomes were treated with EDTA under conditions which dissociate polyribosomes into ribosomes and subunits with a simultaneous release of mRNA, and sedimented. The treatment dissociated these polyribosomes, releasing the mRNA from them. Radiolabelled total RNA from each polyribosome population was fractionated in sucrose gradients into several pools or hybridized to intact adenovirus DNA to select virus-specific RNA. Sucrose-gradient-fractionated pool-3 RNA (about ...
Seventy-eight cases were identified in patients from four eye care practices, two family practices, and the hospital emergency department. The median patient age was 45 years (range = 9 months-90 years), and 33 (42%) were men. Ocular signs and symptoms included redness (68%), watery discharge (50%), and pain (29%). Severe signs included corneal infiltrates (17%) and pseudomembranes (6%). At least 12 cases (15%) were health care-associated (Figure). One health care-associated case occurred in a health care worker. Seventeen patients whose infections were not health care-associated reported a symptomatic household or community contact. Among 45 conjunctival swabs available for testing, 19 (42%) were positive for HAdV-8. Genome sequences obtained from five HAdV-8 isolates were 100% identical with one another and showed 97.7% (accession number AB861610.1) to 99.9% (accession number KT340070.1) nucleotide sequence similarity to other HAdV-8 genome sequences available in GenBank, the National ...
In 2005, a human adenovirus strain (formerly known as HAdV-D22/H8 but renamed here HAdV-D53) was isolated from an outbreak of epidemic keratoconjunctititis (EKC), a disease that is usually caused by HAdV-D8, -D19, or -D37, not HAdV-D22. To date, a complete change of tropism compared to the prototype has never been observed, although apparent recombinant strains of other viruses from species Human adenovirus D (HAdV-D) have been described. The complete genome of HAdV-D53 was sequenced to elucidate recombination events that lead to the emergence of a viable and highly virulent virus with a modified tropism. Bioinformatic and phylogenetic analyses of this genome demonstrate that this adenovirus is a recombinant of HAdV-D8 (including the fiber gene encoding the primary cellular receptor binding site), HAdV-D22, (the ε determinant of the hexon gene), HAdV-D37 (including the penton base gene encoding the secondary cellular receptor binding site), and at least one unknown or unsequenced HAdV-D strain.
In 2005, a human adenovirus strain (formerly known as HAdV-D22/H8 but renamed here HAdV-D53) was isolated from an outbreak of epidemic keratoconjunctititis (EKC), a disease that is usually caused by HAdV-D8, -D19, or -D37, not HAdV-D22. To date, a complete change of tropism compared to the prototype has never been observed, although apparent recombinant strains of other viruses from species Human adenovirus D (HAdV-D) have been described. The complete genome of HAdV-D53 was sequenced to elucidate recombination events that lead to the emergence of a viable and highly virulent virus with a modified tropism. Bioinformatic and phylogenetic analyses of this genome demonstrate that this adenovirus is a recombinant of HAdV-D8 (including the fiber gene encoding the primary cellular receptor binding site), HAdV-D22, (the ε determinant of the hexon gene), HAdV-D37 (including the penton base gene encoding the secondary cellular receptor binding site), and at least one unknown or unsequenced HAdV-D strain.
The interaction between clinicians and patients produces a dynamic that can affect both and forms a part of the risk associated with medical practice. The clinician can sometimes become the main agent for the spread of disease by omissions, which usually do not affect the medical personnel or the patients. However, under certain circumstances, members of the medical workforce can become risks for their own health and that of their patients by becoming a vector for disease transmission. In this study, we report on an outbreak of conjunctivitis involving both clinicians and patients. Human adenovirus (Ad) belongs to a family comprising about 100 members that are grouped into six subgenera (A-F) based on several biochemical and molecular criteria. Fifty-one Ad types have been identified as human pathogens, some of which are able to survive under adverse conditions outside of the human body [1,2]. A typical Ad infection includes a 5-12 day incubation period before the onset of symptoms followed by a ...
Nasopharyngeal aspirates and stool specimens may be useful when the patient has fever and a rash and an enteroviral infection is suspected. Adenoviruses can be cultured from the urine of patients with hemorrhagic cystitis. CMV can frequently be isolated from cultures of urine or buffy coat. Biopsy material can be effectively cultured when viruses infect major organs, as in HSV encephalitis or adenovirus pneumonia. Virus isolation does not necessarily establish disease causality.Viruses can persistently or intermittently colonize normal human mucosal surfaces. Saliva can be positive for herpesviruses, and normal urine samples can be positive for CMV. Isolations from blood, cerebrospinal fluid (CSF), or tissue are more often diagnostic of significant viral infection. Another method aimed at increasing the speed of viral diagnosis is direct testing for antigen or cytopathic effects. Virus-infected cells from the patient may be detected by staining with virus-specific monoclonal antibodies; e.g., ...
Recombinant adenoviruses currently are used for a variety of purposes, including gene transfer in vitro, vaccination in vivo, and gene therapy (1-4). Several features of adenovirus biology have made such viruses the vectors of choice for certain of these applications. For example, adenoviruses transfer genes to a broad spectrum of cell types, and gene transfer is not dependent on active cell division. Additionally, high titers of viruses and high levels of transgene expression generally can be obtained.. Decades of study of adenovirus biology have resulted in a detailed picture of the viral life cycle and the functions of the majority of viral proteins (5, 6). The genome of the most commonly used human adenovirus (serotype 5) consists of a linear, 36-kb, double-stranded DNA molecule. Both strands are transcribed and nearly all transcripts are heavily spliced. Viral transcription units are conventionally referred to as early (E1, E2, E3, and E4) and late, depending on their temporal expression ...
