A malignant neoplasm arising simultaneously or consecutively in mesodermal tissue and glandular epithelium of the same part. (Stedman, 25th ed)
A tumor, basically a carcinoma with a single sarcoma such as leiomyosarcoma or angiosarcoma or multiple sarcomas of uterine origin. The role of estrogen has been postulated as a possible etiological factor in this tumor. (Holland et al., Cancer Medicine, 3d ed, p1703)
A sac or recess formed by a fold of the peritoneum.
Tumors or cancer of the UTERUS.

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. (1/18)

We previously demonstrated that AKT2, a member of protein kinase B family, is activated by a number of growth factors via Ras and PI 3-kinase signaling pathways. Here, we report the frequent activation of AKT2 in human primary ovarian cancer and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase (PI 3-kinase)/Akt pathway. In vitro AKT2 kinase assay analyses in 91 ovarian cancer specimens revealed elevated levels of AKT2 activity (>3-fold) in 33 cases (36.3%). The majority of tumors displaying activated AKT2 were high grade and stages III and IV. Immunostaining and Western blot analyses using a phospho-ser-473 Akt antibody that detects the activated form of AKT2 (AKT2 phosphorylated at serine-474) confirmed the frequent activation of AKT2 in ovarian cancer specimens. Phosphorylated AKT2 in tumor specimens localized to the cell membrane and cytoplasm but not the nucleus. To address the mechanism of AKT2 activation, we measured in vitro PI 3-kinase activity in 43 ovarian cancer specimens, including the 33 cases displaying elevated AKT2 activation. High levels of PI 3-kinase activity were observed in 20 cases, 15 of which also exhibited AKT2 activation. The remaining five cases displayed elevated AKT1 activation. Among the cases with elevated AKT2, but not PI 3-kinase activity (18 cases), three showed down-regulation of PTEN protein expression. Inhibition of PI 3-kinase/AKT2 by wortmannin or LY294002 induces apoptosis in ovarian cancer cells exhibiting activation of the PI 3-kinase/AKT2 pathway. These findings demonstrate for the first time that activation of AKT2 is a common occurrence in human ovarian cancer and that PI 3-kinase/Akt pathway may be an important target for ovarian cancer intervention.  (+info)

Mullerian adenosarcoma of the uterus with sarcomatous overgrowth following tamoxifen treatment for breast cancer. (2/18)

Mullerian adenosarcoma with sarcomatous overgrowth presented by a 52-year-old female patient after adjuvant tamoxifen treatment for breast carcinoma is described. The diagnosis was made on histological basis after curettage and complementary total hysterectomy with bilateral salpingo-oophorectomy. The immunohistochemical study showed high expression of estrogen receptors in the epithelial component of the lesion and irregularly positive findings in the stroma. The proliferative activity evaluated by Ki-67 immunoexpression was higher in the stroma than the epithelium. Some of the stromal cells showed rhabdomyoblastic differentiation. The association of tamoxifen use and development of mesenchymal neoplasms is discussed.  (+info)

Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo. (3/18)

Chlorophyllin (CHL) is a water-soluble derivative of chlorophyll, the ubiquitous pigment in green and leafy vegetables, whereas indole-3-carbinol (I3C) is present in cruciferous vegetables such as cabbage, broccoli and cauliflower. In rats initiated with 1,2-dimethylhydrazine (DMH), CHL and I3C reportedly promoted or enhanced the incidence of colon tumors when they were administered after, or during and after the carcinogen exposure, respectively. The same compounds given post-initiation inhibited the formation of colonic aberrant crypts induced by heterocyclic amines, such as 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), but tumor suppression was not examined in the latter studies. In the present investigation, male F344 rats were treated with IQ or DMH during the first 5 weeks of a 1 year study; IQ was given in the diet (0.03%), whereas DMH was administered once a week by s.c. injection (20 mg/kg body wt). Beginning 1 week after the last dose of IQ or DMH until sacrifice, rats received 0.001, 0.01 or 0.1% (w/v) CHL in the drinking water or 0.001, 0.01 or 0.1% I3C in the diet. Compared with controls given carcinogen alone, 0.1% I3C treatment suppressed the multiplicity of IQ-induced colon tumors, and CHL inhibited in a dose-related manner the incidence of IQ-induced liver tumors. However, 0.001% CHL increased significantly the multiplicity of DMH-induced colon tumors while having no effect on the colon tumors induced by IQ. These results indicate that both the choice of carcinogen as well as the dose of the tumor modulator can be important determinants of the events that occur during post-initiation exposure to CHL or I3C. Based on the present findings and data in the literature, it is possible for CHL and I3C to act as tumor promoters or anticarcinogens, depending upon the test species, initiating agent and exposure protocol.  (+info)

Mullerian adenosarcoma of the uterine cervix. (4/18)

Sarcomas in the uterine cervix are rare, the incidence being 0.5% to 1% of all cervical malignancies. This is a report of cervical mullerian adenosarcoma, which was encountered in a hysterectomy performed for prolapse. The tumor was composed of benign glandular elements and malignant stromal component, thus justifying its nomenclature. We wish to emphasize the distinctive morphological features of this rare cervical tumor.  (+info)

Expression of CD10 in malignant mullerian mixed tumors and adenosarcomas: an immunohistochemical study. (5/18)

