A benign epithelial tumor with a glandular organization.
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.
A benign epithelial tumor of the LIVER.
A benign tumor of the anterior pituitary in which the cells do not stain with acidic or basic dyes.
A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.
A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.
A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)
A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.
A small tumor of the anterior lobe of the pituitary gland whose cells stain with basic dyes. It may give rise to excessive secretion of ACTH, resulting in CUSHING SYNDROME. (Dorland, 27th ed)
Tumors or cancers of the ADRENAL CORTEX.
A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.
A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
Tumors or cancer of the SALIVARY GLANDS.
Tumors or cancer of the COLON.
Tumors or cancer of the INTESTINES.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Tumors or cancer of the ADRENAL GLANDS.
A disease of the PITUITARY GLAND characterized by the excess amount of ADRENOCORTICOTROPIC HORMONE secreted. This leads to hypersecretion of cortisol (HYDROCORTISONE) by the ADRENAL GLANDS resulting in CUSHING SYNDROME.
Tumors or cancer of the PAROTID GLAND.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.
An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).
Tumors or cancer of the DUODENUM.
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
A malignant epithelial tumor with a glandular organization.
A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
Tumors or cancer of the THYROID GLAND.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND.
Endoscopic examination, therapy or surgery of the sigmoid flexure.
A mass of histologically normal tissue present in an abnormal location.
Tumors or cancer of the RECTUM.
The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.
A 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
Hormones secreted by the PITUITARY GLAND including those from the anterior lobe (adenohypophysis), the posterior lobe (neurohypophysis), and the ill-defined intermediate lobe. Structurally, they include small peptides, proteins, and glycoproteins. They are under the regulation of neural signals (NEUROTRANSMITTERS) or neuroendocrine signals (HYPOTHALAMIC HORMONES) from the hypothalamus as well as feedback from their targets such as ADRENAL CORTEX HORMONES; ANDROGENS; ESTROGENS.
A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.
Excision of one or more of the parathyroid glands.
Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
A benign tumor of the intrahepatic bile ducts.
A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.
The segment of LARGE INTESTINE between TRANSVERSE COLON and the SIGMOID COLON.

Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. (1/4752)

Overexpression of cell surface glycoproteins of the CD44 family is an early event in the colorectal adenoma-carcinoma sequence. This suggests a link with disruption of APC tumor suppressor protein-mediated regulation of beta-catenin/Tcf-4 signaling, which is crucial in initiating tumorigenesis. To explore this hypothesis, we analyzed CD44 expression in the intestinal mucosa of mice and humans with genetic defects in either APC or Tcf-4, leading to constitutive activation or blockade of the beta-catenin/Tcf-4 pathway, respectively. We show that CD44 expression in the non-neoplastic intestinal mucosa of Apc mutant mice is confined to the crypt epithelium but that CD44 is strongly overexpressed in adenomas as well as in invasive carcinomas. This overexpression includes the standard part of the CD44 (CD44s) as well as variant exons (CD44v). Interestingly, deregulated CD44 expression is already present in aberrant crypt foci with dysplasia (ACFs), the earliest detectable lesions of colorectal neoplasia. Like ACFs of Apc-mutant mice, ACFs of familial adenomatous polyposis (FAP) patients also overexpress CD44. In sharp contrast, Tcf-4 mutant mice show a complete absence of CD44 in the epithelium of the small intestine. This loss of CD44 concurs with loss of stem cell characteristics, shared with adenoma cells. Our results indicate that CD44 expression is part of a genetic program controlled by the beta-catenin/Tcf-4 signaling pathway and suggest a role for CD44 in the generation and turnover of epithelial cells.  (+info)

MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene-environment interactions in colorectal tumorigenesis. (2/4752)

Our studies on interactions of a folate-metabolizing gene polymorphism and dietary intake in colorectal tumorigenesis demonstrate the potential importance of studying interactions between genotype and environmental exposure in relation to cancer risk. We observed an inverse association of a polymorphism (667C --> T, ala --> val) in the methylenetetrahydrofolate reductase (MTHFR) gene with colorectal cancer but not with colorectal adenomas. The inverse association of methionine and adverse association of alcohol with colorectal cancer were stronger among val/val individuals. These interactions were not present in studies of colorectal adenomas. Our studies illustrate that studying gene-environment interactions in relation to cancer can be of importance in clarifying cancer etiology as well as pointing to preventive dietary modifications.  (+info)

Expression of relaxin-like factor is down-regulated in human testicular Leydig cell neoplasia. (3/4752)

In addition to their role in steroidogenesis in the male, testicular Leydig cells constitutively express large amounts of the peptide relaxin-like factor (RLF), also known as Ley-IL. The Leydig cell-derived RLF belongs to the insulin-like superfamily, which also includes relaxin, insulin and the insulin-like growth factors, and within the testis is a specific marker of Leydig cells. Little information is available either on the regulation of gene expression or on the function of this Leydig cell-derived peptide. In the present study we have investigated the expression pattern of human RLF in patients with rare Leydig cell hyperplasia and adenoma. The expression of both mRNA and protein appear to be decreased in hyperplastic Leydig cells, whereas in the Leydig cell adenomas studied, large central areas of the adenoma were devoid of RLF mRNA and protein. Only Leydig cells located at the periphery of the adenoma displayed expression of RLF, with full agreement between in-situ hybridization and immunohistochemistry. It thus appears that the expression of the RLF gene and its products are down-regulated in Leydig cell hyperplasia and adenoma, consistent with a concomitant dedifferentiation of these cells.  (+info)

Effect of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis and aberrant crypt foci. (4/4752)

We have previously reported that the retinoids, 4-(hydroxyphenyl)retinamide (4-HPR) and 9-cis-retinoic acid (RA) prevented azoxymethane (AOM)-induced colon tumors and along with 2-(carboxyphenyl)retinamide (2-CPR) prevented aberrant crypt foci (ACF). In this study, we evaluated the effect of 2-CPR on AOM-induced colon tumors and the effect of the three retinoids on apoptosis and cell proliferation. Male F344 rats were administrated 15 mg/kg AOM at weeks 7 and 8 of age. 2-CPR (315 mg/kg) was administered in the diet starting either 1 week before or at week 12 after the first dose of AOM. The rats continued to receive the 2-CPR until killed at week 46. Unlike the demonstrated prevention of colon cancer by the other two retinoids, both dosing schedules of 2-CPR resulted in an approximate doubling of the yield of colon tumors. In adenomas, 2-CPR, 4-HPR and 9-cis-RA were equally effective in reducing mitotic activity, while only 4-HPR and 9-cis-RA but not 2-CPR enhanced apoptosis. When administered for only the 6 days prior to killing 4-HPR but not 2-CPR decreased the Mitotic Index and increased the Apoptotic Index in adenomas. In non-involved crypts, chronic exposure to 4-HPR and 9-cis-RA in contrast to 2-CPR reduced the Mitotic Index and enhanced the Apoptotic Index. In concurrence with our previous study, both 2-CPR and 4-HPR were very potent in preventing ACF when administered in the diet starting 1 week before the first dose of AOM and continuing for the 5 weeks of the study. Hence, unlike the other two retinoids, 2-CPR, although very potent in preventing ACF, enhanced rather than prevented AOM-induced colon cancer. Furthermore, our results suggest that the effect of 2-CPR on tumor yield is different from 4-HPR and 9-cis-RA because, unlike them, it does not enhance apoptosis.  (+info)

Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell. (5/4752)

Human methylguanine-DNA methyltransferase (MGMT) transgenic mice expressing high levels of O6-alkylguanine-DNA alkyltransferase (AGT) in lung were crossbred to A/J mice that are susceptible to pulmonary adenoma to study the impact of O6-methylguanine (O6mG)-DNA adduct repair on NNK-induced lung tumorigenesis. Expression of the chimeric human MGMT transgene in lung was identified by northern and western blot analysis, immunohistochemistry assay and enzymatic assay. AGT activity was 17.6 +/- 3.2 versus 1.2 +/- 0.4 fmol/microg DNA in lung of MGMT transgenic mice compared with non-transgenic mice. Immunohistochemical staining with anti-human AGT antibody showed that human AGT was expressed throughout the lung. However, some epithelial cells of bronchi and alveoli did not stain for human AGT, suggesting that the human MGMT transgene expression was heterogeneous. After 100 mg/kg NNK i.p. injection in MGMT transgenic mice, lung AGT activity remained much higher and levels of lung O6mG-DNA adducts in MGMT transgenic mice were lower than those of non-transgenic mice. In the tumorigenesis study, mice received 100 mg/kg NNK at 6 weeks of age and were killed 44 weeks later. Ten of 17 MGMT transgenic mice compared with 16 of 17 non-transgenic mice had lung tumors, P < 0.05. MGMT transgenic mice had lower multiplicity and smaller sized lung tumors than non-transgenic mice. Moreover, a reduction in the frequency of K-ras mutations in lung tumors was found in MGMT transgenic mice (6.7 versus 50% in non-transgenic mice). These results indicate that high levels of AGT expressed in mouse lung reduce lung tissue susceptibility to NNK-induced tumorigenesis due to increased repair capacity for O6mG, subsequently, decreased mutational activation of K-ras oncogene. Heterogeneity in the level of AGT expressed in different lung cell populations or other forms of carcinogenic DNA damage caused by NNK may explain the residual incidence of lung tumors in MGMT transgenic mice.  (+info)

Possible carcinogenic effects of X-rays in a transgenerational study with CBA mice. (6/4752)

A lifetime experiment using 4279 CBA/J mice was carried out to investigate whether the pre-conceptual exposure of sperm cells to X-ray radiation or urethane would result in an increased cancer risk in the untreated progeny, and/or increased susceptibility to cancer following exposure to a promoting agent. The study consisted of four main groups, namely a control group (saline), a urethane group (1 mg/g body wt) and two X-ray radiation groups (1 Gy, 2 Gy). At 1, 3 and 9 weeks after treatment, the males of these four parental groups were mated with untreated virgin females. The offspring of each parental group was divided into two subgroups: one received s.c. urethane (0.1 mg/g body wt once) as a promoter, the other saline, at the age of 6 weeks. All animals were evaluated for the occurrence of tumours. K-ras oncogene and p53 tumour suppressor gene mutations were investigated in frozen lung tumour samples. The female offspring of male parents exposed to X-rays 1 week before their mating showed a trend towards a higher tumour incidence of the haematopoietic system than the F1 controls. In addition, a higher percentage of bronchioloalveolar adenocarcinomas in male offspring born to irradiated paternals mated 1 week after X-ray treatment points to a plausible increased sensitivity of post-meiotic germ cell stages towards transgenerational carcinogenic effects. On the other hand, no increased tumour incidence and malignancy were observed in the offspring born to irradiated paternals mated 3 and 9 weeks after X-ray treatment. Paternal urethane treatment 1, 3 and 9 weeks prior to conception did not result in significantly altered incidence or malignancy of tumours of the lung, liver and haematopoietic tissue in the offspring. K-ras mutations increased during tumour progression from bronchioloalveolar hyperplasia to adenoma. Codon 61 K-ras mutations were more frequent in lung tumours of urethane-promoted progeny from irradiated parents than from control parents. P53 mutations were absent from these lung alterations.  (+info)

Epithelial thyroid tumors in cows. (7/4752)

From 1964 to 1973, 370 tumors were collected from cows of unknown age. Ten (2.7%) of these were primary thyroid tumors. Three were malignant. The benign tumors were solitary encapsulated adenomas in the parenchyma with more or less defined trabeculae, tubular, and microfollicular pattern. One of the malignant tumors was a cystic papillary adenocarcinoma, and two were small cell carcinomas consisting of small, sometimes binuclear, pleomorphic cells.  (+info)

The elevated serum alkaline phosphatase--the chase that led to two endocrinopathies and one possible unifying diagnosis. (8/4752)

A 39-year-old Chinese man with hypertension being evaluated for elevated serum alkaline phosphatase (SAP) levels was found to have an incidental right adrenal mass. The radiological features were characteristic of a large adrenal myelolipoma. This mass was resected and the diagnosis confirmed pathologically. His blood pressure normalised after removal of the myelolipoma, suggesting that the frequently observed association between myelolipomas and hypertension may not be entirely coincidental. Persistent elevation of the SAP levels and the discovery of hypercalcaemia after surgery led to further investigations which confirmed primary hyperparathyroidism due to a parathyroid adenoma. The patient's serum biochemistry normalised after removal of the adenoma. The association of adrenal myelolipoma with primary hyperparathyroidism has been reported in the literature only once previously. Although unconfirmed by genetic studies this association may possibly represent an unusual variation of the multiple endocrine neoplasia type 1 syndrome.  (+info)

