Basophils: Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.Adenoma: A benign epithelial tumor with a glandular organization.Basophil Degranulation Test: An in vitro test used in the diagnosis of allergies including drug hypersensitivity. The allergen is added to the patient's white blood cells and the subsequent histamine release is measured.Adenoma, Pleomorphic: A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)Histamine Release: The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects.Adenoma, Villous: An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.Adrenocortical Adenoma: A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.Immunoglobulin E: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Adenoma, Liver Cell: A benign epithelial tumor of the LIVER.Adenoma, Chromophobe: A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.Receptors, IgE: Specific molecular sites on the surface of B- and T-lymphocytes which combine with IgEs. Two subclasses exist: low affinity receptors (Fc epsilon RII) and high affinity receptors (Fc epsilon RI).Growth Hormone-Secreting Pituitary Adenoma: A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Antigens, CD63: Ubiquitously-expressed tetraspanin proteins that are found in late ENDOSOMES and LYSOSOMES and have been implicated in intracellular transport of proteins.Colonic Polyps: Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.ACTH-Secreting Pituitary Adenoma: A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.Adenoma, Basophil: A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)Adenoma, Acidophil: A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)Colonoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the colon.Adenomatous Polyps: Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.Prolactinoma: A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.Mast Cells: Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.Interleukin-3: A multilineage cell growth factor secreted by LYMPHOCYTES; EPITHELIAL CELLS; and ASTROCYTES which stimulates clonal proliferation and differentiation of various types of blood and tissue cells.Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Antibodies, Anti-Idiotypic: Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.Anaphylaxis: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.Eosinophils: Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.Adenomatous Polyposis Coli: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.Allergens: Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Leukotriene C4: The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)Histamine: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.Strongylida Infections: Infections with nematodes of the order STRONGYLIDA.Interleukin-4: A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.Nippostrongylus: A genus of intestinal nematode parasites belonging to the superfamily HELIGMOSOMATOIDEA, which commonly occurs in rats but has been experimentally transmitted to other rodents and rabbits. Infection is usually through the skin.Desensitization, Immunologic: Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.Peanut Hypersensitivity: Allergic reaction to peanuts that is triggered by the immune system.Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)Cell Degranulation: The process of losing secretory granules (SECRETORY VESICLES). This occurs, for example, in mast cells, basophils, neutrophils, eosinophils, and platelets when secretory products are released from the granules by EXOCYTOSIS.Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.Filarioidea: A superfamily of nematodes of the suborder SPIRURINA. Its organisms possess a filiform body and a mouth surrounded by papillae.Genes, APC: Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.Anti-Allergic Agents: Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)Hyperparathyroidism: A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Betula: A plant genus of the family BETULACEAE. The tree has smooth, resinous, varicolored or white bark, marked by horizontal pores (lenticels), which usually peels horizontally in thin sheets.Colonic Neoplasms: Tumors or cancer of the COLON.Skin Tests: Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Th2 Cells: Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.Hypersensitivity, Immediate: Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.Antigens, Plant: Substances found in PLANTS that have antigenic activity.Adrenal Gland Neoplasms: Tumors or cancer of the ADRENAL GLANDS.Pituitary ACTH Hypersecretion: A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Complement C5a: The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Receptors, CCR3: CCR receptors with specificity for CHEMOKINE CCL11 and a variety of other CC CHEMOKINES. They are expressed at high levels in T-LYMPHOCYTES; EOSINOPHILS; BASOPHILS; and MAST CELLS.Hyperaldosteronism: A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.Sphenoid Bone: An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).N-Formylmethionine Leucyl-Phenylalanine: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.Interleukin-13: A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.Food Hypersensitivity: Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.
(1/9) An R201H activating mutation of the GNAS1 (Gsalpha) gene in a corticotroph pituitary adenoma.

In the pituitary gland, activating mutations of the GNAS1 (Gsalpha) gene at Gln227 have been identified in adrenocorticotrophin secreting, growth hormone secreting, and prolactin secreting adenomas. To date, mutations at the codon encoding R201, typically underlying the McCune-Albright syndrome and isolated fibrous dysplasia of bone, have been demonstrated only in growth hormone secreting pituitary adenomas. In this study, a polymerase chain reaction amplified target sequence in exon 8 of the GNAS1 gene was sequenced, identifying the first R201 mutation seen in an isolated basophilic adenoma which generated Cushing's disease in a child. This case adds Cushing's disease to the range of human diseases caused by R201 mutations of the GNAS1 gene.  (+info)

(2/9) A 2-year dose-response study of lesion sequences during hepatocellular carcinogenesis in the male B6C3F(1) mouse given the drinking water chemical dichloroacetic acid.

