Adenoma: A benign epithelial tumor with a glandular organization.Adenoma, Pleomorphic: A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)Adenoma, Villous: An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.Adrenocortical Adenoma: A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.Adenoma, Liver Cell: A benign epithelial tumor of the LIVER.Adenoma, Chromophobe: A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.Growth Hormone-Secreting Pituitary Adenoma: A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Colonic Polyps: Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.ACTH-Secreting Pituitary Adenoma: A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.Adenoma, Acidophil: A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)Colonoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the colon.Adenomatous Polyps: Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)Prolactinoma: A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.Adenoma, Basophil: A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Adenomatous Polyposis Coli: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.Genes, APC: Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.Hyperparathyroidism: A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Colonic Neoplasms: Tumors or cancer of the COLON.Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Adrenal Gland Neoplasms: Tumors or cancer of the ADRENAL GLANDS.Pituitary ACTH Hypersecretion: A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Hyperaldosteronism: A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.Sphenoid Bone: An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Pituitary Gland: A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Hyperparathyroidism, Primary: A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Sella Turcica: A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND.Sigmoidoscopy: Endoscopic examination, therapy or surgery of the sigmoid flexure.Choristoma: A mass of histologically normal tissue present in an abnormal location.Rectal Neoplasms: Tumors or cancer of the RECTUM.Pituitary Apoplexy: The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.Human Growth Hormone: A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Pituitary Hormones: Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.Adenomatous Polyposis Coli Protein: A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.Parathyroidectomy: Excision of one or more of the parathyroid glands.Urethane: Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Adenoma, Bile Duct: A benign tumor of the intrahepatic bile ducts.Prolactin: A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.Colon, Descending: The segment of LARGE INTESTINE between TRANSVERSE COLON and the SIGMOID COLON.
(1/197) Salivary gland tumors in Jordan: a retrospective study of 221 patients.

AIM: To evaluate the types and clinical outcome of salivary gland tumors in Jordan. METHODS: Hospital records of 221 patients (85 women and 136 men) with salivary gland tumors, diagnosed from January 1988 to December 1997 were reviewed. The patients were analyzed according to sex, age, histopathological type and site of the tumor. Survival curves for patients with malignant tumors were constructed using Kaplan-Meier's method. RESULTS: Of the total 221 salivary gland tumors, 155 (70.2%) were parotid tumors, 42 (19%) minor salivary gland tumors, 23 (10.4%) submandibular gland tumors, and a single (0.4%) sublingual gland tumor. Most of the tumors (151, or 68.4%) were classified as benign and 70 (31.6%) were malignant. Men to women ratio was 1.6:1, and the age of the patients ranged from 2 to 81 years. The overall 5 and 10 year-survival rates for the 70 malignant tumors were 67% and 53%, respectively, for all tumor stages. Mucoepidermoid carcinoma had the best, and squamous cell carcinoma the worst 10-year survival rate. Patients treated with surgery and subsequent radiation therapy had better survival rates than those treated with surgery or radiation therapy alone. CONCLUSION: The principal site for salivary gland tumors in Jordan population was the parotid, and the pleo- morphic adenoma the most common pathological finding. Tumor characteristics and survival data for the Jordanian population are comparable to those from western countries.  (+info)

(2/197) Clinically benign parotid tumours: local dissection as an alternative to superficial parotidectomy in selected cases.

In a personal series of 162 tumours, 101 were pleomorphic adenomas 28 of which were removed by elective local extra capsular dissection and 73 by a conventional nerve dissection. There were no recurrences in either group after a mean follow-up 10.3 years, range 3-21 years for local dissection and 8.3 years, range 3-22 years for nerve dissection. Frey's syndrome did not occur after local dissection but was present in 25% of patients after a nerve dissection. Of the 162 parotid lumps, 17 proved to be a carcinoma but only one was deemed suitable for a local removal, a low grade muco epidermoid carcinoma of the accessory lobe and no recurrence has occurred after 8 years. In benign disease, local dissection gives similar results to conventional nerve dissection with less morbidity and confirms that tumour recurrence cannot be ascribed to any properties of the tumour but lies in the hands of the surgeon and depends on the care with which the tumour is removed.  (+info)

(3/197) PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II.

