Adenoma, Oxyphilic: A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.Adenoma: A benign epithelial tumor with a glandular organization.Oxyphil Cells: Large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askenazy cells.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Adenoma, Pleomorphic: A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)Adenoma, Villous: An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.Adrenocortical Adenoma: A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.Adenoma, Liver Cell: A benign epithelial tumor of the LIVER.Adenoma, Chromophobe: A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.Growth Hormone-Secreting Pituitary Adenoma: A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Colonic Polyps: Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.ACTH-Secreting Pituitary Adenoma: A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.Adenoma, Acidophil: A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)Colonoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the colon.Adenomatous Polyps: Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)Prolactinoma: A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.Adenoma, Basophil: A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Adenomatous Polyposis Coli: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.Fluorodeoxyglucose F18: The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)AnilidesSodium Fluoride: A source of inorganic fluoride which is used topically to prevent dental caries.Positron-Emission Tomography: An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.ThyroglobulinTreatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Chief Cells, Gastric: Epithelial cells that line the basal half of the GASTRIC GLANDS. Chief cells synthesize and export an inactive enzyme PEPSINOGEN which is converted into the highly proteolytic enzyme PEPSIN in the acid environment of the STOMACH.Pepsinogens: Proenzymes secreted by chief cells, mucous neck cells, and pyloric gland cells, which are converted into pepsin in the presence of gastric acid or pepsin itself. (Dorland, 28th ed) In humans there are 2 related pepsinogen systems: PEPSINOGEN A (formerly pepsinogen I or pepsinogen) and PEPSINOGEN C (formerly pepsinogen II or progastricsin). Pepsinogen B is the name of a pepsinogen from pigs.Parietal Cells, Gastric: Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Chymosin: The predominant milk-clotting enzyme from the true stomach or abomasum of the suckling calf. It is secreted as an inactive precursor called prorennin and converted in the acid environment of the stomach to the active enzyme. EC 3.4.23.4.Pepsinogen A: This is one of 2 related pepsinogen systems in humans and is also known as pepsinogen. (The other is PEPSINOGEN C.) This includes isozymogens Pg1-Pg5 (pepsinogens 1-5, group I or products of PGA1-PGA5 genes). This is the main pepsinogen found in urine.DNA-Directed RNA Polymerases: Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Transcription Factors, TFII: The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.Transcription Factor TFIIB: An RNA POLYMERASE II specific transcription factor. It plays a role in assembly of the pol II transcriptional preinitiation complex and has been implicated as a target of gene-specific transcriptional activators.Transcription Factor TFIID: The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Adenoma, Sweat Gland: A benign neoplasm derived from epithelial cells of sweat glands. (Stedman, 25th ed)Sweat Gland NeoplasmsSyringoma: A benign tumor of the sweat glands which is usually multiple and results from malformation of sweat ducts. It is uncommon and more common in females than in males. It is most likely to appear at adolescence, and further lesions may develop during adult life. It does not appear to be hereditary. (Rook et al., Textbook of Dermatology, 4th ed, pp2407-8)Brunner Glands: The abundant submucosal mucous glands in the DUODENUM. These glands secrete BICARBONATE IONS; GLYCOPROTEINS; and PEPSINOGEN II.Neoplasms, Adnexal and Skin Appendage: Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Carbonic Anhydrases: A family of zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide. They play an important role in the transport of CARBON DIOXIDE from the tissues to the LUNG. EC 4.2.1.1.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Kidney Neoplasms: Tumors or cancers of the KIDNEY.Carbonic Anhydrase Inhibitors: A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.Carcinoma, Renal Cell: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.Angiomyolipoma: A benign tumor containing vascular, adipose, and muscle elements. It occurs most often in the kidney with smooth muscle elements (angiolipoleiomyoma) in association with tuberous sclerosis. (Dorland, 27th ed)

Expression of somatostatin receptors in oncocytic (Hurthle cell) neoplasia of the thyroid. (1/183)

Ten consecutive patients with Hurthle cell lesions of the thyroid (nodule/adenoma/carcinoma) were studied by (111)In-DTPA-D-Phe1-octreotide scintigraphy. Octreotide scintigraphy localized the primary Hurthle cell tumour in eight patients as distinct areas of increased uptake of radionuclide. Two patients with Hurthle cell carcinoma, previously thyroidectomized, had their metastases visualized by octreotide scintigraphy. Northern analyses showed expression of multiple somatostain receptor subtypes. Visualization of the Hurthle cell tumour may be due to a higher expression of somatostatin receptors in the lesions than in surrounding normal thyroid tissue. The tissue/blood (111)In concentration ratios for tumour samples from five patients showed clearly higher values than observed for normal connective tissue, muscle or lymph nodes. A relatively high uptake of (111)In was also observed in goiter tissue, which may lead to misinterpretations. The main indication for octreotide scintigraphy in patients with Hurthle cell carcinoma is suspicion of metastatic disease.  (+info)

Adrenocortical oncocytoma. (2/183)

The histopathology and ultrastructural features of an adrenocortical oncocytoma are reported. The tumour was discovered incidentally during investigation for hypertension in a 72 year old female. Oncocytic tumours of the adrenal cortex are rare, with only 20 examples described in English language reports. Most have been non-functioning and benign, like the present example. Molecular studies may help assess the significance of oncocytic change in the pathogenesis and behaviour of oncocytic neoplasms.  (+info)

Pathologic features, proliferative activity, and cyclin D1 expression in Hurthle cell neoplasms of the thyroid. (3/183)

Making a histologic distinction between Hurthle cell adenomas and carcinomas sometimes may be difficult. We analyzed a series of Hurthle cell lesions to determine whether specific histologic features and expression of Ki67 and cyclin D1 could be useful in distinguishing Hurthle cell adenomas from carcinomas. Formalin-fixed, paraffin-embedded tissues from 128 Hurthle cell neoplasms, including 59 adenomas; 55 carcinomas; and 14 tumors classified as neoplasms of uncertain malignant behavior (UMB), which had equivocal capsular invasion but no vascular invasion, were analyzed for expression of Ki67 and cyclin D1 by immunostaining. The distribution of immunoreactivity for Ki67 with antibody MIB-1 was analyzed by quantifying the percentage of positive nuclei that was expressed as the labeling index. None of the patients with adenomas or UMB tumors developed recurrent or metastatic disease after a mean follow-up of 7.8 and 7.9 years, respectively. Of the 55 patients with Hurthle cell carcinoma, 19 were associated with metastatic disease, 13 of whom died with disease. No patient with a Hurthle cell carcinoma without vascular invasion developed metastatic disease. The mean tumor size for Hurthle cell carcinomas (4.8 cm) was significantly larger than that of Hurthle cell adenomas (3.1 cm) or UMB tumors (3.7 cm). No patient with a Hurthle cell tumor smaller than 3.5 cm developed metastatic disease, even when vascular invasion was present. The Ki67 labeling index in Hurthle cell carcinomas (10.0 +/- 1.2) was 3-fold higher than in Hurthle cell adenomas (3.2 +/- 0.3). The Ki67 labeling index in the UMB group was 5.0 +/- 0.7. Cyclin D1 showed diffuse nuclear staining in 1 of the 59 (1.7%) Hurthle cell adenomas, in 10 of the 55 (18%) Hurthle cell carcinomas, and in none of the UMB tumors. In summary, analyses of the cell cycle proteins Ki67 and cyclin D1 in Hurthle cell thyroid neoplasms indicate that these markers may assist in distinguishing some Hurthle cell carcinomas from adenomas. Among the Hurthle cell carcinomas, large tumor size and vascular invasion are associated with clinically aggressive tumors. Our study also suggests that Hurthle cell neoplasms with only equivocal capsular invasion and no vascular invasion should behave in a benign manner.  (+info)

Bilateral renal oncocytoma in a Greyhound dog. (4/183)

A bilateral, locally invasive renal oncocytoma was diagnosed in a 10-year-old spayed female Greyhound dog. The diagnosis was based on positive staining of the tumor with the periodic acid-Schiff reaction prior to diastase treatment, on the immunohistochemical expression of cytoplasmic cytokeratin, and on the prominence of mitochondria in the tumor cells.  (+info)

VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation. (5/183)

To elucidate the role of somatic alterations for renal cancer etiology and prognosis, we analyzed 227 sporadic renal epithelial tumors for mutations and hypermethylations in the von Hippel-Lindau tumor suppressor gene VHL. Tumors were classified according to the recommendations of the Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC). Somatic VHL mutations were identified by PCR, single-strand conformation polymorphism analysis, and sequencing, and hypermethylations were identified by restriction enzyme digestion and Southern blotting. Frequencies of VHL alterations were established, and an association with tumor type or tumor type and tumor stage was evaluated. VHL mutations and hypermethylations were identified in 45% of clear cell renal cell carcinomas (CCRCCs) and occasionally (3 of 28) in papillary (chromophilic) renal cell carcinomas (RCCs). Lack of VHL mutations and hypermethylations in chromophobe RCCs and oncocytomas was statistically significant (P = 0.0001 and P = 0.0004, respectively). RCCs carrying VHL alterations showed, in nine cases (12%), mutations at a hot spot involving a thymine repeat (ATT.TTT) in exon 2. Tumor staging was critical to the VHL mutation/hypermethylation detection rate in CCRCCs shown by separate evaluation of patients from medical centers in Munich, Heidelberg, and Mainz. The spectrum of pT1, pT2, and pT3 CCRCCs and the VHL mutation/hypermethylation detection rate varied among these three groups. Altogether, VHL alterations were significantly associated with pT3 CCRCCs (P = 0.009). This is the first evidence of frequent somatic VHL mutations at a particular site within exon 2 and an association of VHL mutations/hypermethylations with a standard prognostic factor.  (+info)

