Growth Hormone-Secreting Pituitary Adenoma
ACTH-Secreting Pituitary Adenoma
Expression of somatostatin receptors in oncocytic (Hurthle cell) neoplasia of the thyroid. (1/183)Ten consecutive patients with Hurthle cell lesions of the thyroid (nodule/adenoma/carcinoma) were studied by (111)In-DTPA-D-Phe1-octreotide scintigraphy. Octreotide scintigraphy localized the primary Hurthle cell tumour in eight patients as distinct areas of increased uptake of radionuclide. Two patients with Hurthle cell carcinoma, previously thyroidectomized, had their metastases visualized by octreotide scintigraphy. Northern analyses showed expression of multiple somatostain receptor subtypes. Visualization of the Hurthle cell tumour may be due to a higher expression of somatostatin receptors in the lesions than in surrounding normal thyroid tissue. The tissue/blood (111)In concentration ratios for tumour samples from five patients showed clearly higher values than observed for normal connective tissue, muscle or lymph nodes. A relatively high uptake of (111)In was also observed in goiter tissue, which may lead to misinterpretations. The main indication for octreotide scintigraphy in patients with Hurthle cell carcinoma is suspicion of metastatic disease. (+info)
Adrenocortical oncocytoma. (2/183)The histopathology and ultrastructural features of an adrenocortical oncocytoma are reported. The tumour was discovered incidentally during investigation for hypertension in a 72 year old female. Oncocytic tumours of the adrenal cortex are rare, with only 20 examples described in English language reports. Most have been non-functioning and benign, like the present example. Molecular studies may help assess the significance of oncocytic change in the pathogenesis and behaviour of oncocytic neoplasms. (+info)
Pathologic features, proliferative activity, and cyclin D1 expression in Hurthle cell neoplasms of the thyroid. (3/183)Making a histologic distinction between Hurthle cell adenomas and carcinomas sometimes may be difficult. We analyzed a series of Hurthle cell lesions to determine whether specific histologic features and expression of Ki67 and cyclin D1 could be useful in distinguishing Hurthle cell adenomas from carcinomas. Formalin-fixed, paraffin-embedded tissues from 128 Hurthle cell neoplasms, including 59 adenomas; 55 carcinomas; and 14 tumors classified as neoplasms of uncertain malignant behavior (UMB), which had equivocal capsular invasion but no vascular invasion, were analyzed for expression of Ki67 and cyclin D1 by immunostaining. The distribution of immunoreactivity for Ki67 with antibody MIB-1 was analyzed by quantifying the percentage of positive nuclei that was expressed as the labeling index. None of the patients with adenomas or UMB tumors developed recurrent or metastatic disease after a mean follow-up of 7.8 and 7.9 years, respectively. Of the 55 patients with Hurthle cell carcinoma, 19 were associated with metastatic disease, 13 of whom died with disease. No patient with a Hurthle cell carcinoma without vascular invasion developed metastatic disease. The mean tumor size for Hurthle cell carcinomas (4.8 cm) was significantly larger than that of Hurthle cell adenomas (3.1 cm) or UMB tumors (3.7 cm). No patient with a Hurthle cell tumor smaller than 3.5 cm developed metastatic disease, even when vascular invasion was present. The Ki67 labeling index in Hurthle cell carcinomas (10.0 +/- 1.2) was 3-fold higher than in Hurthle cell adenomas (3.2 +/- 0.3). The Ki67 labeling index in the UMB group was 5.0 +/- 0.7. Cyclin D1 showed diffuse nuclear staining in 1 of the 59 (1.7%) Hurthle cell adenomas, in 10 of the 55 (18%) Hurthle cell carcinomas, and in none of the UMB tumors. In summary, analyses of the cell cycle proteins Ki67 and cyclin D1 in Hurthle cell thyroid neoplasms indicate that these markers may assist in distinguishing some Hurthle cell carcinomas from adenomas. Among the Hurthle cell carcinomas, large tumor size and vascular invasion are associated with clinically aggressive tumors. Our study also suggests that Hurthle cell neoplasms with only equivocal capsular invasion and no vascular invasion should behave in a benign manner. (+info)
Bilateral renal oncocytoma in a Greyhound dog. (4/183)A bilateral, locally invasive renal oncocytoma was diagnosed in a 10-year-old spayed female Greyhound dog. The diagnosis was based on positive staining of the tumor with the periodic acid-Schiff reaction prior to diastase treatment, on the immunohistochemical expression of cytoplasmic cytokeratin, and on the prominence of mitochondria in the tumor cells. (+info)
VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation. (5/183)To elucidate the role of somatic alterations for renal cancer etiology and prognosis, we analyzed 227 sporadic renal epithelial tumors for mutations and hypermethylations in the von Hippel-Lindau tumor suppressor gene VHL. Tumors were classified according to the recommendations of the Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC). Somatic VHL mutations were identified by PCR, single-strand conformation polymorphism analysis, and sequencing, and hypermethylations were identified by restriction enzyme digestion and Southern blotting. Frequencies of VHL alterations were established, and an association with tumor type or tumor type and tumor stage was evaluated. VHL mutations and hypermethylations were identified in 45% of clear cell renal cell carcinomas (CCRCCs) and occasionally (3 of 28) in papillary (chromophilic) renal cell carcinomas (RCCs). Lack of VHL mutations and hypermethylations in chromophobe RCCs and oncocytomas was statistically significant (P = 0.0001 and P = 0.0004, respectively). RCCs carrying VHL alterations showed, in nine cases (12%), mutations at a hot spot involving a thymine repeat (ATT.TTT) in exon 2. Tumor staging was critical to the VHL mutation/hypermethylation detection rate in CCRCCs shown by separate evaluation of patients from medical centers in Munich, Heidelberg, and Mainz. The spectrum of pT1, pT2, and pT3 CCRCCs and the VHL mutation/hypermethylation detection rate varied among these three groups. Altogether, VHL alterations were significantly associated with pT3 CCRCCs (P = 0.009). This is the first evidence of frequent somatic VHL mutations at a particular site within exon 2 and an association of VHL mutations/hypermethylations with a standard prognostic factor. (+info)
Hurthle cell adenoma diagnosed by core needle biopsy in a male patient. (6/183)Hurthle cell adenomas (HCAs) are a rare and potentially lethal variant of follicular tumors of the thyroid. Considerable controversy exists regarding potential risk factors, diagnosis, and treatment of HCAs. The authors report the case of a 38-year-old male patient with an 8.3 cm x 3.5 cm HCA. Diagnosis was made preoperatively from a core needle biopsy and confirmed postoperatively on frozen section. Treatment consisted of a right lobectomy. (+info)
Immunohistochemical and ultrastructural study of clinically nonfunctioning pituitary adenomas. (7/183)Sixty-five clinically nonfunctioning pituitary adenomas were studied by immunohistochemistry, and 12 cases were also analyzed by electron microscopy. Thirty-nine cases (60%) were immunohistochemically identified as hormone-producing adenomas. Six adenomas produced multiple hormones. Electron microscopy found seven null cell adenomas and five oncocytomas. The oncocytomas had a significantly higher incidence of hormone expression that the null cell adenomas. These results indicate that clinically nonfunctioning pituitary adenomas produce hormones, even though blood hormone levels are normal or low. Furthermore, the evidence of multihormonal production implies that two or more cell lineages including a protein hormone-producing type and a glycoprotein hormone-producing type may exist in the same nonfunctioning pituitary adenoma. (+info)
Bronchial oncocytoma. (8/183)CONTEXT: Oncocytomas are generally small and present slow growth. Finding of the tumor usually occurs incidentally. Their incidence is higher among male patients. Oncocytomas in mucous bronchial glands are extremely rare. CASE REPORT: A 35-year-old male who presented bronchial oncocytoma. The tumor was found after bronchoscopy that investigated an atelectasis of the upper left lobe. Histological examination with optical microscopy revealed a mature neoplasm formed by ovoid cells with thin, granular, eosinophilic cytoplasm and small nuclei similar to oncocytes. Electron microscopy showed mitochondrial hyperplasia. A three-year follow-up after thoracotomy followed by lobectomy and removal of the bronchial tumor was uneventful. (+info)
Adenoma, oxyphilic is a type of benign (non-cancerous) tumor that develops in the thyroid gland. It is also known as a "Hürthle cell adenoma" or "oncocytic adenoma." The tumor is composed of cells that are larger and more abundant in mitochondria (organelles responsible for energy production) than normal thyroid cells. This gives the tumor a distinctive appearance under a microscope, with a granular or "oncocytic" cytoplasm. While adenoma, oxyphilic is usually benign, it can sometimes produce excessive amounts of thyroid hormones, leading to symptoms such as weight loss, rapid heartbeat, and anxiety. In some cases, the tumor may also compress nearby structures, causing symptoms such as difficulty swallowing or hoarseness. Treatment for adenoma, oxyphilic typically involves surgical removal of the tumor. In some cases, medication may be used to manage symptoms or reduce the risk of complications.
