(1/28) Mullerian tumor (atypical polypoid adenomyoma) with sex-cord differentiation arising from the oviduct in an adolescent cynomolgus monkey (Macaca fascicularis).

In a 6.5-year-old cynomolgus monkey (Macaca fascicularis), a tumor mass was macroscopically located near the right ovary, connected to the oviduct, and completely separated from the uterus. The mass was an elongated spherical shape with a smooth surface and milky-white color. It was approximately 3.5 cm across its major axis, and the sagittal section was composed of cystic walls and a multi-lobular luminal nodule. Light-microscopically, the polypoid mass consisted of admixtures of neoplastic mesenchymal and epithelial elements. Lipid-rich foamy cells scattered within the tumor mass formed nest-like/aggregated populations. Immunohistochemically, mesenchymal tumor cells stained diffusely positive for vimentin, desmin, and alpha (alpha)-smooth muscle actin, demonstrating a smooth muscle origin. Mesenchymal tumor cells contained mitotic figures, and tumor elements including mesenchymal, epithelial, and lipid-rich foamy cells stained strongly positive for proliferating cell nuclear antigen (PCNA). Moreover, lipid-rich foamy cells elicited positive reactions for testosterone, suggesting sex-cord element differentiation. Electron-microscopically, actin filaments, basement membranes, and electron-dense cytoplasmic bodies were noted in the spindle cells, and invaginated nuclei were observed in adenomatous cells. In contrast, foamy cells contained numerous lipid vacuoles in the cytoplasm. From these findings, the tumor was diagnosed as an atypical polypoid adenomyoma (benign mixed mullerian tumor) with sex-cord differentiation arising from the oviduct. This tumor was considered to be an exceedingly rare finding in the adolescent cynomolgus monkey.  (+info)

(2/28) Adenomyoma and adenomyomatous hyperplasia of the Vaterian system: clinical, pathological, and new immunohistochemical features of 13 cases.

Adenomyoma and adenomyomatous hyperplasia of the Vaterian system are consistently benign lesions. Clinically, adenomyoma mimics frequently ampullary adenoma or carcinoma, and biopsy analysis is often difficult. The histogenesis of ampullary adenomyoma and adenomyomatous hyperplasia is still subject to debate. We present a retrospective study of clinicopathological features of 13 cases of surgically resected ampullary adenomyoma. The age of our patients was between 38 and 78 years (mean: 63 y). The preoperative diagnosis was ampullary tumor or tumor of the head of the pancreas. On macroscopy, a white, firm lesion of the ampullary wall was observed; its size ranged between 10 and 30 mm. Histologically the lesion consisted of multiple glandular structures surrounded by a fibroblastic/myofibroblastic proliferation, resulting in a "pseudo-hypertrophy" of the Vaterian system. The immunophenotype of the epithelial component was cytokeratin 7+/cytokeratin 20-, similar to that of the normal biliary and pancreatic duct system. The epithelial cells exhibited low proliferative activity. The hyperplastic myofibroblastic cells expressed smooth muscle actin. A complete pancreatic heterotopy contiguous with the adenomyoma was noted in three cases. Adenomyoma and adenomyomatous hyperplasia of the Vaterian system are benign lesions frequently treated by extensive surgery because of long-term biliary obstruction. The clinicopathological characteristics suggest either a reactive and/or a malformative, nonneoplastic nature for this lesion, which could, in some cases, develop from heterotopic pancreas. The immunophenotype of epithelial cells may be a useful tool for differentiating it from ampullary adenoma on biopsy specimens.  (+info)

(3/28) Collagenous spherulosis in an adenomyoepithelioma of the breast.

Collagenous spherulosis (CS) is an incidental finding that usually occurs in association with benign proliferative and preinvasive lesions. Adenomyoepithelioma is a biphasic neoplasm of the breast, composed of both luminal epithelial and myoepithelial cells. Despite the common epimyoepithelial histogenesis, CS has never been described in association with adenomyoepithelioma. This report describes the case of a 48 year old woman who presented with CS of the breast in an adenomyoepithelioma. The combination of these two benign lesions led to diagnostic difficulties; namely, differentiation from adenoid cystic carcinoma, but also cribriform carcinoma and cylindroma of the breast. Antibodies to the oestrogen receptor, progesterone receptor, p63, and c-kit (CD117) proved to be useful adjuncts to differentiate between these lesions.  (+info)

(4/28) Adenomyoma of the small intestine in children: a rare cause of intussusception: a case report.