Hurthle cell adenoma diagnosed by core needle biopsy in a male patient. (6/183)

Hurthle cell adenomas (HCAs) are a rare and potentially lethal variant of follicular tumors of the thyroid. Considerable controversy exists regarding potential risk factors, diagnosis, and treatment of HCAs. The authors report the case of a 38-year-old male patient with an 8.3 cm x 3.5 cm HCA. Diagnosis was made preoperatively from a core needle biopsy and confirmed postoperatively on frozen section. Treatment consisted of a right lobectomy.  (+info)

Immunohistochemical and ultrastructural study of clinically nonfunctioning pituitary adenomas. (7/183)

Sixty-five clinically nonfunctioning pituitary adenomas were studied by immunohistochemistry, and 12 cases were also analyzed by electron microscopy. Thirty-nine cases (60%) were immunohistochemically identified as hormone-producing adenomas. Six adenomas produced multiple hormones. Electron microscopy found seven null cell adenomas and five oncocytomas. The oncocytomas had a significantly higher incidence of hormone expression that the null cell adenomas. These results indicate that clinically nonfunctioning pituitary adenomas produce hormones, even though blood hormone levels are normal or low. Furthermore, the evidence of multihormonal production implies that two or more cell lineages including a protein hormone-producing type and a glycoprotein hormone-producing type may exist in the same nonfunctioning pituitary adenoma.  (+info)

Bronchial oncocytoma. (8/183)

CONTEXT: Oncocytomas are generally small and present slow growth. Finding of the tumor usually occurs incidentally. Their incidence is higher among male patients. Oncocytomas in mucous bronchial glands are extremely rare. CASE REPORT: A 35-year-old male who presented bronchial oncocytoma. The tumor was found after bronchoscopy that investigated an atelectasis of the upper left lobe. Histological examination with optical microscopy revealed a mature neoplasm formed by ovoid cells with thin, granular, eosinophilic cytoplasm and small nuclei similar to oncocytes. Electron microscopy showed mitochondrial hyperplasia. A three-year follow-up after thoracotomy followed by lobectomy and removal of the bronchial tumor was uneventful.  (+info)

