Adenosarcoma: A malignant neoplasm arising simultaneously or consecutively in mesodermal tissue and glandular epithelium of the same part. (Stedman, 25th ed)Mixed Tumor, Mullerian: A tumor, basically a carcinoma with a single sarcoma such as leiomyosarcoma or angiosarcoma or multiple sarcomas of uterine origin. The role of estrogen has been postulated as a possible etiological factor in this tumor. (Holland et al., Cancer Medicine, 3d ed, p1703)Douglas' Pouch: A sac or recess formed by a fold of the peritoneum.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Hysterectomy: Excision of the uterus.Uterine Neoplasms: Tumors or cancer of the UTERUS.Gift Giving: The bestowing of tangible or intangible benefits, voluntarily and usually without expectation of anything in return. However, gift giving may be motivated by feelings of ALTRUISM or gratitude, by a sense of obligation, or by the hope of receiving something in return.Clothing: Fabric or other material used to cover the body.Data Collection: Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.Gamete Intrafallopian Transfer: A technique that came into use in the mid-1980's for assisted conception in infertile women with normal fallopian tubes. The protocol consists of hormonal stimulation of the ovaries, followed by laparoscopic follicular aspiration of oocytes, and then the transfer of sperm and oocytes by catheterization into the fallopian tubes.Awareness: The act of "taking account" of an object or state of affairs. It does not imply assessment of, nor attention to the qualities or nature of the object.Protective Clothing: Clothing designed to protect the individual against possible exposure to known hazards.Sunscreening Agents: Chemical or physical agents that protect the skin from sunburn and erythema by absorbing or blocking ultraviolet radiation.BooksOrientia tsutsugamushi: A gram-negative, rod-shaped to coccoid bacterium. It is the etiologic agent of SCRUB TYPHUS in humans and is transmitted by mites from rodent reservoirs.Gynecology: A medical-surgical specialty concerned with the physiology and disorders primarily of the female genital tract, as well as female endocrinology and reproductive physiology.Scrub Typhus: An acute infectious disease caused by ORIENTIA TSUTSUGAMUSHI. It is limited to eastern and southeastern Asia, India, northern Australia, and the adjacent islands. Characteristics include the formation of a primary cutaneous lesion at the site of the bite of an infected mite, fever lasting about two weeks, and a maculopapular rash.Book SelectionBook Reviews as Topic: Critical analyses of books or other monographic works.Students: Individuals enrolled in a school or formal educational program.ColoradoMaximum Tolerated Dose: The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Platelet Membrane Glycoproteins: Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Platelet Aggregation: The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Pelvic Pain: Pain in the pelvic region of genital and non-genital origin and of organic or psychogenic etiology. Frequent causes of pain are distension or contraction of hollow viscera, rapid stretching of the capsule of a solid organ, chemical irritation, tissue ischemia, and neuritis secondary to inflammatory, neoplastic, or fibrotic processes in adjacent organs. (Kase, Weingold & Gershenson: Principles and Practice of Clinical Gynecology, 2d ed, pp479-508)Diagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.Prostatitis: Infiltration of inflammatory cells into the parenchyma of PROSTATE. The subtypes are classified by their varied laboratory analysis, clinical presentation and response to treatment.Dysmenorrhea: Painful menstruation.Spasms, Infantile: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)Cellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Genital Neoplasms, Male: Tumor or cancer of the MALE GENITALIA.Practice Guidelines as Topic: Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Guidelines as Topic: A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.Crowdsourcing: Social media model for enabling public involvement and recruitment in participation. Use of social media to collect feedback and recruit volunteer subjects.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Vocabulary, Controlled: A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)Unified Medical Language System: A research and development program initiated by the NATIONAL LIBRARY OF MEDICINE to build knowledge sources for the purpose of aiding the development of systems that help health professionals retrieve and integrate biomedical information. The knowledge sources can be used to link disparate information systems to overcome retrieval problems caused by differences in terminology and the scattering of relevant information across many databases. The three knowledge sources are the Metathesaurus, the Semantic Network, and the Specialist Lexicon.Educational Measurement: The assessing of academic or educational achievement. It includes all aspects of testing and test construction.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Carpus, Animal: The region corresponding to the human WRIST in non-human ANIMALS.

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. (1/18)

We previously demonstrated that AKT2, a member of protein kinase B family, is activated by a number of growth factors via Ras and PI 3-kinase signaling pathways. Here, we report the frequent activation of AKT2 in human primary ovarian cancer and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase (PI 3-kinase)/Akt pathway. In vitro AKT2 kinase assay analyses in 91 ovarian cancer specimens revealed elevated levels of AKT2 activity (>3-fold) in 33 cases (36.3%). The majority of tumors displaying activated AKT2 were high grade and stages III and IV. Immunostaining and Western blot analyses using a phospho-ser-473 Akt antibody that detects the activated form of AKT2 (AKT2 phosphorylated at serine-474) confirmed the frequent activation of AKT2 in ovarian cancer specimens. Phosphorylated AKT2 in tumor specimens localized to the cell membrane and cytoplasm but not the nucleus. To address the mechanism of AKT2 activation, we measured in vitro PI 3-kinase activity in 43 ovarian cancer specimens, including the 33 cases displaying elevated AKT2 activation. High levels of PI 3-kinase activity were observed in 20 cases, 15 of which also exhibited AKT2 activation. The remaining five cases displayed elevated AKT1 activation. Among the cases with elevated AKT2, but not PI 3-kinase activity (18 cases), three showed down-regulation of PTEN protein expression. Inhibition of PI 3-kinase/AKT2 by wortmannin or LY294002 induces apoptosis in ovarian cancer cells exhibiting activation of the PI 3-kinase/AKT2 pathway. These findings demonstrate for the first time that activation of AKT2 is a common occurrence in human ovarian cancer and that PI 3-kinase/Akt pathway may be an important target for ovarian cancer intervention.  (+info)

Mullerian adenosarcoma of the uterus with sarcomatous overgrowth following tamoxifen treatment for breast cancer. (2/18)

