A benign epithelial tumor with a glandular organization.
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.
A benign epithelial tumor of the LIVER.
A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.
A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.
A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.
A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)
A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.
A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)
Tumors or cancers of the ADRENAL CORTEX.
A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.
A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
Tumors or cancer of the SALIVARY GLANDS.
Tumors or cancer of the COLON.
Tumors or cancer of the INTESTINES.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Tumors or cancer of the ADRENAL GLANDS.
A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.
Tumors or cancer of the PAROTID GLAND.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.
An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).
Tumors or cancer of the DUODENUM.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
A malignant epithelial tumor with a glandular organization.
A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
Tumors or cancer of the THYROID GLAND.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND.
Endoscopic examination, therapy or surgery of the sigmoid flexure.
A mass of histologically normal tissue present in an abnormal location.
Tumors or cancer of the RECTUM.
The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.
A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.
A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.
Excision of one or more of the parathyroid glands.
Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
A benign tumor of the intrahepatic bile ducts.
A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.
The segment of LARGE INTESTINE between TRANSVERSE COLON and the SIGMOID COLON.

Salivary gland tumors in Jordan: a retrospective study of 221 patients. (1/197)

AIM: To evaluate the types and clinical outcome of salivary gland tumors in Jordan. METHODS: Hospital records of 221 patients (85 women and 136 men) with salivary gland tumors, diagnosed from January 1988 to December 1997 were reviewed. The patients were analyzed according to sex, age, histopathological type and site of the tumor. Survival curves for patients with malignant tumors were constructed using Kaplan-Meier's method. RESULTS: Of the total 221 salivary gland tumors, 155 (70.2%) were parotid tumors, 42 (19%) minor salivary gland tumors, 23 (10.4%) submandibular gland tumors, and a single (0.4%) sublingual gland tumor. Most of the tumors (151, or 68.4%) were classified as benign and 70 (31.6%) were malignant. Men to women ratio was 1.6:1, and the age of the patients ranged from 2 to 81 years. The overall 5 and 10 year-survival rates for the 70 malignant tumors were 67% and 53%, respectively, for all tumor stages. Mucoepidermoid carcinoma had the best, and squamous cell carcinoma the worst 10-year survival rate. Patients treated with surgery and subsequent radiation therapy had better survival rates than those treated with surgery or radiation therapy alone. CONCLUSION: The principal site for salivary gland tumors in Jordan population was the parotid, and the pleo- morphic adenoma the most common pathological finding. Tumor characteristics and survival data for the Jordanian population are comparable to those from western countries.  (+info)

Clinically benign parotid tumours: local dissection as an alternative to superficial parotidectomy in selected cases. (2/197)

In a personal series of 162 tumours, 101 were pleomorphic adenomas 28 of which were removed by elective local extra capsular dissection and 73 by a conventional nerve dissection. There were no recurrences in either group after a mean follow-up 10.3 years, range 3-21 years for local dissection and 8.3 years, range 3-22 years for nerve dissection. Frey's syndrome did not occur after local dissection but was present in 25% of patients after a nerve dissection. Of the 162 parotid lumps, 17 proved to be a carcinoma but only one was deemed suitable for a local removal, a low grade muco epidermoid carcinoma of the accessory lobe and no recurrence has occurred after 8 years. In benign disease, local dissection gives similar results to conventional nerve dissection with less morbidity and confirms that tumour recurrence cannot be ascribed to any properties of the tumour but lies in the hands of the surgeon and depends on the care with which the tumour is removed.  (+info)

PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. (3/197)

PLAG1, a novel developmentally regulated C2H2 zinc finger gene, is consistently rearranged and overexpressed in pleomorphic adenomas of the salivary glands with 8q12 translocations. In this report, we show that PLAG1 is a nuclear protein that binds DNA in a specific manner. The consensus PLAG1 binding site is a bipartite element containing a core sequence, GRGGC, and a G-cluster, RGGK, separated by seven random nucleotides. DNA binding is mediated mainly via three of the seven zinc fingers, with fingers 6 and 7 interacting with the core and finger 3 with the G-cluster. In transient transactivation assays, PLAG1 specifically activates transcription from its consensus DNA binding site, indicating that PLAG1 is a genuine transcription factor. Potential PLAG1 binding sites were found in the promoter 3 of the human insulin-like growth factor II (IGF-II) gene. We show that PLAG1 binds IGF-II promoter 3 and stimulates its activity. Moreover, IGF-II transcripts derived from the P3 promoter are highly expressed in salivary gland adenomas overexpressing PLAG1. In contrast, they are not detectable in adenomas without abnormal PLAG1 expression nor in normal salivary gland tissue. This indicates a perfect correlation between PLAG1 and IGF-II expression. All of these results strongly suggest that IGF-II is one of the PLAG1 target genes, providing us with the first clue for understanding the role of PLAG1 in salivary gland tumor development.  (+info)

Cartilage-specific matrix protein chondromodulin-I is associated with chondroid formation in salivary pleomorphic adenomas: immunohistochemical analysis. (4/197)

Chondromodulin-I (ChM-I) is a novel cartilage-specific matrix protein. In the growth plates of the long bones, ChM-I was shown to be expressed in mature to upper hypertrophic chondrocytes, and to be deposited in the cartilage matrix. As ChM-I strongly inhibits angiogenesis, cartilage is avascular. Also, ChM-I has bifunctional activity against chondrocyte proliferation. On the other hand, pleomorphic adenomas of the salivary glands frequently have chondroid elements. To elucidate the relationship between chondroid formation and hypovascularity in salivary pleomorphic adenomas, we immunohistochemically examined the expression and localization of ChM-I in 35 cases of this tumor. ChM-I was immunolocalized to the lacunae in the chondroid elements of pleomorphic adenomas (100%). Type II collagen and aggrecan were immunolocalized throughout the matrix around lacuna cells of the chondroid element (100%, 91.7%), and ChM-I was infrequently immunolocalized to the spindle-shaped myoepithelial cells in the myxoid element (37.5%). Fibroblast growth factor-2 was strongly immunolocalized to the lacuna cells in the chondroid element (100%), among the neoplastic myoepithelial cells in the myxoid elements (96.9%), and on the basement membranes around the solid nests of neoplastic myoepithelial cells (71.4%). Although CD34 is a marker of endothelial cells, CD34 was expressed in the endothelial cells in only a few areas around the epithelial elements and in the fibrous element of pleomorphic adenomas. No signals for CD34 were observed in chondroid elements in pleomorphic adenomas (P < 0.001), but a few signals were seen in the myxoid elements (P < 0.05). These findings suggested that lacuna cells and neoplastic myoepithelial cells expressed ChM-I, and that this molecule may play an important role in hypovascularity and chondroid differentiation in pleomorphic adenoma. In conclusion, pleomorphic adenoma expressed ChM-I, which is involved in hypovascularity and chondroid formation in this type of tumor.  (+info)

Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature. (5/197)

Epithelial-myoepithelial tumors of the lung are rare neoplasms whose biological behavior and clinical course still remain to be defined. A case of epithelial-myoepithelial tumor of the lung arising from bronchial mucosa-submucosa and occurring as a polypoid lesion of the upper left bronchus in a 47-year-old man is reported. The tumor did not infiltrate the cartilaginous wall of the bronchus and showed a biphasic histological appearance with a double layering of epithelial and myoepithelial cells. Myoepithelial spindle cells with eosinophilic cytoplasm were also observed. Mitotic figures were very rare and necrosis absent. Immunohistochemical study for epithelial and muscular markers confirmed the presence of a double-cell component in the tumor, namely epithelial and myoepithelial. The patient is alive and well, with no evidence of recurrent or metastatic disease 6 months after surgery. On the basis of the present case and the six previously reported cases, we suggest using the noncommittal term pulmonary epithelial-myoepithelial tumor of unproven malignant potential (PEMTUMP) for this type of neoplasm. In addition, we first introduce p63 as a novel marker for highlighting the myoepithelial cells of the respiratory tract and speculate on the role of these cells in the development of this unusual tumor.  (+info)

High-dose-rate endobronchial brachytherapy in endobronchial metastatic malignant chondroid syringoma. (6/197)

A 65-year-old man with malignant chondroid syringoma (MCS) was found to have pulmonary metastases in the form of multiple pulmonary nodules 4 years after wide excision and adjuvant radiotherapy of a primary abdominal wall tumor. Atelectasis of the lingula due to obstructive endobronchial metastasis, resistant to combination chemotherapy, led us to perform high-dose rate (HDR) endobronchial brachytherapy for the first time in this rare tumor with a favorable response. This case emphasizes the role of HDR brachytherapy as a palliative procedure in endobronchial tumors not responding to other treatment modalities, even those considered to be radioresistant.  (+info)

Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma. (7/197)

Carcinoma ex pleomorphic adenoma (CexPA) is a carcinoma developing within a pre-existing benign pleomorphic adenoma (PA). Here we describe the identification and characterization of a series of genetic events leading to translocation, deletion/amplification, and overexpression of the HMGIC and MDM2 genes in a CexPA at an early stage of development. The tumor had a pseudodiploid stemline karyotype with a del(5)(q22-23q32-33) and a t(10;12)(p15;q14-15). In addition, there were several sidelines with double minute chromosomes (dmin) or homogeneously staining regions (hsr). Fluorescence in situ hybridization (FISH) mapping revealed that the 12q14-15 breakpoint was located centromeric to HMGIC and that the entire gene was juxtaposed to the der(10) chromosome. Detailed analysis of cells with dmin and hsr revealed that HMGIC and MDM2 were deleted from the der(10) and that the dmin and hsr were strongly positive for both genes. Southern blot analysis confirmed that both HMGIC and MDM2 were amplified and that no gross rearrangements of the genes had occurred. Immunostaining revealed that the HMGIC protein was highly overexpressed particularly in the large polymorphic cells within the carcinomatous part of the tumor. These findings suggest that amplification and overexpression of HMGIC and possibly MDM2 might be important genetic events that may contribute to malignant transformation of benign PA.  (+info)

Intraosseous pleomorphic adenoma: case report and review of the literature. (8/197)

Pleomorphic adenoma is the most common neoplasm of the salivary glands, affecting mainly the parotid gland. The preferential intraoral site of this tumor is the palate. A case of a 31-year-old woman with an intraosseous pleomorphic adenoma located in the maxilla (left paramedian region), showing an approximate evolution of one year is reported. The present intraosseous case represents a rare location, with the tumor probably originating from glandular epithelial remnants captured during embryogenesis. In a review of the literature of 142 cases of intragnathic localization (24% in the maxilla) are identified. A slight predominance of women was observed (56%), with 55% of the patients being affected during the 5th to 7th decade of life. The tumors were malignant in 94% of the cases, with special predominance of mucoepidermoid carcinoma (65%). Intraosseous pleomorphic adenomas are rare, with the present patient being the 6th case reported in the literature and the second found in the maxilla. Mean age of the 5 previously reported cases was 58.8 years.  (+info)

