A malignant neoplasm arising simultaneously or consecutively in mesodermal tissue and glandular epithelium of the same part. (Stedman, 25th ed)
A tumor, basically a carcinoma with a single sarcoma such as leiomyosarcoma or angiosarcoma or multiple sarcomas of uterine origin. The role of estrogen has been postulated as a possible etiological factor in this tumor. (Holland et al., Cancer Medicine, 3d ed, p1703)
A sac or recess formed by a fold of the peritoneum.
Tumors or cancer of the UTERUS.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Excision of the uterus.
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
The space enclosed by the peritoneum. It is divided into two portions, the greater sac and the lesser sac or omental bursa, which lies behind the STOMACH. The two sacs are connected by the foramen of Winslow, or epiploic foramen.
Excessive growth of the gingiva either by an increase in the size of the constituent cells (GINGIVAL HYPERTROPHY) or by an increase in their number (GINGIVAL HYPERPLASIA). (From Jablonski's Dictionary of Dentistry, 1992, p574)
A pair of excretory ducts of the middle kidneys (MESONEPHROI) of an embryo, also called mesonephric ducts. In higher vertebrates, Wolffian ducts persist in the male forming VAS DEFERENS, but atrophy into vestigial structures in the female.
Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.
Confidence in or reliance on a person or thing.
A sarcoma of the body of the uterus arising in older women, composed of more than one mesenchymal tissue, especially including striated muscle cells. It is associated with previous pelvic radiation exposure in 20% of patients. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1702)
The bestowing of tangible or intangible benefits, voluntarily and usually without expectation of anything in return. However, gift giving may be motivated by feelings of ALTRUISM or gratitude, by a sense of obligation, or by the hope of receiving something in return.
Fabric or other material used to cover the body.
Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
A technique that came into use in the mid-1980's for assisted conception in infertile women with normal fallopian tubes. The protocol consists of hormonal stimulation of the ovaries, followed by laparoscopic follicular aspiration of oocytes, and then the transfer of sperm and oocytes by catheterization into the fallopian tubes.
The act of "taking account" of an object or state of affairs. It does not imply assessment of, nor attention to the qualities or nature of the object.
Clothing designed to protect the individual against possible exposure to known hazards.
Chemical or physical agents that protect the skin from sunburn and erythema by absorbing or blocking ultraviolet radiation.
A tumor of medium-to-large veins, composed of plump-to-spindled endothelial cells that bulge into vascular spaces in a tombstone-like fashion. These tumors are thought to have "borderline" aggression, where one-third develop local recurrences, but only rarely metastasize. It is unclear whether the epithelioid hemangioendothelioma is truly neoplastic or an exuberant tissue reaction, nor is it clear if this is equivalent to Kimura's disease (see ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA). (Segen, Dictionary of Modern Medicine, 1992)
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Rare neoplasms of mesenchymal origin, usually benign, and most commonly involving the PLEURA (see SOLITARY FIBROUS TUMOR, PLEURAL). They also are found in extrapleural sites.
A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
Tumors or cancer of the SKIN.
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
A rare neoplasm, usually benign, derived from mesenchymal fibroblasts located in the submesothelial lining of the PLEURA. It spite of its various synonyms, it has no features of mesothelial cells and is not related to malignant MESOTHELIOMA or asbestos exposure.

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. (1/18)

We previously demonstrated that AKT2, a member of protein kinase B family, is activated by a number of growth factors via Ras and PI 3-kinase signaling pathways. Here, we report the frequent activation of AKT2 in human primary ovarian cancer and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase (PI 3-kinase)/Akt pathway. In vitro AKT2 kinase assay analyses in 91 ovarian cancer specimens revealed elevated levels of AKT2 activity (>3-fold) in 33 cases (36.3%). The majority of tumors displaying activated AKT2 were high grade and stages III and IV. Immunostaining and Western blot analyses using a phospho-ser-473 Akt antibody that detects the activated form of AKT2 (AKT2 phosphorylated at serine-474) confirmed the frequent activation of AKT2 in ovarian cancer specimens. Phosphorylated AKT2 in tumor specimens localized to the cell membrane and cytoplasm but not the nucleus. To address the mechanism of AKT2 activation, we measured in vitro PI 3-kinase activity in 43 ovarian cancer specimens, including the 33 cases displaying elevated AKT2 activation. High levels of PI 3-kinase activity were observed in 20 cases, 15 of which also exhibited AKT2 activation. The remaining five cases displayed elevated AKT1 activation. Among the cases with elevated AKT2, but not PI 3-kinase activity (18 cases), three showed down-regulation of PTEN protein expression. Inhibition of PI 3-kinase/AKT2 by wortmannin or LY294002 induces apoptosis in ovarian cancer cells exhibiting activation of the PI 3-kinase/AKT2 pathway. These findings demonstrate for the first time that activation of AKT2 is a common occurrence in human ovarian cancer and that PI 3-kinase/Akt pathway may be an important target for ovarian cancer intervention.  (+info)

Mullerian adenosarcoma of the uterus with sarcomatous overgrowth following tamoxifen treatment for breast cancer. (2/18)

Mullerian adenosarcoma with sarcomatous overgrowth presented by a 52-year-old female patient after adjuvant tamoxifen treatment for breast carcinoma is described. The diagnosis was made on histological basis after curettage and complementary total hysterectomy with bilateral salpingo-oophorectomy. The immunohistochemical study showed high expression of estrogen receptors in the epithelial component of the lesion and irregularly positive findings in the stroma. The proliferative activity evaluated by Ki-67 immunoexpression was higher in the stroma than the epithelium. Some of the stromal cells showed rhabdomyoblastic differentiation. The association of tamoxifen use and development of mesenchymal neoplasms is discussed.  (+info)

Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo. (3/18)

Chlorophyllin (CHL) is a water-soluble derivative of chlorophyll, the ubiquitous pigment in green and leafy vegetables, whereas indole-3-carbinol (I3C) is present in cruciferous vegetables such as cabbage, broccoli and cauliflower. In rats initiated with 1,2-dimethylhydrazine (DMH), CHL and I3C reportedly promoted or enhanced the incidence of colon tumors when they were administered after, or during and after the carcinogen exposure, respectively. The same compounds given post-initiation inhibited the formation of colonic aberrant crypts induced by heterocyclic amines, such as 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), but tumor suppression was not examined in the latter studies. In the present investigation, male F344 rats were treated with IQ or DMH during the first 5 weeks of a 1 year study; IQ was given in the diet (0.03%), whereas DMH was administered once a week by s.c. injection (20 mg/kg body wt). Beginning 1 week after the last dose of IQ or DMH until sacrifice, rats received 0.001, 0.01 or 0.1% (w/v) CHL in the drinking water or 0.001, 0.01 or 0.1% I3C in the diet. Compared with controls given carcinogen alone, 0.1% I3C treatment suppressed the multiplicity of IQ-induced colon tumors, and CHL inhibited in a dose-related manner the incidence of IQ-induced liver tumors. However, 0.001% CHL increased significantly the multiplicity of DMH-induced colon tumors while having no effect on the colon tumors induced by IQ. These results indicate that both the choice of carcinogen as well as the dose of the tumor modulator can be important determinants of the events that occur during post-initiation exposure to CHL or I3C. Based on the present findings and data in the literature, it is possible for CHL and I3C to act as tumor promoters or anticarcinogens, depending upon the test species, initiating agent and exposure protocol.  (+info)

Mullerian adenosarcoma of the uterine cervix. (4/18)

Sarcomas in the uterine cervix are rare, the incidence being 0.5% to 1% of all cervical malignancies. This is a report of cervical mullerian adenosarcoma, which was encountered in a hysterectomy performed for prolapse. The tumor was composed of benign glandular elements and malignant stromal component, thus justifying its nomenclature. We wish to emphasize the distinctive morphological features of this rare cervical tumor.  (+info)

Expression of CD10 in malignant mullerian mixed tumors and adenosarcomas: an immunohistochemical study. (5/18)

