Pulmonary Adenomatosis, Ovine: A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.Adenoma, Liver Cell: A benign epithelial tumor of the LIVER.Betaretrovirus: A genus of the family RETROVIRIDAE consisting of viruses with either type B or type D morphology. This includes a few exogenous, vertically transmitted and endogenous viruses of mice (type B) and some primate and sheep viruses (type D). MAMMARY TUMOR VIRUS, MOUSE is the type species.Multiple Endocrine Neoplasia: A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively.Intestinal Polyposis: The growth of INTESTINAL POLYPS. Growth processes include neoplastic (ADENOMA and CARCINOMA) and non-neoplastic (hyperplastic, mucosal, inflammatory, and other polyps).Lynestrenol: A synthetic progestational hormone used often in mixtures with estrogens as an oral contraceptive.Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Adenomatosis, Pulmonary: A neoplastic disease in which the alveoli and distal bronchi are filled with mucus and mucus-secreting columnar epithelial cells. It is characterized by abundant, extremely tenacious sputum, chills, fever, cough, dyspnea, and pleuritic pain. (Stedman, 25th ed)Adenomatous Polyposis Coli: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.Intestinal Polyps: Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.Adenoma: A benign epithelial tumor with a glandular organization.Sheep: Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.Liver Neoplasms: Tumors or cancer of the LIVER.New Zealand: A group of islands in the southwest Pacific. Its capital is Wellington. It was discovered by the Dutch explorer Abel Tasman in 1642 and circumnavigated by Cook in 1769. Colonized in 1840 by the New Zealand Company, it became a British crown colony in 1840 until 1907 when colonial status was terminated. New Zealand is a partly anglicized form of the original Dutch name Nieuw Zeeland, new sea land, possibly with reference to the Dutch province of Zeeland. (From Webster's New Geographical Dictionary, 1988, p842 & Room, Brewer's Dictionary of Names, 1992, p378)Security Measures: Regulations to assure protection of property and equipment.Legislation as Topic: The enactment of laws and ordinances and their regulation by official organs of a nation, state, or other legislative organization. It refers also to health-related laws and regulations in general or for which there is no specific heading.Legislation, Medical: Laws and regulations, pertaining to the field of medicine, proposed for enactment or enacted by a legislative body.Containment of Biohazards: Provision of physical and biological barriers to the dissemination of potentially hazardous biologically active agents (bacteria, viruses, recombinant DNA, etc.). Physical containment involves the use of special equipment, facilities, and procedures to prevent the escape of the agent. Biological containment includes use of immune personnel and the selection of agents and hosts that will minimize the risk should the agent escape the containment facility.Disease Notification: Notification or reporting by a physician or other health care provider of the occurrence of specified contagious diseases such as tuberculosis and HIV infections to designated public health agencies. The United States system of reporting notifiable diseases evolved from the Quarantine Act of 1878, which authorized the US Public Health Service to collect morbidity data on cholera, smallpox, and yellow fever; each state in the US has its own list of notifiable diseases and depends largely on reporting by the individual health care provider. (From Segen, Dictionary of Modern Medicine, 1992)Pest Control: The reduction or regulation of the population of noxious, destructive, or dangerous plants, insects, or other animals. This includes control of plants that serve as habitats or food sources for animal pests.Tourette Syndrome: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)Cat's Claw: A vine (Uncaria tomentosa) indigenous to the Amazon rainforest whose name is derived from its hook-like thorns. It contains oxindole alkaloids and glycosides and has many medicinal uses.Blepharospasm: Excessive winking; tonic or clonic spasm of the orbicularis oculi muscle.Togaviridae: A family of RNA viruses, mainly arboviruses, consisting of two genera: ALPHAVIRUS (group A arboviruses), and RUBIVIRUS. Virions are spherical, 60-70 nm in diameter, with a lipoprotein envelope tightly applied to the icosahedral nucleocapsid.Hysteria: Historical term for a chronic, but fluctuating, disorder beginning in early life and characterized by recurrent and multiple somatic complaints not apparently due to physical illness. This diagnosis is not used in contemporary practice.Compulsive Behavior: The behavior of performing an act persistently and repetitively without it leading to reward or pleasure. The act is usually a small, circumscribed behavior, almost ritualistic, yet not pathologically disturbing. Examples of compulsive behavior include twirling of hair, checking something constantly, not wanting pennies in change, straightening tilted pictures, etc.France: A country in western Europe bordered by the Atlantic Ocean, the English Channel, the Mediterranean Sea, and the countries of Belgium, Germany, Italy, Spain, Switzerland, the principalities of Andorra and Monaco, and by the duchy of Luxembourg. Its capital is Paris.Vascular Endothelial Growth Factor D: A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR C in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.Lymphangiogenesis: The formation of LYMPHATIC VESSELS.Vascular Endothelial Growth Factor A: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Vascular Endothelial Growth Factor C: A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR D in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Vascular Endothelial Growth Factor Receptor-3: A vascular endothelial cell growth factor receptor whose expression is restricted primarily to adult lymphatic endothelium. VEGFR-3 preferentially binds the vascular endothelial growth factor C and vascular endothelial growth factor D and may be involved in the control of lymphangiogenesis.Internal Medicine: A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)Hirsutism: A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.Angiography: Radiography of blood vessels after injection of a contrast medium.Polycythemia: An increase in the total red cell mass of the blood. (Dorland, 27th ed)Meibomian Glands: The sebaceous glands situated on the inner surface of the eyelids between the tarsal plates and CONJUNCTIVA.Sebaceous Glands: Small, sacculated organs found within the DERMIS. Each gland has a single duct that emerges from a cluster of oval alveoli. Each alveolus consists of a transparent BASEMENT MEMBRANE enclosing epithelial cells. The ducts from most sebaceous glands open into a HAIR FOLLICLE, but some open on the general surface of the SKIN. Sebaceous glands secrete SEBUM.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Gingival NeoplasmsNose Neoplasms: Tumors or cancer of the NOSE.Gingival DiseasesCarcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)BooksAtlases as Topic: Collections of illustrative plates, charts, etc., usually with explanatory captions.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Radiology Information Systems: Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of radiology services and facilities.Photography: Method of making images on a sensitized surface by exposure to light or other radiant energy.Cervical Atlas: The first cervical vertebra.Clinical Chemistry Tests: Laboratory tests demonstrating the presence of physiologically significant substances in the blood, urine, tissue, and body fluids with application to the diagnosis or therapy of disease.

