Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)Herb-Drug Interactions: The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.World Health Organization: A specialized agency of the United Nations designed as a coordinating authority on international health work; its aim is to promote the attainment of the highest possible level of health by all peoples.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Air: The mixture of gases present in the earth's atmosphere consisting of oxygen, nitrogen, carbon dioxide, and small amounts of other gases.Lung Neoplasms: Tumors or cancer of the LUNG.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Health Knowledge, Attitudes, Practice: Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).SingaporePatient Discharge: The administrative process of discharging the patient, alive or dead, from hospitals or other health facilities.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Eyelid DiseasesRegistries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Eyelid Neoplasms: Tumors of cancer of the EYELIDS.Ophthalmology: A surgical specialty concerned with the structure and function of the eye and the medical and surgical treatment of its defects and diseases.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Skin Neoplasms: Tumors or cancer of the SKIN.Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Veterinarians: Individuals with a degree in veterinary medicine that provides them with training and qualifications to treat diseases and injuries of animals.Surgery, Veterinary: A board-certified specialty of VETERINARY MEDICINE, requiring at least four years of special education, training, and practice of veterinary surgery after graduation from veterinary school. In the written, oral, and practical examinations candidates may choose either large or small animal surgery. (From AVMA Directory, 43d ed, p278)Ear: The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Ear, Inner: The essential part of the hearing organ consists of two labyrinthine compartments: the bony labyrinthine and the membranous labyrinth. The bony labyrinth is a complex of three interconnecting cavities or spaces (COCHLEA; VESTIBULAR LABYRINTH; and SEMICIRCULAR CANALS) in the TEMPORAL BONE. Within the bony labyrinth lies the membranous labyrinth which is a complex of sacs and tubules (COCHLEAR DUCT; SACCULE AND UTRICLE; and SEMICIRCULAR DUCTS) forming a continuous space enclosed by EPITHELIUM and connective tissue. These spaces are filled with LABYRINTHINE FLUIDS of various compositions.Veterinary Medicine: The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.Ear, Middle: The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.Ear, External: The outer part of the hearing system of the body. It includes the shell-like EAR AURICLE which collects sound, and the EXTERNAL EAR CANAL, the TYMPANIC MEMBRANE, and the EXTERNAL EAR CARTILAGES.Cat Diseases: Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.Horseshoe Crabs: An arthropod subclass (Xiphosura) comprising the North American (Limulus) and Asiatic (Tachypleus) genera of horseshoe crabs.Newfoundland and Labrador: Province of Canada consisting of the island of Newfoundland and an area of Labrador. Its capital is St. John's.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Ear Canal: The narrow passage way that conducts the sound collected by the EAR AURICLE to the TYMPANIC MEMBRANE.Otitis Externa: Inflammation of the OUTER EAR including the external EAR CANAL, cartilages of the auricle (EAR CARTILAGE), and the TYMPANIC MEMBRANE.Ear Auricle: The shell-like structure projects like a little wing (pinna) from the side of the head. Ear auricles collect sound from the environment.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Ear Neoplasms: Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Carcinoma, Adenoid Cystic: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)Salivary Glands: Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).Adenoma, Pleomorphic: A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)Salivary Glands, Minor: Accessory salivary glands located in the lip, cheek, tongue, floor of mouth, palate and intramaxillary.Carcinoma, Mucoepidermoid: A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)Salivary Gland DiseasesParotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Adenolymphoma: A benign tumor characterized histologically by tall columnar epithelium within a lymphoid tissue stroma. It is usually found in the salivary glands, especially the parotid.Submandibular Gland: One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. The secretory units are predominantly serous although a few mucous alveoli, some with serous demilunes, occur. (Stedman, 25th ed)Lymphoma, B-Cell, Marginal Zone: Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.Parotid Gland: The largest of the three pairs of SALIVARY GLANDS. They lie on the sides of the FACE immediately below and in front of the EAR.Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Rhinoscleroma: A granulomatous disease caused by KLEBSIELLA RHINOSCLEROMATIS infection. Despite its name, this disease is not limited to the nose and NASOPHARYNX but may affect any part of the RESPIRATORY TRACT, sometimes with extension to the lip and the skin.Submandibular Gland NeoplasmsMikulicz' Disease: A chronic, benign, and usually painless inflammatory swelling of the lacrimal and salivary glands. It is considered by some to include the glandular enlargement associated with other diseases, such as Sjogren's syndrome, sarcoidosis, lupus erythematosus, etc.Tympanic Membrane: An oval semitransparent membrane separating the external EAR CANAL from the tympanic cavity (EAR, MIDDLE). It contains three layers: the skin of the external ear canal; the core of radially and circularly arranged collagen fibers; and the MUCOSA of the middle ear.Spinal Canal: The cavity within the SPINAL COLUMN through which the SPINAL CORD passes.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Stapes: One of the three ossicles of the middle ear. It transmits sound vibrations from the INCUS to the internal ear (Ear, Internal see LABYRINTH).OcimumEugenol: A cinnamate derivative of the shikamate pathway found in CLOVE OIL and other PLANTS.Oils, Volatile: Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.SesquiterpenesProteus mirabilis: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that is frequently isolated from clinical specimens. Its most common site of infection is the urinary tract.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Monoterpenes: Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).Ocimum basilicum: A plant species of the genus OCIMUM, family LAMIACEAE. It is a condiment with carminative properties.Camphor: A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.Sesquiterpenes, Germacrane: SESQUITERPENES cyclized to one 10-carbon ring.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Plasma Cells: Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)Textbooks as Topic: Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.Hypercalcemia: Abnormally high level of calcium in the blood.Orthopedics: A surgical specialty which utilizes medical, surgical, and physical methods to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures.Internal Medicine: A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.Whole-Body Irradiation: Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
(1/35) Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma.