An adenoma is a benign (non-cancerous) tumor that develops from glandular cells. It is a type of neoplasm, which is an abnormal growth of cells. Adenomas can occur in various parts of the body, including the colon, rectum, breast, thyroid gland, and prostate gland. In the colon and rectum, adenomas are commonly referred to as polyps. They can vary in size and shape and may or may not cause symptoms. However, some adenomas can develop into cancer if left untreated, which is why they are often removed during a colonoscopy or other screening tests. In other parts of the body, adenomas may cause symptoms depending on their location and size. For example, an adenoma in the thyroid gland may cause a goiter, while an adenoma in the prostate gland may cause difficulty urinating. Treatment for adenomas depends on their size, location, and whether they are causing symptoms. Small adenomas may not require treatment, while larger ones may be removed through surgery or other procedures. In some cases, medication may be used to shrink the adenoma or prevent it from growing back.
Thyroid neoplasms refer to abnormal growths or tumors in the thyroid gland, which is a butterfly-shaped gland located in the neck. These neoplasms can be either benign (non-cancerous) or malignant (cancerous). Thyroid neoplasms can occur in any part of the thyroid gland, but some areas are more prone to developing tumors than others. The most common type of thyroid neoplasm is a thyroid adenoma, which is a benign tumor that arises from the follicular cells of the thyroid gland. Other types of thyroid neoplasms include papillary thyroid carcinoma, follicular thyroid carcinoma, medullary thyroid carcinoma, and anaplastic thyroid carcinoma. Thyroid neoplasms can cause a variety of symptoms, depending on the size and location of the tumor, as well as whether it is benign or malignant. Some common symptoms include a lump or swelling in the neck, difficulty swallowing, hoarseness, and a rapid or irregular heartbeat. Diagnosis of thyroid neoplasms typically involves a combination of physical examination, imaging studies such as ultrasound or CT scan, and biopsy of the thyroid tissue. Treatment options for thyroid neoplasms depend on the type, size, and location of the tumor, as well as the patient's overall health and age. Treatment may include surgery, radiation therapy, or medication to manage symptoms or slow the growth of the tumor.
Adenoma, Pleomorphic is a type of benign (non-cancerous) tumor that arises from the cells of the pleomorphic adenoma, which is a type of glandular tissue found in various parts of the body. Pleomorphic adenomas are most commonly found in the salivary glands, but they can also occur in other glands, such as the thyroid gland and the breast. Pleomorphic adenomas are usually slow-growing and may not cause any symptoms. However, in some cases, they can grow large enough to cause problems, such as swelling or difficulty swallowing. They may also become cancerous, although this is rare. Treatment for pleomorphic adenomas typically involves surgical removal of the tumor. In some cases, radiation therapy may also be used to shrink the tumor or prevent it from growing back.
Adenoma, Villous is a type of non-cancerous growth (benign tumor) that occurs in the lining of the colon or rectum. It is characterized by the presence of villi, which are finger-like projections that line the inner surface of the lining of the colon or rectum. These villi are covered in cells that produce mucus and other substances that help to protect the lining of the colon or rectum. Villous adenomas are usually small and may not cause any symptoms. However, in some cases, they can grow larger and cause problems such as bleeding, blockage of the colon or rectum, or the development of cancer. They are typically diagnosed through colonoscopy, a procedure in which a flexible tube with a camera on the end is inserted into the colon or rectum to examine the lining. Treatment for villous adenomas may include the removal of the growth through a procedure called polypectomy, in which the growth is removed using a snare or other tool. In some cases, if the growth is large or has certain characteristics, surgery may be necessary to remove the affected area of the colon or rectum. It is important to note that while villous adenomas are usually non-cancerous, they can sometimes develop into cancer, so it is important to have them monitored and treated if necessary.