Aims: To assess lymphatic vascular density (LVD) and lymph vessel endothelial proliferation in a series of carcinoma ex pleomorphic adenoma (CXPA) that represents the tumour in the different carcinogenesis phases and tumour progression.. Methods: In 8 cases of early CXPA (intracapsular and minimally invasive tumours), 8 of advanced CXPA (widely invasive tumours) and 10 of pleomorphic adenoma (PA) without malignant transformation, lymphatic vessels and proliferating cells were detected using the antibodies D2-40 and Ki-67 respectively.. Results: Comparing early tumours with advanced ones, LVD was not significantly different at the tumour margin. In contrast, regarding intratumoural lymphatics, PA without malignant transformation and early CXPA contained rare, if any, lymph vessels, whereas in widely invasive carcinomas they were more numerous. However, neither intratumoural nor peritumoural LVD were increased in comparison to adjacent normal salivary gland tissue. In no case did dual ...
TY - JOUR. T1 - Concurrent cytogenetic, interphase fluorescence in situ hybridization and DNA flow cytometric analyses of a carcinoma ex-pleomorphic adenoma of parotid gland. AU - El-Naggar, Adel K.. AU - Lovell, Mercedes. AU - Callender, David L.. AU - Ordonez, Nelson G.. AU - Killary, Ann M.. PY - 1998/12/1. Y1 - 1998/12/1. N2 - We report the cytogenetic, fluorescence in situ hybridization (FISH), and DNA ploidy analyses of a high grade carcinoma ex-pleomorphic adenoma of the submandibular gland. Our overall combined analyses showed a marked DNA aneuploidy and numerical abnormalities involving all chromosomes. Cytogenetic analysis revealed a near tetraploid modal chromosomal number with tetraploid loss of chromosomes Y, 1, 6, 9, 11, 14, 15, 17, and 19-21 and hypertetraploid gain of chromosomes 7, 8, and 22. The structural abnormalities included der(1;14)(q10;q10),del(6)(q15q34),+del(6)(q15q34),+der(8)t(1;8)(q12;q12.2),de r(9;19)(q10;q10),add(14)(p11.2),i(20)(q10),der(21)t(8;21)(q11.2;q22.3), ...
TY - JOUR. T1 - Salivary gland-type mixed tumor (pleomorphic adenoma) of the lung. AU - Carretta, Angelo. AU - Libretti, Lidia. AU - Taccagni, Gianluca. AU - Zannini, Piero. PY - 2004/12. Y1 - 2004/12. N2 - Primary pleomorphic adenomas of the respiratory tract are rare tumors. They usually originate from the bronchial glands, but may also be unrelated to the bronchial tract and be localized in the pulmonary parenchyma. These salivary-gland type neoplasms have peculiar histological and clinical features: they usually behave as low-grade malignant neoplasms, but may also have more aggressive features. The diagnostic and therapeutic approach in a patient with a pulmonary pleomorphic adenoma is described.. AB - Primary pleomorphic adenomas of the respiratory tract are rare tumors. They usually originate from the bronchial glands, but may also be unrelated to the bronchial tract and be localized in the pulmonary parenchyma. These salivary-gland type neoplasms have peculiar histological and clinical ...
TY - JOUR. T1 - Pleomorphic adenoma of nasal septum. T2 - A rare case. AU - Shetty, Shama. AU - Nayak, Dipak Ranjan. AU - Jaiprakash, Padmapriya. PY - 2018/1/1. Y1 - 2018/1/1. N2 - The most common benign tumour of the major salivary glands is the pleomorphic adenoma. They are seen rarely in the minor salivary glands, usually in hard palate, soft palate and nasopharynx. Pleomorphic adenomas in nasal cavity are unusual and may be misdiagnosed because they have predominant myoepithelial cellularity and fewer myxoid stromata compared with those elsewhere. We present a case of 38-year-old male with a 2-year history of left nasal obstruction and epistaxis since 6 months. Diagnostic nasal endoscopic examination showed a soft lobulated mass in left nasal cavity attached to anterior part of the septum. Radiological examination demonstrated soft tissue mass filling left nasal cavity with an eroded septum. The biopsy from the mass was suggestive of pleomorphic adenoma and was resected endoscopically. ...
Pleomorphic adenoma is the most common salivary gland tumor on the head and neck region [1]. Metastasizing pleomorphic adenoma is a rarely detected form of clinic antity [2,3]. According to the World…
MRI and PET images demonstrate a right parotid pleomorphic adenoma. Pleomorphic adenomas are the most common salivary gland tumours. This case was donated to Radiopaedia.org by Radswiki.net
Fifty-two cases of pleomorphic adenoma of minor salivary gland origin and seventy-two cases of pleomorphic adenoma of major salivary gland origin were examined for the presence of hyaline cells (plasmacytoid cells). Hyaline cells were found in 38 percent of the minor salivary gland cases and 21 perc …
Salivary gland tumors most commonly occur in the parotid gland, accounting nearly 85% of all salivary gland tumors. But, 25% of parotid tumors are malignant (cancerous).. Pleomorphic adenoma is the most common type of benign salivary gland tumor. It is typically a slow growing tumor and occur most often in the parotid gland. It is also known as mixed tumor which describes its pleomorphic appearance as opposed to its dual origin from epithelial and myoepithelial elements.. The tumor is usually solitary and presents as a slow growing, painless and firm singular nodal mass. It is usually mobile unless found in the palate and can cause atrophy of the mandibular ramus when located in the parotid gland.. ...
This study was undertaken to evaluate and concentrate on the recurrent pleomorphic adenomas (PAs) of the parapharyngeal space. The records of 9 patients treated for recurrent PAs occupying parapharyngeal space were retrospectively reviewed. The study population comprised 6 women and 3 men with a mean age of 51 (range, 35-79 years). Before the first revision surgery, imaging studies and clinical examinations showed 1 solitary mass in 4 patients, 2 solitary masses in 3 patients, and 3 or more masses in 2 patients. After first revision surgery, 4 patients had rerecurrences with multinodular disease. Two of 4 patients underwent radiation therapy (RT), and the other 2 patients underwent second revision surgery, among whom 1 patient underwent third revision surgery, and the other one was also submitted to RT. Overall, 12 reoperations were performed, and at the end of all operations, 4 patients had rerecurrences and residual disease. In conclusion, we recommend RT to patients with multinodular disease, ...
Bruno Galletti, Francesco Freni, Francesco Gazia, Viviana Nicastro, Pietro Abita, Federico Sireci , Francesco Galletti. Parapharyngeal space lesions account for only 0.5% of head and neck tumours. A 63-year-old male presented primary pleomorphic adenomas arising de novo from minor salivary glands in the parapharyngeal space. We describe the clinical features, pathology, radiological findings and treatment of this lesion. The goal when presented with such a tumour is a correct diagnosis and the in toto excision of the tumor to avoid any recurrence.. Sireci_02.pdf. ...
Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation of parenchymatous glandular cells along with myoepithelial components, having a malignant potentiality. It is the most common type of salivary gland tumor and the most common tumor of the parotid gland. It derives its name from the architectural Pleomorphism (variable appearance) seen by light microscopy. It is also known as Mixed tumor, salivary gland type, which describes its pleomorphic appearance as opposed to its dual origin from epithelial and myoepithelial elements. The tumor is usually solitary and presents as a slow growing, painless, firm single nodular mass. Isolated nodules are generally outgrowths of the main nodule rather than a multinodular presentation. It is usually mobile unless found in the palate and can cause atrophy of the mandibular ramus when located in the parotid gland. When found in the parotid tail, it may present as an eversion of the ear lobe. Though it is ...
Synchronous pleomorphic adenomas of the major salivary glands: a case report.: The presentation of multiple distinct tumors in major salivary glands is rare. Al
Purpose: We sought to identify genomic alterations (GAs) in salivary gland adenocarcinomas, not otherwise specified (NOS), salivary duct carcinomas (SDC), carcinoma ex pleomorphic adenoma (ca ex PA), and salivary carcinoma, NOS. Experimental design: DNA was extracted from 149 tumors. Comprehensive genomic profiling (CGP) was performed on hybridization-captured adaptor ligation-based libraries of 182 or 315 cancer-related genes plus introns from 14 or 28 genes frequently rearranged for cancer and evaluated for all classes of GAs. Results: 590 GAs were found in 157 unique genes (mean 3.9/tumor). GAs in the PI3K/AKT/mTOR pathway were more common in SDC (53.6%) than other histologies (p=0.019) Cyclin dependent kinase GAs varied amongst all histotypes: adenocarcinoma, NOS (34.6%); SDC (12.2%); ca ex PA (16.7%); carcinoma, NOS (31.2%) (p=0.043). RAS GAs were observed: adenocarcinoma, NOS (17.3%); SDC (26.8%); ca ex PA (4.2%); and carcinoma, NOS (9.4%) (p=0.054). ERBB2 GAs, including amplifications and ...
Salama AR, Sakellariou T, The Cervicofacial Advancement Flap, Oral and Maxillofacial Surgery Clinics of North America, 2014. Nadershah M, Alshadwi A, Salama A An unusual case of carcinoma ex pleomorphic adenoma of the parotid metastasizing to the mandible: case report and review of the literature. J Oral Maxillofac Surg. 2013 Feb;71(2):437-42.. McClure SA, Movahed R, Salama A, Ord RA Maxillofacial metastases: a retrospective review of one institutions 15-year experience. Oral Maxillofac Surg. 2013 Jan;71(1):178-88.. Sönmez TT, Prescher A, Salama A, Kanatas A, Zor F, Mitchell D, Zaker Shahrak A, Karaaltin MV, Knobe M, Külahci Y, Altuntas SH, Ghassemi A, Hölzle F.Comparative clinicoanatomical study of ilium and fibula as two commonly used bony donor sites for maxillofacial reconstruction.Br J Oral Maxillofac Surg. 2013 Aug 27.. Zhang T, Lubek JE, Salama A, Dyalram D, Liu X, Ord RA. Treatment of cT1N0M0 Tongue Cancer: Outcome and Prognostic Parameters. J Oral Maxillofac Surg. 2013 Sep 14. ...
METHODS: This cross-sectional study comparatively evaluated 21 cases of pleomorphic adenomas and 21 sections of regular oral mucosa from the files of an oral pathology department. The tissue sections were subjected to immunohistochemical study with a monoclonal antibody specific to CD31 protein to assess vascular density and were also stained with Sirius red to evaluate the levels of collagen. The numbers of positively-stained cells were enumerated in specific fields through morphometric study, with subsequent statistical analysis ...
title: Sinonasal pleomorphic adenoma: A single institution case series combined with a comprehensive review of literatures, doi: 10.1016/j.anl.2018.08.003, category: Article
