The channels that collect and transport the bile secretion from the BILE CANALICULI, the smallest branch of the BILIARY TRACT in the LIVER, through the bile ductules, the bile ducts out the liver, and to the GALLBLADDER for storage.
A benign epithelial tumor with a glandular organization.
The largest bile duct. It is formed by the junction of the CYSTIC DUCT and the COMMON HEPATIC DUCT.
An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.
Diseases in any part of the ductal system of the BILIARY TRACT from the smallest BILE CANALICULI to the largest COMMON BILE DUCT.
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
Passages external to the liver for the conveyance of bile. These include the COMMON BILE DUCT and the common hepatic duct (HEPATIC DUCT, COMMON).
Tumors or cancer of the BILE DUCTS.
Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.
Diseases of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
A benign tumor of the intrahepatic bile ducts.
Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.
Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHIASIS. Gallstones, derived from the BILE, consist mainly of calcium, cholesterol, or bilirubin.
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)
Fiberoptic endoscopy designed for duodenal observation and cannulation of VATER'S AMPULLA, in order to visualize the pancreatic and biliary duct system by retrograde injection of contrast media. Endoscopic (Vater) papillotomy (SPHINCTEROTOMY, ENDOSCOPIC) may be performed during this procedure.
An imaging test of the BILIARY TRACT in which a contrast dye (RADIOPAQUE MEDIA) is injected into the BILE DUCT and x-ray pictures are taken.
Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct.
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
Impairment of bile flow in the large BILE DUCTS by mechanical obstruction or stricture due to benign or malignant processes.
The duct that is connected to the GALLBLADDER and allows the emptying of bile into the COMMON BILE DUCT.
Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).
The largest lymphatic vessel that passes through the chest and drains into the SUBCLAVIAN VEIN.
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Excision of the gallbladder through an abdominal incision using a laparoscope.
A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.
Surgical removal of the GALLBLADDER.
Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.
A benign epithelial tumor of the LIVER.
Inflammation of the biliary ductal system (BILE DUCTS); intrahepatic, extrahepatic, or both.
Any surgical procedure performed on the biliary tract.
Application of a ligature to tie a vessel or strangulate a part.
Presence or formation of GALLSTONES in the COMMON BILE DUCT.
Incision of Oddi's sphincter or Vater's ampulla performed by inserting a sphincterotome through an endoscope (DUODENOSCOPE) often following retrograde cholangiography (CHOLANGIOPANCREATOGRAPHY, ENDOSCOPIC RETROGRADE). Endoscopic treatment by sphincterotomy is the preferred method of treatment for patients with retained or recurrent bile duct stones post-cholecystectomy, and for poor-surgical-risk patients that have the gallbladder still present.
A storage reservoir for BILE secretion. Gallbladder allows the delivery of bile acids at a high concentration and in a controlled manner, via the CYSTIC DUCT to the DUODENUM, for degradation of dietary lipid.
Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.
Any of the ducts which transport saliva. Salivary ducts include the parotid duct, the major and minor sublingual ducts, and the submandibular duct.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.
Linear TETRAPYRROLES that give a characteristic color to BILE including: BILIRUBIN; BILIVERDIN; and bilicyanin.
Minute intercellular channels that occur between liver cells and carry bile towards interlobar bile ducts. Also called bile capillaries.
Non-invasive diagnostic technique for visualizing the PANCREATIC DUCTS and BILE DUCTS without the use of injected CONTRAST MEDIA or x-ray. MRI scans provide excellent sensitivity for duct dilatation, biliary stricture, and intraductal abnormalities.
Abnormal passage in any organ of the biliary tract or between biliary organs and other organs.
A malignant tumor arising from the epithelium of the BILE DUCTS.
A pair of excretory ducts of the middle kidneys (MESONEPHROI) of an embryo, also called mesonephric ducts. In higher vertebrates, Wolffian ducts persist in the male forming VAS DEFERENS, but atrophy into vestigial structures in the female.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.
The sphincter of the hepatopancreatic ampulla within the duodenal papilla. The COMMON BILE DUCT and main pancreatic duct pass through this sphincter.
Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).
Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.
A pair of ducts near the WOLFFIAN DUCTS in a developing embryo. In the male embryo, they degenerate with the appearance of testicular ANTI-MULLERIAN HORMONE. In the absence of anti-mullerian hormone, mullerian ducts give rise to the female reproductive tract, including the OVIDUCTS; UTERUS; CERVIX; and VAGINA.
A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.
Retrograde bile flow. Reflux of bile can be from the duodenum to the stomach (DUODENOGASTRIC REFLUX); to the esophagus (GASTROESOPHAGEAL REFLUX); or to the PANCREAS.
A congenital anatomic malformation of a bile duct, including cystic dilatation of the extrahepatic bile duct or the large intrahepatic bile duct. Classification is based on the site and type of dilatation. Type I is most common.
FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cirrhosis involves the destruction of small intra-hepatic bile ducts and bile secretion. Secondary biliary cirrhosis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.
Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.
The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.
An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.
Surgical formation of an opening (stoma) into the COMMON BILE DUCT for drainage or for direct communication with a site in the small intestine, primarily the DUODENUM or JEJUNUM.
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.
Tumors or cancer of the gallbladder.
A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A bile pigment that is a degradation product of HEME.
A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.
Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.
The 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholanic acid family of bile acids in man, usually conjugated with glycine or taurine. They act as detergents to solubilize fats for intestinal absorption, are reabsorbed by the small intestine, and are used as cholagogues and choleretics.
A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.
Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic).
Surgical formation of an opening through the ABDOMINAL WALL into the JEJUNUM, usually for enteral hyperalimentation.
A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.
Straight tubes commencing in the radiate part of the kidney cortex where they receive the curved ends of the distal convoluted tubules. In the medulla the collecting tubules of each pyramid converge to join a central tube (duct of Bellini) which opens on the summit of the papilla.
A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)
Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
Pathological processes of the LIVER.
A tubular duct that conveys TEARS from the LACRIMAL GLAND to the nose.
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
Inflammation of the GALLBLADDER; generally caused by impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, or other diseases.
Tumors or cancers of the ADRENAL CORTEX.
Excision of all or part of the liver. (Dorland, 28th ed)
A Y-shaped surgical anastomosis of any part of the digestive system which includes the small intestine as the eventual drainage site.
Paired ducts in the human male through which semen is ejaculated into the urethra.
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
The destruction of a calculus of the kidney, ureter, bladder, or gallbladder by physical forces, including crushing with a lithotriptor through a catheter. Focused percutaneous ultrasound and focused hydraulic shock waves may be used without surgery. Lithotripsy does not include the dissolving of stones by acids or litholysis. Lithotripsy by laser is LITHOTRIPSY, LASER.
The condition of an anatomical structure's being dilated beyond normal dimensions.
A condition characterized by the formation of CALCULI and concretions in the hollow organs or ducts of the body. They occur most often in the gallbladder, kidney, and lower urinary tract.
Tumors or cancer of the DUODENUM.
A tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function. It may cause skin and kidney damage.
A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.
Endoscopic examination, therapy or surgery of the luminal surface of the duodenum.
The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.
Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Surgery of the smooth muscle sphincter of the hepatopancreatic ampulla to relieve blocked biliary or pancreatic ducts.
A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.
Instruments for the visual examination of interior structures of the body. There are rigid endoscopes and flexible fiberoptic endoscopes for various types of viewing in ENDOSCOPY.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.
The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.
Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.
A malignant epithelial tumor with a glandular organization.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
A bile salt formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. It is used as a cholagogue and choleretic, also industrially as a fat emulsifier.
A bile salt formed in the liver by conjugation of chenodeoxycholate with taurine, usually as the sodium salt. It acts as detergent to solubilize fats in the small intestine and is itself absorbed. It is used as a cholagogue and choleretic.
Diseases of the GALLBLADDER. They generally involve the impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, neoplasms, or other diseases.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Endoscopic examination, therapy or surgery of the digestive tract.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
Recycling through liver by excretion in bile, reabsorption from intestines (INTESTINAL REABSORPTION) into portal circulation, passage back into liver, and re-excretion in bile.
The condition of an anatomical structure's being constricted beyond normal dimensions.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
Pathological processes of the PANCREAS.
Adenocarcinoma of the common hepatic duct bifurcation. These tumors are generally small, sharply localized, and seldom metastasizing. G. Klatskin's original review of 13 cases was published in 1965. Once thought to be relatively uncommon, tumors of the bifurcation of the bile duct now appear to comprise more than one-half of all bile duct cancers. (From Holland et al., Cancer Medicine, 3d ed, p1457)
Any fluid-filled closed cavity or sac that is lined by an EPITHELIUM. Cysts can be of normal, abnormal, non-neoplastic, or neoplastic tissues.
The transference of a part of or an entire liver from one human or animal to another.
Tumors or cancer of the LIVER.
Tumors or cancer of the SALIVARY GLANDS.
An abnormal concretion occurring mostly in the urinary and biliary tracts, usually composed of mineral salts. Also called stones.
Ultrasonography of internal organs using an ultrasound transducer sometimes mounted on a fiberoptic endoscope. In endosonography the transducer converts electronic signals into acoustic pulses or continuous waves and acts also as a receiver to detect reflected pulses from within the organ. An audiovisual-electronic interface converts the detected or processed echo signals, which pass through the electronics of the instrument, into a form that the technologist can evaluate. The procedure should not be confused with ENDOSCOPY which employs a special instrument called an endoscope. The "endo-" of endosonography refers to the examination of tissue within hollow organs, with reference to the usual ultrasonography procedure which is performed externally or transcutaneously.
A subclass of ORGANIC ANION TRANSPORTERS whose transport of organic anions is driven either directly or indirectly by a gradient of sodium ions.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.
A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
Infection of the biliary passages with CLONORCHIS SINENSIS, also called Opisthorchis sinensis. It may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. (From Dorland, 27th ed)
Fragmentation of CALCULI, notably urinary or biliary, by LASER.
Congenital cystic dilatation of the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC). It consists of 2 types: simple Caroli disease is characterized by bile duct dilatation (ectasia) alone; and complex Caroli disease is characterized by bile duct dilatation with extensive hepatic fibrosis and portal hypertension (HYPERTENSION, PORTAL). Benign renal tubular ectasia is associated with both types of Caroli disease.
Tumors or cancer of the COLON.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
The narrow tube connecting the YOLK SAC with the midgut of the EMBRYO; persistence of all or part of it in post-fetal life produces abnormalities, of which the commonest is MECKEL DIVERTICULUM.
A benign neoplasm of muscle (usually smooth muscle) with glandular elements. It occurs most frequently in the uterus and uterine ligaments. (Stedman, 25th ed)
The glycine conjugate of CHOLIC ACID. It acts as a detergent to solubilize fats for absorption and is itself absorbed.
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
Establishment of an opening into the gallbladder either for drainage or surgical communication with another part of the digestive tract, usually the duodenum or jejunum.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Elements of limited time intervals, contributing to particular results or situations.
Interference with the secretion of tears by the lacrimal glands. Obstruction of the LACRIMAL SAC or NASOLACRIMAL DUCT causing acute or chronic inflammation of the lacrimal sac (DACRYOCYSTITIS). It is caused also in infants by failure of the nasolacrimal duct to open into the inferior meatus and occurs about the third week of life. In adults occlusion may occur spontaneously or after injury or nasal disease. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p250)
Tumors or cancer of the INTESTINES.
Radiography of the gallbladder after ingestion of a contrast medium.
The part of the membranous labyrinth that traverses the bony vestibular aqueduct and emerges through the bone of posterior cranial fossa (CRANIAL FOSSA, POSTERIOR) where it expands into a blind pouch called the endolymphatic sac.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).
A radiopharmaceutical used extensively in cholescintigraphy for the evaluation of hepatobiliary diseases. (From Int Jrnl Rad Appl Inst 1992;43(9):1061-4)
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
Tumors or cancer of the PAROTID GLAND.
Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.
Organic or functional motility disorder involving the SPHINCTER OF ODDI and associated with biliary COLIC. Pathological changes are most often seen in the COMMON BILE DUCT sphincter, and less commonly the PANCREATIC DUCT sphincter.
Acute inflammation of the GALLBLADDER wall. It is characterized by the presence of ABDOMINAL PAIN; FEVER; and LEUKOCYTOSIS. Gallstone obstruction of the CYSTIC DUCT is present in approximately 90% of the cases.
The act of dilating.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A mass of histologically normal tissue present in an abnormal location.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Tumors or cancer of the ADRENAL GLANDS.
A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.
A system of vessels in which blood, after passing through one capillary bed, is conveyed through a second set of capillaries before it returns to the systemic circulation. It pertains especially to the hepatic portal system.
An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).
Presence or formation of GALLSTONES in the GALLBLADDER.
Liver disease caused by infections with parasitic flukes of the genus FASCIOLA, such as FASCIOLA HEPATICA.
A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A genus of trematode liver flukes of the family Opisthorchidae. It consists of the following species: O. felineus, O. noverca (Amphimerus noverca), and O. viverrini. The intermediate hosts are snails, fish, and AMPHIBIANS.
Infection with flukes of the genus Opisthorchis.
A species of trematode flukes of the family Opisthorchidae. Many authorities consider this genus belonging to Opisthorchis. It is common in China and other Asiatic countries. Snails and fish are the intermediate hosts.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.
A strongly basic anion exchange resin whose main constituent is polystyrene trimethylbenzylammonium Cl(-) anion.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
A spiral tube that is firmly suspended in the bony shell-shaped part of the cochlea. This ENDOLYMPH-filled cochlear duct begins at the vestibule and makes 2.5 turns around a core of spongy bone (the modiolus) thus dividing the PERILYMPH-filled spiral canal into two channels, the SCALA VESTIBULI and the SCALA TYMPANI.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
A focal malformation resembling a neoplasm, composed of an overgrowth of mature cells and tissues that normally occur in the affected area.
The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.

Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine. (1/118)

The modifying effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a mutagenic by-product in chlorinated water, on the development of glandular stomach cancers were investigated in Wistar rats. A total of 120 males, 6 weeks of age, were divided into six groups. After initiation with 100 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) solution and 5% NaCl diet for 8 weeks, 30 rats each in groups 1-3 were given MX in the drinking water at concentrations of 30, 10, or 0 ppm for the following 57 weeks. Ten animals each in groups 4-6 were administered the MX without prior carcinogen exposure. There were no statistical significant differences in final body weights between the groups. The incidences and multiplicities of adenocarcinomas in the glandular stomachs were significantly higher (P < 0.05) in the initiated 30 ppm MX group than those in the MNNG/NaCl group. The incidences of atypical hyperplasias in the glandular stomachs were also significantly increased (P < 0.05 or 0.01) by the MX treatments. With their multiplicity, the effects were clearly dose dependent. Interestingly, the 30 ppm MX alone itself induced atypical hyperplasias in the pylorus, although the incidences and severity were low. Moreover, MX showed a tendency to enhance the development of intrahepatic cholangiocellular tumors and thyroid follicular cell tumors in the MNNG-treated animals. The results of the present study thus indicate that MX exerts promoting effects when given during the postinitiation phase of two-stage glandular stomach carcinogenesis in rats.  (+info)

Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine. (2/118)

Human liver cancers have been associated mainly with chronic inflammations such as viral hepatitis B or C. This suggests that prolonged cell damage by chronic inflammation is critical in cancer development. Overproduction of nitric oxide (NO.) and its derivative (NOx, peroxynitrite) has been implicated as a cause of tissue damage by inflammation, thus contributing to tumor promotion. We have demonstrated the expression of the inducible isoform of nitric oxide synthase (iNOS) and 3-nitrotyrosine, a marker of peroxynitrite formation, by immunohistochemistry in preneoplastic and neoplastic rat liver tissues induced by continuous infusion of N-nitrosodiethylamine with mini-pumps. The preneoplastic lesions were characterized by proliferation of phenotypically altered hepatic foci (PAHF), dysplastic hepatocytes and oval cells. Histologically, the tumors were hepatocellular carcinomas (HCCs) of trabecular, (pseudo)glandular and solid types with or without cholangiocellular involvement. iNOS was located mainly in oval cells, capillary endothelial and muscular cells, epithelia of cholangiomas and glandular HCCs. 3-Nitrotyrosine was observed in the cytoplasms of PAHF and dysplastic hepatocytes in preneoplasias and in the cytoplasms of some living or apoptotic HCC cells, connective tissues, proteinaceous fluids, sinusoidal endothelia of tumorous hepatocytes and cholangiomas in tumors. From these observations, we suggest that: (i) chronic tissue damage by chemical carcinogens may act to induce iNOS and peroxynitrite formation; (ii) oval cells play a key role in development and/or growth of tumor tissues by producing NO. via iNOS, which may also cause tissue damage by peroxynitrite; (iii) iNOS can be considered as a phenotypic marker in cells of oval cell lineage and neovascularized capillaries in tumor tissues.  (+info)

Primary liver carcinoma in genetic hemochromatosis reveals a broad histologic spectrum. (3/118)

Hepatocellular carcinoma (HCC) is a well-known complication of genetic hemochromatosis (GH). However, the frequency of primary liver carcinoma (PLC) with biliary differentiation, such as cholangiocarcinoma (CC) and combined hepatocholangiocarcinoma (CHCC), in GH remains unclear We analyzed the histologic type of 20 PLCs occurring in the background of GH; all patients were homozygotic for the C282Y mutation. Ten were depleted of iron by successive phlebotomies, while the remaining 10 were untreated. Histologically, 13 cases were classified as HCC, 3 as CC, and 4 as CHCC. Immunohistochemical detection of Hep Par 1, cytokeratin 19 (CK19), and MUC1 supported this classification; PLC with biliary differentiation was immunoreactive for MUC1 in 86% (6/7) of cases and for CK19 in 100% (7/7) of cases. The nontumoral liver exhibited no cirrhosis or extensive fibrosis in 6 cases. Von Meyenburg complexes were present in 11 cases and intraparenchymal bile duct adenomas in 3. These data suggest that PLCs in patients with GH present a wide histologic spectrum, with tumors showing frequent biliary differentiation; may arise on a nonfibrotic or a cirrhotic liver; and often are associated with Von Meyenburg complexes and to a lesser extent with bile duct adenomas.  (+info)

Management strategies in resection for hilar cholangiocarcinoma. (4/118)

Between 1960 and 1990, resection was performed in 23 of 122 patients who underwent surgical treatment for hilar cholangiocarcinoma. Local excision of the lesion alone was performed in 10 cases (43%). Hepatic resection for tumor extending to the secondary bile ducts or hepatic parenchyma was performed in 13 cases (57%): extended right hepatectomy (3), right hepatectomy (1), extended left hepatectomy (6), left hepatectomy (2), and left lobectectomy (1). In three other cases, resection by total hepatectomy and liver transplantation was performed, but these were not included in the analysis of results for resection. Significant operative complications occurred in only two cases (8.7%), and the operative mortality rate was zero. In four cases, complete excision of the tumor could not be achieved macroscopically (macroscopic curative resection rate 19/122; 15.6%). In nine cases, the margins of the resected specimens were free from tumor on histologic examination (microscopic curative resection rate, 9/122; 7.4%). In 10 cases, the resection margins were found to contain tumor on histologic examination. The overall survival rate was 87% at 1 year, 63% at 2 years, and 25% at 3 years (median survival, 24 months). The survival and freedom from recurrence rates for patients with free resection margins was superior to that for patients with involved resection margins or residual macroscopic disease. A potentially curative resection, with histologically negative margins and no recurrence to date, was achieved in seven patients using the following procedures: local excision for two type I lesions; left hepatectomy plus excision of segment 1 for two type IIIb lesions and one type IV lesion; right hepatectomy and right hepatectomy plus excision of segment 1 for two type IIIa lesions. These results indicate that improved survival in hilar cholangiocarcinoma can be achieved by resection, with minimal morbidity and zero mortality rates, if histologically free resection margins are obtained. To achieve this, we recommend the following procedures for each type of lesion, based on our experience and on anatomic considerations: local excision for type I; local excision plus resection of segment 1 for type II; local excision, resection of segment 1, and right or left hepatectomy for types IIIa and b; hepatectomy plus liver transplantation for type IV.  (+info)

Low frequency of p53 gene mutation in tumors induced by aflatoxin B1 in nonhuman primates. (5/118)

Aflatoxin B1 has been suggested as a causative agent for a G to T mutation at codon 249 in the p53 gene in human hepatocellular carcinomas from southern Africa and Qidong in China. To test this hypothesis, nine tumors induced by aflatoxin B1 in nonhuman primates were analyzed for mutations in the p53 gene. These included four hepatocellular carcinomas, two cholangiocarcinomas, a spindle cell carcinoma of the bile duct, a hemangioendothelial sarcoma of the liver, and an osteogenic sarcoma of the tibia. None of the tumors showed changes at the third position of codon 249 by cleavage analysis of the HaeIII enzyme site at codon 249. A point mutation was identified in one hepatocellular carcinoma at the second position of codon 175 (G to T transversion) by sequencing analysis of the four conserved domains (II to V) in the p53 gene. These data suggest that mutations in the p53 gene are not necessary in aflatoxin B1 induced hepatocarcinogenesis in nonhuman primates. The occurrence of mutation in codon 249 of the p53 gene in selective samples of human hepatocellular cancers may indicate involvement of environmental carcinogens other than aflatoxin B1 or that hepatitis B virus-related hepatitis is a prerequisite for aflatoxin B1 induction of G to T transversion in codon 249.  (+info)

Evaluation of liver tumors using fluorine-18-fluorodeoxyglucose PET: characterization of tumor and assessment of effect of treatment. (6/118)

To evaluate glucose metabolism in patients with tumors involving the liver, 35 patients with liver lesions had PET using 18F-2-fluoro-2-deoxy-D-glucose (FDG). FDG (148 MBq) was injected and radioactivity of the tumor was scanned dynamically by PET. The rate constants (k1, k2, k3, k4) of FDG in a metabolic model were calculated. The results were compared to hexokinase activity in the excised tumor specimens. k3 was found to reflect tumor hexokinase activity. When k3 was used as an index (cut-off value: 0.025), it was possible to distinguish benign and malignant tumors. k4 was significantly higher in hepatocellular carcinoma. By using k3 and k4 as indices, one could assess the degree of differentiation of hepatocellular carcinoma. After treatment, k3 decreased according to the effectiveness of therapy and thus may be a useful index for quantitatively assessing tumor viability.  (+info)

Analysis of failure after curative irradiation of extrahepatic bile duct carcinoma. (7/118)

Thirty-four patients with subtotally resected or unresectable carcinoma of the extrahepatic bile ducts received radiation therapy; a minimum of 45 Gy (external beam) to the tumor and regional lymph nodes +/- 5-fluorouracil (5-FU). Seventeen patients received an external beam boost of 5 to 15 Gy to the tumor, and a specialized boost was used in the remaining 17 patients (iridium-192 transcatheter seeds in 10 and intraoperative radiation therapy [IORT] with electrons in seven). The median time to death in all 34 patients was 12 months (range, 4 to 98-months). The only patients who survived longer than 18 months were those either with gross total or subtotal resection before external irradiation (2 of 6) or who received specialized boosts (192Ir, 3 of 10; IORT, 3 of 7). Local failure was documented in 9 of 17 patients who received external beam irradiation alone +/- 5-FU, 3 of 10 patients who received an 192Ir boost, and 2 of 6 patients who received an IORT boost with curative intent.  (+info)