Pituitary neoplasms are tumors that develop in the pituitary gland, a small endocrine gland located at the base of the brain. The pituitary gland is responsible for producing and regulating various hormones in the body, and when a tumor develops, it can disrupt the normal functioning of the gland and lead to a variety of symptoms. There are several types of pituitary neoplasms, including: 1. Pituitary adenomas: These are the most common type of pituitary neoplasm and are usually benign (non-cancerous). They can produce excessive amounts of hormones, leading to symptoms such as headaches, vision problems, and hormonal imbalances. 2. Pituitary carcinomas: These are rare and aggressive forms of pituitary neoplasms that can spread to other parts of the body. 3. Pituitary macroadenomas: These are larger tumors that can cause symptoms such as hormonal imbalances, headaches, and vision problems. 4. Pituitary microadenomas: These are smaller tumors that may not cause any symptoms, but can still be detected through imaging tests. Treatment for pituitary neoplasms may include surgery, radiation therapy, and medication to manage symptoms and hormone levels. The specific treatment approach will depend on the type and size of the tumor, as well as the patient's overall health and symptoms.
An adrenocortical adenoma is a benign (non-cancerous) tumor that develops in the adrenal cortex, which is the outer layer of the adrenal gland. The adrenal gland is located on top of each kidney and is responsible for producing hormones such as cortisol, aldosterone, and androgens. Adrenocortical adenomas can cause an overproduction of these hormones, leading to a condition called Cushing's syndrome in women and virilization (masculinization) in men. Symptoms of Cushing's syndrome may include weight gain, particularly in the face and upper body, thinning skin that bruises easily, muscle weakness, and high blood pressure. Symptoms of virilization may include deepening of the voice, growth of facial hair, and breast shrinkage in women. Adrenocortical adenomas are typically diagnosed through imaging tests such as CT scans or MRIs, and confirmed through a biopsy. Treatment options may include surgery to remove the tumor, radiation therapy, or medications to control hormone production.
Adenoma, Liver Cell is a benign (non-cancerous) tumor that develops in the liver cells. It is also known as a hepatocellular adenoma or HCA. These tumors are usually small, ranging in size from a few millimeters to several centimeters, but in rare cases, they can grow larger and cause symptoms such as abdominal pain, nausea, and vomiting. Adenomas are more common in women than men and are often associated with hormonal imbalances, such as those seen in women taking oral contraceptives or women with polycystic ovary syndrome (PCOS). They can also occur in people with certain genetic conditions, such as hereditary nonpolyposis colorectal cancer (HNPCC) or familial adenomatous polyposis (FAP). While most adenomas are benign and do not cause any problems, there is a small risk of them developing into liver cancer. Therefore, they are usually removed surgically if they are large or if there are concerns about their potential to become cancerous. In some cases, liver transplantation may be necessary if the adenoma is causing significant symptoms or if it is affecting the liver's ability to function properly.
Adenoma, Chromophobe is a type of benign (non-cancerous) tumor that develops in the adrenal gland. It is characterized by the absence of pigmentation, which is why it is called "chromophobe." Adenomas are usually small and grow slowly, and they are often discovered incidentally during imaging studies for other conditions. They can cause hormonal imbalances, such as high blood pressure or diabetes, if they produce excess hormones. Treatment for adenomas, chromophobe is usually surgical removal, although in some cases, medication may be used to control hormone production. The prognosis for people with adenomas, chromophobe is generally good, as they are not cancerous and do not spread to other parts of the body.
Growth Hormone-Secreting Pituitary Adenoma, also known as acromegaly, is a rare hormonal disorder that occurs when the pituitary gland produces excessive amounts of growth hormone (GH). The pituitary gland is a small gland located at the base of the brain that produces hormones that regulate various bodily functions, including growth and development. In individuals with acromegaly, the excess GH causes the bones and soft tissues to grow abnormally, leading to a variety of physical and health problems. Common symptoms of acromegaly include enlargement of the hands and feet, thickening of the skin, joint pain, and excessive sweating. The condition can also lead to other health problems, such as diabetes, high blood pressure, and sleep apnea. Treatment for acromegaly typically involves surgery to remove the pituitary adenoma, followed by medication to control GH production. In some cases, radiation therapy may also be used to shrink the tumor. Early diagnosis and treatment are important to prevent complications and improve outcomes for individuals with acromegaly.
Colorectal neoplasms refer to abnormal growths or tumors that develop in the colon or rectum. These growths can be either benign (non-cancerous) or malignant (cancerous). Colorectal neoplasms can be further classified into polyps, adenomas, and carcinomas. Polyps are non-cancerous growths that typically arise from the inner lining of the colon or rectum. Adenomas are a type of polyp that have the potential to become cancerous if left untreated. Carcinomas, on the other hand, are cancerous tumors that can invade nearby tissues and spread to other parts of the body. Colorectal neoplasms are a common health concern, and regular screening is recommended for individuals at high risk, such as those with a family history of colorectal cancer or those over the age of 50. Early detection and treatment of colorectal neoplasms can significantly improve outcomes and reduce the risk of complications.
