A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.
A benign epithelial tumor with a glandular organization.
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
Tumors or cancers of the KIDNEY.
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
A calcium-binding protein that mediates calcium HOMEOSTASIS in KIDNEYS, BRAIN, and other tissues. It is found in well-defined populations of NEURONS and is involved in CALCIUM SIGNALING and NEURONAL PLASTICITY. It is regulated in some tissues by VITAMIN D.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
A family of MARVEL domain-containing proteolipid proteins involved in vesicular trafficking cycling between the GOLGI COMPLEX and the apical PLASMA MEMBRANE.
A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.
A benign epithelial tumor of the LIVER.
Autosomal dominant neoplastic syndrome characterised by genodermatosis, lung cysts, spontaneous and recurrent PNEUMOTHORAX; and RENAL CANCER. It is associated with mutations in the folliculin protein gene (FLCN protein).
Low molecular weight, calcium binding muscle proteins. Their physiological function is possibly related to the contractile process.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Excision of kidney.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A family of medium adaptin protein subunits of approximately 45 KDa in size. They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 3 and ADAPTOR PROTEIN COMPLEX 4.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
The development of bony substance in normally soft structures.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.
A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.
A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
A specific pair GROUP C CHROMSOMES of the human chromosome classification.
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)
Calcium-binding proteins that are found in DISTAL KIDNEY TUBULES, INTESTINES, BRAIN, and other tissues where they bind, buffer and transport cytoplasmic calcium. Calbindins possess a variable number of EF-HAND MOTIFS which contain calcium-binding sites. Some isoforms are regulated by VITAMIN D.
A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)
Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
Tumors or cancers of the ADRENAL CORTEX.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
DNA present in neoplastic tissue.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
Tumors or cancer of the SALIVARY GLANDS.
Tumors or cancer of the COLON.
Tumors or cancer of the INTESTINES.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Tumors or cancer of the ADRENAL GLANDS.
A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.
Tumors or cancer of the PAROTID GLAND.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.
An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).
Tumors or cancer of the DUODENUM.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
A malignant epithelial tumor with a glandular organization.
A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
Tumors or cancer of the THYROID GLAND.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND.
Endoscopic examination, therapy or surgery of the sigmoid flexure.

Heparin-induced thrombocytopenia: confirmation of diagnosis with in vitro methods. (1/47)

Profound thrombocytopenia developed in a patient during treatment with heparin for venous thrombosis. The platelet count increased toward normal when heparin administration was stopped, but fell abruptly when the drug was again given. Platelet aggregation occurred when heparin was added to the patient's platelet-rich plasma, or to normal platelets plus the patient's serum. This serum also effected release of 3H-serotonin from normal platelets. This pattern of aggregation was clearly different from that occasionally caused by heparin in a control population. The data is consistent with an effect of heparin on platelets, possibly mediated by on immune mechanism.  (+info)

Visual failure from pituitary and parasellar tumours occurring with favourable outcome in pregnant women. (2/47)

Very few cases have been reported of a successful outcome after relief by operation of severe visual failure from a pituitary or other parasellar tumour during the late stages of pregnancy. Two such cases are recorded here together with the obstetric features and follow-up studies of more than three years. Usually the deterioration of vi sion occurs in the latter half of the pregnancy and recovers rapidly after delivery, whether the onset of labour has occurred spontaneously or after induction. In subsequent pregnancies vision deteriorates at an earlier stage and becomes even more marked. Some cases are now occurring even in pregnancies induced by modern fertility drugs. The treatment of choice whenever vision is seriously threatened at any stage of pregnancy is a surgical attack on the pituitary, followed by suitable replacement therapy to ensure that the pregnancy continues.  (+info)

Subclinical Cushing's disease accompanied by malignant hypertension and diabetes mellitus. (3/47)

A 53-year-old woman was admitted because of hypertension and diabetes mellitus. Elevated diastolic blood pressure, hypertensive retinopathy and renal dysfunction indicated malignant hypertension. Adrenocorticotropic hormone (ACTH) and cortisol levels were high although there were no Cushingoid features. One mg dexamethasone administration decreased neither ACTH nor cortisol levels. Brain magnetic resonance imaging revealed a left pituitary tumor (7 mm x 6 mm). Upon removal, the tumor showed positive ACTH staining by immnohistochemistry, and was diagnosed as pituitary ACTH-secreting adenoma (Cushing's disease). Her blood pressure, renal function, blood glucose and hormone levels subsequently improved. Malignant hypertension and deteriorated diabetes mellitus may have been due to subclinical Cushing's disease.  (+info)

Sarcomatoid renal cell carcinoma with foci of chromophobe carcinoma. (4/47)

Both chromophobe carcinoma and sarcomatoid carcinoma of the kidney are rare. The former is characterized by a relatively good prognosis, while the latter is a highly aggressive tumor. Coexistence of the two components in one renal tumor, which has been reported only rarely, is therefore paradoxical. Both sarcomatoid and chromophobe renal carcinoma were diagnosed in a 52-year-old woman following nephrectomy and resection of metastases in the right lobe of the liver. She died of the disease two months after the first operation; only the sarcomatoid component of her tumor was seen in the liver metastasis and the recurrent carcinoma. Differences in phenotype, immunophenotype and DNA-ploidy patterns of the two components are reported. The intensive p53 staining observed only in the sarcomatoid area supports the role of the TP53 gene in the transformation of chromophobe renal carcinoma to sarcomatoid carcinoma.  (+info)

Moyamoya disease associated with pituitary adenoma--report of two cases. (5/47)

Moyamoya disease associated with prolactin (PRL)-producing pituitary adenomas occurred in two females with elevated blood PRL levels (285 and 120 ng/ml). Computed tomography revealed cystic tumors extending from the sella turcica to the suprasellar cistern. Carotid angiography demonstrated stenoses or obstructions of the bilateral internal carotid arteries at their end point and development of bilateral basal moyamoya vessels. Histological diagnosis in one case was PRL-producing chromophobe adenoma. No stigmata of neurofibromatosis or any history of irradiation was found. Compression of carotid arteries by the tumor was unlikely. These cases should therefore be classified as moyamoya disease accompanied by brain tumor, a very rare occurrence. The hypothalamic disturbance caused by moyamoya disease may have induced the hyperprolactinemia, resulting in secondary prolactinoma.  (+info)

Hypopituitarism caused by a melanoma of the pituitary gland. (6/47)

A clinical and pathological description is given of a case of panhypopituitarism caused by a melanoma of the pituitary gland. The possible origins of a melanoma in this site are discussed.  (+info)

Stroke after pituitary irradiation. (7/47)

BACKGROUND AND PURPOSE: Cranial irradiation may lead to accelerated atherosclerosis over several years. Stroke has been described after cranial irradiation administered for a number of conditions. However, pituitary irradiation has only rarely been associated with stroke. CASE DESCRIPTIONS: Two patients, 39 and 46 years of age, suffered strokes 13 and 20 years, respectively, after irradiation for pituitary tumors. Strokes were in the territories of small perforating arteries, but large vessels such as the carotid siphon and anterior cerebral arteries were also abnormal. Other risk factors for stroke were absent. CONCLUSIONS: It is suggested that pituitary irradiation increases the risk of subsequent stroke due to the known effects of ionizing radiation on vascular walls.  (+info)

Histologic coagulative tumor necrosis as a prognostic indicator of renal cell carcinoma aggressiveness. (8/47)

