Adenosine 5 n ethylcarboxamide. Medical search

A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

A subclass of adenosine A2 receptors found in LEUKOCYTES, the SPLEEN, the THYMUS and a variety of other tissues. It is generally considered to be a receptor for ADENOSINE that couples to the GS, STIMULATORY G-PROTEIN.

A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of tissues including the BRAIN and DORSAL HORN NEURONS. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.

An enzyme that catalyzes the hydrolysis of ADENOSINE to INOSINE with the elimination of AMMONIA.

A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of locations including the BRAIN and endocrine tissues. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.

A subclass of adenosine A2 receptors found in the CECUM, the COLON, the BLADDER, and a variety of other tissues. It is generally considered to be a low affinity receptor for ADENOSINE that couples to the GS, STIMULATORY G-PROTEIN.

An enzyme that catalyzes the formation of ADP plus AMP from adenosine plus ATP. It can serve as a salvage mechanism for returning adenosine to nucleic acids. EC 2.7.1.20.

A subclass of ADENOSINE RECEPTORS that are generally considered to be coupled to the GS, STIMULATORY G-PROTEIN which causes up regulation of CYCLIC AMP.

Compounds that selectively bind to and activate ADENOSINE A2 RECEPTORS.

Compounds that selectively bind to and block the activation of ADENOSINE A2 RECEPTORS.

A class of cell surface receptors that prefer ADENOSINE to other endogenous PURINES. Purinergic P1 receptors are widespread in the body including the cardiovascular, respiratory, immune, and nervous systems. There are at least two pharmacologically distinguishable types (A1 and A2, or Ri and Ra).

Compounds that bind to and block the stimulation of ADENOSINE A1 RECEPTORS.

Compounds that bind to and stimulate ADENOSINE A1 RECEPTORS.

Compounds that bind to and block the stimulation of PURINERGIC P1 RECEPTORS.

Purine bases found in body tissues and fluids and in some plants.

Compounds that bind to and stimulate PURINERGIC P1 RECEPTORS.

Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.

A stable adenosine A1 and A2 receptor agonist. Experimentally, it inhibits cAMP and cGMP phosphodiesterase activity.

A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.

Compounds that selectively bind to and block the activation of ADENOSINE A3 RECEPTORS.

Cell surface proteins that bind PURINES with high affinity and trigger intracellular changes which influence the behavior of cells. The best characterized classes of purinergic receptors in mammals are the P1 receptors, which prefer ADENOSINE, and the P2 receptors, which prefer ATP or ADP.

Drugs that selectively bind to and activate ADENOSINE A3 RECEPTORS.

2-Chloroadenosine. A metabolically stable analog of adenosine which acts as an adenosine receptor agonist. The compound has a potent effect on the peripheral and central nervous system.

A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)

N-Isopropyl-N-phenyl-adenosine. Antilipemic agent. Synonym: TH 162.

A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)

A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. It is cation-dependent and exists in a membrane-bound and soluble form. EC 3.1.3.5.

An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.

A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.

An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.

Catalyze the hydrolysis of nucleosides with the elimination of ammonia.

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)

3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

5'-Adenylic acid, monoanhydride with sulfuric acid. The initial compound formed by the action of ATP sulfurylase on sulfate ions after sulfate uptake. Synonyms: adenosine sulfatophosphate; APS.

A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.

Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503)

Heterocyclic rings containing three nitrogen atoms, commonly in 1,2,4 or 1,3,5 or 2,4,6 formats. Some are used as HERBICIDES.

A purine base and a fundamental unit of ADENINE NUCLEOTIDES.

Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.

Drugs that bind to and block the activation of PURINERGIC RECEPTORS.

The rate dynamics in chemical or physical systems.

A drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.

Drugs used to cause dilation of the blood vessels.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Proteins involved in the transport of NUCLEOSIDES across cellular membranes.

A purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.

