Adenoma: A benign epithelial tumor with a glandular organization.Adenoma, Pleomorphic: A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)Adenoma, Villous: An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.Adrenocortical Adenoma: A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.Adenoma, Liver Cell: A benign epithelial tumor of the LIVER.Adenoma, Chromophobe: A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.Growth Hormone-Secreting Pituitary Adenoma: A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Colonic Polyps: Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.ACTH-Secreting Pituitary Adenoma: A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.Adenoma, Acidophil: A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)Colonoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the colon.Adenomatous Polyps: Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)Prolactinoma: A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.Adenoma, Basophil: A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Adenomatous Polyposis Coli: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.Genes, APC: Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.Hyperparathyroidism: A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Colonic Neoplasms: Tumors or cancer of the COLON.Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Adrenal Gland Neoplasms: Tumors or cancer of the ADRENAL GLANDS.Pituitary ACTH Hypersecretion: A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Hyperaldosteronism: A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.Sphenoid Bone: An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Pituitary Gland: A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Hyperparathyroidism, Primary: A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Sella Turcica: A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND.Sigmoidoscopy: Endoscopic examination, therapy or surgery of the sigmoid flexure.Choristoma: A mass of histologically normal tissue present in an abnormal location.Rectal Neoplasms: Tumors or cancer of the RECTUM.Pituitary Apoplexy: The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.Human Growth Hormone: A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Pituitary Hormones: Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.Adenomatous Polyposis Coli Protein: A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.Parathyroidectomy: Excision of one or more of the parathyroid glands.Urethane: Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Adenoma, Bile Duct: A benign tumor of the intrahepatic bile ducts.Prolactin: A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.Colon, Descending: The segment of LARGE INTESTINE between TRANSVERSE COLON and the SIGMOID COLON.
Salivary gland tumors in Jordan: a retrospective study of 221 patients. (1/197)
AIM: To evaluate the types and clinical outcome of salivary gland tumors in Jordan. METHODS: Hospital records of 221 patients (85 women and 136 men) with salivary gland tumors, diagnosed from January 1988 to December 1997 were reviewed. The patients were analyzed according to sex, age, histopathological type and site of the tumor. Survival curves for patients with malignant tumors were constructed using Kaplan-Meier's method. RESULTS: Of the total 221 salivary gland tumors, 155 (70.2%) were parotid tumors, 42 (19%) minor salivary gland tumors, 23 (10.4%) submandibular gland tumors, and a single (0.4%) sublingual gland tumor. Most of the tumors (151, or 68.4%) were classified as benign and 70 (31.6%) were malignant. Men to women ratio was 1.6:1, and the age of the patients ranged from 2 to 81 years. The overall 5 and 10 year-survival rates for the 70 malignant tumors were 67% and 53%, respectively, for all tumor stages. Mucoepidermoid carcinoma had the best, and squamous cell carcinoma the worst 10-year survival rate. Patients treated with surgery and subsequent radiation therapy had better survival rates than those treated with surgery or radiation therapy alone. CONCLUSION: The principal site for salivary gland tumors in Jordan population was the parotid, and the pleo- morphic adenoma the most common pathological finding. Tumor characteristics and survival data for the Jordanian population are comparable to those from western countries. (+info)Clinically benign parotid tumours: local dissection as an alternative to superficial parotidectomy in selected cases. (2/197)
In a personal series of 162 tumours, 101 were pleomorphic adenomas 28 of which were removed by elective local extra capsular dissection and 73 by a conventional nerve dissection. There were no recurrences in either group after a mean follow-up 10.3 years, range 3-21 years for local dissection and 8.3 years, range 3-22 years for nerve dissection. Frey's syndrome did not occur after local dissection but was present in 25% of patients after a nerve dissection. Of the 162 parotid lumps, 17 proved to be a carcinoma but only one was deemed suitable for a local removal, a low grade muco epidermoid carcinoma of the accessory lobe and no recurrence has occurred after 8 years. In benign disease, local dissection gives similar results to conventional nerve dissection with less morbidity and confirms that tumour recurrence cannot be ascribed to any properties of the tumour but lies in the hands of the surgeon and depends on the care with which the tumour is removed. (+info)PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. (3/197)
