Adenomatous Polyps: Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)Colonic Polyps: Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.Polyps: Discrete abnormal tissue masses that protrude into the lumen of the DIGESTIVE TRACT or the RESPIRATORY TRACT. Polyps can be spheroidal, hemispheroidal, or irregular mound-shaped structures attached to the MUCOUS MEMBRANE of the lumen wall either by a stalk, pedunculus, or by a broad base.Adenomatous Polyposis Coli: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.Intestinal Polyps: Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.Adenoma: A benign epithelial tumor with a glandular organization.Colonoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the colon.Adenomatous Polyposis Coli Protein: A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Colonic Neoplasms: Tumors or cancer of the COLON.Nasal Polyps: Focal accumulations of EDEMA fluid in the NASAL MUCOSA accompanied by HYPERPLASIA of the associated submucosal connective tissue. Polyps may be NEOPLASMS, foci of INFLAMMATION, degenerative lesions, or malformations.Sigmoidoscopy: Endoscopic examination, therapy or surgery of the sigmoid flexure.Colonography, Computed Tomographic: A non-invasive imaging method that uses computed tomographic data combined with specialized imaging software to examine the colon.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Rectal Neoplasms: Tumors or cancer of the RECTUM.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Rectum: The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.Barium Sulfate: A compound used as an x-ray contrast medium that occurs in nature as the mineral barite. It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield.Gardner Syndrome: A variant of ADENOMATOUS POLYPOSIS COLI caused by mutation in the APC gene (GENES, APC) on CHROMOSOME 5. It is characterized by not only the presence of multiple colonic polyposis but also extracolonic ADENOMATOUS POLYPS in the UPPER GASTROINTESTINAL TRACT; the EYE; the SKIN; the SKULL; and the FACIAL BONES; as well as malignancy in organs other than the GI tract.Cecal Neoplasms: Tumors or cancer of the CECUM.Enema: A solution or compound that is introduced into the RECTUM with the purpose of cleansing the COLON or for diagnostic procedures.Genes, APC: Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Sulindac: A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.Rectal Diseases: Pathological developments in the RECTUM region of the large intestine (INTESTINE, LARGE).Sigmoid Neoplasms: Tumors or cancer of the SIGMOID COLON.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Cystadenoma: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)Occult Blood: Chemical, spectroscopic, or microscopic detection of extremely small amounts of blood.Diverticulum, Colon: A pouch or sac opening from the COLON.Colon, Transverse: The segment of LARGE INTESTINE between ASCENDING COLON and DESCENDING COLON. It passes from the RIGHT COLIC FLEXURE across the ABDOMEN, then turns sharply at the left colonic flexure into the descending colon.Germ-Line Mutation: Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.beta Catenin: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Endoscopy: Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.Fibromatosis, Aggressive: A childhood counterpart of abdominal or extra-abdominal desmoid tumors, characterized by firm subcutaneous nodules that grow rapidly in any part of the body but do not metastasize. The adult form of abdominal fibromatosis is FIBROMATOSIS, ABDOMINAL. (Stedman, 25th ed)Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Mass Screening: Organized periodic procedures performed on large groups of people for the purpose of detecting disease.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Cytoskeletal Proteins: Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Vegetables: A food group comprised of EDIBLE PLANTS or their parts.Adenomatosis, Pulmonary: A neoplastic disease in which the alveoli and distal bronchi are filled with mucus and mucus-secreting columnar epithelial cells. It is characterized by abundant, extremely tenacious sputum, chills, fever, cough, dyspnea, and pleuritic pain. (Stedman, 25th ed)Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Coffee: A beverage made from ground COFFEA beans (SEEDS) infused in hot water. It generally contains CAFFEINE and THEOPHYLLINE unless it is decaffeinated.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.