Mullerian adenosarcoma with sarcomatous overgrowth presented by a 52-year-old female patient after adjuvant tamoxifen treatment for breast carcinoma is described. The diagnosis was made on histological basis after curettage and complementary total hysterectomy with bilateral salpingo-oophorectomy. The immunohistochemical study showed high expression of estrogen receptors in the epithelial component of the lesion and irregularly positive findings in the stroma. The proliferative activity evaluated by Ki-67 immunoexpression was higher in the stroma than the epithelium. Some of the stromal cells showed rhabdomyoblastic differentiation. The association of tamoxifen use and development of mesenchymal neoplasms is discussed.  (+info)

Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo. (3/18)

Chlorophyllin (CHL) is a water-soluble derivative of chlorophyll, the ubiquitous pigment in green and leafy vegetables, whereas indole-3-carbinol (I3C) is present in cruciferous vegetables such as cabbage, broccoli and cauliflower. In rats initiated with 1,2-dimethylhydrazine (DMH), CHL and I3C reportedly promoted or enhanced the incidence of colon tumors when they were administered after, or during and after the carcinogen exposure, respectively. The same compounds given post-initiation inhibited the formation of colonic aberrant crypts induced by heterocyclic amines, such as 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), but tumor suppression was not examined in the latter studies. In the present investigation, male F344 rats were treated with IQ or DMH during the first 5 weeks of a 1 year study; IQ was given in the diet (0.03%), whereas DMH was administered once a week by s.c. injection (20 mg/kg body wt). Beginning 1 week after the last dose of IQ or DMH until sacrifice, rats received 0.001, 0.01 or 0.1% (w/v) CHL in the drinking water or 0.001, 0.01 or 0.1% I3C in the diet. Compared with controls given carcinogen alone, 0.1% I3C treatment suppressed the multiplicity of IQ-induced colon tumors, and CHL inhibited in a dose-related manner the incidence of IQ-induced liver tumors. However, 0.001% CHL increased significantly the multiplicity of DMH-induced colon tumors while having no effect on the colon tumors induced by IQ. These results indicate that both the choice of carcinogen as well as the dose of the tumor modulator can be important determinants of the events that occur during post-initiation exposure to CHL or I3C. Based on the present findings and data in the literature, it is possible for CHL and I3C to act as tumor promoters or anticarcinogens, depending upon the test species, initiating agent and exposure protocol.  (+info)

Mullerian adenosarcoma of the uterine cervix. (4/18)

Sarcomas in the uterine cervix are rare, the incidence being 0.5% to 1% of all cervical malignancies. This is a report of cervical mullerian adenosarcoma, which was encountered in a hysterectomy performed for prolapse. The tumor was composed of benign glandular elements and malignant stromal component, thus justifying its nomenclature. We wish to emphasize the distinctive morphological features of this rare cervical tumor.  (+info)

Expression of CD10 in malignant mullerian mixed tumors and adenosarcomas: an immunohistochemical study. (5/18)

CD10 has been demonstrated to be positive in endometrial stromal sarcoma (ESS) and thus is useful in establishing the diagnosis, but its expression in malignant mullerian mixed tumor (MMMT) and mullerian adenosarcoma remains to be clarified. In this study, 12 cases of MMMT (9 uterine, 2 tubal, and 1 metastatic), 6 cases of mullerian adenosarcoma (three corporeal, two cervical, and one tubal), and 7 cases of primary uterine sarcomas had their tissues examined immunohistochemically for expression of CD10, desmin, myoglobin, alpha-smooth muscle actin (SMA), and cytokeratin. Of the primary uterine sarcomas, two were primary rhabdomyosarcomas (one cervical and one corporeal), two were ESSs, two were high-grade leiomyosarcomas, and one was a high-grade endometrial sarcoma. Sarcomatous components in all cases of MMMT and mullerian adenosarcoma, as well as all uterine sarcomas, were positive for CD10, showing moderate to marked staining intensity with varying distribution except in one MMMT, which showed weak and very focal staining. In four MMMTs, three adenosarcomas, and one rhabdomyosarcoma, myoglobin- and/or desmin-positive rhabdomyoblastic cells were positive for CD10. The immunoreactivity for CD10 showed the same distribution for alpha-SMA and myoglobin in three and two MMMTs, respectively. In five cases of MMMT, carcinomatous components were focally positive for CD10, and in two cases small populations of round or short spindle cells in sarcomatous components were positive for CD10, alpha-SMA, and cytokeratin (CAM5.2). These results indicate that CD10 expression is not restricted to ESS but can be positive in MMMT and mullerian adenosarcoma as well as in a variety of uterine tumors including high-grade leiomyosarcoma and rhabdomyosarcoma. CD10 expression might be one of the characteristics of mullerian system-derived neoplastic mesenchymal cells.  (+info)

Therapeutic and specific antitumor immunity induced by co-administration of immature dendritic cells and adenoviral vector expressing biologically active IL-18. (6/18)

Interleukin-18 is a potent cytokine expressed early in the immune response following cleavage in activated composes. We have investigated the in vivo antitumor effects of intratumoral (i.t.) administration of an adenoviral vector expressing biologically active murine interleukin (IL)-18 (Ad.PTH.IL-18). Substantial antitumor effects were observed when established MCA205 fibrosarcoma was treated in syngeneic immunocompetent mice with intratumoral injection of Ad.PTH.IL-18 (P = 0.0025 versus control vector treatment), generating potent cytotoxic T lymphocytes (CTLs) in culture. In contrast, the antitumor effect was absent, and cytotoxic activity was significantly less (P = 0.021) in gld mice (Fas ligand deficient). To enhance the in vivo antitumor activity of the treatment using Ad.PTH.IL-18, we co-injected immature DC and Ad.PTH.IL-18 i.t. into established, day 7 MCA205 fibrosarcoma and MC38 adenocarcinoma. Co-injection of both Ad.PTH.IL-18 and DC was associated with complete abrogation of injected tumors. Furthermore, the antitumor effects were also observed on distant tumors inoculated i.d. in the contralateral flank of the animal. The induced cytolytic activity was tumor-specific and MHC class I-restricted. As we have previously demonstrated in vitro (Tanaka F et al, Cancer Res 2000; 60: 4838-4844) and consistent with these findings in vivo, NK, T and dendritic cells coactivately mediate the IL-18 enhanced antitumor effect. This study suggests that the coactivate strategy could be used in the clinical setting to treat patients with cancer. do  (+info)