Clinical evaluation of a new serum tumour marker CA 242 in pancreatic carcinoma. (8/118)

The aim of this study was to evaluate the new monoclonal tumour marker CA 242 in the diagnosis of pancreatic carcinoma and to compare it with the established markers CA 50 and CEA. Serum concentrations were determined in 113 patients with jaundice, in 20 patients with laboratory values suggesting cholestasis, and in 60 patients with a suspicion to have chronic pancreatitis. Twenty-four of these 193 patients had pancreatic carcinoma and two patients had carcinoma of papilla of Vater. The sensitivities of CA 242, CA 50 and CEA were 80.7%, 96.1%, and 92.3%, respectively. The specificities were 79.0%, 58.0%, and 59.2%. The sensitivities of combinations of CA 50 and CEA with CA 242 did not exceed the sensitivity of CA 50 alone. The specificity of CA 242 was improved by combining it with CEA (92.2%). The serum marker CA 242 seems to be less sensitive than CEA and CA 50 in the detection of pancreatic carcinoma, but it may prove useful because of its high specificity.  (+info)

The cell phenotype of so-called bile duct adenoma (BDA) was investigated immunohistochemically using monoclonal antibodies to two recently identified
article{8510062, abstract = {Unlike its family member p53, TP63 is rarely mutated in human cancer. However, Delta Np63 alpha protein levels are often elevated in tumors of epithelial origin, such as squamous cell carcinoma and cholangiocarcinoma. To study the oncogenic properties of Delta Np63 alpha in vivo, we generated transgenic mice overexpressing Delta Np63 alpha from the Rosa26 locus promoter controlled by keratin 5-Cre. We found that these mice spontaneously develop epidermal cysts and ectopic Delta Np63 alpha expression in the bile duct epithelium that leads to dilatation of the intrahepatic biliary ducts, to hepatic cyst formation and bile duct adenoma. Moreover, when subjected to models of 7,12-dimethylbenz[a]anthracene-based carcinogenesis, tumor initiation was increased in Delta Np63 alpha transgenic mice in a gene dosage-dependent manner although Delta Np63 alpha overexpression did not alter the sensitivity to 7,12-dimethylbenz[a] anthracene-induced cytotoxicity in vivo. However, ...
Primary benign tumors of the liver, other than angiomas, are rare. Hoffman1 reviewed the literature in 1942 and was able to find only 58 cases reported. He added one case of his own. No attempt was made to classify these lesions.. Primary benign liver tumors may arise from either the liver cells or the bile duct epithelium. These are classified as liver cell adenomas or bile duct adenomas. In addition, a third type of tumor occurs. This lesion is composed of both liver cells and bile ducts. Such lesions have been classified by Warvi2 as. ...
TY - JOUR. T1 - Benign hepatocellular tumors. AU - Guzman, Ignacio J.. AU - Gold, Jay H.. AU - Rosai, Juan. AU - Schneider, Philip D.. AU - Varco, Richard L.. AU - Buchwald, Henry. PY - 1977/10. Y1 - 1977/10. N2 - This series summarizes all cases diagnosed as benign hepatocellular tumors occurring at the University of Minnesota Hospitals from 1950 to 1976. Excluding hemangiomas, 40 tumors were reviewed and reclassified. Eighteen were diagnosed as focal nodular hyperplasia (FNH), 10 as hepatocellular adenomas (HCS), 11 as bile duct adenomas (BDA), and one as a mesenchymal hamartoma. FNH: The female: male ratio was 8:1, and the mean age was 43 years ±18 (SD). Two patients were symptomatic; of these, one presented with portal hypertension. Treatment consisted of local resection in 12, left hepatectomy in one, and right hepatectomy in two. Eight patients had a history of oral contraceptive or other steroid intake. The tumors occurring after 1964 were larger (p , 0. 05). HCA: The female: male ratio ...
Yun‐Yong Park, Sang‐Bae Kim, Hee Dong Han, Bo Hwa Sohn, Ji Hoon Kim, Jiyong Liang, Yiling Lu, Cristian Rodriguez‐Aguayo, Gabriel Lopez‐Berestein, Gordon B. Mills, Anil K. Sood, Ju‐Seog ...
Jae‐Kyung Won, Su Jong Yu, Chae Young Hwang, Sung‐Hwan Cho, Sang‐Min Park, Kwangsoo Kim, Won‐Mook Choi, Hyeki Cho, Eun Ju Cho, Jeong‐Hoon Lee, Kyung Bun Lee, Yoon Jun Kim, Kyung‐Suk Suh, Ja‐June Jang, Chung Yong Kim, Jung‐Hwan Yoon, Kwang‐Hyun ...
There is no known effective treatment for cats and dogs with nodular and diffuse liver tumors as liver tumors are generally considered resistant to chemotherapy and radiation therapy. However, three-dimensional conformal radiation therapy has been reported with objective responses in five of six dogs and minimal acute radiation effects; and the use of adjuvant gemcitabine in dogs with incompletely excised massive HCC, nodular HCC, and diffuse HCC has been reported in 18 dogs with good results.. Palliative treatment options, especially for nodular and diffuse hepatic tumors, include, microwave ablation, embolization, and chemoembolization, but these modalities are not widely available.. PROGNOSIS. The prognosis following surgical resection of massive HCC in dogs and bile duct adenomas in cats is very good. The majority of cats and dogs are cured. In one study of 42 dogs with massive HCC treated with liver lobectomy, two dogs (5%) died intraoperatively secondary to blood loss as a result of ...
লিভার ক্যান্সার(ইংরেজি: Liver cancer) এর অপর নাম হেপাটিক ক্যান্সার (Hepatic cancer) ও প্রাইমারি হেপাটিক ক্যান্সার (primary hepatic cancer), একে বাংলায় যকৃতের ক্যান্সার বলে। যকৃৎ ক্যান্সারের উৎপত্তি যকৃতেই হয়।[১] অন্য অঙ্গ থেকে ক্যান্সার কোষ লিভারে ছড়ালে তাকে লিভার মেটাস্টাসিস বলে।[২] লিভার ক্যান্সারে বক্ষপিঞ্জরের নিচে ডানপাশে দলা বা ব্যথা অনুভূত হয়।অন্যান্য লক্ষণের মধ্যে রয়েছে জন্ডিস, ওজন কমে যাওয়া, ...
These findings are partly in agreement with the current literature. In particular, incidence of hepatic cancer (11), breast cancer (13), and pancreatic cancer (12) has been reported to be higher in patients with diabetes, although the causal role of diabetes in the pathogenesis of the latter cancer has been recently questioned (26).. There is no straightforward explanation for the excess mortality from hepatic cancer in diabetic patients, but several hypotheses can be suggested. First, mortality from cirrhosis is nearly three times higher in patients with type 2 diabetes than in the general population (19). Hepatitis infections could have contributed to the increased mortality from both cirrhosis and hepatic cancer, as a high prevalence of the hepatitis C virus has been reported in diabetic patients (27). Also, alcohol consumption could contribute to the excess mortality from hepatic cancer: in the Paris Prospective Study (28), risk of death from alcohol-related diseases was high in men with ...
The wood-chuck model has been less used to study molecular biology issues, but has been employed extensively in the development of antiviral therapies and in characterization of the link between chronic infection and liver cancer. Christian Chiricuţă este director medical şi şef al Comisiei oncologice alcătuite din experţi radioterapeuţi, fizicieni, oncologi, radiologi, chirurgi cu o pregătire excepţională în ţară şi în străinătate, membri atât ai Societăţii Române de Radioterapie şi Oncologie Medicală, cât şi a celei europene şi americane.
Siragen Pharmaceuticals, a spin-off from NeuroGeneration, is developing small-molecule kinase inhibitors for the treatment of prostate and hepatic cancers.
TY - JOUR. T1 - Histopathological characteristics of hypervascular cholangiocellular carcinoma as an early stage of cholangiocellular carcinoma. AU - Sato, Yuya. AU - Ojima, Hidenori. AU - Onaya, Hiroaki. AU - Mori, Taisuke. AU - Hiraoka, Nobuyoshi. AU - Kishi, Yoji. AU - Nara, Satoshi. AU - Esaki, Minoru. AU - Shimada, Kazuaki. AU - Kosuge, Tomoo. AU - Sugihara, Kenich. AU - Kanai, Yae. PY - 2014/10/1. Y1 - 2014/10/1. N2 - Aim: Prognosis of hypervascular cholangiocellular carcinoma (h-CCC) is reportedly better than that of ordinary hypovascular CCC (o-CCC). The aim of this study is to clarify the histopathological characteristics of h-CCC. Methods: On the basis of the findings in the arterial phase of contrast-enhanced computed tomography, 16 cases of mass-forming-type CCC were divided into two groups (h-CCC, n=8; o-CCC, n=8). Areas of high (Area H-a) and low (Area H-b) attenuation in h-CCC cases and areas of low attenuation in o-CCC cases (Area O) were delineated. These areas were then ...
Tumor staging of extrahepatic bile duct (EBD) carcinoma is problematic for a number of reasons, including definitional problems with the current T classification of the American Joint Committee on Cancer staging system and the common occurrence of severe desmoplastic stromal reaction around the adva
Kinetics, histological and biochemical characteristics of transplantable cholangiocellular RS-1 carcinoma were studied after intrahepatic and subcutaneous
The Hippo pathway effector Yes-associated protein (YAP) is localized to the nucleus and transcriptionally active in a number of tumor types, including a majority of human cholangiocarcinomas. YAP activity has been linked to chemotherapy resistance and has been shown to rescue KRAS and BRAF inhibition in RAS/RAF-driven cancers; however, the underlying mechanisms of YAP-mediated chemoresistance have yet to be elucidated. Herein, we report that the tyrosine phosphatase SHP2 directly regulates the activity of YAP by dephosphorylating pYAPY357 even in the setting of RAS/RAF mutations, and that diminished SHP2 phosphatase activity is associated with chemoresistance in cholangiocarcinomas. A screen for YAP-interacting tyrosine phosphatases identified SHP2, and characterization of cholangiocarcinomas cell lines demonstrated an inverse relationship between SHP2 levels and pYAPY357. Human sequencing data demonstrated lower SHP2 levels in cholangiocarcinomas tumors as compared with normal liver. Cell lines ...
Biliary cystadenomas are uncommon benign cystic neoplasms of the liver. Epidemiology Biliary cystadenomas occur predominantly in middle-aged patients and are more common in women 1. Clinical presentation The clinical presentation of biliary c...
Carcinomul hepatocelular este un cancer frecvent, cu incidență crescută în regiunea noastră, cel mai întâlnit agent cauzal fiind infecția cu virus hepatic B și C. Mean age was Cirrhosis was present in 94 patients and absent in Among patients with hepatic cirrhosis, the higher percentage was class Child-Pugh B: 39 In table 2, there are shown the clinical features at the time of diagnosis of hepatocellular carcinoma with or without type II diabetes. The close monitoring of the patients in this research program brings real benefit for the prevention of liver cancer and diagnosing it early, having a much hepatic cancer pathology prognosis on the quality of life.
My mother died of Cholangiocarcinoma. This is a very uncommon cancer of the bile duct. I have since that day, started this site. Not until today did I look up Cholangiocarcinoma specifically. What I just found astounds me... Was Mom taking a trial drug? A drug that wasnt even approved by the FDA? She…
The oncogenotype of a tumor can promote a specific mechanism of chemoresistance that can contribute to the survival of hepatic CSCs. Under circumstances that promote differentiation of CSCs into more mature tumor cells, the chemoresistance can be quickly lost. Elucidation of the mechanisms that gove …
Liver transplantation is a treatment option for combined hepatocellular and cholangiocellular carcinoma (cHCC-CC) but its prognostic significance remains unclear. The present study aimed to evaluate the therapeutic effects of liver transplantation on cHCC-CC and analyze the clinicopathological factors affecting prognosis. Retrospective analysis of the clinicopathological data of a case series of 21 patients with cHCC-CC who underwent orthotopic liver transplantation from April 2000 to April 2011 was performed. Cumulative survival rate and tumor-free survival rate were calculated using the Kaplan-Meier method followed by the log-rank test. The operative survival rate of the 21 patients was 100%; the 30 day mortality was 4.8% (1/21) and 90-day mortality was 9.5% (2/21); 1-, 2-, 3-, and 5-year overall cumulative survival rates were 64%, 47%, 39%, and 39%, respectively; and the corresponding cumulative tumor-free survival rates were 64%, 37%, 30%, and 30%, respectively. Cumulative tumor diameter, lymph node