The proto-oncogene, pleomorphic adenoma gene-like 2 (PLAGL2), is implicated in a variety of cancers including acute myeloid leukemia (AML), malignant glioma, colon cancer, and lung adenocarcinoma. There is additional evidence that PLAGL2 can function
TY - JOUR. T1 - Pleomorphic adenoma with extensive adipose content. AU - Jin, Y. T.. AU - Lian, J. D.. AU - Yan, J. J.. AU - Hwang, T. Z.. AU - Tsai, S. T.. PY - 1996/1/1. Y1 - 1996/1/1. UR - http://www.scopus.com/inward/record.url?scp=0030058826&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0030058826&partnerID=8YFLogxK. U2 - 10.1046/j.1365-2559.1996.t01-2-258289.x. DO - 10.1046/j.1365-2559.1996.t01-2-258289.x. M3 - Article. C2 - 8838128. AN - SCOPUS:0030058826. VL - 28. SP - 87. EP - 89. JO - Histopathology. JF - Histopathology. SN - 0309-0167. IS - 1. ER - ...
Question - Hi, I have an pleomorphic adenoma which has stayed the same - 6F. Find the answer to this and other Medical questions on JustAnswer
Sudhir Kumar Vujhini1, Kandukuri Mahesh Kumar2, Konduru Omkareshwar3, Sridhar Reddy4, Ganesh5. 1Associate Professor, 2Assistant Professor, 3Associate Professor, Department of Pathology, Malla Reddy Institute of Medical Sciences, Hyderabad. 4MDS PG, MNR Dental College, Sanga Reddy, Medak. 5Assistant Professor, Malla Reddy Institue Of Dental Sciences, Suraram, Hyderabad.. Abstract: Pleomorphic adenoma also called benign mixed tumor, is the most common salivary gland tumor. Most of these tumors occur in major salivary glands; Parotid gland happens to be the commonly involved one (about 90 %) and about 10 % of these occur in the minor salivary glands. The most common sites for pleomorphic adenoma of minor salivary glands are the palate, followed by the lips, the cheeks, floor of the mouth, tongue, tonsil, pharynx, the retromolar area and the nasal cavity. FNAC of intraoral swellings is rarely advised. Here, we are reporting a rare case of pleomorphic adenoma arising from the palate diagnosed on FNA ...
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Non-contrast studies -- Sagittal SE T1-weighted MR image reveals a well-circumscribed hypointense mass lesion compared with surrounding parotid tissue, within the superficial lobe.
Non-contrast studies -- Coronal fat-suppressed FSE T2-weighted MR image reveals a well-circumscribed hyperintense mass lesion compared with surrounding parotid tissue, within the superficial lobe, ...
SS noted some prominence of her right eye with mild discomfort over several months. Examination found 2 mm of proptosis on the right side and mild inferior displacement of the globe. A-scan...
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The surgical risks involved in the removal of the tumor vary with the tumor itself. A smaller, more confined tumor will be easier to remove and therefore be less likely to cause damage to the facial nerve located nearby. A tumor that extends to a wider area may carry heavier risk. According to Georgetown University Hospital, surgeons are extremely careful in working near the facial nerve and most patients heal normally and do not experience any abnormal function. ...
An Unusual Variant of a Common Palatal Salivary Gland Tumor: Case Report of a Pleomorphic Adenoma with Significant Lipomatous Metaplasia ...
Patients, Carcinoma, Saliva, Syndrome, Tissue, Adenoma, Pleomorphic Adenoma, Association, Cancer, Carcinomas, Cell, Head, Human, Lymph, Lymph Node, Metastases, Neck, Risk, Squamous Cell Carcinoma, Tongue
A 68-year-old man was referred to our oculoplastics clinic by his primary ophthalmologist with a three month history of an expanding mass in his left superotemporal orbit. He had been followed yearly with CT scans since a recurrent left lacrimal gland lesion was removed 26 years ago. The initial lesion was resected 13 years prior to that, when the patient was 29 years old. The pathology reports from both surgeries described a pleomorphic adenoma of the lacrimal gland with no malignant criteria. Neither report indicated whether the tumor had been completely resected. The last CT scan was performed almost a year before symptoms started and was read as stable with no tumor recurrence. His only current complaint was of slight episodic pain in the affected area. He denied any diplopia, vision loss, headache or other systemic symptoms. He was also treated for hypertension, hypothyroidism and dyslipidemia ...
TY - JOUR. T1 - Intrasellar salivary gland-like pleomorphic adenoma. T2 - Case report. AU - Takahashi, Satoshi. AU - Mikami, Shuji. AU - Akiyama, Takekazu. AU - Kawase, Takeshi. PY - 2011/2/1. Y1 - 2011/2/1. N2 - BACKGROUND AND IMPORTANCE: We present a rare case of a patient with intrasellar salivary gland-like pleomorphic adenoma and review the 2 previously reported cases of the clinical entity to identify their common clinical features. CLINICAL PRESENTATION: A 56-year-old Asian man visited our hospital with a chief complaint of visual disturbance caused by brain tumor that filled up the sella turcica with suprasellar extension. The patient underwent craniotomy via a left pterional approach, and the subdural, intracranial portion of the tumor was totally removed, with every artery and nerve preserved. Pathological diagnosis of the tumor was intrasellar salivary gland-like pleomorphic adenoma. Three years after the operation, the patient remains free from tumor recurrence. CONCLUSION: Tumors in ...
Discussion: Myoepithelial carcinomas (or malignant myoepitheliomas) are rare malignant salivary gland neoplasms in which the tumor cells show myoepithelial differentiation. The entity was first described by Stromeyer et al. in 1975. The tumor was included in the WHO classification of salivary gland neoplasms as a distinct clinicopathologic entity in 1991. About 60% to 70% of myoepithelial carcinomas develop in a benign mixed tumor (carcinoma ex pleomorphic adenoma), and the remainder arise de novo. Histologically, malignant myoepitheliomas are composed of one or several cell types: spindle, plasmacytoid, epithelioid, and clear cells. Frequently, one of the cell types predominates. The neoplastic cells grow either as multiple nodules or as large solid sheets separated by variable amounts of intervening hyaline or myxoid stroma. By far, the multinodular growth pattern is more prevalent. The cytologic features generally reflect the histology. The cytologic smear can show spindle, epithelioid or ...
OBJECTIVE: The aim of this study was to report the clinicopathological features of 18 epithelial tumors of the lacrimal gland treated in a single institution. STUDY DESIGN AND SETTING: Clinical data and treatment were recorded and histological features reviewed. RESULTS: Twelve tumors (66.7%) were adenoid cystic carcinoma (ACC), 5 (27.8%) pleomorphic adenoma (PA), and 1 (5.5%) carcinoma ex pleomorphic adenoma. All patients with ACC presented with advanced clinical stage, and most were treated by wide surgical resection followed by adjuvant radiotherapy. No recurrence was observed in 4 cases of ACC; however, 7 patients died from persistence of disease or by local and/or distant recurrence. All PA patients were successfully treated by surgical resection. CONCLUSIONS: Epithelial lacrimal gland tumors are mainly PA and ACC, and malignancies are more common than benign tumors. Although ACC presented typically with advanced clinical stage, 33% of the patients survived without tumor recurrence or ...
TY - JOUR. T1 - Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma from pleomorphic adenoma?. AU - Chandan, Vishal S.. AU - Wilbur, David. AU - Faquin, William C.. AU - Khurana, Kamal K.. PY - 2004/8/25. Y1 - 2004/8/25. N2 - The authors examined the role of c-kit antigen expression in cell block material obtained by fine-needle aspiration in differentiating between adenoid cystic carcinoma and pleomorphic adenoma. It was found that c-kit expression was not restricted to adenoid cystic carcinomas; instead, c-kit was expressed in pleomorphic adenomas as well. Thus, c-kit was not useful in distinguishing between these two types of lesions.. AB - The authors examined the role of c-kit antigen expression in cell block material obtained by fine-needle aspiration in differentiating between adenoid cystic carcinoma and pleomorphic adenoma. It was found that c-kit expression was not restricted to adenoid cystic carcinomas; instead, ...
Chordomas are rare tumors that are usually located in the sacrococcygeal and sphenooccipital region. Their cytologic diagnosis is rather straightforward when sampled by fine-needle aspiration (FNA) from these characteristic locations, especially when physalipherous cells are present. However, chordomas may pose difficult diagnostic challenges when encountered in unusual locations, such as the parapharyngeal region. We report the cytologic findings of a recurrent chordoma sampled through transoral FNA from the parapharyngeal space of a 66-year-old woman. As the prior history of chordoma was not available during the rapid onsite evaluation, the presence of bland epithelioid nonvacuolated cells and spindle cells intimately admixed with a fibrillary, intensely metachromatic material led to an initial diagnosis of pleomorphic adenoma. Review of the patients prior pathology specimen and of the Papanicolaou-stained smears and cellblock sections showing rare multivacuolated (physalipherous) cells led ...
Abstract Introduction: Polymorphous low grade adenocarcinoma (PLGA) is a rare salivary gland neoplasm with an indolent course. It occurs primarily in the minor salivary glands but can rarely occur in the major salivary glands. It usually occurs in the fifth to seventh decades of life with female preponderance. Case Report: A 16-year-old male presented with recurrent painless swelling in the right preauricular region and with a history of surgical intervention at the same site in the past. His histopathology report was suggestive of pleomorphic adenoma. The swelling recurred after one year of excision and a superficial parotidectomy was performed. The detailed histopathological examination was suggestive of Polymorphous low grade adenocarcinoma. In view of close margins, the patient was given adjuvant radiotherapy. Thirty-three months post-surgery, he is alive and disease-free. We describe a rare case of PLGA of the parotid gland in a teenager with its clinical characteristics, histopathological