Incidence of rectosigmoid adenomatous polyps in subjects without prior colorectal adenoma or cancer: a prospective cohort study. (1/224)
BACKGROUND: Subjects without known colorectal adenomas or cancer constitute a large majority of the population where 85% of all cases of colorectal cancer are thought to occur. Consequently these people should be considered for screening to decrease mortality from colorectal cancer in the general population. AIMS: To estimate the incidence rate of rectosigmoid adenomas in these subjects. METHODS: Subjects without adenomas or cancer at a previous examination which had visualised the rectosigmoid underwent a fibre endoscopy every three years. Endoscopic data and population characteristics were collected prospectively. RESULTS: A total of 450 subjects fulfilled the selection criteria; 287 (64%) underwent at least two examinations, and 163 had three or more. At the second examination, with a mean delay of 39 months, the incidence rate of rectosigmoid adenomas was 1.50% per patient year. The rate was 1.75% per patient year (95% CI 0.80-3.33) at the third endoscopy with an additional mean delay of 38 months. The cumulative incidence rate at six years was 7.3% (95% CI 4.3-10.3), representing a mean of 1.2% per patient year. This rate increased with age and was higher for men than for women after age adjustment (p< 0.03). CONCLUSIONS: The incidence rates are very low compared with those of patients with prior adenomas. These results should be considered in establishing rectosigmoid adenoma screening strategies. (+info)Dietary determinants of colorectal proliferation in the normal mucosa of subjects with previous colon adenomas. (2/224)
Dietary determinants of colorectal mucosa proliferation were studied in 69 subjects previously operated for at least two sporadic colon adenomas. Information on recent dietary habits was collected by a validated food frequency questionnaire, and proliferation was measured by [3H]thymidine incorporation in colorectal biopsies by determining the labeling index (LI) and the percentage of LI in the upper part of the crypt, two parameters that are increased in subjects at high risk of colon cancer. The LI was significantly higher in women as compared with men (P = 0.01). Diet showed several associations with colorectal mucosa proliferation: (a) subjects in the highest tertile of fish consumption had a significantly lower LI (P = 0.0013) compared with those in the lower tertiles [5.20 +/- 1.87 versus 6.80 +/- 2.18 (mean +/- SD)]; (b) subjects with a low red meat consumption had lower proliferation in the upper part of the crypt [2.38 +/- 2.10, 5.30 +/- 4.62, and 5.89 +/- 4.82 in the low, middle, and high tertile of consumption, respectively (mean +/- SD); P = 0.0093]; (c) according to estimated nutrient intakes, the LI was lower in subjects reporting a high intake of starch (P = 0.006) and higher in subjects with a low intake of beta-carotene (P = 0.002). The results show that subjects reporting a diet rich in fish, starch, and beta-carotene and low in red meat had lower colorectal mucosa proliferation and a normal pattern of proliferation along the crypt. Given the correlation between colorectal proliferative activity and colon cancer risk, such a dietary pattern might be beneficial for subjects at high risk of colon cancer. (+info)Flat adenomas exist in asymptomatic people: important implications for colorectal cancer screening programmes. (3/224)
BACKGROUND: Flat adenomas are non-exophytic with a flat top or central depression and histologically the depth of dysplastic tissue is never more than twice the mucosal thickness. Flat adenomas frequently contain severely dysplastic tissue, and may progress rapidly through the adenoma-carcinoma sequence. Flat lesions have never been described in a British asymptomatic population. AIMS: To determine whether flat adenomas exist in an asymptomatic population participating in a large randomised controlled trial of flexible sigmoidoscopy screening. PATIENTS: A total of 3000 subjects (aged 55-64 years) underwent screening by flexible sigmoidoscopy. METHODS: All polyps were removed and sent for histology. The number of polyps with endoscopic and histological features of flat adenomas was recorded. RESULTS: Three subjects had a total of four flat lesions--that is, one per 1000 people screened. Three contained severely dysplastic tissue, one a focus of adenocarcinoma. Three of the four lesions were less than 5 mm in size and the fourth was 15 mm in diameter. CONCLUSIONS: Flat lesions with severe dysplasia exist in the asymptomatic population. This has major implications for gastroenterologists who should be trained to identify them. Their existence is of importance to molecular biologists and epidemiologists investigating the aetiology of colorectal cancer. (+info)Effect of aspirin on prostaglandin E2 formation and transforming growth factor alpha expression in human rectal mucosa from individuals with a history of adenomatous polyps of the colon. (4/224)