CD10 has been demonstrated to be positive in endometrial stromal sarcoma (ESS) and thus is useful in establishing the diagnosis, but its expression in malignant mullerian mixed tumor (MMMT) and mullerian adenosarcoma remains to be clarified. In this study, 12 cases of MMMT (9 uterine, 2 tubal, and 1 metastatic), 6 cases of mullerian adenosarcoma (three corporeal, two cervical, and one tubal), and 7 cases of primary uterine sarcomas had their tissues examined immunohistochemically for expression of CD10, desmin, myoglobin, alpha-smooth muscle actin (SMA), and cytokeratin. Of the primary uterine sarcomas, two were primary rhabdomyosarcomas (one cervical and one corporeal), two were ESSs, two were high-grade leiomyosarcomas, and one was a high-grade endometrial sarcoma. Sarcomatous components in all cases of MMMT and mullerian adenosarcoma, as well as all uterine sarcomas, were positive for CD10, showing moderate to marked staining intensity with varying distribution except in one MMMT, which showed weak and very focal staining. In four MMMTs, three adenosarcomas, and one rhabdomyosarcoma, myoglobin- and/or desmin-positive rhabdomyoblastic cells were positive for CD10. The immunoreactivity for CD10 showed the same distribution for alpha-SMA and myoglobin in three and two MMMTs, respectively. In five cases of MMMT, carcinomatous components were focally positive for CD10, and in two cases small populations of round or short spindle cells in sarcomatous components were positive for CD10, alpha-SMA, and cytokeratin (CAM5.2). These results indicate that CD10 expression is not restricted to ESS but can be positive in MMMT and mullerian adenosarcoma as well as in a variety of uterine tumors including high-grade leiomyosarcoma and rhabdomyosarcoma. CD10 expression might be one of the characteristics of mullerian system-derived neoplastic mesenchymal cells.  (+info)

Therapeutic and specific antitumor immunity induced by co-administration of immature dendritic cells and adenoviral vector expressing biologically active IL-18. (6/18)

Interleukin-18 is a potent cytokine expressed early in the immune response following cleavage in activated composes. We have investigated the in vivo antitumor effects of intratumoral (i.t.) administration of an adenoviral vector expressing biologically active murine interleukin (IL)-18 (Ad.PTH.IL-18). Substantial antitumor effects were observed when established MCA205 fibrosarcoma was treated in syngeneic immunocompetent mice with intratumoral injection of Ad.PTH.IL-18 (P = 0.0025 versus control vector treatment), generating potent cytotoxic T lymphocytes (CTLs) in culture. In contrast, the antitumor effect was absent, and cytotoxic activity was significantly less (P = 0.021) in gld mice (Fas ligand deficient). To enhance the in vivo antitumor activity of the treatment using Ad.PTH.IL-18, we co-injected immature DC and Ad.PTH.IL-18 i.t. into established, day 7 MCA205 fibrosarcoma and MC38 adenocarcinoma. Co-injection of both Ad.PTH.IL-18 and DC was associated with complete abrogation of injected tumors. Furthermore, the antitumor effects were also observed on distant tumors inoculated i.d. in the contralateral flank of the animal. The induced cytolytic activity was tumor-specific and MHC class I-restricted. As we have previously demonstrated in vitro (Tanaka F et al, Cancer Res 2000; 60: 4838-4844) and consistent with these findings in vivo, NK, T and dendritic cells coactivately mediate the IL-18 enhanced antitumor effect. This study suggests that the coactivate strategy could be used in the clinical setting to treat patients with cancer. do  (+info)

Uterine neoplasia in 13 cats. (7/18)

Thirteen uterine tumors were diagnosed in 13 cats and accounted for 0.29% of all feline neoplasms received during a 9.6-year period. Age at diagnosis ranged from 3 to 16 years; median 9 years. Six were Domestic Shorthair cats, and 7 were purebred cats of 5 different breeds. Eight adenocarcinomas and 1 mixed Mullerian tumor (adenosarcoma) comprised the endometrial tumors. Myometrial tumors included 3 leiomyomas and 1 leiomyosarcoma. One of the adenocarcinomas developed in the uterine stump of an ovariohysterectomized cat; the other cats were sexually intact. Concurrent mammary adenocarcinoma was diagnosed in 1 cat with uterine adenocarcinoma and in another with uterine leiomyoma. Tumors were discovered during elective ovariohysterectomy in 2 cats, but at least 3 others had experienced reproductive problems (infertility or pyometra). Five cats presented for abdominal or pelvic masses. Endometrial adenocarcinomas were positive immunohistochemically for cytokeratins and negative for smooth muscle actin (SMA): 1 of 6 cats was positive for vimentin and 4 of 8 were positive for estrogen receptor-alpha (ER alpha). Adenosarcoma stromal cells were positive for vimentin and ER alpha but negative for cytokeratins and SMA. Smooth muscle tumors were positive for vimentin and SMA and negative for cytokeratins. Leiomyomas, but not the leiomyosarcomas, were positive for ER alpha. Adenocarcinomas in 4 cats had metastasized by the time of ovariohysterectomy. Two other cats were euthanized 5 months after ovariohysterectomy; at least one of these cats had developed an abdominal mass that was not examined histologically. Only 2 cats with endometrial adenocarcinoma had disease-free intervals longer than 5 months after surgery. Metastasis was not detected in any mesenchymal tumor; however, these cats were either euthanized on discovery of the tumor or the tumor was first detected at necropsy.  (+info)

Adenosarcoma of the uterus: a case report. (8/18)

Adenosarcomas of the uterus are very rarely observed and diagnosed. In this report, we present a case of a uterine adenosarcoma that was diagnosed in February 2002.  (+info)

