Adenoma, Pleomorphic
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
Adenoma, Villous
Pituitary Neoplasms
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Adrenocortical Adenoma
A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.
Adenoma, Chromophobe
Growth Hormone-Secreting Pituitary Adenoma
Colorectal Neoplasms
Colonic Polyps
ACTH-Secreting Pituitary Adenoma
Adenoma, Acidophil
A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)
Prolactinoma
Adenoma, Basophil
Adenomatous Polyposis Coli
Acromegaly
A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
Cushing Syndrome
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
Genes, APC
Hyperparathyroidism
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
Hyperplasia
Neoplasms, Multiple Primary
Pituitary ACTH Hypersecretion
Immunohistochemistry
Carcinoma
Hyperaldosteronism
Sphenoid Bone
An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).
Adrenocorticotropic Hormone
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Pituitary Gland
Hyperparathyroidism, Primary
Precancerous Conditions
Sella Turcica
Pituitary Apoplexy
The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.
Human Growth Hormone
A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.
Colon
Pituitary Hormones
Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.
Adenomatous Polyposis Coli Protein
Urethane
Intestinal Mucosa
Prolactin
A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.
Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. (1/4752)
Overexpression of cell surface glycoproteins of the CD44 family is an early event in the colorectal adenoma-carcinoma sequence. This suggests a link with disruption of APC tumor suppressor protein-mediated regulation of beta-catenin/Tcf-4 signaling, which is crucial in initiating tumorigenesis. To explore this hypothesis, we analyzed CD44 expression in the intestinal mucosa of mice and humans with genetic defects in either APC or Tcf-4, leading to constitutive activation or blockade of the beta-catenin/Tcf-4 pathway, respectively. We show that CD44 expression in the non-neoplastic intestinal mucosa of Apc mutant mice is confined to the crypt epithelium but that CD44 is strongly overexpressed in adenomas as well as in invasive carcinomas. This overexpression includes the standard part of the CD44 (CD44s) as well as variant exons (CD44v). Interestingly, deregulated CD44 expression is already present in aberrant crypt foci with dysplasia (ACFs), the earliest detectable lesions of colorectal neoplasia. Like ACFs of Apc-mutant mice, ACFs of familial adenomatous polyposis (FAP) patients also overexpress CD44. In sharp contrast, Tcf-4 mutant mice show a complete absence of CD44 in the epithelium of the small intestine. This loss of CD44 concurs with loss of stem cell characteristics, shared with adenoma cells. Our results indicate that CD44 expression is part of a genetic program controlled by the beta-catenin/Tcf-4 signaling pathway and suggest a role for CD44 in the generation and turnover of epithelial cells. (+info)MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene-environment interactions in colorectal tumorigenesis. (2/4752)
Our studies on interactions of a folate-metabolizing gene polymorphism and dietary intake in colorectal tumorigenesis demonstrate the potential importance of studying interactions between genotype and environmental exposure in relation to cancer risk. We observed an inverse association of a polymorphism (667C --> T, ala --> val) in the methylenetetrahydrofolate reductase (MTHFR) gene with colorectal cancer but not with colorectal adenomas. The inverse association of methionine and adverse association of alcohol with colorectal cancer were stronger among val/val individuals. These interactions were not present in studies of colorectal adenomas. Our studies illustrate that studying gene-environment interactions in relation to cancer can be of importance in clarifying cancer etiology as well as pointing to preventive dietary modifications. (+info)Expression of relaxin-like factor is down-regulated in human testicular Leydig cell neoplasia. (3/4752)
In addition to their role in steroidogenesis in the male, testicular Leydig cells constitutively express large amounts of the peptide relaxin-like factor (RLF), also known as Ley-IL. The Leydig cell-derived RLF belongs to the insulin-like superfamily, which also includes relaxin, insulin and the insulin-like growth factors, and within the testis is a specific marker of Leydig cells. Little information is available either on the regulation of gene expression or on the function of this Leydig cell-derived peptide. In the present study we have investigated the expression pattern of human RLF in patients with rare Leydig cell hyperplasia and adenoma. The expression of both mRNA and protein appear to be decreased in hyperplastic Leydig cells, whereas in the Leydig cell adenomas studied, large central areas of the adenoma were devoid of RLF mRNA and protein. Only Leydig cells located at the periphery of the adenoma displayed expression of RLF, with full agreement between in-situ hybridization and immunohistochemistry. It thus appears that the expression of the RLF gene and its products are down-regulated in Leydig cell hyperplasia and adenoma, consistent with a concomitant dedifferentiation of these cells. (+info)Effect of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis and aberrant crypt foci. (4/4752)
We have previously reported that the retinoids, 4-(hydroxyphenyl)retinamide (4-HPR) and 9-cis-retinoic acid (RA) prevented azoxymethane (AOM)-induced colon tumors and along with 2-(carboxyphenyl)retinamide (2-CPR) prevented aberrant crypt foci (ACF). In this study, we evaluated the effect of 2-CPR on AOM-induced colon tumors and the effect of the three retinoids on apoptosis and cell proliferation. Male F344 rats were administrated 15 mg/kg AOM at weeks 7 and 8 of age. 2-CPR (315 mg/kg) was administered in the diet starting either 1 week before or at week 12 after the first dose of AOM. The rats continued to receive the 2-CPR until killed at week 46. Unlike the demonstrated prevention of colon cancer by the other two retinoids, both dosing schedules of 2-CPR resulted in an approximate doubling of the yield of colon tumors. In adenomas, 2-CPR, 4-HPR and 9-cis-RA were equally effective in reducing mitotic activity, while only 4-HPR and 9-cis-RA but not 2-CPR enhanced apoptosis. When administered for only the 6 days prior to killing 4-HPR but not 2-CPR decreased the Mitotic Index and increased the Apoptotic Index in adenomas. In non-involved crypts, chronic exposure to 4-HPR and 9-cis-RA in contrast to 2-CPR reduced the Mitotic Index and enhanced the Apoptotic Index. In concurrence with our previous study, both 2-CPR and 4-HPR were very potent in preventing ACF when administered in the diet starting 1 week before the first dose of AOM and continuing for the 5 weeks of the study. Hence, unlike the other two retinoids, 2-CPR, although very potent in preventing ACF, enhanced rather than prevented AOM-induced colon cancer. Furthermore, our results suggest that the effect of 2-CPR on tumor yield is different from 4-HPR and 9-cis-RA because, unlike them, it does not enhance apoptosis. (+info)Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell. (5/4752)
