A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.
A benign epithelial tumor with a glandular organization.
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
Tumors or cancers of the KIDNEY.
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
A calcium-binding protein that mediates calcium HOMEOSTASIS in KIDNEYS, BRAIN, and other tissues. It is found in well-defined populations of NEURONS and is involved in CALCIUM SIGNALING and NEURONAL PLASTICITY. It is regulated in some tissues by VITAMIN D.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
A family of MARVEL domain-containing proteolipid proteins involved in vesicular trafficking cycling between the GOLGI COMPLEX and the apical PLASMA MEMBRANE.
A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.
A benign epithelial tumor of the LIVER.
Autosomal dominant neoplastic syndrome characterised by genodermatosis, lung cysts, spontaneous and recurrent PNEUMOTHORAX; and RENAL CANCER. It is associated with mutations in the folliculin protein gene (FLCN protein).
Low molecular weight, calcium binding muscle proteins. Their physiological function is possibly related to the contractile process.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Excision of kidney.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A family of medium adaptin protein subunits of approximately 45 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3 and ADAPTOR PROTEIN COMPLEX 4.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
The development of bony substance in normally soft structures.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.
A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.
A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
A specific pair GROUP C CHROMSOMES of the human chromosome classification.
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)
Calcium-binding proteins that are found in DISTAL KIDNEY TUBULES, INTESTINES, BRAIN, and other tissues where they bind, buffer and transport cytoplasmic calcium. Calbindins possess a variable number of EF-HAND MOTIFS which contain calcium-binding sites. Some isoforms are regulated by VITAMIN D.
A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)
Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
Tumors or cancers of the ADRENAL CORTEX.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
DNA present in neoplastic tissue.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
Tumors or cancer of the SALIVARY GLANDS.
Tumors or cancer of the COLON.
Tumors or cancer of the INTESTINES.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Tumors or cancer of the ADRENAL GLANDS.
A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.
Tumors or cancer of the PAROTID GLAND.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.
An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).
Tumors or cancer of the DUODENUM.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
A malignant epithelial tumor with a glandular organization.
A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
Tumors or cancer of the THYROID GLAND.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND.
Endoscopic examination, therapy or surgery of the sigmoid flexure.

Heparin-induced thrombocytopenia: confirmation of diagnosis with in vitro methods. (1/47)

Profound thrombocytopenia developed in a patient during treatment with heparin for venous thrombosis. The platelet count increased toward normal when heparin administration was stopped, but fell abruptly when the drug was again given. Platelet aggregation occurred when heparin was added to the patient's platelet-rich plasma, or to normal platelets plus the patient's serum. This serum also effected release of 3H-serotonin from normal platelets. This pattern of aggregation was clearly different from that occasionally caused by heparin in a control population. The data is consistent with an effect of heparin on platelets, possibly mediated by on immune mechanism.  (+info)

Visual failure from pituitary and parasellar tumours occurring with favourable outcome in pregnant women. (2/47)

Very few cases have been reported of a successful outcome after relief by operation of severe visual failure from a pituitary or other parasellar tumour during the late stages of pregnancy. Two such cases are recorded here together with the obstetric features and follow-up studies of more than three years. Usually the deterioration of vi sion occurs in the latter half of the pregnancy and recovers rapidly after delivery, whether the onset of labour has occurred spontaneously or after induction. In subsequent pregnancies vision deteriorates at an earlier stage and becomes even more marked. Some cases are now occurring even in pregnancies induced by modern fertility drugs. The treatment of choice whenever vision is seriously threatened at any stage of pregnancy is a surgical attack on the pituitary, followed by suitable replacement therapy to ensure that the pregnancy continues.  (+info)

Subclinical Cushing's disease accompanied by malignant hypertension and diabetes mellitus. (3/47)

A 53-year-old woman was admitted because of hypertension and diabetes mellitus. Elevated diastolic blood pressure, hypertensive retinopathy and renal dysfunction indicated malignant hypertension. Adrenocorticotropic hormone (ACTH) and cortisol levels were high although there were no Cushingoid features. One mg dexamethasone administration decreased neither ACTH nor cortisol levels. Brain magnetic resonance imaging revealed a left pituitary tumor (7 mm x 6 mm). Upon removal, the tumor showed positive ACTH staining by immnohistochemistry, and was diagnosed as pituitary ACTH-secreting adenoma (Cushing's disease). Her blood pressure, renal function, blood glucose and hormone levels subsequently improved. Malignant hypertension and deteriorated diabetes mellitus may have been due to subclinical Cushing's disease.  (+info)

Sarcomatoid renal cell carcinoma with foci of chromophobe carcinoma. (4/47)

Both chromophobe carcinoma and sarcomatoid carcinoma of the kidney are rare. The former is characterized by a relatively good prognosis, while the latter is a highly aggressive tumor. Coexistence of the two components in one renal tumor, which has been reported only rarely, is therefore paradoxical. Both sarcomatoid and chromophobe renal carcinoma were diagnosed in a 52-year-old woman following nephrectomy and resection of metastases in the right lobe of the liver. She died of the disease two months after the first operation; only the sarcomatoid component of her tumor was seen in the liver metastasis and the recurrent carcinoma. Differences in phenotype, immunophenotype and DNA-ploidy patterns of the two components are reported. The intensive p53 staining observed only in the sarcomatoid area supports the role of the TP53 gene in the transformation of chromophobe renal carcinoma to sarcomatoid carcinoma.  (+info)

Moyamoya disease associated with pituitary adenoma--report of two cases. (5/47)

Moyamoya disease associated with prolactin (PRL)-producing pituitary adenomas occurred in two females with elevated blood PRL levels (285 and 120 ng/ml). Computed tomography revealed cystic tumors extending from the sella turcica to the suprasellar cistern. Carotid angiography demonstrated stenoses or obstructions of the bilateral internal carotid arteries at their end point and development of bilateral basal moyamoya vessels. Histological diagnosis in one case was PRL-producing chromophobe adenoma. No stigmata of neurofibromatosis or any history of irradiation was found. Compression of carotid arteries by the tumor was unlikely. These cases should therefore be classified as moyamoya disease accompanied by brain tumor, a very rare occurrence. The hypothalamic disturbance caused by moyamoya disease may have induced the hyperprolactinemia, resulting in secondary prolactinoma.  (+info)

Hypopituitarism caused by a melanoma of the pituitary gland. (6/47)

A clinical and pathological description is given of a case of panhypopituitarism caused by a melanoma of the pituitary gland. The possible origins of a melanoma in this site are discussed.  (+info)

Stroke after pituitary irradiation. (7/47)

BACKGROUND AND PURPOSE: Cranial irradiation may lead to accelerated atherosclerosis over several years. Stroke has been described after cranial irradiation administered for a number of conditions. However, pituitary irradiation has only rarely been associated with stroke. CASE DESCRIPTIONS: Two patients, 39 and 46 years of age, suffered strokes 13 and 20 years, respectively, after irradiation for pituitary tumors. Strokes were in the territories of small perforating arteries, but large vessels such as the carotid siphon and anterior cerebral arteries were also abnormal. Other risk factors for stroke were absent. CONCLUSIONS: It is suggested that pituitary irradiation increases the risk of subsequent stroke due to the known effects of ionizing radiation on vascular walls.  (+info)

Histologic coagulative tumor necrosis as a prognostic indicator of renal cell carcinoma aggressiveness. (8/47)

