Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Lung Neoplasms: Tumors or cancer of the LUNG.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Barrett Esophagus: A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Adenocarcinoma, Bronchiolo-Alveolar: A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)Stomach Neoplasms: Tumors or cancer of the STOMACH.Cardia: That part of the STOMACH close to the opening from ESOPHAGUS into the stomach (cardiac orifice), the ESOPHAGOGASTRIC JUNCTION. The cardia is so named because of its closeness to the HEART. Cardia is characterized by the lack of acid-forming cells (GASTRIC PARIETAL CELLS).Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Colonic Neoplasms: Tumors or cancer of the COLON.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Esophagogastric Junction: The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Keratin-7: A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Cell Line, Tumor: A cell line derived from cultured tumor cells.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Carcinoma, Signet Ring Cell: A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Cecal Neoplasms: Tumors or cancer of the CECUM.Mammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Adenocarcinoma, Clear Cell: An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)Metaplasia: A condition in which there is a change of one adult cell type to another similar adult cell type.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Rectal Neoplasms: Tumors or cancer of the RECTUM.Ampulla of Vater: A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.Genes, ras: Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.Common Bile Duct Neoplasms: Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.Keratin-20: A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.Tissue Array Analysis: The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.Ileal Neoplasms: Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).Adenoma: A benign epithelial tumor with a glandular organization.Pancreaticoduodenectomy: The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.DNA, Neoplasm: DNA present in neoplastic tissue.Jejunal Neoplasms: Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Carcinoma, Adenosquamous: A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Carcinoma, Acinar Cell: A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Esophagus: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Gastrectomy: Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Paranasal Sinus Neoplasms: Tumors or cancer of the PARANASAL SINUSES.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Carcinoma in Situ: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.Receptor, Epidermal Growth Factor: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Pancreatectomy: Surgical removal of the pancreas. (Dorland, 28th ed)Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Mucins: High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.Gastrointestinal Neoplasms: Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Appendiceal Neoplasms: Tumors or cancer of the APPENDIX.Pancreatic Ducts: Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Gallbladder Neoplasms: Tumors or cancer of the gallbladder.DeoxycytidineSigmoid Neoplasms: Tumors or cancer of the SIGMOID COLON.Esophagectomy: Excision of part (partial) or all (total) of the esophagus. (Dorland, 28th ed)Endometrial Hyperplasia: Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissue. There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Prostatic Intraepithelial Neoplasia: A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.ras Proteins: Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.Carcinoma, Large Cell: A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.CA-19-9 Antigen: Sialylated Lewis blood group carbohydrate antigen found in many adenocarcinomas of the digestive tract, especially pancreatic tumors.Uterine Neoplasms: Tumors or cancer of the UTERUS.Mammary Neoplasms, Animal: Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).Mucin-2: A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Adenoma, Villous: An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Pancreas: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Transplantation, Heterologous: Transplantation between animals of different species.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Carcinoma, Neuroendocrine: A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)Mucin-1: Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.Loss of Heterozygosity: The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.RNA, Neoplasm: RNA present in neoplastic tissue.Cystadenocarcinoma: A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Esophagoscopy: Endoscopic examination, therapy or surgery of the esophagus.Genes, erbB-1: The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.Mesothelioma: A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Biopsy, Needle: Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Anal Sacs: A pair of anal glands or sacs, located on either side of the ANUS, that produce and store a dark, foul-smelling fluid in carnivorous animals such as MEPHITIDAE and DOGS. The expelled fluid is used as a defensive repellent (in skunks) or a material to mark territory (in dogs).QuinazolinesCystadenocarcinoma, Serous: A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Neoplasms, Unknown Primary: Metastases in which the tissue of origin is unknown.Smoking: Inhaling and exhaling the smoke of burning TOBACCO.Ki-67 Antigen: A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.Cyclooxygenase 2: An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Antigens, Tumor-Associated, Carbohydrate: Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.HT29 Cells: Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.Pleural Effusion, Malignant: Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.Mucin-4: A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Hysterectomy: Excision of the uterus.Gene Amplification: A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.beta Catenin: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Urachus: An embryonic structure originating from the ALLANTOIS. It is a canal connecting the fetal URINARY BLADDER and the UMBILICUS. It is normally converted into a fibrous cord postnatally. When the canal fails to be filled and remains open (patent urachus), urine leaks through the umbilicus.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Liver Neoplasms: Tumors or cancer of the LIVER.Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Pancreatitis, Chronic: INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.Neoplasms, Complex and Mixed: Neoplasms composed of more than one type of neoplastic tissue.Cystadenocarcinoma, Mucinous: A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)Nose Neoplasms: Tumors or cancer of the NOSE.Neoplasm Grading: Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Carcinoid Tumor: A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)DNA Methylation: Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Jaagsiekte sheep retrovirus: A BETARETROVIRUS that causes pulmonary adenomatosis in sheep (PULMONARY ADENOMATOSIS, OVINE).Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Digestive System Neoplasms: Tumors or cancer of the DIGESTIVE SYSTEM.Genes, Tumor Suppressor: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Nitrosamines: A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Genes, p53: Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.Carcinosarcoma: A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Smad4 Protein: A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Vaginal Neoplasms: Tumors or cancer of the VAGINA.Neoadjuvant Therapy: Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.Pulmonary Adenomatosis, Ovine: A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Histocytochemistry: Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Rats, Inbred F344Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Duodenogastric Reflux: Retrograde flow of duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the STOMACH.

Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma. (1/35)

AIMS: Regulation of cell cycle progression is a fundamental control process, linked to cellular differentiation and apoptosis in normal tissues. p21(WAF1) is a nuclear protein that regulates cell cycle progression. p21(WAF1) can be transcriptionally upregulated by p53, but may be activated independently of p53-for example, during terminal differentiation. Loss of topological control of p21(WAF1) expression is an early feature of malignancy in the colorectal system. Similar to the colonic mucosa, sebaceous glands contain cells that are constantly going through a process of cell division, differentiation, and cell death. This study investigated the expression of p53, p21(WAF1), and the proliferation marker Ki67 in normal sebaceous glands, sebaceous adenoma, sebaceoma, and sebaceous carcinoma. METHODS: Serial sections were stained with monoclonal antibodies to p21(WAF1), p53, and Ki67 (MIB1) using standard immunohistochemical techniques. RESULTS: In normal sebaceous glands, p21(WAF1) positive cells were only seen within the differentiating compartment, which was spatially distinct from the cycling peripheral Ki67 positive cells. In sebaceous adenoma and sebaceoma, topological control was maintained, with the distribution of markers being similar to that seen in normal sebaceous glands. Loss of topological control of markers of cellular control was seen in sebaceous carcinoma only. This contrasts with colonic tumours, in which loss of p21 compartmentalisation is seen in adenomas at an early stage of tumour progression. CONCLUSION: This work confirms the hypothesis that the dysregulation of cell cycle progression is an important process in the development of malignancy within sebaceous glands, although loss of topological control was seen only in sebaceous carcinoma.  (+info)

Immunohistochemical staining for adipophilin, perilipin and TIP47. (2/35)

BACKGROUND: The presence of lipid in the cell cytoplasm is useful for supporting the diagnosis of sebaceous gland carcinoma (SGC). Currently this requires histochemical stains that are carried out on frozen sections of unprocessed tissue. Recently, several anti-adipocytic antibodies that recognise proteins associated with lipid vesicles have been described. These antibodies can be applied to paraffin-wax sections. AIM: To assess the ability of anti-adipocytic antibodies to identify intracytoplasmic lipid in SGC. METHODS: Immunohistochemistry with a monoclonal antibody to adipophilin and polyclonal antibodies to perilipin and TIP47/PP17 was carried out on archival, formalin-fixed, paraffin-wax-embedded sections of 26 samples of SGC. The immunostaining was compared with 22 other eyelid tumours (11 basal cell carcinomas (BCC), 10 squamous cell carcinomas (SCC) and 1 Merkel cell tumour). RESULTS: Immunohistochemical staining was positive in 23, 10 and 2 cases of 26 SGC with adipophilin, perilipin and TIP47, respectively. The positive staining identified cytoplasmic lipid vesicles. Anti-adipophilin was positive in five other eyelid tumours (4 BCC and 1 SCC) staining small cytoplasmic granules that can be easily distinguished from the staining in SGC. CONCLUSIONS: Immunohistochemical staining for adipophilin and perilipin is a useful ancillary technique for the demonstration of lipid in SGC that may be applied to paraffin-wax sections.  (+info)

Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia. (3/35)

