A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
A benign epithelial tumor with a glandular organization.
Large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askenazy cells.
Tumors or cancer of the THYROID GLAND.
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.
A benign epithelial tumor of the LIVER.
A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.
A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.
A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.
A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)
A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.
A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)
Tumors or cancers of the ADRENAL CORTEX.
A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
A source of inorganic fluoride which is used topically to prevent dental caries.
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Autosomal dominant neoplastic syndrome characterised by genodermatosis, lung cysts, spontaneous and recurrent PNEUMOTHORAX; and RENAL CANCER. It is associated with mutations in the folliculin protein gene (FLCN protein).
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
An enzyme that catalyzes the phosphorylation of AMP to ADP in the presence of ATP or inorganic triphosphate. EC 2.7.4.3.
Databases devoted to knowledge about specific genes and gene products.
Macromolecular complexes formed from the association of defined protein subunits.
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Epithelial cells that line the basal half of the GASTRIC GLANDS. Chief cells synthesize and export an inactive enzyme PEPSINOGEN which is converted into the highly proteolytic enzyme PEPSIN in the acid environment of the STOMACH.
Proenzymes secreted by chief cells, mucous neck cells, and pyloric gland cells, which are converted into pepsin in the presence of gastric acid or pepsin itself. (Dorland, 28th ed) In humans there are 2 related pepsinogen systems: PEPSINOGEN A (formerly pepsinogen I or pepsinogen) and PEPSINOGEN C (formerly pepsinogen II or progastricsin). Pepsinogen B is the name of a pepsinogen from pigs.
Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The predominant milk-clotting enzyme from the true stomach or abomasum of the suckling calf. It is secreted as an inactive precursor called prorennin and converted in the acid environment of the stomach to the active enzyme. EC 3.4.23.4.
This is one of 2 related pepsinogen systems in humans and is also known as pepsinogen. (The other is PEPSINOGEN C.) This includes isozymogens Pg1-Pg5 (pepsinogens 1-5, group I or products of PGA1-PGA5 genes). This is the main pepsinogen found in urine.
Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.
An RNA POLYMERASE II specific transcription factor. It plays a role in assembly of the pol II transcriptional preinitiation complex and has been implicated as a target of gene-specific transcriptional activators.
The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
A benign neoplasm derived from epithelial cells of sweat glands. (Stedman, 25th ed)
A benign tumor of the sweat glands which is usually multiple and results from malformation of sweat ducts. It is uncommon and more common in females than in males. It is most likely to appear at adolescence, and further lesions may develop during adult life. It does not appear to be hereditary. (Rook et al., Textbook of Dermatology, 4th ed, pp2407-8)
The abundant submucosal mucous glands in the DUODENUM. These glands secrete BICARBONATE IONS; GLYCOPROTEINS; and PEPSINOGEN II.
Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.
Tumors or cancer of the DUODENUM.

Expression of somatostatin receptors in oncocytic (Hurthle cell) neoplasia of the thyroid. (1/183)

Ten consecutive patients with Hurthle cell lesions of the thyroid (nodule/adenoma/carcinoma) were studied by (111)In-DTPA-D-Phe1-octreotide scintigraphy. Octreotide scintigraphy localized the primary Hurthle cell tumour in eight patients as distinct areas of increased uptake of radionuclide. Two patients with Hurthle cell carcinoma, previously thyroidectomized, had their metastases visualized by octreotide scintigraphy. Northern analyses showed expression of multiple somatostain receptor subtypes. Visualization of the Hurthle cell tumour may be due to a higher expression of somatostatin receptors in the lesions than in surrounding normal thyroid tissue. The tissue/blood (111)In concentration ratios for tumour samples from five patients showed clearly higher values than observed for normal connective tissue, muscle or lymph nodes. A relatively high uptake of (111)In was also observed in goiter tissue, which may lead to misinterpretations. The main indication for octreotide scintigraphy in patients with Hurthle cell carcinoma is suspicion of metastatic disease.  (+info)

Adrenocortical oncocytoma. (2/183)

The histopathology and ultrastructural features of an adrenocortical oncocytoma are reported. The tumour was discovered incidentally during investigation for hypertension in a 72 year old female. Oncocytic tumours of the adrenal cortex are rare, with only 20 examples described in English language reports. Most have been non-functioning and benign, like the present example. Molecular studies may help assess the significance of oncocytic change in the pathogenesis and behaviour of oncocytic neoplasms.  (+info)

Pathologic features, proliferative activity, and cyclin D1 expression in Hurthle cell neoplasms of the thyroid. (3/183)

Making a histologic distinction between Hurthle cell adenomas and carcinomas sometimes may be difficult. We analyzed a series of Hurthle cell lesions to determine whether specific histologic features and expression of Ki67 and cyclin D1 could be useful in distinguishing Hurthle cell adenomas from carcinomas. Formalin-fixed, paraffin-embedded tissues from 128 Hurthle cell neoplasms, including 59 adenomas; 55 carcinomas; and 14 tumors classified as neoplasms of uncertain malignant behavior (UMB), which had equivocal capsular invasion but no vascular invasion, were analyzed for expression of Ki67 and cyclin D1 by immunostaining. The distribution of immunoreactivity for Ki67 with antibody MIB-1 was analyzed by quantifying the percentage of positive nuclei that was expressed as the labeling index. None of the patients with adenomas or UMB tumors developed recurrent or metastatic disease after a mean follow-up of 7.8 and 7.9 years, respectively. Of the 55 patients with Hurthle cell carcinoma, 19 were associated with metastatic disease, 13 of whom died with disease. No patient with a Hurthle cell carcinoma without vascular invasion developed metastatic disease. The mean tumor size for Hurthle cell carcinomas (4.8 cm) was significantly larger than that of Hurthle cell adenomas (3.1 cm) or UMB tumors (3.7 cm). No patient with a Hurthle cell tumor smaller than 3.5 cm developed metastatic disease, even when vascular invasion was present. The Ki67 labeling index in Hurthle cell carcinomas (10.0 +/- 1.2) was 3-fold higher than in Hurthle cell adenomas (3.2 +/- 0.3). The Ki67 labeling index in the UMB group was 5.0 +/- 0.7. Cyclin D1 showed diffuse nuclear staining in 1 of the 59 (1.7%) Hurthle cell adenomas, in 10 of the 55 (18%) Hurthle cell carcinomas, and in none of the UMB tumors. In summary, analyses of the cell cycle proteins Ki67 and cyclin D1 in Hurthle cell thyroid neoplasms indicate that these markers may assist in distinguishing some Hurthle cell carcinomas from adenomas. Among the Hurthle cell carcinomas, large tumor size and vascular invasion are associated with clinically aggressive tumors. Our study also suggests that Hurthle cell neoplasms with only equivocal capsular invasion and no vascular invasion should behave in a benign manner.  (+info)

Bilateral renal oncocytoma in a Greyhound dog. (4/183)

A bilateral, locally invasive renal oncocytoma was diagnosed in a 10-year-old spayed female Greyhound dog. The diagnosis was based on positive staining of the tumor with the periodic acid-Schiff reaction prior to diastase treatment, on the immunohistochemical expression of cytoplasmic cytokeratin, and on the prominence of mitochondria in the tumor cells.  (+info)

VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation. (5/183)