Adenomyomas are hamartomas of the alimentary tract with exceptionally rare localization at the ileum. The case presented here concerns an infant aged 18 months suffering from adenomyoma of the ileum, which was responsible for the development of ileoileac intussusception. Our paper aims at underlining the particularities of this extremely rare entity, while adding the 13th case reported to the international bibliographic references.  (+info)

(5/28) Adenocarcinoma arising in gastric heterotopic pancreas: a case report.

A heterotopic pancreas in the gastrointestinal tract is mostly found incidentally and its malignant transformation is extremely rare. We describe the second case of adenocarcinoma arising in a gastric heterotopic pancreas of an asymptomatic 35-yr-old man in Korea. Esophagogastroduodenoscopy revealed a submucosal tumor with an irregular central umbilication in the gastric antrum. A wedge resection specimen demonstrated a submucosal oligolocular cystic mass (1.7 x 1.4 x 1.2 cm) with a solid portion. Microscopically, the cystic portion was composed of dilated pancreaticobiliary type ducts with adjacent small foci of periductal glandular structures. The adenocarcinoma components in the solid area infiltrated the proper muscle and the overlying mucosa of the stomach. The transitional area between the benign ductal structures and the adenocarcinoma component was found. The follow-up course was uneventful 5 months postoperatively.  (+info)

(6/28) Polypoid adenomyomas: sonohysterographic and color Doppler findings with histopathologic correlation.

OBJECTIVE: This study was undertaken to describe the sonographic features of polypoid adenomyomas of the uterus and to determine the diagnostic role of sonohysterography and color Doppler sonography in the evaluation of these lesions. METHODS: The sonographic findings for 46 histologically proved cases of polypoid adenomyomas of the uterus, accumulated over 10 years, were reviewed retrospectively. The pathologic diagnoses included typical polypoid adenomyoma (n = 36), atypical polypoid adenomyoma (n = 7), and low-grade adenosarcoma arising in polypoid adenomyoma (n = 3). RESULTS: Of 46 total uterine tumors, 31 were in the corpus, 12 were in the fundus, and 3 were in the isthmus. The mean tumor size was 3.5 cm (range, 0.5-9 cm). The tumors were polypoid in 30 cases, pedunculated in 11 cases, and sessile in the remaining 5 cases. Of the pedunculated tumors, 5 protruded into the endocervical canal and 2 had prolapsed into the vagina. Three distinct sonographic patterns were identified with respect to the presence of cystic areas: a solid mass (pattern 1) in 12 cases, a solid mass with cystic areas (pattern 2) in 32 cases, and a predominantly cystic mass (pattern 3) in 2 cases. The characteristic sonographic features of polypoid adenomyomas included heterogeneous or homogeneous isoechogenicity relative to the myometrium, a smooth surface, a poorly defined margin with the underlying myometrium, hemorrhagic foci, posterior shadowing, a single vascular pedicle entering the mass, and associated adenomyosis in the myometrium. CONCLUSIONS: Knowledge of the sonographic appearance of polypoid adenomyomas may facilitate diagnosis and may help distinguish these tumors from other polypoid uterine tumors.  (+info)

(7/28) Adenomyomatosis with marked subserosal fibrosis and lipomatosis of the gallbladder: mural stratification demonstrated with MR.

The authors reported a case of fundal-type adenomyomatosis in which mural stratification corresponding to histopathological findings was clearly demonstrated with MR imaging. Single-shot fast spin echo images for MR cholangiopancreatography clearly visualized Rokitansky-Aschoff sinuses (RAS), which are a diagnostic clue for this disease. However, mural stratification comprising RAS with muscular proliferation, massive fibrosis and subserosal fat deposition was more precisely demonstrated in T(2)-weighted images obtained with fast spin echo.  (+info)

(8/28) Progesterone-dependent release of transforming growth factor-beta1 from epithelial cells enhances the endometrial decidualization by turning on the Smad signalling in stromal cells.