BACKGROUND: Prognostic markers for renal cell carcinoma (RCC), such as patient symptoms, tumor stage, tumor size, and tumor grade, are useful for determining appropriate follow-up and selecting patients for adjuvant therapy. Histologic coagulative tumor necrosis, also reported to be a prognostic marker for RCC, has not previously been extensively described or investigated. Hence, the objective of the current study was to characterize tumor necrosis as a prognostic feature of RCC. METHODS: The authors of the current study identified 3009 patients treated surgically for RCC between 1970 and 2002 from the Mayo Clinic Nephrectomy Registry (Rochester, MN). Associations of tumor necrosis with clinical, laboratory, and pathologic features were examined with chi-square, Fisher exact test, and Wilcoxon rank-sum tests. Cancer-specific survival was estimated with the Kaplan-Meier method, and associations with outcome were assessed with Cox proportional hazard models. RESULTS: Tumor necrosis was present in 690 of 2445 (28%) clear cell, 196 of 421 (47%) papillary, and 28 of 143 (20%) chromophobe RCCs. The risk ratio for death from RCC in patients with necrotic compared with non-necrotic tumors was 5.27 (95% confidence interval [CI]: 4.56-6.09; P < 0.001) for clear cell, 4.20 (CI: 1.65-10.68; P < 0.001) for chromophobe, and 1.49 (CI: 0.81-2.74; P = 0.199) for papillary RCC. The survival difference for clear cell RCC persisted even after multivariate adjustment for tumor stage, size, and grade (risk ratio 1.90; P < 0.001). CONCLUSIONS: Histologic coagulative tumor necrosis is an independent predictor of outcome for clear cell and chromophobe RCC, and it should be routinely reported and used in clinical assessment.  (+info)