AIMS: Regulation of cell cycle progression is a fundamental control process, linked to cellular differentiation and apoptosis in normal tissues. p21(WAF1) is a nuclear protein that regulates cell cycle progression. p21(WAF1) can be transcriptionally upregulated by p53, but may be activated independently of p53-for example, during terminal differentiation. Loss of topological control of p21(WAF1) expression is an early feature of malignancy in the colorectal system. Similar to the colonic mucosa, sebaceous glands contain cells that are constantly going through a process of cell division, differentiation, and cell death. This study investigated the expression of p53, p21(WAF1), and the proliferation marker Ki67 in normal sebaceous glands, sebaceous adenoma, sebaceoma, and sebaceous carcinoma. METHODS: Serial sections were stained with monoclonal antibodies to p21(WAF1), p53, and Ki67 (MIB1) using standard immunohistochemical techniques. RESULTS: In normal sebaceous glands, p21(WAF1) positive cells were only seen within the differentiating compartment, which was spatially distinct from the cycling peripheral Ki67 positive cells. In sebaceous adenoma and sebaceoma, topological control was maintained, with the distribution of markers being similar to that seen in normal sebaceous glands. Loss of topological control of markers of cellular control was seen in sebaceous carcinoma only. This contrasts with colonic tumours, in which loss of p21 compartmentalisation is seen in adenomas at an early stage of tumour progression. CONCLUSION: This work confirms the hypothesis that the dysregulation of cell cycle progression is an important process in the development of malignancy within sebaceous glands, although loss of topological control was seen only in sebaceous carcinoma.  (+info)

(2/35) Immunohistochemical staining for adipophilin, perilipin and TIP47.

BACKGROUND: The presence of lipid in the cell cytoplasm is useful for supporting the diagnosis of sebaceous gland carcinoma (SGC). Currently this requires histochemical stains that are carried out on frozen sections of unprocessed tissue. Recently, several anti-adipocytic antibodies that recognise proteins associated with lipid vesicles have been described. These antibodies can be applied to paraffin-wax sections. AIM: To assess the ability of anti-adipocytic antibodies to identify intracytoplasmic lipid in SGC. METHODS: Immunohistochemistry with a monoclonal antibody to adipophilin and polyclonal antibodies to perilipin and TIP47/PP17 was carried out on archival, formalin-fixed, paraffin-wax-embedded sections of 26 samples of SGC. The immunostaining was compared with 22 other eyelid tumours (11 basal cell carcinomas (BCC), 10 squamous cell carcinomas (SCC) and 1 Merkel cell tumour). RESULTS: Immunohistochemical staining was positive in 23, 10 and 2 cases of 26 SGC with adipophilin, perilipin and TIP47, respectively. The positive staining identified cytoplasmic lipid vesicles. Anti-adipophilin was positive in five other eyelid tumours (4 BCC and 1 SCC) staining small cytoplasmic granules that can be easily distinguished from the staining in SGC. CONCLUSIONS: Immunohistochemical staining for adipophilin and perilipin is a useful ancillary technique for the demonstration of lipid in SGC that may be applied to paraffin-wax sections.  (+info)

(3/35) Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia.

AIM: To determine the complications associated with mitomycin C (MMC) in the treatment of ocular surface neoplasia. METHODS: A retrospective and consecutive study of 100 eyes in 91 patients with ocular surface neoplasia treated with MMC in a single centre between November 1998 and January 2005. Outcome measures included complications of MMC and the treatment required for these complications. RESULTS: One to three 7 day cycles of topical MMC 0.04% four times a day were given to 59 eyes with localised corneal-conjunctival intraepithelial neoplasia (CIN), 19 eyes with diffuse CIN, six eyes with recurrent CIN, one eye with ocular surface squamous cell carcinoma, three eyes with primary acquired melanosis (PAM) with atypia, nine eyes with conjunctival malignant melanoma (MM), two eyes with sebaceous carcinoma with pagetoid spread, and one eye with recurrent atypical fibroxanthoma. Nine patients had bilateral CIN. 31 (34%) cases developed an allergic reaction to MMC and 14 (14%) eyes had epiphora secondary to punctal stenosis at a mean follow up period of 26.5 months. CONCLUSION: In the largest study looking at complications of topical MMC in the treatment of ocular surface neoplasia, allergic reaction and punctal stenosis are relatively common. Serious complications were not observed suggesting the safe use of MMC in mid-term follow up.  (+info)

(4/35) Activator protein-1 activity regulates epithelial tumor cell identity.