In this large prospective study, higher intake of marine n-3 fatty acids was not associated with risk of distal colorectal adenoma. In addition, no significant associations were observed between this dietary variable and risks of small adenoma, distal colon adenoma, and rectal adenoma, although a nonsignificant, suggestive, inverse association was noted for large adenoma. Similarly, we found no significant associations between n-3/n-6 ratio and risks of distal colorectal adenoma.. We did find a suggestively decreased risk of large adenoma associated with higher dietary marine n-3 fatty acid intake (RR, 0.74; 95% CI, 0.54-1.01). Interestingly, we also noted that high n-3 intake was associated with a nonsignificant increase in risk of small adenoma. We thus conducted a post hoc analysis and found that among women with a diagnosis of adenoma, those with high dietary intake of marine n-3 fatty acids had a 46% lower odds of having a large adenoma versus a small adenoma. In combination, these results ...
Pituitary adenomas are tumors that occur in the pituitary gland. Pituitary adenomas are generally divided into three categories dependent upon their biological functioning: benign adenoma, invasive adenoma, and carcinomas. Most adenomas are benign, approximately 35% are invasive and just 0.1% to 0.2 are carcinomas. Pituitary adenomas represent from 10% to 25% of all intracranial neoplasms and the estimated prevalence rate in the general population is approximately 17%. Non-invasive and non-secreting pituitary adenomas are considered to be benign in the literal as well as the clinical sense; however a recent meta-analysis (Fernández-Balsells, et al. 2011) of available research has shown there are to date scant studies - of poor quality - to either support or refute this assumption. Adenomas which exceed 10 millimetres (0.39 in) in size are defined as macroadenomas, with those smaller than 10 mm referred to as microadenomas. Most pituitary adenomas are microadenomas, and have an estimated ...
We report for the first time that the fraction of ALDH1A1-expressing putative stem-like cells in colorectal adenoma epithelium is correlated among synchronous adenomas in individual patients, and that the presence of a larger subpopulation of these adenoma stem-like cells is associated with increased risk for the patient to have a metachronous adenoma at another location in the large bowel at follow-up. Of note, the association between percentage of ALDH1A1-expressing adenoma cells and risk of a metachronous adenoma is independent of both the adenoma and clinical characteristics previously reported to be associated with increased risk (i.e., villous architecture, high-grade dysplasia, and size of the baseline adenoma, and age and male sex of the study subjects). Our findings raise the possibility that a larger stem-like cell subpopulation in a baseline adenoma may serve as a quantifiable biomarker for the propensity of a patient to develop a subsequent colorectal neoplasm. If corroborated, this ...
Background: Sporadic adenoma formation found on surveillance colonoscopies in patients with inflammatory bowel disease (IBD) represents a significant risk for cancer. Certain racial groups like African Americans (AA) are at increased risk of developing colorectal cancer (CRC), but there is conflicting literature on differences in sporadic adenoma formation. Some data suggests AA are at increased risk for large adenomas, more proximal lesions, and increased prevalence. These data, however, are studying the general population and to our knowledge no study has looked at differences in adenoma formation by race in IBD patients. The present retrospective study analyzes the prevalence of adenomas in IBD patients. Methods: All IBD patients who received a surveillance colonoscopy within the past year were included in the present study. Sporadic adenomas included serrated, tubular, villous, and tubulovillous adenoma formation. A database was created using Microsoft Excel and identifying information was
TY - JOUR. T1 - Both Transforming Growth Factor-β and Substrate Release Are Inducers of Apoptosis in a Human Colon Adenoma Cell Line. AU - Cheng Ya Wang, Ya Wang. AU - Eshleman, J. R.. AU - Willson, J. K V. AU - Markowitz, S.. PY - 1995/11/1. Y1 - 1995/11/1. N2 - VACO-330, a nontransfonned cell line established from a human colon adenoma, undergoes spontaneous apoptosis and shedding of cells into the culture medium. Shed cells were shown to be apoptotic, both by nuclear morphology and by generation of a typical laddered pattern of degraded DNA. Quantitation of DNA released into the medium, compared with the amount retained on the plate, demonstrated that 6.2 ± 1.1% of the total cell mass underwent apoptotic death daily. The addition of transforming growth factor β (20 ng/ml) accelerated this spontaneous apoptotic rate 3.2-fold. Moreover, apoptosis could be rapidly induced in up to 45% of the VACO-330 cells by using brief exposure to a calcium chelating medium to release the cells from the ...
A small study suggests that serrated adenoma may be a form of familial adenomatous polyposis (FAP) and not a separate type of colorectal cancer.. Three serrated adenomas were found separately in three out of 11 Japanese patients from three families with FAP. Colorectal polyps numbered ,100 in each of the three, and all serrated adenomas were found in the rectum. All three patients with serrated adenomas had mutations in the adenomatous polyposis coli (APC) gene-two proximal to the site of the gene, at codon 161, 332 and the third at the most distal site, codon 1556. Mutations in the other patients were located between codons 554 and 1324.. The rate of occurrence of serrated adenoma in the study was 30 times that in the general population so APC mutation may influence pathogenesis of serrated adenoma. The genetic results are compatible with a recent report describing colonic polyposis of ,100 polyps as attenuated FAP, so serrated adenoma may actually be a phenotype of FAP.. All 11 patients had a ...
Background & Objectives: Tubular adenomas are rare benign epithelial tumours of breast affecting predominantly females of child bearing age group. Till now, very small number of cases have been reported in the literature. Present study was carried out to evaluate the clinico-pathological features of tubular adenoma cases diagnosed during three years study period along with discussion of possible differential diagnoses. Methods: Overall, 346 female breast biopsies were diagnosed as benign lesions in three years (2010-2012), of which 10 cases of tubular adenomas were identified. Available clinical, radiological and cytological data of these cases were analysed retrospectively in detail. Result: Tubular adenomas were identified from 16 to 48 years of age with a predilection to younger age group (60% within 30 years). Most of the tubular adenomas were small and circumscribed mimicking fibroadenoma in almost all the cases. Diagnosis of tubular adenoma in each case was possible only after histological
BACKGROUND/AIMS: Evidence for the effect of dietary factors on colorectal carcinogenesis is yet inconsistent. Few studies have been conducted to investigate whether dietary factors were associated with the development of colorectal adenoma-carcinoma sequence in Korea. We evaluated the relationship between the intake of vegetables and fruits and the degree of dysplasia of the colorectal adenoma and cancer. METHODS: For this study, 539 cases with histopathologically confirmed incidental colorectal adenoma, 162 cases with colorectal cancer and 2,576 controls were collected from Our Lady of Mercy Hospital, The Catholic University of Korea during 1994-1999. Informations on demographic characteristics, life style habits and dietary intake were obtained by interviewed questionnaire before the colonoscopy. Adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated by using polytomous logistic regression model. RESULTS: In female, the high intake of raw green and yellow vegetables were found to be
Supplementation with fibre as ispaghula husk may have adverse effects on colorectal adenoma recurrence, especially in patients with high dietary calcium intake. Calcium supplementation was associated with a modest but not significant reduction in the risk of adenoma recurrence.
Pituitary Cancer. Pituitary tumors are unusual growths found in the pituitary organ which makes hormones that influence development and the functions of different glands in the body.. The pituitary organ is a pea-sized, reddish dim organ in the focal point of the brain, just above and behind the nose.. Pituitary carcinomas happen in both sexes, usually by the third or fourth decades of life. These tumors are very basic with 25% of individuals having small pituitary tumors on autopsy however most are sans symptom and the vast larger part of pituitary adenomas go undiagnosed all through life.. Types of Pituitary Tumors. The types are named after the types of hormones the pituitary makes and incorporate prolactin-delivering adenomas, somatotrophin-secreting adenomas, corticotrophin-secreting adenomas, gonadotrophin-secreting adenomas, thyrotrophin-secreting adenomas, invalid cell adenomas, and adenomas of the blended cell sort. Another kind of pituitary cancer shows up as substantial hands, feet ...
Medical information, Thyroid adenoma. Definition of Thyroid adenoma, symptoms of Thyroid adenoma, treatment of Thyroid adenoma, and prevention of Thyroid adenoma. Exams and Tests Thyroid adenoma.
Author(s): Meyskens, Frank L, Jr; McLaren, Christine E; Pelot, Daniel; Fujikawa-Brooks, Sharon; Carpenter, Philip M; Hawk, Ernest; Kelloff, Gary; Lawson, Michael J; Kidao, Jayashri; McCracken, John; Albers, C Gregory; Ahnen, Dennis J; Turgeon, D Kim; Goldschmid, Steven; Lance, Peter; Hagedorn, Curt H; Gillen, Daniel L; Gerner, Eugene W | Abstract: Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing adenomas with little additional toxicities, suggesting a strategy to improve risk to benefit ratios for preventing recurrent adenomas. Three hundred seventy-five patients with history of resected (> or =3 mm) adenomas were randomly assigned to receive oral difluoromethylornithine (DFMO) 500 mg and sulindac 150 mg once daily or matched placebos for 36 months, stratified by use of low-dose aspirin (81 mg) at baseline and clinical site. Follow-up colonoscopy was done 3 years after randomization or off-study. Colorectal adenoma recurrence was
TY - JOUR. T1 - Increased risk of adenomas in individuals with a family history of colorectal cancer. T2 - results of a meta-analysis. AU - Wilschut, Janneke A. AU - Habbema, J Dik F. AU - Ramsey, Scott D. AU - Boer, Rob. AU - Looman, Caspar W N. AU - van Ballegooijen, Marjolein. PY - 2010/12. Y1 - 2010/12. N2 - OBJECTIVE: It is unclear to what extent the increased risk of colorectal cancer in individuals with a family history of colorectal cancer and no known genetic disorders is associated with a higher adenoma prevalence. Our aim is to estimate the relative difference in adenoma prevalence and its age-pattern in individuals with a family history of colorectal cancer compared to those without.METHODS: We performed a literature search to identify colonoscopy studies reporting the adenoma prevalence by age. Using multilevel logistic regression, we examined how the adenoma prevalence by age differed between individuals with and without a family history of colorectal cancer. We excluded members of ...
The authors report a clinical case of alveolar adenoma presenting as a solitary pulmonary nodule which was positive to PET and deeply located in the lung. Few cases of alveolar adenomas have been reported in literature; these lesions are considered pulmonary neoplasms with benign behaviour, usually presenting as a peripheral or subpleural coin lesion; the PET activities of such neoplasms were unknown. The present clinical case was singular for the deep location of the nodule and its tight adhesion to left inferior pulmonary vein requiring a lobectomy. In addition, alveolar adenoma PET behaviour has been reported as light positivity.
Introduction Down-regulation of E-cadherin (CDH1) and epithelial-mesenchymal transition (EMT) are considered critical events for invasion and metastasis of colorectal carcinoma. Here we tested whether the important regulators of E-cadherin expression SNAI1 and TWIST1 are already detectable in human colorectal adenomas. Methods RNA was extracted from a set of randomly selected formalin-fixed and paraffin-embedded (FFPE) colorectal adenomas (n = 41) and normal colon mucosa (n = 10). Subsequently mRNA expression of CDH1, CDH2, SNAI1 and TWIST1 was analysed by quantitative RT-PCR analysis. CDH1 as well as SNAI1 protein expression were assessed by immunohistochemistry (IHC). Results SNAI1 mRNA was expressed in 78% (n = 32/41), TWIST1 mRNA in 41% (n = 17/41) and CDH2 mRNA in 41% (n = 17/41) of the colorectal adenoma tissue, while normal colon mucosa was negative for these transcription factors. We found a significant correlation between reduced CDH1 and the presence of SNAI1 mRNA expression and for