A class of enzymes that catalyze the conversion of a nucleotide and water to a nucleoside and orthophosphate. EC 3.1.3.-.

Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.

Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)

A calcium-activated enzyme that catalyzes the hydrolysis of ATP to yield AMP and orthophosphate. It can also act on ADP and other nucleoside triphosphates and diphosphates. EC 3.6.1.5.

The circulation of blood through the CORONARY VESSELS of the HEART.

An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 4.6.1.1.

A cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed)

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.

Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

An enzyme which catalyzes the catabolism of S-ADENOSYLHOMOCYSTEINE to ADENOSINE and HOMOCYSTEINE. It may play a role in regulating the concentration of intracellular adenosylhomocysteine.

A class of cell surface receptors for PURINES that prefer ATP or ADP over ADENOSINE. P2 purinergic receptors are widespread in the periphery and in the central and peripheral nervous system.

A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.

A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.

The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)

The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

A long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.

Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.

A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.

A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.

Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM and the cell wall.

The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).

A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES

The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

Elements of limited time intervals, contributing to particular results or situations.

Treatment process involving the injection of fluid into an organ or tissue.

Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.

5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.

Purines with a RIBOSE attached that can be phosphorylated to PURINE NUCLEOTIDES.

Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).

A group of compounds which consist of a nucleotide molecule to which an additional nucleoside is attached through the phosphate molecule(s). The nucleotide can contain any number of phosphates.

Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.

A process that changes the nucleotide sequence of mRNA from that of the DNA template encoding it. Some major classes of RNA editing are as follows: 1, the conversion of cytosine to uracil in mRNA; 2, the addition of variable number of guanines at pre-determined sites; and 3, the addition and deletion of uracils, templated by guide-RNAs (RNA, GUIDE).

A subtype of equilibrative nucleoside transporter proteins that is sensitive to inhibition by 4-nitrobenzylthioinosine.

Inhibitor of phosphodiesterases.

Esters formed between the aldehydic carbon of sugars and the terminal phosphate of adenosine diphosphate.

Nucleotides in which the base moiety is substituted with one or more sulfur atoms.

Compounds that bind to and block the stimulation of PURINERGIC P2 RECEPTORS.

A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.

The hollow, muscular organ that maintains the circulation of the blood.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

A subtype of equilibrative nucleoside transporter proteins that is insensitive to inhibition by 4-nitrobenzylthioinosine.

The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.

A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.

Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.

An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.

The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.

Established cell cultures that have the potential to propagate indefinitely.

Relatively complete absence of oxygen in one or more tissues.

Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are widely distributed in animal tissue and control the level of intracellular cyclic AMP. Many specific enzymes classified under this heading demonstrate additional spcificity for 3',5'-cyclic IMP and CYCLIC GMP.

Pyrazolopyrimidine ribonucleosides isolated from Nocardia interforma. They are antineoplastic antibiotics with cytostatic properties.

A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.

The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.

An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free purine plus ribose-5-phosphate. EC 2.4.2.1.

The veins and arteries of the HEART.

An enzyme that catalyzes the deamination of AMP to IMP. EC 3.5.4.6.

Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

Compounds that bind to and stimulate PURINERGIC P2 RECEPTORS.

Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.

An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.

A pentose active in biological systems usually in its D-form.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Coronary vasodilator with some antiarrhythmic activity.

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.

Analogs of those substrates or compounds which bind naturally at the active sites of proteins, enzymes, antibodies, steroids, or physiological receptors. These analogs form a stable covalent bond at the binding site, thereby acting as inhibitors of the proteins or steroids.

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.

N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is a member of the cytokinin family of plant growth regulators.

The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.

