Adenoma: A benign epithelial tumor with a glandular organization.Adenoma, Pleomorphic: A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)Adenoma, Villous: An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.Adrenocortical Adenoma: A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.Adenoma, Liver Cell: A benign epithelial tumor of the LIVER.Adenoma, Chromophobe: A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.Growth Hormone-Secreting Pituitary Adenoma: A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Colonic Polyps: Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.ACTH-Secreting Pituitary Adenoma: A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.Adenoma, Acidophil: A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)Colonoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the colon.Adenomatous Polyps: Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)Prolactinoma: A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.Adenoma, Basophil: A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Adenomatous Polyposis Coli: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.Genes, APC: Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.Hyperparathyroidism: A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Colonic Neoplasms: Tumors or cancer of the COLON.Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Adrenal Gland Neoplasms: Tumors or cancer of the ADRENAL GLANDS.Pituitary ACTH Hypersecretion: A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Hyperaldosteronism: A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.Sphenoid Bone: An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Pituitary Gland: A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Hyperparathyroidism, Primary: A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Sella Turcica: A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND.Sigmoidoscopy: Endoscopic examination, therapy or surgery of the sigmoid flexure.Choristoma: A mass of histologically normal tissue present in an abnormal location.Rectal Neoplasms: Tumors or cancer of the RECTUM.Pituitary Apoplexy: The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.Human Growth Hormone: A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Pituitary Hormones: Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.Adenomatous Polyposis Coli Protein: A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.Parathyroidectomy: Excision of one or more of the parathyroid glands.Urethane: Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Adenoma, Bile Duct: A benign tumor of the intrahepatic bile ducts.Prolactin: A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.Colon, Descending: The segment of LARGE INTESTINE between TRANSVERSE COLON and the SIGMOID COLON.

Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. (1/4752)

Overexpression of cell surface glycoproteins of the CD44 family is an early event in the colorectal adenoma-carcinoma sequence. This suggests a link with disruption of APC tumor suppressor protein-mediated regulation of beta-catenin/Tcf-4 signaling, which is crucial in initiating tumorigenesis. To explore this hypothesis, we analyzed CD44 expression in the intestinal mucosa of mice and humans with genetic defects in either APC or Tcf-4, leading to constitutive activation or blockade of the beta-catenin/Tcf-4 pathway, respectively. We show that CD44 expression in the non-neoplastic intestinal mucosa of Apc mutant mice is confined to the crypt epithelium but that CD44 is strongly overexpressed in adenomas as well as in invasive carcinomas. This overexpression includes the standard part of the CD44 (CD44s) as well as variant exons (CD44v). Interestingly, deregulated CD44 expression is already present in aberrant crypt foci with dysplasia (ACFs), the earliest detectable lesions of colorectal neoplasia. Like ACFs of Apc-mutant mice, ACFs of familial adenomatous polyposis (FAP) patients also overexpress CD44. In sharp contrast, Tcf-4 mutant mice show a complete absence of CD44 in the epithelium of the small intestine. This loss of CD44 concurs with loss of stem cell characteristics, shared with adenoma cells. Our results indicate that CD44 expression is part of a genetic program controlled by the beta-catenin/Tcf-4 signaling pathway and suggest a role for CD44 in the generation and turnover of epithelial cells.  (+info)

MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene-environment interactions in colorectal tumorigenesis. (2/4752)

Our studies on interactions of a folate-metabolizing gene polymorphism and dietary intake in colorectal tumorigenesis demonstrate the potential importance of studying interactions between genotype and environmental exposure in relation to cancer risk. We observed an inverse association of a polymorphism (667C --> T, ala --> val) in the methylenetetrahydrofolate reductase (MTHFR) gene with colorectal cancer but not with colorectal adenomas. The inverse association of methionine and adverse association of alcohol with colorectal cancer were stronger among val/val individuals. These interactions were not present in studies of colorectal adenomas. Our studies illustrate that studying gene-environment interactions in relation to cancer can be of importance in clarifying cancer etiology as well as pointing to preventive dietary modifications.  (+info)

Expression of relaxin-like factor is down-regulated in human testicular Leydig cell neoplasia. (3/4752)

In addition to their role in steroidogenesis in the male, testicular Leydig cells constitutively express large amounts of the peptide relaxin-like factor (RLF), also known as Ley-IL. The Leydig cell-derived RLF belongs to the insulin-like superfamily, which also includes relaxin, insulin and the insulin-like growth factors, and within the testis is a specific marker of Leydig cells. Little information is available either on the regulation of gene expression or on the function of this Leydig cell-derived peptide. In the present study we have investigated the expression pattern of human RLF in patients with rare Leydig cell hyperplasia and adenoma. The expression of both mRNA and protein appear to be decreased in hyperplastic Leydig cells, whereas in the Leydig cell adenomas studied, large central areas of the adenoma were devoid of RLF mRNA and protein. Only Leydig cells located at the periphery of the adenoma displayed expression of RLF, with full agreement between in-situ hybridization and immunohistochemistry. It thus appears that the expression of the RLF gene and its products are down-regulated in Leydig cell hyperplasia and adenoma, consistent with a concomitant dedifferentiation of these cells.  (+info)

Effect of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis and aberrant crypt foci. (4/4752)

We have previously reported that the retinoids, 4-(hydroxyphenyl)retinamide (4-HPR) and 9-cis-retinoic acid (RA) prevented azoxymethane (AOM)-induced colon tumors and along with 2-(carboxyphenyl)retinamide (2-CPR) prevented aberrant crypt foci (ACF). In this study, we evaluated the effect of 2-CPR on AOM-induced colon tumors and the effect of the three retinoids on apoptosis and cell proliferation. Male F344 rats were administrated 15 mg/kg AOM at weeks 7 and 8 of age. 2-CPR (315 mg/kg) was administered in the diet starting either 1 week before or at week 12 after the first dose of AOM. The rats continued to receive the 2-CPR until killed at week 46. Unlike the demonstrated prevention of colon cancer by the other two retinoids, both dosing schedules of 2-CPR resulted in an approximate doubling of the yield of colon tumors. In adenomas, 2-CPR, 4-HPR and 9-cis-RA were equally effective in reducing mitotic activity, while only 4-HPR and 9-cis-RA but not 2-CPR enhanced apoptosis. When administered for only the 6 days prior to killing 4-HPR but not 2-CPR decreased the Mitotic Index and increased the Apoptotic Index in adenomas. In non-involved crypts, chronic exposure to 4-HPR and 9-cis-RA in contrast to 2-CPR reduced the Mitotic Index and enhanced the Apoptotic Index. In concurrence with our previous study, both 2-CPR and 4-HPR were very potent in preventing ACF when administered in the diet starting 1 week before the first dose of AOM and continuing for the 5 weeks of the study. Hence, unlike the other two retinoids, 2-CPR, although very potent in preventing ACF, enhanced rather than prevented AOM-induced colon cancer. Furthermore, our results suggest that the effect of 2-CPR on tumor yield is different from 4-HPR and 9-cis-RA because, unlike them, it does not enhance apoptosis.  (+info)

Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell. (5/4752)

Human methylguanine-DNA methyltransferase (MGMT) transgenic mice expressing high levels of O6-alkylguanine-DNA alkyltransferase (AGT) in lung were crossbred to A/J mice that are susceptible to pulmonary adenoma to study the impact of O6-methylguanine (O6mG)-DNA adduct repair on NNK-induced lung tumorigenesis. Expression of the chimeric human MGMT transgene in lung was identified by northern and western blot analysis, immunohistochemistry assay and enzymatic assay. AGT activity was 17.6 +/- 3.2 versus 1.2 +/- 0.4 fmol/microg DNA in lung of MGMT transgenic mice compared with non-transgenic mice. Immunohistochemical staining with anti-human AGT antibody showed that human AGT was expressed throughout the lung. However, some epithelial cells of bronchi and alveoli did not stain for human AGT, suggesting that the human MGMT transgene expression was heterogeneous. After 100 mg/kg NNK i.p. injection in MGMT transgenic mice, lung AGT activity remained much higher and levels of lung O6mG-DNA adducts in MGMT transgenic mice were lower than those of non-transgenic mice. In the tumorigenesis study, mice received 100 mg/kg NNK at 6 weeks of age and were killed 44 weeks later. Ten of 17 MGMT transgenic mice compared with 16 of 17 non-transgenic mice had lung tumors, P < 0.05. MGMT transgenic mice had lower multiplicity and smaller sized lung tumors than non-transgenic mice. Moreover, a reduction in the frequency of K-ras mutations in lung tumors was found in MGMT transgenic mice (6.7 versus 50% in non-transgenic mice). These results indicate that high levels of AGT expressed in mouse lung reduce lung tissue susceptibility to NNK-induced tumorigenesis due to increased repair capacity for O6mG, subsequently, decreased mutational activation of K-ras oncogene. Heterogeneity in the level of AGT expressed in different lung cell populations or other forms of carcinogenic DNA damage caused by NNK may explain the residual incidence of lung tumors in MGMT transgenic mice.  (+info)

Possible carcinogenic effects of X-rays in a transgenerational study with CBA mice. (6/4752)