Human methylguanine-DNA methyltransferase (MGMT) transgenic mice expressing high levels of O6-alkylguanine-DNA alkyltransferase (AGT) in lung were crossbred to A/J mice that are susceptible to pulmonary adenoma to study the impact of O6-methylguanine (O6mG)-DNA adduct repair on NNK-induced lung tumorigenesis. Expression of the chimeric human MGMT transgene in lung was identified by northern and western blot analysis, immunohistochemistry assay and enzymatic assay. AGT activity was 17.6 +/- 3.2 versus 1.2 +/- 0.4 fmol/microg DNA in lung of MGMT transgenic mice compared with non-transgenic mice. Immunohistochemical staining with anti-human AGT antibody showed that human AGT was expressed throughout the lung. However, some epithelial cells of bronchi and alveoli did not stain for human AGT, suggesting that the human MGMT transgene expression was heterogeneous. After 100 mg/kg NNK i.p. injection in MGMT transgenic mice, lung AGT activity remained much higher and levels of lung O6mG-DNA adducts in MGMT transgenic mice were lower than those of non-transgenic mice. In the tumorigenesis study, mice received 100 mg/kg NNK at 6 weeks of age and were killed 44 weeks later. Ten of 17 MGMT transgenic mice compared with 16 of 17 non-transgenic mice had lung tumors, P < 0.05. MGMT transgenic mice had lower multiplicity and smaller sized lung tumors than non-transgenic mice. Moreover, a reduction in the frequency of K-ras mutations in lung tumors was found in MGMT transgenic mice (6.7 versus 50% in non-transgenic mice). These results indicate that high levels of AGT expressed in mouse lung reduce lung tissue susceptibility to NNK-induced tumorigenesis due to increased repair capacity for O6mG, subsequently, decreased mutational activation of K-ras oncogene. Heterogeneity in the level of AGT expressed in different lung cell populations or other forms of carcinogenic DNA damage caused by NNK may explain the residual incidence of lung tumors in MGMT transgenic mice. (+info)Possible carcinogenic effects of X-rays in a transgenerational study with CBA mice. (6/4752)
A lifetime experiment using 4279 CBA/J mice was carried out to investigate whether the pre-conceptual exposure of sperm cells to X-ray radiation or urethane would result in an increased cancer risk in the untreated progeny, and/or increased susceptibility to cancer following exposure to a promoting agent. The study consisted of four main groups, namely a control group (saline), a urethane group (1 mg/g body wt) and two X-ray radiation groups (1 Gy, 2 Gy). At 1, 3 and 9 weeks after treatment, the males of these four parental groups were mated with untreated virgin females. The offspring of each parental group was divided into two subgroups: one received s.c. urethane (0.1 mg/g body wt once) as a promoter, the other saline, at the age of 6 weeks. All animals were evaluated for the occurrence of tumours. K-ras oncogene and p53 tumour suppressor gene mutations were investigated in frozen lung tumour samples. The female offspring of male parents exposed to X-rays 1 week before their mating showed a trend towards a higher tumour incidence of the haematopoietic system than the F1 controls. In addition, a higher percentage of bronchioloalveolar adenocarcinomas in male offspring born to irradiated paternals mated 1 week after X-ray treatment points to a plausible increased sensitivity of post-meiotic germ cell stages towards transgenerational carcinogenic effects. On the other hand, no increased tumour incidence and malignancy were observed in the offspring born to irradiated paternals mated 3 and 9 weeks after X-ray treatment. Paternal urethane treatment 1, 3 and 9 weeks prior to conception did not result in significantly altered incidence or malignancy of tumours of the lung, liver and haematopoietic tissue in the offspring. K-ras mutations increased during tumour progression from bronchioloalveolar hyperplasia to adenoma. Codon 61 K-ras mutations were more frequent in lung tumours of urethane-promoted progeny from irradiated parents than from control parents. P53 mutations were absent from these lung alterations. (+info)Epithelial thyroid tumors in cows. (7/4752)
From 1964 to 1973, 370 tumors were collected from cows of unknown age. Ten (2.7%) of these were primary thyroid tumors. Three were malignant. The benign tumors were solitary encapsulated adenomas in the parenchyma with more or less defined trabeculae, tubular, and microfollicular pattern. One of the malignant tumors was a cystic papillary adenocarcinoma, and two were small cell carcinomas consisting of small, sometimes binuclear, pleomorphic cells. (+info)The elevated serum alkaline phosphatase--the chase that led to two endocrinopathies and one possible unifying diagnosis. (8/4752)
A 39-year-old Chinese man with hypertension being evaluated for elevated serum alkaline phosphatase (SAP) levels was found to have an incidental right adrenal mass. The radiological features were characteristic of a large adrenal myelolipoma. This mass was resected and the diagnosis confirmed pathologically. His blood pressure normalised after removal of the myelolipoma, suggesting that the frequently observed association between myelolipomas and hypertension may not be entirely coincidental. Persistent elevation of the SAP levels and the discovery of hypercalcaemia after surgery led to further investigations which confirmed primary hyperparathyroidism due to a parathyroid adenoma. The patient's serum biochemistry normalised after removal of the adenoma. The association of adrenal myelolipoma with primary hyperparathyroidism has been reported in the literature only once previously. Although unconfirmed by genetic studies this association may possibly represent an unusual variation of the multiple endocrine neoplasia type 1 syndrome. (+info)
Dietary Marine n-3 Fatty Acids in Relation to Risk of Distal Colorectal Adenoma in Women | Cancer Epidemiology, Biomarkers &...