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Diana Goodwin, HT in Trenton, New Jersey asks: >>Does anyone have a copy of Hales method for colloidal iron? My pathologist has asked for it specifically, probably because it is cited in the literature for differentiation of chromophobe RCC.
GROSS: ENDOCRINE: Pituitary: Chromophobe Adenoma: Gross fixed tissue large adenoma shown in dissected circle of Willis for illustration of size tumor has been sliced open. ...
In Females: HMG is used in a sequential manner in conjunction with HCG for the induction of ovulation and pregnancy in the anovulatory infertile patient in whom the cause of anovulation is functional (secondary to pituitary insufficiency) and is not due to primary ovarian failure. HMG and HCG may also be used to stimulate the development of multiple follicles in ovulatory patients participating in an in-vitro fertilization program. In Males: HMG is used in conjunction with HCG to stimulate spermatogenesis in primary hypogonadotropic hypogonadism (resulting from hypophysectomy, craniopharyngioma, cerebral aneurysm or chromophobe adenoma ...
PITUITARY CHROMOPHOBE ADENOMAS NEUROLOGY METABOLISM THERAPY. NY 1953 first edition. Springer. Hardcover octavo. 282pp. Owner signed. VG in Good DJ, dj toned and worn. . ...
A chromophobe is a histological structure that does not stain readily, and thus appears relatively pale under the microscope. Chromophobe cells are one of three cell types, the others being basophils and acidophils. One type of chromophobe cell is known as amphophils. Amphophils are epithelial cells found in the anterior and intermediate lobes of the pituitary. Together, these epithelial cells are responsible for producing the hormones of the anterior pituitary and releasing them into the bloodstream. Melanotrophs (also, Melanotropes) are another type of chromophobe which secrete melanocyte stimulating hormone (MSH). Chromophobe also refers to a type of renal cell carcinoma (distinct from clear cell). Chromophobe renal cancer is part of a rare, genetic disorder known as Birt-Hogg-Dubé syndrome. While renal cell carcinoma is one of the most frequently diagnosed cancers, chromophobe renal cancer only accounts for five percent of renal cancer cases. Furthermore, 30% of patients with ...
Macroscopically, the tumor was of black-grayish color and medium consistency with hemorrhage. Histologic sections revealed an admixture of two tumors with fragments contained both populations in juxtaposition (Figure 2). Juxtaposed to tumor #1 and focally infiltrating into it was the second tumor with hemorrhage. The tumor #2 consisted of sheets of large polygonal or round cells with round nuclei, prominent nucleoli and mitotic figures. Most of the cells of tumor #2 have heavily pigmented cytoplasm with the dusty brown pigment. The population of tumor #1 consisted of sheets and nests of smaller monomorphic ovoid or polygonal cells without prominent nucleoli arranged in delicate capillary network. These cells had round to oval nuclei, delicate chromatin and moderate amount of chromophobic to eosinophilic cytoplasm. The cells of tumor #1 showed mild nuclear pleomorphism and no evidence of necrosis. There were also infiltrates of single and clusters of cells of tumor #2 in the capillaries and ...
The postoperative biological behavior of nonfunctioning pituitary adenomas (NFPAs) is variable. Some residual NFPAs are stable long-term, others grow, and
In 1970 a 20 year old woman presented with a pituitary chromophobe adenoma for which she underwent transfrontal pituitary surgery. In 1978 she had to be reoperated on because of local tumour recurrence, resulting in hypopituitarism. Bromocriptine (5 mg/day) was given for 15 years, but the plasma prolactin levels remained elevated. In 2000 the patient presented with signs and symptoms suggestive of a spinal cord lesion at the mid-thoracic level. A magnetic resonance imaging (MRI) scan showed an extensive leptomeningeal mass extending from the brainstem to L5, with a thoracic syringomyelia at the T7-T8 level. The plasma prolactin level was very high (5114 microg/l). A biopsy showed the presence of a metastasised prolactinoma.On administration of high dose cabergoline, 0.5 mg twice a day orally, the plasma prolactin levels decreased within one month and then normalised within 26 months. Tumour load reduced considerably but unfortunately, her signs and symptoms did not improve. This case illustrates ...
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Childhood Atypical Teratoid/Rhabdoid Tumor Childhood Central Nervous System Choriocarcinoma Childhood Central Nervous System Germinoma Childhood Central Nervous System Mixed Germ Cell Tumor Childhood Central Nervous System Teratoma Childhood Central Nervous System Yolk Sac Tumor Childhood Choroid Plexus Tumor Childhood Craniopharyngioma Childhood Ependymoblastoma Childhood Grade I Meningioma Childhood Grade II Meningioma Childhood Grade III Meningioma Childhood Infratentorial Ependymoma Childhood Medulloepithelioma Childhood Mixed Glioma Childhood Oligodendroglioma Childhood Supratentorial Ependymoma Gonadotroph Adenoma Pituitary Basophilic Adenoma Pituitary Chromophobe Adenoma Pituitary Eosinophilic Adenoma Prolactin Secreting Adenoma Recurrent Childhood Acute Lymphoblastic Leukemia Recurrent Childhood Anaplastic Large Cell Lymphoma Recurrent Childhood Brain Stem Glioma Recurrent Childhood Central Nervous System Embryonal Tumor Recurrent Childhood Cerebellar Astrocytoma Recurrent Childhood ...
Most patients with pituitary adenomas present with signs and symptoms of hormone hypersecretion (eg, hyperprolactinemia, growth hormone [GH] excess, or hypercortisolism). However, 25 to 30 percent of pituitary adenomas are clinically nonfunctioning o
Calcitriol is the active form of vitamin D. Parathyroid hormone (PTH) is secreted by the parathyroid glands in the neck. Both these chemicals are responsible for keeping the levels of calcium and phosphorous normal and also play a role in bone health. They can be measured in the blood. In some disorders, PTH or calcitriol levels are elevated, which results in increased calcium absorption from the gut, increased calcium in the bloodstream, and increased calcium excretion in the urine. Increased calcium in the urine can lead to the development of kidney stones. Increased calcium in the bloodstream can have adverse effects on the heart, gut, kidneys, and bones.. Acromegaly is a condition where a pituitary tumor secretes excessive amounts of growth hormone. Patients with acromegaly have been found to have a higher prevalence of kidney stones, urinary calcium, and serum calcium when compared to normal adults. The reason for this is unknown but a suggested mechanism is that growth hormone stimulates ...
MATERIALS AND METHODS: Conventional MR imaging with contrast-enhanced T1WI and arterial spin-labeled perfusion imaging were performed before surgery in 11 consecutive patients with nonfunctioning pituitary macroadenomas. ROIs were drawn on the tumors, and the degrees of enhancement were calculated by dividing the signal intensity on the contrast-enhanced T1WI by that on the nonenhanced TIWI. As an index of tumor perfusion, a quantitative analysis was performed by using normalized tumor blood flow values calculated by dividing the mean value of the tumor region of interest by the mean region of interest values in the 2 cerebellar hemispheres. The relative microvessel attenuation was determined as the total microvessel wall area divided by the entire tissue area on CD-31-stained specimens. The degree of enhancement and the normalized tumor blood flow values were compared with relative microvessel attenuation. Additionally, intra- and postoperative tumor hemorrhages were visually graded.. ...
Liz, I guess you can easily look up the stats in various places for general information e.g. here: http://www.cancer.gov/statistics/find Roughly, it looks this way - kidney cancer is one of the less frequent cancers. Figures in the US and UK are fairly similar and for 2009, in the UK Kidney cancer is the eighth most common cancer in the UK (2009), accounting for around 3% of all new cases. It is the sixth most common cancer among men in the UK (2009), accounting for more than 3% of all new cases of cancer in males. It is the ninth most common cancer among women in the UK (2009), responsible for more than 2% of all new cases of cancer in females.. In both the US and Europe, chromophobe RCC accounts for only about one in twenty cases of RCC. So, on the above figures, You could reckon that chromophobe RCC would account for around 0.15% of cancer cases in men and 0.1% of cancer cases in women. This needs to be tweaked just a little because although kidney cancer is more common in males than in ...
MeSH-minor] Acromegaly / drug therapy. Adolescent. Adrenal Gland Neoplasms / radionuclide imaging. Adult. Aged. Carcinoma / radionuclide imaging. Humans. Indium Radioisotopes / therapeutic use. Insulin-Like Growth Factor I / secretion. Kidney Neoplasms / radionuclide imaging. Melanoma / radionuclide imaging. Middle Aged. Pheochromocytoma / radionuclide imaging. Predictive Value of Tests. Prolactinoma / drug therapy. Radiopharmaceuticals / therapeutic use. Sensitivity and Specificity. Thymoma / radionuclide imaging. Thymus Neoplasms / radionuclide imaging. Thyroid Neoplasms / radionuclide imaging. Thyrotropin / secretion. Treatment ...