To elucidate the role of somatic alterations for renal cancer etiology and prognosis, we analyzed 227 sporadic renal epithelial tumors for mutations and hypermethylations in the von Hippel-Lindau tumor suppressor gene VHL. Tumors were classified according to the recommendations of the Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC). Somatic VHL mutations were identified by PCR, single-strand conformation polymorphism analysis, and sequencing, and hypermethylations were identified by restriction enzyme digestion and Southern blotting. Frequencies of VHL alterations were established, and an association with tumor type or tumor type and tumor stage was evaluated. VHL mutations and hypermethylations were identified in 45% of clear cell renal cell carcinomas (CCRCCs) and occasionally (3 of 28) in papillary (chromophilic) renal cell carcinomas (RCCs). Lack of VHL mutations and hypermethylations in chromophobe RCCs and oncocytomas was statistically significant (P = 0.0001 and P = 0.0004, respectively). RCCs carrying VHL alterations showed, in nine cases (12%), mutations at a hot spot involving a thymine repeat (ATT.TTT) in exon 2. Tumor staging was critical to the VHL mutation/hypermethylation detection rate in CCRCCs shown by separate evaluation of patients from medical centers in Munich, Heidelberg, and Mainz. The spectrum of pT1, pT2, and pT3 CCRCCs and the VHL mutation/hypermethylation detection rate varied among these three groups. Altogether, VHL alterations were significantly associated with pT3 CCRCCs (P = 0.009). This is the first evidence of frequent somatic VHL mutations at a particular site within exon 2 and an association of VHL mutations/hypermethylations with a standard prognostic factor.  (+info)

Hurthle cell adenoma diagnosed by core needle biopsy in a male patient. (6/183)

Hurthle cell adenomas (HCAs) are a rare and potentially lethal variant of follicular tumors of the thyroid. Considerable controversy exists regarding potential risk factors, diagnosis, and treatment of HCAs. The authors report the case of a 38-year-old male patient with an 8.3 cm x 3.5 cm HCA. Diagnosis was made preoperatively from a core needle biopsy and confirmed postoperatively on frozen section. Treatment consisted of a right lobectomy.  (+info)

Immunohistochemical and ultrastructural study of clinically nonfunctioning pituitary adenomas. (7/183)

Sixty-five clinically nonfunctioning pituitary adenomas were studied by immunohistochemistry, and 12 cases were also analyzed by electron microscopy. Thirty-nine cases (60%) were immunohistochemically identified as hormone-producing adenomas. Six adenomas produced multiple hormones. Electron microscopy found seven null cell adenomas and five oncocytomas. The oncocytomas had a significantly higher incidence of hormone expression that the null cell adenomas. These results indicate that clinically nonfunctioning pituitary adenomas produce hormones, even though blood hormone levels are normal or low. Furthermore, the evidence of multihormonal production implies that two or more cell lineages including a protein hormone-producing type and a glycoprotein hormone-producing type may exist in the same nonfunctioning pituitary adenoma.  (+info)

Bronchial oncocytoma. (8/183)

CONTEXT: Oncocytomas are generally small and present slow growth. Finding of the tumor usually occurs incidentally. Their incidence is higher among male patients. Oncocytomas in mucous bronchial glands are extremely rare. CASE REPORT: A 35-year-old male who presented bronchial oncocytoma. The tumor was found after bronchoscopy that investigated an atelectasis of the upper left lobe. Histological examination with optical microscopy revealed a mature neoplasm formed by ovoid cells with thin, granular, eosinophilic cytoplasm and small nuclei similar to oncocytes. Electron microscopy showed mitochondrial hyperplasia. A three-year follow-up after thoracotomy followed by lobectomy and removal of the bronchial tumor was uneventful.  (+info)