TY - JOUR. T1 - Renal oncocytoma. T2 - A case report. AU - Akiyama, H.. AU - Shidahara, K.. AU - Nasu, Yasutomo. AU - Tsushima, T.. AU - Ohmori, H.. PY - 1995. Y1 - 1995. N2 - A case of renal oncocytoma is reported. A 79-year-old man was referred to our clinic because of a right renal mass pointed out by ultrasonography during a health check up. Computed tomography (CT), magnetic resonance imaging (MRI), angiography, and dynamic MRI suggested a right renal cell carcinoma. Rt. total nephrectomy was performed. A pathological diagnosis of renal oncocytoma was made. Renal oncocytoma is a rare benign renal tumor. We herein discuss 87 cases of renal oncocytoma which have been reported in Japan.. AB - A case of renal oncocytoma is reported. A 79-year-old man was referred to our clinic because of a right renal mass pointed out by ultrasonography during a health check up. Computed tomography (CT), magnetic resonance imaging (MRI), angiography, and dynamic MRI suggested a right renal cell carcinoma. Rt. ...
Hurthle cell tumors are an infrequent neoplasm of the thyroid gland in adults. Hurthle cell tumors represent 4. 5% to 10% of all primary thyroid epithelial neoplasms in the foreign literature. It has been known as Hurthle cell tumor since Ewing was the first to use this term in 1928. Tumor occurring in an infant was described by Symmers(1941) and Morrow(1945). The authors experienced a case of congenital Hurthle cell tumor of the thyroid gland in a 2 months old boy. He was admitted to the pediatric surgical department because of a growing mass in the neck since birth. Ultrasonogram showed a huge lobulated homogenous solid mass with medium level echogenicity in the region of the thyroid gland. Subtotal thyroidectomy of right lobe and total thyroidectomy of left lobe were done. The specimen measures 2x3x1.5 cm and 7x3x3 cm, respectively. It was an encapsulated, yellow gray firm and solid mass. The cut surface was smooth, glistening and homogenous. Microscopicully, the tumor was composed of tightly ...
... is a rare type of kidney cancer that develops in cells that are involved in the production of urine. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis). Chromophobe renal cell carcinoma usually occurs in adults between the ages of 40 and 60, although it can appear in all age groups. This type of carcinoma is associated with Birt-Hogg-Dubé syndrome, an inherited disorder caused by a mutation in the FLCN gene. The FLCN gene is involved in regulating cell growth, and a mutation in this gene can cause cells to grow out of control. This situation places affected individuals at higher risk of developing chromophobe renal cell carcinoma as well as noncancerous growths in the kidneys, lungs, and hair follicles. Common symptoms include the presence of blood in the urine, ...
... is a rare type of kidney cancer that develops in cells that are involved in the production of urine. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis). Chromophobe renal cell carcinoma usually occurs in adults between the ages of 40 and 60, although it can appear in all age groups. This type of carcinoma is associated with Birt-Hogg-Dubé syndrome, an inherited disorder caused by a mutation in the FLCN gene. The FLCN gene is involved in regulating cell growth, and a mutation in this gene can cause cells to grow out of control. This situation places affected individuals at higher risk of developing chromophobe renal cell carcinoma as well as noncancerous growths in the kidneys, lungs, and hair follicles. Common symptoms include the presence of blood in the urine, ...
TY - JOUR. T1 - Chromophobe renal cell carcinoma with sarcomatoid differentiation. AU - Lauer, Scott R.. AU - Zhou, Ming. AU - Master, Viraj A.. AU - Osunkoya, Adeboye O.. PY - 2013/4/1. Y1 - 2013/4/1. N2 - OBJECTIVE: To investigate the clinicopathologic features of chromophobe renal cell carcinoma with sarcomatoid differentiation. STUDY DESIGN: A search was made through the surgical pathology and expert consult files of two major academic institutions from 2003 to 2011 for cases of chromophobe renal cell carcinoma with sarcomatoid differentiation. RESULTS: Fourteen patients were identified. The patients included 9 males (64%) and 5 females (36%). The mean patient age was 60.4 years (range, 40-82 years). There was a left-sided predominance: left (9 patients) and right (5 patients). The mean tumor size was 14.6 cm (range, 9.5-28.0 cm), and the mean percentage sarcomatoid differentiation was 67% (range, 30-99%). All tumors exhibited moderate to extensive areas of necrosis. The nonsarcomatoid ...
We report a carcinoma that is, to the best of our knowledge, the first case of a mixed mucus-secreting and oncocytic carcinoma of the thyroid. We also describe the histochemical, immunohistochemical, and ultrastructural features of this tumor. A 59-year-old man complaining of severe bone pain and weight loss underwent clinical and radiologic investigations. The studies revealed a nodule in the left thyroid lobe that was cold by (131)I scintiscan and multiple lytic lesions of the skeleton that showed increased uptake by (99m)Tc-Sestamibi scintiscan. Left hemithyroidectomy was performed and the surgical specimen contained a well-circumscribed nodule of 3 cm in the greatest diameter. Light microscopy showed an oncocytic carcinoma with an area of glandular and papillary proliferation of mucin-producing cells. A double histochemical approach (Alcian blue-periodic acid-Schiff and Alcian blue-high-iron diamine) combined with ultrastructural investigation confirmed the presence of true mucus
Discussion: Renal oncocytoma is a benign renal neoplasm which comprises 3-7 percent of adult kidney tumors. One half to two-thirds of these lesions are found incidentally. However, they can present with hematuria, flank pain and be palpable on clinical examination. Occasionally large bilateral tumors can present as renal failure. Oncocytomas have been reported in patients with Birt-Hogg-Dube and Von-Hippel Lindau syndromes. The most common cytogenetic abnormalities include loss of chromosomes 1 and y and translocations of 11q13. In very rare cases, both kidneys show diffuse involvement with macroscopic and microscopic oncocytoma, chromophobe renal cell carcinomas, and hybrid tumors with oncocytic changes of the adjacent renal tubules epithelium. These cases have been termed renal oncocytosis. The major differential diagnosis to consider is chromophobe renal cell carcinoma. Compared to oncocytoma, chromophobe renal cell carcinoma shows nuclear hyperchromasia with nuclear membrane irregularities. ...
TY - JOUR. T1 - Hurthle cell carcinoma of the thyroid gland. T2 - Prognostic factors and results of surgical treatment. AU - McDonald, M. P.. AU - Sanders, L. E.. AU - Silverman, M. L.. AU - Chan, H. S.. AU - Buyske, J.. AU - Ditkoff, B. A.. AU - Hay, Ian D. AU - Heller, K.. PY - 1996. Y1 - 1996. N2 - Background. Hurtle cell carcinomas of the thyroid are unusual variants of well-differentiated thyroid cancers. Considered more aggressive tumors, their optimal treatment is controversial. Our institutions half century of experience, the largest series to date, includes 40 patients with Hurthle cell carcinomas of 1000 well-differentiated thyroid cancers. Methods. A retrospective study was carried out on 40 patients. Results: Seventy-two percent were female, with a median age of 53 years. Median follow-up was 9 years. With the AMES risk stratification (age, distant metastasis, capsular extent, tumor size), among the 21 high-risk patients, 10 (48%) had a recurrence or died, with median time to ...
By Montone, Kathleen T Baloch, Zubair W; LiVolsi, Virginia A Context.-Hurthle cells are eosinophilic, follicular-derived cells that are associated with a variety of nonneoplastic and neoplastic thyroid lesions. The differential diagnosis of Hurthle cell lesions is quite broad. Objective.-To review the pathologic conditions associated with Hurthle cells in the thyroid and to discuss pathology of thyroid lesions associated with oncocytic cytology. Data Sources.-A variety of thyroid nonneoplastic (autoimmune thyroiditis, multinodular goiter) and neoplastic conditions (Hurthle cell adenoma, Hurthle cell carcinoma) are associated with Hurthle cell cytology. In addition, there are several thyroid neoplasms that should be considered when one observes a Hurthle cell neoplasm in the thyroid (oncocytic variant of medullary carcinoma, several variants of papillary thyroid carcinoma). Conclusions.-Oncocytic cytology is seen in a variety of thyroid conditions that are associated with a broad differential ...
An inherited condition characterized by the development of kidney oncocytomas which are often bilateral and multifocal. This condition may be connected to Birt-Hogg-Dube syndrome.
ABSTRACT Objective: To evaluate the preoperative imaging manifestation and therapeutic effect of laparoscopic simple enucleation (SE) for localized chromophobe renal cell carcinoma (chRCC).. Materials and Methods: Clinical data of 36 patients who underwent laparoscopic SE of localized chRCC at our institute were retrospectively analyzed. All patients underwent preoperative renal protocol CT (unenhanced, arterial, venous, and delayed images). CT scan characteristics were evaluated. After intraoperative occlusion of the renal artery, the tumor was free bluntly along the pseudocapsule and enucleated totally. The patients were followed up regularly after the operation.. Results: Mean tumor diameter was 3.9±1.0 cm, 80% of tumors were homogeneous and all the tumors had complete pseudocapsule. The attenuation values were slightly lower than normal renal cortex and degree of enhancement of the tumors were significantly lower than normal renal cortex. Mean operation time was 104.3±18.2 min. Mean warm ...
Hurthle cell carcinoma is a rare, aggressive type of thyroid cancer. Treatments include surgery, radioactive iodine therapy, radiation therapy and chemotherapy.
These images are intended for educational purposes and may be freely used for such as long as the Papanicolaou Society and the Bethesda System for Reporting Thyroid Cytopathology is credited ...
The rule is do not panic when you here Hurthle cells are present in your biopsy 85% are found in benign goiter and thyroiditis nodules.. Delay surgery until you sort out if you really need it. Finding more Hurthle cells in atypical biopsy results can lead to too many surgeries without molecular marker testing on the nodule.. Call Matt for details of my evaluation of the presence of Hurthle cells seen in your biopsy.. 310-393-8860. [email protected] ...
Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology. 1991 Nov;19(5):403-10 ...
Datasets are collections of data. BioGPS has thousands of datasets available for browsing and which can be easily viewed in our interactive data chart. Learn more.. ...