Colorectal cancer is the second-most frequent cause of cancer mortality in the United States. Human epidemiology and laboratory studies indicate that aspirin may be an effective colorectal cancer chemopreventive agent. This study was designed to determine whether treatment with 81 mg of aspirin per day for 3 months would alter two putative surrogate end point biomarkers of chemoprevention of colorectal cancer [i.e., mucosal prostaglandin E2 (PGE2) formation and transforming growth factor alpha (TGF-alpha) expression] in normal-appearing rectal mucosa from individuals with a history of adenomatous polyps. Rectal biopsies were obtained by flexible sigmoidoscopy at three sequential time points: (a) after a 1-month placebo run-in period (baseline), (b) after 3 months of ingesting 81 mg of aspirin (as a single tablet) once per day, and (c) after 3 months of ingesting a placebo tablet once per day (washout period). Daily aspirin significantly suppressed PGE2 formation, but this significant suppression was completely reversed when aspirin was withdrawn. The extent of TGF-alpha staining in rectal crypts was also reduced significantly (P = 0.039) by daily aspirin. After a 3-month placebo-washout period, however, the mean extent of TGF-alpha staining was not significantly different from either baseline or the aspirin time point. Thus, 81 mg of aspirin daily significantly reduced rectal mucosal PGE2 formation and TGF-alpha expression in patients with a history of adenomatous polyps. These putative surrogate end point biomarkers may be useful intermediate end points in future colorectal cancer chemoprevention trials. (+info)Evaluation of 5-aminosalicylic acid (5-ASA) for cancer chemoprevention: lack of efficacy against nascent adenomatous polyps in the Apc(Min) mouse. (5/224)
Recent experimental and epidemiological evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the prevention of colorectal cancer. However, the toxicity associated with the long-term use of most classical NSAIDs has limited their usefulness for the purpose of cancer chemoprevention. Inflammatory bowel disease (IBD) patients, in particular, are sensitive to the adverse side effects of NSAIDs, and these patients also have an increased risk for the development of intestinal cancer. 5-Aminosalicylic acid (5-ASA) is an anti-inflammatory drug commonly used in the treatment of IBD and may provide protection against the development of colorectal cancer in these patients. To directly evaluate the ability of 5-ASA to suppress intestinal tumors, we studied several formulations of 5-ASA (free acid, sulfasalazine, and Pentasa) at multiple oral dosage levels [500, 2400, 4800, and 9600 parts/million (ppm)] in the adenomatous polyposis coli (Apc) mouse model of multiple intestinal neoplasia (Min). Although the ApcMin mouse is not a model of colitis-associated neoplasia, it is, nonetheless, a useful model for assessing the ability of anti-inflammatory agents to prevent tumor formation in a genetically preinitiated population of cells. We used a study design in which drug was provided ad libitum through the diet beginning at the time of weaning (28 days of age) until 100 days of age. We included 200 ppm of piroxicam and 160 ppm of sulindac as positive controls, and the negative control was AIN-93G diet alone. Treatment with either piroxicam or sulindac produced statistically significant reductions in intestinal tumor multiplicity (95% and 83% reductions in tumor number, respectively; P < 0.001 versus controls). By contrast, none of the 5-ASA drug formulations or dosage levels produced consistent dose-progressive changes in polyp number, distribution, or size, despite high luminal and serum concentrations of 5-ASA and its primary metabolite N-acetyl-5-ASA. Thus, 5-ASA does not seem to possess direct chemosuppressive activity against the development of nascent intestinal adenomas in the ApcMin mouse. However, because intestinal tumor development in the ApcMin mouse is driven by a germline mutation in the Apc gene rather than by chronic inflammation, we caution that these findings do not definitively exclude the possibility that 5-ASA may exert a chemopreventive effect in human IBD patients. (+info)A case-control study of colorectal adenomatous polyps and consumption of foods containing partially hydrogenated oils. (6/224)
The trans fatty acids produced by partially hydrogenating vegetable oils may cause colorectal neoplasia by interfering with cell membrane function or eicosanoid synthesis. This possibility provides a rationale for looking at the relation between colorectal adenomatous polyps and consumption of foods containing partially hydrogenated vegetable oils (PHVOs). A total of 516 cases and 551 controls who underwent screening sigmoidoscopy from 1991-1993 were recruited from a prepaid Los Angeles health plan. Subjects were interviewed and given a self-administered food frequency questionnaire. Food items containing PHVOs were divided into four groups characterized by principal ingredients and preparation methods: sweetened baked goods, candy bars, oils and condiments, and french fries and chips. After adjusting for age, sex, physical activity, body mass index, smoking, total energy, and red meat and vegetable intake, there was a positive association between polyps and sweetened baked goods [350+ versus <50 kcal/day (odds ratio, 2.1; 95% confidence interval, 1.3-3.5)]. No association was found with the other food groups after adjustment for dietary and nondietary covariates. Neither was total dietary trans fatty acid associated with adenomas after adjustment for sweetened baked goods and other covariates. These results do not support the hypothesis that eating foods containing PHVOs increases the risk of colorectal adenomas, but they are consistent with the hypothesis that foods high in fat and sugar and low in fiber and correlated micronutrients increase the risk of adenomas. (+info)Reliability and validity of a self-administered food frequency questionnaire in a chemoprevention trial of adenoma recurrence. (7/224)