Pituitary carcinoma is a rare malignancy and is difficult to manage. Pituitary carcinomas commonly produce either PRL or ACTH, but some do not produce pituitary hormones. The alkylating reagent temozolomide (TMZ) was recently shown to be effective as a treatment for pituitary carcinoma. Most of the published reports of TMZ use in pituitary carcinoma cases were against hormone-producing carcinomas. Only a few patients with a nonfunctioning pituitary carcinoma treated with TMZ have been reported. Here we describe our treatment of a patient with nonfunctioning pituitary carcinoma and a background of multiple endocrine neoplasia type 1. The pituitary carcinoma was accompanied by meningeal dissemination with cerebral and L1 spinal bone metastasis. The patient received continuous dosing of TMZ along with external radiation, followed by standard dosing of TMZ. There was an apparent antitumor response seen in MRI. MGMT, an enzyme antagonized by TMZ, was negative in the tumor. The therapeutic efficacy of TMZ and
Hello eveyone,. Its been awhile since Ive posted on here. I pop in every once in awhile. But today Im looking for a little information. If you know my story. I have had partial neph been one year NED. My son too had RCC this past year. He had total neph. Both of us stage 3. But he was clear cell, me chromophobe (in the middle of a second opinion from my original pathology report; geneticist recommended). Anyways, Thank God I convinced my son to go across the street to MDAnderson for follow up care. He has done genetic testing (no genetic markers) and he is part of their kidney cancer research. This [ast week he finally has had the baseline scans done. The oncologist says things look good but there is some soft tissue near where they did the neph. She says it looks like normal scarring from the radical but they want to watch it for awhile. Has anyone ever had a similiar situation? He had his full neph in November. Hes feeling a bit down because he realized today that he will not feel free from ...
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GriffonCo may replace a product that does not arrive in the condition in which it was sent. Our replacement policy only lasts 3 days from the date your order has been delivered. If 3 days have gone by since your purchase, unfortunately we cannot offer you a replacement. We do require images of the product and packaging in order to review any replacement requests. The replacement must have a visual defect or issue that directly affects the items usability. Contact us directly for more information. ...
TY - JOUR. T1 - Silent corticotroph adenoma with multiple cysts. T2 - Pars intermedia tumor?. AU - Nishioka, Hiroshi. AU - Hirano, Asao. AU - Asa, Sylvia L.. PY - 1992/3. Y1 - 1992/3. N2 - A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the adenoma cells contained reactivity for adrenocorticotropic hormone and beta-endorphin; a few cells stained for beta-subunit of luteinizing hormone. The cysts, interspersed within the tumor, were lined by cuboidal epithelium with foci of stratified squamous epithelium. The lining cells contained immunoreactive keratin; some cells were positive for S-100 protein or glial fibrillary acidic protein, and a few cells were also immuno-stained for adrenocorticotropic hormone and beta-endorphin. It is suggested that this tumor may represent a neoplasm of pars intermedia derivation.. AB - A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, ...
Silent corticotroph adenoma (SCA) is an unusual type of nonfunctioning pituitary adenoma (NFA) that is silent both clinically and biochemically and can only be recognized by positive immunostaining for ACTH. Under rare circumstances, it can transform into hormonally active disease presenting with severe Cushing syndrome. It might often produce diagnostic dilemma with difficult management issue if not thoroughly investigated and subtyped accordingly following surgery. Here, we present a 21-year-old male who initially underwent pituitary adenomectomy for presumed NFA with compressive symptoms. However, he developed recurrent and invasive macroadenoma with severe clinical as well as biochemical hypercortisolism during post-surgical follow-up. Repeat pituitary surgery was carried out urgently as there was significant optic chiasmal compression. Immunohistochemical analysis of the tumor tissue obtained on repeat surgery proved it to be an aggressive corticotroph adenoma. Though not cured, he showed ...
OBJECTIVE: BRAF is an oncogene that is commonly mutated in both melanomas and papillary thyroid carcinomas, usually at position V600E that leads to constitutive activity in the Ras-mitogen-activated protein kinase (MAPK) pathway. We speculated that this same gene may be either mutated at this site, or overexpressed, in pituitary adenomas. DESIGN AND MEASUREMENTS: We sequenced 37 pituitary adenomas for a mutation at the V600E position. In addition, we investigated B-Raf mRNA expression in normal pituitary (n = 5) and nonfunctioning pituitary adenomas (NFPA) (n = 6) by semiquantitative PCR, and in a further 27 pituitary adenomas of various types and 10 normal pituitaries using real-time quantitative PCR. Finally, we explored B-Raf protein expression in 10 normal pituitaries and 12 NFPAs. RESULTS: No sequence mutations for the substitution V600E were identified. B-Raf mRNA was overexpressed in pituitary adenomas compared to normal pituitary, and this was entirely due to overexpression in NFPAs. ...
Background: To compare the effects of contemporary stereotactic radiosurgery (SRS), modern fractionated radiotherapy (FRT), and transsphenoidal surgery on nonfunctioning pituitary macroadenoma. Methods: We enrolled patients with nonfunctioning pituitary macroadenoma. To compare treatment outcomes, the patients were categorized into three groups according to the treatment modality: group 1, patients receiving modern FRT; group 2, patients receiving contemporary SRS; and group 3, patients receiving transsphenoidal surgery. Results: In total, 548 patients with nonfunctioning pituitary macroadenoma were selected for our study. Univariate and multivariate Cox regression analysis results indicated that the treatment modalities were significant independent prognostic factors. In multivariable Cox proportional hazard regression analysis, the adjusted hazard ratios (aHR; 95% confidence interval (CI)) of local recurrence were 0.27 (0.10–0.91) and 1.95 (1.25–2.37) for the SRS and transsphenoidal
Preoperative renal tumor subtype differentiation is definitely important for radiology and urology in clinical practice. vs 40.3180.4833 vs 50.0130.1654 vs 5 0.0010.411 Open in a separate window Note: 1: clear cell renal cell carcinoma; 2: papillary renal cell carcinoma; 3: chromophobic renal cell carcinoma; 4: uroepithelial carcinoma; 5: fat-poor angiomyolipoma. Open in a separate window Figure 3 Box-and-whisker plot of em K /em trans value. Boxes?=?interquartile range, whiskers?=?range of all values, horizontal line within box?=?median em K /em trans, ccRCC?=?clear cell RCC, pRCC?=?papillary RCC, cRCC?=?chromophobic RCC, UEC?=?uroepithelial carcinoma, fpAML?=?fat poor angiomyolipoma. Open in a separate window Figure 4 Box-and-whisker plot of em V /em e value. Boxes?=?interquartile range, whiskers?=?range of all values, horizontal line within box?=?median em V /em e, ccRCC?=?clear cell RCC, pRCC?=?papillary RCC, cRCC?=?chromophobic RCC, UEC?=?uroepithelial carcinoma, fpAML?=?fat poor ...
Glucocorticoids have major effects on adipose tissue metabolism. To study tissue mRNA expression changes induced by chronic elevated endogenous glucocorticoids, we performed RNA sequencing on the subcutaneous adipose tissue from patients with Cushings disease (n=5) compared to patients with nonfunctioning pituitary adenomas (n=11). We found a higher expression of transcripts involved in several metabolic pathways, including lipogenesis, proteolysis and glucose oxidation as well as a decreased expression of transcripts involved in inflammation and protein synthesis. To further study this in a model system, we subjected mice to dexamethasone treatment for 12 weeks and analyzed their inguinal (subcutaneous) fat pads, which led to similar findings. Additionally, mice treated with dexamethasone showed drastic decreases in lean body mass as well as increased fat mass, further supporting the human transcriptomic data. These data provide insight to transcriptional changes that may be responsible for ...
INTRODUCTION: For a clear image to be formed on the retina, the transparency of cornea and lens is essential. Cornea contributes to two-thirds of refractive power and lens to one- third of refractive power. In the visible range of spectrum (380 to 760 nm), the cornea transmits almost 100% of light energy. AIM OF THE STUDY: 1) To evaluate the incidence of lenticular and corneal pigmentation with dose and duration of chlorpromazine therapy. 2 To evaluate the significance of lenticular and corneal pigmentation in causing visual defects . MATERIALS AND METHODS: This clinical study was done to evaluate the incidence of corneal and lenticular pigmentation in patients with long term chlorpromazine therapy and its significance in causing visual defects. The study design was a cross-sectional study conducted in Institute of Mental Health , Ayanavaram, Chennai. The patients included in this study were in-patients residing in the Institute of Mental Health . A total of 100 patients, 50 males and 50 female ...