PLAG1, a novel developmentally regulated C2H2 zinc finger gene, is consistently rearranged and overexpressed in pleomorphic adenomas of the salivary glands with 8q12 translocations. In this report, we show that PLAG1 is a nuclear protein that binds DNA in a specific manner. The consensus PLAG1 binding site is a bipartite element containing a core sequence, GRGGC, and a G-cluster, RGGK, separated by seven random nucleotides. DNA binding is mediated mainly via three of the seven zinc fingers, with fingers 6 and 7 interacting with the core and finger 3 with the G-cluster. In transient transactivation assays, PLAG1 specifically activates transcription from its consensus DNA binding site, indicating that PLAG1 is a genuine transcription factor. Potential PLAG1 binding sites were found in the promoter 3 of the human insulin-like growth factor II (IGF-II) gene. We show that PLAG1 binds IGF-II promoter 3 and stimulates its activity. Moreover, IGF-II transcripts derived from the P3 promoter are highly expressed in salivary gland adenomas overexpressing PLAG1. In contrast, they are not detectable in adenomas without abnormal PLAG1 expression nor in normal salivary gland tissue. This indicates a perfect correlation between PLAG1 and IGF-II expression. All of these results strongly suggest that IGF-II is one of the PLAG1 target genes, providing us with the first clue for understanding the role of PLAG1 in salivary gland tumor development.  (+info)

(4/197) Cartilage-specific matrix protein chondromodulin-I is associated with chondroid formation in salivary pleomorphic adenomas: immunohistochemical analysis.

Chondromodulin-I (ChM-I) is a novel cartilage-specific matrix protein. In the growth plates of the long bones, ChM-I was shown to be expressed in mature to upper hypertrophic chondrocytes, and to be deposited in the cartilage matrix. As ChM-I strongly inhibits angiogenesis, cartilage is avascular. Also, ChM-I has bifunctional activity against chondrocyte proliferation. On the other hand, pleomorphic adenomas of the salivary glands frequently have chondroid elements. To elucidate the relationship between chondroid formation and hypovascularity in salivary pleomorphic adenomas, we immunohistochemically examined the expression and localization of ChM-I in 35 cases of this tumor. ChM-I was immunolocalized to the lacunae in the chondroid elements of pleomorphic adenomas (100%). Type II collagen and aggrecan were immunolocalized throughout the matrix around lacuna cells of the chondroid element (100%, 91.7%), and ChM-I was infrequently immunolocalized to the spindle-shaped myoepithelial cells in the myxoid element (37.5%). Fibroblast growth factor-2 was strongly immunolocalized to the lacuna cells in the chondroid element (100%), among the neoplastic myoepithelial cells in the myxoid elements (96.9%), and on the basement membranes around the solid nests of neoplastic myoepithelial cells (71.4%). Although CD34 is a marker of endothelial cells, CD34 was expressed in the endothelial cells in only a few areas around the epithelial elements and in the fibrous element of pleomorphic adenomas. No signals for CD34 were observed in chondroid elements in pleomorphic adenomas (P < 0.001), but a few signals were seen in the myxoid elements (P < 0.05). These findings suggested that lacuna cells and neoplastic myoepithelial cells expressed ChM-I, and that this molecule may play an important role in hypovascularity and chondroid differentiation in pleomorphic adenoma. In conclusion, pleomorphic adenoma expressed ChM-I, which is involved in hypovascularity and chondroid formation in this type of tumor.  (+info)

(5/197) Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature.

Epithelial-myoepithelial tumors of the lung are rare neoplasms whose biological behavior and clinical course still remain to be defined. A case of epithelial-myoepithelial tumor of the lung arising from bronchial mucosa-submucosa and occurring as a polypoid lesion of the upper left bronchus in a 47-year-old man is reported. The tumor did not infiltrate the cartilaginous wall of the bronchus and showed a biphasic histological appearance with a double layering of epithelial and myoepithelial cells. Myoepithelial spindle cells with eosinophilic cytoplasm were also observed. Mitotic figures were very rare and necrosis absent. Immunohistochemical study for epithelial and muscular markers confirmed the presence of a double-cell component in the tumor, namely epithelial and myoepithelial. The patient is alive and well, with no evidence of recurrent or metastatic disease 6 months after surgery. On the basis of the present case and the six previously reported cases, we suggest using the noncommittal term pulmonary epithelial-myoepithelial tumor of unproven malignant potential (PEMTUMP) for this type of neoplasm. In addition, we first introduce p63 as a novel marker for highlighting the myoepithelial cells of the respiratory tract and speculate on the role of these cells in the development of this unusual tumor.  (+info)

(6/197) High-dose-rate endobronchial brachytherapy in endobronchial metastatic malignant chondroid syringoma.