BACKGROUND: Colorectal cancer incidence is rapidly rising in many Asian countries, with rates approaching those of Western countries. This study aimed to evaluate the prevalence and trends of colorectal adenomas by age, sex, and risk strata in asymptomatic Koreans. METHODS: Cross-sectional study of 19,372 consecutive participants aged 20 to 79 years undergoing screening colonoscopy at the Center for Health Promotion of the Samsung Medical Center in Korea from January 2006 to June 2009. RESULTS: Among participants at average risk, those without a history of colorectal polyps or a family history of colorectal cancer, the prevalence of colorectal adenomas and advanced adenomas were 34.5% and 3.1%, respectively, in men and 20.0% and 1.6%, respectively, in women. The prevalence of adenomas increased with age in both men and women, with a more marked increase for advanced adenoma. Participants with a family history of colorectal cancer or with a history of colorectal polyps had significantly higher ...
TY - JOUR. T1 - Estimation of colorectal adenoma recurrence with dependent censoring. AU - Hsu, Chiu Hsieh. AU - Long, Qi. AU - Alberts, David S.. PY - 2009. Y1 - 2009. N2 - Background. Due to early colonoscopy for some participants, interval-censored observations can be introduced into the data of a colorectal polyp prevention trial. The censoring could be dependent of risk of recurrence if the reasons of having early colonoscopy are associated with recurrence. This can complicate estimation of the recurrence rate. Methods. We propose to use midpoint imputation to convert interval-censored data problems to right censored data problems. To adjust for potential dependent censoring, we use information from auxiliary variables to define risk groups to perform the weighted Kaplan-Meier estimation to the midpoint imputed data. The risk groups are defined using two risk scores derived from two working proportional hazards models with the auxiliary variables as the covariates. One is for the recurrence ...
Background: Use of multivitamins may reduce the risk of colorectal adenoma, but the duration of use needed is unclear. Methods: We prospectively examined years of multivitamin use and risk of colorectal adenoma among 43 641 women who had a first endoscopy between 1991 and 2007 in the Nurses Health Study II. Use of multivitamins was assessed through biennial questionnaires since 1989. Results: We documented 2277 colorectal adenoma cases. Reporting multivitamin use at any time during the study period compared with never reporting its use was associated with a reduced risk of adenoma (multivariable relative risk (RR)=0.86, 95% confidence interval (CI): 0.76-0.97). There was no clear trend with duration of multivitamin use: years of use compared with never use, ⩽4 years (RR=0.84, 95% CI: 0.74-0.96), 5-9 years (RR=0.89, 95% CI: 0.77, 1.02), 10-14 years (RR=0.86, 95% CI: 0.74, 1.01), 15-19 years (RR=0.85, 95% CI: 0.70, 1.02), and 20-26 years (RR=0.80, 95% CI: 0.64, 1.01); (P trend=0.87). The ...
Fingerprint Dive into the research topics of Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines. Together they form a unique fingerprint. ...
TY - JOUR. T1 - Increased risk of colorectal adenomas in Italian subjects carrying the p53 PIN3 A2-Pro72 haplotype. AU - Perfumo, Chiara. AU - Bonelli, Luigina. AU - Menichini, Paola. AU - Inga, Alberto. AU - Gismondi, Viviana. AU - Ciferri, Enrico. AU - Percivale, Pierluigi. AU - Bianchi Scarrà, Giovanna. AU - Nasti, Sabina. AU - Fronza, Gilberto. AU - Varesco, Liliana. PY - 2007/4. Y1 - 2007/4. N2 - Background: Few reports have investigated the association of two p53 polymorphisms (Arg72Pro and PIN3-A2) with colorectal cancer (CRC) risk, and no previous study has analyzed their role as susceptibility alleles for colorectal adenoma. Aim: To explore the impact of the p53 PIN3-Arg72Pro haplotype on colorectal adenoma formation and progression to cancer. Methods: One hundred and eighty-four colorectal tumor patients (124 with adenomas and 60 with adenocarcinoma) and 188 controls (42 subjects with a clean colon, 54 hospital controls and 92 blood donors) from the Italian population were tested for ...
Background: Colorectal adenomas are precursor lesions of colorectal cancer. About 5% of colorectal adenomas are estimated to progress to colorectal cancer (CRC). The currently used histo-pathological characteristics to identify adenomas at risk of malignant progression, i.e. scoring of size ≥ 10mm, villous component or high grade dysplasia, are not sufficiently sensitive and specific and prone to inter-observer variability. Integrating molecular markers reflecting the underlying biology of CRC into the current classification system is expected to better characterize adenomas at high-risk of progression.. Aim: Here we compared the prevalence of genetic changes, in particular DNA copy number changes, between advanced and non-advanced adenomas.. Methods: Formalin-fixed paraffin-embedded tissue samples from 121 patients (mean age 65.4±11.6, 52.9% male) with colorectal adenomas (63 non-advanced adenomas and 58 advanced adenomas) were retrospectively collected from the archives of the department of ...
TY - JOUR. T1 - Frequent nuclear accumulation of β-catenin in pituitary adenoma. AU - Semba, Shuho. AU - Han, Shuang Yin. AU - Ikeda, Hidetoshi. AU - Horii, Akira. PY - 2001/1/1. Y1 - 2001/1/1. N2 - BACKGROUND. β-catenin (CTNNB1) is known to be a member of the cadherin-catenin superfamily and to function in cell-cell adhesion. However, it also has been reported that CTNNB1 plays an important role in carcinogenesis. In the current study, the authors observed expression of the CTNNB1 protein in primary pituitary adenomas to investigate the role of CTNNB1 in the development of pituitary adenomas. METHODS. A total of 37 pituitary adenomas were analyzed. Expression of CTNNB1 and the cell proliferation marker Ki-67 were observed immunohistochemically. In addition, the authors performed direct sequencing to detect somatic mutations of exon 3 of the CTNNB1 gene. RESULTS. Twenty-one of 37 pituitary adenomas (57%) demonstrated abnormal nuclear accumulation of CTNNB1. It is interesting to note that ...
Serrated adenomas form a distinct subtype of colorectal pre-malignant lesions that may progress to malignancy along a different molecular pathway than the conventional adenoma-carcinoma pathway. Previous studies have hypothesised that BRAF mutation and promoter hypermethylation plays a role, but the evidence for this is not robust. We aimed to carry out a whole-genome loss of heterozygosity analysis, followed by targeted promoter methylation and expression analysis to identify potential pathways in serrated adenomas. An initial panel of 9 sessile serrated adenomas (SSA) and one TSA were analysed using Illumina Goldengate HumanLinkage panel arrays to ascertain regions of loss of heterozygosity. This was verified via molecular inversion probe analysis and microsatellite analysis of a further 32 samples. Methylation analysis of genes of interest was carried out using methylation specific PCR (verified by pyrosequencing) and immunohistochemistry used to correlate loss of expression of genes of interest. All
The mechanism of prostate adenoma development is not yet fully defined. Despite the popular belief that prostate adenoma is associated with chronic prostatitis, there is no data that would confirm the link between these two diseases. The researchers found no Association between the development of prostate adenoma and alcohol and tobacco use, sexual orientation, sexual activity, and venereal and inflammatory diseases.. There is a pronounced dependence of the frequency of prostate adenoma on the age of the patient. Scientists believe that prostate adenoma develops as a result of hormonal disorders in men with the onset of andropause (male menopause). This theory is supported by the fact that prostate adenoma never affects men who are castrated before puberty and, extremely rarely, men who are castrated after puberty.. There are two groups of symptoms of prostate adenoma:. ...
In this large cross-sectional study of asymptomatic men and women attending a health screening program, among those at average risk of colorectal adenoma we found that 34.5% of men and 20.0% of women had prevalent colorectal adenomas, and 3.1% of men and 1.6% of women had prevalent advanced adenomas. The prevalence of colorectal adenomas and of advanced adenomas increased significantly with age in both men and women, particularly for multiple, larger, and advanced adenomas. The prevalence of adenomas increased annually over the study period in both men and women.. Our estimates of the prevalence of colorectal adenomas are consistent with previous studies based on more selected and smaller screening samples (7, 11). In one study, the prevalence of colorectal adenomas among average risk asymptomatic Koreans 50 years of age or older were 39.9% and 23.0% among men and women, respectively (7), whereas in another study, the prevalence among Korean men 40 to 69 years of age was 36.3% (11). These ...
BACKGROUND & AIMS Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α), two important inflammatory cytokines, have been inconsistently associated with risk of colon neoplasia in epidemiological studies. However, research to date has not adequately assessed whether race-specific differences may exist in associations between biomarkers and genetic variants of these cytokines and colorectal adenoma - the precursor lesions of colorectal cancer. We sought to determine whether circulating levels of IL-6 and TNF-α, or genetic polymorphisms in IL-6and TNF-α were associated with colon adenoma and if so, whether that association differed by race. METHODS We analyzed the associations of circulating levels and single nucleotide polymorphisms (SNPs) of IL-6 and TNF-α with risk of colon adenomas in a colonoscopy -based case-control study of 401 incident adenoma cases and 1,050 controls. We used multivariate unconditional logistic regression models to estimate the odds ratios (OR) and 95% confidence
TY - JOUR. T1 - Risk stratification of individuals with low-risk colorectal adenomas using clinical characteristics. T2 - A pooled analysis. AU - Gupta, Samir. AU - Jacobs, Elizabeth T.. AU - Baron, John A.. AU - Lieberman, David. AU - Murphy, Gwen. AU - Ladabaum, Uri. AU - Cross, Amanda J.. AU - Jover, Rodrigo. AU - Liu, Lin. AU - Martinez, Maria Elena. PY - 2017/3/1. Y1 - 2017/3/1. N2 - Objective For individuals with 1-2 small (,1 cm) low-risk colorectal adenomas, international guidelines range from no surveillance to offering surveillance colonoscopy in 5-10 years. We hypothesised that the risks for metachronous advanced neoplasia (AN) among patients with low-risk adenomas differ based on clinical factors distinct from those currently used. Design We pooled data from seven prospective studies to assess the risk of metachronous AN. Two groups with 1-2 small adenomas were defined based on guidelines from the UK (n=4516) or the European Union (EU)/US (n=2477). Results Absolute risk of ...
TY - JOUR. T1 - CT and ultrasound features of metanephric adenoma in adults with pathologic correlation. AU - Fielding, Julia R.. AU - Visweswaran, Aparna. AU - Silverman, Stuart G.. AU - Granter, Scott R.. AU - Renshaw, Andrew A.. PY - 1999/5/1. Y1 - 1999/5/1. N2 - Purpose: The purpose of this work was to correlate the CT, ultrasound, and pathologic features of metanephric adenoma, a rare benign renal tumor in adults. Method: Retrospective review of medical records (1990-1997) revealed three adult female patients who had both preoperative imaging and nephrectomy with pathologic diagnosis of metanephric adenoma performed at our institution. CT (n = 3) and ultrasound (n = 2) features were reviewed in consensus by two radiologists and correlated with pathologic findings. Results: In all three cases, the metanephric adenoma was of increased attenuation relative to adjacent renal parenchyma on unenhanced CT scans. No septa or calcifications were seen. Ultrasound images showed both tumors to be ...