• A 40-year-old woman had visual loss and a large nonfunctioning pituitary tumor. After partial surgical resection and radiation treatment, clinical and biochem
The Chromophobe (ChRCC) type renal cell cancer is rare and behaves differently than the more common renal cell carcinoma. Consequently it has not been extensively studied. Unfortunately, there are no proven treatments for the metastatic disease and the many drugs that have been approved for clear cell cancer do not work well for this subtype. At one time chemotherapy was thought to be effective but studies did not confirm it. Overexpression of. Read more ...
!%Cognex Corp.%! has released VisionPro Surface, a vision software package for inspecting the surface of materials. It combines new visual defect det
A visual defect in which both eyes cannot focus together on an object because of an imbalance of the eye muscles, leading to squinting or crossed eyes.. ...
TY - JOUR. T1 - Chromophobe renal cell carcinoma with sarcomatoid differentiation. AU - Lauer, Scott R.. AU - Zhou, Ming. AU - Master, Viraj A.. AU - Osunkoya, Adeboye O.. PY - 2013/4/1. Y1 - 2013/4/1. N2 - OBJECTIVE: To investigate the clinicopathologic features of chromophobe renal cell carcinoma with sarcomatoid differentiation. STUDY DESIGN: A search was made through the surgical pathology and expert consult files of two major academic institutions from 2003 to 2011 for cases of chromophobe renal cell carcinoma with sarcomatoid differentiation. RESULTS: Fourteen patients were identified. The patients included 9 males (64%) and 5 females (36%). The mean patient age was 60.4 years (range, 40-82 years). There was a left-sided predominance: left (9 patients) and right (5 patients). The mean tumor size was 14.6 cm (range, 9.5-28.0 cm), and the mean percentage sarcomatoid differentiation was 67% (range, 30-99%). All tumors exhibited moderate to extensive areas of necrosis. The nonsarcomatoid ...
Chromophobe renal cell carcinoma is a rare type of kidney cancer that develops in cells that are involved in the production of urine. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis). Chromophobe renal cell carcinoma usually occurs in adults between the ages of 40 and 60, although it can appear in all age groups. This type of carcinoma is associated with Birt-Hogg-Dubé syndrome, an inherited disorder caused by a mutation in the FLCN gene. The FLCN gene is involved in regulating cell growth, and a mutation in this gene can cause cells to grow out of control. This situation places affected individuals at higher risk of developing chromophobe renal cell carcinoma as well as noncancerous growths in the kidneys, lungs, and hair follicles. Common symptoms include the presence of blood in the urine, ...
Chromophobe renal cell carcinoma is a rare type of kidney cancer that develops in cells that are involved in the production of urine. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis). Chromophobe renal cell carcinoma usually occurs in adults between the ages of 40 and 60, although it can appear in all age groups. This type of carcinoma is associated with Birt-Hogg-Dubé syndrome, an inherited disorder caused by a mutation in the FLCN gene. The FLCN gene is involved in regulating cell growth, and a mutation in this gene can cause cells to grow out of control. This situation places affected individuals at higher risk of developing chromophobe renal cell carcinoma as well as noncancerous growths in the kidneys, lungs, and hair follicles. Common symptoms include the presence of blood in the urine, ...
Despite multiple studies, many clinicopathologic issues about chromophobe renal cell carcinoma (RCC) remain contentious; for example, its biological behavior-whether better or similar to papillary RCC, the incidence of sarcomatoid features, and whether pathologic features such as necrosis, nuclear g
TY - JOUR. T1 - The somatic genomic landscape of chromophobe renal cell carcinoma. AU - The Cancer Genome Atlas Research Network. AU - Davis, Caleb F.. AU - Ricketts, Christopher J.. AU - Wang, Min. AU - Yang, Lixing. AU - Cherniack, Andrew D.. AU - Shen, Hui. AU - Buhay, Christian. AU - Kang, Hyojin. AU - Kim, Sang Cheol. AU - Fahey, Catherine C.. AU - Hacker, Kathryn E.. AU - Bhanot, Gyan. AU - Gordenin, Dmitry A.. AU - Chu, Andy. AU - Gunaratne, Preethi H.. AU - Biehl, Michael. AU - Seth, Sahil. AU - Kaipparettu, Benny A.. AU - Bristow, Christopher A.. AU - Donehower, Lawrence A.. AU - Wallen, Eric M.. AU - Smith, Angela B.. AU - Tickoo, Satish K.. AU - Tamboli, Pheroze. AU - Reuter, Victor. AU - Schmidt, Laura S.. AU - Hsieh, James J.. AU - Choueiri, Toni K.. AU - Hakimi, A. Ari. AU - Chin, Lynda. AU - Meyerson, Matthew. AU - Kucherlapati, Raju. AU - Park, Woong Yang. AU - Robertson, A. Gordon. AU - Laird, Peter W.. AU - Henske, Elizabeth P.. AU - Kwiatkowski, David J.. AU - Park, Peter ...
Comprehensive review of visual defects reported with topiramate Lisa Ford,1 Jeffrey L Goldberg,2 Fred Selan,1 Howard E Greenberg,1 Yingqi Shi1 1Janssen Research & Development, LLC, Titusville, NJ, 2Byers Eye Institute, Stanford University, Palo Alto, CA, USA Objective: The objective of this study was to analyze clinical patterns of visual field defects (VFDs) reported with topiramate treatment and assess possible mechanism of action (MOA) for antiepileptic drug (AED) associated VFDs.Methods: A comprehensive topiramate database review included preclinical data, sponsor’s clinical trials database, postmarketing spontaneous reports, and medical literature. All treatment-emergent adverse events (TEAEs) suggestive of retinal dysfunction/damage were summarized. Relative risk (RR) was computed from topiramate double-blind, placebo-controlled trials (DBPCTs) data.Results: Preclinical studies and medical literature review suggested that despite sharing gamma-aminobutyric acid (GABA)-ergic MOA with
Datasets are collections of data. BioGPS has thousands of datasets available for browsing and which can be easily viewed in our interactive data chart. Learn more.. ...
Ruiz-Cordero R, Rao P, Li L, Qi Y, Atherton D, Peng B, Singh RR, Kim TB, Kawakami F, Routbort MJ, Alouch N, Chow CB, Tang X, Lu W, Brimo F, Matin SF, Wood CG, Tannir NM, Wistuba II, Chen K, Wang J, Medeiros LJ, Karam JA, Tamboli P, Sircar K. Hybrid oncocytic/chromophobe renal tumors are molecularly distinct from oncocytoma and chromophobe renal cell carcinoma. Mod Pathol. 2019 Jun 23. doi: 10.1038/s41379-019-0304-y. [Epub ahead of print] PubMed PMID: 31231128 ...
View all information about common hormonal problems like why they occur and how they can be treated. Each problem is presented in such a way so as to provide simple, practical and solution oriented approach ...
Xiao, Y.; Rabien, A.; Buschow, R.; Amstislavskiy, V.; Busch, J.; Kilic, E.; Villegas, S. L.; Timmermann, B.; Schütte, M.; Mielke, T. et al.; Yaspo, M.-L.; Jung, K.; Meierhofer, D.: Endocytosis-mediated replenishment of amino acids favors cancer cell proliferation and survival in chromophobe renal cell carcinoma. Cancer research: an official organ of the American Association for Cancer Research 2020 (2020 ...
RCC treatment has been classically derived from clinical trials that incorporated all histologies comprising clear cell, papillary, chromophobe, and other rarer subtypes. Most recently, novel therapies (sunitinib and sorafenib) have shown significant clinical activity in advanced RCC and have changed the standard of care in this disease [1-3]. However, pivotal studies with these drugs were performed exclusively in patients with clear cell histology. Therefore, the optimal therapy for papillary and chromophobe histologies remains unknown. Overall, ChRCC is considered to portend a good prognosis and is associated with earlier-stage tumors and longer overall survival in comparison with CCRCC. There are conflicting reports on prognosis in metastatic disease, and few data on response to treatment exist. Increased VEGF-6 and c-Kit (i.e., mast/stem cell growth factor receptor; proto-oncogene c-Kit; tyrosine-protein kinase Kit; or CD117) expressions have been reported in ChRCC, but the relevance of this ...
ABSTRACT Objective: To evaluate the preoperative imaging manifestation and therapeutic effect of laparoscopic simple enucleation (SE) for localized chromophobe renal cell carcinoma (chRCC).. Materials and Methods: Clinical data of 36 patients who underwent laparoscopic SE of localized chRCC at our institute were retrospectively analyzed. All patients underwent preoperative renal protocol CT (unenhanced, arterial, venous, and delayed images). CT scan characteristics were evaluated. After intraoperative occlusion of the renal artery, the tumor was free bluntly along the pseudocapsule and enucleated totally. The patients were followed up regularly after the operation.. Results: Mean tumor diameter was 3.9±1.0 cm, 80% of tumors were homogeneous and all the tumors had complete pseudocapsule. The attenuation values were slightly lower than normal renal cortex and degree of enhancement of the tumors were significantly lower than normal renal cortex. Mean operation time was 104.3±18.2 min. Mean warm ...