Various chemoprevention trials have assessed dietary intake by means of food frequency questionnaires. However, it is important to assess the degree to which such questionnaires can measure diet. We conducted reproducibility and validity analyses of our Arizona Food Frequency Questionnaire (AFFQ) in our recently completed, randomized, Phase III chemoprevention trial testing the effects of a wheat bran fiber supplement on colorectal adenoma recurrence. A total of 139 individuals provided a baseline and year 1 AFFQ and a set of 4-day dietary records collected over a period of 1 month. The reproducibility analyses of the AFFQ administered 1 year apart showed a mean intraclass correlation of 0.54 for unadjusted nutrients and 0.48 for energy-adjusted nutrients. The relative validity of the AFFQ, as compared with the average of the 4-day diet records, showed a mean deattenuated correlation of 0.49 (range, 0.22-0.65) for the baseline AFFQ and 0.49 (range, 0.25-0.67) for the year 1 AFFQ. When data from both AFFQs were combined and compared with the diet records, there was a slight improvement in the overall deattenuated correlations (mean, 0.56; range, 0.33-0.71). The correlations we observed for macro- and micronutrient intake were within the overall range of those reported in the literature. Reliability and validity studies of dietary instruments are feasible in the setting of a chemoprevention trial and should be conducted when the instrument's performance has not been previously assessed in the target population. (+info)Patterns of proliferative changes in crypts bordering colonic tumors: zonal histology and cell cycle marker expression. (8/224)
Proliferative crypt changes have been noted in mucosa bordering colonic carcinomas, but their biological significance is disputed. We anticipated that zonal patterning of histological changes and cell cycle marker expression would provide clues to the pathogenesis of these border changes. 81 specimens were examined including carcinomas, adenomatours polyps, adenomas with early carcinoma, flat adenomas and aberrant crypt foci. The spatial distribution and frequency of micro-architectural features, and mucosal thickness were determined in a border domain of 150 300 sequential crypts/specimen. Immunocytochemical expression of Ki67 and p53 antigens in crypts also was semi-quantitatively examined. We found that in 100% of carcinomas two histologically abnormal zones (Proximate and Middle) separated tumor from normal mucosa. Differences in the feature frequency between zones were statistically significant (p<0.05). Both zones showed mild increases in crypt cell expression of Ki67, with a statistically significant relationship to zonal patterning (p<0.005). Weak expression of p53 only appeared in rare cells. Crypt elongation with mucosal thickening (1.9x normal, p<0.001) in the Proximate and Middle zones distinguished carcinomas from border changes in all benign lesions, except flat adenomas. Since this change occurs in all cases of carcinoma, there is no correlation with tumor stage or grade. Also in carcinomas, elaborate complexes of attached crypts (connected crypt structures) were characteristic of the Middle zone, so that proximate zone was always architecturally simpler. We conclude, that despite continuous carcinoma growth, the invaded border mucosa maintains a prototypical zonal organization of molecular and histological crypt changes This spatially organized reaction pattern is likely to reflect an interplay between regulated growth and destructive processes in response to advancing carcinoma. Compared to the edges of benign colonic tumors, the edges of carcinomas are distinctive and consistent enough to be diagnostically useful. (+info)Villous adenoma Colorectal polyp Levine JS, Ahnen DJ (December 2006). "Clinical practice. Adenomatous polyps of the colon". N. ... Tubulovillous adenoma, TVA, is a type of polyp that grows in the colon and other places in the gastrointestinal tract and ...
Adenomatous polyps of the colon" (PDF). N. Engl. J. Med. 355 (24): 2551-7. doi:10.1056/NEJMcp063038. PMID 17167138. Intestinal ... Polyp table Colonic polyps Colorectal polyps Colorectal carcinoma Microsatellite instability Rüschoff J, Aust D, Hartmann A ( ... In gastroenterology, a sessile serrated adenoma (abbreviated SSA), also known as sessile serrated polyp (abbreviated SSP), is a ... is a relatively rare condition characterized by multiple and/or large serrated polyps of the colon. Diagnosis of this disease ...
"Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps". Cochrane Database Syst Rev (Review) ( ... is weak evidence calcium supplementation might have a preventative effect against developing colorectal adenomatous polyps, but ...
Drinking 5 glasses of water a day is linked to a decrease in the risk of colorectal cancer and adenomatous polyps. ... As more than 80% of colorectal cancers arise from adenomatous polyps, screening for this cancer is effective not only for early ... During colonoscopy, small polyps may be removed if found. If a large polyp or tumor is found, a biopsy may be performed to ... If a villous polyp, a polyp >1 centimeter or high grade dysplasia is found, it can be repeated after 3 years, then every 5 ...
In hollow organs (digestive tract), the adenoma grows into the lumen - adenomatous polyp or polypoid adenoma. Depending on the ... Adenomas of the colon, also called adenomatous polyps, are quite prevalent. They are found commonly at colonoscopy. They are ... In the common case of removing one or two of these polyps from the colon from a patient with no particular risk factors for ... example of treatment is the response recommended by specialty professional organizations upon removing adenomatous polyps from ...
In 2001, Merck commenced the APPROVe (Adenomatous Polyp PRevention On Vioxx) study, a three-year trial with the primary aim of ... Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators (2005). "Cardiovascular events associated with rofecoxib in ... evaluating the efficacy of rofecoxib for the prophylaxis of colorectal polyps. Celecoxib had already been approved for this ...
