Focal Nodular Hyperplasia: Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. The nodule, poorly encapsulated, consists of a central stellate fibrous scar and normal liver elements such as HEPATOCYTES, small BILE DUCTS, and KUPFFER CELLS among the intervening fibrous septa. The pale colored central scar represents large blood vessels with hyperplastic fibromuscular layer and narrowing lumen.Bile Ducts, Intrahepatic: Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.Adenoma: A benign epithelial tumor with a glandular organization.Cholangiocarcinoma: A malignant tumor arising from the epithelium of the BILE DUCTS.Bile Ducts: The channels that collect and transport the bile secretion from the BILE CANALICULI, the smallest branch of the BILIARY TRACT in the LIVER, through the bile ductules, the bile ducts out the liver, and to the GALLBLADDER for storage.Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Hemangioma: A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)Adenoma, Liver Cell: A benign epithelial tumor of the LIVER.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Common Bile Duct: The largest bile duct. It is formed by the junction of the CYSTIC DUCT and the COMMON HEPATIC DUCT.Adenoma, Liver Cell: A benign epithelial tumor of the LIVER.Liver Neoplasms: Tumors or cancer of the LIVER.Focal Nodular Hyperplasia: Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. The nodule, poorly encapsulated, consists of a central stellate fibrous scar and normal liver elements such as HEPATOCYTES, small BILE DUCTS, and KUPFFER CELLS among the intervening fibrous septa. The pale colored central scar represents large blood vessels with hyperplastic fibromuscular layer and narrowing lumen.Liver Diseases: Pathological processes of the LIVER.Granuloma: A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Hemangioma: A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)Hepatectomy: Excision of all or part of the liver. (Dorland, 28th ed)Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Liver Regeneration: Repair or renewal of hepatic tissue.Cysts: Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.Hepatomegaly: Enlargement of the liver.Liver Diseases: Pathological processes of the LIVER.Granuloma: A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Liver Neoplasms: Tumors or cancer of the LIVER.Liver Regeneration: Repair or renewal of hepatic tissue.Polycystic Kidney Diseases: Hereditary diseases that are characterized by the progressive expansion of a large number of tightly packed CYSTS within the KIDNEYS. They include diseases with autosomal dominant and autosomal recessive inheritance.Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Hepatectomy: Excision of all or part of the liver. (Dorland, 28th ed)Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.Liver Neoplasms: Tumors or cancer of the LIVER.Hypertension, Portal: Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.Liver Diseases: Pathological processes of the LIVER.Hepatectomy: Excision of all or part of the liver. (Dorland, 28th ed)Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Portal Vein: A short thick vein formed by union of the superior mesenteric vein and the splenic vein.Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Knowledge Bases: Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).Herpesvirus 2, Gallid: The type species of the genus MARDIVIRUS in the family HERPESVIRIDAE. It is the etiologic agent of MAREK DISEASE, infecting domestic fowl and wild birds.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Scientific Misconduct: Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Game Theory: Theoretical construct used in applied mathematics to analyze certain situations in which there is an interplay between parties that may have similar, opposed, or mixed interests. In a typical game, decision-making "players," who each have their own goals, try to gain advantage over the other parties by anticipating each other's decisions; the game is finally resolved as a consequence of the players' decisions.Dominica: An island republic of the West Indies. Its capital is Roseau. It was discovered in 1493 by Columbus and held at different times by the French and the British in the 18th century. A member of the West Indies Federation, it achieved internal self-government in 1967 but became independent in 1978. It was named by Columbus who discovered it on Sunday, Domingo in Spanish, from the Latin Dominica dies, the Lord's Day. (From Webster's New Geographical Dictionary, 1988, p338 & Room, Brewer's Dictionary of Names, 1992, p151)Cooperative Behavior: The interaction of two or more persons or organizations directed toward a common goal which is mutually beneficial. An act or instance of working or acting together for a common purpose or benefit, i.e., joint action. (From Random House Dictionary Unabridged, 2d ed)Expert Systems: Computer programs based on knowledge developed from consultation with experts on a problem, and the processing and/or formalizing of this knowledge using these programs in such a manner that the problems may be solved.
(1/118) Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine.

The modifying effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a mutagenic by-product in chlorinated water, on the development of glandular stomach cancers were investigated in Wistar rats. A total of 120 males, 6 weeks of age, were divided into six groups. After initiation with 100 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) solution and 5% NaCl diet for 8 weeks, 30 rats each in groups 1-3 were given MX in the drinking water at concentrations of 30, 10, or 0 ppm for the following 57 weeks. Ten animals each in groups 4-6 were administered the MX without prior carcinogen exposure. There were no statistical significant differences in final body weights between the groups. The incidences and multiplicities of adenocarcinomas in the glandular stomachs were significantly higher (P < 0.05) in the initiated 30 ppm MX group than those in the MNNG/NaCl group. The incidences of atypical hyperplasias in the glandular stomachs were also significantly increased (P < 0.05 or 0.01) by the MX treatments. With their multiplicity, the effects were clearly dose dependent. Interestingly, the 30 ppm MX alone itself induced atypical hyperplasias in the pylorus, although the incidences and severity were low. Moreover, MX showed a tendency to enhance the development of intrahepatic cholangiocellular tumors and thyroid follicular cell tumors in the MNNG-treated animals. The results of the present study thus indicate that MX exerts promoting effects when given during the postinitiation phase of two-stage glandular stomach carcinogenesis in rats.  (+info)

(2/118) Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine.