BACKGROUND: Prognostic markers for renal cell carcinoma (RCC), such as patient symptoms, tumor stage, tumor size, and tumor grade, are useful for determining appropriate follow-up and selecting patients for adjuvant therapy. Histologic coagulative tumor necrosis, also reported to be a prognostic marker for RCC, has not previously been extensively described or investigated. Hence, the objective of the current study was to characterize tumor necrosis as a prognostic feature of RCC. METHODS: The authors of the current study identified 3009 patients treated surgically for RCC between 1970 and 2002 from the Mayo Clinic Nephrectomy Registry (Rochester, MN). Associations of tumor necrosis with clinical, laboratory, and pathologic features were examined with chi-square, Fisher exact test, and Wilcoxon rank-sum tests. Cancer-specific survival was estimated with the Kaplan-Meier method, and associations with outcome were assessed with Cox proportional hazard models. RESULTS: Tumor necrosis was present in 690 of 2445 (28%) clear cell, 196 of 421 (47%) papillary, and 28 of 143 (20%) chromophobe RCCs. The risk ratio for death from RCC in patients with necrotic compared with non-necrotic tumors was 5.27 (95% confidence interval [CI]: 4.56-6.09; P < 0.001) for clear cell, 4.20 (CI: 1.65-10.68; P < 0.001) for chromophobe, and 1.49 (CI: 0.81-2.74; P = 0.199) for papillary RCC. The survival difference for clear cell RCC persisted even after multivariate adjustment for tumor stage, size, and grade (risk ratio 1.90; P < 0.001). CONCLUSIONS: Histologic coagulative tumor necrosis is an independent predictor of outcome for clear cell and chromophobe RCC, and it should be routinely reported and used in clinical assessment.  (+info)