AIM: To determine the complications associated with mitomycin C (MMC) in the treatment of ocular surface neoplasia. METHODS: A retrospective and consecutive study of 100 eyes in 91 patients with ocular surface neoplasia treated with MMC in a single centre between November 1998 and January 2005. Outcome measures included complications of MMC and the treatment required for these complications. RESULTS: One to three 7 day cycles of topical MMC 0.04% four times a day were given to 59 eyes with localised corneal-conjunctival intraepithelial neoplasia (CIN), 19 eyes with diffuse CIN, six eyes with recurrent CIN, one eye with ocular surface squamous cell carcinoma, three eyes with primary acquired melanosis (PAM) with atypia, nine eyes with conjunctival malignant melanoma (MM), two eyes with sebaceous carcinoma with pagetoid spread, and one eye with recurrent atypical fibroxanthoma. Nine patients had bilateral CIN. 31 (34%) cases developed an allergic reaction to MMC and 14 (14%) eyes had epiphora secondary to punctal stenosis at a mean follow up period of 26.5 months. CONCLUSION: In the largest study looking at complications of topical MMC in the treatment of ocular surface neoplasia, allergic reaction and punctal stenosis are relatively common. Serious complications were not observed suggesting the safe use of MMC in mid-term follow up.  (+info)

Activator protein-1 activity regulates epithelial tumor cell identity. (4/35)

To examine the consequences of inhibiting activator protein-1 (AP-1) transcription factors in skin, transgenic mice were generated, which use the tetracycline system to conditionally express A-FOS, a dominant negative that inhibits AP-1 DNA binding. Older mice develop mild alopecia and hyperplasia of sebaceous glands, particularly around the eyes. When A-FOS was expressed during chemical-induced skin carcinogenesis, mice do not develop characteristic benign and malignant squamous lesions but instead develop benign sebaceous adenomas containing a signature mutation in the H-ras proto-oncogene. Inhibiting AP-1 activity after tumor formation caused squamous tumors to transdifferentiate into sebaceous tumors. Furthermore, reactivating AP-1 in sebaceous tumors results in a reciprocal transdifferentiation into squamous tumors. In both cases of transdifferentiation, individual cells express molecular markers for both cell types, indicating individual tumor cells have the capacity to express multiple lineages. Molecular characterization of cultured keratinocytes and tumor material indicates that AP-1 regulates the balance between the wnt/beta-catenin and hedgehog signaling pathways that determine squamous and sebaceous lineages, respectively. Chromatin immunoprecipitation analysis indicates that c-Jun binds several wnt promoters, which are misregulated by A-FOS expression, suggesting that members of the wnt pathway can be a primary targets of AP-1 transcriptional regulation. Thus, AP-1 activity regulates tumor cell lineage and is essential to maintain the squamous tumor cell identity.  (+info)

A clinicopathological study of eyelid malignancies from central India. (5/35)

BACKGROUND: Eyelid malignancies are completely treatable if detected early. The treatment depends on the invasiveness of the cancer which in turn depends on the type of malignancy. AIM: The aim of the study was to characterize the distribution of the types of eyelid malignancies in central India. SETTINGS AND DESIGN: The study was conducted in the Department of Plastic and Maxillofacial Surgery at a tertiary care hospital. MATERIALS AND METHODS: We report a series of 27 cases of eyelid malignancies. In the same case series, we also include a case of malignant hemangiopericytoma which is an extremely rare form of eyelid malignancy worldwide. STATISTICAL ANALYSIS: Depending on the underlying statistical distribution, either analysis of variance (ANOVA) or the Kruskal-Wallis (K-W) test was used to assess the differential distribution of these variables across the types of eyelid malignancies observed in this study. RESULTS: We observed that sebaceous cell carcinoma (approximately 37%) was almost as prevalent as basal cell carcinoma (approximately 44%) in the study subjects and had an earlier age of occurrence and a more rapid clinical course. CONCLUSIONS: Sebaceous cell carcinoma of the eyelid is almost as common as basal cell carcinoma in a large tertiary care centre in central India.  (+info)

Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type. (6/35)

The NH(2) terminus of LEF1 is frequently mutated in human sebaceous tumors. To investigate how this contributes to cancer, we did two-stage chemical carcinogenesis on K14DeltaNLef1 transgenic mice, which express NH(2)-terminally truncated Lef1 in the epidermal basal layer. Transgenic mice developed more tumors, more rapidly than littermate controls, even without exposure to tumor promoter. They developed sebaceous tumors, whereas controls developed squamous cell carcinomas. K14DeltaNLef1 epidermis failed to up-regulate p53 and p21 proteins during tumorigenesis or in response to UV irradiation, and this correlated with impaired p14ARF induction. We propose that LEF1 NH(2)-terminal mutations play a dual role in skin cancer, specifying tumor type by inhibiting Wnt signaling and acting as a tumor promoter by preventing induction of p53.  (+info)

Role of fine needle aspiration cytology in diagnosis of eyelid sebaceous carcinoma. (7/35)