Biliary cystadenomas are benign but potentially malignant cystic neoplasms, which classically contain mesenchymal stroma similar to ovarian tissue. We report a case of an extra-hepatic biliary cystadenoma with mesenchymal stroma along with a discussi
Cholangiocarcinomas (CC) frequently demonstrate lymphatic spread. We investigated lymph node (LN) counts after resection of extrahepatic CC and survival based on the SEER 1973-2004 database. Out of 20
Cholangiocellular Carcinoma in Dogs Bile duct carcinoma is a malignant cancer that typically arises from the the epithelia, the cellular lining of the hepatic (
Cholangiocarcinomas are a heterogeneous group of malignancies arising from a number of cells of origin along the biliary tree. Although most cases in Western countries are sporadic, large population-based studies have identified a number of risk factors. This review summarises the evidence behind reported risk factors and current understanding of the molecular pathogenesis of cholangiocarcinoma, with a focus on inflammation and cholestasis as the driving forces in cholangiocarcinoma development. Cholestatic liver diseases (e.g. primary sclerosing cholangitis and fibropolycystic liver diseases), liver cirrhosis, and biliary stone disease all increase the risk of cholangiocarcinoma. Certain bacterial, viral or parasitic infections such as hepatitis B and C and liver flukes also increase cholangiocarcinoma risk. Other risk factors include inflammatory disorders (such as inflammatory bowel disease and chronic pancreatitis), toxins (e.g. alcohol and tobacco), metabolic conditions (diabetes, obesity and non
Cholangiocarcinomas (bile duct cancers) arise from the epithelial cells of the bile ducts. Although they are rare in the United States, these cancers are highly lethal because most are locally advanced at presentation. (See.)The clinical manifestatio
Find the best cholangiocarcinoma doctors in Kolkata. Get guidance from medical experts to select cholangiocarcinoma specialist in Kolkata from trusted hospitals -
Lindsay Y King, Claudia Canasto-Chibuque, Kara B Johnson, Shun Yip, Xintong Chen, Kensuke Kojima, Manjeet Deshmukh, Anu Venkatesh, Poh Seng Tan, Xiaochen Sun, Augusto Villanueva, Angelo Sangiovanni, Venugopalan Nair, Milind Mahajan, Masahiro Kobayashi, Hiromitsu Kumada, Massimo Iavarone, Massimo Colombo, Maria Isabel Fiel, Scott L Friedman, Josep M Llovet, Raymond T Chung, Yujin Hoshida ...
Did you know what is liver cancer is? Liver cancer is also known as hepatic cancer. It is a condition which happens when normal cells in the liver
Several significant cholangiocarcinoma risk factors identified ...
Bile duct cancer information with its causes along with various treatments available. A parasitic infection called the liver fluke is known to be responsible for causing the bile duct cancer. Detailed description of bile duct cancer symptoms also given.
Find the best bile duct cancer doctors in Bangalore. Get guidance from medical experts to select bile duct cancer specialist in Bangalore from trusted hospitals -
What is Bile Duct Cancer (Cholangiocarcinoma)? Get the facts about Bile Duct Cancer (Cholangiocarcinoma) symptoms, testing, treatment and care options from trusted sources.
[504 Pages Report] Check for Discount on Bile Duct Cancer (Cholangiocarcinoma) - Pipeline Review, H1 2016 report by Global Markets Direct. Global Markets Directs, Bile Duct Cancer (Cholangiocarcinoma) - Pipeline Review,...
Cancer of the bile duct (also called cholangiocarcinoma) is extremely rare. The true incidence of bile duct cancer is unknown, however, because establishing an accurate diagnosis is difficult. Traditionally, bile duct tumors located within the liver have been classified with hepatocellular carcinoma as primary liver...
There are several bile duct cancer treatment and preventive procedures to administer to patients of bile duct cancer. Treatments would vary depending on th
For cases of inoperable bile duct carcinoma, we perform intraluminal irradiation using an 192iridium wire following endoprostheses implantation. However, the effectiveness of this procedure is uncertain, and may lead to decreased patient quality of life in some cases. Therefore, we obtained samples of bile duct carcinoma either by percutaneous transhepatic cholangioscope (PTCS) or by surgery, and studied whether expression levels of Ki-67 and p53 in these tissues could predict the effectiveness of radiotherapy (RT). Immunohistochemistry was used to determine the expression of p53 and Ki-67 in 40 resected and 18 biopsy specimens. All biopsy specimens were stage IVA according to UICC classification. Labeling indices were calculated as percentage of positively stained tumor cell nuclei of total tumor cells counted. Samples were divided into two groups according to labeling index (LI). In the resected specimens, Ki-67 LI was significantly higher in cases positive for lymphatic invasion than in ...
Cholangiocarcinoma, also known as bile duct cancer, is often treated the same way as hepatocellular carcinoma, the most common form of primary liver cancer that develops in the main type of liver cell.
The original observations of this study relate to inflammation, NO production, DNA damage, and inhibition of DNA repair as related mechanisms for the development and/or progression of cholangiocarcinoma. Our results directly demonstrate the following: (a) human cholangiocarcinomas express the iNOS protein; (b) proinflammatory cytokines stimulate iNOS message and protein expression and the production of NO in cholangiocarcinoma cell lines; (c) the magnitude of NO produced is sufficient to cause single-stranded, double-stranded, and oxidative DNA lesions in the malignant cell lines; and (d) stimulated NO generation is associated with impaired global DNA repair activity in the cholangiocarcinoma cell lines. These data suggest that NO generated in response to inflammation may initiate malignant transformation of biliary epithelia and/or promote progression of established cholangiocarcinoma. Each of these observations is discussed in greater detail below.. iNOS expression with NO generation has been ...
Learn more about Bile Duct Cancer (Cholangiocarcinoma) Treatment (PDQ®) (Patients) from the National Cancer Institute at Siteman Cancer Center.
Bile duct cancer may be found inside the liver (intrahepatic) or outside the liver (extrahepatic). Learn about risk factors, symptoms, diagnosis and treatment.
Hi,. My mom was just diagnosed with Bile Duct Cancer.. I am in departed need of anyone who has dealt with this type of cancer, or any ones family members who had this. I also would love to hear from people who has beat this type of cancer... this has been a world-wind we never ever expected this to happen; especially in November we was told NO-Cancer!! My mom is my life; we are best friends she lives not even a mile from me. I am so hurt, mad & even angry. I have never ever felt so alone in my LIFE... I will be by my mothers side every-step of the way... I want any suggestions on how to cope with all feelings I am felling. Please help!!!! ...
Chemotherapy (chemo) is a treatment of cancer-killing drugs used to kill bile duct cancer cells. Learn more about chemotherapy here.
Bile duct cancer diagnosis (costs for program #33463) ✔ Sana Hospital Duisburg ✔ Department of Internal Medicine II (Gastroenterology and Hepatology) ✔
Very Rare and Interesting Case of Acute Appendicitis due to Hepatic cancer perfusion vermicularis night Vermicularis hpv likely get cervical cancer Cancerul de piele pe fata respiratory papillomatosis, cancer pulmonar historia natural which type enterobius vermicularis night human papillomavirus hpv is prevented by the vaccines gardasil and cervarix. CT perfusion as an imaging biomarker in monitoring response to neoadjuvant bevacizumab and radiation in soft-tissue sarcomas: comparison with tumor morphology, circulating and tumor biomarkers, and gene expression. Utilizam datele tale in scopul corespondentei si pentru comunicari comerciale.
besides traditional surgery, chemotherapy and radiotherapy for bile duct cancer treatment, there are still integrated combination of TCM and western medicines as well as interventional therapy.
You cant change the fact that you had bile duct cancer, but you can change how you live the rest of your life by making healthy lifestyle choices.
Cholangiocarcinomas (CCCs) are malignancies of the biliary duct system that may originate in the liver and extrahepatic bile ducts, which terminate at the ampulla of Vater. CCCs are encountered in three anatomic regions: intrahepatic, extrahepatic (ie, perihilar), and distal extrahepatic.
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In bile duct cancer, the cancerous cells may release certain chemicals that can be detected using blood tests. These are known as tumour markers.. But tumour markers can also be caused by other conditions, so this test cant be used to say for certain whether or not you have bile duct cancer.. ...
Sigma-Aldrich offers abstracts and full-text articles by [Srilatha Badaboina, Hyoung-Woo Bai, Yun Hee Na, Chul-Hong Park, Tae Hoon Kim, Tae-Hoon Lee, Byung Yeoup Chung].
Foreword by Steve This is a good video clip that gives insight into the future direction of immunotherapy. As a Cholangiocarcinoma patient living in Australia and trying to understand the what, how and where tos of this immunotherapy wave is vitally important to my decision making.
Serum CEA, CA125, CA19-9, and CA724 levels for the diagnosis and staging of cholangiocarcinoma, Yawen Deng, Rihui Zhong, Xiaoying Xie, Xuxia Xiong, Jian He, Linhui Peng, Hua Zeng,
Liver Cancer is also often referred to as Hepatic Cancer and is cancer that starts in the Liver. Cancer that starts in the liver is actually less common than cancer that moves (metastasis) from other parts of the body into the liver.
Since airing this show, Pieter passed away due to his battle with a metastasis of bile duct cancer in both lungs. But rather than listen to this show with sadness, listen with a happy heart and lets celebrate Pieters life, and what he has accomplished. Thank you Pieter from the bottom of our hearts for your time on t...
2008 is soon a wrap, and its time to update my list of the different diagnostic and cancer treatment videos Ive filmed for the project over the last three and a half years. The project is almost completed, but I still have some filming related to liver-, pancreatic-, gall bladder- and bile duct cancer…
This phase II trial studies how well atezolizumab with or without cobimetinib works in treating patients with bile duct cancer that has spread to other places
Bile duct cystadenoma (8161) or biliary cystadenoma is a slow-growing tumour arising from bile ducts of the liver. The presence ... Cystadenoma (or "cystoma") is a type of cystic adenoma. When malignant, it is called cystadenocarcinoma. When not otherwise ... of endocrine cells in the tumour also indicates its origin from the glands surrounding the bile ducts. The incidence is 1-5 in ...
... malignant M8160/0 Bile duct adenoma (C22.1, C24.0) Cholangioma (M8160/3) Cholangiocarcinoma (C22.1, C24.0) Bile duct carcinoma ... benign Mesonephric adenoma Wolffian duct adenoma M9110/1 Mesonephric tumor, NOS Wolffian duct tumor M9110/3 Mesonephroma, ... Black adenoma Pigmented adenoma M8373/0 Adrenal cortical adenoma, clear cell (C74.0) M8374/0 Adrenal cortical adenoma, ... Infiltrating duct adenocarcinoma Duct adenocarcinoma, NOS Duct carcinoma, NOS Duct cell carcinoma Ductal carcinoma, NOS M8501/2 ...