A lifetime experiment using 4279 CBA/J mice was carried out to investigate whether the pre-conceptual exposure of sperm cells to X-ray radiation or urethane would result in an increased cancer risk in the untreated progeny, and/or increased susceptibility to cancer following exposure to a promoting agent. The study consisted of four main groups, namely a control group (saline), a urethane group (1 mg/g body wt) and two X-ray radiation groups (1 Gy, 2 Gy). At 1, 3 and 9 weeks after treatment, the males of these four parental groups were mated with untreated virgin females. The offspring of each parental group was divided into two subgroups: one received s.c. urethane (0.1 mg/g body wt once) as a promoter, the other saline, at the age of 6 weeks. All animals were evaluated for the occurrence of tumours. K-ras oncogene and p53 tumour suppressor gene mutations were investigated in frozen lung tumour samples. The female offspring of male parents exposed to X-rays 1 week before their mating showed a trend towards a higher tumour incidence of the haematopoietic system than the F1 controls. In addition, a higher percentage of bronchioloalveolar adenocarcinomas in male offspring born to irradiated paternals mated 1 week after X-ray treatment points to a plausible increased sensitivity of post-meiotic germ cell stages towards transgenerational carcinogenic effects. On the other hand, no increased tumour incidence and malignancy were observed in the offspring born to irradiated paternals mated 3 and 9 weeks after X-ray treatment. Paternal urethane treatment 1, 3 and 9 weeks prior to conception did not result in significantly altered incidence or malignancy of tumours of the lung, liver and haematopoietic tissue in the offspring. K-ras mutations increased during tumour progression from bronchioloalveolar hyperplasia to adenoma. Codon 61 K-ras mutations were more frequent in lung tumours of urethane-promoted progeny from irradiated parents than from control parents. P53 mutations were absent from these lung alterations.  (+info)

Epithelial thyroid tumors in cows. (7/4752)

From 1964 to 1973, 370 tumors were collected from cows of unknown age. Ten (2.7%) of these were primary thyroid tumors. Three were malignant. The benign tumors were solitary encapsulated adenomas in the parenchyma with more or less defined trabeculae, tubular, and microfollicular pattern. One of the malignant tumors was a cystic papillary adenocarcinoma, and two were small cell carcinomas consisting of small, sometimes binuclear, pleomorphic cells.  (+info)

The elevated serum alkaline phosphatase--the chase that led to two endocrinopathies and one possible unifying diagnosis. (8/4752)

A 39-year-old Chinese man with hypertension being evaluated for elevated serum alkaline phosphatase (SAP) levels was found to have an incidental right adrenal mass. The radiological features were characteristic of a large adrenal myelolipoma. This mass was resected and the diagnosis confirmed pathologically. His blood pressure normalised after removal of the myelolipoma, suggesting that the frequently observed association between myelolipomas and hypertension may not be entirely coincidental. Persistent elevation of the SAP levels and the discovery of hypercalcaemia after surgery led to further investigations which confirmed primary hyperparathyroidism due to a parathyroid adenoma. The patient's serum biochemistry normalised after removal of the adenoma. The association of adrenal myelolipoma with primary hyperparathyroidism has been reported in the literature only once previously. Although unconfirmed by genetic studies this association may possibly represent an unusual variation of the multiple endocrine neoplasia type 1 syndrome.  (+info)