PLAG1, a novel developmentally regulated C2H2 zinc finger gene, is consistently rearranged and overexpressed in pleomorphic adenomas of the salivary glands with 8q12 translocations. In this report, we show that PLAG1 is a nuclear protein that binds DNA in a specific manner. The consensus PLAG1 binding site is a bipartite element containing a core sequence, GRGGC, and a G-cluster, RGGK, separated by seven random nucleotides. DNA binding is mediated mainly via three of the seven zinc fingers, with fingers 6 and 7 interacting with the core and finger 3 with the G-cluster. In transient transactivation assays, PLAG1 specifically activates transcription from its consensus DNA binding site, indicating that PLAG1 is a genuine transcription factor. Potential PLAG1 binding sites were found in the promoter 3 of the human insulin-like growth factor II (IGF-II) gene. We show that PLAG1 binds IGF-II promoter 3 and stimulates its activity. Moreover, IGF-II transcripts derived from the P3 promoter are highly expressed in salivary gland adenomas overexpressing PLAG1. In contrast, they are not detectable in adenomas without abnormal PLAG1 expression nor in normal salivary gland tissue. This indicates a perfect correlation between PLAG1 and IGF-II expression. All of these results strongly suggest that IGF-II is one of the PLAG1 target genes, providing us with the first clue for understanding the role of PLAG1 in salivary gland tumor development. (+info)Cartilage-specific matrix protein chondromodulin-I is associated with chondroid formation in salivary pleomorphic adenomas: immunohistochemical analysis. (4/197)
Chondromodulin-I (ChM-I) is a novel cartilage-specific matrix protein. In the growth plates of the long bones, ChM-I was shown to be expressed in mature to upper hypertrophic chondrocytes, and to be deposited in the cartilage matrix. As ChM-I strongly inhibits angiogenesis, cartilage is avascular. Also, ChM-I has bifunctional activity against chondrocyte proliferation. On the other hand, pleomorphic adenomas of the salivary glands frequently have chondroid elements. To elucidate the relationship between chondroid formation and hypovascularity in salivary pleomorphic adenomas, we immunohistochemically examined the expression and localization of ChM-I in 35 cases of this tumor. ChM-I was immunolocalized to the lacunae in the chondroid elements of pleomorphic adenomas (100%). Type II collagen and aggrecan were immunolocalized throughout the matrix around lacuna cells of the chondroid element (100%, 91.7%), and ChM-I was infrequently immunolocalized to the spindle-shaped myoepithelial cells in the myxoid element (37.5%). Fibroblast growth factor-2 was strongly immunolocalized to the lacuna cells in the chondroid element (100%), among the neoplastic myoepithelial cells in the myxoid elements (96.9%), and on the basement membranes around the solid nests of neoplastic myoepithelial cells (71.4%). Although CD34 is a marker of endothelial cells, CD34 was expressed in the endothelial cells in only a few areas around the epithelial elements and in the fibrous element of pleomorphic adenomas. No signals for CD34 were observed in chondroid elements in pleomorphic adenomas (P < 0.001), but a few signals were seen in the myxoid elements (P < 0.05). These findings suggested that lacuna cells and neoplastic myoepithelial cells expressed ChM-I, and that this molecule may play an important role in hypovascularity and chondroid differentiation in pleomorphic adenoma. In conclusion, pleomorphic adenoma expressed ChM-I, which is involved in hypovascularity and chondroid formation in this type of tumor. (+info)Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature. (5/197)
Epithelial-myoepithelial tumors of the lung are rare neoplasms whose biological behavior and clinical course still remain to be defined. A case of epithelial-myoepithelial tumor of the lung arising from bronchial mucosa-submucosa and occurring as a polypoid lesion of the upper left bronchus in a 47-year-old man is reported. The tumor did not infiltrate the cartilaginous wall of the bronchus and showed a biphasic histological appearance with a double layering of epithelial and myoepithelial cells. Myoepithelial spindle cells with eosinophilic cytoplasm were also observed. Mitotic figures were very rare and necrosis absent. Immunohistochemical study for epithelial and muscular markers confirmed the presence of a double-cell component in the tumor, namely epithelial and myoepithelial. The patient is alive and well, with no evidence of recurrent or metastatic disease 6 months after surgery. On the basis of the present case and the six previously reported cases, we suggest using the noncommittal term pulmonary epithelial-myoepithelial tumor of unproven malignant potential (PEMTUMP) for this type of neoplasm. In addition, we first introduce p63 as a novel marker for highlighting the myoepithelial cells of the respiratory tract and speculate on the role of these cells in the development of this unusual tumor. (+info)High-dose-rate endobronchial brachytherapy in endobronchial metastatic malignant chondroid syringoma. (6/197)
A 65-year-old man with malignant chondroid syringoma (MCS) was found to have pulmonary metastases in the form of multiple pulmonary nodules 4 years after wide excision and adjuvant radiotherapy of a primary abdominal wall tumor. Atelectasis of the lingula due to obstructive endobronchial metastasis, resistant to combination chemotherapy, led us to perform high-dose rate (HDR) endobronchial brachytherapy for the first time in this rare tumor with a favorable response. This case emphasizes the role of HDR brachytherapy as a palliative procedure in endobronchial tumors not responding to other treatment modalities, even those considered to be radioresistant. (+info)Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma. (7/197)