Obesity is a known risk factor for colon cancer and higher body mass index (BMI) has been associated with colorectal adenomas, which are precursor lesions to most colorectal cancers. Polymorphisms in the fat-mass and obesity-associated (FTO) gene have been associated with BMI and larger effects in older versus younger children have been reported. However, no studies have examined associations between FTO polymorphisms, BMI throughout adulthood and colorectal adenomas. Therefore, we evaluated associations between FTO polymorphisms (rs1421085, rs17817449, rs8050136, rs9939609, rs8044769), adult BMI (at recruitment, 50s, 40s, 30s, 20s age decades) and colorectal adenomas in 759 Caucasians and 469 African-Americans. We found that the highest versus the lowest BMI tertile at recruitment [odds ratio (OR) = 1.82; 95% confidence interval (CI): 1.07-2.16] and in the 30s (OR = 1.50; 95% CI: 1.04-2.15) was associated with higher adenoma risk. Stratification by ethnicity revealed that these associations ...
RESULTS. VEGF121 and VEGF165 were expressed in 65 % and 75% respectively of the adenomas and the level of this expression varied greatly. There was no correlation between expression of the two receptors or between VEGF expression and adenoma type. Only two adenomas didnt express any VEGF. VEGF-R1 and VEGF-R2 were expressed in 35 % and 25 % respectively of the adenomas and the level of this expression again varied greatly. There was no correlation between receptor expression and VEGF expression, or receptor expression and adenoma type. 55 % of the adenomas didnt express any receptor. Only one adenoma was found not to express any VEGF or receptor ...
The team performed a case-control study in 18 endoscopic units of French nonuniversity hospitals.. A colonoscopy was offered to first-degree relatives of 306 index cases with adenomas of 10 mm if they were alive, aged 40 to 75 years.. Among them, 168 were examined and matched for age, sex, and geographical area with 307 controls.. Controls were randomly selected from 1362 consecutive patients aged 40 to 75 years having undergone a colonoscopy for minor symptoms.. The researchers found the prevalence of large adenomas and cancers was 8% and 4%, in relatives and controls, respectively.. Odds ratios associated with a history of large adenomas in relatives were 2.3 with cancers or large adenomas, 1.2 for small adenomas, and 1.6 for all colorectal neoplasia.. The team found the risk of large adenomas and cancers was higher in relatives of index cases younger than 60 years.. In addition, the research team noted that the risk of large adenomas and cancers was higher when the index case had large distal ...
Colorectal cancer screening is recommended for average-risk persons beginning at age 50. A family history of colorectal cancer is recognized as a risk factor for colorectal adenoma. However, the strength of this association is uncertain. Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer have proved controversial. The conflicting recommendations are partly attributable to the lack of data about the prevalence of CRC and adenomas among 30- to 49-year-old individuals with a first relative history of colorectal cancer. This prospective study will quantify the prevalence of adenomas (any size) and advanced adenomas among 30- to 49-year-old individuals undergoing their first screening colonoscopy because of a first relative history of colorectal cancer and compare the data with controls(asymptomatic subjects without a first relative history of colorectal cancer ...
TY - JOUR. T1 - Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. AU - Adegboyega, Patrick A.. AU - Ololade, Omiyosoye. AU - Saada, Jamal. AU - Mifflin, Randy. AU - Di Mari, John F.. AU - Powell, Don W.. PY - 2004/9/1. Y1 - 2004/9/1. N2 - Purpose: Recent data support the hypothesis that the inducible isoform of cyclooxygenase (COX-2) plays a role in the early stages of colonic carcinogenesis and that nonsteroidal anti-inflammatory drugs (NSAIDs) retard the development of colon cancer by modulating COX-2. However, the cell types responsible for producing COX-2 in colorectal adenomas remain a subject of controversy. Experimental Design: COX-2 expression in normal colonic mucosa (n = 50), hyperplastic polyps (n = 43), sporadic adenomas (n = 67), and invasive colonic adenocarcinoma (n = 39) was studied in formalin-fixed and paraffin-embedded tissue sections from endoscopy biopsy and colonic resection specimens. Immunohistochemistry (avidin-biotin complex technique ...
They recorded the characteristics of any adenomas using standardized protocol. Characteristics were recorded at baseline and at 3 years.. The main outcomes measured by the team were the 3-year overall recurrence, recurrence of multiple and advanced adenomas, and proximal and distal recurrence.. The researchers observed a 3-year recurrence 22% of patients. More than 50% had recurrent adenomas on the proximal colon. After adjustment, the team found that the number of adenomas and their proximal location at baseline were the main predictors of recurrence. When compared with patients who had 1 or 2 adenomas on the distal colon, patients with ≥3 adenomas with at least one of these on the proximal colon had a greater risk of overall recurrence (5.3). These patients also had a greater risk of proximal recurrence (8.5), and advanced adenoma recurrence (5.5).. Dr Bonithon-Kopps team concluded, Follow-up colonoscopies in patients with adenomas should include careful examination of the proximal colon. ...
Pituitary adenomas are tumors that occur in the pituitary gland divided in three categories: benign adenoma, invasive adenoma, or carcinomas. Pituitary adenomas are tumors that occur in the pituitary gland. They are generally divided into three categories dependent upon their biological functioning: benign adenoma, invasive adenoma, or carcinomas, with carcinomas accounting for 0.1% to 0.2%, approximately. Read More…. Read More.... ...
NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. We examined the relationship between NQO1C609T, mEH3, mEH4 and risk of sporadic distal colorectal adenomas in one of the largest case-control studies of 946 polyp-free controls and 894 cases, all participants of the UK Flexible Sigmoidoscopy Screening (UKFSS) Trial. The polymorphisms were examined as independent risk factors and evidence for interaction with smoking and alcoholic drinks was sought. The NQO1 609*T allele was positively associated with high-risk adenoma in this population [odds ratio (OR), 1.36; 95% confidence interval (CI), 1.02-1.83]. Elevated risk estimates were seen in smokers independently of the genotype but the association was stronger among current smokers with ...
Če se ne sprejmejo terapevtski ukrepi, se pri bolnikih z adenomi prostate lahko razvije kronična ledvična odpoved. Pri adenoma prostate se včasih razvije akutno zadrževanje urinov. Pacient ne more urinirati, ko je mehur je poln, kljub intenzivni želji. Za odpravo zadrževanja sečnice se pri moških kateterizira mehur, včasih pa je nujna operacija ali prebadanje mehurja.. Še en zaplet pri adenoma prostate je hematurija. Pri številnih bolnikih je opaziti mikroekemurozo, vendar se pojavijo tudi pogoste intenzivne krvavitve iz tkiva adenoma (v primeru poškodb zaradi manipulacije) ali krčne žile na območju vratu mehurja. S tvorjenjem strdkov je mogoče razviti tamponado mehurja, v katerem je nujna kirurgija potrebna. Pogosto vzrok krvavitve v adenoma prostate postane diagnostična ali terapevtska kateterizacija.. Kamni mehurja pri adenoma prostate lahko nastanejo zaradi stoječega urin ali migrirajo iz ledvic in sečil. Pri cistolitiaziji se klinična slika adenoma prostate dopolnjuje s ...
Zdravljenje adenoma prostate z repom. Kljub očitnemu napredku pri zdravljenju adenoma prostate, tradicionalne medicine, so metode, uporabljene za zdravljenje te bolezni pred stoletjem, še vedno pomembne. Takšno zdravljenje adenoma prostate z ljudskimi zdravili je zelo učinkovito, zato bo rezultat opazen hitro. Sončnična semena. Priporočljivo je, da jedo suho (vendar ne ocvrto) bučno seme. Pred uporabo je treba izdelek očistiti iz trde lupine, zelena folija pa mora ostati. Vzemite to sredstvo priporočljivo za gramov na dan za mesec. ljudsko zdravljenje. Ali se adenoma zdravi brez prizadevanj pacienta in kakšne so možne posledice, na recepciji zdravnik vsakemu posamezniku pojasni posamezno. Sprememba načina. Bolniki z adenoma prostate so večinoma starejši od 50 let. Pogosteje so moški s prekomerno težo, ki se ne želijo omejiti v hrani, preživeti čas na televiziji. Pri ljudskih metodah je bilo zdravljenje s čebelasto poddomenom adenoma prostate pridobljeno z obsežnim obsegom. ...
Medical information, Adenoma - secreting. Definition of Adenoma - secreting, symptoms of Adenoma - secreting, treatment of Adenoma - secreting, and prevention of Adenoma - secreting. Exams and Tests Adenoma - secreting.
Among women at high risk for cardiovascular disease, daily supplementation with a combination of folic acid, vitamin B6, and vitamin B12 did not affect the risk of colorectal adenoma, a post hoc analy
Incidence of colorectal lesions with respect to high grade dysplasia, adenomas with villous features, adenomas 1 cm or greater, multiple adenomas, polyps ,/= 0.3 cm, total advanced colorectal events (defined as the number of patients with at least one high risk adenoma, 2nd primary colorectal cancer, colorectal cancer recurrence, or metastasis) or total colorectal cancer events (defined as the number of patients with at least one advanced colorectal event or polyp)at 3 years and 8 years ...
TY - JOUR. T1 - Novel patterns of gene expression in pituitary adenomas identified by complementary deoxyribonucleic acid microarrays and quantitative reverse transcription-polymerase chain reaction. AU - Evans, Chheng Orn. AU - Young, Andrew N.. AU - Brown, Milton R.. AU - Brat, Daniel J.. AU - Parks, John S.. AU - Neish, Andrew S.. AU - Oyesiku, Nelson M.. PY - 2001. Y1 - 2001. N2 - Pituitary adenomas account for approximately 10% of intracranial tumors, but little is known of the oncogenesis of these tumors. The identification of tumor-specific genes may further elucidate the pathways of tumor formation. We used complementary DNA microarrays to examine gene expression profiles in nonfunctioning, PRL, GH, and ACTH secreting adenomas, compared with normal pituitary. Microarray analysis showed that 128 of 7075 genes examined were differentially expressed. We then analyzed three genes with unique expression patterns and oncogenic importance by RT-real time quantitative PCR in 37 pituitaries. ...
The majority of people with adrenal adenomas will have no symptoms and the growths will only be discovered during a MRI or CT completed for other reasons. These non-functioning adrenal adenomas do not require follow up treatment.. Functional adrenal adenomas will increase hormones made in the adrenal gland.. ...
Background: The transition from normal epithelium to adenoma and, to invasive carcinoma in the human colon is associated with acquired molecular events taking 5-10 years for malignant transformation. We discovered CCAT1, a non-coding RNA over-expressed in colon cancer (CC), but not in normal tissues, thereby making it a potential disease-specific biomarker. We aimed to define and validate CCAT1 as a CC-specific biomarker, and to study CCAT1 expression across the adenoma-carcinoma sequence of CC tumorigenesis.Methods: Tissue samples were obtained from patients undergoing resection for colonic adenoma(s) or carcinoma. Normal colonic tissue (n = 10), adenomatous polyps (n = 18), primary tumor tissue (n = 22), normal mucosa adjacent to primary tumor (n = 16), and lymph node(s) (n = 20), liver (n = 8), and peritoneal metastases (n = 19) were studied. RNA was extracted from all tissue samples, and CCAT1 expression was analyzed using quantitative real time-PCR (qRT-PCR) with confirmatory in-situ ...
Da bi zmanjšali te zaplete po odstranitvi adenoma zdravniki prostate spremenjeno sestavo raztopine, izboljšanje medicinske opreme, prilagojene tehniko operacije. Po statističnih podatkih se takšne posledice pojavljajo z rednostjo približno 0,1 - 6,5%. težave uriniranje. Po odstranitvi adenoma prostate se nekaj časa ohranja erektilna funkcija. Težavo odpravite na več načinov: Uporaba inhibitorjev fosfodiesteraze-5 (iFDE-5) 30 dni po operaciji. Ti vključujejo: sildenafil, tadalafil, vardenafil. Ta metoda se izvaja, da se prepreči rast vezivnega tkiva in pojav brazgotin.Če ste pred operacijo imeli težave z močjo, potem je lahko po resnih težavah z erekcijo. Da bi se moško spolno življenje vrnilo v normalno stanje po odstranitvi prostate, Odstranitev adenoma prostate - kakšne so posledice operacije? Vadba po odstranitvi raka prostate bolečina v povečanje spolne moči in Prostatitis in njen vpliv na partnerja zdravljenje adenoma problemi z erekcijo forum. Kirurgija za adenoma ...