... adenosine diphosphate MeSH D13.695.667.138.124.070 - adenosine diphosphate sugars MeSH D13.695.667.138.124.070.075 - adenosine ... n-ethylcarboxamide) MeSH D13.570.583.138.240 - s-adenosylhomocysteine MeSH D13.570.583.138.264 - s-adenosylmethionine MeSH ... adenosine diphosphate MeSH D13.695.827.068.124.070 - adenosine diphosphate sugars MeSH D13.695.827.068.124.070.075 - adenosine ... adenosine monophosphate MeSH D13.695.667.138.180.080 - adenosine phosphosulfate MeSH D13.695.667.138.236 - adenosine ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D13)

N-ethylcarboxamide induces IL-6 expression via MAPKs and NF-kappaB activation through Akt, Ca(2+)/PKC, cAMP signaling pathways ... The adenosine A2B receptor, also known as ADORA2B, is a G-protein coupled adenosine receptor, and also denotes the human ... May 2022). "A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models ... alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting ...

https://en.wikipedia.org/wiki/Adenosine_A2B_receptor

Adenosine 39% * 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine 33% ... N-ethylcarboxamide) 30% * G-Protein-Coupled Receptor Kinases 30% * 2-(4-(2-carboxyethyl)phenethylamino)-5'-N- ... 5 h-index Calculated based on number of publications stored in Pure and citations from Scopus ... 2-amino-4-(4-hydroxyphenyl)-6-(1H-imidazol-2-ylmethylsulfanyl)pyridine-3,5-dicarbonitrile 94% ...

https://portalrecerca.uab.cat/en/persons/nil-casajuana-martin-4/fingerprints/

N-ethylcarboxamide)Adenosine/analogsAdenylateAdiposeAnimalsBloodBrainCellChemistry/drugCyclase/metabolismDiphosphate/ ... A2AA2BA3Activation/drugAdenosineAdenosine/*analogsAdenylateAnimalsAssayCHOCricetinaeCricetulusCyclase/metabolismEnzymeFusion ... A2AA2BA3AdenosineAdenosine/*analogsAdenylateAlkynes/*chemicalAnimalsCHOCricetinaeCyclase/metabolismHumansLigandsMagneticP1/* ... A3AMP/metabolismAdenosineAdenosine/analogsAdenylateAnimalsAssayBinding,CHOCompetitiveCompounds/chemistry/*pharmacology ...

https://www.bibsonomy.org/user/pharmawuerz/Adenylate

In conclusion, the current data suggest that adenosine via adenosine A2(B)R and A2(A)R/A3R induces HAS1. In turn a HA-rich ... Use of selective adenosine receptor antagonists revealed that adenosine A2(B) receptors (A2(B)R) mediate the early HAS1 ... Adenosine plays an important role in the phenotypic regulation of vascular smooth muscle cells (VSMC) and is thought to inhibit ... The aim of this study was to examine the regulation and function of HA matrix in response to adenosine in human coronary artery ...

https://pubmed.ncbi.nlm.nih.gov/23440385/?dopt=Abstract

N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is a member of the cytokinin family of plant ...

https://profiles.jefferson.edu/display/12996

N-ethylcarboxamide and for 0.1 and 0.3 mumol/kg of N6-L-(phenylisopropyl)adenosine and 2) increased values for rapid-eye- ... The effects of N6-L-(phenylisopropyl)adenosine, cyclohexyladenosine and adenosine-5'-N-ethylcarboxamide on sleep were examined ... that activation of A1 rather than A2 receptors contributed to the sleep effects of the drugs because adenosine and adenosine ... Adenosine analogs and sleep in rats.. M Radulovacki, R M Virus, M Djuricic-Nedelson and R D Green ...

https://jpet.aspetjournals.org/content/228/2/268

A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction ... cAMP-adenosine pathway in the proximal tubule. Jackson, E. K., Zacharia, L. C., Zhang, M., Gillespie, D. G., Zhu, C. & Dubey, R ... The pancreatohepatorenal cAMP-adenosine mechanism. Jackson, E. K., Mi, Z., Zacharia, L. C., Tofovic, S. P. & Dubey, R. K., May ... Adenosine receptor expression and function in bladder uroepithelium. Yu, W., Zacharia, L. C., Jackson, E. K. & Apodaca, G., ...