Adenovirus has been associated with both sporadic and epidemic disease and, with regard to infections among military recruits, who were routinely immunized against types 4 and 7 from 1971 until the cessation of vaccine production in 1996. Adenovirus became a significant cause of economic cost and morbidity in this setting. A live oral vaccine against adenovirus types 4 and 7 was approved for use in this population by the US Food and Drug Administration (FDA) in 2011, and subsequent incidence of acute respiratory disease declined.. Of interest is the role of adenoviruses as vectors in vaccination and in gene therapy. [1, 2, 3] Adenoviruses can infect various cells, both proliferating and quiescent, and thus hold the promise of targeting many different tissues and diseased cell lines.. The genome of adenovirus is well known and can be modified with relative ease to induce lysis or cytotoxicity of a specified cell line without affecting others.. The virus itself can be engineered to remove its ...
The infant, born at 29 6/7 weeks gestation, was diagnosed with disseminated adenovirus infection at two weeks post-partum after acquiring the virus from the childs mother. Given the high mortality associated with this infection in a neonate, Dr. Auletta looked outside the box for answers.. "For babies born at term with no other medical considerations, this type of adenovirus infection has a mortality rate around 85%," says Dr. Auletta, who is also a professor of Pediatrics at The Ohio State University College of Medicine (OSUCOM). "This infant was born preterm and was already struggling with an underdeveloped immune system. The prognosis in this case was not good.". So, he called Dean Lee, MD, PhD, director of the Cellular Therapy and Cancer Immunology Program at Nationwide Childrens and The Ohio State University Comprehensive Cancer Center (OSUCCC), and together they developed a plan. Dr. Lees program uses immune cells to treat disease in an effort to produce better outcomes than outcomes ...
Cell culture and transient transfection. Mouse WT and Cd2ap-/- (18) podocytes were cultured as described previously (42). HEK 293 cells were maintained and transfected using Lipofectamine 2000 reagent (Invitrogen) as previously reported (6). Adenoviral infections of cultured podocytes were preformed as described previously (6). Lentiviral infection. Lentiviral shRNA plasmids for CatL were obtained from Open Biosystems and were used to generate lentiviral transduction particles in HEK 293T cells. We used a target set of 3 clones with pLKO.1,-puro as the parental vector (see Supplemental Table 1 for sequences). Lentiviral shRNA plasmids for dendrin were obtained from Sigma Aldrich and were used to generate lentiviral transduction particles in HEK 293T cells. We used a target set of 2 clones with pLKO.1,-puro as a parental vector (Supplemental Table 1). Lentiviral knockdown of mouse CatL and dendrin were performed in differentiated mouse and high-Tgfb1Cd2ap-/- podocytes according to the protocol ...
Purification of recombinant adenovirus type 3 dodecahedric virus-like particles for biomedical applications using short monolithic columns
There are many stages in the development of a new drug for viral infection and such processes are even further complicated for adenovirus by the fact that there are at least 51 serotypes, forming six distinct groups (A-F), with different degree of infectivity. This review attempts to address the importance of developing pharmaceuticals for adenovirus and also review recent development in drug discovery for adenovirus, including newer strategies such as microRNA approaches. Different drug screening strategies will also be discussed.
Mouse Monoclonal Anti-Adenovirus Hexon Antibody (3G0) [DyLight 488]. Validated: ELISA, ICC/IF. Tested Reactivity: Virus. 100% Guaranteed.
Virologic and Serologic Studies on Infectious Mononucleosis-like Disease in Children, with Special Reference to Cytomegalovirus, Epstein-Barr Virus and Adenovirus Infections (1974 ...
Scientists are reporting discovery of a potential new drug for epidemic keratoconjunctivitis (EKC) -- sometimes called pink eye -- a highly infectious eye disease that may occur in 15 million to 20 million people annually ...
Detect adenovirus rescue even before cytopathic effect (CPE) is observed. Ensure high titer by harvesting amplified adenovirus at the optimal time
Detect adenovirus rescue even before cytopathic effect (CPE) is observed. Ensure high titer by harvesting amplified adenovirus at the optimal time
Rs instructions. Each recombinant adenovirus was selected after three rounds of plaque purification in HEK293 cells and was separately identified by PCR. The
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Define epidemic keratoconjunctivitis. epidemic keratoconjunctivitis synonyms, epidemic keratoconjunctivitis pronunciation, epidemic keratoconjunctivitis translation, English dictionary definition of epidemic keratoconjunctivitis. n. Inflammation of the cornea and conjunctiva. Noun 1. keratoconjunctivitis - inflammation of the cornea and conjunctiva inflammation, redness, rubor - a...
Adenovirus 1 in canines causes respiratory infections, targets a number of organs within the physique, and causes infectious canine hepatitis (ICH), which is a illness that severely impacts the liver ... ...
186\186"Microscopically, extensive dystrophic changes and necroses of liver parenchyma are detected. In the nuclei of hepatocytes, basophilic or eosinophilic inclusion bodies are detected. The basophilic inclusion bodies are usually dense and occupy the entire nuclear inner space (arrow b), whereas the eosinophilic ones are round or irregularly shaped and surrounded by a light halo (arrow e). The diagnosis is based upon the typical gross lesions and the history records.A principal approach in IBH diagnostics is the histological investigation that helps to detect the intranuclear inclusion bodies. IBH should be distinguished mainly from IBD and chicken infectious anaemia (CIA). With regard to IBH prevention and control, the eggs of broiler parent flocks, where the disease is consecutively appearing in the progeny, should not be used for hatching. The access of wild birds should be prevented as they are potential carriers and distributors of the virus. The most important steps in IBH prevention ...
I had Epidemic Keratoconjunctivitis 2.5years ago and still have scarring on my cornea, intense glare sensitivity and am still wearing glasses for every day use (I never wore them before the infection)....
