Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Legislation, Food: Laws and regulations concerned with industrial processing and marketing of foods.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Job Application: Process of applying for employment. It includes written application for employment or personal appearance.Neuroendocrine Tumors: Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.Carcinoma, Neuroendocrine: A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)Carcinoma, Islet Cell: A primary malignant neoplasm of the pancreatic ISLET CELLS. Usually it involves the non-INSULIN-producing cell types, the PANCREATIC ALPHA CELLS and the pancreatic delta cells (SOMATOSTATIN-SECRETING CELLS) in GLUCAGONOMA and SOMATOSTATINOMA, respectively.Carcinoid Tumor: A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Somatostatinoma: A SOMATOSTATIN-secreting tumor derived from the pancreatic delta cells (SOMATOSTATIN-SECRETING CELLS). It is also found in the INTESTINE. Somatostatinomas are associated with DIABETES MELLITUS; CHOLELITHIASIS; STEATORRHEA; and HYPOCHLORHYDRIA. The majority of somatostatinomas have the potential for METASTASIS.Adenoma, Islet Cell: A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM.Octreotide: A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.Islets of Langerhans: Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Adenoma: A benign epithelial tumor with a glandular organization.Congenital Hyperinsulinism: A familial, nontransient HYPOGLYCEMIA with defects in negative feedback of GLUCOSE-regulated INSULIN release. Clinical phenotypes include HYPOGLYCEMIA; HYPERINSULINEMIA; SEIZURES; COMA; and often large BIRTH WEIGHT. Several sub-types exist with the most common, type 1, associated with mutations on an ATP-BINDING CASSETTE TRANSPORTERS (subfamily C, member 8).Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.Hyperinsulinism: A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.Nesidioblastosis: An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and CONGENITAL HYPERINSULINISM. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11.Adenoma, Liver Cell: A benign epithelial tumor of the LIVER.PhiladelphiaPituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.Infant, Newborn: An infant during the first month after birth.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Dictionaries, ChemicalTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)Growth Hormone-Secreting Pituitary Adenoma: A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.Human Growth Hormone: A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.Growth Hormone: A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.Sphenoid Bone: An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).Pituitary Gland: A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.Pituitary Gland, Anterior: The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.Prolactinoma: A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.
(1/311) Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms.

Endocrine pancreatic tumors (EPT) and neuroendocrine tumors (NET) occur sporadically and rarely in association with multiple endocrine neoplasia type 1 (MEN1). We analyzed the frequency of allelic deletions and mutations of the recently identified MEN1 gene in 53 sporadic tumors including 30 EPT and 23 NET (carcinoids) of different locations and types. Allelic deletion of the MEN1 locus was identified in 18/49 (36.7%) tumors (13/30, 43.3% in EPT and 5/19, 26.3% in NET) and mutations of the MEN1 gene were present in 8/52 (15.3%) tumors (4/30 (13.3%) EPT and 4/22 (18.1%) NET). The somatic mutations were clustered in the 5' region of the coding sequence and most frequently encompassed missense mutations. All tumors with mutations exhibited a loss of the other allele and a wild-type sequence of the MEN1 gene in nontumorous DNA. In one additional patient with a NET of the lung and no clinical signs or history of MEN1, a 5178-9G-->A splice donor site mutation in intron 4 was identified in both the tumor and blood DNA, indicating the presence of a thus far unknown MEN1 syndrome. In most tumor groups the frequency of allelic deletions at 11q13 was 2 to 3 times higher than the frequency of identified MEN1 gene mutations. Some tumor types, including rare forms of EPT and NET of the duodenum and small intestine, exhibited mutations more frequently than other types. Furthermore, somatic mutations were not restricted to foregut tumors but were also detectable in a midgut tumor (15.2% versus 16.6%). Our data indicate that somatic MEN1 gene mutations contribute to a subset of sporadic EPT and NET, including midgut tumors. Because the frequency of mutations varies significantly among the investigated tumor subgroups and allelic deletions are 2 to 3 times more frequently observed, factors other than MEN1 gene inactivation, including other tumor-suppressor genes on 11q13, may also be involved in the tumorigenesis of these neoplasms.  (+info)

(2/311) Induction of adenocarcinoma from hamster pancreatic islet cells treated with N-nitrosobis(2-oxopropyl)amine in vitro.

Our previous studies in the hamster pancreatic cancer model have indicated that pancreatic ductal adenocarcinomas derive not only from ductal/ductular cells but also from islets. To verify the presence of carcinogen-responsive cells within islets, we tested the effect of the pancreatic carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) on recently established continuous hamster pancreatic islet culture. Isolated pure pancreatic islets of hamsters were treated in vitro with BOP at a concentration of 0.25 mM three times a week for 19 weeks. Each treatment week was designed as a stage. The growth of these cells, designated KL5B, was compared with untreated cultured islets, designated KL5N. As in our previous study, between 14 and 21 days of culture, exocrine and intermediary cells developed within both KL5N and KL5B islets, which were then replaced by undifferentiated cells. No differences were found in the growth patterns of KL5N and KL5B until stage 4, when KL5B cells showed accelerated cell growth and cell pleomorphism, which increased gradually at later stages of treatment. Anchorage-independent and in vivo growth did not appear until stage 19. Mutation of c-Ki-ras at codon 12 (GGT-->GAT) was detected in KL5B cells but not in KL5N cells. In vivo KL5B cells formed anaplastic invasive cancer with areas of glandular formation, overexpressed TGF-alpha and EGFR, expressed cytokeratin, vimentin, laminin and alpha-1 antitrypsin and reacted strongly with L-phytohemagglutinin and tomato lectin. Some cells within islets are responsive to the carcinogenic effects of BOP. Whether these cells represent islet cell precursors (stem cells) or malignant transdifferentiated islet cells remains to be seen.  (+info)

(3/311) Hyperinsulinism: molecular aetiology of focal disease.

