Adenosine
Receptor, Adenosine A2A
Receptor, Adenosine A1
Adenosine Deaminase
Receptor, Adenosine A3
Receptor, Adenosine A2B
Adenosine Kinase
Receptors, Adenosine A2
Adenosine A2 Receptor Agonists
Adenosine A2 Receptor Antagonists
Receptors, Purinergic P1
Adenosine A1 Receptor Antagonists
Purinergic P1 Receptor Antagonists
Adenosine Monophosphate
Adenosine-5'-(N-ethylcarboxamide)
Theophylline
A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
Adenosine A3 Receptor Antagonists
Receptors, Purinergic
2-Chloroadenosine
Phenethylamines
Inosine
A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
5'-Nucleotidase
Cyclic AMP
Adenosine Triphosphatases
Tubercidin
Coformycin
Dipyridamole
Theobromine
3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
Pentostatin
Adenosine Phosphosulfate
Purines
Thioinosine
Triazines
Deoxyadenosines
Aminophylline
Dose-Response Relationship, Drug
Nucleoside Transport Proteins
Hypoxanthine
Nucleotidases
Hypoxanthines
Nucleosides
Apyrase
Adenylate Cyclase
Bucladesine
Cells, Cultured
Guinea Pigs
Ribonucleosides
Rats, Sprague-Dawley
Adenosylhomocysteinase
Receptors, Purinergic P2
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Myocardium
Rats, Wistar
Nucleotides
Dogs
8-Bromo Cyclic Adenosine Monophosphate
Colforsin
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Magnesium
Caffeine
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
Extracellular Space
Hyperemia
1-Methyl-3-isobutylxanthine
Vasodilation
Rabbits
Isoproterenol
S-Adenosylhomocysteine
Radioligand Assay
Dinucleoside Phosphates
Phosphodiesterase Inhibitors
RNA Editing
A process that changes the nucleotide sequence of mRNA from that of the DNA template encoding it. Some major classes of RNA editing are as follows: 1, the conversion of cytosine to uracil in mRNA; 2, the addition of variable number of guanines at pre-determined sites; and 3, the addition and deletion of uracils, templated by guide-RNAs (RNA, GUIDE).
Equilibrative Nucleoside Transporter 1
Adenosine Diphosphate Sugars
Purinergic P2 Receptor Antagonists
Guanosine
Enzyme Inhibitors
Rats, Inbred Strains
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Equilibrative-Nucleoside Transporter 2
Platelet Aggregation
Phosphotransferases
Enzyme Activation
Cell Membrane
Suramin
A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
3',5'-Cyclic-AMP Phosphodiesterases
Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP.
Formycins
Cyclic AMP-Dependent Protein Kinases
Stimulation, Chemical
The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
Purine-Nucleoside Phosphorylase
Potassium Channels
Cattle
Ischemic Preconditioning, Myocardial
Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.
Potassium
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Binding Sites
Hydrogen-Ion Concentration
Uridine Triphosphate
Affinity Labels
Dideoxyadenosine
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
Isopentenyladenosine
Depression, Chemical
The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
List of MeSH codes (D13)
... adenosine diphosphate MeSH D13.695.667.138.124.070 - adenosine diphosphate sugars MeSH D13.695.667.138.124.070.075 - adenosine ... n-ethylcarboxamide) MeSH D13.570.583.138.240 - s-adenosylhomocysteine MeSH D13.570.583.138.264 - s-adenosylmethionine MeSH ... adenosine diphosphate MeSH D13.695.827.068.124.070 - adenosine diphosphate sugars MeSH D13.695.827.068.124.070.075 - adenosine ... adenosine monophosphate MeSH D13.695.667.138.180.080 - adenosine phosphosulfate MeSH D13.695.667.138.236 - adenosine ...
Adenosine A2B receptor
N-ethylcarboxamide induces IL-6 expression via MAPKs and NF-kappaB activation through Akt, Ca(2+)/PKC, cAMP signaling pathways ... The adenosine A2B receptor, also known as ADORA2B, is a G-protein coupled adenosine receptor, and also denotes the human ... May 2022). "A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models ... alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting ...