In this large prospective study, higher intake of marine n-3 fatty acids was not associated with risk of distal colorectal adenoma. In addition, no significant associations were observed between this dietary variable and risks of small adenoma, distal colon adenoma, and rectal adenoma, although a nonsignificant, suggestive, inverse association was noted for large adenoma. Similarly, we found no significant associations between n-3/n-6 ratio and risks of distal colorectal adenoma.. We did find a suggestively decreased risk of large adenoma associated with higher dietary marine n-3 fatty acid intake (RR, 0.74; 95% CI, 0.54-1.01). Interestingly, we also noted that high n-3 intake was associated with a nonsignificant increase in risk of small adenoma. We thus conducted a post hoc analysis and found that among women with a diagnosis of adenoma, those with high dietary intake of marine n-3 fatty acids had a 46% lower odds of having a large adenoma versus a small adenoma. In combination, these results ...
Pituitary adenomas are tumors that occur in the pituitary gland. Pituitary adenomas are generally divided into three categories dependent upon their biological functioning: benign adenoma, invasive adenoma, and carcinomas. Most adenomas are benign, approximately 35% are invasive and just 0.1% to 0.2 are carcinomas. Pituitary adenomas represent from 10% to 25% of all intracranial neoplasms and the estimated prevalence rate in the general population is approximately 17%. Non-invasive and non-secreting pituitary adenomas are considered to be benign in the literal as well as the clinical sense; however a recent meta-analysis (Fernández-Balsells, et al. 2011) of available research has shown there are to date scant studies - of poor quality - to either support or refute this assumption. Adenomas which exceed 10 millimetres (0.39 in) in size are defined as macroadenomas, with those smaller than 10 mm referred to as microadenomas. Most pituitary adenomas are microadenomas, and have an estimated ...
We report for the first time that the fraction of ALDH1A1-expressing putative stem-like cells in colorectal adenoma epithelium is correlated among synchronous adenomas in individual patients, and that the presence of a larger subpopulation of these adenoma stem-like cells is associated with increased risk for the patient to have a metachronous adenoma at another location in the large bowel at follow-up. Of note, the association between percentage of ALDH1A1-expressing adenoma cells and risk of a metachronous adenoma is independent of both the adenoma and clinical characteristics previously reported to be associated with increased risk (i.e., villous architecture, high-grade dysplasia, and size of the baseline adenoma, and age and male sex of the study subjects). Our findings raise the possibility that a larger stem-like cell subpopulation in a baseline adenoma may serve as a quantifiable biomarker for the propensity of a patient to develop a subsequent colorectal neoplasm. If corroborated, this ...
Background: Sporadic adenoma formation found on surveillance colonoscopies in patients with inflammatory bowel disease (IBD) represents a significant risk for cancer. Certain racial groups like African Americans (AA) are at increased risk of developing colorectal cancer (CRC), but there is conflicting literature on differences in sporadic adenoma formation. Some data suggests AA are at increased risk for large adenomas, more proximal lesions, and increased prevalence. These data, however, are studying the general population and to our knowledge no study has looked at differences in adenoma formation by race in IBD patients. The present retrospective study analyzes the prevalence of adenomas in IBD patients. Methods: All IBD patients who received a surveillance colonoscopy within the past year were included in the present study. Sporadic adenomas included serrated, tubular, villous, and tubulovillous adenoma formation. A database was created using Microsoft Excel and identifying information was
A small study suggests that serrated adenoma may be a form of familial adenomatous polyposis (FAP) and not a separate type of colorectal cancer.. Three serrated adenomas were found separately in three out of 11 Japanese patients from three families with FAP. Colorectal polyps numbered ,100 in each of the three, and all serrated adenomas were found in the rectum. All three patients with serrated adenomas had mutations in the adenomatous polyposis coli (APC) gene-two proximal to the site of the gene, at codon 161, 332 and the third at the most distal site, codon 1556. Mutations in the other patients were located between codons 554 and 1324.. The rate of occurrence of serrated adenoma in the study was 30 times that in the general population so APC mutation may influence pathogenesis of serrated adenoma. The genetic results are compatible with a recent report describing colonic polyposis of ,100 polyps as attenuated FAP, so serrated adenoma may actually be a phenotype of FAP.. All 11 patients had a ...
Background & Objectives: Tubular adenomas are rare benign epithelial tumours of breast affecting predominantly females of child bearing age group. Till now, very small number of cases have been reported in the literature. Present study was carried out to evaluate the clinico-pathological features of tubular adenoma cases diagnosed during three years study period along with discussion of possible differential diagnoses. Methods: Overall, 346 female breast biopsies were diagnosed as benign lesions in three years (2010-2012), of which 10 cases of tubular adenomas were identified. Available clinical, radiological and cytological data of these cases were analysed retrospectively in detail. Result: Tubular adenomas were identified from 16 to 48 years of age with a predilection to younger age group (60% within 30 years). Most of the tubular adenomas were small and circumscribed mimicking fibroadenoma in almost all the cases. Diagnosis of tubular adenoma in each case was possible only after histological
Supplementation with fibre as ispaghula husk may have adverse effects on colorectal adenoma recurrence, especially in patients with high dietary calcium intake. Calcium supplementation was associated with a modest but not significant reduction in the risk of adenoma recurrence.
Pituitary Cancer. Pituitary tumors are unusual growths found in the pituitary organ which makes hormones that influence development and the functions of different glands in the body.. The pituitary organ is a pea-sized, reddish dim organ in the focal point of the brain, just above and behind the nose.. Pituitary carcinomas happen in both sexes, usually by the third or fourth decades of life. These tumors are very basic with 25% of individuals having small pituitary tumors on autopsy however most are sans symptom and the vast larger part of pituitary adenomas go undiagnosed all through life.. Types of Pituitary Tumors. The types are named after the types of hormones the pituitary makes and incorporate prolactin-delivering adenomas, somatotrophin-secreting adenomas, corticotrophin-secreting adenomas, gonadotrophin-secreting adenomas, thyrotrophin-secreting adenomas, invalid cell adenomas, and adenomas of the blended cell sort. Another kind of pituitary cancer shows up as substantial hands, feet ...
Medical information, Thyroid adenoma. Definition of Thyroid adenoma, symptoms of Thyroid adenoma, treatment of Thyroid adenoma, and prevention of Thyroid adenoma. Exams and Tests Thyroid adenoma.
Author(s): Meyskens, Frank L, Jr; McLaren, Christine E; Pelot, Daniel; Fujikawa-Brooks, Sharon; Carpenter, Philip M; Hawk, Ernest; Kelloff, Gary; Lawson, Michael J; Kidao, Jayashri; McCracken, John; Albers, C Gregory; Ahnen, Dennis J; Turgeon, D Kim; Goldschmid, Steven; Lance, Peter; Hagedorn, Curt H; Gillen, Daniel L; Gerner, Eugene W | Abstract: Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing adenomas with little additional toxicities, suggesting a strategy to improve risk to benefit ratios for preventing recurrent adenomas. Three hundred seventy-five patients with history of resected (> or =3 mm) adenomas were randomly assigned to receive oral difluoromethylornithine (DFMO) 500 mg and sulindac 150 mg once daily or matched placebos for 36 months, stratified by use of low-dose aspirin (81 mg) at baseline and clinical site. Follow-up colonoscopy was done 3 years after randomization or off-study. Colorectal adenoma recurrence was
TY - JOUR. T1 - Increased risk of adenomas in individuals with a family history of colorectal cancer. T2 - results of a meta-analysis. AU - Wilschut, Janneke A. AU - Habbema, J Dik F. AU - Ramsey, Scott D. AU - Boer, Rob. AU - Looman, Caspar W N. AU - van Ballegooijen, Marjolein. PY - 2010/12. Y1 - 2010/12. N2 - OBJECTIVE: It is unclear to what extent the increased risk of colorectal cancer in individuals with a family history of colorectal cancer and no known genetic disorders is associated with a higher adenoma prevalence. Our aim is to estimate the relative difference in adenoma prevalence and its age-pattern in individuals with a family history of colorectal cancer compared to those without.METHODS: We performed a literature search to identify colonoscopy studies reporting the adenoma prevalence by age. Using multilevel logistic regression, we examined how the adenoma prevalence by age differed between individuals with and without a family history of colorectal cancer. We excluded members of ...
The authors report a clinical case of alveolar adenoma presenting as a solitary pulmonary nodule which was positive to PET and deeply located in the lung. Few cases of alveolar adenomas have been reported in literature; these lesions are considered pulmonary neoplasms with benign behaviour, usually presenting as a peripheral or subpleural coin lesion; the PET activities of such neoplasms were unknown. The present clinical case was singular for the deep location of the nodule and its tight adhesion to left inferior pulmonary vein requiring a lobectomy. In addition, alveolar adenoma PET behaviour has been reported as light positivity.
Introduction Down-regulation of E-cadherin (CDH1) and epithelial-mesenchymal transition (EMT) are considered critical events for invasion and metastasis of colorectal carcinoma. Here we tested whether the important regulators of E-cadherin expression SNAI1 and TWIST1 are already detectable in human colorectal adenomas. Methods RNA was extracted from a set of randomly selected formalin-fixed and paraffin-embedded (FFPE) colorectal adenomas (n = 41) and normal colon mucosa (n = 10). Subsequently mRNA expression of CDH1, CDH2, SNAI1 and TWIST1 was analysed by quantitative RT-PCR analysis. CDH1 as well as SNAI1 protein expression were assessed by immunohistochemistry (IHC). Results SNAI1 mRNA was expressed in 78% (n = 32/41), TWIST1 mRNA in 41% (n = 17/41) and CDH2 mRNA in 41% (n = 17/41) of the colorectal adenoma tissue, while normal colon mucosa was negative for these transcription factors. We found a significant correlation between reduced CDH1 and the presence of SNAI1 mRNA expression and for