Dichloroacetic acid (DCA) is carcinogenic to the B6C3F(1) mouse and the F344 rat. Given the carcinogenic potential of DCA in rodent liver and the known concentrations of this compound in drinking water, reliable biologically based models to reduce the uncertainty of risk assessment for human exposure to DCA are needed. Development of such models requires identification and quantification of premalignant hepatic lesions, identification of the doses at which these lesions occur, and determination of the likelihood that these lesions will progress to cancer. In this study we determined the dose response of histopathologic changes occurring in the livers of mice exposed to DCA (0.05-3.5 g/L) for 26-100 weeks. Lesions were classified as foci of cellular alteration smaller than one liver lobule (altered hepatic foci; AHF), foci of cellular alteration larger than one liver lobule (large foci of cellular alteration; LFCA), adenomas (ADs), or carcinomas (CAs). Histopathologic analysis of 598 premalignant lesions revealed that (a)) each lesion class had a predominant phenotype; (b)) AHF, LFCA, and AD demonstrated neoplastic progression with time; and (c)) independent of DCA dose and length of exposure effects, some toxic/adaptive changes in non-involved liver were related to this neoplastic progression. A lesion sequence for carcinogenesis in male B6C3F(1) mouse liver has been proposed that will enable development of a biologically based mathematical model for DCA. Because all classes of premalignant lesions and CAs were found at both lower and higher doses, these data are consistent with the conclusion that nongenotoxic mechanisms, such as negative selection, are relevant to DCA carcinogenesis at lower doses where DCA genotoxicity has not been observed.  (+info)

(3/9) Analysis of pituitary hormones and chromogranin A mRNAs in null cell adenomas, oncocytomas, and gonadotroph adenomas by in situ hybridization.

To study the relationship between null cell adenomas, oncocytomas and gonadotroph adenomas, we analyzed 32 surgically removed formalin-fixed paraffin-embedded pituitary tumors for the expression of pituitary hormone messenger RNAs (mRNAs) by in situ hybridization (ISH). Most tumors were also analyzed for chromogranin A mRNA. To identify the cell type constituting the tumors and to assess hormone content, all tumors were investigated by histology, transmission electron microscopy and immunohistochemistry. Most null cell adenomas (6/11) and gonadotroph adenomas (9/10) expressed the mRNAs for alpha-subunit of glycoprotein hormones whereas only 2/11 oncocytomas expressed alpha-subunit mRNA. FSH beta and/or LH beta mRNA were present in most null cell and gonadotroph adenomas but only in a few oncocytomas. Prolactin (PRL) mRNA was detected in two null cell tumors and in one gonadotroph adenoma, whereas GH and POMC mRNA were present in one null cell adenoma. Chromogranin A mRNA, which codes for the major secretory granule protein, was present in 25/26 tumors including all tumors that were negative for pituitary hormone mRNAs, indicating adequate preservation of specific mRNA transcripts in the paraffin-embedded sections of tumor cells. These results indicate that null cell adenomas and gonadotroph adenomas are closely related neoplasms and that oncocytomas may represent a functionally defective form of null cell adenoma characterized by mitochondrial abundance, which has retained the capacity to synthesize the major secretory granule protein chromogranin A. Although the cytogenesis of null cell adenomas and oncocytomas is not clear, it can be suggested that these two tumor types are derived from a pluripotential precursor cell that is capable of undergoing multidirectional differentiation and synthesizing various hormones, mainly glycoproteins.  (+info)

(4/9) Transcranial management of pituitary tumours with suprasellar extension.

A consecutive series of 101 pituitary tumours treated in the 10 year period 1968-78 has been examined, giant lesions being excluded. There were 48 female cases and 53 male, women predominating in the ratio of three to two in the age group 40-50 years and men showing a slight predominance in the age group 50-60 years. Most cases presented with visual deterioration which in 22 cases had been present for between one and two years, and in a further 22 for an even longer period, between two and 10 years. All patients underwent subfrontal craniotomy with mainly radical excision of the tumour followed by radiotherapy. The operative mortality was 0.99%. A system of grading of visual field defect has been described and used to compare preoperatively visual loss with postoperative visual recovery. Fifty-six per cent of cases returned to normal vision over the first two years, and a further 37% showed appreciable improvement in visual fields or acuity or both. Six per cent of cases showed no improvement in visual fields, and one patient died of postoperative deep vein thrombosis and pulmonary embolism. The degree of visual improvement has been correlated with the extent of visual defect, length of visual complaint, and size of the tumour. The importance of central and peripheral visual field analysis is emphasised yet again.  (+info)

(5/9) Gonadotroph adenomas of the human pituitary: sex-related fine-structural dichotomy. A histologic, immunocytochemical, and electron-microscopic study of 30 tumors.