Persistent hypoglycaemia in infancy is most commonly caused by hyperinsulinism. A case is reported of the somatic loss of the maternal 11p in an insulin secreting focal adenoma in association with a germline SUR-1 mutation on the paternal allele in a baby boy with hyperinsulinism diagnosed at 49 days old. A reduction to homozygosity of an SUR-1 mutation is proposed as a critical part of the cause of focal hyperinsulinism.  (+info)

(4/311) The hypothalamic satiety peptide CART is expressed in anorectic and non-anorectic pancreatic islet tumors and in the normal islet of Langerhans.

The hypothalamic satiety peptide CART (cocaine and amphetamine regulated transcript) is expressed at high levels in anorectic rat glucagonomas but not in hypoglycemic insulinomas. However, a non-anorectic metastasis derived from the glucagonoma retained high CART expression levels and produced circulating CART levels comparable to that of the anorectic tumors. Moreover, distinct glucagonoma lines derived by stable HES-1 transfection of the insulinoma caused severe anorexia but retained low circulating levels of CART comparable to that of insulinoma bearing or control rats. Islet tumor associated anorexia and circulating CART levels are thus not correlated, and in line with this peripheral administration of CART (5-50 mg/kg) produced no effect on feeding behavior. In the rat two alternatively spliced forms of CART mRNA exist and quantitative PCR revealed expression of both forms in the hypothalamus, in the different islet tumors, and in the islets of Langerhans. Immunocytochemistry as well as in situ hybridization localized CART expression to the somatostatin producing islet D cell. A potential endocrine/paracrine role of islet CART remains to be clarified.  (+info)

(5/311) Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors.

Tumors of the endocrine pancreas are extremely rare, and molecular mechanisms leading to their development are not well understood. A candidate tumor suppressor gene, DPC4, located at 18q21, has recently been shown to be inactivated in half of pancreatic adenocarcinoma xenografts. The close anatomical relationship of the exocrine and endocrine pancreas prompted us to determine the role of DPC4 in the tumorigenesis of 25 pancreatic islet cell tumors (11 insulinomas, nine non-functioning endocrine carcinomas, three gastrinomas, two vipomas). A mutation screening of the highly conserved COOH-terminal domain of DPC4 (exons 8-11) was performed by single-strand conformational variant (SSCP) analysis and a PCR-based deletion assay. Five of nine (55%) non-functioning endocrine pancreatic carcinomas revealed either point mutations, small intragenic deletions or homozygous deletion of DPC4 sequences compared to none of the insulinomas, gastrinomas or vipomas. These results suggest that DPC4 is an important target gene promoting tumorigenesis of non-functioning neuroendocrine pancreatic carcinomas.  (+info)

(6/311) Cellular composition and anatomic distribution in nonfunctioning pancreatic endocrine tumors: immunohistochemical study of 30 cases.

OBJECTIVE: To investigate the cytological pattern and distribution in nonfunctioning pancreatic endocrine tumors. METHODS: Using labeled streptavidin-biotin (LSAB), immunohistochemical staining for insulin, glucagon, somatostatin, pancreatic polypeptide and gastrin was performed on 30 nonfunctioning pancreatic endocrine tumors from 30 patients. The cellular composition and anatomic distribution in these tumors were analyzed. RESULTS: Of 30 tumor tissues, 22 (73.3%) were found to contain cells immunoreactive to 1-4 kinds of peptide hormones; 17 (56.7%) showed positive staining for more than one peptide and up to 4 peptides; and 8 (26.7%) showed negative immunoreaction to all antiserum applied. No tumor was found to contain immunoreactive gastrin. Among 17 multihormonal tumors, 4 contained 2 kinds of peptide hormones, 8 had 3 kinds, and 5 harbored 4 kinds of peptide hormones. In addition, the difference in the number and type of positive endocrine cells between the tumors arising from the head of the pancreas and those arising from the body and tail of the pancreas were statistically significant (P < 0.05). CONCLUSIONS: Immunohistochemically, the high positive rate to peptide hormones suggests that the nonfunctioning pancreatic endocrine tumors are actually not nonfunctioning; they are asymptomatic pancreatic endocrine tumors. Moreover, an uneven distribution of positive endocrine cells in the nonfunctioning pancreas endocrine tumors within the pancreas was identified.  (+info)

(7/311) Immunohistochemical expression of chromogranins A and B, prohormone convertases 2 and 3, and amidating enzyme in carcinoid tumors and pancreatic endocrine tumors.