A 65-year-old man with malignant chondroid syringoma (MCS) was found to have pulmonary metastases in the form of multiple pulmonary nodules 4 years after wide excision and adjuvant radiotherapy of a primary abdominal wall tumor. Atelectasis of the lingula due to obstructive endobronchial metastasis, resistant to combination chemotherapy, led us to perform high-dose rate (HDR) endobronchial brachytherapy for the first time in this rare tumor with a favorable response. This case emphasizes the role of HDR brachytherapy as a palliative procedure in endobronchial tumors not responding to other treatment modalities, even those considered to be radioresistant.  (+info)

(7/197) Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma.

Carcinoma ex pleomorphic adenoma (CexPA) is a carcinoma developing within a pre-existing benign pleomorphic adenoma (PA). Here we describe the identification and characterization of a series of genetic events leading to translocation, deletion/amplification, and overexpression of the HMGIC and MDM2 genes in a CexPA at an early stage of development. The tumor had a pseudodiploid stemline karyotype with a del(5)(q22-23q32-33) and a t(10;12)(p15;q14-15). In addition, there were several sidelines with double minute chromosomes (dmin) or homogeneously staining regions (hsr). Fluorescence in situ hybridization (FISH) mapping revealed that the 12q14-15 breakpoint was located centromeric to HMGIC and that the entire gene was juxtaposed to the der(10) chromosome. Detailed analysis of cells with dmin and hsr revealed that HMGIC and MDM2 were deleted from the der(10) and that the dmin and hsr were strongly positive for both genes. Southern blot analysis confirmed that both HMGIC and MDM2 were amplified and that no gross rearrangements of the genes had occurred. Immunostaining revealed that the HMGIC protein was highly overexpressed particularly in the large polymorphic cells within the carcinomatous part of the tumor. These findings suggest that amplification and overexpression of HMGIC and possibly MDM2 might be important genetic events that may contribute to malignant transformation of benign PA.  (+info)

(8/197) Intraosseous pleomorphic adenoma: case report and review of the literature.

Pleomorphic adenoma is the most common neoplasm of the salivary glands, affecting mainly the parotid gland. The preferential intraoral site of this tumor is the palate. A case of a 31-year-old woman with an intraosseous pleomorphic adenoma located in the maxilla (left paramedian region), showing an approximate evolution of one year is reported. The present intraosseous case represents a rare location, with the tumor probably originating from glandular epithelial remnants captured during embryogenesis. In a review of the literature of 142 cases of intragnathic localization (24% in the maxilla) are identified. A slight predominance of women was observed (56%), with 55% of the patients being affected during the 5th to 7th decade of life. The tumors were malignant in 94% of the cases, with special predominance of mucoepidermoid carcinoma (65%). Intraosseous pleomorphic adenomas are rare, with the present patient being the 6th case reported in the literature and the second found in the maxilla. Mean age of the 5 previously reported cases was 58.8 years.  (+info)