BACKGROUND: Colorectal cancer incidence is rapidly rising in many Asian countries, with rates approaching those of Western countries. This study aimed to evaluate the prevalence and trends of colorectal adenomas by age, sex, and risk strata in asymptomatic Koreans. METHODS: Cross-sectional study of 19,372 consecutive participants aged 20 to 79 years undergoing screening colonoscopy at the Center for Health Promotion of the Samsung Medical Center in Korea from January 2006 to June 2009. RESULTS: Among participants at average risk, those without a history of colorectal polyps or a family history of colorectal cancer, the prevalence of colorectal adenomas and advanced adenomas were 34.5% and 3.1%, respectively, in men and 20.0% and 1.6%, respectively, in women. The prevalence of adenomas increased with age in both men and women, with a more marked increase for advanced adenoma. Participants with a family history of colorectal cancer or with a history of colorectal polyps had significantly higher ...
TY - JOUR. T1 - Estimation of colorectal adenoma recurrence with dependent censoring. AU - Hsu, Chiu Hsieh. AU - Long, Qi. AU - Alberts, David S.. PY - 2009. Y1 - 2009. N2 - Background. Due to early colonoscopy for some participants, interval-censored observations can be introduced into the data of a colorectal polyp prevention trial. The censoring could be dependent of risk of recurrence if the reasons of having early colonoscopy are associated with recurrence. This can complicate estimation of the recurrence rate. Methods. We propose to use midpoint imputation to convert interval-censored data problems to right censored data problems. To adjust for potential dependent censoring, we use information from auxiliary variables to define risk groups to perform the weighted Kaplan-Meier estimation to the midpoint imputed data. The risk groups are defined using two risk scores derived from two working proportional hazards models with the auxiliary variables as the covariates. One is for the recurrence ...
Background: Use of multivitamins may reduce the risk of colorectal adenoma, but the duration of use needed is unclear. Methods: We prospectively examined years of multivitamin use and risk of colorectal adenoma among 43 641 women who had a first endoscopy between 1991 and 2007 in the Nurses Health Study II. Use of multivitamins was assessed through biennial questionnaires since 1989. Results: We documented 2277 colorectal adenoma cases. Reporting multivitamin use at any time during the study period compared with never reporting its use was associated with a reduced risk of adenoma (multivariable relative risk (RR)=0.86, 95% confidence interval (CI): 0.76-0.97). There was no clear trend with duration of multivitamin use: years of use compared with never use, ⩽4 years (RR=0.84, 95% CI: 0.74-0.96), 5-9 years (RR=0.89, 95% CI: 0.77, 1.02), 10-14 years (RR=0.86, 95% CI: 0.74, 1.01), 15-19 years (RR=0.85, 95% CI: 0.70, 1.02), and 20-26 years (RR=0.80, 95% CI: 0.64, 1.01); (P trend=0.87). The ...
Fingerprint Dive into the research topics of Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines. Together they form a unique fingerprint. ...
TY - JOUR. T1 - Increased risk of colorectal adenomas in Italian subjects carrying the p53 PIN3 A2-Pro72 haplotype. AU - Perfumo, Chiara. AU - Bonelli, Luigina. AU - Menichini, Paola. AU - Inga, Alberto. AU - Gismondi, Viviana. AU - Ciferri, Enrico. AU - Percivale, Pierluigi. AU - Bianchi Scarrà, Giovanna. AU - Nasti, Sabina. AU - Fronza, Gilberto. AU - Varesco, Liliana. PY - 2007/4. Y1 - 2007/4. N2 - Background: Few reports have investigated the association of two p53 polymorphisms (Arg72Pro and PIN3-A2) with colorectal cancer (CRC) risk, and no previous study has analyzed their role as susceptibility alleles for colorectal adenoma. Aim: To explore the impact of the p53 PIN3-Arg72Pro haplotype on colorectal adenoma formation and progression to cancer. Methods: One hundred and eighty-four colorectal tumor patients (124 with adenomas and 60 with adenocarcinoma) and 188 controls (42 subjects with a clean colon, 54 hospital controls and 92 blood donors) from the Italian population were tested for ...
Background: Colorectal adenomas are precursor lesions of colorectal cancer. About 5% of colorectal adenomas are estimated to progress to colorectal cancer (CRC). The currently used histo-pathological characteristics to identify adenomas at risk of malignant progression, i.e. scoring of size ≥ 10mm, villous component or high grade dysplasia, are not sufficiently sensitive and specific and prone to inter-observer variability. Integrating molecular markers reflecting the underlying biology of CRC into the current classification system is expected to better characterize adenomas at high-risk of progression.. Aim: Here we compared the prevalence of genetic changes, in particular DNA copy number changes, between advanced and non-advanced adenomas.. Methods: Formalin-fixed paraffin-embedded tissue samples from 121 patients (mean age 65.4±11.6, 52.9% male) with colorectal adenomas (63 non-advanced adenomas and 58 advanced adenomas) were retrospectively collected from the archives of the department of ...
TY - JOUR. T1 - Frequent nuclear accumulation of β-catenin in pituitary adenoma. AU - Semba, Shuho. AU - Han, Shuang Yin. AU - Ikeda, Hidetoshi. AU - Horii, Akira. PY - 2001/1/1. Y1 - 2001/1/1. N2 - BACKGROUND. β-catenin (CTNNB1) is known to be a member of the cadherin-catenin superfamily and to function in cell-cell adhesion. However, it also has been reported that CTNNB1 plays an important role in carcinogenesis. In the current study, the authors observed expression of the CTNNB1 protein in primary pituitary adenomas to investigate the role of CTNNB1 in the development of pituitary adenomas. METHODS. A total of 37 pituitary adenomas were analyzed. Expression of CTNNB1 and the cell proliferation marker Ki-67 were observed immunohistochemically. In addition, the authors performed direct sequencing to detect somatic mutations of exon 3 of the CTNNB1 gene. RESULTS. Twenty-one of 37 pituitary adenomas (57%) demonstrated abnormal nuclear accumulation of CTNNB1. It is interesting to note that ...
Serrated adenomas form a distinct subtype of colorectal pre-malignant lesions that may progress to malignancy along a different molecular pathway than the conventional adenoma-carcinoma pathway. Previous studies have hypothesised that BRAF mutation and promoter hypermethylation plays a role, but the evidence for this is not robust. We aimed to carry out a whole-genome loss of heterozygosity analysis, followed by targeted promoter methylation and expression analysis to identify potential pathways in serrated adenomas. An initial panel of 9 sessile serrated adenomas (SSA) and one TSA were analysed using Illumina Goldengate HumanLinkage panel arrays to ascertain regions of loss of heterozygosity. This was verified via molecular inversion probe analysis and microsatellite analysis of a further 32 samples. Methylation analysis of genes of interest was carried out using methylation specific PCR (verified by pyrosequencing) and immunohistochemistry used to correlate loss of expression of genes of interest. All
The mechanism of prostate adenoma development is not yet fully defined. Despite the popular belief that prostate adenoma is associated with chronic prostatitis, there is no data that would confirm the link between these two diseases. The researchers found no Association between the development of prostate adenoma and alcohol and tobacco use, sexual orientation, sexual activity, and venereal and inflammatory diseases.. There is a pronounced dependence of the frequency of prostate adenoma on the age of the patient. Scientists believe that prostate adenoma develops as a result of hormonal disorders in men with the onset of andropause (male menopause). This theory is supported by the fact that prostate adenoma never affects men who are castrated before puberty and, extremely rarely, men who are castrated after puberty.. There are two groups of symptoms of prostate adenoma:. ...
In this large cross-sectional study of asymptomatic men and women attending a health screening program, among those at average risk of colorectal adenoma we found that 34.5% of men and 20.0% of women had prevalent colorectal adenomas, and 3.1% of men and 1.6% of women had prevalent advanced adenomas. The prevalence of colorectal adenomas and of advanced adenomas increased significantly with age in both men and women, particularly for multiple, larger, and advanced adenomas. The prevalence of adenomas increased annually over the study period in both men and women.. Our estimates of the prevalence of colorectal adenomas are consistent with previous studies based on more selected and smaller screening samples (7, 11). In one study, the prevalence of colorectal adenomas among average risk asymptomatic Koreans 50 years of age or older were 39.9% and 23.0% among men and women, respectively (7), whereas in another study, the prevalence among Korean men 40 to 69 years of age was 36.3% (11). These ...
BACKGROUND & AIMS Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α), two important inflammatory cytokines, have been inconsistently associated with risk of colon neoplasia in epidemiological studies. However, research to date has not adequately assessed whether race-specific differences may exist in associations between biomarkers and genetic variants of these cytokines and colorectal adenoma - the precursor lesions of colorectal cancer. We sought to determine whether circulating levels of IL-6 and TNF-α, or genetic polymorphisms in IL-6and TNF-α were associated with colon adenoma and if so, whether that association differed by race. METHODS We analyzed the associations of circulating levels and single nucleotide polymorphisms (SNPs) of IL-6 and TNF-α with risk of colon adenomas in a colonoscopy -based case-control study of 401 incident adenoma cases and 1,050 controls. We used multivariate unconditional logistic regression models to estimate the odds ratios (OR) and 95% confidence