Endometrial decidualization results from the differentiation of stromal cells in an ovarian steroid-sensitive manner. Human endometrial tissues obtained from fertile women at various stages of the menstrual cycle were subjected to immunohistochemistry to localize the components of the transforming growth factor-beta (TGF-beta) system. TGF-beta receptor-I and -II expression was higher in stromal cells than in epithelial cells during the secretory phase while no such variation was observed during the proliferative phase. The expression of phosphorylated Smad3 (pSmad2/3), an activated form of a component of the TGF-beta signalling pathway, and translocation of pSmad2/3 from the cytoplasm to the nucleus were more pronounced in secretory endometrium. In coculture of human endometrial epithelial with stromal cells, each isolated from the proliferative endometrium, administration of progesterone stimulated decidualization as well as TGF-beta signalling activation in stromal cells. Progesterone also significantly elevated the concentration of TGF-beta1 in the coculture medium. Careful manipulation of the coculture, i.e. selective addition and omission of the cellular components, showed that this progesterone-induced increase in secretion of TGF-beta1 come mainly from epithelial cells. Moreover, administration of TGF-beta1 (10 ng/ml) directly to cultured stromal cells enhanced the expression of prolactin as well as pSamd2/3 even without progesterone. Taken together, our present data support the notion that progesterone induces stromal decidualization indirectly, i.e. by enhancing the expression and secretion of TGF-beta1 from epithelial cells. The secreted, epithelial-derived TGF-beta1 then acts on adjacent stromal cells, at least in part, to turn on Smad signalling that could lead to stromal decidualization.  (+info)