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Diana Goodwin, HT in Trenton, New Jersey asks: >>Does anyone have a copy of Hales method for colloidal iron? My pathologist has asked for it specifically, probably because it is cited in the literature for differentiation of chromophobe RCC.
GROSS: ENDOCRINE: Pituitary: Chromophobe Adenoma: Gross fixed tissue large adenoma shown in dissected circle of Willis for illustration of size tumor has been sliced open. ...
In Females: HMG is used in a sequential manner in conjunction with HCG for the induction of ovulation and pregnancy in the anovulatory infertile patient in whom the cause of anovulation is functional (secondary to pituitary insufficiency) and is not due to primary ovarian failure. HMG and HCG may also be used to stimulate the development of multiple follicles in ovulatory patients participating in an in-vitro fertilization program. In Males: HMG is used in conjunction with HCG to stimulate spermatogenesis in primary hypogonadotropic hypogonadism (resulting from hypophysectomy, craniopharyngioma, cerebral aneurysm or chromophobe adenoma ...
PITUITARY CHROMOPHOBE ADENOMAS NEUROLOGY METABOLISM THERAPY. NY 1953 first edition. Springer. Hardcover octavo. 282pp. Owner signed. VG in Good DJ, dj toned and worn. . ...
A chromophobe is a histological structure that does not stain readily, and thus appears relatively pale under the microscope. Chromophobe cells are one of three cell types, the others being basophils and acidophils. One type of chromophobe cell is known as amphophils. Amphophils are epithelial cells found in the anterior and intermediate lobes of the pituitary. Together, these epithelial cells are responsible for producing the hormones of the anterior pituitary and releasing them into the bloodstream. Melanotrophs (also, Melanotropes) are another type of chromophobe which secrete melanocyte stimulating hormone (MSH). Chromophobe also refers to a type of renal cell carcinoma (distinct from clear cell). Chromophobe renal cancer is part of a rare, genetic disorder known as Birt-Hogg-Dubé syndrome. While renal cell carcinoma is one of the most frequently diagnosed cancers, chromophobe renal cancer only accounts for five percent of renal cancer cases. Furthermore, 30% of patients with ...
Macroscopically, the tumor was of black-grayish color and medium consistency with hemorrhage. Histologic sections revealed an admixture of two tumors with fragments contained both populations in juxtaposition (Figure 2). Juxtaposed to tumor #1 and focally infiltrating into it was the second tumor with hemorrhage. The tumor #2 consisted of sheets of large polygonal or round cells with round nuclei, prominent nucleoli and mitotic figures. Most of the cells of tumor #2 have heavily pigmented cytoplasm with the dusty brown pigment. The population of tumor #1 consisted of sheets and nests of smaller monomorphic ovoid or polygonal cells without prominent nucleoli arranged in delicate capillary network. These cells had round to oval nuclei, delicate chromatin and moderate amount of chromophobic to eosinophilic cytoplasm. The cells of tumor #1 showed mild nuclear pleomorphism and no evidence of necrosis. There were also infiltrates of single and clusters of cells of tumor #2 in the capillaries and ...
The postoperative biological behavior of nonfunctioning pituitary adenomas (NFPAs) is variable. Some residual NFPAs are stable long-term, others grow, and
In 1970 a 20 year old woman presented with a pituitary chromophobe adenoma for which she underwent transfrontal pituitary surgery. In 1978 she had to be reoperated on because of local tumour recurrence, resulting in hypopituitarism. Bromocriptine (5 mg/day) was given for 15 years, but the plasma prolactin levels remained elevated. In 2000 the patient presented with signs and symptoms suggestive of a spinal cord lesion at the mid-thoracic level. A magnetic resonance imaging (MRI) scan showed an extensive leptomeningeal mass extending from the brainstem to L5, with a thoracic syringomyelia at the T7-T8 level. The plasma prolactin level was very high (5114 microg/l). A biopsy showed the presence of a metastasised prolactinoma.On administration of high dose cabergoline, 0.5 mg twice a day orally, the plasma prolactin levels decreased within one month and then normalised within 26 months. Tumour load reduced considerably but unfortunately, her signs and symptoms did not improve. This case illustrates ...
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Childhood Atypical Teratoid/Rhabdoid Tumor Childhood Central Nervous System Choriocarcinoma Childhood Central Nervous System Germinoma Childhood Central Nervous System Mixed Germ Cell Tumor Childhood Central Nervous System Teratoma Childhood Central Nervous System Yolk Sac Tumor Childhood Choroid Plexus Tumor Childhood Craniopharyngioma Childhood Ependymoblastoma Childhood Grade I Meningioma Childhood Grade II Meningioma Childhood Grade III Meningioma Childhood Infratentorial Ependymoma Childhood Medulloepithelioma Childhood Mixed Glioma Childhood Oligodendroglioma Childhood Supratentorial Ependymoma Gonadotroph Adenoma Pituitary Basophilic Adenoma Pituitary Chromophobe Adenoma Pituitary Eosinophilic Adenoma Prolactin Secreting Adenoma Recurrent Childhood Acute Lymphoblastic Leukemia Recurrent Childhood Anaplastic Large Cell Lymphoma Recurrent Childhood Brain Stem Glioma Recurrent Childhood Central Nervous System Embryonal Tumor Recurrent Childhood Cerebellar Astrocytoma Recurrent Childhood ...
Most patients with pituitary adenomas present with signs and symptoms of hormone hypersecretion (eg, hyperprolactinemia, growth hormone [GH] excess, or hypercortisolism). However, 25 to 30 percent of pituitary adenomas are clinically nonfunctioning o
Calcitriol is the active form of vitamin D. Parathyroid hormone (PTH) is secreted by the parathyroid glands in the neck. Both these chemicals are responsible for keeping the levels of calcium and phosphorous normal and also play a role in bone health. They can be measured in the blood. In some disorders, PTH or calcitriol levels are elevated, which results in increased calcium absorption from the gut, increased calcium in the bloodstream, and increased calcium excretion in the urine. Increased calcium in the urine can lead to the development of kidney stones. Increased calcium in the bloodstream can have adverse effects on the heart, gut, kidneys, and bones.. Acromegaly is a condition where a pituitary tumor secretes excessive amounts of growth hormone. Patients with acromegaly have been found to have a higher prevalence of kidney stones, urinary calcium, and serum calcium when compared to normal adults. The reason for this is unknown but a suggested mechanism is that growth hormone stimulates ...
MATERIALS AND METHODS: Conventional MR imaging with contrast-enhanced T1WI and arterial spin-labeled perfusion imaging were performed before surgery in 11 consecutive patients with nonfunctioning pituitary macroadenomas. ROIs were drawn on the tumors, and the degrees of enhancement were calculated by dividing the signal intensity on the contrast-enhanced T1WI by that on the nonenhanced TIWI. As an index of tumor perfusion, a quantitative analysis was performed by using normalized tumor blood flow values calculated by dividing the mean value of the tumor region of interest by the mean region of interest values in the 2 cerebellar hemispheres. The relative microvessel attenuation was determined as the total microvessel wall area divided by the entire tissue area on CD-31-stained specimens. The degree of enhancement and the normalized tumor blood flow values were compared with relative microvessel attenuation. Additionally, intra- and postoperative tumor hemorrhages were visually graded.. ...
Liz, I guess you can easily look up the stats in various places for general information e.g. here: http://www.cancer.gov/statistics/find Roughly, it looks this way - kidney cancer is one of the less frequent cancers. Figures in the US and UK are fairly similar and for 2009, in the UK Kidney cancer is the eighth most common cancer in the UK (2009), accounting for around 3% of all new cases. It is the sixth most common cancer among men in the UK (2009), accounting for more than 3% of all new cases of cancer in males. It is the ninth most common cancer among women in the UK (2009), responsible for more than 2% of all new cases of cancer in females.. In both the US and Europe, chromophobe RCC accounts for only about one in twenty cases of RCC. So, on the above figures, You could reckon that chromophobe RCC would account for around 0.15% of cancer cases in men and 0.1% of cancer cases in women. This needs to be tweaked just a little because although kidney cancer is more common in males than in ...
MeSH-minor] Acromegaly / drug therapy. Adolescent. Adrenal Gland Neoplasms / radionuclide imaging. Adult. Aged. Carcinoma / radionuclide imaging. Humans. Indium Radioisotopes / therapeutic use. Insulin-Like Growth Factor I / secretion. Kidney Neoplasms / radionuclide imaging. Melanoma / radionuclide imaging. Middle Aged. Pheochromocytoma / radionuclide imaging. Predictive Value of Tests. Prolactinoma / drug therapy. Radiopharmaceuticals / therapeutic use. Sensitivity and Specificity. Thymoma / radionuclide imaging. Thymus Neoplasms / radionuclide imaging. Thyroid Neoplasms / radionuclide imaging. Thyrotropin / secretion. Treatment ...