Sebaceous carcinoma of the ocular adnexa is a malignant neoplasm which can exhibit aggressive local behavior and can metastasize to regional lymph nodes and distant organs. The neoplasm is known to masquerade as other benign and less malignant lesions, resulting in delay in diagnosis and relative high morbidity and mortality. Fine needle aspiration cytology (FNAC) of recurrent upper eyelid nodules treated elsewhere as chalazion was done. Cytological smears were suggestive of malignancy. Subsequently histopathology confirmed the diagnosis of sebaceous gland carcinoma. Eyelid reconstruction was done after histopathologically confirmed tumor-free margins. The article highlights the role of FNAC in early diagnosis and subsequent appropriate surgical management of eyelid sebaceous gland carcinoma to prevent recurrence and metastasis.  (+info)

Adnexal skin tumors in Zaria, Nigeria. (8/35)

BACKGROUND: Adnexal skin tumors share many features in common and differentiate along one line. Their detailed morphological classification is difficult because of the variety of tissue elements and patterns seen. They may be clinically confused with other cutaneous tumors. The aim of this report is to review and classify all adnexal tumors seen in a pathology department over a 16-year period. METHOD: A 16-year retrospective analysis of all adnexal skin tumors seen in a large University Teaching Hospital in Nigeria from January 1991- December 2006. All tissue specimens were fixed in 10% formalin, processed in paraffin wax and stained with Haematoxylin and Eosin. Histology slides were retrieved, studied and lesions characterized. RESULTS: Fifty-two adnexal tumors were seen, accounting for 0.9% of all cutaneous tumors seen within the same period. The median age was 33 years (range: 4 days-70 years). Clinical presentations varied from discreet swellings and nodules to ulcerated masses. Five patients presented with recurrent lesions. Only two cases had a clinical diagnosis of adnexal tumor. Twenty-four (46%) of the lesions were distributed in the head and neck region. Duration of symptoms was 2 months to 15 years (median: 12 months). Tumours of the sweat gland were the commonest--41 (78.8%); they comprised predominantly eccrine acrospiroma (17), characterized histologically by solid nests of round to polygonal cells with clear to eosinophilic cytoplasm, forming tubules in areas. Tumours of sebaceous gland were 7 (13.5%); they comprised mainly Nevus sebaceous of Jadassohn (6), composed of immature sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma. Tumours of hair follicle were 4 (7.7%) and included trichoepithelioma, characterized microscopically by multiple horn cysts and epithelial tracts connecting abortive pilar structures and a trichofolliculoma. Forty-six lesions (88.5%) were benign and six (11.5%) malignant. CONCLUSION: Adnexal skin tumors have distinct histological patterns which differentiates them from other cutaneous tumors. They are commonly distributed in the head, neck and trunk. The commonest variants are those of eccrine sweat gland origin. Malignant adnexal tumors are uncommon in our setting.  (+info)