Nil Casajuana Martin - Fingerprint
- Universitat Autònoma de Barcelona Research Portal
Adenosine 39% * 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine 33% ... N-ethylcarboxamide) 30% * G-Protein-Coupled Receptor Kinases 30% * 2-(4-(2-carboxyethyl)phenethylamino)-5'-N- ... 5 h-index Calculated based on number of publications stored in Pure and citations from Scopus ... 2-amino-4-(4-hydroxyphenyl)-6-(1H-imidazol-2-ylmethylsulfanyl)pyridine-3,5-dicarbonitrile 94% ...
pharmawuerz | Adenylate | BibSonomy
N-ethylcarboxamide)Adenosine/analogsAdenylateAdiposeAnimalsBloodBrainCellChemistry/drugCyclase/metabolismDiphosphate/ ... A2AA2BA3Activation/drugAdenosineAdenosine/*analogsAdenylateAnimalsAssayCHOCricetinaeCricetulusCyclase/metabolismEnzymeFusion ... A2AA2BA3AdenosineAdenosine/*analogsAdenylateAlkynes/*chemicalAnimalsCHOCricetinaeCyclase/metabolismHumansLigandsMagneticP1/* ... A3AMP/metabolismAdenosineAdenosine/analogsAdenylateAnimalsAssayBinding,CHOCompetitiveCompounds/chemistry/*pharmacology ...
Novel effects of adenosine receptors on pericellular hyaluronan matrix: implications for human smooth muscle cell phenotype and...
In conclusion, the current data suggest that adenosine via adenosine A2(B)R and A2(A)R/A3R induces HAS1. In turn a HA-rich ... Use of selective adenosine receptor antagonists revealed that adenosine A2(B) receptors (A2(B)R) mediate the early HAS1 ... Adenosine plays an important role in the phenotypic regulation of vascular smooth muscle cells (VSMC) and is thought to inhibit ... The aim of this study was to examine the regulation and function of HA matrix in response to adenosine in human coronary artery ...
Isopentenyladenosine | Profiles RNS
N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is a member of the cytokinin family of plant ...
Adenosine analogs and sleep in rats. | Journal of Pharmacology and Experimental Therapeutics
N-ethylcarboxamide and for 0.1 and 0.3 mumol/kg of N6-L-(phenylisopropyl)adenosine and 2) increased values for rapid-eye- ... The effects of N6-L-(phenylisopropyl)adenosine, cyclohexyladenosine and adenosine-5'-N-ethylcarboxamide on sleep were examined ... that activation of A1 rather than A2 receptors contributed to the sleep effects of the drugs because adenosine and adenosine ... Adenosine analogs and sleep in rats.. M Radulovacki, R M Virus, M Djuricic-Nedelson and R D Green ...
Lefteris Zacharia - Research output
- UNIC | Research Portal
A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction ... cAMP-adenosine pathway in the proximal tubule. Jackson, E. K., Zacharia, L. C., Zhang, M., Gillespie, D. G., Zhu, C. & Dubey, R ... The pancreatohepatorenal cAMP-adenosine mechanism. Jackson, E. K., Mi, Z., Zacharia, L. C., Tofovic, S. P. & Dubey, R. K., May ... Adenosine receptor expression and function in bladder uroepithelium. Yu, W., Zacharia, L. C., Jackson, E. K. & Apodaca, G., ...
CD markers antagonist | CD markers inhibitor | CD markers agonist | CD markers activator
... adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. ... adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. ... Cell Death Dis, 2022, 13(5):500 S6239. PMX-53 PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil ... Cell Death Dis, 2022, 13(5):500. S6239. PMX-53 PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil ...
pharmawuerz | Female | BibSonomy
CalciumA2B/agonists/*biosynthesisActivationAdenosineAdenosine-5'-(N-ethylcarboxamide)/pharmacologyAdenylateAssayBreastCell ... Acetylcholine/pharmacology/*physiologyAdenosine/pharmacologyAnimalsAtriaChannels/drugConductivityElectricFemaleHeartM2Male ... Cyclic4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/pharmacologyAMPAMP/metabolismAdenosine/analogsAdenylateAnimalsAtria/* ... 2Human breast cancer cell line MDA-MB-231 expresses endogenous A2B adenosine receptors mediating a Ca2+ signal. ...
Novel effects of adenosine receptors on pericellular hyaluronan matrix: implications for human smooth muscle cell phenotype and...
In conclusion, the current data suggest that adenosine via adenosine A2(B)R and A2(A)R/A3R induces HAS1. In turn a HA-rich ... Use of selective adenosine receptor antagonists revealed that adenosine A2(B) receptors (A2(B)R) mediate the early HAS1 ... Adenosine plays an important role in the phenotypic regulation of vascular smooth muscle cells (VSMC) and is thought to inhibit ... The aim of this study was to examine the regulation and function of HA matrix in response to adenosine in human coronary artery ...
