Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Adenoviridae Infections: Virus diseases caused by the ADENOVIRIDAE.Dictionaries, ChemicalAdenoviridae: A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Parainfluenza Virus 2, Human: A species of RUBULAVIRUS associated particularly with acute laryngotracheitis (CROUP) in children aged 6 months to 3 years.Parainfluenza Virus 3, Human: A species of RESPIROVIRUS frequently isolated from small children with pharyngitis, bronchitis, and pneumonia.Respirovirus: A genus of the family PARAMYXOVIRIDAE (subfamily PARAMYXOVIRINAE) where all the virions have both HEMAGGLUTININ and NEURAMINIDASE activities and encode a non-structural C protein. SENDAI VIRUS is the type species.Parainfluenza Virus 1, Human: A species of RESPIROVIRUS also called hemadsorption virus 2 (HA2), which causes laryngotracheitis in humans, especially children.Vocabulary, Controlled: A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)Parainfluenza Virus 3, Bovine: A species of RESPIROVIRUS, subfamily PARAMYXOVIRINAE, most often seen in conjunction with a secondary infection of MANNHEIMIA HAEMOLYTICA resulting in pneumonic pasteurellosis (PASTEURELLOSIS, PNEUMONIC).Parainfluenza Virus 5: A species of RUBULAVIRUS originally isolated from cultured primary monkey cells. Its natural host is the DOG in which it causes kennel cough, but it can also infect humans.United States Dept. of Health and Human Services: A cabinet department in the Executive Branch of the United States Government concerned with administering those agencies and offices having programs pertaining to health and human services.Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.National Institutes of Health (U.S.): An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.Anti-HIV Agents: Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.CD4 Lymphocyte Count: The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.Benzoxazines: OXAZINES with a fused BENZENE ring.Nelfinavir: A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Nucleic Acids: High molecular weight polymers containing a mixture of purine and pyrimidine nucleotides chained together by ribose or deoxyribose linkages.Nucleic Acid Hybridization: Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)Illusions: The misinterpretation of a real external, sensory experience.DNA Probes: Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Oligonucleotide Probes: Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Indigo Carmine: Indolesulfonic acid used as a dye in renal function testing for the detection of nitrates and chlorates, and in the testing of milk.BooksClassification: The systematic arrangement of entities in any field into categories classes based on common characteristics such as properties, morphology, subject matter, etc.Red Cross: International collective of humanitarian organizations led by volunteers and guided by its Congressional Charter and the Fundamental Principles of the International Red Cross Movement, to provide relief to victims of disaster and help people prevent, prepare for, and respond to emergencies.Vanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).Paeonia: A plant genus of the family Paeoniaceae, order Dilleniales, subclass Dilleniidae, class Magnoliopsida. These perennial herbs are up to 2 m (6') tall. Leaves are alternate and are divided into three lobes, each lobe being further divided into three smaller lobes. The large flowers are symmetrical, bisexual, have 5 sepals, 5 petals (sometimes 10), and many stamens.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Gabon: A republic in west equatorial Africa, south of CAMEROON and west of the CONGO. Its capital is Libreville.Filoviridae: A family of RNA viruses, of the order MONONEGAVIRALES, containing filamentous virions. Although they resemble RHABDOVIRIDAE in possessing helical nucleocapsids, Filoviridae differ in the length and degree of branching in their virions. There are two genera: EBOLAVIRUS and MARBURGVIRUS.Africa, Central: The geographical area of Africa comprising CAMEROON; CENTRAL AFRICAN REPUBLIC; CHAD; CONGO; EQUATORIAL GUINEA; GABON; and DEMOCRATIC REPUBLIC OF THE CONGO.Filoviridae Infections: Infections with viruses of the family FILOVIRIDAE. The infections in humans consist of a variety of clinically similar viral hemorrhagic fevers but the natural reservoir host is unknown.BangladeshHemorrhagic Fever, Ebola: A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.AfricaMarburgvirus: A genus in the family FILOVIRIDAE consisting of one species (Lake Victoria marburgvirus) with several strains. The genus shows no antigenic cross-reactivity with EBOLAVIRUS.Ebolavirus: A genus in the family FILOVIRIDAE consisting of several distinct species of Ebolavirus, each containing separate strains. These viruses cause outbreaks of a contagious, hemorrhagic disease (HEMORRHAGIC FEVER, EBOLA) in humans, usually with high mortality.South Africa: A republic in southern Africa, the southernmost part of Africa. It has three capitals: Pretoria (administrative), Cape Town (legislative), and Bloemfontein (judicial). Officially the Republic of South Africa since 1960, it was called the Union of South Africa 1910-1960.Pneumonia, Viral: Inflammation of the lung parenchyma that is caused by a viral infection.Pneumonia: Infection of the lung often accompanied by inflammation.Pneumonia, Bacterial: Inflammation of the lung parenchyma that is caused by bacterial infections.Paramyxoviridae Infections: Infections with viruses of the family PARAMYXOVIRIDAE. This includes MORBILLIVIRUS INFECTIONS; RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS.Influenza, Human: An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.Influenza A Virus, H1N1 Subtype: A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Orthomyxoviridae Infections: Virus diseases caused by the ORTHOMYXOVIRIDAE.Pneumonia, Pneumococcal: A febrile disease caused by STREPTOCOCCUS PNEUMONIAE.
(1/9136) Adenoviral gene transfer into the normal and injured spinal cord: enhanced transgene stability by combined administration of temperature-sensitive virus and transient immune blockade.