*  Adenomyoma
Atypical polypoid adenomyoma Adenomyosis "adenomyoma" at Dorland's Medical Dictionary Takeuchi H, Kitade M, Kikuchi I, Kumakiri ... Adenomyoma is a tumor (-oma) including components derived from glands (adeno-) and muscle (-my-). It is a type of complex and ... In the case of juvenile cystic adenomyoma, laparoscopic enucleation results in a statistically and clinically significant ... and histopathologic findings of juvenile cystic adenomyoma: a review of nine cases". Fertil. Steril. 94 (3): 862-868. doi: ...
*  Atypical polypoid adenomyoma
... , abbreviated APA, is a rare uncommon benign tumour of the uterus. APAs are characterized by glands ... Adenomyoma Cervical cancer Intermed. mag. Very high mag. Jakus, S.; Edmonds, P.; Dunton, C.; Holland, G. (Jan 2002). "Atypical ... polypoid adenomyoma mimicking cervical adenocarcinoma". J Low Genit Tract Dis. 6 (1): 33-8. doi:10.1046/j.1526-0976.2002.61007. ...
*  Uterus-like mass
Khurana A, Mehta A, Sardana M (2011). Extrauterine adenomyoma with uterus-like features. A rare entity presenting 17 years post ... Redman R, Wilkinson EJ, Massoll NA (2005). Uterine-like mass with features of an extrauterine adenomyoma presenting 22 years ...
*  Adenomyosis
Adenomyoma Atypical polypoid adenomyoma "adenomyosis" at Dorland's Medical Dictionary Lazzeri L, Di Giovanni A, Exacoustos C et ... Myometrium or adenomyoma resection: In this procedure, surgeons remove a focal consolidation of adenomyosis known as an ... Adenomyosis may involve the uterus focally, creating an adenomyoma. With diffuse involvement, the uterus becomes bulky and ... adenomyoma. To be successful this procedure requires that the adenomyosis is relatively focally isolated and with a minimal ...
*  Polypoid
They include: Polypoid melanoma Atypical polypoid adenomyoma Polypoid basal-cell carcinoma. ...
*  Squamous metaplasia
... atypical polypoid adenomyoma), chronic irritation or cancer (e.g. endometrioid endometrial carcinoma). Metaplasia Dysplasia ...
*  List of MeSH codes (C04)
... adenomyoma MeSH C04.557.435.135 --- adenosarcoma MeSH C04.557.435.250 --- carcinoma, adenosquamous MeSH C04.557.435.290 --- ...
*  Thomas Stephen Cullen
He wrote alone, and in collaboration, four important monographs: Cancer of the Uterus (1900) Adenomyoma of the Uterus (1908) ...
*  International Classification of Diseases for Oncology
NOS M8932/0 Adenomyoma Atypical polypoid adenomyoma M8933/3 Adenosarcoma M8934/3 Carcinofibroma M8935/0 Stromal tumor, benign ...
Atypical polypoid adenomyoma: Retrospective study about 8 cases from Jeanne-de-Flandre Hospital between 1996 and 2008.  Atypical polypoid adenomyoma: Retrospective study about 8 cases from Jeanne-de-Flandre Hospital between 1996 and 2008.
To propose a therapeutic approach and follow-up of patients with atypical polypoid adenomyoma (APA) wishing to remain fertile. ... OBJECTIVES: To propose a therapeutic approach and follow-up of patients with atypical polypoid adenomyoma (APA) wishing to ...
more infohttp://www.biomedsearch.com/nih/Atypical-polypoid-adenomyoma-Retrospective-study/22306097.html
Adenomyoma | OGH Reports  Adenomyoma | OGH Reports
Gastric Adenomyoma Causing Outlet Obstruction. Submitted by sysadmin1 on Tue, 05/10/2016 - 16:04 ... Gastric Adenomyoma Causing Outlet Obstruction. Oncology, Gastroenterology and Hepatology Reports. 2016;5(1):45-47. ...
more infohttp://www.oghreports.org/tags/adenomyoma
Laparoscopic treatment of a large uterine cystic adenomyosis in a young patient -- Koukoura et al. 2015 -- BMJ Case Reports  Laparoscopic treatment of a large uterine cystic adenomyosis in a young patient -- Koukoura et al. 2015 -- BMJ Case Reports
Juvenile cystic adenomyoma in a 19-year-old woman: a case report with a proposal for new diagnostic criteria. J Laparoendosc ... Laparoscopic management of juvenile cystic adenomyoma: four cases. J Minim Invasive Gynecol 2011;18:343-8. doi:10.1016/j.jmig. ... Diagnosis, laparoscopic management, and histopathologic findings of juvenile cystic adenomyoma: a review of nine cases. Fertil ... 2 Adult cystic adenomyoma is usually found in older patients and most often in those over the age of 30. Acién et al3 recently ...
more infohttp://casereports.bmj.com/content/2015/bcr-2015-210358.full
Medical Archives - Personal Paper Collections: The Thomas S. Cullen Collection  Medical Archives - Personal Paper Collections: The Thomas S. Cullen Collection
His research focused on cancer of the uterus, adenomyoma of the uterus, hyperplasia of the endometrium, diseases of the ...
more infohttp://www.medicalarchives.jhmi.edu/papers/cullen.html
Adenomyoma - Wikipedia  Adenomyoma - Wikipedia