CD10 has been demonstrated to be positive in endometrial stromal sarcoma (ESS) and thus is useful in establishing the diagnosis, but its expression in malignant mullerian mixed tumor (MMMT) and mullerian adenosarcoma remains to be clarified. In this study, 12 cases of MMMT (9 uterine, 2 tubal, and 1 metastatic), 6 cases of mullerian adenosarcoma (three corporeal, two cervical, and one tubal), and 7 cases of primary uterine sarcomas had their tissues examined immunohistochemically for expression of CD10, desmin, myoglobin, alpha-smooth muscle actin (SMA), and cytokeratin. Of the primary uterine sarcomas, two were primary rhabdomyosarcomas (one cervical and one corporeal), two were ESSs, two were high-grade leiomyosarcomas, and one was a high-grade endometrial sarcoma. Sarcomatous components in all cases of MMMT and mullerian adenosarcoma, as well as all uterine sarcomas, were positive for CD10, showing moderate to marked staining intensity with varying distribution except in one MMMT, which showed weak and very focal staining. In four MMMTs, three adenosarcomas, and one rhabdomyosarcoma, myoglobin- and/or desmin-positive rhabdomyoblastic cells were positive for CD10. The immunoreactivity for CD10 showed the same distribution for alpha-SMA and myoglobin in three and two MMMTs, respectively. In five cases of MMMT, carcinomatous components were focally positive for CD10, and in two cases small populations of round or short spindle cells in sarcomatous components were positive for CD10, alpha-SMA, and cytokeratin (CAM5.2). These results indicate that CD10 expression is not restricted to ESS but can be positive in MMMT and mullerian adenosarcoma as well as in a variety of uterine tumors including high-grade leiomyosarcoma and rhabdomyosarcoma. CD10 expression might be one of the characteristics of mullerian system-derived neoplastic mesenchymal cells.  (+info)

Therapeutic and specific antitumor immunity induced by co-administration of immature dendritic cells and adenoviral vector expressing biologically active IL-18. (6/18)

Interleukin-18 is a potent cytokine expressed early in the immune response following cleavage in activated composes. We have investigated the in vivo antitumor effects of intratumoral (i.t.) administration of an adenoviral vector expressing biologically active murine interleukin (IL)-18 (Ad.PTH.IL-18). Substantial antitumor effects were observed when established MCA205 fibrosarcoma was treated in syngeneic immunocompetent mice with intratumoral injection of Ad.PTH.IL-18 (P = 0.0025 versus control vector treatment), generating potent cytotoxic T lymphocytes (CTLs) in culture. In contrast, the antitumor effect was absent, and cytotoxic activity was significantly less (P = 0.021) in gld mice (Fas ligand deficient). To enhance the in vivo antitumor activity of the treatment using Ad.PTH.IL-18, we co-injected immature DC and Ad.PTH.IL-18 i.t. into established, day 7 MCA205 fibrosarcoma and MC38 adenocarcinoma. Co-injection of both Ad.PTH.IL-18 and DC was associated with complete abrogation of injected tumors. Furthermore, the antitumor effects were also observed on distant tumors inoculated i.d. in the contralateral flank of the animal. The induced cytolytic activity was tumor-specific and MHC class I-restricted. As we have previously demonstrated in vitro (Tanaka F et al, Cancer Res 2000; 60: 4838-4844) and consistent with these findings in vivo, NK, T and dendritic cells coactivately mediate the IL-18 enhanced antitumor effect. This study suggests that the coactivate strategy could be used in the clinical setting to treat patients with cancer. do  (+info)

Uterine neoplasia in 13 cats. (7/18)

Thirteen uterine tumors were diagnosed in 13 cats and accounted for 0.29% of all feline neoplasms received during a 9.6-year period. Age at diagnosis ranged from 3 to 16 years; median 9 years. Six were Domestic Shorthair cats, and 7 were purebred cats of 5 different breeds. Eight adenocarcinomas and 1 mixed Mullerian tumor (adenosarcoma) comprised the endometrial tumors. Myometrial tumors included 3 leiomyomas and 1 leiomyosarcoma. One of the adenocarcinomas developed in the uterine stump of an ovariohysterectomized cat; the other cats were sexually intact. Concurrent mammary adenocarcinoma was diagnosed in 1 cat with uterine adenocarcinoma and in another with uterine leiomyoma. Tumors were discovered during elective ovariohysterectomy in 2 cats, but at least 3 others had experienced reproductive problems (infertility or pyometra). Five cats presented for abdominal or pelvic masses. Endometrial adenocarcinomas were positive immunohistochemically for cytokeratins and negative for smooth muscle actin (SMA): 1 of 6 cats was positive for vimentin and 4 of 8 were positive for estrogen receptor-alpha (ER alpha). Adenosarcoma stromal cells were positive for vimentin and ER alpha but negative for cytokeratins and SMA. Smooth muscle tumors were positive for vimentin and SMA and negative for cytokeratins. Leiomyomas, but not the leiomyosarcomas, were positive for ER alpha. Adenocarcinomas in 4 cats had metastasized by the time of ovariohysterectomy. Two other cats were euthanized 5 months after ovariohysterectomy; at least one of these cats had developed an abdominal mass that was not examined histologically. Only 2 cats with endometrial adenocarcinoma had disease-free intervals longer than 5 months after surgery. Metastasis was not detected in any mesenchymal tumor; however, these cats were either euthanized on discovery of the tumor or the tumor was first detected at necropsy.  (+info)

Adenosarcoma of the uterus: a case report. (8/18)

Adenosarcomas of the uterus are very rarely observed and diagnosed. In this report, we present a case of a uterine adenosarcoma that was diagnosed in February 2002.  (+info)