Malignant neoplasm of liver and intrahepatic bile ducts. The most frequent forms are metastatic malignant neoplasm of liver) ... hepatic adenomas, and focal nodular hyperplasia (FNH). Chronic liver diseases like chronic hepatitis, chronic alcohol abuse or ... bile duct) spasm of sphincter of Oddi biliary cyst biliary atresia ICD-10 codes K70-K77: Liver Diseases [1]. ... of liver malignant neoplasm of the gallbladder malignant neoplasm of other parts of biliary tract extrahepatic bile duct ...
... to evaluate for adenomas of the common bile duct; small-bowel imaging when duodenal adenomas are detected or prior to colectomy ... may be necessary to evaluate for adenomas of the common bile duct; annual physical examination with palpation of the thyroid ... medulloblastoma] ,1%; Liver hepatoblastoma 1.6%; Bile ducts adenocarcinoma Low but increased; Stomach adenocarcinoma ,1% in ... Colectomy is usually advised when more than 20 or 30 adenomas or multiple adenomas with advanced histology have developed". " ...
... gastrointestinal Colon cancer Extrahepatic bile duct cancer Gallbladder cancer Gastric (stomach) cancer Gastrointestinal ... Bronchial adenomas/carcinoids Small cell lung cancer Mesothelioma Non-small cell lung cancer Pleuropulmonary blastoma Laryngeal ... which suggests that it has originated in the milk ducts.[citation needed] Benign tumors (which are not cancers) are usually ... Cerebral astrocytoma Glioblastoma Glioma Medulloblastoma Neuroblastoma Oligodendroglioma Pineal astrocytoma Pituitary adenoma ...
bile duct: Cholangiocarcinoma. *Klatskin tumor. *gallbladder: Gallbladder cancer. Pancreas. *exocrine pancreas: Adenocarcinoma ... Hepatocellular adenoma (also known as hepatic adenoma or hepadenoma) is a rare, benign liver tumor. It most commonly occurs in ... The histologic diagnosis of hepatic adenomas can be aided by reticulin staining. In hepatic adenomas, the reticulin scaffold is ... Pregnancy could cause the adenoma to grow faster, so patients with hepatic adenomas should avoid pregnancy.[10] ...
Injury to hepatocyte and bile duct cells lead to accumulation of bile acid inside the liver. This promotes further liver damage ... Hepatocellular carcinoma, angiosarcoma, and liver adenomas are the ones usually reported. Causes: Vinyl chloride, combined oral ... it can produce features similar to primary biliary cirrhosis due to progressive destruction of small bile ducts (vanishing duct ... diclofenac Liver injury leads to impairment of bile flow and cases are predominated by itching and jaundice. Histology may show ...
... common bile duct neoplasms MeSH C06.130.320.120 - bile duct neoplasms MeSH C06.130.320.120.280 - common bile duct neoplasms ... adenoma, islet cell MeSH C06.301.761.249.500 - insulinoma MeSH C06.301.761.500 - carcinoma, islet cell MeSH C06.301.761.500.124 ... MeSH C06.130.120.120 - bile duct neoplasms MeSH C06. - common bile duct neoplasms MeSH C06.130.120.123 - biliary ... bile duct neoplasms MeSH C06.301.120.250.250 - common bile duct neoplasms MeSH C06.301.120.401 - gallbladder neoplasms MeSH ...
... of the biliary system is called cholescintigraphy and is done to diagnose obstruction of the bile ducts by a ... Tc99m-sestamibi is used to detect parathyroid adenomas. To detect metastases/function of thyroid, the isotopes technetium-99m ... The radiopharmaceutical then goes into the bile ducts, the gallbladder, and the intestines. The gamma camera is placed on the ... It can also diagnose gallbladder diseases, e.g. bile leaks of biliary fistulas. In cholescintigraphy, the injected radioactive ...
... adenoma, bile duct MeSH C04.557.470.035.095 - adenoma, chromophobe MeSH C04.557.470.035.100 - adenoma, islet cell MeSH C04.557. ... bile duct neoplasms MeSH C04.588. - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ... adenoma MeSH C04.557.470.035.012 - acth-secreting pituitary adenoma MeSH C04.557.470.035.025 - adenoma, acidophil MeSH C04.557. ... adenoma, oxyphilic MeSH C04.557.470.035.155 - adenoma, pleomorphic MeSH C04.557.470.035.175 - adenoma, sweat gland MeSH C04.557 ...
... laparoscopic bile duct exploration, laparoscopic hernia repair, simultaneuse laproscopic surgery were defended. At present ... in villous adenomas is greater than that of others and has higher potential for malignancy (2017). Preliminary analysis of ... common bile duct exploration and resection, choledocho-duodenostomy, choledocho-yeyunostomy, fundoplication, liver, pancreas, ... In patients with cholecysto-choledocholithiasis one-stage laparoscopic common bile duct exploration and cholecystectomy has ...
Biliary cystadenoma and cystadenocarcinoma constitute less than 5% of intrahepatic cysts originating from the bile duct. ... It is a type of cystic adenoma (cystadenoma). Mucinous cystadenomata may arise in a number of locations; however, mucinous ...
Other primary sites that have been reported include colon, rectum, stomach, gallbladder, bile ducts, small intestine, urinary ... 2007) argued that continued use of non-malignant terms, i.e., adenoma, for those frequent cases with low-grade features (such ... Bradley states that an adenoma, by definition, is a tumor confined to the appendiceal mucosa with absolutely no evidence of ... proposed separating pseudomyxoma peritonei cases into two diagnostic categories: adenoma (disseminated peritoneal ...
Cholangiocarcinoma, or bile duct cancer Vaginal cancer Cancer of the urachus Stomach cancer Prostate cancer The term ... Next, they suggested that k-Ras becomes activated and the polyp becomes a small, benign adenoma. The adenoma, lacking the " ... Adenocarcinoma is the malignant counterpart to adenoma, which is the benign form of such tumors. Sometimes adenomas transform ... The gastroenterologist uses a colonoscopy to find and remove these adenomas and polyps to prevent them from continuing to ...
... and bile duct proliferation. The first reported isolation of 'Riddelliine' was done by Richard H. F. Manske, a chemist at the ... In mice, oral administration of riddelliine led to hemangiosarcomas in the liver in males and to broncho-alveolar adenomas and ... cellular carcinomas and/or adenomas in the liver and mononuclear cell leukemia. ...
... bile ducts, pancreas, and testicles. The polyps often bleeds and may cause obstruction that would require surgery. Any polyps ... villous adenoma): Tubular Adenoma: 5% risk of cancer Tubulovillous adenoma: 20% risk of cancer Villous adenoma: 40% risk of ... Neoplastic polyps of the bowel are often benign hence called adenomas. An adenoma is a tumor of glandular tissue, that has not ... villous adenoma which are long finger like projections on the surface, and tubulovillous adenoma which has features of both. ...
bile duct: Cholangiocarcinoma. *Klatskin tumor. *gallbladder: Gallbladder cancer. Pancreas. *exocrine pancreas: Adenocarcinoma ... as opposed to adenoma for example), not to the age of the affected person.[1] While the majority of the polyps found in ... AMHR2 (Persistent Müllerian duct syndrome II). *TGF beta receptors: Endoglin/Alk-1/SMAD4 (Hereditary hemorrhagic telangiectasia ...
bile duct: Cholangiocarcinoma. *Klatskin tumor. *gallbladder: Gallbladder cancer. Pancreas. *exocrine pancreas: Adenocarcinoma ... Nagata J, Kijima H, Hasumi K, Suzuki T, Shirai T, Mine T (June 2003). "Adenocarcinoma and multiple adenomas of the large ...
This results when a cancer in the head of the pancreas obstructs the common bile duct as it runs through the pancreas.[30] ... benign: Hepatocellular adenoma. *Cavernous hemangioma. *hyperplasia: Focal nodular hyperplasia. *Nodular regenerative ... Liver function tests can show a combination of results indicative of bile duct obstruction (raised conjugated bilirubin, γ- ... and attaching a loop of jejunum to the cystic duct to drain bile ("cholecysto-jejunostomy"). It can be performed only if the ...
bile duct: Cholangiocarcinoma. *Klatskin tumor. *gallbladder: Gallbladder cancer. Pancreas. *exocrine pancreas: Adenocarcinoma ... benign: Hepatocellular adenoma. *Cavernous hemangioma. *hyperplasia: Focal nodular hyperplasia. *Nodular regenerative ...
bile duct: Cholangiocarcinoma. *Klatskin tumor. *gallbladder: Gallbladder cancer. Pancreas. *exocrine pancreas: Adenocarcinoma ... benign: Hepatocellular adenoma. *Cavernous hemangioma. *hyperplasia: Focal nodular hyperplasia. *Nodular regenerative ...
bile duct: Cholangiocarcinoma. *Klatskin tumor. *gallbladder: Gallbladder cancer. Pancreas. *exocrine pancreas: Adenocarcinoma ... Adenomas/. adenocarcinomas. (8140-8429). Gastrointestinal. *tract: Linitis plastica. *Familial adenomatous polyposis. *pancreas ...
Histopathologically, an increased incidence of portal inflammatory cells infiltrate the liver and also bile duct proliferation ... of mice had lung adenomas(8% in control), 27% skin adenomas (0% in control), 11% malignant lymphomas (0% in control). Similar ...
... a bile acid-sensitive ion channel highly expressed in bile ducts". FASEB J. 26 (10): 4122-30. doi:10.1096/fj.12-207043. PMID ... Genetic variation in the key bile acid synthesis enzyme, CYP7A1, influenced the effectiveness of UDCA in colorectal adenoma ... The bile acid pool size is between 4-6 g, which means that bile acids are recycled several times each day. About 95% of bile ... These conjugated bile acids are often referred to as bile salts. The pKa of the unconjugated bile acids are between 5 and 6.5, ...
... common bile duct - comorbidity - compassionate use trial - complementary and alternative medicine - complete blood count (CBC ... tubulovillous adenoma - tumor - tumor antigen vaccine - tumor board review - tumor burden - tumor debulking - tumor ... bile duct - biliary - bilirubin - binding agent - bioavailable - biochanin A - biochemical reactions - biological response ... intrahepatic bile ducts - intrahepatic infusion - intralesional - intraluminal intubation and dilation - Intramuscular ...
... of the biliary system is called cholescintigraphy and is done to diagnose obstruction of the bile ducts by a ... Tc99m-sestamibi is used to detect parathyroid adenomas.[5] Thyroid[edit]. Main article: Radioactive iodine uptake test ... The radiopharmaceutical then goes into the bile ducts, the gallbladder, and the intestines. The gamma camera is placed on the ... the injected radioactive chemical is taken up by the liver and secreted into the bile. ...
155 Malignant neoplasm of liver and intrahepatic bile ducts 156 Malignant neoplasm of gallbladder and extrahepatic bile ducts ... of uncertain behavior of endocrine glands and nervous system 237.0 Pituitary gland and craniopharyngeal duct Pituitary adenoma ...
... a bile acid-sensitive ion channel highly expressed in bile ducts". FASEB J. 26 (10): 4122-30. doi:10.1096/fj.12-207043. PMID ... "Risk modification of colorectal adenoma by CYP7A1 polymorphisms and the role of bile acid metabolism in carcinogenesis". Cancer ... Primary bile acidsEdit. Bile acid synthesis occurs in liver cells, which synthesize primary bile acids (cholic acid and ... These conjugated bile acids are often referred to as bile salts. The pKa of the unconjugated bile acids are between 5 and 6.5,[ ...
It receives and stores bile, produced by the liver, via the common hepatic duct and releases it via the common bile duct into ... Adenoma - (plural adenomas or adenomata) is a benign tumor of epithelial tissue with glandular origin, glandular ... Bile duct - is any of a number of long tube-like structures that carry bile. Bile, required for the digestion of food, is ... which joins with the cystic duct (carrying bile to and from the gallbladder) to form the common bile duct, which opens into the ...