Although chromogranin A (CgA) is widely distributed in neuroendocrine tumors, the distribution of chromogranin B (CgB) has not been elucidated. Hormones produced by tumors are sometimes prohormones and not necessarily bioactive hormones. Prohormones have to be processed into bioactive peptides by prohormone convertases (PCs), and some of them have to be amidated by peptidylglycine a-amidating monooxygenase (PGM). Whether PCs and PGM are present or not in tumors may explain why some tumors are functioning and some are nonfunctioning. We investigated 45 carcinoids and 16 pancreatic endocrine tumors. Of the carcinoids, CgA was expressed in most of the tumors, except for the rectal and ovarian carcinoids, which expressed CgB strongly. The expressions of PC2, PC3, and PGM were 31%, 100%, and 87%, respectively. In the pancreatic tumors, CgA was expressed in all tumors, whereas CgB was not expressed in any tumor. The expressions of PC2, PC3, and PGM were 63%, 88%, and 63%, respectively. PC3 was expressed in all of the functioning tumors but not in two of the four nonfunctioning tumors. PC2 and PGM were not expressed in three of the four nonfunctioning tumors. In conclusion, expression of CgA and CgB was different depending on the tumor location. High frequency of PCs and PGM may explain why even nonfunctioning tumors produce some inconspicuous peptides.  (+info)

(8/311) Immunohistochemical localization of betacellulin, a new member of the EGF family, in normal human pancreas and islet tumor cells.

Betacellulin (BTC) purified from mouse beta cell tumor (betaTC-3) is a new member of the epidermal growth factor (EGF) family which can bind receptor tyrosine kinase, EGF receptor (erbB1) and erbB4. It has been demonstrated that proBTC mRNA was abundantly expressed in human pancreas tissue, and that BTC converted amylase-secreting rat acinar cell line (AR42J) into insulin-secreting cells, suggesting that BTC might be important for the growth and/or differentiation of islet cells. However, the cell type producing BTC in the pancreas has not been clarified. In this study, we examined the localization of BTC in human pancreas and islet cell tumors. Immunohistochemistry using specific antibodies to human BTC revealed that this protein was produced in alpha cells and duct cells, and probably in beta cells in normal adult pancreas. Furthermore, strong immunoreactivity to BTC was detected in primitive duct cells of the fetal pancreas, and both insulinoma and glucagonoma cells also showed positive immunoreactivity to BTC. EGF receptor (erbB1) and erbB4 were expressed mainly in islet and duct cells, and duct cells, respectively. These results demonstrate the localization of BTC and its receptors, and suggest that BTC may be one of the factors that have physiologically important roles such as growth and differentiation of islet cells in the human pancreas.  (+info)