E-cadherin is a calcium dependent cell adhesion molecule, important in cell to cell interactions in epithelial tissues. The present study examined E-cadherin expression in normal salivary glands, pleomorphic adenoma, Warthins tumor, mucoepidermoid carcinoma, acinic cell carcinoma, adenoid cystic carcinoma and adenocarcinoma of salivary glands in paraffin sections using a monoclonal antibody (5H9). This study is firstly reported E-cadherin expression in the salivary gland and tumors.,BR,In normal submandibular and parotid gland, E-cadherin staining was confined to the cell membrane of acinar and ductal cells. In excretory ducts, high columnar cells showed the strongest reaction at the basal aspect and ductal basal cells were weakly positive or negative, the basement membrane zone lacked staining. No E-cadherin reaction was observed in modified myoepithelial cells and plasmacytoid cells. In pleomorphic adenoma and mucoepidermoid carcinoma, E-cadherin was positive at the lateral cell membrane or ...
Canalicular adenoma is a type of benign salivary gland tumor that occurs most often in minor salivary glands. In addition to pleomorphic adenoma, the two are the most common tumors of the upper lip. In 95% of cases, canalicular adenoma occurs on the upper lip. The next most common location is the buccal mucosa (inner cheek). Other sites of the mouth, including the parotid gland, are rare for this disease. Canalicular adenoma is most likely to occur in older adults around 70 years of age. There is a predilection for gender with most cases being in females. Canalicular adenoma is characterized as a slow growing, painless swelling, whose diameter can be up to 2 cm. It can be normal or bluish in color. The appearance of this tumor microscopically is very distinct. There are cords of columnar or cuboidal epithelium, which have basophillic nuclei. Parallel rows of cords appear to form long canals. Frequently, there are large cystic spaces. There are no stromal alterations evident. Treatment usually ...
Classically these tumors show biphasic manifestation with admixture of varying amounts of polygonal salivary gland cells and spindle shaped myoepithelial cells. The underlying stroma could be mucoid / myxoid / cartilagenous / hyaline. Even though these tumors are not encapsulated but thickening of parotid fascia around the mass gives it an encapsulated appearance (pseudocapsule).. The main cause for this tumor is juxtapositioning of PLAG gene to the gene for beta catenin. This causes activation of catenin pathway leading on to inappropriate cell division.. ...
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Pleomorphic adenoma, also known as benign mixed tumor, is the most common tumor of salivary gland origin, accounting for about 60-70% of all salivary gland tumors (Peel and Seethala, 2007; Downer, et al., 2011; Papadogeorgakis ...
On one of the first three fridays in october, the president of the college cancels classes and declares it mountain day. Surgical treatment of pleomorphic adenoma of the parotid gland: report of cases
This post is part of a wider series about all the 6 CX disciplines that represent the CXPA Framework around which the CCXP exam is structured and that we cover in the CX Masterclass. Follow Nienke Bloem and Rosaria Cirillo to be notified as soon as a new blog post is published.. Find here the complete list of the other posts in this series:. 1. CX Strategy. 2. Customer Understanding. 3. Design, Improvement and Innovation. 4. Measurement. 5. Governance. 6. Culture (will be published on the 4th of December). Extra: CXPA exam & Becoming CCXP (will be published on the 11th of December). About this series. This post was originally posted on Wow Now and is part of the CX Framework series by Rosaria Cirillo and Nienke Bloem.. The foundations for these blogposts are written by Milou van Kerkhof following the June 2017 CX Masterclass given by Nienke Bloem and Rosaria Cirillo. Milou attended this as a newcomer in Customer Experience. These blogposts have been slightly edited and reflect only the ...
The Certified Customer Experience Professional (CCXP) credential requires ongoing professional development to maintain an active certification status. As such, certificants are required to complete 20 hours of CCXP Renewal Credits (CRCs) in order to renew their certification every two years. The renewal date of the new certificate will be two years from the expiration date of the last certificate issued.. One CRC is earned for each hour (60 minutes) spent in a planned, structured professional development activity. CRCs will be accepted for the certification renewal requirement as long they are directly related to the CCXP Exam Blueprint and meet the guidelines listed below. CCXPs must earn a total of 20 CRCs in a minimum of two of the professional development activity categories (Program attendance, Speaking, College or University Courses, CXPA Contributions) for renewal. CRCs accumulate for a two-year period starting immediately after the certification is issued and cannot be carried over to ...
Learn about the causes, symptoms, diagnosis & treatment of Tumors of the Head and Neck from the Professional Version of the Merck Manuals.
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Medical information, Adenoma - secreting. Definition of Adenoma - secreting, symptoms of Adenoma - secreting, treatment of Adenoma - secreting, and prevention of Adenoma - secreting. Exams and Tests Adenoma - secreting.
Looking for information on Adenoma? Medigest has all you need to know about Adenoma - Symptoms and Signs, Causes, Treatments and definition
ဆေးပညာအချက်အလက်များကို Hello Sayarwon တွင်ရှာဖွေနိုင်ပြီး၊ Bronchial adenoma (လေပြွန်အကျိတ်ဖြစ်ခြင်း) , ၏ အဓိပ္ပါယ်ဖွင့်ဆိုချက်၊ ဖြစ်ပွားမှု အကြောင်းရင်းများနှင့် လက္ခဏာများ၊ အဖြေရှာကုသပုံများကိုလည်း ရှာဖွေနိုင်ပါသည်။
Introduction: Treatment of choice for pleomorphic adenoma of the hard palate is wide local resection of the tumor including the overlying mucosa and underlying periosteum. Most conventional methods for covering the resulting palatal wound are prosthetic devices. In this case, we examined the validity of grafting a polyglycolic acid sheet and fibrin glue over a mucosal defect of the palate with a bony surface, as a substitute for a surgical splint. Case Report: A 39-year-old male presented with a large, solid mass located on the right hard palate. Fine-needle aspiration cytology suggested pleomorphic adenoma. The patient underwent wide local resection of the lesion, and the mucosal defect was immediately covered with polyglycolic acid sheets, that were fixed with a fibrin glue spray. These sheets were tightly placed and remained in the wound, which led to complete epithelialization of the wound surface. Conclusion: Grafting the polyglycolic acid sheet with fibrin glue fixation is a useful substitute for
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether radiation therapy is more effective when given together with chemotherapy or alone after surgery in treating salivary gland tumors.. PURPOSE: This randomized phase II/III trial is studying radiation therapy with or without chemotherapy to see how well it works in treating patients with high-risk malignant salivary gland tumors that have been removed by surgery. ...
Malignant salivary gland tumours are staged using the TNM staging system: T: Tumour Tx: primary tumour cannot be assessed T0: no evidence of primary tumour T1 less than or equal to 2 cm in maximal diameter no extra-parenchymal extension T2...
Salivary Heparanase Level Is a Potential Biomarker to Diagnose and Prognose the Malignant Salivary Gland Tumor. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
The success rate of these procedures is very much dependent on the ability of the operator and the equipment used. The equipment has to have the capabilities to operate at very low power because the syringoma are not very thick and a powerful ablation could result in damage to the dermis and therefore permanent scarring.. The method used to remove the syringoma by Electrodesiccation is very simple and this involves simply ablating the lesions from the top and level it off with the rest of the surrounding skin. However since the syringoma reside inside the dermis as well, in order to minimise recurrence it is advisable to ablate them deeper inside the dermis. This is because it has been reported that most of the recurrence of syringoma is due to the fact that simply leveling off the syringoma with the surrounding skin is not sufficient to remove them completely and they will regrow soon after healing. A couple of weeks after the cosmetic procedure.. ...
Summary: A 38-year-old woman presented with a mass on her left hand that had been gradually increasing in size over a 3-year period. Hand radiography was ob...
OUTLINE: This is a multicenter study.. Patients receive gemcitabine IV over 30 minutes on days 1 and 8. Patients also receive either cisplatin IV over 1 hour on day 2 OR carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.. Patients are followed at 4 weeks, every 3 months for 1 year, and then every 6 months thereafter until relapse.. PROJECTED ACCRUAL: A total of 11- 34 patients will be accrued for this study within 1.5-3 years. ...
Ram Babu1, Sudhir Kumar Vujhini2, Prathima3, Ram Manohar Lohia4, Kandukuri Mahesh Kumar5. 1Assistant Professor of Pathology, E.S.I Model Hospital, Nacharam, Hyderabad, Andhra Pradesh.. 2Associate Professor of Pathology, MRIMS, Suraram, Hyderabad, Andhra Pradesh.. 3Assistant Professor of Pathology, Osmania Medical College, Hyderabad, Andhra Pradesh. 4Department of Radiology, E.S.I Model Hospital, Nacharam, Hyderabad, Andhra Pradesh 5Assistant Professor, Department of Pathology, MRIMS, Suraram, Hyderabad. Abstract:. Lymphadenopathy can masquerade as other pathological entities due to their proximity to many sites, thus clinical misjudgment can happen. Ours is such example where Granulomatous cervical lymphadenopathy is clinically thought of as Pleomorphic adenoma of Parotid gland. They need careful review, radiological correlation before committing for final impression.. Key words: Parotid, Pleomorphic adenoma, Lymphadenopathy, Granulomatous Cervical lymphadenitis, Fine needle aspiration ...
Examples adenoid cystic carcinoma cribriform adenocarcinoma of minor salivary glands polymorphous adenocarcinoma pleomorphic adenoma (...)
TY - JOUR. T1 - Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands. AU - Yamamoto, Yuzo. AU - Virmani, Arvind K.. AU - Wistuba, Ignacio I.. AU - McIntire, Donald. AU - Vuitch, Frank. AU - Albores-Saavedra, Jorge. AU - Gazdar, Adi F.. PY - 1996/1/1. Y1 - 1996/1/1. N2 - Adenoid cystic carcinomas (ACC) constitute approximately 20% of malignant salivary gland tumors. Several histological types of ACC are recognized and may coexist in a single tumor. The authors divided ACC into lower grade (tubular and cribriform subtypes) and higher grade (trabecular and solid) subtypes. A preliminary analysis of 10 ACCs showed a relatively high incidence of loss of heterozygosity (LOH) at the p53 and RB genes and low or absent K-ras mutations and LOH at chromosomal loci 3p, 5q, 8p, and 9p. From 21 tumors, the authors carefully microdissected and analyzed 36 subtype foci. Three interrelated pieces of evidence indicate that the relatively poor ...