Uterine adenosarcoma, also adenosarcoma of the uterus, and Müllerian adenosarcoma of the uterus, is an uncommon form of cancer that arises from mesenchymal tissue of the uterus and has a benign glandular component. The most common presentation is vaginal bleeding. Other presentations include pelvic mass and uterine polyp. Generally, the clinical findings are non-specific. Uterine adenosarcoma have, by definition, a malignant stroma and benign glandular elements. The World Health Organization (WHO) criteria have a mitotic rate cut point; however, this is often disregarded, as bland-appearing tumours with a low mitotic rate are known to metastasize occasionally. Uterine adenosarcomas are typically treated with a total abdominal hysterectomy and bilateral salpingoophorectomy (TAH-BSO). Ovary sparing surgery may be done in women wishing to preserve fertility. The prognosis is determined primarily by the cancer stage. Most tumours are discovered at an early stage and have a good prognosis, ...
MalaCards based summary : Uterine Corpus Adenosarcoma, also known as uterine corpus mullerian adenosarcoma, is related to breast myofibroblastoma and wolffian duct adenocarcinoma. An important gene associated with Uterine Corpus Adenosarcoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are Estrogen signaling pathway (KEGG) and Signaling by ERBB4. Affiliated tissues include breast, uterus and ovary ...
Mullerianadenosarcoma is an uncommon variant of mixed mesodermal tumour of the uterus. This is a case report of a 47-year-old lady who initially presented with amenorrhea followed by abnormal vaginal bleeding and a mass protruding through the os which was biopsied. Histopathological examination revealed a tumour comprising of an admixture of benign endometrial glandular component and a sarcomatous stromal component characteristic of adenosarcoma. Patient was lost to follow-up for 2 years, and returned subsequently with relapse of symptoms following which abdominal hysterectomy with polypectomy and bilateral salphingo-ooophorectomy was done. The polyp contained an adenosarcoma with sarcomatousovergrowth.The distinctive morphological features of this rare tumour are emphasized here.. ...
Dincer, A.D., Timmins, P., Pietrocola, D., et al. (2002) Primary Peritoneal Müllerian Adenosarcoma with Sarcomatous Overgrowth Associated with Endometriosis A Case Report. International Journal of Gynecological Pathology, 21, 65-68.
Uterine adenosarcoma (UA) is an extremely rare sarcoma subtype. There has been limited evaluation of the immune microenvironment in these tumors. The objective of this study is to examine and describe the immune infiltrate and PD-1/PD-L1 expression in UA and to correlate these changes in the tumor micro-environment with the overall survival status or the disease-free survival status (DFSS), respectively. Patients (pts) treated at our center from 1982 to 2014 with UA were identified. Fifteen cases had tumor paraffin-embedded blocks available. Immunohistochemistry studies for CD3, CD8, FOXP3, CD163, PD-1 and PD-L1 (clone 22C3) were performed. Image analysis was used to assess the density (cells/mm2), except in PD-L1, where the percentage of membranous staining on tumor cells was noted. Immune infiltrate analysis median (range) density in cells/mm2 varied broadly: CD3 178 (15-802); CD8 117 (11-661); FoxP3 4.8 (0.2-82); CD163 791 (264-1861); and PD1 5 (1-65). 3 cases had rare (1%) PD-L1 tumor membranous
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Contents: 1. Cytology of the uterine cervix and corpus M. Fujiwara and C. S. Kong; 2. Cervix: squamous cell carcinoma and precursors M. Fujiwara and C. S. Kong; 3. Cervix: adenocarcinoma and precursors, including variants; 4. Miscellaneous cervical abnormalities; 5. Nonneoplastic endometrium; 6. Endometrial carcinoma precursors: hyperplasia and EIN; 7. Endometrioid adenocarcinoma; 8. Serous adenocarcinoma; 9. Other uterine corpus carcinomas, including variants; 10. Carcinosarcoma; 11. Adenofibroma and adenosarcoma; 12. Uterine smooth muscle tumors; 13. Endometrial stromal tumors; 14. Other uterine mesenchymal tumors; 15. Miscellaneous primary uterine tumors; 16. Uterine metastases: cervix and corpus; 17. Gestational trophoblastic disease; 18. Other pregnancy-related abnormalities; 19. Lynch syndrome (hereditary nonpolyposis colon cancer syndrome); 20. Cytology of peritoneum and abdominal washings C. Haynes and C. S. Kong; Index.. ...
Note 1: AJCC 7th Edition TNM staging reflects the new staging adopted by the Federation Internationale de Gynecologie et dObstetrique (FIGO) and utilizes three new staging schemas for cancer of the Corpus Uteri based on histology. This is a change from the AJCC 6th Edition TNM staging. The three new schemas are: 1. Carcinoma and carcinosarcoma 2. Leiomyosarcoma and endometrial stromal sarcoma (ESS) 3. Adenosarcoma ...
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It has been reported that wild-type APC protein forms a complex with beta-Catenin and GSK3beta, inducing degradation of beta-Catenin in normal cells. Both beta-Catenin and APC gene mutations have recently been shown to activate the same signaling pathway. Frequent mutations of beta-Catenin in heredi …
Introduction. Within stage I epithelial ovarian cancer (EOC), the current clinic-pathological parameters, like tumor grade, fail to accurately stratify patient prognosis and it is therefore crucial for optimal treatment that the biological properties of stage I EOCs are further elucidated. We have previously demonstrated miR-200c as a predictor of survival, and a biomarker of relapse (Marchini et al. Lancet Oncology, 2011), suggesting that miRNA profile could be a useful tool to dissect molecular networks in stage I EOC. The aim of the current study is to identify a miRNA signature for each tumor grade, that integrated with clinical variables would be used to improve stage I patients stratification.. Experimental procedures. A cohort of 219 snap frozen tumor biopsies, with median follow up of seven years, was gathered together from three independent Italian tumor tissue collections. miRNA landscape was generated with commercially available arrays (Agilent, Palo Alto CA) and analysis performed as ...