Human liver cancers have been associated mainly with chronic inflammations such as viral hepatitis B or C. This suggests that prolonged cell damage by chronic inflammation is critical in cancer development. Overproduction of nitric oxide (NO.) and its derivative (NOx, peroxynitrite) has been implicated as a cause of tissue damage by inflammation, thus contributing to tumor promotion. We have demonstrated the expression of the inducible isoform of nitric oxide synthase (iNOS) and 3-nitrotyrosine, a marker of peroxynitrite formation, by immunohistochemistry in preneoplastic and neoplastic rat liver tissues induced by continuous infusion of N-nitrosodiethylamine with mini-pumps. The preneoplastic lesions were characterized by proliferation of phenotypically altered hepatic foci (PAHF), dysplastic hepatocytes and oval cells. Histologically, the tumors were hepatocellular carcinomas (HCCs) of trabecular, (pseudo)glandular and solid types with or without cholangiocellular involvement. iNOS was located mainly in oval cells, capillary endothelial and muscular cells, epithelia of cholangiomas and glandular HCCs. 3-Nitrotyrosine was observed in the cytoplasms of PAHF and dysplastic hepatocytes in preneoplasias and in the cytoplasms of some living or apoptotic HCC cells, connective tissues, proteinaceous fluids, sinusoidal endothelia of tumorous hepatocytes and cholangiomas in tumors. From these observations, we suggest that: (i) chronic tissue damage by chemical carcinogens may act to induce iNOS and peroxynitrite formation; (ii) oval cells play a key role in development and/or growth of tumor tissues by producing NO. via iNOS, which may also cause tissue damage by peroxynitrite; (iii) iNOS can be considered as a phenotypic marker in cells of oval cell lineage and neovascularized capillaries in tumor tissues.  (+info)

(3/118) Primary liver carcinoma in genetic hemochromatosis reveals a broad histologic spectrum.

Hepatocellular carcinoma (HCC) is a well-known complication of genetic hemochromatosis (GH). However, the frequency of primary liver carcinoma (PLC) with biliary differentiation, such as cholangiocarcinoma (CC) and combined hepatocholangiocarcinoma (CHCC), in GH remains unclear We analyzed the histologic type of 20 PLCs occurring in the background of GH; all patients were homozygotic for the C282Y mutation. Ten were depleted of iron by successive phlebotomies, while the remaining 10 were untreated. Histologically, 13 cases were classified as HCC, 3 as CC, and 4 as CHCC. Immunohistochemical detection of Hep Par 1, cytokeratin 19 (CK19), and MUC1 supported this classification; PLC with biliary differentiation was immunoreactive for MUC1 in 86% (6/7) of cases and for CK19 in 100% (7/7) of cases. The nontumoral liver exhibited no cirrhosis or extensive fibrosis in 6 cases. Von Meyenburg complexes were present in 11 cases and intraparenchymal bile duct adenomas in 3. These data suggest that PLCs in patients with GH present a wide histologic spectrum, with tumors showing frequent biliary differentiation; may arise on a nonfibrotic or a cirrhotic liver; and often are associated with Von Meyenburg complexes and to a lesser extent with bile duct adenomas.  (+info)

(4/118) Management strategies in resection for hilar cholangiocarcinoma.

Between 1960 and 1990, resection was performed in 23 of 122 patients who underwent surgical treatment for hilar cholangiocarcinoma. Local excision of the lesion alone was performed in 10 cases (43%). Hepatic resection for tumor extending to the secondary bile ducts or hepatic parenchyma was performed in 13 cases (57%): extended right hepatectomy (3), right hepatectomy (1), extended left hepatectomy (6), left hepatectomy (2), and left lobectectomy (1). In three other cases, resection by total hepatectomy and liver transplantation was performed, but these were not included in the analysis of results for resection. Significant operative complications occurred in only two cases (8.7%), and the operative mortality rate was zero. In four cases, complete excision of the tumor could not be achieved macroscopically (macroscopic curative resection rate 19/122; 15.6%). In nine cases, the margins of the resected specimens were free from tumor on histologic examination (microscopic curative resection rate, 9/122; 7.4%). In 10 cases, the resection margins were found to contain tumor on histologic examination. The overall survival rate was 87% at 1 year, 63% at 2 years, and 25% at 3 years (median survival, 24 months). The survival and freedom from recurrence rates for patients with free resection margins was superior to that for patients with involved resection margins or residual macroscopic disease. A potentially curative resection, with histologically negative margins and no recurrence to date, was achieved in seven patients using the following procedures: local excision for two type I lesions; left hepatectomy plus excision of segment 1 for two type IIIb lesions and one type IV lesion; right hepatectomy and right hepatectomy plus excision of segment 1 for two type IIIa lesions. These results indicate that improved survival in hilar cholangiocarcinoma can be achieved by resection, with minimal morbidity and zero mortality rates, if histologically free resection margins are obtained. To achieve this, we recommend the following procedures for each type of lesion, based on our experience and on anatomic considerations: local excision for type I; local excision plus resection of segment 1 for type II; local excision, resection of segment 1, and right or left hepatectomy for types IIIa and b; hepatectomy plus liver transplantation for type IV.  (+info)

(5/118) Low frequency of p53 gene mutation in tumors induced by aflatoxin B1 in nonhuman primates.