Familial Adenomatous Polyposis (FAP) is a hereditary disease that is characterized with development of numerous colon polyps. A ... 1998). "Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice". Cancer Res. 58 (6): 1087-9. PMID 9515784. Engle ... The Min mouse can develop up to 100 polyps in the small intestine in addition to colon tumors. Later, new knock-out mutants of ... In this model mutation in the Cdx2 gene in the ApcΔ716 mouse model shifted the formation of the polyps from the intestine to ...
Affected individuals develop hundreds of polyps in their large intestine. Most of these polyps are benign in nature, but they ... β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis ... Although one molecule of axin only contains a single β-catenin recruitment motif, its partner the Adenomatous Polyposis Coli ( ... Through its N-terminal regulator of G-protein signaling (RGS) domain, it recruits the adenomatous polyposis coli (APC) protein ...
In this disorder adenomatous polyps are present in the colon that invariably progress into colon cancer. The APC gene is a ... vocal chord polyps and hyperplastic polyps of the colon are often referred to as benign but they are actually overgrowths of ... A prominent and well studied example of this phenomenon is the tubular adenoma, a common type of colon polyp which is an ... Familial adenomatous polyposis (FAP) is a familial cancer syndrome caused by mutations in the APC gene. ...
In familial adenomatous polyposis physicians observed polyps regression with NSAIDs for anti-inflammatory therapy.[citation ...
The development of adenomatous polyps created by uncontrolled outgrowth of epithelial cells is controlled by ephrin-eph ...
Individuals with familial adenomatous polyposis (FAP), a syndrome of early-onset colonic polyps and adenocarcinoma, frequently ... Sanders RP, Furman WL (November 2006). "Familial adenomatous polyposis in two brothers with hepatoblastoma: implications for ... "The spectrum of APC mutations in children with hepatoblastoma from familial adenomatous polyposis kindreds". J. Pediatr. 147 (2 ...
Gaspar, C (2008). "Cross-Species Comparison of Human and Mouse Intestinal Polyps Reveals Conserved Mechanisms in Adenomatous ...
Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. ...
COX-2 inhibitors may decrease the rate of polyp formation in people with familial adenomatous polyposis; however, it is ... Folic acid supplementation is not effective in preventing colon cancer and may increase colon polyps. It is unclear if selenium ...
Sagara T, Tsukada K, Iwama T, Mishima Y, Sakamoto S, Okamoto R (1985). "[Thymidine kinase isozymes in human colon polyps]". ... Sakamoto S, Okamoto R (1992). "Thymidine kinase activity in familial adenomatous polyposis". The Tohoku Journal of Experimental ... in cancer and polyps in colon, in breast cancer, in lung cancer, in gastric cancers, in ovarian cancer, in mesotheliomas, in ... "Increased activities of thymidine kinase isozymes in human colon polyp and carcinoma". Carcinogenesis. 6 (6): 917-9. doi: ...
Related polyposis conditions are familial adenomatous polyposis, attenuated familial adenomatous polyposis, Birt-Hogg-Dubé ... Polyps are most frequent in the stomach and large intestine, are also found in the small intestine, and are least frequent in ... Cronkhite-Canada syndrome is a rare syndrome characterized by multiple polyps of the digestive tract. It is sporadic (i.e. it ... Other conditions consisting of multiple hamartomatous polyps of the digestive tract include Peutz-Jeghers syndrome, juvenile ...
Gardener syndrome characterized by FAP (Familial Adenomatous Polyps), osseous and soft tissue tumors, retinal pigment ...
... in addition to multiple adenomatous polyps of the colon. Gardner syndrome is also associated with familial adenomatous ... The number of polyps increases with age, and hundreds to thousands of polyps can develop in the colon. The syndrome was first ... Gardner syndrome consists of adenomatous polyps of the gastrointestinal tract, desmoid tumours, osteomas, epidermoid cysts, ... The countless polyps in the colon predispose to the development of colon cancer; if the colon is not removed, the chance of ...
Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic ...
... in adenomatous polyposis M8221/0 Multiple adenomatous polyps M8221/3 Adenocarcinoma in multiple adenomatous polyps M8230/2 ... M8204/0 Lactating adenoma M8210/0 Adenomatous polyp, NOS Polypoid adenoma M8210/2 Adenocarcinoma in situ in adenomatous polyp ... Mixed adenomatous and hyperplastic polyp M8214/3 Parietal cell carcinoma (C16._) Parietal cell adenocarcinoma M8215/3 ... NOS Carcinoma in situ in a polyp, NOS M8210/3 Adenocarcinoma in adeonmatous polyp Adenocarcinoma in tubular adenoma Carcinoma ...
