Adenomatous Polyposis Coli Protein
Adenomatous Polyposis Coli
Genes, APC
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Cytoskeletal Proteins
Glycogen Synthase Kinase 3
Microtubules
Intestinal Polyps
Axin Protein
Intestinal Polyposis
Fibromatosis, Aggressive
Colorectal Neoplasms
Gardner Syndrome
A variant of ADENOMATOUS POLYPOSIS COLI caused by mutation in the APC gene (GENES, APC) on CHROMOSOME 5. It is characterized by not only the presence of multiple colonic polyposis but also extracolonic ADENOMATOUS POLYPS in the UPPER GASTROINTESTINAL TRACT; the EYE; the SKIN; the SKULL; and the FACIAL BONES; as well as malignancy in organs other than the GI tract.
Trans-Activators
Polyps
Mutation
Wnt Proteins
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Fibromatosis, Abdominal
Chromosomes, Human, Pair 5
Germ-Line Mutation
Colonic Polyps
TCF Transcription Factors
Sulindac
A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Proctocolectomy, Restorative
Encyclopedias as Topic
Axin prevents Wnt-3a-induced accumulation of beta-catenin. (1/711)
When Axin, a negative regulator of the Wnt signaling pathway, was expressed in COS cells, it coeluted with glycogen synthase kinase-3beta (GSK-3beta), beta-catenin, and adenomatous polyposis coli protein (APC) in a high molecular weight fraction on gel filtration column chromatography. In this fraction, GSK-3beta, beta-catenin, and APC were co-precipitated with Axin. Although beta-catenin was detected in the high molecular weight fraction in L cells on gel filtration column chromatography, addition of conditioned medium expressing Wnt-3a to the cells increased beta-catenin in the low molecular weight fraction. However, Wnt-3a-dependent accumulation of beta-catenin was greatly inhibited in L cells stably expressing Axin. Axin also suppressed Wnt-3a-dependent activation of Tcf-4 which binds to beta-catenin and acts as a transcription factor. These results suggest that Axin forms a complex with GSK-3beta, beta-catenin, and APC, resulting in the stimulation of the degradation of beta-catenin and that Wnt-3a induces the dissociation of beta-catenin from the Axin complex and accumulates beta-catenin. (+info)EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle. (2/711)
The characteristics of the adenomatous polyposis coli (APC) associated protein EB1 were examined in mammalian cells. By immunocytochemistry EB1 was shown to be closely associated with the microtubule cytoskeleton throughout the cell cycle. In interphase cells EB1 was associated with microtubules along their full length but was often particularly concentrated at their tips. During early mitosis, EB1 was localized to separating centrosomes and associated microtubules, while at metaphase it was associated with the spindle poles and associated microtubules. During cytokinesis EB1 was strongly associated with the midbody microtubules. Treatment with nocodazole caused a diffuse redistribution of EB1 immunoreactivity, whereas treatment with cytochalasin D had no effect. Interestingly, treatment with taxol abolished the EB1 association with microtubules. In nocodazole washout experiments EB1 rapidly became associated with the centrosome and repolymerizing microtubules. In taxol wash-out experiments EB1 rapidly re-associated with the microtubule cytoskeleton, resembling untreated control cells within 10 min. Immunostaining of SW480 cells, which contain truncated APC incapable of interaction with EB1, showed that the association of EB1 with microtubules throughout the cell cycle was not dependent upon an interaction with APC. These results suggest a role for EB1 in the control of microtubule dynamics in mammalian cells. (+info)Analysis of masked mutations in familial adenomatous polyposis. (3/711)
Familial adenomatous polyposis (FAP) is an autosomal-dominant disease characterized by the development of hundreds of adenomatous polyps of the colorectum. Approximately 80% of FAP patients can be shown to have truncating mutations of the APC gene. To determine the cause of FAP in the other 20% of patients, MAMA (monoallelic mutation analysis) was used to independently examine the status of each of the two APC alleles. Seven of nine patients analyzed were found to have significantly reduced expression from one of their two alleles whereas two patients were found to have full-length expression from both alleles. We conclude that more than 95% of patients with FAP have inactivating mutations in APC and that a combination of MAMA and standard genetic tests will identify APC abnormalities in the vast majority of such patients. That no APC expression from the mutant allele is found in some FAP patients argues strongly against the requirement for dominant negative effects of APC mutations. The results also suggest that there may be at least one additional gene, besides APC, that can give rise to FAP. (+info)Administration of an unconjugated bile acid increases duodenal tumors in a murine model of familial adenomatous polyposis. (4/711)
Intestinal carcinogenesis involves the successive accumulation of multiple genetic defects until cellular transformation to an invasive phenotype occurs. This process is modulated by many epigenetic factors. Unconjugated bile acids are tumor promoters whose presence in intestinal tissues is regulated by dietary factors. We studied the role of the unconjugated bile acid, chenodeoxycholate, in an animal model of familial adenomatous polyposis. Mice susceptible to intestinal tumors as a result of a germline mutation in Apc (Min/+ mice) were given a 10 week dietary treatment with 0.5% chenodeoxycholate. Following this, the mice were examined to determine tumor number, enterocyte proliferation, apoptosis and beta-catenin expression. Intestinal tissue prostaglandin E2 (PGE2) levels were also assessed. Administration of chenodeoxycholate in the diet increased duodenal tumor number in Min/+ mice. Promotion of duodenal tumor formation was accompanied by increased beta-catenin expression in duodenal cells, as well as increased PGE2 in duodenal tissue. These data suggest that unconjugated bile acids contribute to periampullary tumor formation in the setting of an Apc mutation. (+info)Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. (5/711)
Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling increases the amount of beta-catenin/Armadillo, which in turn activates gene transcription. Here the Drosophila protein D-Axin was shown to interact with Armadillo and D-APC. Mutation of d-axin resulted in the accumulation of cytoplasmic Armadillo and one of the Wingless target gene products, Distal-less. Ectopic expression of d-axin inhibited Wingless signaling. Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in Drosophila. (+info)Hereditary desmoid disease in a family with a germline Alu I repeat mutation of the APC gene. (6/711)
Two families with autosomal dominantly inherited desmoid tumors have recently been shown to have germline mutations at the 3' end of the APC gene. We subsequently identified an Amish family with autosomal dominantly inherited desmoid tumors. Genetic analysis performed on one family member, a 47-year-old man with multiple desmoid tumors and no colon polyps, revealed a protein truncating mutation in the middle of the APC gene. The truncating mutation is the result of a 337-bp insertion of an Alu I sequence into codon 1526 of the APC gene. The presence of a poly(A) tail at the 3' end of the insertion suggests that the Alu I sequence was inserted by a retrotranspositional event. Germline insertions of Alu I sequences have occasionally been reported to cause other genetic diseases including type I neurofibromatosis, hereditary site-specific breast cancer (BRCA2), and hemophilia B. However, this is the first report of a germline mutation of the APC gene resulting from an Alu I insertion. (+info)E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation. (7/711)
Beta-catenin is a multifunctional protein found in three cell compartments: the plasma membrane, the cytoplasm and the nucleus. The cell has developed elaborate ways of regulating the level and localization of beta-catenin to assure its specific function in each compartment. One aspect of this regulation is inherent in the structural organization of beta-catenin itself; most of its protein-interacting motifs overlap so that interaction with one partner can block binding of another at the same time. Using recombinant proteins, we found that E-cadherin and lymphocyte-enhancer factor-1 (LEF-1) form mutually exclusive complexes with beta-catenin; the association of beta-catenin with LEF-1 was competed out by the E-cadherin cytoplasmic domain. Similarly, LEF-1 and adenomatous polyposis coli (APC) formed separate, mutually exclusive complexes with beta-catenin. In Wnt-1-transfected C57MG cells, free beta-catenin accumulated and was able to associate with LEF-1. The absence of E-cadherin in E-cadherin-/- embryonic stem (ES) cells also led to an accumulation of free beta-catenin and its association with LEF-1, thereby mimicking Wnt signaling. beta-catenin/LEF-1-mediated transactivation in these cells was antagonized by transient expression of wild-type E-cadherin, but not of E-cadherin lacking the beta-catenin binding site. The potent ability of E-cadherin to recruit beta-catenin to the cell membrane and prevent its nuclear localization and transactivation was also demonstrated using SW480 colon carcinoma cells. (+info)Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. (8/711)
Dysregulation of Wnt-beta-catenin signaling disrupts axis formation in vertebrate embryos and underlies multiple human malignancies. The adenomatous polyposis coli (APC) protein, axin, and glycogen synthase kinase 3beta form a Wnt-regulated signaling complex that mediates the phosphorylation-dependent degradation of beta-catenin. A protein phosphatase 2A (PP2A) regulatory subunit, B56, interacted with APC in the yeast two-hybrid system. Expression of B56 reduced the abundance of beta-catenin and inhibited transcription of beta-catenin target genes in mammalian cells and Xenopus embryo explants. The B56-dependent decrease in beta-catenin was blocked by oncogenic mutations in beta-catenin or APC, and by proteasome inhibitors. B56 may direct PP2A to dephosphorylate specific components of the APC-dependent signaling complex and thereby inhibit Wnt signaling. (+info)
Adenomatous Polyposis Coli Protein
Summary Report | CureHunter
adenomatous polyposis coli protein
Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction...
Relationship between the role of the adenomatous polyposis coli protein in colon cancer and its contribution to cytoskeletal...
Neurite outgrowth involves adenomatous polyposis coli protein and β-catenin | Journal of Cell Science
APC2 - Adenomatous polyposis coli protein 2 - Homo sapiens (Human) - APC2 gene & protein
Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes...
Catenin alpha-1 - Wikipedia
Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1)in mice and...
Adenomatous polyposis coli - Wikipedia
2011 Group 5 Project - CellBiology
Difference between revisions of 2011 Group 5 Project - CellBiology
Association of the APC tumor suppressor protein with catenins | Science
The APCs of nerve cell function
Examination of actin and microtubule dependent APC localisations in living mammalian cells | BMC Molecular and Cell Biology |...
Nuclear export of the APC tumour suppressor controls β‐catenin function in transcription | The EMBO Journal
Molecular mechanisms of β‐catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-β‐catenin...
Anti-EB1 [EB1-CL 1A11/4] | Monoclonal Antibodies - Ximbio
1. Evolution or Design? Duons | The Skeptical Zone
1616113-45-1 supplier - casein kinases mediate the phosphorylatable protein pp49
Cell division cycle protein 16 homolog
The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF. - PubMed - NCBI
Citation tools | Cancer Research
APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression | BMC Cancer | Full Text
human AMER1 protein
Summary Report | CureHunter
SAPCD1 - Suppressor APC domain-containing protein 1 - Homo sapiens (Human) - SAPCD1 gene & protein
SAPCD2 Gene - GeneCards | SAPC2 Protein | SAPC2 Antibody
A novel APC promoter 1B deletion shows a founder effect in Italian patients with classical familial adenomatous polyposis...
Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene | SpringerLink
Attenuated adenomatous polyposis coli: The role of ascertainment bias through failure to dye-spray at colonoscopy
Adenomatous Polyposis Coli; Polyposis Coli, Familial; Polyposis Syndrome, Familial
Aberrant methylation of the **Adenomatous Polyposis Coli** (**APC**) gene promoter is associated with the inflammatory breast...
CpG island clones from a deletion encompassing the gene for adenomatous polyposis coli. - Department of Oncology
Familial Adenomatous Polyposis FAP - What Is It, Symptoms, Causes | Lifescript.com
Anti-Rat (Rattus) Adenomatous Polyposis Coli antibody for Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Stavroula Mili, Ph.D. | Principal Investigators | NIH Intramural Research Program
Some fine-structural fi ndings on the thyroid gland in Apc1638T/1638T mice that express a C-terminus lacking truncated Apc<...
Exisulind in Preventing Polyps in Patients With Familial Adenomatous Polyposis - Tabular View - ClinicalTrials.gov
Catenins - Oxford Reference
The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase
Two Novel Somatic Mutations in Exon 15 of the Adenomatous Polyposis
Coli Gene in Iranian Familial Adenomatousis Polyposis Coli...
Plus it
Toll-like receptors (TLRs)/NF-B activation activated by lipopolysaccharide (LPS) was connected with - Transmembrane Wnt...
ASMscience | Use of Molecular Biology
Familial adenomatous polyposis (FAP) - Genetic conditions and inherited cancers - Macmillan Cancer Support
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
Celecoxib Approved as Adjunct for Patients With Familial Adenomatous Polyposis | Cancer Network | The Oncology Journal
E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice - MDC Repository
ReP USP - Detalhe do registro: Adenocarcinoma after ileoanal anastomosis for familial adenomatous polyposis: review of risk...
DMOZ - Health: Conditions and Diseases: Digestive System Disorders: Intestinal: Familial Adenomatous Polyposis
List of Familial Adenomatous Polyposis Medications (4 Compared) - Drugs.com
Familial Adenomatous Polyposis | Memorial Hospital
Adenomatous polyposis coli (IPR026836) | InterPro | EMBL-EBI
Lap Surgeon: July 2011
RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells<...
Identification and in vivo role of the Armadillo-Legless interaction | Development
LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin...
Intracellular shuttling of a Drosophila APC tumour suppressor homolog | BMC Cell Biology | Full Text
Ruxolitinib - Overcoming Resistance to HER2 Inhibitors
Synthetases, Other - Structure of Rhomboid Protease in Complex with β-Lactam Inhibitors
APC2 links ARMs to organise actin | Journal of Cell Science
colonoscopy | healthPlexus.net
Pharos : Target Details - O95996
The Paracrine Hormone for the GUCY2C Tumor Suppressor, Guanylin, Is Universally Lost in Colorectal Cancer | Cancer Epidemiology...
A Study of Rofecoxib in Familial Adenomatous Polyposis (FAP) (0966-205)(TERMINATED) - Full Text View - ClinicalTrials.gov
Deep intronic APC mutations explain a substantial proportion of patients with familial or early-onset adenomatous polyposis. -...
JoVE Author Search: Bothwell AL
RCSB PDB
for 4G69
PDB 1jpp structure summary ‹ Protein Data Bank in Europe (PDBe) ‹ EMBL-EBI
Researchers discover genetic mutation causing rare colorectal disorder in Gujarati family - BioVoiceNews
Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation...
APC Protein Connected to Autism and Mental Retardation
Family history
Getting blood in the stool. Done with sigmadoscopy. What are the findings?
BUB1B
"A role for the Adenomatous Polyposis Coli protein in chromosome segregation". Nature Cell Biology. 3 (4): 429-432. doi:10.1038/ ... The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/ ... BubR1 protein levels are shown to decline with age. Furthermore, loss of BubR1 in young organisms is associated with rapid ... Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene. Also ...
BUB3
"A role for the Adenomatous Polyposis Coli protein in chromosome segregation". Nature Cell Biology. 3 (4): 429-32. doi:10.1038/ ... Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene. Bub3 is a protein involved with the ... cancer adenomatous polyposis osteosarcoma familial breast cancer glioblastoma cervicitis lung cancer carcinoma Coli polyposis ... The complex of proteins which regulate the cell arrest are BUB1, BUB2, BUB3 (this protein), Mad1, Mad2, Mad3 and MPS1. At ...
Catenin beta-1
Through its N-terminal regulator of G-protein signaling (RGS) domain, it recruits the adenomatous polyposis coli (APC) protein ... and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore, ... its partner the Adenomatous Polyposis Coli (APC) protein contains 11 such motifs in tandem arrangement per protomer, thus ... "Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein". Proceedings of the National ...
CSNK2B
"Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein". Proc. Natl. Acad. Sci. U.S.A. ... "Characterization of protein interaction among subunits of protein kinase CKII in vivo and in vitro". Mol. Cells. KOREA. 8 (1): ... "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Mol. Cells. Korea (South). 12 ... a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2". J. Biol. Chem. UNITED STATES. ...
Casein kinase 2, alpha 1
"Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein". Proc. Natl. Acad. Sci. U.S.A. 99 ... Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as ... Kim MS, Lee YT, Kim JM, Cha JY, Bae YS (February 1998). "Characterization of protein interaction among subunits of protein ... Allende JE, Allende CC (1995). "Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling ...
DVL1
Rubinfeld B, Tice DA, Polakis P (2001). "Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by ... Segment polarity protein dishevelled homolog DVL-1 is a protein that in humans is encoded by the DVL1 gene. DVL1, the human ... Fagotto F, Jho Eh, Zeng L, Kurth T, Joos T, Kaufmann C, Costantini F (1999). "Domains of axin involved in protein-protein ... Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A (1999). "DIX domains of Dvl and axin are necessary for protein ...
AXIN1
Rubinfeld B, Tice DA, Polakis P (2001). "Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by ... The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein) beta 1, glycogen synthase ... Adenomatous polyposis coli, CREB-binding protein/(CBP) and might be affected in similar ways by missense mutations of their ... "GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein ...
MAPRE2
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene ... "The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules". Proc. Natl. Acad. ... a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells ... Microtubule-associated protein RP/EB family member 2 is a protein that in humans is encoded by the MAPRE2 gene. ...
MAPRE1
The protein encoded by this gene was first identified by its binding to the APC (Adenomatous polyposis coli) protein which is ... "The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules". Proc. Natl. Acad. ... which is why EB1 is categorized as a microtubule plus end tracking protein(+TIP protein). The protein also associates with ... Microtubule-associated protein RP/EB family member 1 is a protein that in humans is encoded by the MAPRE1 gene. ...
Inke Nathke
She is known for her work on the role of the adenomatous polyposis coli (APC) protein in colorectal cancer. Näthke grew up in ... Penman, George A.; Leung, Louie; Näthke, Inke S. (2005-10-15). "The adenomatous polyposis coli protein (APC) exists in two ... "The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration". ... In her postdoctoral work she established a link between the adenomatous polyposis coli (APC) tumor suppressor and cell movement ...
SIAH1
"Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein". Molecular Cell ... The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The ... October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. ... E3 ubiquitin-protein ligase SIAH1 is an enzyme that in humans is encoded by the SIAH1 gene. This gene encodes for a polypeptide ...
Aster (cell biology)
It is also dependent on several microtubule-associated proteins such as EB1 and adenomatous polyposis coli (APC). Growth of ... Cortical Dynein, a motor protein moves along the microtubules of the cell and plays a key role in the growth and inhibition of ...
XPO1
... of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance ... XPO1 mediates NES-dependent protein transport. It exports several hundreds of different proteins from the nucleus. XPO1 is ... "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export". J. Cell Biol. 153 (7): 1391-402. doi:10.1083/jcb ... is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs. XPO1 (CRM1) originally was identified in ...
TUBA4A
Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS (Jan 2001). "Binding of the adenomatous polyposis coli protein to microtubules ... Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4A gene. Microtubules of the eukaryotic cytoskeleton ... Kirsch J, Langosch D, Prior P, Littauer UZ, Schmitt B, Betz H (Nov 1991). "The 93-kDa glycine receptor-associated protein binds ... Huby RD, Carlile GW, Ley SC (Dec 1995). "Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, ...
DHRS9
2004). "The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol ... 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and ... transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMC 403697. PMID ...
Plakoglobin
... and scaffold proteins adenomatous polyposis coli (APC) and axin targets plakoglobin for degradation.[31-33]. The phosphorylated ... "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha- ... "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha- ... Swope D, Cheng L, Gao E, Li J, Radice GL (Mar 2012). "Loss of cadherin-binding proteins β-catenin and plakoglobin in the heart ...
PPP2R5A
"ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein ... "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2-3): 197-201. doi: ... "The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein ... Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell ...
Cadherin-1
"The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha- ... Cadherin-1 or Epithelial cadherin (E-cadherin), (not to be confused with the APC/C activator protein CDH1) is a protein that in ... Complete loss of E-cadherin protein expression in 84% of lobular breast carcinomas. Several proteins such as SNAI1/SNAIL, ... CDH1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) GeneReviews/NCBI/NIH/UW entry on ...
Catenin alpha-1
"The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha- ... "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha- ... Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction ... "Entrez Gene: CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa". "Protein sequence of human CTNNA1 (Uniprot ID: ...
Viji Draviam
She showed that checkpoint proteins have to 'sense' that both the adenomatous polyposis coli and EB1 proteins to support normal ... but not clear why aneuploidy can still occur in cells with checkpoint proteins. Draviam demonstrated that checkpoint proteins ... Dravian, Viji Mythily; Raff, Jordan W (2003). "The ch-TOG/XMAP215 protein is essential for spindle pole organization in human ... They study kinetochore proteins through selective mutations and investigations using single molecule microscopy. Specifically, ...
TFAP2A
Li Q, Dashwood RH (Oct 2004). "Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits ... Transcription factor AP-2 alpha (Activating enhancer binding Protein 2 alpha), also known as TFAP2A, is a protein that in ... "The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module". ... "Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic ...