Pri moškem v 72 letih je prišlo do adenoma prostate. Obrnil se je k zdravniku, ko je bila bolezen že v zanemarjeni obliki, brez katetra pa ni bilo mogoče izprazniti mehurja. Takoj je ponudil operacijo za odstranitev adenoma, se je strinjal, odšel v bolnišnico, a ko sem videl post-kirurške bolnike, prestrašeni, izkazalo, da je z operacijo in je bil zaključen domov s katetrom. Po nasvetu urologu začel zdravljenje adenoma folk pravna sredstva: prvi dan posta mora jesti 0,5 skodelice orehov, v drugem - pol skodelice sončničnih semen, tretji dan od povprečja žarnice. Nadaljevati to zdravljenje prostate za tri mesece.. Moški je to zdravilo uporabljal in adenoma je izginila, a ker je imel nezdrav način življenja, se je nekaj let kasneje ponovno pojavil. Potem se je odločil, da bi adenoma zdravil z magnetom. Kupil je biokorrektorja iz podjetja Nevoton, vendar je bil učinek zdravljenja majhen. Potem je po mnenju zdravnika moški večkrat vzel magnet - od zvočnika radia. Poleg adenomom ...
TY - JOUR. T1 - Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas. AU - Carvajal-Carmona, Luis. AU - Zauber, Ann G.. AU - Jones, Angela M.. AU - Howarth, Kimberley. AU - Wang, Jiping. AU - Cheng, Timothy. AU - Riddell, Robert. AU - Lanas, Angel. AU - Morton, Dion. AU - Bertagnolli, Monica M.. AU - Tomlinson, Ian. PY - 2013/1. Y1 - 2013/1. N2 - Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842, rs4444235, rs1957636, rs4939827, and rs961253) were over-represented in CRC-free patients with adenomas, compared with controls. Ten other CRC-associated SNPs (rs6691170, rs6687758, rs16892766, rs7136702, rs11169552, rs4779584, rs9929218, rs10411210, rs4813802, and rs4925386) were not ...
• Benign adenomas in the colon increased slightly in participants using statins. • Preliminary data suggesting statins may prevent colorectal cancer were not supported by this secondary analysis. WASHINGTON, D.C. - Statins did not protect patients against colorectal adenomas, which are benign precursors of colorectal cancer, according to results of a secondary analysis of the…
This study investigated quantitated expression of dopamine 2 receptor (D2R) and somatostatin receptors of the five types (SSTR1-SSTR5) in a large series of clinically non-functioning pituitary adenomas (CNFAs). Co-expression of these receptors in individual adenomas was studied as well as correlation between receptor types. Adenoma tissue from 198 patients who underwent surgery for CNFAs was analyzed by immunohistochemistry and quantitative real-time PCR. D2R and SSTR1-3 mRNA was expressed in all 198 adenomas. SSTR4 and SSTR5 were detectable in 85 % and 61 % of adenomas, respectively. Expression of D2R was significantly higher than that of the somatostatin receptors. The median relative expressions were as follows from highest D2R || SSTR3 | SSTR2 | SSTR1 | SSTR5 | SSTR4. High relative expression (ratio to beta-glucuronidase mRNA | 1) of D2R was found in 60 % of tumors, high expression of SSTR1 in 7.5 %, SSTR2 in 7 %, SSTR3 in 4 % and SSTR5 in 0.5 %. The quantity of D2R correlated positively with
Objectives: It is known that patients with pituitary adenomas, especially acromegaly, frequently suffer from pain syndromes such as headache and arthralgia. Whether pain exists and to what extent in Cushing s disease (CD), reflecting chronic cortisol excess, is not clear. We hypothesized that pain patterns should be also altered and investigated pain laterisation, clinical characteristics, phenotypes as well as underlying predictors.. Methods: In a cross-sectional study, we assessed 50 patients with CD and compared them to 60 patients with non-functioning pituitary adenomas (NFPA). Specific pain patterns were measured using three standardized pain questionnaires, MIDAS (Migraine Disability Assessment), the painDETECT and the DGSS (German Society for the Study of Pain) questionnaire.. Results: According to the DGSS questionnaire, patients with CD complained significantly more often of any sort of pain (76.0 versus 51.7%; P=0.010) compared to patients with NFPA. In the MIDAS headache ...
TY - JOUR. T1 - RNF43 Is an Early and Specific Mutated Gene in the Serrated Pathway, With Increased Frequency in Traditional Serrated Adenoma and Its Associated Malignancy. AU - Tsai, Jia Huei. AU - Liau, Jau Yu. AU - Yuan, Chang Tsu. AU - Lin, Yu Lin. AU - Tseng, Li Hui. AU - Cheng, Mei Ling. AU - Jeng, Yung Ming. PY - 2016/6/14. Y1 - 2016/6/14. N2 - RNF43 is an E3 ligase that suppresses the Wnt/β-catenin signaling pathway and is frequently mutated in microsatellite-unstable colorectal carcinoma. To investigate the pathogenetic role of RNF43 in the serrated pathway, we conducted mutation analysis of RNF43 in several types of colorectal neoplasms. RNF43 mutation was found in 2 of 20 (10%) sessile serrated adenomas, 10 of 36 (28%) traditional serrated adenomas, 7 of 37 (19%) traditional serrated adenomas with cytologic dysplasia, and 9 of 31 (29%) BRAF-mutated/microsatellite-stable colorectal carcinomas; however, no mutation was found in 30 tubulovillous/villous adenomas. All mutations were ...
TY - JOUR. T1 - COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics. AU - McLean, M. H.. AU - Murray, G. I.. AU - Fyfe, N.. AU - Hold, G. L.. AU - Mowat, N. A. G.. AU - El-Omar, E. M.. PY - 2008/6. Y1 - 2008/6. N2 - Aims: To assess cyclooxygenase-2 (COX-2) expression in sporadic colonic adenomas and to explore the association of COX-2 positivity with adenoma characteristics linked to increased risk of malignant transformation.Methods and results: COX-2 expression and localization were assessed in 64 colorectal adenomas and 35 paired adjacent normal colonic mucosal biopsy specimens. The number of adenoma specimens was then extended to include polyps exhibiting an increasing degree of epithelial dysplasia. Forty colonic hyperplastic polyps were also identified from the pathology diagnostic database and included in the analysis. Immunohistochemistry was performed with the Envision+(TM) peroxidase-linked biotin-free system incorporating a signal ...
TY - JOUR. T1 - Axis-specific analysis and predictors of endocrine recovery and deficits for non-functioning pituitary adenomas undergoing endoscopic transsphenoidal surgery. AU - Hwang, Jenie Y.. AU - Aum, Diane J.. AU - Chicoine, Michael R.. AU - Dacey, Ralph G.. AU - Osbun, Joshua W.. AU - Rich, Keith M.. AU - Zipfel, Gregory J.. AU - Klatt-Cromwell, Cristine N.. AU - McJunkin, Jonathan L.. AU - Pipkorn, Patrik. AU - Schneider, John S.. AU - Silverstein, Julie M.. AU - Kim, Albert H.. N1 - Funding Information: AHK is a consultant for Monteris Medical and has received research grants from Monteris Medical and Stryker, regarding a clinical outcomes study for a dural substitute, which has no direct relation to this study. JMS is a primary investigator for clinical studies with Chiasma, Corcept, and StrongBridge, none of which has direct relation to this study. CKC is a consultant for Medtronitcs, which has no direct relation to this study. JSS is a consultant for Medtronics, Olympus, Optinose, ...
OBJECTIVE: BRAF is an oncogene that is commonly mutated in both melanomas and papillary thyroid carcinomas, usually at position V600E that leads to constitutive activity in the Ras-mitogen-activated protein kinase (MAPK) pathway. We speculated that this same gene may be either mutated at this site, or overexpressed, in pituitary adenomas. DESIGN AND MEASUREMENTS: We sequenced 37 pituitary adenomas for a mutation at the V600E position. In addition, we investigated B-Raf mRNA expression in normal pituitary (n = 5) and nonfunctioning pituitary adenomas (NFPA) (n = 6) by semiquantitative PCR, and in a further 27 pituitary adenomas of various types and 10 normal pituitaries using real-time quantitative PCR. Finally, we explored B-Raf protein expression in 10 normal pituitaries and 12 NFPAs. RESULTS: No sequence mutations for the substitution V600E were identified. B-Raf mRNA was overexpressed in pituitary adenomas compared to normal pituitary, and this was entirely due to overexpression in NFPAs. ...
TY - JOUR. T1 - Immunohistochemical Studies of Chromogranins (A and C) in Pituitary Adenomas. AU - Oda, K.. AU - Inada, K.. AU - Osamura, R. Y.. PY - 1991. Y1 - 1991. N2 - Expression of Chromogranin A and C was examined immunohistochemically on 4S surgically obtained pituitary adenomas. Positive rate of chromogranin A was 40.0% and chromogranin C was positive in 8.0% of 4S pituitary adenomas. Chromogranin A was expressed frequently in adenomas in which at least one of the FSH alpha, FSH beta, LH beta and TSH beta subunits was positive. It also expressed frequently in non-functioning adenomas. The positive rate of chromogranin A was low in GH or PRL positive adenomas. These findings suggest that chromogranin could be a parameter of the functional differentiation of the pituitary adenomas.. AB - Expression of Chromogranin A and C was examined immunohistochemically on 4S surgically obtained pituitary adenomas. Positive rate of chromogranin A was 40.0% and chromogranin C was positive in 8.0% of 4S ...
TY - JOUR. T1 - Methionine Synthase D919G Polymorphism, Folate Metabolism, and Colorectal Adenoma Risk. AU - Goode, Ellen L.. AU - Potter, John D.. AU - Bigler, Jeannette. AU - Ulrich, Cornelia M.. PY - 2004/1/1. Y1 - 2004/1/1. N2 - Methionine synthase [5-methyltetrahydrofolate-homocysteine S-methyltransferase (MTR)] is involved in folate-mediated one-carbon metabolism, a pathway known to play a role in colorectal carcinogenesis. We investigated whether the MTR D919G polymorphism was associated with risk of colorectal adenoma in a colonoseopy-based study of 513 cases and 609 controls from Minneapolis, MN. Adenoma risk appeared nonsignificantly increased among women with DG or GG genotype [adjusted odds ratio (OR) versus DD, 1.4; 95% confidence interval (CI), 0.9-2.1] but not men (OR, 1.0; 95% CI, 0.7-1.5). An interaction with methionine intake was observed among women, such that low versus high intake was associated with a 2.3-fold increased risk only among those with DG or GG genotype (95% CI, ...
Human pituitary tumors are generally benign adenomas causing considerable morbidity due to excess hormone secretion, hypopituitarism, and other tumor mass effects. Pituitary tumors are highly heterogeneous and difficult to type, often containing mixed cell phenotypes. We have used calcium imaging followed by multiple immunocytochemistry to type growth hormone secreting (GHomas) and non-functioning pituitary adenomas (NFPAs). Individual cells were typed for stored hormones and calcium responses to classic hypothalamic releasing hormones (HRHs). We found that GHomas contained growth hormone cells either lacking responses to HRHs or responding to all four HRHs. However, most GHoma cells were polyhormonal cells responsive to both thyrotropin-releasing hormone (TRH) and GH-releasing hormone. NFPAs were also highly heterogeneous. Some of them contained ACTH cells lacking responses to HRHs or polyhormonal gonadotropes responsive to LHRH and TRH. However, most NFPAs were made of cells storing no hormone and
MATERIALS AND METHODS: Conventional MR imaging with contrast-enhanced T1WI and arterial spin-labeled perfusion imaging were performed before surgery in 11 consecutive patients with nonfunctioning pituitary macroadenomas. ROIs were drawn on the tumors, and the degrees of enhancement were calculated by dividing the signal intensity on the contrast-enhanced T1WI by that on the nonenhanced TIWI. As an index of tumor perfusion, a quantitative analysis was performed by using normalized tumor blood flow values calculated by dividing the mean value of the tumor region of interest by the mean region of interest values in the 2 cerebellar hemispheres. The relative microvessel attenuation was determined as the total microvessel wall area divided by the entire tissue area on CD-31-stained specimens. The degree of enhancement and the normalized tumor blood flow values were compared with relative microvessel attenuation. Additionally, intra- and postoperative tumor hemorrhages were visually graded.. ...
CONTEXT: Genetic abnormalities, such as those of multiple endocrine neoplasia type 1 (MEN1) and Cyclin D1 (CCND1) genes, occur in |50% of nonhereditary (sporadic) parathyroid adenomas. OBJECTIVE: To identify genetic abnormalities in nonhereditary parathyroid adenomas by whole-exome sequence analysis. DESIGN: Whole-exome sequence analysis was performed on parathyroid adenomas and leukocyte DNA samples from 16 postmenopausal women without a family history of parathyroid tumors or MEN1 and in whom primary hyperparathyroidism due to single-gland disease was cured by surgery. Somatic variants confirmed in this discovery set were assessed in 24 other parathyroid adenomas. RESULTS: Over 90% of targeted exons were captured and represented by more than 10 base reads. Analysis identified 212 somatic variants (median eight per tumor; range, 2-110), with the majority being heterozygous nonsynonymous single-nucleotide variants that predicted missense amino acid substitutions. Somatic MEN1 mutations occurred in six