TY - JOUR. T1 - Renal oncocytoma. T2 - A case report. AU - Akiyama, H.. AU - Shidahara, K.. AU - Nasu, Yasutomo. AU - Tsushima, T.. AU - Ohmori, H.. PY - 1995. Y1 - 1995. N2 - A case of renal oncocytoma is reported. A 79-year-old man was referred to our clinic because of a right renal mass pointed out by ultrasonography during a health check up. Computed tomography (CT), magnetic resonance imaging (MRI), angiography, and dynamic MRI suggested a right renal cell carcinoma. Rt. total nephrectomy was performed. A pathological diagnosis of renal oncocytoma was made. Renal oncocytoma is a rare benign renal tumor. We herein discuss 87 cases of renal oncocytoma which have been reported in Japan.. AB - A case of renal oncocytoma is reported. A 79-year-old man was referred to our clinic because of a right renal mass pointed out by ultrasonography during a health check up. Computed tomography (CT), magnetic resonance imaging (MRI), angiography, and dynamic MRI suggested a right renal cell carcinoma. Rt. ...
Hurthle cell tumors are an infrequent neoplasm of the thyroid gland in adults. Hurthle cell tumors represent 4. 5% to 10% of all primary thyroid epithelial neoplasms in the foreign literature. It has been known as Hurthle cell tumor since Ewing was the first to use this term in 1928. Tumor occurring in an infant was described by Symmers(1941) and Morrow(1945). The authors experienced a case of congenital Hurthle cell tumor of the thyroid gland in a 2 months old boy. He was admitted to the pediatric surgical department because of a growing mass in the neck since birth. Ultrasonogram showed a huge lobulated homogenous solid mass with medium level echogenicity in the region of the thyroid gland. Subtotal thyroidectomy of right lobe and total thyroidectomy of left lobe were done. The specimen measures 2x3x1.5 cm and 7x3x3 cm, respectively. It was an encapsulated, yellow gray firm and solid mass. The cut surface was smooth, glistening and homogenous. Microscopicully, the tumor was composed of tightly ...
Chromophobe renal cell carcinoma is a rare type of kidney cancer that develops in cells that are involved in the production of urine. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis). Chromophobe renal cell carcinoma usually occurs in adults between the ages of 40 and 60, although it can appear in all age groups. This type of carcinoma is associated with Birt-Hogg-Dubé syndrome, an inherited disorder caused by a mutation in the FLCN gene. The FLCN gene is involved in regulating cell growth, and a mutation in this gene can cause cells to grow out of control. This situation places affected individuals at higher risk of developing chromophobe renal cell carcinoma as well as noncancerous growths in the kidneys, lungs, and hair follicles. Common symptoms include the presence of blood in the urine, ...
Chromophobe renal cell carcinoma is a rare type of kidney cancer that develops in cells that are involved in the production of urine. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis). Chromophobe renal cell carcinoma usually occurs in adults between the ages of 40 and 60, although it can appear in all age groups. This type of carcinoma is associated with Birt-Hogg-Dubé syndrome, an inherited disorder caused by a mutation in the FLCN gene. The FLCN gene is involved in regulating cell growth, and a mutation in this gene can cause cells to grow out of control. This situation places affected individuals at higher risk of developing chromophobe renal cell carcinoma as well as noncancerous growths in the kidneys, lungs, and hair follicles. Common symptoms include the presence of blood in the urine, ...
TY - JOUR. T1 - Chromophobe renal cell carcinoma with sarcomatoid differentiation. AU - Lauer, Scott R.. AU - Zhou, Ming. AU - Master, Viraj A.. AU - Osunkoya, Adeboye O.. PY - 2013/4/1. Y1 - 2013/4/1. N2 - OBJECTIVE: To investigate the clinicopathologic features of chromophobe renal cell carcinoma with sarcomatoid differentiation. STUDY DESIGN: A search was made through the surgical pathology and expert consult files of two major academic institutions from 2003 to 2011 for cases of chromophobe renal cell carcinoma with sarcomatoid differentiation. RESULTS: Fourteen patients were identified. The patients included 9 males (64%) and 5 females (36%). The mean patient age was 60.4 years (range, 40-82 years). There was a left-sided predominance: left (9 patients) and right (5 patients). The mean tumor size was 14.6 cm (range, 9.5-28.0 cm), and the mean percentage sarcomatoid differentiation was 67% (range, 30-99%). All tumors exhibited moderate to extensive areas of necrosis. The nonsarcomatoid ...
We report a carcinoma that is, to the best of our knowledge, the first case of a mixed mucus-secreting and oncocytic carcinoma of the thyroid. We also describe the histochemical, immunohistochemical, and ultrastructural features of this tumor. A 59-year-old man complaining of severe bone pain and weight loss underwent clinical and radiologic investigations. The studies revealed a nodule in the left thyroid lobe that was cold by (131)I scintiscan and multiple lytic lesions of the skeleton that showed increased uptake by (99m)Tc-Sestamibi scintiscan. Left hemithyroidectomy was performed and the surgical specimen contained a well-circumscribed nodule of 3 cm in the greatest diameter. Light microscopy showed an oncocytic carcinoma with an area of glandular and papillary proliferation of mucin-producing cells. A double histochemical approach (Alcian blue-periodic acid-Schiff and Alcian blue-high-iron diamine) combined with ultrastructural investigation confirmed the presence of true mucus
Discussion: Renal oncocytoma is a benign renal neoplasm which comprises 3-7 percent of adult kidney tumors. One half to two-thirds of these lesions are found incidentally. However, they can present with hematuria, flank pain and be palpable on clinical examination. Occasionally large bilateral tumors can present as renal failure. Oncocytomas have been reported in patients with Birt-Hogg-Dube and Von-Hippel Lindau syndromes. The most common cytogenetic abnormalities include loss of chromosomes 1 and y and translocations of 11q13. In very rare cases, both kidneys show diffuse involvement with macroscopic and microscopic oncocytoma, chromophobe renal cell carcinomas, and hybrid tumors with oncocytic changes of the adjacent renal tubules epithelium. These cases have been termed renal oncocytosis. The major differential diagnosis to consider is chromophobe renal cell carcinoma. Compared to oncocytoma, chromophobe renal cell carcinoma shows nuclear hyperchromasia with nuclear membrane irregularities. ...
TY - JOUR. T1 - Hurthle cell carcinoma of the thyroid gland. T2 - Prognostic factors and results of surgical treatment. AU - McDonald, M. P.. AU - Sanders, L. E.. AU - Silverman, M. L.. AU - Chan, H. S.. AU - Buyske, J.. AU - Ditkoff, B. A.. AU - Hay, Ian D. AU - Heller, K.. PY - 1996. Y1 - 1996. N2 - Background. Hurtle cell carcinomas of the thyroid are unusual variants of well-differentiated thyroid cancers. Considered more aggressive tumors, their optimal treatment is controversial. Our institutions half century of experience, the largest series to date, includes 40 patients with Hurthle cell carcinomas of 1000 well-differentiated thyroid cancers. Methods. A retrospective study was carried out on 40 patients. Results: Seventy-two percent were female, with a median age of 53 years. Median follow-up was 9 years. With the AMES risk stratification (age, distant metastasis, capsular extent, tumor size), among the 21 high-risk patients, 10 (48%) had a recurrence or died, with median time to ...
By Montone, Kathleen T Baloch, Zubair W; LiVolsi, Virginia A Context.-Hurthle cells are eosinophilic, follicular-derived cells that are associated with a variety of nonneoplastic and neoplastic thyroid lesions. The differential diagnosis of Hurthle cell lesions is quite broad. Objective.-To review the pathologic conditions associated with Hurthle cells in the thyroid and to discuss pathology of thyroid lesions associated with oncocytic cytology. Data Sources.-A variety of thyroid nonneoplastic (autoimmune thyroiditis, multinodular goiter) and neoplastic conditions (Hurthle cell adenoma, Hurthle cell carcinoma) are associated with Hurthle cell cytology. In addition, there are several thyroid neoplasms that should be considered when one observes a Hurthle cell neoplasm in the thyroid (oncocytic variant of medullary carcinoma, several variants of papillary thyroid carcinoma). Conclusions.-Oncocytic cytology is seen in a variety of thyroid conditions that are associated with a broad differential ...