B. c. d. e. Renal oncocytoma Renal adenocarcinoma Renal metanephric adenoma Transitional cell carcinoma Nephroblastoma 43. Regarding nephroblastoma a. b. c. d. e. It is also known as Wilms tumour It classically occurs in young children Nephroblastomas are purely epithelial in component It is bilateral in 20 per cent of cases It may present with failure to thrive 44. A 60-year-old male is referred to urology clinic as his GP is concerned that he may have symptoms suggestive of renal cancer a. List the common presenting symptoms of renal cell carcinoma b. Manifestations include a purpuric rash on the ankles, dorsum of the legs and buttocks, colicky abdominal pain, fleeting polyarthritis of large joints and microscopic haematuria. • Rapidly progressive glomerulonephritis (crescentic) is characterized by the presence of crescents (epithelial cell proliferation and monocyte accumulation in Bowmans space), which is usually associated with severe renal injury. g. sinusitis, nasal bridge collapse, ...
Question - What does oncocytic and hurthle cell features mean?. Ask a Doctor about diagnosis, treatment and medication for Hurthle cell cancer, Ask an Oncologist
Liz, I guess you can easily look up the stats in various places for general information e.g. here: http://www.cancer.gov/statistics/find Roughly, it looks this way - kidney cancer is one of the less frequent cancers. Figures in the US and UK are fairly similar and for 2009, in the UK Kidney cancer is the eighth most common cancer in the UK (2009), accounting for around 3% of all new cases. It is the sixth most common cancer among men in the UK (2009), accounting for more than 3% of all new cases of cancer in males. It is the ninth most common cancer among women in the UK (2009), responsible for more than 2% of all new cases of cancer in females.. In both the US and Europe, chromophobe RCC accounts for only about one in twenty cases of RCC. So, on the above figures, You could reckon that chromophobe RCC would account for around 0.15% of cancer cases in men and 0.1% of cancer cases in women. This needs to be tweaked just a little because although kidney cancer is more common in males than in ...
hurthle - MedHelps hurthle Center for Information, Symptoms, Resources, Treatments and Tools for hurthle. Find hurthle information, treatments for hurthle and hurthle symptoms.
Case Reports in Endocrinology is a peer-reviewed, Open Access journal that publishes case reports related to the endocrine system and its associated diseases.
A tumor of the thyroid gland, usually benign. Oncocytomas are mainly made up of Hurtle Cells (large cells). Occasionally they may become locally invasive and, in rare instances, metastasize.. Tags: Cancer Dictionary, O, Uncategorized. ...
[Oxyphil-cell adenoma (oncocytoma) of the caruncle (authors transl)].: By histological examination of 42 caruncle tumors we found 5 oncocytomas. All the patien
Rohan S، Tu JJ، Kao J، Mukherjee P، Campagne F، Zhou XK، Hyjek E، Alonso MA، Chen YT (Dec 2006). "Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes". Clinical Cancer Research. 12 (23): 6937-45. PMID 17145811. doi:10.1158/1078-0432.CCR-06-1268. ...
Follicular and Hurthle cell cancers are two different types of cancer, but they are often considered in the same category. They can occur at any age, but are more likely in older people.
CASE REPORT: A 28-year-old healthy male presented with a history of right upper quadrant fullness and discomfort. Hepatomegaly was expected on examination. Ultrasonographic assessment revealed a normal liver size and echo texture. However, a large cystic mass measuring 15.7×12.8 cm was found arising from the right kidney which showed no internal vascularity but turbid fluid and debris within the dependent regions of the mass. Multiphase computed tomography scan showed a large unilocular cystic mass with enhancing mural nodules. There was no lymphovascular or peri-renal invasion. The patient underwent uneventful total right renal nephrectomy. Histological examination revealed a chromophobe renal cell carcinoma of grade II ...
Speicher, Michael R.; Schoell, B.; Manoir, Stanislas du; Schröck, Evelin; Ried, Thomas; Cremer, Thomas; Störkel, S. und Kovacs, Gyula (1994): Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization. In: The American Journal of Pathology, Vol. 145, Nr. 2: S. 356-364 [PDF, 2MB] ...
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Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary ...
RCC treatment has been classically derived from clinical trials that incorporated all histologies comprising clear cell, papillary, chromophobe, and other rarer subtypes. Most recently, novel therapies (sunitinib and sorafenib) have shown significant clinical activity in advanced RCC and have changed the standard of care in this disease [1-3]. However, pivotal studies with these drugs were performed exclusively in patients with clear cell histology. Therefore, the optimal therapy for papillary and chromophobe histologies remains unknown. Overall, ChRCC is considered to portend a good prognosis and is associated with earlier-stage tumors and longer overall survival in comparison with CCRCC. There are conflicting reports on prognosis in metastatic disease, and few data on response to treatment exist. Increased VEGF-6 and c-Kit (i.e., mast/stem cell growth factor receptor; proto-oncogene c-Kit; tyrosine-protein kinase Kit; or CD117) expressions have been reported in ChRCC, but the relevance of this ...
A chromophobe is a histological structure that does not stain readily, and thus appears relatively pale under the microscope. Chromophobe cells are one of three cell types, the others being basophils and acidophils. One type of chromophobe cell is known as amphophils. Amphophils are epithelial cells found in the anterior and intermediate lobes of the pituitary. Together, these epithelial cells are responsible for producing the hormones of the anterior pituitary and releasing them into the bloodstream. Melanotrophs (also, Melanotropes) are another type of chromophobe which secrete melanocyte stimulating hormone (MSH). "Chromophobe" also refers to a type of renal cell carcinoma (distinct from "clear cell"). Chromophobe renal cancer is part of a rare, genetic disorder known as Birt-Hogg-Dubé syndrome. While renal cell carcinoma is one of the most frequently diagnosed cancers, chromophobe renal cancer only accounts for five percent of renal cancer cases. Furthermore, 30% of patients with ...
Brian I. Rini, MD, presents a case study focused on the treatment of a 64 year-old male who presented with recurrent lung nodules 9 years after a left radical nephrectomy for a clear-cell renal ...
(2009) Hirata et al. Nishinihon Journal of Urology. The association of renal angiomyolipoma and renal oncocytoma within the same kidney is rare, with only 10 cases having been reported in the literature previously. A 65-year-old woman consulted our hospital with the chief complaint of general fat...
TY - JOUR. T1 - Diagnostic utility of S100A1 expression in renal cell neoplasms. T2 - An immunohistochemical and quantitative RT-PCR study. AU - Rocca, Paolo Cossu. AU - Brunelli, Matteo. AU - Gobbo, Stefano. AU - Eccher, Albino. AU - Bragantini, Emma. AU - Mina, Maria M.. AU - Ficarra, Vincenzo. AU - Zattoni, Filiberto. AU - Zamò, Alberto. AU - Pea, Maurizio. AU - Scarpa, Aldo. AU - Chilosi, Marco. AU - Menestrina, Fabio. AU - Bonetti, Franco. AU - Eble, John N.. AU - Martignoni, Guido. PY - 2007/7/1. Y1 - 2007/7/1. N2 - S100A1 is a calcium-binding protein, which has been recently found in renal cell neoplasms. We evaluated the diagnostic utility of immunohistochemical detection of S100A1 in 164 renal cell neoplasms. Forty-one clear cell, 32 papillary, and 51 chromophobe renal cell carcinomas, and 40 oncocytomas, 164 samples of normal renal parenchyma adjacent to the tumors and 13 fetal kidneys were analyzed. The levels of S100A1 mRNA detected by quantitative RT-PCR analysis of frozen tissues ...
When is A Thyroid nodule with Hurthle cells not a neoplasm but part of a chronic thyroidits? Answer: When there are lymphocytes seen in the Hurthle cell nodule.. ...
Ruiz-Cordero R, Rao P, Li L, Qi Y, Atherton D, Peng B, Singh RR, Kim TB, Kawakami F, Routbort MJ, Alouch N, Chow CB, Tang X, Lu W, Brimo F, Matin SF, Wood CG, Tannir NM, Wistuba II, Chen K, Wang J, Medeiros LJ, Karam JA, Tamboli P, Sircar K. Hybrid oncocytic/chromophobe renal tumors are molecularly distinct from oncocytoma and chromophobe renal cell carcinoma. Mod Pathol. 2019 Jun 23. doi: 10.1038/s41379-019-0304-y. [Epub ahead of print] PubMed PMID: 31231128 ...
METASTATIC CHROMOPHOBE RCC continued from page 11 chromophobe RCC. The rest had clear cell mRCC. Overall and progression-free survival rates; time to treatment failure; overall, par-tial, and complete response rates; and stable and progressive disease were calculated. fi ed in low, intermediate, and high risk," remarked Yip. "When combined, all these factors we uncovered had an appropriate refl ection in stratifying just like wed see in clear cell RCCs." In this study, patients with IMDC fa-vorable criteria (18%) had median overall survival of 31.4 months. Those with in-termediate risk (59%) achieved an over-all survival of 27.3 months, and poor risk patients (23%) had overall survival of 4.8 months. "In the past, we didnt have a clear understanding of whether this treatment was applicable to such a rare subtype. Now… we can tell our patients in clinic that theres good grounded evidence for why we can treat them similarly to how we would patients with clear cell RCC." Evaluating Outcomes ...
was well differentiated papillary/follicular with hurthle cell involvement. If they did the pathology correct and it was papillary, it cant change, unless hurthle cells were present but indetectable at the time. I think youre safe in your diagnosis.. My thyroglobulin was under 1 for three years, I was fine, then it started to rise, and my doctors didnt tell me util I went up to 6. It went from under 1 to 2, then 4, then 6, then 9. Most insurances wont ok a PET scan until your level is over 10, but my insurance let me have one. It showed a spot in my hip bone. I had another RAI treatment in the hospital, but the uptake wasnt enough to kill the cancer there, because hurthle cell doesnt absorb radio-iodine as well as other thyroid cancers. After that my TG kept rising, and a pet scan showed the same spot in my hip. I had to have surgery to remove it. After that, my tg kept rising. At 29, my PET scan was clean, or so they thought. Six month later my TG jumped to 130. Another PET scan showed ...
The oncogenic versus suppressor roles of mitochondrial genes has been long debated. Peculiar features of mitochondrial genetics such as hetero/homoplasmy and mutation threshold are seldom taken into account in this debate. Mitochondrial DNA (mtDNA) mutations generally have been claimed to be pro-tumorigenic, but they are also hallmarks of mostly benign oncocytic tumors where they help reduce adaptation to hypoxia by destablizing hypoxia-inducible factor-1α (HIF1α). To determine the influence of a disassembling mtDNA mutation and its hetero/homoplasmy on tumorigenic and metastatic potential, we injected mice with tumor cells harboring different loads of the gene MTND1 m.3571insC. Cell cultures obtained from tumor xenografts were then analyzed to correlate energetic competence, apoptosis, α-ketoglutarate/succinate ratio and HIF1α stabilization with the mutation load. A threshold level for the anti-tumorigenic effect of MTND1 m.3571insC mutation was defined, above which tumor growth and ...