Adenomyoma is a tumor (-oma) including components derived from glands (adeno-) and muscle (-my-).[1] It is a type of complex ... "adenomyoma" at Dorland's Medical Dictionary *^ Takeuchi H, Kitade M, Kikuchi I, Kumakiri J, Kuroda K, Jinushi M (June 2009). " ... Uterine adenomyoma[edit]. In obstetrics and gynecology contexts, it is a form of adenomyosis that forms a mass or growth around ... "Adenomyoma" - news · newspapers · books · scholar · JSTOR (December 2009) (Learn how and when to remove this template message ...
more infohttps://en.wikipedia.org/wiki/Adenomyoma
Adenomyoma - definition of adenomyoma by The Free Dictionary  Adenomyoma - definition of adenomyoma by The Free Dictionary
adenomyoma synonyms, adenomyoma pronunciation, adenomyoma translation, English dictionary definition of adenomyoma. adenomyoma ... adenomyoma. Also found in: Medical, Encyclopedia, Wikipedia.. Related to adenomyoma: adenomyosis, endometriosis, ... Adenomyoma - definition of adenomyoma by The Free Dictionary https://www.thefreedictionary.com/adenomyoma ... adenomyoma (benign), endometrial polyps with unusual features, and atypical polypoid adenomyoma.. Uterine Adenosarcoma ...
more infohttp://www.thefreedictionary.com/adenomyoma
Document - Gastric adenomyoma causing outlet obstruction  Document - Gastric adenomyoma causing outlet obstruction
"Gastric adenomyoma causing outlet obstruction." Oncology, Gastroenterology and Hepatology Reports, vol. 5, no. 1, 2016, p. 45. ... Augustine Adenomyoma of stomach is a rare condition that may or may not present with symptoms, often depending on the location ... Introduction Adenomyoma or myoepithelial hamartoma is a lesion with mainly two components-glandular or ductal structures and ... Here, we present a case of gastric adenomyoma with pancreatic heterotopia in the pyloric region causing outlet obstruction. ...
more infohttp://go.galegroup.com/ps/anonymous?p=AONE&sw=w&issn=&v=2.1&it=r&id=GALE%7CA470967176&linkaccess=fulltext&authCount=1&isAnonymousEntry=true
Adenomyoma | Radiology Reference Article | Radiopaedia.org  Adenomyoma | Radiology Reference Article | Radiopaedia.org
An adenomyoma is a focal region of adenomyosis resulting in a mass, which is difficult to distinguish from a uterine fibroid, ... An adenomyoma is a focal region of adenomyosis resulting in a mass, which is difficult to distinguish from a uterine fibroid, ... Some authors draw a distinction between focal adenomyosis and adenomyoma. Adenomyomas, they contend, are a focal form of ...
more infohttps://radiopaedia.org/articles/adenomyoma
Atypical polypoid adenomyoma legal definition of atypical polypoid adenomyoma  Atypical polypoid adenomyoma legal definition of atypical polypoid adenomyoma
What is atypical polypoid adenomyoma? Meaning of atypical polypoid adenomyoma as a legal term. What does atypical polypoid ... Definition of atypical polypoid adenomyoma in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... redirected from atypical polypoid adenomyoma). Also found in: Dictionary, Medical, Financial, Encyclopedia. APA. abbreviation ... Atypical polypoid adenomyoma mixed with endometrioid carcinoma: A case report.. Serous adenocarcinoma of endometrium ...
more infohttp://legal-dictionary.thefreedictionary.com/atypical+polypoid+adenomyoma
Atypical polypoid adenomyoma - Wikipedia  Atypical polypoid adenomyoma - Wikipedia
Atypical polypoid adenomyoma, abbreviated APA, is a rare uncommon benign tumour of the uterus. APAs are characterized by glands ... Adenomyoma Cervical cancer Intermed. mag. Very high mag. Jakus, S.; Edmonds, P.; Dunton, C.; Holland, G. (Jan 2002). "Atypical ... polypoid adenomyoma mimicking cervical adenocarcinoma". J Low Genit Tract Dis. 6 (1): 33-8. doi:10.1046/j.1526-0976.2002.61007. ...
more infohttps://en.wikipedia.org/wiki/Atypical_polypoid_adenomyoma
Adenomyoma With Pseudoinvasive Growth Pattern and Serosal Penetration Mimicking Endometrial Carcinoma  Adenomyoma With Pseudoinvasive Growth Pattern and Serosal Penetration Mimicking Endometrial Carcinoma
We present a novel case of a 48-yr-old female with a uterine adenomyoma with an unusual pseudoinvasive growth pattern ... To our knowledge, this unique presentation of a pseudoinvasive adenomyoma extending beyond the serosa is extremely rare and is ... and a prominent smooth muscle component consistent with an adenomyoma. ...
more infohttps://insights.ovid.com/ijgyp/201807000/00004347-201807000-00015
Primary ovarian adenomyoma in a woman with endometrial polyp: a case report and review of the literature | springermedizin.de  Primary ovarian adenomyoma in a woman with endometrial polyp: a case report and review of the literature | springermedizin.de