TY - JOUR. T1 - Risk stratification of individuals with low-risk colorectal adenomas using clinical characteristics. T2 - A pooled analysis. AU - Gupta, Samir. AU - Jacobs, Elizabeth T.. AU - Baron, John A.. AU - Lieberman, David. AU - Murphy, Gwen. AU - Ladabaum, Uri. AU - Cross, Amanda J.. AU - Jover, Rodrigo. AU - Liu, Lin. AU - Martinez, Maria Elena. PY - 2017/3/1. Y1 - 2017/3/1. N2 - Objective For individuals with 1-2 small (,1 cm) low-risk colorectal adenomas, international guidelines range from no surveillance to offering surveillance colonoscopy in 5-10 years. We hypothesised that the risks for metachronous advanced neoplasia (AN) among patients with low-risk adenomas differ based on clinical factors distinct from those currently used. Design We pooled data from seven prospective studies to assess the risk of metachronous AN. Two groups with 1-2 small adenomas were defined based on guidelines from the UK (n=4516) or the European Union (EU)/US (n=2477). Results Absolute risk of ...
TY - JOUR. T1 - CT and ultrasound features of metanephric adenoma in adults with pathologic correlation. AU - Fielding, Julia R.. AU - Visweswaran, Aparna. AU - Silverman, Stuart G.. AU - Granter, Scott R.. AU - Renshaw, Andrew A.. PY - 1999/5/1. Y1 - 1999/5/1. N2 - Purpose: The purpose of this work was to correlate the CT, ultrasound, and pathologic features of metanephric adenoma, a rare benign renal tumor in adults. Method: Retrospective review of medical records (1990-1997) revealed three adult female patients who had both preoperative imaging and nephrectomy with pathologic diagnosis of metanephric adenoma performed at our institution. CT (n = 3) and ultrasound (n = 2) features were reviewed in consensus by two radiologists and correlated with pathologic findings. Results: In all three cases, the metanephric adenoma was of increased attenuation relative to adjacent renal parenchyma on unenhanced CT scans. No septa or calcifications were seen. Ultrasound images showed both tumors to be ...
Obesity is a known risk factor for colon cancer and higher body mass index (BMI) has been associated with colorectal adenomas, which are precursor lesions to most colorectal cancers. Polymorphisms in the fat-mass and obesity-associated (FTO) gene have been associated with BMI and larger effects in older versus younger children have been reported. However, no studies have examined associations between FTO polymorphisms, BMI throughout adulthood and colorectal adenomas. Therefore, we evaluated associations between FTO polymorphisms (rs1421085, rs17817449, rs8050136, rs9939609, rs8044769), adult BMI (at recruitment, 50s, 40s, 30s, 20s age decades) and colorectal adenomas in 759 Caucasians and 469 African-Americans. We found that the highest versus the lowest BMI tertile at recruitment [odds ratio (OR) = 1.82; 95% confidence interval (CI): 1.07-2.16] and in the 30s (OR = 1.50; 95% CI: 1.04-2.15) was associated with higher adenoma risk. Stratification by ethnicity revealed that these associations ...
RESULTS. VEGF121 and VEGF165 were expressed in 65 % and 75% respectively of the adenomas and the level of this expression varied greatly. There was no correlation between expression of the two receptors or between VEGF expression and adenoma type. Only two adenomas didnt express any VEGF. VEGF-R1 and VEGF-R2 were expressed in 35 % and 25 % respectively of the adenomas and the level of this expression again varied greatly. There was no correlation between receptor expression and VEGF expression, or receptor expression and adenoma type. 55 % of the adenomas didnt express any receptor. Only one adenoma was found not to express any VEGF or receptor ...
The team performed a case-control study in 18 endoscopic units of French nonuniversity hospitals.. A colonoscopy was offered to first-degree relatives of 306 index cases with adenomas of 10 mm if they were alive, aged 40 to 75 years.. Among them, 168 were examined and matched for age, sex, and geographical area with 307 controls.. Controls were randomly selected from 1362 consecutive patients aged 40 to 75 years having undergone a colonoscopy for minor symptoms.. The researchers found the prevalence of large adenomas and cancers was 8% and 4%, in relatives and controls, respectively.. Odds ratios associated with a history of large adenomas in relatives were 2.3 with cancers or large adenomas, 1.2 for small adenomas, and 1.6 for all colorectal neoplasia.. The team found the risk of large adenomas and cancers was higher in relatives of index cases younger than 60 years.. In addition, the research team noted that the risk of large adenomas and cancers was higher when the index case had large distal ...
Colorectal cancer screening is recommended for average-risk persons beginning at age 50. A family history of colorectal cancer is recognized as a risk factor for colorectal adenoma. However, the strength of this association is uncertain. Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer have proved controversial. The conflicting recommendations are partly attributable to the lack of data about the prevalence of CRC and adenomas among 30- to 49-year-old individuals with a first relative history of colorectal cancer. This prospective study will quantify the prevalence of adenomas (any size) and advanced adenomas among 30- to 49-year-old individuals undergoing their first screening colonoscopy because of a first relative history of colorectal cancer and compare the data with controls(asymptomatic subjects without a first relative history of colorectal cancer ...
TY - JOUR. T1 - Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. AU - Adegboyega, Patrick A.. AU - Ololade, Omiyosoye. AU - Saada, Jamal. AU - Mifflin, Randy. AU - Di Mari, John F.. AU - Powell, Don W.. PY - 2004/9/1. Y1 - 2004/9/1. N2 - Purpose: Recent data support the hypothesis that the inducible isoform of cyclooxygenase (COX-2) plays a role in the early stages of colonic carcinogenesis and that nonsteroidal anti-inflammatory drugs (NSAIDs) retard the development of colon cancer by modulating COX-2. However, the cell types responsible for producing COX-2 in colorectal adenomas remain a subject of controversy. Experimental Design: COX-2 expression in normal colonic mucosa (n = 50), hyperplastic polyps (n = 43), sporadic adenomas (n = 67), and invasive colonic adenocarcinoma (n = 39) was studied in formalin-fixed and paraffin-embedded tissue sections from endoscopy biopsy and colonic resection specimens. Immunohistochemistry (avidin-biotin complex technique ...
They recorded the characteristics of any adenomas using standardized protocol. Characteristics were recorded at baseline and at 3 years.. The main outcomes measured by the team were the 3-year overall recurrence, recurrence of multiple and advanced adenomas, and proximal and distal recurrence.. The researchers observed a 3-year recurrence 22% of patients. More than 50% had recurrent adenomas on the proximal colon. After adjustment, the team found that the number of adenomas and their proximal location at baseline were the main predictors of recurrence. When compared with patients who had 1 or 2 adenomas on the distal colon, patients with ≥3 adenomas with at least one of these on the proximal colon had a greater risk of overall recurrence (5.3). These patients also had a greater risk of proximal recurrence (8.5), and advanced adenoma recurrence (5.5).. Dr Bonithon-Kopps team concluded, "Follow-up colonoscopies in patients with adenomas should include careful examination of the proximal colon". ...
Pituitary adenomas are tumors that occur in the pituitary gland divided in three categories: benign adenoma, invasive adenoma, or carcinomas. Pituitary adenomas are tumors that occur in the pituitary gland. They are generally divided into three categories dependent upon their biological functioning: benign adenoma, invasive adenoma, or carcinomas, with carcinomas accounting for 0.1% to 0.2%, approximately. Read More…. Read More.... ...
NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. We examined the relationship between NQO1C609T, mEH3, mEH4 and risk of sporadic distal colorectal adenomas in one of the largest case-control studies of 946 polyp-free controls and 894 cases, all participants of the UK Flexible Sigmoidoscopy Screening (UKFSS) Trial. The polymorphisms were examined as independent risk factors and evidence for interaction with smoking and alcoholic drinks was sought. The NQO1 609*T allele was positively associated with high-risk adenoma in this population [odds ratio (OR), 1.36; 95% confidence interval (CI), 1.02-1.83]. Elevated risk estimates were seen in smokers independently of the genotype but the association was stronger among current smokers with ...
Če se ne sprejmejo terapevtski ukrepi, se pri bolnikih z adenomi prostate lahko razvije kronična ledvična odpoved. Pri adenoma prostate se včasih razvije akutno zadrževanje urinov. Pacient ne more urinirati, ko je mehur je poln, kljub intenzivni želji. Za odpravo zadrževanja sečnice se pri moških kateterizira mehur, včasih pa je nujna operacija ali prebadanje mehurja.. Še en zaplet pri adenoma prostate je hematurija. Pri številnih bolnikih je opaziti mikroekemurozo, vendar se pojavijo tudi pogoste intenzivne krvavitve iz tkiva adenoma (v primeru poškodb zaradi manipulacije) ali krčne žile na območju vratu mehurja. S tvorjenjem strdkov je mogoče razviti tamponado mehurja, v katerem je nujna kirurgija potrebna. Pogosto vzrok krvavitve v adenoma prostate postane diagnostična ali terapevtska kateterizacija.. Kamni mehurja pri adenoma prostate lahko nastanejo zaradi stoječega urin ali migrirajo iz ledvic in sečil. Pri cistolitiaziji se klinična slika adenoma prostate dopolnjuje s ...
Medical information, Adenoma - secreting. Definition of Adenoma - secreting, symptoms of Adenoma - secreting, treatment of Adenoma - secreting, and prevention of Adenoma - secreting. Exams and Tests Adenoma - secreting.
Among women at high risk for cardiovascular disease, daily supplementation with a combination of folic acid, vitamin B6, and vitamin B12 did not affect the risk of colorectal adenoma, a post hoc analy
Incidence of colorectal lesions with respect to high grade dysplasia, adenomas with villous features, adenomas 1 cm or greater, multiple adenomas, polyps ,/= 0.3 cm, total advanced colorectal events (defined as the number of patients with at least one high risk adenoma, 2nd primary colorectal cancer, colorectal cancer recurrence, or metastasis) or total colorectal cancer events (defined as the number of patients with at least one advanced colorectal event or polyp)at 3 years and 8 years ...