Pituitary carcinoma is a rare malignancy and is difficult to manage. Pituitary carcinomas commonly produce either PRL or ACTH, but some do not produce pituitary hormones. The alkylating reagent temozolomide (TMZ) was recently shown to be effective as a treatment for pituitary carcinoma. Most of the published reports of TMZ use in pituitary carcinoma cases were against hormone-producing carcinomas. Only a few patients with a nonfunctioning pituitary carcinoma treated with TMZ have been reported. Here we describe our treatment of a patient with nonfunctioning pituitary carcinoma and a background of multiple endocrine neoplasia type 1. The pituitary carcinoma was accompanied by meningeal dissemination with cerebral and L1 spinal bone metastasis. The patient received continuous dosing of TMZ along with external radiation, followed by standard dosing of TMZ. There was an apparent antitumor response seen in MRI. MGMT, an enzyme antagonized by TMZ, was negative in the tumor. The therapeutic efficacy of TMZ and
Hello eveyone,. Its been awhile since Ive posted on here. I pop in every once in awhile. But today Im looking for a little information. If you know my story. I have had partial neph been one year NED. My son too had RCC this past year. He had total neph. Both of us stage 3. But he was clear cell, me chromophobe (in the middle of a second opinion from my original pathology report; geneticist recommended). Anyways, Thank God I convinced my son to go across the street to MDAnderson for follow up care. He has done genetic testing (no genetic markers) and he is part of their kidney cancer research. This [ast week he finally has had the baseline scans done. The oncologist says things look good but there is some soft tissue near where they did the neph. She says it looks like normal scarring from the radical but they want to watch it for awhile. Has anyone ever had a similiar situation? He had his full neph in November. Hes feeling a bit down because he realized today that he will not feel free from ...
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GriffonCo may replace a product that does not arrive in the condition in which it was sent. Our replacement policy only lasts 3 days from the date your order has been delivered. If 3 days have gone by since your purchase, unfortunately we cannot offer you a replacement. We do require images of the product and packaging in order to review any replacement requests. The replacement must have a visual defect or issue that directly affects the items usability. Contact us directly for more information. ...
TY - JOUR. T1 - Silent corticotroph adenoma with multiple cysts. T2 - Pars intermedia tumor?. AU - Nishioka, Hiroshi. AU - Hirano, Asao. AU - Asa, Sylvia L.. PY - 1992/3. Y1 - 1992/3. N2 - A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the adenoma cells contained reactivity for adrenocorticotropic hormone and beta-endorphin; a few cells stained for beta-subunit of luteinizing hormone. The cysts, interspersed within the tumor, were lined by cuboidal epithelium with foci of stratified squamous epithelium. The lining cells contained immunoreactive keratin; some cells were positive for S-100 protein or glial fibrillary acidic protein, and a few cells were also immuno-stained for adrenocorticotropic hormone and beta-endorphin. It is suggested that this tumor may represent a neoplasm of pars intermedia derivation.. AB - A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, ...
Silent corticotroph adenoma (SCA) is an unusual type of nonfunctioning pituitary adenoma (NFA) that is silent both clinically and biochemically and can only be recognized by positive immunostaining for ACTH. Under rare circumstances, it can transform into hormonally active disease presenting with severe Cushing syndrome. It might often produce diagnostic dilemma with difficult management issue if not thoroughly investigated and subtyped accordingly following surgery. Here, we present a 21-year-old male who initially underwent pituitary adenomectomy for presumed NFA with compressive symptoms. However, he developed recurrent and invasive macroadenoma with severe clinical as well as biochemical hypercortisolism during post-surgical follow-up. Repeat pituitary surgery was carried out urgently as there was significant optic chiasmal compression. Immunohistochemical analysis of the tumor tissue obtained on repeat surgery proved it to be an aggressive corticotroph adenoma. Though not cured, he showed ...
OBJECTIVE: BRAF is an oncogene that is commonly mutated in both melanomas and papillary thyroid carcinomas, usually at position V600E that leads to constitutive activity in the Ras-mitogen-activated protein kinase (MAPK) pathway. We speculated that this same gene may be either mutated at this site, or overexpressed, in pituitary adenomas. DESIGN AND MEASUREMENTS: We sequenced 37 pituitary adenomas for a mutation at the V600E position. In addition, we investigated B-Raf mRNA expression in normal pituitary (n = 5) and nonfunctioning pituitary adenomas (NFPA) (n = 6) by semiquantitative PCR, and in a further 27 pituitary adenomas of various types and 10 normal pituitaries using real-time quantitative PCR. Finally, we explored B-Raf protein expression in 10 normal pituitaries and 12 NFPAs. RESULTS: No sequence mutations for the substitution V600E were identified. B-Raf mRNA was overexpressed in pituitary adenomas compared to normal pituitary, and this was entirely due to overexpression in NFPAs. ...
Background: To compare the effects of contemporary stereotactic radiosurgery (SRS), modern fractionated radiotherapy (FRT), and transsphenoidal surgery on nonfunctioning pituitary macroadenoma. Methods: We enrolled patients with nonfunctioning pituitary macroadenoma. To compare treatment outcomes, the patients were categorized into three groups according to the treatment modality: group 1, patients receiving modern FRT; group 2, patients receiving contemporary SRS; and group 3, patients receiving transsphenoidal surgery. Results: In total, 548 patients with nonfunctioning pituitary macroadenoma were selected for our study. Univariate and multivariate Cox regression analysis results indicated that the treatment modalities were significant independent prognostic factors. In multivariable Cox proportional hazard regression analysis, the adjusted hazard ratios (aHR; 95% confidence interval (CI)) of local recurrence were 0.27 (0.10–0.91) and 1.95 (1.25–2.37) for the SRS and transsphenoidal
Preoperative renal tumor subtype differentiation is definitely important for radiology and urology in clinical practice. vs 40.3180.4833 vs 50.0130.1654 vs 5 0.0010.411 Open in a separate window Note: 1: clear cell renal cell carcinoma; 2: papillary renal cell carcinoma; 3: chromophobic renal cell carcinoma; 4: uroepithelial carcinoma; 5: fat-poor angiomyolipoma. Open in a separate window Figure 3 Box-and-whisker plot of em K /em trans value. Boxes?=?interquartile range, whiskers?=?range of all values, horizontal line within box?=?median em K /em trans, ccRCC?=?clear cell RCC, pRCC?=?papillary RCC, cRCC?=?chromophobic RCC, UEC?=?uroepithelial carcinoma, fpAML?=?fat poor angiomyolipoma. Open in a separate window Figure 4 Box-and-whisker plot of em V /em e value. Boxes?=?interquartile range, whiskers?=?range of all values, horizontal line within box?=?median em V /em e, ccRCC?=?clear cell RCC, pRCC?=?papillary RCC, cRCC?=?chromophobic RCC, UEC?=?uroepithelial carcinoma, fpAML?=?fat poor ...
Glucocorticoids have major effects on adipose tissue metabolism. To study tissue mRNA expression changes induced by chronic elevated endogenous glucocorticoids, we performed RNA sequencing on the subcutaneous adipose tissue from patients with Cushings disease (n=5) compared to patients with nonfunctioning pituitary adenomas (n=11). We found a higher expression of transcripts involved in several metabolic pathways, including lipogenesis, proteolysis and glucose oxidation as well as a decreased expression of transcripts involved in inflammation and protein synthesis. To further study this in a model system, we subjected mice to dexamethasone treatment for 12 weeks and analyzed their inguinal (subcutaneous) fat pads, which led to similar findings. Additionally, mice treated with dexamethasone showed drastic decreases in lean body mass as well as increased fat mass, further supporting the human transcriptomic data. These data provide insight to transcriptional changes that may be responsible for ...
INTRODUCTION: For a clear image to be formed on the retina, the transparency of cornea and lens is essential. Cornea contributes to two-thirds of refractive power and lens to one- third of refractive power. In the visible range of spectrum (380 to 760 nm), the cornea transmits almost 100% of light energy. AIM OF THE STUDY: 1) To evaluate the incidence of lenticular and corneal pigmentation with dose and duration of chlorpromazine therapy. 2 To evaluate the significance of lenticular and corneal pigmentation in causing visual defects . MATERIALS AND METHODS: This clinical study was done to evaluate the incidence of corneal and lenticular pigmentation in patients with long term chlorpromazine therapy and its significance in causing visual defects. The study design was a cross-sectional study conducted in Institute of Mental Health , Ayanavaram, Chennai. The patients included in this study were in-patients residing in the Institute of Mental Health . A total of 100 patients, 50 males and 50 female ...
• A 40-year-old woman had visual loss and a large nonfunctioning pituitary tumor. After partial surgical resection and radiation treatment, clinical and biochem