https://pure.unic.ac.cy/en/persons/lefteris-zacharia/publications/?type=/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article&ordering=publicationYearThenTitle&descending=true

... adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. ... adenosine, Adenosine-5'N-ethylcarboxamide, 5'-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. ... Cell Death Dis, 2022, 13(5):500 S6239. PMX-53 PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil ... Cell Death Dis, 2022, 13(5):500. S6239. PMX-53 PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil ...

https://www.selleckchem.com/cd-markers.html

CalciumA2B/agonists/*biosynthesisActivationAdenosineAdenosine-5'-(N-ethylcarboxamide)/pharmacologyAdenylateAssayBreastCell ... Acetylcholine/pharmacology/*physiologyAdenosine/pharmacologyAnimalsAtriaChannels/drugConductivityElectricFemaleHeartM2Male ... Cyclic4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/pharmacologyAMPAMP/metabolismAdenosine/analogsAdenylateAnimalsAtria/* ... 2Human breast cancer cell line MDA-MB-231 expresses endogenous A2B adenosine receptors mediating a Ca2+ signal. ...

https://www.bibsonomy.org/user/pharmawuerz/Female

https://pubmed.ncbi.nlm.nih.gov/23440385/?dopt=Abstract

https://en.wikipedia.org/wiki/Adenosine_A2B_receptor

N-ethylcarboxamide and for 0.1 and 0.3 mumol/kg of N6-L-(phenylisopropyl)adenosine and 2) increased values for rapid-eye- ... The effects of N6-L-(phenylisopropyl)adenosine, cyclohexyladenosine and adenosine-5-N-ethylcarboxamide on sleep were examined ... that activation of A1 rather than A2 receptors contributed to the sleep effects of the drugs because adenosine and adenosine ... Adenosine analogs and sleep in rats.. M Radulovacki, R M Virus, M Djuricic-Nedelson and R D Green ...

https://jpet.aspetjournals.org/content/228/2/268

https://pure.unic.ac.cy/en/persons/lefteris-zacharia/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=publicationYearThenTitle&descending=true

Adenosine 39% * 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine 33% ... N-ethylcarboxamide) 30% * G-Protein-Coupled Receptor Kinases 30% * 2-(4-(2-carboxyethyl)phenethylamino)-5-N- ... 5 h-index Calculated based on number of publications stored in Pure and citations from Scopus ... 2-amino-4-(4-hydroxyphenyl)-6-(1H-imidazol-2-ylmethylsulfanyl)pyridine-3,5-dicarbonitrile 94% ...

https://portalrecerca.uab.cat/en/persons/nil-casajuana-martin-4/fingerprints/

CalciumA2B/agonists/*biosynthesisActivationAdenosineAdenosine-5-(N-ethylcarboxamide)/pharmacologyAdenylateAssayBreastCell ... Acetylcholine/pharmacology/*physiologyAdenosine/pharmacologyAnimalsAtriaChannels/drugConductivityElectricFemaleHeartM2Male ... Cyclic4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone/pharmacologyAMPAMP/metabolismAdenosine/analogsAdenylateAnimalsAtria/* ... 2Human breast cancer cell line MDA-MB-231 expresses endogenous A2B adenosine receptors mediating a Ca2+ signal. ...

https://www.bibsonomy.org/user/pharmawuerz/Female

https://www.bibsonomy.org/user/pharmawuerz/Adenylate

N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is a member of the cytokinin family of plant ...

https://profiles.jefferson.edu/display/12996

Journal Article 2011; 32(3): 274-278 PubMed PMID: 21712787 Citation Keywords: Adenosine-5-(N-ethylcarboxamide):pharmacology, ... Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes.. Kovárů H, Kovaru F ... METHODS: We studied the effect of acute administration of fluoxetine or NECA agonist of adenosine receptor (GPCR) on C6 glioma ... Kovárů H, Kovaru F, Ondráčkova P, Lisá V, Fiserová A. Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of ...