1992). "Gastroduodenal polyps in patients with familial adenomatous polyposis". Diseases of the colon and rectum. 35 (12): 1170 ... polyps. In familial adenomatous polyposis, the abnormality is a mutation in the APC gene, resulting in its inactivity. ... "Sporadic Fundic Gland Polyps : Common Gastric Polyps Arising Through Activating Mutations in the β-Catenin Gene". The American ... there is a reverse relationship between infection and fundic gland polyps, and infection by H pylori causes polyps regression. ...
Savicol has been entered into Phase II studies by TopoTarget for the treatment of colorectal polyps in FAP patients. Orphan ... is an anti-cancer drug candidate that treats familial adenomatous polyposis (FAP). Savicol delivers valproic acid as a ...
Familial Adenomatous Polyposis is caused by a deletion of the APC tumor suppressor gene on the long (q) arm of chromosome 5. ... This chromosomal change results in thousands of colonic polyps which gives the patient a 100% risk of colon cancer if total ... Lange syndrome Corneal dystrophy of Bowman layer Cri du chat Diastrophic dysplasia Ehlers-Danlos syndrome Familial adenomatous ...
From epidemiological data, it has been stated that diverticular disease and adenomatous polyps were unknown and colon cancer ...
colorectal polyp: Peutz-Jeghers syndrome. *Juvenile polyposis syndrome. *Familial adenomatous polyposis/Gardner's syndrome ...
Mixed hyperplastic/adenomatous polyps - a collision. ,i,Colorectal Disease,/i,, 10 (1), pp. 96-98. https://doi.org/10.1111/j. ... Biyani DK, Skordilis K & Watson A (2008) Mixed hyperplastic/adenomatous polyps - a collision. Colorectal Disease, 10 (1), pp. ...
COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics. / McLean, M. H.; Murray, G. I. ... COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics. Histopathology. 2008 Jun;52(7 ... title = "COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics", ... T1 - COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics ...
... or familial adenomatous polyposis were excluded. Results: A total of 2,498 patients and 4,591 adenomatous polyps were included ... or familial adenomatous polyposis were excluded. Results: A total of 2,498 patients and 4,591 adenomatous polyps were included ... or familial adenomatous polyposis were excluded. Results: A total of 2,498 patients and 4,591 adenomatous polyps were included ... or familial adenomatous polyposis were excluded. Results: A total of 2,498 patients and 4,591 adenomatous polyps were included ...
Gardner syndrome is a genetic disorder characterized by multiple intestinal polyps, dental abnormalities, multiple osteomas, ... Since benign polyps in the colon and rectum appear at an average age of 16 years, regular screening of patients starts as early ... The disease occurs due to the mutations in Adenomatous Polyposis Coli (APC) gene - a tumor suppressor gene that encodes ... Intestinal polyps are the main concern for patients with Gardner syndrome because of their tendency to become cancerous. ...
A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME. ... replacing its function may reduce polyp formation. ". 05/01/1999 - "Expression of E-cadherin, alpha, beta and gamma-catenin and ... Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 01/01/2008 - "The adenomatous polyposis coli gene functions as a ... Adenomatous Polyposis Coli Protein. Subscribe to New Research on Adenomatous Polyposis Coli Protein ...
Adenomatous polyp definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it ... adenomatous polyp. adenomatoid, adenomatoid tumor, adenomatosis, adenomatous, adenomatous goiter, adenomatous polyp, adenomere ... A polyp that consists of benign neoplastic tissue derived from glandular epithelium. ...
The White House said today that pathology on five adenomatous polyps discovered during a colonoscopy performed on President ... Bush Adenomatous Polyps Determined Benign. by Mark Bloom, Editor-in-Chief, MedPage Today July 23, 2007 ... WASHINGTON, July 23 -- The White House said today that pathology on five adenomatous polyps discovered during a colonoscopy ... Because five polyps were found, Bush will have another colononscopy exam in three years, said spokesman Tony Snow. Although no ...
Celecoxib for the prevention of colorectal adenomatous polyps.. Arber N1, Eagle CJ, Spicak J, Rácz I, Dite P, Hajer J, Zavoral ... The Prevention of Colorectal Sporadic Adenomatous Polyps trial was a randomized, placebo-controlled, double-blind study of the ... Overexpression of cyclooxygenase 2 (COX-2) has been associated with colorectal adenomatous polyps and cancer, prompting ...
The findings from epidemiological studies addressing the association between adiposity and the risk of colorectal adenomatous ... polyps are inconsistent. We performed a meta-analysis of... ... Levine JS, Ahnen DJ (2006) Adenomatous polyps of the colon. N ... Shinchi K, Kono S, Honjo S et al (1994) Obesity and adenomatous polyps of the sigmoid colon. Jpn J Cancer Res 85:479-484PubMed ... Neugut AI, Lee WC, Garbowski GC et al (1991) Obesity and colorectal adenomatous polyps. J Natl Cancer Inst 83:359-361PubMed ...