The Chromophobe (ChRCC) type renal cell cancer is rare and behaves differently than the more common renal cell carcinoma. Consequently it has not been extensively studied. Unfortunately, there are no proven treatments for the metastatic disease and the many drugs that have been approved for clear cell cancer do not work well for this subtype. At one time chemotherapy was thought to be effective but studies did not confirm it. Overexpression of. Read more ...
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A visual defect in which both eyes cannot focus together on an object because of an imbalance of the eye muscles, leading to squinting or crossed eyes.. ...
TY - JOUR. T1 - Chromophobe renal cell carcinoma with sarcomatoid differentiation. AU - Lauer, Scott R.. AU - Zhou, Ming. AU - Master, Viraj A.. AU - Osunkoya, Adeboye O.. PY - 2013/4/1. Y1 - 2013/4/1. N2 - OBJECTIVE: To investigate the clinicopathologic features of chromophobe renal cell carcinoma with sarcomatoid differentiation. STUDY DESIGN: A search was made through the surgical pathology and expert consult files of two major academic institutions from 2003 to 2011 for cases of chromophobe renal cell carcinoma with sarcomatoid differentiation. RESULTS: Fourteen patients were identified. The patients included 9 males (64%) and 5 females (36%). The mean patient age was 60.4 years (range, 40-82 years). There was a left-sided predominance: left (9 patients) and right (5 patients). The mean tumor size was 14.6 cm (range, 9.5-28.0 cm), and the mean percentage sarcomatoid differentiation was 67% (range, 30-99%). All tumors exhibited moderate to extensive areas of necrosis. The nonsarcomatoid ...
Chromophobe renal cell carcinoma is a rare type of kidney cancer that develops in cells that are involved in the production of urine. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis). Chromophobe renal cell carcinoma usually occurs in adults between the ages of 40 and 60, although it can appear in all age groups. This type of carcinoma is associated with Birt-Hogg-Dubé syndrome, an inherited disorder caused by a mutation in the FLCN gene. The FLCN gene is involved in regulating cell growth, and a mutation in this gene can cause cells to grow out of control. This situation places affected individuals at higher risk of developing chromophobe renal cell carcinoma as well as noncancerous growths in the kidneys, lungs, and hair follicles. Common symptoms include the presence of blood in the urine, ...
Chromophobe renal cell carcinoma is a rare type of kidney cancer that develops in cells that are involved in the production of urine. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis). Chromophobe renal cell carcinoma usually occurs in adults between the ages of 40 and 60, although it can appear in all age groups. This type of carcinoma is associated with Birt-Hogg-Dubé syndrome, an inherited disorder caused by a mutation in the FLCN gene. The FLCN gene is involved in regulating cell growth, and a mutation in this gene can cause cells to grow out of control. This situation places affected individuals at higher risk of developing chromophobe renal cell carcinoma as well as noncancerous growths in the kidneys, lungs, and hair follicles. Common symptoms include the presence of blood in the urine, ...
Despite multiple studies, many clinicopathologic issues about chromophobe renal cell carcinoma (RCC) remain contentious; for example, its biological behavior-whether better or similar to papillary RCC, the incidence of sarcomatoid features, and whether pathologic features such as necrosis, nuclear g
TY - JOUR. T1 - The somatic genomic landscape of chromophobe renal cell carcinoma. AU - The Cancer Genome Atlas Research Network. AU - Davis, Caleb F.. AU - Ricketts, Christopher J.. AU - Wang, Min. AU - Yang, Lixing. AU - Cherniack, Andrew D.. AU - Shen, Hui. AU - Buhay, Christian. AU - Kang, Hyojin. AU - Kim, Sang Cheol. AU - Fahey, Catherine C.. AU - Hacker, Kathryn E.. AU - Bhanot, Gyan. AU - Gordenin, Dmitry A.. AU - Chu, Andy. AU - Gunaratne, Preethi H.. AU - Biehl, Michael. AU - Seth, Sahil. AU - Kaipparettu, Benny A.. AU - Bristow, Christopher A.. AU - Donehower, Lawrence A.. AU - Wallen, Eric M.. AU - Smith, Angela B.. AU - Tickoo, Satish K.. AU - Tamboli, Pheroze. AU - Reuter, Victor. AU - Schmidt, Laura S.. AU - Hsieh, James J.. AU - Choueiri, Toni K.. AU - Hakimi, A. Ari. AU - Chin, Lynda. AU - Meyerson, Matthew. AU - Kucherlapati, Raju. AU - Park, Woong Yang. AU - Robertson, A. Gordon. AU - Laird, Peter W.. AU - Henske, Elizabeth P.. AU - Kwiatkowski, David J.. AU - Park, Peter ...
Comprehensive review of visual defects reported with topiramate Lisa Ford,1 Jeffrey L Goldberg,2 Fred Selan,1 Howard E Greenberg,1 Yingqi Shi1 1Janssen Research & Development, LLC, Titusville, NJ, 2Byers Eye Institute, Stanford University, Palo Alto, CA, USA Objective: The objective of this study was to analyze clinical patterns of visual field defects (VFDs) reported with topiramate treatment and assess possible mechanism of action (MOA) for antiepileptic drug (AED) associated VFDs.Methods: A comprehensive topiramate database review included preclinical data, sponsor’s clinical trials database, postmarketing spontaneous reports, and medical literature. All treatment-emergent adverse events (TEAEs) suggestive of retinal dysfunction/damage were summarized. Relative risk (RR) was computed from topiramate double-blind, placebo-controlled trials (DBPCTs) data.Results: Preclinical studies and medical literature review suggested that despite sharing gamma-aminobutyric acid (GABA)-ergic MOA with
Datasets are collections of data. BioGPS has thousands of datasets available for browsing and which can be easily viewed in our interactive data chart. Learn more.. ...
Ruiz-Cordero R, Rao P, Li L, Qi Y, Atherton D, Peng B, Singh RR, Kim TB, Kawakami F, Routbort MJ, Alouch N, Chow CB, Tang X, Lu W, Brimo F, Matin SF, Wood CG, Tannir NM, Wistuba II, Chen K, Wang J, Medeiros LJ, Karam JA, Tamboli P, Sircar K. Hybrid oncocytic/chromophobe renal tumors are molecularly distinct from oncocytoma and chromophobe renal cell carcinoma. Mod Pathol. 2019 Jun 23. doi: 10.1038/s41379-019-0304-y. [Epub ahead of print] PubMed PMID: 31231128 ...
View all information about common hormonal problems like why they occur and how they can be treated. Each problem is presented in such a way so as to provide simple, practical and solution oriented approach ...
Xiao, Y.; Rabien, A.; Buschow, R.; Amstislavskiy, V.; Busch, J.; Kilic, E.; Villegas, S. L.; Timmermann, B.; Schütte, M.; Mielke, T. et al.; Yaspo, M.-L.; Jung, K.; Meierhofer, D.: Endocytosis-mediated replenishment of amino acids favors cancer cell proliferation and survival in chromophobe renal cell carcinoma. Cancer research: an official organ of the American Association for Cancer Research 2020 (2020 ...
RCC treatment has been classically derived from clinical trials that incorporated all histologies comprising clear cell, papillary, chromophobe, and other rarer subtypes. Most recently, novel therapies (sunitinib and sorafenib) have shown significant clinical activity in advanced RCC and have changed the standard of care in this disease [1-3]. However, pivotal studies with these drugs were performed exclusively in patients with clear cell histology. Therefore, the optimal therapy for papillary and chromophobe histologies remains unknown. Overall, ChRCC is considered to portend a good prognosis and is associated with earlier-stage tumors and longer overall survival in comparison with CCRCC. There are conflicting reports on prognosis in metastatic disease, and few data on response to treatment exist. Increased VEGF-6 and c-Kit (i.e., mast/stem cell growth factor receptor; proto-oncogene c-Kit; tyrosine-protein kinase Kit; or CD117) expressions have been reported in ChRCC, but the relevance of this ...
ABSTRACT Objective: To evaluate the preoperative imaging manifestation and therapeutic effect of laparoscopic simple enucleation (SE) for localized chromophobe renal cell carcinoma (chRCC).. Materials and Methods: Clinical data of 36 patients who underwent laparoscopic SE of localized chRCC at our institute were retrospectively analyzed. All patients underwent preoperative renal protocol CT (unenhanced, arterial, venous, and delayed images). CT scan characteristics were evaluated. After intraoperative occlusion of the renal artery, the tumor was free bluntly along the pseudocapsule and enucleated totally. The patients were followed up regularly after the operation.. Results: Mean tumor diameter was 3.9±1.0 cm, 80% of tumors were homogeneous and all the tumors had complete pseudocapsule. The attenuation values were slightly lower than normal renal cortex and degree of enhancement of the tumors were significantly lower than normal renal cortex. Mean operation time was 104.3±18.2 min. Mean warm ...
Paucity of muscle weakness and wasting of the line least squares method, the standards for clinical effectiveness within the cyst or mass rarely present as marked apathy. For yrs risk remains small. Acth silent corticotroph adenomas, or be detrimental to the anterior aspect of personalitythe narrow models. If treated with uricosuric agents, the fetus usually tolerates seizures without long-term sequelae. The consent to disclosure of sexual or physical may lead, forming a therapeutic trial gh discontinued for months where treatment decisions. As second-line, consider lithium augmentation. Hyperglycaemia experimental studies suggest that when the examiners instructions unquestioningly. To determine statistical signicance categorizing continuous data with % having gonadotrophin deciency yrs after lod. Humeral hypercalcaemia of malignancy seen in many mental ill- nesses and family, housing, employment, and lack of morphologic transition between lamina propria of the earliest signs of glucocorticoid ...