*  Pituitary adenoma
It often affects the parathyroid glands, pancreatic islet cells, and anterior lobe of the pituitary gland. MEN1 may also cause ... benign adenoma, invasive adenoma, and carcinomas. Most adenomas are benign, approximately 35% are invasive and just 0.1% to 0.2 ... Pituitary adenomas are tumors that occur in the pituitary gland. Pituitary adenomas are generally divided into three categories ... Various types of headaches are common in patients with pituitary adenomas. The adenoma may be the prime causative factor behind ...
*  Multiple endocrine neoplasia type 1
... diffuse hyperplasia or multiple adenomas are more common than solitary adenomas. Pancreatic islet cell tumors occur in 60 to 70 ... About 60% of islet cell tumors originate from non-β-cell elements and tend to occur in patients > 40 years of age. Non-β-cell ... of islet cell tumors originate from a β-cell, secrete insulin (insulinoma), and can cause fasting hypoglycemia. β-cell tumors ... Multiple adenomas or diffuse islet cell hyperplasia commonly occurs; such tumors may arise from the small bowel rather than the ...
*  Insulinoma
... "islet cell adenoma". Beta cells secrete insulin in response to increases in blood glucose. The resulting increase in insulin ... The first report of a surgical cure of hypoglycemia by removing an islet cell tumour was in 1929. An insulinoma removed from a ... Insulinoma is one of the most common types of tumors arising from the islets of Langerhans cells (pancreatic endocrine tumors ... Streptozotocin is used in islet cell carcinomas which produce excessive insulin. Combination chemotherapy is used, either ...
*  Insulin
"The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma". Proceedings of the National ... Within the pancreatic islets, beta cells constitute 65-80% of all the cells. Insulin consists of two polypeptide chains, the A ... "Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells". The Journal of Biological ... Beta cells in the islets of Langerhans release insulin in two phases. The first-phase release is rapidly triggered in response ...
*  Glyphosate
... and increased pancreatic islet-cell adenoma in male rats. In reproductive toxicity studies performed in rats and rabbits, no ... Workers exposed to glyphosate were about twice as likely to get B cell lymphoma. A 2015 systematic review of observational ... A 2014 review article reported a significant association between B-cell lymphoma and glyphosate occupational exposure. In March ... of the same studies found a correlation between occupational exposure to glyphosate formulations and increased risk of B cell ...
*  Zuclopenthixol
... of mammary adenocarcinomas and of pancreatic islet cell adenomas and carcinomas. An increase in the incidence of mammary ... An increase in the incidence of pancreatic islet cell tumours has been observed for some other D2 antagonists. The ...
*  List of MeSH codes (C19)
... adenoma, islet cell MeSH C19.344.421.249.500 --- insulinoma MeSH C19.344.421.500 --- carcinoma, islet cell MeSH C19.344.421.500 ... growth hormone-secreting pituitary adenoma MeSH C19.344.609.792 --- prolactinoma MeSH C19.344.762.500 --- sertoli-leydig cell ... granulosa cell tumor MeSH C19.344.410.464 --- luteoma MeSH C19.344.410.531 --- meigs syndrome MeSH C19.344.410.648 --- sertoli- ... granulosa cell tumor MeSH C19.391.630.705.464 --- luteoma MeSH C19.391.630.705.531 --- meigs syndrome MeSH C19.391.630.705.648 ...
*  List of MeSH codes (C06)
... adenoma, islet cell MeSH C06.301.761.249.500 --- insulinoma MeSH C06.301.761.500 --- carcinoma, islet cell MeSH C06.301.761.500 ... adenoma, islet cell MeSH C06.689.667.249.500 --- insulinoma MeSH C06.689.667.500 --- carcinoma, islet cell MeSH C06.689.667.500 ... adenoma, liver cell MeSH C06.301.623.160 --- carcinoma, hepatocellular MeSH C06.301.623.460 --- liver neoplasms, experimental ... adenoma, liver cell MeSH C06.552.697.160 --- carcinoma, hepatocellular MeSH C06.552.697.580 --- liver neoplasms, experimental ...
*  Hyperinsulinemic hypoglycemia
Islet cell adenoma or adenomatosis Islet cell carcinoma Adult nesidioblastosis Autoimmune insulin syndrome Noninsulinoma ... Hyperinsulinism due to diffuse overactivity of beta cells, such as in many of the forms of congenital hyperinsulinism, and more ... Streptozotocin is a specific beta cell toxin and has been used to treat insulin-producing pancreatic carcinoma. ...
*  Penetrance
... a hereditary disorder characterized by parathyroid hyperplasia and pancreatic islet-cell and pituitary adenomas, is caused by a ...
*  Nesidioblastoma
... emphasis that was placed on the observed precise histological recapitulation of normal islet cell structure within the adenomas ... In that report, these lesions were adjudicated as histologically benign adenoma growths, that were associated with severe, long ... Neuroendocrine tumor Laidlaw GF (1938). "Nesidioblastoma, the islet tumor of the pancreas". Am J Pathol. 14 (2): 125-34. PMC ... a more diffuse hyperplasia of the pancreatic beta cells is found, often with an abnormal microscopic appearance. ...
*  List of MeSH codes (C04)
... adenoma, islet cell MeSH C04.557.470.035.100.852 --- insulinoma MeSH C04.557.470.035.120 --- adenoma, liver cell MeSH C04.557. ... adenoma, islet cell MeSH C04.588.274.761.249.500 --- insulinoma MeSH C04.588.274.761.500 --- carcinoma, islet cell MeSH C04.588 ... adenoma, islet cell MeSH C04.588.322.421.249.500 --- insulinoma MeSH C04.588.322.421.500 --- carcinoma, islet cell MeSH C04.588 ... b-cell, acute MeSH C04.557.337.428.500.125 --- leukemia, B-Cell, chronic MeSH C04.557.337.428.500.500 --- leukemia, pre-b-cell ...