Background: Thyroid nodules are rare in children compared to adults. Although most thyroid nodules are benign, the risk of malignancy is greater in pediatric patients.. Case: We described a 10-year-old boy who presented with a right sided thyroid nodule that was 12×8 mm. He had not cervical lymphadenopathy. His fine needle aspiration biopsy cytology was benign. It was subsequently diagnosed as a Hurthle cell adenoma after thyroidectomy. In histopathological evaluation, there was no vascular and capsular invasion.. Conclusion: Hurthle cell adenoma is very rare during childhood. We suggest that follow-up of thyroid nodule is very important. ...
An inherited condition characterized by the development of kidney oncocytomas which are often bilateral and multifocal. This condition may be connected to Birt-Hogg-Dube syndrome.
Despite multiple studies, many clinicopathologic issues about chromophobe renal cell carcinoma (RCC) remain contentious; for example, its biological behavior-whether better or similar to papillary RCC, the incidence of sarcomatoid features, and whether pathologic features such as necrosis, nuclear g
ABSTRACT Objective: To evaluate the preoperative imaging manifestation and therapeutic effect of laparoscopic simple enucleation (SE) for localized chromophobe renal cell carcinoma (chRCC).. Materials and Methods: Clinical data of 36 patients who underwent laparoscopic SE of localized chRCC at our institute were retrospectively analyzed. All patients underwent preoperative renal protocol CT (unenhanced, arterial, venous, and delayed images). CT scan characteristics were evaluated. After intraoperative occlusion of the renal artery, the tumor was free bluntly along the pseudocapsule and enucleated totally. The patients were followed up regularly after the operation.. Results: Mean tumor diameter was 3.9±1.0 cm, 80% of tumors were homogeneous and all the tumors had complete pseudocapsule. The attenuation values were slightly lower than normal renal cortex and degree of enhancement of the tumors were significantly lower than normal renal cortex. Mean operation time was 104.3±18.2 min. Mean warm ...
TY - JOUR. T1 - The somatic genomic landscape of chromophobe renal cell carcinoma. AU - The Cancer Genome Atlas Research Network. AU - Davis, Caleb F.. AU - Ricketts, Christopher J.. AU - Wang, Min. AU - Yang, Lixing. AU - Cherniack, Andrew D.. AU - Shen, Hui. AU - Buhay, Christian. AU - Kang, Hyojin. AU - Kim, Sang Cheol. AU - Fahey, Catherine C.. AU - Hacker, Kathryn E.. AU - Bhanot, Gyan. AU - Gordenin, Dmitry A.. AU - Chu, Andy. AU - Gunaratne, Preethi H.. AU - Biehl, Michael. AU - Seth, Sahil. AU - Kaipparettu, Benny A.. AU - Bristow, Christopher A.. AU - Donehower, Lawrence A.. AU - Wallen, Eric M.. AU - Smith, Angela B.. AU - Tickoo, Satish K.. AU - Tamboli, Pheroze. AU - Reuter, Victor. AU - Schmidt, Laura S.. AU - Hsieh, James J.. AU - Choueiri, Toni K.. AU - Hakimi, A. Ari. AU - Chin, Lynda. AU - Meyerson, Matthew. AU - Kucherlapati, Raju. AU - Park, Woong Yang. AU - Robertson, A. Gordon. AU - Laird, Peter W.. AU - Henske, Elizabeth P.. AU - Kwiatkowski, David J.. AU - Park, Peter ...
TY - JOUR. T1 - Hurthle Cell Carcinoma of the Thyroid Gland. T2 - Color Doppler Ultrasound and CT appearance. AU - Chen, Chia-Yuen. AU - Chou, YH. AU - Hsu, CC. AU - Chang, KM. AU - Tiu, CM. AU - Chang, C-Y. AU - Yu, C. PY - 1995. Y1 - 1995. M3 - Article. VL - 3. SP - 33. EP - 37. JO - Journal of Medical Ultrasound. JF - Journal of Medical Ultrasound. SN - 0929-6441. ER - ...
Hurthle cell carcinoma is a rare, aggressive type of thyroid cancer. Treatments include surgery, radioactive iodine therapy, radiation therapy and chemotherapy.
These images are intended for educational purposes and may be freely used for such as long as the Papanicolaou Society and the Bethesda System for Reporting Thyroid Cytopathology is credited ...
The rule is do not panic when you here Hurthle cells are present in your biopsy 85% are found in benign goiter and thyroiditis nodules.. Delay surgery until you sort out if you really need it. Finding more Hurthle cells in atypical biopsy results can lead to too many surgeries without molecular marker testing on the nodule.. Call Matt for details of my evaluation of the presence of Hurthle cells seen in your biopsy.. 310-393-8860. [email protected] ...
Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology. 1991 Nov;19(5):403-10 ...
Datasets are collections of data. BioGPS has thousands of datasets available for browsing and which can be easily viewed in our interactive data chart. Learn more.. ...
Hurthle (HEERT-luh) cell cancer is a rare cancer that affects the thyroid gland.. The thyroid is a butterfly-shaped gland in the base of your neck. It secretes hormones that are essential for regulating your bodys metabolism.. Hurthle cell cancer is also called Hurthle cell carcinoma or oxyphilic cell carcinoma. Hurthle cell cancer is one of several types of cancers that affect the thyroid. ...
B. c. d. e. Renal oncocytoma Renal adenocarcinoma Renal metanephric adenoma Transitional cell carcinoma Nephroblastoma 43. Regarding nephroblastoma a. b. c. d. e. It is also known as Wilms tumour It classically occurs in young children Nephroblastomas are purely epithelial in component It is bilateral in 20 per cent of cases It may present with failure to thrive 44. A 60-year-old male is referred to urology clinic as his GP is concerned that he may have symptoms suggestive of renal cancer a. List the common presenting symptoms of renal cell carcinoma b. Manifestations include a purpuric rash on the ankles, dorsum of the legs and buttocks, colicky abdominal pain, fleeting polyarthritis of large joints and microscopic haematuria. • Rapidly progressive glomerulonephritis (crescentic) is characterized by the presence of crescents (epithelial cell proliferation and monocyte accumulation in Bowmans space), which is usually associated with severe renal injury. g. sinusitis, nasal bridge collapse, ...
Question - What does oncocytic and hurthle cell features mean?. Ask a Doctor about diagnosis, treatment and medication for Hurthle cell cancer, Ask an Oncologist
Liz, I guess you can easily look up the stats in various places for general information e.g. here: http://www.cancer.gov/statistics/find Roughly, it looks this way - kidney cancer is one of the less frequent cancers. Figures in the US and UK are fairly similar and for 2009, in the UK Kidney cancer is the eighth most common cancer in the UK (2009), accounting for around 3% of all new cases. It is the sixth most common cancer among men in the UK (2009), accounting for more than 3% of all new cases of cancer in males. It is the ninth most common cancer among women in the UK (2009), responsible for more than 2% of all new cases of cancer in females.. In both the US and Europe, chromophobe RCC accounts for only about one in twenty cases of RCC. So, on the above figures, You could reckon that chromophobe RCC would account for around 0.15% of cancer cases in men and 0.1% of cancer cases in women. This needs to be tweaked just a little because although kidney cancer is more common in males than in ...
hurthle - MedHelps hurthle Center for Information, Symptoms, Resources, Treatments and Tools for hurthle. Find hurthle information, treatments for hurthle and hurthle symptoms.
Case Reports in Endocrinology is a peer-reviewed, Open Access journal that publishes case reports related to the endocrine system and its associated diseases.
A tumor of the thyroid gland, usually benign. Oncocytomas are mainly made up of Hurtle Cells (large cells). Occasionally they may become locally invasive and, in rare instances, metastasize.. Tags: Cancer Dictionary, O, Uncategorized. ...
[Oxyphil-cell adenoma (oncocytoma) of the caruncle (authors transl)].: By histological examination of 42 caruncle tumors we found 5 oncocytomas. All the patien
Rohan S، Tu JJ، Kao J، Mukherjee P، Campagne F، Zhou XK، Hyjek E، Alonso MA، Chen YT (Dec 2006). Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. Clinical Cancer Research. 12 (23): 6937-45. PMID 17145811. doi:10.1158/1078-0432.CCR-06-1268. ...