Thirty pituitary tumors, removed from 14 men and 15 women, were diagnosed as gonadotroph adenomas on the basis of their immunocytochemical and/or ultrastructural features. Serum follicle-stimulating hormone (FSH), but not luteinizing hormone (LH), was elevated in 8 men, whereas none of the women had gonadotropin levels, as measured by radioimmunoassay, inappropriately high for their age. Immunoreactive FSH (sometimes also LH) was present in 13 of 15 tumors in men but only 6 of 13 adenomas in women. By electron microscopy, gonadotroph adenomas in men had uncharacteristic features often similar to those of null-cell adenomas with poorly or moderately developed cytoplasmic organelles. In women, all tumors were well differentiated, with a highly distinctive vesicular dilatation of the Golgi complex ("honeycomb Golgi") as a diagnostic marker present in 14 of 15 adenomas. To the author's knowledge, this is the first example of sex-linked dichotomy within a tumor type expressed as the markedly different ultrastructural appearance of cytoplasmic organelles, especially the Golgi apparatus.  (+info)

(6/9) Cytoplasmic filaments of Crooke's hyaline change belong to the cytokeratin class. An immunocytochemical and ultrastructural study.

Crooke's hyaline change was studied by immunocytochemistry using an anti-adrenocorticotropic hormone (ACTH) antiserum and five different antisera against cytokeratins. Crooke's hyaline appears in basophil cells of the adenohypophysis in patients with hypercortisolism, presumably as a part of the negative feedback on corticotropin secretion. Previous studies have identified the hyaline material as a simple protein, apparently unrelated to ACTH, and electron microscopy has revealed a loss of secretory granules and an accumulation of 6-9-nm filaments in the cytoplasm of affected cells. In this study, the secretory granules in adenohypophysial cells exhibiting Crooke's hyaline change were labeled by anti-ACTH antibodies, while the hyaline material was positive for cytokeratin with each of the five antisera used. The results suggest that high levels of glucocorticoids may stimulate elaboration of cytokeratins in basophils while they suppress the production and release of ACTH.  (+info)

(7/9) Silent corticotropic adenomas of the human pituitary gland: a histologic, immunocytologic, and ultrastructural study.

Among 300 surgically removed pituitary adenomas, 17 tumors containing immunoreactive 1-39 adrenocorticotropin (ACTH) and/or 19-39 ACTH, beta-lipotropin, and alpha-endorphin but unassociated with clinical signs of Cushing's disease have been detected. These neoplasms were divided into basophilic adenomas with strong periodic acid-Schiff (PAS) and lead-hematoxylin positivity and chromophobic tumors with moderate or no PAS and lead-hematoxylin positivity. The former were densely granulated tumors with a fine structure strikingly similar to that of functioning corticotropic cell adenomas. The latter were sparsely granulated with varying ultrastructural patterns. The marked morphologic diversity suggests that these adenomas, despite their similar immunocytologic characteristics, represent more than one entity. Clinically, the most common finding was a rapidly progressing visual defect. An unusually high incidence of infarction (5 cases) and recurrence (5 cases) was noted, underlining the importance of correct morphologic diagnosis and careful follow-up.  (+info)

(8/9) Immunohistochemical and immunoelectron-microscopic study of pituitary adenomas associated with Cushing's disease. A report of 13 cases.

Thirteen pituitary adenomas were removed from patients with Cushing's disease by the transphenoidal route. All cases demonstrated a typical histochemical and ultrastructural pattern. Immunocytochemical study by means of the immunoperoxidase technique and light or electron microscopy demonstrated 1-24/1-39 adrenocorticotropic hormone (ACTH) in all cases, lipotropin/melanotropin (beta-LPH/beta-MSH) in 10 cases, beta-endorphin in 8 cases, and an absence of calcitonin in all cases. In addition, in 2 cases tumor tissue contained a few antiprolactin immunoreactive cells. These ACTH, beta-LPH, and beta-endorphin immunoreactivities may reflect either the peptides themselves or their precursors or intermediate products. The authors also suggest a possible intermediate-lobe-like processing of beta-LPH leading to beta-endorphin production, which may act on PRL cells. In addition, no positive arguments for the existence of a common precursor for calcitonin and ACTH could be provided from this study.  (+info)