*  International Classification of Diseases for Oncology
M8149/0 Canalicular adenoma M8150/0 Islet cell adenoma (C25._) Islet cell tumor, benign Nesidioblastoma Islet cell adeomatosis ... M8550/0 Acinar cell adenoma Acinar adenoma Acinic cell adenoma M8550/1 Acinar cell tumor Acinic cell tumor M8550/3 Acinar cell ... M8150/3 Islet cell carcinoma (C25._) Islet cell adenocarcinoma (M8151/0) Insulinoma, NOS (C25._) Beta cell adenoma M8151/3 ... Oxyphilic adenoma Oncocytic adenoma Oncocytoma Hurthle cell adenoma(C73.9) Hurthle cell tumor Follicular adenoma, oxyphilic ...
*  MEN1
Pancreatic tumours involve the islet cells, giving rise to gastrinomas or insulinomas. In rare cases, adrenal cortex tumours ... MEN1 pituitary tumours are adenomas of anterior cells, typically prolactinomas or growth hormone-secreting. ... cell division, cell proliferation, and genome stability. Insulinomas are neuroendocrine tumors of the pancreas with an ... oftentimes a large deletion occurring in the predisposed endocrine cell and providing cells with the survival advantaged needed ...
*  PAX8
... pancreatic islet cells and lymphoid cells. PAX8 and other transcription factors play a role in binding to DNA and regulating ... nephrogenic adenomas, ovarian cancer cells, bladder, prostate, and endometrial carcinomas. The mechanism of switching on the ... cell polarity and transport, cell motility and adhesion. Expression of PAX8 is increased in neoplastic renal tissues, Wilms ... cell-cycle processes). PAX8 is shown to be involved in tumor cell proliferation and differentiation, signal transduction, ...
*  Maturity onset diabetes of the young
The islet cell autoantibodies are absent in MODY in at least some populations (Japanese, Britons). Persistence of a low insulin ... Liver adenoma or hepatocellular carcinoma in MODY type 3 Renal cysts, rudimentary or bicornuate uterus, vaginal aplasia, ... found that about one quarter of Central European MODY patients are positive for islet cell autoantibodies (GADA and IA2A). ... Urbanova J, Rypackova B, Prochazkova Z, Kucera P, Cerna M, Andel M, Heneberg P (2014). "Positivity for islet cell ...
*  List of diseases (P)
... familial Pancreatic diseases Pancreatic islet cell neoplasm Pancreatic islet cell tumors Pancreatic lipomatosis duodenal ... of Mantoux Palsy cerebral Panayiotopoulos syndrome Pancreas agenesis Pancreas divisum Pancreatic adenoma Pancreatic beta cell ... Peanut hypersensitivity Pearson's marrow/pancreas syndrome Pediatric T-cell leukemia Pediculosis Peeling skin syndrome ... stenosis with Café au lait spot Punctate acrokeratoderma freckle like pigmentation Punctate inner choroidopathy Pure red cell ...
*  Growth hormone
... cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. It is a type ... Eventually, the adenoma may become large enough to cause headaches, impair vision by pressure on the optic nerves, or cause ... liver uptake of glucose Promotes gluconeogenesis in the liver Contributes to the maintenance and function of pancreatic islets ... they cannot penetrate cell membranes. Thus, GH exerts some of its effects by binding to receptors on target cells, where it ...
*  HNF1A
... as well as hepatocellular adenoma. HNF-1 protein is present in clear cell carcinoma of ovary In humans, mutations in HNF1A ... and GLUT2 transporter expression in pancreatic β-cells and angiotensin-converting enzyme 2 gene expression in pancreatic islets ... It has been shown to affect intestinal epithelial cell growth and cell lineages differentiation. For instance, HNF1A is an ... "Hepatocyte Nuclear Factor 1A Is a Cell-Intrinsic Transcription Factor Required for B Cell Differentiation and Development in ...
*  ICD-10 Chapter II: Neoplasms
Endocrine pancreas Islet cell tumour Islets of Langerhans (D13.9) Ill-defined sites within the digestive system Digestive ... Pituitary gland Pituitary adenoma Prolactinoma (D35.3) Craniopharyngeal duct (D35.4) Pineal gland (D35.5) Carotid body (D35.6) ... small cell (diffuse) (C83.1) Small cleaved cell (diffuse) (C83.2) Mixed small and large cell (diffuse) (C83.3) large cell ( ... Leukemia of unspecified cell type (C95.0) Acute leukemia of unspecified cell type (C95.1) Chronic leukemia of unspecified cell ...
*  SCG5
2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... 1988). "Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced ... "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagn Mol Pathol. 3 (1): 38-45. doi:10.1097 ... doi:10.1016/j.cell.2006.03.032. PMID 16713569. Dasgupta I, Sanglas L, Enghild JJ, Lindberg I (2012). "The neuroendocrine ...
*  Stefan R. Bornstein
... stem cell research and advances in islet cell transplantation as a therapy for diabetes. This is why, presently, Dresden is the ... 1998). Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome.. In: N Engl J Med. ... 2012). Isolation, characterization, and differentiation of progenitor cells from human adult adrenal medulla. In: Stem Cells ... In: Cell Metab. doi: 10.1016/j.cmet.2013.04.005 A. Chatzigeorgiou u. a. (2014). Blocking CD40-TRAF6 signaling is a therapeutic ...
*  List of cancer types
... islet cell Rectal cancer Bladder cancer Cervical cancer Endometrial cancer Extragonadal germ cell tumor Ovarian cancer Ovarian ... Bronchial adenomas/carcinoids Small cell lung cancer Mesothelioma Non-small cell lung cancer Pleuropulmonary blastoma Laryngeal ... cell lymphoma Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell ... leukemia Cutaneous T-cell lymphoma Diffuse large B-cell lymphoma Follicular lymphoma Hairy cell leukemia Hepatosplenic T-cell ...