*  Pleomorphic adenoma
Though it is classified as a benign tumor, pleomorphic adenomas have the capacity to grow to large proportions and may undergo ... Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation of parenchymatous ... Leonetti JP, Marzo SJ, Petruzzelli GJ, Herr B (Sep 2005). "Recurrent pleomorphic adenoma of the parotid gland". Otolaryngol ... "Histopathology of pleomorphic adenoma in the parotid gland: a prospective unselected series of 100 cases". Laryngoscope. 111 ( ...
*  Carcinoma ex pleomorphic adenoma
Salivary gland Pleomorphic adenoma Di Palma, S. (Jul 2013). "Carcinoma ex pleomorphic adenoma, with particular emphasis on ... Carcinoma ex pleomorphic adenoma, abbreviated ca ex PA, is a type of cancer typically found in the parotid gland. It arises ... Carcinoma ex pleomorphic adenoma is diagnosed by examining it under the microscope with consideration of the individual history ... In approximately 75% of cases ca ex PAs arise in a pleomorphic adenoma that is apparent when the tumour is excised. In the ...
*  Index of oral health and dental articles
Pleomorphic adenoma • Pleurodont • Plica fimbriata • Polk E. Akers • Polymorphous low-grade adenocarcinoma • Polynoxylin • ... Canalicular adenoma • Canine tooth • Cantilever mechanics • Carbon dioxide laser • Caries vaccine • Carnassial • Case School of ...
*  Catenin
Summary: Associated Cancers: colorectal and ovarian cancer; pilomatrixoma; medulloblastoma; pleomorphic adenomas; malignant ... pleomorphic adenomas, and malignant mesothelioma. While less is known about the exact mechanism of α-catenin, its presence in ... "The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the β-catenin signaling pathway". ...
*  Warthin's tumor
Pleomorphic adenoma Witt, Robert L., ed. (2005). "Chapter 9 "Benign tumors, cysts, and tumor-like conditions of the salivary ... Though much less likely to occur than pleomorphic adenoma, Warthin's tumor is the second most common benign parotid tumor. Its ...
*  Ceruminous adenoma
... Ceruminous pleomorphic adenoma Ceruminous syringocystadenoma papilliferum All of the tumors are ... Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V (March-April 2008). "Primary pleomorphic adenoma of the ... A ceruminous adenoma (also known as adenoma of the ceruminous gland and ceruminoma) is a benign glandular neoplasm which arises ... Other tumors which need to be excluded include a neuroendocrine adenoma of the middle ear (middle ear adenoma), paraganglioma, ...
*  Complex and mixed tumor
Examples include pleomorphic adenoma and Mixed Müllerian tumor. Pleomorphism Mixed tumor "mixed tumor - definition of mixed ...
*  Krause's glands
Lacrimal Gland Histology Pleomorphic adenoma of Krause's gland. ...
*  Tenascin X
2008). "Tenascin and fibronectin expression in carcinoma ex pleomorphic adenoma". Appl. Immunohistochem. Mol. Morphol. 16 (1): ...
*  Salivary duct carcinoma
About 40-60% of SDC arise in pleomorphic adenomas. Most, if not all, SDCs express androgen receptor by immunohistochemistry. ... "Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and ...
*  Epithelial-myoepithelial carcinoma
The histologic differential diagnosis includes adenoid cystic carcinoma and pleomorphic adenoma. They generally have a good ...
*  Keratin 8
8, 17 and vimentin in pleomorphic adenoma of the salivary glands]". Arkh. Patol. 51 (10): 28-35. PMID 2482017. Eichbaum QG, ...
*  Parotidectomy
The most common form of benign parotid neoplasms are pleomorphic adenomas. The most common form of malignant parotid neoplasms ...
*  Ceruminous gland
The benign tumors include ceruminous adenoma, ceruminous pleomorphic adenoma, and ceruminous syringocystadenoma papilliferum. ...
*  NFIB (gene)
1998). "Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas". Oncogene. 16 (7): 865 ...
*  Polymorphous low-grade adenocarcinoma
Microscopically, its histology can be confused with an adenoid cystic carcinoma and a pleomorphic adenoma. PLGAs are treated ...
*  PLAG1
"PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using ... Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is ... Voz ML, Agten NS, Van de Ven WJ, Kas K (2000). "PLAG1, the main translocation target in pleomorphic adenoma of the salivary ... in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter". Oncogene. 16 (11 ...