This study characterized gene transfer into both normal and injured adult rat dorsal spinal cord using first (E1-/E3-) or second (E1-/E2A125/E3-, temperature-sensitive; ts) generation of replication-defective adenoviral (Ad) vectors. A novel immunosuppressive regimen aimed at blocking CD4/CD45 lymphocytic receptors was tested for improving transgene persistence. In addition, the effect of gene transfer on nociception was also evaluated. Seven days after treatment, numerous LacZ-positive cells were observed after transfection with either viral vector. By 21 days after transfection, beta-galactosidase staining was reduced and suggestive of ongoing cytopathology in both Ad-treated groups, despite the fact that the immunogenicity of LacZ/Adts appeared less when compared with that elicited by the LacZ/Ad vector. In contrast, immunosuppressed animals showed a significant (P < or = 0.05) increase in the number of LacZ-positive cells not displaying cytopathology. In these animals, a concomitant reduction in numbers of macrophages/microglia and CD4 and CD8 lymphocytes was observed. Only animals that received LacZ/Adts and immunosuppression showed transgene expression after 60 days. Similar results were observed in animals in which the L4-L5 dorsal roots were lesioned before transfection. Gene transfer into the dorsal spinal cord did not affect nociception, independent of the adenovirus vector. These results indicate that immune blockade of the CD4/CD45 lymphocytic receptors enhanced transgene stability in adult animals with normal or injured spinal cords and that persistent transgene expression in the spinal cord does not interfere with normal neural function.  (+info)

(2/9136) Definition of a major p53 binding site on Ad2E1B58K protein and a possible nuclear localization signal on the Ad12E1B54K protein.

Previous studies have established that adenovirus 2/5 early region 1B (Ad E1B) 58K protein binds p53 strongly and co-localizes with it to cytoplasmic dense bodies whilst the homologous Ad12E1B54K protein binds only weakly and co-localizes primarily to the nucleus in Ad12E1 transformed cells. We have used these properties of the E1B proteins from different viral serotypes to map the p53 binding site on the Ad2/5 protein. A set of chimaeric genes was constructed containing different proportions of the Ad12 and Ad2E1B DNA. These, together with Ad12E1A and E1B19K DNA, were transfected into baby rat kidney cells and transformed lines isolated. From an examination of the properties of these Ad12/Ad2E1B fusion proteins in co-immunoprecipitation and subcellular localization experiments it has been concluded that the p53 binding site on Ad2E1B58K protein lies between amino acids 216 and 235 and that the homologous region on Ad12E1B54K protein also binds p53. In addition, a unique nuclear localization signal is located on Ad12E1B54K between residues 228 and 239. We suggest that primary structure differences in these regions of the Ad2 and Ad12E1B proteins are responsible for the different subcellular localizations in AdE1 transformants.  (+info)

(3/9136) Inducible genetic suppression of neuronal excitability.

Graded, reversible suppression of neuronal excitability represents a logical goal of therapy for epilepsy and intractable pain. To achieve such suppression, we have developed the means to transfer "electrical silencing" genes into neurons with sensitive control of transgene expression. An ecdysone-inducible promoter drives the expression of inwardly rectifying potassium channels in polycistronic adenoviral vectors. Infection of superior cervical ganglion neurons did not affect normal electrical activity but suppressed excitability after the induction of gene expression. These experiments demonstrate the feasibility of controlled ion channel expression after somatic gene transfer into neurons and serve as the prototype for a novel generalizable approach to modulate excitability.  (+info)

(4/9136) Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor.