*  Cushing's disease
Reprinted in Cushing H (April 1969). "The basophil adenomas of the pituitary body". Ann R Coll Surg Engl. 44 (4): 180-1. PMC ... ISBN 978-0-470-67201-3. CS1 maint: Multiple names: authors list (link) Cushing, Harvey (1932). "The basophil adenomas of the ... was that the basophil adenoma Minnie might have harbored underwent partial infarction, leading to symptom regression. The other ... Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome, when excluding Cushing's syndrome from exogenously ...
*  1932 in science
Reprinted in Cushing, Harvey (April 1969). "The basophil adenomas of the pituitary body". Annals of the Royal College of ... ISBN 978-0-89093-547-7. Cushing, Harvey (1932). "The basophil adenomas of the pituitary body and their clinical manifestations ...
*  Harvey Cushing
Reprinted in Cushing, Harvey (April 1969). "The basophil adenomas of the pituitary body and their clinical manifestations ( ... ISBN 1560531649 Cushing, Harvey (1932). "The basophil adenomas of the pituitary body and their clinical manifestations ( ... "The Basophil Adenomas of the Pituitary Body and Their Clinical Manifestations: pituitary Basophilism". Cushing was also awarded ...
*  The Johns Hopkins Medical Journal
First description of what is now known as the Cushing reflex Cushing, Harvey (1932). "The basophil adenomas of the pituitary ...
*  List of MeSH codes (C04)
... adenoma, acidophil MeSH C04.557.470.035.075 --- adenoma, basophil MeSH C04.557.470.035.085 --- adenoma, bile duct MeSH C04.557. ... adenoma, acidophil MeSH C04.557.465.625.650.075 --- adenoma, basophil MeSH C04.557.465.625.650.095 --- adenoma, chromophobe ... adenoma, acidophil MeSH C04.557.580.625.650.075 --- adenoma, basophil MeSH C04.557.580.625.650.095 --- adenoma, chromophobe ... adenoma, liver cell MeSH C04.557.470.035.140 --- adenoma, oxyphilic MeSH C04.557.470.035.155 --- adenoma, pleomorphic MeSH ...
*  International Classification of Diseases for Oncology
M8300/0 Basophil adenoma (C75.1) Mucoid cell adenoma M8300/3 Basophil carcinoma (C75.1) Basophil adenocarcinoma Mucoid cell ... Black adenoma Pigmented adenoma M8373/0 Adrenal cortical adenoma, clear cell (C74.0) M8374/0 Adrenal cortical adenoma, ... Oxyphilic adenoma Oncocytic adenoma Oncocytoma Hurthle cell adenoma(C73.9) Hurthle cell tumor Follicular adenoma, oxyphilic ... NOS Pick tubular adenoma Sertoli cell adenoma Tubular androblastoma, NOS Testicular adenoma M8640/3 Sertoli cell carcinoma (C62 ...
*  Index of oncology articles
... basophil - batimastat - BAY 12-9566 - BAY 43-9006 - BAY 56-3722 - BAY 59-8862 - BB-10901 - BBBD - BBR 2778 - BBR 3464 - BCG - ... tubulovillous adenoma - tumor - tumor antigen vaccine - tumor board review - tumor burden - tumor debulking - tumor ... villous adenoma - villus - vinblastine - vinca alkaloid - vincristine - vindesine - vinorelbine - viral vector - virotherapy - ... adenoma - adenopathy - adenosine triphosphate - adenovirus - adjunct agent - adjunctive therapy - adjuvant therapy - ...
*  Anterior pituitary
A third type of pituitary adenoma secretes excess ACTH, which in turn, causes an excess of cortisol to be secreted and is the ... Nota bene: The term "Basophil" and "Acidophil" is used by some books, whereas others prefer to not use these terms. This is due ... This hypersecretion often results in the formation of a pituitary adenoma (tumour), which are benign apart from a tiny fraction ... Tropic hormones Pituitary adenoma Triple bolus test Posterior pituitary Hypopituitarism Hypothalamic-pituitary-somatic axis ...
Basophil adenoma | definition of basophil adenoma by Medical dictionary  Basophil adenoma | definition of basophil adenoma by Medical dictionary
... basophil adenoma explanation free. What is basophil adenoma? Meaning of basophil adenoma medical term. What does basophil ... Looking for online definition of basophil adenoma in the Medical Dictionary? ... basophil adenoma. Also found in: Dictionary, Thesaurus, Encyclopedia.. Related to basophil adenoma: Pituitary tumor, Pituitary ... basophil adenoma. , basophilic a.. An adenoma of the pituitary gland in which cells stain with basic dyes. The term was ...
more infohttps://medical-dictionary.thefreedictionary.com/basophil+adenoma
Revision history of Basophil adenoma - Biology-Online Dictionary | Biology-Online Dictionary  Revision history of "Basophil adenoma" - Biology-Online Dictionary | Biology-Online Dictionary