MiR-27
... has been found to target and inhibit gene expression of the adenomatous polyposis coli (APC) protein, enabling it to ... FOXO1 protein expression is down-regulated in breast tumour tissue samples; miR-27a has been identified as one of three miRNAS ... There is activation of Wnt signalling through nuclear accumulation of this protein, which is in response to inhibition of the ... Suppression of miR-27a results in a FOXO1 protein increase and a consequent cell number decrease. Landgraf, P; Rusu, M; ...
P120 (protein)
"The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha- ... "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha- ... p120, and called catenin delta-1 is a protein that in humans is encoded by the CTNND1 gene. This gene encodes a member of the ... The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141-50. ...
Ran (protein)
... of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance ... Ran (RAs-related Nuclear protein) also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the ... Ran is a small G protein that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran ... "Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import ...
Microtubule
This later activity is mediated by formins, the adenomatous polyposis coli protein, and EB1, a protein that tracks along the ... MAP-1 proteins consists of a set of three different proteins: A, B and C. The C protein plays an important role in the ... including the motor proteins dynein and kinesin, microtubule-severing proteins like katanin, and other proteins important for ... Plus end tracking proteins are MAP proteins which bind to the tips of growing microtubules and play an important role in ...
Gardner fibroma
This gene encodes (i.e. directs production of) the adenomatous polyposis coli protein (APC protein) but when mutated in FAP ... In the majority of cases, GF tumors are manifestations of the genetic disease, familial adenomatous polyposis (FAP), or its ... APC protein acts indirectly to degrade β-catenin, a protein which when overexpressed induces various cancers. Partially or ... "Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations". Archives of Pathology & ...
PPP2R5B
"GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein ... "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2-3): 197-201. doi: ... Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell ... Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the ...
PPP2R5C
"GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein ... The product of this gene belongs to the Protein phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of ... "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2-3): 197-201. doi: ... Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the ...
Kinesin-associated protein 3
2006). "Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus". PLOS Genet. 2 (9): e146. doi: ... Kinesin-associated protein 3 (KAP3) is a protein that in humans is encoded by the KIFAP3 gene. It is a non-motor, accessory ... The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G ... The protein encoded by this gene contains 9 Armadillo repeats and interacts with the smg GDS protein through these repeats. ...
APC
... an anti-coagulant and anti-inflammatory protein Adenomatous polyposis coli, a tumor suppressor protein encoded by the APC gene ... a family of transport proteins APC Superfamily, a superfamily of transport proteins APC tablet, analgesic compound of aspirin, ... a protein from the light-harvesting phycobiliprotein family Allylpalladium chloride dimer, a chemical compound Ammonium ... mutations in which can cause colon cancer Anaphase-promoting complex, a ubiquitin ligase cell cycle protein Antigen-presenting ...
PSMD7
Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in ... To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special ... Accordingly, misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; ... The 19S regulatory particles can recognize ubiquitin-labeled protein as degradation substrate, unfold the protein to linear, ...
PSMB3
Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in ... The eukaryotic proteasome recognizes degradable proteins, including damaged proteins for protein quality control purpose or key ... "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". ... This protein is one of the 17 essential subunits that contribute to the complete assembly of the 20S proteasome complex. In ...
Ubiquitin
The gene associated with colorectal cancer is the adenomatous polyposis coli (APC), which is a classic tumor suppressor gene. ... coordinating the cellular localization of proteins, activating and inactivating proteins, and modulating protein-protein ... The protein modifications can be either a single ubiquitin protein (monoubiquitylation) or a chain of ubiquitin ( ... The monoubiquitination of a protein can have different effects to the polyubiquitination of the same protein. The addition of a ...
APC internal ribosome entry site (IRES)
APC is a tumour suppressor gene which is associated with the inherited disease adenomatous polyposis coli (APC). It is thought ... Heppner Goss K, Trzepacz C, Tuohy TM, Groden J (June 2002). "Attenuated APC alleles produce functional protein from internal ...
PSMD5
Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ... Lecossier D, Bouchonnet F, Clavel F, Hance AJ (2003). "Hypermutation of HIV-1 DNA in the absence of the Vif protein". Science. ... Such protein accumulation may contribute to the pathogenesis and phenotypic characteristics in neurodegenerative diseases, ...
LGR5
... such as formation of adenoma via Adenomatous polyposis coli (APC) mutation. Studies on LGR5 in colorectal cancer revealed a ... is a protein that in humans is encoded by the LGR5 gene. It is a member of GPCR class A receptor proteins. R-spondin proteins ... Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) also known as G-protein coupled receptor 49 (GPR49) or G- ... "LGR5 leucine-rich repeat-containing G protein-coupled receptor 5". Entrez Gene. "LGR5 leucine-rich repeat containing G protein- ...
PSMD14
Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in ... Misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; in addition, ... To recognize proteins as designated substrates, the 19S complex has subunits that are capable of recognizing proteins with a ... The 19S regulatory particles can recognize ubiquitin-labeled protein as a substrate for degradation, unfold the protein to a ...
List of OMIM disorder codes
PLAG1 Adenomatous polyposis coli; 175100; APC Adenosine deaminase deficiency, partial; 102700; ADA Adenosine triphosphate, ... HRG Thrombophilia due to protein C deficiency, autosomal dominant; 176860; PROC Thrombophilia due to protein C deficiency, ... GPR56 Polyposis syndrome, hereditary mixed, 2; 610069; BMPR1A Polyposis, juvenile intestinal; 174900; BMPR1A Polyposis, ... OPN1SW Colorectal adenomatous polyposis, autosomal recessive, with pilomatricomas; 132600; MUTYH Colorectal cancer; 114500; ...
PSMA3
Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in ... The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key ... "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ... "The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins". Nature Cell Biology. 3 (1): 93-6. ...
Missense mRNA
Muniappan BP, Thilly WG (June 2002). "The DNA polymerase beta replication error spectrum in the adenomatous polyposis coli gene ... An amino acid change may not result in appreciable changes in protein structure depending on whether the amino acid change is ... "Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both ... and confer transcriptome diversity and enhanced protein function in response to selective pressures. Nonsense mutation Start ...
PSMB10
Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in ... The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key ... This protein has a major role in the immune system as part of an immunoproteasome that is primarily induced upon infection and ... The human protein proteasome subunit beta type-8 is 25 kDa in size and composed of 234 amino acids. The calculated theoretical ...
PSMD1
Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in ... To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special ... Accordingly, misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; ... The 19S regulatory particles can recognize ubiquitin-labeled protein as degradation substrate, unfold the protein to linear, ...
L. S. Shashidhara
... and EGFR/Ras that impact the growth control and developed a fly model for studying Adenomatous polyposis coli, the colon cancer ... Development (doi: 10.1242/dev.161844). Shukla, J.P., Deshpande, G. and Shashidhara, L.S. (2017). Ataxin-2 binding protein 1 is ... Drosophila melanogaster Homeotic selector gene Adenomatous polyposis coli Ultrabithorax India portal Biology portal 25 of his ... "ChIP for Hox Proteins from Drosophila Imaginal Discs". Hox Genes. Methods in Molecular Biology. Vol. 1196. pp. 241-253. doi: ...
PSMD8
Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in ... Li T, Duan W, Yang H, Lee MK, Bte Mustafa F, Lee BH, Teo TS (Jan 2001). "Identification of two proteins, S14 and UIP1, that ... Lecossier D, Bouchonnet F, Clavel F, Hance AJ (May 2003). "Hypermutation of HIV-1 DNA in the absence of the Vif protein". ... Such protein accumulation may contribute to the pathogenesis and phenotypic characteristics in neurodegenerative diseases, ...
Naked cuticle 1
... the majority of which have increased Wnt signaling due to mutations the adenomatous polyposis coli (APC), AXIN2, or rarely the ... Naked cuticle 1 (NKD1) is a human gene that encodes the protein Nkd1, a member of the Naked cuticle (Nkd) family of proteins ... Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev Biol. 2001 Jun 1;234 ... family of proteins (DVL1, DVL2, DVL3). Specific truncating NKD1 mutations identified in DNA mismatch repair deficient colon ...
CTNNBIP1
2009). "Somatic mutations of adenomatous polyposis coli gene and nuclear b-catenin accumulation have prognostic significance in ... Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene. The protein encoded by this ... 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli". J ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
FAM203B
... and adenomatous polyposis coli in mammals. DUF383: Domain of unknown function 383 DUF384: Domain of unknown function 383 Every ... "Predicted: brain protein 16-like [Danio rerio]". NCBI Protein. Retrieved 5 February 2013. "Predicted: brain protein 16-like [ ... BRP16 (brain protein 16) is an alias of FAM203A, and BRP16L (brain protein 16-like) is an alias of FAM203B. A gene named BRP16L ... The BRP16L protein in D. rerio has a significant 3' truncation compared to the M. mulatta protein, further supporting the ...
Wnt signaling pathway
This destruction complex includes the following proteins: Axin, adenomatosis polyposis coli (APC), protein phosphatase 2A (PP2A ... Minde DP, Radli M, Forneris F, Maurice MM, Rüdiger SG (2013). "Large extent of disorder in Adenomatous Polyposis Coli offers a ... "Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations". PLOS ... Dsh proteins are present in all organisms and they all share the following highly conserved protein domains: an amino-terminal ...
PSMD9
Moreover, the UPS regulates the degradation of tumor suppressor gene products such as adenomatous polyposis coli (APC) in ... The PSMA5 protein has further been associated with the biosynthesis of conjugated linoleic acid (CLA) in mammary tissue. GRCh38 ... Lecossier D, Bouchonnet F, Clavel F, Hance AJ (May 2003). "Hypermutation of HIV-1 DNA in the absence of the Vif protein". ... Such protein accumulation may contribute to the pathogenesis and phenotypic characteristics in neurodegenerative diseases, ...
Chromosome 5
... encoding protein Amyloid beta A4 precursor protein-binding family B member 3 APC: adenomatosis polyposis coli ARL15: encoding ... Familial Adenomatous Polyposis is caused by a deletion of the APC tumor suppressor gene on the long (q) arm of chromosome 5. ... encoding protein Proline-rich protein 16 PURA: Purine-rich element-binding protein A PWWP2A: encoding protein PWWP domain ... Protein Red IRX1: Iroquois-class homeodomain protein (human) LARP1: La-related protein 1 LMAN2: Lectin mannose binding 2 LNCR3 ...
APC gene: MedlinePlus Genetics
The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes. Learn ... The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium. Annu Rev Cell Dev Biol. 2004;20:337-66. doi: ... Goss KH, Groden J. Biology of the adenomatous polyposis coli tumor suppressor. J Clin Oncol. 2000 May;18(9):1967-79. doi: ... Senda T, Shimomura A, Iizuka-Kogo A. Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene. Anat Sci ...