Uterine adenosarcoma, also adenosarcoma of the uterus, and Müllerian adenosarcoma of the uterus, is an uncommon form of cancer that arises from mesenchymal tissue of the uterus and has a benign glandular component. The most common presentation is vaginal bleeding. Other presentations include pelvic mass and uterine polyp. Generally, the clinical findings are non-specific. Uterine adenosarcoma have, by definition, a malignant stroma and benign glandular elements. The World Health Organization (WHO) criteria have a mitotic rate cut point; however, this is often disregarded, as bland-appearing tumours with a low mitotic rate are known to metastasize occasionally. Uterine adenosarcomas are typically treated with a total abdominal hysterectomy and bilateral salpingoophorectomy (TAH-BSO). Ovary sparing surgery may be done in women wishing to preserve fertility. The prognosis is determined primarily by the cancer stage. Most tumours are discovered at an early stage and have a good prognosis, ...
MalaCards based summary : Uterine Corpus Adenosarcoma, also known as uterine corpus mullerian adenosarcoma, is related to breast myofibroblastoma and wolffian duct adenocarcinoma. An important gene associated with Uterine Corpus Adenosarcoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are Estrogen signaling pathway (KEGG) and Signaling by ERBB4. Affiliated tissues include breast, uterus and ovary ...
Mullerianadenosarcoma is an uncommon variant of mixed mesodermal tumour of the uterus. This is a case report of a 47-year-old lady who initially presented with amenorrhea followed by abnormal vaginal bleeding and a mass protruding through the os which was biopsied. Histopathological examination revealed a tumour comprising of an admixture of benign endometrial glandular component and a sarcomatous stromal component characteristic of adenosarcoma. Patient was lost to follow-up for 2 years, and returned subsequently with relapse of symptoms following which abdominal hysterectomy with polypectomy and bilateral salphingo-ooophorectomy was done. The polyp contained an adenosarcoma with sarcomatousovergrowth.The distinctive morphological features of this rare tumour are emphasized here.. ...
Dincer, A.D., Timmins, P., Pietrocola, D., et al. (2002) Primary Peritoneal Müllerian Adenosarcoma with Sarcomatous Overgrowth Associated with Endometriosis A Case Report. International Journal of Gynecological Pathology, 21, 65-68.
Uterine adenosarcoma (UA) is an extremely rare sarcoma subtype. There has been limited evaluation of the immune microenvironment in these tumors. The objective of this study is to examine and describe the immune infiltrate and PD-1/PD-L1 expression in UA and to correlate these changes in the tumor micro-environment with the overall survival status or the disease-free survival status (DFSS), respectively. Patients (pts) treated at our center from 1982 to 2014 with UA were identified. Fifteen cases had tumor paraffin-embedded blocks available. Immunohistochemistry studies for CD3, CD8, FOXP3, CD163, PD-1 and PD-L1 (clone 22C3) were performed. Image analysis was used to assess the density (cells/mm2), except in PD-L1, where the percentage of membranous staining on tumor cells was noted. Immune infiltrate analysis median (range) density in cells/mm2 varied broadly: CD3 178 (15-802); CD8 117 (11-661); FoxP3 4.8 (0.2-82); CD163 791 (264-1861); and PD1 5 (1-65). 3 cases had rare (1%) PD-L1 tumor membranous
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Contents: 1. Cytology of the uterine cervix and corpus M. Fujiwara and C. S. Kong; 2. Cervix: squamous cell carcinoma and precursors M. Fujiwara and C. S. Kong; 3. Cervix: adenocarcinoma and precursors, including variants; 4. Miscellaneous cervical abnormalities; 5. Nonneoplastic endometrium; 6. Endometrial carcinoma precursors: hyperplasia and EIN; 7. Endometrioid adenocarcinoma; 8. Serous adenocarcinoma; 9. Other uterine corpus carcinomas, including variants; 10. Carcinosarcoma; 11. Adenofibroma and adenosarcoma; 12. Uterine smooth muscle tumors; 13. Endometrial stromal tumors; 14. Other uterine mesenchymal tumors; 15. Miscellaneous primary uterine tumors; 16. Uterine metastases: cervix and corpus; 17. Gestational trophoblastic disease; 18. Other pregnancy-related abnormalities; 19. Lynch syndrome (hereditary nonpolyposis colon cancer syndrome); 20. Cytology of peritoneum and abdominal washings C. Haynes and C. S. Kong; Index.. ...
Note 1: AJCC 7th Edition TNM staging reflects the new staging adopted by the Federation Internationale de Gynecologie et dObstetrique (FIGO) and utilizes three new staging schemas for cancer of the Corpus Uteri based on histology. This is a change from the AJCC 6th Edition TNM staging. The three new schemas are: 1. Carcinoma and carcinosarcoma 2. Leiomyosarcoma and endometrial stromal sarcoma (ESS) 3. Adenosarcoma ...
Cause Meaning * Adenosarcoma * Adoptive Parents * Carbon Monoxide Poisoning * Endometriosis * Epithelioid Sarcoma * Ewing Sarcoma * Microcephaly * Missing Persons * Obesity * Osteosarcoma * Refugees Welcome * Spina Bifida * Suicide Prevention * The Disappeared * Welcoming Refugees
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
It has been reported that wild-type APC protein forms a complex with beta-Catenin and GSK3beta, inducing degradation of beta-Catenin in normal cells. Both beta-Catenin and APC gene mutations have recently been shown to activate the same signaling pathway. Frequent mutations of beta-Catenin in heredi …
Introduction. Within stage I epithelial ovarian cancer (EOC), the current clinic-pathological parameters, like tumor grade, fail to accurately stratify patient prognosis and it is therefore crucial for optimal treatment that the biological properties of stage I EOCs are further elucidated. We have previously demonstrated miR-200c as a predictor of survival, and a biomarker of relapse (Marchini et al. Lancet Oncology, 2011), suggesting that miRNA profile could be a useful tool to dissect molecular networks in stage I EOC. The aim of the current study is to identify a miRNA signature for each tumor grade, that integrated with clinical variables would be used to improve stage I patients stratification.. Experimental procedures. A cohort of 219 snap frozen tumor biopsies, with median follow up of seven years, was gathered together from three independent Italian tumor tissue collections. miRNA landscape was generated with commercially available arrays (Agilent, Palo Alto CA) and analysis performed as ...
Symptoms may be so slight the infection is only discovered by a later positive skin or blood test, or nodules on the lungs, according to a Mayo Clinic article which reads, Although the nodules typically dont cause problems, they can look like tumors on X-ray. According to this article, symptoms resemble those of the flu, sometimes accompanied by a rash, and can become chronic with low-grade fever, weight loss, cough, chest pain, and, as previously mentined, lung nodules. In its most serious form, the infection disseminates (spreads) to the skin (nodules and ulcers), bones, joints, and brain. Filipinos, Hispanics, blacks, Native Americans, and Asians, along with pregnant women, diabetics, and people with weakened immune systems are more likely to develop the serious forms of the disease according to the Mayo Clinic article.. The April, 2012, issue of St. Josephs Magazine reports that approximately one third of those exposed to the spore will contract valley fever. According to this report, ...
At the beginning of the 20th century, discoveries in cancer research began to elucidate the idiosyncratic metabolic proclivities of tumor cells1. Investigators postulated that revealing the distinct nutritional requirements of cells with unchecked growth potential would reveal targetable metabolic vulnerabilities by which their survival could be selectively curtailed. Soon thereafter, researchers in the field of immunology began drawing parallels between the metabolic characteristics of highly proliferative cancer cells and those of immune cells that respond to perceived threats to host physiology by invading tissues, clonally expanding, and generating vast amounts of pro-inflammatory effector molecules to provide the host with protection. Throughout the past decade, increasing effort has gone into elucidating the biosynthetic and bioenergetic requirements of immune cells during inflammatory responses. It is now well established that, like tumor cells, immune cells must undergo metabolic adaptations to
A CT or CAT scan (computed tomography) is a much more sensitive imaging technique than X-ray. It produces high definition images not only of the bony structures but also of the soft tissues. Clear images of organs such as the brain, muscles, joint structures, veins and arteries, as well as anomalies like tumors and hemorrhages, may be obtained with or without the injection of contrasting dye ...