To examine the consequences of inhibiting activator protein-1 (AP-1) transcription factors in skin, transgenic mice were generated, which use the tetracycline system to conditionally express A-FOS, a dominant negative that inhibits AP-1 DNA binding. Older mice develop mild alopecia and hyperplasia of sebaceous glands, particularly around the eyes. When A-FOS was expressed during chemical-induced skin carcinogenesis, mice do not develop characteristic benign and malignant squamous lesions but instead develop benign sebaceous adenomas containing a signature mutation in the H-ras proto-oncogene. Inhibiting AP-1 activity after tumor formation caused squamous tumors to transdifferentiate into sebaceous tumors. Furthermore, reactivating AP-1 in sebaceous tumors results in a reciprocal transdifferentiation into squamous tumors. In both cases of transdifferentiation, individual cells express molecular markers for both cell types, indicating individual tumor cells have the capacity to express multiple lineages. Molecular characterization of cultured keratinocytes and tumor material indicates that AP-1 regulates the balance between the wnt/beta-catenin and hedgehog signaling pathways that determine squamous and sebaceous lineages, respectively. Chromatin immunoprecipitation analysis indicates that c-Jun binds several wnt promoters, which are misregulated by A-FOS expression, suggesting that members of the wnt pathway can be a primary targets of AP-1 transcriptional regulation. Thus, AP-1 activity regulates tumor cell lineage and is essential to maintain the squamous tumor cell identity.  (+info)

(5/35) A clinicopathological study of eyelid malignancies from central India.

BACKGROUND: Eyelid malignancies are completely treatable if detected early. The treatment depends on the invasiveness of the cancer which in turn depends on the type of malignancy. AIM: The aim of the study was to characterize the distribution of the types of eyelid malignancies in central India. SETTINGS AND DESIGN: The study was conducted in the Department of Plastic and Maxillofacial Surgery at a tertiary care hospital. MATERIALS AND METHODS: We report a series of 27 cases of eyelid malignancies. In the same case series, we also include a case of malignant hemangiopericytoma which is an extremely rare form of eyelid malignancy worldwide. STATISTICAL ANALYSIS: Depending on the underlying statistical distribution, either analysis of variance (ANOVA) or the Kruskal-Wallis (K-W) test was used to assess the differential distribution of these variables across the types of eyelid malignancies observed in this study. RESULTS: We observed that sebaceous cell carcinoma (approximately 37%) was almost as prevalent as basal cell carcinoma (approximately 44%) in the study subjects and had an earlier age of occurrence and a more rapid clinical course. CONCLUSIONS: Sebaceous cell carcinoma of the eyelid is almost as common as basal cell carcinoma in a large tertiary care centre in central India.  (+info)

(6/35) Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type.

The NH(2) terminus of LEF1 is frequently mutated in human sebaceous tumors. To investigate how this contributes to cancer, we did two-stage chemical carcinogenesis on K14DeltaNLef1 transgenic mice, which express NH(2)-terminally truncated Lef1 in the epidermal basal layer. Transgenic mice developed more tumors, more rapidly than littermate controls, even without exposure to tumor promoter. They developed sebaceous tumors, whereas controls developed squamous cell carcinomas. K14DeltaNLef1 epidermis failed to up-regulate p53 and p21 proteins during tumorigenesis or in response to UV irradiation, and this correlated with impaired p14ARF induction. We propose that LEF1 NH(2)-terminal mutations play a dual role in skin cancer, specifying tumor type by inhibiting Wnt signaling and acting as a tumor promoter by preventing induction of p53.  (+info)

(7/35) Role of fine needle aspiration cytology in diagnosis of eyelid sebaceous carcinoma.

Sebaceous carcinoma of the ocular adnexa is a malignant neoplasm which can exhibit aggressive local behavior and can metastasize to regional lymph nodes and distant organs. The neoplasm is known to masquerade as other benign and less malignant lesions, resulting in delay in diagnosis and relative high morbidity and mortality. Fine needle aspiration cytology (FNAC) of recurrent upper eyelid nodules treated elsewhere as chalazion was done. Cytological smears were suggestive of malignancy. Subsequently histopathology confirmed the diagnosis of sebaceous gland carcinoma. Eyelid reconstruction was done after histopathologically confirmed tumor-free margins. The article highlights the role of FNAC in early diagnosis and subsequent appropriate surgical management of eyelid sebaceous gland carcinoma to prevent recurrence and metastasis.  (+info)

(8/35) Adnexal skin tumors in Zaria, Nigeria.