Adenosine A2B receptor - Wikipedia
N-ethylcarboxamide induces IL-6 expression via MAPKs and NF-kappaB activation through Akt, Ca(2+)/PKC, cAMP signaling pathways ... The adenosine A2B receptor, also known as ADORA2B, is a G-protein coupled adenosine receptor, and also denotes the human ... May 2022). "A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models ... alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting ...
Adenosine analogs and sleep in rats. | Journal of Pharmacology and Experimental Therapeutics
N-ethylcarboxamide and for 0.1 and 0.3 mumol/kg of N6-L-(phenylisopropyl)adenosine and 2) increased values for rapid-eye- ... The effects of N6-L-(phenylisopropyl)adenosine, cyclohexyladenosine and adenosine-5-N-ethylcarboxamide on sleep were examined ... that activation of A1 rather than A2 receptors contributed to the sleep effects of the drugs because adenosine and adenosine ... Adenosine analogs and sleep in rats.. M Radulovacki, R M Virus, M Djuricic-Nedelson and R D Green ...
Lefteris Zacharia - Research output
- UNIC | Research Portal
A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction ... cAMP-adenosine pathway in the proximal tubule. Jackson, E. K., Zacharia, L. C., Zhang, M., Gillespie, D. G., Zhu, C. & Dubey, R ... The pancreatohepatorenal cAMP-adenosine mechanism. Jackson, E. K., Mi, Z., Zacharia, L. C., Tofovic, S. P. & Dubey, R. K., May ... Adenosine receptor expression and function in bladder uroepithelium. Yu, W., Zacharia, L. C., Jackson, E. K. & Apodaca, G., ...
Nil Casajuana Martin - Fingerprint
- Universitat Autònoma de Barcelona Research Portal
Adenosine 39% * 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine 33% ... N-ethylcarboxamide) 30% * G-Protein-Coupled Receptor Kinases 30% * 2-(4-(2-carboxyethyl)phenethylamino)-5-N- ... 5 h-index Calculated based on number of publications stored in Pure and citations from Scopus ... 2-amino-4-(4-hydroxyphenyl)-6-(1H-imidazol-2-ylmethylsulfanyl)pyridine-3,5-dicarbonitrile 94% ...
pharmawuerz | Female | BibSonomy
CalciumA2B/agonists/*biosynthesisActivationAdenosineAdenosine-5-(N-ethylcarboxamide)/pharmacologyAdenylateAssayBreastCell ... Acetylcholine/pharmacology/*physiologyAdenosine/pharmacologyAnimalsAtriaChannels/drugConductivityElectricFemaleHeartM2Male ... Cyclic4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/pharmacologyAMPAMP/metabolismAdenosine/analogsAdenylateAnimalsAtria/* ... 2Human breast cancer cell line MDA-MB-231 expresses endogenous A2B adenosine receptors mediating a Ca2+ signal. ...
pharmawuerz | Adenylate | BibSonomy
N-ethylcarboxamide)Adenosine/analogsAdenylateAdiposeAnimalsBloodBrainCellChemistry/drugCyclase/metabolismDiphosphate/ ... A2AA2BA3Activation/drugAdenosineAdenosine/*analogsAdenylateAnimalsAssayCHOCricetinaeCricetulusCyclase/metabolismEnzymeFusion ... A2AA2BA3AdenosineAdenosine/*analogsAdenylateAlkynes/*chemicalAnimalsCHOCricetinaeCyclase/metabolismHumansLigandsMagneticP1/* ... A3AMP/metabolismAdenosineAdenosine/analogsAdenylateAnimalsAssayBinding,CHOCompetitiveCompounds/chemistry/*pharmacology ...
Isopentenyladenosine | Profiles RNS
Search - NeL.edu
Journal Article 2011; 32(3): 274-278 PubMed PMID: 21712787 Citation Keywords: Adenosine-5-(N-ethylcarboxamide):pharmacology, ... Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes.. Kovárů H, Kovaru F ... METHODS: We studied the effect of acute administration of fluoxetine or NECA agonist of adenosine receptor (GPCR) on C6 glioma ... Kovárů H, Kovaru F, Ondráčkova P, Lisá V, Fiserová A. Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of ...