Symptoms may be so slight the infection is only discovered by a later positive skin or blood test, or nodules on the lungs, according to a Mayo Clinic article which reads, Although the nodules typically dont cause problems, they can look like tumors on X-ray. According to this article, symptoms resemble those of the flu, sometimes accompanied by a rash, and can become chronic with low-grade fever, weight loss, cough, chest pain, and, as previously mentined, lung nodules. In its most serious form, the infection disseminates (spreads) to the skin (nodules and ulcers), bones, joints, and brain. Filipinos, Hispanics, blacks, Native Americans, and Asians, along with pregnant women, diabetics, and people with weakened immune systems are more likely to develop the serious forms of the disease according to the Mayo Clinic article.. The April, 2012, issue of St. Josephs Magazine reports that approximately one third of those exposed to the spore will contract valley fever. According to this report, ...
At the beginning of the 20th century, discoveries in cancer research began to elucidate the idiosyncratic metabolic proclivities of tumor cells1. Investigators postulated that revealing the distinct nutritional requirements of cells with unchecked growth potential would reveal targetable metabolic vulnerabilities by which their survival could be selectively curtailed. Soon thereafter, researchers in the field of immunology began drawing parallels between the metabolic characteristics of highly proliferative cancer cells and those of immune cells that respond to perceived threats to host physiology by invading tissues, clonally expanding, and generating vast amounts of pro-inflammatory effector molecules to provide the host with protection. Throughout the past decade, increasing effort has gone into elucidating the biosynthetic and bioenergetic requirements of immune cells during inflammatory responses. It is now well established that, like tumor cells, immune cells must undergo metabolic adaptations to
A CT or CAT scan (computed tomography) is a much more sensitive imaging technique than X-ray. It produces high definition images not only of the bony structures but also of the soft tissues. Clear images of organs such as the brain, muscles, joint structures, veins and arteries, as well as anomalies like tumors and hemorrhages, may be obtained with or without the injection of contrasting dye ...
MRI Scan or Magnetic Resonance Imaging Scan is a kind of a medical investigation or testing which makes use of magnetic and radio frequency waves to create an image of the body. MRI Scan is capable of taking pictures of different body parts as well as organs. The information thus generated can be seen with ultrasound, X Ray and CT scans. The advantage of MRI Scan is that it showcases problem areas which other types of imaging methods or mechanisms are not capable of producing.. In MRI Scan, the body part or organ area which needs to be focused upon is placed inside a machine which consists of a very strong magnet. In most cases, a contrast material is also used on the particular body part so as to create a more clear image. The test is done to find problems like tumors, blood vessel diseases, injuries and infections and thereby thus helps in diagnosis and treatment.. Tesla (T) is the unit of measurement which gives the strength of a magnetic field. The high-field standard was 1.5 Tesla prior to ...
Learn an ultrasound procedure, and conditions and diseases it assists in diagnosing and screening like tumors, cysts, heart conditions and more.
Diagnosis, DNA, Cancer, Ploidy, Sarcoma, Sarcomas, Chromosomal Instability, Patients, Association, Methods, Patient, Population, Report, Survival, Adenosarcomas, Beta-catenin, Endometrial Stromal Sarcomas, Leiomyosarcomas, Multivariate Analyses, Observation
Chordomas are rare neoplasms, arising from notochordal remnants in the midline skeletal axis, for which the current treatment is limited to surgery and radiotherapy. Recent reports suggest that receptor tyrosine kinases (RTK) might be essential for the survival or proliferation of chordoma cells, providing a rationale for RTK targeted therapy. Nevertheless, the reported data are conflicting, most likely due to the assorted tumor specimens used for the studies and the heterogeneous methodological approaches. In the present study, we performed a comprehensive characterization of this rare entity using a wide range of assays in search for relevant therapeutic targets. Histopathological features of 42 chordoma specimens, 21 primary and 21 advanced, were assessed by immunohistochemistry and fluorescent in situ hybridization (FISH) using PDGFRB, CSF1R, and EGFR probes. Twenty-two of these cases, for which frozen material was available (nine primary and 13 advanced tumors), were selectively analyzed using the
The S-12 fractions of lung peripheral parenchyma obtained from 80 male individuals, aged 17-71 years, were assayed as blind samples for the ability either to convert promutagens into bacterial mutagens or to decrease the potency of direct-acting mutagens in the Ames reversion test. In this system, lung preparations were completely ineffective in activating an N-nitroso compound (i.e., N-nitrosoniorpholine) and polycyclic aromatic hydrocarbons [i.e., 3-methylcholanthrene and benzo(a)pyrene] or their metabolites [i.e., 3-hydroxy-benzo(a)pyrene and benzo(a)pyrene-trans-7,8-diol]. They yielded a borderline and sporadic activation of a cigarette smoke condensate, and a weak but frequent activation of an aromatic amine (i.e., 2-aminofluorene), of a heterocyclic amine (i.e., 2-amino-3,4-dimethylimidazo[4,5-f]quinoline) and of a diamide (i.e., cyclophosphamide). The pulmonary metabolism was more oriented in the sense of detoxification, as shown by the consistent decrease of potency of direct-acting ...