The association between atypical adenomatous hyperplasia and primary lung cancer. (1/11)

Atypical adenomatous hyperplasia (AAH) has been suggested as the adenoma in an adenoma-carcinoma sequence in the lung periphery. From 1989-1998, we undertook a systematic, prospective search for AAH in lungs resected for cancer. AAH was found in 67 of 554 patients (12. 1%) with primary lung carcinoma (9.2% in male patients and 19.0% in females). AAH was found in lungs bearing adenocarcinoma (23.2%) more frequently than with large cell undifferentiated carcinoma (12.5%) or squamous carcinoma (3.3%). A greater percentage of females with adenocarcinoma had AAH (30.2%) than did males with adenocarcinoma (18.8%). Numbers of AAH ranged from 1-42 per patient and more patients had small numbers of AAH, although 12 patients had 6 or more AAH foci. Larger numbers of AAH tended to be found in adenocarcinoma-bearing lungs. Ten of the 67 patients with AAH and primary lung carcinoma (15%) had multiple primary cancers (range 2-6), all of which were adenocarcinoma. Synchronous cancers were rare in lung tumour-bearing resections without AAH. Patients with AAH show no difference in post-operative survival to those without, for all stages of carcinoma and for Stage I disease alone. This study provides evidence for a strong association between atypical adenomatous hyperplasia and primary lung adenocarcinoma and lends weight to the AAH/adenoma-carcinoma hypothesis.  (+info)

Atypical adenomatous hyperplasia of the lung: a probable forerunner in the development of adenocarcinoma of the lung. (2/11)

An increasingly large body of work suggests that atypical adenomatous hyperplasia (AAH) of the lung may be a forerunner of pulmonary adenocarcinoma. Recognizing this fact, the World Health Organization now acknowledges the existence of AAH while noting difficulties that may be encountered in distinguishing AAH from the nonmucinous variant of bronchioloalveolar carcinoma. Regrettably, a universally acceptable definition of morphologic criteria for the diagnosis of AAH has not been achieved. This review of the literature examines the epidemiology, gross appearance, light microscopic findings, morphometry, immunohistochemistry, and molecular features of AAH and suggests a set of histopathologic features that may help the practicing pathologist identify this intriguing lesion. These features include the following: irregularly bordered focal proliferations of atypical cells spreading along the preexisting alveolar framework; prominent cuboidal to low columnar alveolar epithelial cells with variable degree of atypia but less than that seen in adenocarcinoma; increased cell size and nuclear-cytoplasmic ratio with hyperchromasia and prominent nucleoli, generally intact intercellular attachment of atypical cells with occasional empty-looking spaces between them without high cellularity and without tufting or papillary structures; and slight thickening of the alveolar walls on which the AAH cells have spread, with some fibrosis but without scar formation or significant chronic inflammation of the surrounding lung tissue. Several lines of evidence indicate that AAH is a lesion closely associated with adenocarcinoma of the lung, suggesting AAH may be involved in the early stage of a complex multistep carcinogenesis of pulmonary adenocarcinoma.  (+info)

Atypical adenomatous hyperplasia of the lung: a clinicopathological study of 118 cases including cases with multiple atypical adenomatous hyperplasia. (3/11)

BACKGROUND: Atypical adenomatous hyperplasia (AAH) of the lung is a putative precursor lesion of adenocarcinoma, according to many immunohistochemical and genetical studies, but few clinicopathological studies on a large number of cases have been reported. The aim of this study was to clarify the clinicopathological characteristics of lung cancer patients with AAH lesions. METHODS: A retrospective study was carried out on 508 consecutive primary lung cancer patients operated on at National Cancer Center Hospital East. The relationship between the number and location of AAH lesions and the clinicopathological features of the lung cancer patients was analysed statistically. RESULTS: A total of 311 AAH lesions were found in 118 (23.2%) of the 508 cases. AAH lesions were detected in 121 of 572 lobes examined, usually in both upper lobes, and occurred most frequently in patients with adenocarcinoma (OR 2.97; 95% CI 1.82 to 4.85). AAH lesions were more frequently detected in patients with multiple primary carcinomas than in those with a single carcinoma (OR 3.06; 95% CI 1.56 to 6.00). The presence of AAH lesions was not significantly correlated with sex, age, smoking status, familial history of malignancy, or preceding malignancy. Patients with multiple AAH lesions were found to have a significantly higher frequency of preceding malignancies. CONCLUSIONS: The present study highlights the clinicopathological characteristics of AAH lesions, showing them to be significantly associated with both adenocarcinoma and multiple primary carcinoma of the lung and suggesting common factors in the histogenesis of multiple AAH lesions and preceding malignancy.  (+info)

Fine chromosomal localization of the mouse Par2 gene that confers resistance against urethane-induction of pulmonary adenomas. (4/11)

BALB/cByJ mice are 14 times more resistant to urethane-induction of pulmonary adenomas than the susceptible A/J strain. Our previous linkage analysis of (A/J x BALB/cByJ)F1 x A/J backcross mice provided statistical evidence that a major resistance locus of BALB/cByJ with a dominant effect, designated Par2 (Pulmonary adenoma resistance 2), exists within an approximately 25 cM section of distal chromosome 18. To facilitate molecular identification of the Par2 locus, the present study was conducted to finely localize its chromosomal position utilizing Par2-congenic mice. Male BALB/cByJ mice were mated with female C57BL/6J mice carrying recessive Par2 alleles and their male F1 progeny were backcrossed to female BALB/cByJ mice. A male backcross mouse heterozygous within the Par2 interval of 25 cM was randomly selected and again backcrossed to female BALB/cByJ mice. This backcross-selection cycle was simply repeated to produce semi-congenic mice with a general BALB/cByJ genetic background except for the Par2 interval, where the mice were heterozygous with paternal C57BL/6J alleles and maternal BALB/cByJ alleles. After the 6th or 7th backcross, nine male mice possessing a recombination within the paternal Par2 interval were retained and crossed to female A/J mice. Resultant progeny were treated with urethane and examined for lung tumor development in order to deduce the Par2 genotypes of the recombinants through linkage analysis. By comparing the deduced Par2 genotype of each recombinant with its recombinational breakpoint, the Par2 locus was confined to an approximately 0.5 cM region flanked by D18Mit103 and D18Mit188 loci. Our results indicate that fully congenic mice conventionally established by at least nine simple backcrosses or by the speed congenic method are not necessarily required for fine mapping of quantitative trait loci. In the case of the Par2 locus, we found that semi-congenic mice after as few as four simple backcrosses were useful for this purpose. The map information obtained in this study should enable subsequent positional cloning of the Par2 gene.  (+info)