Purpose.: Activation or dysregulation of the Sonic hedgehog (Shh) and Wnt signaling pathways is suggested to lead to the development of many human malignancies. In this study, we investigated Shh and Wnt signaling protein expression in eyelid sebaceous gland carcinoma, and analyzed their correlation with clinical characteristics of the tumor. Methods.: Patients who underwent surgical resection of eyelid sebaceous gland carcinoma from 1999 to 2011 were recruited for the study. Immunohistochemical stainings of Shh signaling proteins (Shh, Gli-1, Gli-2, Gli-3, and ABCG2) and Wnt signaling proteins (Wnt, glycogen synthase kinase 3β, β-catenin, lipoprotein receptor-related protein [LRP], and c-Myc) were conducted. Results.: Thirty-seven cases of eyelid sebaceous gland carcinoma were included in this study. Twenty-nine patients showed no metastasis, and eight patients showed lymph node or distant metastasis. Shh, ABCG2, and Wnt proteins were more highly expressed in the group with metastasis than in ...
Purpose.: To investigate the expression of cancer stem cell (CSC) marker proteins in eyelid sebaceous gland carcinoma and evaluate the clinical significance. Methods.: Archival tissue blocks from 50 cases of eyelid sebaceous gland carcinoma were tested via immunohistochemistry for 16 putative CSC markers. Levels of protein expression were analyzed alongside various clinicopathologic parameters such as metastasis-free survival time. Results.: Ten patients (20%) showed nodal or distant metastasis during the follow-up period (median, 35.2 months; range, 1-128 months) without any mortality in our series. Among the 16 markers, ALDH1, CD44, CD133, ABCG2, Sox4, Sox9, and slug were selected for candidates of CSC markers because they were frequently and predominantly found in the tumor cells compared with control tarsus cells, which showed negative or very low expression. Univariate analysis revealed that ALDH1, CD133, and ABCG2 were significantly associated with metastasis; patients with ALDH1- or ...
Sebaceous carcinoma is an uncommon and aggressive malignant cutaneous tumor.[1] Most are typically about 10 mm in size at presentation.[2] This neoplasm is thought to arise from sebaceous glands in the skin and, therefore, may originate anywhere in the body where these glands are found. Because the periocular region is rich in this type of gland, this region is a common site of origin.[3][4] The cause of these lesions are, in the vast majority of cases, unknown. Occasional cases may be associated with Muir-Torre syndrome.[5][6]. This type of cancer usually has a poor prognosis because of a high rate of metastasis.[2]. ...
Sebaceous carcinoma arises from the glands within the eyelids, caruncle, or eyebrow. They are more common in middle-aged patients.
sebaceous cell carcinoma is found most frequently in the ocular region, which accounts for 75% of cases. The parotid gland is the most common site outside the ocular region, accounting for about 20% of cases.
sebaceous cell carcinoma is found most frequently in the ocular region, which accounts for 75% of cases. The parotid gland is the most common site outside the ocular region, accounting for about 20% of cases.
History: 55 year old woman with enlarging eyelid mass, about 2cm. Biopsy revealed sebaceous carcinoma which must be differentiated from squamous cell carcinoma (and sometimes from basal cell carcinoma) due to different clinical consequences. Sebaceous carcinoma of the periorbital region can be a diagnostic challenge for the clinican and pathologist. Immunohistochemistry may help in this regard ( see reference Sinard JH, Archives of Opthalmology, 117:776-83, 1999). ...
Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. In this context, sebaceous differentiation in MAC would support the first option. However, there are only 3 cases of MAC with sebaceous differentiation in the literature, and all of them were reported before adipophilin was available, which in the appropriate context (eg, testing clear cells for sebaceous vs eccrine differentiation) is very useful ...
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to the editor: Sebaceous cell carcinoma of the eyelid is the fourth most common malignancy in the periocular region in the United States (basal cell carcinoma, squamous cell carcinoma, and melanoma are the leading three causes) and the second most common malignancy in China (basal cell carcinoma is the leading cause).1,2 Diagnosis and therapy tend to be delayed because sebaceous carcinoma is often mistaken for benign entities such as chalazion, conjunctivitis, or blepharitis.3. A 74-year-old woman presented to her ophthalmologist with conjunctival erythema and slight tenderness of her upper eyelid. She was diagnosed with conjunctivitis and prescribed erythromycin 0.5% ophthalmic ointment. At her one-month follow-up visit, she continued to have erythema and had also developed a small tender papule. A diagnosis of chalazion was made, and the patient was instructed to continue her antibiotic ointment and to apply warm compresses four times daily to the eye. At her two-month follow-up visit, the ...