Supplementary Materials [Supplemental Materials] 00783. modulation is dependant on numerous organic synergistic relationships between sarcolemmal and intracellular procedures via membrane Ca2+ and voltage. Major interactions consist of adjustments of diastolic Na+/Ca2+ exchanger current that few earlier/later on diastolic Ca2+ releases (predicting the experimentally defined LCR period shift) of increased/decreased amplitude (predicting changes in Rivaroxaban cell signaling LCR signal mass, i.e., the product of LCR spatial size, amplitude, and number per cycle) to the diastolic depolarization and ultimately to the spontaneous action potential firing rate. Concomitantly, larger/smaller and more/less frequent activation of L-type Ca2+ current shifts the cellular Ca2+ balance to support the respective Ca2+ cycling changes. In conclusion, our model simulations corroborate recent experimental results in rabbit SANCs pointing to a new paradigm for GPCR heart rate modulation by a complex system of ...
Social norms theory states that much of peoples behaviour is influenced by their perception of how other members of their social group behave. When individuals are in a state of deindividuation, they see themselves only in terms of group identity, and their behaviour is likely to be guided by group norms alone. But while group norms have a powerful effect on behaviour, they can only guide behaviour when they are activated by obvious reminders or by subtle cues. People adhere to social norms through enforcement, internalisation, the sharing of norms by other group members, and frequent activation (Smith 2007). Norms can be enforced through punishment or reward. Individuals are rewarded for living up to their roles (i.e. students getting an A on their exam) or punished for not completing the duties of their role (i.e. a salesman is fired for not selling enough product).. Social norm theory has been applied as an environmental approach, with an aim of influencing individuals by manipulating ...
Social norms theory states that much of peoples behaviour is influenced by their perception of how other members of their social group behave. When individuals are in a state of deindividuation, they see themselves only in terms of group identity, and their behaviour is likely to be guided by group norms alone. But while group norms have a powerful effect on behaviour, they can only guide behaviour when they are activated by obvious reminders or by subtle cues. People adhere to social norms through enforcement, internalisation, the sharing of norms by other group members, and frequent activation (Smith 2007). Norms can be enforced through punishment or reward. Individuals are rewarded for living up to their roles (i.e. students getting an A on their exam) or punished for not completing the duties of their role (i.e. a salesman is fired for not selling enough product). Social norm theory has been applied as an environmental approach, with an aim of influencing individuals by manipulating their ...
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Discussing the premise of the study, lead investigator Frédéric Amant (Leuven Cancer Institute, Belgium) commented: We wanted to generate a clear view on the presence of targetable proteins in all subtypes of uterine sarcomas, with the aim of improving treatment options for these patients. Identifying biomarkers is crucial because novel treatments are expensive, underscoring the importance of patient selection.. The investigating team assessed five proteins in 288 samples of uterine sarcoma. In terms of subtypes, these samples included 157 leiomyosarcomas, 52 benign uterine stromal tumors and 41 normal uterine tissues. The remaining samples consisted of endometrial sarcomas, adenosarcomas and other undifferentiated types of uterine sarcoma.. These analyses uncovered that activated P-S6S240 is more often found expressed in high-grade tumors when compared with low-grade tumors - 32% vs 9%, respectively. Given that P-S6S240 is involved in the PI3K/mTOR cell signaling pathway, the team went on ...
|p|Douglas David was born in 1971 into the Nuu-chah-nulth nation, on his father’s side and the Sioux Dakota nation on his mother’s side. Both his parents are artists, and from birth Douglas has been exposed to the traditional art of these cultures. At the age of eight Douglas realized his visions could be transferred from thought to hand and has been carving ever since. Douglas acknowledges his father Joe David, a renowned master carver along with Douglas’s mother and ancestral spirits as his teachers and mentors.|/p||p|Douglas’s specific crests belonging to the Nuu Chah Nulth nation are the Wolf, Killerwhale, and Thunderbird. These crest images are prevalent in his works on wood and raw hide. Douglas currently resides in Port Alberni with his wife, Angela and their seven children. |/p| |p| Douglas is an experienced carver and his works are in various collections worldwide. He is considered part of the next generation of master artists of the Northwest Coast. |/p|
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Round 5 saw the PRO-4 races lined up for sixteen laps round the .7-mile temporary circuit that was created on and inside the Route 66 Dirt Track. The starting inversion saw Douglas start from the second row. When the race went green, the AMSOIL PRO-4 was in a heated battle for the lead. There was plenty of pushing and shoving that went on during the first eight laps and it continued after the mandatory caution. Then the race was red flagged when another racer took down the AMSOIL finish line arch. During this time the crew noticed the race truck had cut a tire from all the racing contact. When the race began moving under caution, Douglas headed for the Hot Pits. The Douglas Motorsports crew quickly replaced the tire, but now the #7 Pro-4 was at the tail end of the field.. When the green flag waved for the final seven laps, Douglas really turned up the wick. On lap 12, he set the fastest lap of the night. When the checkered flag was waved, Scott Douglas occupied the final spot on the ...