*  HMGA2
... and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma". Am. J. Pathol. 160 (2): 433-40. doi:10.1016/S0002-9440 ... The same mutations that lead to pituitary adenomas in mice can be found in similar cancers in humans. Its presence is ... Fedele M, Pierantoni GM, Visone R, Fusco A (September 2006). "Critical role of the HMGA2 gene in pituitary adenomas". Cell ... "Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas". Oncogene. 21 (20): 3190-8. doi: ...
*  Grover Cleveland
Other suggestions included ameloblastoma or a benign salivary mixed tumor (also known as a pleomorphic adenoma). In the 1980s, ...
*  Canalicular adenoma
In addition to pleomorphic adenoma, the two are the most common tumors of the upper lip. In 95% of cases, canalicular adenoma ... Canalicular adenoma is most likely to occur in older adults around 70 years of age. There is a predilection for gender with ... Canalicular adenoma is characterized as a slow growing, painless swelling, whose diameter can be up to 2 cm. It can be normal ... Canalicular adenoma is a type of benign salivary gland tumor that occurs most often in minor salivary glands. ...
*  Myxoid tumor
Myxoid leiomyosarcoma Myxoid liposarcoma Lipoblastoma Myxofibrosarcoma Myxoid cortical adenoma Pleomorphic adenoma ...
*  List of OMIM disorder codes
PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, salivary gland pleomorphic; 181030; PLAG1 Adenomatous polyposis ... TCF4 Pituitary adenoma, ACTH-secreting; 219090; AIP Pituitary adenoma, growth hormone-secreting; 102200; AIP Pituitary adenoma ... EIF2B4 Leydig cell adenoma, somatic, with precocious puberty; 176410; LHCGR Leydig cell hypoplasia with hypergonadotropic ... SCN4A Parathyroid adenoma with cystic changes; 145001; HRPT2 Parathyroid carcinoma; 608266; HRPT2 Parietal foramina 1; 168500; ...
*  Sialoblastoma
It is important that other tumors such as pleomorphic adenoma, basal cell adenoma, adenoid cystic carcinoma, and teratoma be ... "congenital pleomorphic adenoma"). A clinicopathologic, immunohistochemical and ultrastructural study of nine cases". Am J Surg ... It has previously been referred to as congenital basal cell adenoma, embryoma, or basaloid adenocarcinoma. It is an extremely ... Seifert, G.; Donath, K. (1997). "The congenital basal cell adenoma of salivary glands. Contribution to the differential ...
*  Ectomesenchymal chondromyxoid tumor
They included pleomorphic adenoma, myoepithelioma, myxoid neurofibroma, neurothekeoma (nerve sheath myxoma), chondroid ...
*  Parotid gland
The most common of these include pleomorphic adenoma (70% of tumors, affecting predominantly females (60%)) and Warthin tumor ( ... Other malignant tumors of the parotid gland include acinic cell carcinoma, carcinoma expleomorphic adenoma, adenocarcinoma ( ...
*  Neonatal diabetes mellitus
... pleomorphic adenoma gene-like 1). PLAG1 is a transcription regulator of the type 1 receptor for pituitary adenylated cyclase- ...
Recurrent Pleomorphic Adenoma of Submandibular Region  Recurrent Pleomorphic Adenoma of Submandibular Region
Metastasizing pleomorphic adenoma is a rarely detected form of clinic antity [2,3]. According to the World… ... Pleomorphic adenoma is the most common salivary gland tumor on the head and neck region [1]. ... Pleomorphic adenoma is the most common salivary gland tumor on the head and neck region [1]. Metastasizing pleomorphic adenoma ... of the metastazing pleomorphic adenoma is related with previous pleomorphic adenoma. ...
more infohttps://medium.com/@ScholArena/recurrent-pleomorphic-adenoma-of-submandibular-region-f27100c7ba87
Pleomorphic adenoma - right parotid | Radiology Case | Radiopaedia.org  Pleomorphic adenoma - right parotid | Radiology Case | Radiopaedia.org
Pleomorphic adenomas are the most common salivary gland tumours. This case was donated to Radiopaedia.org by Radswiki.net ... MRI and PET images demonstrate a right parotid pleomorphic adenoma. ... MRI and PET images demonstrate a right parotid pleomorphic adenoma. Pleomorphic adenomas are the most common salivary gland ...
more infohttps://radiopaedia.org/cases/pleomorphic-adenoma-right-parotid
Pleomorphic adenoma - Wikipedia  Pleomorphic adenoma - Wikipedia