Follicular and Hurthle cell cancers are two different types of cancer, but they are often considered in the same category. They can occur at any age, but are more likely in older people.
CASE REPORT: A 28-year-old healthy male presented with a history of right upper quadrant fullness and discomfort. Hepatomegaly was expected on examination. Ultrasonographic assessment revealed a normal liver size and echo texture. However, a large cystic mass measuring 15.7×12.8 cm was found arising from the right kidney which showed no internal vascularity but turbid fluid and debris within the dependent regions of the mass. Multiphase computed tomography scan showed a large unilocular cystic mass with enhancing mural nodules. There was no lymphovascular or peri-renal invasion. The patient underwent uneventful total right renal nephrectomy. Histological examination revealed a chromophobe renal cell carcinoma of grade II ...
Xiao, Y.; Rabien, A.; Buschow, R.; Amstislavskiy, V.; Busch, J.; Kilic, E.; Villegas, S. L.; Timmermann, B.; Schütte, M.; Mielke, T. et al.; Yaspo, M.-L.; Jung, K.; Meierhofer, D.: Endocytosis-mediated replenishment of amino acids favors cancer cell proliferation and survival in chromophobe renal cell carcinoma. Cancer research: an official organ of the American Association for Cancer Research 2020 (2020 ...
Speicher, Michael R.; Schoell, B.; Manoir, Stanislas du; Schröck, Evelin; Ried, Thomas; Cremer, Thomas; Störkel, S. und Kovacs, Gyula (1994): Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization. In: The American Journal of Pathology, Vol. 145, Nr. 2: S. 356-364 [PDF, 2MB] ...
Hürthle Cell Carcinoma is a type of thyroid cancer that is not very common. This article provides information about Hurthle Cell carcinoma, its diagnosis and treatment.
Despite the World Health Organizations inclusion of this entity as follicular cell cancer (FCC), some authors assert that Hurthle cell carcinoma (HCC) remains a distinct clinical entity. For example, only ~10% of metastases from HCC take up radioiodine, compared with 75% of metastases from FCC (Yutan). Compared to FCC, HCC is more often multifocal, bilateral and more frequently involves regional nodes. Thus, HCC appears to be a more aggressive tumor than FCC, with a greater tendency to metastasize to distant sites and a higher mortality rate (Yutan). ...
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
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TY - JOUR. T1 - Selective Efficacy of Temsirolimus on Bone Metastases in Chromophobe Renal Cell Carcinoma. AU - Huelsmann, Lorel. AU - Kim, D. Nathan W.. AU - Hannan, Raquibul. AU - Watumull, Lori M.. AU - Brugarolas, James. PY - 2015/8/1. Y1 - 2015/8/1. KW - Bone remodeling. KW - Everolimus. KW - Mammalian target of rapamycin (mTOR). KW - Osteoclasts. KW - Tuberous Sclerosis Complex 1 (TSC1). UR - http://www.scopus.com/inward/record.url?scp=84936985359&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84936985359&partnerID=8YFLogxK. U2 - 10.1016/j.clgc.2014.12.007. DO - 10.1016/j.clgc.2014.12.007. M3 - Article. C2 - 25620636. AN - SCOPUS:84936985359. VL - 13. SP - e321-e323. JO - Clinical Genitourinary Cancer. JF - Clinical Genitourinary Cancer. SN - 1558-7673. IS - 4. ER - ...
Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary ...
RCC treatment has been classically derived from clinical trials that incorporated all histologies comprising clear cell, papillary, chromophobe, and other rarer subtypes. Most recently, novel therapies (sunitinib and sorafenib) have shown significant clinical activity in advanced RCC and have changed the standard of care in this disease [1-3]. However, pivotal studies with these drugs were performed exclusively in patients with clear cell histology. Therefore, the optimal therapy for papillary and chromophobe histologies remains unknown. Overall, ChRCC is considered to portend a good prognosis and is associated with earlier-stage tumors and longer overall survival in comparison with CCRCC. There are conflicting reports on prognosis in metastatic disease, and few data on response to treatment exist. Increased VEGF-6 and c-Kit (i.e., mast/stem cell growth factor receptor; proto-oncogene c-Kit; tyrosine-protein kinase Kit; or CD117) expressions have been reported in ChRCC, but the relevance of this ...
A chromophobe is a histological structure that does not stain readily, and thus appears relatively pale under the microscope. Chromophobe cells are one of three cell types, the others being basophils and acidophils. One type of chromophobe cell is known as amphophils. Amphophils are epithelial cells found in the anterior and intermediate lobes of the pituitary. Together, these epithelial cells are responsible for producing the hormones of the anterior pituitary and releasing them into the bloodstream. Melanotrophs (also, Melanotropes) are another type of chromophobe which secrete melanocyte stimulating hormone (MSH). Chromophobe also refers to a type of renal cell carcinoma (distinct from clear cell). Chromophobe renal cancer is part of a rare, genetic disorder known as Birt-Hogg-Dubé syndrome. While renal cell carcinoma is one of the most frequently diagnosed cancers, chromophobe renal cancer only accounts for five percent of renal cancer cases. Furthermore, 30% of patients with ...
Brian I. Rini, MD, presents a case study focused on the treatment of a 64 year-old male who presented with recurrent lung nodules 9 years after a left radical nephrectomy for a clear-cell renal ...
(2009) Hirata et al. Nishinihon Journal of Urology. The association of renal angiomyolipoma and renal oncocytoma within the same kidney is rare, with only 10 cases having been reported in the literature previously. A 65-year-old woman consulted our hospital with the chief complaint of general fat...
TY - JOUR. T1 - Diagnostic utility of S100A1 expression in renal cell neoplasms. T2 - An immunohistochemical and quantitative RT-PCR study. AU - Rocca, Paolo Cossu. AU - Brunelli, Matteo. AU - Gobbo, Stefano. AU - Eccher, Albino. AU - Bragantini, Emma. AU - Mina, Maria M.. AU - Ficarra, Vincenzo. AU - Zattoni, Filiberto. AU - Zamò, Alberto. AU - Pea, Maurizio. AU - Scarpa, Aldo. AU - Chilosi, Marco. AU - Menestrina, Fabio. AU - Bonetti, Franco. AU - Eble, John N.. AU - Martignoni, Guido. PY - 2007/7/1. Y1 - 2007/7/1. N2 - S100A1 is a calcium-binding protein, which has been recently found in renal cell neoplasms. We evaluated the diagnostic utility of immunohistochemical detection of S100A1 in 164 renal cell neoplasms. Forty-one clear cell, 32 papillary, and 51 chromophobe renal cell carcinomas, and 40 oncocytomas, 164 samples of normal renal parenchyma adjacent to the tumors and 13 fetal kidneys were analyzed. The levels of S100A1 mRNA detected by quantitative RT-PCR analysis of frozen tissues ...
When is A Thyroid nodule with Hurthle cells not a neoplasm but part of a chronic thyroidits? Answer: When there are lymphocytes seen in the Hurthle cell nodule.. ...
Ruiz-Cordero R, Rao P, Li L, Qi Y, Atherton D, Peng B, Singh RR, Kim TB, Kawakami F, Routbort MJ, Alouch N, Chow CB, Tang X, Lu W, Brimo F, Matin SF, Wood CG, Tannir NM, Wistuba II, Chen K, Wang J, Medeiros LJ, Karam JA, Tamboli P, Sircar K. Hybrid oncocytic/chromophobe renal tumors are molecularly distinct from oncocytoma and chromophobe renal cell carcinoma. Mod Pathol. 2019 Jun 23. doi: 10.1038/s41379-019-0304-y. [Epub ahead of print] PubMed PMID: 31231128 ...
METASTATIC CHROMOPHOBE RCC continued from page 11 chromophobe RCC. The rest had clear cell mRCC. Overall and progression-free survival rates; time to treatment failure; overall, par-tial, and complete response rates; and stable and progressive disease were calculated. fi ed in low, intermediate, and high risk, remarked Yip. When combined, all these factors we uncovered had an appropriate refl ection in stratifying just like wed see in clear cell RCCs. In this study, patients with IMDC fa-vorable criteria (18%) had median overall survival of 31.4 months. Those with in-termediate risk (59%) achieved an over-all survival of 27.3 months, and poor risk patients (23%) had overall survival of 4.8 months. In the past, we didnt have a clear understanding of whether this treatment was applicable to such a rare subtype. Now… we can tell our patients in clinic that theres good grounded evidence for why we can treat them similarly to how we would patients with clear cell RCC. Evaluating Outcomes ...