Adenomatous polyposis coli - Wikipedia
Adenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the ... The (Adenomatous Polyposis Coli) APC protein normally builds a "destruction complex" with glycogen synthase kinase 3-alpha and ... Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS (January 2001). "Binding of the adenomatous polyposis coli protein to microtubules ... Li Q, Dashwood RH (October 2004). "Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and ...
SAPCD2 suppressor APC domain containing 2 [Homo sapiens (human)] - Gene - NCBI
Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein. Alternate T2T-CHM13v2.0. Genomic * NC_060933.1 Alternate ... General protein information Go to the top of the page Help Preferred Names. suppressor APC domain-containing protein 2. Names. ... mRNA and Protein(s) * XM_011519180.4 → XP_011517482.1 suppressor APC domain-containing protein 2 isoform X1 ... mRNA and Protein(s) * NM_178448.4 → NP_848543.2 suppressor APC domain-containing protein 2 ...
DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95
DAP-1 was found to associate with hDLG, PSD-95, NMDA-R and adenomatous polyposis coli protein (APC). Furthermore, we found that ... Background: The human homologue of the Drosophila discs large tumour suppressor protein (hDLG) and closely related proteins ... DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95 Genes Cells. 1997 Jun;2(6):415- ... Results: We have identified a protein named DAP-1 that binds to the guanylate kinase-like domains of hDLG and PSD-95. ...
Identification of sister chromatids by DNA template strand sequences | Nature
Hanson, C. A. & Miller, J. R. Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein. Gene 361 ... A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nature Cell Biol. 3, 429-432 (2001) ... Etienne-Manneville, S. & Hall, A. Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity. Nature 421, ... Kita, K., Wittmann, T., Nathke, I. S. & Waterman-Storer, C. M. Adenomatous polyposis coli on microtubule plus ends in cell ...
Oral Submucous Fibrosis Treatment & Management: Medical Care, Surgical Care, Consultations
Biblio | Page 3 | Linus Pauling Institute | Oregon State University
SCOPe 2.08: Structural Classification of Proteins - extended
... and ASTRAL compendium for protein structure and sequence analysis ... adenomatous polyposis coli protein. Species: Homo sapiens [ ... Compound: Beta-catenin-interacting protein 1. Species: Homo sapiens [TaxId:9606]. Gene: CTNNBIP1,ICAT. Database cross- ... SCOPe: Structural Classification of Proteins - extended. Release 2.08 (updated 2022-09-21, stable release September 2021) ...
Woo-Yang Kim | Semantic Scholar
Plus it
2004) Neuronal nicotinic synapse assembly requires the adenomatous polyposis coli tumor suppressor protein. J Neurosci 24:6776- ... 2008) Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic ... 2007) Wnt-7a induces presynaptic colocalization of α7-nicotinic acetylcholine receptors and adenomatous polyposis coli in ... Green fluorescent protein (GFP) fusion proteins for SAP102, SAP97, and PSD-93 (SAP102-GFP, SAP97-GFP, and PSD-93-GFP, ...
Frontiers | Dendritic Actin Cytoskeleton: Structure, Functions, and Regulations
... and the role of F-actin in dendritic protein trafficking. ... and the role of F-actin in dendritic protein trafficking. ... Actin is a versatile and ubiquitous cytoskeletal protein that plays a major role in both the establishment and the maintenance ... Actin is a versatile and ubiquitous cytoskeletal protein that plays a major role in both the establishment and the maintenance ... 2010). Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. J. Cell Biol. 189, ...
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex | Nature
These data highlight a dual role for DISC1 in corticogenesis and indicate that phosphorylation of this protein at S710 ... proteins to the centrosome. In support of this model, loss of BBS1 leads to defects in migration, but not proliferation, ... The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral ... Figure 1: Phosphorylation of DISC1 at S710 selectively increases binding of DISC1 with BBS proteins, resulting in enhanced BBS1 ...
SET/TAF-I Antibodies
Dikovskaya, Khoudoli, Newton, Chadha, Klotz, Visvanathan, Lamond, Swedlow, Näthke: "The adenomatous polyposis coli protein ... The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits ... The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This ... This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms ...
WikiGenes - Embryonic Induction
The cadherin-catenin complex is expressed alternately with the adenomatous polyposis coli protein during rat incisor ... Antibodies to extracellular matrix proteins were also studied to determine the temporal sequence between expression of ... immunoreactive protein for basement membrane proteins, which serve as markers of embryonic induction of nephron development, ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ...
SMART: Schnipsel domain ARM
... and include such proteins as beta-catenin, the junctional plaque protein plakoglobin, the adenomatous polyposis coli (APC) ... The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling. ... Crystal structure of the complex between the armadillo repeat domain of adenomatous polyposis coli and the tyrosine-rich domain ... The Structure of a beta-Catenin Binding Repeat from Adenomatous Polyposis Coli (APC) in Complex with beta-Catenin. ...
Chapter 13 | HuGE 2010 | CDC
The adenomatous polyposis coli (APC) gene is a tumor suppressor gene, and mutations resulting in loss of APC protein function ... Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia. Med Mol Morphol. 2007;40:68- ... autosomal dominant neoplastic syndrome of Familial Adenomatous Polyposis Coli (FAP). This condition has an annual incidence of ... Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N Engl J Med. 2003;348:791-799. ...
H. Joseph Yost - Google Scholar
Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. J Liu, J Stevens, ... Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. X Li, HJ Yost, DM Virshup, JM Seeling ... RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis. HJ Yost, S Lindquist ...
CDH1 (gene) - wikidoc
"The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha- ... Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction ... Several proteins such as SNAI1/SNAIL,[54][55] ZFHX1B/SIP1,[56] SNAI2/SLUG,[57][58] TWIST1[59] and DeltaEF1[60] have been found ... Cadherin-1 also known as CAM 120/80 or epithelial cadherin (E-cadherin) or uvomorulin is a protein that in humans is encoded by ...
Cancer | The Scientist Magazine®
Following protein pathways can lead to unexpected places. In this case, three groups approached b-catenin from separate d ... Kinzlers group at Johns Hopkins University independently reported that the tumor suppressor protein adenomatous polyposis coli ... Following protein pathways can lead to unexpected places. In this case, three groups approached b-catenin from separate d. The ... Following protein pathways can lead to unexpected places. In this case, three groups approached b-catenin from separate ...
Genetik der kortikalen Fehlbildungen - Deutsch
Biblio | Page 30 | Linus Pauling Institute | Oregon State University
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor ... Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor ... Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor ... Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor ...
Reactome | APC E1544* [cytosol]
Find Research outputs - University of Huddersfield Research Portal
Reactome | APC R499* [cytosol]
Hypothalamic beta-endorphin neurons suppress preneoplastic and neoplastic lesions development in 1,2-dimethylhydrazine induced...
Alterations of beta-catenin expression, and its binding partners E-cadherin and the adenomatous polyposis coli protein (APC), ... in addition to its binding partners E-cadherin and the adenomatous polyposis coli protein (APC), are frequent events in ... Effects of BEP neuron transplants in the hypothalamus on DMH-induced changes in EMT marker proteins levels in the colon. (A-D) ... Effects of BEP neuron transplants in the hypothalamus on DMH-induced changes in NK cell cytolytic proteins levels in the colon ...
Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification<...
... alterations in intracellular signal transduction proteins (Adenomatous polyposis coli, β-catenin), causing constitutive pathway ... alterations in intracellular signal transduction proteins (Adenomatous polyposis coli, β-catenin), causing constitutive pathway ... alterations in intracellular signal transduction proteins (Adenomatous polyposis coli, β-catenin), causing constitutive pathway ... alterations in intracellular signal transduction proteins (Adenomatous polyposis coli, β-catenin), causing constitutive pathway ...
Search Results
"Chondrogenic induction by bone morphogenetic protein-2: Involvement of" by Andrew Robert Haas
... and that the protein adenomatous polyposis coli (APC) may play a role in regulating these interactions. The research presented ... This thesis research investigates the regulation of N-cadherin-dependent cell adhesion by bone morphogenetic protein-2 (BMP-2) ... BMP-2 upregulation of N-cadherin expression and resultant chondrogenesis required mitogsn activated protein kinase (MAPK) ... and by day 5 an 8-fold upregulation of N-cadherin protein. ... and that the protein adenomatous polyposis coli (APC) may play ...
Target identification in Fusobacterium nucleatum by subtractive genomics approach and enrichment analysis of host-pathogen...
... through subtractive genomics approach and host-pathogen protein-protein interactions (HP-PPIs). We also carried out enrichment ... Hence, proteins from IBDsite, a database for inflammatory bowel disease (IBD) research and those involved in colorectal ... These target proteins might be considered for designing potent inhibitors to abrogate F. nucleatum infections. From enrichment ... Subtractive genomics analysis provided a set of target proteins suggested to be indispensable for survival and pathogenicity of ...
Post-Translational Modifications Of Β-Catenin And TCF/LEF-1 Regulate Canonical Wnt Signaling
... in beta-catenins role as a co-transcriptional factor with the DNA binding proteins TCF (T cell factor) and LEF-1 (lymphoid ... a multi-protein destruction complex consisting of the scaffolding/tumor suppressor proteins Axin and adenomatous polyposis coli ... The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr. Biol. 9, ... The E3 ligase NLK-associated Ring Finger Protein (NARF) ubiquitinates TCF/LEF-1 in vitro and in vivo, which leads to TCF/LEF-1 ...