We determined the complete genome sequence of epidemic keratoconjunctivitis (EKC)-related human adenoviruses (HAdVs). We analysed a total of 12 HAdV strains; three prototype strains and two HAdV-8, three HAdV-19 and three HAdV-37 clinical isolates from EKC patients in Japan, and one novel serotype of HAdV. Genome organization of these serotypes was identical to those of the recently determined HAdV-19 and HAdV-37. The identities of the whole genome were over 99 % among strains from the same serotype, except for HAdV-19p, which is not associated with conjunctivitis, resulting in the formation of a distinct cluster in the phylogenetic analysis. The penton, loop 1 and loop 2 of hexon, early region 3 (E3) and fiber were hypervariable regions between serotypes. Results suggest that the HAdV-19 clinical strain is a recombinant of HAdV-19p-like and HAdV-37-like strains, and that the acquisition of the penton, E3 or fiber may be related to ocular tropism.
This book is protected by the copyright law. The reproduction, imitation or distribution of the book in whole or in part, in any format (electronic, photocopies etc.) without the prior consent, in writing, of copyright holders is strictly prohibited ...
Transarterial chemoembolization (TACE) is currently one of the mainstays of palliative treatments worldwide for patients with unresectable Hepatocellular Carcinoma(HCC).However, the long term outcomes were generally poor for HCC patients treated with TACE. Recombinant Human Adenovirus Type 5, an E1B gene deleted adenovirus, is known to have a significant antitumor activity. In addition, local injection of recombinant human adenovirus type 5 can enhance the effect of antitumor therapies (chemotherapy and radiotherapy). The hypothesis is that patients with unresectable HCC may benefit from recombinant human adenovirus type 5 in combination with TACE ...
We present eight cases and review the literature of concurrent urethritis and conjunctivitis where adenovirus was identified as the causative pathogen. The focus of this review concerns the identification of specific sexual practices, symptoms, signs and any serotypes that seem more commonly associated with such adenovirus infections. We discuss the seasonality of adenovirus infection and provide practical advice for clinicians to give to the patient.. ...
The outer shell of the adenovirus capsid comprises three major types of protein (hexon, penton base and fiber) that perform the majority of functions facilitating the early stages of adenovirus infection. respect to the delivery of foreign molecules. Adenovirus capsid tasks in early illness The adenovirus (Ad) is definitely a non-enveloped, dsDNA disease whose outer shell of the icosahedral-shaped capsid is definitely comprises three major types of proteins: hexon, penton foundation and dietary fiber (Number 1). The hexon comprises the majority of the outer shell of the Ad capsid, forming 240 homotrimers that encapsidate the majority of the disease, including the viral genome and connected proteins [1]. The dietary fiber protrudes from each of the 12 vertices of the icosahedron, while the penton foundation lies at the base of each dietary fiber. These three capsid proteins contribute to the majority of activities required for the early phases of Ad infection. Number 1 Representation of ...
Background. Military recruits are at a higher risk of respiratory infection than their civilian counterparts. Continuous outbreaks of adenovirus (Ad)â€"associated acute respiratory disease were documented among US trainees before the implementation of serotype 4 (Ad4) and serotype 7 vaccines in 1971. The discontinuation of Ad vaccination programs in 1999 precipitated the reemergence of Ad in training sites, with Ad4 accounting for 98% of all diagnosed cases. Methods. A total of 724 Ad4 strains isolated from recruits presenting with febrile respiratory illness at 8 training sites nationwide between 1997 and 2003 were genome typed by restriction enzyme analysis. Results. Seven genome types were identified, all of which were distinct from the prototype Ad4p and the vaccine type 4p1. Results showed very different, and often stable, genome type distributions at different geographic sites, despite the homogeneity of the recruit source population. Conclusions. The data support the hypothesis that ...
Adenoviruses (HAdVs) are nonenveloped lytic DNA viruses with 67 different human serotypes. HAdV infection post transplant seems to be caused by endogenous viral reactivation in most cases....
Austin Journal of Clinical Ophthalmology is an open access, Peer Review journal dedicated to publish articles in all areas of Clinical Ophthalmology.
We studied the mutagenic and carcinogenic effects on mammalian cells of two EcoRI DNA fragments of bovine adenovirus type3 (BAV-3) integrated into the pBR325 plasmid. Fragment D located between 3.6 and 19.7 map units, contains the viral oncogene, fragment C, located between 44.3 and 63.7 map units, has no oncogenic activity. The BAV-3 oncogene was shown to increase significantly the frequency of 6-mercaptopurine (6MP)-resistant mutants in Chinese hamster calls. Fragment C, pBR325 without viral sequences and DNA from normal Syrian hamster cells did not have any mutagenic effect. We also looked at the combined action of the viral DNA fragments and the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), which enhances the transforming effect of carcinogens. TPA was shown to increase the mutant yield on exposure to the viral oncogene but not to induce mutagenic activity in those types of DNA that are unable to transform cells. Probably TPA does not affect the initiation of the mutation ...
Univac 9 for the vaccination of healthy dogs as an aid in the prevention of canine distemper, infectious canine hepatitis, respiratory disease caused by canine adenovirus type 2, parainfluenza, parvovirus and lepospirosis infections. Syringe included.
Nobivac Intra-Trac3 ADT is for the prevention of Canine Adenovirus Type 2, Parainfluenza, Bordetella Bronchiseptica Vaccine (MLV). For INTRANASAL use in healthy dogs including pregnant females and healthy puppies.