Somatotroph adenomas secrete supraphysiological amounts of GH, causing acromegaly. We have previously hypothesized that epithelial mesenchymal transition (EMT) may play a central role in the progression of these adenomas and that epithelial splicing regulator 1 (ESRP1) may function prominently as a master regulator of the EMT process in pituitary adenomas causing acromegaly. To further elucidate the role of ESRP1 in somatotroph adenomas and in EMT progression, we used RNA sequencing (RNAseq) to sequence somatotroph adenomas characterized by high and low ESRP1 levels. Transcripts identified by RNAseq were analyzed in 65 somatotroph adenomas and in GH-producing pituitary rat cells with a specific knockdown of Esrp1. The clinical importance of the transcripts was further investigated by correlating mRNA expression levels with clinical indices of disease activity and treatment response. Many of the transcripts and isoforms identified by RNAseq and verified by quantitative PCR were involved in ...
Most patients with pituitary adenomas present with signs and symptoms of hormone hypersecretion (eg, hyperprolactinemia, growth hormone [GH] excess, or hypercortisolism). However, 25 to 30 percent of pituitary adenomas are clinically nonfunctioning o
Looking for online definition of acidophile pituitary adenoma in the Medical Dictionary? acidophile pituitary adenoma explanation free. What is acidophile pituitary adenoma? Meaning of acidophile pituitary adenoma medical term. What does acidophile pituitary adenoma mean?
The histopathology of 12 patients with adenoma of the ampulla of Vater was examined to trace the adenoma-carcinoma sequence of the ampulla of Vater. Immunohistochemistry for carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 was also performed. Four large adenomas with mild dysplasia also had foci of moderate dysplasia while another one contained foci of severe dysplasia (intramucosal carcinoma). Immunohistochemically, adenomas of mild to moderate dysplasia had either linear CEA and CA19-9 immunoreactants at the apical portions, or fine granular immunoreactants in the cytoplasm of adenoma cells. In addition, adenomas of severe dysplasia (intramucosal carcinoma) showed a more diffuse or dense immunoreactivity for these two substances in the cytoplasm. These results are consistent with the adenoma-carcinoma sequence for the ampulla of Vater. The immunohistochemistry for CEA and CA19-9 was representative of the degree of dysplasia in the adenoma cells, but the relationship was not ...
TY - JOUR. T1 - Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum. AU - Matsubara, Akiko. AU - Sekine, Shigeki. AU - Kushima, Ryoji. AU - Ogawa, Reiko. AU - Taniguchi, Hirokazu. AU - Tsuda, Hitoshi. AU - Kanai, Yae. PY - 2013/3. Y1 - 2013/3. N2 - Gastric and duodenal adenomas exhibit a significant morphological and phenotypical diversity and are classified into intestinal-type, foveolar-type and pyloric gland adenomas. We analysed the mutations in GNAS, KRAS, BRAF and CTNNB1 and the expressions of mismatch repair (MMR) proteins in 80 gastric and 32 duodenal adenomas with histologically distinct subtypes, as well as in 71 gastric adenocarcinomas. Activating GNAS mutations were found in 22 of the 35 pyloric gland adenomas (PGAs; 63%) but in none of the foveolar-type or intestinal-type adenomas or the adenocarcinomas. Fourteen PGAs (41%), two foveolar-type adenomas (9%), five intestinal-type adenomas (9%) and one adenocarcinoma (1%) had KRAS mutations. BRAF ...
Light bodies are large cytoplasmic granules originally described in the gonadotrophic cells of the rat pituitary gland. In order to determine whether similar bodies occur in the human anterior pituitary gland, 89 pituitary adenomas and periadenomatous tissue from 20 cases were examined by transmission electron microscopy. Double membrane bound bodies with filamentous internal structure identical to rodent light bodies were identified in 10 hormone-producing adenomas: 5 PRL, 1 PRL-GH, 2 GH, and 2 ACTH-producing tumours. No light bodies were found in the remaining 79 tumours nor in the pituitary cells in periadenomatous tissue from 20 cases. These results show that some human pituitary adenomas may contain light bodies identical to those seen in gonadotrophs of rat pituitary ...
Background and aims: Colonoscopy is an established method of colorectal cancer screening, but has an adenoma miss rate of 10-20%. Detection rates are expected to improve with optimised visualisation methods. This prospective randomised study evaluated narrow-band imaging (NBI), a new technique that may enhance image contrast in colon adenoma detection.. Methods: Eligible patients presenting for diagnostic colonoscopy were randomly assigned to undergo wide-angle colonoscopy using either conventional high-resolution imaging or NBI during instrument withdrawal. The primary outcome parameter was the difference in the adenoma detection rate between the two techniques.. Results: A total of 401 patients were included (mean age 59.4 years, 52.6% men). Adenomas were detected more frequently in the NBI group (23%) than in the control group (17%) with a number of 17 colonoscopies needed to find one additional adenoma patient; however, the difference was not statistically significant (p = 0.129). When the ...
CONTEXT: Pituitary adenomas and pheochromocytomas/paragangliomas (pheo/PGL) can occur in the same patient or in the same family. Coexistence of the two diseases could be due to either a common pathogenic mechanism or a coincidence. OBJECTIVE: The objective of the investigation was to study the possible coexistence of pituitary adenoma and pheo/PGL. DESIGN: Thirty-nine cases of sporadic or familial pheo/PGL and pituitary adenomas were investigated. Known pheo/PGL genes (SDHA-D, SDHAF2, RET, VHL, TMEM127, MAX, FH) and pituitary adenoma genes (MEN1, AIP, CDKN1B) were sequenced using next generation or Sanger sequencing. Loss of heterozygosity study and pathological studies were performed on the available tumor samples. SETTING: The study was conducted at university hospitals. PATIENTS: Thirty-nine patients with sporadic of familial pituitary adenoma and pheo/PGL participated in the study. OUTCOME: Outcomes included genetic screening and clinical characteristics. RESULTS: Eleven germline mutations (five
Pituitary adenomas account for up to 15% of intracranial masses with the most common subtypes being prolactinomas and non-functioning pituitary adenomas (NFPA).
TY - JOUR. T1 - C-reactive protein and colorectal adenomas. T2 - Self Defense Forces Health Study. AU - Otake, Toshie. AU - Uezono, Kousaku. AU - Takahashi, Ryota. AU - Fukumoto, Jin. AU - Tabata, Shinji. AU - Abe, Hiroshi. AU - Tajima, Osamu. AU - Mizoue, Tetsuya. AU - Ohnaka, Keizo. AU - Kono, Suminori. N1 - Copyright: Copyright 2009 Elsevier B.V., All rights reserved.. PY - 2009. Y1 - 2009. N2 - Chronic inflammation has been implicated in colorectal carcinogenesis. Several studies have investigated the relationship between C-reactive protein (CRP), a biomarker of inflammation, and colorectal cancer and adenomas, resulting in inconsistent findings. The present study examined the relationship between circulating levels of high-sensitivity CRP and colorectal adenomas. The study subjects comprised 646 cases of colorectal adenoma and 635 controls of normal total colonoscopy among men receiving a preretirement health examination at two hospitals of the Self Defense Forces. Statistical adjustment ...
in Endocrine-Related Cancer (2011). Mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene are associated with pituitary adenomas that usually occur as familial isolated pituitary adenomas (FIPA). Detailed pathological ... [more ▼]. Mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene are associated with pituitary adenomas that usually occur as familial isolated pituitary adenomas (FIPA). Detailed pathological and tumor genetic data on AIP mutation-related pituitary adenomas are scarce. Non-identical twin females presented as adolescents to the emergency department with severe progressive headaches caused by large pituitary macroadenomas requiring emergency neurosurgery; one patient had incipient pituitary apoplexy. Post-surgically the patients were found to have silent somatotrope adenomas on pathological examination. Furthermore, the light microscopic, immunohistochemical and electron microscopic studies demonstrated tumors of virtually identical ...
A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete: growth hormone (GH)-secreting, prolactin (PRL)-secreting, adrenocorticotropin (ACTH)-secreting, thyroid-stimulating hormone (TSH)-secreting, and plurihormonal (GH and TSH) tumors. Familial and sporadic forms have been reported. The transmission pattern of familial PITA5 is consistent with autosomal dominant inheritance with reduced penetrance ...
A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete: growth hormone (GH)-secreting, prolactin (PRL)-secreting, adrenocorticotropin (ACTH)-secreting, thyroid-stimulating hormone (TSH)-secreting, and plurihormonal (GH and TSH) tumors. Familial and sporadic forms have been reported ...
in Endocrine Reviews (2013). Pituitary adenomas are one of the most frequent intracranial tumors and occur with a prevalence of approximately 1:1000 in the developed world. Pituitary adenomas have a serious disease burden, and their ... [more ▼]. Pituitary adenomas are one of the most frequent intracranial tumors and occur with a prevalence of approximately 1:1000 in the developed world. Pituitary adenomas have a serious disease burden, and their management involves neurosurgery, biological therapies, and radiotherapy. Early diagnosis of pituitary tumors while they are smaller may help increase cure rates. Few genetic predictors of pituitary adenoma development exist. Recent years have seen two separate, complimentary advances in inherited pituitary tumor research. The clinical condition of familial isolated pituitary adenomas (FIPA) has been described, which encompasses the familial occurrence of isolated pituitary adenomas outside of the setting of syndromic conditions like multiple ...
Growth hormone-producing adenoma definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
CONTEXT: Appropriate cell-to-cell adhesion is fundamental for the epithelial phenotype of pituitary cells. Loss of the adhesion protein E-cadherin has been associated with invasiveness, metastasis, and poor prognosis in cancers of epithelial origin. In somatotroph adenomas, a variable and reduced expression of E-cadherin has been demonstrated. In addition, nuclear translocation of E-cadherin was found to correlate with pituitary tumor invasion.. OBJECTIVE: The objective was to examine the protein expression of E-cadherin in somatotroph pituitary adenomas in relation to adenoma size, invasiveness, and somatostatin analog (SMS) efficacy.. PATIENTS AND METHODS: Eighty-three patients were included, and 29 were treated preoperatively with SMS. Adenoma E-cadherin protein expression was analyzed by Western blot (61 patients) and immunohistochemistry (IHC) (80 patients) with antibodies directed against both extracellular and intracellular domains (IHC). The acute (direct surgery group) and long-term ...
1.Pituitary adenomas are benign and slow-growing tumours whose clinical manifestations depend mainly on the secretory activity of the adenomatous cells. Except for prolactinomas, surgical removal of the tumour is the therapy of choice.. 2.Despite extensive research on their clinical and pathophysiological aspects, few studies have explored the oncological characteristics of these rare lesions. Among these, the growth fraction of pituitary adenomas has been determined by different methods, of which the most useful are those performed in archival material.. 3.The results reported in the literature show that adrenocorticotropic hormone-secreting tumours seem to be characterized by a higher proliferation index than the other types of pituitary adenomas, despite their usually small tumour size.. 4.In small series of patients radiotherapy and medical treatment with dopaminergic drugs and octreotide were associated with a lower proliferation index than untreated tumours. Tumour size was not correlated ...
BACKGROUND: Colonoscopy is the gold standard investigation for the diagnosis of bowel pathology and colorectal cancer screening. Adenoma detection rate is a marker of high quality colonoscopy and a high adenoma detection rate is associated with a lower incidence of interval cancers. Several technological advancements have been explored to improve adenoma detection rate. A new device called Endocuff Vision™ has been shown to improve adenoma detection rate in pilot studies. METHODS/DESIGN: This is a prospective, multicenter, randomized controlled trial comparing the adenoma detection rate in patients undergoing Endocuff Vision™-assisted colonoscopy with standard colonoscopy ...