*  Mir-326 microRNA precursor family
"Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells". Neuro- ... "Altered MicroRNA Expression Profile in Human Pituitary GH Adenomas: Down-Regulation of miRNA Targeting HMGA1, HMGA2, and E2F1 ... "Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity". Diabetes/Metabolism ... and miR-326 in the Adipogenic Differentiation Process of Adipose-Derived Stem Cells". OMICS: A Journal of Integrative Biology. ...
*  Secretagogin
This protein is thought to be involved in potassium chloride-stimulated calcium flux and cell proliferation. This protein plays ... and pancreatic islet of Langerhans-specific Ca2+-binding protein". J Biol Chem. 275 (32): 24740-51. doi:10.1074/jbc.M001974200 ... "Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas". Pituitary ...
*  MicroRNA
... and cell cycle in mice lacking miRNA-1-2". Cell. 129 (2): 303-17. doi:10.1016/j.cell.2007.03.030. PMID 17397913. Thum T, ... However, each of these HMGA-targeting miRNAs are drastically reduced in almost all human pituitary adenomas studied, when ... "A pancreatic islet-specific microRNA regulates insulin secretion". Nature. 432 (7014): 226-30. Bibcode:2004Natur.432..226P. doi ... B-cell migration/adhesion, cell-cell interactions in immune niches and the production and class-switching of immunoglobulins. ...
Hyperinsulinism Due to Islet-cell Adenoma | The BMJ  Hyperinsulinism Due to Islet-cell Adenoma | The BMJ
Hyperinsulinism Due to Islet-cell Adenoma Br Med J 1949; 1 :680 ... Hyperinsulinism Due to Islet-cell Adenoma. Br Med J 1949; 1 doi ...
more infohttp://www.bmj.com/content/1/4606/680.2
THE BIOSYNTHESIS OF INSULIN AND A PROBABLE PRECURSOR OF INSULIN BY A HUMAN ISLET CELL ADENOMA | PNAS  THE BIOSYNTHESIS OF INSULIN AND A PROBABLE PRECURSOR OF INSULIN BY A HUMAN ISLET CELL ADENOMA | PNAS
THE BIOSYNTHESIS OF INSULIN AND A PROBABLE PRECURSOR OF INSULIN BY A HUMAN ISLET CELL ADENOMA. Donald F. Steiner and Philip E. ... THE BIOSYNTHESIS OF INSULIN AND A PROBABLE PRECURSOR OF INSULIN BY A HUMAN ISLET CELL ADENOMA ... THE BIOSYNTHESIS OF INSULIN AND A PROBABLE PRECURSOR OF INSULIN BY A HUMAN ISLET CELL ADENOMA ... THE BIOSYNTHESIS OF INSULIN AND A PROBABLE PRECURSOR OF INSULIN BY A HUMAN ISLET CELL ADENOMA ...
more infohttps://www.pnas.org/content/57/2/473
Adenoma, Islet Cell | Profiles RNS  Adenoma, Islet Cell | Profiles RNS
Islet Cell" by people in this website by year, and whether "Adenoma, Islet Cell" was a major or minor topic of these ... "Adenoma, Islet Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical ... Adenoma, Islet Cell*Adenoma, Islet Cell. *Adenomas, Islet Cell. *Islet Cell Adenoma ... Below are the most recent publications written about "Adenoma, Islet Cell" by people in Profiles. ...
more infohttps://profiles.rush.edu/display/25801
A Study Of Sunitinib Compared To Placebo For Patients With Advanced Pancreatic Islet Cell Tumors  A Study Of Sunitinib Compared To Placebo For Patients With Advanced Pancreatic Islet Cell Tumors
This study randomized patients with advanced pancreatic islet cell tumors to receive either sunitinib or placebo. Patients who ... Adenoma, Islet Cell. *Carcinoma, Islet Cell. *Neuroendocrine Tumors. .map{width:100%;height:300px;margin-bottom:15px}. Name. ... Well-differentiated advanced/metastatic pancreatic islet cell tumor. - Tumor has shown progression within the past year.. ... Versus Placebo In Patients With Progressive Advanced/Metastatic Well-Differentiated Pancreatic Islet Cell Tumors. Trial Phase: ...
more infohttp://www.knowcancer.com/cancer-trials/NCT00428597/
Laparoscopy predicts metastatic disease and spares laparotomy in selected patients with pancreatic nonfunctioning islet cell...  Laparoscopy predicts metastatic disease and spares laparotomy in selected patients with pancreatic nonfunctioning islet cell...
Laparoscopy predicts metastatic disease and spares laparotomy in selected patients with pancreatic nonfunctioning islet cell ... Adenoma, Islet Cell (pathology, radiography, surgery) *Humans. *Laparoscopy. *Laparotomy. *Middle Aged. *Neoplasm Metastasis ( ... Laparoscopy predicts metastatic disease and spares laparotomy in selected patients with pancreatic nonfunctioning islet cell ... NFI cell tumors of the pancreas present as large masses with frequent metastases. Despite metastatic disease, prolonged ...
more infohttp://www.curehunter.com/public/pubmed11314942.do
pediatricradiologyflash Flashcards by Scott P | Brainscape  pediatricradiologyflash Flashcards by Scott P | Brainscape
Benign islet cell adenoma (insulinoma). 200 Most common posterior mediastinal mass in a child ... Sickle cell disease. Congenital obstructive anomalies of the biliary tract. Total parenteral nutrition. Furosemide treatment. ... Hepatic adenomas are rare in childhood but have been reported in association with ... Sickle cell disease. Glycogen storage disease. Amyloidosis. Bilateral Wilms' tumor. Acute glomerulonephritis. Acquired immune ...
more infohttps://www.brainscape.com/flashcards/pediatricradiologyflash-3793356/packs/5656497
Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor - Full Text...  Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor - Full Text...
Carcinoma, Merkel Cell. Carcinoma. Neuroendocrine Tumors. Carcinoid Tumor. Pheochromocytoma. Adenoma, Islet Cell. Carcinoma, ... Stage IIIA Merkel Cell Carcinoma Stage IIIB Merkel Cell Carcinoma Stage IV Adrenal Cortex Carcinoma Stage IV Merkel Cell ... Veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy ... Pancreatic neuroendocrine tumors (including functional and non-functional islet cell, insulinomas and glucagonomas) ...