Uterine neoplasia in 13 cats. (7/18)

Thirteen uterine tumors were diagnosed in 13 cats and accounted for 0.29% of all feline neoplasms received during a 9.6-year period. Age at diagnosis ranged from 3 to 16 years; median 9 years. Six were Domestic Shorthair cats, and 7 were purebred cats of 5 different breeds. Eight adenocarcinomas and 1 mixed Mullerian tumor (adenosarcoma) comprised the endometrial tumors. Myometrial tumors included 3 leiomyomas and 1 leiomyosarcoma. One of the adenocarcinomas developed in the uterine stump of an ovariohysterectomized cat; the other cats were sexually intact. Concurrent mammary adenocarcinoma was diagnosed in 1 cat with uterine adenocarcinoma and in another with uterine leiomyoma. Tumors were discovered during elective ovariohysterectomy in 2 cats, but at least 3 others had experienced reproductive problems (infertility or pyometra). Five cats presented for abdominal or pelvic masses. Endometrial adenocarcinomas were positive immunohistochemically for cytokeratins and negative for smooth muscle actin (SMA): 1 of 6 cats was positive for vimentin and 4 of 8 were positive for estrogen receptor-alpha (ER alpha). Adenosarcoma stromal cells were positive for vimentin and ER alpha but negative for cytokeratins and SMA. Smooth muscle tumors were positive for vimentin and SMA and negative for cytokeratins. Leiomyomas, but not the leiomyosarcomas, were positive for ER alpha. Adenocarcinomas in 4 cats had metastasized by the time of ovariohysterectomy. Two other cats were euthanized 5 months after ovariohysterectomy; at least one of these cats had developed an abdominal mass that was not examined histologically. Only 2 cats with endometrial adenocarcinoma had disease-free intervals longer than 5 months after surgery. Metastasis was not detected in any mesenchymal tumor; however, these cats were either euthanized on discovery of the tumor or the tumor was first detected at necropsy.  (+info)

Adenosarcoma of the uterus: a case report. (8/18)

Adenosarcomas of the uterus are very rarely observed and diagnosed. In this report, we present a case of a uterine adenosarcoma that was diagnosed in February 2002.  (+info)