Biology-online is a completely free and open Biology dictionary with over 60,000 biology terms. It uses the wiki concept, so that anyone can make a contribution.
more infohttps://www.biology-online.org/dictionary/index.php?title=Basophil_adenoma&action=history
Basophil Adenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials  Basophil Adenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Basophil Adenoma, also known as adenoma, basophil, is related to mixed eosinophil-basophil adenoma and adenoma. An important ... Articles related to Basophil Adenoma:. #. Title. Authors. Year. 1. Cyclical Cushing's disease: two distinct rhythms in a ... Drugs for Basophil Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):. (show all 15) #. Name. Status. ... Diseases related to Basophil Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:. #. Related Disease. ...
more infohttps://www.malacards.org/card/basophil_adenoma
Adenoma, Basophil  Adenoma, Basophil
... - 2 Studies Found. Status. Study Terminated. Study Name: Gamma-Secretase Inhibitor RO4929097 in Treating ...
more infohttp://webhealthnetwork.com/clinicaltrials-search.php?q=Adenoma%2C+Basophil
The basophil adenomas of the pituitary body and their clinical manifestations pituitary basophilism ; In: Bulletin of the Johns...  The basophil adenomas of the pituitary body and their clinical manifestations pituitary basophilism ; In: Bulletin of the Johns...
"The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism)"; In: Bulletin of the ... although the original case series described three instances of pituitary basophilic adenomas." (The life and work of Harvey ...
more infohttps://www.kuenzigbooks.com/pages/books/27472/harvey-cushing/the-basophil-adenomas-of-the-pituitary-body-and-their-clinical-manifestations-pituitary
Acth-producing adenoma | Define Acth-producing adenoma at Dictionary.com  Acth-producing adenoma | Define Acth-producing adenoma at Dictionary.com
Acth-producing adenoma definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. ... Also called basophil adenoma.. The American Heritage® Stedman's Medical Dictionary. Copyright © 2002, 2001, 1995 by Houghton ... acth-producing adenoma in Medicine Expand. ACTH-producing adenoma n. A pituitary tumor causing Cushing's syndrome, composed of ...
more infohttp://www.dictionary.com/browse/acth-producing-adenoma
Weight Gain and Muscular Weakness in a Young Man | SpringerLink  Weight Gain and Muscular Weakness in a Young Man | SpringerLink
Two distinct rhythms in a patient with basophil adenoma. J Clin Endocrinol Metab. 1985;60:328.CrossRefGoogle Scholar ... Pituitary Adenoma Plasma Cortisol Plasma ACTH Dexamethasone Suppression Test Muscular Weakness This is a preview of ... Oldfield EH, Chrousos GP, Schulte MH, et al: Preoperative lateralization of ACTH-secreting pituitary adenomas by bilateral and ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4757-9823-4_19
Cushings disease - Wikipedia  Cushing's disease - Wikipedia
"The basophil adenomas of the pituitary body". Ann R Coll Surg Engl. 44 (4): 180-1. PMC 2387613 . PMID 19310569.. ... Cushing, Harvey (1932). "The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism ... was that the basophil adenoma Minnie might have harbored underwent partial infarction, leading to symptom regression.[3] The ... Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome,[3] when excluding Cushing's syndrome from ...
more infohttps://en.m.wikipedia.org/wiki/Cushing%27s_disease
Harvey Cushing - Wikipedia  Harvey Cushing - Wikipedia
Cushing, Harvey (1932). "The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism ... "The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism)". Ann R Coll Surg Engl. ... "The Basophil Adenomas of the Pituitary Body and Their Clinical Manifestations: pituitary Basophilism".[15] ...
more infohttps://en.wikipedia.org/wiki/Harvey_Williams_Cushing
Historical Trends and Milestones in Hypertension Research | Hypertension  Historical Trends and Milestones in Hypertension Research | Hypertension
The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Bull Johns Hopkins Hosp ... Cushing thought that all of the clinical evidence of this syndrome was caused by a small basophil adenoma of the pituitary. ... The right adrenal containing an adenoma was subsequently removed, and 6 months after surgery her blood pressure was 120/80 mm ...