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Most patients diagnosed with SC are treated with surgery. Two types of surgery are used to remove SC:. Excision: During this surgery, the surgeon removes the tumor and some surrounding tissue that looks healthy. This helps to remove cancer that may have traveled to an area that still looks healthy. An area can look healthy if it contains just a few cancer cells.. Mohs surgery: Because many SCs develop on an eyelid or other area with little extra skin, Mohs (pronounced "moes") surgery may be recommended. This specialized surgery is only used to treat skin cancer. This surgery allows the Mohs surgeon to remove less tissue yet remove the entire tumor.. During Mohs surgery, the Mohs surgeon cuts out the tumor plus a very small amount of healthy looking tissue surrounding the tumor. While the patient waits, the Mohs surgeon uses a microscope to look at what was removed. The surgeon is looking for cancer cells. If the Mohs surgeon finds cancer cells at the edge of the removed tissue, the surgeon will ...
ABHD5, PGRMC1 and FDFT1 are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically basal cell carcinoma (BCC) with clear cell features ...
Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be primary (starts within the eye) or metastatic cancer (spread to the eye from another organ). The two most common cancers that spread to the eye from another organ are breast cancer and lung cancer. Other less common sites of origin include the prostate, kidney, thyroid, skin, colon and blood or bone marrow. Tumors in the eye and orbit can be benign like dermoid cysts, or malignant like rhabdomyosarcoma and retinoblastoma. The most common eyelid tumor is called basal cell carcinoma. This tumor can grow around the eye but rarely spreads to other parts of the body. Other types of common eyelid cancers include squamous carcinoma, sebaceous carcinoma and malignant melanoma. The most common orbital malignancy is orbital lymphoma. This tumor can be diagnosed by biopsy with histopathologic and immunohistochemical analysis. Most patients with orbital lymphoma can be offered ...
Papillomas or warts are easily recognized skin or mucous membrane tumors. They are common in wild species and are particularly well known in deer (Cosgrove and Fay 1981; Sundberg and Nielson 1981). Most of these tumors are caused by papillomaviruses (PVs). Tumors can become quite large and numerous and persist for prolonged periods, but they usually regress, providing the individual with long-term immunity to future infections. Occasionally, the tumors will progress to squamous cell carcinoma, adenosquamous carcinoma, or sebaceous carcinoma that will eventually kill the host if not treated. Specific mucosotropic PV types and those infecting immunodeficient individuals are prone to induce malignancies. Virtually all mammalian species are hosts for one of more PV. This chapter provides an overview of PV infections in mammals ...
Eyelid tumours are fortunately uncommon, and most are not cancers that can spread elsewhere in the body. However, if they are not treated, they will grow and ultimately cause damage to the eyelid and surrounding tissues. Surgery is the treatment of choice for all eyelid tumours and they should be removed promptly to ensure the best outcome. Surgical excision is almost always curative and the lesion can usually be removed without significant cosmetic impact, especially if done at an early stage. Although the diagnosis may be obvious at your consultation, in some cases a preliminary biopsy will be necessary to confirm the precise type of tumour prior to definitive treatment. This biopsy is performed under local anaesthetic and a small piece of the tumour is removed to be examined under a microscope.. ...
Malignant tumours affecting the eyelid include basal cell carcinoma (85% to 95%), squamous cell carcinoma (approximately 5%), sebaceous carcinoma (1% to 5%), and malignant melanoma (1%). Non-Hodgkins lymphoma of the eyelid is rare. This report is of an 80-year-old woman who presented with diffuse left upper eyelid swelling, clinically suspected to be a haemangioma. Rare diseases should be considered in differential diagnoses because they have the potential for rapid systemic involvement and may need treatment that is different from that of other common diseases at the same site.. ...
Breast cancer is common in women and its metastases involve the skin in approximately one quarter of patients. Accordingly, metastatic breast cancer shown to be cutaneous through histology must be distinguished from a wide variety of other neoplasms as well as the diverse morphologic variants of breast cancer itself. We report the case of a 61-year-old Caucasian woman with cutaneous metastases of a bilateral ductal breast carcinoma that in histopathological examination mimicked an adnexal neoplasm with sebaceous differentiation. Against the background of metastatic breast carcinoma, dermatopathological considerations of sebaceous differentiation of skin lesions are presented and discussed focusing on the rare differential diagnosis of sebaceous carcinoma of the breast.
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TY - JOUR. T1 - Clinical, dermoscopic and reflectance confocal microscopy features of sebaceous neoplasms in Muir-Torre syndrome. AU - Moscarella, E.. AU - Argenziano, G.. AU - Longo, C.. AU - Cota, C.. AU - Ardigò, M.. AU - Stigliano, V.. AU - Mete, L. S.. AU - Donati, P.. AU - Piana, S.. AU - Silipo, V.. AU - Catricalà, C.. AU - Albertini, G.. AU - Zalaudek, I.. PY - 2013/6. Y1 - 2013/6. N2 - Background Muir-Torre syndrome (MTS) is an autosomal-dominant disorder characterized by the association of sebaceous tumors or keratoacanthomas with an early onset visceral cancer in the spectrum of Lynch syndrome. Observations A total of 20 sebaceous tumors including 18 sebaceous adenoma and two sebaceomas of six patients with MTS were analysed. Two main clinico-dermoscopic features were observed: (1) clinically pink to white papules/nodules with a central crater, dermoscopically characterized by radially arranged, elongated crown vessels surrounding opaque structureless yellow areas at times covered ...