BACKGROUND: Adnexal skin tumors share many features in common and differentiate along one line. Their detailed morphological classification is difficult because of the variety of tissue elements and patterns seen. They may be clinically confused with other cutaneous tumors. The aim of this report is to review and classify all adnexal tumors seen in a pathology department over a 16-year period. METHOD: A 16-year retrospective analysis of all adnexal skin tumors seen in a large University Teaching Hospital in Nigeria from January 1991- December 2006. All tissue specimens were fixed in 10% formalin, processed in paraffin wax and stained with Haematoxylin and Eosin. Histology slides were retrieved, studied and lesions characterized. RESULTS: Fifty-two adnexal tumors were seen, accounting for 0.9% of all cutaneous tumors seen within the same period. The median age was 33 years (range: 4 days-70 years). Clinical presentations varied from discreet swellings and nodules to ulcerated masses. Five patients presented with recurrent lesions. Only two cases had a clinical diagnosis of adnexal tumor. Twenty-four (46%) of the lesions were distributed in the head and neck region. Duration of symptoms was 2 months to 15 years (median: 12 months). Tumours of the sweat gland were the commonest--41 (78.8%); they comprised predominantly eccrine acrospiroma (17), characterized histologically by solid nests of round to polygonal cells with clear to eosinophilic cytoplasm, forming tubules in areas. Tumours of sebaceous gland were 7 (13.5%); they comprised mainly Nevus sebaceous of Jadassohn (6), composed of immature sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma. Tumours of hair follicle were 4 (7.7%) and included trichoepithelioma, characterized microscopically by multiple horn cysts and epithelial tracts connecting abortive pilar structures and a trichofolliculoma. Forty-six lesions (88.5%) were benign and six (11.5%) malignant. CONCLUSION: Adnexal skin tumors have distinct histological patterns which differentiates them from other cutaneous tumors. They are commonly distributed in the head, neck and trunk. The commonest variants are those of eccrine sweat gland origin. Malignant adnexal tumors are uncommon in our setting.  (+info)