Aflatoxin B1 has been suggested as a causative agent for a G to T mutation at codon 249 in the p53 gene in human hepatocellular carcinomas from southern Africa and Qidong in China. To test this hypothesis, nine tumors induced by aflatoxin B1 in nonhuman primates were analyzed for mutations in the p53 gene. These included four hepatocellular carcinomas, two cholangiocarcinomas, a spindle cell carcinoma of the bile duct, a hemangioendothelial sarcoma of the liver, and an osteogenic sarcoma of the tibia. None of the tumors showed changes at the third position of codon 249 by cleavage analysis of the HaeIII enzyme site at codon 249. A point mutation was identified in one hepatocellular carcinoma at the second position of codon 175 (G to T transversion) by sequencing analysis of the four conserved domains (II to V) in the p53 gene. These data suggest that mutations in the p53 gene are not necessary in aflatoxin B1 induced hepatocarcinogenesis in nonhuman primates. The occurrence of mutation in codon 249 of the p53 gene in selective samples of human hepatocellular cancers may indicate involvement of environmental carcinogens other than aflatoxin B1 or that hepatitis B virus-related hepatitis is a prerequisite for aflatoxin B1 induction of G to T transversion in codon 249.  (+info)

(6/118) Evaluation of liver tumors using fluorine-18-fluorodeoxyglucose PET: characterization of tumor and assessment of effect of treatment.

To evaluate glucose metabolism in patients with tumors involving the liver, 35 patients with liver lesions had PET using 18F-2-fluoro-2-deoxy-D-glucose (FDG). FDG (148 MBq) was injected and radioactivity of the tumor was scanned dynamically by PET. The rate constants (k1, k2, k3, k4) of FDG in a metabolic model were calculated. The results were compared to hexokinase activity in the excised tumor specimens. k3 was found to reflect tumor hexokinase activity. When k3 was used as an index (cut-off value: 0.025), it was possible to distinguish benign and malignant tumors. k4 was significantly higher in hepatocellular carcinoma. By using k3 and k4 as indices, one could assess the degree of differentiation of hepatocellular carcinoma. After treatment, k3 decreased according to the effectiveness of therapy and thus may be a useful index for quantitatively assessing tumor viability.  (+info)

(7/118) Analysis of failure after curative irradiation of extrahepatic bile duct carcinoma.

Thirty-four patients with subtotally resected or unresectable carcinoma of the extrahepatic bile ducts received radiation therapy; a minimum of 45 Gy (external beam) to the tumor and regional lymph nodes +/- 5-fluorouracil (5-FU). Seventeen patients received an external beam boost of 5 to 15 Gy to the tumor, and a specialized boost was used in the remaining 17 patients (iridium-192 transcatheter seeds in 10 and intraoperative radiation therapy [IORT] with electrons in seven). The median time to death in all 34 patients was 12 months (range, 4 to 98-months). The only patients who survived longer than 18 months were those either with gross total or subtotal resection before external irradiation (2 of 6) or who received specialized boosts (192Ir, 3 of 10; IORT, 3 of 7). Local failure was documented in 9 of 17 patients who received external beam irradiation alone +/- 5-FU, 3 of 10 patients who received an 192Ir boost, and 2 of 6 patients who received an IORT boost with curative intent.  (+info)

(8/118) Clinical evaluation of a new serum tumour marker CA 242 in pancreatic carcinoma.

The aim of this study was to evaluate the new monoclonal tumour marker CA 242 in the diagnosis of pancreatic carcinoma and to compare it with the established markers CA 50 and CEA. Serum concentrations were determined in 113 patients with jaundice, in 20 patients with laboratory values suggesting cholestasis, and in 60 patients with a suspicion to have chronic pancreatitis. Twenty-four of these 193 patients had pancreatic carcinoma and two patients had carcinoma of papilla of Vater. The sensitivities of CA 242, CA 50 and CEA were 80.7%, 96.1%, and 92.3%, respectively. The specificities were 79.0%, 58.0%, and 59.2%. The sensitivities of combinations of CA 50 and CEA with CA 242 did not exceed the sensitivity of CA 50 alone. The specificity of CA 242 was improved by combining it with CEA (92.2%). The serum marker CA 242 seems to be less sensitive than CEA and CA 50 in the detection of pancreatic carcinoma, but it may prove useful because of its high specificity.  (+info)