An important function is the production and control of bile acids. Too much bile acid can be toxic to cells and its synthesis ... The effect of vasopressin on the kidney tubules is to reabsorb water from the distal convoluted tubules and collecting ducts, ... over-production of parathyroid hormone by a parathyroid adenoma resulting in the typically features of hyperparathyroidism, ... Palmer, LG; Frindt, G (2000). "Aldosterone and potassium secretion by the cortical collecting duct". Kidney International. 57 ( ...
... bile ducts, kidneys, and spleen are imaged. However, sound waves are blocked by gas in the bowel and attenuated to differing ... A similar localization procedure with methylene blue, can be done to locate parathyroid adenomas at surgery. ...
Bile duct/ Other biliary tree. *Cholangitis *Primary sclerosing cholangitis. *Secondary sclerosing cholangitis ... Tubular Adenoma (Villous, Tubulovillous) Tubular glands with elongated nuclei (at least low-grade atypia) Yes ... Villous adenomas are commonly found in the rectal area and they are normally larger in size than the other two types of ... Traditional Serrated Adenoma Serrated crypts, often villous architecture, with cytologic atypia, eosinophilic cells Yes ...
... bile duct cancer, pancreatic cancer, small intestine cancer and colon cancer. In the colon, a field defect probably arises by ...
Segments of the duct and cysts that occur high in the neck are lined by stratified squamous epithelium, which is essentially ... The most common neoplasm affecting the thyroid gland is a benign adenoma, usually presenting as a painless mass in the neck.[64 ... perhaps by increasing the rate of secretion of cholesterol in bile.[27] ... The thyroid then descends in front of the pharyngeal gut as a bilobed diverticulum through the thyroglossal duct. Over the next ...
... common bile duct, urinary bladder of infants and young children or the vagina in females, typically younger than age 8. The ... Pleomorphic adenoma. *Mixed Müllerian tumor. *Mesoblastic nephroma. *Wilms' tumor. *Malignant rhabdoid tumour ...
疼痛或無痛性的黃疸(皮膚或眼白變黃):當腫瘤位於胰臟的頭部而造成總膽管(英語:common bile duct)阻
... most commonly develops in cells from the lining of milk ducts and the lobules that supply the ducts with milk.[1] ... especially an excess of black bile.[152] Alternatively, patients often saw it as divine punishment.[153] In the 18th century, a ... In cancer, the cells that would normally line up in an orderly way to make up the milk ducts become disorganized. Cell division ... Most breast cancers are derived from the epithelium lining the ducts or lobules, and these cancers are classified as ductal or ...
Gallbladder, bile duct. *Cholecystectomy. *Cholecystostomy. *ERCP. *Hepatoportoenterostomy. *Medical imaging: Cholangiography * ... It can detect larger adenomas and neoplasia with high specificity, but less sensitivity than conventional colonoscopy.[10] ...
Discrete localized enlargements of normal structures (ureters, blood vessels, intrahepatic or extrahepatic biliary ducts, ... Bile acids, at high levels in the colons of humans eating a high fat diet, also cause DNA damage and contribute to colon cancer ... and MGMT genes in colorectal cancer associated with adenoma-carcinoma sequence". Langenbecks Arch Surg. 396 (7): 1017-26. doi: ... "Carcinogenicity of deoxycholate, a secondary bile acid". Arch. Toxicol. 85 (8): 863-71. doi:10.1007/s00204-011-0648-7. PMC ...
Gallbladder, bile duct. *Cholecystectomy. *Cholecystostomy. *ERCP. *Hepatoportoenterostomy. *Medical imaging: Cholangiography * ... It is able to pick up 80 percent of colorectal cancer and 44 percent for adenoma , 1 centimeter, while gFOBT picks up 13 to 50 ...
Gallbladder, bile duct. *Cholecystectomy. *Cholecystostomy. *ERCP. *Hepatoportoenterostomy. *Medical imaging: Cholangiography * ... 2006). "Colonoscopic withdrawal times and adenoma detection during screening colonoscopy". New England Journal of Medicine. 355 ...
... obstructed bile duct, impaired liver function, and pancreatic disease The primary side effects of the drug are gastrointestinal ... "Aberrant crypt foci of the colon as precursors of adenoma and cancer". N Engl J Med. 339 (18): 1277-84. doi:10.1056/ ...
FREM1 Bile acid malabsorption, primary; 613291; SLC10A2 Bile acid synthesis defect, congenital, 2; 235555; AKR1D1 Bile acid ... TCF4 Pituitary adenoma, ACTH-secreting; 219090; AIP Pituitary adenoma, growth hormone-secreting; 102200; AIP Pituitary adenoma ... DCTN1 Persistent Mullerian duct syndrome, type I; 261550; AMH Persistent Mullerian duct syndrome, type II; 261550; AMHR2 ... PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, salivary gland pleomorphic; 181030; PLAG1 Adenomatous polyposis ...
An important function is the production and control of bile acids. Too much bile acid can be toxic to cells and its synthesis ... The effect of vasopressin on the kidney tubules is to reabsorb water from the distal convoluted tubules and collecting ducts, ... over-production of parathyroid hormone by a parathyroid adenoma resulting in the typically features of hyperparathyroidism, ... An example of this is in the control of bile acids in the liver. Some centers, such as the renin-angiotensin system, control ...
"Bile duct adenoma". Show Diagnoses. Week 181: Case 4. Diagnosis: Bile duct adenoma Week 15: Case 6. Diagnosis: Bile duct ...
Build: Fri Jul 27 09:23:34 EDT 2018 (commit: a5c8d99). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
INTRAHEPATIC BILE DUCT ADENOMA: A DIAGNOSTIC DILEMMA. Case Presentation: A 52-year-old male presented for an evaluation of ... Comments Off on INTRAHEPATIC BILE DUCT ADENOMA: A DIAGNOSTIC DILEMMA ...
The cell phenotype of so-called bile duct adenoma (BDA) was investigated immunohistochemically using monoclonal antibodies to ... The cell phenotype of so-called bile duct adenoma (BDA) was investigated immunohistochemically using monoclonal antibodies to ... was present in the cells forming the canals of Hering and normal bile ductules but not in interlobular and larger bile ducts. ...
Adenoma, Bile Duct / diagnosis. Adenoma, Bile Duct / metabolism. Bile Ducts, Extrahepatic / metabolism. Bile Ducts, ... Bile duct adenoma with oncocytic features.. *[MeSH-major] Adenoma, Bile Duct / pathology. Bile Duct Neoplasms / pathology. Bile ... A case of intrahepatic bile duct adenoma].. *[MeSH-major] Adenoma, Bile Duct / diagnosis. Bile Duct Neoplasms / diagnosis. Bile ... Bile Duct / complications. Adenoma, Bile Duct / diagnosis. Adult. Aged. Bile Duct Neoplasms / complications. Bile Duct ...
... adenoma, Focal Nodular Hyperplasia (FNH), Bile Duct Adenoma (BDA) and Lymphoproliferative Disorders (LPD) including ... and the size of the small bile ducts of the nodule was almost the same as that of the interlobular bile ducts in the background ... 2016) Bile duct adenoma in patient with chronic hepatitis C - As a benign neoplasm by pathological and imaging studies - Pathol ... We encountered two cases of pseudolymphoma of the liver and two of bile duct adenoma features of which were compared with those ...
MeSH-minor] Adenoma, Bile Duct / chemically induced. Adenoma, Bile Duct / pathology. Administration, Oral. Animals. Bile Duct ... Bile Duct / ultrasonography. Bile Duct Diseases / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, ... MeSH-minor] Adenoma, Liver Cell / diagnosis. Bile Duct Neoplasms / diagnosis. Bile Ducts, Intrahepatic / radiography. Carcinoma ... MeSH-minor] Adenoma, Liver Cell / ultrasonography. Bile Duct Neoplasms / ultrasonography. Bile Ducts, Intrahepatic. Carcinoma, ...
Two types of hepatic adenoma have been identified, including tumors of bile duct origin and tumors of liver cell origin. ... Hepatic adenoma is a rare, benign tumor of the liver. ... Hepatic adenomas of bile duct origin are usually smaller than 1 ... encoded search term (Hepatocellular Adenoma (Hepatic Adenoma) Imaging) and Hepatocellular Adenoma (Hepatic Adenoma) Imaging ... Two types of hepatic adenoma have been identified: tumors of bile duct origin and tumors of liver cell origin. ...
Tubulovillous Adenoma Colon or Rectum. Zenkers Diverticulum. Esophageal Stricture. Common Bile Duct Stones. ... gallbladder and bile ducts.. *Laparoscopic Surgery - Simple cases like weight loss, hernias and gallbladder problems as well as ...
Adenoma, Bile Duct/diagnosis , Bile Duct Neoplasms/diagnosis , Bile Ducts, Intrahepatic , Diffusion Magnetic Resonance Imaging/ ... Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Humans / Male / Adenoma, Bile Duct / Diffusion Magnetic Resonance Imaging / ... Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Humans / Male / Adenoma, Bile Duct / Diffusion Magnetic Resonance Imaging / ... RE: Diffusion-Weighted MRI in Intrahepatic Bile Duct Adenoma Arising from the Cirrhotic Li ...
... we report a rare case of bile duct adenoma arising from choledochal cyst with anomalous union of pancreaticobiliary duct (AUPBD ... Adenoma, Villous/diagnosis , Bile Duct Neoplasms/diagnosis , Cholangiopancreatography, Magnetic Resonance , Choledochal Cyst/ ... A Case of Early Bile Duct Cancer Arising from Villous Adenoma in Choledochal Cyst / 대한소화기학회지 ... A Case of Early Bile Duct Cancer Arising from Villous Adenoma in Choledochal Cyst ...
What is cholangiocellular adenoma? Meaning of cholangiocellular adenoma medical term. What does cholangiocellular adenoma mean? ... Looking for online definition of cholangiocellular adenoma in the Medical Dictionary? cholangiocellular adenoma explanation ... pertaining to the bile ducts.. cholangiocellular adenoma. solid or cystic; may be neoplastic or congenital or acquired cystic ... a variety of bile duct adenoma in which the tumor is composed of multilocular cystic structures lined with epithelium ...
Adenoma / pathology * Adolescent * Adult * Bile Duct Neoplasms / pathology * Bile Ducts / abnormalities * Carcinoma, ...
Resolution of Bile Duct Adenoma over Follow-up Period; A Case Report. ...
Gut microbiota, bile acid metabolism, and cytokines have not been ... ... a type of bile duct cancer, has a high mortality rate. ... Adenoma, Bile Duct. A benign tumor of the intrahepatic bile ... Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, ... in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cirrhosis ...
bile duct adenoma. *cholangioadenoma. cystadenoma. *cystoma. mucinous cystadenocarcinoma. *pseudomucinous cystadenocarcinoma. ... and neuronal cell adhesion molecule staining in focal nodular hyperplasia and hepatic adenoma. (PMID: 19157505) Ahmad I … Jain ... cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts ...
These are classified as liver cell adenomas or bile duct adenomas. In addition, a third type of tumor occurs. This lesion is ... MIXED ADENOMA (HAMARTOMA) OF THE LIVER: REPORT OF A CASE(MIXED ADENOMA (HAMARTOMA) OF THE LIVER: REPORT OF A CASE*) ROBERT M. ... MIXED ADENOMA (HAMARTOMA) OF THE LIVER: REPORT OF A CASE(MIXED ADENOMA (HAMARTOMA) OF THE LIVER: REPORT OF A CASE*). Ann Intern ... Primary benign liver tumors may arise from either the liver cells or the bile duct epithelium. ...
Resolution of Bile Duct Adenoma over Follow-up Period; A Case Report. ...
Hepatic Adenoma. *Hepatic Cysts. *Bile Duct Hamartomas. *Biliary Cystadenoma. *Hepatic Abscess. *Hepatocellular Carcinoma ... Pathways of Bile Acid Synthesis From Cholesterol. *Defects in Bile Acid Synthesis Causing Metabolic Liver Disease and Syndromes ... 2: Bile Acids and Bile Flow: New Functions of Old Molecules. *Introduction ...
Progressive inflammation and fibrosis of large intra and extra hepatic bile ducts ... Along with bile duct adenoma. 6 Liver cell adenoma more common in ...
Contributions to the surgery of the passage, especially the common bile duct HALSTED WS. ... 十二指腸乳頭部腺腫に対し乳頭全切除を施行した1例 [in Japanese] A CASE OF TOTAL PAPILLECTOMY FOR ADENOMA OF THE DUODENAL PAPILLA [in Japanese] * * 石井 要 ... THE USEFULNESS OF ENDOSCOPIC RESECTION OF THE ADENOMA OF THE PAPILLA OF VATER [