METASTATIC CHROMOPHOBE RCC continued from page 11 chromophobe RCC. The rest had clear cell mRCC. Overall and progression-free survival rates; time to treatment failure; overall, par-tial, and complete response rates; and stable and progressive disease were calculated. fi ed in low, intermediate, and high risk, remarked Yip. When combined, all these factors we uncovered had an appropriate refl ection in stratifying just like wed see in clear cell RCCs. In this study, patients with IMDC fa-vorable criteria (18%) had median overall survival of 31.4 months. Those with in-termediate risk (59%) achieved an over-all survival of 27.3 months, and poor risk patients (23%) had overall survival of 4.8 months. In the past, we didnt have a clear understanding of whether this treatment was applicable to such a rare subtype. Now… we can tell our patients in clinic that theres good grounded evidence for why we can treat them similarly to how we would patients with clear cell RCC. Evaluating Outcomes ...
How do pituitary tumors affect you and what are the risks, symptoms and causes of pituitary tumors? Read on how pituitary tumors affect the quality of your life and just how effective is treatment.
If diagnosed early enough, the prognosis for a pituitary tumor is usually excellent. If diagnosis is delayed, even a nonfunctioning tumor can cause pr
What is Pituitary Tumors? Get the facts about Pituitary Tumors symptoms, testing, treatment and care options from trusted sources.
Care guide for Galactorrhea (Aftercare Instructions). Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
Snellen Test - ask them to stand at 6 metres (measure it out if you need to) and read out the lowest set of letters they can see. In a traditional test, there will be 11 rows of letters, the row with 8th row being the smallest a person with 6/6 vision can read. The biggest letters represent 6/60 vision. Often a smaller 3m Snellen test is used on the ward due to lack of space! Patients should wear their normal glasses - if they have any. You are not an optician - just looking for any serious visual defects! Make sure to test one eye at a time! - ask the patient to cover their eye; just asking them to close it isnt good enough (as it can be difficult for patient,s and they may partially close the eye you are assessing, which obviously has implications for your results ...
The pea sized structure attached to the undersurface of your brain with the help of a thin stalk, and a tumor that develops in here can be dangerous, find out the symptoms.
Happy Monday All! Heres a quick recap of my situation. I havent had a visit from AF in 9 months. After the 1st 3 we discovered a pituitary tumor, once that...
Today we will see the release of the latest Halo 2 autoupdate. I dont know the exact time it will be released, but until you have it you can read all the details of what the AU contains on Bungie.net. ...
... adenoma, bile duct MeSH C04.557.470.035.095 - adenoma, chromophobe MeSH C04.557.470.035.100 - adenoma, islet cell MeSH C04.557. ... adenoma, acidophil MeSH C04.557.465.625.650.075 - adenoma, basophil MeSH C04.557.465.625.650.095 - adenoma, chromophobe MeSH ... adenoma, acidophil MeSH C04.557.580.625.650.075 - adenoma, basophil MeSH C04.557.580.625.650.095 - adenoma, chromophobe MeSH ... adenoma MeSH C04.557.470.035.012 - acth-secreting pituitary adenoma MeSH C04.557.470.035.025 - adenoma, acidophil MeSH C04.557. ...
M8270/0 Chromophobe adenoma (C75.1) M8270/3 Chromophobe carcinoma (C75.1) Chromophobe adenocarcinoma (M8271/0) Prolactinoma ( ... Black adenoma Pigmented adenoma M8373/0 Adrenal cortical adenoma, clear cell (C74.0) M8374/0 Adrenal cortical adenoma, ... Oxyphilic adenoma Oncocytic adenoma Oncocytoma Hurthle cell adenoma (C73.9) Hurthle cell tumor Follicular adenoma, oxyphilic ... NOS Pick tubular adenoma Sertoli cell adenoma Tubular androblastoma, NOS Testicular adenoma M8640/3 Sertoli cell carcinoma (C62 ...
... and renal adenoma. People with suspected kidney cancer should also have their kidney function evaluated to help determine ... Clear cell RCC Multilocular clear cell RCC Papillary RCC Chromophobe RCC Carcinoma of the collecting ducts of Bellini Renal ...
Tumors with increased risk in this disorder are colorectal cancer, gastric adenomas and duodenal adenomas. Nevoid basal cell ... renal cell carcinoma of chromophobe, hybrid oncocytic, or oncocytoma histology; sebaceous carcinoma; and sex cord tumors with ... An individual with this disease will have hundreds to thousands of benign adenomas throughout their colon, which will in most ... Other tumors increased in frequency include; osteomas, adrenal adenomas and carcinomas, thyroid tumors and desmoid tumors. The ...
Hybrid oncocytoma/chromophobe carcinoma, found in 50% of cases, is the most commonly found cancer, followed by chromophobe ... parathyroid adenomas, flecked chorioretinopathy, neurothekeoma, meningiomas, angiofibromas of the face, trichoblastomas, ... People over 20 years of age with BHD have an increased risk of developing slow-growing kidney tumors (chromophobe renal ... Renal tumors can manifest as multiple types of renal cell carcinoma, but certain pathological subtypes (including chromophobe, ...
A third type of pituitary adenoma secretes excess ACTH, which in turn, causes an excess of cortisol to be secreted and is the ... The pars distalis contains two types of cells, including chromophobe cells and chromophil cells. The chromophils can be further ... This hypersecretion often results in the formation of a pituitary adenoma (tumour), which are benign apart from a tiny fraction ... Tropic hormones Pituitary adenoma Triple bolus test Posterior pituitary Hypopituitarism Hypothalamic-pituitary-somatic axis ...
March 2002). "Characterization of serotonin(4) receptors in adrenocortical aldosterone-producing adenomas: in vivo and in vitro ... "G-protein-coupled receptors in aldosterone-producing adenomas: a potential cause of hyperaldosteronism". J. Endocrinol. 195 (1 ...
TCF4 Pituitary adenoma, ACTH-secreting; 219090; AIP Pituitary adenoma, growth hormone-secreting; 102200; AIP Pituitary adenoma ... chromophobe, somatic; 144700; FLCN Renal cell carcinoma; 144700; DIRC2 Renal cell carcinoma; 144700; HNF1A Renal cell carcinoma ... PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, salivary gland pleomorphic; 181030; PLAG1 Adenomatous polyposis ... EIF2B4 Leydig cell adenoma, somatic, with precocious puberty; 176410; LHCGR Leydig cell hypoplasia with hypergonadotropic ...
March 2020). "Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor ... PRCC is generally heterogeneous with areas of necrosis and hemorrhage compared to chromophobe RCC. Solid, small PRCC tumors (. ...
... a prolactin-secreting pituitary adenoma. ... Chromophobe cell. Posterior. *Pars nervosa. *Median eminence. * ...
Endocrine disease is characterized by misregulated hormone release (a productive pituitary adenoma), inappropriate response to ... due to a pituitary adenoma that ultimately causes endogenous hypercortisolism by stimulating the adrenal glands.[11] Some ...
The most common neoplasm affecting the thyroid gland is a benign adenoma, usually presenting as a painless mass in the neck.[64 ... and thyroid adenomas. Malignant nodules, which only occur in about 5% of nodules, include follicular, papillary, medullary ... or from pituitary adenomas which may cause an overproduction of thyroid stimulating hormone.[45] Hyperthyroidism often causes a ... a solitary thyroid adenoma, or inflammation. Other causes include drug-induced excess of iodine, particularly from amiodarone, ...
Pituitary adenomas, noncancerous tumors that occur in the pituitary gland.. All of the functions of the pituitary gland can be ...
Chromophobe adenoma definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look ... chromophil adenoma, chromophile, chromophilia, chromophilous, chromophobe, chromophobe adenoma, chromophobe cell, chromophobia ...
Welcome to the Pathology Education Informational Resource (PEIR) Digital Library, a multidisciplinary public access image database for use in medical education. ...
MalaCards based summary : Chromophobe Adenoma, also known as adenoma, chromophobe, is related to adenoma and galactorrhea. An ... MalaCards organs/tissues related to Chromophobe Adenoma:. 41 Pituitary, T Cells, Thyroid, Ovary, Skin, Testes ... Drugs for Chromophobe Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):. (show all 15) #. Name. ... Articles related to Chromophobe Adenoma:. (show top 50) (show all 95) #. Title. Authors. Year. ...
Definition of Chromophobe adenoma with photos and pictures, translations, sample usage, and additional links for more ... chromophobe. chromophobe adenoma (current term). chromophobe cells of anterior lobe of hypophysis. chromophobe granules. ... Chromophobe Adenoma Images Lexicographical Neighbors of Chromophobe Adenoma. chromonychia. chromonychias. chromopectic. ... Medical Definition of Chromophobe adenoma. 1. A tumour of the adenohypophysis whose cells do not stain with either acid or ...
... - 2 Studies Found. Status. Study Terminated. Study Name: Gamma-Secretase Inhibitor RO4929097 in Treating ...