Paucity of muscle weakness and wasting of the line least squares method, the standards for clinical effectiveness within the cyst or mass rarely present as marked apathy. For yrs risk remains small. Acth silent corticotroph adenomas, or be detrimental to the anterior aspect of personalitythe narrow models. If treated with uricosuric agents, the fetus usually tolerates seizures without long-term sequelae. The consent to disclosure of sexual or physical may lead, forming a therapeutic trial gh discontinued for months where treatment decisions. As second-line, consider lithium augmentation. Hyperglycaemia experimental studies suggest that when the examiners instructions unquestioningly. To determine statistical signicance categorizing continuous data with % having gonadotrophin deciency yrs after lod. Humeral hypercalcaemia of malignancy seen in many mental ill- nesses and family, housing, employment, and lack of morphologic transition between lamina propria of the earliest signs of glucocorticoid ...
METASTATIC CHROMOPHOBE RCC continued from page 11 chromophobe RCC. The rest had clear cell mRCC. Overall and progression-free survival rates; time to treatment failure; overall, par-tial, and complete response rates; and stable and progressive disease were calculated. fi ed in low, intermediate, and high risk, remarked Yip. When combined, all these factors we uncovered had an appropriate refl ection in stratifying just like wed see in clear cell RCCs. In this study, patients with IMDC fa-vorable criteria (18%) had median overall survival of 31.4 months. Those with in-termediate risk (59%) achieved an over-all survival of 27.3 months, and poor risk patients (23%) had overall survival of 4.8 months. In the past, we didnt have a clear understanding of whether this treatment was applicable to such a rare subtype. Now… we can tell our patients in clinic that theres good grounded evidence for why we can treat them similarly to how we would patients with clear cell RCC. Evaluating Outcomes ...
How do pituitary tumors affect you and what are the risks, symptoms and causes of pituitary tumors? Read on how pituitary tumors affect the quality of your life and just how effective is treatment.
If diagnosed early enough, the prognosis for a pituitary tumor is usually excellent. If diagnosis is delayed, even a nonfunctioning tumor can cause pr
What is Pituitary Tumors? Get the facts about Pituitary Tumors symptoms, testing, treatment and care options from trusted sources.
Care guide for Galactorrhea (Aftercare Instructions). Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
Snellen Test - ask them to stand at 6 metres (measure it out if you need to) and read out the lowest set of letters they can see. In a traditional test, there will be 11 rows of letters, the row with 8th row being the smallest a person with 6/6 vision can read. The biggest letters represent 6/60 vision. Often a smaller 3m Snellen test is used on the ward due to lack of space! Patients should wear their normal glasses - if they have any. You are not an optician - just looking for any serious visual defects! Make sure to test one eye at a time! - ask the patient to cover their eye; just asking them to close it isnt good enough (as it can be difficult for patient,s and they may partially close the eye you are assessing, which obviously has implications for your results ...
The pea sized structure attached to the undersurface of your brain with the help of a thin stalk, and a tumor that develops in here can be dangerous, find out the symptoms.
Happy Monday All! Heres a quick recap of my situation. I havent had a visit from AF in 9 months. After the 1st 3 we discovered a pituitary tumor, once that...
Today we will see the release of the latest Halo 2 autoupdate. I dont know the exact time it will be released, but until you have it you can read all the details of what the AU contains on Bungie.net. ...
... adenoma, bile duct MeSH C04.557.470.035.095 - adenoma, chromophobe MeSH C04.557.470.035.100 - adenoma, islet cell MeSH C04.557. ... adenoma, acidophil MeSH C04.557.465.625.650.075 - adenoma, basophil MeSH C04.557.465.625.650.095 - adenoma, chromophobe MeSH ... adenoma, acidophil MeSH C04.557.580.625.650.075 - adenoma, basophil MeSH C04.557.580.625.650.095 - adenoma, chromophobe MeSH ... adenoma MeSH C04.557.470.035.012 - acth-secreting pituitary adenoma MeSH C04.557.470.035.025 - adenoma, acidophil MeSH C04.557. ...
M8270/0 Chromophobe adenoma (C75.1) M8270/3 Chromophobe carcinoma (C75.1) Chromophobe adenocarcinoma (M8271/0) Prolactinoma ( ... Black adenoma Pigmented adenoma M8373/0 Adrenal cortical adenoma, clear cell (C74.0) M8374/0 Adrenal cortical adenoma, ... Oxyphilic adenoma Oncocytic adenoma Oncocytoma Hurthle cell adenoma (C73.9) Hurthle cell tumor Follicular adenoma, oxyphilic ... NOS Pick tubular adenoma Sertoli cell adenoma Tubular androblastoma, NOS Testicular adenoma M8640/3 Sertoli cell carcinoma (C62 ...
... and renal adenoma. People with suspected kidney cancer should also have their kidney function evaluated to help determine ... Clear cell RCC Multilocular clear cell RCC Papillary RCC Chromophobe RCC Carcinoma of the collecting ducts of Bellini Renal ...
Tumors with increased risk in this disorder are colorectal cancer, gastric adenomas and duodenal adenomas. Nevoid basal cell ... renal cell carcinoma of chromophobe, hybrid oncocytic, or oncocytoma histology; sebaceous carcinoma; and sex cord tumors with ... An individual with this disease will have hundreds to thousands of benign adenomas throughout their colon, which will in most ... Other tumors increased in frequency include; osteomas, adrenal adenomas and carcinomas, thyroid tumors and desmoid tumors. The ...
Hybrid oncocytoma/chromophobe carcinoma, found in 50% of cases, is the most commonly found cancer, followed by chromophobe ... parathyroid adenomas, flecked chorioretinopathy, neurothekeoma, meningiomas, angiofibromas of the face, trichoblastomas, ... People over 20 years of age with BHD have an increased risk of developing slow-growing kidney tumors (chromophobe renal ... Renal tumors can manifest as multiple types of renal cell carcinoma, but certain pathological subtypes (including chromophobe, ...
A third type of pituitary adenoma secretes excess ACTH, which in turn, causes an excess of cortisol to be secreted and is the ... The pars distalis contains two types of cells, including chromophobe cells and chromophil cells. The chromophils can be further ... This hypersecretion often results in the formation of a pituitary adenoma (tumour), which are benign apart from a tiny fraction ... For example, acromegaly results from excessive secretion of growth hormone (GH) often being released by a pituitary adenoma. ...
TCF4 Pituitary adenoma, ACTH-secreting; 219090; AIP Pituitary adenoma, growth hormone-secreting; 102200; AIP Pituitary adenoma ... chromophobe, somatic; 144700; FLCN Renal cell carcinoma; 144700; DIRC2 Renal cell carcinoma; 144700; HNF1A Renal cell carcinoma ... PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, salivary gland pleomorphic; 181030; PLAG1 Adenomatous polyposis ... EIF2B4 Leydig cell adenoma, somatic, with precocious puberty; 176410; LHCGR Leydig cell hypoplasia with hypergonadotropic ...
March 2020). "Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor ... PRCC is generally heterogeneous with areas of necrosis and hemorrhage compared to chromophobe RCC. Solid, small PRCC tumors (. ...
H and E, high power of a chromophobe RCC composed of cells with clear, reticular cytoplasm and some with eosinophilic cytoplasm ... The maximum size of papillary adenoma was 5 mm but is now ≤15 mm in its largest dimension. ... The main prognostic factors in chromophobe RCC are tumor stage, the presence of necrosis, a sarcomatoid and/or rhabdoid ...
H and E, high power of a chromophobe RCC composed of cells with clear, reticular cytoplasm and some with eosinophilic cytoplasm ... The maximum size of papillary adenoma was 5 mm but is now ≤15 mm in its largest dimension. ... The main prognostic factors in chromophobe RCC are tumor stage, the presence of necrosis, a sarcomatoid and/or rhabdoid ...
No article was found for Adenoma, Chromophobe and GNAS[original query]. File Formats Help:. How do I view different file ...
These techniques have identified hormonal production in many chromophobe adenomas, enabling pathologists to identify hormones ... AIP mutation in pituitary adenomas in the 18th century and today. N Engl J Med. 2011 Jan 6. 364(1):43-50. [QxMD MEDLINE Link]. ... Treatment of pituitary adenomas by fractionated stereotactic radiotherapy: a prospective study of 110 patients. Int J Radiat ... Castinetti F, Régis J, Dufour H, Brue T. Role of stereotactic radiosurgery in the management of pituitary adenomas. Nat Rev ...
Chromophobe tumor (morphologic abnormality) {253009008 , SNOMED-CT } Functioning endocrine tumor (morphologic abnormality) { ... Adenoma AND/OR adenocarcinoma (morphologic abnormality) {115215004 , SNOMED-CT } Download Relationships Other Relationships No ...
... most commonly hybrid oncocytic tumors with features of chromophobe renal carcinoma (50%), followed by chromophobe renal cancer ... Chung JY, Ramos-Caro FA, Beers B, Ford MJ, Flowers F. Multiple lipomas, angiolipomas, and parathyroid adenomas in a patient ... Other, less commonly associated features include a large connective-tissue nevus, parathyroid adenomas, flecked ...