A case of multiple atypical adenomatous hyperplasia of the lung detected by computed tomography. (5/11)

Multiple atypical adenomatous hyperplasia (AAH) of both lungs in a 72-year-old male, detected by computed tomography, is reported. The lesions of the right lung were resected for diagnosis via video-assisted thoracoscopic surgery (VATS). The resected specimen had 22 AAH lesions up to 10 mm in size. For nine of these lesions, the expressions of carcinoembryonic antigen (CEA), c-erbB-2 oncoprotein and p53 gene product were examined by immunohistochemistry and the loss of heterozygosity (LOH) on chromosomes was investigated by polymerase chain reaction analysis. These lesions showed a variety of expressions for CEA, c-erbB-2 and p53 oncoprotein. Three of the nine lesions showed LOH on chromosome 13q, although this was not exhibited in the largest one. These results indicate that each AAH in this case has independent genetic abnormalities and is multicentric.  (+info)

Multiple atypical adenomatous hyperplasia with synchronous multiple primary bronchioloalveolar carcinomas. (6/11)

We report a case of multiple atypical adenomatous hyperplasia (AAH) associated with synchronous multiple primary bronchioloalveolar carcinomas (BACs). A 58-year-old man was visited for bronchial asthma. A chest computed tomography (CT) scan revealed small, multiple nodules with ground glass attenuation (GGA) throughout both lungs, predominantly in the upper lobes. A high resolution CT (HRCT) scan disclosed well-defined nodules with uniform GGA. Thoracoscopic wedge lung biopsy confirmed the diagnosis. The patient was treated with chemotherapy and had stable disease for two years. It is important to recognize that multiple AAH associated with multiple BACs can present as diffuse, well-defined nodules with uniform GGA on HRCT.  (+info)

Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice. (7/11)

The lymphoma-inducing potential of Ig heavy-chain enhancer- and promoter-regulated Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) was evaluated in three transgenic FVB mouse lineages. EBNA1 was expressed at a higher level in transgenic B220(+) splenocytes than in EBV-infected lymphoblastoid cell lines. EBNA1 was also expressed in B220(-) transgenic splenocytes and thymocytes. Before killing and assessments at 18-26 months, EBNA1-transgenic mice did not differ from control mice in mortality. At 18-26 months EBNA1-transgenic mice did not differ from littermate control in ultimate body weight, in spleen size or weight, in lymph node, kidney, liver, or spleen histology, in splenocyte fractions positive for cluster of differentiation (CD)3epsilon, CD4, CD8, CD62L, B220, CD5, IgM, IgD, MHC class II, CD11b, or CD25, or in serum IgM, IgG, or total Ig levels. Lymphomas were not found in spleens or other organs of 18- to 26-month-old EBNA1-transgenic (n=86) or control (n=45) FVB mice. EBNA1-transgenic lineages had a higher pulmonary adenoma prevalence than did littermate controls (39% versus 7%). However, the adenoma prevalence was not higher in EBNA1-transgenic mice than has been described for FVB mice, and EBNA1 was not expressed in normal pulmonary epithelia or adenomas.  (+info)

Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung. (8/11)

Activating epidermal growth factor receptor (EGFR) gene mutations are frequently detected in lung adenocarcinomas, especially adenocarcinomas with a nonmucinous bronchioloalveolar carcinoma component. EGFR-mutated lung adenocarcinomas respond well to EGFR tyrosine kinase inhibitors. We previously found that most (88%) pure nonmucinous bronchioloalveolar carcinomas (adenocarcinoma in situ) already harbor EGFR mutations, indicating that the mutations are an early genetic event in the pathogenesis. We examined 54 atypical adenomatous hyperplasias, precursor lesions of lung adenocarcinomas, obtained from 28 Japanese patients for the hotspot mutations of EGFR exons 19 and 21 and K-ras codon 12. EGFR mutations were observed in 17 of the 54 (32%) atypical adenomatous hyperplasias examined: Ten and seven atypical adenomatous hyperplasias had deletion mutations at exon 19 or point mutations (L858R) at exon 21, respectively. We did not observe apparent histological differences between atypical adenomatous hyperplasias with and without EGFR mutations. K-ras mutation (G12S) was detected in only one atypical adenomatous hyperplasia. As EGFR mutational frequency of atypical adenomatous hyperplasias was much lower than that of nonmucinous bronchioloalveolar carcinomas, we surmise that EGFR-mutated atypical adenomatous hyperplasias, but not atypical adenomatous hyperplasias with wild-type EGFR, are likely to progress to nonmucinous bronchioloalveolar carcinomas.  (+info)

