Adenoma: A benign epithelial tumor with a glandular organization.Adenoma, Pleomorphic: A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)Adenoma, Villous: An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.Adrenocortical Adenoma: A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.Adenoma, Liver Cell: A benign epithelial tumor of the LIVER.Adenoma, Chromophobe: A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.Growth Hormone-Secreting Pituitary Adenoma: A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Colonic Polyps: Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.ACTH-Secreting Pituitary Adenoma: A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.Adenoma, Acidophil: A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)Colonoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the colon.Adenomatous Polyps: Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)Prolactinoma: A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.Adenoma, Basophil: A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Adenomatous Polyposis Coli: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.Genes, APC: Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.Hyperparathyroidism: A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Colonic Neoplasms: Tumors or cancer of the COLON.Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Adrenal Gland Neoplasms: Tumors or cancer of the ADRENAL GLANDS.Pituitary ACTH Hypersecretion: A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Hyperaldosteronism: A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.Sphenoid Bone: An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Pituitary Gland: A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Hyperparathyroidism, Primary: A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Sella Turcica: A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND.Sigmoidoscopy: Endoscopic examination, therapy or surgery of the sigmoid flexure.Choristoma: A mass of histologically normal tissue present in an abnormal location.Rectal Neoplasms: Tumors or cancer of the RECTUM.Pituitary Apoplexy: The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.Human Growth Hormone: A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Pituitary Hormones: Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.Adenomatous Polyposis Coli Protein: A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.Parathyroidectomy: Excision of one or more of the parathyroid glands.Urethane: Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Adenoma, Bile Duct: A benign tumor of the intrahepatic bile ducts.Prolactin: A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.Colon, Descending: The segment of LARGE INTESTINE between TRANSVERSE COLON and the SIGMOID COLON.

Salivary gland tumors in Jordan: a retrospective study of 221 patients. (1/197)

AIM: To evaluate the types and clinical outcome of salivary gland tumors in Jordan. METHODS: Hospital records of 221 patients (85 women and 136 men) with salivary gland tumors, diagnosed from January 1988 to December 1997 were reviewed. The patients were analyzed according to sex, age, histopathological type and site of the tumor. Survival curves for patients with malignant tumors were constructed using Kaplan-Meier's method. RESULTS: Of the total 221 salivary gland tumors, 155 (70.2%) were parotid tumors, 42 (19%) minor salivary gland tumors, 23 (10.4%) submandibular gland tumors, and a single (0.4%) sublingual gland tumor. Most of the tumors (151, or 68.4%) were classified as benign and 70 (31.6%) were malignant. Men to women ratio was 1.6:1, and the age of the patients ranged from 2 to 81 years. The overall 5 and 10 year-survival rates for the 70 malignant tumors were 67% and 53%, respectively, for all tumor stages. Mucoepidermoid carcinoma had the best, and squamous cell carcinoma the worst 10-year survival rate. Patients treated with surgery and subsequent radiation therapy had better survival rates than those treated with surgery or radiation therapy alone. CONCLUSION: The principal site for salivary gland tumors in Jordan population was the parotid, and the pleo- morphic adenoma the most common pathological finding. Tumor characteristics and survival data for the Jordanian population are comparable to those from western countries.  (+info)

Clinically benign parotid tumours: local dissection as an alternative to superficial parotidectomy in selected cases. (2/197)

In a personal series of 162 tumours, 101 were pleomorphic adenomas 28 of which were removed by elective local extra capsular dissection and 73 by a conventional nerve dissection. There were no recurrences in either group after a mean follow-up 10.3 years, range 3-21 years for local dissection and 8.3 years, range 3-22 years for nerve dissection. Frey's syndrome did not occur after local dissection but was present in 25% of patients after a nerve dissection. Of the 162 parotid lumps, 17 proved to be a carcinoma but only one was deemed suitable for a local removal, a low grade muco epidermoid carcinoma of the accessory lobe and no recurrence has occurred after 8 years. In benign disease, local dissection gives similar results to conventional nerve dissection with less morbidity and confirms that tumour recurrence cannot be ascribed to any properties of the tumour but lies in the hands of the surgeon and depends on the care with which the tumour is removed.  (+info)

PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. (3/197)

PLAG1, a novel developmentally regulated C2H2 zinc finger gene, is consistently rearranged and overexpressed in pleomorphic adenomas of the salivary glands with 8q12 translocations. In this report, we show that PLAG1 is a nuclear protein that binds DNA in a specific manner. The consensus PLAG1 binding site is a bipartite element containing a core sequence, GRGGC, and a G-cluster, RGGK, separated by seven random nucleotides. DNA binding is mediated mainly via three of the seven zinc fingers, with fingers 6 and 7 interacting with the core and finger 3 with the G-cluster. In transient transactivation assays, PLAG1 specifically activates transcription from its consensus DNA binding site, indicating that PLAG1 is a genuine transcription factor. Potential PLAG1 binding sites were found in the promoter 3 of the human insulin-like growth factor II (IGF-II) gene. We show that PLAG1 binds IGF-II promoter 3 and stimulates its activity. Moreover, IGF-II transcripts derived from the P3 promoter are highly expressed in salivary gland adenomas overexpressing PLAG1. In contrast, they are not detectable in adenomas without abnormal PLAG1 expression nor in normal salivary gland tissue. This indicates a perfect correlation between PLAG1 and IGF-II expression. All of these results strongly suggest that IGF-II is one of the PLAG1 target genes, providing us with the first clue for understanding the role of PLAG1 in salivary gland tumor development.  (+info)

Cartilage-specific matrix protein chondromodulin-I is associated with chondroid formation in salivary pleomorphic adenomas: immunohistochemical analysis. (4/197)

Chondromodulin-I (ChM-I) is a novel cartilage-specific matrix protein. In the growth plates of the long bones, ChM-I was shown to be expressed in mature to upper hypertrophic chondrocytes, and to be deposited in the cartilage matrix. As ChM-I strongly inhibits angiogenesis, cartilage is avascular. Also, ChM-I has bifunctional activity against chondrocyte proliferation. On the other hand, pleomorphic adenomas of the salivary glands frequently have chondroid elements. To elucidate the relationship between chondroid formation and hypovascularity in salivary pleomorphic adenomas, we immunohistochemically examined the expression and localization of ChM-I in 35 cases of this tumor. ChM-I was immunolocalized to the lacunae in the chondroid elements of pleomorphic adenomas (100%). Type II collagen and aggrecan were immunolocalized throughout the matrix around lacuna cells of the chondroid element (100%, 91.7%), and ChM-I was infrequently immunolocalized to the spindle-shaped myoepithelial cells in the myxoid element (37.5%). Fibroblast growth factor-2 was strongly immunolocalized to the lacuna cells in the chondroid element (100%), among the neoplastic myoepithelial cells in the myxoid elements (96.9%), and on the basement membranes around the solid nests of neoplastic myoepithelial cells (71.4%). Although CD34 is a marker of endothelial cells, CD34 was expressed in the endothelial cells in only a few areas around the epithelial elements and in the fibrous element of pleomorphic adenomas. No signals for CD34 were observed in chondroid elements in pleomorphic adenomas (P < 0.001), but a few signals were seen in the myxoid elements (P < 0.05). These findings suggested that lacuna cells and neoplastic myoepithelial cells expressed ChM-I, and that this molecule may play an important role in hypovascularity and chondroid differentiation in pleomorphic adenoma. In conclusion, pleomorphic adenoma expressed ChM-I, which is involved in hypovascularity and chondroid formation in this type of tumor.  (+info)

Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature. (5/197)

Epithelial-myoepithelial tumors of the lung are rare neoplasms whose biological behavior and clinical course still remain to be defined. A case of epithelial-myoepithelial tumor of the lung arising from bronchial mucosa-submucosa and occurring as a polypoid lesion of the upper left bronchus in a 47-year-old man is reported. The tumor did not infiltrate the cartilaginous wall of the bronchus and showed a biphasic histological appearance with a double layering of epithelial and myoepithelial cells. Myoepithelial spindle cells with eosinophilic cytoplasm were also observed. Mitotic figures were very rare and necrosis absent. Immunohistochemical study for epithelial and muscular markers confirmed the presence of a double-cell component in the tumor, namely epithelial and myoepithelial. The patient is alive and well, with no evidence of recurrent or metastatic disease 6 months after surgery. On the basis of the present case and the six previously reported cases, we suggest using the noncommittal term pulmonary epithelial-myoepithelial tumor of unproven malignant potential (PEMTUMP) for this type of neoplasm. In addition, we first introduce p63 as a novel marker for highlighting the myoepithelial cells of the respiratory tract and speculate on the role of these cells in the development of this unusual tumor.  (+info)

High-dose-rate endobronchial brachytherapy in endobronchial metastatic malignant chondroid syringoma. (6/197)

A 65-year-old man with malignant chondroid syringoma (MCS) was found to have pulmonary metastases in the form of multiple pulmonary nodules 4 years after wide excision and adjuvant radiotherapy of a primary abdominal wall tumor. Atelectasis of the lingula due to obstructive endobronchial metastasis, resistant to combination chemotherapy, led us to perform high-dose rate (HDR) endobronchial brachytherapy for the first time in this rare tumor with a favorable response. This case emphasizes the role of HDR brachytherapy as a palliative procedure in endobronchial tumors not responding to other treatment modalities, even those considered to be radioresistant.  (+info)

Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma. (7/197)

Carcinoma ex pleomorphic adenoma (CexPA) is a carcinoma developing within a pre-existing benign pleomorphic adenoma (PA). Here we describe the identification and characterization of a series of genetic events leading to translocation, deletion/amplification, and overexpression of the HMGIC and MDM2 genes in a CexPA at an early stage of development. The tumor had a pseudodiploid stemline karyotype with a del(5)(q22-23q32-33) and a t(10;12)(p15;q14-15). In addition, there were several sidelines with double minute chromosomes (dmin) or homogeneously staining regions (hsr). Fluorescence in situ hybridization (FISH) mapping revealed that the 12q14-15 breakpoint was located centromeric to HMGIC and that the entire gene was juxtaposed to the der(10) chromosome. Detailed analysis of cells with dmin and hsr revealed that HMGIC and MDM2 were deleted from the der(10) and that the dmin and hsr were strongly positive for both genes. Southern blot analysis confirmed that both HMGIC and MDM2 were amplified and that no gross rearrangements of the genes had occurred. Immunostaining revealed that the HMGIC protein was highly overexpressed particularly in the large polymorphic cells within the carcinomatous part of the tumor. These findings suggest that amplification and overexpression of HMGIC and possibly MDM2 might be important genetic events that may contribute to malignant transformation of benign PA.  (+info)

Intraosseous pleomorphic adenoma: case report and review of the literature. (8/197)

Pleomorphic adenoma is the most common neoplasm of the salivary glands, affecting mainly the parotid gland. The preferential intraoral site of this tumor is the palate. A case of a 31-year-old woman with an intraosseous pleomorphic adenoma located in the maxilla (left paramedian region), showing an approximate evolution of one year is reported. The present intraosseous case represents a rare location, with the tumor probably originating from glandular epithelial remnants captured during embryogenesis. In a review of the literature of 142 cases of intragnathic localization (24% in the maxilla) are identified. A slight predominance of women was observed (56%), with 55% of the patients being affected during the 5th to 7th decade of life. The tumors were malignant in 94% of the cases, with special predominance of mucoepidermoid carcinoma (65%). Intraosseous pleomorphic adenomas are rare, with the present patient being the 6th case reported in the literature and the second found in the maxilla. Mean age of the 5 previously reported cases was 58.8 years.  (+info)