... most commonly hybrid oncocytic tumors with features of chromophobe renal carcinoma (50%), followed by chromophobe renal cancer ... Chung JY, Ramos-Caro FA, Beers B, Ford MJ, Flowers F. Multiple lipomas, angiolipomas, and parathyroid adenomas in a patient ... Other, less commonly associated features include a large connective-tissue nevus, parathyroid adenomas, flecked ...
Adenoma, Acidophil 1 0 Adenoma, Chromophobe 1 0 Growth Hormone-Secreting Pituitary Adenoma 1 0 ...
... lactotroph adenomas). Tumours in group II were chromophobe, acidophil, basophil or mixed adenomas with varying number of ... A clinico-pathologic study of pituitary adenomas.. ผู้แต่ง/ผู้ร่วมงาน: Sarkar, C. Roy, S. Kochupillai, N. Gupta, N. Tandon, P N ... lactotroph adenomas) and ACTH in all tumours from patients with Cushing's syndrome (corticotroph adenomas). It was observed, ... Thus growth hormone was demonstrated in all tumours from patients with acromegaly (somatotroph adenomas), prolactin in all
Secretory adenomas are typically monoclonal--that is, they secrete a single hormone. Approximately 1 to 2% of adenomas secrete ... In general, acidophilic cells contain polypeptide hormones, basophilic cells contain glycoprotein hormones, and chromophobes ... GH-secreting adenomas are next most common adenomas, followed by adrenocorticotropic hormone (ACTH)-secreting tumors and ... 21] The vast majority originate in the adenohypophysis and are typically nonsecretory benign adenomas. These adenomas ...
Chromophobe adenomas.. Ramamurthi, B. 1-Dec-1970. Chronic subdural hematoma.. Kalyanaraman, S; Ramamurthi, B; Ramamoorthi, K. ...
Secretory adenomas are typically monoclonal--that is, they secrete a single hormone. Approximately 1 to 2% of adenomas secrete ... In general, acidophilic cells contain polypeptide hormones, basophilic cells contain glycoprotein hormones, and chromophobes ... GH-secreting adenomas are next most common adenomas, followed by adrenocorticotropic hormone (ACTH)-secreting tumors and ... 21] The vast majority originate in the adenohypophysis and are typically nonsecretory benign adenomas. These adenomas ...
These techniques have identified hormonal production in many chromophobe adenomas, enabling pathologists to identify hormones ... AIP mutation in pituitary adenomas in the 18th century and today. N Engl J Med. 2011 Jan 6. 364(1):43-50. [QxMD MEDLINE Link]. ... Treatment of pituitary adenomas by fractionated stereotactic radiotherapy: a prospective study of 110 patients. Int J Radiat ... Castinetti F, Régis J, Dufour H, Brue T. Role of stereotactic radiosurgery in the management of pituitary adenomas. Nat Rev ...
No article was found for Adenoma, Chromophobe and GNAI2[original query]. File Formats Help:. How do I view different file ...
  • Primary intracranial tumors causing DI in dogs and cats include craniopharyngioma, pituitary chromophobe adenoma, and pituitary chromophobe adenocarcinoma and metastatic tumors include metastatic mammary carcinoma, lymphoma, malignant melanoma, and pancreatic carcinoma. (vin.com)
  • The maximum size of papillary adenoma was 5 mm but is now ≤15 mm in its largest dimension. (medscape.com)
  • 11 ] In the upcoming 4th edition of the World Health Organization (WHO) Classification of Tumors of the Urinary System and Male Genital Organs, tumor size using 1.5 cm as a cutoff will be proposed to distinguish renal papillary adenoma from papillary renal cell carcinoma, though it is unclear if the tumor size should be based on fresh, postfixation, or microscopic measurement. (jcancer.org)
  • As a result of variations in its classic appearance, difficulty in standardizing diagnostic criteria, and entities that mimic oncocytoma, such as eosinophilic variant chromophobe renal cell carcinoma (RCC) and succinate dehydrogenase-deficient RCC, pathologic diagnosis remains a challenge. (medscape.com)
  • 5] The differential diagnosis of oncocytoma includes other neoplasms with eosinophilic or oncocytic cytoplasm and primarily chromophobe RCC, as well as clear cell RCC with eosinophilic cytoplasm-an oncocytic variant of papillary RCC. (medscape.com)
  • Oncocytosis is a rare condition characterized by multiple oncocytic tumors with histologic features, including renal oncocytoma, hybrid oncocytic tumor, and, occasionally, chromophobe RCC. (medscape.com)
  • With more than 95% confidence, the nested pattern, myxoid stroma, granular cytoplasm, and round nuclei are likely indicative of renal oncocytoma, whereas varying nuclear size, raisinoid nuclei, and reticular cytoplasm indicate a higher likelihood of chromophobe RCC. (medscape.com)
  • Some growths in the kidney are not cancerous, such as renal adenoma, oncocytoma and angiomyolipoma. (uchicagomedicine.org)
  • Multiple or bilateral renal carcinomas have been reported in association with this syndrome, most commonly hybrid oncocytic tumors with features of chromophobe renal carcinoma (50%), followed by chromophobe renal cancer, clear cell renal carcinoma, and renal oncocytoma. (medscape.com)
  • Liu Q, Cornejo KM, Cheng L, Hutchinson L, Wang M, Zhang S, Tomaszewicz K, Cosar EF, Woda BA, Jiang Z. Next-Generation Sequencing to Detect Deletion of RB1 and ERBB4 Genes in Chromophobe Renal Cell Carcinoma: A Potential Role in Distinguishing Chromophobe Renal Cell Carcinoma from Renal Oncocytoma. (umassmed.edu)
  • The main prognostic factors in chromophobe RCC are tumor stage, the presence of necrosis, a sarcomatoid and/or rhabdoid component, and small vessel invasion. (medscape.com)
  • analysis revealed that posterior lobe enhancement occurred 9.8 ± 1.5 sec (mean ± SEM) before the anterior lobe in healthy subjects, whereas tumor enhancement occurred significantly before the anterior lobe but only slightly before the posterior lobe in patients with adenomas. (1library.net)
  • DICER1 tumor predisposition (DICER1) is characterized by an increased risk for pleuropulmonary blastoma (PPB), pulmonary cysts, thyroid gland neoplasia (multinodular goiter, adenomas, and/or thyroid cancer), ovarian tumors (Sertoli-Leydig cell tumor, gynandroblastoma, and sarcoma), and cystic nephroma. (nih.gov)
  • Renal adenoma - Renal adenomas are the most common form of benign, solid kidney tumor, and are typically small, low-grade growths. (austincyberknife.com)
  • A partir de la TAC se descubren las bullas pulmonares, y otro tumor de las mismas características en otro riñón. (bhdsyndrome.org)
  • Papillary adenomas are also benign renal neoplasms, but they arise from the renal tubular epithelium and almost always are located within the cortex. (medscape.com)
  • Radiologically, papillary RCC or chromophobe RCC were considered as differential diagnoses. (researchsquare.com)
  • Three such types of cells exist in the anterior pituitary gland: acidophils, basophils, and chromophobes. (thefreedictionary.com)
  • Secretory cells in the adenohypophysis are often subdivided into chromophils (acidophils, basophils) and chromophobes based on interaction of the secretory granules with pH-dependent histochemical stain. (msdvetmanual.com)
  • Suprasellar extension of the pituitary adenoma causes compression of the optic chiasm, resulting in the gradual onset of superior bitemporal quadrantopia that may progress to complete bitemporal hemianopsia (see Plate 1-11). (pediagenosis.com)
  • Effectiveness of transsphenoidal surgery is assessed by the findings on postoperative MRI (typically performed 3 months after surgery) and by blood levels of adenoma secretory products that may have been increased before surgery (e.g., α -subunit of glycoprotein hormones). (pediagenosis.com)
  • Tumors resembling chromophobe adenomas of the pituitary gland with eosinophilic granulation on tetrachrome staining. (mhmedical.com)
  • G-protein abnormalities, ras gene mutations, p53 gene deletions, mutations, and rearrangements, and the association of pituitary tumors with the syndrome of multiple endocrine neoplasia have been described and are involved in the development of adenomas in the pituitary gland. (medscape.com)
  • Type III = Forbes-Albright Syndrome: AGS caused by chromophobe prolactin-producing adenoma of the pituitary. (mhmedical.com)
  • PURPOSE: To measure and evaluate the temporal enhancement characteristics of the normal pituitary gland and pituitary adenoma. (1library.net)
  • Pituitary adenomas, with a few exceptions, are not under the control of hypothalamic releasing factors. (medscape.com)
  • Chromophobe RCC is a relatively rare type, with pale, large cells. (mountsinai.org)
  • [ 4 ] Nonfunctioning adenomas are associated with hypermethylation of p16 prolactinomas, and corticotropin-secreting tumors express galectin-3 (Gal-3), a gene involved in cell growth and apoptosis. (medscape.com)
  • Recurrence of the pituitary adenoma after transsphenoidal surgery can be treated with stereotactic Gamma knife radiotherapy. (pediagenosis.com)
  • This study contained 152 cases, including 48 follicular nodular disease (FND), 29 follicular adenoma (FA), 57 papillary thyroid carcinoma (PTC), 12 follicular thyroid carcinoma (FTC), 3 medullary thyroid carcinoma (MTC), 2 poorly differentiated thyroid carcinoma (PDTC) and 1 undifferentiated thyroid carcinoma (UDTC). (ijpmonline.org)
  • TROP-2 can be considered a useful marker for distinguishing PTC fv cases from follicular nodular disease and follicular adenoma cases because of its high sensitivity in the identification of papillary carcinomas of the thyroid. (ijpmonline.org)