Pituitary adenoma - Wikipedia
Colorectal Adenoma Stem-like Cell Populations: Associations with Adenoma Characteristics and Metachronous Colorectal Neoplasia ...
Health Sciences Research Commons - GW Research Days 2016 - Present: Race Does Not Affect the Prevalence of Sporadic Adenomas in...
Both Transforming Growth Factor-β and Substrate Release Are Inducers of Apoptosis in a Human Colon Adenoma Cell Line<...
Serrated adenoma and APC gene mutation | Journal of Medical Genetics
Evaluation of Clinico-Radio-Pathological Features of Tubular Adenoma of Breast: a Study of Ten Cases with Histopathological...
대장 선종-암화 단계별 과정과 채소 및 과일 섭취와의 관련성
Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European...
Prestren | Pituitary adenoma - Prestren
Thyroid adenoma
Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled,...
Increased risk of adenomas in individuals with a family history of colorectal cancer: results of a meta-analysis<...
Alveolar adenoma of the lung: unusual diagnosis of a lesion positive on PET scan. A case report | Journal of Cardiothoracic...
PLOS ONE: Down-Regulation of CDH1 Is Associated with Expression of SNAI1 in Colorectal Adenomas
The prevalence of colorectal adenomas in asymptomatic Korean men and women
Estimation of colorectal adenoma recurrence with dependent censoring<...
Long-term use of multivitamins and risk of colorectal adenoma in women
Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their...
Increased risk of colorectal adenomas in Italian subjects carrying the p53 PIN3 A2-Pro72 haplotype<...
Plus it
Frequent nuclear accumulation of β-catenin in pituitary adenoma<...
Loss of expression and promoter methylation of SLIT2 are associated with sessile serrated adenoma formation. - Nuffield...
Prostate adenoma. Treatment in Tashkent.
Plus it
No Association between Circulating Levels and Genetic Variants of IL-6 and TNF-α and Colon Adenoma - Semantic Scholar
Risk stratification of individuals with low-risk colorectal adenomas using clinical characteristics: A pooled analysis<...
CT and ultrasound features of metanephric adenoma in adults with pathologic correlation<...
FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans : Carcinogenesis...
Expression of vascular endothelial growth factor and its receptors in human anterior pituitary adenomas
GastroHep News Story
Study of Prevalence of Colorectal Adenoma in 30- to 49-year-old Subjects With a Family History of Colorectal Cancer - Full Text...
Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas<...
GastroHep News Story
Endocrinology, Luloot Academy | Tag Archives: Adenohypophyseal Hormones DefinitionAdenohypophyseal Hormones Definition Archives...
Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal...
Vse o adenoma prostate: vzroki, simptomi, zdravljenje, prognoze - Simptomi 2020
Zdravljenje adenoma prostatitisa z pijavkami
Adenoma - secreting
B Vitamins Dont Cut Colorectal Adenoma Risk | Medpage Today
S0820, Adenoma and Second Primary Prevention Trial - Full Text View - ClinicalTrials.gov
Novel patterns of gene expression in pituitary adenomas identified by complementary deoxyribonucleic acid microarrays and...
What is a Benign Adrenal Adenoma? | Health Nucleus
Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence
Spolne težave po odstranitvi adenoma prostate
Adenoma prostate: metode in metode zdravljenja brez kirurškega posega - Zdravljenje July
Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas<...
Statins Do Not Protect Patients Against Risk of Colorectal Adenoma | AACR News
Dopamine 2 and somatostatin 1-5 receptors coexpression in clinically non-functioning pituitary adenomas. - Semantic Scholar
Pain characteristics in patients with Cushings disease compared to patients with non-functioning pituitary adenomas
RNF43 Is an Early and Specific Mutated Gene in the Serrated Pathway, With Increased Frequency in Traditional Serrated Adenoma...
COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics<...
Axis-specific analysis and predictors of endocrine recovery and deficits for non-functioning pituitary adenomas undergoing...
A mutation and expression analysis of the oncogene BRAF in pituitary adenomas | Archivio Istituzionale della Ricerca
Immunohistochemical Studies of Chromogranins (A and C) in Pituitary Adenomas<...
Methionine Synthase D919G Polymorphism, Folate Metabolism, and Colorectal Adenoma Risk<...