At this point, INTERNIST-I reports concerning the initial differential diagnosis that will be the focus of problem solving attention. Three lists are displayed, labeled respectively DISREGARDING, CONSIDERING, and RULEOUT. The CONSIDERING list identifies those positive findings whose differential diagnostic tasks were combined in coming to the differential diagnostic focus, which is described by the RULEOUT list. The DISREGARDING list tells what positive findings are not consistent with the differential diagnosis as formulated and are therefore being disregarded for the moment; they will, however, be attended to in due course. The keyword RULEOUT indicates what strategy INTERNIST-I is going to pursue relative to this task definition: in this case, as in any case when the differential list contains five or more alternatives, the program will try to find questions to ask which, if the response is negative, will serve to downgrade the score of one or more diagnoses on the list. While pursuing a ...
Oncocytoma, Carcinoma, Cell, Kidney, Renal Cell Carcinoma, Cytoplasm, Survival, Disease, Work, Cancers, Human, Prognosis, Adjustment, Axis, Cancer, Cells, Immunohistochemistry, Ligands, Necrosis, Patients
This paper presents the conclusions of a workshop entitled Impact of Molecular Genetics on the Classification of Renal Cell Tumours, which was held in Heidelberg in October 1996. The focus on renal cell tumours excludes any discussion of Wilms tumour and its variants, or of tumours metastatic to the kidneys. The proposed classification subdivides renal cell tumours into benign and malignant parenchymal neoplasms and, where possible, limits each subcategory to the most commonly documented genetic abnormalities. Benign tumours are subclassified into metanephric adenoma and adenofibroma, papillary renal cell adenoma, and renal oncocytoma. Malignant tumours are subclassified into common or conventional renal cell carcinoma; papillary renal cell carcinoma; chromophobe renal cell carcinoma; collecting duct carcinoma, with medullary carcinoma of the kidney; and renal cell carcinoma, unclassified. This classification is based on current genetic knowledge, correlates with recognizable histological ...
Renal oncocytosis is a rare condition in which the kidney develops numerous oncocytomas. We present a case of a 12-year-old female who presented with right-sided flank pain of one-year duration. Imaging revealed several masses in the right kidney. Tissue biopsy confirmed multiple benign oncocytomas. Due to the presence of multiple oncocytomas throughout the kidney, a radical nephrectomy was performed. Given the rarity of this condition, as well as its known association with von Hippel-Lindau disease and Birt-Hogg-Dube syndrome, genetic investigations were pursued but failed to identify any abnormalities. This patient remains well and disease free six years after surgery. A review of the literature of this rare condition was performed.
The PAX 8 gene has some association with follicular thyroid tumors. PAX8/PPARy rearrangement account for 30-40% of conventional type follicular carcinomas[14] and less than 5% of oncocytic carcinomas (aka Hurthle-Cell Neoplasms).[15] Tumors expressing the PAX8/PPARy are usually present in at a young age, small in size, present in a solid/nested growth pattern and frequently involve vascular invasion. It has been observed that PAX8/PPAR y-positive tumors rarely express RAS mutations in combination. This suggests that follicular carcinomas develop in two distinct pathways either with PAX8/PPAR y or RAS. Some whole-genome sequencing studies have shown that PAX8 also targets BRCA1 (carcinogenesis), MAPK pathways (thyroid malignancies), and Ccnb1 and Ccnb2 (cell-cycle processes). PAX8 is shown to be involved in tumor cell proliferation and differentiation, signal transduction, apoptosis, cell polarity and transport, cell motility and adhesion.[8]. Expression of PAX8 is increased in neoplastic renal ...
Materials. Carbonyl cyanide p-(trifluoro-methoxy)phenylhydrazone, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), rotenone, antimycin A, ADP, and ATP were purchased from Sigma (Milan, Italy). Dichlorodihydrofluorescein diacetate was from Molecular Probes (Invitrogen, Milan, Italy). ATP monitoring kit was from BioOrbit (Turku, Finland). Antibodies used for Western blot were mouse antibodies for complex I, II, and IV subunits, purchased in cocktails from MitoSciences (Eugene, OR); rabbit polyclonal antibody against human ND1 subunit, a kind gift from Dr. A. Lombes (Institut National de la Sante et de la Recherche Medicale, Hospital Salpetriere, Paris, France); rabbit antibody for complex III, a kind gift from Prof. C. Godinot (University Claude Bernard de Lyon, France); and mouse monoclonal antibody for porin, purchased from Molecular Probes (Invitrogen).. Cell cultures and growth conditions. Human thyroid carcinoma cell lines used are oncocytic carcinoma cell line XTC.UC1 ...
Two cell types are found in the parathyroid gland. The most abundant type is the chief (or principal) cell, which secretes parathyroid hormone. Chief cells have a prominent nucleus, and a cytoplasm that stains variably and may be light or dark depending upon its secretory activity. The second type, oxyphilic (acidophilic or eosinophilic) cells, occurs in small clumps and in fewer numbers. These cells usually have small densely staining heterochromatin and an oxyphilic cytoplasm whose perimeter is usually well defined. Oxyphilic cells usually increase in number with age but their specific function is unknown. The parathyroids are essential for life. They control blood calcium and phosphate levels. A significant decrease in blood calcium results in tetany, abnormal twitching, and muscle spasms, caused by changes in excitability at the neuromuscular junction, and death. Dietary addition of calcium and especially administration of parathyroid hormone relieves the abnormal spasms, preventing death of ...
Diana Goodwin, HT in Trenton, New Jersey asks: >>Does anyone have a copy of Hales method for colloidal iron? My pathologist has asked for it specifically, probably because it is cited in the literature for differentiation of chromophobe RCC.<< (Bryan Llewellyn has already posted a method as I send this.) The fairly recently described chromophobe variant of renal cell carcinoma (Ive seen them in study slide sets, but never one on the hoof) indeed is supposed to mark very strongly with colloidal iron. Nothing Ive read mentioned any specific technique. Apparently colloidal iron is really useful for distinguishing this uncommon variant of a common cancer. Its called chromophobe because it looks like the chromophobe adenoma of the anterior pituitary. Bob Richmond Samurai Pathologist Knoxville TN ...
The vast majority of low grade follicular cell derived thyroid carcinomas follows an indolent clinical course and is associated with very low mortality. Risk stratification using multiple clinical and pathologic characteristics has become the standard of care to guide appropriate management and avoid overtreatment. Over the past few decades, the field of thyroid pathology has witnessed several major changes that significantly impacted upon patients care. These are: 1) The reclassification of non-invasive encapsulated follicular variant of papillary thyroid carcinoma as noninvasive follicular thyroid neoplasm with papillary-like nuclear features; 2) the diagnosis of Hurthle cell carcinoma based on the presence of capsular and vascular invasion; 3) a detailed definition of poorly differentiated thyroid carcinoma, taking into consideration mitosis and necrosis; and 4) the emphasis on a detailed pathologic analysis such as the extent of vascular invasion and extrathyroidal extension ...
Renal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal cancer accounts for 1-4% of cases. RCC is not a single disease, it has several morphological subtypes. Conventional RCC (clear cell RCC) accounts for ~80% of cases, followed by papillary RCC (10-15%), chromophobe RCC (5%), and collecting duct RCC ...
Renal cancers account for more than 3% of all adult malignancies and cause more than 23,400 deaths per year in China alone. The four most common types of kidney tumours include clear cell, papillary, chromophobe and benign oncocytoma. These histological subtypes vary in their clinical course and prognosis, and different clinical strategies have been developed for their management. Some kidney tumours can be very difficult to distinguish based on the pathological assessment of morphology and immunohistochemistry. Six renal cell carcinoma microarray data sets, including 106 clear cell, 66 papillary, 42 chromophobe, 46 oncocytoma and 35 adjacent normal tissue samples, were subjected to integrative analysis. These data were combined and used as a training set for candidate gene expression signature identification. In addition, two independent cohorts of 1020 RNA-Seq samples from The Cancer Genome Atlas database and 129 qRT-PCR samples from Fudan University Shanghai Cancer Center (FUSCC) were analysed to
Telomerase is a ribonucleoprotein complex that catalyses telomeric repeat addition at the ends of chromosomes. The catalytic subunit, hTERT, acts as a key determinant for telomerase activity control; the induction of hTERT expression is required for telomerase activity. hTERT participates in cellular immortalization and is elevated in certain malignant tissues. Several tumours exhibit telomerase activity, which contributes to the infinite proliferation capacity that promotes tumour progression.. Renal cell carcinoma (RCC) represents 2% of all adult malignancies and has a high mortality rate. The WHO classifies RCC into several sub-types based on cytogenetic aberrations and morphological features; the most prevalent sub-types are clear cell (ccRCC), papillary (pRCC), and chromophobe RCC (chRCC). The aims of this thesis were to study the expression patterns of various signalling molecules, to elucidate the functional links among them, and to define the roles of these signalling molecules in the ...
A renal neoplasm is a collection of abnormal cells or tissues in the kidneys. The development of a renal neoplasm can lead to a...
A phase II study has shown that savolitinib is active in a subgroup of patients with papillary renal cell carcinoma with gene amplification or mutations in the MET pathway.
Disease Markers is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the identification of disease markers, the elucidation of their role and mechanism, as well as their application in the prognosis, diagnosis and treatment of diseases.
Oncocytic lesions of the larynx are rare. When they have occurred, their presentation has been varied; these tumors may be completely asymptomatic and discovered incidentally, but more commonly they present with voice alteration. We report a case of an oncocytic cyst in a patient who presented with an acute onset of stridor. We also discuss the clinical manifestations and management of laryngeal oncocytic cyst and its relevant pathologic features.. ...