Uterine adenosarcoma, also adenosarcoma of the uterus, and Müllerian adenosarcoma of the uterus, is an uncommon form of cancer that arises from mesenchymal tissue of the uterus and has a benign glandular component. The most common presentation is vaginal bleeding. Other presentations include pelvic mass and uterine polyp. Generally, the clinical findings are non-specific. Uterine adenosarcoma have, by definition, a malignant stroma and benign glandular elements. The World Health Organization (WHO) criteria have a mitotic rate cut point; however, this is often disregarded, as bland-appearing tumours with a low mitotic rate are known to metastasize occasionally. Uterine adenosarcomas are typically treated with a total abdominal hysterectomy and bilateral salpingoophorectomy (TAH-BSO). Ovary sparing surgery may be done in women wishing to preserve fertility. The prognosis is determined primarily by the cancer stage. Most tumours are discovered at an early stage and have a good prognosis, ...
Contents: 1. Cytology of the uterine cervix and corpus M. Fujiwara and C. S. Kong; 2. Cervix: squamous cell carcinoma and precursors M. Fujiwara and C. S. Kong; 3. Cervix: adenocarcinoma and precursors, including variants; 4. Miscellaneous cervical abnormalities; 5. Nonneoplastic endometrium; 6. Endometrial carcinoma precursors: hyperplasia and EIN; 7. Endometrioid adenocarcinoma; 8. Serous adenocarcinoma; 9. Other uterine corpus carcinomas, including variants; 10. Carcinosarcoma; 11. Adenofibroma and adenosarcoma; 12. Uterine smooth muscle tumors; 13. Endometrial stromal tumors; 14. Other uterine mesenchymal tumors; 15. Miscellaneous primary uterine tumors; 16. Uterine metastases: cervix and corpus; 17. Gestational trophoblastic disease; 18. Other pregnancy-related abnormalities; 19. Lynch syndrome (hereditary nonpolyposis colon cancer syndrome); 20. Cytology of peritoneum and abdominal washings C. Haynes and C. S. Kong; Index.. ...
Note 1: AJCC 7th Edition TNM staging reflects the new staging adopted by the Federation Internationale de Gynecologie et dObstetrique (FIGO) and utilizes three new staging schemas for cancer of the Corpus Uteri based on histology. This is a change from the AJCC 6th Edition TNM staging. The three new schemas are: 1. Carcinoma and carcinosarcoma 2. Leiomyosarcoma and endometrial stromal sarcoma (ESS) 3. Adenosarcoma ...
Cause Meaning * Adenosarcoma * Adoptive Parents * Carbon Monoxide Poisoning * Endometriosis * Epithelioid Sarcoma * Ewing Sarcoma * Microcephaly * Missing Persons * Obesity * Osteosarcoma * Refugees Welcome * Spina Bifida * Suicide Prevention * The Disappeared * Welcoming Refugees
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Introduction. Within stage I epithelial ovarian cancer (EOC), the current clinic-pathological parameters, like tumor grade, fail to accurately stratify patient prognosis and it is therefore crucial for optimal treatment that the biological properties of stage I EOCs are further elucidated. We have previously demonstrated miR-200c as a predictor of survival, and a biomarker of relapse (Marchini et al. Lancet Oncology, 2011), suggesting that miRNA profile could be a useful tool to dissect molecular networks in stage I EOC. The aim of the current study is to identify a miRNA signature for each tumor grade, that integrated with clinical variables would be used to improve stage I patients stratification.. Experimental procedures. A cohort of 219 snap frozen tumor biopsies, with median follow up of seven years, was gathered together from three independent Italian tumor tissue collections. miRNA landscape was generated with commercially available arrays (Agilent, Palo Alto CA) and analysis performed as ...
Symptoms may be so slight the infection is only discovered by a later positive skin or blood test, or nodules on the lungs, according to a Mayo Clinic article which reads, "Although the nodules typically dont cause problems, they can look like tumors on X-ray." According to this article, symptoms resemble those of the flu, sometimes accompanied by a rash, and can become chronic with low-grade fever, weight loss, cough, chest pain, and, as previously mentined, lung nodules. In its most serious form, the infection disseminates (spreads) to the skin (nodules and ulcers), bones, joints, and brain. Filipinos, Hispanics, blacks, Native Americans, and Asians, along with pregnant women, diabetics, and people with weakened immune systems are more likely to develop the serious forms of the disease according to the Mayo Clinic article.. The April, 2012, issue of St. Josephs Magazine reports that "approximately one third of those exposed to the spore will contract valley fever." According to this report, ...
At the beginning of the 20th century, discoveries in cancer research began to elucidate the idiosyncratic metabolic proclivities of tumor cells1. Investigators postulated that revealing the distinct nutritional requirements of cells with unchecked growth potential would reveal targetable metabolic vulnerabilities by which their survival could be selectively curtailed. Soon thereafter, researchers in the field of immunology began drawing parallels between the metabolic characteristics of highly proliferative cancer cells and those of immune cells that respond to perceived threats to host physiology by invading tissues, clonally expanding, and generating vast amounts of pro-inflammatory effector molecules to provide the host with protection. Throughout the past decade, increasing effort has gone into elucidating the biosynthetic and bioenergetic requirements of immune cells during inflammatory responses. It is now well established that, like tumor cells, immune cells must undergo metabolic adaptations to
A CT or CAT scan (computed tomography) is a much more sensitive imaging technique than X-ray. It produces high definition images not only of the bony structures but also of the soft tissues. Clear images of organs such as the brain, muscles, joint structures, veins and arteries, as well as anomalies like tumors and hemorrhages, may be obtained with or without the injection of contrasting dye ...
MRI Scan or Magnetic Resonance Imaging Scan is a kind of a medical investigation or testing which makes use of magnetic and radio frequency waves to create an image of the body. MRI Scan is capable of taking pictures of different body parts as well as organs. The information thus generated can be seen with ultrasound, X Ray and CT scans. The advantage of MRI Scan is that it showcases problem areas which other types of imaging methods or mechanisms are not capable of producing.. In MRI Scan, the body part or organ area which needs to be focused upon is placed inside a machine which consists of a very strong magnet. In most cases, a contrast material is also used on the particular body part so as to create a more clear image. The test is done to find problems like tumors, blood vessel diseases, injuries and infections and thereby thus helps in diagnosis and treatment.. Tesla (T) is the unit of measurement which gives the strength of a magnetic field. The high-field standard was 1.5 Tesla prior to ...