DNA was extracted from 86 lesions including 17 proliferating tricholemmal and trichilemmal tumors, 15 trichoblastomas, 7 trichoadenomas, 4 pilomatricomas, 1 pilomatrical carcinoma, 4 basal cell carcinomas (BCCs) with shadow cells, 2 trichofolliculomas, 3 BCCs with sebaceous differentiation, 9 sebaceous adenomas, 6 sebaceomas, 14 sebaceous carcinomas (both ocular and extraocular forms), 2 gigantic horns, and 2 apocrine mixed tumors with shadow cells and subjected to polymerase chain reaction with newly designed primers encompassing glycogen synthase kinase-3beta phosphorylation sites of the CTNNB1 gene ...
Results There were a total of 160 male patients (48%) and 173 female patients (52%). The median age at diagnosis was 66 years (range 31-95) for male subjects and 67 years (35-99) for female subjects. The average annual age-standardised incidence rate of all eyelid cancers over the 13 years was 5.0 per million. A significant decrease in rates from 6.6 per million in the 1996-1998 period to 3.9 per million in the 2005-2008 period with an annual percentage change of 3.6% (95% CI −6.5 to 0.7%; p=0.02) was noted for women. The most common cancer was basal cell carcinoma (82%), followed by sebaceous gland carcinoma (11%) and squamous cell carcinoma (4%).. ...
Benign and cancerous tumors of the eyelid are common. In sunny climates, the lower eyelids are a common location for skin cancers. New lesions of the eyelids and eyelid margins should be carefully assessed and frequently need to be biopsied. In general, early detection yields excellent results with removal and reconstruction. In advanced cases, more complex reconstruction may require grafting or rotation flaps to fully repair the area removed with the tumor.. ...
Find Best Puffy Eyelids Treatment in Ulhasnagar 3, Thane. 365Doctor.in are providing Top 10 Puffy Eyelids Treatment in Ulhasnagar 3, Thane. Doctor reviews its helpful for you.
Swollen eyelid toddler - My child is 11 months old and his left eyelid is very swollen and little red today. It started looking puffy yesterday and now it is much worse..? See yourMD first. I would recommend seeing your pediatrician first.
Comprehensive guide that has all the information you need to know about Uneven eyelids. This article covers all the ways that you can fix this problem!
a personal list of elements that help me remember that any day will have some redeeming quality- often including something outdoors
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Hi Andrew, I have a 10 year old Yorkie/Maltese (her tummy skin is light coloured, but she has black hair). I noticed a growth on top of her head (about a fingers width away from her right eye) that started growing about a year ago and it has increased in size gradually (no fast growth within a month or anything like that). For your reference, it is now the size of two green peas. I recently gave her a haircut and started worrying more… At first I thought it was a skin tag, but the growth is black in colour. After reading your post, it looks very similar like the sebaceous adenoma (same size and bumpy look, except it is black in colour). It also seems to be attached to the head on one side only (you can move and lift the other side up). Recently, I started putting vitamin E oil on it (for 3 days only) because initially I thought it was a wart (I know it isnt a wart now), but the vitamin e oil seems to have irritated it because when she rubs her head on the floor or when I wipe it with tissue, ...
The sebaceous glands are minute glands of the skin. It is distributed in the entire skin of the human body except for the palms of the hands and soles of the feet. Location, Pictures, Function...
How To Make Your Eyelids Bigger Naturally at Home, how to get bigger eyelids naturally how to make eyelids look bigger with makeup how to get double eyelids naturally without tape
Are you looking for the best eyelid surgery clinics near Altonah in Utah? This page has all the information about Eyelid surgery clinics in Altonah, UT you need. Find Eyelid surgery clinic perfect for you NOW!
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... Lots of people are getting eyelid surgery to look younger. Try it in Charlotte NC.
Eyelid Surgery prices from £1269 - Enquire for a fast quote. Free consultation. Choose from 40 Eyelid Surgery Clinics in Harley Street with 14 verified patient reviews ★ find the best one for you.
A swollen eyelid can be caused by inflammation in the tissues around the eye. Learn more about puffy eyelids including symptoms, causes, and treatment.
Beautiful Asian eyelid surgery for men & women with the help of Joel Kopelman MD oculoplastic eyelid specialist with 30+ years of experience
Check out some of the coolest and quirkiest eyelid world records and videos. Impress your friends by breaking or inventing your own eyelid world records on Recordsetter.com.
Read 6 responses to: My son woke up with a swollen eyelid, it obviously... Find the best answer on Mamapedia - mom trusted since 2006.
We have a 17 week old fox red lab, and just this weekend picked up an 11 week old black lab. All is good, until this morning I looked at the black lab