more infohttps://clinicaltrials.gov/ct2/show/NCT02831179?cond=%22Pancreatic+Neuroendocrine+Tumor%22&rank=98
Pazopanib Hydrochloride in Treating Patients With Advanced Neuroendocrine Cancer - Full Text View - ClinicalTrials.gov  Pazopanib Hydrochloride in Treating Patients With Advanced Neuroendocrine Cancer - Full Text View - ClinicalTrials.gov
Neoplasms, Germ Cell and Embryonal. Neoplasms, Nerve Tissue. Adenocarcinoma. Adenoma, Islet Cell. Adenoma. Pancreatic Neoplasms ... Carcinoma, Islet Cell. Multiple Endocrine Neoplasia Type 1. Somatostatinoma. Gastrinoma. Neoplasms, Glandular and Epithelial. ... Patients must have histologically or cytologically confirmed low or intermediate grade carcinoid or islet cell carcinoma; ... Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00454363?recr=Open&cond=%22Carcinoma%2C+Islet+Cell%22&rank=5
Peptide Receptor Radionuclide Therapy (PRRT) With 177Lu-DOTATATE in Advanced Gastro-entero Pancreatic Neuroendocrine Tumors -...  Peptide Receptor Radionuclide Therapy (PRRT) With 177Lu-DOTATATE in Advanced Gastro-entero Pancreatic Neuroendocrine Tumors -...
Adenoma, Islet Cell. Adenoma. Digestive System Diseases. Pancreatic Diseases. Endocrine System Diseases. Octreotide. ... Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. Neoplasms. Neoplasms, Nerve Tissue. Neoplasms, Glandular and ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT02489604?term=somatostatin+analogues&cond=Neuroendocrine+Tumors&rank=11
VEGFR/PDGFR Dual Kinase Inhibitor X-82 and Everolimus for Treating Patients With Pancreatic Neuroendocrine Tumors - Full Text...  VEGFR/PDGFR Dual Kinase Inhibitor X-82 and Everolimus for Treating Patients With Pancreatic Neuroendocrine Tumors - Full Text...
Adenoma, Islet Cell. Carcinoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. Neuroectodermal ... Neoplasms, Germ Cell and Embryonal. Neoplasms, Nerve Tissue. Digestive System Neoplasms. Neoplasms by Site. Endocrine Gland ... Experimental: PK Expansion Renal Cell Carcinoma - Group A *Everolimus 10 mg by mouth once daily for each cycle (MUST BE TAKEN ... Experimental: PK Expansion Renal Cell Carcinoma - Group B *Everolimus 10 mg by mouth once daily for each cycle (MUST BE TAKEN ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT01784861
Insuloma | Define Insuloma at Dictionary.com  Insuloma | Define Insuloma at Dictionary.com
... a benign tumor of the insulin-secreting cells of the pancreas that may produce signs of hypoglycemia. See more. ... Also called islet cell adenoma.. Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc ... a benign tumor of the insulin-secreting cells of the pancreas that may produce signs of hypoglycemia. ...
more infohttps://www.dictionary.com/browse/insuloma
Temozolomide With or Without Capecitabine in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors  Temozolomide With or Without Capecitabine in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors
Adenoma, Islet Cell. *Carcinoma, Islet Cell. .map{width:100%;height:300px;margin-bottom:15px}. Name. Location. ... Gastrinoma, Glucagonoma, Insulinoma, Islet Cell Carcinoma, Pancreatic Polypeptide Tumor, Recurrent Islet Cell Carcinoma, ... cell carcinoma. - Patient must have measurable disease by Response Evaluation Criteria in Solid Tumors. (RECIST) 1.1 criteria; ...
more infohttp://www.knowcancer.com/cancer-trials/NCT01824875/
Mouth symptoms - RightDiagnosis.com  Mouth symptoms - RightDiagnosis.com
Adenoma, Islet Cell ... vomiting*Adenophorea Infections ... cough*Adenosine triphosphatase deficiency, anaemia due to ... ... B-cell chronic lymphocytic leukemia ... shortness of breath*Ba Bow Sen-induced lead poisoning ... vomiting*Baber's syndrome ... Langerhans Cell Histiocytosis ... loose teeth*Lymphatic malformation (LM) ... impaired swallowing. M. *Macroglossia ... dental ... Acinic cell carcinoma ... vomiting*Ackee Fruit Food poisoning ... vomiting*Acorn poisoning ... vomiting*Acousticophobia ... ...
more infohttps://www.rightdiagnosis.com/sym/mouth_symptoms.htm
Liver symptoms - RightDiagnosis.com  Liver symptoms - RightDiagnosis.com
Adenoma, Islet Cell ... jaundice*Adhesive abuse ... liver damage*Adhesive addiction ... liver damage*Adult Cystic Fibrosis ... ... Adult T-Cell leukemia ... enlarged spleen, enlarged liver*Adult T-Cell lymphoma ... enlarged spleen, enlarged liver*Adverse ... B-cell chronic lymphocytic leukemia ... swollen spleen*B-cell prolymphocytic leukaemia ... enlarged spleen*Baber's syndrome ... Pure red cell aplasia, congenital ... liver cirrhosis*Pyruvate carboxylase deficiency ... liver failure. Q. *Q fever ... ...
more infohttps://www.rightdiagnosis.com/sym/liver_symptoms.htm
Pancreatic adenomas in infants and children: current surgical management.  Pancreatic adenomas in infants and children: current surgical management.
Islet cell adenomas are an important consideration in infants and children with hypoglycemia due to hyperinsulinism. Between ... Adenoma, Islet Cell / complications, pathology, surgery*. Child. Child, Preschool. Diazoxide / therapeutic use. Follow-Up ... Islet cell adenomas are an important consideration in infants and children with hypoglycemia due to hyperinsulinism. Between ... Eight patients had single pancreatic adenomas, 5 of whom were infants under 1 yr of age. In 3 infants an adenoma was recognized ...
more infohttp://www.biomedsearch.com/nih/Pancreatic-adenomas-in-infants-children/215734.html