It has been known for some time that the human adenovirus serotype 5 (Ad5) E4orf6 and Sox18 E1B55K proteins work in concert to degrade p53 and to regulate selective export of late viral mRNAs during productive infection. H1299 human lung carcinoma cells after expression of E1B55K and E4orf6 using adenovirus vectors. Several species were detected and identified by mass spectroscopy and for one of these integrin α3 we went on in a parallel study to confirm it as a substrate of the complex (F. Dallaire et al. J. Virol. 83:5329-5338 2009 Although the system has some limitations it may still be of some general use in identifying candidate substrates of any viral cullin-based E3 ubiquitin ligase complex and we suggest a series of criteria for substrate validation. During the past decade protein degradation has become increasingly recognized SVT-40776 (Tarafenacin) as a critical mechanism by which cells regulate a number of fundamental processes (reviewed in references 37 57 and 59). Degradation ...
Full custom adenovirus production services, adenovirus vector construction, adenovirus packaging, adenovirus amplification, adenovirus purification, adenovirus titering.
Cathy, We are using Chemicons antibody (cat# MAB805) (clones 20/11 and 2/6). We pretreat in 0.01% Pronase at room temperature for 10 minutes. The antibody is run at 1:500 and detected by Vectors Elite ABC technique. It seems to be working nicely. ,Dear histonetters, , , Does anyone have any experience with adenovirus testing on ,paraffin-embedded tissue? What is the most current method available to ,detect adenovirus infection in tissue? , ,With many thanks, , ,Cathy Fragiskatos ,Royal Victoria Hospital ,Montreal, Quebec ,Canada. , Phyllis Davie Clinical Laboratory Supervisor PhenoPath Laboratories Seattle, WA [email protected] (206)374-9009 phone (206)374-9009 fax ...
Mastadenovirus (genus), human adenovirus (species). The GMO is a replication incompetent recombinant adenovirus (human serotype 5) containing the human gene for interleukin-12 (referred to as Adv/IL-12) ...
The Falcon Company was established in the year 1977; however, it wasnt until the year 2001 that the corporation began developing products for airsoft. The name Falcon was created after the companys I.P.S.C. Team called Chan Chun. Falcon Products are more symbolic for the I.P.S.C. fast draw set of guns. Falcon products have been used by multiple I.P.S.C teams in different countries demanding the most performance from their airsoft gun.
Molecular model of the fibre knob protein from an Adenovirus complexed with its human cellular receptor, the coxsackie and adenovirus receptor (CAR). The binding of the fibre knob protein to CAR allows the virus entry to the cell. - Stock Image C025/1656
Family Rudiviridae Unassigned families Family Adenoviridae-includes viruses which cause human adenovirus infection Family ... The families Adenoviridae and Tectiviridae appear to be related structurally. Baculoviruses evolved from the nudiviruses 310 ... Phylogenetic analysis of these genes places the adenoviruses (Adenoviridae), bacteriophages (Caudovirales) and the plant and ... Some have circular genomes (Baculoviridae, Papovaviridae and Polydnaviridae) while others have linear genomes (Adenoviridae, ...
InfectionsEdit. Main article: Adenovirus infection. Most infections with adenovirus result in infections of the upper ... Type 1 infection can also cause respiratory and eye infections. CAdV-1 also affects foxes (Vulpes vulpes, Vulpes lagopus) and ... and-rarely-even previously healthy people can die of these infections.[24] This may be because sometimes adenoviral infection ... Infection, Genetics and Evolution. 8 (3): 267-85. doi:10.1016/j.meegid.2008.01.002. PMID 18295550.. ...
usually mild respiratory, gastrointestinal and eye infections. serotypes 3, 5 and 7: lower respiratory tract infections. ... Mastadenovirus is a genus of viruses, in the family Adenoviridae. Human, mammals, and vertebrates serve as natural hosts. There ... very common human infection, estimated to be responsible for between 2% and 5% of all respiratory infections. ... serotype 14: can cause potentially fatal adenovirus infections. Canine adenovirus 1 (CAdV-1) can lead to death in puppies, or ...
Infection usually results in disease of the gastrointestinal or respiratory tract. Infection may also cause ocular or ... Bovine Adenovirus, also known as BAdV, is a member of the Adenoviridae family that causes disease in cattle. There are 10 ... However, infection may not always result in disease as the virus can be isolated in healthy cattle. Once infected, the cattle ... Signs may worsen if a secondary infection occurs. The classical signs of a generalised disease, such as pyrexia, weight loss, ...
Enveloped viruses can cause persistent infections. Classes of enveloped viruses that contain human pathogens: Herpesviruses ... Adenoviridae Papillomaviridae Picornaviridae Bacterial capsule Cell envelope "CHAPTER #11: VIRUSES". Retrieved 2008-11-07. "The ...
Proper infection and production of progeny requires that the cell be in replication, as it is during replication that the ... Examples include Herpesviridae, Adenoviridae, and Papovaviridae. There is only one well-studied example in which a class 1 ...
Infection is often subclinical, and when clinical signs are seen they are mild and short-lived. Gastrointestinal signs such as ... Porcine adenovirus (aka pADV 1-5 or pADV A-C) is a member of the adenoviridae family. It causes gastrointestinal disease in ... Respiratory signs such as coughing can be seen if the infection is part of a mutlifactorial respiratory disease complex. ... Adenoviridae Bovine adenovirus Porcine Adenovirus, reviewed and published by WikiVet at http://en.wikivet.net/Porcine_ ...
Even where an Agamid shows no signs of infection, many are believed to be sub-clinically infected, or carriers of the virus. ... Agamid adenovirus (Agamid AdV1) is a type of virus in the Adenoviridae family. The virus is widespread in captive populations ... It is probable that there is a relationship between dose of infection and clinical disease. Coinfections with other agents such ... Agamid Adenovirus is becoming widespread in the United States, with several breeders admitting infection and shutting down ...