Bile duct adenoma Focal nodular hyperplasia Hemangioma Hepatocellular adenoma Am I Correct?. ... Benign bile duct adenomas are rare, inconsequential, and usually detected incidentally. They are sometimes mistaken for ... Hepatocellular adenoma. Hepatocellular adenoma is the most important benign tumor to recognize. It occurs primarily in women of ... Adenomas due to contraceptive use may regress if the contraceptive is stopped. If the adenoma does not regress or if it is ...
Bile duct adenoma Focal nodular hyperplasia Hemangioma Hepatocellular adenoma Am I Correct?. ...
... bile duct adenoma; biliary papillomatosis; Clonorchis sinensis infection; and Thorotrast (thorium dioxide) exposure.38-39 The ... Craig J, Peters R, Edmondson H. Tumors of the liver and intrahepatic bile ducts. In: Hartman H, Sobin L, eds. Atlas of Tumor ... Unlike fibrolamellar HCC, the central scar in FNH is not a true scar, but represents a confluence of blood vessels, bile ducts ... Hepatic adenoma. Although the precise pathogenic mechanism leading to hepatic adenomas is still unknown, the use of estrogen- ...
Diseases associated with S100A4 include Follicular Adenoma and Bile Duct Adenocarcinoma. Among its related pathways are Ca, ...
... are also known as hepatic adenomas or liver cell adenomas. They are rare, benign tumors of presumable epithelial origin and ... Hepatic adenomas consist of sheets of hepatocytes without bile ducts or portal areas. Kupffer cells, if present, are reduced in ... Hepatocellular adenomas (HCAs) are also known as hepatic adenomas or liver cell adenomas. They are rare, benign tumors of ... encoded search term (Hepatocellular Adenoma) and Hepatocellular Adenoma What to Read Next on Medscape. Related Conditions and ...
Papillary adenoma of the distal common bile duct (1999) * Mucin-producing tumors of the pancreas : clinicopathological features ... Metastatic Seeding of Bile Duct Carcinoma in the Transhepatic Catheter Tract: Report of a Case (1999) ...
Adenoma. *Focal nodular hyperplasia. *Hemangioma. *Stricture (narrowing) or obstruction (blockage) of the bile ducts ... Hepatobiliary surgery at the Montefiore Comprehensive Liver Program encompasses treatment for the liver, bile ducts and ...
Adrenal Adenoma. *Adrenal Nodule. *Axillary Abscess. *Bile Duct Obstruction. *Biliary Colic. *Choledocholithiasis ...
Bile duct adenoma. (A) Brush cytology showing a loosely cohesive and crowded epithelial group exhibiting malignant nuclear ... Daignostic value of brush cytology in the diagnosis of bile duct carcinoma: a study in 65 patients with bile duct strictures. ... Some studies have examined only pancreatic duct14-16 or bile duct strictures,11, 17 although most have included a variable ... Three patients in our series with positive cytology proved to have adenomas involving the ampulla or distal common bile duct, ...
  • In general, the incidence of BDA and LPD is relatedly small compared to other hypervascular liver tumors such as HCC, CoCC, hemangioma, adenoma and FNH. (
  • Two types of hepatic adenoma have been identified: tumors of bile duct origin and tumors of liver cell origin. (
  • Primary benign liver tumors may arise from either the liver cells or the bile duct epithelium. (
  • Neuroendocrine tumors are rare cancers that develop in a neuoroendocrine cell rather than a cell lining a duct or bowel lumen. (
  • Fischer 344/N rats and B6C3F l mice receiving MDA as 4,4′-methylenedianiline dihydrochloride ad libitum in drinking water for 2 years developed thyroid follicular cell carcinomas and adenomas, C-cell adenomas of the thyroid, hepatocellular carcinomas and adenomas, alveolar bronchiolar adenomas, malignant lymphomas, and benign tumors of the adrenal gland. (
  • The survival rate for dogs with neuroendocrine tumors and bile duct carcinoma after surgery is not good due to the risk of cancer spreading to other parts of the body and reoccurrence. (
  • Less common tumors can spread (metastasis) such as bile duct carcinomas and neuroendocrine tumors. (
  • Papillary tumors of the intrahepatic bile ducts are characterized by intraluminal growth, sometimes in papillary masses with bile duct obstruction and dilatation. (
  • Papillary tumors generally produce a large amount of mucin and so they may occasionally impede the flow of the bile juice and cause a severe ductal dilatation. (
  • Laparoscopic hepatectomy has been widely performed for patients with benign liver tumors such as hepatic hemangioma, focal nodular hyperplasia, and hepatic adenoma. (
  • 142330 ]. Hepatic adenomas are rare benign liver tumors of presumable epithelial origin that develop in an otherwise normal liver. (
  • The tumors that developed in the extrahepatic bile duct included 10 adenomas and 55 early carcinomas in 56 of the 156 hamsters killed. (
  • Carcinomas coexisting with or in adenoma were evident in 12 (22%) tumors, 11 of which were polypoid. (
  • These findings support the concept of an adenoma-carcinoma sequence in most polypoid tumors of the extrahepatic bile duct. (
  • Malignant tumors (adenocarcinomas) are much more common than benign tumors (adenomas). (
  • There are two types of bile duct tumors that affect dogs and cats. (
  • Benign biliary adenomas are the most prevalent type of liver tumor in cats, accounting for over 50 percent of all feline primary liver tumors. (
  • This means that many adenoma tumors are identified as incidental findings in patients with no liver symptoms. (
  • The clinical importance and natural history of these incidental adenoma tumors is not fully understood, and there is a need for optimal management strategies in such patients. (
  • Hepatobiliary tumors are basically of 4 types like hepatocellular, bile duct, neuroendocrine (or carcinoid), and mesenchymal (sarcoma). (
  • Hepatocellular tumors - They comprise hepatocellular carcinoma, hepatocellular adenoma and hepatoblastoma. (
  • Bile duct adenoma (biliary cystadenoma)- The bile duct tumors consist of two type- bile duct adenoma and carcinoma. (
  • Bile duct carcinoma (cholangiocarcinoma)- Bile duct carcinomas account for 22%-41% of all malignant liver tumors in dogs. (
  • Noncancerous tumors in the liver such as adenoma and hemangioma. (
  • Characteristically, tumors with arterial hypervascularization may be benign -adenomas or FNH- or malignant, such as hepatocellular carcinoma, and metastases from neuroendocrine tumors or hypernephroma. (
  • Benign liver tumors like a hepatic adenoma develop when the liver cells multiply excessively to form a mass. (
  • Hepato-Pancreato-Biliary Surgery - General surgical treatment for benign and malignant diseases of the liver, pancreas, gallbladder and bile ducts. (
  • Hepatobiliary surgery at the Montefiore Comprehensive Liver Program encompasses treatment for the liver, bile ducts and gallbladder. (
  • Biliary and pancreatic duct strictures are most often caused by inflammatory or neoplastic disorders involving the pancreas, biliary tree, gallbladder, or ampulla. (
  • These changes may lead to non-cancerous (benign) conditions such as bile stones or inflammation of the gallbladder (cholecystitis). (
  • The normal common bile duct finding means the liver, pancreas and gallbladder empty in to a normal duct that drains into the intestine . (
  • Dilated bile duct can be a sign of pancreatic, bile duct, liver,or gallbladder disease. (
  • Gallbladder - gallbladder stones (biliary colic), bile duct stones, inflammation of the gallbladder (cholecystitis) or ducts (cholangitis) due to infectious or non-infectious causes. (
  • Bile ducts or gallbladder obstruction that causes inflammation within the liver or back up of bile. (
  • Based on the organs lying in this region, epigastric pain is therefore usually due to liver, pancreas, gallbladder, bile duct, stomach, duodenum and/or abdominal aorta conditions. (
  • Waste and other byproducts from the liver are excreted through bile which is stores in the gallbladder temporarily. (
  • Gallstones are tiny hard masses that form within the gallbladder from bile. (
  • It can then become obstructed in the gallbladder duct or bile duct. (
  • With the recent advances in diagnostic imaging, an increasing number of hypervascular hepatic nodules such as Hepatocellular Carcinoma (HCC), Cholangiolocellular Carcinoma (CoCC), Bile Duct Adenoma (BDA) and Lymphoproliferative Disorders (LPD) including pseudolymphoma have been detected. (
  • On histological examination, adenoma with focal carcinoma change arising from choledochal cyst was diagnosed. (
  • Called also bile duct carcinoma. (
  • Moreover, a central scar may be found in some patients with fibrolamellar hepatocellular carcinoma , hepatic adenoma , or intrahepatic cholangiocarcinoma . (
  • Synergic effect of photodynamic therapy using talaporfin sodium with conventional anticancer chemotherapy for the treatment of bile duct carcinoma. (
  • BACKGROUND: Photodynamic therapy (PDT) is an effective laser treatment for locally treating advanced bile duct carcinoma (BDC). (
  • Bile duct involvement by hepatocellular carcinoma: A rare occurrence and poor prognostic indicator in bile duct brushing samples. (
  • Papillomatosis of the bile ducts: papilloma-carcinoma sequence. (
  • The adenoma-carcinoma sequence applies to epithelial tumours of the papilla of Vater. (
  • Nakajo S, Yamamoto M, Tahara E. Morphometrical analysis of gall-bladder adenoma and adenocarcinoma with reference to histogenesis and adenoma-carcinoma sequence. (
  • Bile duct cancer, or biliary carcinoma, is a common type of liver cancer in both cats and dogs, primarily seen in pets over the age of 10. (
  • One is biliary adenoma, which is a benign tumor, and the other is biliary carcinoma, which is malignant (cancerous). (
  • The topic of today's discussion is the other type of bile duct tumor, which is biliary carcinoma. (
  • Biliary or bile duct carcinoma is the most common type of liver cancer in cats and the second most common in dogs. (
  • Biliary carcinoma usually originates in the cellular lining of the liver bile ducts. (
  • The cause of bile duct carcinoma has been attributed to trematodes (a kind of parasite). (
  • However, this is not believed to be a biggest contributor, since bile duct carcinoma also occurs in places that are outside the normal distribution of trematodes. (
  • Bile duct carcinoma can either intrahepatic (inside the liver), extrahepatic (outside the liver) or within the gall bladder. (
  • Thus, a history of oral contraceptive use in a young woman suggests hepatocellular adenoma, cirrhosis is a preneoplastic condition for hepatocellular carcinoma, and sclerosing cholangitis predisposes to cholangiocarcinoma. (
  • The most frequent forms are metastatic malignant neoplasm of liver) liver cell carcinoma hepatocellular carcinoma hepatoma cholangiocarcinoma hepatoblastoma angiosarcoma of liver Kupffer cell sarcoma other sarcomas of liver Benign neoplasm of liver include hepatic hemangiomas, hepatic adenomas, and focal nodular hyperplasia (FNH). (
  • Ampullary adenomas have the potential for malignant transformation to ampullary carcinomas by an adenoma-to-carcinoma sequence as seen elsewhere in the gastrointestinal tract. (
  • Characterization of gut microbiota, bile acid metabolism, and cytokines in intrahepatic cholangiocarcinoma. (
  • DLEC1 methylation is associated with a better clinical outcome in patients with intrahepatic cholangiocarcinoma of the small duct subtype. (
  • Intrahepatic cholangiocarcinoma is a complex disease with three different histologic subtypes, the large duct, small duct, and bile ductular types. (
  • The most common type of cholangiocarcinoma starts in the gland cells of the lining and is called adenocarcinoma of the bile duct. (
  • A cancer that arises in the ducts of the liver is called cholangiocarcinoma . (