GLASS Ligand: NECA
N-ethylcarboxamide). CS-8131. MFCD00069195. NCGC00025260-03. [3H]adenosine-5-(N-ethylcarboxamide). 1-(6-Amino-9H-purin-9-yl)-1 ... Adenosine receptor A1. P47745. ADORA1. Cavia porcellus (Guinea pig). 326. 145773. Adenosine receptor A1. P28190. ADORA1. Bos ... Adenosine receptor A1. P30542. ADORA1. Homo sapiens (Human). 326. 145765. Adenosine receptor A1. P25099. Adora1. Rattus ... Adenosine receptor A1. P49892. ADORA1. Gallus gallus (Chicken). 324. 145764. Adenosine receptor A2a. P29274. ADORA2A. Homo ...
Evidence for co-expression and desensitization of A2a and A2b adenosine receptors in NG108-15 cells
The relatively non-selective adenosine receptor agonist 5-(N-ethyl car … ... the possible presence of both A2a and A2b adenosine receptor subtypes coupled to activation of adenylyl cyclase was ... N-ethylcarboxamide) / pharmacology * Adenylyl Cyclases / metabolism * Enzyme Activation * Glioma / enzymology ... Evidence for co-expression and desensitization of A2a and A2b adenosine receptors in NG108-15 cells Biochem Pharmacol. 1998 Mar ...
Role of adenosine receptors in caffeine tolerance
This study reassessed the role of adenosine receptors in caffeine tolerance. Separate … ... Caffeine is a competitive antagonist at adenosine receptors. Receptor up-regulation during chronic drug treatment has been ... N-ethylcarboxamide) * N(6)-cyclohexyladenosine * Caffeine * N-(4-hydroxyphenyl)-1-isopropyladenosine ... A2 adenosine receptor) and decreases (A1 adenosine receptor) in cAMP accumulation. These results are consistent with ...
MeSH Browser
N-ETHYLCARBOXAMIDE) was indexed under ADENOSINE/analogs & derivatives 1980-97. History Note. 98; use ADENOSINE-5-(N- ... Adenosine [D13.570.583.138] * Adenosine-5-(N-ethylcarboxamide) [D13.570.583.138.025] * S-Adenosylhomocysteine [D13.570.583.138 ... Adenosine [D13.570.800.096] * Adenosine-5-(N-ethylcarboxamide) [D13.570.800.096.250] * S-Adenosylhomocysteine [D13.570.800.096 ... Adenosine [D03.633.100.759.590.138] * Adenosine-5-(N-ethylcarboxamide) [D03.633.100.759.590.138.025] ...
MeSH Browser
N-ETHYLCARBOXAMIDE) was indexed under ADENOSINE/analogs & derivatives 1980-97. History Note. 98; use ADENOSINE-5-(N- ... Adenosine [D13.570.583.138] * Adenosine-5-(N-ethylcarboxamide) [D13.570.583.138.025] * S-Adenosylhomocysteine [D13.570.583.138 ... Adenosine [D13.570.800.096] * Adenosine-5-(N-ethylcarboxamide) [D13.570.800.096.250] * S-Adenosylhomocysteine [D13.570.800.096 ... Adenosine [D03.633.100.759.590.138] * Adenosine-5-(N-ethylcarboxamide) [D03.633.100.759.590.138.025] ...
NDF-RT Code NDF-RT Name
Adenosine A1 N0000168971 Receptor, Adenosine A2A N0000168972 Receptor, Adenosine A2B N0000168974 Receptor, Adenosine A3 ... N-ethylcarboxamide) N0000167696 Adenosylhomocysteinase N0000168055 Adenosylmethionine Decarboxylase N0000171135 Adenovirus E1 ... Coli Protein N0000007355 Adenosine N0000007816 Adenosine Deaminase N0000170811 Adenosine Diphosphate N0000170813 Adenosine ... Adenosine Diphosphate Ribose N0000170812 Adenosine Diphosphate Sugars N0000168241 Adenosine Kinase N0000170817 Adenosine ...
Interleukins antagonist | Interleukins inhibitor | Interleukins agonist | Interleukins activator
... adenosine, Adenosine-5N-ethylcarboxamide, 5-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. ... adenosine, Adenosine-5N-ethylcarboxamide, 5-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. ... GSK583 is a highly potent and selective inhibitor of RIP2 kinase with IC50 of 5 nM. GSK583 also inhibits both TNF-α and IL-6 ... GSK583 is a highly potent and selective inhibitor of RIP2 kinase with IC50 of 5 nM. GSK583 also inhibits both TNF-α and IL-6 ...