Though it is classified as a benign tumor, pleomorphic adenomas have the capacity to grow to large proportions and may undergo ... Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation of parenchymatous ... Leonetti JP, Marzo SJ, Petruzzelli GJ, Herr B (Sep 2005). "Recurrent pleomorphic adenoma of the parotid gland". Otolaryngol ... "Histopathology of pleomorphic adenoma in the parotid gland: a prospective unselected series of 100 cases". Laryngoscope. 111 ( ...
more infohttps://en.wikipedia.org/wiki/Pleomorphic_adenoma
Lymphatic vascular density and lymphangiogenesis during tumour progression of carcinoma ex pleomorphic adenoma | Journal of...  Lymphatic vascular density and lymphangiogenesis during tumour progression of carcinoma ex pleomorphic adenoma | Journal of...
Lymphatic vascular density and lymphangiogenesis during tumour progression of carcinoma ex pleomorphic adenoma ... Lymphatic vascular density and lymphangiogenesis during tumour progression of carcinoma ex pleomorphic adenoma ... and 10 of pleomorphic adenoma (PA) without malignant transformation, lymphatic vessels and proliferating cells were detected ... and lymph vessel endothelial proliferation in a series of carcinoma ex pleomorphic adenoma (CXPA) that represents the tumour in ...
more infohttp://jcp.bmj.com/content/60/9/995
Synchronous pleomorphic adenomas of the major salivary glands:...  Synchronous pleomorphic adenomas of the major salivary glands:...
Synchronous pleomorphic adenomas of the major salivary glands: a case report.: The presentation of multiple distinct tumors in ... Synchronous pleomorphic adenomas of the major salivary glands: a case report.. Authors * Nagler, R M ... We report the case of a female patient who was diagnosed with pleomorphic adenomas in the right parotid and submandibular ... pleomorphic adenomas have been diagnosed simultaneously as well. ...
more infohttps://www.mysciencework.com/publication/show/synchronous-pleomorphic-adenomas-major-salivary-glands-case-report-25d8f3c0
Pleomorphic Adenoma - Benign Neoplasm - Salivary Gland Neoplasm  Pleomorphic Adenoma - Benign Neoplasm - Salivary Gland Neoplasm
A pleomorphic adenoma is a benign neoplasm that forms in the salivary gland. Although they start out benign they do have the ... While pleomorphic adenoma can occur at any age, they are most commonly diagnosed between the ages of 43 - 46. Pleomorphic ... A pleomorphic adenoma is a benign neoplasm that forms in the salivary gland. Although they start out benign they do have the ... Treatment of pleomorphic adenoma depends on the size, location and stage of the tumor. Also, if it is benign or malignant tumor ...
more infohttps://www.knowcancer.com/oncology/pleomorphic-adenoma/
Carcinoma ex Pleomorphic Adenoma of the Nasal Cavity | SpringerLink  Carcinoma ex Pleomorphic Adenoma of the Nasal Cavity | SpringerLink
... pleomorphic adenoma or PA); it accounts for approximately 3-4% of all salivary gland n ... Carcinoma ex pleomorphic adenoma (CXPA) is a malignant epithelial neoplasm arising in a benign mixed tumor (i.e., ... Carcinoma ex pleomorphic adenoma (CXPA) is a malignant epithelial neoplasm arising in a benign mixed tumor (i.e., pleomorphic ... Carcinoma ex-pleomorphic adenoma of the nasal cavity: a report of two cases. J Laryngol Otol. 1995;109:677-9.PubMedCrossRef ...
more infohttps://link.springer.com/article/10.1007%2Fs12105-011-0262-2
Treatment for Pleomorphic Adenoma | Healthy Living  Treatment for Pleomorphic Adenoma | Healthy Living
Treatment for Pleomorphic Adenoma. by Lee Morgan; Updated September 30, 2017 Related Articles. *Exercise Tips for Developing ... A pleomorphic adenoma is a benign tumor in the salivary glands that appears as a firm and painless mass. In rare cases these ... The most common and effective treatment for pleomorphic adenoma is a complete surgical excision of the tumor itself, according ... The WJSO reports that studies have shown a 6 to 7 percent recurrence rate for patients with benign pleomorphic adenoma. ...
more infohttps://healthyliving.azcentral.com/treatment-for-pleomorphic-adenoma-12215114.html
Pleomorphic Adenoma of the Lateral Nasal Wall-A case report.  Pleomorphic Adenoma of the Lateral Nasal Wall-A case report.