Large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askenazy cells ...
Therefore, these results do suggest that Ketorolac treatment regimens could serve successfully induce shortness of breath in which sd rats through inhibition of stool and good urine excretion. About the only problem you can get with Ketorolac is blue lips involuntarily and fingernails and heroines that usually means you are effectively taking too much. Below we report the reversal of progressive shortness of breath in a desperate patient with the primary hurthle cell cancer following IVIG admin
was well differentiated papillary/follicular with hurthle cell involvement. If they did the pathology correct and it was papillary, it cant change, unless hurthle cells were present but indetectable at the time. I think youre safe in your diagnosis.. My thyroglobulin was under 1 for three years, I was fine, then it started to rise, and my doctors didnt tell me util I went up to 6. It went from under 1 to 2, then 4, then 6, then 9. Most insurances wont ok a PET scan until your level is over 10, but my insurance let me have one. It showed a spot in my hip bone. I had another RAI treatment in the hospital, but the uptake wasnt enough to kill the cancer there, because hurthle cell doesnt absorb radio-iodine as well as other thyroid cancers. After that my TG kept rising, and a pet scan showed the same spot in my hip. I had to have surgery to remove it. After that, my tg kept rising. At 29, my PET scan was clean, or so they thought. Six month later my TG jumped to 130. Another PET scan showed ...
The oncogenic versus suppressor roles of mitochondrial genes has been long debated. Peculiar features of mitochondrial genetics such as hetero/homoplasmy and mutation threshold are seldom taken into account in this debate. Mitochondrial DNA (mtDNA) mutations generally have been claimed to be pro-tumorigenic, but they are also hallmarks of mostly benign oncocytic tumors where they help reduce adaptation to hypoxia by destablizing hypoxia-inducible factor-1α (HIF1α). To determine the influence of a disassembling mtDNA mutation and its hetero/homoplasmy on tumorigenic and metastatic potential, we injected mice with tumor cells harboring different loads of the gene MTND1 m.3571insC. Cell cultures obtained from tumor xenografts were then analyzed to correlate energetic competence, apoptosis, α-ketoglutarate/succinate ratio and HIF1α stabilization with the mutation load. A threshold level for the anti-tumorigenic effect of MTND1 m.3571insC mutation was defined, above which tumor growth and ...
At this point, INTERNIST-I reports concerning the initial differential diagnosis that will be the focus of problem solving attention. Three lists are displayed, labeled respectively DISREGARDING, CONSIDERING, and RULEOUT. The CONSIDERING list identifies those positive findings whose differential diagnostic tasks were combined in coming to the differential diagnostic focus, which is described by the RULEOUT list. The DISREGARDING list tells what positive findings are not consistent with the differential diagnosis as formulated and are therefore being disregarded for the moment; they will, however, be attended to in due course. The keyword RULEOUT indicates what strategy INTERNIST-I is going to pursue relative to this task definition: in this case, as in any case when the differential list contains five or more alternatives, the program will try to find questions to ask which, if the response is negative, will serve to downgrade the score of one or more diagnoses on the list. While pursuing a ...
Oncocytoma, Carcinoma, Cell, Kidney, Renal Cell Carcinoma, Cytoplasm, Survival, Disease, Work, Cancers, Human, Prognosis, Adjustment, Axis, Cancer, Cells, Immunohistochemistry, Ligands, Necrosis, Patients
"Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomas". BMC Endocrine Disorders. 7: 8. doi:10.1186/1472- ...
... benign neoplastic growth also called an oxyphilic adenoma. It comprises about 1% of all salivary gland tumors. The ... Grossly, oncocytic adenomas are encapsulated, solid nodules with a characteristic brown cut surface. The gross appearance of a ... They may be bilateral.[citation needed] Thyroid oncocytomas can be benign (adenomas) or malignant (carcinomas). Also known as ... There are no reliable cytologic features which distinguish oncocytic adenomas from carcinomas and the only criterion for a ...
... may be found as a less common salivary gland neoplasm also known as oxyphilic adenoma. Renal oncocytoma, a kidney tumour ... Also known as: Hürthle cell (thyroid gland only) Oxyphilic cell, Askanazy cell Apocrine metaplasia (breast gland only). Derived ...
A Hürthle cell adenoma or a minimally invasive tumor can be treated by a thyroid lobectomy, although some surgeons will perform ... Although the terms oncocyte, oxyphilic cell, and Hürthle cell are used interchangeably, Hürthle cell is used only to indicate ... Hürthle cell adenomas are most likely diagnosed much more frequently than Hürthle cell carcinomas. The female to male ratio for ... Adenoma Oncocytoma Oxyphil cell "Endocrine Pathology". Retrieved 2009-05-07. Grani, Giorgio; Lamartina, Livia; Durante, Cosimo ...
Oxyphilic adenoma Oncocytic adenoma Oncocytoma Hurthle cell adenoma (C73.9) Hurthle cell tumor Follicular adenoma, oxyphilic ... Black adenoma Pigmented adenoma M8373/0 Adrenal cortical adenoma, clear cell (C74.0) M8374/0 Adrenal cortical adenoma, ... oxyphilic cell (C73.9) M8300/0 Basophil adenoma (C75.1) Mucoid cell adenoma M8300/3 Basophil carcinoma (C75.1) Basophil ... NOS Pick tubular adenoma Sertoli cell adenoma Tubular androblastoma, NOS Testicular adenoma M8640/3 Sertoli cell carcinoma (C62 ...
... adenoma, liver cell MeSH C04.557.470.035.140 - adenoma, oxyphilic MeSH C04.557.470.035.155 - adenoma, pleomorphic MeSH C04.557. ... adenoma, bile duct MeSH C04.557.470.035.095 - adenoma, chromophobe MeSH C04.557.470.035.100 - adenoma, islet cell MeSH C04.557. ... adenoma MeSH C04.557.470.035.012 - acth-secreting pituitary adenoma MeSH C04.557.470.035.025 - adenoma, acidophil MeSH C04.557. ... adenoma, acidophil MeSH C04.557.465.625.650.075 - adenoma, basophil MeSH C04.557.465.625.650.095 - adenoma, chromophobe MeSH ...
oxyphilic adenoma synonyms, oxyphilic adenoma pronunciation, oxyphilic adenoma translation, English dictionary definition of ... oxyphilic adenoma. n. pl. ad·e·no·mas or ad·e·no·ma·ta A benign epithelial tumor having a glandular origin and structure. ad′e· ... Oxyphilic adenoma - definition of oxyphilic adenoma by The Free Dictionary https://www.thefreedictionary.com/oxyphilic+adenoma ... adenoma. (redirected from oxyphilic adenoma). Also found in: Thesaurus, Medical, Encyclopedia. ad·e·no·ma. (ăd′n-ō′mə). n. pl. ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
Build: Fri Jul 27 09:23:34 EDT 2018 (commit: a5c8d99). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
OXYPHILIC GRANULAR CELL ADENOMA (ONCOCYTOMA) OF THE PAROTID. LANE, STANLEY L. LANE, STANLEY L. Less ...
Adenoma, Oxyphilic. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. Endocrine System Diseases. ...
"Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomas". BMC Endocrine Disorders. 7: 8. doi:10.1186/1472- ...
Adenoma, Oxyphilic / genetics* * Adenoma, Oxyphilic / pathology * Adolescent * Adult * Carcinoma, Papillary / genetics* * ...
oxyphilic adenoma. - elite association - COSMIC cancer census association via MalaCards Search FNIP2 in MalaCards View complete ...
Adenoma, Oxyphilic / pathology * Adult * Aged * Carcinoma, Renal Cell / genetics * Carcinoma, Renal Cell / pathology* ...
What is Adenoma of the adrenal gland? Meaning of Adenoma of the adrenal gland medical term. What does Adenoma of the adrenal ... Looking for online definition of Adenoma of the adrenal gland in the Medical Dictionary? Adenoma of the adrenal gland ... adenoma, oxyphilic,. n See oncocytoma.. adenoma. a benign epithelial tumor in which the cells form recognizable glandular ... nonsecreting adenoma (nonsecretory adenoma) endocrine-inactive adenoma.. null-cell adenoma a pituitary adenoma whose cells give ...
... nipple adenoma explanation free. What is nipple adenoma? Meaning of nipple adenoma medical term. What does nipple adenoma mean? ... Looking for online definition of nipple adenoma in the Medical Dictionary? ... adenoma, oxyphilic,. n See oncocytoma.. adenoma. a benign epithelial tumor in which the cells form recognizable glandular ... nonsecreting adenoma (nonsecretory adenoma) endocrine-inactive adenoma.. null-cell adenoma a pituitary adenoma whose cells give ...