Publications - Labnodes - The Vanderbilt Research Network
MESH TREE NUMBER CHANGES - 2007 MeSH. September 14, 2006
D3.438.759.646.138 Adenosine D3.438.759.590.138 Adenosine Diphosphate D3.438.759.646.138.124 Adenosine Diphosphate Glucose ... N-ethylcarboxamide) D3.438.759.590.138.25 Adenylyl Imidodiphosphate D3.438.759.646.138.236.50 Adiposis Dolorosa C17.800.849.77 ... D3.438.759.646.138.180 Adenosine Phosphosulfate D3.438.759.646.138.180.80 Adenosine Triphosphate D3.438.759.646.138.236 ... D3.438.759.646.138.124.70.75 Adenosine Diphosphate Ribose D3.438.759.646.138.124.70.125 Adenosine Diphosphate Sugars D3.438. ...
Receptors2
- Use of selective adenosine receptor antagonists revealed that adenosine A2(B) receptors (A2(B)R) mediate the early HAS1 induction, whereas late HAS1 induction was mediated via A2(A)R and A3R. (nih.gov)
- It appears, therefore, that activation of A1 rather than A2 receptors contributed to the sleep effects of the drugs because adenosine and adenosine analogs activate A1 receptors in nanomolar quantities whereas activation of A2 receptors requires micromolar concentration of these compounds. (aspetjournals.org)
Receptor agonist1
- The adenosine receptor agonist NECA (10 μM) caused a strong induction of HA synthase (HAS)1 at 6 h and a weaker induction again after 24 h. (nih.gov)
Selective2
- Research into selective A2B ligands has lagged somewhat behind the development of ligands for the other three adenosine receptor subtypes, but a number of A2B-selective compounds have now been developed, and research into their potential therapeutic applications is ongoing. (wikipedia.org)
- BAY 60-6583 NECA (N-ethylcarboxamidoadenosine) (S)-PHPNECA - high affinity and efficacy at A2B, but poor selectivity over other adenosine receptor subtypes LUF-5835 LUF-5845 - partial agonist Compound 38: antagonist, high affinity and good subtype selectivity ISAM-R56A: non-xanthinic high affinity selective antagonist (Ki: 1.50 nM) ISAM-140: non-xanthinic selective antagonist (Ki: 3.49 nM). (wikipedia.org)
Protein2
- The adenosine A2B receptor, also known as ADORA2B, is a G-protein coupled adenosine receptor, and also denotes the human adenosine A2b receptor gene which encodes it. (wikipedia.org)
- This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. (wikipedia.org)
Human1
- The aim of this study was to examine the regulation and function of HA matrix in response to adenosine in human coronary artery SMC (HCASMC). (nih.gov)
Effects2
- The effects of N6-L-(phenylisopropyl)adenosine, cyclohexyladenosine and adenosine-5'-N-ethylcarboxamide on sleep were examined in rats. (aspetjournals.org)
- These effects consist of 1) increased slow-wave sleep2 from 6.6 to 45.7%, in all doses used for cyclohexyladenosine and adenosine-5'-N-ethylcarboxamide and for 0.1 and 0.3 mumol/kg of N6-L-(phenylisopropyl)adenosine and 2) increased values for rapid-eye-movement-sleep, amounting to 56.2 and 51.6% for 0.1 mumol/kg of cyclohexyl-adenosine and 0.3 mumol/kg of N6-L-(phenylisopropyl)adenosine, respectively. (aspetjournals.org)
NECA1
- Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes. (nel.edu)
Antagonists1
- Using receptor-selective agonists and antagonists, the possible presence of both A2a and A2b adenosine receptor subtypes coupled to activation of adenylyl cyclase was investigated in NG108-15 neuroblastoma x glioma hybrid cells. (nih.gov)
19981
- 1998 Mar 1;55(5):595-603. (nih.gov)
Caffeine5
- 5'-N-ethylcarboxamidoadenosine (0.001-1.0 mg/kg) dose dependently decreased the locomotor activity of caffeine-tolerant rats and their water-treated controls but was 8-fold more potent in the latter group. (nih.gov)
- Caffeine (1.0-10 mg/kg) injected concurrently with 5-N-ethylcarboxamidoadenosine antagonized the decreases in locomotor activity comparably in both groups. (nih.gov)
- Thus, the adenosine-antagonist activity of caffeine was undiminished in tolerant rats. (nih.gov)
- The effects of chronic caffeine administration on parameters of adenosine receptor binding and function were measured in cerebral cortex. (nih.gov)
- There were no differences between brain tissue from control and caffeine-treated rats in number and affinity of adenosine binding sites or in receptor-mediated increases (A2 adenosine receptor) and decreases (A1 adenosine receptor) in cAMP accumulation. (nih.gov)