NOTICE OF PUBLIC MEETING OF THE DOUGLAS COUNTY BOARD OF HEALTH The Douglas County Board of Health will meet at 8:00 a.m. on Wednesday, August 19, 2020, at the Health Department at 1111 S. 41st Street, Room 205, and available via live streaming on … Office Location Opportunity to Comment on Project PARTNER on Ava. ACTION: SOLICITATION OF 30-DAY COMMENTS and NOTICE OF PUBLIC MEETING Opportunity to Comment on Project PARTNER on Ava. All Douglas County Libraries locations are open with modified hours, services, and safety protocols. Northern Douglas County Water And Sanitation District . Find property records, vital records, inmate and court records, professional and business licenses, contractor licenses and much more. The meetings will be held at the Omaha-Douglas Civic Center, 1819 Farnam, Legislative Chamber, Omaha, NE. The legal notices posted on this site are for reference only. Public Notices. Help; Connect. For additional information contact the Douglas County Commission at 417-683-6080. ...
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Port Douglas Day Spa, Port Douglas: See 89 reviews, articles, and 12 photos of Port Douglas Day Spa, ranked No.7 on TripAdvisor among 20 attractions in Port Douglas.
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No matter the condition, Douglas Labs has a natural solution. Arthritis problems, energy depletion, aging, memory loss and more can lower your quality of life. Good nutrition and exercise, along with supplements from Douglas Labs, can aid in helping as well as preventing various aches, pains and problems. Douglas Labs also provides vitamins that need to be incorporated into everyday diets. Choose from vitamins A, B-12, C, E and more. We also carry supplements like Riboflavin, Zinc, Potassium and Niacin if you need to add more of these to your diet ...
18 de Dez de 2017 - Alugue de pessoas em Port Douglas, Austrália a partir de R$66/noite. Encontre lugares únicos para se hospedar com anfitriões locais em 191 . O mundo é a sua casa com o Airbnb.
Douglas Allen is Managing Director of the Ethisphere Institute, where he leads benchmarking, certification, and partnership efforts. Previously, Douglas spent six years with providing compliance- and ethics-related advisory services, including developing compliance and ethics risk assessments, codes of conduct, corporate policies and procedures, and communication and training curriculum plans. Douglas received his Bachelors from the University of Arizona and Masters of Business Administration from the University of Notre Dame.. ...
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ENT-related issues of the head and neck. ENT specialists are trained to manage diseases, like tumors, trauma, and deformities of the head, neck, and face. They can perform cosmetic and reconstructive surgery in these areas, too. They can also manage problems with the nerves in the head and neck which controls sight, smelling, hearing, and facial movements ...
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After months of radiation and chemotherapy for late-stage throat cancer, actor Michael Douglas is tumor-free, he told NBCs Today Show viewers this morning. But researchers caution that the 66-year-old Douglas is hardly out of the woods.
Actor, writer, and director Illeana Douglas is the granddaughter of two-time Academy Award-winning actor Melvyn Douglas. She has starred in Cape Fear (1991), To Die For (1995), Grace of My Heart (1996), Picture Perfect (1997), and Ghost World (2001). In addition to her acting, she serves as the host of Trailblazing Women, which will premiere its second season on Turner Classic Movies in October 2016. Her memoir, I Blame Dennis Hopper, was named one of the top ten books of 2015 by Entertainment Weekly.
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Emory Douglas is a key figure in the Black Panther Party. From 1967 to the 1980s, Douglas was involved with the Party after recognizing the need for self-defense, which is what the Panthers focused on from the beginning. After linking up with the co-founders Huey P. Newton and Bobby Seale just mere months after the for
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Frases de Kirk Douglas ✅ Descubra citações e frases curtas interessantes e verificadas · Kirk Douglas, nome artístico de Issur Danielovitch , é um ator e produtor cinem…
Actor Michael Douglas said his throat cancer, originally thought to be due to years of smoking and drinking, was caused by oral sex.
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The sample was sent to the U.S. Centers for Disease Control and Prevention at the end of January by medical officials in Douglas County.
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The Douglas County MN Maintenance Department is responsible for maintaining the building and grounds of the County Courthouse and Services Center.
Ostör AG, Nirenberg A, Ashdown ML, Murphy DJ (June 1994). "Extragenital adenosarcoma arising in the pouch of Douglas". ...
Adenosarcoma Uterine adenosarcoma Zidar N, Gale N (2015). "Carcinosarcoma and spindle cell carcinoma--monoclonal neoplasms ...
She was later diagnosed with adenosarcoma, and died from leukemia. Jean Keene (1923-2009; aged 85), American activist and rodeo ...
Katz was subsequently diagnosed with a rare form of uterine cancer called adenosarcoma in June 2004, following a hysterectomy. ...
Müllerian adenosarcoma Uterine high-grade leiomyosarcoma Uterine rhabdomyosarcoma Vascular tumors Epithelioid ...
... adenosarcoma MeSH C04.557.450.795.290 - carcinosarcoma MeSH C04.557.450.795.290.210 - carcinoma 256, walker MeSH C04.557. ... adenosarcoma MeSH C04.557.435.250 - carcinoma, adenosquamous MeSH C04.557.435.290 - carcinosarcoma MeSH C04.557.435.290.210 - ...
NOS M8932/0 Adenomyoma Atypical polypoid adenomyoma M8933/3 Adenosarcoma M8934/3 Carcinofibroma M8935/0 Stromal tumor, benign ...
... though adenosarcoma can arise in the cervix. Symptoms of cervical adenosarcoma, like uterine adenosarcoma, are characterized by ... Adenosarcoma (also Mullerian Adenosarcoma) is a rare malignant tumor that occurs in women of all age groups, but most commonly ... Mullerian adenosarcoma with sarcomatous overgrowth is a very aggressive form of adenosarcoma that is characterized by post- ... 1998;5(4):939-944 McCluggage, Glenn W. "Uterine Adenosarcoma." Uterine Adenosarcoma, Department of Pathology, Royal Group of ...