*  Salivary gland tumour
... not otherwise specified Basal cell adenocarcinoma Sebaceous carcinoma Sebaceous lymphadenocarcinoma Cystadenocarcinoma Low- ... not otherwise specified Adenocarcinoma, not otherwise specified Myoepithelial carcinoma Carcinoma ex pleomorphic adenoma ... grade cribriform cystadenocarcinoma Mucinous adenocarcinoma Oncocytic carcinoma Salivary duct carcinoma Salivary duct carcinoma ... epithelial tumors Acinic cell carcinoma Mucoepidermoid carcinoma Adenoid cystic carcinoma Polymorphous low-grade adenocarcinoma ...
*  List of MeSH codes (C04)
... adenocarcinoma, sebaceous MeSH C04.557.470.550.175 --- adenoma, sweat gland MeSH C04.557.470.550.175.125 --- acrospiroma, ... adenocarcinoma, sebaceous MeSH C04.557.470.200.025.152 --- adrenocortical carcinoma MeSH C04.557.470.200.025.200 --- carcinoid ... adenocarcinoma, bronchiolo-alveolar MeSH C04.557.470.200.025.045 --- adenocarcinoma, clear cell MeSH C04.557.470.200.025.060 ... adenocarcinoma, mucinous MeSH C04.557.470.200.025.085 --- adenocarcinoma, papillary MeSH C04.557.470.200.025.085.225 --- ...
*  International Classification of Diseases for Oncology
M8410/0 Sebaceous adnoma (C44._) M8410/3 Sebaceous adenocarcinoma (C44._) Sebaceous carcinoma M8413/3 Eccrine adenocarcinoma ( ... Basophil adenocarcinoma Mucoid cell adenocarcinoma M8310/0 Clear cell adenoma M8310/3 Clear cell adenocarcinoma, NOS Clear cell ... M8140/2 Adenocarcinoma in situ, NOS (M8140/3) Adenocarcinoma, NOS M8140/6 Adenocarcinoma, metastatic, NOS M8141/3 Scirrhous ... Parietal cell adenocarcinoma M8215/3 Adenocarcinoma of anal glands (C21.1) Adenocarcinoma of anal ducts M8220/0 Adenomatous ...
*  Ovarian cancer
Low-grade serous adenocarcinomas resemble Fallopian tube epithelium, whereas high-grade serous adenocarcinomas show anaplasia ... sebaceous tumor, and struma ovarii can also be part of the dermoid cyst. They are treated with surgery and adjuvant platinum ... Mucinous tumors include mucinous adenocarcinoma and mucinous cystadenocarcinoma. Mucinous adenocarcinomas make up 5-10% of ... Clear-cell adenocarcinomas are histopathologically similar to other clear cell carcinomas, with clear cells and hobnail cells. ...
*  Familial adenomatous polyposis
... sebaceous cysts, and osteomata (benign bone tumors). The combination of polyposis, osteomas, fibromas and sebaceous cysts is ... particularly ampullary adenocarcinoma). Other signs that may point to FAP are pigmented lesions of the retina ("CHRPE- ...
*  MiR-203
It also was expressed at high levels in differentiating cells such as hair follicles, epidermis and sebaceous glands. Wei et al ... miR-203 has been found overexpressed in pancreatic adenocarcinoma and shows correlation with poor prognosis in patients that ... "MicroRNA-203 Expression as a New Prognostic Marker of Pancreatic Adenocarcinoma". Ann Surg Oncol. 17 (12): 3120-8. doi:10.1245/ ...
*  Hyperplasia
Sebaceous hyperplasia - In this condition, small yellowish growths develop on the skin, usually on the face. This condition is ... The development of endometrial adenocarcinoma from endometrial hyperplasia is a typical example of how the effects of ... Atypical endometrial hyperplasia may represent an early neoplastic process which can lead to endometrial adenocarcinoma. ...
*  Adenoma
A sebaceous adenoma is a cutaneous condition characterized by a slow-growing tumour usually presenting as a pink, flesh- ... Adenocarcinoma Table 6-5 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology ... at which point they are called adenocarcinomas. Most adenomas do not transform. But even while benign, they have the potential ...
*  Anal gland
Anal sac adenocarcinoma Hyena butter Rosell, F.; Jojola, S. M.; Ingdal, K.; Lassen, B. A.; Swenson, J. E.; Arnemo, J. M.; ... Sebaceous glands within the lining secrete a liquid that is used for identification of members within a species. These sacs are ... This is usually done in the case of recurrent infection or because of the presence of an anal sac adenocarcinoma, a malignant ...
*  Squamous cell carcinoma
Esophageal cancer may be due to either squamous cell carcinoma (ESCC) or adenocarcinoma (EAC). SCCs tend to occur closer to the ... It originates in the pilo-sebaceous glands, and is similar in clinical presentation and microscopic analysis to squamous cell ... mouth, while adenocarcinomas occur closer to the stomach. Dysphagia (difficulty swallowing, solids worse than liquids) and ...
*  List of cutaneous conditions
... sebaceous epithelioma) Sebaceous adenoma Sebaceous carcinoma Sebaceous hyperplasia Sebaceous nevus syndrome Seboacanthoma ... Aggressive digital papillary adenocarcinoma (digital papillary adenocarcinoma, papillary adenoma) Apocrine gland carcinoma ... Nevus comedonicus syndrome Nevus sebaceous (nevus sebaceous of Jadassohn, organoid nevus) Nevus unius lateris Nodular basal ... Within the latter type, the hairs occur in structures called pilosebaceous units, each with hair follicle, sebaceous gland, and ...
*  Sweat gland