We have shown previously that human apolipoprotein (apo)C1 transgenic mice exhibit hyperlipidaemia, due primarily to an impaired clearance of very-low-density lipoprotein (VLDL) particles from the circulation. In the absence of at least the low-density-lipoprotein receptor (LDLR), it was shown that APOC1 overexpression in transgenic mice inhibited the hepatic uptake of VLDL via the LDLR-related protein. In the present study, we have now examined the effect of apoC1 on the binding of lipoproteins to both the VLDL receptor (VLDLR) and the LDLR. The binding specificity of the VLDLR and LDLR for apoC1-enriched lipoprotein particles was examined in vivo through adenovirus-mediated gene transfer of the VLDLR and the LDLR [giving rise to adenovirus-containing (Ad)-VLDLR and Ad-LDLR respectively] in APOC1 transgenic mice, LDLR-deficient (LDLR-/-) mice and wild-type mice. Remarkably, Ad-VLDLR treatment did not reduce hyperlipidaemia in transgenic mice overexpressing human APOC1, irrespective of both the level of transgenic expression and the presence of the LDLR, whereas Ad-VLDLR treatment did reverse hyperlipidaemia in LDLR-/- and wild-type mice. On the other hand, Ad-LDLR treatment strongly decreased plasma lipid levels in these APOC1 transgenic mice. These results suggest that apoC1 inhibits the clearance of lipoprotein particles via the VLDLR, but not via the LDLR. This hypothesis is corroborated by in vitro binding studies. Chinese hamster ovary (CHO) cells expressing the VLDLR (CHO-VLDLR) or LDLR (CHO-LDLR) bound less APOC1 transgenic VLDL than wild-type VLDL. Intriguingly, however, enrichment with apoE enhanced dose-dependently the binding of wild-type VLDL to CHO-VLDLR cells (up to 5-fold), whereas apoE did not enhance the binding of APOC1 transgenic VLDL to these cells. In contrast, for binding to CHO-LDLR cells, both wild-type and APOC1 transgenic VLDL were stimulated upon enrichment with apoE. From these studies, we conclude that apoC1 specifically inhibits the apoE-mediated binding of triacylglycerol-rich lipoprotein particles to the VLDLR, whereas apoC1-enriched lipoproteins can still bind to the LDLR. The variability in specificity of these lipoprotein receptors for apoC1-containing lipoprotein particles provides further evidence for a regulatory role of apoC1 in the delivery of lipoprotein constituents to different tissues on which these receptors are located.  (+info)

(5/9136) Adenovirus mediated p53 tumour suppressor gene therapy for human gastric cancer cells in vitro and in vivo.

BACKGROUND/AIMS: Gastric cancer is one of the most prevalent forms of cancer in East Asia. Point mutation of the p53 gene has been reported in more than 60% of cases of gastric cancer and can lead to genetic instability and uncontrolled cell proliferation. The purpose of this investigation was to evaluate the potential of p53 gene therapy for gastric cancer. METHODS: The responses of human gastric cancer cell lines, MKN1, MKN7, MKN28, MKN45, and TMK-1, to recombinant adenoviruses encoding wild type p53 (AdCAp53) were analysed in vitro. The efficacy of the AdCAp53 treatment for MKN1 and MKN45 subcutaneous tumours in nude mice was assessed in vivo. RESULTS: p53-specific growth inhibition was observed in vitro in two of four gastric cancer cell lines with mutated p53, but not in the wild type p53 cell line. The mechanism of the killing of gastric cancer cells by AdCAp53 was found, by flow cytometric analysis and detection of DNA fragmentation, to be apoptosis. In vivo studies showed that the growth of subcutaneous tumours of p53 mutant MKN1 cells was significantly inhibited by direct injection of AdCAp53, but no significant growth inhibition was detected in the growth of p53 wild type MKN45 tumours. CONCLUSIONS: Adenovirus mediated reintroduction of wild type p53 is a potential clinical utility in gene therapy for gastric cancers.  (+info)

(6/9136) Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice.