Carcinoma ex pleomorphic adenoma (CexPA) is a carcinoma developing within a pre-existing benign pleomorphic adenoma (PA). Here we describe the identification and characterization of a series of genetic events leading to translocation, deletion/amplification, and overexpression of the HMGIC and MDM2 genes in a CexPA at an early stage of development. The tumor had a pseudodiploid stemline karyotype with a del(5)(q22-23q32-33) and a t(10;12)(p15;q14-15). In addition, there were several sidelines with double minute chromosomes (dmin) or homogeneously staining regions (hsr). Fluorescence in situ hybridization (FISH) mapping revealed that the 12q14-15 breakpoint was located centromeric to HMGIC and that the entire gene was juxtaposed to the der(10) chromosome. Detailed analysis of cells with dmin and hsr revealed that HMGIC and MDM2 were deleted from the der(10) and that the dmin and hsr were strongly positive for both genes. Southern blot analysis confirmed that both HMGIC and MDM2 were amplified and that no gross rearrangements of the genes had occurred. Immunostaining revealed that the HMGIC protein was highly overexpressed particularly in the large polymorphic cells within the carcinomatous part of the tumor. These findings suggest that amplification and overexpression of HMGIC and possibly MDM2 might be important genetic events that may contribute to malignant transformation of benign PA. (+info)Intraosseous pleomorphic adenoma: case report and review of the literature. (8/197)
Pleomorphic adenoma is the most common neoplasm of the salivary glands, affecting mainly the parotid gland. The preferential intraoral site of this tumor is the palate. A case of a 31-year-old woman with an intraosseous pleomorphic adenoma located in the maxilla (left paramedian region), showing an approximate evolution of one year is reported. The present intraosseous case represents a rare location, with the tumor probably originating from glandular epithelial remnants captured during embryogenesis. In a review of the literature of 142 cases of intragnathic localization (24% in the maxilla) are identified. A slight predominance of women was observed (56%), with 55% of the patients being affected during the 5th to 7th decade of life. The tumors were malignant in 94% of the cases, with special predominance of mucoepidermoid carcinoma (65%). Intraosseous pleomorphic adenomas are rare, with the present patient being the 6th case reported in the literature and the second found in the maxilla. Mean age of the 5 previously reported cases was 58.8 years. (+info)Pleomorphic adenoma • Pleurodont • Plica fimbriata • Polk E. Akers • Polymorphous low-grade adenocarcinoma • Polynoxylin • ... Canalicular adenoma • Canine tooth • Cantilever mechanics • Carbon dioxide laser • Caries vaccine • Carnassial • Case School of ...
Summary: Associated Cancers: colorectal and ovarian cancer; pilomatrixoma; medulloblastoma; pleomorphic adenomas; malignant ... pleomorphic adenomas, and malignant mesothelioma. While less is known about the exact mechanism of α-catenin, its presence in ... "The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the β-catenin signaling pathway". ...
Pleomorphic adenoma. References[edit]. *^ Witt, Robert L., ed. (2005). "Chapter 9 "Benign tumors, cysts, and tumor-like ... Though much less likely to occur than pleomorphic adenoma, Warthin's tumor is the second most common benign parotid tumor. ...
Pleomorphic adenoma Witt, Robert L., ed. (2005). "Chapter 9 "Benign tumors, cysts, and tumor-like conditions of the salivary ... Though much less likely to occur than pleomorphic adenoma, Warthin's tumor is the second most common benign parotid tumor. Its ...
Examples include pleomorphic adenoma and Mixed Müllerian tumor. Pleomorphism Mixed tumor "mixed tumor - definition of mixed ...
Lacrimal Gland Histology Pleomorphic adenoma of Krause's gland. ...
PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, salivary gland pleomorphic; 181030; PLAG1 Adenomatous polyposis ... TCF4 Pituitary adenoma, ACTH-secreting; 219090; AIP Pituitary adenoma, growth hormone-secreting; 102200; AIP Pituitary adenoma ... EIF2B4 Leydig cell adenoma, somatic, with precocious puberty; 176410; LHCGR Leydig cell hypoplasia with hypergonadotropic ... SCN4A Parathyroid adenoma with cystic changes; 145001; HRPT2 Parathyroid carcinoma; 608266; HRPT2 Parietal foramina 1; 168500; ...
2008). "Tenascin and fibronectin expression in carcinoma ex pleomorphic adenoma". Appl. Immunohistochem. Mol. Morphol. 16 (1): ...
The histologic differential diagnosis includes adenoid cystic carcinoma and pleomorphic adenoma. They generally have a good ...
8, 17 and vimentin in pleomorphic adenoma of the salivary glands]". Arkh. Patol. 51 (10): 28-35. PMID 2482017. Eichbaum QG, ...
The most common form of benign parotid neoplasms are pleomorphic adenomas. The most common form of malignant parotid neoplasms ...
About 40-60% of SDC arise in pleomorphic adenomas. Most, if not all, SDCs express androgen receptor by immunohistochemistry. ... "Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and ...
The benign tumors include ceruminous adenoma, ceruminous pleomorphic adenoma, and ceruminous syringocystadenoma papilliferum. ...
1998). "Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas". Oncogene. 16 (7): 865 ...
Microscopically, its histology can be confused with an adenoid cystic carcinoma and a pleomorphic adenoma. PLGAs are treated ...
"PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using ... Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is ... Voz ML, Agten NS, Van de Ven WJ, Kas K (2000). "PLAG1, the main translocation target in pleomorphic adenoma of the salivary ... in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter". Oncogene. 16 (11 ...
... and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma". Am. J. Pathol. 160 (2): 433-40. doi:10.1016/S0002-9440 ... The same mutations that lead to pituitary adenomas in mice can be found in similar cancers in humans. Its presence is ... Fedele M, Pierantoni GM, Visone R, Fusco A (September 2006). "Critical role of the HMGA2 gene in pituitary adenomas". Cell ... "Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas". Oncogene. 21 (20): 3190-8. doi: ...
Other suggestions included ameloblastoma or a benign salivary mixed tumor (also known as a pleomorphic adenoma). In the 1980s, ...