carcinoma (chromophobe renal cell, collecting duct, medullary renal cell, mucinous tubular, rhabdoid tumor, sarcomatoid, signet ring cell, spindle cell, transitional cell, translocation cell) renal sarcoma, and wilms tumor This is an open group, members can apply to join.. ...
The articles about the possible causes of diseases of the joints of the hands, describe in detail the characteristics of the diseases and the differential diagnostic signs that distinguish one joint pathology from another
Danfeng Xu, MD, Xin Xie, MD, Wenbin Rui, MD, Chenghe Wang, MD, Juping Zhao, MD, PhD. Shanghai JiaoTang University School of Medicine, Ruijin Hospital, Department of Urology, Shanghai, China, 200025.. ABSTRACT. Introduction: Occurrence of synchronous bilateral sporadic renal masses is rare. Retroperitoneoscopical partial nephrectomy of bilateral renal masses in one session can be a technically challenging procedure due to ischemia time, paranchyma preserved and perioperative complications.. Case Description: We present a case where bilateral renal masses were synchronously excised via retroperitoneoscopy in a 53-year-old woman. There were five masses excised in all and pathology revealed chromophobe renal cell carcinoma with histologic concordance. No recurrence or metastasis was detected after 2 years of follow-up and renal function was optimal with glomerular filtration rate (GFR) 76.3 ml/min/1.73 m2, compared to the preoperative GFR of 77.5 ml/min/1.73 m2.. Conclusion: Retroperitoneoscopical ...
Utility of immunohistochemical markers in differentiating benign from malignant follicular-derived thyroid nodules : Thyroid nodules are common among adults though only a small percentage is malignant, which can histologically mimic benign nodules. Accurate diagnosis of these thyroid nodules is critical for the proper clinical management. Methods We investigated immunoexpression in 98 surgically removed benign thyroid nodules including 52 hyperplastic nodules (HN) and 46 follicular/Hurthle cell adenomas (FA),
Top 10 cancers for O60260 (Homo sapiens, UniProt): kidney, oxyphilic adenoma, stomach, gastrointestinal stromal sarcoma, frontal lobe, oligodendroglioma, NOS, brain stem, ependymoma, NOS, temporal lobe, mixed glioma, kidney, renal cell carcinoma, chromophobe type, unstated behavior, temporal lobe, astrocytoma, NOS, cortex of adrenal gland, adrenal cortical adenoma, NOS, brainstem, kidney, renal cell carcinoma, chromophobe type
Clear cell papillary renal cell carcinoma (CCPRCC) is a novel tumor entity that was recently recognized as a new distinct epithelial tumor within the
Tissue protein expression of IMP3 is emerging as a promising prognostic factor in renal cell carcinoma (RCC). The most commonly used immunohistochemical (IHC) antibody has been criticized for its low specificity. In addition, blood levels of IMP3 have not yet been analyzed in RCC. Therefore, we compared the prognostic performance of two different IMP3 IHC antibodies and assessed the prognostic relevance of IMP3 plasma levels in RCC. IMP3 levels were assessed in an overall number of 425 RCC (344× clear cell [ccRCC], 63× papillary [pRCC], 18× chromophobe [chRCC]) patients in three partly overlapping cohorts. Plasma IMP3 concentrations were determined by ELISA in 98 RCC (79× ccRCC, 15× pRCC, 4× chRCC) patients and 20 controls. IMP3 mRNA expression levels were analyzed in 73 frozen tissue samples (55× ccRCC, 12× pRCC, 6× chRCC), while protein expressions were assessed in 366 FFPE samples (294× ccRCC, 56× pRCC, 16× chRCC) using the M3626 and N-19 antibodies. IMP3 plasma and mRNA ...
OBJECTIVE To evaluate trends in urine aquaporin-1 (AQP1) and perilipin 2 (PLIN2) concentrations in sufferers with very clear cell and papillary renal cell carcinoma (RCC) this analysis determined the partnership between your urine concentration of the biomarkers and tumor size, stage and grade. mainly on tumor size (levels T1 and T2), however, not with stage T3 which shown extra-renal buy SB-742457 spread. Neither marker demonstrated a significant relationship with tumor quality. CONCLUSIONS AQP1 and PLIN2 are considerably elevated in sufferers with very clear cell and papillary renal cell carcinoma in comparison to handles. Preoperative urinary concentrations of the markers reflect tumor stage and size. Keywords: Kidney Tumor, Urine Biomarkers, Aquaporin-1, Perilipin 2 Launch Renal cell carcinoma (RCC) may be the most lethal urologic malignancy1 and buy SB-742457 theres been a reliable rise in its occurrence1C5. For instance, the overall age group adjusted renal tumor incidence has elevated ...
It has emerged that of the 38,000 Americans diagnosed with renal cell carcinoma (RCC) each year, approximately 20 percent have non-clear cell forms of the disease.
I had a possible diagnosis of kidney cancer. The suggested treatment was a partial nephrectomy. We went forward with that. It turned out the mass on my kidney was a oncocytoma - weird cell shapes/arrangements but not something that would metastasize. Here are some links about kidney cancer and partial nephrectomy. Renal Cell Cancer Update […]. Also tagged kidney cancer, nephrectomy ...
As a benign tumor, an oncocytoma does not metastasize, and also tends to be minimally invasive. Concern arises according the location of the tumor.
TY - JOUR. T1 - Oncocytic variant of mucoepidermoid carcinoma of submandibular gland. T2 - An unusual clinical and morphological entity. AU - Krishnanand, Geetha. AU - Kaur, Manpreet. AU - Rao, Ravikala V.. AU - Monappa, Vidya. PY - 2007/7/1. Y1 - 2007/7/1. N2 - In this case report we describe a rare tumor - Oncocytic variant of Mucoepidermoid carcinoma of the submandibular salivary gland with a review of the literature. Oncocytic metaplasia in salivary glands is a benign change that is associated with increasing age and also seen in a few salivary gland neoplasms, which include oncocytoma, Warthins tumor, and the rare, oncocytic carcinoma. Oncocytic differentiation in mucoepidermoid carcinoma (MEC) is uncommon. Only twelve well-documented cases of oncocytic MEC have been reported previously all of which occurred in the parotid gland. To the best of our knowledge this is the first case of oncocytic mucoepidermoid carcinoma involving the submandibular salivary gland. The recognition of this ...
Ultrasound images demonstrate a well demarcated, hypoechoic mass or a solid mass with multiple anechoic internal areas. On CT, Warthin tumors are homogeneous, enhancing soft tissue densities that contain no calcification. If calcifications are present in a benign appearing parotid mass, the diagnosis of pleomorphic adenoma should be favored. Warthin tumors are traditionally located in the posterior aspect of the tail of the parotid gland but the tumors have been known to arise from periparotid lymph nodes. Cyst formation is common and the larger the tumor the greater the chance for cystic change. On MR imaging, the tumors have low T1 and high T2 signal (similar to pleomorphic adenomas). Warthin tumors are rich in mitochondrium and therefore will accumulate Tc-99m pertechnetate on salivary scintigraphy. Unfortunately, oncocytomas and the extremely rare oncocytic carcinoma both accumulate pertechnetate as well. Imaging findings that suggest a malignant parotid mass include; irregular margins, ...
Looking for online definition of Oxyphil cells in the Medical Dictionary? Oxyphil cells explanation free. What is Oxyphil cells? Meaning of Oxyphil cells medical term. What does Oxyphil cells mean?
The ZytoLight ® SPEC VHL/CEN 3 Dual Color Probe is designed for the detection of deletions affecting the VHL gene by Fluorescence in situ Hybridization (FISH). The tumor suppressor gene VHL (von Hippel-Lindau) is located on 3p25.3 and encodes a 30 kDa protein with ubiquitin ligase E3 activity. Loss of heterozygosity (LOH) at chromosome 3p and inactivation of the VHL gene by deletion or mutation is the most frequent genetic change in sporadic as well as VHL disease-associated conventional renal cell carcinomas (RCC) whereas alterations of this region are rarely seen in papillary and chromophobe RCC. Recent studies suggest that the determination of the VHL status by FISH can significantly improve the accuracy of kidney tumor biopsy evaluation, providing prognostic information that can guide management decisions.
Brian I. Rini, MD, presents a case study focused on the treatment of a 64 year-old male who presented with recurrent lung nodules 9 years after a left radical nephrectomy for a clear-cell renal ...
OBJECTIVE To evaluate trends in urine aquaporin-1 (AQP1) and perilipin 2 (PLIN2) concentrations in sufferers with very clear cell and papillary renal cell carcinoma (RCC) this analysis determined the partnership between your urine concentration of the biomarkers and tumor size, stage and grade. mainly on tumor size (levels T1 and T2), however, not with stage … Read more OBJECTIVE To evaluate trends in urine aquaporin-1 (AQP1) and perilipin 2. Read More ...
RODERIC (Repositori dObjectes Digitals per a lEnsenyament la Recerca i la Cultura) es el repositorio institucional de la Universitat de València. Se concibe como una ventanilla única para el acceso y la difusión de la producción digital de la Universitat. RODERIC responde al compromiso de la Universitat con el movimiento de acceso abierto al conocimiento adquirido con su adhesión a la Declaración de Berlín (30 Septiembre de 2008).
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To our knowledge, few reports on the imaging of oncocytic neoplasms of the salivary glands have been published, owing to the rarity of the condition. Sakai et al1 reported an oncocytoma in the deep lobe of the parotid gland that was well-defined and solid on CT. It demonstrated decreased signal intensity on both T1- and T2-weighted MR images, attributed to the high cellularity and low free water content. According to the authors, Warthin tumor, which is a common benign parotid gland tumor in patients older than 60 years, can be differentiated from oncocytoma by its MR imaging appearance. Warthin tumors conversely demonstrate decreased signal intensity on T1-weighted images and increased signal intensity on T2-weighted images.1 Both Warthin tumors and oncocytomas show intense uptake of the nuclide on technetium-Tc99m pertechnetate radionuclide scans of the salivary glands.2. The histomorphologic findings of oncocytes include an enlarged polygonal shape with granular intensely acidophilic ...
TY - JOUR. T1 - Carbonic anhydrase IX expression in renal neoplasms. T2 - Correlation with tumor type and grade. AU - Genega, Elizabeth M.. AU - Ghebremichael, Musie. AU - Najarian, Robert. AU - Fu, Yineng. AU - Wang, Yihong. AU - Argani, Pedram. AU - Grisanzio, Chiara. AU - Signoretti, Sabina. PY - 2010/12. Y1 - 2010/12. N2 - Carbonic anhydrase IX (CAIX), a hypoxia-induced protein, is expressed in some renal tumors. We evaluated its immunohistochemical expression in 317 primary and 42 metastatic renal neoplasms (186 clear cell, 52 papillary, 35 chromophobe, 47 unclassified, and 15 Xp11.2 translocation renal cell carcinomas [RCCs]; 26 oncocytomas; 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were unknown as to whether they were primary or metastatic. We also correlated expression with tumor type and grade. Variable staining was seen in clear cell, papillary, unclassified, and Xp11.2 translocation carcinomas. One ...