Dopamine-deficient mice (DA-/- ), lacking tyrosine hydroxylase (TH) in dopaminergic neurons, become hypoactive and aphagic and die by 4 weeks of age. They are rescued by daily treatment with L-3,4-dihydroxyphenylalanine (L-DOPA); each dose restores dopamine (DA) and feeding for less than 24 hr. Recombinant adeno-associated viruses expressing human TH or GTP cyclohydrolase 1 (GTPCH1) were injected into the striatum of DA-/- mice. Bilateral coinjection of both viruses restored feeding behavior for several months. However, locomotor activity and coordination were partially improved. A virus expressing only TH was less effective, and one expressing GTPCH1 alone was ineffective. TH immunoreactivity and DA were detected in the ventral striatum and adjacent posterior regions of rescued mice, suggesting that these regions mediate a critical DA-dependent aspect of feeding behavior.  (+info)

(7/9136) Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF.

Diabetes is a major risk factor for coronary and peripheral artery diseases. Although diabetic patients often present with advanced forms of these diseases, it is not known whether the compensatory mechanisms to vascular ischemia are affected in this condition. Accordingly, we sought to determine whether diabetes could: 1) impair the development of new collateral vessel formation in response to tissue ischemia and 2) inhibit cytokine-induced therapeutic neovascularization. Hindlimb ischemia was created by femoral artery ligation in nonobese diabetic mice (NOD mice, n = 20) and in control C57 mice (n = 20). Hindlimb perfusion was evaluated by serial laser Doppler studies after the surgery. In NOD mice, measurement of the Doppler flow ratio between the ischemic and the normal limb indicated that restoration of perfusion in the ischemic hindlimb was significantly impaired. At day 14 after surgery, Doppler flow ratio in the NOD mice was 0.49+/-0.04 versus 0.73+/-0.06 for the C57 mice (P< or =0.005). This impairment in blood flow recovery persisted throughout the duration of the study with Doppler flow ratio values at day 35 of 0.50+/-0.05 versus 0.90+/-0.07 in the NOD and C57 mice, respectively (P< or =0.001). CD31 immunostaining confirmed the laser Doppler data by showing a significant reduction in capillary density in the NOD mice at 35 days after surgery (302+/-4 capillaries/mm2 versus 782+/-78 in C57 mice (P< or =0.005). The reduction in neovascularization in the NOD mice was the result of a lower level of vascular endothelial growth factor (VEGF) in the ischemic tissues, as assessed by Northern blot, Western blot and immunohistochemistry. The central role of VEGF was confirmed by showing that normal levels of neovascularization (compared with C57) could be achieved in NOD mice that had been supplemented for this growth factor via intramuscular injection of an adenoviral vector encoding for VEGF. We conclude that 1) diabetes impairs endogenous neovascularization of ischemic tissues; 2) the impairment in new blood vessel formation results from reduced expression of VEGF; and 3) cytokine supplementation achieved by intramuscular adeno-VEGF gene transfer restores neovascularization in a mouse model of diabetes.  (+info)

(8/9136) Adenoviral gene transfer of the human V2 vasopressin receptor improves contractile force of rat cardiomyocytes.

BACKGROUND: In congestive heart failure, high systemic levels of the hormone arginine vasopressin (AVP) result in vasoconstriction and reduced cardiac contractility. These effects are mediated by the V1 vasopressin receptor (V1R) coupled to phospholipase C beta-isoforms. The V2 vasopressin receptor (V2R), which promotes activation of the Gs/adenylyl cyclase system, is physiologically expressed in the kidney but not in the myocardium. Expression of a recombinant V2R (rV2R) in the myocardium could result in a positive inotropic effect via the endogenous high concentrations of AVP in heart failure. METHODS AND RESULTS: A recombinant adenovirus encoding the human V2R (Ad-V2R) was tested for its ability to modulate the cardiac Gs/adenylyl cyclase system and to potentiate contractile force in rat ventricular cardiomyocytes and in H9c2 cardiomyoblasts. Ad-V2R infection resulted in a virus concentration-dependent expression of the transgene and led to a marked increase in cAMP formation in rV2R-expressing cardiomyocytes after exposure to AVP. Single-cell shortening measurements showed a significant agonist-induced contraction amplitude enhancement, which was blocked by the V2R antagonist, SR 121463A. Pretreatment of Ad-V2R-infected cardiomyocytes with AVP led to desensitization of the rV2R after short-term agonist exposure but did not lead to further loss of receptor function or density after long-term agonist incubation, thus demonstrating resistance of the rV2R to downregulation. CONCLUSIONS: Adenoviral gene transfer of the V2R in cardiomyocytes can modulate the endogenous adenylyl cyclase-signal transduction cascade and can potentiate contraction amplitude in cardiomyocytes. Heterologous expression of cAMP-forming receptors in the myocardium could lead to novel strategies in congestive heart failure by bypassing the desensitized beta-adrenergic receptor signaling.  (+info)