Aims: To assess lymphatic vascular density (LVD) and lymph vessel endothelial proliferation in a series of carcinoma ex pleomorphic adenoma (CXPA) that represents the tumour in the different carcinogenesis phases and tumour progression.. Methods: In 8 cases of early CXPA (intracapsular and minimally invasive tumours), 8 of advanced CXPA (widely invasive tumours) and 10 of pleomorphic adenoma (PA) without malignant transformation, lymphatic vessels and proliferating cells were detected using the antibodies D2-40 and Ki-67 respectively.. Results: Comparing early tumours with advanced ones, LVD was not significantly different at the tumour margin. In contrast, regarding intratumoural lymphatics, PA without malignant transformation and early CXPA contained rare, if any, lymph vessels, whereas in widely invasive carcinomas they were more numerous. However, neither intratumoural nor peritumoural LVD were increased in comparison to adjacent normal salivary gland tissue. In no case did dual ...
TY - JOUR. T1 - Pleomorphic adenoma of nasal septum. T2 - A rare case. AU - Shetty, Shama. AU - Nayak, Dipak Ranjan. AU - Jaiprakash, Padmapriya. PY - 2018/1/1. Y1 - 2018/1/1. N2 - The most common benign tumour of the major salivary glands is the pleomorphic adenoma. They are seen rarely in the minor salivary glands, usually in hard palate, soft palate and nasopharynx. Pleomorphic adenomas in nasal cavity are unusual and may be misdiagnosed because they have predominant myoepithelial cellularity and fewer myxoid stromata compared with those elsewhere. We present a case of 38-year-old male with a 2-year history of left nasal obstruction and epistaxis since 6 months. Diagnostic nasal endoscopic examination showed a soft lobulated mass in left nasal cavity attached to anterior part of the septum. Radiological examination demonstrated soft tissue mass filling left nasal cavity with an eroded septum. The biopsy from the mass was suggestive of pleomorphic adenoma and was resected endoscopically. ...
Pleomorphic adenoma is the most common salivary gland tumor on the head and neck region [1]. Metastasizing pleomorphic adenoma is a rarely detected form of clinic antity [2,3]. According to the World…
MRI and PET images demonstrate a right parotid pleomorphic adenoma. Pleomorphic adenomas are the most common salivary gland tumours. This case was donated to Radiopaedia.org by Radswiki.net
Fifty-two cases of pleomorphic adenoma of minor salivary gland origin and seventy-two cases of pleomorphic adenoma of major salivary gland origin were examined for the presence of hyaline cells (plasmacytoid cells). Hyaline cells were found in 38 percent of the minor salivary gland cases and 21 perc …
Salivary gland tumors most commonly occur in the parotid gland, accounting nearly 85% of all salivary gland tumors. But, 25% of parotid tumors are malignant (cancerous).. Pleomorphic adenoma is the most common type of benign salivary gland tumor. It is typically a slow growing tumor and occur most often in the parotid gland. It is also known as mixed tumor which describes its pleomorphic appearance as opposed to its dual origin from epithelial and myoepithelial elements.. The tumor is usually solitary and presents as a slow growing, painless and firm singular nodal mass. It is usually mobile unless found in the palate and can cause atrophy of the mandibular ramus when located in the parotid gland.. ...
This study was undertaken to evaluate and concentrate on the recurrent pleomorphic adenomas (PAs) of the parapharyngeal space. The records of 9 patients treated for recurrent PAs occupying parapharyngeal space were retrospectively reviewed. The study population comprised 6 women and 3 men with a mean age of 51 (range, 35-79 years). Before the first revision surgery, imaging studies and clinical examinations showed 1 solitary mass in 4 patients, 2 solitary masses in 3 patients, and 3 or more masses in 2 patients. After first revision surgery, 4 patients had rerecurrences with multinodular disease. Two of 4 patients underwent radiation therapy (RT), and the other 2 patients underwent second revision surgery, among whom 1 patient underwent third revision surgery, and the other one was also submitted to RT. Overall, 12 reoperations were performed, and at the end of all operations, 4 patients had rerecurrences and residual disease. In conclusion, we recommend RT to patients with multinodular disease, ...
Bruno Galletti, Francesco Freni, Francesco Gazia, Viviana Nicastro, Pietro Abita, Federico Sireci , Francesco Galletti. Parapharyngeal space lesions account for only 0.5% of head and neck tumours. A 63-year-old male presented primary pleomorphic adenomas arising de novo from minor salivary glands in the parapharyngeal space. We describe the clinical features, pathology, radiological findings and treatment of this lesion. The goal when presented with such a tumour is a correct diagnosis and the in toto excision of the tumor to avoid any recurrence.. Sireci_02.pdf. ...
Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation of parenchymatous glandular cells along with myoepithelial components, having a malignant potentiality. It is the most common type of salivary gland tumor and the most common tumor of the parotid gland. It derives its name from the architectural Pleomorphism (variable appearance) seen by light microscopy. It is also known as "Mixed tumor, salivary gland type", which describes its pleomorphic appearance as opposed to its dual origin from epithelial and myoepithelial elements. The tumor is usually solitary and presents as a slow growing, painless, firm single nodular mass. Isolated nodules are generally outgrowths of the main nodule rather than a multinodular presentation. It is usually mobile unless found in the palate and can cause atrophy of the mandibular ramus when located in the parotid gland. When found in the parotid tail, it may present as an eversion of the ear lobe. Though it is ...
Synchronous pleomorphic adenomas of the major salivary glands: a case report.: The presentation of multiple distinct tumors in major salivary glands is rare. Al
Purpose: We sought to identify genomic alterations (GAs) in salivary gland adenocarcinomas, not otherwise specified (NOS), salivary duct carcinomas (SDC), carcinoma ex pleomorphic adenoma (ca ex PA), and salivary carcinoma, NOS. Experimental design: DNA was extracted from 149 tumors. Comprehensive genomic profiling (CGP) was performed on hybridization-captured adaptor ligation-based libraries of 182 or 315 cancer-related genes plus introns from 14 or 28 genes frequently rearranged for cancer and evaluated for all classes of GAs. Results: 590 GAs were found in 157 unique genes (mean 3.9/tumor). GAs in the PI3K/AKT/mTOR pathway were more common in SDC (53.6%) than other histologies (p=0.019) Cyclin dependent kinase GAs varied amongst all histotypes: adenocarcinoma, NOS (34.6%); SDC (12.2%); ca ex PA (16.7%); carcinoma, NOS (31.2%) (p=0.043). RAS GAs were observed: adenocarcinoma, NOS (17.3%); SDC (26.8%); ca ex PA (4.2%); and carcinoma, NOS (9.4%) (p=0.054). ERBB2 GAs, including amplifications and ...