The fine structure of blood vessels in chromophobe adenoma. Together they form a unique fingerprint. * Chromophobe Adenoma ... Hirano, Asao ; Tomiyasu, Uwamie ; Zimmerman, H. M. / The fine structure of blood vessels in chromophobe adenoma. In: Acta ... keywords = "Chromophobe Adenoma, Fenestrae, Pituitary Gland",. author = "Asao Hirano and Uwamie Tomiyasu and Zimmerman, {H. M ... Hirano, A., Tomiyasu, U., & Zimmerman, H. M. (1972). The fine structure of blood vessels in chromophobe adenoma. Acta ...
Adenoma, Chromophobe/blood supply , Capillaries/ultrastructure , Humans , Pituitary Gland/blood supply , Pituitary Neoplasms/ ... Adenoma, Chromophobe Language: English Journal: Neurol India Year: 1978 Type: Article ... Adenoma, Chromophobe Language: English Journal: Neurol India Year: 1978 Type: Article ... Ultrastructure of capillaries in chromophobe adenoma. Ultrastructure of capillaries in chromophobe adenoma. ...
PITUITARY CHROMOPHOBE ADENOMAS NEUROLOGY METABOLISM THERAPY. NY 1953 first edition. Springer. Hardcover octavo. 282pp. Owner ... PITUITARY CHROMOPHOBE ADENOMAS NEUROLOGY METABOLISM THERAPY. by Nurnberger, John I. and Saul R. Korey. Seller. Xerxesbooks. ...
present with chromophobe adenoma* In pituitary tumour. *production in mammals* In neurohormone ...
... suffering from a large pituitary adenoma and panhypopituitarism, was found to have severely elevated thyrotrophin (thyroid- ... After surgical removal of the pituitary chromophobe adenoma, T4 levels returned to normal (6.8 μg/dL) and TSH levels improved ... Hypothyroidism Secondary to Biologically Inactive Thyroid-Stimulating Hormone Secretion by a Pituitary Chromophobe Adenoma: ... Hypothyroidism Secondary to Biologically Inactive Thyroid-Stimulating Hormone Secretion by a Pituitary Chromophobe Adenoma: ...
Chromophobe adenoma: Adenoma of the pituitary gland, consisting of cells that are neither acidophilic nor basophilic. ... Hypotheses for their origin include reduced pituitary dopamine concentration and/or a vascular isolation of the adenoma cells. ...
Malignant chromophobe adenoma with extensive skull destruction. Report of a case.. 5931783 Radiology, 1966 March : 86(3)532-3 ...
Papanastasiou MRI-pituitary adenoma Chromophobe pituitary et al. (21) 2012 with inhomogeneous adenoma. Diffuse 1 case (60/f) ... Carcinoma Ex Pleomorphic Adenoma Presented as a Gigantic Tumor: Treatment and Diagnostic Challenges.. ...
... they are increased in chromophobe adenomas.. Claudius cells cuboidal cells, which along with Böttchers cells form the floor of ... chromophobe cell. Chromophobe.. Clara cell. A cuboidal epithelial cell found in the lining of the terminal and the respiratory ... chromophobe cells faintly staining cells in the adenohypophysis; some are nongranular (either nonsecretory, immature ...
Chromophobe: Chromophobe adenoma; pituitary adenoma; undifferentiated cell adenoma; an adenoma of the hypophysis composed of ... Chromophobe adenoma: Tumor of the anterior portion of the pituitary gland.. Chronic: Term used to describe long-lasting ... Pituitary Adenoma: Pituitary adenomas cause most cases of Cushings syndrome. They are benign, or non-cancerous, tumors of the ... Adrenal gland tumor: A benign tumor, or adenoma, that usually results in the excess production of adrenal gland hormones. ...
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Metanephric adenoma: primitive appearing blue cells, WT1+.. *Mucinous tubular and spindle cell carcinoma: may look like ... Behavior is better than clear cell RCC but worse than chromophobe RCC. ...
Chromophobe RCC - 5%. - Loss of multiple chromosomes resulting in hypodiploidy. - Prognosis is the best among 3 histotypes. ... Describe a papillary adenoma - Always within the cortex. - AKA "cortical adenoma". - Small. - Usually ...
chromophobe adenoma 10.1. SERPINA7 TRH 33. atypical follicular adenoma 10.0. CALCA TG ...
Large invasive chromophobe adenoma with well-preserved pituitary gland : Report of a case. KEPES J. J. ... Selective excision of adenomas originating in or extending into the pituitary stalk with preservation of pituitary function ... Supradiaphragmatic ectopic adrenocorticotropic hormone-secreting adenoma * * Jung Shin JUNG Shin * Departments of Neurosurgery ... Supra-diaphragmatic Pituitary Adenoma Removed Through the Trans-tuberculum Sellae Approach : Case Report KINOSHITA Yasuyuki , ...
429 patients (acromegaly 72%, Cushings disease 13%, chromophobe adenoma 8%, prolactin-secreting adenoma 4%, Nelsons syndrome ... 16 women, prolactin-secreting adenoma. Narrow beam proton therapy (1000 MeV) 40-120 Gy. Tested 2 month-2 years with IV TRH and ... ITEP, Russia; 1983 PMID 6314085 -- "[Proton therapy of pituitary adenomas][Article in Russian]" (Minakova EI, Med Radiol (Mosk ... Loma Linda; 2006 (1991-2001) PMID 16257131 -- "Fractionated proton beam irradiation of pituitary adenomas." (Ronson BB, Int J ...
Chang CH, Pool JL (1967) The radiotherapy of pituitary chromophobe adenomas: an evaluation of indication, technic, and result. ... Pituitary fibrosarcoma secondary to radiation therapy for the treatment of chromophobe adenoma (authors transl). No Shinkei ... Boelaert K, Gittoes NJ (2001) Radiotherapy for non-functioning pituitary adenomas. Eur J Endocrinol 144:569-575CrossRefPubMed ... Fisher BJ, Gaspar LE, Noone B (1993) Radiation therapy of pituitary adenoma: delayed sequelae. Radiology 187:843-846PubMed ...
These techniques have identified hormonal production in many chromophobe adenomas, enabling pathologists to identify hormones ... AIP mutation in pituitary adenomas in the 18th century and today. N Engl J Med. 2011 Jan 6. 364(1):43-50. [Medline]. ... Treatment of pituitary adenomas by fractionated stereotactic radiotherapy: a prospective study of 110 patients. Int J Radiat ... Castinetti F, Régis J, Dufour H, Brue T. Role of stereotactic radiosurgery in the management of pituitary adenomas. Nat Rev ...
size of papillary adenoma was 5 mm. From now, papillary adenoma is de?ned as a papillary renal tumour =15 mm in ... The main prognostic factors in chromophobe RCC are tumour stage, the presence of necrosis, a sarcomatoid and/or ... Hybrid tumours present overlapping features of oncocyto- mas and chromophobe RCC. They have indolent behaviour ...
The 17 patients studied include cases of pituitary or parapituitary tumors (chromophobe adenomas, craniopharyngiomas) and ...
The most frequently observed neoplasms were pituitary chromophobe adenomas, adrenal phaeochromocytomas, and tumours of the ...
A nonfunctional adenoma of the adrenal or pituitary gland. Endocrine-inactive tumors were formerly known as chromophobe ... adenomas. They are the most commonly detected neoplasms of the pituitary gland. ...
During this time, he wrote his first book, in collaboration with John Nurnberger, called Pituitary Chromophobe Adenomas: ...
Adenoma, Chromophobe, complications, Adult, Female, Follow-Up Studies, Fundus Oculi, Humans, Middle Aged, Nerve Compression ... The same factors were studied prior to surgery in six patients with compression of the chiasm due to chromophobe adenoma. In ...
  • Villwock et al noted that pituitary tumors constitute 10-15% of all diagnosed intracranial tumors, 90% of which are adenomas. (medscape.com)
  • G-protein abnormalities, ras gene mutations, p53 gene deletions, mutations, and rearrangements, and the association of pituitary tumors with the syndrome of multiple endocrine neoplasia have been described and are involved in the development of adenomas in the pituitary gland. (medscape.com)
  • [ 4 ] Nonfunctioning adenomas are associated with hypermethylation of p16 prolactinomas, and corticotropin-secreting tumors express galectin-3 (Gal-3), a gene involved in cell growth and apoptosis. (medscape.com)
  • The 17 patients studied include cases of pituitary or parapituitary tumors (chromophobe adenomas, craniopharyngiomas) and nontumor cases (table 1). (annals.org)
  • Most pituitary tumors are adenomas. (merckmanuals.com)
  • Most tumors of the pituitary and suprasellar region are pituitary adenomas. (merckmanuals.com)
  • Most pituitary tumors are adenomas, which may be secretory or nonsecretory. (merckmanuals.com)
  • BHD is associated with a variety of histologic types of renal tumors, including chromophobe renal cell carcinoma (RCC), benign renal oncocytoma, clear-cell RCC and papillary type I RCC. (abcam.com)
  • Rapid uptake of the calcium analog manganese (Mn 2+ ) into spontaneous pituitary adenoma during MR imaging of aged rats generated the hypothesis that neuroendocrine tumors may have a corresponding increase in calcium influx required to trigger hormonal release. (ajnr.org)
  • These results indicate that adenomas have increased activity-dependent calcium influx compared with normal aged pituitary glands, suggesting a potential for exploitation in the clinical work-up of pituitary and other neuroendocrine tumors by developing Mn-MR imaging for humans. (ajnr.org)
  • In addition, many pituitary tumors previously believed to be non-functional or "chromophobe adenomas" appear to be prolactinomas. (elsevier.com)
  • Tumors that produce hormones are functional or secretory , while those that don't are non-functional, non-secretory or chromophobe adenomas . (greek.doctor)
  • Surgical strategies for removal of pituitary adenoma: The pituitary tumors could be taken out by the transfrontal surgery or by the trans-sphenoidal route. (earthslab.com)
  • A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (curehunter.com)
  • Immunohistochemical identification of intracytoplasmic lumens by cytokeratin typing may differentiate renal oncocytoma from chromophobe renal cell carcinoma'Histology and Histopathology. (nii.ac.jp)
  • and three benign forms-metanephric adenoma (adenofibroma), papillary renal cell adenoma, and oncocytoma. (renalandurologynews.com)