A 32 year old woman presented with a large swelling in the left parotid area. Past history revealed that the patient had undergone enucleation of a left parotid mass at 9 years of age that showed calcular atrophy with sialadenitis, and superficial parotidectomy of a recurrent mass at 15 years of age that was considered pleomorphic adenoma. A magnetic resonance imaging showed an 11.8 x 6 cm mass in the left parotid area extending into the infratemporal fossa and the parapharyngeal space. The mass was removed by total parotidectomy. ...
Introduction Minor salivary gland neoplasms of epithelial origin are rare in children and adolescents and most are not well documented, except for a few small series and case reports. This study...
Dermatol Sinica 4: 1-6, 1986. Seven cases of chondroid syringoma of the skin collected from 1983 to 1985 are reported. The patients ranged from 26 to 58 years of age and 4 of them were male. They presented as asymptomatic solitary dermal or subcutaneous nodule. The sites of predilection were the nose (4 cases) and the chin (2 cases); one unusual case occurred on the foot. The tumors were well circumscribed and composed of epithelial cells forming solid nests or glandular structures in a chondroid or myxoid stroma. Squamous metaplasia was occasionally observed. Except one case with 3 recurrences, the others did not recur. A complete surgical excision is usually adequate. ...
Salivary Gland Tumor Removal clinics in Romania at the best price. Find doctors, specialized in Ear, Nose and Throat (ENT) and compare prices, costs and reviews.
Syringoma: A benign tumor of the sweat glands which is usually multiple and results from malformation of sweat ducts. It is uncommon and more common in females than in males. It is most likely to appear at adolescence, and further lesions may develop during adult life. It does not appear to be hereditary. (Rook et al., Textbook of Dermatology, 4th ed, pp2407-8)
Syringoma on the penis can be quite distressing and worrisome for most individuals. People often fear the lesion for being sexually transmitted such as condyloma accuminata.
We present a case of cutaneous leiomyomas (CL) arising in a pleomorphic adenoma (PA) of the parotid gland. PA and CL are benign tumors arising from the parotid gland and the erector pilli muscle, respectively. They both have a benign clinical course and in most cases leiomyomas are multiple in nature. PAs of the parotid are the most frequent benign tumors of the major salivary glands. To our knowledge this is the first case of PA with CL.
We show that TRH mRNA is expressed in human fetal and adult pancreata, and that TRHR mRNA is expressed in fetal human pancreas but not in adult human pancreas. Comparative evaluation between two immunoenzymatic techniques (FAST and cialis reviews by men Phadezym) and the Phadebas RAST in food allergy. Implications for community interventions and directions for future research are discussed.. PBX1 expression correlated with histologic neuroblastoma cialis pills subtypes, with highest expression in benign ganglioneuromas and lowest in high-risk neuroblastomas. Insulin temperature and stability under simulated transit conditions.. We attempted a meta-analysis of telemedicine research studies of the costs associated with telemedicine. The purpose of this study is to evaluate the usefulness of dual-time-point 18F-FDG cialis patent expiration date extended PET/CT for discriminating between benign and malignant salivary gland tumors. The study included 18 eyes of 16 patients who underwent cataract ...
|b||i|Background: |/i||/b|Salivary gland tumors (SGTs) are known for their specific heterogeneity and ambiguous outcome for the affected patients. The |i|LKB1 |/i|a
In a sense, though I tend to do all right with them, I truly hate the whole multiple choice approach to medicine. My diagnostic capability is not based on whether I can recognize a tyrosine crystal in a single poorly 2D image from a pleomorphic adenoma slide. What is my triage method? What tests do I run on a scant specimen? If I have a malignancy of unknown origin in an elderly womans pleural fluid, I dont need to have the second leading cause of malignant pleural effusions memorized and then try to figure out whether the questions as written ten years ago or ten months ago and whether a few things switched places on the charts. I need a basic, streamlined workup that is most likely to lead me to the correct diagnosis for the least money and waste of specimen. I need to know when to ask for help, when to ask for flow cytometry, and when to get a cell block and what stains to order on the cell block, and when to stop throwing money and time down the drain and call the clinician to ask for ...
In a sense, though I tend to do all right with them, I truly hate the whole multiple choice approach to medicine. My diagnostic capability is not based on whether I can recognize a tyrosine crystal in a single poorly 2D image from a pleomorphic adenoma slide. What is my triage method? What tests do I run on a scant specimen? If I have a malignancy of unknown origin in an elderly womans pleural fluid, I dont need to have the second leading cause of malignant pleural effusions memorized and then try to figure out whether the questions as written ten years ago or ten months ago and whether a few things switched places on the charts. I need a basic, streamlined workup that is most likely to lead me to the correct diagnosis for the least money and waste of specimen. I need to know when to ask for help, when to ask for flow cytometry, and when to get a cell block and what stains to order on the cell block, and when to stop throwing money and time down the drain and call the clinician to ask for ...
This lesion is described as a soft tissue enlargement. Reactive soft tissue enlargements can be excluded from differential diagnosis because the lesion has been present for several years and is progressively enlarging. Also, the lesion is not painful, except for occasional soreness associated with the denture.. Within the category of tumors, malignant tumors can be excluded because the lesion is very slowly growing and essentially asymptomatic. Soft tissue cysts are eliminated because they are fluid filled and have “hydraulic†properties, meaning that they are compressible and expand in all directions uniformly. Cysts do not have a surface with a depression or fissure.. From the category of benign tumors, epithelial lesions and salivary gland tumors can be excluded. Epithelial lesions can be excluded because these have a white, rough surface. Salivary gland tumors can be excluded because the lesion appears to be arising from the alveolar ridge mucosa. Salivary gland tumors may arise ...
Most salivary gland tumors are benign and occur in parotid gland. The most common sign of a salivary gland tumor is a painless mass.
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If you are suffering from itchy vulva that is unresponsive to several oral and topical medication, you may have vulvar syringomas.
RODERIC (Repositori dObjectes Digitals per a lEnsenyament la Recerca i la Cultura) es el repositorio institucional de la Universitat de València. Se concibe como una ventanilla única para el acceso y la difusión de la producción digital de la Universitat. RODERIC responde al compromiso de la Universitat con el movimiento de acceso abierto al conocimiento adquirido con su adhesión a la Declaración de Berlín (30 Septiembre de 2008).
Oral tumors - skin tumors - salivary gland tumors - craniofacial tumors: in communion with the teachings of oral pathology, ENT, ophthalmology; study of precancerous lesions, etiology and pathogenesis of tumors, their biology and clinical behavior, diagnostic and classification framework, therapy principles with particular reference to the two aspects of surgery: demolition and reconstruction. Basic principles of oncological and radiant treatment ...
Adenoid cystic carcinoma (ACC) is a relatively rare form of cancer that most commonly develops in the salivary glands or other regions of the head and neck.
Če se ne sprejmejo terapevtski ukrepi, se pri bolnikih z adenomi prostate lahko razvije kronična ledvična odpoved. Pri adenoma prostate se včasih razvije akutno zadrževanje urinov. Pacient ne more urinirati, ko je mehur je poln, kljub intenzivni želji. Za odpravo zadrževanja sečnice se pri moških kateterizira mehur, včasih pa je nujna operacija ali prebadanje mehurja.. Še en zaplet pri adenoma prostate je hematurija. Pri številnih bolnikih je opaziti mikroekemurozo, vendar se pojavijo tudi pogoste intenzivne krvavitve iz tkiva adenoma (v primeru poškodb zaradi manipulacije) ali krčne žile na območju vratu mehurja. S tvorjenjem strdkov je mogoče razviti tamponado mehurja, v katerem je nujna kirurgija potrebna. Pogosto vzrok krvavitve v adenoma prostate postane diagnostična ali terapevtska kateterizacija.. Kamni mehurja pri adenoma prostate lahko nastanejo zaradi stoječega urin ali migrirajo iz ledvic in sečil. Pri cistolitiaziji se klinična slika adenoma prostate dopolnjuje s ...
Zdravljenje adenoma prostate z repom. Kljub očitnemu napredku pri zdravljenju adenoma prostate, tradicionalne medicine, so metode, uporabljene za zdravljenje te bolezni pred stoletjem, še vedno pomembne. Takšno zdravljenje adenoma prostate z ljudskimi zdravili je zelo učinkovito, zato bo rezultat opazen hitro. Sončnična semena. Priporočljivo je, da jedo suho (vendar ne ocvrto) bučno seme. Pred uporabo je treba izdelek očistiti iz trde lupine, zelena folija pa mora ostati. Vzemite to sredstvo priporočljivo za gramov na dan za mesec. ljudsko zdravljenje. Ali se adenoma zdravi brez prizadevanj pacienta in kakšne so možne posledice, na recepciji zdravnik vsakemu posamezniku pojasni posamezno. Sprememba načina. Bolniki z adenoma prostate so večinoma starejši od 50 let. Pogosteje so moški s prekomerno težo, ki se ne želijo omejiti v hrani, preživeti čas na televiziji. Pri ljudskih metodah je bilo zdravljenje s čebelasto poddomenom adenoma prostate pridobljeno z obsežnim obsegom. ...
Pri moškem v 72 letih je prišlo do adenoma prostate. Obrnil se je k zdravniku, ko je bila bolezen že v zanemarjeni obliki, brez katetra pa ni bilo mogoče izprazniti mehurja. Takoj je ponudil operacijo za odstranitev adenoma, se je strinjal, odšel v bolnišnico, a ko sem videl post-kirurške bolnike, prestrašeni, izkazalo, da je z operacijo in je bil zaključen domov s katetrom. Po nasvetu urologu začel zdravljenje adenoma folk pravna sredstva: prvi dan posta mora jesti 0,5 skodelice orehov, v drugem - pol skodelice sončničnih semen, tretji dan od povprečja žarnice. Nadaljevati to zdravljenje prostate za tri mesece.. Moški je to zdravilo uporabljal in adenoma je izginila, a ker je imel nezdrav način življenja, se je nekaj let kasneje ponovno pojavil. Potem se je odločil, da bi adenoma zdravil z magnetom. Kupil je biokorrektorja iz podjetja Nevoton, vendar je bil učinek zdravljenja majhen. Potem je po mnenju zdravnika moški večkrat vzel magnet - od zvočnika radia. Poleg adenomom ...