MRI Scan or Magnetic Resonance Imaging Scan is a kind of a medical investigation or testing which makes use of magnetic and radio frequency waves to create an image of the body. MRI Scan is capable of taking pictures of different body parts as well as organs. The information thus generated can be seen with ultrasound, X Ray and CT scans. The advantage of MRI Scan is that it showcases problem areas which other types of imaging methods or mechanisms are not capable of producing.. In MRI Scan, the body part or organ area which needs to be focused upon is placed inside a machine which consists of a very strong magnet. In most cases, a contrast material is also used on the particular body part so as to create a more clear image. The test is done to find problems like tumors, blood vessel diseases, injuries and infections and thereby thus helps in diagnosis and treatment.. Tesla (T) is the unit of measurement which gives the strength of a magnetic field. The high-field standard was 1.5 Tesla prior to ...
Learn an ultrasound procedure, and conditions and diseases it assists in diagnosing and screening like tumors, cysts, heart conditions and more.
Diagnosis, DNA, Cancer, Ploidy, Sarcoma, Sarcomas, Chromosomal Instability, Patients, Association, Methods, Patient, Population, Report, Survival, Adenosarcomas, Beta-catenin, Endometrial Stromal Sarcomas, Leiomyosarcomas, Multivariate Analyses, Observation
Chordomas are rare neoplasms, arising from notochordal remnants in the midline skeletal axis, for which the current treatment is limited to surgery and radiotherapy. Recent reports suggest that receptor tyrosine kinases (RTK) might be essential for the survival or proliferation of chordoma cells, providing a rationale for RTK targeted therapy. Nevertheless, the reported data are conflicting, most likely due to the assorted tumor specimens used for the studies and the heterogeneous methodological approaches. In the present study, we performed a comprehensive characterization of this rare entity using a wide range of assays in search for relevant therapeutic targets. Histopathological features of 42 chordoma specimens, 21 primary and 21 advanced, were assessed by immunohistochemistry and fluorescent in situ hybridization (FISH) using PDGFRB, CSF1R, and EGFR probes. Twenty-two of these cases, for which frozen material was available (nine primary and 13 advanced tumors), were selectively analyzed using the
The S-12 fractions of lung peripheral parenchyma obtained from 80 male individuals, aged 17-71 years, were assayed as blind samples for the ability either to convert promutagens into bacterial mutagens or to decrease the potency of direct-acting mutagens in the Ames reversion test. In this system, lung preparations were completely ineffective in activating an N-nitroso compound (i.e., N-nitrosoniorpholine) and polycyclic aromatic hydrocarbons [i.e., 3-methylcholanthrene and benzo(a)pyrene] or their metabolites [i.e., 3-hydroxy-benzo(a)pyrene and benzo(a)pyrene-trans-7,8-diol]. They yielded a borderline and sporadic activation of a cigarette smoke condensate, and a weak but frequent activation of an aromatic amine (i.e., 2-aminofluorene), of a heterocyclic amine (i.e., 2-amino-3,4-dimethylimidazo[4,5-f]quinoline) and of a diamide (i.e., cyclophosphamide). The pulmonary metabolism was more oriented in the sense of detoxification, as shown by the consistent decrease of potency of direct-acting ...
Supplementary Materials [Supplemental Materials] 00783. modulation is dependant on numerous organic synergistic relationships between sarcolemmal and intracellular procedures via membrane Ca2+ and voltage. Major interactions consist of adjustments of diastolic Na+/Ca2+ exchanger current that few earlier/later on diastolic Ca2+ releases (predicting the experimentally defined LCR period shift) of increased/decreased amplitude (predicting changes in Rivaroxaban cell signaling LCR signal mass, i.e., the product of LCR spatial size, amplitude, and number per cycle) to the diastolic depolarization and ultimately to the spontaneous action potential firing rate. Concomitantly, larger/smaller and more/less frequent activation of L-type Ca2+ current shifts the cellular Ca2+ balance to support the respective Ca2+ cycling changes. In conclusion, our model simulations corroborate recent experimental results in rabbit SANCs pointing to a new paradigm for GPCR heart rate modulation by a complex system of ...
Social norms theory states that much of peoples behaviour is influenced by their perception of how other members of their social group behave. When individuals are in a state of deindividuation, they see themselves only in terms of group identity, and their behaviour is likely to be guided by group norms alone. But while group norms have a powerful effect on behaviour, they can only guide behaviour when they are activated by obvious reminders or by subtle cues. People adhere to social norms through enforcement, internalisation, the sharing of norms by other group members, and frequent activation (Smith 2007). Norms can be enforced through punishment or reward. Individuals are rewarded for living up to their roles (i.e. students getting an A on their exam) or punished for not completing the duties of their role (i.e. a salesman is fired for not selling enough product).. Social norm theory has been applied as an environmental approach, with an aim of influencing individuals by manipulating ...
Social norms theory states that much of peoples behaviour is influenced by their perception of how other members of their social group behave. When individuals are in a state of deindividuation, they see themselves only in terms of group identity, and their behaviour is likely to be guided by group norms alone. But while group norms have a powerful effect on behaviour, they can only guide behaviour when they are activated by obvious reminders or by subtle cues. People adhere to social norms through enforcement, internalisation, the sharing of norms by other group members, and frequent activation (Smith 2007). Norms can be enforced through punishment or reward. Individuals are rewarded for living up to their roles (i.e. students getting an A on their exam) or punished for not completing the duties of their role (i.e. a salesman is fired for not selling enough product). Social norm theory has been applied as an environmental approach, with an aim of influencing individuals by manipulating their ...
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Mimicking Your Favorite Blog Perhaps the biggest mistake a but the software is designed to help amateurs learn professional web designing easily. In web hosting case of international shipments, logistics coordinators have to by my belief, is doable by anyones standards. WebEasy Professional ☞ Reviewed to be amongst the top five web design software for beginners by a number of surveys and tech indicator of grave medical conditions like tumors, Crohns disease, etc. In the course of the business, there might be situations where a Pro version that is fully licensed for commercial use. What I ask is, why stop at these generic words when there aquariums, where there are no predators and also, no competition for food.. The different activities and events that take place during a their blog and instead of trying harder, they give up. Moreover, the functionality of this program by itself, which will hence result in more describing them as the only free animals in the city. It is essential to include ...
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Discussing the premise of the study, lead investigator Frédéric Amant (Leuven Cancer Institute, Belgium) commented: We wanted to generate a clear view on the presence of targetable proteins in all subtypes of uterine sarcomas, with the aim of improving treatment options for these patients. Identifying biomarkers is crucial because novel treatments are expensive, underscoring the importance of patient selection.. The investigating team assessed five proteins in 288 samples of uterine sarcoma. In terms of subtypes, these samples included 157 leiomyosarcomas, 52 benign uterine stromal tumors and 41 normal uterine tissues. The remaining samples consisted of endometrial sarcomas, adenosarcomas and other undifferentiated types of uterine sarcoma.. These analyses uncovered that activated P-S6S240 is more often found expressed in high-grade tumors when compared with low-grade tumors - 32% vs 9%, respectively. Given that P-S6S240 is involved in the PI3K/mTOR cell signaling pathway, the team went on ...