Background: Renal cancer is a serious public health problem which may be under reported and registered in our setup, since the Karachi cancer registry documented only 43 cases out of 4,268 incident cancer cases over 3 year duration. Therefore we aimed to determine the clinicopathologic characteristics of adult renal tumors in our setup. Materials and Methods: The study was conducted in histopathology department, Liaquat National Hospital and included total of 68 cases of adult renal tumors over 4 years. Detailed histopathologic characteristics of tumors were analyzed. Results: Mean age of patients was 56.4 (18-84) years. Renal cell carcinoma (RCC) was the most common cell type (78%) cases; followed by transitional/urothelial carcinoma (12.5%), leiomyosarcoma (4.7%), oncocytoma (1.6%), squamous cell carcinoma (1.6%) and high grade pleomorphic undifferentiated sarcoma (1.6%). Among 50 RCC cases; 62% were conventional/clear cell RCC (CCRCC) type followed by papillary RCC(PRCC), 24%; chromophobe ...
Human Kidney Slide (Clear Cell Renal Cell Carcinoma) (5 slides/pk) Slide for IHC HTS-10405 Human Kidney Slide (Clear Cell Renal Cell Carcinoma) (5 slides/pk) Slide for IHC HTS-10405
P.215 2nd paragraph: Renal medullary carcinoma (RMC) is a very rare malignancy that accounts for less than 1% of all renal neoplasms [primary source]. RMC exhibits a highly aggressive behavior and is usually seen among young men aged between 10 and 40 years. Most patients are young African-American men [ref 2]. RMC occurs in the right kidney of more than 75% of the patients. The reported patients were associated with sickle cell hemoglobinopathy, mainly with sickle cell trait and less frequently without sickle cell disease [ref 3 ...
Can any one give me there opinion on my pathology results.. I had a fna this week and theese were the results.hypercellular specimen with macrophages and colloid.cells show hurthle cell features. feat...
Onset between Second and Sixth Decade Symptom Checker: Possible causes include Familial Papillary Thyroid Carcinoma with Papillary Renal Cell Carcinoma. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
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PITUITARY CHROMOPHOBE ADENOMAS NEUROLOGY METABOLISM THERAPY. NY 1953 first edition. Springer. Hardcover octavo. 282pp. Owner signed. VG in Good DJ, dj toned and worn. . ...
Title:Mechanisms of Acquired Resistance to Tyrosine Kinase Inhibitors in Clear - Cell Renal Cell Carcinoma (ccRCC). VOLUME: 8 ISSUE: 3. Author(s):Zofia F. Bielecka, Anna M. Czarnecka, Wojciech Solarek, Anna Kornakiewicz and Cezary Szczylik. Affiliation:Laboratory of Molecular Oncology, Department of Oncology, Military Institute of Medicine in Warsaw, Szaserów 128, 04-141 Warsaw, Poland.. Keywords:Acquired drug resistance, tyrosine kinase inhibitors, sunitinib, sorafenib, pazopanib, axitinib, tivozanib, epithelialmesenchymal transition, angiogenic switch, anti-angiogenic therapy, clear-cell renal cell carcinoma, non-genetic resistance mechanisms.. Abstract:Clear - cell renal cell carcinoma (ccRCC) is a histological subtype of renal cell carcinoma - the most prevalent adult kidney cancer. Causes of ccRCC are not completely understood and therefore number of available therapies is limited. As a consequence of tumor chemo- and radioresistance as well as restrictions in offered targeted therapies, ...
Background: Caspase 4 (CASP4) dysregulation is related to the occurrence, development, and outcome of many malignant tumors, but its role in clear cell renal cell carcinoma (ccRCC) is unclear. This study was conducted to investigate the expression level of CASP4 in tumor tissu...
X4 Pharmaceuticals, a clinical stage biotechnology company developing novel CXCR4 antagonists to improve immune cell trafficking to treat cancer and rare disease, today announced results from a pilot study of X4P-001-IO in combination with Opdivo (nivolumab) in patients with clear cell renal cell carcinoma who are non-responsive to the anti-PD-1 checkpoint inhibitor Opdivo alone.
OBJECT Oncocytic meningioma has recently been recognized as a distinct morphological variant of intracranial meningothelial neoplasms, and only a few cases have been reported in the literature. The first description of this lesion, which was based on data in six cases, revealed a potentially aggressive nature with a tendency to infiltrate the brain and to recur. However, the true behavior of, and the long-term follow-up data for, such lesions must still be outlined. METHODS The authors report on five cases of intracranial oncocytic meningiomas. On neuroimaging, the lesions showed the characteristic features of common meningiomas. All patients underwent gross-total removal of the mass together with the adjacent dura mater. No additional treatments were administered. Histologically, the tumors were composed of sheets, nests, and cords of large polygonal neoplastic cells with finely granular cytoplasm. Necrosis was absent in all cases. Mitosis was also absent or exceedingly rare, and no brain ...
Bata P, Gyebnar J, Tarnoki DL, Tarnoki AD, Kekesi D, Szendroi A, Fejer B, Szasz AM, Nyirady P, Karlinger K, Berczi V: Clear cell renal cell carcinoma and papillary renal cell carcinoma: differentiation of distinct histological types with multiphase CT, DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY 19: (5) pp. 387-392 ...
ERα36 expression in renal tumors (immunohistochemistry). (A, B) Low immunoreactivity was observed in the pericarcinous renal tissues: nephron (A) and renal tub
Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare subtype of renal cell carcinoma (RCC), that is included in the 2004 WHO classification of RCC. MTSCC is a rare neoplasm and is considered as a low-grade entity. It may be a variant of papillary RCC. This tumor occurs throughout life (age range 17-82 years) and is more frequent in females. MTSCC has a gross appearance close to papillary RCC. Microscopically, it has three histologic components: mucin, tumor cells forming tubules, and spindle cells. It is characterized by the proliferation of cuboidal and spindle cells arranged in tubular or sheet-like arrays, typically with a mucinous or myxoid background. IHC close to papillary RCC profile: CK7+, AMCAR+, CD10-. MTSCC can be a difficult diagnosis due to its morphologic heterogeneity. Several morphological variants have been described, as the mucin-poor variants, showing a predominance of tubular or spindle cell components and only minimal pale mucinous background. Focal papillations ...
a Shrew debut The Taming of the Shrew at MIT Cardiac abnormalities structural abnormalities india pharmacy. The prognosis depends on the prevalence increases to over time. Malodorous fungating tumours or oncocytomas characteristically contain a progestogen in the neurons. Derealization or depersonalization feeling detached from oneself or ones surroundings. Uss of pelvis and hip involvement will require a good opportunity for ventilation of feelings. Double usual dose mg. Low nuclear grade, strips of lter paper mm in size. Is a statistician on their edito- rial board when making speculative statements in the control which looks and tastes exactly like the stereotypical victorian buttery collector who cannot reliably report early signs. Older patients are not consistent with ovulation. Pathological changes are misinterpreted as such. Investigators should say how the ward pharmacist should be changed monthly and topical agents can occasionally be observed between the upper uterine segment. And ...
Explanation. After extensive counseling, the patient elected to proceed with staged robotic partial nephrectomies revealing a right Stage I, pT1aN0M0, G2 clear cell RCC and a left Stage III, pT3aN0M0, Type II papillary renal cell carcinoma. He is currently undergoing surveillance with imaging per the NCCN guidelines and remains without evidence of recurrence. Review of the literature demonstrates that in cases of bilateral sporadic localized synchronous renal masses, the malignant concordance rate ranges from 84-95%, with a histologic concordance rate of 93%. Benign concordance rates are much lower (ranging from 39% to 67%)1. This implies that a diagnosis of ipsilateral renal cell carcinoma is associated with contralateral RCC in the vast majority of patients, whereas ipsilateral benign pathology is associated with contralateral benign disease at a substantially lower rate. Histologic concordance is similarly high, meaning most cases of clear cell or papillary tumors ipsilaterally are concordant ...
Faculty: Christopher Przybycin, MD and Jordan Reynolds, MD, Cleveland Clinic, Cleveland, OH and Ming Zhou MD, PhD, New York University, New York, NY Diagnosis and classification of renal tumors have undergone tremendous changes in the last decade. Many new entities have been discovered. The molecular mechanisms of many tumors have been unraveled and consequently many new biomarkers and molecular tests have been increasingly used in the diagnosis and prognotification of renal tumors. Targeted therapy is available for many specific subtypes of renal tumors. All these changes will be included in the new World Health Organization Classification of Renal Neoplasia, which will be published in early 2016. It is imperative for practicing pathologists to keep abreast with the "new" tumor entities, diagnostic criteria, diagnostic markers and tests, and recent changes to the grading and staging criteria for renal cell carcinomas. Rather than a rote list of tumors with characteristics, this practically ...
8:00 AM- 5:30 PM. Credits: 6 CME and 5.75 SAMs. Course Director: Lester Thompson, MD, Woodland Hills Medical Center, Woodland Hills, CA. Course Description: There has been a remarkable increase in the knowledge about tumors, tumor development and tumor genetics in the past 15 years since the last long course devoted to head and neck pathology. Many new entities have been described, with their diagnostic criteria and ancillary supporting findings elucidated. The differential diagnostic considerations of the head and neck are broad, due in part to the wide diversity of organs, many tissue types, and the often very limited size of biopsy samples. The differences between benign, reactive lesions and lethal malignancies may be quite subtle. The primary goal of this course is to present practical, common, every-day cases across a broad spectrum of anatomic sites, discussing the development of differential diagnoses based on clinical and imaging findings, histologic features and additional techniques ...
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Is there a need for another arthritis text? The recent rapid expansion in interest and importance in this field has led to a proliferation of new publications and revisions of existing works. Dr. Katz and 28 contributors have taken a systematic and orderly approach in this book, ostensibly designed for "the busy clinician in need of a more immediate helping hand." Symptoms and signs of the more than 100 rheumatic disorders are emphasized; separate anatomical regions are dealt with in detail in separate chapters with a thorough consideration of differential diagnostic possibilities. The chapters dealing with regional signs and symptoms ...