Frontiers | Single-Cell Phenotypic Characterization of Human Pituitary GHomas and Non-Functioning Adenomas Based on Hormone...
Arterial Spin-Labeled Perfusion Imaging Reflects Vascular Density in Nonfunctioning Pituitary Macroadenomas | American Journal...
Whole-exome sequencing studies of nonhereditary (sporadic) parathyroid adenomas. - Immunology
Epithelial Splicing Regulator Protein 1 and Alternative Splicing in Somatotroph Adenomas
Clinical manifestations and diagnosis of gonadotroph and other clinically nonfunctioning pituitary adenomas
Acidophile pituitary adenoma | definition of acidophile pituitary adenoma by Medical dictionary
Adenoma of the ampulla of Vater: putative precancerous lesion. | Gut
Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum<...
Light bodies in human pituitary adenomas - Danish National Research Database-Den Danske Forskningsdatabase
A prospective randomised study on narrow-band imaging versus conventional colonoscopy for adenoma detection: does narrow-band...
Heterogeneous genetic background of the association of pheochromocytoma/paraganglioma and pituitary adenoma: results from a...
Regression of a Non-Functioning Pituitary Macroadenoma on the CDK4/6 Inhibitor Palbociclib - cns.org
C-reactive protein and colorectal adenomas: Self Defense Forces Health Study<...
ORBi: Browsing ORBi
Pituitary adenoma 5, multiple types
Pituitary adenoma 3, multiple types
ORBi: Browsing ORBi
Growth hormone-producing adenoma | Define Growth hormone-producing adenoma at Dictionary.com
The expression of E-cadherin in somatotroph pituitary adenomas is related to tumor size, invasiveness, and somatostatin analog...
Usefulness of markers of cell proliferation in the management of pituitary adenomas | Clinical Science
Most recent papers with the keyword Diverticular associated colitis | Read by QxMD
Best Parathyroid Adenoma Doctor in Thane, Parathyroid Adenoma Doctors | Credihealth
KRAS mutations in traditional serrated adenomas from Korea herald an aggressive phenotype
Non-functioning pituitary adenomas: endocrinological results after.... EANS Academy. Zoia C. Sep 25 2019; 275447
Dietary fiber intake and risk of colorectal cancer and incident and recurrent adenoma in the PLCO Cancer Screening Trial - USGE...
Pituitary Hormone INTRODUCTION Pituitary adenoma (PA) - Polo-Like Kinases and Aurora Kinases in Cancer Therapy
Mixed-cell adenoma | definition of mixed-cell adenoma by Medical dictionary
Adenoma da próstata e yoga
Index of oral health and dental articles
Canalicular adenoma • Canine tooth • Cantilever mechanics • Carbon dioxide laser • Caries vaccine • Carnassial • Case School of ... Pleomorphic adenoma • Pleurodont • Plica fimbriata • Polk E. Akers • Polymorphous low-grade adenocarcinoma • Polynoxylin • ...
Hyperparathyroidism
... or parathyroid adenoma). It is used by surgeons to locate ectopic parathyroid adenomas, most commonly found in the anterior ... Parathyroid adenomas have been linked with DDT although a causal link has not yet been established. Normal parathyroid glands ... "Parathyroid Adenoma". BrighamRAD Teaching Case Database. Archived from the original on 2011-07-16. Carroll MF, Schade DS (May ... Parathyroid adenomas are very rarely detectable on clinical examination. Surgical removal of a parathyroid tumor eliminates the ...
List of OMIM disorder codes
TCF4 Pituitary adenoma, ACTH-secreting; 219090; AIP Pituitary adenoma, growth hormone-secreting; 102200; AIP Pituitary adenoma ... PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, salivary gland pleomorphic; 181030; PLAG1 Adenomatous polyposis ... EIF2B4 Leydig cell adenoma, somatic, with precocious puberty; 176410; LHCGR Leydig cell hypoplasia with hypergonadotropic ... SCN4A Parathyroid adenoma with cystic changes; 145001; HRPT2 Parathyroid carcinoma; 608266; HRPT2 Parietal foramina 1; 168500; ...
Hürthle cell neoplasm
This adenoma is extremely rare; when it occurs, it usually occurs in women. Often the adenoma is harmless but is removed after ... There are three main treatments for Hürthle cell adenomas. Once the adenoma is detected most often the nodules removed to ... 1998), "Unilateral lobectomy for Hürthle cell adenoma", Am Surg, 64 (8): 729-732, PMID 9697901. "Hurthle Cell Adenoma". www. ... "Appearance of Hürthle cell carcinoma soon after surgical extirpation of Hürthle cell adenoma and follicular adenoma of the ...
Colorectal polyp
... villous adenoma): Tubular Adenoma: 5% risk of cancer Tubulovillous adenoma: 20% risk of cancer Villous adenoma: 40% risk of ... Neoplastic polyps of the bowel are often benign hence called adenomas. An adenoma is a tumor of glandular tissue, that has not ... villous adenoma which are long finger like projections on the surface, and tubulovillous adenoma which has features of both.: ... villous adenomas are no more likely than tubular or tubulovillous adenomas to become cancerous if their sizes are all the same ...
Sestamibi parathyroid scan
... such that oxyphil cell parathyroid adenomas have a very high avidity for sestamibi, while chief cell parathyroid adenomas have ... A sestamibi parathyroid scan is a procedure in nuclear medicine which is performed to localize parathyroid adenoma, which ... Adequate localization of parathyroid adenoma allows the surgeon to use a minimally invasive surgical approach. Tc99m-sestamibi ... Approximately 60 percent of parathyroid adenomas may be imaged by sestamibi scanning. The natural distribution of causation for ...