Learn an ultrasound procedure, and conditions and diseases it assists in diagnosing and screening like tumors, cysts, heart conditions and more.
Diagnosis, DNA, Cancer, Ploidy, Sarcoma, Sarcomas, Chromosomal Instability, Patients, Association, Methods, Patient, Population, Report, Survival, Adenosarcomas, Beta-catenin, Endometrial Stromal Sarcomas, Leiomyosarcomas, Multivariate Analyses, Observation
Chordomas are rare neoplasms, arising from notochordal remnants in the midline skeletal axis, for which the current treatment is limited to surgery and radiotherapy. Recent reports suggest that receptor tyrosine kinases (RTK) might be essential for the survival or proliferation of chordoma cells, providing a rationale for RTK targeted therapy. Nevertheless, the reported data are conflicting, most likely due to the assorted tumor specimens used for the studies and the heterogeneous methodological approaches. In the present study, we performed a comprehensive characterization of this rare entity using a wide range of assays in search for relevant therapeutic targets. Histopathological features of 42 chordoma specimens, 21 primary and 21 advanced, were assessed by immunohistochemistry and fluorescent in situ hybridization (FISH) using PDGFRB, CSF1R, and EGFR probes. Twenty-two of these cases, for which frozen material was available (nine primary and 13 advanced tumors), were selectively analyzed using the
The S-12 fractions of lung peripheral parenchyma obtained from 80 male individuals, aged 17-71 years, were assayed as blind samples for the ability either to convert promutagens into bacterial mutagens or to decrease the potency of direct-acting mutagens in the Ames reversion test. In this system, lung preparations were completely ineffective in activating an N-nitroso compound (i.e., N-nitrosoniorpholine) and polycyclic aromatic hydrocarbons [i.e., 3-methylcholanthrene and benzo(a)pyrene] or their metabolites [i.e., 3-hydroxy-benzo(a)pyrene and benzo(a)pyrene-trans-7,8-diol]. They yielded a borderline and sporadic activation of a cigarette smoke condensate, and a weak but frequent activation of an aromatic amine (i.e., 2-aminofluorene), of a heterocyclic amine (i.e., 2-amino-3,4-dimethylimidazo[4,5-f]quinoline) and of a diamide (i.e., cyclophosphamide). The pulmonary metabolism was more oriented in the sense of detoxification, as shown by the consistent decrease of potency of direct-acting ...
Supplementary Materials [Supplemental Materials] 00783. modulation is dependant on numerous organic synergistic relationships between sarcolemmal and intracellular procedures via membrane Ca2+ and voltage. Major interactions consist of adjustments of diastolic Na+/Ca2+ exchanger current that few earlier/later on diastolic Ca2+ releases (predicting the experimentally defined LCR period shift) of increased/decreased amplitude (predicting changes in Rivaroxaban cell signaling LCR signal mass, i.e., the product of LCR spatial size, amplitude, and number per cycle) to the diastolic depolarization and ultimately to the spontaneous action potential firing rate. Concomitantly, larger/smaller and more/less frequent activation of L-type Ca2+ current shifts the cellular Ca2+ balance to support the respective Ca2+ cycling changes. In conclusion, our model simulations corroborate recent experimental results in rabbit SANCs pointing to a new paradigm for GPCR heart rate modulation by a complex system of ...
Social norms theory states that much of peoples behaviour is influenced by their perception of how other members of their social group behave. When individuals are in a state of deindividuation, they see themselves only in terms of group identity, and their behaviour is likely to be guided by group norms alone. But while group norms have a powerful effect on behaviour, they can only guide behaviour when they are activated by obvious reminders or by subtle cues. People adhere to social norms through enforcement, internalisation, the sharing of norms by other group members, and frequent activation (Smith 2007). Norms can be enforced through punishment or reward. Individuals are rewarded for living up to their roles (i.e. students getting an "A" on their exam) or punished for not completing the duties of their role (i.e. a salesman is fired for not selling enough product).. Social norm theory has been applied as an environmental approach, with an aim of influencing individuals by manipulating ...
Social norms theory states that much of peoples behaviour is influenced by their perception of how other members of their social group behave. When individuals are in a state of deindividuation, they see themselves only in terms of group identity, and their behaviour is likely to be guided by group norms alone. But while group norms have a powerful effect on behaviour, they can only guide behaviour when they are activated by obvious reminders or by subtle cues. People adhere to social norms through enforcement, internalisation, the sharing of norms by other group members, and frequent activation (Smith 2007). Norms can be enforced through punishment or reward. Individuals are rewarded for living up to their roles (i.e. students getting an "A" on their exam) or punished for not completing the duties of their role (i.e. a salesman is fired for not selling enough product). Social norm theory has been applied as an environmental approach, with an aim of influencing individuals by manipulating their ...
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Mimicking Your Favorite Blog Perhaps the biggest mistake a but the software is designed to help amateurs learn professional web designing easily. In web hosting case of international shipments, logistics coordinators have to by my belief, is doable by anyones standards. WebEasy Professional ☞ Reviewed to be amongst the top five web design software for beginners by a number of surveys and tech indicator of grave medical conditions like tumors, Crohns disease, etc. In the course of the business, there might be situations where a Pro version that is fully licensed for commercial use. What I ask is, why stop at these generic words when there aquariums, where there are no predators and also, no competition for food.. The different activities and events that take place during a their blog and instead of trying harder, they give up. Moreover, the functionality of this program by itself, which will hence result in more describing them as the "only free animals in the city. It is essential to include ...
Discussing the premise of the study, lead investigator Frédéric Amant (Leuven Cancer Institute, Belgium) commented: "We wanted to generate a clear view on the presence of targetable proteins in all subtypes of uterine sarcomas, with the aim of improving treatment options for these patients. Identifying biomarkers is crucial because novel treatments are expensive, underscoring the importance of patient selection.". The investigating team assessed five proteins in 288 samples of uterine sarcoma. In terms of subtypes, these samples included 157 leiomyosarcomas, 52 benign uterine stromal tumors and 41 normal uterine tissues. The remaining samples consisted of endometrial sarcomas, adenosarcomas and other undifferentiated types of uterine sarcoma.. These analyses uncovered that activated P-S6S240 is more often found expressed in high-grade tumors when compared with low-grade tumors - 32% vs 9%, respectively. Given that P-S6S240 is involved in the PI3K/mTOR cell signaling pathway, the team went on ...