Most infections with adenovirus result in infections of the upper respiratory tract. Adenovirus infections often show up as ... Type 1 infection can also cause respiratory and eye infections. Canine adenovirus 2 (CAdV-2) is one of the potential causes of ... Humans infected with adenoviruses display a wide range of responses, from no symptoms at all to the severe infections typical ... There are no antiviral drugs to treat adenoviral infections, so treatment is largely directed at the symptoms (such as ...
Unsurprisingly, sialic acids also play an important role in several human viral infections. The influenza viruses have ... Many viruses such as some adenoviruses (Adenoviridae), rotaviruses (Reoviridae) and influenza viruses (Orthomyxoviridae) can ...
For example, infection of mesenteric lymph glands of mice with Yersinia can clear the way for continuing infection of these ... Pathogenic viruses are diseases mainly of the families of: Adenoviridae, Picornaviridae, Herpesviridae, Hepadnaviridae, ... Infection with many pathogens can be prevented by immunization. A small amount of pathogens are used in vaccines to make ... A class of bacteria without cell walls is mycoplasma (a cause of lung infections). A class of bacteria which must live within ...
... or yeast infections. Most antibiotics that function on bacterial pathogens cannot be used to treat fungal infections because ... Pathogenic viruses are mainly those of the families of: Adenoviridae, Picornaviridae, Herpesviridae, Hepadnaviridae, ... Life-threatening fungal infections in humans most often occur in immunocompromised patients or vulnerable people with a ... Today, while many medical advances have been made to safeguard against infection by pathogens, through the use of vaccination, ...
Laboratory investigation may be useful in diagnosing associated bacterial infections, however. Viral infections are commonly of ... There are five double-stranded DNA families: three are non enveloped (Adenoviridae, Papillomaviridae and Polyomaviridae) and ... A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus ... [email protected] List of latent human viral infections Pathogenic bacteria Taylor, M.P.; Kobiler, O.; Enquist, L. W. (2012). " ...
Treatment is supportive and consists of antibiotics to prevent secondary infections, anticonvulsants for seizures, and ... Animal adenoviridae explained. ...
... is an acute liver infection in dogs caused by canine adenovirus type-1 (CAV-1). CAV-1 also causes ... Carter, G.R.; Wise, D.J. (2006). "Adenoviridae". A Concise Review of Veterinary Virology. Retrieved 2006-06-10. Ettinger, ... CAV-2 is one of the causes of respiratory infections in dogs, but it is similar enough to CAV-1 that vaccine for one creates ...
It is usually caused by infection with bacteria. The bacterial infection is often sexually transmitted, but not in every ... Other causes include: Adenoviridae Uropathogenic Escherichia coli (UPEC) Herpes simplex Cytomegalovirus Mycoplasma genitalium ... The physician sometimes performs a digital rectal examination to inspect the prostate gland for swelling or infection.[medical ... "Sexually transmitted infections and prostate cancer risk: A systematic review and meta-analysis". Cancer Epidemiology. 38 (4): ...
Viral infections weaken the immune system, making the body more susceptible to bacterial infection (including bacterial ... and adenoviridae, mumps and enterovirus can also cause pneumonia. Another cause of CAP in this group is Chlamydia trachomatis, ... Infants can acquire lung infections before birth by breathing infected amniotic fluid or through a blood-borne infection which ... CAP's symptoms are the result of lung infection by microorganisms and the immune system's response to the infection. Mechanisms ...
The infection may last from a few to ten days. The cough may persist for several weeks afterward with the total duration of ... In addition, bronchitis caused by Adenoviridae may cause systemic and gastrointestinal symptoms as well. However, the coughs ... Although infection is not the reason or cause of chronic bronchitis, it is seen to aid in sustaining the bronchitis. A physical ... In more than 90% of cases the cause is a viral infection. These viruses may be spread through the air when people cough or by ...
Adenoviridae Oncolytic adenovirus Lowe, SW; Ruley, HE (1993). "Stabilization of the p53 tumor suppressor is induced by ... White, E; Cuconati, A (2002). "Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection". Genes & ...
Breuil, G., Bonami, J.R., Pepin, J.F., and Pichot, Y. (1991). Viral infection (picorna-like virus) associated with mass ... nonenveloped: Adenoviridae. *Papillomaviridae. *Papovaviridae (obsolete). *Polyomaviridae. *genera: Rhizidiovirus. * ... Mechanisms of Capsid Assembly and Viral Infection. PLoS Pathogens 11(10), e1005203. ...
For example, infection of mesenteric lymph glands of mice with Yersinia can clear the way for continuing infection of these ... Pathogenic viruses are diseases mainly of the families of: Adenoviridae, Picornaviridae, Herpesviridae, Hepadnaviridae, ... Hygiene is critical for the prevention of infection by pathogens. Sexual interactions[edit]. Many pathogens are capable of ... Infection with many pathogens can be prevented by immunization. A small amount of pathogens are used in vaccines to make ...
Infections are normally subclinical, however clinical disease can occur - especially in young birds as maternal antibody levels ... Group: dsDNA Order: Unassigned Family: Adenoviridae Genus: Aviadenovirus Falcon aviadenovirus A Fowl aviadenovirus A Fowl ... Adenovirus Taxonomy 2005 Diagnosis of Adenovirus Infections in Psittacine Birds by DNA in situ Hybridization Viralzone: ... Adenovirus infection may infect other organs, causing a splenitis, inclusion body hepatitis, bronchitis, pulmonary congestion ...
Satellites depend on co-infection of a host cell with a helper virus for productive multiplication. Their nucleic acids have ... Family Adenoviridae (252 capsomeres) Family Papiloviridae (72 capsomeres) Family Paroviridae (32 capsomeres) Family ...