Parathyroid neoplasm
Types include: Parathyroid adenoma Parathyroid carcinoma[citation needed] Sekine O, Hozumi Y, Takemoto N, Kiyozaki H, Yamada S ... Konishi F (March 2004). "Parathyroid adenoma without hyperparathyroidism". Japanese Journal of Clinical Oncology. 34 (3): 155-8 ...
Hypercalcaemia
ISBN 978-0-07-147247-0. Sekine O, Hozumi Y, Takemoto N, Kiyozaki H, Yamada S, Konishi F (March 2004). "Parathyroid adenoma ... Primary hyperparathyroidism Solitary parathyroid adenoma Primary parathyroid hyperplasia Parathyroid carcinoma Multiple ...
Liver tumor
Hepatocellular adenomas (also called hepatocellular adenoma) are rare benign liver tumors made up of hepatocytes, with ... Liver cell adenomatosis differs from hepatic adenomas by its definition of more than 10 hepatic adenomas that are in both liver ... The best way to biopsy suspected hepatic adenoma is via open or laparoscopic excisional biopsy. Because hepatocellular adenomas ... the adenoma is recommended to be surgically removed. Like most liver tumors, the anatomy and location of the adenoma determines ...
Hounsfield scale
medscape >Adrenal Adenoma Imaging. Author: Perry J Horwich. Chief Editor: Eugene C Lin. Updated: Apr 21, 2011 Feeman, Timothy G ... tumor with a radiodensity of less than 10 HU is rather fatty in composition and almost certainly a benign adrenal adenoma. Cone ...
Caretaker gene
Bosman, F. T. (1999). "The hamartoma-adenoma-carcinoma sequence". The Journal of Pathology. 188 (1): 1-2. doi:10.1002/(SICI) ...
Histopathology of colorectal adenocarcinoma
Colorectal adenocarcinoma is distinguished from a colorectal adenoma (mainly tubular and ⁄or villous adenomas) mainly by ... Precancer - Colorectal villous adenoma A lesion at least "high grade intramucosal neoplasia" (high grade dysplasia) has: Severe ... "Colorectal Adenoma Containing Invasive Adenocarcinoma". Stanford University School of Medicine. Finlay A Macrae. "Overview of ... Cancer - Histopathologic image of colonic carcinoid Precancer - Tubular adenoma (left of image), a type of colonic polyp and a ...
Hyperandrogenism
In rare cases, however, some adrenal adenomas may become activated. When activated, the adenoma begins to produce hormones in ... Adrenal adenomas are benign tumors of the adrenal gland. In most cases, the tumors display no symptoms and require no treatment ... "Adenoma of the Adrenal Gland". Genetic and Rare Diseases Information Center(GARD) - an NCATS Program. U.S National Library of ... Most people with the disorder have a single adenoma. This form of the syndrome, known as Cushing's disease Forbis P (2005). ...
Henry Pickerill
Pickerill, H P. (1951). "Sebaceoma Nasi, Adenoma Sebaceum (Rhinophyma)." The New Zealand Medical Journal50 (279): 502-3. ...
Parathyroid chief cell
... known respectively as a single adenoma or double adenoma. Typically, no disease is linked to the cause. A primary adenoma can ... A parathyroid adenoma is the most common cause of hyperparathyroidism. They are more commonly found in women than in men. In ... The hyperplasia is seen as an enlargement of all four of the parathyroid glands, as opposed to a parathyroid adenoma is viewed ... "Parathyroid adenoma: MedlinePlus Medical Encyclopedia". www.nlm.nih.gov. Retrieved 2015-11-18. Cope, Oliver; Keynes, W. Milo; ...
THADA (gene)
"Entrez Gene: Thyroid adenoma associated". Retrieved 2013-06-10. v t e (Genes on human chromosome 2, All stub articles, Human ... Thyroid adenoma associated is a protein in humans that is encoded by the THADA gene. GRCh38: Ensembl release 89: ...
Hypophysectomy
Sometimes it is used to treat Cushing's syndrome due to pituitary adenoma or Simmond's disease It is also applied in ... List of surgeries by type Jaffe, CA (2006). "Clinically non-functioning pituitary adenoma". Pituitary. 9 (4): 317-21. doi: ...
Computed tomography of the thyroid
Parathyroid adenoma (PA) is the most common cause of primary hyperparathyroidism. Ectopic parathyroid adenoma is rare. The ... An adenoma may undergo cystic degeneration. It is important to note that papillary carcinoma may mimic a benign-looking cyst. ... Intra-thyroid parathyroid adenomas mimic thyroid nodules in CT scans and may even show uptake on a thyroid iodine scan. ... Elevated FNA-iPTH measurement, as compared to serum iPTH, is considered positive and diagnostic of parathyroid adenoma. Thyroid ...
Catenin
Summary: Associated Cancers: colorectal and ovarian cancer; pilomatrixoma; medulloblastoma; pleomorphic adenomas; malignant ... pleomorphic adenomas, and malignant mesothelioma. While less is known about the exact mechanism of α-catenin, its presence in ... "The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the β-catenin signaling pathway". ...