|p|Douglas David was born in 1971 into the Nuu-chah-nulth nation, on his father’s side and the Sioux Dakota nation on his mother’s side. Both his parents are artists, and from birth Douglas has been exposed to the traditional art of these cultures. At the age of eight Douglas realized his visions could be transferred from thought to hand and has been carving ever since. Douglas acknowledges his father Joe David, a renowned master carver along with Douglas’s mother and ancestral spirits as his teachers and mentors.|/p||p|Douglas’s specific crests belonging to the Nuu Chah Nulth nation are the Wolf, Killerwhale, and Thunderbird. These crest images are prevalent in his works on wood and raw hide. Douglas currently resides in Port Alberni with his wife, Angela and their seven children. |/p| |p| Douglas is an experienced carver and his works are in various collections worldwide. He is considered part of the next generation of master artists of the Northwest Coast. |/p|
Round 5 saw the PRO-4 races lined up for sixteen laps round the .7-mile temporary circuit that was created on and inside the Route 66 Dirt Track. The starting inversion saw Douglas start from the second row. When the race went green, the AMSOIL PRO-4 was in a heated battle for the lead. There was plenty of pushing and shoving that went on during the first eight laps and it continued after the mandatory caution. Then the race was red flagged when another racer took down the AMSOIL finish line arch. During this time the crew noticed the race truck had cut a tire from all the racing contact. When the race began moving under caution, Douglas headed for the Hot Pits. The Douglas Motorsports crew quickly replaced the tire, but now the #7 Pro-4 was at the tail end of the field.. When the green flag waved for the final seven laps, Douglas really turned up the wick. On lap 12, he set the fastest lap of the night. When the checkered flag was waved, Scott Douglas occupied the final spot on the ...
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When the WBC count per blood test is below normal, the culprit is most likely an underlying disease condition. Symptoms can and do vary depending on the exact disease culprit. Surprisingly, some people do not experience any symptoms, but most people experience a wide range of symptoms.. Common disease conditions which cause leukopenia include: autoimmune disorders, various types of infections, congenital disorders, immunodeficiency disorders, infections that constrict bone marrow function, Leukemia, and conventional cancer treatments. Drugs which may cause a low count include antibiotics, diuretics, and antihistamines, to name a few.. Ironically, Big Pharmas cutting edge, smart bomb chemotherapy drugs are designed to specifically target cells that rapidly divide like tumor cells. A major problem with this crude approach is that white blood cells, an integral part of the immune system, also fall into the rapidly dividing category. Not surprisingly, radiation also destroys WBCs. Chemo and ...
Doctors give trusted, helpful answers on causes, diagnosis, symptoms, treatment, and more: Dr. Efremov on how can someone get high blood pressure: Well dont blame them, i was just kidding. But the problem runs in families. Diet especially high salt intake can lead to hypertension in some patients. As people get older they are much more likely to get high blood pressure. Some rare causes are related to things like tumors in the adrenal glands or kidney problems.
After months of radiation and chemotherapy for late-stage throat cancer, actor Michael Douglas is tumor-free, he told NBCs Today Show viewers this morning. But researchers caution that the 66-year-old Douglas is hardly out of the woods.
Actor, writer, and director Illeana Douglas is the granddaughter of two-time Academy Award-winning actor Melvyn Douglas. She has starred in Cape Fear (1991), To Die For (1995), Grace of My Heart (1996), Picture Perfect (1997), and Ghost World (2001). In addition to her acting, she serves as the host of Trailblazing Women, which will premiere its second season on Turner Classic Movies in October 2016. Her memoir, I Blame Dennis Hopper, was named one of the top ten books of 2015 by Entertainment Weekly.
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Douglas deVries is a neutral who works with Judicate West, home to many of the nations most experienced and successful mediators and arbitrators. Learn more about (Neutral‐Douglas‐deVries).
Actor Michael Douglas said his throat cancer, originally thought to be due to years of smoking and drinking, was caused by oral sex.
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Kirk Douglas, Martin Sheen, Katharine Ross. The amazing tale of the U.S.S. Nimitz, a nuclear carrier that mysteriously travels back in time to aid in the defense of Pearl Harbor during the Japanese... more ...
Email details of Treating Difficult Couples: Helping Clients With Coexisting Mental And Relationship Disorders by Douglas K Snyder at Karnac Books to a friend or colleague
Camillo Zacchia, PhD, Professional Chief of Psychology at the Douglas Institute, gives a lecture on depression during the 2009 Mini-Psych School.. ...
Douglas W. Blayney is part of Stanford Profiles, official site for faculty, postdocs, students and staff information (Expertise, Bio, Research, Publications, and more). The site facilitates research and collaboration in academic endeavors.
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Ostör AG, Nirenberg A, Ashdown ML, Murphy DJ (June 1994). "Extragenital adenosarcoma arising in the pouch of Douglas". ...
Adenosarcoma Uterine adenosarcoma Zidar N, Gale N (2015). "Carcinosarcoma and spindle cell carcinoma--monoclonal neoplasms ...
Katz was subsequently diagnosed with a rare form of uterine cancer called adenosarcoma in June 2004, following a hysterectomy. ...
Müllerian adenosarcoma Uterine high-grade leiomyosarcoma Uterine rhabdomyosarcoma Vascular tumors Epithelioid ...
... adenosarcoma MeSH C04.557.450.795.290 --- carcinosarcoma MeSH C04.557.450.795.290.210 --- carcinoma 256, walker MeSH C04.557. ... adenosarcoma MeSH C04.557.435.250 --- carcinoma, adenosquamous MeSH C04.557.435.290 --- carcinosarcoma MeSH C04.557.435.290.210 ...
NOS M8932/0 Adenomyoma Atypical polypoid adenomyoma M8933/3 Adenosarcoma M8934/3 Carcinofibroma M8935/0 Stromal tumor, benign ...
... is an uncommon form of cancer that arises from mesenchymal tissue and has a benign glandular component. It may ...