TY - JOUR. T1 - Novel patterns of gene expression in pituitary adenomas identified by complementary deoxyribonucleic acid microarrays and quantitative reverse transcription-polymerase chain reaction. AU - Evans, Chheng Orn. AU - Young, Andrew N.. AU - Brown, Milton R.. AU - Brat, Daniel J.. AU - Parks, John S.. AU - Neish, Andrew S.. AU - Oyesiku, Nelson M.. PY - 2001. Y1 - 2001. N2 - Pituitary adenomas account for approximately 10% of intracranial tumors, but little is known of the oncogenesis of these tumors. The identification of tumor-specific genes may further elucidate the pathways of tumor formation. We used complementary DNA microarrays to examine gene expression profiles in nonfunctioning, PRL, GH, and ACTH secreting adenomas, compared with normal pituitary. Microarray analysis showed that 128 of 7075 genes examined were differentially expressed. We then analyzed three genes with unique expression patterns and oncogenic importance by RT-real time quantitative PCR in 37 pituitaries. ...
The majority of people with adrenal adenomas will have no symptoms and the growths will only be discovered during a MRI or CT completed for other reasons. These non-functioning adrenal adenomas do not require follow up treatment.. Functional adrenal adenomas will increase hormones made in the adrenal gland.. ...
Background: The transition from normal epithelium to adenoma and, to invasive carcinoma in the human colon is associated with acquired molecular events taking 5-10 years for malignant transformation. We discovered CCAT1, a non-coding RNA over-expressed in colon cancer (CC), but not in normal tissues, thereby making it a potential disease-specific biomarker. We aimed to define and validate CCAT1 as a CC-specific biomarker, and to study CCAT1 expression across the adenoma-carcinoma sequence of CC tumorigenesis.Methods: Tissue samples were obtained from patients undergoing resection for colonic adenoma(s) or carcinoma. Normal colonic tissue (n = 10), adenomatous polyps (n = 18), primary tumor tissue (n = 22), normal mucosa adjacent to primary tumor (n = 16), and lymph node(s) (n = 20), liver (n = 8), and peritoneal metastases (n = 19) were studied. RNA was extracted from all tissue samples, and CCAT1 expression was analyzed using quantitative real time-PCR (qRT-PCR) with confirmatory in-situ ...
Da bi zmanjšali te zaplete po odstranitvi adenoma zdravniki prostate spremenjeno sestavo raztopine, izboljšanje medicinske opreme, prilagojene tehniko operacije. Po statističnih podatkih se takšne posledice pojavljajo z rednostjo približno 0,1 - 6,5%. težave uriniranje. Po odstranitvi adenoma prostate se nekaj časa ohranja erektilna funkcija. Težavo odpravite na več načinov: Uporaba inhibitorjev fosfodiesteraze-5 (iFDE-5) 30 dni po operaciji. Ti vključujejo: sildenafil, tadalafil, vardenafil. Ta metoda se izvaja, da se prepreči rast vezivnega tkiva in pojav brazgotin.Če ste pred operacijo imeli težave z močjo, potem je lahko po resnih težavah z erekcijo. Da bi se moško spolno življenje vrnilo v normalno stanje po odstranitvi prostate, Odstranitev adenoma prostate - kakšne so posledice operacije? Vadba po odstranitvi raka prostate bolečina v povečanje spolne moči in Prostatitis in njen vpliv na partnerja zdravljenje adenoma problemi z erekcijo forum. Kirurgija za adenoma ...
Pri moškem v 72 letih je prišlo do adenoma prostate. Obrnil se je k zdravniku, ko je bila bolezen že v zanemarjeni obliki, brez katetra pa ni bilo mogoče izprazniti mehurja. Takoj je ponudil operacijo za odstranitev adenoma, se je strinjal, odšel v bolnišnico, a ko sem videl post-kirurške bolnike, prestrašeni, izkazalo, da je z operacijo in je bil zaključen domov s katetrom. Po nasvetu urologu začel zdravljenje adenoma folk pravna sredstva: prvi dan posta mora jesti 0,5 skodelice orehov, v drugem - pol skodelice sončničnih semen, tretji dan od povprečja žarnice. Nadaljevati to zdravljenje prostate za tri mesece.. Moški je to zdravilo uporabljal in adenoma je izginila, a ker je imel nezdrav način življenja, se je nekaj let kasneje ponovno pojavil. Potem se je odločil, da bi adenoma zdravil z magnetom. Kupil je biokorrektorja iz podjetja Nevoton, vendar je bil učinek zdravljenja majhen. Potem je po mnenju zdravnika moški večkrat vzel magnet - od zvočnika radia. Poleg adenomom ...
TY - JOUR. T1 - Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas. AU - Carvajal-Carmona, Luis. AU - Zauber, Ann G.. AU - Jones, Angela M.. AU - Howarth, Kimberley. AU - Wang, Jiping. AU - Cheng, Timothy. AU - Riddell, Robert. AU - Lanas, Angel. AU - Morton, Dion. AU - Bertagnolli, Monica M.. AU - Tomlinson, Ian. PY - 2013/1. Y1 - 2013/1. N2 - Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842, rs4444235, rs1957636, rs4939827, and rs961253) were over-represented in CRC-free patients with adenomas, compared with controls. Ten other CRC-associated SNPs (rs6691170, rs6687758, rs16892766, rs7136702, rs11169552, rs4779584, rs9929218, rs10411210, rs4813802, and rs4925386) were not ...
• Benign adenomas in the colon increased slightly in participants using statins. • Preliminary data suggesting statins may prevent colorectal cancer were not supported by this secondary analysis. WASHINGTON, D.C. - Statins did not protect patients against colorectal adenomas, which are benign precursors of colorectal cancer, according to results of a secondary analysis of the…
Method for the prevention of colonic adenomas in mammals at risk of developing them by administering to such mammals an effective colonic adenoma preventive amount of ursodiol or a pharmaceutically acceptable salt conjugation product thereof.
King, D W.; Bock, F G.; and Moore, G E., "Dinitrophenol inhibition of pituitary adenoma formation in mice fed propylthiouracil." (1963). Subject Strain Bibliography 1963. 586 ...
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Two things may happen to adenomas over time: they increase in size and number. Adenomas form initially in the rectum and lower colon. Some people have hundreds or thousands of adenomas while others, particularly adolescents, may have fewer adenomas. One hundred polyps is the average number of polyps in a person with FAP but this depends on how old he or she is. This can be an important clue to treatment. Without early diagnosis and treatment, the risk of colon cancer is 100 per cent. FAP is a pre-cancerous disease because ...
Two things may happen to adenomas over time: they increase in size and number. Adenomas form initially in the rectum and lower colon. Some people have hundreds or thousands of adenomas while others, particularly adolescents, may have fewer adenomas. One hundred polyps is the average number of polyps in a person with FAP but this depends on how old he or she is. This can be an important clue to treatment. Without early diagnosis and treatment, the risk of colon cancer is 100 per cent. FAP is a pre-cancerous disease because ...
Adenoma yes [35] Mucinous adenocarcinoma [18] Squamous papilloma yes vaginal micropapillomatosis [16][17][18] ...
Summary: Associated Cancers: colorectal and ovarian cancer; pilomatrixoma; medulloblastoma; pleomorphic adenomas; malignant ... pleomorphic adenomas, and malignant mesothelioma. While less is known about the exact mechanism of α-catenin, its presence in ... "The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the β-catenin signaling pathway". ...
Nipple adenoma. Related subjects. *Main article. *Classification. *Risk factors (Alcohol, Hereditary breast-ovarian cancer ...
... to the point of suppressing the activity of the rest of the gland-is usually a thyrotoxic adenoma, a surgically curable form of ... nodule or lobe of the thyroid is sometimes removed for biopsy or because of the presence of an autonomously functioning adenoma ...
The older names, "multiple endocrine adenomas" and "multiple endocrine adenomatosis" (MEA), have been replaced by the current ... In 1903 Erdheim described the case of an acromegalic patient with a pituitary adenoma and three enlarged parathyroid glands. ... In 1961 Sipple described a combination of a pheochromocytoma, medullary thyroid carcinoma and parathyroid adenoma. ...
Pleomorphic adenoma. References[edit]. *^ Witt, Robert L., ed. (2005). "Chapter 9 "Benign tumors, cysts, and tumor-like ... Though much less likely to occur than pleomorphic adenoma, Warthin's tumor is the second most common benign parotid tumor. ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Tubular Adenoma (Villous, Tubulovillous) Tubular glands with elongated nuclei (at least low-grade atypia) Yes ... Villous adenomas are commonly found in the rectal area and they are normally larger in size than the other two types of ... Traditional Serrated Adenoma Serrated crypts, often villous architecture, with cytologic atypia, eosinophilic cells Yes ... Adenomatous polyps, or adenomas, are polyps that grow on the lining of the colon and which carry a high risk of cancer. The ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Canalicular adenoma • Canine tooth • Cantilever mechanics • Carbon dioxide laser • Caries vaccine • Carnassial • Case School of ... Pleomorphic adenoma • Pleurodont • Plica fimbriata • Polk E. Akers • Polymorphous low-grade adenocarcinoma • Polynoxylin • ...
"Parathyroid Adenoma". Archived from the original on 2011-07-16. Carrol, Mary F.; David S. Schade (1 May 2003). "A Practical ... Primary hyperparathyroidism in 80% of cases is due to a single benign tumor known as a parathyroid adenoma with most of the ... Parathyroid adenomas are very rarely detectable on clinical examination. Surgical removal of a parathyroid tumor eliminates the ... There is oversecretion of PTH due to a parathyroid adenoma, parathyroid hyperplasia or, rarely, a parathyroid carcinoma. This ...
It is able to pick up 80 percent of colorectal cancer and 44 percent for adenoma , 1 centimeter, while gFOBT picks up 13 to 50 ...
Emergencies arising from decompensated pheochromocytomas or parathyroid adenomas are sometimes referred for emergency resection ... "A parathyroid adenoma: benign disease presenting with hyperparathyroid crisis". Case Reports in Medicine. 2010: 596185. doi ...
TCF4 Pituitary adenoma, ACTH-secreting; 219090; AIP Pituitary adenoma, growth hormone-secreting; 102200; AIP Pituitary adenoma ... PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, salivary gland pleomorphic; 181030; PLAG1 Adenomatous polyposis ... EIF2B4 Leydig cell adenoma, somatic, with precocious puberty; 176410; LHCGR Leydig cell hypoplasia with hypergonadotropic ... SCN4A Parathyroid adenoma with cystic changes; 145001; HRPT2 Parathyroid carcinoma; 608266; HRPT2 Parietal foramina 1; 168500; ...