Salama AR, Sakellariou T, The Cervicofacial Advancement Flap, Oral and Maxillofacial Surgery Clinics of North America, 2014. Nadershah M, Alshadwi A, Salama A An unusual case of carcinoma ex pleomorphic adenoma of the parotid metastasizing to the mandible: case report and review of the literature. J Oral Maxillofac Surg. 2013 Feb;71(2):437-42.. McClure SA, Movahed R, Salama A, Ord RA Maxillofacial metastases: a retrospective review of one institutions 15-year experience. Oral Maxillofac Surg. 2013 Jan;71(1):178-88.. Sönmez TT, Prescher A, Salama A, Kanatas A, Zor F, Mitchell D, Zaker Shahrak A, Karaaltin MV, Knobe M, Külahci Y, Altuntas SH, Ghassemi A, Hölzle F.Comparative clinicoanatomical study of ilium and fibula as two commonly used bony donor sites for maxillofacial reconstruction.Br J Oral Maxillofac Surg. 2013 Aug 27.. Zhang T, Lubek JE, Salama A, Dyalram D, Liu X, Ord RA. Treatment of cT1N0M0 Tongue Cancer: Outcome and Prognostic Parameters. J Oral Maxillofac Surg. 2013 Sep 14. ...
METHODS: This cross-sectional study comparatively evaluated 21 cases of pleomorphic adenomas and 21 sections of regular oral mucosa from the files of an oral pathology department. The tissue sections were subjected to immunohistochemical study with a monoclonal antibody specific to CD31 protein to assess vascular density and were also stained with Sirius red to evaluate the levels of collagen. The numbers of positively-stained cells were enumerated in specific fields through morphometric study, with subsequent statistical analysis ...
title: Sinonasal pleomorphic adenoma: A single institution case series combined with a comprehensive review of literatures, doi: 10.1016/j.anl.2018.08.003, category: Article
The proto-oncogene, pleomorphic adenoma gene-like 2 (PLAGL2), is implicated in a variety of cancers including acute myeloid leukemia (AML), malignant glioma, colon cancer, and lung adenocarcinoma. There is additional evidence that PLAGL2 can function
TY - JOUR. T1 - Pleomorphic adenoma with extensive adipose content. AU - Jin, Y. T.. AU - Lian, J. D.. AU - Yan, J. J.. AU - Hwang, T. Z.. AU - Tsai, S. T.. PY - 1996/1/1. Y1 - 1996/1/1. UR - http://www.scopus.com/inward/record.url?scp=0030058826&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0030058826&partnerID=8YFLogxK. U2 - 10.1046/j.1365-2559.1996.t01-2-258289.x. DO - 10.1046/j.1365-2559.1996.t01-2-258289.x. M3 - Article. C2 - 8838128. AN - SCOPUS:0030058826. VL - 28. SP - 87. EP - 89. JO - Histopathology. JF - Histopathology. SN - 0309-0167. IS - 1. ER - ...
Question - Hi, I have an pleomorphic adenoma which has stayed the same - 6F. Find the answer to this and other Medical questions on JustAnswer
Sudhir Kumar Vujhini1, Kandukuri Mahesh Kumar2, Konduru Omkareshwar3, Sridhar Reddy4, Ganesh5. 1Associate Professor, 2Assistant Professor, 3Associate Professor, Department of Pathology, Malla Reddy Institute of Medical Sciences, Hyderabad. 4MDS PG, MNR Dental College, Sanga Reddy, Medak. 5Assistant Professor, Malla Reddy Institue Of Dental Sciences, Suraram, Hyderabad.. Abstract: Pleomorphic adenoma also called benign mixed tumor, is the most common salivary gland tumor. Most of these tumors occur in major salivary glands; Parotid gland happens to be the commonly involved one (about 90 %) and about 10 % of these occur in the minor salivary glands. The most common sites for pleomorphic adenoma of minor salivary glands are the palate, followed by the lips, the cheeks, floor of the mouth, tongue, tonsil, pharynx, the retromolar area and the nasal cavity. FNAC of intraoral swellings is rarely advised. Here, we are reporting a rare case of pleomorphic adenoma arising from the palate diagnosed on FNA ...
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Non-contrast studies -- Coronal fat-suppressed FSE T2-weighted MR image reveals a well-circumscribed hyperintense mass lesion compared with surrounding parotid tissue, within the superficial lobe, ...
Non-contrast studies -- Sagittal SE T1-weighted MR image reveals a well-circumscribed hypointense mass lesion compared with surrounding parotid tissue, within the superficial lobe.
SS noted some prominence of her right eye with mild discomfort over several months. Examination found 2 mm of proptosis on the right side and mild inferior displacement of the globe. A-scan...
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The surgical risks involved in the removal of the tumor vary with the tumor itself. A smaller, more confined tumor will be easier to remove and therefore be less likely to cause damage to the facial nerve located nearby. A tumor that extends to a wider area may carry heavier risk. According to Georgetown University Hospital, surgeons are extremely careful in working near the facial nerve and most patients heal normally and do not experience any abnormal function. ...
An Unusual Variant of a Common Palatal Salivary Gland Tumor: Case Report of a Pleomorphic Adenoma with Significant Lipomatous Metaplasia ...
Patients, Carcinoma, Saliva, Syndrome, Tissue, Adenoma, Pleomorphic Adenoma, Association, Cancer, Carcinomas, Cell, Head, Human, Lymph, Lymph Node, Metastases, Neck, Risk, Squamous Cell Carcinoma, Tongue
A 68-year-old man was referred to our oculoplastics clinic by his primary ophthalmologist with a three month history of an expanding mass in his left superotemporal orbit. He had been followed yearly with CT scans since a recurrent left lacrimal gland lesion was removed 26 years ago. The initial lesion was resected 13 years prior to that, when the patient was 29 years old. The pathology reports from both surgeries described a pleomorphic adenoma of the lacrimal gland with no malignant criteria. Neither report indicated whether the tumor had been completely resected. The last CT scan was performed almost a year before symptoms started and was read as stable with no tumor recurrence. His only current complaint was of slight episodic pain in the affected area. He denied any diplopia, vision loss, headache or other systemic symptoms. He was also treated for hypertension, hypothyroidism and dyslipidemia ...
TY - JOUR. T1 - Intrasellar salivary gland-like pleomorphic adenoma. T2 - Case report. AU - Takahashi, Satoshi. AU - Mikami, Shuji. AU - Akiyama, Takekazu. AU - Kawase, Takeshi. PY - 2011/2/1. Y1 - 2011/2/1. N2 - BACKGROUND AND IMPORTANCE: We present a rare case of a patient with intrasellar salivary gland-like pleomorphic adenoma and review the 2 previously reported cases of the clinical entity to identify their common clinical features. CLINICAL PRESENTATION: A 56-year-old Asian man visited our hospital with a chief complaint of visual disturbance caused by brain tumor that filled up the sella turcica with suprasellar extension. The patient underwent craniotomy via a left pterional approach, and the subdural, intracranial portion of the tumor was totally removed, with every artery and nerve preserved. Pathological diagnosis of the tumor was intrasellar salivary gland-like pleomorphic adenoma. Three years after the operation, the patient remains free from tumor recurrence. CONCLUSION: Tumors in ...
Discussion: Myoepithelial carcinomas (or malignant myoepitheliomas) are rare malignant salivary gland neoplasms in which the tumor cells show myoepithelial differentiation. The entity was first described by Stromeyer et al. in 1975. The tumor was included in the WHO classification of salivary gland neoplasms as a distinct clinicopathologic entity in 1991. About 60% to 70% of myoepithelial carcinomas develop in a benign mixed tumor (carcinoma ex pleomorphic adenoma), and the remainder arise de novo. Histologically, malignant myoepitheliomas are composed of one or several cell types: spindle, plasmacytoid, epithelioid, and clear cells. Frequently, one of the cell types predominates. The neoplastic cells grow either as multiple nodules or as large solid sheets separated by variable amounts of intervening hyaline or myxoid stroma. By far, the multinodular growth pattern is more prevalent. The cytologic features generally reflect the histology. The cytologic smear can show spindle, epithelioid or ...