John James Pringle
... "adenoma sebaceum" from Félix Balzer's phrase "adénomes sébacés". The papules were in fact neither adenoma nor derived from ... President of the dermatology section of the Royal Society of Medicine Pringle, JJ (1890). "A case of congenital adenoma ... JJ Pringle is primarily remembered for the eponym: Pringle's Adenoma Sebaceum. Now known as facial angiofibroma, this papular ... physicians would recognize that the combination of adenoma sebaceum, epilepsy and learning disability was diagnostic for ...
Hürthle cell
A Hürthle cell adenoma or a minimally invasive tumor can be treated by a thyroid lobectomy, although some surgeons will perform ... Hürthle cell adenomas are most likely diagnosed much more frequently than Hürthle cell carcinomas. The female to male ratio for ... Adenoma Oncocytoma Oxyphil cell "Endocrine Pathology". Retrieved 2009-05-07. Grani, Giorgio; Lamartina, Livia; Durante, Cosimo ... As expected, patients with carcinoma usually present larger tumors than patients with adenoma. Rarely, the cancer can spread to ...
HNF1A
Moreover, significantly lower levels of HNF-1α in pancreatic tumors and hepatocellular adenomas than in normal adjacent tissues ... as well as hepatocellular adenoma. HNF-1 protein is present in clear cell carcinoma of ovary. In humans, mutations in HNF1A ... "Bi-allelic inactivation of TCF1 in hepatic adenomas". Nature Genetics. 32 (2): 312-5. doi:10.1038/ng1001. PMID 12355088. S2CID ... "Genotype phenotype classification of hepatocellular adenoma". World Journal of Gastroenterology. 13 (19): 2649-54. doi:10.3748/ ...
Timeline of tuberous sclerosis
... adenoma of the sebaceous glands of the face and scalp). The term has since proved to be incorrect as they are neither adenoma ... Pringle's adenoma sebaceum would become a common eponym for the facial rash. 1901 Italian physician GB Pellizzi studied the ... 1885 French dermatologists François Henri Hallopeau and Émile Leredde published a case of adenoma sebaceum that was of a hard ... Vogt's triad of epilepsy, idiocy, and adenoma sebaceum held for 60 years until research by Manuel Gómez discovered that fewer ...
Adam Rainer
A benign pituitary adenoma was found, which was responsible for the enormous growth. Dr. Oskar Hirsch removed the adenoma. ...
Rectal discharge
Adenoma is the most common colorectal polyp. Adenomas are not malignant, but rarely adenocarcinoma can develop from them. Large ... villous adenoma, poor anal hygiene[citation needed] Rare causes include: sexually transmitted diseases (e.g. syphilis, rectal ... adenomas can cause rectal bleeding, mucus discharge, tenesmus, and a sensation of urgency. Mucus production may be so great ...
Sialoblastoma
It is important that other tumors such as pleomorphic adenoma, basal cell adenoma, adenoid cystic carcinoma, and teratoma be ... It has previously been referred to as congenital basal cell adenoma, embryoma, or basaloid adenocarcinoma. It is an extremely ... Seifert, G.; Donath, K. (1997). "The congenital basal cell adenoma of salivary glands. Contribution to the differential ... "congenital pleomorphic adenoma"). A clinicopathologic, immunohistochemical and ultrastructural study of nine cases". Am J Surg ...
Ravinder Goswami
Chandan Jyoti Das, Ashu Seith, Shivanand Gamanagatti, Ravinder Goswami (2006). "Ectopic Pituitary Adenoma with an Empty Sella ...
PLAG1
"PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using ... "Entrez Gene: PLAG1 pleiomorphic adenoma gene 1". Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML (May 2002 ... Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is ... Voz ML, Agten NS, Van de Ven WJ, Kas K (2000). "PLAG1, the main translocation target in pleomorphic adenoma of the salivary ...
Pseudohyperaldosteronism
Adrenal tumor subtypes include adrenal adenomas that produce 11-deoxycorticosterone (DOC) leading to increased ... "A case of deoxycorticosterone-producing adrenal adenoma". Endocrine Journal. 42 (5): 637-642. doi:10.1507/endocrj.42.637. ISSN ...
Visual pathway lesions
Pituitary adenoma compression may cause LGN degeneration. Lesions affecting the anterior or lateral choroidal arteries may ... "Pituitary Adenoma Causing Compression of the Optic Chiasm". eyerounds.org. "Craniopharyngioma". NORD (National Organization for ... Compression of the optic chiasm is associated with pituitary adenoma, Craniopharyngioma, Meningioma etc. A lesion involving ... "Measuring degeneration of the lateral geniculate nuclei from pituitary adenoma compression detected by 7T ultra-high field MRI ...
Hepatocellular Adenoma in Men
... hepatocellular adenoma does occur in men. This study aimed to correlate immunological, histopathological, and molecular ... B-catenin activated adenoma with CTNNB1 exon 3 mutation (Bex3HCA, 8%), B-catenin activated adenoma with CTNNB1 exon 7/8 ... B-catenin activated inflammatory adenoma with CTNNB1 exon 7/8 mutation (Bex7,8IHCA, 5%) and sonic hedgehog adenoma (sh-HCA, 4 ... Hepatocellular adenoma (HCA) is a benign liver tumour, occurring predominantly in females, but sporadically in males. The ...