... is an uncommon form of cancer that arises from mesenchymal tissue of the uterus and has a benign glandular ... 2010). "Mullerian adenosarcoma of the uterus: a rare neoplasm with a need for onco-fertility". Eur J Gynaecol Oncol. 31 (6): ... Uterine adenosarcoma have, by definition, a malignant stroma and benign glandular elements. The World Health Organization (WHO ... Mar 2010). "Mullerian adenosarcoma of the female genital tract". Adv Anat Pathol. 17 (2): 122-9. doi:10.1097/PAP. ...
Adenosarcoma is a biphasic neoplasm composed of malignant stroma and benign epithelium. Adenofibroma is a biphasic neoplasm ... encoded search term (Uterus Adenofibroma/Adenosarcoma Pathology) and Uterus Adenofibroma/Adenosarcoma Pathology What to Read ... Adenosarcoma occurs in females aged 15-90 years, with a median age at diagnosis of 58 years. [2, 3, 4, 5, 6, 7, 8, 9] Most ... Uterus Adenofibroma/Adenosarcoma Pathology Updated: May 01, 2017 * Author: Peggy S Sullivan, MD; Chief Editor: Ramya Masand, MD ...
... though adenosarcoma can arise in the cervix. Symptoms of cervical adenosarcoma, like uterine adenosarcoma, are characterized by ... Adenosarcoma (also Mullerian Adenosarcoma) is a rare malignant tumor that occurs in women of all age groups, but most commonly ... Mullerian adenosarcoma with sarcomatous overgrowth is a very aggressive form of adenosarcoma that is characterized by post- ... 1998;5(4):939-944 McCluggage, Glenn W. "Uterine Adenosarcoma." Uterine Adenosarcoma, Department of Pathology, Royal Group of ...
Alternative Treatments for Adenosarcoma are available at New Hope Unlimited. To learn more information about Adenosarcoma, ... Types of Adenosarcoma We Treat at New Hope. Adenosarcoma can develop in different organs of the body. It is most prevalent in ... Adenosarcoma Symptomss. Signs of adenosarcoma vary and may include recurrent pain and discomfort, unusual lumps in the body, ... Alternative Treatments for Adenosarcoma: Expert Care That Works. Survive Adenosarcoma. At New Hope Unlimited, our ...
Bhandare D, Madiwale C, Kothari K, Pandit A, Kane S. Mullerian adenosarcoma of the uterine cervix. Indian Journal of Pathology ... This is a report of cervical mullerian adenosarcoma, which was encountered in a hysterectomy performed for prolapse. The tumor ...
4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul 06044, ...
Diagnosis: Adenosarcoma Week 131: Case 2. Diagnosis: Adenosarcoma Week 37: Case 3. Diagnosis: Adenosarcoma ... Search by Diagnosis: "Adenosarcoma". Show Diagnoses. Week 587: Case 1. ...
Uterine Sarcomas (Leiomyosarcoma, Endometrial Stromal Sarcoma, and Adenosarcoma) (Open Table in a new window) ...
Mullerian adenosarcoma with sarcomatous overgrowth (MASO) is a rare variant of uterine sarcomas, associated with postoperative ... Uterine mullerian adenosarcoma with sarcomatous overgrowth fatal recurrence within two weeks of diagnosis: a case report. * ... Farhat, M.H., Hobeika, E.M., Moumneh, G. et al. Uterine mullerian adenosarcoma with sarcomatous overgrowth fatal recurrence ... Uterine mullerian adenosarcoma with sarcomatous overgrowth fatal recurrence within two weeks of diagnosis: a case report ...
Adenosarcoma of the Corpus Uteri; Uterus, NOS Primary Site. Histology. Staging Type. ... TNM stages are based on clinical and/or pathologic classification). **Note 4:** This schema is for adenosarcoma ONLY. When ... Adenosarcoma **Note 3:** The FIGO stages are based on surgical staging. ( ...
I have been diagnosed with a cancer Mullerian adenosarcoma last Saturday. Since it is very rare and incurable in Mauritius, I ... I have been diagnosed with a cancer Mullerian adenosarcoma last Saturday. Since it is very rare and incurable in Mauritius, I ... Support Noelleta Boodoo, diagnosed with a Mullerian Adenosarcoma ( an uncommon mixed tumor) , an urgent surgery is required ... Support Noelleta Boodoo, diagnosed with a Mullerian Adenosarcoma ( an uncommon mixed tumor) , an urgent surgery is required ...
D. Adenosarcoma. Vote. .formPoll , div { box-shadow: 0 0 5px 2px #9b9b9b6b; border-radius: 5px; display: flex; flex-direction: ...
Targeted genomic analysis of Müllerian adenosarcoma. The Journal of pathology Howitt, B. E., Sholl, L. M., Dal Cin, P., Jia, Y ... Mullerian Adenosarcoma: Clinicopathologic Features of 78 cases Kolin, D., Howitt, B., Nathenson, M., Nucci, M. NATURE ... Mullerian Adenosarcoma: Clinicopathologic Features of 78 cases Kolin, D., Howitt, B., Nathenson, M., Nucci, M. NATURE ... Involvement of Chromosome 8 in Müllerian Adenosarcoma. International journal of gynecological pathology : official journal of ...
Müllerian adenosarcoma is a malignant polypoid lesion of the cervix with a pattern of benign endocervical glands and a spindle ... The histopathology is similar to cervical embryonal rhabdomyosarcoma with overlapping features of adenosarcoma [Bean et al 2019 ... Embryonal rhabdomyosarcoma of the cervix or other sites with features of adenosarcoma ...
Uterine Sarcomas (Leiomyosarcoma, Endometrial Stromal Sarcoma, and Adenosarcoma). Table. Uterine Sarcomas (Leiomyosarcoma, ...
I am 27 years old and I was diagnosed with adenosarcoma about 2 weeks ago. They want to do a full hysterectomy but keep going ... I am 27 years old and I was diagnosed with adenosarcoma about 2 weeks ago. They want to do a full hysterectomy but keep going ...
Adenosarcoma of the uterus: A gynecologic oncology group clinicopathologic study of 31 cases. Kaku, T., Silverberg, S. G., ...
M]Adenosarcoma Current Synonym true false 52608010 Adenosarcoma Current Synonym true false ...
Early HM, McGahan JP, Naderi S, Lamba R, Fananapazir G. Müllerian Adenosarcoma: A Malignant Progression of Adenomyosis? ...
Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03 ...
Uterine Sarcomas (Leiomyosarcoma, Endometrial Stromal Sarcoma, and Adenosarcoma). Table. Uterine Sarcomas (Leiomyosarcoma, ...