Because both apocrine glands and sebaceous glands open into the hair follicle, apocrine sweat is mixed with sebum. It was ... Sweat gland tumors include: Acrospiroma Aggressive digital papillary adenocarcinoma Apocrine gland carcinoma Ceruminoma ... Ceruminous glands are near the ear canals, and produce cerumen (earwax) that mixes with the oil secreted from sebaceous glands ... Structure and Function of Eccrine, Apocrine and Sebaceous Glands (3rd ed.). pp. 539-544. ISBN 978-0723435716. CS1 maint: ...
*  Neoplasm
Cysts (such as sebaceous cysts) are also referred to as tumors, even though they have no neoplastic cells. This is standard in ... "Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma". Int J Clin Exp Pathol ... Benign conditions that are not associated with an abnormal proliferation of tissue (such as sebaceous cysts) can also present ... "Promoter hypermethylation of multiple genes in early gastric adenocarcinoma and precancerous lesions". Hum. Pathol. 40 (11): ...
Rare Cancer Support Forum • Members  Rare Cancer Support Forum • Members
Sebaceous Adenocarcinoma Tue May 15, 2018 8:59 pm. Frantic. 0. left submandibular gland adenocarcinoma Sun Dec 09, 2018 12:54 ... Adenocarcinoma salivary gland Mon Apr 27, 2015 10:54 pm. Clare. 0. Adenoid Cystic Carcinoma of the Salivary Gland Sun Jun 07, ...
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Rare Cancer Support Forum • Members  Rare Cancer Support Forum • Members
Sebaceous Carcinoma Fri Jan 12, 2018 1:32 pm. Lilichka1. 0. Adenocarcinoma metastatic origin breast/ apocrine neoplasm Thu Sep ... Aggresive digital papillary adenocarcinoma Fri Aug 11, 2017 1:12 pm. SallyL. 0. Merkel Cell Carcinoma Mon Jun 19, 2017 6:33 am ... Adenoid Cystic Carcinoma sebaceous gland, right arm Sat Nov 17, 2012 11:27 pm. ... Skin and Sweat & Sebaceous Gland Cancers. digital papillary, eccrine, apocrine, mucinous eccrine, microcystic adenexal ...
more infohttp://www.rare-cancer.org/forum/memberlist.php?g=579&mode=group&sid=33557169bb7370ee58af0e220d6e1c24&sk=c&sd=d
Approach to the Cancer Case: Staging--How and Why - WSAVA2008 - VIN  Approach to the Cancer Case: Staging--How and Why - WSAVA2008 - VIN
Sebaceous adenocarcinoma. Well differentiated mast cell tumours. Multilobular osteoma/osteosarcoma of bone ...
more infohttp://www.vin.com/apputil/content/defaultadv1.aspx?id=3866583&pid=11268
Incidence of eyelid cancers in Singapore from 1968 to 1995 | British Journal of Ophthalmology  Incidence of eyelid cancers in Singapore from 1968 to 1995 | British Journal of Ophthalmology
In this study, sebaceous adenocarcinoma was found to be almost twice as common in females as in males. This preponderance of ... In one particular study over a 22 year period, there were 48.1% of SCC, 32.6% of BCC, and 13.5% of sebaceous adenocarcinoma.12 ... The most common primary malignancy was BCC (84.0%), followed by sebaceous adenocarcinoma (10.2%) and SCC (3.4%) (Table 2). In ... The most common cancer was basal cell carcinoma (84.0%), followed by sebaceous adenocarcinoma (10.2%) and squamous cell ...
more infohttp://bjo.bmj.com/content/83/5/595
Anterior + uveitis (incl posterior uveitis) Flashcards - OPTOM 450 | Brainscape  Anterior + uveitis (incl posterior uveitis) Flashcards - OPTOM 450 | Brainscape
sebaceous gland adeno-carcinoma 121 What characterises a malignant melanoma? (5) irregular borders. fast growing colour changes ...
more infohttps://www.brainscape.com/flashcards/anterior-uveitis-incl-posterior-uveitis-6027779/packs/9169035
melanoma of the cornea drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine  melanoma of the cornea drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-minor] Adenocarcinoma, Sebaceous / drug therapy. Carcinoma in Situ / drug therapy. Carcinoma, Squamous Cell / drug therapy ... two eyes with sebaceous carcinoma with pagetoid spread, and one eye with recurrent atypical fibroxanthoma. ...
more infohttp://www.bmlsearch.com/?kwr=melanoma+of+the+cornea+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1
My cat has a small bump by his ear and his ear is swollen what can I do. Cant afford to take to vet until after the first of...  My cat has a small bump by his ear and his ear is swollen what can I do. Cant afford to take to vet until after the first of...
Skin Cancer (Adenocarcinoma) in Dogs Sweat Gland, Sebaceous Adenocarcinoma in Dogs Adenocarcinoma is a glandular skin cancer ...
more infohttps://www.petmd.com/askpetmd/68/18838
basal cell carcinoma of external ear 2005:2010[pubdate] *count=100 - BioMedLib™ search engine  basal cell carcinoma of external ear 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Sebaceous Gland Neoplasms / pathology. *[MeSH-minor] Adenocarcinoma, Sebaceous / pathology. Aged. Carcinoma, Basal Cell / ... Only two cases of sebaceous neoplasms have been reported in the English literature, a sebaceous carcinoma and a sebaceous ... We highlight the differential diagnosis, particularly sebaceous carcinoma and basal cell carcinoma with sebaceous ... MeSH-minor] Adenocarcinoma / surgery. Aged. Aged, 80 and over. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / ...