OBJECTIVE: The aim of this study was to report the clinicopathological features of 18 epithelial tumors of the lacrimal gland treated in a single institution. STUDY DESIGN AND SETTING: Clinical data and treatment were recorded and histological features reviewed. RESULTS: Twelve tumors (66.7%) were adenoid cystic carcinoma (ACC), 5 (27.8%) pleomorphic adenoma (PA), and 1 (5.5%) carcinoma ex pleomorphic adenoma. All patients with ACC presented with advanced clinical stage, and most were treated by wide surgical resection followed by adjuvant radiotherapy. No recurrence was observed in 4 cases of ACC; however, 7 patients died from persistence of disease or by local and/or distant recurrence. All PA patients were successfully treated by surgical resection. CONCLUSIONS: Epithelial lacrimal gland tumors are mainly PA and ACC, and malignancies are more common than benign tumors. Although ACC presented typically with advanced clinical stage, 33% of the patients survived without tumor recurrence or ...
TY - JOUR. T1 - Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma from pleomorphic adenoma?. AU - Chandan, Vishal S.. AU - Wilbur, David. AU - Faquin, William C.. AU - Khurana, Kamal K.. PY - 2004/8/25. Y1 - 2004/8/25. N2 - The authors examined the role of c-kit antigen expression in cell block material obtained by fine-needle aspiration in differentiating between adenoid cystic carcinoma and pleomorphic adenoma. It was found that c-kit expression was not restricted to adenoid cystic carcinomas; instead, c-kit was expressed in pleomorphic adenomas as well. Thus, c-kit was not useful in distinguishing between these two types of lesions.. AB - The authors examined the role of c-kit antigen expression in cell block material obtained by fine-needle aspiration in differentiating between adenoid cystic carcinoma and pleomorphic adenoma. It was found that c-kit expression was not restricted to adenoid cystic carcinomas; instead, ...
Chordomas are rare tumors that are usually located in the sacrococcygeal and sphenooccipital region. Their cytologic diagnosis is rather straightforward when sampled by fine-needle aspiration (FNA) from these characteristic locations, especially when physalipherous cells are present. However, chordomas may pose difficult diagnostic challenges when encountered in unusual locations, such as the parapharyngeal region. We report the cytologic findings of a recurrent chordoma sampled through transoral FNA from the parapharyngeal space of a 66-year-old woman. As the prior history of chordoma was not available during the rapid onsite evaluation, the presence of bland epithelioid nonvacuolated cells and spindle cells intimately admixed with a fibrillary, intensely metachromatic material led to an initial diagnosis of pleomorphic adenoma. Review of the patients prior pathology specimen and of the Papanicolaou-stained smears and cellblock sections showing rare multivacuolated (physalipherous) cells led ...
Abstract Introduction: Polymorphous low grade adenocarcinoma (PLGA) is a rare salivary gland neoplasm with an indolent course. It occurs primarily in the minor salivary glands but can rarely occur in the major salivary glands. It usually occurs in the fifth to seventh decades of life with female preponderance. Case Report: A 16-year-old male presented with recurrent painless swelling in the right preauricular region and with a history of surgical intervention at the same site in the past. His histopathology report was suggestive of pleomorphic adenoma. The swelling recurred after one year of excision and a superficial parotidectomy was performed. The detailed histopathological examination was suggestive of Polymorphous low grade adenocarcinoma. In view of close margins, the patient was given adjuvant radiotherapy. Thirty-three months post-surgery, he is alive and disease-free. We describe a rare case of PLGA of the parotid gland in a teenager with its clinical characteristics, histopathological
E-cadherin is a calcium dependent cell adhesion molecule, important in cell to cell interactions in epithelial tissues. The present study examined E-cadherin expression in normal salivary glands, pleomorphic adenoma, Warthins tumor, mucoepidermoid carcinoma, acinic cell carcinoma, adenoid cystic carcinoma and adenocarcinoma of salivary glands in paraffin sections using a monoclonal antibody (5H9). This study is firstly reported E-cadherin expression in the salivary gland and tumors.,BR,In normal submandibular and parotid gland, E-cadherin staining was confined to the cell membrane of acinar and ductal cells. In excretory ducts, high columnar cells showed the strongest reaction at the basal aspect and ductal basal cells were weakly positive or negative, the basement membrane zone lacked staining. No E-cadherin reaction was observed in modified myoepithelial cells and plasmacytoid cells. In pleomorphic adenoma and mucoepidermoid carcinoma, E-cadherin was positive at the lateral cell membrane or ...
Canalicular adenoma is a type of benign salivary gland tumor that occurs most often in minor salivary glands. In addition to pleomorphic adenoma, the two are the most common tumors of the upper lip. In 95% of cases, canalicular adenoma occurs on the upper lip. The next most common location is the buccal mucosa (inner cheek). Other sites of the mouth, including the parotid gland, are rare for this disease. Canalicular adenoma is most likely to occur in older adults around 70 years of age. There is a predilection for gender with most cases being in females. Canalicular adenoma is characterized as a slow growing, painless swelling, whose diameter can be up to 2 cm. It can be normal or bluish in color. The appearance of this tumor microscopically is very distinct. There are cords of columnar or cuboidal epithelium, which have basophillic nuclei. Parallel rows of cords appear to form long canals. Frequently, there are large cystic spaces. There are no stromal alterations evident. Treatment usually ...
Classically these tumors show biphasic manifestation with admixture of varying amounts of polygonal salivary gland cells and spindle shaped myoepithelial cells. The underlying stroma could be mucoid / myxoid / cartilagenous / hyaline. Even though these tumors are not encapsulated but thickening of parotid fascia around the mass gives it an encapsulated appearance (pseudocapsule).. The main cause for this tumor is juxtapositioning of PLAG gene to the gene for beta catenin. This causes activation of catenin pathway leading on to inappropriate cell division.. ...
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Pleomorphic adenoma, also known as benign mixed tumor, is the most common tumor of salivary gland origin, accounting for about 60-70% of all salivary gland tumors (Peel and Seethala, 2007; Downer, et al., 2011; Papadogeorgakis ...
On one of the first three fridays in october, the president of the college cancels classes and declares it mountain day. Surgical treatment of pleomorphic adenoma of the parotid gland: report of cases