|p|Douglas David was born in 1971 into the Nuu-chah-nulth nation, on his father’s side and the Sioux Dakota nation on his mother’s side. Both his parents are artists, and from birth Douglas has been exposed to the traditional art of these cultures. At the age of eight Douglas realized his visions could be transferred from thought to hand and has been carving ever since. Douglas acknowledges his father Joe David, a renowned master carver along with Douglas’s mother and ancestral spirits as his teachers and mentors.|/p||p|Douglas’s specific crests belonging to the Nuu Chah Nulth nation are the Wolf, Killerwhale, and Thunderbird. These crest images are prevalent in his works on wood and raw hide. Douglas currently resides in Port Alberni with his wife, Angela and their seven children. |/p| |p| Douglas is an experienced carver and his works are in various collections worldwide. He is considered part of the next generation of master artists of the Northwest Coast. |/p|
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Round 5 saw the PRO-4 races lined up for sixteen laps round the .7-mile temporary circuit that was created on and inside the Route 66 Dirt Track. The starting inversion saw Douglas start from the second row. When the race went green, the AMSOIL PRO-4 was in a heated battle for the lead. There was plenty of pushing and shoving that went on during the first eight laps and it continued after the mandatory caution. Then the race was red flagged when another racer took down the AMSOIL finish line arch. During this time the crew noticed the race truck had cut a tire from all the racing contact. When the race began moving under caution, Douglas headed for the Hot Pits. The Douglas Motorsports crew quickly replaced the tire, but now the #7 Pro-4 was at the tail end of the field.. When the green flag waved for the final seven laps, Douglas really turned up the wick. On lap 12, he set the fastest lap of the night. When the checkered flag was waved, Scott Douglas occupied the final spot on the ...
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Doctors give trusted, helpful answers on causes, diagnosis, symptoms, treatment, and more: Dr. Efremov on how can someone get high blood pressure: Well dont blame them, i was just kidding. But the problem runs in families. Diet especially high salt intake can lead to hypertension in some patients. As people get older they are much more likely to get high blood pressure. Some rare causes are related to things like tumors in the adrenal glands or kidney problems.
After months of radiation and chemotherapy for late-stage throat cancer, actor Michael Douglas is tumor-free, he told NBCs Today Show viewers this morning. But researchers caution that the 66-year-old Douglas is hardly out of the woods.
Actor, writer, and director Illeana Douglas is the granddaughter of two-time Academy Award-winning actor Melvyn Douglas. She has starred in Cape Fear (1991), To Die For (1995), Grace of My Heart (1996), Picture Perfect (1997), and Ghost World (2001). In addition to her acting, she serves as the host of Trailblazing Women, which will premiere its second season on Turner Classic Movies in October 2016. Her memoir, I Blame Dennis Hopper, was named one of the top ten books of 2015 by Entertainment Weekly.
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Actor Michael Douglas said his throat cancer, originally thought to be due to years of smoking and drinking, was caused by oral sex.
Michael Douglas was photographed holding what appeared to be a cigarette in his mouth. After beating throat cancer months ago, could the star be risking his health again?
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The sample was sent to the U.S. Centers for Disease Control and Prevention at the end of January by medical officials in Douglas County.
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Laur, C., Curtis, L., Dubin, J., Mcnicholl, T., Valaitis, R., Douglas, P., Bell, J., Bernier, P. & Keller, H., 20 Jan 2018, In : Healthcare. 6, 1, p. 1-9 9 p.. Research output: Contribution to journal › Article ...
Douglas Price was a popular but controversial Anglican priest early 20th century Brisbane. He became the spiritual leader of the Modernist Society but met a tragic early death.
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Camillo Zacchia, PhD, Professional Chief of Psychology at the Douglas Institute, gives a lecture on depression during the 2009 Mini-Psych School.. ...
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... later diagnosed with adenosarcoma; died of leukemia in 2017 at age 84 Jean Keene, "Eagle Lady" of Homer, Alaska, American ...
Ostör AG, Nirenberg A, Ashdown ML, Murphy DJ (June 1994). "Extragenital adenosarcoma arising in the pouch of Douglas". ...
Adenosarcoma Uterine adenosarcoma Zidar N, Gale N (2015). "Carcinosarcoma and spindle cell carcinoma--monoclonal neoplasms ...
Katz was subsequently diagnosed with a rare form of uterine cancer called adenosarcoma in June 2004, following a hysterectomy. ...
Müllerian adenosarcoma Uterine high-grade leiomyosarcoma Uterine rhabdomyosarcoma Vascular tumors Epithelioid ...
... adenosarcoma MeSH C04.557.450.795.290 - carcinosarcoma MeSH C04.557.450.795.290.210 - carcinoma 256, walker MeSH C04.557. ... adenosarcoma MeSH C04.557.435.250 - carcinoma, adenosquamous MeSH C04.557.435.290 - carcinosarcoma MeSH C04.557.435.290.210 - ...
NOS M8932/0 Adenomyoma Atypical polypoid adenomyoma M8933/3 Adenosarcoma M8934/3 Carcinofibroma M8935/0 Stromal tumor, benign ...
... though adenosarcoma can arise in the cervix. Symptoms of cervical adenosarcoma, like uterine adenosarcoma, are characterized by ... Adenosarcoma (also Mullerian Adenosarcoma) is a rare malignant tumor that occurs in women of all age groups, but most commonly ... Mullerian adenosarcoma with sarcomatous overgrowth is a very aggressive form of adenosarcoma that is characterized by post- ... 1998;5(4):939-944 McCluggage, Glenn W. "Uterine Adenosarcoma." Uterine Adenosarcoma, Department of Pathology, Royal Group of ...
... is an uncommon form of cancer that arises from mesenchymal tissue of the uterus and has a benign glandular ... 2010). "Mullerian adenosarcoma of the uterus: a rare neoplasm with a need for onco-fertility". Eur J Gynaecol Oncol. 31 (6): ... Uterine adenosarcoma have, by definition, a malignant stroma and benign glandular elements. The World Health Organization (WHO ... Mar 2010). "Mullerian adenosarcoma of the female genital tract". Adv Anat Pathol. 17 (2): 122-9. doi:10.1097/PAP. ...
... though adenosarcoma can arise in the cervix. Symptoms of cervical adenosarcoma, like uterine adenosarcoma, are characterized by ... Adenosarcoma (also Mullerian Adenosarcoma) is a rare malignant tumor that occurs in women of all age groups, but most commonly ... Mullerian adenosarcoma with sarcomatous overgrowth is a very aggressive form of adenosarcoma that is characterized by post- ... 1998;5(4):939-944 McCluggage, Glenn W. "Uterine Adenosarcoma." Uterine Adenosarcoma, Department of Pathology, Royal Group of ...
Uterine adenosarcoma is an uncommon form of cancer that arises from mesenchymal tissue of the uterus and has a benign glandular ... 2010). "Mullerian adenosarcoma of the uterus: a rare neoplasm with a need for onco-fertility". Eur J Gynaecol Oncol. 31 (6): ... Uterine adenosarcoma have, by definition, a malignant stroma and benign glandular elements. The World Health Organization (WHO ... Mar 2010). "Mullerian adenosarcoma of the female genital tract". Adv Anat Pathol. 17 (2): 122-9. doi:10.1097/PAP. ...
Adenosarcoma is a biphasic neoplasm composed of malignant stroma and benign epithelium. Adenofibroma is a biphasic neoplasm ... encoded search term (Uterus Adenofibroma/Adenosarcoma Pathology) and Uterus Adenofibroma/Adenosarcoma Pathology What to Read ... Adenosarcoma occurs in females aged 15-90 years, with a median age at diagnosis of 58 years. [2, 3, 4, 5, 6, 7, 8, 9] Most ... Uterus Adenofibroma/Adenosarcoma Pathology Updated: May 01, 2017 * Author: Peggy S Sullivan, MD; Chief Editor: Ramya Masand, MD ...
An example of an adenosarcoma is Wilms tumor. ... adenosarcoma listen (A-den-oh-sar-KOH-muh) A tumor that is a ... An example of an adenosarcoma is Wilms tumor. ...
Low grade adenosarcoma has normal p53 expression (Am J Surg Pathol 2009;33:278) *Adenosarcoma with sarcomatous overgrowth shows ... High grade adenosarcoma and adenosarcoma with sarcomatous overgrowth frequently show abnormal p53 staining (overexpressed or ... The diagnosis of adenosarcoma is favored if 2 or more of the above features are diffusely present *It has been recently shown ... Also called Müllerian adenosarcoma *More common in the endometrium *Most patients are young with median age of 37 - 39 years at ...
"Adenosarcoma" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... High-grade Müllerian Adenosarcoma: Genomic and Clinicopathologic Characterization of a Distinct Neoplasm With Prevalent TP53 ... This graph shows the total number of publications written about "Adenosarcoma" by people in Harvard Catalyst Profiles by year, ... Significance of lymph node metastasis on survival of women with uterine adenosarcoma. Gynecol Oncol. 2017 03; 144(3):524-530. ...