The presence of IgM in the blood of the host is used to test for acute infection, whereas IgG indicates an infection sometime ... Vaccination is a cheap and effective way of preventing infections by viruses. Vaccines were used to prevent viral infections ... Smallpox infections have been eradicated.[196] Vaccines are available to prevent over thirteen viral infections of humans,[197] ... Hepatitis viruses can develop into a chronic viral infection that leads to liver cancer.[179][180] Infection by human T- ...
May 17, 2007, Science Daily: Herpes infection might have an up side Citat: "...U.S. medical scientists say a herpes virus ... Adenoviridae. *Herpesviridae (skoldkopper, Epstein-Barr virus og mononukleose). *Mimiviridae Langkodede vira med tykke skaller ... infection has an unexpected up side, at least in mice, since it protects them against bacterial infections..." ... Hantaviral Proteins: Structure, Functions, and Role in Hantavirus Infection. Frontiers in Microbiology ...
Feline leukemia virus and Feline immunodeficiency virus infections are treated with biologics, including the only ... At that point, the infection will persist indefinitely. In most viruses, DNA is transcribed into RNA, and then RNA is ... As a result, cells such as neurons are very resistant to infection and transduction by retroviruses. This gives rise to a ... Antiretroviral drugs are medications for the treatment of infection by retroviruses, primarily HIV. Different classes of ...
What is Adenoviridae infections? Meaning of Adenoviridae infections medical term. What does Adenoviridae infections mean? ... Looking for online definition of Adenoviridae infections in the Medical Dictionary? Adenoviridae infections explanation free. ... Adenoviridae. (redirected from Adenoviridae infections). Also found in: Encyclopedia. Ad·e·no·vi·ri·dae. (adĕ-nō-viri-dē), A ... Adenoviridae infections , definition of Adenoviridae infections by Medical dictionary https://medical-dictionary. ...
Learn more about viral infections and their symptoms. ... Viruses cause familiar infections such as the common cold, but ... ClinicalTrials.gov: Adenoviridae Infections (National Institutes of Health) * ClinicalTrials.gov: Coxsackievirus Infections ( ... Antibiotics do not work for viral infections. There are antiviral medicines to treat some viral infections. Vaccines can help ... Viral Infections: How Do They Differ? (Mayo Foundation for Medical Education and Research) Also in Spanish ...
DNA Virus Infections. Virus Diseases. Adenoviridae Infections. Carcinoma. Carcinoma, Hepatocellular. Neoplasms, Glandular and ... Any active clinically serious infections (, grade 2 NCI-CTCAE ver 3.0). *HIV infection or AIDS-related illness or serious acute ...
Infection. Communicable Diseases. Adenoviridae Infections. DNA Virus Infections. Virus Diseases. To Top ... After receiving a cord blood transplant, they are at risk of infections until a new immune system to fight infections grows ... after a viral infection in the post-transplant period. In this study we are trying to prevent or treat viral infections by ... can prevent patients from getting an infection. EBV, AdV and CMV are viruses that can cause serious life-threatening infections ...
Urinary Tract Infections. Meningitis. Respiratory Tract Infections. Retinitis. Adenoviridae Infections. Angina, Stable. Herpes ... Infection Inflammation Inflammatory Conditions Influenza Intra-abdominal Infections Lower Respiratory Tract Infections ... Bone and Joint Infections Brain Swelling Central Nervous System Infections Convulsions Cytomegalovirus Retinitis Early-onset ... Infection. Communicable Diseases. Hypertension. Schizophrenia. Inflammation. Pneumonia. Epilepsy. Migraine Disorders. Bipolar ...
Infection. Communicable Diseases. Adenoviridae Infections. DNA Virus Infections. Virus Diseases. To Top ... for the treatment of AdV infection detected during asymptomatic AdV viremia or during symptomatic AdV infection. After ... in the Treatment of Early Versus Late Adenovirus Infection (CMX001 Adv). The safety and scientific validity of this study is ... AdV infection to the mortality at Week 24 for subjects treated with BCV during symptomatic or late AdV disease [ Time Frame: ...
HIV Infections. Adenoviridae Infections. Lentivirus Infections. Retroviridae Infections. RNA Virus Infections. Virus Diseases. ...
2. To compare the incidence of treatment emergent dsDNA viral infections (other than those caused by AdV), in subjects treated ...
5. Acute upper respiratory infection. 6. Addiction. 7. Adenoiditis. 8. Adenoviridae Infections. 9. Adenovirus infection in ...
5. Acute upper respiratory infection. 6. Addiction. 7. Adenoiditis. 8. Adenoviridae Infections. 9. Adenovirus infection in ...
3. Adenophorea Infections. 4. Adenoviridae Infections. 5. Adenovirus infection in immunocompromised patients. 6. Allergies. 7. ...
List of 76 causes for Ear canal infection and Ear infection, alternative diagnoses, rare causes, misdiagnoses, patient stories ... 4. Acute upper respiratory infection. 5. Adenoiditis. 6. Adenoviridae Infections. 7. Adenovirus infection in immunocompromised ... Ear canal infection and Ear infection. *Ear canal infection AND Ear infection - Causes of All Symptoms *Ear canal infection OR ... Ear canal infection: Remove a symptom Ear infection:*76 causes: Ear infection *Introduction: Ear infection *Ear infection: Add ...
Adenoviridae Infections. Infection with a virus from the Adenoviridae family. The most common sites for infection are membrane ... 7. Acute upper respiratory infection. Upper respiratory tract infections, are the illnesses caused by an acute infection which ... The infection may result in a range of symptoms depending on the particular v...more ». More causes » , Show All 768 Causes , ... Infection of the appendix...more ». 4. Acute Bronchitis. Respiratory inflammation of the bronchi leading to the lungs...more » ...