Cigarettes, alcohol, coffee, and caffeine as risk factors for colorectal adenomatous polyps.. Lee WC1, Neugut AI, Garbowski GC ... The possible association of colorectal adenomatous polyps, a precursor lesion for colorectal cancer, with cigarette smoking, ... Between April 1986 and March 1988, 271 cases of patients with pathologically confirmed incident colorectal adenomatous polyps ... Adjustment for cigarette smoking eliminated the association between colorectal adenomatous polyps and coffee consumption in ...
Prevention of Colorectal Sporadic Adenomatous Polyps (PRESAP) (PRESAP). The safety and scientific validity of this study is the ... Adenomatous Polyps. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. Celecoxib. Anti-Inflammatory ... Celecoxib for the prevention of colorectal adenomatous polyps. N Engl J Med. 2006 Aug 31;355(9):885-95. ... Five-year analysis of the prevention of colorectal sporadic adenomatous polyps trial. Am J Gastroenterol. 2011 Jun;106(6):1135- ...
Removed no more than 10 adenomatous polyps of any size by endoscopy. - All other neoplastic and non-neoplastic colon polyps ... Phase III Study of the Effects of Selenium on Adenomatous Polyp Recurrence. Trial Phase:. Phase 3. Minimum Age:. 40 Years. ... adenomatous polyp during procedure. An adenoma is considered advanced if it is. 10 mm or greater in size, and/or has villous ... in patients with adenomatous colorectal polyps.. - Compare the type, incidence, and outcome of side effects in patients treated ...
... and antonyms of the term ADENOMATOUS POLYP in the Online Dictionary. ... ADENOMATOUS POLYP: Review the definition, meaning, pronunciation, explanation, synonyms, ... n] a polyp that consists of benign neoplastic tissue derived from glandular epithelium; "adenomatous polyps are visible ...
Shifts in the Fecal Microbiota Associated with Adenomatous Polyps. Vanessa L. Hale, Jun Chen, Stephen Johnson, Sean C. ... Shifts in the Fecal Microbiota Associated with Adenomatous Polyps. Vanessa L. Hale, Jun Chen, Stephen Johnson, Sean C. ... Shifts in the Fecal Microbiota Associated with Adenomatous Polyps. Vanessa L. Hale, Jun Chen, Stephen Johnson, Sean C. ... Background: Adenomatous polyps are the most common precursor to colorectal cancer, the second leading cause of cancer-related ...
Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo George Zonios, Lev T. Perelman, Vadim Backman, ... Diffuse reflectance spectra were collected from adenomatous colon polyps (cancer precursors) and normal colonic mucosa of ... "Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo," Appl. Opt. 38, 6628-6637 (1999) ... Normal and adenomatous tissue sites exhibited differences in hemoglobin concentration and, on average, in effective scatterer ...
... placebo controlled calcium supplementation on sigmoidal cell proliferation in patients with sporadic adenomatous polyps Gut. ...
Multi-Target Colorectal Cancer Screening Test for the Detection of Colorectal Advanced Adenomatous Polyps and Cancer (DeeP-C). ... Multi-Target Colorectal Cancer Screening Test for the Detection of Colorectal Advanced Adenomatous Polyps and Cancer: DeeP-C ... Adenomatous Polyps. Gastrointestinal Diseases. Digestive System Diseases. Intestinal Diseases. Rectal Diseases. Adenoma. ... Familial adenomatous polyposis (also referred to as FAP, including attenuated FAP).. *Hereditary non-polyposis colorectal ...
... reduction in polyp number (p=0.012) and a 29.8% (3.6% to 56.1%) decrease in the sum of polyp diameters (p=0.027). Global polyp ... Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis ... Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis ... Global rectal polyp burden was scored (−1, 0, +1) by examination of video endoscopy records. Mucosal fatty acid content was ...
... with adenomatous polyps or a history of adenomatous polyps before and after 1 week of calcium supplementation p.o. (CaCO3; 2500 ... and tyrosine kinase activities in patients with adenomatous polyps or a history of adenomatous polyps and whether this is ... Supplemental Calcium Suppresses Colonic Mucosal Ornithine Decarboxylase Activity in Elderly Patients with Adenomatous Polyps. ... Supplemental Calcium Suppresses Colonic Mucosal Ornithine Decarboxylase Activity in Elderly Patients with Adenomatous Polyps ...