34βE12. Keratin, HMW Ab-3 (1/50; Clone 34 beta E12; MS-1447-S1; Neomarkers.). The streptavidine biotin/horseradish peroxidase (Str.AB/HRP) methods were used to show keratin immunoexpression. A drop of Ultra V Block (Ultra Vision Kit; TP-125-HL; Lab Vision) was applied to the slide to block nonspecific dying.. The tissues were incubated for 10 seconds with biotinylated biotineted secondary antibody. Streptavidine Peroxidase was applied. DAB was used as a chromogen. Cytoplasmic brown painting in the basal cells was evaluated as positive.. Results and Discussion. A comparison of the AAH and PACG 1, 2 lesions (Figure 1) in terms of luminal material parameters and the statistical analysis of the results are shown in Table 1. Intraluminal crystalloids were present 13.7% of AAH and 63.6% of PACG 1, 2 lesions (Figure 2). Mucin was not detected in any AAH lesion but was present in 36.4% of PACG 1, 2 lesions (Figure 3). Corpora amylacea were present in 72.3% of AAH and 27.3% of PACG 1, 2 lesions (Figure ...
Vandetanib (ZactimaTM) is a novel, orally available inhibitor of both vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinase. In the present study, a line of transgenic mice with a mouse Egfr gene mutation (delE748-A752) corresponding to a human EGFR mutation (delE746-A750) was established. The transgenic mice developed atypical adenomatous hyperplasia to adenocarcinoma of the lung at around 5 weeks of age and died of lung tumors at approximately 17 weeks of age. In the mice treated with vandetanib (6mg/kg/day), these lung tumors disappeared and the phosphorylations of EGFR and VEGFR-2 were reduced in lung tissues to levels comparable to those of non-transgenic control mice. The median overall survival time of the transgenic mice was 28 weeks in the vandetanib-treated group and 17 weeks in the vehicle-treated group. Vandetanib significantly prolonged the survival of the transgenic mice (log-rank test, p<0.01); resistance to ...
UroToday - GU OncToday brings coverage of the clinically relevant content needed to stay at the forefront of the dynamic field of GU oncology and urology.
Vandetanib (ZactimaTM) is a novel, orally available inhibitor of both vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinase. In the present study, a line of transgenic mice with a mouse Egfr gene mutation (delE748-A752) corresponding to a human EGFR mutation (delE746-A750) was established. The transgenic mice developed atypical adenomatous hyperplasia to adenocarcinoma of the lung at around 5 weeks of age and died of lung tumors at approximately 17 weeks of age. In the mice treated with vandetanib (6mg/kg/day), these lung tumors disappeared and the phosphorylations of EGFR and VEGFR-2 were reduced in lung tissues to levels comparable to those of non-transgenic control mice. The median overall survival time of the transgenic mice was 28 weeks in the vandetanib-treated group and 17 weeks in the vehicle-treated group. Vandetanib significantly prolonged the survival of the transgenic mice (log-rank test, p<0.01); resistance to ...
Cellular atypia in rodent lungs is characterized by one or more of the following features: cytoplasmic basophilia, hyperchromatic nuclei, loss of nuclear polarity, high nuclear to cytoplasmic ratio, karyomegaly, anisokaryosis, and pleomorphism. The atypical cells are often poorly differentiated and may be binucleated. They may have multiple and/or enlarged nucleoli. In the pathology literature, cellular atypia, atypical hyperplasia, and atypical adenomatous hyperplasia have been used synonymously with dysplasia to signify cells and nuclei with abnormal size, shape, organization, and/or tinctoral properties. While individual cells in the alveoli may have features of atypia, cellular atypia can also be seen in areas of bronchial, bronchiolar, or alveolar epithelial hyperplasia or squamous metaplasia. Some of the features listed above may also be seen in regenerating cells (e.g., cytomegaly, karyomegaly, cytoplasmic basophilia, increased nuclear to cytoplasmic ratio). The biological significance of ...
Kirkby R., Scase T., Wakeling J.E., et al. Journal of Veterinary Internal Medicine, 2006. 20(6): p.1522. In human patients, a well-defined syndrome of sub
The abdomen of Wistar rats was irradiated locally with 1000 to 2000 rads. Approximately 2 months following irradiation, visible nodules were found in the intestines of the groups receiving irradiation. Nodule incidence was 80 to 100% in groups that received 1750 or 2000 rads, 50% in the 1500-rad groups, and 3% in the 1000-rad groups, respectively.. The histology of the nodules revealed adenomatous hyperplasia, including invasion of submucosa, muscle layers, and serosa of the small intestine accompanied by an area of fibrous tissue resulting from desmoplastic reaction by irradiation injury.. ...
TY - JOUR. T1 - Association of CYP19A1 polymorphisms with risks for atypical adenomatous hyperplasia and bronchioloalveolar carcinoma in the lungs. AU - Kohno, Takashi. AU - Kakinuma, Ryutaro. AU - Iwasaki, Motoki. AU - Yamaji, Taiki. AU - Kunitoh, Hideo. AU - Suzuki, Kenji. AU - Shimada, Yoko. AU - Shiraishi, Kouya. AU - Kasuga, Yoshio. AU - Hamada, Gerson Shigeaki. AU - Furuta, Koh. AU - Tsuta, Koji. AU - Sakamoto, Hiromi. AU - Kuchiba, Aya. AU - Yamamoto, Seiichiro. AU - Kanai, Yae. AU - Tsugane, Shoichiro. AU - Yokota, Jun. PY - 2010/8/5. Y1 - 2010/8/5. N2 - Estrogen has been indicated to play an etiological role in the development of lung adenocarcinoma (ADC), particularly bronchioloalveolar carcinoma (BAC), a type of ADC that develops from a benign adenomatous lesion, atypical adenomatous hyperplasia (AAH). Polymorphisms in the CYP19A1 gene cause interindividual differences in estrogen levels. Here, 13 CYP19A1 singlenucleotide polymorphisms (SNPs) were examined for associations with lung ...