Treatments & Remedies for Prostate Adenoma Prostate adenoma Adenoma epithelial tumor, usually benign, of similar structure to a gland. Tumor whose main characteristic is to have spaces lined with epithelium.
ADENOMA HIPOFISARIO PDF - En el presente trabajo se analiza el significado de la actividad proliferativa mediante inmunotinción con Ki en una serie de adenomas hipofisarios. Check
This page was last edited 02:09, 24 October 2017 by mahshid mir. Based on work by Jyostna Chouturi, Aarti Narayan and Prashanth Saddala and wikidoc user WikiBot ...
Though it is classified as a benign tumor, pleomorphic adenomas have the capacity to grow to large proportions and may undergo ... An important point of view is that recurrent pleomorphic adenomas may occur after a very long time from primary surgery, on ... Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation of epithelial (ductal ... There have been several approaches for surgery of parotid pleomorphic adenoma in the course of time. Enucleation of the tumor ( ...
Salivary gland Pleomorphic adenoma Di Palma, S. (Jul 2013). "Carcinoma ex pleomorphic adenoma, with particular emphasis on ... the history of a pleomorphic adenoma at that location. Relative incidence of parotid tumors, showing carcinoma ex pleomorphic ... Carcinoma ex pleomorphic adenoma (ca ex PA) is a type of cancer typically found in the parotid gland. It arises from the benign ... Carcinoma ex pleomorphic adenoma is diagnosed by examining it under the microscope with consideration of the individual history ...
Pleomorphic adenoma • Pleurodont • Plica fimbriata • Polk E. Akers • Polymorphous low-grade adenocarcinoma • Polynoxylin • ... Canalicular adenoma • Canine tooth • Cantilever mechanics • Carbon dioxide laser • Caries vaccine • Carnassial • Case School of ...
Summary: Associated Cancers: colorectal and ovarian cancer; pilomatrixoma; medulloblastoma; pleomorphic adenomas; malignant ... pleomorphic adenomas, and malignant mesothelioma. While less is known about the exact mechanism of α-catenin, its presence in ... "The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the β-catenin signaling pathway". ...
It is important that other tumors such as pleomorphic adenoma, basal cell adenoma, adenoid cystic carcinoma, and teratoma be ... "congenital pleomorphic adenoma"). A clinicopathologic, immunohistochemical and ultrastructural study of nine cases". Am J Surg ... It has previously been referred to as congenital basal cell adenoma, embryoma, or basaloid adenocarcinoma. It is an extremely ... Seifert, G.; Donath, K. (1997). "The congenital basal cell adenoma of salivary glands. Contribution to the differential ...
... Ceruminous pleomorphic adenoma Ceruminous syringocystadenoma papilliferum All of the tumors are ... Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V (March-April 2008). "Primary pleomorphic adenoma of the ... Other tumors which need to be excluded include a neuroendocrine adenoma of the middle ear (middle ear adenoma), paraganglioma, ... Ceruminous adenoma are rare tumors, accounting for less than 1% of all external ear tumors. The patients will present with a ...
Contrary to pleomorphic adenoma, it is non recurrent. Pleomorphic adenoma Image by Mikael Häggström, MD. References for entries ... Warthin's tumor is the second most common benign parotid tumor after pleomorphic adenoma, but its prevalence is steadily ...
PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, salivary gland pleomorphic; 181030; PLAG1 Adenomatous polyposis ... TCF4 Pituitary adenoma, ACTH-secreting; 219090; AIP Pituitary adenoma, growth hormone-secreting; 102200; AIP Pituitary adenoma ... EIF2B4 Leydig cell adenoma, somatic, with precocious puberty; 176410; LHCGR Leydig cell hypoplasia with hypergonadotropic ... SCN4A Parathyroid adenoma with cystic changes; 145001; HRPT2 Parathyroid carcinoma; 608266; HRPT2 Parietal foramina 1; 168500; ...
"Tenascin and fibronectin expression in carcinoma ex pleomorphic adenoma". Applied Immunohistochemistry & Molecular Morphology. ...
The histologic differential diagnosis includes adenoid cystic carcinoma and pleomorphic adenoma. Intermed. mag. High mag. They ...
8, 17 and vimentin in pleomorphic adenoma of the salivary glands]". Arkh. Patol. 51 (10): 28-35. PMID 2482017. Eichbaum QG, ...
... showing carcinoma ex pleomorphic adenoma at right. Relative incidence of submandibular tumors, showing carcinoma ex pleomorphic ... adenoma at bottom-right. Acinic cell carcinoma of the lung is a very rare variant of lung cancer that, in this organ, is ...
They are morphologically identical to pleomorphic adenoma and have a female predilection. They range from developing deep ... The histopathology findings revealed: "small groups as well as scattered pleomorphic epithelial cells having hyperchromatic ... "the tumour had an expansive growing pattern and a few pleomorphic, atypical cells, and a rare mitotic activity."(Tural ...
... such as pleomorphic adenoma, a significant outcome is also the rate of tumor recurrence. Pleomorphic adenomas may recur after a ... The most common form of benign parotid neoplasms are pleomorphic adenomas and Warthin's tumor. The most common form of ... Silvoniemi, Antti; Pulkkinen, Jaakko; Grénman, Reidar (November 2010). "Parotidectomy in the treatment of pleomorphic adenoma ... "Parotid pleomorphic adenomas: Factors influencing surgical techniques, morbidity, and long-term outcome relative to the new ...
About 40-60% of SDC arise in pleomorphic adenomas. Most, if not all, SDCs express androgen receptor by immunohistochemistry. ... October 2016). "Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 ...
The benign tumors include ceruminous adenoma, ceruminous pleomorphic adenoma, and ceruminous syringocystadenoma papilliferum. ...
1998). "Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas". Oncogene. 16 (7): 865 ...
Microscopically, its histology can be confused with an adenoid cystic carcinoma and a pleomorphic adenoma. Polymorphous low- ...
"PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using ... Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is ... Voz ML, Agten NS, Van de Ven WJ, Kas K (2000). "PLAG1, the main translocation target in pleomorphic adenoma of the salivary ... in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter". Oncogene. 16 (11 ...
February 2002). "Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma ... The same mutations that lead to pituitary adenomas in mice can be found in similar cancers in humans. Its presence is ... Fedele M, Pierantoni GM, Visone R, Fusco A (September 2006). "Critical role of the HMGA2 gene in pituitary adenomas". Cell ... May 2002). "Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas". Oncogene. 21 (20): ...
Other suggestions included ameloblastoma or a benign salivary mixed tumor (also known as a pleomorphic adenoma). In the 1980s, ...
Pleomorphic adenoma is seen to be a common benign neoplasm of the salivary gland and has an overall incidence of 54-68%. The ... The most common of these include pleomorphic adenoma (70% of tumors, of which 60% occur in females) and Warthin tumor (i.e. ... With various benign lesions, most commonly the pleomorphic adenoma, there is a risk of developing malignancy over time. As a ... The most common salivary gland neoplasms in children are hemangiomas, lymphatic malformations, and pleomorphic adenomas. ...
The promoter contains binding sites for Ikaros2, Nuclear Factor Y, and at least three binding sites for Pleomorphic adenoma ...
Tumors arising from other tissues may also produce a cartilage-like matrix, the best-known being pleomorphic adenoma of the ...
Even though it is a benign tumor, it must be separated from a basal cell adenoma, pleomorphic adenoma, adenoid cystic carcinoma ... "Distinctive pattern of glial fibrillary acidic protein immunoreactivity useful in distinguishing fragmented pleomorphic adenoma ... Canalicular adenoma is a benign, epithelial salivary gland neoplasm arranged in interconnecting cords of columnar cells. This ... Suarez P, Hammond HL, Luna MA, Stimson PG (Aug 1998). "Palatal canalicular adenoma: report of 12 cases and review of the ...
... also known as pleomorphic adenomas). Benign tumors are almost always cured by surgery. Very rarely, they may become cancer if ... Hepatic adenomas are a rare benign tumour of the liver, which may present with hepatomegaly or other symptoms. Breast adenomas ... An adenoma is a benign tumor of epithelial tissue with glandular origin, glandular characteristics, or both. Adenomas can grow ... Over time adenomas may transform to become malignant, at which point they are called adenocarcinomas. Most adenomas do not ...
They included pleomorphic adenoma, myoepithelioma, myxoid neurofibroma, neurothekeoma (nerve sheath myxoma), chondroid ...
2007). "Binding of pleomorphic adenoma gene-like 2 to the tumor necrosis factor (TNF)-alpha-responsive region of the NCF2 ... 2005). "Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter". Am. J. ... "Entrez Gene: PLAGL2 pleiomorphic adenoma gene-like 2". Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, ...
... as well as pleomorphic adenoma. Metaplasia Dysplasia Barrett esophagus - a columnar cell metaplasia of squamous epithelium ...
Pleomorphic adenoma gene, General transcription factor IIIA, Stimulating protein 1, CCAAT/enhancer binding protein, GC box ...
Plasmacytoma Plasmacytosis Pleomorphic T-cell lymphoma (non-mycosis fungoides CD30− pleomorphic small/medium-sized cutaneous T- ... Paget's disease of the breast Papillary eccrine adenoma (tubular apocrine adenoma) Papillary hidradenoma (hidradenoma ... Pleomorphic fibroma Pleomorphic lipoma Plexiform fibrohistiocytic tumor Porokeratotic eccrine ostial and dermal duct nevus ... Adenoma sebaceum Adult type of generalized eruption of cutaneous mastocytosis African cutaneous Kaposi sarcoma African ...
Pleomorphic Adenoma Gene (PLAG) C2H2 Zinc Finger Transcription Factors 2 (ZF02) Vertebrate SMAD Family of Transcription Factors ...
... adenoma, liver cell MeSH C04.557.470.035.140 - adenoma, oxyphilic MeSH C04.557.470.035.155 - adenoma, pleomorphic MeSH C04.557. ... adenoma, bile duct MeSH C04.557.470.035.095 - adenoma, chromophobe MeSH C04.557.470.035.100 - adenoma, islet cell MeSH C04.557. ... adenoma MeSH C04.557.470.035.012 - acth-secreting pituitary adenoma MeSH C04.557.470.035.025 - adenoma, acidophil MeSH C04.557. ... adenoma, acidophil MeSH C04.557.465.625.650.075 - adenoma, basophil MeSH C04.557.465.625.650.095 - adenoma, chromophobe MeSH ...