FamilialMutationsAxinGenesSignaling pathwayActinPolypsSignal transductionColon cancerKinaseDP2.5SyndromesCateninPhosphorylationCytoskeletonMicrotubulesDegradationTumour suppressor proteinAssociation domain family 1ARegulatesTumorsReceptorsPMIDEscherichiaBindsCadherinInactivationHereditaryMembraneRegulationApoptosisCytoplasmicAntibodiesPathwaysMetabolismAPC2GeneticCellsFamily of proteinsScaffold proteinIntestinalMutation cluster regionInteractionsExtracellular matrix pMiceAmino AcidInhibitsPolyclonal
Familial24
- Familial adenomatous polyposis (FAP) is caused by an inherited, inactivating mutation in the APC gene. (wikipedia.org)
- More than 800 mutations[citation needed]in the APC gene have been identified in families with classic and attenuated types of familial adenomatous polyposis. (wikipedia.org)
- The most common mutation in familial adenomatous polyposis is a deletion of five bases in the APC gene. (wikipedia.org)
- Although APC -related desmoid tumors are commonly associated with a form of colon cancer called familial adenomatous polyposis (described below), APC gene mutations can cause tumors in individuals without this inherited disease. (medlineplus.gov)
- Mutations in the APC gene are also responsible for a disorder called Turcot syndrome, which is closely related to familial adenomatous polyposis. (medlineplus.gov)
- Intra-abdominal DTs are often observed in patients with an association of familial adenomatous polyposis (FAP) or Gardner syndrome (see these terms). (rarehematologynews.com)
- The observed variant frequency is approximately 2 fold of the estimated maximal expected allele frequency for a pathogenic variant in APC causing Familial Adenomatous Polyposis phenotype (7.1e-05), strongly suggesting that the variant is benign. (utah.edu)
- A has been reported in the literature in individuals affected with Familial Adenomatous Polyposis, colorectal cancer, HBOC, ALL and Neuroblastoma (e.g. (utah.edu)
- These reports do not provide unequivocal conclusions about association of the variant with Familial Adenomatous Polyposis. (utah.edu)
- The adenomatous polyposis coli (APC) gene was analyzed for germline mutations in 113 familial adenomatous polyposis suspected families from all over Slovakia. (nel.edu)
- In the case of multiple intestinal polyps associated with familial adenomatous polyposis (FAP), colon resection remains the only feasible option (see the image below). (medscape.com)
- Familial adenomatous polyposis, total colectomy specimen. (medscape.com)
- We further showed that DIM was able to down-regulate survivin and enhance the effects of butyrate in apoptosis induction and prevention of familial adenomatous polyposis in APC min/+ mice. (scialert.net)
- Adenomatous polyposis coli (APC) is a gene whose mutations are associated with a rare, hereditary form of colorectal cancer known as familial adenomatous. (pasteur.fr)
- Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases. (snpedia.com)
- APC gene mutations in Chinese familial adenomatous polyposis patients. (snpedia.com)
- Combined with the continuing progress for our novel Ribosome Modulating Agents in RDEB and familial adenomatous polyposis, we believe we are poised to deliver on multiple potential value-creating events over the next twelve months. (eloxxpharma.com)
- Not all polyposis syndromes are familial. (medscape.com)
- Familial polyposis syndromes are divided into 2 major groups based on the presence of adenomas or hamartomas. (medscape.com)
- the familial hamartomatous polyposis syndromes include Peutz-Jeghers syndrome and juvenile polyposis. (medscape.com)
- Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria. (vanderbilt.edu)
- The analysis from the molecular bases of two main syndromes familial adenomatous polyposis (FAP) and hereditary nonpolypsis CRC (HNPCC) provides resulted in the id of two primary pathways where these molecular occasions can result in CRC [5]. (flora2world.com)
- Hereditary Nonpolyposis Colorectal Cancer (HNPCC) and Familial Adenomatous Polyposis (FAP) are the two most common forms of hereditary predisposition to colorectal cancer. (vallhebron.com)
- In patients with familial adenomatous polyposis, a genetic disease predisposing to colon cancer, mutations of the APC gene induce the formation of intestinal polyps, but. (newzs.de)
Mutations16
- Most of these mutations cause the production of an APC protein that is abnormally short and presumably nonfunctional. (wikipedia.org)
- Most APC gene mutations that cause sporadic desmoid tumors lead to an abnormally short APC protein. (medlineplus.gov)
- Most of these mutations lead to the production of an abnormally short, nonfunctional version of the APC protein. (medlineplus.gov)
- The adenomatous polyposis coli ( APC ) gene is a tumor suppressor gene, and mutations resulting in loss of APC protein function are associated with carcinogenesis. (cdc.gov)
- Wnt-activating mutations can be divided into: i) ligand-independent (LI) alterations in intracellular signal transduction proteins (Adenomatous polyposis coli, β-catenin), causing constitutive pathway activation and ii) ligand-dependent (LD) mutations affecting the synergistic R-Spondin axis (RNF43, RSPO-fusions) acting through amplification of endogenous Wnt signal transmembrane transduction. (elsevier.com)
- To evaluate the role of the APC/beta-catenin/Tcf pathway, we analyzed mutations in the beta-catenin gene and the accumulation of beta-catenin protein in gastric carcinomas. (springernature.com)
- Our findings suggest that somatic mutations of the beta-catenin gene are rare in human gastric carcinomas and that accumulation of normal beta-catenin protein in a subset of gastric cancers may be due to other mechanisms of its activation. (springernature.com)
- In cases with FAP, DTs have been associated with mutations in the tumor suppressor gene APC (5q21-q22) encoding the adenomatous polyposis coli protein . (rarehematologynews.com)
- In 64 urothelial carcinomas of the urinary bladder, methylationspecific polymerase chain reaction with RAS association domain family 1A (RASSF1A), adenomatous polyposis coli (APC), death-associated protein-kinase (DAPK), runt-related transcription factor 3 (RUNX3), p14, p16 and MGMT was performed and correlated the results with p53 mutations, DNA ploidy, clinicopathologic parameters and recurrences. (jpatholtm.org)
- Colorectal cancer (CRC) is categorized by alteration of vital pathways such as β-catenin (CTNNB1 ) mutations, WNT signaling activation , tumor protein 53 ( TP53 ) inactivation, BRAF , Adenomatous polyposis coli ( APC ) inactivation, KRAS , dysregulation of epithelial to mesenchymal transition ( EMT ) genes, MYC amplification, etc. (biomedcentral.com)
- We recently showed that mutations in the adenomatous polyposis coli ( APC ) gene confer resistance to HDAC inhibitor-induced apoptosis in colon cancers. (scialert.net)
- We used the C10 cell line, which we established and have previously shown to lack adenomatous polyposis coli, E-cadherin, or beta-catenin mutations. (ox.ac.uk)
- Regardless the importance of GST activity for cellular vitality and health, the GST gene cluster is a hotspot for DNA sequence mutations that leads to the expression of active but functionally different GST variant proteins. (frontiersin.org)
- ZKN-013 continues to demonstrate dose dependent inducement of functional Collagen VIIA protein (truncated in patients with nonsense mutations patients), in RDEB patient cells. (eloxxpharma.com)
- The majority of CRC is induced by mutations in adenomatous polyposis coli (transcription followed by metal-induced hydrolysis at 94C. (scienceonstageturkey.com)
- Unlike HPV-negative HNSCC that is driven by the stepwise accumulation ofmutations in the squamous epithelium, notably mutations in the p53 tumor suppressor gene,HPV-positive HNSCC is caused by two viral oncogenes encoding for early viral proteins, E6 and E7, that bind and inactivate the tumor suppressor genes p53 and pRb leading to malignant transformation of the squamous epithelium. (a-inhibitor.com)
Axin15
- The (Adenomatous Polyposis Coli) APC protein normally builds a "destruction complex" with glycogen synthase kinase 3-alpha and or beta (GSK-3α/β) and axin via interactions with the 20 AA and SAMP repeats. (wikipedia.org)
- APC protein down-regulates the Wnt signaling pathway through its binding to β-catenin and axin ( 8 ). (cdc.gov)
- In the absence of Wnt binding to the co-receptor complex of Frizzled (Fz) and low-density lipoprotein receptor-related proteins (LRP) 5 and 6, a multi-protein destruction complex consisting of the scaffolding/tumor suppressor proteins Axin and adenomatous polyposis coli (APC), and the serine/threonine kinases casein kinase 1α (CK-1α) and glycogen synthase kinase 3 (GSK3) mediates phosphorylation of β-catenin 2,3,9 . (cytoskeleton.com)
- PTHR23315: beta-catenin and the subtree to which beta-catenin belongs seems okay #PTHR10845:AN318: Axin #*Subfamily of the RGS (Regulators of G-protein signaling) # PTHR11309 frizzled: 7 distinct subfamilies #* Transmembrane proteins that are receptors for the Wnt signaling proteins. (geneontology.org)
- Axin Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- This graph shows the total number of publications written about "Axin Protein" by people in this website by year, and whether "Axin Protein" was a major or minor topic of these publications. (uchicago.edu)
- Below are the most recent publications written about "Axin Protein" by people in Profiles. (uchicago.edu)
- In the absence of a mitotic signal from outside the cell, β-catenin is sequestered in a complex with the adenomatous polyposis coli (APC) gene product, a serine threonine glycogen synthetase kinase (GSK-3β) and an adapter protein axin (or a homologue conductin), enabling phosphorylation and degradation of free β-catenin by the ubiquitin-proteasome system [ 8 ]. (biomedcentral.com)
- Activation of DsH inhibits another complicated of cytoplasmic proteins including axin, GSK-3 (glycogen synthase kinase-3), as well as the proteins APC (adenomatous polyposis coli). (sprentland.com)
- In the absence of Wnt signaling, free cytoplasmic β-catenin is rapidly targeted for degradation by a multiprotein complex containing (i) the scaffold proteins axin and adenomatous polyposis coli (APC), and (ii) the serine/threonine kinases casein kinase 1 α (CK1α) and glycogen synthase kinase 3β (GSK3β) [ 10 , 11 ]. (scitechnol.com)
- DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. (modencode.org)
- GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin. (modencode.org)
- Intracellular -catenin amounts are controlled with a complicated made up of axin, casein kinase 1 (CKI)a, and adenomatous polyposis coli (APC). (uitest.info)
- The second reason is within the destruction complicated in cytoplasm, which is usually assembled from the scaffold protein AXIN, APC, GSK3, and CSNK1A1. (antiviralbiologic.com)
- In canonical Wnt/β-catenin signaling, the binding of Wnt to Fzd and LRP5/6 results in activation and phosphorylation of the latter, recruitment of Dishvelled and Axin proteins, and inhibition of glycogen synthase kinase (GSK)3β-mediated β-catenin phosphorylation and proteolytic degradation. (scirp.org)
Genes11
- It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
- In subtractive genomics approach, the essential, virulence and resistance related proteins were retrieved from RefSeq proteome of F. nucleatum by searching against Database of Essential Genes (DEG), Virulence Factor Database (VFDB) and Antibiotic Resistance Gene-ANNOTation (ARG-ANNOT) tool respectively. (biomedcentral.com)