It is important that other tumors such as pleomorphic adenoma, basal cell adenoma, adenoid cystic carcinoma, and teratoma be ... "congenital pleomorphic adenoma"). A clinicopathologic, immunohistochemical and ultrastructural study of nine cases". Am J Surg ... It has previously been referred to as congenital basal cell adenoma, embryoma, or basaloid adenocarcinoma. It is an extremely ... Seifert, G.; Donath, K. (1997). "The congenital basal cell adenoma of salivary glands. Contribution to the differential ...
They included pleomorphic adenoma, myoepithelioma, myxoid neurofibroma, neurothekeoma (nerve sheath myxoma), chondroid ...
The most common of these include pleomorphic adenoma (70% of tumors, affecting predominantly females (60%)) and Warthin tumor ( ... Other malignant tumors of the parotid gland include acinic cell carcinoma, carcinoma expleomorphic adenoma, adenocarcinoma ( ...
... an example of this is the pleomorphic adenoma of the sexual reproduction salivary glands.. ...
2007). "Binding of pleomorphic adenoma gene-like 2 to the tumor necrosis factor (TNF)-alpha-responsive region of the NCF2 ... 2005). "Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter". Am. J. ... "Entrez Gene: PLAGL2 pleiomorphic adenoma gene-like 2". Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, ...
... pleomorphic adenoma gene-like 1). PLAG1 is a transcription regulator of the type 1 receptor for pituitary adenylated cyclase- ...
Pleomorphic Adenoma Gene (PLAG) C2H2 Zinc Finger Transcription Factors 2 (ZF02) Vertebrate SMAD Family of Transcription Factors ...
Pleomorphic anaplastic neuroblastoma, Pleomorphic xanthoastrocytoma, Primary central nervous system lymphoma, Sphenoid wing ... Pituitary adenomas ("pituitary tumours") are sometimes incorrectly referred to as a brain tumours.[68][69] This is perhaps ... Most pituitary adenomas can be removed surgically, often using a minimally invasive approach through the nasal cavity and skull ... base (trans-nasal, trans-sphenoidal approach). Large pituitary adenomas require a craniotomy (opening of the skull) for their ...
Metastasizing pleomorphic adenoma is a rarely detected form of clinic antity [2,3]. According to the World… ... Pleomorphic adenoma is the most common salivary gland tumor on the head and neck region [1]. ... Pleomorphic adenoma is the most common salivary gland tumor on the head and neck region [1]. Metastasizing pleomorphic adenoma ... of the metastazing pleomorphic adenoma is related with previous pleomorphic adenoma. ...
Lymphatic vascular density and lymphangiogenesis during tumour progression of carcinoma ex pleomorphic adenoma ... Lymphatic vascular density and lymphangiogenesis during tumour progression of carcinoma ex pleomorphic adenoma ... and 10 of pleomorphic adenoma (PA) without malignant transformation, lymphatic vessels and proliferating cells were detected ... and lymph vessel endothelial proliferation in a series of carcinoma ex pleomorphic adenoma (CXPA) that represents the tumour in ...
Shetty, S., Nayak, D. R., & Jaiprakash, P. (2018). Pleomorphic adenoma of nasal septum: A rare case. BMJ Case Reports, 2018, [ ... Shetty, S, Nayak, DR & Jaiprakash, P 2018, Pleomorphic adenoma of nasal septum: A rare case, BMJ Case Reports, vol. 2018, bcr ... Pleomorphic adenoma of nasal septum : A rare case. / Shetty, Shama; Nayak, Dipak Ranjan; Jaiprakash, Padmapriya. ... title = "Pleomorphic adenoma of nasal septum: A rare case",. abstract = "The most common benign tumour of the major salivary ...
His histopathology report was suggestive of pleomorphic adenoma. The swelling recurred after one year of excision and a ... His histopathology report was suggestive of pleomorphic adenoma. The swelling recurred after one year of excision and a ...
Though it is classified as a benign tumor, pleomorphic adenomas have the capacity to grow to large proportions and may undergo ... Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation of parenchymatous ... Leonetti JP, Marzo SJ, Petruzzelli GJ, Herr B (Sep 2005). "Recurrent pleomorphic adenoma of the parotid gland". Otolaryngol ... "Histopathology of pleomorphic adenoma in the parotid gland: a prospective unselected series of 100 cases". Laryngoscope. 111 ( ...
Salivary gland Pleomorphic adenoma Di Palma, S. (Jul 2013). "Carcinoma ex pleomorphic adenoma, with particular emphasis on ... Carcinoma ex pleomorphic adenoma, abbreviated ca ex PA, is a type of cancer typically found in the parotid gland. It arises ... Carcinoma ex pleomorphic adenoma is diagnosed by examining it under the microscope with consideration of the individual history ... In approximately 75% of cases ca ex PAs arise in a pleomorphic adenoma that is apparent when the tumour is excised. In the ...
Metastasizing pleomorphic adenoma is 1 of these; the other 2 are carcinoma ex pleomorphic adenoma and true malignant mixed ... There are 3 main patterns of malignant change that occur in pleomorphic adenoma. ... Pathology of metastasizing pleomorphic adenoma. The image shows metastasizing pleomorphic adenoma of the skin on the lower ... Metastasising pleomorphic salivary adenoma: a rare case report of a massive untreated minor salivary gland pleomorphic adenoma ...