We report on 2 infants with PHHI for whom focal lesions of the pancreas were diagnosed during laparoscopy and laparoscopically enucleated. Both children were cured at the age of 1 month. One year after surgery, both patients are well and normoglycemic. Functional data from patient tissue analyses and genotyping in both cases revealed that PHHI was a consequence of defects in β-cell KATP channels. For both children, mutations in the SUR1 gene were found; the mutations were of paternal origin in both cases, as reported for focal hyperinsulinism. The focal origins of PHHI were confirmed with histologic diagnoses.. Focal adenomatous hyperplasia as a cause of PHHI was observed first by Kloppel et al7 in 1975 and was noted by Goossens et al8 in 1989 in a large study of 24 pancreata from surgically treated patients with PHHI. Since those observations, focal lesions as a cause of intractable hyperinsulinism have been consistently reported. The presumed incidence may be as high as 30% to 60% of cases of ...
Estrogen has been indicated to play an etiological role in the development of lung adenocarcinoma (ADC), particularly bronchioloalveolar carcinoma (BAC), a type of ADC that develops from a benign adenomatous lesion, atypical adenomatous hyperplasia (AAH). Polymorphisms in the CYP19A1 gene cause interindividual differences in estrogen levels. Here, 13 CYP19A1 single-nucleotide polymorphisms (SNPs) were examined for associations with lung AAH risk. AAH is detected as ground-glass opacity (GGO) by computed tomography (CT) examination, and this study consisted of 100 individuals diagnosed with GGO in their lungs among 3088 CT-based cancer screening examinees and 424 without. Minor allele carriers for the rs3764221 SNP showed an elevated risk for GGO [odds ratio (OR) = 1.72, P = 0.017]. Associations of this SNP with risks for lung AAH and BAC in the lungs were next examined using 359 ADC cases whose resected lung lobes were subjected to a histological examination for AAH accompaniment and the ...
No previous study has investigated neutral large amino acid transporter type 1 (LAT1) in normal lung cells, or in atypical adenomatous hyperplasia(s) (AAH) and nonmucinous bronchioloalveolar carcinoma(s) (NMBAC) of the lung. The authors examined: (1) the levels of LAT1 mRNA/glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA in 41 normal lung tissues and 34 NMBAC using semiquantitative reverse transcription-polymerase chain reaction; (2) LAT1 mRNA and protein expressions in 35 normal lung tissues, 34 AAH (11 lesions were interpreted as low-grade AAH and 23 as high-grade AAH), and 43 NMBAC using in situ hybridization and immunohistochemistry; and (2) the association of the incidences of LAT1 mRNA and protein expressions with cell proliferation in these lesions. The level of LAT1 mRNA/GAPDH mRNA (1) tended to be higher in NMBAC (12.0+/-8.1) than in normal lung tissues (1.0+/-0.2), and (2) covered a much wider range (from 0 to 276) in NMBAC than in normal lung tissues (from 0 to 5.8), with six ...
Persistent GGO are usually classified as adenocarcinomas, ranging from premalignant lesions (atypical adenomatous hyperplasia) to invasive disease. They are generally slow-growing lesions. Because their significance can be difficult to determine, optimal follow-up and management are not clearly known. The prognosis of these lesions is driven by their histologic characteristics, which are available only after surgical resection.. The Mayo Clinic team tackling the uncertainties of GGOs includes biomedical imaging engineers, pathologists, pulmonologists and radiologists. They are developing CANARY as a noninvasive quantitative imaging tool designed to differentially categorize CT-detected peripheral subsolid lung nodules and predict underlying pathology and prognosis. Preliminary data suggest that CANARY, utilizing volumetric histogram density analysis (so-called radiologic biopsies), effectively risk-stratifies these nodules.. To further validate this technology, CANARY researchers are using data ...
1. Carruba G, Stefano R, Cocciaeliferro L. Intercellular communication and human prostate carcinogenesis. Ann NY Acad Sci. 2002;963:156-68 2. Goldstein NS, Underhiel J, Roszka N, Neill JS. Cytokeratin 34 beta E-12 immunoreactivity in benign prostate acini. Quantitation, pattern assessment, and electron microscopic study. Am J Clin Pathol. 1999;112:69-74 3. Bonkhoff H, Wernert N, Dhom G, Remberger K. Basement membranes in fetal, adult normal, hyperplastic and neoplastic human prostate. Virchows Arch A Pathol Anat Histopathol. 1991;418:375-81 4. Kosir MA, Wang W, Zukowski KL, Tromp G. Degradation of basement membrane by prostate tumor heparanase. J Surg Res. 1999;81:42-7 5. Bonkhoff H, Remberger K. Morphogenesis of benign prostatic hyperplasia and prostatic carcinoma. Pathology. 1998;19:12-20 6. Bostwick DG. Prospective origins of prostate carcinoma. Prostate intraepithelial neoplasia and atypical adenomatous hyperplasia. Cancer. 1996;78:330-6 7. Haggman MJ, Macoska JA, Wojno KJ, Oesterling JE. ...
The Extent and Zonal Location of Prostatic Intraepithelial Neoplasia and Atypical Adenomatous Hyperplasia : Relationship with Carcinoma in Radical Prostatectomy Specimens ...
Kass P.H., Peterson M.E., Levy J., et al. , 1999. 13(4): p.323-9. The pathologic changes associated with hyperthyroidism (adenomatous hyperplasia, adenoma of
2.0 2.1 2.2 2.3 2.4 Kobashi, Y.; Sugiu, T.; Mouri, K.; Irei, T.; Nakata, M.; Oka, M. (Jun 2008). "Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis: differentiation from multiple atypical adenomatous hyperplasia.". Jpn J Clin Oncol 38 (6): 451-4. doi:10.1093/jjco/hyn042. PMID 18535095. ...
Bronchioloalveolar carcinoma is a type of cancer that occurs in the alveoli of the lungs. Signs of bronchioloalveolar carcinoma...
inhibitor, just about everyone who responds eventually has the cancer become resistant.. Every treatment is likely to have some side effects, and some can be serious. She may go a very, very long time without it affecting her quality of life or survival. The key question I think needs to be asked is not "should we do nothing or do something?", but rather, "do you want to blow your best options while shes feeling fine and potentially without symptoms for years, or do you want to save your treatments for when you need them?" Its not now or never, but now or later. And how bad would it be if she went on a treatment and had a serious or fatal complication? Fortunately, thats not likely, but its possible to have permanent problems or even die from chemo or tarceva or avastin complications. Its tremendously unfortunate if it happens, but if its a setting of facing an imminent disease-induced problem, thats less of a travesty than if were treating a scan rather than the person.. Clinical trials ...