This post is part of a wider series about all the 6 CX disciplines that represent the CXPA Framework around which the CCXP exam is structured and that we cover in the CX Masterclass. Follow Nienke Bloem and Rosaria Cirillo to be notified as soon as a new blog post is published.. Find here the complete list of the other posts in this series:. 1. CX Strategy. 2. Customer Understanding. 3. Design, Improvement and Innovation. 4. Measurement. 5. Governance. 6. Culture (will be published on the 4th of December). Extra: CXPA exam & Becoming CCXP (will be published on the 11th of December). About this series. This post was originally posted on Wow Now and is part of the CX Framework series by Rosaria Cirillo and Nienke Bloem.. The foundations for these blogposts are written by Milou van Kerkhof following the June 2017 CX Masterclass given by Nienke Bloem and Rosaria Cirillo. Milou attended this as a newcomer in Customer Experience. These blogposts have been slightly edited and reflect only the ...
Learn about the causes, symptoms, diagnosis & treatment of Tumors of the Head and Neck from the Professional Version of the Merck Manuals.
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ဆေးပညာအချက်အလက်များကို Hello Sayarwon တွင်ရှာဖွေနိုင်ပြီး၊ Bronchial adenoma (လေပြွန်အကျိတ်ဖြစ်ခြင်း) , ၏ အဓိပ္ပါယ်ဖွင့်ဆိုချက်၊ ဖြစ်ပွားမှု အကြောင်းရင်းများနှင့် လက္ခဏာများ၊ အဖြေရှာကုသပုံများကိုလည်း ရှာဖွေနိုင်ပါသည်။
Introduction: Treatment of choice for pleomorphic adenoma of the hard palate is wide local resection of the tumor including the overlying mucosa and underlying periosteum. Most conventional methods for covering the resulting palatal wound are prosthetic devices. In this case, we examined the validity of grafting a polyglycolic acid sheet and fibrin glue over a mucosal defect of the palate with a bony surface, as a substitute for a surgical splint. Case Report: A 39-year-old male presented with a large, solid mass located on the right hard palate. Fine-needle aspiration cytology suggested pleomorphic adenoma. The patient underwent wide local resection of the lesion, and the mucosal defect was immediately covered with polyglycolic acid sheets, that were fixed with a fibrin glue spray. These sheets were tightly placed and remained in the wound, which led to complete epithelialization of the wound surface. Conclusion: Grafting the polyglycolic acid sheet with fibrin glue fixation is a useful substitute for
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether radiation therapy is more effective when given together with chemotherapy or alone after surgery in treating salivary gland tumors.. PURPOSE: This randomized phase II/III trial is studying radiation therapy with or without chemotherapy to see how well it works in treating patients with high-risk malignant salivary gland tumors that have been removed by surgery. ...
Malignant salivary gland tumours are staged using the TNM staging system: T: Tumour Tx: primary tumour cannot be assessed T0: no evidence of primary tumour T1 less than or equal to 2 cm in maximal diameter no extra-parenchymal extension T2...
Salivary Heparanase Level Is a Potential Biomarker to Diagnose and Prognose the Malignant Salivary Gland Tumor. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Pleomorphic adenoma • Pleurodont • Plica fimbriata • Polk E. Akers • Polymorphous low-grade adenocarcinoma • Polynoxylin • ... Canalicular adenoma • Canine tooth • Cantilever mechanics • Carbon dioxide laser • Caries vaccine • Carnassial • Case School of ...
Summary: Associated Cancers: colorectal and ovarian cancer; pilomatrixoma; medulloblastoma; pleomorphic adenomas; malignant ... pleomorphic adenomas, and malignant mesothelioma. While less is known about the exact mechanism of α-catenin, its presence in ... "The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the β-catenin signaling pathway". ...
Pleomorphic adenoma. References[edit]. *^ Witt, Robert L., ed. (2005). "Chapter 9 "Benign tumors, cysts, and tumor-like ... Though much less likely to occur than pleomorphic adenoma, Warthin's tumor is the second most common benign parotid tumor. ...
Pleomorphic adenoma Witt, Robert L., ed. (2005). "Chapter 9 "Benign tumors, cysts, and tumor-like conditions of the salivary ... Though much less likely to occur than pleomorphic adenoma, Warthin's tumor is the second most common benign parotid tumor. Its ...
Examples include pleomorphic adenoma and Mixed Müllerian tumor. Pleomorphism Mixed tumor "mixed tumor - definition of mixed ...
Lacrimal Gland Histology Pleomorphic adenoma of Krause's gland. ...
PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, salivary gland pleomorphic; 181030; PLAG1 Adenomatous polyposis ... TCF4 Pituitary adenoma, ACTH-secreting; 219090; AIP Pituitary adenoma, growth hormone-secreting; 102200; AIP Pituitary adenoma ... EIF2B4 Leydig cell adenoma, somatic, with precocious puberty; 176410; LHCGR Leydig cell hypoplasia with hypergonadotropic ... SCN4A Parathyroid adenoma with cystic changes; 145001; HRPT2 Parathyroid carcinoma; 608266; HRPT2 Parietal foramina 1; 168500; ...
2008). "Tenascin and fibronectin expression in carcinoma ex pleomorphic adenoma". Appl. Immunohistochem. Mol. Morphol. 16 (1): ...
The histologic differential diagnosis includes adenoid cystic carcinoma and pleomorphic adenoma. They generally have a good ...
8, 17 and vimentin in pleomorphic adenoma of the salivary glands]". Arkh. Patol. 51 (10): 28-35. PMID 2482017. Eichbaum QG, ...
The most common form of benign parotid neoplasms are pleomorphic adenomas. The most common form of malignant parotid neoplasms ...
About 40-60% of SDC arise in pleomorphic adenomas. Most, if not all, SDCs express androgen receptor by immunohistochemistry. ... "Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and ...
The benign tumors include ceruminous adenoma, ceruminous pleomorphic adenoma, and ceruminous syringocystadenoma papilliferum. ...
1998). "Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas". Oncogene. 16 (7): 865 ...
Microscopically, its histology can be confused with an adenoid cystic carcinoma and a pleomorphic adenoma. PLGAs are treated ...
"PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using ... Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is ... Voz ML, Agten NS, Van de Ven WJ, Kas K (2000). "PLAG1, the main translocation target in pleomorphic adenoma of the salivary ... in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter". Oncogene. 16 (11 ...
... and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma". Am. J. Pathol. 160 (2): 433-40. doi:10.1016/S0002-9440 ... The same mutations that lead to pituitary adenomas in mice can be found in similar cancers in humans. Its presence is ... Fedele M, Pierantoni GM, Visone R, Fusco A (September 2006). "Critical role of the HMGA2 gene in pituitary adenomas". Cell ... "Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas". Oncogene. 21 (20): 3190-8. doi: ...
Other suggestions included ameloblastoma or a benign salivary mixed tumor (also known as a pleomorphic adenoma). In the 1980s, ...
It is important that other tumors such as pleomorphic adenoma, basal cell adenoma, adenoid cystic carcinoma, and teratoma be ... "congenital pleomorphic adenoma"). A clinicopathologic, immunohistochemical and ultrastructural study of nine cases". Am J Surg ... It has previously been referred to as congenital basal cell adenoma, embryoma, or basaloid adenocarcinoma. It is an extremely ... Seifert, G.; Donath, K. (1997). "The congenital basal cell adenoma of salivary glands. Contribution to the differential ...