*  International Classification of Diseases for Oncology
... malignant M8160/0 Bile duct adenoma (C22.1, C24.0) Cholangioma (M8160/3) Cholangiocarcinoma (C22.1, C24.0) Bile duct carcinoma ... benign Mesonephric adenoma Wolffian duct adenoma M9110/1 Mesonephric tumor, NOS Wolffian duct tumor M9110/3 Mesonephroma, ... Black adenoma Pigmented adenoma M8373/0 Adrenal cortical adenoma, clear cell (C74.0) M8374/0 Adrenal cortical adenoma, ... Infiltrating duct adenocarcinoma Duct adenocarcinoma, NOS Duct carcinoma, NOS Duct cell carcinoma Ductal carcinoma, NOS M8501/2 ...
*  List of hepato-biliary diseases
Malignant neoplasm of liver and intrahepatic bile ducts. The most frequent forms are metastatic malignant neoplasm of liver) ... hepatic adenomas, and focal nodular hyperplasia (FNH). Chronic liver diseases like chronic hepatitis, chronic alcohol abuse or ... of liver malignant neoplasm of the gallbladder malignant neoplasm of other parts of biliary tract extrahepatic bile duct ...
*  List of MeSH codes (C04)
... adenoma, acidophil MeSH C04.557.470.035.075 --- adenoma, basophil MeSH C04.557.470.035.085 --- adenoma, bile duct MeSH C04.557. ... bile duct neoplasms MeSH C04.588.274.120.250.250 --- common bile duct neoplasms MeSH C04.588.274.120.401 --- gallbladder ... adenoma, liver cell MeSH C04.557.470.035.140 --- adenoma, oxyphilic MeSH C04.557.470.035.155 --- adenoma, pleomorphic MeSH ... adenoma, acidophil MeSH C04.557.465.625.650.075 --- adenoma, basophil MeSH C04.557.465.625.650.095 --- adenoma, chromophobe ...
*  Cystadenoma
Bile duct cystadenoma (8161) Endometrioid cystadenoma (8380) Appendiceal mucinous cystadenoma The term "cystadenoma" may also ... Cystadenoma (or "cystoma") is a type of cystic adenoma. When malignant, it is called cystadenocarcinoma. When not otherwise ...
*  List of cancer types
... gastrointestinal Colon cancer Extrahepatic bile duct cancer Gallbladder cancer Gastric (stomach) cancer Gastrointestinal ... Bronchial adenomas/carcinoids Small cell lung cancer Mesothelioma Non-small cell lung cancer Pleuropulmonary blastoma Laryngeal ... which suggests that it has originated in the milk ducts.[citation needed] Benign tumors (which are not cancers) are usually ... Cerebral astrocytoma malignant glioma Medulloblastoma Neuroblastoma Oligodendroglioma Pineal astrocytoma Pituitary adenoma ...
*  Liver cancer
... can also form from other structures within the liver such as the bile duct, blood vessels and immune cells. Cancer ... which is a misnomer because adenomas are usually benign). HCC is a cancer formed by liver cells, known as hepatocytes, that ... The majority of cholangiocarcimas occur in the hilar region of the liver, and often present as bile duct obstruction. If the ... "SEER Stat Fact Sheets: Liver and Intrahepatic Bile Duct Cancer". NCI. Archived from the original on 2017-07-28. Retrieved 2016 ...
*  ICD-10 Chapter II: Neoplasms
Liver Intrahepatic bile ducts (D13.5) Extrahepatic bile ducts (D13.6) Pancreas (D13.7) Endocrine pancreas Islet cell tumour ... Pituitary gland Pituitary adenoma Prolactinoma (D35.3) Craniopharyngeal duct (D35.4) Pineal gland (D35.5) Carotid body (D35.6) ... Malignant neoplasms of liver and intrahepatic bile ducts (C22.0) Liver cell carcinoma (C22.1) Intrahepatic bile duct carcinoma ... Lacrimal gland and duct (C69.6) Orbit (C69.7) Overlapping lesion of eye and adnexa (C70) Malignant neoplasm of meninges (C70.0 ...
*  Hepatotoxicity
Injury to hepatocyte and bile duct cells lead to accumulation of bile acid inside the liver. This promotes further liver damage ... Hepatocellular carcinoma, angiosarcoma, and liver adenomas are the ones usually reported. Causes: Vinyl chloride, combined oral ... it can produce features similar to primary biliary cirrhosis due to progressive destruction of small bile ducts (Vanishing duct ... diclofenac Cholestasis Liver injury leads to impairment of bile flow and cases are predominated by itching and jaundice. ...
*  List of MeSH codes (C06)
... common bile duct neoplasms MeSH C06.130.320.120 --- bile duct neoplasms MeSH C06.130.320.120.280 --- common bile duct neoplasms ... adenoma, islet cell MeSH C06.301.761.249.500 --- insulinoma MeSH C06.301.761.500 --- carcinoma, islet cell MeSH C06.301.761.500 ... File "2006 MeSH Trees".) MeSH C06.130.120.120 --- bile duct neoplasms MeSH C06.130.120.120.280 --- common bile duct neoplasms ... bile duct neoplasms MeSH C06.301.120.250.250 --- common bile duct neoplasms MeSH C06.301.120.401 --- gallbladder neoplasms MeSH ...
*  Liver tumor
The majority of cholangiocarcimas occur in the hilar region of the liver, and often present as bile duct obstruction. If the ... The size of adenomas range from 1 to 30 cm. Symptoms associated with hepatic adenomas are all associate with large lesions ... Hepatic adenomas: These benign epithelial liver tumors develop in the liver and are also an uncommon occurrence, found mainly ... Over the last few decades there has been an increase with occurrences of this specific type of adenoma. The prognosis for these ...