An adenomyoma presenting outside the uterus is an extremely rare entity and only three cases of primary ovarian adenomyoma have ... Primary ovarian adenomyoma in a woman with endometrial polyp: a case report and review of the literature. Zeitschrift:. ... Primary ovarian adenomyoma in a woman with endometrial polyp: a case report and review of the literature ... Jung W, Shin B, Kim I (2002) Uterine adenomyoma with uterus-like features. Int J Surg Pathol 10:163-166. doi: 10.​1177/​ ...
more infohttps://www.springermedizin.de/primary-ovarian-adenomyoma-in-a-woman-with-endometrial-polyp-a-c/8421276
Betekenis adenomyoma uteri  Betekenis adenomyoma uteri
adenomyoma uteri. Betekenis adenomyoma uteri. De betekenis van adenomyoma uteri is: "endometriose in het myometrium met ... Defenitie adenomyoma uteri. De definitie van adenomyoma uteri is: "endometriose in het myometrium met gezamenlijke groei van ...
more infohttp://mijnwoordenboek.info/adenomyoma+uteri
Extrauterine adenomyoma of the liver with a focally cellular smooth muscle component occurring in a patient with a history of...  Extrauterine adenomyoma of the liver with a focally cellular smooth muscle component occurring in a patient with a history of...
In this report, we present the first case of extrauterine adenomyoma involving the liver in a 29-year-old woman who presented ... 14 cases of extrauterine adenomyoma have been reported in the English literature, most often occurring in the ovaries. ... we present the fifteenth case of extrauterine adenomyoma and the first case of hepatic adenomyoma. The 15 patients ranged from ... Extrauterine adenomyoma of the liver with a focally cellular smooth muscle component occurring in a patient with a history of ...
more infohttps://diagnosticpathology.biomedcentral.com/articles/10.1186/1746-1596-8-131
GE - Portuguese Journal of Gastroenterology 2017, Vol. 24, No. 4 - Karger Publishers  GE - Portuguese Journal of Gastroenterology 2017, Vol. 24, No. 4 - Karger Publishers
Gastric Adenomyoma: The Unexpected Mimicker. Abstract Duran Álvarez M.A. · Gómez López J.R. · Guerra Garijo T. GE Port J ...
more infohttps://www.karger.com/Journal/Issue/276576
Anterior placenta grade 2 - Answers on HealthTap  Anterior placenta grade 2 - Answers on HealthTap
Adenomyoma. Near internal os ill-defined structure 5x12mm. Cannot rule out polyp v scar. ...
more infohttps://www.healthtap.com/topics/anterior-placenta-grade-2
Catarina Eloy  Catarina Eloy
Multilocular adenomyoma of seminal vesicle.. Authors:. Alice Vanzati Adriana Pérez Pascal Fernanda Pinto Catarina Eloy ...
more infohttps://www.pubfacts.com/author/Catarina+Eloy
APA | definition of APA by Medical dictionary  APA | definition of APA by Medical dictionary
atypical polypoid adenomyoma. An uncommon biphasic polypoid lesion seen in the middle-aged (mean age: 40) uterine cervix and ...
more infohttps://medical-dictionary.thefreedictionary.com/APA
Apas | definition of Apas by Medical dictionary  Apas | definition of Apas by Medical dictionary
atypical polypoid adenomyoma. An uncommon biphasic polypoid lesion seen in the middle-aged (mean age: 40) uterine cervix and ...
more infohttp://medical-dictionary.thefreedictionary.com/Apas
Table of Contents - September 30, 1967, 3 (5569) | The BMJ  Table of Contents - September 30, 1967, 3 (5569) | The BMJ
Adenomyoma of the stomach. Br Med J 1967; 3 :843 (Published 30 September 1967) ...
more infohttp://www.bmj.com/content/3/5569
  • Focal adenomyoma has characteristic features including a poorly defined border, minimal mass effect on the endometrium compared to a leiomyoma of same size, an elliptical rather than round configuration, may display linear striations radiating out from endometrium, and shows no dilated vessels at the margin of the lesion. (thefreedictionary.com)
  • In the case of juvenile cystic adenomyoma, laparoscopic enucleation results in a statistically and clinically significant reduction in dysmenorrhea, ease in any chronic pelvic pain, and low risk of recurrence. (wikipedia.org)
  • A typical feature of an adenomyoma is a poorly marginated mass with ill-defined borders that causes relatively little mass effect (Figure 3). (appliedradiology.com)
  • Total abdominal hysterectomy and bilateral salpingo-oopherectomy was performed and histologic examination revealed an adenomyoma arising primarily in the ovary. (springermedizin.de)
  • To our knowledge, this unique presentation of a pseudoinvasive adenomyoma extending beyond the serosa is extremely rare and is the first time reported in the literature. (ovid.com)