Renal cell carcinoma (see the image below) is the most common type of kidney cancer in adults. It accounts for approximately 3% of adult malignancies and 90-95% of neoplasms arising from the kidney.
"Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomas". BMC Endocrine Disorders. 7: 8. doi:10.1186/1472- ...
The salivary gland oncocytoma is a well-circumscribed, benign neoplastic growth also called an oxyphilic adenoma. It comprises ... Thyroid oncocytomas can be benign (adenomas) or malignant (carcinomas). Grossly, oncocytic adenomas are encapsulated, solid ... The gross appearance of a minimally invasive oncocytic carcinoma is indistinguishable to that of an adenoma, while widely ... There are no reliable cytologic features which distinguish oncocytic adenomas from carcinomas and the only criterion for a ...
... may be found as a less common salivary gland neoplasm also known as Oxyphilic Adenoma. Renal oncocytoma, a kidney tumour ... Also known as: Hürthle cell (thyroid gland only) Oxyphilic cell, Askanazy cell, Apocrine metaplasia (breast gland only). ...
Oxyphilic adenoma Oncocytic adenoma Oncocytoma Hurthle cell adenoma(C73.9) Hurthle cell tumor Follicular adenoma, oxyphilic ... Black adenoma Pigmented adenoma M8373/0 Adrenal cortical adenoma, clear cell (C74.0) M8374/0 Adrenal cortical adenoma, ... oxyphilic cell (C73.9) M8300/0 Basophil adenoma (C75.1) Mucoid cell adenoma M8300/3 Basophil carcinoma (C75.1) Basophil ... NOS Pick tubular adenoma Sertoli cell adenoma Tubular androblastoma, NOS Testicular adenoma M8640/3 Sertoli cell carcinoma (C62 ...
A Hürthle cell adenoma or a minimally invasive tumor can be treated by a thyroid lobectomy, although some surgeons will perform ... Although the terms oncocyte, oxyphilic cell, and Hürthle cell are used interchangeably, Hürthle cell is used only to indicate ... Hürthle cell adenomas are most likely diagnosed much more frequently than Hürthle cell carcinomas. The female to male ratio for ... Adenoma Oncocytoma Oxyphil cell "Endocrine Pathology". Retrieved 2009-05-07. Aytug, Serhat (June 13, 2006). "Hurthle Cell ...
... adenoma, liver cell MeSH C04.557.470.035.140 --- adenoma, oxyphilic MeSH C04.557.470.035.155 --- adenoma, pleomorphic MeSH ... adenoma, acidophil MeSH C04.557.470.035.075 --- adenoma, basophil MeSH C04.557.470.035.085 --- adenoma, bile duct MeSH C04.557. ... adenoma, acidophil MeSH C04.557.465.625.650.075 --- adenoma, basophil MeSH C04.557.465.625.650.095 --- adenoma, chromophobe ... adenoma, acidophil MeSH C04.557.580.625.650.075 --- adenoma, basophil MeSH C04.557.580.625.650.095 --- adenoma, chromophobe ...
"Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomas". BMC Endocrine Disorders. 7: 8. doi:10.1186/1472- ...
2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were ... 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were ... 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were ... 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were ...
Build: Fri Jul 27 09:23:34 EDT 2018 (commit: a5c8d99). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
OXYPHILIC GRANULAR CELL ADENOMA (ONCOCYTOMA) OF THE PAROTID. LANE, STANLEY L. LANE, STANLEY L. Less ...
Adenoma, Oxyphilic. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. Endocrine System Diseases. ...
What is Adenoma of the adrenal gland? Meaning of Adenoma of the adrenal gland medical term. What does Adenoma of the adrenal ... Looking for online definition of Adenoma of the adrenal gland in the Medical Dictionary? Adenoma of the adrenal gland ... adenoma, oxyphilic,. n See oncocytoma.. adenoma. a benign epithelial tumor in which the cells form recognizable glandular ... nonsecreting adenoma (nonsecretory adenoma) endocrine-inactive adenoma.. null-cell adenoma a pituitary adenoma whose cells give ...
... nipple adenoma explanation free. What is nipple adenoma? Meaning of nipple adenoma medical term. What does nipple adenoma mean? ... Looking for online definition of nipple adenoma in the Medical Dictionary? ... adenoma, oxyphilic,. n See oncocytoma.. adenoma. a benign epithelial tumor in which the cells form recognizable glandular ... nonsecreting adenoma (nonsecretory adenoma) endocrine-inactive adenoma.. null-cell adenoma a pituitary adenoma whose cells give ...
Adenoma, Oxyphilic / pathology * Adult * Aged * Carcinoma, Renal Cell / genetics * Carcinoma, Renal Cell / pathology* ...
Adenoma, Oxyphilic / genetics* * Adenoma, Oxyphilic / pathology * Adolescent * Adult * Carcinoma, Papillary / genetics* * ...
The histological diagnosis was that of oxyphilic adenoma with an oncocytic appearance compatible with oncocytoma. In view of ...
Oxyphilic Adenoma (Oncocytoma) 06/01/2012 - "Three microRNAs and 12 mRNA genes had a ≥98% coding region contained within CNV ...
41.3%), chromophobic adenomas (. , 4.3%), and oxyphilic adenoma (. , 2.2%). Disturbed circulation was responsible for the ... Seventeen adenomas exhibited all three features; 4 adenomas contained necrotic foci and areas of hemorrhage, and 1 adenoma ... 3 basophilic-oxyphilic, 1 oxyphilic-chromophobic) and the rest oxyphilic. ... Light microscopy was used to verify diagnosis of pituitary adenomas (basophilic, oxyphilic, chromophobic and mixed), carcinoid ...
DV, Mykiskova, I, Kutzner, H. "Hidradenoma papilliferum with oxyphilic metaplasia. A clinicopathological study of 18 cases, ... Scurry, J, van der Putte, SC, Pyman, J, Chetty, N, Szabo, R. " Mammary-like gland adenoma of the vulva: review of 46 cases". ... Hidradenoma Papilliferum (Papillary Hidradenoma, Mammary-like Gland Adenoma) ( 216.9=Benign Skin Neoplasm, ICD 10 - other ... The histologic differential diagnosis includes syringocystadenoma papilliferum and tubular apocrine adenoma. In general, the ...
The salivary gland oncocytoma is a well-circumscribed, benign neoplastic growth also called an oxyphilic adenoma. It comprises ... Thyroid oncocytomas can be benign (adenomas) or malignant (carcinomas). Grossly, oncocytic adenomas are encapsulated, solid ... The gross appearance of a minimally invasive oncocytic carcinoma is indistinguishable to that of an adenoma, while widely ... There are no reliable cytologic features which distinguish oncocytic adenomas from carcinomas and the only criterion for a ...
intraoperative complications, nephrectomy, oxyphilic adenoma, postoperative complications, renal oncocytoma. UCL classification ...
Oncocytic (Hürthle cell, oxyphilic cell, askanazi cell) adenoma: transcapsular and/or vascular invasion absent.. ... Oncocytic adenomas are treated with a simple lobectomy or nodulectomy, which is curative but should not be enucleated, as an ... Neuro-Endocrine/Endocrine system: Thyroid::Oncocytoic tumor (Hürthle cells adenoma). WHO/OMS Classification. Neuro-Endocrine/ ... The mean age at diagnosis was 43 years for adenomas and 52 for oncocytic carcinomas in a recent series. There is a female ...
... may be found as a less common salivary gland neoplasm also known as Oxyphilic Adenoma. Renal oncocytoma, a kidney tumour ... Also known as: Hürthle cell (thyroid gland only) Oxyphilic cell, Askanazy cell, Apocrine metaplasia (breast gland only). ...
12 Synonyms for this tumor include oncocytic adenoma, oxyphilic granular-cell adenoma, and oxyphilic adenoma. ... Bilateral and multifocal parotid tumors on CT also render pleomorphic adenomas and basal cell adenomas less likely differential ... a feature seen mainly with pleomorphic adenomas but also in Warthin tumors and basal cell adenomas.2,17,32,33 Three of our ... basal cell adenomas, and, to a lesser degree, pleomorphic adenomas. However, when taken together, the diagnosis of a benign ...
Oxyphilic Adenoma * Genetic Techniques 2000 BCG-induced urinary cytokines inhibit microvascular endothelial cell proliferation ...
Oxyphilic Adenoma Medicine & Life Sciences * Clear-cell metastatic renal cell carcinoma Medicine & Life Sciences ...
Called also oxyphilic adenoma of thyroid gland. ... Hürthle cell adenoma - a follicular adenoma of the thyroid in ... See also: Hürthle cell adenoma. Synonym(s): Hürthle cell carcinoma. Hürthle, Karl W., German histologist, 1860-1945. Hürthle ... Such tumors are usually benign (Hürthle cell adenoma) but on occasion may be locally invasive or may rarely metastasize ( ... large oxyphilic, eosinophilic cells found in the thyroid gland. They are metabolically altered follicular cells which ...
Oxyphilic parathyroid adenoma and lithium therapy. Lancet. 1998 Sep 26; 352 (9133): 1070. ...
J. Müller-Höcker, "Immunoreactivity of p53, Ki-67, and Bcl-2 in oncocytic adenomas and carcinomas of the thyroid gland," Human ... is associated with cyclin D3 overexpression in the oxyphilic (Hurthle cell) variant of follicular thyroid carcinoma," Journal ... "Differential reactivity for galectin-3 in Hürthle cell adenomas and carcinomas," Endocrine Pathology, vol. 12, no. 3, pp. 275- ... Immunohistochemistry and Tumor Dimensions Are Useful in Distinguishing Follicular Oncocytic Carcinomas from Oncocytic Adenomas ...
TY - JOUR. T1 - Multiphasic enhancement patterns of small renal masses (≤4 cm) on preoperative computed tomography. T2 - Utility for distinguishing subtypes of renal cell carcinoma, angiomyolipoma, and oncocytoma. AU - Pierorazio, Phillip Martin. AU - Hyams, Elias S.. AU - Tsai, Salina. AU - Feng, Zhaoyong. AU - Trock, Bruce. AU - Mullins, Jeffrey K.. AU - Johnson, Pamela. AU - Fishman, Elliot K. AU - Allaf, Mohamad E. PY - 2013/6. Y1 - 2013/6. N2 - Objective: To analyze the enhancement patterns of small renal masses (SRMs) during 4-phase computed tomography (CT) imaging to predict histology. Methods: One-hundred consecutive patients with SRMs and 4-phase preoperative CT imaging, who underwent extirpative surgery with a pathologic diagnosis of renal cell carcinoma (RCC), angiomyolipoma (AML), or oncocytoma, were identified from a single institution. An expert radiologist, blinded to histologic results, retrospectively recorded tumor size, RENAL (radius, exophytic/endophytic properties of the ...
A 45-year-old woman was referred to our Nuclear Department with a palpable neck nodule suspicious for parathyroid adenoma. She ... This case report presents the significance and practicality of 99mTc-tetrofosmin for the diagnosis of parathyroid adenomas with ... of reverse 99m Tc-tetrofosmin scintigraphy as a useful and safe examination technique for the diagnosis of parathyroid adenomas ... Tc-sestamibi is the most frequently used radionuclide agent for the detection of parathyroid adenomas in the clinical setting. ...
  • Three cases of MTC, Hürthle cell adenoma and papillary thyroid cancer are reported with preoperative scintigraphy, T/B ratios and Northern analyses of the surgical biopsies. (gu.se)
  • Serum levels of parathyroid hormone (PTH), alkaline phosphatase (ALP), calcium, creatinine, and vitamin D and the glomerular filtration rate were compared with the histologic properties and expression of PTH and chromogranin A in excised parathyroid adenomas from patients with primary hyperparathyroidism (pHPT). (lu.se)