*  Scintigraphy
... of the biliary system is called cholescintigraphy and is done to diagnose obstruction of the bile ducts by a ... Tc99m-sestamibi is used to detect parathyroid adenomas. To detect metastases/function of thyroid, the isotopes iodine-131 or ... The radiopharmaceutical then goes into the bile ducts, the gallbladder, and the intestines. The gamma camera is placed on the ... It can also diagnose gallbladder diseases, e.g. bile leaks of biliary fistulas. In cholescintigraphy, the injected radioactive ...
*  Liver function tests
Bile duct obstruction by gallstones, hepatitis, cirrhosis or cancer should be suspected. About 5% of the population has ... parathyroid adenoma, hyperplasia, or secondary hyperparathyroidism from vitamin D deficiency or renal disease), 4) in cases of ... Obstruction can be located either within the liver or in the bile duct). The diagnosis is narrowed down further by evaluating ... ALP levels in plasma rise with large bile duct obstruction, intrahepatic cholestasis, or infiltrative diseases of the liver. ...
*  Pancreatic serous cystadenoma
... a yellowing of the skin and eyes caused by obstruction of the bile duct), or weight loss. These signs and symptoms are not ... Pancreatic serous cystadenoma, also known as serous cystadenoma of the pancreas and serous microcystic adenoma, a benign tumour ... The cysts do not communicate with the larger pancreatic ducts. In some cases a fine needle aspiration (FNA) biopsy can be ...
*  Adenocarcinoma
Cholangiocarcinoma, or bile duct cancer Vaginal cancer Cancer of the urachus Stomach cancer Prostate Cancer The term ... Next, they suggested that k-Ras becomes activated and the polyp becomes a small, benign adenoma. The adenoma, lacking the " ... Adenocarcinoma is the malignant counterpart to adenoma, which is the benign form of such tumors. Sometimes adenomas transform ... The gastroenterologist uses a colonoscopy to find and remove these adenomas and polyps to prevent them from continuing to ...
*  Pseudomyxoma peritonei
Other primary sites that have been reported include colon, rectum, stomach, gallbladder, bile ducts, small intestine, urinary ... 2007) argued that continued use of non-malignant terms, i.e., adenoma, for those frequent cases with low-grade features (such ... Bradley states that an adenoma, by definition, is a tumor confined to the appendiceal mucosa with absolutely no evidence of ... proposed separating pseudomyxoma peritonei cases into two diagnostic categories: adenoma (disseminated peritoneal ...
*  Hereditary nonpolyposis colorectal cancer
... bile duct or pancreatic), urinary tract cancers, prostate cancer and brain tumours were as follows: for MLH1 mutations the risk ... Colorectal cancer Endometrial carcinoma Digestive adenoma: gastric adenoma, pyloric gland adenoma, duodenal adenoma, intestinal ... "Pyloric gland adenoma in Lynch syndrome". The American Journal of Surgical Pathology. 38 (6): 784-92. doi:10.1097/PAS. ... adenoma Ovarian serous cystadenocarcinoma Individuals with HNPCC have about an 80% lifetime risk for colon cancer. Two-thirds ...
*  Bile acid
... a bile acid-sensitive ion channel highly expressed in bile ducts". FASEB J. 26 (10): 4122-30. doi:10.1096/fj.12-207043. PMID ... Genetic variation in the key bile acid synthesis enzyme, CYP7A1, influenced the effectiveness of UDCA in colorectal adenoma ... The bile acid pool size is between 4-6 g, which means that bile acids are recycled several times each day. About 95% of bile ... This condition of bile acid diarrhea/bile acid malabsorption can be diagnosed by the SeHCAT test and treated with bile acid ...
*  Riddelliine
... and bile duct proliferation. Senecionine, a closely related pyrrolizidine alkaloid Adams, I. Roger; Hamlin, K. E., Jr.; Jelinek ... In rats, oral administration led to an increase in haemangiosarcomas in the liver, cellular carcinomas and/or adenomas in the ... In mice, oral administration led to haemangiosracomas in the liver in males and to broncho-alveolar adenomas and carcinomas in ...
*  Index of oncology articles
... common bile duct - comorbidity - compassionate use trial - complementary and alternative medicine - complete blood count (CBC ... tubulovillous adenoma - tumor - tumor antigen vaccine - tumor board review - tumor burden - tumor debulking - tumor ... bile duct - biliary - bilirubin - binding agent - bioavailable - biochanin A - biochemical reactions - biological response ... intrahepatic bile ducts - intrahepatic infusion - intralesional - intraluminal intubation and dilation - Intramuscular ...
*  List of ICD-9 codes 140-239: neoplasms
Malignant neoplasm of liver and intrahepatic bile ducts (156) Malignant neoplasm of gallbladder and extrahepatic bile ducts ( ... Pituitary gland and craniopharyngeal duct Pituitary adenoma (237.7) Neurofibromatosis (238) Neoplasm of uncertain behavior of ...
*  Field cancerization