more infohttp://www.bmlsearch.com/?kwr=basal+cell+carcinoma+of+external+ear+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Salivary Gland Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] | HealthLink BC  Salivary Gland Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] | HealthLink BC
Sebaceous adenocarcinoma Sebaceous adenocarcinoma is a rare malignant epithelial tumor composed of islands and sheets of cells ... Sebaceous adenoma.. *Sebaceous lymphadenoma. (Refer to the sebaceous lymphadenocarcinoma section in the Cellular Classification ... The carcinoma element may be sebaceous adenocarcinoma or some other specific or nonspecific form of salivary gland cancer.[3] ... Adenocarcinoma, NOS Adenocarcinoma, NOS, is a salivary gland carcinoma that shows glandular or ductal differentiation but lacks ...
more infohttps://www.healthlinkbc.ca/health-topics/ncicdr0000062920
Eye Inflammation (Blepharitis) in Cats | petMD  Eye Inflammation (Blepharitis) in Cats | petMD
Sebaceous adenomas and adenocarcinomas. *Squamous cell carcinoma (white cats). *Mast cell. Other ...
more infohttps://www.petmd.com/cat/conditions/eyes/c_ct_blepharitis
Salivary Gland Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] | Cigna  Salivary Gland Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] | Cigna
Sebaceous adenocarcinoma Sebaceous adenocarcinoma is a rare malignant epithelial tumor composed of islands and sheets of cells ... Sebaceous adenoma.. *Sebaceous lymphadenoma. (Refer to the sebaceous lymphadenocarcinoma section in the Cellular Classification ... The carcinoma element may be sebaceous adenocarcinoma or some other specific or nonspecific form of salivary gland cancer.[3 ] ... Adenocarcinoma, NOS Adenocarcinoma, NOS, is a salivary gland carcinoma that shows glandular or ductal differentiation but lacks ...
more infohttps://www.cigna.com/individuals-families/health-wellness/hw/medical-topics/salivary-gland-cancer-treatment-ncicdr0000062920
Salivary Gland Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] | Cigna  Salivary Gland Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] | Cigna
Sebaceous adenocarcinoma Sebaceous adenocarcinoma is a rare malignant epithelial tumor composed of islands and sheets of cells ... Sebaceous adenoma.. *Sebaceous lymphadenoma. (Refer to the sebaceous lymphadenocarcinoma section in the Cellular Classification ... The carcinoma element may be sebaceous adenocarcinoma or some other specific or nonspecific form of salivary gland cancer.[ 3 ... Adenocarcinoma, NOS Adenocarcinoma, NOS, is a salivary gland carcinoma that shows glandular or ductal differentiation but lacks ...
more infohttps://www.cigna.com/healthwellness/hw/medical-topics/salivary-gland-cancer-treatment-ncicdr0000062920
Injection-Site Sarcoma (Vaccine-Site Sarcoma) in Cats - Page 2 of 3 - PetPlace  Injection-Site Sarcoma (Vaccine-Site Sarcoma) in Cats - Page 2 of 3 - PetPlace
Sebaceous gland adenocarcinoma - malignant tumor derived from glands that empty into hair follicles ... Sebaceous gland adenoma - cat a benign tumor of the glands that empty into the hair follicle ...
more infohttps://www.petplace.com/article/cats/pet-health/injection-site-sarcoma-vaccine-site-sarcoma-in-cats/2/
Search Articles | University of Toronto Libraries  Search Articles | University of Toronto Libraries
Adenocarcinoma, Sebaceous - pathology , Index Medicus ... Background: Sebaceous carcinoma of the eyelid can clinically ... Full Text Histopathological review of sebaceous carcinoma of the eyelid by Pereira, Patricia Rusa and Odashiro, Alexandre Nakao ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=Author:Patricia%20Rusa%20Pereira%20Odashiro
Search Articles | University of Toronto Libraries  Search Articles | University of Toronto Libraries
Adenocarcinoma, Sebaceous - pathology , Index Medicus ... Background: Sebaceous carcinoma of the eyelid can clinically ... 8. Full Text Histopathological review of sebaceous carcinoma of the eyelid by Pereira, Patricia Rusa and Odashiro, Alexandre ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=Author:Odashiro,%20Alexandre%20Nakao&sort=PublicationDate:asc
Ear Tumors in Dogs - PetPlace  Ear Tumors in Dogs - PetPlace
Ceruminous gland adenocarcinoma. These tumors are rare, but they are the most common malignant tumor of the ear canal of dogs, ... Sebaceous gland tumors. They are more common in middle-aged to older dogs than cats, with no sex predilection. They generally ... Ear tumors are growths associated with the dog's ear and the most common include ceruminous gland adenoma or adenocarcinoma, ... Radiation therapy in large or incompletely excised masses (ceruminous gland adenocarcinoma). Home Care and Prevention. Follow ...
more infohttps://www.petplace.com/article/dogs/pet-health/ear-tumors-in-dogs/
Tumors of the Skin  in Dogs - Dog Owners - Merck Veterinary Manual  Tumors of the Skin in Dogs - Dog Owners - Merck Veterinary Manual
Sebaceous gland adenocarcinomas are a rare malignant form of sebaceous gland tumor. They occur in middle-aged or older dogs. ... Sebaceous Gland Tumors. The sebaceous glands secrete the oil known as sebum into the hair follicles and onto the skin. Tumors ... Perianal gland adenocarcinomas are uncommon in dogs. These tumors are found in male dogs 10 times more commonly than in females ... Sebaceous gland overgrowth (hyperplasia) occurs in old dogs and cats. It appears as lumps seldom more than 0.4 inches (1 ...