Benign epithelial tumors Pleomorphic adenoma Warthin's tumor Myoepithelioma Basal cell adenoma Oncocytoma Canalicular adenoma ... Carcinoma ex pleomorphic adenoma Mammary analogue secretory carcinoma Carcinosarcoma Metastasizing pleomorphic adenoma Squamous ... Salivary gland tumours, also known as mucous gland adenomas or neoplasms, are tumours that form in the tissues of salivary ... "Mucous Gland Adenoma: The Spectrum of Growth Patterns and the Diagnostic Challenges". Advances in Anatomic Pathology. 27 (6): ...
... and spindle cell oncocytoma 11.4 Pituitary adenoma/PitNET 11.5 Pituitary blastoma 12.1 Metastases to the brain and spinal cord ... astrocytic gliomas 1.4.1 Pilocytic astrocytoma 1.4.2 High-grade astrocytoma with piloid features 1.4.3 Pleomorphic ...
... pleomorphic adenoma gene, zinc finger transcription factors, and an E2F-myc activator/cell cycle regulator. Many of them had ...
Myxoid leiomyosarcoma Myxoid liposarcoma Lipoblastoma Myxofibrosarcoma Myxoid cortical adenoma Pleomorphic adenoma ...
Colorectal adenocarcinoma is distinguished from a colorectal adenoma (mainly tubular and ⁄or villous adenomas) mainly by ... and pleomorphic cells with abundant vacuolated or eosinophilic cytoplasm and single or multiple vescicular nuclei with ... Precancer - Colorectal villous adenoma A lesion at least "high grade intramucosal neoplasia" (high grade dysplasia) has: Severe ... "Colorectal Adenoma Containing Invasive Adenocarcinoma". Stanford University School of Medicine. Finlay A Macrae. "Overview of ...
"Parapharyngeal Pleomorphic Adenoma" at the 3rd International Congress on Salivary Gland Diseases" in Geneva, Switzerland. He's ...
For example, benign pleomorphic salivary gland tumors may have some tumors cells that form pseudocartilage. Yet, all the tumor ... ISBN 978-92-832-2412-9. Thompson LD, Nelson BL, Barnes EL (Mar 2004). "Ceruminous adenomas: a clinicopathologic study of 41 ...
Cite this page: Pernick N. Pleomorphic adenoma-eyelid. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ ...
Keywords: Notch1, pleomorphic adenoma, cell differentiation, immunohistochemistry Introduction. Pleomorphic adenoma (PA) is the ... 1. Eveson JW, Kusafuka K, Stenman G, Nagano T. Pleomorphic adenoma. In: (ed.) Barnes L, Eveson JW, Reichart P, Sidransky D. ... Ihrler S, Schwarz S, Zengel P, Guntinas-Lichius O, Kirchner T, Weiler C. Pleomorphic adenoma: Pitfalls and clinicopathological ... Notch as a Possible Cell Differentiation Factor in Pleomorphic Adenomas Keisuke Takamine1, Yukiko Ueda1, Keisuke Nakano1, 2, ...
A late solitary liver metastasis from pleomorphic salivary adenoma - Chirurgia 2019 October;32(5):253-8 - Minerva Medica - ... Metastasizing pleomorphic salivary adenoma is extremely rare, occurring in less than 1% of patients with pleomorphic adenoma. ... Pleomorphic adenoma (also known as mixed tumour) is the most common neoplasm of the salivary glands. It is usually a benign, ... A late solitary liver metastasis from pleomorphic salivary adenoma. Nicolò FABBRI ✉ 1, Domenico REALE 2, Gloria FERROCCI 1, ...
QUEIROZ, Christiano Sampaio et al. An unusual pleomorphic adenoma. RGO, Rev. gaúch. odontol. (Online) [online]. 2014, vol.62, n ... Pleomorphic adenoma is the most common neoplasm in major and minor salivary glands. It constitutes approximately 90% of all ... The aim of this study is to report a case of an unusual minor salivary gland pleomorphic adenoma in the hard palate, describing ...
Pleomorphic Adenomas are thought to arise from the salivary gland myoepithelial cell and typically occur in the parotid glands ... However, although typically benign, pleomorphic adenomas can recur after excision and rarely can undergo malignant ...
Pleomorphic Adenoma in Cheek: An Uncommon Finding.. Authors: Pillai, Ajay Kumar. Satpathy, Mrinal. Nahar, Saksham. Moghe, ... Pleomorphic adenoma (PA), also called benign mixed tumor, is the most common benign salivary gland neoplasm. About 90% of these ... Pleomorphic Adenoma in Cheek: An Uncommon Finding. IJSS Case Reports & Reviews. 2014 May; 1(1): 19-22. ...
Causes of Pleomorphic Adenoma. Pleomorphic adenomas may occur at any age, but the highest incidence is in the third to sixth ... which are metastasizing pleomorphic adenoma (MPA), carcinoma ex pleomorphic adenoma, and true malignant mixed tumor ( ... Tags:Pleomorphic adenomaTumor of salivary glands Leave a Reply Cancel reply. Your email address will not be published. Required ... Pleomorphic adenoma is seen more often in females than in males (2:1 ratio). The cause of this tumor is mostly unknown but few ...
... Journal: International Journal of Science and Research (IJSR) ( ... of all head and neck tumors and benign pleomorphic adenoma (PA) of minor salivary glands arising de novo is very rare. PA is ...
Pleomorphic adenoma non surgical treatment. 5 thoughts on "Gerendás prosztata adenoma kezelés". Pathol Oncol Res ; 18 4 :Oct. ... Controversies in the Management of Parotid Tumors - Management of Recurrent Pleomorphic Adenoma. ... prosztata és húgyúti adenoma, Milyen gyógyszerek a prosztatagyulladás és az adenoma ellen ... Currently, based on these parameters, adenomas are characterized as "non-advanced or advanced" and patient surveillance is ...
Pleomorphic Adenoma of Both Hard And Soft Palate - A Case Report.. Authors: singh, Ratnarenu Baliar. Baliarsingh, R R. Satpathy ... Pleomorphic adenoma of major salivary gland like parotid is most common and generally it affect the superficial lobe of the ... Singh Ratnarenu Baliar, Baliarsingh R R, Satpathy A K, Naik C B, Nayak A, Lohar T P, Parida A. Pleomorphic Adenoma of Both Hard ... We have encountered a pleomorphic adenoma of minor salivary gland of posterior part of hard palate in young female patient and ...
Biopsy of soft palatal tumor showed pleomorphic adenoma. Magnetic resonance imaging showed a tumor involving left maxilla, and ... Carcinoma ex pleomorphic adenoma (CXPA) is an aggressive salivary gland malignancy and rare in minor salivary gland. A soft ... H&E, 100×), (C) The carcinoma ex pleomorphic adenoma consisting benign pleomorphic adenoma and poorly differentiated carcinoma ... Carcinoma ex pleomorphic adenoma (CXPA) is an aggressive salivary gland malignancy and rare in minor salivary gland. A soft ...
Pleomorphic adenoma (PA), also called benign mixed tumor, is the most common tumor of the salivary glands. About 70 % of these ... Here we report a case of pleomorphic adenoma of minor salivary glands of the cheek in a 22-year-old male. The mass was removed ... Pleomorphic Adenoma of the Cheek. Case Report with Review. 2020 • Volume 14 • Issue 4. Soukayna Bahbah & Saliha Chbicheb ... BAHBAH, S. & CHBICHEB, S. Pleomorphic adenoma of the cheek. Case report with review. Int. J. Odontostomat., 14(4):653-657, 2020 ...
Intraoral Pleomorphic Adenoma in Young Patients.. Alves, Violante Lina Assunção; Pérez-de-Oliveira, Maria Eduarda; de Castro, ... Intraoral pleomorphic adenoma (PA) is rare in young individuals, with only single clinical reports or small patient series ... Adenoma Pleomorfo/cirurgia Neoplasias Bucais/cirurgia Adenoma Pleomorfo/patologia Adolescente Feminino Humanos Lábio Masculino ...
PLEOMORPHIC ADENOMA GENE-LIKE 1. Gene and Variant Databases. *NCBI Gene *ClinVar ...
The aim of this study is to describe the clinicopathological characteristics of intranasal pleomorphic adenomas (PAs), as well ... The aim of this study is to describe the clinicopathological characteristics of intranasal pleomorphic adenomas (PAs), as well ... Endoscopic Endonasal Resection of Sinonasal and Nasopharyngeal Pleomorphic Adenomas: A Case Series. Karligkiotis, Apostolos; ...
... pleomorphic adenoma, surgical excision. How to cite this article:. Sharma Y, Maria A, Chhabria A. Pleomorphic adenoma of the ... SOFT PALATE PLEOMORPHIC ADENOMA OF MINOR SALIVARY GLAND. Manish Ranjan, Vineet Sinha, Amit Kumar, Surbhi Surbhi, Abhishek ... Novel Approach for Management of Extremely Rare Pleomorphic Adenoma of Soft Palate (Minor Salivary Glands). ... Pleomorphic adenoma of the palate. Yogesh Sharma1, Anisha Maria2, Amit Chhabria2. 1 PDA, Bhopal, Department of Oral Surgery, ...
Lymph node at the periphery of the parotid gland that could be mistaken for a pleomorphic adenoma. Biopsy showed a ... Lymph node at the periphery of the parotid gland that could be mistaken for a pleomorphic adenoma. Biopsy showed a ...
... as a key gene in invasive malignant pleomorphic adenoma *Zhenyuan Han ... Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barretts epithelium. ...
The other 2 forms are carcinoma ex pleomorphic adenoma and metastasizing benign pleomorphic adenoma. ... Different patterns of malignant change occur in pleomorphic adenoma, of which true malignant mixed tumor (carcinosarcoma) is ... Many of the patients had a history of pleomorphic adenoma, recurrent pleomorphic adenoma, or recurrent carcinoma ex pleomorphic ... The other 2 forms are carcinoma ex pleomorphic adenoma and metastasizing benign pleomorphic adenoma. ...
And by this, we mean pleomorphic adenoma, basal cell adenoma, or adenoid cystic carcinoma, right? But thats like inherent in ... but it actually had lung adenoma on it. Cut the brain on it, and then looked at the lung adenoma. That patient had a history of ...
Pleomorphic adenoma of the lateral nasal wall: case report. Sciandra D, Dispenza F, Porcasi R, Kulamarva G, Saraniti C. ...
Categories: Adenoma, Pleomorphic Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Background : Pleomorphic adenoma (PA) is a benign tumour of the salivary gland with a tendency to malignancy which creates many ... Isoenzymes of N-acetyl-β-hexosaminidase in human pleomorphic adenoma and healthy salivary glands: a preliminary study. ...
Pleomorphic adenoma: the great mimicker of malignancy. Histopathology. 2021 Sep.79(3):279-290. Pubmedid: 33368685. ... Asa SL, Arkun K, Tischler AS, Qamar A, Deng FM, Perez-Ordonez B, Weinreb I, Bishop JA, Wenig BM, Mete O. Middle Ear "Adenoma": ... Sclerosing Polycystic Adenoma: Conclusive Clinical and Molecular Evidence of Its Neoplastic Nature. Head Neck Pathol. 2022 Jun. ...
Pleomorphic adenoma has a good prognosis, but it has a tendency for recurrence (up to 44%) if not treated thoroughly. The risk ... Pleomorphic adenoma is the most common benign salivary gland neoplasm of both the major and minor salivary glands. It ... The clinical history of twenty years presence supports a diagnosis of a pleomorphic adenoma (MT) while the clinical history of ... symptoms and ulceration also consistent with carcinoma ex pleomorphic adenoma. For all these reasons, this condition is the ...