  • PMID 15871511 -- "Stereotactic radiosurgery for pituitary adenomas: an intermediate review of its safety, efficacy, and role in the neurosurgical treatment armamentarium. (wikibooks.org)
  • Chromophobe renal cell carcinoma with retrograde venous invasion and gain of chromosome 21: potential harbingers of aggressive clinical behavior. (henryford.com)
  • Conventional) Clear cell carcinoma showing typical low-grade areas with nests, acini and cords of clear cells intermixed with a delicate network of capillary vessels (a HE, 100x).Chromophobe carcinoma typically shows sheets of cells separated by incomplete septations. (fasttrackmerealestate.com)
  • Thyroid findings include adenomas, goiters and the most important to surveil for, follicular carcinoma. (nextstepsinderm.com)
  • hepatocellular adenoma a large, fleshy, hypervascular tumor of the liver occurring chiefly in women of childbearing age and associated with oral contraceptive use. (thefreedictionary.com)
  • It defines a clinical syndrome and not simply the occurrence of hemorrhage into an adenoma, which is a common and frequently subclinical process. (medlink.com)
  • Some cases present with coagulation necrosis of a pituitary adenoma without massive hemorrhage. (medlink.com)
  • some contain hormone-secreting cells ( endocrine-active adenomas ) but some are not secretory ( endocrine-inactive adenomas ) . (thefreedictionary.com)
  • Adenoma, Acidophil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (ouhsc.edu)
  • Below are the most recent publications written about "Adenoma, Acidophil" by people in Profiles. (ouhsc.edu)
  • such as papillary, clear cell RCC, nephrogenic adenoma, and urothelial neoplasms 1 sept Hirsch). (aserfavite.es)
  • A -mm papillary adenoma fig. And whether conventional randomized studies are justied for some this may contribute to its ultimate state and future offending, mitoses can occur at rest or straining. (tetratherapeutics.com)
  • G-protein abnormalities, ras gene mutations, p53 gene deletions, mutations, and rearrangements, and the association of pituitary tumors with the syndrome of multiple endocrine neoplasia have been described and are involved in the development of adenomas in the pituitary gland. (medscape.com)
  • Forty-two patients (81%) had a prolactinoma, with the remaining patients having the following tumors: nonfunctioning pituitary adenoma (6 patients), growth hormone-secreting adenoma (2 patients), mammosomatotroph cell adenoma (1 patient), and ACTH-secreting adenoma (1 patient). (medscape.com)
  • Stomach tumors, rare in F344 rats (10/2960, 0.3%), were found in the dosed male rats: one adenocarcinoma and a sarcoma in a high-dose male and in the low-dose group a squamous cell papilloma, fibrosarcoma, adenoma, and mucinous adenocarcinoma. (nih.gov)
  • Villwock et al noted that pituitary tumors constitute 10-15% of all diagnosed intracranial tumors, 90% of which are adenomas. (medscape.com)
  • 4] Nonfunctioning adenomas are associated with hypermethylation of p16 prolactinomas, and corticotropin-secreting tumors express galectin-3 (Gal-3), a gene involved in cell growth and apoptosis. (medscape.com)
  • Multiple or bilateral renal carcinomas have been reported in association with this syndrome, most commonly hybrid oncocytic tumors with features of chromophobe renal carcinoma (50%), followed by chromophobe renal cancer, clear cell renal carcinoma, and renal oncocytoma. (medscape.com)
  • A mutation in the PAX8 gene could prevent or disrupt normal development This entity should not be confused with the similar-sounding metanephric adenoma PAX8 has been shown to interact with NK2 homeobox 1. (aserfavite.es)
  • In another patient with a chromophobe adenoma of the hypophysis, it reduced the excessively elevated prolactin levels. (nih.gov)
  • It can be used as a diagnostic aid in such conditions as panhypopituitarism, pituitary dwarfism, chromophobe adenoma, postsurgical craniopharyngioma, hypophysectomy, pituitary trauma, acromegaly, gigantism and problems of growth and stature. (nih.gov)
  • 13. Metastatic chromophobe renal cell carcinoma to the brain . (nih.gov)
  • The results showed very convincing immuno-boostering effects of female sterilization includes % other diseases such as chromophobe rcc metastatic thyroid carcinoma: History of the residuals against the predictor variable with n degrees of freedom, p. (tetratherapeutics.com)
  • Fahlbusch, R. and Buchfelder, M. (1988) Transsphenoidal Surgery of Parasellar Pituitary Adenomas. (scirp.org)
  • Numerous technological adjuncts are used during transsphenoidal surgery for non-functioning pituitary adenomas (NFPAs), including endoscopy, neuronavigation, intraoperative magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) diversion, and dural closure techniques. (cns.org)
  • MR quantitative 3D shape analysis helps to distinguish mucinous cystic neoplasm from serous oligocystic adenoma. (lifexsoft.org)
  • FSH can be used to distinguish: adenomas of FSH-producing cells, giant cell adenomas, null cell adenomas and oncocytic cells that normally express focally FSH and/or LH as well as any growth of gonadotropic origin. (anacrom.com)
  • 12. Epithelial and organ-related marker expression in pituitary adenomas. (nih.gov)
  • Adenoma, Chromophobe" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • Chromophobe renal cell carci- noma, adenocarcinoma, and verrucous pseudohyperplastic carcinoma: Although the work along. (norfolkspca.com)
  • Carcinoma en cuirasse. (thefreelibrary.com)
  • Serous tubal intraepithelial PAX2: A reliable marker for nephrogenic adenoma 1 feb Pan-cytokeratin and PAX8 were diffusely positive. (aserfavite.es)
  • We aimed to review the literature with regard to CSF leakage associated with nonsurgical treatment of pituitary adenomas in order to further understand the clinical and pathological situations in which this entity typically arises. (medscape.com)
  • We report a 59 year male with a Knosp grade 4, Hardys C giant pituitary adenoma in which two-stage near total surgical resection via an expanded endoscopic transphenoidal approach and subsequent bifrontal craniotomy was achieved. (scirp.org)
  • Typically, resection rates of less than 50% have been reported following surgery on giant pituitary adenomas. (scirp.org)
  • This case serves to illustrate that even in the presence of significant suprasellar and parasellar extension, radical resection of giant pituitary adenomas can be achieved. (scirp.org)
  • Level III: Transsphenoidal microsurgery or endoscopic resection is recommended for symptomatic relief of nonfunctioning pituitary adenoma patients. (cns.org)
  • Conclusions Nonsurgical development of CSF rhinorrhea may occur in the setting of pituitary adenomas, especially following favorable response of invasive prolactinomas to initiation of dopamine agonist therapy. (medscape.com)
  • The operative management of giant pituitary adenomas represents a significant challenge for neurosurgeons. (scirp.org)
  • What is the role of technical aspects (adjuvants) of operative treatment of patients with nonfunctioning pituitary adenomas (NFPAs)? (cns.org)
  • We suggest that PAX8 is an additional marker for identifying nephrogenic adenoma. (aserfavite.es)
  • both may be derived from proliferating renal tubular cells in the urinary tract f renal transcription factor PAX2 as a diagnostic marker for nephrogenic adenoma. (aserfavite.es)
  • 2008) The Endonasal Microscopic Approach for Pituitary Adenomas and Other Parasellartumors: A 10-Year Experience. (scirp.org)
  • 2007) Surgical Treatment of Giant Pituitary Adenomas: Strategies and Results in a Series of 95 Consecutive Patients. (scirp.org)
  • Results Fifty-two patients with spontaneous or medically induced CSF leaks in the setting of a pituitary adenoma were identified from 29 articles published from 1980 through 2011. (medscape.com)
  • [ 22 , 29 ] There have also been several reports of development of CSF rhinorrhea following the initiation of medical treatment for pituitary adenomas. (medscape.com)
  • Thus, the incidence of alveolar/bronchiolar adenomas among males is not considered to be related to treatment with C.I. Disperse Yellow 3. (nih.gov)
  • This graph shows the total number of publications written about "Adenoma, Chromophobe" by people in this website by year, and whether "Adenoma, Chromophobe" was a major or minor topic of these publications. (rush.edu)
  • His top areas of expertise are Pancreatic Cancer, Pancreatic Adenoma, Familial Pancreatic Cancer, and Cholangiocarcinoma. (medifind.com)
  • Sinha, S. and Sharma, B.S. (2010) Giant Pituitary Adenomas-An Enigma Revisited. (scirp.org)
  • Methods A review of the literature was conducted to identify all cases of nonsurgical CSF leaks associated with pituitary adenomas. (medscape.com)
  • Shrestha, R., Bao, G., Wei, W. and Wang, M. (2012) Risk Factor Analysis on the Predictors of the Transsphenoidal Pituitary Surgery on Marco-Adenomas: A Multivariate Logistic Regression Analysis. (scirp.org)
  • 0.05) lower incidence of hepatocellular adenomas was detected among low-dose (7/50, 1/49, 7/49) male mice. (nih.gov)
  • Pituitary adenomas, with a few exceptions, are not under the control of hypothalamic releasing factors. (medscape.com)

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