... bile duct, pancreas, small intestine and colon/rectum. The field defect adjacent to a colon cancer consists of the inner ... and MGMT genes in colorectal cancer associated with adenoma-carcinoma sequence". Langenbecks Arch Surg. 396 (7): 1017-26. doi: ... "Bile acids induce ectopic expression of intestinal guanylyl cyclase C through nuclear factor-kappaB and Cdx2 in human ... "Bile acids initiate lineage-addicted gastroesophageal tumorigenesis by suppressing the EGF receptor-AKT axis". Clin Transl Sci ...
*  Orlistat
... obstructed bile duct, impaired liver function, and pancreatic disease The primary side effects of the drug are gastrointestinal ... "Aberrant crypt foci of the colon as precursors of adenoma and cancer" (PDF). N Engl J Med. 339 (18): 1277-84. doi:10.1056/ ...
*  Thyroid
Segments of the duct and cysts that occur high in the neck are lined by stratified squamous epithelium, which is essentially ... The most common neoplasm affecting the thyroid gland is a benign adenoma, usually presenting as a painless mass in the neck. ... perhaps by increasing the rate of secretion of cholesterol in bile. Cardiovascular. The hormones increase the rate and strength ... A persistent thyroglossal duct is the most common clinically significant congenital disorder of the thyroid gland. A persistent ...
*  Medical ultrasound
... bile ducts, kidneys, and spleen are imaged. Sound waves are blocked by gas in the bowel and attenuated in different degree by ... A similar localization procedure with methylene blue, can be done to locate parathyroid adenomas at surgery. Compression ...
*  Neoplasm
Bile acids, at high levels in the colons of humans eating a high fat diet, also cause DNA damage and contribute to colon cancer ... Discrete localized enlargements of normal structures (ureters, blood vessels, intrahepatic or extrahepatic biliary ducts, ... and CDKN2A/p16 in colorectal adenomas". World J. Gastroenterol. 16 (28): 3553-60. doi:10.3748/wjg.v16.i28.3553. PMC 2909555 . ... a secondary bile acid". Arch. Toxicol. 85 (8): 863-71. doi:10.1007/s00204-011-0648-7. PMC 3149672 . PMID 21267546. Katsurano M ...
*  List of OMIM disorder codes
FREM1 Bile acid malabsorption, primary; 613291; SLC10A2 Bile acid synthesis defect, congenital, 2; 235555; AKR1D1 Bile acid ... TCF4 Pituitary adenoma, ACTH-secreting; 219090; AIP Pituitary adenoma, growth hormone-secreting; 102200; AIP Pituitary adenoma ... DCTN1 Persistent Mullerian duct syndrome, type I; 261550; AMH Persistent Mullerian duct syndrome, type II; 261550; AMHR2 ... PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, salivary gland pleomorphic; 181030; PLAG1 Adenomatous polyposis ...
adenoma intrahepatic bile duct 2005:2010[pubdate] *count=100 - BioMedLib™ search engine  adenoma intrahepatic bile duct 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Adenoma, Bile Duct / diagnosis. Adenoma, Bile Duct / metabolism. Bile Ducts, Extrahepatic / metabolism. Bile Ducts, ... Bile duct adenoma with oncocytic features.. *[MeSH-major] Adenoma, Bile Duct / pathology. Bile Duct Neoplasms / pathology. Bile ... A case of intrahepatic bile duct adenoma].. *[MeSH-major] Adenoma, Bile Duct / diagnosis. Bile Duct Neoplasms / diagnosis. Bile ... Bile Duct / complications. Adenoma, Bile Duct / diagnosis. Adult. Aged. Bile Duct Neoplasms / complications. Bile Duct ...
more infohttp://www.bmlsearch.com/?kwr=adenoma+intrahepatic+bile+duct+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Focal nodular hyperplasia of the liver: results of treatment and options in management. Focal nodular hyperplasia of the liver:...  Focal nodular hyperplasia of the liver: results of treatment and options in management. Focal nodular hyperplasia of the liver:...
The bile duct can become obstructed when the bile becomes very thick (inspissated bile plug syndrome, IBPS) or when gall stones ... part 2 Physical activity, obesity, and risk for colon cancer and adenoma in men ... Eight of the infants required surgery to clear the bile duct. Drainage of the biliary tract was required in six cases, and the ... Jaundice can be caused by an obstruction in the duct or tube that carries bile from the gallbladder to the small intestine. ...
more infohttp://www.readabstracts.com/Health/Focal-nodular-hyperplasia-of-the-liver-results-of-treatment-and-options-in-management.html
Bile duct adenoma  Bile duct adenoma
Build: Fri Jul 27 09:23:34 EDT 2018 (commit: a5c8d99). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
more infohttps://pharos.nih.gov/idg/diseases/DOID:5381
Bile duct adenoma - SHM Abstracts  Bile duct adenoma - SHM Abstracts
INTRAHEPATIC BILE DUCT ADENOMA: A DIAGNOSTIC DILEMMA. Case Presentation: A 52-year-old male presented for an evaluation of ... Comments Off on INTRAHEPATIC BILE DUCT ADENOMA: A DIAGNOSTIC DILEMMA ...
more infohttps://www.shmabstracts.com/tag/bile-duct-adenoma/
differential diagnosis of small hcc focusing on pseudolymphoma and bile duct adenoma  differential diagnosis of small hcc focusing on pseudolymphoma and bile duct adenoma