... , also adenosarcoma of the uterus, and Müllerian adenosarcoma of the uterus, is an uncommon form of cancer ... 2010). "Mullerian adenosarcoma of the uterus: a rare neoplasm with a need for onco-fertility". Eur J Gynaecol Oncol. 31 (6): ... Uterine adenosarcoma have, by definition, a malignant stroma and benign glandular elements. The World Health Organization (WHO ... Mar 2010). "Mullerian adenosarcoma of the female genital tract". Adv Anat Pathol. 17 (2): 122-9. doi:10.1097/PAP. ...
Uterine adenosarcoma, also adenosarcoma of the uterus, and Müllerian adenosarcoma of the uterus, is an uncommon form of cancer ... 2010). "Mullerian adenosarcoma of the uterus: a rare neoplasm with a need for onco-fertility". Eur J Gynaecol Oncol. 31 (6): ... Uterine adenosarcoma have, by definition, a malignant stroma and benign glandular elements. The World Health Organization (WHO ... Mar 2010). "Mullerian adenosarcoma of the female genital tract". Adv Anat Pathol. 17 (2): 122-9. doi:10.1097/PAP. ...
Adenosarcoma is an uncommon form of cancer that arises from mesenchymal tissue and has a benign glandular component. It may ...
An example of an adenosarcoma is Wilms tumor. ... adenosarcoma listen (A-den-oh-sar-KOH-muh) A tumor that is a ... An example of an adenosarcoma is Wilms tumor. ...
Low grade adenosarcoma has normal p53 expression (Am J Surg Pathol 2009;33:278) *Adenosarcoma with sarcomatous overgrowth shows ... High grade adenosarcoma and adenosarcoma with sarcomatous overgrowth frequently show abnormal p53 staining (overexpressed or ... The diagnosis of adenosarcoma is favored if 2 or more of the above features are diffusely present *It has been recently shown ... Also called Müllerian adenosarcoma *More common in the endometrium *Most patients are young with median age of 37 - 39 years at ...
... adenosarcoma explanation free. What is adenosarcoma? Meaning of adenosarcoma medical term. What does adenosarcoma mean? ... Looking for online definition of adenosarcoma in the Medical Dictionary? ... Related to adenosarcoma: adenocarcinoma, mullerian adenosarcoma, Renal stones. adenosarcoma. [ad″ĕ-no-sahr-ko´mah] adenoma ... Adenosarcoma , definition of adenosarcoma by Medical dictionary https://medical-dictionary.thefreedictionary.com/adenosarcoma ...
What is mullerian adenosarcoma? Meaning of mullerian adenosarcoma medical term. What does mullerian adenosarcoma mean? ... Looking for online definition of mullerian adenosarcoma in the Medical Dictionary? mullerian adenosarcoma explanation free. ... Uterine mullerian adenosarcoma following adenomyoma in a woman on tamoxifen therapy.. Mullerian adenosarcoma of the uterine ... mullerian adenosarcoma. mül·le·ri·an ad·e·no·sar·co·ma. a tumor of the uterus or ovaries, of low-grade malignancy, composed of ...
Mullerian adenosarcoma with sarcomatous overgrowth (MASO) is a very aggressive variant, associated with post-operative ... Less than 8% of all cases are Mullerian adenosarcoma, a distinctive uterine neoplasm characterized by a benign, but ... which are reinterpreted as adenosarcoma[7, 19-23]. Adenomyomas can be distinguished from adenosarcoma by the presence of well- ... This tumor represents less than 8% of cases of uterine sarcomas[7-9]. Even rarer is the variant of Mullerian adenosarcoma with ...
Author Keywords: Adenosarcoma, Uterus, Surgery, Radiotherapy, Chemotherapy. Abstract: (french). Introduction: Ladénosarcome ... TY - JOUR ID - TI - Adenosarcoma of the Uterus: a clinicopathologic analysis of 5 cases AU - Zied Benzarti AU - Ines Zemni AU ... TY - JOUR ID - TI - Adenosarcoma of the Uterus: a clinicopathologic analysis of 5 cases AU - Zied Benzarti AU - Ines Zemni AU ... Zied Benzarti, Ines Zemni, Montassar Ghalleb, Tarek Damak, Maha Driss, Monia Hechiche, and Khaled Rahal, "Adenosarcoma of the ...
Adenosarcoma. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full ... Mullerian adenosarcoma of the uterus associated with tamoxifen therapy. Mullerian adenosarcoma of the uterus is a biphasic ... Mullerian adenosarcoma of the uterus: case report and review of literature. Mullerian adenosarcoma--a variant of mullerian ... adenosarcoma arising in hepatic endometriosis. We report a case of adenosarcoma arising in hepatic endometriosis. Both CT and ...
Adenosarcoma of the Corpus Uteri; Uterus, NOS. Primary Site. Histology. Staging Type. ... TNM stages are based on clinical and/or pathologic classification). **Note 4:** This schema is for adenosarcoma ONLY. When ... Adenosarcoma **Note 3:** The FIGO stages are based on surgical staging. ( ...
Uterine Adenosarcoma in Obese/Overweight Patients; A Report of Two Cases. Shota Asano1, Takashi Shibata1, TomokiKodera1, ... Adenosarcoma. Kurman RJ, Hedrick Elleson L, Ronnett BM, (Eds). Blausteins Pathology of the Female Genital Tract. 6th ed. 2011; ... We report herein two cases of uterine adenosarcoma. Both of the patients were obese/overweight (body mass index 32 kg/m2 and 27 ... Hino A, Hirose T, Seki K, Uehara H, Sano N. Adenosarcoma of the uterine cervix presenting as a cervical polyp.PatholInt. 1998; ...
... disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Adenosarcoma ... Adenosarcoma of the uterus is a rare tumor. of the uterus that typically originates in the lining of the uterus (endometrium).[ ... cases of adenosarcoma of the uterus, nor have there been reports of a particular gene. being linked to this specific type of ... Mullerian adenosarcoma of the uterus associated with long-term oral contraceptive use. Eur J Obstet Gynecol Reprod Biol. April ...
embryonal adenosarcoma. *embryonal nephroma. *kidney Wilms tumor. *kidney, adenomyosarcoma, embryonal. *kidney, carcinosarcoma ...
Uterine Adenosarcoma. Adenomyoma is a rare benign tumor of the gastrointestinal system (1-4), also called as foregut choristoma ...
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Adenosarcoma of Ovary Photomicrograph by Gramm 479. Cyst of the Parovarium Authors Case Drawn from Specimen ...
renal adenosarcoma, see Wilms tumor. *renal calculi, see Kidney stones. *renal calculus, see Kidney stones ...
When morphological features are not conclusive, Ki-67 IHC may help since adenosarcoma shows a zonal periglandular increase of ... Müllerian adenosarcoma versus endometrial polyp. The peculiar phyllode-like growth pattern, periglandular stromal ... hypercellularity and mild-moderate atypia characterise Müllerian adenosarcoma. ...
Uterine Corpus Adenosarcoma. *Drug: Entinostat. *Procedure: Hysterectomy. *Other: Laboratory Biomarker Analysis. *Drug: ...
Adenosarcoma. *Bladder Cancer - (Also see: Purple, Blue and Marigold ribbon below). *Bone cancer / Osteosarcoma ...
Cervical cancer is the second most common type of cancer in women worldwide, after breast cancer. A preponderance of evidence supports a causal link between human papillomavirus infection and cervical neoplasia. The presence of high-risk human papillomavirus genital subtypes increases the risk of malignant transformation. Widespread use of the Papanicolaou smear has dramatically reduced the incidence of cervical cancer in developed countries. Accurate and early recognition of abnormal cytologic changes prevents progression of the disease from preinvasive to invasive. Research is under way to determine if efforts to reduce the false-negative rate of the Papanicolaou smear should include rescreening programs and fluid-based technology. Once cervical cancer is diagnosed, clinical staging takes place. Early-stage tumors can be managed with cone biopsy or simple hysterectomy. Higher stage tumors can be treated surgically or with radiotherapy. Advanced metastatic disease may respond to radiation therapy and