- In canonical Wnt-mediated signaling, β-catenin is a key effector and interacts, as a co-transcription factor, with the DNA binding proteins TCF (T cell factor) and LEF-1 (lymphoid enhancer factor 1) to activate the transcription of Wnt/β-catenin target genes including cyclin D1, c-jun, and c-myc 8-11 (Fig. 1). (cytoskeleton.com)
- a downstream target of GSK3β Glycogen synthase kinase-3 (GSK-3) is a serine/threonine protein kinase encoded by two highly homologous and ubiquitously expressed genes. (web.app)
- Stabilized β-catenin accumulates in the nucleus where it binds to T cell factor/lymphoid enhancer factor (LEF) and regulates the expression of Snail, Twist, fibronectin, fibroblast-specific protein (FSP)1, matrix metalloproteinase (MMP)-7, plasminogen activator inhibitor (PAI)-1, Ras, and other target genes that promote EMT. (scirp.org)
- Loss of the APC protein prevents the turnover of p-catenin, and hence p-catenin accumulates in the nucleus and causes the activation of TCF/ LEF or Wnt target genes such as c-Myc and Cyclin D2 (Bienz and Clevers, 2000). (cyberleninka.org)
- GENEMANIA revealed five genes similar in their expression level with MSH6 and seven genes share the same protein domain with it. (sapub.org)
- The ras genes (H-, K- and N-) code for highly related proteins of 189 amino acid residues generically known as p21 [ 5 ]. (oeso.org)
- Genomic techniques such as DNA microarray analysis and proteomic methods such as two-dimensional (2-D) electrophoresis and mass spectrometry are now popular to elucidate the manifestation profiles of genes and proteins. (flora2world.com)
- 2014). Such hereditary amendments often involve activation of cell development signaling through mutation of aswell as through mutation or epigenetic silencing of vital tumor suppressor genes (TSGs) such as for example p53 and adenomatous polyposis coli (reasonably as dependant on microarray analysis, IFNprotein creation had not been noticeable by ELISA easily, because of low level appearance probably, which was likewise observed also in the FHC handles (Amount 1B). (labrador-kennel.com)
- Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). (lookformedical.com)
Signaling pathway7
- The activity of one protein in particular, beta-catenin, is controlled by the APC protein (see: Wnt signaling pathway). (wikipedia.org)
- Abstract: apc (adenomatous polyposis coli) protein has been thought to be involved in tumor suppression through the wnt/b-catenin signaling pathway. (queenscovecreative.com)
- Wingless-type MMTV (mouse mammary tumor pathogen) integration site category of the proteins (Wnt) signaling pathway is certainly among those pathways regulating cell proliferation. (sprentland.com)
- Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. (modencode.org)
- Smoothened (SMO) is one of the constituent proteins of the Hedgehog signaling pathway, and the Hedgehog protein family consists of sonic hedgehog (SHH), Indian hedgehog (IHH), and desert hedgehog (DHH), which bind to the cell surface as a transmembrane protein receptor, Patched (PTCH). (researchsquare.com)
- Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo. (cmu.edu)
- This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. (abnova.com)
Actin6
- Actin is a versatile and ubiquitous cytoskeletal protein that plays a major role in both the establishment and the maintenance of neuronal polarity. (frontiersin.org)
- In this review, we focus on recent developments regarding the role of actin in dendrite morphology, the regulation of actin dynamics by internal and external factors, and the role of F-actin in dendritic protein trafficking. (frontiersin.org)
- At the plasma membrane β-catenin is an important component of the adherens junctions and links cadherin adhesion proteins to the actin cytoskeleton. (scitechnol.com)
- Actin cables are assembled at the bud neck by the formin protein Bnr1, and rapidly extend into the mother cell at a rate of 0.5-1 µm/s. (brandeis.edu)
- In doing so, they identified a novel actin cable 'length sensing' feedback loop, dependent on the myosin-passenger protein Smy1. (brandeis.edu)
- Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions. (pasteur.fr)
Polyps7
- This short protein cannot suppress the cellular overgrowth that leads to the formation of polyps, which can become cancerous. (wikipedia.org)
- This short protein cannot suppress the cellular overgrowth that leads to the formation of abnormal growths (polyps) in the colon, which can become cancerous. (medlineplus.gov)
- Studies indicate that the majority of large adenomatous polyps in women will be missed by using flexible sigmoidoscopy alone. (medscape.com)
- Colonic polyps can occur as part of inherited polyposis syndromes in which their number is greater and the risk for malignant progression is much higher compared to the risk associated with isolated colonic polyps. (medscape.com)
- FAP is characterized by the presence of hundreds to thousands of adenomatous polyps in the colon and rectum of affected individuals and would lead to colorectal cancer in virtually all the patients if left untreated. (vallhebron.com)
- 11 Naveau et al found that alcoholism and cirrhosis were two independent risk factors for colorectal adenomatous polyps after successive adjustments for sex, age, smoking, and serum cholesterol levels. (bmj.com)
- Effects of oral calcium supplementation on intestinal bile acids and cytolytic activity of fecal water in patients with adenomatous polyps of the colon. (jamanetwork.com)
Signal transduction2
- Arrestins (abbreviated Arr) are a family of proteins which are important in the regulation of signal transduction G-protein coupled receptors, which at first was discovered, as part of a conserved two step mechanism for regulating the activity of G protein-coupled receptors (GPCR) in rhodopsin visual system by Ursula Kuhn found Scott court, and β-called Global Martin J. Lohse system and kidney and colleagues. (arrestins.com)
- Ras proteins bind GTP and GDP and possess intrinsic GTPase activity and are involved in signal transduction inducing manifestations of the malignant phenotype. (oeso.org)
Colon cancer4
- Colon cancer was induced by injecting 1,2-dimethylhydrazine (DMH) for sixteen weeks in Sprague Dawley rats with BEP neuron transplants or control neuron transplants, and their colonic histopathologies, colon tissue levels of pro-inflammatory cytokines and epithelial-mesenchymal transition (EMT) proteins and splenic levels of cytotoxic proteins were measured. (jcancer.org)
- Biallelic versions from the APC gene cause colon cancer inside genetic adenomatous polyposis coli (FAP) and also make functionality involving cut down goods inadequate internet domain names associated with beta-catenin wreckage but nevertheless having a minimum size. (bcl-2inhibitors.com)
- They include LINE-1 insertions interrupting coding exons of the adenomatous polyposis coli (APC) gene, identified first in a case of colon cancer in 1992 and again in an unrelated case this year by Scott Devine's group. (biomedcentral.com)
- Loss of heterozygosity has been shown in the adenomatous polyposis coli and mutated colon cancer and retinoblastoma locus in Barrett's cancers [ 9 , 10 ]. (oeso.org)
Kinase18
- We have identified a protein named DAP-1 that binds to the guanylate kinase-like domains of hDLG and PSD-95. (nih.gov)
- Glycogen synthase kinase-3 is central to multiple intracellular pathways including those activated by Wnt/β-catenin, Sonic Hedgehog, Notch, growth factor/RTK, and G protein-coupled receptor signals that contribute to neural development. (semanticscholar.org)
- BMP-2 upregulation of N-cadherin expression and resultant chondrogenesis required mitogsn activated protein kinase (MAPK) activity and tyrosine phosphorylation as downstream events. (jefferson.edu)
- A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of frog. (proconsortium.org)
- Several derivatives of 5-aminoimidazole-4-carboxamide-1--d-ribofuranoside (AICAR), an AMP-activated protein kinase (AMPK) activator, were identified as transcriptional activators of the DDT gene. (tokushima-u.ac.jp)
- Proteins normally associated with the apical junctional complexes of epithelial cells, such as Par-3, Par-6 and atypical protein kinase C (aPKC) have a role in polarization in vitro . (biomedcentral.com)
- Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5. (modencode.org)
- Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells. (modencode.org)
- It has also been indicated that PM2.5 may trigger asthma, chronic obstructive lung disease (COPD) and lung cancer through the activation of various signaling pathways, including AMP-activated protein kinase (AMPK) catalytic subunit α1 and signal transducer and activator of transcription (STAT)-1 ( 7 ). (spandidos-publications.com)
- It has also been suggested that vascular endothelial growth factor receptor (VEGF), mitogen-activated protein kinase (MAPK), nuclear factor κB (NF-κB) and interleukin (IL)-8 signaling is involved in PM2.5-induced lung injury ( 8 ). (spandidos-publications.com)
- Although the function of the CTLH complex remains unclear, here we used yeast two-hybrid screening to isolate Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) as a protein binding to a key component of CTLH complex, Armadillo repeat containing 8 (ARMc8) α. (openbiochemistryjournal.com)
- Fanning S § , Xu W § , Beaurepaire C, Suhan J, Nantel A, Mitchell A * . Functional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1. (cmu.edu)
- We have found that down-regulation of APC results in activation of the focal adhesion kinase (FAK) pathway, Src kinase, the STAT3 transcription factor, and epithelial membrane protein 2 (EMP2). (nd.edu)
- Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. (cocites.com)
- Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. (cocites.com)
- The atypical protein kinase Cs. (cocites.com)
- The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. (cocites.com)
- In the current study, we demonstrated that upregulation of miR-744 in pancreatic cancer promoted Wnt/β-catenin signaling by directly targeting secreted frizzled-related protein 1 (SFRP1), glycogen synthase kinase 3β (GSK3β), and transducin-like enhancer of split 3 (TLE3), important negative modulators of Wnt/β-catenin signaling. (oncotarget.com)
DP2.51
- Adenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene. (wikipedia.org)
Syndromes1
- Precise identification of the genetic cause of this condition has a profound impact on the management of FAP/AFAP family members, and there is therefore an acute need to identify new genetic abnormalities that could be responsible for a significant number of these adenomatous polyposis syndromes in APC/MUTYH mutation negative families. (vallhebron.com)
Catenin31
- The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion. (wikipedia.org)
- One protein with which APC associates is beta-catenin. (medlineplus.gov)
- The shortened protein is unable to interact with the beta-catenin protein, which prevents the breakdown of beta-catenin when it is no longer needed. (medlineplus.gov)
- The cadherin-catenin complex is expressed alternately with the adenomatous polyposis coli protein during rat incisor amelogenesis. (wikigenes.org)
- The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling. (embl.de)
- The separate journeys converged in 1993 when Paul Polakis, then at Onyx Pharmaceuticals Inc. of Richmond, Calif., and Kenneth Kinzler's group at Johns Hopkins University independently reported that the tumor suppressor protein adenomatous polyposis coli (APC) bound b catenin. (the-scientist.com)