... adenoma, Focal Nodular Hyperplasia (FNH), Bile Duct Adenoma (BDA) and Lymphoproliferative Disorders (LPD) including ... and the size of the small bile ducts of the nodule was almost the same as that of the interlobular bile ducts in the background ... 2016) Bile duct adenoma in patient with chronic hepatitis C - As a benign neoplasm by pathological and imaging studies - Pathol ... We encountered two cases of pseudolymphoma of the liver and two of bile duct adenoma features of which were compared with those ...
more infohttps://gavinpublishers.com/articles/case-report/Annals-of-Case-Reports-ISSN-2574-7754/differential-diagnosis-of-small-hcc-focusing-on-pseudolymphoma-and-bile-duct-adenoma
adenoma intrahepatic bile duct drug 2000:2010[pubdate] *count=100 - BioMedLib™ search engine  adenoma intrahepatic bile duct drug 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-minor] Adenoma, Bile Duct / chemically induced. Adenoma, Bile Duct / pathology. Administration, Oral. Animals. Bile Duct ... Bile Duct / ultrasonography. Bile Duct Diseases / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, ... MeSH-minor] Adenoma, Liver Cell / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic / radiography. Carcinoma ... MeSH-minor] Adenoma, Liver Cell / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Intrahepatic. Carcinoma, ...
more infohttp://www.bmlsearch.com/?kwr=adenoma+intrahepatic+bile+duct+drug+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1
Histopathology Liver disease Flashcards by tish bullman | Brainscape  Histopathology Liver disease Flashcards by tish bullman | Brainscape
Progressive inflammation and fibrosis of large intra and extra hepatic bile ducts ... Along with bile duct adenoma. 6 Liver cell adenoma more common in ...
more infohttps://www.brainscape.com/flashcards/histopathology-liver-disease-2990215/packs/3621475
Bile duct hamartoma | definition of bile duct hamartoma by Medical dictionary  Bile duct hamartoma | definition of bile duct hamartoma by Medical dictionary
... bile duct hamartoma explanation free. What is bile duct hamartoma? Meaning of bile duct hamartoma medical term. What does bile ... Looking for online definition of bile duct hamartoma in the Medical Dictionary? ... Cholangiocarcinoma arising in bile duct adenoma with focal area of bile duct hamartoma. ... bile duct hamartoma. bile duct hamartoma. A benign developmental lesion(s) of the liver located in the periportal tract, which ...
more infohttp://medical-dictionary.thefreedictionary.com/bile+duct+hamartoma
Benign Liver Tumors - Hepatic and Biliary Disorders - Merck Manuals Professional Edition  Benign Liver Tumors - Hepatic and Biliary Disorders - Merck Manuals Professional Edition
Bile duct adenoma Focal nodular hyperplasia Hemangioma Hepatocellular adenoma Am I Correct?. ... Benign bile duct adenomas are rare, inconsequential, and usually detected incidentally. They are sometimes mistaken for ... Hepatocellular adenoma. Hepatocellular adenoma is the most important benign tumor to recognize. It occurs primarily in women of ... Adenomas due to contraceptive use may regress if the contraceptive is stopped. If the adenoma does not regress or if it is ...
more infohttp://www.merckmanuals.com/en-pr/professional/hepatic-and-biliary-disorders/liver-masses-and-granulomas/benign-liver-tumors
MRI Evaluation of masses in the noncirrhotic liver  MRI Evaluation of masses in the noncirrhotic liver
... bile duct adenoma; biliary papillomatosis; Clonorchis sinensis infection; and Thorotrast (thorium dioxide) exposure.38-39 The ... Craig J, Peters R, Edmondson H. Tumors of the liver and intrahepatic bile ducts. In: Hartman H, Sobin L, eds. Atlas of Tumor ... Unlike fibrolamellar HCC, the central scar in FNH is not a true scar, but represents a confluence of blood vessels, bile ducts ... Hepatic adenoma. Although the precise pathogenic mechanism leading to hepatic adenomas is still unknown, the use of estrogen- ...
more infohttp://appliedradiology.com/articles/mri-evaluation-of-masses-in-the-noncirrhotic-liver
Tumor Search Results  Tumor Search Results
Liver - Bile duct adenoma. Liver - Bile duct. None (spontaneous). FVB/NJ inbred 0. 0. Summary ... Liver hepatocellular adenoma. Liver. None (spontaneous). FVB/NHsd inbred 0. 0. Summary ... Liver hepatocellular adenoma. Liver. None (spontaneous). FVB/NTac inbred 0. 17. Summary ...
more infohttp://tumor.informatics.jax.org/mtbwi/tumorSearchResults.do?grid=1&strainFamilyKey=54&organParentKey=26
Tumor Search Results  Tumor Search Results
Liver - Bile duct adenoma. Liver - Bile duct. None (spontaneous). C57BLKS/J inbred 0. 0. Summary ...
more infohttp://tumor.informatics.jax.org/mtbwi/tumorSearchResults.do?grid=1&strainFamilyKey=28&organParentKey=26
MIXED ADENOMA (HAMARTOMA) OF THE LIVER: REPORT OF A CASE* | Annals of Internal Medicine | American College of Physicians  MIXED ADENOMA (HAMARTOMA) OF THE LIVER: REPORT OF A CASE* | Annals of Internal Medicine | American College of Physicians