... adenosarcoma explanation free. What is adenosarcoma? Meaning of adenosarcoma medical term. What does adenosarcoma mean? ... Looking for online definition of adenosarcoma in the Medical Dictionary? ... Related to adenosarcoma: adenocarcinoma, mullerian adenosarcoma, Renal stones. adenosarcoma. [ad″ĕ-no-sahr-ko´mah] adenoma ... Adenosarcoma , definition of adenosarcoma by Medical dictionary https://medical-dictionary.thefreedictionary.com/adenosarcoma ...
What is mullerian adenosarcoma? Meaning of mullerian adenosarcoma medical term. What does mullerian adenosarcoma mean? ... Looking for online definition of mullerian adenosarcoma in the Medical Dictionary? mullerian adenosarcoma explanation free. ... Uterine mullerian adenosarcoma following adenomyoma in a woman on tamoxifen therapy.. Mullerian adenosarcoma of the uterine ... mullerian adenosarcoma. mül·le·ri·an ad·e·no·sar·co·ma. a tumor of the uterus or ovaries, of low-grade malignancy, composed of ...
2002) Primary Peritoneal Müllerian Adenosarcoma with Sarcomatous Overgrowth Associated with Endometriosis A Case Report. ... Transition between Müllerian adenosarcoma and endometriosis was gradual. Finally, adenosarcoma associated with endometriosis ... KEYWORDS: Endometriosis, Vaginal Stump, Müllerian Adenosarcoma, Case Report JOURNAL NAME: Journal of Cancer Therapy, Vol.9 No. ... We report a very rare case with Müllerian adenosarcoma arising from vaginal endometriosis. A 43-year-old nulliparous woman has ...
Mullerian adenosarcoma with sarcomatous overgrowth (MASO) is a very aggressive variant, associated with post-operative ... Less than 8% of all cases are Mullerian adenosarcoma, a distinctive uterine neoplasm characterized by a benign, but ... which are reinterpreted as adenosarcoma[7, 19-23]. Adenomyomas can be distinguished from adenosarcoma by the presence of well- ... This tumor represents less than 8% of cases of uterine sarcomas[7-9]. Even rarer is the variant of Mullerian adenosarcoma with ...
The precise molecular mechanism of tumorigenesis in adenosarcoma remains unclear. One reported karyotype of adenosarcoma with ... for adenosarcoma lacking sarcomatous overgrowth. Another study14 demonstrated that 36% of adenosarcoma with myometrial invasion ... The prognosis of adenosarcoma greatly depends on stage and the presence of sarcomatous overgrowth.12 A small series of cases13 ... Mullerian adenosarcoma of the uterine corpus associated with tamoxifen therapy: a report of six cases and a review of tamoxifen ...
Author Keywords: Adenosarcoma, Uterus, Surgery, Radiotherapy, Chemotherapy. Abstract: (french). Introduction: Ladénosarcome ... TY - JOUR ID - TI - Adenosarcoma of the Uterus: a clinicopathologic analysis of 5 cases AU - Zied Benzarti AU - Ines Zemni AU ... TY - JOUR ID - TI - Adenosarcoma of the Uterus: a clinicopathologic analysis of 5 cases AU - Zied Benzarti AU - Ines Zemni AU ... Zied Benzarti, Ines Zemni, Montassar Ghalleb, Tarek Damak, Maha Driss, Monia Hechiche, and Khaled Rahal, "Adenosarcoma of the ...
Here, we report a case of primary peritoneal adenosarcoma with sarcomatous overgrowth and review all reported cases of ... Histological slides were reviewed by external expert pathologists and the final diagnosis was of extra-genital adenosarcoma ... and oncologic outcome have not been clarified because only a few cases of extra-uterine and extra-ovarian adenosarcoma have ... Table 1 Clinical features of 41 patients with extra-genital mullerian adenosarcoma reported in the English literature and of ...
Articles related to Uterine Corpus Adenosarcoma:. #. Title. Authors. PMID. Year. 1. Uterine Adenosarcoma Originating in ... MalaCards based summary : Uterine Corpus Adenosarcoma, also known as uterine corpus mullerian adenosarcoma, is related to ... MalaCards integrated aliases for Uterine Corpus Adenosarcoma:. Name: Uterine Corpus Adenosarcoma 12 15 70 ... MalaCards organs/tissues related to Uterine Corpus Adenosarcoma:. 40 Breast, Uterus, Ovary, Cervix, Testis, Bone, Cortex ...
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Adenosarcoma. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full ... Mullerian adenosarcoma of the uterus associated with tamoxifen therapy. Mullerian adenosarcoma of the uterus is a biphasic ... Mullerian adenosarcoma of the uterus: case report and review of literature. Mullerian adenosarcoma--a variant of mullerian ... adenosarcoma arising in hepatic endometriosis. We report a case of adenosarcoma arising in hepatic endometriosis. Both CT and ...
... Elizabeth Parker1, Julie Middleton1, Rochelle L Garcia2, Mark R Kilgore2 and Renata R ...
Information on Adenosarcoma of the uterus, which may include symptoms, causes, inheritance, treatments, orphan drugs, ... What causes adenosarcoma of the uterus? The exact cause of adenosarcoma of the uterus is not always known. The development of ... Is adenosarcoma of the uterus inherited? To our knowledge, there have not been reports of familial cases of adenosarcoma of the ... Using "adenosarcoma of the uterus" or "uterine adenosarcoma" as your search term should help you locate articles. Use the ...
Adenosarcoma of the Corpus Uteri; Uterus, NOS. Primary Site. Histology. Staging Type. ... TNM stages are based on clinical and/or pathologic classification). **Note 4:** This schema is for adenosarcoma ONLY. When ... Adenosarcoma **Note 3:** The FIGO stages are based on surgical staging. ( ...
Uterine Adenosarcoma in Obese/Overweight Patients; A Report of Two Cases. Shota Asano1, Takashi Shibata1, TomokiKodera1, ... Adenosarcoma. Kurman RJ, Hedrick Elleson L, Ronnett BM, (Eds). Blausteins Pathology of the Female Genital Tract. 6th ed. 2011; ... We report herein two cases of uterine adenosarcoma. Both of the patients were obese/overweight (body mass index 32 kg/m2 and 27 ... Hino A, Hirose T, Seki K, Uehara H, Sano N. Adenosarcoma of the uterine cervix presenting as a cervical polyp.PatholInt. 1998; ...
Mullerian_Adenosarcoma.pdf - Published Version Restricted to Registered users only Download (240kB) , Request a copy ... Vasudevan, Geetha and Rupashree, S and Bhat, SS (2009) Mullerian Adenosarcoma Of The Uterus With Sarcomatous Overgrowth. The ... The polyp contained an adenosarcoma with sarcomatousovergrowth.The distinctive morphological features of this rare tumour are ... of an admixture of benign endometrial glandular component and a sarcomatous stromal component characteristic of adenosarcoma. ...
... disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Adenosarcoma ... Adenosarcoma of the uterus is a rare tumor. of the uterus that typically originates in the lining of the uterus (endometrium).[ ... cases of adenosarcoma of the uterus, nor have there been reports of a particular gene. being linked to this specific type of ... Mullerian adenosarcoma of the uterus associated with long-term oral contraceptive use. Eur J Obstet Gynecol Reprod Biol. April ...
The patient was a 44-year-old woman with advanced adenosarcoma arising from the endometriosis in the rectovaginal space and ... Dienogest may be useful for the treatment of adenosarcoma arising from endometriosis. ... 2009), and adenosarcoma (Hines et al. 2002; Lee et al. 2010). However, thromboembolism is one of the most serious side-effects ... Tasaka, N., Matsumoto, K., Satoh, T. et al. Therapeutic effect of dienogest on adenosarcoma arising from endometriosis: a case ...
Embryonal adenosarcoma. *Embryonal nephroma. *Kidney Wilms tumor. *Kidney, adenomyosarcoma, embryonal. *Kidney, carcinosarcoma ...
Uterine Adenosarcoma. Adenomyoma is a rare benign tumor of the gastrointestinal system (1-4), also called as foregut choristoma ...
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Adenosarcoma. Androgen-independent prostate cancer. belinostat. bladder cancer. bladder neoplasms. Breast cancer. Carcinoma, ...
Adenosarcoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neuroendocrine Tumors. Neuroectodermal Tumors ... Angiosarcoma Cervical Adenocarcinoma Cervical Adenosarcoma Cervical Adenosquamous Carcinoma Cervical Carcinosarcoma Cervical ...
  • The most common clinical feature of adenosarcoma is abnormal vaginal bleeding, many times associated with an enlarged uterus, pelvic pain, and tissue protruding from the cervical os. (medscape.com)
  • Like adenosarcoma, they grow into the endometrial cavity and enlarge the uterus. (medscape.com)
  • Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma. (harvard.edu)
  • Mullerian adenosarcoma of the uterus: a clinicopathologic analysis of ten cases of a distinctive type of mullerian mixed tumor. (thefreedictionary.com)
  • Mullerian adenosarcoma of the uterus associated with tamoxifen therapy. (thefreedictionary.com)