Eighty percent of parotid tumors are benign (55% pleomorphic adenoma, 8% Warthin s), 60% of submandibular, 50% of minor ...
Some pleomorphic adenomas of the breast share PLAG1 rearrangements with the analogous tumour of the salivary glands.. ... Pleomorphic adenoma: the great mimicker of malignancy.. Histopathology. 2021;79:279-290.. PubMed Abstract available. *BISHOP JA ...
Pleomorphic adenomas of the lacrimal gland are less common. When symptomatic, sphenoid wing meningiomas are treated with ... Cavernous venous malformations (the most common benign orbital tumor) and lacrimal gland pleomorphic adenomas are excised. ...
  • Pleomorphic adenoma (PA) is the most common salivary gland tumor classified as benign epithelial tumors ( 1 ). (medsci.org)
  • Other rarer benign salivary gland tumors include Warthin tumor, basal cell adenoma, and canalicular adenoma. (usmlepearls.com)
  • Neoplasms of the salivary glands account for less than 1 % of all tumors, 35 % of all head and neck tumors and benign pleomorphic adenoma (PA) of minor salivary glands arising de novo is very rare. (researchbib.com)
  • Pleomorphic adenoma (PA) is the most common salivary gland tumor, accounting for about 40-70% of all major and minor salivary gland tumors. (njms.in)
  • Eighty percent of parotid tumors are benign (55% pleomorphic adenoma, 8% Warthin s), 60% of submandibular, 50% of minor salivary glands, and 10% of sublingual. (vesalius.com)
  • The intranasal pleomorphic adenoma is very unusual and the cases described in the local literature address septal tumors. (bvsalud.org)
  • The most common benign tumor is pleomorophic adenoma, and the most common malignant tumor is the mucoepidermoid carcinoma What is parotid tumor Parotid tumors are the most common type of salivary gland tumors, accounting for 80 to 85 percent of all salivary gland tumors. (dannytreti.com)
  • Pleomorphic adenoma (PA), also called benign mixed tumor, is the most common benign salivary gland neoplasm. (who.int)
  • Pleomorphic adenoma is a benign salivary gland tumor. (usmlepearls.com)
  • KRAS mutation is very strongly associated with a villous architecture and through villous component expansion, KRAS mutations may increase risk of tumor progression in sporadic colorectal polypoid adenomas. (railpixel.hu)
  • Biopsy of soft palatal tumor showed pleomorphic adenoma. (biomedcentral.com)
  • Pleomorphic adenoma (PA) can be defined as a benign mixed tumor composed of epithelial and myoepithelial cells arranged with various morphological patterns, demarcated from surrounding tissues by fibrous capsule. (njms.in)
  • Different patterns of malignant change occur in pleomorphic adenoma , of which true malignant mixed tumor (carcinosarcoma) is one form. (medscape.com)
  • The most common benign tumor of the parotid gland is the Pleomorphic Adenoma Pleomorphic Adenoma which is also called a Benign Mixed Tumor. (dannytreti.com)
  • Tumor benigno de crecimiento lento, que suele afectar a las glándulas salivales, en forma de nódulo pequeño, firme e indoloro. (bvsalud.org)
  • Carcinoma ex pleomorphic adenoma (CXPA) is an aggressive salivary gland malignancy and rare in minor salivary gland. (biomedcentral.com)
  • A) Pleomorphic adenoma in a chondromyxoid, fibrotic and sclerotic stroma with the malignant areas of carcinoma component consisting epithelial clusters with necrosis. (biomedcentral.com)
  • H&E, 40×), (B) Carcinoma component is composed of cells with pleomorphic nucleus, mitotic activity and comedo-like necrosis. (biomedcentral.com)
  • The other 2 forms are carcinoma ex pleomorphic adenoma and metastasizing benign pleomorphic adenoma . (medscape.com)
  • Many of the patients had a history of pleomorphic adenoma, recurrent pleomorphic adenoma, or recurrent carcinoma ex pleomorphic adenoma. (medscape.com)
  • The clinical history of twenty years' presence supports a diagnosis of a pleomorphic adenoma (MT) while the clinical history of recent changes, symptoms and ulceration also consistent with carcinoma ex pleomorphic adenoma. (washington.edu)
  • Poorly differentiated squamous cell carcinoma of the Skin with adenoma hypophysis pathology large nuclei and many mitotic figures. (dekormatrica.hu)
  • http://www.cxpacancer.com Thankfully, we have connected with a few wonderful people who've been impacted by carcinoma ex pleomorphic adenoma. (richardwhayes.com)
  • Pleomorphic adenoma is the most common neoplasm in major and minor salivary glands. (bvsalud.org)
  • Here we report a case of pleomorphic adenoma of minor salivary glands of the cheek in a 22-year-old male. (ijodontostomatology.com)
  • IMSEAR at SEARO: Pleomorphic Adenoma in Cheek: An Uncommon Finding. (who.int)
  • The aim of this study is to describe the clinicopathological characteristics of intranasal pleomorphic adenomas (PAs), as well as the role and outcomes of endoscopic endonasal resection. (hunimed.eu)
  • This may be the cause of the recurrence of pleomorphic adenomas in cases that were treated with simple enucleation or in cases in which surgical resection was performed with inadequate surgical margins. (usmlepearls.com)
  • We have encountered a pleomorphic adenoma of minor salivary gland of posterior part of hard palate in young female patient and it was excised with definitive margin with no recurrence. (who.int)
  • Pleomorphic adenoma has a good prognosis, but it has a tendency for recurrence (up to 44%) if not treated thoroughly. (washington.edu)
  • Although malignant change in the sclerotic variant of neurofibroma has not been reported previously, in the case reported here incomplete excision due to an ill-defined border caused 3 instances of recurrence, which probably resulted in malignant change, as has been shown in pleomorphic adenoma (4). (medicaljournals.se)
  • A clinical case is presented of a patient who consulted for unilateral right nasal obstruction associated with epistaxis and ipsilateral epiphora with imaging study and biopsy suggesting pleomorphic adenoma of the lateral nasal wall. (bvsalud.org)
  • Some pleomorphic adenomas of the breast share PLAG1 rearrangements with the analogous tumour of the salivary glands. (amedeo.com)
  • The pleomorphic adenoma gene 1 (Plag1) proto-oncogene encodes a transcription factor and is implicated in human tumorigenesis via ectopic overexpression. (pasteur.fr)
  • Pleomorphic adenoma (also known as mixed tumour) is the most common neoplasm of the salivary glands. (minervamedica.it)
  • ABSTRACT The pleomorphic adenoma is the most frequent benign neoplasm of the major salivary glands. (bvsalud.org)
  • The aim of this study is to report a case of an unusual minor salivary gland pleomorphic adenoma in the hard palate, describing the most important aspects of this pathology. (bvsalud.org)
  • Pleomorphic Adenoma of Both Hard And Soft Palate - A Case Report. (who.int)
  • Singh Ratnarenu Baliar, Baliarsingh R R, Satpathy A K, Naik C B, Nayak A, Lohar T P, Parida A. Pleomorphic Adenoma of Both Hard And Soft Palate - A Case Report. (who.int)
  • The liver tumour was found to be a very large metastasis of pleomorphic adenoma with unharmed resection margins. (minervamedica.it)
  • The tail of the superficial lobe of the parotid salivary gland is the most common site of occurrence for pleomorphic adenoma (70-80% of cases), although this lesion can occur in any parotid location. (usmlepearls.com)
  • Histopathologic report showed the presence of myoepithelial cells and ducts lined by cuboidal cells and it confirmed the lesion to be "pleomorphic adenoma" [Figure 4] . (njms.in)
  • Fine Needle aspiration: pleomorphic adenoma is made through straightforward microscopic identification. (usmlepearls.com)
  • However, although typically benign, pleomorphic adenomas can recur after excision and rarely can undergo malignant transformation. (pathwaymedicine.org)
  • It is known that pleomorphic adenoma, a benign tumour of the salivary gland, shows malignant change after incomplete excision (4). (medicaljournals.se)
  • RESUMEN El adenoma pleomorfo constituye la neoplasia benigna más frecuente de las glándulas salivales mayores, y puede también presentarse en otros sitios con mucha menor frecuencia como orofaringe, hipofaringe y nasofaringe. (bvsalud.org)
  • El adenoma pleomorfo intranasal es muy infrecuente y los casos descritos en la literatura local se refieren a tumores septales. (bvsalud.org)
  • Se presenta un caso clínico de una paciente que consulta por obstrucción nasal unilateral a derecha asociado a, epistaxis y epífora ipsilateral con estudio imagenológico y biopsia que sugiere adenoma pleomorfo de la pared lateral nasal. (bvsalud.org)
  • The expression of Notch in 30 cases of pleomorphic adenoma was examined by immunohistochemistry. (medsci.org)
  • Szürkehályog optikai szonda Pituitary Adenoma: Diagnosis. (dekormatrica.hu)
  • Pleomorphic Adenomas are thought to arise from the salivary gland myoepithelial cell and typically occur in the parotid glands. (pathwaymedicine.org)
  • Pleomorphic adenomas may occur at any age, but the highest incidence is in the third to sixth decades of life. (usmlepearls.com)
  • Adenoma hypophysis pathology. (dekormatrica.hu)
  • Among the cords, there are sinusoidal capillaries Presence adenoma hypophysis pathology numerous Neutrophil in the blood Leukemia blood cells medical science background concept. (dekormatrica.hu)
  • A pituitary adenoma may be suspected based on symptoms, the medical history, and physical findings. (dekormatrica.hu)
  • Metastasizing pleomorphic salivary adenoma is extremely rare, occurring in less than 1% of patients with pleomorphic adenoma. (minervamedica.it)
  • Intraoral Pleomorphic Adenoma in Young Patients. (bvsalud.org)
  • Intraoral pleomorphic adenoma (PA) is rare in young individuals, with only single clinical reports or small patient series reported previously. (bvsalud.org)
  • The aim of this study was to investigate the correlation between the KRAS mutations and characteristics of non-advanced and advanced colorectal adenomas for predicting the risk of increased malignant potential of adenomas that may influence the decision to offer follow-up endoscopic surveillance. (railpixel.hu)
  • Primary Pleomorphic Adenoma of the External Auditory Canal-A Case Report and Literature Review. (aimdrjournal.com)
  • Pleomorphic adenoma of major salivary gland like parotid is most common and generally it affect the superficial lobe of the gland. (who.int)
  • Pleomorphic adenomas of the lacrimal gland are less common. (merckmanuals.com)
  • All cases were resected 'en bloc' with endoscopic endonasal approach. (hunimed.eu)
  • Currently, based on these parameters, adenomas are characterized as "non-advanced or advanced" and patient surveillance is adjusted accordingly. (railpixel.hu)