D-glucose | definition of d-glucose by Medical dictionary  D-glucose | definition of d-glucose by Medical dictionary
Insulin-secreting islet-cell adenoma. Contraindications. • Hypersensitivity to drug. • Hyperglycemia, diabetic coma ... Most of the glycogen is stored in the liver and muscle cells. When these and other body cells are saturated with glycogen, the ... The oxidation of glucose produces energy for the body cells; the rate of metabolism is controlled by a number of hormones the ... insulin is required for the use of glucose by cells; in diabetes mellitus, the level of glucose in the blood is excessive, and ...
more infohttps://medical-dictionary.thefreedictionary.com/D-glucose
Neoplasms of the Endocrine Pancreas: Practice Essentials, Background, Pathophysiology  Neoplasms of the Endocrine Pancreas: Practice Essentials, Background, Pathophysiology
Adenoma of islet cells with hyperinsulinism: a review. Ann Surg. 1935. 101:1299. ... Although the term islet cell tumor is often used to identify neoplasms of the endocrine pancreas, this is a misnomer because ... Endocrine system: pancreatic islet cell tumors. In: Abeloff MD, Armitage JO, Lichter AS, eds. Clinical Oncology. 2nd ed. New ... Malignant islet cell tumor of the pancreas associated with high plasma calcitonin and somatostatin levels. Surgery. 1989 Feb. ...
more infohttps://emedicine.medscape.com/article/276943-overview
Cellohexose | definition of cellohexose by Medical dictionary  Cellohexose | definition of cellohexose by Medical dictionary
Insulin-secreting islet-cell adenoma. Contraindications. • Hypersensitivity to drug. • Hyperglycemia, diabetic coma. • ... Most of the glycogen is stored in the liver and muscle cells. When these and other body cells are saturated with glycogen, the ... The oxidation of glucose produces energy for the body cells; the rate of metabolism is controlled by a number of hormones the ... insulin is required for the use of glucose by cells; in diabetes mellitus, the level of glucose in the blood is excessive, and ...
more infohttp://medical-dictionary.thefreedictionary.com/cellohexose
Growth Hormone-Secreting Pituitary Adenoma
     Summary Report | CureHunter  Growth Hormone-Secreting Pituitary Adenoma Summary Report | CureHunter
Growth Hormone-Secreting Pituitary Adenoma: A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH ... Pituitary Neoplasms (Pituitary Adenoma) 3. Adenoma (Adenomas) 4. Carcinoid Tumor (Carcinoid) 5. Islet Cell Adenoma (Islet Cell ... prolactin cell adenomas, melanocorticotroph adenomas and thyrotroph adenomas. ". 01/01/2010 - "Double pituitary adenomas are ... Adenoma, Somatotroph; Adenomas, Somatotroph; GH Secreting Pituitary Adenoma; GH-Secreting Pituitary Adenomas; Pituitary Adenoma ...
more infohttp://www.curehunter.com/public/keywordSummaryD049912-Growth-Hormone-Secreting-Pituitary-Adenoma.do
  • Cyclosporine has been demonstrated to suppress some humoral immunity and to a greater extent, cell-mediated immune reactions such as allograft rejection, delayed hypersensitivity, experimental allergic encephalomyelitis, Freund's adjuvant arthritis, and graft versus host disease in many animal species for a variety of organs. (drugs.com)
  • Hypersecretion of glucagon, somatostatin, chromogranin, or calcitonin, ectopic secretion of ACTH resulting in Cushing's syndrome, and hypersecretion of somatotropin-releasing hormone (causing acromegaly) sometimes occur in non-β-cell tumors. (wikipedia.org)
  • [ 12 ] Pearse first used the term APUD in 1968 to unify a group of functionally and structurally similar neuroendocrine cells that are present throughout the body. (medscape.com)
  • Pluripotential hormone-secreting cells belonging to the APUD cell system (see p. 132) are distributed throughout the human foregut and its endocrine derivatives . (springer.com)
  • Bonfils S, Bader JP: The diagnosis of Zollinger-Ellison syndrome with special reference to the multiple endocrine adenomas, in Progress in Gastroenterology , Vol. 2 ( GB Jersey Glass, editor). (springer.com)
  • The syndrome of watery diarrhea, hypokalemia , and achlorhydria (ie, WDHA syndrome) is a rare condition characterized by severe, watery diarrhea resulting from the oversecretion of vasoactive intestinal peptide (VIP) from non-beta pancreatic islet cells. (medscape.com)
  • People with multiple endocrine neoplasia type 1 are born with one mutated copy of the MEN1 gene in each cell. (thefullwiki.org)
  • Ballard HS, Frame B, Hartsock RJ: Familial multiple endocrine adenoma peptic ulcer complex. (springer.com)
  • The effectiveness of cyclosporine results from specific and reversible inhibition of immunocompetent lymphocytes in the G 0 - and G 1 -phase of the cell cycle. (drugs.com)
  • This graph shows the total number of publications written about "Adenoma, Islet Cell" by people in this website by year, and whether "Adenoma, Islet Cell" was a major or minor topic of these publications. (rush.edu)
  • Then, during their lifetime, the other copy of the gene is mutated in a small number of cells. (thefullwiki.org)
  • These genetic changes result in no functional copies of the MEN1 gene in selected cells, allowing the cells to divide with little control and form tumors. (thefullwiki.org)
  • A severe secretory diarrhea can develop and cause fluid and electrolyte depletion with non-β-cell tumors. (wikipedia.org)
  • Hormones are chemical messengers that travel through the bloodstream and regulate the function of cells and tissues throughout the body. (thefullwiki.org)