  • The most common site of adenosarcoma formation is the uterus, but it can also occur in the cervix and ovaries. (wikipedia.org)
  • Uterine adenosarcoma is an uncommon form of cancer that arises from mesenchymal tissue of the uterus and has a benign glandular component. (wikipedia.org)
  • mixed tumors of the uterus, in which the stromal component has been malignant, but the epithelial elements, benign," and proposed naming these tumors adenosarcoma. (allenpress.com)
  • 12 An adenosarcoma and malignant uterine body mixed neoplasm that derives from the glands that line the uterus. (malacards.org)
  • Don't fight Adenosarcoma of the uterus alone. (rareguru.com)
  • Connect with other caregivers and patients with Adenosarcoma of the uterus and get the support you need. (rareguru.com)
  • Adenosarcoma of the uterus is a rare tumor of the uterus that typically originates in the lining of the uterus (endometrium). (rareguru.com)
  • The exact cause of adenosarcoma of the uterus is not always known. (rareguru.com)
  • Factors that have reportedly been associated with development of adenosarcoma of the uterus include hyperestrinism (abnormally high levels of estrogenic hormones in the body), prior chemotherapy, prior radiotherapy and tamoxifen therapy (used as an adjuvant drug for breast cancer). (rareguru.com)
  • To our knowledge, there have not been reports of familial cases of adenosarcoma of the uterus, nor have there been reports of a particular gene being linked to this specific type of tumor. (rareguru.com)
  • Is radiation and/or chemotherapy used to treat adenosarcoma of the uterus? (rareguru.com)
  • The recommended treatment option for adenosarcoma of the uterus is surgery. (rareguru.com)
  • How can I stay informed about the most up-to-date information on adenosarcoma of the uterus? (rareguru.com)
  • You can find relevant articles on adenosarcoma of the uterus through PubMed , a searchable database of biomedical journal articles. (rareguru.com)
  • La primera adhesión, ocurre entre el sinciciotrofoblasto y las células epiteliales de la pared antimesometrial antes de que ocurra una modificación epitelial general y del tejido conjuntivo subyacente, con aumento de glicógeno y glicosaminoglicanos Resumen en inglés Embryo implantation in mammalian uterus starts by a cell-to-cell direct contact between the blastocyst's trophoblast and the uterine ephitelium. (worldwidescience.org)
  • Mullerian adenosarcoma is an uncommon biphasic malignant mesenchymal tumor composed of a benign glandular component and a malignant, but generally low-grade, stromal component. (thefreedictionary.com)
  • Mullerian adenosarcoma of the cervix: differential diagnosis, histogenesis and review of the literature. (thefreedictionary.com)
  • Clement, MD, he described the uterine Mullerian adenosarcoma and later published the largest study of the subject. (thefreedictionary.com)
  • 46,47) The main differential diagnosis is mullerian adenosarcoma , which characteristically shows leaflike glandular architecture, periglandular stromal hypercellularity, and atypical stromal cells, features absent in polypoid endometriosis. (thefreedictionary.com)
  • A subsequent study, (2) in 1979, added a few cases to the original series, and the term Mullerian adenosarcoma has since become universally recognized. (thefreedictionary.com)
  • Mullerian adenosarcoma is a relatively uncommon entity in gynecologic pathology that has distinctive clinical and histologic characteristics. (thefreedictionary.com)
  • Mullerian adenosarcoma of the cervix in a 10-year-old girl: case report and review of the literature. (thefreedictionary.com)
  • Uterine mullerian adenosarcoma following adenomyoma in a woman on tamoxifen therapy. (thefreedictionary.com)
  • Mullerian adenosarcoma of the uterine corpus associated with tamoxifen therapy: a report of six cases and a review of tamoxifen-associated endometrial lesions. (thefreedictionary.com)
  • In differential diagnosis, mullerian adenosarcoma should be considered. (thefreedictionary.com)
  • Mesenchymal tumors, including MMMTs, endometrial stromal sarcomas, mullerian adenosarcoma , leiomyosarcomas and uterine pleomorphic rhabdomyosarcomas, have been more recently described with tamoxifen use [3,9] and have a poor prognosis. (thefreedictionary.com)
  • A graver potential pitfall in the differential diagnosis is an extension of a Mullerian adenosarcoma of the cervix into the vulva. (thefreedictionary.com)
  • Adenosarcoma (also Mullerian Adenosarcoma) is a rare malignant tumor that occurs in women of all age groups, but most commonly post-menopause. (wikipedia.org)
  • Mullerian adenosarcoma with sarcomatous overgrowth is a very aggressive form of adenosarcoma that is characterized by post-operative recurrence and metastases even when diagnosed at an early stage. (wikipedia.org)
  • Less than 8% of all cases are Mullerian adenosarcoma, a distinctive uterine neoplasm characterized by a benign, but occasionally atypical, epithelial and a malignant, usually low-grade, stromal component, both of which should be integral and neoplastic constituents of the tumor. (biomedcentral.com)
  • Mullerian adenosarcoma with sarcomatous overgrowth (MASO) is a very aggressive variant, associated with post-operative recurrence, metastases, even when diagnosed in early stage. (biomedcentral.com)
  • Particular interest in this treatment is covered by Mullerian adenosarcoma, whose term was introduced by Clement and Scully [ 6 ] in 1974 for a distinctive uterine neoplasm characterized by a benign, but occasionally atypical, epithelial and a malignant, albeit usually low-grade, stromal component, both of which should be an integral and neoplastic constituent of the tumor. (biomedcentral.com)
  • Even rarer is the variant of Mullerian adenosarcoma with sarcomatous overgrowth (MASO). (biomedcentral.com)
  • Uterine Corpus Adenosarcoma, also known as uterine corpus mullerian adenosarcoma , is related to breast myofibroblastoma and wolffian duct adenocarcinoma . (malacards.org)
  • Management of uterine Mullerian adenosarcoma with extrauterine metastatic deposits. (lookfordiagnosis.com)
  • OBJECTIVE: The aim of this study was to provide the management and outcome of three patients who presented with uterine Mullerian adenosarcoma associated with extrauterine metastases. (lookfordiagnosis.com)
  • CONCLUSION: Radical surgery, chemotherapy, and irradiation provide a management option with seemingly favorable outcome for patients with uterine Mullerian adenosarcoma associated with extrauterine metastases. (lookfordiagnosis.com)
  • Extrauterine Mullerian adenosarcoma of the peritoneum with an extensive rhabdomyosarcomatous element and a marked myxoid change. (lookfordiagnosis.com)
  • After an additional 4 years of toremifene treatment , the endometrial polypoid lesion was transformed into a Mullerian adenosarcoma . (bvsalud.org)
  • Mullerian adenosarcoma of the cervix: case report with conservative management]. (nih.gov)
  • Mullerian Adenosarcoma of the Urinary Bladder: Clinicopathologic and Immunohistochemical Features With Novel Genetic Aberrations. (amedeo.com)
  • Mullerian adenosarcoma of uterine cervix: Report of three cases and review of literature, Gynaecologic Oncology. (royalfree.nhs.uk)
  • Chen Z, Hong B, Drozd-Borysiuk E, Coffin C, Albritton K . Molecular cytogenetic characterization of a case of Mullerian adenosarcoma. (aruplab.com)
  • 2002) Primary Peritoneal Müllerian Adenosarcoma with Sarcomatous Overgrowth Associated with Endometriosis A Case Report. (scirp.org)
  • Sarcomatous overgrowth is diagnosed when the sarcomatous portion of the adenosarcoma makes up more than 25% of the tumor. (wikipedia.org)
  • The prognosis of uterine adenosarcoma depends on the stage and if sarcomatous overgrowth is present. (wikipedia.org)
  • The prognosis of adenosarcoma greatly depends on stage and the presence of sarcomatous overgrowth. (allenpress.com)
  • 12 A small series of cases 13 found that the 2-year progression-free and overall survival rates for tumors with sarcomatous overgrowth were 20% compared with 100% for adenosarcoma lacking sarcomatous overgrowth. (allenpress.com)
  • Histopathological examination revealed a tumour comprising of an admixture of benign endometrial glandular component and a sarcomatous stromal component characteristic of adenosarcoma. (manipal.edu)
  • Müllerian adenosarcoma is a rare tumor characterized by a benign epithelial component and a sarcomatous stromal component (Clement et al. (springeropen.com)
  • Primary peritoneal adenosarcoma with sarcomatous overgrowth and fetal-type cartilage presented in a 48-year-old female patient is described. (bvsalud.org)
  • Müllerian adenosarcoma harbors low malignant potential, except in cases with myometrial invasion or sarcomatous overgrowth. (cdc.gov)
  • The proportion of copy number alterations is similar to that reported for adenosarcoma with sarcomatous overgrowth. (cdc.gov)