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TY - JOUR. T1 - Bronchioloalveolar Carcinoma. T2 - Clinical, Histopathologic, and Radiologic Findings. AU - Lee, Kyung Soo. AU - Kim, Yookyung. AU - Han, Jungho. AU - Ko, Eun Joo. AU - Park, Choong Ki. AU - Primack, Steven L.. PY - 1997/1/1. Y1 - 1997/1/1. N2 - Bronchioloalveolar carcinoma is characterized pathologically by a pulmonary neoplasm showing lepidic growth. More than half of all patients with bronchioloalveolar carcinoma are asymptomatic. The most frequent symptoms and signs are cough, sputum, shortness of breath, weight loss, hemoptysis, and fever. Bronchorrhea is unusual and a late manifestation. Nonmucinous bronchioloalveolar carcinoma tends to be more localized and has a lower frequency of bronchogenic spread than mucinous bronchioloalveolar carcinoma. Bronchioloalveolar carcinoma appears radiographically as a single nodule, segmental or lobar consolidation, or diffuse nodules. At computed tomography (CT), the single nodular form appears as a peripheral nodule or localized ...
TY - JOUR. T1 - Clinical features of bronchioloalveolar carcinoma with new histologic and staging definitions. AU - Ebbert, Jon O.. AU - Chhatwani, Laveena. AU - Aubry, Marie Christine. AU - Wampfler, Jason. AU - Stoddard, Shawn. AU - Zhang, Fang. AU - Qiao, Guibin. AU - De Andrade, Mariza. AU - Yang, Ping. PY - 2010/8. Y1 - 2010/8. N2 - Introdution: To assess clinical features of bronchioloalveolar carcinoma (BAC) based on the 1999 World Health Organization Classification ("pure BAC"), compare patients with pure BAC with patients previously diagnosed as BAC not meeting the 1999 definition, and compare survival changes of pure BAC based on the old and new (2009) staging systems. Methods:A pulmonary pathologist reviewed each BAC tumor diagnosed between January 1, 1997, and December 31, 2007, identifying cases meeting the new criteria. Cases were restaged according to the seventh edition of the tumor, node, metastasis classification introduced in 2009. Patients with pure BAC were analyzed under ...
In this issue of Oncology, Levy and colleagues provide a comprehensive review of bronchioloalveolar carcinoma [BAC], with a focus on the management of this rare disease, which represents 4% of all lung cancers.[1] The definition of BAC was revised by the World Health Organization (WHO) in 2004, with changes made to the diagnostic criteria and classification.[2] BAC was defined as an adenocarcinoma of the lung that grows in a lepidic fashion along the alveolar septa without invasion of stroma, blood vessels, or pleura. BAC has been sub-classified into three types: nonmucinous, mucinous, and mixed. 1
Contagious Respiratory Tumours Also known as: Jaagsiekte, Pulmonary Adenomatosis and Adenomatosis - Pulmonary There are two neoplastic conditions which result in contagious respiratory tumours (or contagious lung cancer) in small ruminants: Ovine Pulmonary Adenocarcinoma (also known as ODA, She...
Abnova Human CREB1 Partial ORF (AAH10636.1, 14 a.a. - 101 a.a.) Recombinant Protein with GST-tag at N-terminal 10µg Life Sciences:Protein Biology:Proteins:Proteins A-Z:Proteins
Abnova Human DKFZP586B1621 Full-length ORF (AAH01341, 1 a.a. - 575 a.a.) Recombinant Protein with GST-tag at N-terminal 10µg Life Sciences:Protein Biology:Proteins:Proteins
ABSTRACT: Beaked whales are among the least known group of cetaceans, and information regarding their pathology and parasitology are especially scarce. We describe a case of significant parasitism by a trematode found in the liver of an adult male Hubbs beaked whale Mesoplodon carlhubbsi that stranded in Hokkaido, Japan. Post-mortem examinations revealed a localised area of discolouration restricted to the hilar region of the left hepatic lobe, where spindle-shaped trematodes occupied the dilated and hypertrophic bile ducts. Histologically, the intrahepatic bile ducts were characterised by adenomatous hyperplasia with goblet cell metaplasia of the biliary epithelium. Findings in the adjacent hepatic parenchyma included pseudocarcinomatous ductular reactions obliterating hepatocytes, a histomorphology not previously reported in marine mammals. Morphological identification of the trematode corresponded to Oschmarinella macrorchis, which has only been reported once in a Stejnegers beaked whale M. ...
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These images are intended for educational purposes and may be freely used for such as long as the Papanicolaou Society and the Bethesda System for Reporting Thyroid Cytopathology is credited ...
If youre asking why should a first aider always be present at a cricket game, the answer is that they can make a positive difference if someone is injured.
Clinical treatments for cats with Functional Thyroid Adenomatous Hyperplasia typically include the following three options:. » Daily treatment with an anti-thyroid drug (typically methimazole). The primary problem with this treatment is that it is not a cure. Treatment will be needed to be given every day (one pill given once or twice a day) for the rest of the felines life. Side effects may include vomiting, anorexia, fever, anemia and lethargy.. » Surgical intervention is another effective treatment using a procedure called a "thyroidectomy" (the removal of the thyroid gland). This option is usually selected when only one thyroid lobe is involved. While it offers a cure; it is possible for the hyperthyroidism to re-occur. A feline with kidney disease cannot have this surgery. A possible side effect is hypothyroidism (an underactive thyroid) which will require life-long thyroid supplementation.. » Radioactive Iodine Treatment is a fairly new treatment that provides a permanent cure in 95% ...
Primary cutaneous neuroendocrine carcinoma M8248/1 Apudoma M8249/3 Atypical carcinoid tumor M8250/1 Pulmonary adenomatosis (C34 ... Familial polyposis coli Adenomatosis, NOS M8220/3 Adenocarcinoma in adenomatous polyposis M8221/0 Multiple adenomatous polyps ... diffuse sclerosing M8360/1 Multiple endocrine adenomas Endocrine adenomatosis M8361/0 Juxtaglomerular tumor (C64.9) Reninoma ... fibroma M8967/0 Ossifying renal tumor M8970/3 Hepatoblastoma Embryonal hepatoma M8971/3 Pancreatoblastoma M8972/3 Pulmonary ...