These are classified as liver cell adenomas or bile duct adenomas. In addition, a third type of tumor occurs. This lesion is ... MIXED ADENOMA (HAMARTOMA) OF THE LIVER: REPORT OF A CASE(MIXED ADENOMA (HAMARTOMA) OF THE LIVER: REPORT OF A CASE*) ROBERT M. ... MIXED ADENOMA (HAMARTOMA) OF THE LIVER: REPORT OF A CASE(MIXED ADENOMA (HAMARTOMA) OF THE LIVER: REPORT OF A CASE*). Ann Intern ... Primary benign liver tumors may arise from either the liver cells or the bile duct epithelium. ...
more infohttp://annals.org/aim/article-abstract/675193/mixed-adenoma-hamartoma-liver-report-case
Case Reports - Reviews sub-cluster 29  Case Reports - Reviews sub-cluster 29
We report here a case of common bile duct papillary adenoma in a 69-year-old female who presented with symptoms of common bile ... Papillary adenomas of the common bile duct are a rare entity with few published case reports and limited knowledge on its ... Metanephric adenoma (MA) of the kidney is an uncommon benign epithelial tumour that can present at any age. The histology of ... We report the case of a 66 year-old man with a villous adenoma and synchronic infiltrating transitional cell carcinoma of the ...
more infohttp://www.biomedsearch.com/cluster/53/Case-Reports-Reviews/sub-29-p2.html
Bile Duct Cystadenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials  Bile Duct Cystadenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
intrahepatic bile duct adenoma 10.3. AFP KRT7 Graphical network of the top 20 diseases related to Bile Duct Cystadenocarcinoma ... MalaCards integrated aliases for Bile Duct Cystadenocarcinoma:. Name: Bile Duct Cystadenocarcinoma 12 15 74 ... MalaCards organs/tissues related to Bile Duct Cystadenocarcinoma:. 42 Liver, Breast, Testis, Lung, Ovary, Pancreas, Thymus ... Articles related to Bile Duct Cystadenocarcinoma:. (show top 50) (show all 69) #. Title. Authors. Year. ...
more infohttps://www.malacards.org/card/bile_duct_cystadenocarcinoma
Liver Cancer and Tumors in Dogs: Free Brochure on Treatment Options  Liver Cancer and Tumors in Dogs: Free Brochure on Treatment Options
Bile duct adenomas. Understanding Canine Anatomy and Liver Tumors The pictures in this section are reprinted with permission by ... The survival rate for dogs with neuroendocrine tumors and bile duct carcinoma after surgery is not good due to the risk of ... If the tumor is a neuroendocrine tumor or bile duct carcinoma, the prognosis is not as good, since there is a greater ... Less common tumors can spread (metastasis) such as bile duct carcinomas and neuroendocrine tumors.. Primary tumors can be found ...
more infohttps://www.dog-health-guide.org/livertumordog.html
Liver Disease | Cirrhosis of the Liver | MaineHealth  Liver Disease | Cirrhosis of the Liver | MaineHealth
Cancer: Including liver cancer, bile duct cancer and liver adenoma. Liver Disease Risk Factors There are many different risks ...
more infohttps://mainehealth.org/services/gastroenterology/liver-disease-cirrhosis
  • Telangiectatic adenoma is a recently recognized variant of HCA formerly classified as a type of focal nodular hyperplasia. (medscape.com)
  • GB like symptoms.US-distal dilation of CBD 7.7mm.MRCP-mild prominence of pancreatic duct.Dense adhesions between GB & abdominal wall. (healthtap.com)
  • This leads to different congenital bile duct disorders, such as Caroli disease and syndrome, autosomal recessive polycystic kidney disease, autosomal dominant polycystic kidney disease, congenital hepatic fibrosis, and bile duct hamartomas (BDHs, also known as von Meyenburg complexes). (thefreedictionary.com)
  • Three variants are known to exist, FAP and attenuated FAP (originally called hereditary flat adenoma syndrome ) are caused by APC gene defects on chromosome 5 while autosomal recessive FAP (or MYH-associated polyposis ) is caused by defects in the MUTYH gene on chromosome 1. (wikipedia.org)
  • Objective:We present the first reported case of sebaceous adenoma of the palate, to our knowledge.Method:Case report and review of the English language literature, with a focus on the pathological spectrum of sebaceous glands.Case report:A woman presented with a growth on the hard palate, which was excised and examined. (biomedsearch.com)
  • Decreases in dosages and the types of hormones contained in OCPs have led to a reduction in adenoma incidence, as reported by another study by Edmonson et al. (medscape.com)
  • [ 7 ] Rooks et al reported that in women who have never used OCPs, the annual incidence of hepatic adenoma is 1 to 1.3 per million but increases to 3.4 per 100,000 in long-term users. (medscape.com)
  • Imaging studies of pseudolymphoma of the liver in a 57-year-old woman who had Sustained Virological Response (SVR) to Interferon (IFN) treatment of Hepatitis C Virus (HCV), and a bile duct adenoma in a 39-year-old man, who had sustained SVR by treatment of HCV with Pegylated (Peg) IFN plus ribavirin were analyzed through imaging modalities and histochemical studies. (gavinpublishers.com)
  • In a two-generation feeding study in rats with lower dose levels, increased incidences of parathyroid adenomas and adrenal phaeochromocytomas were observed in animals of each sex and liver neoplastic nodules in females of the F 1 generation [ref: (inchem.org)