They included pleomorphic adenoma, myoepithelioma, myxoid neurofibroma, neurothekeoma (nerve sheath myxoma), chondroid ...
The most common of these include pleomorphic adenoma (70% of tumors, affecting predominantly females (60%)) and Warthin tumor ( ... Other malignant tumors of the parotid gland include acinic cell carcinoma, carcinoma expleomorphic adenoma, adenocarcinoma ( ...
... an example of this is the pleomorphic adenoma of the sexual reproduction salivary glands.. ...
2007). "Binding of pleomorphic adenoma gene-like 2 to the tumor necrosis factor (TNF)-alpha-responsive region of the NCF2 ... 2005). "Pleiomorphic adenoma gene-like-2, a zinc finger protein, transactivates the surfactant protein-C promoter". Am. J. ... "Entrez Gene: PLAGL2 pleiomorphic adenoma gene-like 2". Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, ...
... pleomorphic adenoma gene-like 1). PLAG1 is a transcription regulator of the type 1 receptor for pituitary adenylated cyclase- ...
Pleomorphic Adenoma Gene (PLAG) C2H2 Zinc Finger Transcription Factors 2 (ZF02) Vertebrate SMAD Family of Transcription Factors ...
Pleomorphic anaplastic neuroblastoma, Pleomorphic xanthoastrocytoma, Primary central nervous system lymphoma, Sphenoid wing ... Pituitary adenomas ("pituitary tumours") are sometimes incorrectly referred to as a brain tumours.[68][69] This is perhaps ... Most pituitary adenomas can be removed surgically, often using a minimally invasive approach through the nasal cavity and skull ... base (trans-nasal, trans-sphenoidal approach). Large pituitary adenomas require a craniotomy (opening of the skull) for their ...
Metastasizing pleomorphic adenoma is a rarely detected form of clinic antity [2,3]. According to the World… ... Pleomorphic adenoma is the most common salivary gland tumor on the head and neck region [1]. ... Pleomorphic adenoma is the most common salivary gland tumor on the head and neck region [1]. Metastasizing pleomorphic adenoma ... of the metastazing pleomorphic adenoma is related with previous pleomorphic adenoma. ...
Lymphatic vascular density and lymphangiogenesis during tumour progression of carcinoma ex pleomorphic adenoma ... Lymphatic vascular density and lymphangiogenesis during tumour progression of carcinoma ex pleomorphic adenoma ... and 10 of pleomorphic adenoma (PA) without malignant transformation, lymphatic vessels and proliferating cells were detected ... and lymph vessel endothelial proliferation in a series of carcinoma ex pleomorphic adenoma (CXPA) that represents the tumour in ...
Shetty, S., Nayak, D. R., & Jaiprakash, P. (2018). Pleomorphic adenoma of nasal septum: A rare case. BMJ Case Reports, 2018, [ ... Shetty, S, Nayak, DR & Jaiprakash, P 2018, Pleomorphic adenoma of nasal septum: A rare case, BMJ Case Reports, vol. 2018, bcr ... Pleomorphic adenoma of nasal septum : A rare case. / Shetty, Shama; Nayak, Dipak Ranjan; Jaiprakash, Padmapriya. ... title = "Pleomorphic adenoma of nasal septum: A rare case",. abstract = "The most common benign tumour of the major salivary ...
His histopathology report was suggestive of pleomorphic adenoma. The swelling recurred after one year of excision and a ... His histopathology report was suggestive of pleomorphic adenoma. The swelling recurred after one year of excision and a ...
Though it is classified as a benign tumor, pleomorphic adenomas have the capacity to grow to large proportions and may undergo ... Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation of parenchymatous ... Leonetti JP, Marzo SJ, Petruzzelli GJ, Herr B (Sep 2005). "Recurrent pleomorphic adenoma of the parotid gland". Otolaryngol ... "Histopathology of pleomorphic adenoma in the parotid gland: a prospective unselected series of 100 cases". Laryngoscope. 111 ( ...
Salivary gland Pleomorphic adenoma Di Palma, S. (Jul 2013). "Carcinoma ex pleomorphic adenoma, with particular emphasis on ... Carcinoma ex pleomorphic adenoma, abbreviated ca ex PA, is a type of cancer typically found in the parotid gland. It arises ... Carcinoma ex pleomorphic adenoma is diagnosed by examining it under the microscope with consideration of the individual history ... In approximately 75% of cases ca ex PAs arise in a pleomorphic adenoma that is apparent when the tumour is excised. In the ...
Metastasizing pleomorphic adenoma is 1 of these; the other 2 are carcinoma ex pleomorphic adenoma and true malignant mixed ... There are 3 main patterns of malignant change that occur in pleomorphic adenoma. ... Pathology of metastasizing pleomorphic adenoma. The image shows metastasizing pleomorphic adenoma of the skin on the lower ... Metastasising pleomorphic salivary adenoma: a rare case report of a massive untreated minor salivary gland pleomorphic adenoma ...
Fifty-two cases of pleomorphic adenoma of minor salivary gland origin and seventy-two cases of pleomorphic adenoma of major ... Fifty-two cases of pleomorphic adenoma of minor salivary gland origin and seventy-two cases of pleomorphic adenoma of major ... "Hyaline cells" in pleomorphic adenoma of salivary gland origin Oral Surg Oral Med Oral Pathol. 1981 Nov;52(5):506-12. doi: ...
A rare case of a benign pleomorphic adenoma is reported, arising in a parotid lymph node in a 52-year-old woman. Serial ... Takeda, Y., Suzuki, A. Benign pleomorphic adenoma arising in a parotid lymph node. Virchows Arch. A Path. Anat. and Histol. 396 ... Benign pleomorphic adenoma arising in a parotid lymph node. *Y. Takeda1. & ... A rare case of a benign pleomorphic adenoma is reported, arising in a parotid lymph node in a 52-year-old woman. Serial ...
The facial nerve provides motor innervation to the muscles of facial expression, scalp, stapedius, stylohyoideus and posterior belly of the digastric. It is sensory from the anterior 2/3 of the tongue (taste), external auditory meatus, soft palate and adjacent pharynx. It carries parasympathetic fibers which are secretomotor to the submaxillary, sublingual, lacrymal, nasal and palatine glands. It enters the substance of the parotid at the posterior border of the gland and immediately divides into a temporofacial and cervicofacial branch. Each branch subdivides into numerous nerves exiting the anterior borders of the gland to spread over the face. The marginal mandibular branch is variable, sometimes coming off the main trunk before the bifurcation. Notes ...
The facial nerve emerges at the inferior border of the pons (see brain anatomy), travels through the facial canal in the petrous portion of the temporal bone and emerges from the stylomastoid foramen. The foramen can be located by following the groove between the tympanic portion of the temporal bone and the mastoid process. The nerve is at 6:00 in relation to the ear canal. Notes ...
... pleomorphic adenoma or PA); it accounts for approximately 3-4% of all salivary gland n ... Carcinoma ex pleomorphic adenoma (CXPA) is a malignant epithelial neoplasm arising in a benign mixed tumor (i.e., ... Carcinoma ex pleomorphic adenoma (CXPA) is a malignant epithelial neoplasm arising in a benign mixed tumor (i.e., pleomorphic ... Carcinoma ex-pleomorphic adenoma of the nasal cavity: a report of two cases. J Laryngol Otol. 1995;109:677-9.PubMedCrossRef ...