  • Thus, we conclude that MN/CA9 protein expression could serve as a valuable adjunct to the cytological and histological diagnosis of benign renal cysts versus cystic RCC, adenoma versus RCC, and oncocytoma versus granular cell RCC. (aacrjournals.org)
  • Purpose: To investigate and distinguish the computed tomography (CT) characteristics of chromophobe renal cell carcinoma (chRCC) and renal oncocytoma. (elsevier.com)
  • A benign tumor , or adenoma , that usually results in the excess production of adrenal gland hormones. (cushings-help.com)
  • Adenomas that produce prolactin are treated with dopaminergic agonists (eg, bromocriptine , pergolide, cabergoline ), which lower blood levels and often shrink the tumor. (merckmanuals.com)
  • 5 histopathologic diagnoses submitted by mail on two cases of ependymoma included malignant choroid plexus tumor, chromophobe adenoma, angiosarcoma, medulloblastoma, and 20 "others. (thejns.org)
  • The adenomas tend to beige- to white colored small tumor masses whereas the carcinomas show an extensive greasy-brown colored central necrosis resulting from consecutive hemorrhages. (atlasgeneticsoncology.org)
  • Although she experienced no clinical features associated with spontaneous infarction of a pituitary tumor, plasma ACTH levels fell to 474-575 pg/ml, and hemorrhagic necrosis was found in a 5-mm chromophobe adenoma at transsphenoidal surgery. (nih.gov)
  • Rats with adenomas received fluorodeoxyglucose-positron-emission tomography (FDG-PET) scanning for characterization of tumor metabolism. (ajnr.org)
  • The discovery of rapid uptake of Mn 2+ into the adenomas led us to hypothesize that pituitary adenoma would show increased calcium influx, which could be used as an index of tumor activity. (ajnr.org)
  • The commonest tumor of the pituitary gland is adenoma originating from its chromophobe cells. (earthslab.com)
  • Cheville JC, Lohse CM, Sukov WR et al (2012) Chromophobe renal cell carcinoma: the impact of tumor grade on outcome. (springer.com)
  • The fairly recently described chromophobe variant of renal cell carcinoma (I've seen them in study slide sets, but never one on the hoof) indeed is supposed to mark very strongly with colloidal iron. (histosearch.com)
  • Cindolo L, de la Taille A, Schips L et al (2005) Chromophobe renal cell carcinoma: comprehensive analysis of 104 cases from multicenter European database. (springer.com)
  • The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. (ucdenver.edu)
  • Papillary RCC can be devided in adenomas and carcinomas. (atlasgeneticsoncology.org)
  • Journal Article] Immunohistochemical identification of intracytoplasmic lumens by cytokeratin typing may differentiate renal oncocytomas from chromophobe renal cell carcinomas. (nii.ac.jp)
  • Plurihormonal adenomas (which produce more than one hormone) and pituitary carcinomas are very rare. (greek.doctor)
  • Visual disturbances are much less frequent in functional adenomas, where systemic hormonal aberrations such as Cushing's syndrome, galactorrhea, and acromegaly usually predate the compressive signs [ 2 ]. (intechopen.com)
  • eg, acidophilic adenomas overproduce growth hormone, and basophilic adenomas overproduce adrenocorticotropic hormone (ACTH). (merckmanuals.com)
  • The present study demonstrated various age-associated lesions of the PD and PN and revealed a high frequency of incidental, non-PPID-associated PI adenomas in aged horses. (uni-muenchen.de)
  • Headache may result from an enlarging pituitary adenoma, even when intracranial pressure is not increased. (merckmanuals.com)
  • Brain magnetic resonance imaging showed two bilateral abscesses in the fronto-parietal areas with intracranial venous sinus thrombosis and a pituitary adenoma that extended from the suprasellar region, eroding the sellar floor into the sphenoid sinus. (revistaneurocirugia.com)
  • It is advisable to include pituitary adenoma in the differential diagnosis of meningitis even though its onset as intracranial abscess and rectus sinus thrombosis is extremely rare. (revistaneurocirugia.com)
  • Anterior lobe adenomas comprise about 10% of all intracranial tumours (posterior lobe adenomas do Secretion of the pituitary hormones is regulated by not occur). (slideshare.net)
  • Chiasmal syndromes most commonly occur secondary to pituitary adenomas, craniopharyngiomas, meningiomas, and pituitary apoplexy. (intechopen.com)
  • Dogs and cats with nonfunctional adenomas develop clinical disturbances related to a lack of secretion of pituitary trophic hormones and diminished target organ function or to dysfunction of the CNS. (msdvetmanual.com)
  • Thyroid glands in dogs and cats with large pituitary adenomas often are smaller than normal, although to a much lesser degree than the adrenal cortex. (msdvetmanual.com)
  • Computerized searches identified an "effectiveness population", including 115 adults with acroGHD and a control population of age, gender and body mass index (BMI) - matched patients, consisting of 142 adults with GHD and history of clinically non-functioning pituitary adenoma (NFPA). (harvard.edu)
  • PI adenomas were observed in 18% (22/124) of the animals, but only four horses were evidently suffering from PPID, therefore clinically overt/PPID-associated PI adenomas were found in 3% (4/124) of all horses. (uni-muenchen.de)
  • 13 , 14 Pituitary adenomas may manifest clinically by hormonal hypersecretion, which is dependent on increased activity-dependent calcium influx. (ajnr.org)
  • To the best of the author's knowledge, cluster headache associated with a clinically non-functioning pituitary adenoma (chromophobe adenoma) has not been described. (biomedcentral.com)
  • This case report describes the case of a man with cluster headache where the evaluation showed a clinically non-functioning pituitary adenoma. (biomedcentral.com)
  • Further evaluations including hormonal screening revealed a clinically non-functioning pituitary adenoma (chromophobe adenoma). (biomedcentral.com)
  • A clinically non-functioning pituitary adenoma can present as cluster headache. (biomedcentral.com)
  • CH associated with a clinically non-functioning pituitary adenoma (chromophobe adenoma) has not been described. (biomedcentral.com)
  • This case report describes a man with typical CH in the setting of a clinically non-functioning pituitary adenoma. (biomedcentral.com)
  • This cooperation between the nervous system and Effects of pituitary adenomas endocrine apparatus is referred to as neuroendocrine Pituitary adenomas cause problems because of a com- signalling. (slideshare.net)
  • This lobe is in direct continuity with the hypothalamus, to which it is Anterior lobe adenomas connected via the pituitary stalk. (slideshare.net)
  • An adenoma of the chromophobe cells of the anterior pituitary gland. (dictionary.com)
  • It's called chromophobe because it looks like the chromophobe adenoma of the anterior pituitary. (histosearch.com)
  • The most common cause of hyperpituitarism (increased level of one or more pituitary hormones) is a functional anterior lobe pituitary adenoma. (greek.doctor)
  • The exact symptom of an anterior pituitary adenoma depends on which hormone it produces. (greek.doctor)
  • adenomas of the anterior lobe. (slideshare.net)
  • Chromophobe Adenoma, also known as adenoma, chromophobe , is related to adenoma and galactorrhea . (malacards.org)
  • Metanephric adenoma: primitive appearing blue cells, WT1+. (auanet.org)
  • After surgical removal of the pituitary chromophobe adenoma, T 4 levels returned to normal (6.8 μg/dL) and TSH levels improved substantially (9.0 μU/mL). (jamanetwork.com)
  • Pituitary adenoma generates 2 types of symptoms: (a) symptoms because of pressure on adjacent structures and (b) symptoms because of endocrine disruptions. (earthslab.com)
  • M8140/0) Adenoma, NOS M8140/1 Atypical adenoma Bronchial adenoma, NOS (C34. (wikipedia.org)
  • 0.001) and focal hyperplasia of chromophobes in the PD and age. (uni-muenchen.de)
  • plurihormonal adenoma with growth hormone production. (curehunter.com)
  • Multiple lipomas, angiolipomas, and parathyroid adenomas are also seen in patients affected with this disease. (abcam.com)
  • Clear cell and papillary RCC subtypes are both derived from the proximal tubule cells whereas chromophobe RCC is derived from collecting duct intercalated cells in the renal cortex. (renalandurologynews.com)
  • Mn 2+ influx was characterized in cultured pituitary adenoma cells. (ajnr.org)
  • An adenoma composed of cells that stain readily. (dictionary.com)
  • Parakeets with chromophobe adenomas often develop exophthalmos due to extension of neoplastic cells along the optic nerve. (msdvetmanual.com)
  • The presumptive diagnosis was pituitary adenoma with hemorrhage, perhaps related to her heparin requirement, leading to visual loss. (harvard.edu)
  • Current clinical work-up for diagnosis and treatment of different types of pituitary adenomas usually includes MR imaging with or without gadolinium contrast enhancement. (ajnr.org)
  • Amine AR, Sugar O (1976) Suprasellar osteogenic sarcoma following radiation for pituitary adenoma. (springer.com)
  • Boelaert K, Gittoes NJ (2001) Radiotherapy for non-functioning pituitary adenomas. (springer.com)
  • Brada M, Ford D, Ashley S, Bliss JM, Crowley S, Mason M, Rajan B, Traish D (1992) Risk of second brain tumour after conservative surgery and radiotherapy for pituitary adenoma. (springer.com)
  • Chang CH, Pool JL (1967) The radiotherapy of pituitary chromophobe adenomas: an evaluation of indication, technic, and result. (springer.com)