*  Adenoviridae
Adenoviruses (members of the family Adenoviridae) are medium-sized (90-100 nm), nonenveloped (without an outer lipid bilayer) ... Group: dsDNA Order: Unassigned Family: Adenoviridae Genus: Atadenovirus Bovine atadenovirus D Duck atadenovirus A Ovine ... Adenoviridae Adenovirus Research Discussion Group USAMRMC protects Soldiers against unseen enemy 3D macromolecular structures ... Adenoviridae can be divided into five genera: Mastadenovirus, Aviadenovirus, Atadenovirus, Siadenovirus, and Ichtadenovirus. ...
*  Infectious canine hepatitis
Carter, G.R.; Wise, D.J. (2006). "Adenoviridae". A Concise Review of Veterinary Virology. Retrieved 2006-06-10. Ettinger, ...
*  DA2PPC vaccine
Animal adenoviridae explained. ...
*  Adenovirus E1B protein
Adenoviridae Oncolytic adenovirus Lowe, SW; Ruley, HE (1993). "Stabilization of the p53 tumor suppressor is induced by ...
*  Baltimore classification
Examples include Herpesviridae, Adenoviridae, and Papovaviridae. There is only one well-studied example in which a class 1 ...
*  Mastadenovirus
... is a genus of viruses, in the family Adenoviridae. Human, mammals, and vertebrates serve as natural hosts. There ... Group: dsDNA Order: Unassigned Family: Adenoviridae Genus: Mastadenovirus Bat mastadenovirus A Bat mastadenovirus B Bovine ...
*  Ichtadenovirus
... is a genus of viruses, in the family Adenoviridae. Fish serve as natural hosts. There is currently only one ... species in this genus: the type species Sturgeon ichtadenovirus A. Group: dsDNA Order: Unassigned Family: Adenoviridae Genus: ...
*  Siadenovirus
... is a genus of viruses, in the family Adenoviridae. Vertebrates serve as natural hosts. There are currently five ... species in this genus including the type species Frog siadenovirus A. Group: dsDNA Order: Unassigned Family: Adenoviridae Genus ...
*  DNA virus
The families Adenoviridae and Tectiviridae appear to be related structurally. Baculoviruses evolved from the nudiviruses 310 ... Phylogenetic analysis of these genes places the adenoviruses (Adenoviridae), bacteriophages (Caudovirales) and the plant and ... Some have circular genomes (Baculoviridae, Papovaviridae and Polydnaviridae) while others have linear genomes (Adenoviridae, ... Species of the order Herpesvirales and of the families Adenoviridae, Asfarviridae, Iridoviridae, Papillomaviridae, ...
*  Agamid adenovirus
... (Agamid AdV1) is a type of virus in the Adenoviridae family. The virus is widespread in captive populations ...
*  Acute bronchitis
In addition, bronchitis caused by Adenoviridae may cause systemic and gastrointestinal symptoms as well. However, the coughs ...
*  Porcine adenovirus
... (aka pADV 1-5 or pADV A-C) is a member of the adenoviridae family. It causes gastrointestinal disease in ... Adenoviridae Bovine adenovirus Porcine Adenovirus, reviewed and published by WikiVet at http://en.wikivet.net/Porcine_ ...
*  Bovine adenovirus
... , also known as BAdV, is a member of the Adenoviridae family that causes disease in cattle. There are 10 ...
*  Community-acquired pneumonia
... and adenoviridae, mumps and enterovirus can also cause pneumonia. Another cause of CAP in this group is Chlamydia trachomatis, ...
*  Bat adenovirus TJM
... (Bt-AdV-TJM) is a novel species of the Mastadenovirus genus of the family Adenoviridae. It is a double ...
*  Pathogen
... ic viruses are diseases mainly of the families of: Adenoviridae, Picornaviridae, Herpesviridae, Hepadnaviridae, ...
*  Viral disease
There are five double-stranded DNA families: three are non enveloped (Adenoviridae, Papillomaviridae and Polyomaviridae) and ...
*  Human pathogen
Pathogenic viruses are mainly those of the families of: Adenoviridae, Picornaviridae, Herpesviridae, Hepadnaviridae, ...
*  Penton (disambiguation)
This use of the term penton appears in the article on Adenoviridae in the description of the capsid of this family of viruses.[ ...