more infohttp://hyper.ahajournals.org/content/58/4/522.full
Plus it  Plus it
A biopsy performed in six cases showed mucoid (or basophil) adenoma in all. In the four specimens examined ACTH was identified ...
more infohttp://www.bmj.com/content/2/6030/269
Cushing syndrome | definition of Cushing syndrome by Medical dictionary  Cushing syndrome | definition of Cushing syndrome by Medical dictionary
Cushing disease - adrenal hyperplasia (Cushing syndrome) caused by an ACTH-secreting basophil adenoma of the pituitary. Synonym ... adenomas, or cancer Clinical Amenorrhea, hirsutism, HTN, impotence, muscular wasting, skin atrophy, neuropsychiatric ... when associated with an ACTH-producing adenoma, called Cushing disease. Synonym(s): Cushing basophilism. ... when associated with an ACTH-producing adenoma, called Cushing disease. ...
more infohttp://medical-dictionary.thefreedictionary.com/Cushing+syndrome
Indmedica - Current Neurobiology  Indmedica - Current Neurobiology
Cushing H. Basophil adenomas of the pituitary body and their clinical manifestations. Bulletin of the Johns Hopkins Hospital ...
more infohttp://www.indmedica.com/journals.php?journalid=14&issueid=140&articleid=1856&action=article
Cushings Disease: Clinical Manifestations and Diagnostic Evaluation - - American Family Physician  Cushing's Disease: Clinical Manifestations and Diagnostic Evaluation - - American Family Physician
Cranial nerve II may be affected by enlarging pituitary adenomas in Cushing's disease; cranial nerves III, IV and VI may also ... Cushing H. The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Bull Johns ... Although the adenomas of Cushing's disease secrete excessive amounts of ACTH, they generally retain some negative feedback ... Therapy of pituitary adenomas. Endocrinol Metab Clin North Am. 1994;23:925-38. ...
more infohttps://www.aafp.org/afp/2000/0901/p1119.html
11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess | PNAS  11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess | PNAS
1932) The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism) Bull Johns Hopkins ...
more infohttp://www.pnas.org/content/111/24/E2482
Cushings disease - Wikipedia  Cushing's disease - Wikipedia
Reprinted in Cushing H (April 1969). "The basophil adenomas of the pituitary body". Ann R Coll Surg Engl. 44 (4): 180-1. PMC ... ISBN 978-0-470-67201-3. CS1 maint: Multiple names: authors list (link) Cushing, Harvey (1932). "The basophil adenomas of the ... was that the basophil adenoma Minnie might have harbored underwent partial infarction, leading to symptom regression. The other ... Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome, when excluding Cushing's syndrome from exogenously ...
more infohttps://en.wikipedia.org/wiki/Cushing's_disease
1932 in science - Wikipedia  1932 in science - Wikipedia
Reprinted in Cushing, Harvey (April 1969). "The basophil adenomas of the pituitary body". Annals of the Royal College of ... ISBN 978-0-89093-547-7. Cushing, Harvey (1932). "The basophil adenomas of the pituitary body and their clinical manifestations ...
more infohttps://en.wikipedia.org/wiki/1932_in_science
Hormonal aggressiveness according to the expression of cellular markers in corticotroph adenomas | Springer for Research &...  Hormonal aggressiveness according to the expression of cellular markers in corticotroph adenomas | Springer for Research &...
H. Cushing, The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Bull. Johns ... T.W. Noh, H.J. Jeong, M.K. Lee, T.S. Kim, S.H. Kim, E.J. Lee, Predicting recurrence of nonfunctioning pituitary adenomas. J. ... Cushing syndrome ACTH-secreting pituitary adenoma Hormones Biomarkers This is a preview of subscription content, log in to ... Tumor tissues from 28 corticotroph adenomas (female 26, male 2, mean age 39.21 ± 10.39 years) were subject to ...
more infohttps://rd.springer.com/article/10.1007%2Fs12020-018-1815-x
  • Tumor tissues from 28 corticotroph adenomas (female 26, male 2, mean age 39.21 ± 10.39 years) were subject to immunohistochemical study using the following antibodies: pituitary tumor-transforming gene 1 (PTTG1), cyclin D1, p16, p27, brahma related-gene 1 (Brg1), and Ki-67. (springer.com)