- 2004. Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. . (oregonstate.edu)
- Other laboratories have recently reported that N-cadherin dependent cell adhesion requires intracellular associations with $\alpha $-, $\beta$-, and $\gamma$-catenin, and that the protein adenomatous polyposis coli (APC) may play a role in regulating these interactions. (jefferson.edu)
- Upon phosphorylation, the E3 ubiquitin ligase β-transducin repeats containing protein (β-TrCP) ubiquitinates phospho-β-catenin on Lys19 and Lys49 13,14 , which leads to proteasomal destruction and low β-catenin levels and activity 15,16 . (cytoskeleton.com)
- Conversely, in the presence of Wnt binding, the scaffold protein Dishevelled (Dvl) is recruited to the Fz-LRP5/6 co-receptor complex, which activates a sequence of molecular signals that inhibit the destruction complex and result in stabilization of unphosphorylated, cytosolic β-catenin and β-catenin-dependent transcription 2,3,17-19 . (cytoskeleton.com)
- Moreover, previous binding of APC 3×15 facilitates the association of β-catenin to the TATA box-associated protein. (uab.cat)
- The protein encoded by APC (Adenomatous polyposis coli), a tumour suppressor gene, plays a key role in the degradation of beta catenin. (gesundheitsindustrie-bw.de)
- The activated Dsh downregulates the protein complex, so that it can no longer phosphorylate β-catenin, which is then not degraded. (biomedcentral.com)
- On the lack of Wnt protein, beta catenin is certainly phosphorylated and quickly destructed by ubiquitin-proteaosome.14-16 Some works has indicated that BIO (6-bromoindirubin-3-oxim) can play as GSK-3 inhibitor mimicking the action of Wnt secretive molecules.17 BIO is a derivative of indirubin that is obtained from a trypan purple. (sprentland.com)
- The data suggest in which interaction among resistance methyltransferases along with the cell's personal ancient methyltransferases can start to play a huge role inside determining weight levels.The adenomatous polyposis coli (APC) proteins are an adverse regulator of the mitogenic transcribing factor beta-catenin by revitalizing it's proteasomal wreckage. (bcl-2inhibitors.com)
- The 4 20 protein repeats (15R) and also the 20R1 can also be beta-catenin-binding internet sites, but their part in beta-catenin degradation has remained cloudy. (bcl-2inhibitors.com)
- Emerin interacts with -catenin through a conserved adenomatous polyposis coli (APC)-like domain. (ncl.ac.uk)
- Immuno-histochemical staining showed the accumulation of β-catenin protein both in cytoplasm as well as in the nuclei of cancer cells when compared with normal tissue. (biomedcentral.com)
- Here, we aimed to explore the relationship among the Yes-associated protein, β-catenin, and Smoothened signaling pathways to provide a theoretical basis for the clinical diagnosis and Treatment program of invasive breast cancer. (researchsquare.com)
- Immunohistochemistry was used to detect the expression of Yes-associated protein, Smoothened protein, and β-catenin in breast cancer, adjacent, and normal tissues. (researchsquare.com)
- the expression of β-catenin and Smoothened protein in breast cancer tissues were all correlated with the human epidermal growth factor receptor expression. (researchsquare.com)
- The Yes-associated protein, β-catenin, and Smoothened protein can be used as new targets in the treatment of invasive breast cancer or as reference indicators for prognostic judgment. (researchsquare.com)
- c Assessment of β-catenin/TCF transcriptional activity through a TOPflash reporter assay in adenomatous polyposis coli-mutant DLD1 colorectal cancer cells. (biomedcentral.com)
- We found that IGF-1 stimulation enhanced tyrosine phosphorylation of two proteins, beta-catenin and insulin-receptor substrate 1, which formed a complex with E-cadherin. (ox.ac.uk)
- IGF-1 also enhanced the stability of beta-catenin protein. (ox.ac.uk)
- catenin interacts with this complicated and is after that phosphorylated on three described proteins (Ser33/Ser37/Thr41) by GSK-3 via the ubiquitin-proteasome pathway Rabbit polyclonal to APBB3 [33,35]. (uitest.info)
- The inner nuclear membrane protein Emerin regulates beta-catenin activity by restricting its accumulation in the nucleus. (core.ac.uk)
- Protein expression of E-cadherin was increased, whereas that of vimentin, Wnt4, β -catenin, and fibronectin was decreased in Shenning I-treated rats, when compared with the untreated UUO rats, as determined by immunohistochemistry and western blotting (P (scirp.org)
- beta catenin is also a gene regulatory protein that promotes cellular proliferation. (flashcardmachine.com)
- APC, (adenomatous polyposis coli), is a tumor suppressor gene whose main function is to down-regulate growth promoting signals, such as beta catenin. (flashcardmachine.com)
- XX FF beta-catenin links E-cadherin and APC to the cytoskeleton-associated protein alpha-catenin. (genexplain.com)
Phosphorylation7
- Unphosphorylated DISC1 regulates canonical Wnt signalling via an interaction with GSK3β, whereas specific phosphorylation at serine 710 (S710) triggers the recruitment of Bardet-Biedl syndrome (BBS) proteins to the centrosome. (nature.com)
- These data highlight a dual role for DISC1 in corticogenesis and indicate that phosphorylation of this protein at S710 activates a key developmental switch. (nature.com)
- Phosphorylation of DISC1 at S710 selectively increases binding of DISC1 with BBS proteins, resulting in enhanced BBS1 accumulation at the centrosome. (nature.com)
- Protein post-translational modifications (PTMs) such as phosphorylation, acetylation, ubiquitination, and SUMOylation, to name but a few, have evolved to diversify the functions of a single protein and account for the vast increase in proteome complexity and functional diversity 1 . (cytoskeleton.com)
- Stabilization occurs through partial inhibition of CK-1α and GSK318, inhibition of β-TrCP20, phosphorylation of five highly conserved PPPSP motifs in LRP6's intracellular domain 21,22 (Fig.1), and subsequent aggregation of these Wnt signaling proteins. (cytoskeleton.com)
- DIM inhibited survivin mRNA expression and promoted survivin protein degradation through inhibition of p34 cdc2 -cyclin B1-mediated survivin Thr 34 phosphorylation. (scialert.net)
- Iron is essential for all organisms, and iron-containing proteins catalyze a variety of crucial metabolic processes, such as oxidative phosphorylation and DNA synthesis, as well as cell-cycle progression and growth (Le and Richardson, 2002). (cyberleninka.org)
Cytoskeleton2
- PTHR12607 ADENOMATOUS POLYPOSIS COLI PROTEIN #* Intracellular cytoskeleton, role in structure of adherens junction. (geneontology.org)
- The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses. (cocites.com)
Microtubules3
- Proteins found in the microtubules. (nih.gov)
- Aided by adenomatous polyposis coli and KIF3A (a kinesin superfamily protein), proteins that travel along microtubules, these apical components accumulate at the tips of growing axons. (biomedcentral.com)
- Microtubules and their associated motor proteins play a variety of vital roles in orchestrating many processes within higher eukaryotes, such as membrane traffic and cell division. (manchester.ac.uk)
Degradation2
- Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. (cocites.com)
- The body also uses glutamic acid as a principal digestive enzyme in gastric juice, which controls the degradation of protein to peptones and hydrolyses peptide linkages. (medmelon.gr)
Tumour suppressor protein1
- The human homologue of the Drosophila discs large tumour suppressor protein (hDLG) and closely related proteins such as postsynaptic density protein 95 kDa (PSD-95) are associated with N-methyl-D-aspartate receptors (NMDA-R) and Shaker-type K+ channels, and are thought to be involved in their clustering. (nih.gov)
Association domain family 1A1
- Results: Gene promoters of SHH (P = 0.016), adenomatous polyposis coli (APC) (P = 0.003), secreted frizzled-related protein 5 (SFRP5) (P = 0.004) and Ras association domain family 1A (RASSF1A) (P = 0.023) showed significantly more methylation in BCC versus normal skin. (maastrichtuniversity.nl)
Regulates1
- A new paper in Molecular Biology of the Cell from the Rodal lab (in collaboration with the Nicastro lab and the Sokolova Lab at Lomonosov Moscow State University) describes a novel membrane deforming activity for Nervous Wreck (Nwk), an F-BAR protein that regulates trafficking of transmembrane growth signal receptors at the Drosophila neuromuscular junction. (brandeis.edu)
Tumors2
- Al-Hajj et al demonstrated that Compact disc44+/Compact disc24-/low cells within a breasts tumor, that are cells that express Compact disc44 proteins with detrimental GDC-0449 (Vismodegib) or faint appearance of Compact disc24 proteins, could actually form brand-new tumors in NOD/SCID mice whenever a few hundred of the cells were presented right into a mammary unwanted fat pad [23]. (uitest.info)
- Interactions of MSH6 with these proteins are critical for its MMR function and any structural alterations that interfere or harm these networks interactions would probably increase susceptibility to tumors formation and progression. (sapub.org)
Receptors4
- As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP families on the cell surface. (geneontology.org)
- receptors and their co-receptors are known as as low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) and accompanied by activation of Dishevelled family members proteins (DsH) which really is a key element of a membrane-associated Wnt receptor complicated. (sprentland.com)
- Wnt proteins transmit signals across cell membranes by interacting with Frizzled (Fzd) receptors and their co-receptor low-density lipoprotein receptor-associated protein (LRP)5 or LRP6. (scirp.org)
- ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. (cocites.com)
PMID1
- PMID 17221838 ] Association of adenomatous polyposis coli (APC) gene polymorphisms with autism spectrum disorder (ASD). (snpedia.com)
Escherichia3
- This region of AR-12 manufacturer Escherichia coli 16S rRNA by now consists of several methylated nucleotides such as mirielle(Four)Cm1402 as well as m(Your five)C1407. (bcl-2inhibitors.com)
- Connections to Escherichia coli are shown below. (vanderbilt.edu)
- Drug metabolism by Escherichia coli expressing human cytochromes P450. (vanderbilt.edu)
Binds1
- In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). (embl.de)
Cadherin7
- Cadherin-1 also known as CAM 120/80 or epithelial cadherin (E-cadherin) or uvomorulin is a protein that in humans is encoded by the CDH1 gene . (wikidoc.org)
- The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail . (wikidoc.org)
- Complete loss of E-cadherin protein expression in 84% of lobular breast carcinomas. (wikidoc.org)
- This thesis research investigates the regulation of N-cadherin-dependent cell adhesion by bone morphogenetic protein-2 (BMP-2) during chondrogenesis and the signaling events downstream of BMP-2 and/or N-cadherin required for chondrogenesis. (jefferson.edu)
- The thesis research presented here demonstrated that within 24 hours of BMP-2 treatment, C3H10T1/2 cells in high density micromass culture exhibit a 4-fold upregulation of N-cadherin mRNA, and by day 5 an 8-fold upregulation of N-cadherin protein. (jefferson.edu)
- Haas, Andrew Robert, "Chondrogenic induction by bone morphogenetic protein-2: Involvement of N-cadherin-associated functions" (1997). (jefferson.edu)