... benign neoplastic growth also called an oxyphilic adenoma. It comprises about 1% of all salivary gland tumors. The ... Grossly, oncocytic adenomas are encapsulated, solid nodules with a characteristic brown cut surface. The gross appearance of a ... They may be bilateral.[citation needed] Thyroid oncocytomas can be benign (adenomas) or malignant (carcinomas). Also known as ... There are no reliable cytologic features which distinguish oncocytic adenomas from carcinomas and the only criterion for a ...
The histological diagnosis was that of oxyphilic adenoma with an oncocytic appearance compatible with oncocytoma. In view of ...
Water-clear cell adenoma (WCCA) of the parathyroid gland is an exceedingly rare neoplasm. To date, 17 cases have been reported ... Parathyroid adenomas are usually composed of chief cells or oxyphilic cells. In contrast, WCCA are composed of uniform ... 2]. Indeed, adenoma size seems to have no correlation to initial calcium levels in the 13 cases with reported adenoma size and ... Water-clear cell adenoma (WCCA) of the parathyroid gland is an exceedingly rare neoplasm. To date, 17 cases have been reported ...
Oxyphilic Adenoma (Oncocytoma) 06/01/2012 - "Three microRNAs and 12 mRNA genes had a ≥98% coding region contained within CNV ...
41.3%), chromophobic adenomas (. , 4.3%), and oxyphilic adenoma (. , 2.2%). Disturbed circulation was responsible for the ... Seventeen adenomas exhibited all three features; 4 adenomas contained necrotic foci and areas of hemorrhage, and 1 adenoma ... 3 basophilic-oxyphilic, 1 oxyphilic-chromophobic) and the rest oxyphilic. ... Light microscopy was used to verify diagnosis of pituitary adenomas (basophilic, oxyphilic, chromophobic and mixed), carcinoid ...
DV, Mykiskova, I, Kutzner, H. "Hidradenoma papilliferum with oxyphilic metaplasia. A clinicopathological study of 18 cases, ... Scurry, J, van der Putte, SC, Pyman, J, Chetty, N, Szabo, R. " Mammary-like gland adenoma of the vulva: review of 46 cases". ... Hidradenoma Papilliferum (Papillary Hidradenoma, Mammary-like Gland Adenoma) ( 216.9=Benign Skin Neoplasm, ICD 10 - other ... The histologic differential diagnosis includes syringocystadenoma papilliferum and tubular apocrine adenoma. In general, the ...
intraoperative complications, nephrectomy, oxyphilic adenoma, postoperative complications, renal oncocytoma. UCL classification ...
Oncocytic (Hürthle cell, oxyphilic cell, askanazi cell) adenoma: transcapsular and/or vascular invasion absent.. ... Oncocytic adenomas are treated with a simple lobectomy or nodulectomy, which is curative but should not be enucleated, as an ... Neuro-Endocrine/Endocrine system: Thyroid::Oncocytoic tumor (Hürthle cells adenoma). WHO/OMS Classification. Neuro-Endocrine/ ... The mean age at diagnosis was 43 years for adenomas and 52 for oncocytic carcinomas in a recent series. There is a female ...
12 Synonyms for this tumor include oncocytic adenoma, oxyphilic granular-cell adenoma, and oxyphilic adenoma. ... Bilateral and multifocal parotid tumors on CT also render pleomorphic adenomas and basal cell adenomas less likely differential ... a feature seen mainly with pleomorphic adenomas but also in Warthin tumors and basal cell adenomas.2,17,32,33 Three of our ... basal cell adenomas, and, to a lesser degree, pleomorphic adenomas. However, when taken together, the diagnosis of a benign ...
2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were ... 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were ... 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were ... 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were ...
Oxyphilic Adenoma * Genetic Techniques 2000 BCG-induced urinary cytokines inhibit microvascular endothelial cell proliferation ...
Oxyphilic Adenoma Medicine & Life Sciences * Clear-cell metastatic renal cell carcinoma Medicine & Life Sciences ...
Oxyphilic parathyroid adenoma and lithium therapy. Lancet. 1998 Sep 26; 352 (9133): 1070. ...
... the increased radiotracer uptake is not exclusive to the mitochondria-rich oxyphilic cells in parathyroid adenomas. ... Besides a left lower pole parathyroid adenoma, left posterior occipital lobe focal MIBI uptake was also demonstrated on the ... Localisation of parathyroid adenomas reduces operating time and perioperative morbidity following parathyroidectomy.1 2 ... These demonstrate focal uptake within the left lower pole parathyroid adenoma (blue arrow, image A). The left occipital ...
Adenoma, Oxyphilic, radionuclide imaging, Adult, Aged, Blotting, Northern, Carcinoma, Medullary, Carcinoma, Papillary, ... T/B values in the patient with Hürthle cell adenoma were similar to those found in the contralateral thyroid lobe with goitre. ... Three cases of MTC, Hürthle cell adenoma and papillary thyroid cancer are reported with preoperative scintigraphy, T/B ratios ...
A 45-year-old woman was referred to our Nuclear Department with a palpable neck nodule suspicious for parathyroid adenoma. She ... This case report presents the significance and practicality of 99mTc-tetrofosmin for the diagnosis of parathyroid adenomas with ... of reverse 99m Tc-tetrofosmin scintigraphy as a useful and safe examination technique for the diagnosis of parathyroid adenomas ... Tc-sestamibi is the most frequently used radionuclide agent for the detection of parathyroid adenomas in the clinical setting. ...
... adrenal cortical adenoma, NOS, brainstem, kidney, renal cell carcinoma, chromophobe type ... oxyphilic adenoma, stomach, gastrointestinal stromal sarcoma, frontal lobe, oligodendroglioma, NOS, brain stem, ependymoma, NOS ... kidney, oxyphilic adenoma. Expression (log2-scale):10.36903. Number of Samples:31 Neoplasm. kidney, oxyphilic adenoma. ... cortex of adrenal gland, adrenal cortical adenoma, NOS. Expression (log2-scale):9.664588. Number of Samples:80 Neoplasm. cortex ...
MeSH-major] Adenoma / pathology. Adenoma, Oxyphilic / pathology. Neoplasm Recurrence, Local / pathology. Thyroid Neoplasms / ... MeSH-minor] Adenoma / blood supply. Adenoma / radiography. Adenoma / surgery. Adolescent. Adult. Aged. Aged, 80 and over. ... MeSH-minor] Adenoma, Oxyphilic / pathology. Adult. Aged. Female. Humans. Male. Middle Aged. Thyroid Gland / pathology. Thyroid ... MeSH-major] Adenoma / diagnosis. Burkitt Lymphoma / diagnosis. Thyroid Neoplasms / diagnosis. Thyroid Nodule / diagnosis ...
... aldosterone-producing adenoma, adrenal gland, unspecified, kidney, renal cell carcinoma, chromophobe type, intrahepatic bile ... duct, cholangiocarcinoma, metastatic, cortex of adrenal gland, adrenal cortical adenoma, NOS ... oxyphilic adenoma, kidney, renal cell carcinoma, chromophobe type, unstated behavior, liver, hepatocellular carcinoma, NOS, ... kidney, oxyphilic adenoma. Expression (log2-scale):15.126887. Number of Samples:31 Neoplasm. kidney, oxyphilic adenoma. ...
  • 1) The terms oncocytic carcinoma, oncocytic adenocarcinoma, malignant oncocytoma, and malignant oxyphilic adenoma are synonymous. (thefreedictionary.com)
  • citation needed] The salivary gland oncocytoma is a well-circumscribed, benign neoplastic growth also called an oxyphilic adenoma. (wikipedia.org)
  • The gross appearance of a minimally invasive oncocytic carcinoma is indistinguishable to that of an adenoma, while widely invasive oncocytic carcinomas are obviously invasive macroscopically and display pervasive vascular invasion with multifocal involvement of the thyroid gland. (wikipedia.org)
  • A variety of thyroid nonneoplastic (autoimmune thyroiditis, multinodular goiter) and neoplastic conditions (Hurthle cell adenoma, Hurthle cell carcinoma) are associated with Hurthle cell cytology. (redorbit.com)
  • A full biochemical evaluation is warranted to screen secreting adrenal adenomas as well as to evaluate adrenal cortical carcinoma. (nebraska.edu)
  • Las caracter sticas presentadas incluyeron necrosis isqu mica masiva posterior a toma de biopsia por aspiraci n, tama o mayor al esperado en un adenoma, coexistencia con una neoplasia maligna independiente y caracter sticas histol gicas similares a las observadas en carcinoma papilar. (medigraphic.com)