  • Discussed here is the differential diagnosis of HCC in terms of pseudolymphoma and bile duct adenoma and the importance of avoiding overtreatment of benign lesions. (
  • Although CT scanning, MRI, and nuclear medicine studies may help characterize lesions as adenomas, the findings are frequently nonspecific, and biopsy and/or resection may be necessary. (
  • Hemangiomas, focal nodular hyperplasias (FNH), and adenomas (HCA) are the most commonly encountered solid benign lesions. (
  • Biliary and pancreatic duct lesions are not always readily accessible to biopsy, and cytological techniques have become the initial diagnostic modality in many cases. (
  • Increased incidences of liver lesions occurred in 300 and 1,000 mg/kg males and females and hepatocellular adenoma occurred in one 1,000 mg/kg male. (
  • Lesions can be well defined and demarcated from the bile duct wall. (
  • Wittekind C, Tannapfel A. Adenoma of the papilla and ampulla-premalignant lesions? (
  • These include hemangioma, focal nodular hyperplasia, hepatocellular adenoma, and other less commonly seen lesions ( Table 57-1 ). (
  • Similarly, it may be essential to distinguish between liver adenoma and FNH, or to establish the nature of a number of atypical lesions. (
  • En bloc resection is recommended for lesions confined to the papilla. (
  • Wistar rats receiving a single injection of 2,2′-dihydroxy-N-nitrosodipropylamine (a tumor initiator) followed by 4,4′-methylenedianiline (MDA) in the diet for 19 weeks, developed thyroid follicular cell carcinomas and follicular cell and papillary adenomas. (
  • In a study in rats fed hexachlorobenzene in the diet, hepatomas, hepatocellular carcinomas, bile-duct adenomas and renal-cell adenomas were observed [ref: 8]. (
  • We then investigated the histomorphological characteristics of the adenomas and early carcinomas induced in the extrahepatic bile duct. (
  • This widening may occur as a result of the formation of fluid-filled sacs or lumps (choledochal cysts) in the bile ducts. (
  • Examples of benign liver masses includehepatocellular hyperplasia, hepatocellular adenomas and benign hepatic cysts. (
  • Hydatid cysts may become complicated in one third of cases, rupturing into the peritoneum or into the pleural space or bile tract. (
  • Bile duct or liver cysts are fluid filled masses that form in an around the bile duct or liver. (
  • Crozer-Keystone's hepatobiliary specialists treat patients diagnosed with cancer or other diseases of the liver, biliary ducts of the liver and the pancreas. (
  • Diseases associated with S100A4 include Follicular Adenoma and Bile Duct Adenocarcinoma . (
  • The three adenomas identified on brush cytology could not be distinguished from adenocarcinoma morphologically. (
  • Keshgegian AA, Enterline HT (1978) Gardner's syndrome with duodenal adenomas, gastric adenomyoma and thyroid papillary-follicular adenocarcinoma. (
  • She had received common bile duct (CBD) exploration and choledocholithotomy and cholecystectomy 3 months earlier under the diagnosis of multiple CBD stones. (
  • One hundred and sixty patients (39.4%) had benign strictures, most often as a result of chronic pancreatitis and bile duct stones. (
  • Bilateral lung nodules,Atelectasis prior papilloma thyroid CA.Pituitary Adenoma,Chiari Malformation,FMD,enlarged common bile duct no stones. (
  • you still can form stones within the common bile duct. (
  • There may also be localized accumulation of pus (abscess), stones that develop inside the bile ducts (intraductal lithiasis), abdominal pain, and/or fever. (
  • No bile duct stones were found after the exploration. (
  • Sometimes stones can form in the bile duct. (
  • Abdominal enhanced computed tomography scan showed intrahepatic and extrahepatic bile duct dilatation with liver atrophy of left lobe. (
  • Ultrasonography revealed intrahepatic and extrahepatic bile duct dilatation with viscous fluid, tubular adenoma? (
  • Mild intrahepatic biliary duct dilatation. (
  • We do not know why the scan was ordered but mild intrahepatic biliary duct dilatation may be completely normal for this patient. (
  • What does diffuse dilatation of common bile duct & mild dilatation of hepatic ducts mean? (
  • Caroli disease is a rare inherited disorder characterized by abnormal widening (dilatation) of the ducts that carry bile from the liver (intrahepatic bile ducts). (
  • In most cases, the isolated or simple form is characterized by widening of the bile ducts (dilatation or ectasia). (
  • Both intra- and extrahepatic duct dilatation may be seen. (
  • Papillary neoplasms of the bile duct that mimic biliary stone disease. (
  • Burhans R, Myers RT (1971) Benign neoplasms of the extra hepatic biliary ducts. (
  • Gall bladder and removal of stone at the junction of cystic duct and cbd via open surgery. (
  • Usually a gallstone causing obstruction of the common bile duct can cause sudden painful jaundice , sometimes with associated cholangitis (infection of the bile) This requires drainage and extraction of the stone from the common bile duct with a procedure call ERCP . (
  • Due to obstruction and mucin secretion, the dilated bile ducts may not completely fill with contrast material. (
  • These are classified as liver cell adenomas or bile duct adenomas. (
  • many null-cell adenomas are of this type. (
  • On review of published studies there is evidence that 10% of liver cell adenomas progress to liver cancer. (
  • Oral contraceptive-induced liver cell adenomas are reversible if oral contraceptives are discontinued within a certain time period. (
  • Cholangitis is inflammation of the bile duct usually due to an infection. (
  • Discussed here is the differential diagnosis of small HCC through imaging studies focused on pseudolymphoma and bile duct adenoma. (
  • In this study, we identified new biomarkers, including gut microbiota, bile acids, and inflammatory cytokines, for diagnosis of ICC and prediction of VI in patients with ICC. (
  • So, the definitive diagnosis of intraductal papillary mucinous tumor of bile ducts was made on surgical resected material. (
  • Two Cases of Villous Adenoma of the Common Bile Duct: Endoscopic Diagnosis and Treatment. (
  • Postoperative pathological diagnosis was intrahepatic bile duct papillary mucinous cystadenoma. (
  • Despite significant progress in imaging techniques of the liver such as MRI scans, a definite diagnosis of adenoma is by excision biopsy. (
  • The cell phenotype of so-called bile duct adenoma (BDA) was investigated immunohistochemically using monoclonal antibodies to two recently identified antigens (designated D10 and 1F6) extracted from human liver and cultured biliary epithelium. (
  • Most often, bile duct cancer starts in the cells of the inner lining (epithelium) of the bile duct. (
  • It is usually a single lesion of serous contents lined by cuboidal, biliary type epithelium with no communication with bile ducts (4-6). (
  • The so-called bile duct adenoma is a peribiliary gland hamartoma. (
  • M8140/0) Adenoma, NOS M8140/1 Atypical adenoma Bronchial adenoma, NOS (C34. (
  • The bile ducts are tubes that carry bile from the liver to the first part of the small intestine (duodenum). (
  • Both forms of Caroli disease are characterized by abnormal widening of the ducts that carry bile from the liver (intrahepatic bile ducts). (
  • They can also lead to non-cancerous tumours such as bile duct adenoma. (
  • Dowdy GS, Olin WG, Shelton EL, Walderon GW (1971) Benign tumours of the extra hepatic bile ducts. (
  • in hamsters of each sex, it produced hepatomas, liver haemangioendotheliomas and thyroid adenomas. (
  • Adenomas occur in the skin (sweat gland) oropharynx, intestine, bile duct, mammary gland, kidney and thyroid gland. (
  • Dr. Raijman identified the lesion as a villous adenoma of the bile duct, which has a high possibility of turning into cancer. (
  • The bile duct is the duct the drains bile out of the river and into the intestines. (
  • Adenomatoid nodule - fibrotic stroma and glands ( adenoma ). (
  • Ampullary adenoma. (
  • Patients diagnosed with an ampullary adenoma have three therapeutic options: pancreaticoduodenectomy, surgical local excision or endoscopic ampullectomy (EA). (
  • Antigen 1F6 was present in the cells forming the canals of Hering and normal bile ductules but not in interlobular and larger bile ducts. (
  • Proliferating bile ductules associated wit. (
  • Rarely, adenomas manifest as peritonitis and shock due to rupture and intraperitoneal hemorrhage. (
  • Spontaneous rupture and hemorrhage most likely do not exist, and most of the reports concerning bleeding are old case reports that involve misdiagnoses of telangiectatic FNH, which has been recently reclassified as inflammatory hepatic adenoma. (
  • Pregnancy often stimulates rapid growth in liver adenomas with risk of potentially fatal spontaneous rupture. (
  • Unfortunately, bile duct cancer is very aggressive, with metastasis (spreading of the disease) occurring in about 80 percent of both dogs and cats. (
  • Sadly, even with successful surgery and little to no metastasis of the cancer throughout the pet's body, the prognosis for pets with bile duct cancer is very poor. (
  • Hepatocellular adenoma (HCA), or hepatic adenoma, is the third leading benign liver tumor and has bleeding and malignant transformation tendencies. (
  • A liver adenoma is an encapsulated liver tumor (has a capsule around it) and it does not contain bile ducts. (
  • Complications of the disease include blockage of bile within the bile ducts. (
  • Radiologic features of papillary adenoma and papillomatosis of the biliary tract. (
  • Glucose-6-phosphate regulates hepatic bile acid synthesis in mice. (
  • Because adenoma has a risk of bleeding and malignant transformation, surgical excision is usually done for solitary liver adenomas. (
  • What is bile duct cancer? (
  • Bile duct cancer starts in the cells of the bile duct. (
  • But in some cases, changes to bile duct cells can cause bile duct cancer. (
  • Rare types of bile duct cancer can also develop. (
  • Is Your Pet Sleeping on a Hotbed for Bile Duct Cancer? (
  • A dog or cat with bile duct cancer usually has a round or swollen abdomen caused by an enlarged liver and/or fluid in the abdomen. (
  • Liver adenoma has the possibility of severe outcomes such as bleeding and transformation into liver cancer. (
  • This often results in the adenoma shrinking, but there is still a risk of transformation into liver cancer. (
  • With prolonged oral contraceptive usage pre-cancerous changes (dysplastic foci) develop within the liver cell adenoma that may progress to liver cancer. (
  • Regular and long term medical supervision is vital because even complete disappearance of the adenoma does not prevent the later development of liver cancer, which has been observed five years after cessation of oral contraceptive usage and regression of the adenoma. (
  • After radiologic evaluation, an incisional biopsy was performed and then the mass was excised en bloc. (
  • It is often difficult to correctly diagnose patients who present with dilation of the bile duct. (
  • MRCP "Persistent mild dilation of the central intrahepatic duct. (
  • No dilation of common bile duct. (
  • GB like symptoms.US-distal dilation of CBD 7.7mm.MRCP-mild prominence of pancreatic duct.Dense adhesions between GB & abdominal wall. (
  • Laparoscopic anatomical left hepatectomy and common bile duct exploration were performed. (
  • hepatocellular adenoma a large, fleshy, hypervascular tumor of the liver occurring chiefly in women of childbearing age and associated with oral contraceptive use. (
  • The isolated or simple form of Caroli disease is characterized by frequent recurring inflammation of the bile ducts inside the liver. (