We report a rare case of pleomorphic adenoma arising from the lateral nasal wall. PATIENT AND METHOD: A 23year old woman ... AIM/BACKGROUND: We report a rare case of pleomorphic adenoma arising from the lateral nasal wall. PATIENT AND METHOD: A 23year ... The diagnosis, clinical behaviour and treatment of pleomorphic adenoma of the lateral nasal wall are discussed from a review of ... which are histological characteristics of pleomorphic adenoma. CONCLUSIONS: Her post-operative clinic visits were uneventful, ...
more infohttp://www.biomedsearch.com/nih/Pleomorphic-Adenoma-Lateral-Nasal-Wall/19767912.html
Pleomorphic adenoma hard palate - Things You Didnt Know  Pleomorphic adenoma hard palate - Things You Didn't Know
Tavarez on pleomorphic adenoma hard palate: You clearly have a thyroid problem, and this needs to be discussed in context of ... Pleomorphic (Definition) We use the term pleomorphic often in pathology; it literally means "many shapes". Pleomorphic cells in ... I ve pleomorphic adenoma in parotid gland.dr performed fnac..does fnac spread tumor cells..scared.size is 1.5cm.entire gland ... Spread not likely: Pleomorphic adenoma is benign and there is minimal risk of spread with a fine needle aspirate. Removal is ...
more infohttps://www.healthtap.com/topics/pleomorphic-adenoma-hard-palate
Pleomorphic adenoma of the parotid gland - ARRS GoldMiner®  Pleomorphic adenoma of the parotid gland - ARRS GoldMiner®
Pleomorphic adenoma of the parotid gland.. Non-contrast studies -- Sagittal SE T1-weighted MR image reveals a well- ...
more infohttp://goldminer.arrs.org/inline-eurorad-link.php?id=241277&n=0
Pleomorphic adenoma of the parotid gland - ARRS GoldMiner®  Pleomorphic adenoma of the parotid gland - ARRS GoldMiner®
Pleomorphic adenoma of the parotid gland.. Non-contrast studies -- Coronal fat-suppressed FSE T2-weighted MR image reveals a ...
more infohttp://goldminer.arrs.org/inline-eurorad-link.php?id=241279&n=0
Unusual Metastases from a Pleomorphic Adenoma of the Parotid Gland: A Case and Literatures Review  Unusual Metastases from a Pleomorphic Adenoma of the Parotid Gland: A Case and Literature's Review
Conclusion: Metastatizing pleomorphic adenoma is a rare pathologic situation but, in case of swelling or lump appearance in ... Metastasizing pleomorphic adenomas has rarely been reported. No histologic or molecular parameters exist at the present time ... A 54-year-old woman had a superficial left parotidectomy with facial nerve preservation for pleomorphic adenoma. She developed ... patients with pleomorphic adenoma history, it should be taken in mind. ...
more infohttps://www.scirp.org/journal/paperinformation.aspx?paperid=39302
Carcinoma ex pleomorphic adenoma - Wikipedia  Carcinoma ex pleomorphic adenoma - Wikipedia
Salivary gland Pleomorphic adenoma Di Palma, S. (Jul 2013). "Carcinoma ex pleomorphic adenoma, with particular emphasis on ... Carcinoma ex pleomorphic adenoma, abbreviated ca ex PA, is a type of cancer typically found in the parotid gland. It arises ... Carcinoma ex pleomorphic adenoma is diagnosed by examining it under the microscope with consideration of the individual history ... In approximately 75% of cases ca ex PAs arise in a pleomorphic adenoma that is apparent when the tumour is excised. In the ...
more infohttps://en.wikipedia.org/wiki/Carcinoma_ex_pleomorphic_adenoma
pleomorphic adenoma with extensive squamous metaplasia - Humpath.com - Human pathology  pleomorphic adenoma with extensive squamous metaplasia - Humpath.com - Human pathology
Synopsis pleomorphic adenoma with extensive squamous metaplasia +/- keratin cyst formations squamous metaplasia, sometimes with ... Home , F. Pathology by regions , Head and neck , Head , Mouth - Oral cavity , Salivary glands , pleomorphic adenoma with ... pleomorphic adenoma with extensive squamous metaplasia +/- keratin cyst formations. * squamous metaplasia, sometimes with the ... Pleomorphic adenoma with extensive squamous metaplasia and keratin cyst formations in minor salivary gland: a case report. 2011 ...
more infohttps://humpath.com/spip.php?article23113
pleomorphic adenoma with extensive squamous metaplasia - Humpath.com - Human pathology  pleomorphic adenoma with extensive squamous metaplasia - Humpath.com - Human pathology