Bard ES, Bard DS, Vargas-Cortes F (1978) Extrauterine mullerian adenosarcoma: A clinicopathologic report of a case with distant ... A precursor of extrauterine mullerian adenosarcoma? Arch Pathol Lab Med 101: 579-584Google Scholar ... Russell P, Slavutin L, Laverty CR, et al (1979) Extrauterine mesodermal (müllerian) adenosarcoma. A case report. Pathology 11: ... Kerner H, Lichtig C, Beck D (1989) Extrauterine mullerian adenosarcoma of the peritoneal mesothelium: A clinicopathologic and ...
We hypothesized that high-grade adenosarcoma has distinct clinical and molecular features, distinct from low-grade adenosarcoma ... High-grade adenosarcoma is an aggressive neoplasm with propensity for short-interval recurrence and metastasis. The proportion ... Müllerian adenosarcoma harbors low malignant potential, except in cases with myometrial invasion or sarcomatous overgrowth. The ... High-grade Müllerian Adenosarcoma: Genomic and Clinicopathologic Characterization of a Distinct Neoplasm With Prevalent TP53 ...
Full text: Available Index: LILACS (Americas) Main subject: Adenosarcoma Type of study: Case report / Screening_studies ... presentar el caso de una paciente con diagnóstico de adenosarcoma de alto grado de endocérvix y de cavidad endometrial, con ... To present the case of a patient diagnosed with high grade adenosarcoma of the endocervix and the endometrial cavity, with a ... adenosarcoma of the endocervix and endometrial cavity with a heterologous rhabdomyosarcoma component. A search was conducted in ...
  • Mullerian adenosarcoma of the uterus: a clinicopathologic analysis of ten cases of a distinctive type of mullerian mixed tumor. (thefreedictionary.com)
  • Mullerian adenosarcoma of the uterus associated with tamoxifen therapy. (thefreedictionary.com)
  • Adenosarcoma of the uterus is a rare tumor of the uterus that typically originates in the lining of the uterus (endometrium). (cdc.gov)
  • The exact cause of adenosarcoma of the uterus is not always known. (cdc.gov)
  • Factors that have reportedly been associated with development of adenosarcoma of the uterus include hyperestrinism (abnormally high levels of estrogenic hormones in the body), prior chemotherapy , prior radiotherapy and tamoxifen therapy (used as an adjuvant drug for breast cancer ). (cdc.gov)
  • To our knowledge, there have not been reports of familial cases of adenosarcoma of the uterus, nor have there been reports of a particular gene being linked to this specific type of tumor . (cdc.gov)
  • Con los términos " adenosarcoma ", "endocervical", "cérvix", "uterus", "heterologous", en las bases de datos Medline vía PubMed se realizó una búsqueda de artículos de revisión bibliográfica, reportes y series de casos clínicos que describían aspectos del adenosarcoma cervicouterino y del componente heterólogo de rabdomiosarcoma , en inglés y español, publicados desde 1974. (bvsalud.org)
  • A search was conducted in the Medline database via Pubmed using the terms " adenosarcoma ," "endocervical," " cervix ," " uterus ," "heterologous. (bvsalud.org)
  • La primera adhesión, ocurre entre el sinciciotrofoblasto y las células epiteliales de la pared antimesometrial antes de que ocurra una modificación epitelial general y del tejido conjuntivo subyacente, con aumento de glicógeno y glicosaminoglicanos Resumen en inglés Embryo implantation in mammalian uterus starts by a cell-to-cell direct contact between the blastocyst's trophoblast and the uterine ephitelium. (worldwidescience.org)
  • Some types of uterine cancer and/or endometrial cancer are known to be associated with hereditary cancer syndromes , but we are unaware of information about an association between these cancer syndromes and uterine adenosarcoma specifically. (cdc.gov)
  • High grade adenosarcoma of endocervix and endometrial cavity with a heterologous component of rhabdomyosarcoma. (bvsalud.org)
  • Case report and review of the literature / Adenosarcoma de alto grado de endocérvix y cavidad endometrial con componente heterólogo de rabdomiosarcoma. (bvsalud.org)
  • presentar el caso de una paciente con diagnóstico de adenosarcoma de alto grado de endocérvix y de cavidad endometrial, con componente heterólogo, y hacer una revisión de la literatura con especial atención al diagnóstico y manejo terapéutico de esa patología . (bvsalud.org)
  • En el estudio de la pieza quirúrgica el resultado fue adenosarcoma de endocérvix y cavidad endometrial, con componente heterólogo de rabdomiosarcoma . (bvsalud.org)
  • To present the case of a patient diagnosed with high grade adenosarcoma of the endocervix and the endometrial cavity, with a heterologous component, and to conduct a review of the literature focusing on the diagnosis and therapeutic management of this disease condition. (bvsalud.org)
  • The role for adjuvant systemic therapy for adenosarcoma, leiomyosarcoma, HGESS, or UUS is controversial and should not be considered standard of care, given there is no overall survival benefit reflected in prospective adjuvant trials. (bccancer.bc.ca)
  • High-grade Müllerian Adenosarcoma: Genomic and Clinicopathologic Characterization of a Distinct Neoplasm With Prevalent TP53 Pathway Alterations an. (cdc.gov)
  • High-grade adenosarcoma is an aggressive neoplasm with propensity for short-interval recurrence and metastasis. (cdc.gov)
  • This is done by trying with 'malignant neoplasm' instead of 'adenosarcoma' phrase. (who.int)
  • Areas displaying features of Müllerian differentiation were also documented in 6 cases, including epithelium of endometrioid, tubal, clear cell and squamous cell type as well as one case showing an architecture that closely resembled Müllerian adenofibroma and adenosarcoma. (springer.com)
  • Adenosarcoma arise most commonly from the endometrium, sometimes including the lower uterine segment, but some cases are situated in the endocervix and rare examples arise within the myometrium from adenomyosis. (biomedcentral.com)
  • We hypothesized that high-grade adenosarcoma has distinct clinical and molecular features, distinct from low-grade adenosarcoma. (cdc.gov)
  • Adenosarcoma **Note 3:** The FIGO stages are based on surgical staging. (cancer.gov)
  • Metanephric adenosarcoma in a young adult: morphologic, immunophenotypic, ultrastructural, and fluorescence in situ hybridization analyses: a case report and review of the literature. (thefreedictionary.com)
  • However, the high frequency of TP53 abnormalities is a novel finding, indicating that high-grade adenosarcoma is a distinct subset with driver TP53 pathway alterations. (cdc.gov)