No Association between Fatty Acid Intake and Adenomatous Polyp Recurrence in the Polyp Prevention Trial. Marie M. Cantwell, ... No Association between Fatty Acid Intake and Adenomatous Polyp Recurrence in the Polyp Prevention Trial ... No Association between Fatty Acid Intake and Adenomatous Polyp Recurrence in the Polyp Prevention Trial ... No Association between Fatty Acid Intake and Adenomatous Polyp Recurrence in the Polyp Prevention Trial ...
Diagnostic Accuracy of Laxative-Free Computed Tomographic Colonography for Detection of Adenomatous Polyps in Asymptomatic ... Diagnostic Accuracy of Laxative-Free Computed Tomographic Colonography for Detection of Adenomatous Polyps in Asymptomatic ... French comment on article The clinical significance and synchronous polyp burden of large (≥ 20mm) sessile serrated polyps in ...
Risk for Colorectal Cancer in Persons With a Family History of Adenomatous Polyps: A Systematic Review Annals of Internal ... Family History of Colorectal Adenomatous Polyps and Increased Risk for Colorectal Cancer Habibul Ahsan, MBBS, MMedSc; Alfred I ... Family History of Colorectal Adenomatous Polyps and Increased Risk for Colorectal Cancer. Ann Intern Med. 1998;128:900-905. doi ...
CRC largely can be prevented by the detection and removal of adenomatous polyps, and survival is significantly better when CRC ... CRC largely can be prevented by the detection and removal of adenomatous polyps, and survival is significantly better when CRC ... Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from ... and the American College of Radiology came together to develop consensus guidelines for the detection of adenomatous polyps and ...
Daily intake of 1 gr dietary calcium may have moderate protective effect on development of colorectal adenomatous polyps. There ... Randomised controlled trials of the effects of dietary calcium on the development of colonic cancer and adenomatous polyps in ... previous adenomatous polyps, or inflammatory bowel disease were considered; data from subjects with familial polyposis coli are ... for dietary supplementation of at least 1200mg elemental calcium per day on the development of colorectal adenomatous polyps. ...
... could enable differentiating hyperplastic from adenomatous polyps (including diminutive polyps). The NICE classification scheme ... All polyps were first detected in the normal far focus mode. Then the colonoscope was moved close to the polyp and the near ... The probability of a hyperplastic or adenomatous polyp (NICE types 1 and 2) is displayed immediately on each endoscopic video ... In addition, the strategy followed here for training the programme to differentiate hyperplastic polyps from adenomatous could ...
- Gardner syndrome is a rare variant of familial adenomatous polyposis - a condition characterized by multiple benign tumors in the colon and rectum that can eventually turn into colorectal cancer. (news-medical.net)
- The number of adenoma specimens was then extended to include polyps exhibiting an increasing degree of epithelial dysplasia. (elsevier.com)
- Fifty-five per cent of the hyperplastic polyp specimens expressed COX-2.Conclusions: This study associates COX-2 epithelial expression with a number of adenoma characteristics that convey an increased risk of malignant transformation. (elsevier.com)
- There was a statistically significant increase in COX-2 expression in colonic polyps compared with paired adjacent normal mucosa, chi(2) = 40.1, P = 0.001. (elsevier.com)
- The main feature of this disorder is the presence of colonic polyps, which is apparent in 80% - 99% of patients. (news-medical.net)
- Since benign polyps in the colon and rectum appear at an average age of 16 years, regular screening of patients starts as early as age 10 years. (news-medical.net)
- If the symptoms left untreated, these polyps may turn into malignant tumors at an average age of 40 years. (news-medical.net)
- Gardner syndrome is a genetic disorder characterized by multiple intestinal polyps, dental abnormalities, multiple osteomas, and mesenchymal tumors of the bone and soft tissues. (news-medical.net)
- Fifty-five per cent of the hyperplastic polyp specimens expressed COX-2. (elsevier.com)
- Intestinal polyps are the main concern for patients with Gardner syndrome because of their tendency to become cancerous. (news-medical.net)
- Detection of additional features like pigmented lesions in the retina, skin abnormalities, and polyps in the stomach and small intestine further supports the diagnosis of Gardner syndrome. (news-medical.net)
- Forty colonic hyperplastic polyps were also identified from the pathology diagnostic database and included in the analysis. (elsevier.com)
- Conclusions: The proportion of adenomatous polyp on the proximal colon significantly increased over the past 10 years. (elsevier.com)
- Patients who had an adenomatous polyp with a diameter of at least 5mm were included. (elsevier.com)
- Results: A total of 2,498 patients and 4,591 adenomatous polyps were included in this study. (elsevier.com)
- Surgical removal of the colon is recommended in patients with multiple advanced polyps. (news-medical.net)
- These patients are generally prescribed with a nonsteroidal anti-inflammatory drug (NSAID), to treat remaining polyps. (news-medical.net)