A parathyroid adenoma is a noncancerous (benign) tumor of the parathyroid glands. The parathyroid glands are located in the ... Most parathyroid adenomas do not have an identified cause. Sometimes a genetic problem is the cause. This is more common if the ... A parathyroid adenoma is a noncancerous (benign) tumor of the parathyroid glands. The parathyroid glands are located in the ... Parathyroid adenomas are the most common cause of hyperparathyroidism (overactive parathyroid glands), which leads to an ...
Hepatocellular adenoma (also known as hepatic adenoma or hepadenoma) is a rare, benign liver tumor. It most commonly occurs in ... The histologic diagnosis of hepatic adenomas can be aided by reticulin staining. In hepatic adenomas, the reticulin scaffold is ... Pregnancy could cause the adenoma to grow faster, so patients with hepatic adenomas should avoid pregnancy.[10] ... "Hepatocellular Adenoma: eMedicine Gastroenterology".. *^ a b c Anthony S. Fauci; Eugene Braunwald; Dennis L. Kasper; Stephen L ...
A parathyroid adenoma is a benign tumor of the parathyroid gland. It generally causes hyperparathyroidism; there are very few ... Oftentimes parathyroid adenoma is not diagnosed until found on standard blood-tests that reveal high calcium content in the ... Parathyroid adenoma can be associated with overexpression of the cyclin D1 gene. Hyperparathyroidism is confirmed by blood ... sometimes parathyroid adenomas can be ablated by ethanol injection, guided by ultrasound. Endocrine system Parathyroid disease ...
Synonyms: Pituitary gland Basophilic adenoma, mucoid cell adenoma, basophilic pituitary gland adenoma, Adenoma, Basophil, ... pituitary gland basophilic adenoma, pituitary gland basophil adenoma, basophilic adenoma, pituitary basophilic adenoma ...
Diagnosis and treatment of pituitary adenomas: a review. JAMA. 2017;317(5):516-24.CrossRefPubMedGoogle Scholar ... Prevalence of pituitary adenomas. Clin Endocrinol. 2010;72(3):377-82.CrossRefGoogle Scholar ... Okamoto Y, Okamoto F, Hiraoka T, Yamada S, Oshika T. Vision-related quality of life in patients with pituitary adenoma. Am J ... The incidence rate of pituitary adenomas in western Sweden for the period 2001-2011. Eur J Endocrinol. 2014;171(4):519-26. ...
Bronchial Adenoma. Br Med J 1954; 1 doi: https://doi.org/10.1136/bmj.1.4875.1362 (Published 12 June 1954) Cite this as: Br Med ...
Aldosterone-producing adenomas are caused by mutations in one of several genes. The most commonly mutated gene is KCNJ5, ... An aldosterone-producing adenoma is a noncancerous (benign) tumor that develops in an adrenal gland, which is a small hormone- ... Aldosterone-producing adenomas are generally not inherited but arise from a mutation in the bodys cells that occurs after ... Aldosterone-producing adenomas cause up to 60 percent of cases of primary hyperaldosteronism. It is estimated that primary ...
An adrenal gland adenoma is a tumor on your adrenal gland that isnt cancer, but can still cause problems. Learn what causes ... If you have an adrenal gland adenoma, you have a tumor on your adrenal gland, but its not cancer. Your two adrenal glands, one ... Most adrenal gland adenomas dont cause any problems -- they just take up space. But some of them are functioning tumors -- ... Doctors dont know what causes adrenal gland adenomas, but youre more likely to get one if you have certain genetic conditions ...
Retrieved from "https://en.wiktionary.org/w/index.php?title=adenomas&oldid=45977831" ...
Periampullary adenoma causing pancreatitis. Br Med J (Clin Res Ed) 1981; 283 :527 ... Periampullary adenoma causing pancreatitis.. Br Med J (Clin Res Ed) 1981; 283 doi: https://doi.org/10.1136/bmj.283.6290.527 ( ...
Table 2. Imaging markers of aggressive pituitary adenoma Imaging markers of aggressive pituitary adenoma. ... Pituitary adenomas are benign, slow-growing neoplasms in the majority of cases, with an incidence of clinically relevant ... Even standard pituitary adenomas exhibit relatively high long-term recurrence rates and delayed intervention is often required ... The prevalence of aggressive pituitary adenoma is not known and furthermore, the exact definition of these tumours in the ...
... was found to have Pituitary Adenoma( on CT and MRI), of size .8 x 1 cm, located within the confines of sella Turcica. It is ... Pituitary Adenoma Arifa10 Three weeks ago, my daughter, aged 17 years, was found to have Pituitary Adenoma( on CT and MRI), of ... Pituitary Adenoma. Three weeks ago, my daughter, aged 17 years, was found to have Pituitary Adenoma( on CT and MRI), of size .8 ... For adenoma we are given 2 options to choose from, either to go for surgery( Trans- sphenoidal or through skull) or ...
Toxic thyroid adenoma (TA) is a well-encapsulated homogeneous neoplasia secreting thyroid hormones in the absence of a TSH ... Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas. J Clin Invest. 2016;126(9):3383-8.PubMedPubMedCentral ... Toxic adenoma Toxic multinodular goiter Goiter TSH receptor mutations Cell proliferation Hyperthyroidism 131-I therapy Surgical ... Toxic thyroid adenoma (TA) is a well-encapsulated homogeneous neoplasia secreting thyroid hormones in the absence of a TSH ...
Definition of hepatocellular adenoma. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... Synonym(s): hepatic adenoma. Further information. Always consult your healthcare provider to ensure the information displayed ...
... are also known as hepatic adenomas or liver cell adenomas. They are rare, benign tumors of presumable epithelial origin and ... Hepatocellular adenomas (HCAs) are also known as hepatic adenomas or liver cell adenomas. They are rare, benign tumors of ... encoded search term (Hepatocellular Adenoma) and Hepatocellular Adenoma What to Read Next on Medscape. Related Conditions and ... In addition to a multiplicity of adenomas, hepatic adenomas associated with GSD tend to occur more commonly in men than women ( ...
Adenoma, อะดีโนมา (th); acinar cell adenoma, acinar cell adenoma (morphologic abnormality), acinic cell adenoma, adenomas (en ... Adenoma (lt); Adenóm (sk); Adenoma (tl); Gruczolak (pl); เนื้องอกต่อม (th); Adenoma (id); adenom (nn); adenom (nb); adenoom (nl ... adenoma (it); adenoma (en); adénome (fr); Adenooma (fi); Adenoom (et); Adenom (tr); Ադենոմա (hy); adenoma (ca); غدومہ (ur); ... Adenomata, Adenoma (tr); Adenomatous, ایڈینوما, ایڈینومیٹوسس, Adenoma, Adenomatosis (ur); Adenome (fr
bronchial adenomas make up about half of all benign lung tumors. they are a diverse group of tumors that arise from mucous ... What are bronchial adenomas?. ANSWER Bronchial adenomas make up about half of all benign lung tumors. They are a diverse group ... A mucous gland adenoma is an example of a true benign bronchial adenoma. ...
Chromophil adenoma definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it ...
... Motoko Sasaki and Yasuni Nakanuma Department of Human Pathology, Kanazawa ... Jean Charles Nault, and Jessica Zucman Rossi, "Molecular Classification of Hepatocellular Adenomas," International Journal of ... Sadhna Dhingra, and M. Isabel Fiel, "Update on the New Classification of Hepatic Adenomas: Clinical, Molecular, and Pathologic ... "Multiple hepatocellular adenomas: a case report," Kanzo, vol. 56, no. 11, pp. 584-595, 2015. View at Publisher · View at Google ...
... Alexandros Iliadis, Triantafyllia Koletsa, Ioannis Kostopoulos, and ... Only very few previously reported cases of pronounced lymphocytic infiltration in parathyroid adenoma can be found in the ...
Moffitt Cancer Center reviews the approaches for treating functioning and nonfunctioning pituitary adenomas. To learn more, ... Nonfunctioning adenomas are often asymptomatic, but may require treatment if they grow large enough to press against a nearby ... Functioning adenomas, on the other hand, produce excessive amounts of hormones that can create imbalances and disrupt various ... Treatment for a pituitary adenoma, or a benign tumor that develops in the pituitary gland, will vary based on the tumors size ...
Growth Hormone-Secreting Pituitary Adenoma, ACTH-Secreting Pituitary Adenoma, Thyrotroph Adenoma, TSH-Secreting Adenoma, ... Pituitary Adenoma, Pituitary Neoplasm, Functionless Pituitary Adenoma, Non-Functioning Pituitary Adenoma, Secretory Pituitary ... Adenoma, Pituitary Macroadenoma, Pituitary Microadenoma, Pituitary Incidentaloma, Prolactinoma, Prolactin-Secreting Pituitary ... Growth Hormone-Secreting Pituitary Adenoma, ACTH-Secreting Pituitary Adenoma, Thyrotroph Adenoma, TSH-Secreting Adenoma, ...
An adenoma (from Greek αδένας, adeno-, "gland" + -ώμα, -oma, "tumor") (/ˌædɪˈnoʊmə/; plural adenomas or adenomata /ˌædɪˈnoʊmɪtə ... Hepatic adenomas are a rare benign tumour of the liver, which may present with hepatomegaly or other symptoms. Breast adenomas ... Bronchial adenomas are adenomas in the bronchi. They may cause carcinoid syndrome, a type of paraneoplastic syndrome. A ... A physicians response to detecting an adenoma in a patient will vary according to the type and location of the adenoma among ...
Pregnancy and liver adenoma management: PALM-study.. van Aalten SM1, Bröker ME, Busschbach JJ, de Koning HJ, de Man RA, ... Hepatocellular adenoma (HCA) in pregnant women requires special considerations because of the risk of hormone induced growth ... The Pregnancy And Liver adenoma Management (PALM) - study is a multicentre prospective study in three cohorts of pregnant ...
Liver cell adenoma: a multicenter analysis of risk factors for rupture and malignancy. Ann Surg Oncol. 2009 Mar. 16(3):640-8. [ ... Pigmented hepatocellular adenomas have a high risk of atypia and malignancy. Mod Pathol. 2015 Sep. 28(9):1265-74. [Medline]. ... Epidemiology of hepatocellular adenoma. The role of oral contraceptive use. JAMA. 1979 Aug 17. 242(7):644-8. [Medline]. ... Drugs & Diseases , Gastroenterology , Hepatocellular Adenoma Q&A Which physical findings are characteristic of hepatocellular ...
  • The number of adenoma specimens was then extended to include polyps exhibiting an increasing degree of epithelial dysplasia. (elsevier.com)
  • Gross total resection was achieved in 82% of pituitary adenomas, 68.8% of meningiomas, and 60% of craniopharyngiomas in anterior extended approach and in 83.3% of chordomas in clival approach, but only in 50% of the tumors in cavernous approach. (surgicalneurologyint.com)
  • Aims: To assess cyclooxygenase-2 (COX-2) expression in sporadic colonic adenomas and to explore the association of COX-2 positivity with adenoma characteristics linked to increased risk of malignant transformation. (elsevier.com)
  • Conclusions: This study associates COX-2 epithelial expression with a number of adenoma characteristics that convey an increased risk of malignant transformation. (elsevier.com)