https://www.nel.edu/journal/search/?keywords=Neoplasms:metabolis

N-ethylcarboxamide). CS-8131. MFCD00069195. NCGC00025260-03. [3H]adenosine-5-(N-ethylcarboxamide). 1-(6-Amino-9H-purin-9-yl)-1 ... Adenosine receptor A1. P47745. ADORA1. Cavia porcellus (Guinea pig). 326. 145773. Adenosine receptor A1. P28190. ADORA1. Bos ... Adenosine receptor A1. P30542. ADORA1. Homo sapiens (Human). 326. 145765. Adenosine receptor A1. P25099. Adora1. Rattus ... Adenosine receptor A1. P49892. ADORA1. Gallus gallus (Chicken). 324. 145764. Adenosine receptor A2a. P29274. ADORA2A. Homo ...

https://seq2fun.dcmb.med.umich.edu/GLASS/ligand.cgi?id=JADDQZYHOWSFJD-FLNNQWSLSA-N

The relatively non-selective adenosine receptor agonist 5-(N-ethyl car … ... the possible presence of both A2a and A2b adenosine receptor subtypes coupled to activation of adenylyl cyclase was ... N-ethylcarboxamide) / pharmacology * Adenylyl Cyclases / metabolism * Enzyme Activation * Glioma / enzymology ... Evidence for co-expression and desensitization of A2a and A2b adenosine receptors in NG108-15 cells Biochem Pharmacol. 1998 Mar ...

https://pubmed.ncbi.nlm.nih.gov/9515570/

This study reassessed the role of adenosine receptors in caffeine tolerance. Separate … ... Caffeine is a competitive antagonist at adenosine receptors. Receptor up-regulation during chronic drug treatment has been ... N-ethylcarboxamide) * N(6)-cyclohexyladenosine * Caffeine * N-(4-hydroxyphenyl)-1-isopropyladenosine ... A2 adenosine receptor) and decreases (A1 adenosine receptor) in cAMP accumulation. These results are consistent with ...

https://pubmed.ncbi.nlm.nih.gov/1846425/

N-ETHYLCARBOXAMIDE) was indexed under ADENOSINE/analogs & derivatives 1980-97. History Note. 98; use ADENOSINE-5-(N- ... Adenosine [D13.570.583.138] * Adenosine-5-(N-ethylcarboxamide) [D13.570.583.138.025] * S-Adenosylhomocysteine [D13.570.583.138 ... Adenosine [D13.570.800.096] * Adenosine-5-(N-ethylcarboxamide) [D13.570.800.096.250] * S-Adenosylhomocysteine [D13.570.800.096 ... Adenosine [D03.633.100.759.590.138] * Adenosine-5-(N-ethylcarboxamide) [D03.633.100.759.590.138.025] ...

https://meshb-prev.nlm.nih.gov/record/ui?ui=D019830

https://meshb.nlm.nih.gov/record/ui?ui=D019830

Adenosine A1 N0000168971 Receptor, Adenosine A2A N0000168972 Receptor, Adenosine A2B N0000168974 Receptor, Adenosine A3 ... N-ethylcarboxamide) N0000167696 Adenosylhomocysteinase N0000168055 Adenosylmethionine Decarboxylase N0000171135 Adenovirus E1 ... Coli Protein N0000007355 Adenosine N0000007816 Adenosine Deaminase N0000170811 Adenosine Diphosphate N0000170813 Adenosine ... Adenosine Diphosphate Ribose N0000170812 Adenosine Diphosphate Sugars N0000168241 Adenosine Kinase N0000170817 Adenosine ...