Fifty-two cases of pleomorphic adenoma of minor salivary gland origin and seventy-two cases of pleomorphic adenoma of major ... Fifty-two cases of pleomorphic adenoma of minor salivary gland origin and seventy-two cases of pleomorphic adenoma of major ... "Hyaline cells" in pleomorphic adenoma of salivary gland origin Oral Surg Oral Med Oral Pathol. 1981 Nov;52(5):506-12. doi: ...
A rare case of a benign pleomorphic adenoma is reported, arising in a parotid lymph node in a 52-year-old woman. Serial ... Takeda, Y., Suzuki, A. Benign pleomorphic adenoma arising in a parotid lymph node. Virchows Arch. A Path. Anat. and Histol. 396 ... Benign pleomorphic adenoma arising in a parotid lymph node. *Y. Takeda1. & ... A rare case of a benign pleomorphic adenoma is reported, arising in a parotid lymph node in a 52-year-old woman. Serial ...
The facial nerve provides motor innervation to the muscles of facial expression, scalp, stapedius, stylohyoideus and posterior belly of the digastric. It is sensory from the anterior 2/3 of the tongue (taste), external auditory meatus, soft palate and adjacent pharynx. It carries parasympathetic fibers which are secretomotor to the submaxillary, sublingual, lacrymal, nasal and palatine glands. It enters the substance of the parotid at the posterior border of the gland and immediately divides into a temporofacial and cervicofacial branch. Each branch subdivides into numerous nerves exiting the anterior borders of the gland to spread over the face. The marginal mandibular branch is variable, sometimes coming off the main trunk before the bifurcation. Notes ...
The facial nerve emerges at the inferior border of the pons (see brain anatomy), travels through the facial canal in the petrous portion of the temporal bone and emerges from the stylomastoid foramen. The foramen can be located by following the groove between the tympanic portion of the temporal bone and the mastoid process. The nerve is at 6:00 in relation to the ear canal. Notes ...
... pleomorphic adenoma or PA); it accounts for approximately 3-4% of all salivary gland n ... Carcinoma ex pleomorphic adenoma (CXPA) is a malignant epithelial neoplasm arising in a benign mixed tumor (i.e., ... Carcinoma ex pleomorphic adenoma (CXPA) is a malignant epithelial neoplasm arising in a benign mixed tumor (i.e., pleomorphic ... Carcinoma ex-pleomorphic adenoma of the nasal cavity: a report of two cases. J Laryngol Otol. 1995;109:677-9.PubMedCrossRef ...
A pleomorphic adenoma is a benign neoplasm that forms in the salivary gland. Although they start out benign they do have the ... While pleomorphic adenoma can occur at any age, they are most commonly diagnosed between the ages of 43 - 46. Pleomorphic ... A pleomorphic adenoma is a benign neoplasm that forms in the salivary gland. Although they start out benign they do have the ... Treatment of pleomorphic adenoma depends on the size, location and stage of the tumor. Also, if it is benign or malignant tumor ...
We report a rare case of pleomorphic adenoma arising from the lateral nasal wall. PATIENT AND METHOD: A 23year old woman ... AIM/BACKGROUND: We report a rare case of pleomorphic adenoma arising from the lateral nasal wall. PATIENT AND METHOD: A 23year ... The diagnosis, clinical behaviour and treatment of pleomorphic adenoma of the lateral nasal wall are discussed from a review of ... which are histological characteristics of pleomorphic adenoma. CONCLUSIONS: Her post-operative clinic visits were uneventful, ...
Pleomorphic adenoma. Image. Description. Pleomorphic adenoma (mixed tumor): A well circumscribed firm soft tissue enlargement ... Pleomorphic adenoma (mixed tumor): A Waters sinus radiograph of the previous patient. Note that the lesion has invaded the left ... Pleomorphic adenoma (mixed tumor): A firm well circumscribed soft tissue enlargement fills up the palatal vault. The lesion has ... Pleomorphic adenoma (mixed tumor): A microscopic image showing ducts lined by cuboidal cells, islands of epithelium, and loose ...
Pleomorphic Adenoma of the Parotid: Extracapsular Dissection Compared with Superficial Parotidectomy-A 10-Year Retrospective ... The authors carried out a retrospective cohort study of 198 patients with pleomorphic adenomas of the parotid gland. ... Extracapsular dissection may be considered the treatment of choice for pleomorphic adenomas located in the superficial portion ... rates and effectiveness of extracapsular dissection compared with superficial parotidectomy for pleomorphic adenomas of the ...
Conclusion: Metastatizing pleomorphic adenoma is a rare pathologic situation but, in case of swelling or lump appearance in ... Metastasizing pleomorphic adenomas has rarely been reported. No histologic or molecular parameters exist at the present time ... A 54-year-old woman had a superficial left parotidectomy with facial nerve preservation for pleomorphic adenoma. She developed ... patients with pleomorphic adenoma history, it should be taken in mind. ...