Aldosterone-producing adenoma: MedlinePlus Genetics
An aldosterone-producing adenoma is a noncancerous (benign) tumor that develops in an adrenal gland, which is a small hormone- ... Aldosterone-producing adenomas are caused by mutations in one of several genes. The most commonly mutated gene is KCNJ5, ... An aldosterone-producing adenoma is a noncancerous (benign) tumor that develops in an adrenal gland, which is a small hormone- ... Aldosterone-producing adenomas are generally not inherited but arise from a mutation in the bodys cells that occurs after ...
Sebaceous Adenoma Differential Diagnoses
encoded search term (Sebaceous Adenoma) and Sebaceous Adenoma What to Read Next on Medscape ... Sebaceous Adenoma Differential Diagnoses. Updated: Aug 05, 2019 * Author: Nicole Ufkes; Chief Editor: William D James, MD more ... Sebaceous cell adenoma. Rare intra-oral occurrence of a tumour which is a frequent marker of Torres syndrome. Pathology. 1987 ... Sia PI, Rajak S, James C, Huilgol S, Selva D. Sebaceous adenomas in the absence of Muir-Torre syndrome. Can J Ophthalmol. 2016 ...
Adenoma - Wikipedia
Hepatic adenomas are a rare benign tumour of the liver, which may present with hepatomegaly or other symptoms. Breast adenomas ... An adenoma is a benign tumor of epithelial tissue with glandular origin, glandular characteristics, or both. Adenomas can grow ... Over time adenomas may transform to become malignant, at which point they are called adenocarcinomas. Most adenomas do not ... Bronchial adenomas are adenomas in the bronchi. They may cause carcinoid syndrome, a type of paraneoplastic syndrome. A ...
Pituitary Adenoma
Growth Hormone-Secreting Pituitary Adenoma, ACTH-Secreting Pituitary Adenoma, Thyrotroph Adenoma, TSH-Secreting Adenoma, ... Pituitary Adenoma, Pituitary Neoplasm, Functionless Pituitary Adenoma, Non-Functioning Pituitary Adenoma, Secretory Pituitary ... Adenoma, Pituitary Macroadenoma, Pituitary Microadenoma, Pituitary Incidentaloma, Prolactinoma, Prolactin-Secreting Pituitary ... Corticotroph adenoma, ACTH-secreting pituitary adenoma, Corticotroph adenoma (disorder), ACTH secreting adenoma, adenoma, ACTH ...
Pituitary Adenoma Treatment Information | Moffitt
... including pituitary adenomas. Learn about symptoms and treatment options here. ... Pituitary adenoma causes The causes of pituitary adenomas are still unclear. Tumors in general typically form as a result of ... functioning pituitary adenomas. Pituitary adenomas, which are significantly more common than malignant (cancerous) tumors, can ... Signs of a pituitary adenoma. The signs of a pituitary adenoma can vary considerably based on the tumors size, precise ...
Understanding Your Pathology Report: Colon Polyps (Sessile or Traditional Serrated Adenomas)
What are tubular adenomas, tubulovillous adenomas, and villous adenomas?. Adenomas can have several different growth patterns ... Many adenomas have a mixture of both growth patterns, and are called tubulovillous adenomas. Most adenomas that are small (less ... Larger adenomas may have a villous growth pattern. Larger adenomas more often have cancers developing in them. Adenomas with a ... What does it mean if I have an adenoma (adenomatous polyp), such as a sessile serrated adenoma or traditional serrated adenoma? ...
New study demonstrates link between smoking and flat adenomas
Flat adenomas are more difficult to detect and have more aggressive pathology than the typical raised type of polyp detected ... smoking was found to have a strong association with the presence of flat adenomas (precancerous polyps) in the colon and may ... Not only was smoking associated with all flat adenomas, it was also a risk factor for those patients who only had flat adenomas ... Flat nonpolypoid adenomas are considered to be more aggressive than polypoid (raised) adenomas. Therefore, it is recommended ...
Cushing syndrome: ACTH-secreting pituitary adenomas Videos - Mayo Clinic
Middle Ear Adenoma
The genome-wide mutational landscape of pituitary adenomas | Cell Research
CircVPS13C promotes pituitary adenoma growth by decreasing the stability of IFITM1 mRNA via interacting with RRBP1 *Weiyu Zhang ... Pituitary adenomas (PAs) are one of the most common intracranial tumors, which can result in significant morbidity and can ... Celastrol Induces Apoptosis and Autophagy via the AKT/mTOR Signaling Pathway in the Pituitary ACTH-secreting Adenoma Cells *Zhi ... The genome-wide mutational landscape of pituitary adenomas. *Zhi-Jian Song1 na1, ...
Image: Tubulovillous Adenoma - Merck Manuals Consumer Version
Pathology Outlines - Pleomorphic adenoma-eyelid
Perianal Adenoma in Dogs | Symptoms, Treatment & Prevention
A perianal adenoma is a common tumor that arises from the sebaceous glands surrounding the anus. Learn about symptoms, high- ... A perianal adenoma (also known as circumanal adenoma and hepatoid adenoma) is a common tumor that arises from the sebaceous ... some perianal adenomas can be classified into an intermediate category called invasive perianal adenoma. These tumors can act ... Perianal adenomas appear as slow-growing, non-painful masses around the anus. They usually emerge in the hairless area of the ...