https://evs.nci.nih.gov/ftp1/FDA/ndfrt/Archive/StructuralClass%202012-06-04.txt

... adenosine, Adenosine-5N-ethylcarboxamide, 5-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. ... adenosine, Adenosine-5N-ethylcarboxamide, 5-Ethylcarboxamidoadenosine) is a stable, nonselective adenosine receptor agonist. ... GSK583 is a highly potent and selective inhibitor of RIP2 kinase with IC50 of 5 nM. GSK583 also inhibits both TNF-α and IL-6 ... GSK583 is a highly potent and selective inhibitor of RIP2 kinase with IC50 of 5 nM. GSK583 also inhibits both TNF-α and IL-6 ...

https://www.selleck.eu/interleukins.html

MeSH Terms: Activins, Adenosine, Adenosine A2 Receptor Agonists, Adenosine-5-(N-ethylcarboxamide), Adult, Automation, Cell ... 2015) Sci Rep 5: 8334. MeSH Terms: Cell Movement, Fibroblasts, Fibronectins, Humans, Male, Neoplasm Proteins, Prostatic ...

https://labnodes.vanderbilt.edu/publication/search?filter%5Bsearch%5D%5Bquery%5D=Platelet-Derived%20Growth%20Factor&filter%5Bsearch%5D%5Bfields%5D%5B%5D=mesh_terms

D3.438.759.646.138 Adenosine D3.438.759.590.138 Adenosine Diphosphate D3.438.759.646.138.124 Adenosine Diphosphate Glucose ... N-ethylcarboxamide) D3.438.759.590.138.25 Adenylyl Imidodiphosphate D3.438.759.646.138.236.50 Adiposis Dolorosa C17.800.849.77 ... D3.438.759.646.138.180 Adenosine Phosphosulfate D3.438.759.646.138.180.80 Adenosine Triphosphate D3.438.759.646.138.236 ... D3.438.759.646.138.124.70.75 Adenosine Diphosphate Ribose D3.438.759.646.138.124.70.125 Adenosine Diphosphate Sugars D3.438. ...

https://nlmpubs.nlm.nih.gov/projects/mesh/.newterms/mnchg2007.txt

Receptors Receptor agonist Selective Protein Human Effects NECA Antagonists 1998 Caffeine

Use of selective adenosine receptor antagonists revealed that adenosine A2(B) receptors (A2(B)R) mediate the early HAS1 induction, whereas late HAS1 induction was mediated via A2(A)R and A3R. (nih.gov)
It appears, therefore, that activation of A1 rather than A2 receptors contributed to the sleep effects of the drugs because adenosine and adenosine analogs activate A1 receptors in nanomolar quantities whereas activation of A2 receptors requires micromolar concentration of these compounds. (aspetjournals.org)

The adenosine receptor agonist NECA (10 μM) caused a strong induction of HA synthase (HAS)1 at 6 h and a weaker induction again after 24 h. (nih.gov)

Research into selective A2B ligands has lagged somewhat behind the development of ligands for the other three adenosine receptor subtypes, but a number of A2B-selective compounds have now been developed, and research into their potential therapeutic applications is ongoing. (wikipedia.org)
BAY 60-6583 NECA (N-ethylcarboxamidoadenosine) (S)-PHPNECA - high affinity and efficacy at A2B, but poor selectivity over other adenosine receptor subtypes LUF-5835 LUF-5845 - partial agonist Compound 38: antagonist, high affinity and good subtype selectivity ISAM-R56A: non-xanthinic high affinity selective antagonist (Ki: 1.50 nM) ISAM-140: non-xanthinic selective antagonist (Ki: 3.49 nM). (wikipedia.org)

The adenosine A2B receptor, also known as ADORA2B, is a G-protein coupled adenosine receptor, and also denotes the human adenosine A2b receptor gene which encodes it. (wikipedia.org)
This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. (wikipedia.org)

The aim of this study was to examine the regulation and function of HA matrix in response to adenosine in human coronary artery SMC (HCASMC). (nih.gov)