A review of the FNA cytologic features of this case of chordoma and of 17 consecutive cases of pleomorphic adenoma found that ... Parapharyngeal chordoma: A diagnostic challenge and potential mimic of pleomorphic adenoma on fine-needle aspiration cytology. ... A review of the literature found no previous instances in which chordomas mimicked pleomorphic adenoma on FNA. However, since ... intensely metachromatic material led to an initial diagnosis of pleomorphic adenoma. Review of the patients prior pathology ...
Treatment for Pleomorphic Adenoma. by Lee Morgan; Updated September 30, 2017 Related Articles. *Exercise Tips for Developing ... A pleomorphic adenoma is a benign tumor in the salivary glands that appears as a firm and painless mass. In rare cases these ... The most common and effective treatment for pleomorphic adenoma is a complete surgical excision of the tumor itself, according ... The WJSO reports that studies have shown a 6 to 7 percent recurrence rate for patients with benign pleomorphic adenoma. ...
Pleomorphic Adenoma Treatment in Los Angeles CA. Dr. Larian is a renowned pleomorphic adenoma treatment surgeon in Los Angeles ...
Pleomorphic adenoma of the parotid gland.. Non-contrast studies -- Sagittal SE T1-weighted MR image reveals a well- ...
Tavarez on pleomorphic adenoma hard palate: You clearly have a thyroid problem, and this needs to be discussed in context of ... Pleomorphic (Definition) We use the term pleomorphic often in pathology; it literally means "many shapes". Pleomorphic cells in ... I ve pleomorphic adenoma in parotid gland.dr performed fnac..does fnac spread tumor cells..scared.size is 1.5cm.entire gland ... Spread not likely: Pleomorphic adenoma is benign and there is minimal risk of spread with a fine needle aspirate. Removal is ...
Pleomorphic adenomas are the most common salivary gland tumours. This case was donated to Radiopaedia.org by Radswiki.net ... MRI and PET images demonstrate a right parotid pleomorphic adenoma. ... MRI and PET images demonstrate a right parotid pleomorphic adenoma. Pleomorphic adenomas are the most common salivary gland ...
Pleomorphic adenoma of the parotid gland.. Non-contrast studies -- Coronal fat-suppressed FSE T2-weighted MR image reveals a ...
Harrie R.P., Kendall C.J. (2014) Case Study 43 Pleomorphic Adenoma of Lacrimal Gland. In: Clinical Ophthalmic Echography. ...
TumorSuggestiveMetastasizingHistopathologicalCases of metastasizing pleomEpithelialRecurrencePathologyFine-needle aRecurrent pleomorphicRare case of pleomorphic adenomaCommon benign salivaryHistologicalHard PalateFeatures of pleomorphic adenomaSuggestive of pleomorphic adenomaCharacteristic of pleomorphic adenomaParotidectomyParapharyngeal2017LesionsMyoepithelial cellsSalivary gland PleomorphicCellular Pleomorphic AdenomaMetastasizing Pleomorphic AdenomaParotid and submandibular glandsDiagnosis of pleomorphicPatients with pleomorphicHistology of pleomorphicLacrimalMinor salivary glandsNasal CavityMalignancyUnusualRight parotid
- Pleomorphic adenoma is the most common salivary gland tumor on the head and neck region [ 1 ]. (medium.com)
- The biopsy from the mass was suggestive of pleomorphic adenoma and was resected endoscopically. (elsevier.com)
- Metastasizing pleomorphic adenoma is a rarely detected form of clinic antity [ 2 , 3 ]. (medium.com)
- Histopathological examination was consistent with pleomorphic adenoma. (elsevier.com)
- In a 2003 review by Nouraei et al, 42 cases of metastasizing pleomorphic adenoma were reported in the English-language literature between 1953 and 2005. (medscape.com)
- It should be noted, however, that the exact number of cases of metastasizing pleomorphic adenoma has been a matter of controversy among reviewing authors. (medscape.com)
- Tarjan G. Schwannoma including epithelial elements mimicking pleomorphic adenoma of the submandibular gland on fine-needle cytology: the first case report. (springer.com)
- Aims To investigate the clinical and imaging features of primary and recurrent lacrimal gland pleomorphic adenoma (LGPA), as well as lacrimal gland malignant epithelial tumours (LGMET). (bmj.com)
- Carcinosarcoma of the parotid gland with epithelial-myoepithelial carcinoma and pleomorphic sarcoma components. (semanticscholar.org)
- Pleomorphic adenomas (PA) are the most common benign tumours of the lacrimal gland, which exhibit pleomorphism of epithelial components. (scitechnol.com)
- Pleomorphic adenomas show a diverse histology , and may contain epithelial, myoepithelial and mesenchymal-type cells . (breast-cancer.ca)
- Unfortunately pleomorphic adenoma has a fairly high rate of recurrence. (knowcancer.com)
- The WJSO reports that studies have shown a 6 to 7 percent recurrence rate for patients with benign pleomorphic adenoma. (azcentral.com)
- Objective: This study aimed to reveal diagnosis, management, and treatment outcome characteristics of sinonasal pleomorphic adenoma and to identify predictors for disease recurrence. (elsevier.com)
- METHODS: This cross-sectional study comparatively evaluated 21 cases of pleomorphic adenomas and 21 sections of regular oral mucosa from the files of an oral pathology department. (minervamedica.it)