Gastric carcinoid tumour and parathyroid adenoma. | Gut
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Water-clear cell adenoma associated with primary hyperparathyroidism: report of a case | SpringerLink
We report a case of water-clear cell adenoma associated with primary hyperparathyroidism. A 59-year-old woman with a history of ... Water-clear cell adenoma associated with primary hyperparathyroidism: report of a case. *Keigo Murakami. 1, ... Liang Y, Mojica W, Chen F. Water-clear cell adenoma of parathyroid gland: a case report and literature review. N Am J Med Sci. ... Water-clear cell adenoma of the parathyroid. A case report with immunohistochemistry and electron microscopy. Arch Pathol Lab ...
Effects of metformin on cell growth and AMPK activity in pituitary adenoma cell cultures, focusing on the interaction with...
... as a target for drug therapy of GH-secreting pituitary adenomas. Aim of this study was to investigate the direct effects of ... metformin, which causes AMPK activation in different cell types, on rat pituitary adenoma cell gr … ... Effects of metformin on cell growth and AMPK activity in pituitary adenoma cell cultures, focusing on the interaction with ... on rat pituitary adenoma cell growth and on related cell signalling pathways. Our results suggest that metformin can exert a ...
British Library EThOS: Sophorolipid-mediated inhibition of adenoma development in familial adenomatous polyposis syndrome
Sebaceous adenoma | Multimedia Encyclopedia | Health Information | St. Luke's Hospital
Superadded aspergillosis on carcinoid bronchial adenoma leading to delayed diagnosis. | Postgraduate Medical Journal
Notch as a Possible Cell Differentiation Factor in Pleomorphic Adenomas
Keywords: Notch1, pleomorphic adenoma, cell differentiation, immunohistochemistry Introduction. Pleomorphic adenoma (PA) is the ... 1. Eveson JW, Kusafuka K, Stenman G, Nagano T. Pleomorphic adenoma. In: (ed.) Barnes L, Eveson JW, Reichart P, Sidransky D. ... Ihrler S, Schwarz S, Zengel P, Guntinas-Lichius O, Kirchner T, Weiler C. Pleomorphic adenoma: Pitfalls and clinicopathological ... Notch as a Possible Cell Differentiation Factor in Pleomorphic Adenomas Keisuke Takamine1, Yukiko Ueda1, Keisuke Nakano1, 2, ...
Sequential MR enhancement pattern in normal pituitary gland and in pituitary adenoma. | American Journal of Neuroradiology
Sequential MR enhancement pattern in normal pituitary gland and in pituitary adenoma.. W T Yuh, D J Fisher, H D Nguyen, E T ... These results suggest that pituitary adenomas have a direct arterial blood supply, similar to that of the posterior pituitary ... PURPOSE To measure and evaluate the temporal enhancement characteristics of the normal pituitary gland and pituitary adenoma. ... METHODS Thirty healthy subjects and 10 patients with sellar pituitary adenomas were studied prospectively using dynamic MR ...
Sporadic duodenal adenoma and colorectal neoplasia | Gut
This revealed a synchronous colonic adenoma in four patients (36%), three of which were tubulovillous adenomas and therefore ... Unfortunately, Murray et al provide no follow up data relating to the duodenal adenomas in their series. We have clinical data ... We read with great interest Murray et als article concerning the association between sporadic duodenal adenoma and colorectal ... We have also noted a lack of published literature regarding sporadic duodenal adenomas, with the exception of the two reports ...
Plus it
high-risk adenoma. LRA. low-risk adenoma. MRA. medium-risk adenoma. NPV. negative predictive value. PPV. positive predictive ... medium-risk adenomas, low-risk adenomas, benign polyps, and no findings on a colonoscopy). ... Stool-derived eukaryotic RNA biomarkers for detection of high-risk adenomas. Erica Barnell, Yiming Kang, Andrew Barnell, View ... Stool-derived eukaryotic RNA biomarkers for detection of high-risk adenomas Message Subject (Your Name) has forwarded a page to ...
Sebaceous adenomas of the eyelid and Muir-Torre Syndrome | British Journal of Ophthalmology
Keywords electron microscopy + adenoma + pituitary | PEIR Digital Library
Journey with a Parathyroid Adenoma | UCLA Health Connect
DDW: Diabetes Linked to Higher Adenoma Detection in 40s - MPR
... who undergo colonoscopy have a similar adenoma detection rate to those aged 50-59 years without DM. ... DDW: Diabetes Linked to Higher Adenoma Detection in 40s * Share on Facebook ... The researchers found that the adenoma detection rate was 14.4, 30.4, and 32% in those aged 40-49 without DM, 40-49 years with ... Compared to 40- to 49-year-olds without DM, the adenoma detection rate was significantly higher for those aged 40-49 with DM ( ...
Is non-functioning pituitary adenoma the cause of my hearing loss?
Its reports state that I have adenoma in my pituitary gland as big as a pea. Can this be the cause of hearing loss? I am a ... Is non-functioning pituitary adenoma the cause of my hearing loss?. Answered by: Dr (Prof) Santosh Kacker , Senior Consultant, ... Its reports state that I have adenoma in my pituitary gland as big as a pea. Can this be the cause of hearing loss? I am a ... It is not related to non-functioning pituitary adenoma. You can dive or swim. It is not directly related to hearing loss. ...
Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma. | Journal of Clinical...
RESULTS: There were 3305 traditional adenomas and 43 serrated adenomas. Serrated adenomas were more often found in the ... adenoma. METHODS: Colonoscopy records for 1995-1998 were reviewed, and all traditional adenomas and serrated adenomas ... AIM: Serrated adenoma is a recently described category of colorectal adenoma. The aim of this study was to determine whether ... Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma. ...