  • P. Lalire, M. Zalzali, C. Garbar, C. Bruna-Muraille, D. Morland, Incidental detection of oxyphilic papillary thyroid carcinoma by 18F-fluorocholine PET/CT. (springer.com)
  • M-8201/3 Cribriform carcinoma, NOS M-8202/0 Microcystic adenoma (C25. (wolfbane.com)
  • Oncocytomas and oxyphilic adenomas are other tumors which may have increased radiopharmaceutical uptake. (blogspot.com)
  • The most common benign salivary gland tumor is the benign mixed tumor or pleomorphic adenoma, which accounts for 70% of parotid tumors and 50% of all salivary gland tumors. (health.am)
  • Oncocytomas are benign tumors composed of large oxyphilic cells called oncocytes. (health.am)
  • Oxyphilic tumors of the female and male genital tracts. (medigraphic.com)
  • Of the benign epithelial tumors, the mixed tumor (pleomorphic adenoma) is the most common. (medscape.com)
  • The etiology of these tumors is unknown, but the possibility of an adenoma gene currently is under investigation for its involvement in the development of pleomorphic adenomas. (medscape.com)
  • citation needed] Thyroid oncocytomas can be benign (adenomas) or malignant (carcinomas). (wikipedia.org)
  • Oncocytic adenomas are treated with a simple lobectomy or nodulectomy, which is curative but should not be enucleated, as an evaluation of their capsule is essential for the pathologist to determine whether the tumor is benign or malignant. (atlasgeneticsoncology.org)
  • Inclusion criteria were: the result of fine needle aspiration biopsy " suspicious for follicular/oxyphilic neoplasm", absence of invasive neoplasm features as follows infiltration of surrounding tissue or lymph nodes/distant metastases, informed consent. (bvsalud.org)
  • hepatocellular adenoma a large, fleshy, hypervascular tumor of the liver occurring chiefly in women of childbearing age and associated with oral contraceptive use. (thefreedictionary.com)
  • 1 , 4 , 5 , 7 , 10 - 12 Synonyms for this tumor include oncocytic adenoma, oxyphilic granular-cell adenoma, and oxyphilic adenoma. (ajnr.org)
  • En nuestro caso, la presencia de dos criterios histológicos menores lo clasifican como un tumor con potencial maligno. (bvsalud.org)
  • All three RAS genes ( H-RAS, K-RAS, and N-RAS ) are implicated in thyroid tumor formation from follicular cells, including 20% to 40% of benign follicular adenomas, 40% to 50% of FTC (including 15% to 20% of oxyphilic variants), 10% to 20% of PTC (almost exclusively follicular variants of PTC), and 25% of PDTC. (clinicalgate.com)
  • M-814:M-838) Adenomas and adenocarcinomas M-8140/0 Adenoma, NOS M-8140/1 Atypical adenoma M-8140/2 Adenocarcinoma in situ, NOS M-8140/3 Adenocarcinoma, NOS M-8140/6 Adenocarcinoma, metastatic, NOS M-8141/3 Scirrhous adenocarcinoma M-8142/3 Linitis plastica (C16. (wolfbane.com)
  • M-8146/0 Monomorphic adenoma M-8147/0 Basal cell adenoma M-8147/3 Basal cell adenocarcinoma M-8148/2 Glandular intraepithelial neoplasia, grade III M-8149/0 Canalicular adenoma M-8150/0 Islet cell adenoma (C25. (wolfbane.com)
  • M-8210/0 Adenomatous polyp, NOS M-8210/2 Adenocarcinoma in situ in adenomatous polyp M-8210/3 Adenocarcinoma in adenomatous polyp M-8211/0 Tubular adenoma, NOS M-8211/3 Tubular adenocarcinoma M-8212/0 Flat adenoma M-8213/0 Serrated adenoma (C18. (wolfbane.com)
  • M-8401/0 Apocrine adenoma M-8401/3 Apocrine adenocarcinoma M-8402/0 Nodular hidradenoma (C44. (wolfbane.com)
  • Oncocytes (from the greek word swell), also known as Hurthle cells, oxyphilic cells or Askanazy cells, are characterized by abundant granular cytoplasm due to aberrant accumulation of mitochondria. (atlasgeneticsoncology.org)
  • Other terms for the Hurthle cells include oncocytic, eosinophilic, and oxyphilic cells. (redorbit.com)
  • G. Paone, G. Treglia, M. Bongiovanni, T. Ruberto, L. Ceriani, L. Giovanella, Incidental detection of Hurthle cell adenoma by 18F-choline PET/CT scan in a patient with prostate cancer. (springer.com)
  • 99m Tc-tetrofosmin dual-phase scintigraphy with early and delayed images was performed and the results supported the presupposition of parathyroid adenoma as shown by increased radiopharmaceutical levels near the lower left thyroid gland on the early image that disappeared on the delayed image. (biomedcentral.com)
  • We herein present a case of a woman with a parathyroid adenoma close to the lower left thyroid gland diagnosed with 99m Tc-tetrofosmin dual-phase scintigraphy. (biomedcentral.com)
  • A subtype of follicular adenoma in the THYROID GLAND. (bvsalud.org)
  • Water-clear cell adenoma (WCCA) of the parathyroid gland is an exceedingly rare neoplasm. (hindawi.com)
  • The aim: To assess the impact of elective central lymph node dissection on postoperative pathological staging and early surgical complication rate in patients operated for suspicion for follicular neoplasm or suspicion for oxyphilic neoplasm of thyroid. (bvsalud.org)
  • There are no reliable cytologic features which distinguish oncocytic adenomas from carcinomas and the only criterion for a diagnosis of malignancy is the identification of transcapsular or vascular invasion. (wikipedia.org)
  • The histologic differential diagnosis includes syringocystadenoma papilliferum and tubular apocrine adenoma. (oncologynurseadvisor.com)
  • The mean age at diagnosis was 43 years for adenomas and 52 for oncocytic carcinomas in a recent series. (atlasgeneticsoncology.org)
  • This case report presents the significance and practicality of 99m Tc-tetrofosmin for the diagnosis of parathyroid adenomas with probable high p-glycoprotein levels. (biomedcentral.com)
  • We strongly recommend the use of reverse 99m Tc-tetrofosmin scintigraphy as a useful and safe examination technique for the diagnosis of parathyroid adenomas. (biomedcentral.com)
  • At present, preoperative discrimination between follicular adenoma and follicular cancer is infeasible and most patients require surgery to confirm diagnosis. (bvsalud.org)
  • New tools must be developed to improve preoperative diagnosis and deferral of surgery in cases of adenomas. (scielo.br)
  • Serum levels of parathyroid hormone (PTH), alkaline phosphatase (ALP), calcium, creatinine, and vitamin D and the glomerular filtration rate were compared with the histologic properties and expression of PTH and chromogranin A in excised parathyroid adenomas from patients with primary hyperparathyroidism (pHPT). (lu.se)
  • Parathyroid chief cell adenoma associated with massive chronic parathyroiditis in a woman with hyperparathyroidism. (semanticscholar.org)
  • Localisation of parathyroid adenomas reduces operating time and perioperative morbidity following parathyroidectomy. (bmj.com)
  • There is a female preponderance in both subgroups, with a female-to-male ratio of 8:1 in adenomas and 2:1 in carcinomas. (atlasgeneticsoncology.org)
  • Conversely, adenomas are considerably larger, and have a mean mass of more than 10 times the normal parathyroid gland, they are thus often identified during cross-sectional imaging. (biomedcentral.com)
  • A parathyroid gland adenoma composed predominantly of neoplastic chief cells. (semanticscholar.org)
  • Three cases of MTC, Hürthle cell adenoma and papillary thyroid cancer are reported with preoperative scintigraphy, T/B ratios and Northern analyses of the surgical biopsies. (gu.se)
  • Few studies have assessed the ability of preoperative characteristics in differentiating HCCs from Hürthle cell adenomas (HCAs) due to the low prevalence of both lesions. (scielo.br)
  • Water-clear cell hyperplasia (WCCH) and water-clear cell adenoma (WCCA) are rare entities [ 1 , 2 ], with the first case of WCCH being published in 1934 by Albright et al. (hindawi.com)
  • Tc-sestamibi is the most frequently used radionuclide agent for the detection of parathyroid adenomas in the clinical setting. (biomedcentral.com)
  • The most common benign lesion was follicular adenoma diagnosed in 42 (60%) patients. (bvsalud.org)
  • nonfunctional adenoma ( nonfunctioning adenoma ) endocrine-inactive adenoma . (thefreedictionary.com)
  • Most adrenocortical adenomas are nonfunctional. (bireme.br)
  • Adenoma, Islet Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • On electron microscopy, the cytoplasm of the oxyphilic cells is packed with mitochondria. (health.am)
  • see prolactinoma , corticotroph adenoma , gonadotroph adenoma , growth hormone-secreting adenoma , and thyrotroph adenoma . (thefreedictionary.com)