- The aim of this study is to report a case of an unusual minor salivary gland pleomorphic adenoma in the hard palate, describing the most important aspects of this pathology. (bvsalud.org)
- Kapila K, Mathur S, Verma K. Schwannomas: a pitfall in the diagnosis of pleomorphic adenomas on fine-needle aspiration cytology. (springer.com)
- The nodule was subjected to Fine Needle Aspiration Cytology (FNAC) and was found to be pleomorphic adenoma of minor salivary gland origin in upper lip. (scopemed.org)
- Fine needle aspiration cytology from the mass was reported as pleomorphic adenoma. (wikidot.com)
- Pleomorphic adenoma of salivary gland: To what extent does fine needle aspiration cytology reflect histopathological features? (edu.gh)
- Purpose: To evaluate the role of radiation therapy in the management of recurrent pleomorphic adenoma of the parotid gland. (elsevier.com)
- Methods and Materials: Between 1960 and 2004, 34 patients were treated with postoperative radiation therapy for recurrent pleomorphic adenoma of the parotid gland to a median dose of 5000 cGy (range, 4,500-6,000 cGy). (elsevier.com)
- Conclusion: The use of postoperative radiation therapy leads to excellent long-term local control for the treatment of recurrent pleomorphic adenoma with acceptable late toxicity. (elsevier.com)
- This study was undertaken to evaluate and concentrate on the recurrent pleomorphic adenomas (PAs) of the parapharyngeal space. (marmara.edu.tr)
- Treatment of recurrent pleomorphic adenoma]. (nih.gov)
- AIM/BACKGROUND: We report a rare case of pleomorphic adenoma arising from the lateral nasal wall. (biomedsearch.com)
- We report a rare case of pleomorphic adenoma that originated from the mucosal lining, just above the glottic area at the level of the laryngeal ventricle in a 55-year-old female patient. (ac.ir)
- A rare case of pleomorphic adenoma with mucoepidermoid metaplasia in a middle aged female is reported here. (manipal.edu)
- Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation of parenchymatous glandular cells along with myoepithelial components, having a malignant potentiality. (wikipedia.org)
- Schwannoma-like pleomorphic adenoma is a rare variant of the common benign salivary neoplasm, pleomorphic adenoma. (springer.com)
- There was associated expansion of the cavity with displacement of the nasal septum and thinning of the medial wall of the right maxillary antrum adjacent to it.The microscopic finding showed a lobular duct-like structure within a loose chondromyxoid stroma,which are histological characteristics of pleomorphic adenoma. (biomedsearch.com)
- However there are certain histological characteristics in pleomorphic adenomas, which may raise suspicion of atypia and prompt further investigation. (scitechnol.com)
- Both breast glands and salivary glands are ' tubulo-acinar ' exocrine glands ( meaning they are designed for secretion ), so it is not surprising that adenomas developing from those glands would have similar histological and morphological features . (breast-cancer.ca)
- Objective: The histological diversity encountered in pleomorphic adenoma may cause diagnostic difficulty in fine needle aspiration (FNA) cytology due to limited and selective sampling. (edu.gh)
- Conclusion: FNA cytology demonstrates well most of the histological features of pleomorphic adenoma of salivary gland and may be considered a useful tool in initial assessment of the tumour. (edu.gh)
- Pleomorphic adenoma, anterior hard palate, salivary gland. (ijop.net)
- We report the case of a 42-year old man who came with a complaint of a swelling in the anterior region of the hard palate and later diagnosed as pleomorphic adenoma based on histopathological examination. (ijop.net)
- The specimen obtained by needle biopsy shows typical histopathologic features of pleomorphic adenoma (PA). (biomedcentral.com)
- the features were suggestive of pleomorphic adenoma (PA) (Figure 2 and Figure 3). (clinmedjournals.org)
- The biopsy from the mass was suggestive of pleomorphic adenoma and was resected endoscopically. (elsevier.com)
- The classical microscopic description was applied in 1874, observing a variety of cell types as the main characteristic of pleomorphic adenoma, not just between the different samples examined but also in different parts of the same sample 6 . (bvsalud.org)
- The purpose of this study was to investigate the complication rates and effectiveness of extracapsular dissection compared with superficial parotidectomy for pleomorphic adenomas of the parotid gland from 2002 to 2012. (hindawi.com)
- Extracapsular dissection may be considered the treatment of choice for pleomorphic adenomas located in the superficial portion of the parotid gland because this technique showed similar effectiveness and fewer side effects than superficial parotidectomy. (hindawi.com)
- A 54-year-old woman had a superficial left parotidectomy with facial nerve preservation for pleomorphic adenoma. (scirp.org)
- A radical parotidectomy involving en bloc resection of the facial nerve along with deep and superficial lobes of the parotid was performed followed by radiotherapy. (plexusmd.com)
- The most common operation for pleomorphic adenoma is a superficial parotidectomy consisting of the removal of the outer part of the parotid down to the level of the facial nerve branches. (stanford.edu)