A pleomorphic adenoma is a benign neoplasm that forms in the salivary gland. Although they start out benign they do have the ... While pleomorphic adenoma can occur at any age, they are most commonly diagnosed between the ages of 43 - 46. Pleomorphic ... A pleomorphic adenoma is a benign neoplasm that forms in the salivary gland. Although they start out benign they do have the ... Treatment of pleomorphic adenoma depends on the size, location and stage of the tumor. Also, if it is benign or malignant tumor ...
We report a rare case of pleomorphic adenoma arising from the lateral nasal wall. PATIENT AND METHOD: A 23year old woman ... AIM/BACKGROUND: We report a rare case of pleomorphic adenoma arising from the lateral nasal wall. PATIENT AND METHOD: A 23year ... The diagnosis, clinical behaviour and treatment of pleomorphic adenoma of the lateral nasal wall are discussed from a review of ... which are histological characteristics of pleomorphic adenoma. CONCLUSIONS: Her post-operative clinic visits were uneventful, ...
Pleomorphic adenoma. Image. Description. Pleomorphic adenoma (mixed tumor): A well circumscribed firm soft tissue enlargement ... Pleomorphic adenoma (mixed tumor): A Waters sinus radiograph of the previous patient. Note that the lesion has invaded the left ... Pleomorphic adenoma (mixed tumor): A firm well circumscribed soft tissue enlargement fills up the palatal vault. The lesion has ... Pleomorphic adenoma (mixed tumor): A microscopic image showing ducts lined by cuboidal cells, islands of epithelium, and loose ...
Pleomorphic Adenoma of the Parotid: Extracapsular Dissection Compared with Superficial Parotidectomy-A 10-Year Retrospective ... The authors carried out a retrospective cohort study of 198 patients with pleomorphic adenomas of the parotid gland. ... Extracapsular dissection may be considered the treatment of choice for pleomorphic adenomas located in the superficial portion ... rates and effectiveness of extracapsular dissection compared with superficial parotidectomy for pleomorphic adenomas of the ...
Conclusion: Metastatizing pleomorphic adenoma is a rare pathologic situation but, in case of swelling or lump appearance in ... Metastasizing pleomorphic adenomas has rarely been reported. No histologic or molecular parameters exist at the present time ... A 54-year-old woman had a superficial left parotidectomy with facial nerve preservation for pleomorphic adenoma. She developed ... patients with pleomorphic adenoma history, it should be taken in mind. ...
A review of the FNA cytologic features of this case of chordoma and of 17 consecutive cases of pleomorphic adenoma found that ... Parapharyngeal chordoma: A diagnostic challenge and potential mimic of pleomorphic adenoma on fine-needle aspiration cytology. ... A review of the literature found no previous instances in which chordomas mimicked pleomorphic adenoma on FNA. However, since ... intensely metachromatic material led to an initial diagnosis of pleomorphic adenoma. Review of the patients prior pathology ...
Treatment for Pleomorphic Adenoma. by Lee Morgan; Updated September 30, 2017 Related Articles. *Exercise Tips for Developing ... A pleomorphic adenoma is a benign tumor in the salivary glands that appears as a firm and painless mass. In rare cases these ... The most common and effective treatment for pleomorphic adenoma is a complete surgical excision of the tumor itself, according ... The WJSO reports that studies have shown a 6 to 7 percent recurrence rate for patients with benign pleomorphic adenoma. ...
Pleomorphic Adenoma Treatment in Los Angeles CA. Dr. Larian is a renowned pleomorphic adenoma treatment surgeon in Los Angeles ...
Pleomorphic adenoma of the parotid gland.. Non-contrast studies -- Sagittal SE T1-weighted MR image reveals a well- ...
Tavarez on pleomorphic adenoma hard palate: You clearly have a thyroid problem, and this needs to be discussed in context of ... Pleomorphic (Definition) We use the term pleomorphic often in pathology; it literally means "many shapes". Pleomorphic cells in ... I ve pleomorphic adenoma in parotid gland.dr performed fnac..does fnac spread tumor cells..scared.size is 1.5cm.entire gland ... Spread not likely: Pleomorphic adenoma is benign and there is minimal risk of spread with a fine needle aspirate. Removal is ...
Pleomorphic adenomas are the most common salivary gland tumours. This case was donated to Radiopaedia.org by Radswiki.net ... MRI and PET images demonstrate a right parotid pleomorphic adenoma. ... MRI and PET images demonstrate a right parotid pleomorphic adenoma. Pleomorphic adenomas are the most common salivary gland ...
Pleomorphic adenoma of the parotid gland.. Non-contrast studies -- Coronal fat-suppressed FSE T2-weighted MR image reveals a ...
Harrie R.P., Kendall C.J. (2014) Case Study 43 Pleomorphic Adenoma of Lacrimal Gland. In: Clinical Ophthalmic Echography. ...
  • In a 2003 review by Nouraei et al, 42 cases of metastasizing pleomorphic adenoma were reported in the English-language literature between 1953 and 2005. (medscape.com)
  • It should be noted, however, that the exact number of cases of metastasizing pleomorphic adenoma has been a matter of controversy among reviewing authors. (medscape.com)
  • There was associated expansion of the cavity with displacement of the nasal septum and thinning of the medial wall of the right maxillary antrum adjacent to it.The microscopic finding showed a lobular duct-like structure within a loose chondromyxoid stroma,which are histological characteristics of pleomorphic adenoma. (biomedsearch.com)
  • However there are certain histological characteristics in pleomorphic adenomas, which may raise suspicion of atypia and prompt further investigation. (scitechnol.com)
  • Both breast glands and salivary glands are ' tubulo-acinar ' exocrine glands ( meaning they are designed for secretion ), so it is not surprising that adenomas developing from those glands would have similar histological and morphological features . (breast-cancer.ca)
  • Objective: The histological diversity encountered in pleomorphic adenoma may cause diagnostic difficulty in fine needle aspiration (FNA) cytology due to limited and selective sampling. (edu.gh)
  • Conclusion: FNA cytology demonstrates well most of the histological features of pleomorphic adenoma of salivary gland and may be considered a useful tool in initial assessment of the tumour. (edu.gh)
  • The classical microscopic description was applied in 1874, observing a variety of cell types as the main characteristic of pleomorphic adenoma, not just between the different samples examined but also in different parts of the same sample 6 . (bvsalud.org)
  • Methods: This study comprised a retrospective review of data from seven patients with sinonasal pleomorphic adenoma who were treated by the authors at a tertiary medical center between January 2005 and May 2017. (elsevier.com)
  • Methods: May-Grünwald- Giemsa and Papanicolaou stained smears, and haematoxylin and eosin stained paraffin sections of 25 pleomorphic adenomas of parotid and submandibular glands were reviewed. (edu.gh)
  • As the prior history of chordoma was not available during the rapid onsite evaluation, the presence of bland epithelioid nonvacuolated cells and spindle cells intimately admixed with a fibrillary, intensely metachromatic material led to an initial diagnosis of pleomorphic adenoma. (wiley.com)