  • abstract = "Aims: To assess cyclooxygenase-2 (COX-2) expression in sporadic colonic adenomas and to explore the association of COX-2 positivity with adenoma characteristics linked to increased risk of malignant transformation.Methods and results: COX-2 expression and localization were assessed in 64 colorectal adenomas and 35 paired adjacent normal colonic mucosal biopsy specimens. (elsevier.com)
  • Malignant transformation of adenomas of the duodenum is now the leading cause of death in familial adenomatous polyposis (FAP) patients who had a restorative proctocolectomy. (clinicaltrials.gov)
  • Efficiency of Ursodesoxycholic Acid in the Treatment of Duodenal Adenomas in Familial Adenomatous Polyposis Patients. (clinicaltrials.gov)
  • Does a selective cyclooxygenase-2 inhibitor (tiracoxib) induce clinically sufficient suppression of adenomas in patients with familial adenomatous polyposis? (nih.gov)
  • Hepatocellular adenoma displaying a HNF1alpha inactivation in a patient with familial adenomatous polyposis coli. (inserm.fr)
  • Patients with familial adenomatous polyposis coli (FAP) may rarely develop hepatocellular adenoma. (inserm.fr)
  • Design An endoscopy-based case-control study of adenoma was conducted among Caucasians, Japanese and native Hawaiians to test this hypothesis. (bmj.com)
  • The overall diet and consumption of well-done meat cooked by various high-temperature methods were assessed by interview in 1016 patients with a first adenoma and 1355 controls with a normal endoscopy. (bmj.com)
  • Adenoma detection rates also were significantly higher among physicians who described themselves as more thorough than their peers, who said they felt rushed during endoscopy, and who reported having difficulty pacing themselves, accomplishing goals, or managing unforeseen situations. (mdedge.com)
  • Pencil-thin stools, if truly present, would be secondary to large distal adenomas or frank carcinomas. (medscape.com)
  • The aim of this study was to examine the prevalence and characteristics of proximal adenomas in patients with distal adenomas. (nih.gov)
  • We studied 981 subjects with distal adenomas found on the index colonoscopy before randomization in the Polyp Prevention Trial. (nih.gov)
  • (22) , using a case-control study design, found a significant dose-response relationship in males between pack-years of smoking and the location of the adenoma with ORs 3 ranging from 1.3 to 3.5 across levels of smoking exposure for proximal adenomas and OR from 1.3 to 2.0 across exposure levels for distal adenomas. (aacrjournals.org)
  • The etiology of sebaceous adenomas is unclear, but Muir-Torre syndrome is related to a genetic truncating germline mutation. (medscape.com)
  • The etiology of serrated adenomas of the colon is largely unknown, but much recent work has shed light on associated genetic alterations (see Molecular/Genetics, below). (medscape.com)
  • Laboratory studies and epidemiological investigations suggest that vitamin D plays a role in the etiology of colorectal adenomas, possibly through a mechanism mediated by the vitamin D receptor (VDR). (aacrjournals.org)
  • Adenoma, Liver Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • An adenoma is a benign neoplastic growth originating in the glandular epithelial cells. (knowcancer.com)
  • To test this hypothesis, the telomere length of colorectal epithelial cells and cells from connective tissue was determined at the adenoma-carcinoma transition at the cellular level by quantitative fluorescence in situ hybridisation. (bmj.com)
  • In contrast, cells from connective tissue had a similar telomere signal intensity at the carcinoma stage compared with the adenoma, and in turn cells from connective tissue had overall significantly stronger telomere fluorescence signals compared with epithelial cells. (bmj.com)
  • This study tested the hypotheses that well-done meat and cigarette smoking increase the risk of adenoma, the precursor to most colorectal cancers, especially in individuals with rapid CYP1A2 and rapid NAT2 activities. (bmj.com)
  • Two year road to diagnosis of pituitary adenoma. (empowher.com)
  • For patients with about 15 or more colorectal adenomas--especially if no germ-line APC mutation has been identified and the family history is compatible with recessive inheritance--genetic testing of MYH is indicated for diagnosis and calculation of the level of risk in relatives. (nih.gov)
  • Beginning at 1 year after a diagnosis of celiac disease, 29 patients (0.06%) received a diagnosis of small bowel adenocarcinoma vs 45 reference individuals (0.02%), 7 patients received a diagnosis of carcinoids vs 31 reference individuals, and 48 patients received a diagnosis of adenomas vs 50 reference individuals. (onmedica.com)
  • Background: Pheochromocytoma with synchronous ipsilateral adrenal cortical adenoma (PSCA) may present with mixed clinical, biochemical, and radiological features characteristic to each neoplasm subtype.Methods: All patients with a pathological diagnosis of pheochromocytoma were evaluated for an ipsilateral cortical adenoma from 1994 through 2015. (elsevier.com)
  • Results Smoking was associated with an increased risk of adenoma. (bmj.com)
  • Conclusion The data suggest that rapid N -acetylators with high HAA intake may be at increased risk of adenoma. (bmj.com)
  • The results of these studies show that shorter term cigarette smoking exposure is more strongly related to smaller adenomas, suggesting that smoking exposure may have an effect on the earlier development of adenomas. (aacrjournals.org)
  • The aim of the present study was to evaluate the outcome of surveillance and to identify risk factors for the development of adenomas. (bmj.com)
  • This page was last edited on 22 Septemberpituitadio In some patients with CNC, the pituitary gland is characterized by hyperplastic areas with the hyperplasia most likely preceding the formation of GH-producing adenomas. (no-pasaran.mobi)
  • This is a Phase 3, randomized, double-blind, placebo-controlled study to assess the efficacy, and safety of relacorilant to treat hypercortisolism in patients with cortisol-secreting adrenal adenoma or hyperplasia associated with diabetes mellitus/ impaired glucose tolerance and/or uncontrolled systolic hypertension. (clinicaltrials.gov)
  • Colorectal cancer is one of the most common malignancies worldwide and is characterised by sequential morphological changes of the colonic mucosa spanning the adenoma-carcinoma transition coupled with increasing genetic alterations. (bmj.com)
  • Tubular Adenomas are composed of a glandular architecture similar to that of the large intestine mucosa. (pathwaymedicine.org)
  • There was no effect modification of the chemopreventive effect of calcium supplementation in reducing risk of recurrent adenomas or advanced adenomas. (aacrjournals.org)
  • Serum salicylate levels can be detected in individuals not taking aspirin, but the levels may be too low to confer protection from risk of recurrent adenomas. (aacrjournals.org)
  • Additional investigations that characterize the genetic changes in specific subgroups of prevalent and recurrent adenomas associated with smoking exposure are needed. (aacrjournals.org)
  • Pleomorphic adenoma arising from the larynx is very rare. (alliedacademies.org)
  • Pleomorphic adenoma arising from the larynx is very rare, the literature report less than 30 cases [ 5 ]. (alliedacademies.org)
  • Pleomorphic adenoma may occur at any age, but mainly they affect patients in the 4-6 decades with a male to female ration 2:1 [ 6 ]. (alliedacademies.org)
  • A biopsy of the facial mass revealed a pleomorphic adenoma of the parotid gland. (patientcareonline.com)
  • Multiple hepatocellular adenomas associated with long-term a. (lww.com)
  • To assist with future diagnoses, we report about a young boy with multiple hepatocellular adenomas (HAs) induced by long-term use of anabolic androgenic steroids (AAS) for AA and present a related literature review. (lww.com)
  • We measured serum salicylate levels in participants in a randomized controlled trial with calcium supplementation for the prevention of colorectal adenomas. (aacrjournals.org)
  • Greater understanding of the association between smoking and adenoma development enable better detection and prevention of colorectal cancer. (aacrjournals.org)
  • Germ-line mutations in the base-excision-repair gene MYH have been associated with recessive inheritance of multiple colorectal adenomas. (nih.gov)
  • Adenomas were tested for somatic APC mutations. (nih.gov)
  • A substantial proportion of nonpolypoid and polypoid adenomas lack APC mutations, APC methylation or chromosomal loss of the APC locus on chromosome 5q, suggesting the involvement of other Wnt-pathway genes. (biomedcentral.com)
  • In addition, genetic mutations in BRAF, RET, KRAS, and genetic rearrangement of the PAX8-PPAR gene are strongly associated with the development of a thyroid adenoma. (statpearls.com)
  • Functional adenomas are most commonly the result of a monoclonal expansion of thyroid cells, due to activating mutations in the TSH-receptor gene and less commonly in adenylate cyclase stimulating G alpha protein gene. (statpearls.com)
  • The difference between POMC gene expression in silent 1 and silent 2 and 3 adenomas suggests that different mechanisms are responsible for the lack of endocrine activity. (nih.gov)
  • Endoscopists who described themselves as "compulsive" and "thorough" had significantly higher rates of adenoma detection, according to results from a self-reported survey of 117 physician endoscopists. (mdedge.com)
  • Financial incentives, malpractice concerns, and perceptions of adenoma detection rate as a quality metric were not associated with endoscopists' detection rates in the survey. (mdedge.com)
  • Adenoma detection rates vary widely among physicians - up to threefold in some studies. (mdedge.com)
  • Other potential variables include personality traits and endoscopists' knowledge and views on the importance of adenoma detection rates. (mdedge.com)
  • To examine the roles of these factors in adenoma detection rates, Dr. Ezaz and coinvestigators used electronic health records data from four health systems in Boston, Pittsburgh, North Carolina, and Seattle. (mdedge.com)
  • We found no significant association between adenoma detection rate and financial incentives, malpractice concerns, or physicians' perceptions of adenoma detection rate as a quality metric," the researchers wrote. (mdedge.com)
  • In contrast, endoscopists who described themselves as either much or somewhat more compulsive than their peers had significantly higher median adjusted rates of adenoma detection than did endoscopists who described themselves as about the same or somewhat less compulsive than others. (mdedge.com)