- 1. Bill E, Becelli R, Iannetti G. A primary pleomorphic adenoma of the parapharyngeal space. (ac.ir)
- Pleomorphic Adenomas of the Parapharyngeal Space - Descarga este documento en PDF. (duhnnae.com)
- Occurrence of the pleomorphic adenoma in the parapharyngeal space is a rarity. (duhnnae.com)
- Here, three giant pleomorphic adenomas of different sizes occupying the parapharyngeal space in three patients are reported. (duhnnae.com)
- A 63-year-old male presented primary pleomorphic adenomas arising de novo from minor salivary glands in the parapharyngeal space. (embj.org)
- Methods: This study comprised a retrospective review of data from seven patients with sinonasal pleomorphic adenoma who were treated by the authors at a tertiary medical center between January 2005 and May 2017. (elsevier.com)
- Orbital pleomorphic adenomas normally present as painless enlarging lesions. (scitechnol.com)
- Small, low-grade lesions can be mistaken for pleomorphic adenomas. (blogspot.com)
- The architectural patterns and cell formations in these lesions are highly varied, or ' pleomorphic ' so to speak. (breast-cancer.ca)
- However, there is some history of malignant degeneration of pleomorphic adenomas occuring in other areas of the body, and for this reason even benign pleomorphic lesions are thought to contain a slightly higher risk for breast cancer development. (breast-cancer.ca)
- Takeda Y, Shimono M. Pleomorphic adenoma with nuclear palisading of modified myoepithelial cells: histopathologic and immunohistochemical study. (springer.com)
- B: 300 μm field of view (polymorphous mixture of spindle cells in a myxoid background showing a pleomorphic matrix with myoepithelial cells surrounding ductules and merging into stroma). (scitechnol.com)
- A pleomorphic adenoma with myoepithelial differentiation is one in which there is a layer of myoepithelial cells present. (breast-cancer.ca)
- Pleomorphic adenomas which are not ' differentiated ' by a layer of myoepithelial cells are thought to be of a higher risk for malignancy, though some of these sub-categories of breast cancer have only recently been recognized. (breast-cancer.ca)
- Salivary gland Pleomorphic adenoma Di Palma, S. (Jul 2013). (wikipedia.org)
- Polymorphous Low Grade Adenocarcinoma has a Consistent p63+/p40− Immunophenotype that Helps Distinguish it from Adenoid Cystic Carcinoma and Cellular Pleomorphic Adenoma. (ac.ir)
- By definition, metastasizing pleomorphic adenoma is characterized by the presence of one or more foci of metastatic, histologically benign pleomorphic adenoma. (medscape.com)
- In the reported cases, the distribution of metastasizing pleomorphic adenoma among males and females was almost statistically equal. (medscape.com)
- The etiology of metastasizing pleomorphic adenoma is not clearly understood, but a number of theories have been put forward. (medscape.com)
- Metastasizing pleomorphic adenoma is a rarely detected form of clinic antity [ 2 , 3 ]. (medium.com)
- Metastasizing pleomorphic adenoma: a report of three casws. (ac.ir)
- Methods: May-Grünwald- Giemsa and Papanicolaou stained smears, and haematoxylin and eosin stained paraffin sections of 25 pleomorphic adenomas of parotid and submandibular glands were reviewed. (edu.gh)
- As the prior history of chordoma was not available during the rapid onsite evaluation, the presence of bland epithelioid nonvacuolated cells and spindle cells intimately admixed with a fibrillary, intensely metachromatic material led to an initial diagnosis of pleomorphic adenoma. (wiley.com)
- The authors carried out a retrospective cohort study of 198 patients with pleomorphic adenomas of the parotid gland. (hindawi.com)
- This yielded histology of pleomorphic adenoma with cellular myoepithelial areas containing focal necrosis. (scitechnol.com)
- Bone remodelling on imaging may suggest a benign lacrimal gland pleomorphic adenoma (LGPA) rather than a malignant process. (springermedizin.de)
- Rose GE, Wright JE (1992) Pleomorphic adenoma of the lacrimal gland. (springermedizin.de)
- Lai T, Prabhakaran VC, Malhotra R, Selva D (2009) Pleomorphic adenoma of the lacrimal gland: is there a role for biopsy? (springermedizin.de)
- Pleomorphic adenoma of the lacrimal gland in a teenager. (ac.ir)
- The common sites of pleomorphic adenoma of the minor salivary glands are the palates followed by lips and cheeks. (scopemed.org)
- Pleomorphic adenoma is the most common neoplasm in major and minor salivary glands. (bvsalud.org)
- Although pleomorphic adenomas most commonly occur in the parotid gland, it may also be encountered in the submandibular, lingual, and minor salivary glands. (parotidsurgerymd.com)
- Pleomorphic adenomas in nasal cavity are unusual and may be misdiagnosed because they have predominant myoepithelial cellularity and fewer myxoid stromata compared with those elsewhere. (elsevier.com)
- Metastasizing pleomorphic salivary adenoma' should now be considered a low-grade malignancy with a lethal potential. (semanticscholar.org)
- A pleomorphic adenoma has a small potential to transform into a malignancy over decades. (stanford.edu)
- The presence of necrosis in a pleomorphic adenoma is highly unusual. (scitechnol.com)
- MRI and PET images demonstrate a right parotid pleomorphic adenoma . (radiopaedia.org)