... adenomatosis, pulmonary MeSH C04.557.470.035.215 --- adenomatous polyps MeSH C04.557.470.035.215.100 --- adenomatous polyposis ... pulmonary adenomatosis, ovine MeSH C04.557.470.200.150 --- carcinoma, adenosquamous MeSH C04.557.470.200.165 --- carcinoma, ... pulmonary MeSH C04.588.894.797.520.734 --- pancoast's syndrome MeSH C04.588.894.797.520.867 --- pulmonary blastoma MeSH C04.588 ... pulmonary blastoma MeSH C04.557.435.710 --- rhabdoid tumor MeSH C04.557.435.775 --- sarcoma, endometrial stromal MeSH C04.557. ...
... pulmonary adenomatosis, ovine MeSH C22.836.799 --- scrapie MeSH C22.836.886 --- swayback MeSH C22.836.900 --- visna MeSH ...
... pulmonary adenomatosis, ovine MeSH C02.782.815.800 --- sarcoma, avian MeSH C02.782.930.100 --- alphavirus infections MeSH ... hantavirus pulmonary syndrome MeSH C02.782.147.420.400 --- hemorrhagic fever with renal syndrome MeSH C02.782.147.444 --- ...
... (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious ... It has also been known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma. OPA has been used as an animal model for ... "2.7.9 Ovine pulmonary adenocarcinoma (adenomatosis)". Manual of diagnostic tests and vaccines for terrestrial animals 2016 (PDF ... De Las Heras, M; González, L; Sharp, JM (2003). "Pathology of ovine pulmonary adenocarcinoma". In Fan, Hung. Jaagsiekte Sheep ...
... multiple endocrine adenomatosis - multiple endocrine neoplasia syndrome - multiple endocrine neoplasia type 1 syndrome - ... pulmonary sulcus tumor - PV701 - pyrazine diazohydroxide - pyrazoloacridine - pyroxamide Q10 - QS21 - quadrantectomy R- ...
Morphological Resemblance of Pulmonary Adenomatosis (Jaagsiekte) in Sheep and Certain Cases of Cancer of the Lung in Man. C. ... Morphological Resemblance of Pulmonary Adenomatosis (Jaagsiekte) in Sheep and Certain Cases of Cancer of the Lung in Man ... Morphological Resemblance of Pulmonary Adenomatosis (Jaagsiekte) in Sheep and Certain Cases of Cancer of the Lung in Man ... Morphological Resemblance of Pulmonary Adenomatosis (Jaagsiekte) in Sheep and Certain Cases of Cancer of the Lung in Man ...
... ... Presence of Herpesvirus ovis DNA sequences in cellular DNA from sheep lungs affected with jaagsiekte (pulmonary adenomatosis). ...
Ovine Pulmonary Adenomatosis 1687 words - 7 pages oncogene. JSRV env is a type-1 transmembrane protein composed of surface (SU ...
Pulmonary Adenomatosis, Ovine / metabolism. Pulmonary Surfactant-Associated Protein A / metabolism. Pulmonary Surfactant- ... Woldemeskel M, Tibbo M: Pulmonary adenomatosis and maedi-visna in Ethiopian central highland sheep: a microscopic study. Trop ... 1 adenomatoses pulmonary 2005:2010[pubdate] *count=100 2 results Searchbox Export PDF RSS Email Delete Email this search result ... detection of pulmonary surfactant proteins and retroviral antigens in the lungs of sheep with pulmonary adenomatosis. J Comp ...
Pulmonary adenomatosis. Nairobi sheep disease. Salmonellosis (S. abortus ovis). Scrapie. Maedi-Visna ...
Ovine pulmonary adenomatosis. *Paratuberculosis (Johnes disease). *Porcine reproductive and respiratory syndrome (PRRS) ...
Detection and quantitation of a type D retrovirus gag protein in ovine pulmonary carcinoma (sheep pulmonary adenomatosis) by ... Detection and quantitation of a type D retrovirus gag protein in ovine pulmonary carcinoma (sheep pulmonary adenomatosis) by ... T1 - Detection and quantitation of a type D retrovirus gag protein in ovine pulmonary carcinoma (sheep pulmonary adenomatosis) ... Detection and quantitation of a type D retrovirus gag protein in ovine pulmonary carcinoma (sheep pulmonary adenomatosis) by ...
Pulmonary adenomatosis virus. Pulmonary adenomatosis. Sheep pox and goat pox viruses. Sheep and goat pox. ...
Pulmonary adenomatosis virus. Pulmonary adenomatosis. Sheep pox and goat pox viruses. Sheep and goat pox. ...
En la malformación enquistada de la adenomatosis, el revelado defectuoso de uno de los lóbulos da lugar a la formación de un ... Pulmonaryhypoplasia, http://www.chop.edu/conditions-diseases/pulmonary-hypoplasia. Further Reading. *All Pulmonary Hypoplasia ... Malformación enquistada de la adenomatosis. Los pulmones se componen de cinco lóbulos, con dos encontrados en el pulmón ... Retrieved on April 05, 2020 from https://www.news-medical.net/health/Causes-of-Pulmonary-Hypoplasia.aspx. ...
Ovine pulmonary adenocarcinoma (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious ... It has also been known as sheep pulmonary adenomatosis and ovine pulmonary carcinoma. OPA has been used as an animal model for ... "2.7.9 Ovine pulmonary adenocarcinoma (adenomatosis)". Manual of diagnostic tests and vaccines for terrestrial animals 2016 (PDF ... De Las Heras, M; González, L; Sharp, JM (2003). "Pathology of ovine pulmonary adenocarcinoma". In Fan, Hung. Jaagsiekte Sheep ...
... pulmonary mycoses explanation free. What is pulmonary mycoses? Meaning of pulmonary mycoses medical term. What does pulmonary ... Looking for online definition of pulmonary mycoses in the Medical Dictionary? ... ovine pulmonary adenomatosis. a very chronic progressive pneumonia of sheep and goats caused by a retrovirus. Dyspnea, ... pulmonary malformation. includes accessory lungs, pulmonary hypoplasia, pulmonary agenesis, congenital pulmonary cysts, ...
The post mortem revealed that Cedric had died of sheep pulmonary adenomatosis (SPA). This disease is caused by a virus that ...
Unusual discovery after an examination for abdominal pain: Abernethy 1b malformation and liver Adenomatosis. A case report. J ... a A selective right pulmonary arteriogram showed diffuse reticular pattern on right lower lung, which suggested pulmonary ... Pulmonary arteriovenous fistula: clinical and histologic Spectrum of four cases. J Pathol Transl Med. 2016;50(5):390-3.CrossRef ... Pulmonary arteriovenous malformations and their mimics. Clin Radiol. 2015;70:96-110.CrossRefGoogle Scholar ...
9724476 - Management of liver adenomatosis: results with a conservative surgical approach.. 19247846 - Mcp-1 and mip3-alpha ... 18215276 - Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a c.... 17660726 - ...
A condition characterized by multiple adenomas within an organ or in several related organs Explanation of adenomatosis ... Looking for adenomatosis? Find out information about adenomatosis. ... Pulmonary cancer and adenomatosis in captive wild mammals and birds from the Philadelphia Zoo.. A complicated, metastatic, ... adenomatosis. Also found in: Dictionary, Thesaurus, Medical. adenomatosis. [‚ad·ən‚ō·mə′tō·səs] (medicine) A condition ...