Colonic polyps are small growths that develop on the inner lining of the colon. They are usually benign, meaning they are not cancerous, but in some cases, they can develop into cancer if left untreated. Colonic polyps can be classified into different types based on their size, number, and appearance. Some common types of colonic polyps include: 1. Adenomatous polyps: These are the most common type of colonic polyps and are usually caused by a genetic predisposition. They can develop into cancer if left untreated. 2. Hyperplastic polyps: These polyps are not usually cancerous and are often found in people over the age of 50. 3. Villous adenomas: These polyps are similar to adenomatous polyps but have a villous appearance, meaning they have finger-like projections. 4. Tubular adenomas: These polyps are also similar to adenomatous polyps but have a tubular appearance. Colonic polyps are usually detected during a colonoscopy, which is a procedure that involves inserting a flexible tube with a camera into the colon to examine the lining of the colon. If a polyp is found, it can be removed during the colonoscopy. Regular screening for colonic polyps is recommended for people over the age of 50, especially those with a family history of colon cancer or other risk factors.
An ACTH-secreting pituitary adenoma is a type of benign tumor that develops in the pituitary gland, a small endocrine gland located at the base of the brain. This type of adenoma produces excess amounts of adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands to produce cortisol, a hormone that regulates metabolism and the body's response to stress. The overproduction of cortisol in individuals with an ACTH-secreting pituitary adenoma can lead to a variety of symptoms, including weight gain, high blood pressure, muscle weakness, fatigue, and mood changes. In some cases, the excess cortisol production can also cause the skin to become thin and fragile, and the bones to become weak and brittle. Treatment for an ACTH-secreting pituitary adenoma typically involves surgery to remove the tumor, followed by medication to manage any remaining symptoms or to prevent the tumor from growing back. In some cases, radiation therapy may also be used to treat the tumor.
Adenoma, Acidophil is a type of benign (non-cancerous) tumor that develops in the glands of the digestive system, particularly in the stomach. It is characterized by the presence of acid-secreting cells, which are responsible for producing hydrochloric acid in the stomach. Acidophilic adenomas are typically small and asymptomatic, meaning they do not cause any noticeable symptoms. However, in some cases, they can grow larger and cause problems such as stomach pain, nausea, vomiting, and difficulty swallowing. Treatment for acidophilic adenomas usually involves surgical removal, although in some cases, they may be monitored with regular endoscopy to ensure they do not grow or cause any complications.
Colonoscopy is a medical procedure that involves using a flexible, lighted tube called a colonoscope to examine the inside of the colon and rectum. The colonoscope is inserted through the anus and advanced into the colon, allowing the doctor to view the lining of the colon and any abnormalities that may be present. During a colonoscopy, the doctor may also take biopsies of any abnormal tissue or remove polyps (small growths on the lining of the colon) that are found. The procedure is typically performed under sedation to help the patient relax and tolerate the procedure more comfortably. Colonoscopy is an important screening tool for colon cancer, as it allows doctors to detect and remove precancerous polyps before they have a chance to develop into cancer. It is also used to diagnose and treat a variety of other conditions, such as inflammatory bowel disease, diverticulitis, and colitis.
Adenomatous polyps are non-cancerous growths that develop in the lining of the colon or rectum. They are usually small, but can grow larger over time. Adenomatous polyps are considered to be precursors to colon cancer, as they can develop into cancerous tumors if left untreated. They are typically found during a colonoscopy, a procedure in which a flexible tube with a camera is inserted into the colon to examine the lining for any abnormalities. If adenomatous polyps are found, they can be removed during the colonoscopy to prevent the development of cancer.
A prolactinoma is a benign (non-cancerous) tumor that develops in the pituitary gland, which is a small gland located at the base of the brain. The pituitary gland produces several hormones, including prolactin, which is responsible for stimulating milk production in the breasts of women who are breastfeeding or pregnant. Prolactinomas are the most common type of pituitary tumor, accounting for about 40% of all pituitary tumors. They are usually slow-growing and do not spread to other parts of the body. However, they can cause a variety of symptoms, depending on their size and location. The main symptom of a prolactinoma is an overproduction of prolactin, which can cause irregular menstrual periods, infertility, and breast milk production in women who are not pregnant or breastfeeding. In men, an overproduction of prolactin can cause erectile dysfunction, decreased libido, and infertility. Treatment for prolactinomas typically involves medication to lower prolactin levels and shrink the tumor. In some cases, surgery or radiation therapy may be necessary if the tumor is large or causing severe symptoms.