- these linkages are almost always indirect, and depend on the intracellular anchorage proteins assembling on the tail of the cadherin. (flashcardmachine.com)
Inactivation1
- About 85% of CRCs occur from occasions that bring about chromosomal instability (CIN) with aneuploidy and early inactivation of adenomatosis polyposis coli (APC). (flora2world.com)
Hereditary1
- The clinical syndrome due to mismatch repair gene deficiency is known as Hereditary Non-Polyposis Colorectal Cancer (HNPCC) and accounts for 2-5% of all colorectal cancer cases. (cdc.gov)
Membrane9
- Proteins that are related to the frizzled protein family in that they also contain the Wnt-binding site, but SFRP family are secreted and not membrane bound. (geneontology.org)
- When a mitotic signal is delivered by the Wnt pathway, by association of the Wg/Wnt family of secreted glycoproteins and their membrane receptor frizzled, it leads to activation of the dishevelled (Dsh) protein, which is recruited to the cell membrane. (biomedcentral.com)
- ZUD (ZU5 and deathdomain-containing protein), also known as UNC5CL (protein unc-5 homolog C-like), is a 518amino acid single-pass type III membrane protein that belongs to the unc-5 family. (sprentland.com)
- Emerin is a type II inner nuclear membrane (INM) protein of unknown function. (ncl.ac.uk)
- Sorting and processing of the proteins that span cell membranes requires extensive membrane remodeling , including budding, tubulation, and fission. (brandeis.edu)
- Until now, it was thought that proteins containing these F-BAR domains induced membrane tubulation by assembling in highly ordered helical coats on lipid bilayers. (brandeis.edu)
- The work done by the Rodal lab suggests that while basic self-assembly and membrane binding properties are likely conserved between F-BAR proteins, the higher-order organization of Nwk may account for differences in membrane remodeling and its specialized role in the cell. (brandeis.edu)
- A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. (princeton.edu)
- Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface. (lookformedical.com)
Regulation4
- Involved in negative regulation of protein localization to cell cortex and positive regulation of cell population proliferation. (nih.gov)
- Our research centres on microtubule motor proteins: their regulation, diversity and function, both in healthy cells and how their misfunction may contribute to disease. (manchester.ac.uk)
- Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells. (oru.se)
- The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). (lookformedical.com)
Apoptosis5
- The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. (antibodies-online.com)
- Hence, an understanding from the proteins mixed up in diverse stages of apoptosis give chances to discover new goals for treatment strategies [22]. (uitest.info)
- In addition, our research has shown that the motor protein cytoplasmic dynein is an early target for destruction during programmed cell death, and that disrupting cytoplasmic dynein function in otherwise normal cells can itself trigger apoptosis. (manchester.ac.uk)
- The bcl-2 proto-oncogene encodes a protein that blocks apoptosis and is involved in the development of follicular lymphoma by a chromosomal translocation. (oeso.org)
- NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP. (vanderbilt.edu)
Cytoplasmic3
- The ectodomain of this protein mediates bacterial adhesion to mammalian cells, and the cytoplasmic domain is required for internalization. (wikidoc.org)
- A 235-kDa cytoplasmic protein that is also found in platelets. (umassmed.edu)
- p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases. (cocites.com)
Antibodies4
- Antibodies are purified by protein a and peptide affinity chromatography. (queenscovecreative.com)
- Finally, tis sue and cell penetration of antibodies is often less effi cient than of compact chemical substances, as well as target protein requirements to get accessible for the antibody for being efficiently neutralized. (plcsignaling.com)
- In today's study, we present which the binding properties from the anti-polyQ antibodies MW1 and 3B5H10 support the linear lattice model for the framework of soluble polyQ in the framework of the huntingtin exon 1 fusion proteins. (pik-93.info)
- This model postulates that Varespladib both extended and regular polyQ tracts in Varespladib the preaggregation condition are random-coil buildings, with extended polyQ repeats filled with more epitopes acknowledged by antibodies or additional binding proteins than normal polyQ tracts [3]. (pik-93.info)
Pathways3
- Following protein pathways can lead to unexpected places. (the-scientist.com)
- The apc gene encodes a large 312-kda protein that has been shown to have multiple cellular functions and act through several molecular pathways. (queenscovecreative.com)
- Our results support recent findings that suggest that INM proteins can influence signalling pathways by restricting access of transcription coactivators to the nucleus. (ncl.ac.uk)
Metabolism2
- P62 and the sequestosome, a novel mechanism for protein metabolism. (cocites.com)
- Despite the multifunctionality of these proteins, GSTs are best known for their ability to transfer the tripeptide gamma-glutamyl-cysteinyl-glycine, also known as glutathione (GSH) to a wide variety of highly genotoxic and cell-damaging molecules, either directly occurred from the extracellular environment or from the intracellular detoxification metabolism. (frontiersin.org)
APC24
- Bi-allelic Loss of Human APC2, Encoding Adenomatous Polyposis Coli Protein 2, Leads to Lissencephaly, Subcortical Heterotopia, and Global Developmental Delay. (uniklinikum-dresden.de)
- A second adenomatous polyposis coli (APC)-like gene, APC2/APCL, was recently described and localized to chromosome 19. (sinica.edu.tw)
- Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. (sinica.edu.tw)
- Assignment of the murine adenomatous polyposis coli 2 (Apc2) gene to mouse chromosome band 10B5-C2 by in situ hybridisation. (sinica.edu.tw)
Genetic1
- Eighty-percent of colon cancers stem from a genetic mutation of the protein adenomatous polyposis coli, or APC. (uci.edu)
Cells14
- The APC protein helps control how often a cell divides, how it attaches to other cells within a tissue, how the cell polarizes and the morphogenesis of the 3D structures, or whether a cell moves within or away from tissue. (wikipedia.org)
- This protein also helps ensure that the chromosome number in cells produced through cell division is correct. (wikipedia.org)
- The APC protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. (medlineplus.gov)
- Furthermore, splenic NK cells cytolytic proteins such as perforin, granzyme B and IFN-γ levels in BEP neurons transplanted rats were higher than those in control rats. (jcancer.org)
- Identification of protease serine S1 family member 53 as a mitochondrial protein in murine islet beta cells, Islets, Vol.14, No.1, 1-13, 2021. (tokushima-u.ac.jp)
- FAP is caused by a mutation in the adenomatous polyposis coli (APC) gene coding for APC protein, which acts as a tumor suppressor and keeps cells from growing too fast or in an uncontrolled way. (eloxxpharma.com)
- EBV-miR-BART12 accelerates migration and invasion in EBV-associated cancer cells by targeting tubulin polymerization-promoting protein 1. (viictr.org)
- The expression level of Yes-associated protein in the MCF-7 cells was significantly higher than that in the MDA-MB-231 cells. (researchsquare.com)
- The specification of the ectodermal cells into the epidermal layer known as skin is governed by Wnt signaling stimulation wh-ich helps inhibit the response of ectoderm to fibroblast growth factors (FGFs).25 Without FGFs signaling, the ectodermal cells can express bone morphogenetic proteins (BMPs) and will start to form the epidermal characteristics.25,26. (samploon.com)
- classical cadherins are probably the most important proteins in adhering like cells, (homophilic adhesion), b/c they only like to bind to other cadherins of the same type. (flashcardmachine.com)
- We also track the movement of green fluorescent protein-tagged cargoes within living cells using timelapse fluorescence microscopy. (manchester.ac.uk)
- Now researchers at the Hebrew University of Jerusalem have studied ice-binding "antifreeze proteins" that protect frozen cells from expansion damage when they thaw out. (unitedwithisrael.org)
- Glutamic acid is one of the 20 amino acids commonly found in proteins - the body's building blocks of cells, enzymes, hormones and immune components. (medmelon.gr)
- Cancer cells can disrupt a metabolic pathway that breaks down fats and proteins to boost the levels of a byproduct called methylmalonic acid, thereby driving. (newzs.de)
Family of proteins1
- Members of the NAP/SET family of proteins interact specifically with B-type cyclins. (modencode.org)
Scaffold protein1
- Signal integration and diversification through the p62 scaffold protein. (cocites.com)
Intestinal1
- 2009. Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse. . (oregonstate.edu)
Mutation cluster region1
- Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours. (ous-research.no)
Interactions4
- Hence, we aimed to predict drug target proteins in F. nucleatum , through subtractive genomics approach and host-pathogen protein-protein interactions (HP-PPIs). (biomedcentral.com)
- Prediction of HP-PPIs exhibited 186 interactions contributed by 103 host and 76 bacterial proteins. (biomedcentral.com)
- Project leaders== Varsha Khodiyar, Suzi Lewis ==Justification (Impact and significance)== Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis. (geneontology.org)
- Proximity Ligation Analysis of protein-protein interactions between APC and CTNNB1. (abnova.com)
Extracellular matrix p1
- Liver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-beta and extracellular matrix proteins. (shengsci.com)
Mice3
- Apc1638t homozygous mice contain a c-terminally deleted apc protein capable of. (queenscovecreative.com)
- CABS1 is a novel calcium-binding protein specifically expressed in elongate spermatids of mice. (modencode.org)
- C57BL/6J mice carrying the Min allele of Adenomatous polyposis coli (Apc) develop numerous adenomas along the entire length of the intestine and consequently die at an early age. (isharonline.org)
Amino Acid4
- It is not known if this large predicted unstructured region from amino acid 800 to 2843 persists in vivo or would form stabilised complexes - possibly with yet unidentified interacting proteins. (wikipedia.org)
- This mutation results in the substitution of the amino acid lysine for isoleucine at position 1307 in the APC protein (also written as I1307K or Ile1307Lys). (wikipedia.org)
- This mutation replaces the amino acid isoleucine with the amino acid lysine at position 1307 in the APC protein (written as Ile1307Lys or I1307K). (medlineplus.gov)
- A (p.Pro2467Thr) results in a non-conservative amino acid change located in the Adenomatous polyposis coli protein basic domain (IPR009234) of the encoded protein sequence. (utah.edu)
Inhibits1
- The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). (antibodies-online.com)
Polyclonal4
- Rabbit polyclonal antibody against apc protein. (queenscovecreative.com)
- The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera. (arrestins.com)
- Rabbit polyclonal to ZU5.Proteins containing the death domain (DD) are involved in a wide range of cellular processes,and play an important role in apoptotic and inflammatory processes. (sprentland.com)
- Rabbit polyclonal antibody raised against a full-length human APC protein. (abnova.com)