DDx: *[[Adenosarcoma]]. ===IHC=== *Desmin +ve (common). *SMA usu. -ve. ==Adenosarcoma== {{Main,Adenosarcoma}} ==See also== *[[ ... DDx: *[[Adenosarcoma]]. ==Fibroepithelial stromal polyp== ===General=== *Usually easy to recognize.,ref name=pmid10680891/> === ... Adenosarcoma]]. *[[Papillary adenofibroma of the uterine cervix]].,ref name=pmid8927449>{{Cite journal , last1 = Fratini , ...
Adenosarcoma. *Bladder Cancer - (Also see: Purple, Blue and Marigold ribbon below). *Bone cancer / Osteosarcoma ...
A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. Embeddings are generated with Walking RDF and OWL method ...
Mullerian adenosarcoma:1,,Nestin:1,,Normal endometrium:1,,Oncofertility:1,,Oncologic outcome:1,,Oocyte cryopreservation:1,, ...
A case of ovarian adenosarcoma with a heterologous rhabdomyosarcoma component: A brief case report [1]. Mikami, M., Tanaka, K. ...
  • Mullerian adenosarcoma with sarcomatous overgrowth is a very aggressive form of adenosarcoma that is characterized by post-operative recurrence and metastases even when diagnosed at an early stage. (wikipedia.org)
  • Mullerian adenosarcoma with sarcomatous overgrowth (MASO) is a rare variant of uterine sarcomas, associated with postoperative recurrence, metastases and a fatal outcome. (biomedcentral.com)
  • Adenosarcoma (also Mullerian Adenosarcoma) is a rare malignant tumor that occurs in women of all age groups, but most commonly post-menopause. (wikipedia.org)
  • Adenosarcoma arises from mesenchymal tissue and has a mixture of the tumoral components of an adenoma, a tumor of epithelial origin, and a sarcoma, a tumor originating from connective tissue. (wikipedia.org)
  • Sarcomatous overgrowth is diagnosed when the sarcomatous portion of the adenosarcoma makes up more than 25% of the tumor. (wikipedia.org)
  • Ovarian adenosarcoma is a very rare tumor effecting the ovaries. (wikipedia.org)
  • Most of the cases reported have associated endometriosis or an adenosarcoma arising from an endometriotic area, but the direct relation between this tumor and endometriosis has not been made clear in the literature. (wikipedia.org)
  • Haydarpaşa Numune Hastanesi, Patolojik Anatomi Laboratuarı, İstanbul Mullerian Adenosarcoma is a phasic uterine tumor composed of benign epithelial and malign stromal components. (onkder.org)
  • Intraglandular polypoid projections characterize adenofibroma/adenosarcoma at low power (hematoxylin and eosin stain, x200). (medscape.com)
  • The prognosis of uterine adenosarcoma depends on the stage and if sarcomatous overgrowth is present. (wikipedia.org)
  • The most common clinical feature of adenosarcoma is abnormal vaginal bleeding, many times associated with an enlarged uterus, pelvic pain, and tissue protruding from the cervical os. (medscape.com)
  • New Hope Unlimited is one of the most active centers for the treatment of malignant disorders, including adenosarcoma. (newhopemedicalcenter.com)
  • Uterine adenosarcoma commonly arise from the endometrium. (wikipedia.org)
  • A case of mullerian adenosarcoma of endometrium. (ogscience.org)
  • IMSEAR at SEARO: Mullerian adenosarcoma of the uterine cervix. (who.int)
  • The most common site of adenosarcoma formation is the uterus, but it can also occur in the cervix and ovaries. (wikipedia.org)
  • The rare cases of adenosarcoma outside the female genital tract usually occur in the liver, bladder, kidney, as well as the intestine and are typically associated with endometriosis. (wikipedia.org)
  • In many cases, patients have a history of recurrent cervical or endometrial "polyps," which, upon retrospective review, are found to be adenosarcoma. (medscape.com)
  • This is a report of cervical mullerian adenosarcoma, which was encountered in a hysterectomy performed for prolapse. (who.int)
  • [ 5 ] Rare cases of synchronous uterine and extrauterine adenosarcoma may represent a multicentric origin linked to endometriosis rather than metastatic disease. (medscape.com)
  • Uterine adenosarcoma are a subtype of uterine sarcomas. (wikipedia.org)
  • Uterine sarcomas generally account for less than 4% of all uterine malignancies with the subtype adenosarcoma comprising only 8% of cases, reflecting the rarity of this entity [ 1 ]. (biomedcentral.com)
  • Early and correct diagnosis is crucial to improving your adenosarcoma prognosis and life expectancy. (newhopemedicalcenter.com)
  • Adenosarcoma occurs in females aged 15-90 years, with a median age at diagnosis of 58 years. (medscape.com)
  • The diagnosis was adenosarcoma. (onkder.org)
  • Because of the rarity of adenosarcoma, there is limited data to guide treatment decisions, particularly in regard to recurrent or metastatic tumors. (wikipedia.org)
  • Signs of adenosarcoma vary and may include recurrent pain and discomfort, unusual lumps in the body, and bleeding from the vagina (Müllerian adenosarcoma). (newhopemedicalcenter.com)
  • Symptoms of ovarian adenosarcoma include abdominal or pelvic pain and abdominal swelling. (wikipedia.org)
  • Although almost all adenosarcomas occur in women, mesodermal adenosarcoma has been reported in a boy with persistent müllerian duct syndrome and, rarely, in the testis, seminal vesicle, and prostate. (medscape.com)
  • It is important to note that adenosarcoma can occur elsewhere in the body. (newhopemedicalcenter.com)
  • Your signs and symptoms may or may not be because of adenosarcoma, in which only a medical professional can determine. (newhopemedicalcenter.com)
  • Adenosarcoma with myometrial invasion recurred in 36-46% of cases. (wikipedia.org)
  • I have been diagnosed with a cancer Mullerian adenosarcoma last Saturday. (crowdfund.mu)
  • Adenosarcoma **Note 3:** The FIGO stages are based on surgical staging. (cancer.gov)
  • Note 4:** This schema is for adenosarcoma ONLY. (cancer.gov)
  • Objective This study aimed to identify the hormonal receptor status in uterine adenosarcoma (AS) and uterine AS with sarcomatous overgrowth (AS + SO), including those with high-grade histologic features (nuclear pleomorphism, atypical mitoses, necrosis), with or without heterologous elements. (bmj.com)
  • Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03/30/2018) 14. (ucsd.edu)