*  Sialic acid
Many viruses such as some adenoviruses (Adenoviridae), rotaviruses (Reoviridae) and influenza viruses (Orthomyxoviridae) can ...
*  Mating system
Examples of MR in animal viruses are described in the articles Herpes simplex virus, Influenza A virus, Adenoviridae, Simian ...
*  Viral envelope
Adenoviridae Papillomaviridae Picornaviridae Bacterial capsule Cell envelope "CHAPTER #11: VIRUSES". Retrieved 2008-11-07. "The ...
*  Viral replication
An example of a family within this classification is the Adenoviridae There is only one well-studied example in which a class 1 ...
*  Taxonomic list of viruses
Adenoviridae Genus: Atadenovirus Bovine atadenovirus D Duck atadenovirus A Ovine atadenovirus D Possum atadenovirus A Snake ...
*  Viral Bioinformatics Resource Center
Adenoviridae Asfarviridae Baculoviridae Herpesviridae Iridoviridae The VBRC database stores viral bioinformatic data on three ...
Adenoviridae - Wikipedia  Adenoviridae - Wikipedia
Classification of Adenoviridae can be complex. In humans, there are 57 accepted human adenovirus types (HAdV-1 to 57) in seven ... When not restricting the subject to human viruses, Adenoviridae can be divided into five genera: Mastadenovirus, Aviadenovirus ... Adenoviruses (members of the family Adenoviridae) are medium-sized (90-100 nm), nonenveloped (without an outer lipid bilayer) ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Adenoviridae&oldid=898892844" ...
more infohttps://en.m.wikipedia.org/wiki/Adenoviridae
Adenoviridae  Adenoviridae
Adenoviruses, family Adenoviridae. ]. (n.d.). Retrieved from https://www.shutterstock.com/image-illustration/adenoviruses- ... family-adenoviridae-their-name-derives-208224640. Health , Cold virus to aid cancer patients. (2007, January 11). Retrieved ... S. (n.d.). ViralZone: Adenoviridae. Retrieved January 30, 2017, from http://viralzone.expasy.org/all_by_species/4.html ...
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Browsing  by Subject Adenoviridae  Browsing by Subject "Adenoviridae"
Cardiovascular gene therapy is a novel approach to the treatment of diseases such as congestive heart failure (CHF). Gene transfer to the heart would allow for the replacement of defective or missing cellular proteins that ...
more infohttps://dukespace.lib.duke.edu/dspace/browse?type=subject&value=Adenoviridae
Adenoviridae - Wikipedia  Adenoviridae - Wikipedia
Adenoviruses (members of the family Adenoviridae) are medium-sized (90-100 nm), nonenveloped (without an outer lipid bilayer) ... Group: dsDNA Order: Unassigned Family: Adenoviridae Genus: Atadenovirus Bovine atadenovirus D Duck atadenovirus A Ovine ... Adenoviridae Adenovirus Research Discussion Group USAMRMC protects Soldiers against unseen enemy 3D macromolecular structures ... Adenoviridae can be divided into five genera: Mastadenovirus, Aviadenovirus, Atadenovirus, Siadenovirus, and Ichtadenovirus. ...
more infohttps://en.wikipedia.org/wiki/Adenoviridae
Adenoviridae | definition of Adenoviridae by Medical dictionary  Adenoviridae | definition of Adenoviridae by Medical dictionary
Adenoviridae explanation free. What is Adenoviridae? Meaning of Adenoviridae medical term. What does Adenoviridae mean? ... Looking for online definition of Adenoviridae in the Medical Dictionary? ... Adenoviridae. Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.. Related to Adenoviridae: adenovirus, ... Adenoviridae , definition of Adenoviridae by Medical dictionary https://medical-dictionary.thefreedictionary.com/Adenoviridae ...
more infohttps://medical-dictionary.thefreedictionary.com/Adenoviridae
Adenoviridae synonyms, Adenoviridae antonyms - FreeThesaurus.com  Adenoviridae synonyms, Adenoviridae antonyms - FreeThesaurus.com