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The pathogenesis and risk of malignancy of traditional serrated adenomas (TSAs) are unclear. In North America, TSAs are relatively uncommon, occur mainly in the left colon, and in some studies, have not been shown to have a strong association with hyperplastic polyp (HPP) or sessile polyp adenoma (S …
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Elevated total dietary fiber intake was associated with a reduced risk of incident distal colorectal adenoma (OR highest v. lowest tertile of intake 0.76, 95%CI: 0.63-0.91, Ptrend=0.003), but not recurrent adenoma (Ptrend =0.67). Although the association was not statistically significant for colorectal cancer overall (HR 0.85, 95%CI: 0.70-1.03, Ptrend=0.10), a reduced risk of distal colon cancer was observed with increased total fiber intake (HR 0.62, 95%CI: 0.41-0.94, Ptrend=0.03). Protective associations were most notable for fiber originating from cereals or fruit.. ...
Pituitary adenoma (PA) is usually a common benign neuroendocrine tumor; however, the incidence and proportion of hormone-producing PAs in Korean patients remain unknown. slightly more prevalent in women (M: F = 1:1.17) with a mean age of 48.8 yr (9-80 yr). Immunohistochemical analysis revealed that prolactin-producing PAs (16.6%) and growth hormone-producing adenomas (9.2%) were the most common functional PAs. Plurihormonal PAs and nonfunctioning (null cell) adenomas were found in 14.9% and 42.4% of patients with PAs, respectively. The recurrence rate of PAs was 11.1%, but nearly 0% for the remaining benign lesions such as RCCs. 25.4% of patients with PAs were treated by gamma-knife after surgery due to residual tumors or regrowth of residual tumor. In conclusion, the pituitary lesions and the proportions of hormone-producing PAs in Korean patients are similar to those of previous reports except nonfunctioning Etizolam (null cell) PAs, which are unusually frequent. Graphical Abstract Keywords: ...
Looking for online definition of mixed-cell adenoma in the Medical Dictionary? mixed-cell adenoma explanation free. What is mixed-cell adenoma? Meaning of mixed-cell adenoma medical term. What does mixed-cell adenoma mean?
Mar 26, 2015 Yoga-based exercise has proven to be beneficial for practitioners, including cancer A study in prostate cancer survivors found that circulating levels of CRP 1991), osteoporosis (Devogelaer and de Deuxchaisnes 1993), and Physical activity, obesity, and risk for colon cancer and adenoma.Prostate Adenoma Causes. Prostate the importance of an increased intake of vitamin E as a protective factor with clubbell Yoga;.Caratteristiche cura delladenoma della prostata: domande e risposte. unanalisi fatta da un ignorante, e lì non cè bisogno di un yoga e altre.An adenoma is a benign tumor of epithelial tissue with glandular origin, glandular characteristics, or both. Adenomas can grow from many glandular organs , including the adrenal glands , pituitary gland , thyroid , prostate , and others.Incurabile prostatite cronica elenco di farmaci da un adenoma e prostatite, come trattare linfiammazione della prostata umore Sytina.Adenomectomia prostatica (animazione La mano delloperatore è in ...
Canalicular adenoma • Canine tooth • Cantilever mechanics • Carbon dioxide laser • Caries vaccine • Carnassial • Case School of ... Pleomorphic adenoma • Pleurodont • Plica fimbriata • Polk E. Akers • Polymorphous low-grade adenocarcinoma • Polynoxylin • ...
... or parathyroid adenoma). It is used by surgeons to locate ectopic parathyroid adenomas, most commonly found in the anterior ... Parathyroid adenomas have been linked with DDT although a causal link has not yet been established. Normal parathyroid glands ... "Parathyroid Adenoma". BrighamRAD Teaching Case Database. Archived from the original on 2011-07-16. Carroll MF, Schade DS (May ... Parathyroid adenomas are very rarely detectable on clinical examination. Surgical removal of a parathyroid tumor eliminates the ...
TCF4 Pituitary adenoma, ACTH-secreting; 219090; AIP Pituitary adenoma, growth hormone-secreting; 102200; AIP Pituitary adenoma ... PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, salivary gland pleomorphic; 181030; PLAG1 Adenomatous polyposis ... EIF2B4 Leydig cell adenoma, somatic, with precocious puberty; 176410; LHCGR Leydig cell hypoplasia with hypergonadotropic ... SCN4A Parathyroid adenoma with cystic changes; 145001; HRPT2 Parathyroid carcinoma; 608266; HRPT2 Parietal foramina 1; 168500; ...
This adenoma is extremely rare; when it occurs, it usually occurs in women. Often the adenoma is harmless but is removed after ... There are three main treatments for Hürthle cell adenomas. Once the adenoma is detected most often the nodules removed to ... 1998), "Unilateral lobectomy for Hürthle cell adenoma", Am Surg, 64 (8): 729-732, PMID 9697901. "Hurthle Cell Adenoma". www. ... "Appearance of Hürthle cell carcinoma soon after surgical extirpation of Hürthle cell adenoma and follicular adenoma of the ...
... villous adenoma): Tubular Adenoma: 5% risk of cancer Tubulovillous adenoma: 20% risk of cancer Villous adenoma: 40% risk of ... Neoplastic polyps of the bowel are often benign hence called adenomas. An adenoma is a tumor of glandular tissue, that has not ... villous adenoma which are long finger like projections on the surface, and tubulovillous adenoma which has features of both.: ... villous adenomas are no more likely than tubular or tubulovillous adenomas to become cancerous if their sizes are all the same ...
... such that oxyphil cell parathyroid adenomas have a very high avidity for sestamibi, while chief cell parathyroid adenomas have ... A sestamibi parathyroid scan is a procedure in nuclear medicine which is performed to localize parathyroid adenoma, which ... Adequate localization of parathyroid adenoma allows the surgeon to use a minimally invasive surgical approach. Tc99m-sestamibi ... Approximately 60 percent of parathyroid adenomas may be imaged by sestamibi scanning. The natural distribution of causation for ...
Types include: Parathyroid adenoma Parathyroid carcinoma[citation needed] Sekine O, Hozumi Y, Takemoto N, Kiyozaki H, Yamada S ... Konishi F (March 2004). "Parathyroid adenoma without hyperparathyroidism". Japanese Journal of Clinical Oncology. 34 (3): 155-8 ...
ISBN 978-0-07-147247-0. Sekine O, Hozumi Y, Takemoto N, Kiyozaki H, Yamada S, Konishi F (March 2004). "Parathyroid adenoma ... Primary hyperparathyroidism Solitary parathyroid adenoma Primary parathyroid hyperplasia Parathyroid carcinoma Multiple ...
Hepatocellular adenomas (also called hepatocellular adenoma) are rare benign liver tumors made up of hepatocytes, with ... Liver cell adenomatosis differs from hepatic adenomas by its definition of more than 10 hepatic adenomas that are in both liver ... The best way to biopsy suspected hepatic adenoma is via open or laparoscopic excisional biopsy. Because hepatocellular adenomas ... the adenoma is recommended to be surgically removed. Like most liver tumors, the anatomy and location of the adenoma determines ...
medscape >Adrenal Adenoma Imaging. Author: Perry J Horwich. Chief Editor: Eugene C Lin. Updated: Apr 21, 2011 Feeman, Timothy G ... tumor with a radiodensity of less than 10 HU is rather fatty in composition and almost certainly a benign adrenal adenoma. Cone ...
Bosman, F. T. (1999). "The hamartoma-adenoma-carcinoma sequence". The Journal of Pathology. 188 (1): 1-2. doi:10.1002/(SICI) ...
Colorectal adenocarcinoma is distinguished from a colorectal adenoma (mainly tubular and ⁄or villous adenomas) mainly by ... Precancer - Colorectal villous adenoma A lesion at least "high grade intramucosal neoplasia" (high grade dysplasia) has: Severe ... "Colorectal Adenoma Containing Invasive Adenocarcinoma". Stanford University School of Medicine. Finlay A Macrae. "Overview of ... Cancer - Histopathologic image of colonic carcinoid Precancer - Tubular adenoma (left of image), a type of colonic polyp and a ...
In rare cases, however, some adrenal adenomas may become activated. When activated, the adenoma begins to produce hormones in ... Adrenal adenomas are benign tumors of the adrenal gland. In most cases, the tumors display no symptoms and require no treatment ... "Adenoma of the Adrenal Gland". Genetic and Rare Diseases Information Center(GARD) - an NCATS Program. U.S National Library of ... Most people with the disorder have a single adenoma. This form of the syndrome, known as Cushing's disease Forbis P (2005). ...
Pickerill, H P. (1951). "Sebaceoma Nasi, Adenoma Sebaceum (Rhinophyma)." The New Zealand Medical Journal50 (279): 502-3. ...
... known respectively as a single adenoma or double adenoma. Typically, no disease is linked to the cause. A primary adenoma can ... A parathyroid adenoma is the most common cause of hyperparathyroidism. They are more commonly found in women than in men. In ... The hyperplasia is seen as an enlargement of all four of the parathyroid glands, as opposed to a parathyroid adenoma is viewed ... "Parathyroid adenoma: MedlinePlus Medical Encyclopedia". www.nlm.nih.gov. Retrieved 2015-11-18. Cope, Oliver; Keynes, W. Milo; ...
"Entrez Gene: Thyroid adenoma associated". Retrieved 2013-06-10. v t e (Genes on human chromosome 2, All stub articles, Human ... Thyroid adenoma associated is a protein in humans that is encoded by the THADA gene. GRCh38: Ensembl release 89: ...
Sometimes it is used to treat Cushing's syndrome due to pituitary adenoma or Simmond's disease It is also applied in ... List of surgeries by type Jaffe, CA (2006). "Clinically non-functioning pituitary adenoma". Pituitary. 9 (4): 317-21. doi: ...
Parathyroid adenoma (PA) is the most common cause of primary hyperparathyroidism. Ectopic parathyroid adenoma is rare. The ... An adenoma may undergo cystic degeneration. It is important to note that papillary carcinoma may mimic a benign-looking cyst. ... Intra-thyroid parathyroid adenomas mimic thyroid nodules in CT scans and may even show uptake on a thyroid iodine scan. ... Elevated FNA-iPTH measurement, as compared to serum iPTH, is considered positive and diagnostic of parathyroid adenoma. Thyroid ...
Summary: Associated Cancers: colorectal and ovarian cancer; pilomatrixoma; medulloblastoma; pleomorphic adenomas; malignant ... pleomorphic adenomas, and malignant mesothelioma. While less is known about the exact mechanism of α-catenin, its presence in ... "The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the β-catenin signaling pathway". ...
... "adenoma sebaceum" from Félix Balzer's phrase "adénomes sébacés". The papules were in fact neither adenoma nor derived from ... President of the dermatology section of the Royal Society of Medicine Pringle, JJ (1890). "A case of congenital adenoma ... JJ Pringle is primarily remembered for the eponym: Pringle's Adenoma Sebaceum. Now known as facial angiofibroma, this papular ... physicians would recognize that the combination of adenoma sebaceum, epilepsy and learning disability was diagnostic for ...
A Hürthle cell adenoma or a minimally invasive tumor can be treated by a thyroid lobectomy, although some surgeons will perform ... Hürthle cell adenomas are most likely diagnosed much more frequently than Hürthle cell carcinomas. The female to male ratio for ... Adenoma Oncocytoma Oxyphil cell "Endocrine Pathology". Retrieved 2009-05-07. Grani, Giorgio; Lamartina, Livia; Durante, Cosimo ... As expected, patients with carcinoma usually present larger tumors than patients with adenoma. Rarely, the cancer can spread to ...
Moreover, significantly lower levels of HNF-1α in pancreatic tumors and hepatocellular adenomas than in normal adjacent tissues ... as well as hepatocellular adenoma. HNF-1 protein is present in clear cell carcinoma of ovary. In humans, mutations in HNF1A ... "Bi-allelic inactivation of TCF1 in hepatic adenomas". Nature Genetics. 32 (2): 312-5. doi:10.1038/ng1001. PMID 12355088. S2CID ... "Genotype phenotype classification of hepatocellular adenoma". World Journal of Gastroenterology. 13 (19): 2649-54. doi:10.3748/ ...
... adenoma of the sebaceous glands of the face and scalp). The term has since proved to be incorrect as they are neither adenoma ... Pringle's adenoma sebaceum would become a common eponym for the facial rash. 1901 Italian physician GB Pellizzi studied the ... 1885 French dermatologists François Henri Hallopeau and Émile Leredde published a case of adenoma sebaceum that was of a hard ... Vogt's triad of epilepsy, idiocy, and adenoma sebaceum held for 60 years until research by Manuel Gómez discovered that fewer ...
A benign pituitary adenoma was found, which was responsible for the enormous growth. Dr. Oskar Hirsch removed the adenoma. ...
Adenoma is the most common colorectal polyp. Adenomas are not malignant, but rarely adenocarcinoma can develop from them. Large ... villous adenoma, poor anal hygiene[citation needed] Rare causes include: sexually transmitted diseases (e.g. syphilis, rectal ... adenomas can cause rectal bleeding, mucus discharge, tenesmus, and a sensation of urgency. Mucus production may be so great ...