1988) The etiology and pathogenesis of ovine pulmonary carcinoma (sheep pulmonary adenomatosis). Vet. Microbiol. 17:219-236. ... is the causative agent of a contagious lung cancer of sheep known as sheep pulmonary adenomatosis (SPA; also ovine pulmonary ... 1997) Sheep pulmonary adenomatosis: a unique model of retrovirus-associated lung cancer. Trends Microbiol. 5:478-483. ... 1995) Epithelial tumour cells in the lungs of sheep with pulmonary adenomatosis are major sites of replication for Jaagsiekte ...
M. Sozmen, E. Beytut, An Investigation of Growth Factors and Lactoferrin in Naturally Occurring Ovine Pulmonary Adenomatosis, ...
Primary cutaneous neuroendocrine carcinoma M8248/1 Apudoma M8249/3 Atypical carcinoid tumor M8250/1 Pulmonary adenomatosis (C34 ... Familial polyposis coli Adenomatosis, NOS M8220/3 Adenocarcinoma in adenomatous polyposis M8221/0 Multiple adenomatous polyps ... diffuse sclerosing M8360/1 Multiple endocrine adenomas Endocrine adenomatosis M8361/0 Juxtaglomerular tumor (C64.9) Reninoma ... fibroma M8967/0 Ossifying renal tumor M8970/3 Hepatoblastoma Embryonal hepatoma M8971/3 Pancreatoblastoma M8972/3 Pulmonary ...
Epithelial tumour cells in the lungs of sheep with pulmonary adenomatosis are major sites of replication for Jaagsiekte ... Jaagsiekte retrovirus establishes a disseminated infection of the lymphoid tissues of sheep affected by pulmonary adenomatosis ... of Jaagsiekte sheep retrovirus in sheep and goats naturally affected by enzootic nasal tumour or sheep pulmonary adenomatosis. ...
Pulmonary adenomatosis (Jaagsiekte). Exotic. Prohibited organism. Salmonellosis (Salmonella abortus ovis). Not exotic ...
Møller K, Agerholm JS, Ahrens P, Jensen NE, Nielsen TK: Abscess disease, caseous lymphadenitis, and pulmonary adenomatosis in ...
To select a number for mention is not to slight the remainder: transient cerebral ischemic attacks, pulmonary biopsy, ... multiple endocrine adenomatosis, obesity, erythrocytosis with normal blood-gas values, angina without coronaryartery disease, ...
pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.9. 24. non-alcoholic fatty liver disease 9.9. ... MalaCards based summary : Liver Adenomatosis, also known as hepatic adenomatosis, is related to hepatocellular adenoma and ... Articles related to Liver Adenomatosis:. (show top 50) (show all 100) #. Title. Authors. PMID. Year. ... Biological processes related to Liver Adenomatosis according to GeneCards Suite gene sharing:. (show all 13) #. Name. GO ID. ...
  • Identification of Atypic and Classic, Mucinous and Nonmucinous Forms of Ovine Pulmonary Adenocarcinoma (OPA) and TTF1 Marker Expression', Iranian Journal of Veterinary Medicine , 11(3), pp. 279-287. (ac.ir)
  • Congenital broncho-pulmonary malformations [CBM] are rare, essentially presented by congenital lobar emphysema, bronchogenic cysts, pulmonary sequestrations and cystic adenomatoid malformations. (bvsalud.org)
  • Ten cases of BPM have been investigated: five congenitals lobar emphysema, tow pulmonary sequestrations, tow cystic ad nomatoid malformation and one bronchogenic cyst. (bvsalud.org)
  • They are used to evaluate patients in the diagnosis of pulmonary disease, assessment of disease development, or evaluation of the risk of pulmonary complications from surgery. (thefreedictionary.com)
  • After two years, laparoscopic resection of the mass and histopathological examination of the surgical specimen allowed to establish the diagnosis of intra-abdominal extralobar pulmonary sequestration. (bvsalud.org)
  • however, surgical excision is often performed, probably due to the impossibility of attaining diagnosis with non-invasive methods, such as in the present case, in which the lesion appeared in an unusual position for intra-abdominal extralobar pulmonary sequestration. (bvsalud.org)
  • In our case, internal branching linear architecture, lack of enhancement in the peripheral portion of the lesion with internal hemorrhage, and vascular pedicle were well visualized on preoperative magnetic resonance imaging that led to successful preoperative diagnosis of extralobar pulmonary sequestration with hemorrhagic infarction probably due to torsion. (bvsalud.org)
  • LIANG Hua-chun,QI Jing-wei,LIU Shu-ying*,et al.The pathological and RT-PCR diagnosis ofsheep pulmonary adenomatosis [J].Chinese journal of preventive veterinary medicine,2009,(09):443. (paperopen.com)
  • Objective: To describe an unusual clinical presentation of intra-abdominal extralobar pulmonary sequestration in a 2-year, 9 month-old patient and assess diagnostic and treatment aspects of this pathology. (bvsalud.org)
  • An important gene associated with Liver Adenomatosis is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Integrated Breast Cancer Pathway . (malacards.org)
  • En fetalis de los hydrops, el edema severo y peligroso para la vida (hinchazón) se convierte mientras que el líquido aumenta y rodea los pulmones, el abdomen y el corazón del feto. (news-medical.net)
  • We describe a rare case of extralobar pulmonary sequestration with hemorrhagic infarction in a 10-year-old boy who presented with acute abdominal pain and fever. (bvsalud.org)
  • Lung cancer is the main cause of mortality among cancer patients ( 32 ), and the characteristics BAC and SPA have in common suggest that the latter could offer novel insights into pulmonary carcinogenesis. (asm.org)
  • QIN Yong-li,SUN En-cheng,GENG Hong-wei,et al.Production and identification of monoclonal antibodies against VP7 and NS2 of bluetongue virus[J].Chinese journal of preventive veterinary medicine,2011,(09):816. (paperopen.com)
  • WEI Peng,SUN En-cheng,LIU Ni-hong,et al.Preparation and identification of monoclonal antibodies against VP6 and VP7 of bluetongue virus[J].Chinese journal of preventive veterinary medicine,2012,(09):412. (paperopen.com)
  • YANG Tao,XU Qing-yuan,SUN En-cheng,et al.Establishment of a reverse genetics system for bluetongue virus[J].Chinese journal of preventive veterinary medicine,2014,(09):85. (paperopen.com)
  • To study the principal clinic, radiologic and therapeutic of the congenital broncho-pulmonary malformations through ten cases. (bvsalud.org)