Antonyms for Adenoviridae. 2 words related to adenovirus: parainfluenza virus, animal virus. What are synonyms for Adenoviridae ... redirected from Adenoviridae). Also found in: Dictionary, Medical, Encyclopedia, Wikipedia.. Related to Adenoviridae: ... The family Adenoviridae was verified by the first reaction of a generic adenovirus-specific nested PCR (10).. New adenovirus in ... These results indicated that RV 1 must belong to the family Adenoviridae.. Isolation of novel adenovirus from fruit bat ( ...
more infohttps://www.freethesaurus.com/Adenoviridae
Publications | AIDS Clinical Trials Group  Publications | AIDS Clinical Trials Group
Adenoviridae. Li JZ, Brumme ZL, Brumme CJ, et al. "Factors associated with viral rebound in HIV-1-infected individuals enrolled ...
more infohttps://actgnetwork.org/pubmed_publications?f%5Btg%5D=F&s=keyword&o=asc
Retrovirus - Wikipedia  Retrovirus - Wikipedia
nonenveloped: Adenoviridae. *Papillomaviridae. *Papovaviridae (obsolete). *Polyomaviridae. *genera: Rhizidiovirus. * ...
more infohttps://en.wikipedia.org/wiki/SsRNA-RT_virus
Hepadnaviridae - Wikipedia  Hepadnaviridae - Wikipedia
nonenveloped: Adenoviridae. *Papillomaviridae. *Papovaviridae (obsolete). *Polyomaviridae. *genera: Rhizidiovirus. * ...
more infohttps://en.wikipedia.org/wiki/Hepadnaviridae
Virology by Christian - Issuu  Virology by Christian - Issuu
b. Adenoviruses belong to the family Adenoviridae and have been isolated from humans and animals. 2. Infections a. Respiratory ...
more infohttps://issuu.com/christianmugabo/docs/virology
Patent US20030152942 - Nucleic acid detection in pooled samples - Google Patents  Patent US20030152942 - Nucleic acid detection in pooled samples - Google Patents
In yet other preferred embodiments, the virus includes, but is not limited to, Parvoviridae, Papovaviridae, Adenoviridae, ...
more infohttp://www.google.com/patents/US20030152942?dq=6101531
The Rest of the DNA Viruses Flashcards by  | Brainscape  The Rest of the DNA Viruses Flashcards by | Brainscape
What can ADENOviridae cause? 1. Childhood upper respiratory tract infections (rhinitis, sore throat, fever, conjunctivitis).. 2 ...
more infohttps://www.brainscape.com/flashcards/the-rest-of-the-dna-viruses-2470204/packs/2562574
Alphabetical Browse | Britannica.com  Alphabetical Browse | Britannica.com
Family Adenoviridae. *chorea (animal disease). Chorea, in dogs, a disorder in which muscle spasms are prominent. It is usually ...
more infohttps://www.britannica.com/browse/alpha/c/123
Viruses  | Free Full-Text | Filovirus Research in Gabon and Equatorial Africa: The Experience of a Research Center in the Heart...  Viruses | Free Full-Text | Filovirus Research in Gabon and Equatorial Africa: The Experience of a Research Center in the Heart...
Adenoviridae. Adenovirus/UT. /Gabon. 2010-2012. Human. +/-. Reoviridae. Rotavirus/UT. /Gabon. 2010-2012. Human. +/-. ...
more infohttp://www.mdpi.com/1999-4915/4/9/1592/htm
Perspectives on immunotherapy via oncolytic viruses | SpringerLink  Perspectives on immunotherapy via oncolytic viruses | SpringerLink
Background With few exceptions, current chemotherapy and radiotherapy protocols only obtain a slightly prolonged survival with severe adverse effects in patients with advanced solid tumors. In...
more infohttps://link.springer.com/article/10.1186%2Fs13027-018-0218-1
  • Molecular analyses for several groups of viruses, including Herpesviridae, Paramyxoviridae, Adenoviridae , and all influenza A viruses, were performed on frozen lung samples from the badger and binturong and on frozen conjunctival and pharyngeal swabs from the ferret. (freethesaurus.com)
  • For instance, all members of the family Herpesviridae are enveloped viruses that contain an icosahedral particle and double-stranded DNA, whereas all members of the family Adenoviridae are nonenveloped viruses that contain an icosahedral particle and double-stranded DNA, with projecting fibers at the vertices of the protein shell. (freethesaurus.com)