Adenoma, Basophil is a type of benign (non-cancerous) tumor that arises from the cells of the endocrine glands. It is characterized by the presence of basophilic cells, which are cells that contain large amounts of a pigment called basophilic granules. Basophilic adenomas are typically small and slow-growing, and they may occur in a variety of endocrine glands, including the thyroid gland, the parathyroid gland, and the adrenal gland. They are usually asymptomatic, meaning that they do not cause any symptoms, and they are often discovered incidentally during imaging studies for other conditions. Treatment for basophilic adenomas typically involves surgical removal of the tumor. In some cases, medication may be used to manage symptoms or to shrink the tumor before surgery. Overall, basophilic adenomas are considered to be relatively benign and are not typically associated with an increased risk of cancer.
Adrenal cortex neoplasms, also known as adrenal cortical tumors, are abnormal growths that develop in the outer layer of the adrenal gland, which is called the cortex. The adrenal cortex is responsible for producing hormones such as cortisol, aldosterone, and androgens, which play important roles in regulating various bodily functions. There are two main types of adrenal cortex neoplasms: benign and malignant. Benign tumors are non-cancerous and do not spread to other parts of the body. Malignant tumors, on the other hand, are cancerous and can invade nearby tissues and spread to other parts of the body through the bloodstream or lymphatic system. Symptoms of adrenal cortex neoplasms may include weight loss, fatigue, high blood pressure, and an increase in the production of certain hormones, such as cortisol or aldosterone. Diagnosis typically involves imaging tests such as CT scans or MRIs, as well as blood and urine tests to measure hormone levels. Treatment for adrenal cortex neoplasms depends on the type and size of the tumor, as well as the patient's overall health. Benign tumors may be monitored with regular imaging tests, while malignant tumors may require surgery, radiation therapy, or chemotherapy. In some cases, hormone therapy may also be used to manage symptoms or slow the growth of the tumor.
Adenomatous Polyposis Coli (APC) is a genetic disorder that affects the colon and rectum. It is characterized by the development of numerous benign growths, or polyps, in the lining of the colon and rectum. These polyps can develop into cancer if left untreated. APC is caused by mutations in the APC gene, which is responsible for regulating cell growth and division. The disorder is inherited in an autosomal dominant pattern, meaning that an affected individual has a 50% chance of passing the mutated gene to each of their children. Symptoms of APC may include rectal bleeding, changes in bowel habits, abdominal pain, and unexplained weight loss. Diagnosis is typically made through colonoscopy, where biopsies of the polyps are taken for analysis. Treatment for APC may include surgery to remove polyps or the entire colon and rectum, as well as chemotherapy and radiation therapy to treat any cancer that has developed. Lifestyle changes, such as a healthy diet and regular exercise, may also help to reduce the risk of developing cancer.
International Classification of Diseases for Oncology
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Chief cell - Wikipedia
Parathyroid Physiology: Calcium Homeostasis, Disorders of Parathyroid Hormone Metabolism, Pathophysiology
Thyroid Cancer: Practice Essentials, Etiology, Epidemiology
Neoplasm staging. Medical search. Definitions
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College of Allied Health Sciences - Scholarly Output - Augusta University Research Profiles
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- Approximately 85% of cases are found to be caused by an isolated parathyroid adenoma, 15% by diffuse parathyroid hyperplasia, and less than 1% by parathyroid carcinoma. (medscape.com)
- therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)
- According to the World Health Organization (WHO), these neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type. (medscape.com)
- We touched on the issue that follicular carcinoma cannot be distinguished from follicular adenoma by aspiration, and so if that quandary remains, in general I will recommend surgery to the patient. (cancerstreatment.com)
- But occasionally one will see neoplasms which consist predominantly of oxyphilic cells with sort of a granular cytoplasm and this defines the Hurthle cell variant . (cancerstreatment.com)
- [ 4 ] in a series of 23 patients, the mean tumor size was significantly greater for carcinomas than adenomas (3.1 cm vs 1.9 cm). (medscape.com)
Chief cell parathyroid1
- 1. Molecular profiles of oxyphilic and chief cell parathyroid adenoma. (nih.gov)
- A subtype of follicular adenoma in the THYROID GLAND. (bvsalud.org)