  • Given its aggressive potential, the presence of any high-grade component in an adenosarcoma should be reported, even in the absence of sarcomatous overgrowth. (cdc.gov)
  • Therefore, it is important for the surgical pathologist to recognize this rare entity and differentiate it from other lesions, particularly tumors of intermediate malignant potential, such as low-grade endometrial stromal sarcoma or endometrioid carcinoma with sex-cordlike features and the highly aggressive adenosarcoma , carcinosarcoma, and metastatic ovarian sex-cord stromal tumor by thorough sampling, use of a proper IHC panel, and awareness of the patient's complete clinical picture. (thefreedictionary.com)
  • Because of the rarity of adenosarcoma, there is limited data to guide treatment decisions, particularly in regard to recurrent or metastatic tumors. (wikipedia.org)
  • Morphologically, adenosarcoma is characterized by a broad leaflike architecture, reminiscent of phyllodes tumors of the breast. (allenpress.com)
  • 4 Adenosarcoma occurring outside the female genital tract likely represents tumors arising from preexisting endometriosis. (allenpress.com)
  • 13. Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma 14. (cancer.gov)
  • What is the difference between uterine adenosarcoma and uterine adenocarcinoma? (rareguru.com)
  • Adenosarcoma of the uterine cervix presenting as a cervical polyp. (thefreedictionary.com)
  • Due to two parallel fistulas in cervix, severe endometriosis and adenosarcoma, she has undergone radical and multiple surgeries. (scirp.org)
  • Although the uterine corpus is by far the most common primary site, adenosarcoma may also arise in the cervix, ovary, fallopian tube, or vagina. (allenpress.com)
  • In many cases, patients have a history of recurrent cervical or endometrial "polyps," which, upon retrospective review, are found to be adenosarcoma. (medscape.com)
  • A new FIGO (International Federation of Gynecology and Obstetrics) staging system for adenosarcoma, identical to that for endometrial stromal sarcoma (ESS), has been devised recently 16 ( Table 1 ). (allenpress.com)
  • Some types of uterine cancer and/or endometrial cancer are known to be associated with hereditary cancer syndromes, but we are unaware of information about an association between these cancer syndromes and uterine adenosarcoma specifically. (rareguru.com)
  • The rare cases of adenosarcoma outside the female genital tract usually occur in the liver, bladder, kidney, as well as the intestine and are typically associated with endometriosis. (wikipedia.org)
  • Intraglandular polypoid projections characterize adenofibroma/adenosarcoma at low power (hematoxylin and eosin stain, x200). (medscape.com)
  • Areas displaying features of Müllerian differentiation were also documented in 6 cases, including epithelium of endometrioid, tubal, clear cell and squamous cell type as well as one case showing an architecture that closely resembled Müllerian adenofibroma and adenosarcoma. (springer.com)
  • Although almost all adenosarcomas occur in women, mesodermal adenosarcoma has been reported in a boy with persistent müllerian duct syndrome and, rarely, in the testis, seminal vesicle, and prostate. (medscape.com)
  • Adenosarcoma arises from mesenchymal tissue and has a mixture of the tumoral components of an adenoma, a tumor of epithelial origin, and a sarcoma, a tumor originating from connective tissue. (wikipedia.org)
  • There are also rare uterine mesenchymal sarcoma subtypes, including adenosarcoma, perivascular epitheliod cell tumor (PEComa) and rhabdomyosarcoma. (oncolink.org)
  • High-grade adenosarcoma is an aggressive neoplasm with propensity for short-interval recurrence and metastasis. (cdc.gov)
  • Dedifferentiated Carcinoma of the Endometrium Associated With Low-grade Müllerian Adenosarcoma: A Clinicopathologic Case Report Including the Immunohistochemical and Molecular Profile. (harvard.edu)
  • Uterine adenosarcoma commonly arise from the endometrium. (wikipedia.org)
  • Adenosarcoma arise most commonly from the endometrium, sometimes including the lower uterine segment, but some cases are situated in the endocervix and rare examples arise within the myometrium from adenomyosis. (biomedcentral.com)
  • We report a very rare case with Müllerian adenosarcoma arising from vaginal endometriosis. (scirp.org)
  • And the last two resections demonstrated vaginal adenosarcoma. (scirp.org)
  • Finally, adenosarcoma associated with endometriosis was diagnosed from recurrent vaginal masses. (scirp.org)
  • Excision of a recurrent vaginal mass revealed adenosarcoma with heterologous elements . (lookfordiagnosis.com)
  • Uterine adenosarcoma usually affects postmenopausal women, presenting with pelvic pain or vaginal bleeding but there may be no symptoms at all. (humpath.com)
  • The role for adjuvant systemic therapy for adenosarcoma, leiomyosarcoma, HGESS, or UUS is controversial and should not be considered standard of care, given there is no overall survival benefit reflected in prospective adjuvant trials. (bccancer.bc.ca)
  • Adenosarcoma with myometrial invasion recurred in 36-46% of cases. (wikipedia.org)
  • [ 5 ] Rare cases of synchronous uterine and extrauterine adenosarcoma may represent a multicentric origin linked to endometriosis rather than metastatic disease. (medscape.com)
  • To date, however, several cases of extrauterine adenosarcoma arising from a background of endometriosis have been reported (Hines et al. (springeropen.com)
  • In this brief review, we present the clinical, histopathologic, and immunohistochemical features of adenosarcoma, as well as updates on the molecular biology of this neoplasm. (allenpress.com)
  • We hypothesized that high-grade adenosarcoma has distinct clinical and molecular features, distinct from low-grade adenosarcoma. (cdc.gov)
  • Müllerian adenosarcoma is an uncommon biphasic tumor composed of malignant stromal and benign epithelial components. (allenpress.com)
  • Although uncommon, adenosarcoma affects women of a broad age range. (allenpress.com)
  • Clement PB, Scully RE (1978) Extrauterine mesodermal (müllerian) adenosarcoma. (springer.com)
  • Uterine adenosarcoma have, by definition, a malignant stroma and benign glandular elements. (wikipedia.org)
  • High-grade Müllerian Adenosarcoma: Genomic and Clinicopathologic Characterization of a Distinct Neoplasm With Prevalent TP53 Pathway Alterations and Aggressive Behavior. (harvard.edu)
  • Adenosarcoma occurs in females aged 15-90 years, with a median age at diagnosis of 58 years. (medscape.com)
  • Malignant features in epithelial component ruled out adenosarcoma , so the diagnosis of MMMT was confirmed. (thefreedictionary.com)
  • The polyp contained an adenosarcoma with sarcomatousovergrowth.The distinctive morphological features of this rare tumour are emphasized here. (manipal.edu)
  • Ovarian adenosarcoma is a very rare tumor effecting the ovaries. (wikipedia.org)
  • Symptoms of ovarian adenosarcoma include abdominal or pelvic pain and abdominal swelling. (wikipedia.org)
  • Transition between Müllerian adenosarcoma and endometriosis was gradual. (scirp.org)
  • Most of the cases reported have associated endometriosis or an adenosarcoma arising from an endometriotic area, but the direct relation between this tumor and endometriosis has not been made clear in the literature. (wikipedia.org)
  • The patient was a 44-year-old woman with advanced adenosarcoma arising from the endometriosis in the rectovaginal space and infiltrating the left pelvic wall, left ureter, rectum and vagina. (springeropen.com)
  • Dienogest may be useful for the treatment of adenosarcoma arising from endometriosis. (springeropen.com)
  • An example of an adenosarcoma is Wilms tumor. (cancer.gov)
  • Adenosarcoma **Note 3:** The FIGO stages are based on surgical staging. (cancer.gov)
  • Medroxyprogesterone acetate (MPA), a synthesized progestin, has a therapeutic effect on gynecological malignancies such as adenosarcoma (Hines et al. (springeropen.com)
  • Metanephric adenosarcoma in a young adult: morphologic, immunophenotypic, ultrastructural, and fluorescence in situ hybridization analyses: a case report and review of the literature. (thefreedictionary.com)
  • We experienced a case of advanced adenosarcoma that was insensitive to either chemotherapy or radiotherapy. (springeropen.com)
  • Primary peritoneal adenosarcoma with stromal overgrowth and fetal type cartilage: a case report and literature review. (bvsalud.org)
  • This case was the ninth case of the primary peritoneal adenosarcoma in the English literature and the first report in Thailand . (bvsalud.org)
  • We report a case of an adenosarcoma , which is a very rare type of uterine malignancy , after toremifene treatment for 5 years in a breast cancer patient . (bvsalud.org)