The effects of N6-L-(phenylisopropyl)adenosine, cyclohexyladenosine and adenosine-5'-N-ethylcarboxamide on sleep were examined in rats. (aspetjournals.org)
These effects consist of 1) increased slow-wave sleep2 from 6.6 to 45.7%, in all doses used for cyclohexyladenosine and adenosine-5'-N-ethylcarboxamide and for 0.1 and 0.3 mumol/kg of N6-L-(phenylisopropyl)adenosine and 2) increased values for rapid-eye-movement-sleep, amounting to 56.2 and 51.6% for 0.1 mumol/kg of cyclohexyl-adenosine and 0.3 mumol/kg of N6-L-(phenylisopropyl)adenosine, respectively. (aspetjournals.org)

Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes. (nel.edu)

Using receptor-selective agonists and antagonists, the possible presence of both A2a and A2b adenosine receptor subtypes coupled to activation of adenylyl cyclase was investigated in NG108-15 neuroblastoma x glioma hybrid cells. (nih.gov)

1998 Mar 1;55(5):595-603. (nih.gov)

5'-N-ethylcarboxamidoadenosine (0.001-1.0 mg/kg) dose dependently decreased the locomotor activity of caffeine-tolerant rats and their water-treated controls but was 8-fold more potent in the latter group. (nih.gov)
Caffeine (1.0-10 mg/kg) injected concurrently with 5-N-ethylcarboxamidoadenosine antagonized the decreases in locomotor activity comparably in both groups. (nih.gov)
Thus, the adenosine-antagonist activity of caffeine was undiminished in tolerant rats. (nih.gov)
The effects of chronic caffeine administration on parameters of adenosine receptor binding and function were measured in cerebral cortex. (nih.gov)
There were no differences between brain tissue from control and caffeine-treated rats in number and affinity of adenosine binding sites or in receptor-mediated increases (A2 adenosine receptor) and decreases (A1 adenosine receptor) in cAMP accumulation. (nih.gov)

Anatomy7

Organisms8

Diseases2

Chemicals and Drugs95

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes13

Adenosine

Receptor, Adenosine A2A

Receptor, Adenosine A1

Adenosine Deaminase

Receptor, Adenosine A3

Receptor, Adenosine A2B

Adenosine Kinase

Receptors, Adenosine A2

Adenosine A2 Receptor Agonists

Adenosine A2 Receptor Antagonists

Receptors, Purinergic P1

Adenosine A1 Receptor Antagonists

Adenosine A1 Receptor Agonists

Purinergic P1 Receptor Antagonists

Xanthines

Purinergic P1 Receptor Agonists

Adenosine Monophosphate

Adenosine-5'-(N-ethylcarboxamide)

Theophylline

Adenosine A3 Receptor Antagonists

Receptors, Purinergic

Adenosine A3 Receptor Agonists

2-Chloroadenosine

Phenethylamines

Phenylisopropyladenosine

Inosine

5'-Nucleotidase

Cyclic AMP

Adenosine Triphosphatases

Tubercidin

Adenine Nucleotides

Nucleoside Deaminases

Coformycin

Dipyridamole

Theobromine

Pentostatin

Adenosine Phosphosulfate

Purines

Thioinosine

Triazines

Adenine

Deoxyadenosines

Purinergic Antagonists

Kinetics

Aminophylline

Vasodilator Agents

Dose-Response Relationship, Drug

Nucleoside Transport Proteins

Hypoxanthine

Nucleotidases

Hypoxanthines

Triazoles

Nucleosides

Apyrase

Coronary Circulation

Adenylate Cyclase

Bucladesine

Cells, Cultured

Guinea Pigs

Ribonucleosides

Rats, Sprague-Dawley

Adenosylhomocysteinase

Receptors, Purinergic P2

Calcium

Myocardium

Rats, Wistar

Nucleotides

Dogs

8-Bromo Cyclic Adenosine Monophosphate

Colforsin

Magnesium

Caffeine

Extracellular Space

Hyperemia

1-Methyl-3-isobutylxanthine

Vasodilation

Rabbits

Norbornanes

Time Factors

Perfusion