It is important that other tumors such as pleomorphic adenoma, basal cell adenoma, adenoid cystic carcinoma, and teratoma be ... It has previously been referred to as congenital basal cell adenoma, embryoma, or basaloid adenocarcinoma. It is an extremely ... Seifert, G.; Donath, K. (1997). "The congenital basal cell adenoma of salivary glands. Contribution to the differential ... "congenital pleomorphic adenoma"). A clinicopathologic, immunohistochemical and ultrastructural study of nine cases". Am J Surg ...
Chandan Jyoti Das, Ashu Seith, Shivanand Gamanagatti, Ravinder Goswami (2006). "Ectopic Pituitary Adenoma with an Empty Sella ...
"PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using ... "Entrez Gene: PLAG1 pleiomorphic adenoma gene 1". Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML (May 2002 ... Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is ... Voz ML, Agten NS, Van de Ven WJ, Kas K (2000). "PLAG1, the main translocation target in pleomorphic adenoma of the salivary ...
Adrenal tumor subtypes include adrenal adenomas that produce 11-deoxycorticosterone (DOC) leading to increased ... "A case of deoxycorticosterone-producing adrenal adenoma". Endocrine Journal. 42 (5): 637-642. doi:10.1507/endocrj.42.637. ISSN ...
Pituitary adenoma compression may cause LGN degeneration. Lesions affecting the anterior or lateral choroidal arteries may ... "Pituitary Adenoma Causing Compression of the Optic Chiasm". eyerounds.org. "Craniopharyngioma". NORD (National Organization for ... Compression of the optic chiasm is associated with pituitary adenoma, Craniopharyngioma, Meningioma etc. A lesion involving ... "Measuring degeneration of the lateral geniculate nuclei from pituitary adenoma compression detected by 7T ultra-high field MRI ...
... hepatocellular adenoma does occur in men. This study aimed to correlate immunological, histopathological, and molecular ... B-catenin activated adenoma with CTNNB1 exon 3 mutation (Bex3HCA, 8%), B-catenin activated adenoma with CTNNB1 exon 7/8 ... B-catenin activated inflammatory adenoma with CTNNB1 exon 7/8 mutation (Bex7,8IHCA, 5%) and sonic hedgehog adenoma (sh-HCA, 4 ... Hepatocellular adenoma (HCA) is a benign liver tumour, occurring predominantly in females, but sporadically in males. The ...
An aldosterone-producing adenoma is a noncancerous (benign) tumor that develops in an adrenal gland, which is a small hormone- ... Aldosterone-producing adenomas are caused by mutations in one of several genes. The most commonly mutated gene is KCNJ5, ... An aldosterone-producing adenoma is a noncancerous (benign) tumor that develops in an adrenal gland, which is a small hormone- ... Aldosterone-producing adenomas are generally not inherited but arise from a mutation in the bodys cells that occurs after ...
encoded search term (Sebaceous Adenoma) and Sebaceous Adenoma What to Read Next on Medscape ... Sebaceous Adenoma Differential Diagnoses. Updated: Aug 05, 2019 * Author: Nicole Ufkes; Chief Editor: William D James, MD more ... Sebaceous cell adenoma. Rare intra-oral occurrence of a tumour which is a frequent marker of Torres syndrome. Pathology. 1987 ... Sia PI, Rajak S, James C, Huilgol S, Selva D. Sebaceous adenomas in the absence of Muir-Torre syndrome. Can J Ophthalmol. 2016 ...
Hepatic adenomas are a rare benign tumour of the liver, which may present with hepatomegaly or other symptoms. Breast adenomas ... An adenoma is a benign tumor of epithelial tissue with glandular origin, glandular characteristics, or both. Adenomas can grow ... Over time adenomas may transform to become malignant, at which point they are called adenocarcinomas. Most adenomas do not ... Bronchial adenomas are adenomas in the bronchi. They may cause carcinoid syndrome, a type of paraneoplastic syndrome. A ...
Growth Hormone-Secreting Pituitary Adenoma, ACTH-Secreting Pituitary Adenoma, Thyrotroph Adenoma, TSH-Secreting Adenoma, ... Pituitary Adenoma, Pituitary Neoplasm, Functionless Pituitary Adenoma, Non-Functioning Pituitary Adenoma, Secretory Pituitary ... Adenoma, Pituitary Macroadenoma, Pituitary Microadenoma, Pituitary Incidentaloma, Prolactinoma, Prolactin-Secreting Pituitary ... Corticotroph adenoma, ACTH-secreting pituitary adenoma, Corticotroph adenoma (disorder), ACTH secreting adenoma, adenoma, ACTH ...
... including pituitary adenomas. Learn about symptoms and treatment options here. ... Pituitary adenoma causes The causes of pituitary adenomas are still unclear. Tumors in general typically form as a result of ... functioning pituitary adenomas. Pituitary adenomas, which are significantly more common than malignant (cancerous) tumors, can ... Signs of a pituitary adenoma. The signs of a pituitary adenoma can vary considerably based on the tumors size, precise ...
What are tubular adenomas, tubulovillous adenomas, and villous adenomas?. Adenomas can have several different growth patterns ... Many adenomas have a mixture of both growth patterns, and are called tubulovillous adenomas. Most adenomas that are small (less ... Larger adenomas may have a villous growth pattern. Larger adenomas more often have cancers developing in them. Adenomas with a ... What does it mean if I have an adenoma (adenomatous polyp), such as a sessile serrated adenoma or traditional serrated adenoma? ...
Flat adenomas are more difficult to detect and have more aggressive pathology than the typical raised type of polyp detected ... smoking was found to have a strong association with the presence of flat adenomas (precancerous polyps) in the colon and may ... Not only was smoking associated with all flat adenomas, it was also a risk factor for those patients who only had flat adenomas ... Flat nonpolypoid adenomas are considered to be more aggressive than polypoid (raised) adenomas. Therefore, it is recommended ...
Van Gompel explains the importance of timely treatment by surgeons experienced with ACTH-secreting adenomas. Managing these ... Van Gompel explains the importance of timely treatment by surgeons experienced with ACTH-secreting adenomas. ...
Focused Middle Ear Adenoma with stained slides of pathology. ... Middle Ear Adenoma. High Quality Pathology Images of Head & ...
CircVPS13C promotes pituitary adenoma growth by decreasing the stability of IFITM1 mRNA via interacting with RRBP1 *Weiyu Zhang ... Pituitary adenomas (PAs) are one of the most common intracranial tumors, which can result in significant morbidity and can ... Celastrol Induces Apoptosis and Autophagy via the AKT/mTOR Signaling Pathway in the Pituitary ACTH-secreting Adenoma Cells *Zhi ... The genome-wide mutational landscape of pituitary adenomas. *Zhi-Jian Song1 na1, ...
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Cite this page: Pernick N. Pleomorphic adenoma-eyelid. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ ...
A perianal adenoma is a common tumor that arises from the sebaceous glands surrounding the anus. Learn about symptoms, high- ... A perianal adenoma (also known as circumanal adenoma and hepatoid adenoma) is a common tumor that arises from the sebaceous ... some perianal adenomas can be classified into an intermediate category called invasive perianal adenoma. These tumors can act ... Perianal adenomas appear as slow-growing, non-painful masses around the anus. They usually emerge in the hairless area of the ...
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We report a case of water-clear cell adenoma associated with primary hyperparathyroidism. A 59-year-old woman with a history of ... Water-clear cell adenoma associated with primary hyperparathyroidism: report of a case. *Keigo Murakami. 1, ... Liang Y, Mojica W, Chen F. Water-clear cell adenoma of parathyroid gland: a case report and literature review. N Am J Med Sci. ... Water-clear cell adenoma of the parathyroid. A case report with immunohistochemistry and electron microscopy. Arch Pathol Lab ...
... as a target for drug therapy of GH-secreting pituitary adenomas. Aim of this study was to investigate the direct effects of ... metformin, which causes AMPK activation in different cell types, on rat pituitary adenoma cell gr … ... Effects of metformin on cell growth and AMPK activity in pituitary adenoma cell cultures, focusing on the interaction with ... on rat pituitary adenoma cell growth and on related cell signalling pathways. Our results suggest that metformin can exert a ...
Sophorolipid-mediated inhibition of adenoma development in familial adenomatous polyposis syndrome Author: Callaghan, Breedge ...
Sebaceous adenomas are small, yellow bumps containing sweat glands which are usually found on the face. ...
Superadded aspergillosis on carcinoid bronchial adenoma leading to delayed diagnosis.. Postgraduate Medical Journal 1990;66:938 ...
Keywords: Notch1, pleomorphic adenoma, cell differentiation, immunohistochemistry Introduction. Pleomorphic adenoma (PA) is the ... 1. Eveson JW, Kusafuka K, Stenman G, Nagano T. Pleomorphic adenoma. In: (ed.) Barnes L, Eveson JW, Reichart P, Sidransky D. ... Ihrler S, Schwarz S, Zengel P, Guntinas-Lichius O, Kirchner T, Weiler C. Pleomorphic adenoma: Pitfalls and clinicopathological ... Notch as a Possible Cell Differentiation Factor in Pleomorphic Adenomas Keisuke Takamine1, Yukiko Ueda1, Keisuke Nakano1, 2, ...
Sequential MR enhancement pattern in normal pituitary gland and in pituitary adenoma.. W T Yuh, D J Fisher, H D Nguyen, E T ... These results suggest that pituitary adenomas have a direct arterial blood supply, similar to that of the posterior pituitary ... PURPOSE To measure and evaluate the temporal enhancement characteristics of the normal pituitary gland and pituitary adenoma. ... METHODS Thirty healthy subjects and 10 patients with sellar pituitary adenomas were studied prospectively using dynamic MR ...
This revealed a synchronous colonic adenoma in four patients (36%), three of which were tubulovillous adenomas and therefore ... Unfortunately, Murray et al provide no follow up data relating to the duodenal adenomas in their series. We have clinical data ... We read with great interest Murray et als article concerning the association between sporadic duodenal adenoma and colorectal ... We have also noted a lack of published literature regarding sporadic duodenal adenomas, with the exception of the two reports ...
high-risk adenoma. LRA. low-risk adenoma. MRA. medium-risk adenoma. NPV. negative predictive value. PPV. positive predictive ... medium-risk adenomas, low-risk adenomas, benign polyps, and no findings on a colonoscopy). ... Stool-derived eukaryotic RNA biomarkers for detection of high-risk adenomas. Erica Barnell, Yiming Kang, Andrew Barnell, View ... Stool-derived eukaryotic RNA biomarkers for detection of high-risk adenomas Message Subject (Your Name) has forwarded a page to ...
Background/aims Sebaceous adenomas (SAs) are rare, benign sebaceous gland tumours of the eyelid. SAs may be associated with ...
adenoma. + pituitary. [2]. View: Monthly list ✔ Monthly list ✔ Monthly calendar ✔ Weekly list ...
Tags: adenoma, anesthesia, benign tumor, blood tests, calcium, Dr. Michael Yeh, Endocrine, Endocrine Surgery, endocrinologist, ... Through an Ultrasound, my endocrinologist found a suspicious mass that was later determined to be an adenoma (a benign tumor). ...
... who undergo colonoscopy have a similar adenoma detection rate to those aged 50-59 years without DM. ... DDW: Diabetes Linked to Higher Adenoma Detection in 40s * Share on Facebook ... The researchers found that the adenoma detection rate was 14.4, 30.4, and 32% in those aged 40-49 without DM, 40-49 years with ... Compared to 40- to 49-year-olds without DM, the adenoma detection rate was significantly higher for those aged 40-49 with DM ( ...
Its reports state that I have adenoma in my pituitary gland as big as a pea. Can this be the cause of hearing loss? I am a ... Is non-functioning pituitary adenoma the cause of my hearing loss?. Answered by: Dr (Prof) Santosh Kacker , Senior Consultant, ... Its reports state that I have adenoma in my pituitary gland as big as a pea. Can this be the cause of hearing loss? I am a ... It is not related to non-functioning pituitary adenoma. You can dive or swim. It is not directly related to hearing loss. ...
RESULTS: There were 3305 traditional adenomas and 43 serrated adenomas. Serrated adenomas were more often found in the ... adenoma. METHODS: Colonoscopy records for 1995-1998 were reviewed, and all traditional adenomas and serrated adenomas ... AIM: Serrated adenoma is a recently described category of colorectal adenoma. The aim of this study was to determine whether ... Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma. ...

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