more infohttp://www.merckvetmanual.com/dog-owners/skin-disorders-of-dogs/tumors-of-the-skin-in-dogs
ICD-10-CM Code C44.191 - Other specified malignant neoplasm of skin of unspecified eyelid, including canthus  ICD-10-CM Code C44.191 - Other specified malignant neoplasm of skin of unspecified eyelid, including canthus
Sebaceous adenocarcinoma of eyelid (disorder) Coding Advice SNOMET-CT * Consider laterality specification ...
more infohttps://icd.codes/icd10cm/C44191
Sebaceous gland synonyms, sebaceous gland antonyms - FreeThesaurus.com  Sebaceous gland synonyms, sebaceous gland antonyms - FreeThesaurus.com
Antonyms for sebaceous gland. 2 synonyms for sebaceous gland: glandulae sebaceae, sebaceous follicle. What are synonyms for ... sebaceous gland. Lower Eyelid Reconstructive Surgery and Resection of Sebaceous Adenocarcinoma in a Dog ... Sebaceous gland tumors are comprised of sebaceous adenoma and sebaceous carcinoma.. Histopathological study of 26 rare skin ... sebaceous gland. Also found in: Dictionary, Medical, Encyclopedia, Wikipedia.. Related to sebaceous gland: sudoriferous gland ...
more infohttp://www.freethesaurus.com/sebaceous+gland
THE MORPHOLOGICAL SPECTRUM OF SALIVARY GLAND TUMOURS AT KEMU AND MAYO HOSPITAL, LAHORE. - Free Online Library  THE MORPHOLOGICAL SPECTRUM OF SALIVARY GLAND TUMOURS AT KEMU AND MAYO HOSPITAL, LAHORE. - Free Online Library
... basal cell adenocarcinomas, sebaceous carcinomas, small cell carcinomas, oncocytic carcinomas, mucinous adenocarcinomas, ... and Adenocarcinoma (NOS) which constituted 4 cases (4.12%) each (Table 1). All 4 adenocarcinomas (NOS) and 3 Ca ex PA's were ... 8. Sebaceous Lymphadenoma###01###0.61###0.38 Total Benign Tumours###162###100###62.55 B - Malignant Tumours (n=97) Histological ... 4. Adenocarcinoma NOS###04###4.12###1.54 5. Acinic Cell Carcinoma###03###3.09###1.15 6. Salivary Duct Carcinoma###03###3.09### ...
more infohttps://www.thefreelibrary.com/THE+MORPHOLOGICAL+SPECTRUM+OF+SALIVARY+GLAND+TUMOURS+AT+KEMU+AND+MAYO+...-a0335167804
Salivary gland tumour - Wikipedia  Salivary gland tumour - Wikipedia
... not otherwise specified Basal cell adenocarcinoma Sebaceous carcinoma Sebaceous lymphadenocarcinoma Cystadenocarcinoma Low- ... not otherwise specified Adenocarcinoma, not otherwise specified Myoepithelial carcinoma Carcinoma ex pleomorphic adenoma ... grade cribriform cystadenocarcinoma Mucinous adenocarcinoma Oncocytic carcinoma Salivary duct carcinoma Salivary duct carcinoma ... epithelial tumors Acinic cell carcinoma Mucoepidermoid carcinoma Adenoid cystic carcinoma Polymorphous low-grade adenocarcinoma ...
more infohttps://en.wikipedia.org/wiki/Salivary_gland_tumour
Articles | Veterinarians Montgomery, AL | Goodwin Animal Hospital and Pet Resort  Articles | Veterinarians Montgomery, AL | Goodwin Animal Hospital and Pet Resort
These tumors may be benign 'sebaceous adenomas' or malignant 'sebaceous adenocarcinomas'. Another type of tumor, called a 'mast ...
more infohttp://www.goodwinanimalhospital.com/client-resources/pet-health/articles/?rid=3992
TUMORS OF THE SKIN  TUMORS OF THE SKIN
... sebaceous epithelioma, sebaceous adenoma, and. sebaceous adenocarcinoma. Sebaceous gland tumors are among the most common skin ... Sebaceous hyperplasia is often found peripheral to and phasing into sebaceous adenomas or adenocarcinomas and is likely a ... Ceruminous Gland Adenocarcinoma. Sebaceous hyperplasia/adenoma. Total cases/study. United States. 26.1. 21.6. 15.2. 14.7. 13.0 ... Sebaceous adenocarcinomas are rare in the cat and dog and appear to have a low potential for metastasis and recurrence. They ...
more infohttp://maxshouse.com/tumors_of_the_skin.htm
  • The development of endometrial adenocarcinoma from endometrial hyperplasia is a typical example of how the effects of pathologic hyperplasia can lead to neoplasia, and females who exhibit hyperplasia of the endometrium are indeed more likely to develop cancer of these cells. (wikipedia.org)
  • Within the latter type, the hairs occur in structures called pilosebaceous units, each with hair follicle, sebaceous gland, and associated arrector pili muscle. (wikipedia.org)
  • Miller describes how they work: "Spot treatments work either by spreading over the dogs entire skin surface or by being absorbed through the skin at the point of application, circulating through the blood, and being transported back to the skin over the whole body through the sebaceous gland secretions. (freethesaurus.com)
  • Future studies should clarify whether sebaceous gland IGF-I and survivin expressions are upregulated in sebaceous cell hyperplasia of acne vulgaris and whether isotretinoin treatment downregulates mTORC1, IGF-I, and survivin expression. (freethesaurus.com)
  • Therefore, it would be intriguing to identify the sebaceous gland activity and sebum signatures during childhood in conjunction with sequence-based mycobiome analysis. (freethesaurus.com)