6. Acute upper respiratory infection. 7. Adenoviridae Infections. 8. Adenovirus infection in immunocompromised patients. 9. ... 2. Actinomycetales infection. 3. Acute Renal Failure. 4. Acute Sinusitis. 5. Acute mountain sickness. ...
List of causes of Calcaneal bone redness and Infection, alternative diagnoses, rare causes, misdiagnoses, patient stories, and ... Adenoviridae Infections. 44. Adenovirus infection in immunocompromised patients. 45. Adenovirus-related Cold. 46. Adenoviruses ... Shigella boydii infection. 1071. Shigella dysenteriae infection. 1072. Shigella flexneri. 1073. Shigella flexneri infection. ... Gnathostoma Infection. 466. Gnathostoma hispidum infection. 467. Gnathostoma spinigerum infection. 468. Gonococcal urethritis. ...
5. Acute upper respiratory infection. 6. Addiction. 7. Adenoiditis. 8. Adenoviridae Infections. 9. Adenovirus infection in ...
RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and ... HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE ... PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.. Meningitis, ...
RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and ... HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal ... RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS. ...
RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and ... HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal ... RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS. ...
RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and ... HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS. ... TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE ...
Diseases : Adenoviridae Infections. Pharmacological Actions : Antiviral Agents. [+] Black tea extract has the potential to be ... Honey and green/black tea intake is associated with a reduced prevalence of H. pylori infections.Mar 05, 2015. ... Theaflavin digallate has potential to be a promising natural and affordable remedy against herpes simplex viral infections.May ... Gargling with tea and its ingredients may have a preventative effect for influenza infection. Dec 31, 2015. ...
HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary ...
RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and ... HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal ... RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS. ...
... acute HIV infection is critical to understanding subtype-specific pathophysiologic differences, since u... ... RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and ... HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal ...
RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and ... HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal ... RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS. ...
  • Thus, chronic infection of lymphoid cells by some adenoviruses is maintained by at least two mechanisms: cell-to-cell spread of virus in the absence of antibody and intracellular persistence of infectious virus in the presence of antibody. (nih.gov)
  • These studies revealed that 31.7% of the hospital admissions in such patients were complicated by symptomatic infection with enteric adenoviruses. (nih.gov)
  • In addition infections with enteric adenoviruses in the infants with necrotizing enterocolitis and ostomies were associated with a marked increase in length of hospitalization as compared to uninfected infants with similar underlying gastrointestinal pathology. (nih.gov)
  • Human adenoviruses (HAdVs) can cause a wide spectrum of clinical illness, ranging from asymptomatic infections to severe illnesses and death. (cdc.gov)
  • Avian Adenoviruses, reviewed and published by WikiVet at http://en.wikivet.net/Avian_Adenoviruses, accessed 18/08/2011. (wikipedia.org)
  • Respiratory infections: Sputum or throat swabs c. (issuu.com)
  • There are currently 25 species in this genus, including the type species Human mastadenovirus C. Diseases associated with this genus include: very common human infection, estimated to be responsible for between 2% and 5% of all respiratory infections. (wikipedia.org)
  • in humans, more than 50 distinct adenoviral serotypes have been found to cause a wide range of illnesses, from mild respiratory infections in young children (known as the common cold) to life-threatening multi-organ disease in people with a weakened immune system. (wikipedia.org)
  • CAV-2 is one of the causes of respiratory infections in dogs, but it is similar enough to CAV-1 that vaccine for one creates immunity for both. (wikipedia.org)
  • In contrast to that observed in endothelial cells, the Ad vector-mediated induction of gene expression was not found following Ad vector infection of primary human dermal fibroblasts or human alveolar macrophages. (elsevier.com)
  • Investigators will test to see if blood cells from donor that have been grown in a special way, can prevent patients from getting an infection. (clinicaltrials.gov)
  • Some of these studies have shown a positive therapeutic effect in patients receiving the CTLs (specially trained T cells) after a viral infection in the post-transplant period. (clinicaltrials.gov)
  • They have used T cells made in this way from the blood of donors to prevent infections in patients who are getting a bone marrow or blood stem cell transplant but this will be the first time investigators make them from cord blood. (clinicaltrials.gov)
  • The purpose of this study is to determine the efficacy of ertapenem sodium (Invanz) in treatment of complicated urinary tract infections with respect to the proportion of patients with a f. (bioportfolio.com)
  • A multicenter study to evaluate the effectiveness of ertapenem compared to ceftriaxone/metronidazole in treating certain abdominal infections that require surgery in adult patients. (bioportfolio.com)
  • Necrotizing soft-tissue infections (NSTIs) result in significant morbidity and mortality rates, with as many as 76% of patients dying during their index admission. (bioportfolio.com)
  • mircoRNA-3162-3p is a potential biomarker to identify new infections in HIV-1-infected patients. (bioportfolio.com)
  • These studies demonstrate that enteric adenovirus infections are major causes of morbidity in hospitalized patients who have of morbidity in hospitalized patients who have undergone ileostomy or colostomy procedures for necrotizing enterocolitis and that the prevention of enteric adenovirus infections might result in a significant improvement in the hospital care of infants with these conditions. (nih.gov)
  • CMV can also cause serious infections in patients with weak or suppressed immune systems. (clinicaltrials.gov)
  • Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 patients. (northwestern.edu)
  • This is particularly true for adenoviral infections as they also have a distinct clinical picture in immunocompromised patients when compared to immune competent patients. (elsevier.com)
  • Other causes include: Adenoviridae Uropathogenic Escherichia coli (UPEC) Herpes simplex Cytomegalovirus Mycoplasma genitalium Reactive arthritis Trichomonas vaginalis Ureaplasma urealyticum Methicillin-resistant Staphylococcus aureus Group B streptococcus In female patients, urethritis can be caused by pelvic inflammatory disease. (wikipedia.org)
  • A full spectrum of microorganisms is responsible for CAP in adults, and patients with certain risk factors are more susceptible to infections of certain groups of microorganisms. (wikipedia.org)
  • Some patients have an underlying problem which increases their risk of infection. (wikipedia.org)
  • A fixed-ratio combination of amoxicillin trihydrate (see AMOXICILLIN), an aminopenicillin, and potassium clavulanate (see CLAVULANIC ACID), a beta-lactamase inhibitor, used to treat a broad-spectrum of bacterial infections, especially resistant strains. (bioportfolio.com)
  • Laboratory investigation may be useful in diagnosing associated bacterial infections, however. (wikipedia.org)
  • CAVs belong to the genus Mastadenovirus of the family Adenoviridae. (hindawi.com)
  • A class of bacteria which must live within other cells (obligate intracellular parasitic) is chlamydia (genus), the world leader in causing sexually transmitted infection (STI). (wikipedia.org)
  • The purpose of this multicentre prospective trial is to determine the incidence and risk factors for surgical wound infections. (bioportfolio.com)
  • To determine the incidence of adenovirus infection in a tropical climate, stools were collected from children under age 7 during a 1-year period at an outpatient clinic in Bangkok, Thailand. (umassmed.edu)
  • Modeling studies suggest that if only 8% of these individuals with latent TB infection (LTBI) were treated annually, overall global incidence would be 14-fold lower by 2050 compared to incidence in 2013, even in the absence of additional TB control measures. (asmscience.org)
  • Pathogenicity is also distinct from the transmissibility of the virus, which quantifies the risk of infection. (wikipedia.org)
  • In this study, investigators are trying to see if infusion of 'm-CTLs' will prevent or treat cytomegalovirus (CMV), Epstein Barr Virus (EBV) and adenovirus (AdV) reactivation or infection after cord blood transplant. (clinicaltrials.gov)
  • The Investigators want to see if they can use a kind of white blood cell called T lymphocytes (or T cells) to prevent and treat adenovirus, CMV, EBV, BKV and HHV6 in the early stages of reactivation or infection. (clinicaltrials.gov)
  • The purpose of this study is to demonstrate that MK0826 is comparable to Meropenem in the treatment of complicated Urinary Tract Infections (UTIs) in adults. (bioportfolio.com)
  • The successful treatment of HIV infection relies on the use of combinations of antiretroviral therapy (cART) to achieve durable viral suppression and to minimize the emergence of resistant. (bioportfolio.com)
  • we successfully validated these predictions in an ensuing explicit test study.We conclude that integrated computational and experimental analysis of combinatorial therapy provides a useful means to identify treatment/infection protocols that yield clinically significant oncolysis. (nih.gov)
  • We investigated combinatorial treatment strategies using a mathematical model that predicts the impact of MEK inhibition on tumor cell proliferation, ONYX-015 infection, and oncolysis. (nih.gov)
  • We conclude that integrated computational and experimental analysis of combinatorial therapy provides a useful means to identify treatment/infection protocols that yield clinically significant oncolysis. (nih.gov)
  • Efficacy of treatment/infection correlates to cell density at the time of infection.HCT116 cells were seeded at 2e4 cells/well (low density) or 1e5 cells/well (high density) in 96-well plates. (nih.gov)
  • To further investigate conditions that give rise to increased therapeutic efficacy, we correlated simulated cell death profiles with (i) cell confluency at the time of treatment, (ii) the proportion of cells in CI1040 mediated G1 cell cycle arrest at the time of infection, and (iii) cell confluency at the time of infection. (nih.gov)
  • Adenovirus infections also have the additional challenge that its treatment, cidofovir, has associated toxicities that can delay its administration. (elsevier.com)
  • Treatment of respiratory virus infections. (nih.gov)
  • Antibiotic treatment may also be indicated to prevent secondary infection. (wikipedia.org)
  • Treatment is supportive and consists of antibiotics to prevent secondary infections, anticonvulsants for seizures, and intravenus fluids to prevent dehydration. (wikipedia.org)
  • Identifying people at risk for infection by these organisms aids in appropriate treatment. (wikipedia.org)
  • In a previous trial of antiretroviral therapy (ART) involving pregnant women with human immunodeficiency virus (HIV) infection, those randomly assigned to receive tenofovir, emtricitabine, and ritonav. (bioportfolio.com)
  • Chronic infection with adenovirus types 5 and 6 was established in primary mononuclear leukocytes from human umbilical cord blood and in Epstein-Barr virus (EBV)-transformed B lymphocytes from human umbilical cord blood and from woolly monkey blood. (nih.gov)
  • Infection in cultures of EBV-transformed lymphocytes from woolly monkey blood was obliterated by exposure to antibody, but EBV-transformed lymphocytes from human umbilical cord blood contained small amounts of virus for prolonged periods that restored infection in the culture when antibody was removed. (nih.gov)
  • To date, limited studies have been done to determine the prevalence of adenovirus infection in non-human primates with the goal of developing a non-human primate model that can be used to study the mechanisms of infection. (biomedsearch.com)
  • DESIGN: A prospective study to investigate the prevalence of enteric andenovirus infection in captive non-human primates maintained in a colony. (biomedsearch.com)
  • CONCLUSION: The results of this study indicate that adenovirus infection is prevalent among non-human primates in Kenya. (biomedsearch.com)
  • We found that following infection, human airway epithelia first released adenovirus to the basolateral surface. (nih.gov)