Synopsis pleomorphic adenoma with extensive squamous metaplasia +/- keratin cyst formations squamous metaplasia, sometimes with ... Home , F. Pathology by regions , Head and neck , Head , Mouth - Oral cavity , Salivary glands , pleomorphic adenoma with ... pleomorphic adenoma with extensive squamous metaplasia +/- keratin cyst formations. * squamous metaplasia, sometimes with the ... Pleomorphic adenoma with extensive squamous metaplasia and keratin cyst formations in minor salivary gland: a case report. 2011 ...
more infohttp://www.humpath.com/spip.php?article23113
Case Study 43 Pleomorphic Adenoma of Lacrimal Gland | Springer for Research & Development  Case Study 43 Pleomorphic Adenoma of Lacrimal Gland | Springer for Research & Development
Harrie R.P., Kendall C.J. (2014) Case Study 43 Pleomorphic Adenoma of Lacrimal Gland. In: Clinical Ophthalmic Echography. ...
more infohttps://rd.springer.com/chapter/10.1007/978-1-4614-7082-3_43
Pleomorphic Adenoma of the Parotid: Extracapsular Dissection Compared with Superficial Parotidectomy-A 10-Year Retrospective...  Pleomorphic Adenoma of the Parotid: Extracapsular Dissection Compared with Superficial Parotidectomy-A 10-Year Retrospective...
Pleomorphic Adenoma of the Parotid: Extracapsular Dissection Compared with Superficial Parotidectomy-A 10-Year Retrospective ... The authors carried out a retrospective cohort study of 198 patients with pleomorphic adenomas of the parotid gland. ... Extracapsular dissection may be considered the treatment of choice for pleomorphic adenomas located in the superficial portion ... rates and effectiveness of extracapsular dissection compared with superficial parotidectomy for pleomorphic adenomas of the ...
more infohttps://www.hindawi.com/journals/tswj/2014/564053/abs/
Parapharyngeal chordoma: A diagnostic challenge and potential mimic of pleomorphic adenoma on fine-needle aspiration cytology -...  Parapharyngeal chordoma: A diagnostic challenge and potential mimic of pleomorphic adenoma on fine-needle aspiration cytology -...
A review of the FNA cytologic features of this case of chordoma and of 17 consecutive cases of pleomorphic adenoma found that ... Parapharyngeal chordoma: A diagnostic challenge and potential mimic of pleomorphic adenoma on fine-needle aspiration cytology. ... A review of the literature found no previous instances in which chordomas mimicked pleomorphic adenoma on FNA. However, since ... intensely metachromatic material led to an initial diagnosis of pleomorphic adenoma. Review of the patient's prior pathology ...
more infohttp://onlinelibrary.wiley.com/doi/10.1002/dc.21855/abstract
Lacrimal gland pleomorphic adenoma and malignant epithelial tumours: clinical and imaging differences | British Journal of...  Lacrimal gland pleomorphic adenoma and malignant epithelial tumours: clinical and imaging differences | British Journal of...
Aims To investigate the clinical and imaging features of primary and recurrent lacrimal gland pleomorphic adenoma (LGPA), as ... Lacrimal gland pleomorphic adenoma and malignant epithelial tumours: clinical and imaging differences ... Lacrimal gland pleomorphic adenoma and malignant epithelial tumours: clinical and imaging differences ...
more infohttps://bjo.bmj.com/content/103/2/264
  • In 8 cases of early CXPA (intracapsular and minimally invasive tumours), 8 of advanced CXPA (widely invasive tumours) and 10 of pleomorphic adenoma (PA) without malignant transformation, lymphatic vessels and proliferating cells were detected using the antibodies D2-40 and Ki-67 respectively. (bmj.com)
  • Pleomorphic Adenoma of the Lateral Nasal Wall-A case report. (biomedsearch.com)
  • AIM/BACKGROUND: We report a rare case of pleomorphic adenoma arising from the lateral nasal wall. (biomedsearch.com)
  • There was associated expansion of the cavity with displacement of the nasal septum and thinning of the medial wall of the right maxillary antrum adjacent to it.The microscopic finding showed a lobular duct-like structure within a loose chondromyxoid stroma,which are histological characteristics of pleomorphic adenoma. (biomedsearch.com)
  • If this is in your thyroid it could well be an adenoma , but without a biopsy of some type you will not know! (healthtap.com)