To clarify the features of apocrine mixed tumors (AMT) of the skin among benign neoplasms with apocrine differentiation in their relationship to follicular stem cells, we investigated the immunohistochemical expression of CK15 (LHK15 and C8/144B), which is a relatively specific marker of hair follicle stem cells in the bulge, in 35 cases of eight different benign neoplasms with presumed apocrine differentiation ...
Kidney tumors can be divided into many types, different types of very different clinical manifestations and prognosis. The most common classification is that it can be divided into benign and malignant renal tumors in two categories. The most common benign tumors including renal cyst single kidney sebaceous tumors ect. Common kidney cancer in adults with renal cell carcinoma, pelvic cancer ect. The most common in infants and young children are Wilms tumor ...
Eyelid defects disrupt the complex natural form and function of the eyelids and present a surgical challenge. Detailed knowledge of eyelid anatomy is essential in evaluating a defect and composing a reconstructive plan. Numerous reconstructive techniques have been described, including primary closure, grafting, and a variety of local flaps. This article describes an updated reconstructive ladder for eyelid defects that can be used in various permutations to solve most eyelid defects ...
Droopy eyelids or eyelid ptosis can be caused by a number of things and treated by a droopy eyelid surgery. Find out what causes droopy eyelids.
Eyelid Surgery Lebanon is a method to remove fat and excess skin from the eyes. Eyelid Surgery reduces or removes the imminent eyelids, which often gives a tired appearance, although it is the opposite.
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Dr. Zoumalan in Beverly Hills, has extensive training in Asian eyelid surgery (Double eyelid surgery). Call for a personal consultation with Dr. Zoumalan.
OcuSight offers eyelid surgery for droopy eyelids, a surgical correction of the eye brow and eyelids for visual, comfort or cosmetics reasons throughout the greater Rochester, NY region.
Eyelid Surgery prices from ₱30305 - Enquire for a fast quote. Free consultation. Choose from 16 Eyelid Surgery Clinics in Makati City with 45 verified patient reviews ★ find the best one for you.
Conditions that cause lesions of the eyelid include benign and malignant diagnoses. Patients with eyelid abnormalities commonly present to their primary care physician. Primary care clinicians, therefore, must be able to identify serious conditions t
Eyelid TapeItchy Eyelid28.07.2011 · Best Answer: Thats just a Stye. Its nothing to worry about. Ive had many in my life!!! They are... Blog.cz - Stačí otevřít a budeš v obraze.
Are you interested on a double eyelid surgery? To ensure successful results its important to know if you can pass as a good candidate for the procedure.
Among all the diseases of the eye, eyelids pathologies occupy approximately 10%, while, in most cases, these diseases are inflammatory in nature. Typically,
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Epidermal-derived: Clear cell acanthoma ; Bowens disease ; Basal cell carcinoma. Adnexal tumours: Pagets disease; Clear cell syringoma ; Clear cell hidradenoma ; Clear cell hidradenocarcinoma ; Clear cell porocarcinoma ; clear cell myoepithelioma;. Tricholemmoma ; Tricholemmal carcinoma ; Sebaceous adenoma ; Sebaceous carcinoma.. Nevomelanocytic: Balloon cell nevus ; Balloon cell melanoma ; Clear cell melanoma ; Clear cell sarcoma.. Mesenchymal: Clear cell dermatofibroma; Clear cell atypical fibroxanthoma ; Clear cell fibrous papule.. Salivary gland: Acinic cell carcinoma; Hyalinizing clear cell carcinoma ; Clear cell mucoepidermoid carcinoma.. Metastases: Renal cell carcinoma ; Breast carcinoma ; Hepatocellular carcinoma ; Pulmonary adenocarcinoma and mesothelioma.. Clear cell carcinoma of Skin: 1. Clear cell (hydropic) basal cell carcinoma and squamous cell carcinoma 2. Clear cell variant of Atypical fibroxanthoma. 3. Clear cell porocarcinoma 4 Hidradenocarcinoma. 5. Sebaceous carcinoma 6. ...
About Max: Were back. He does this half "woof" have "whoot" sound all the way there. I have to keep rubbing his head. He is the only dog that is excited to be there. Then the girl comes out and loves on him and he eats that up. He goes in the back and gets his chemo pill in a wad of food, several treats and more loving. In general, I think he likes it. They call him a "character" and laugh, so he must entertain them. I can always hear him coming back. He had a couple of hard nodules come up on the side of his face but these are not the lymphoma, but sebaceous adenomas. So he eats like a horse and runs and plays and has the "drama guilt trip" ploy to sleep in the sunroom, down pat. All in all he still has a good life. My main concern now is that he cant have any vaccine with live virus. He can have the rabies but nothing else. The other vet requires Bordetella vaccine for grooming. So I will have to talk to them. He can no longer get the distemper booster either ...
We dont currently feature information about ptosis or eyelid surgery on Better Vision Guide, so I thought Id spend a bit of time in this post discussing it.. Its true that the vast majority of eyelid surgeries, called blepharoplasty or eye lift, are performed for cosmetic purposes. However, correction of a sagging or drooping eyelid can be more problematic than simply making you look a few years older. If the upper eyelid droops far enough, it can cover the pupil, impeding your ability to see (ptosis).. Ptosis can develop as a natural part of the aging process, but it can also be present at birth. Congenital ptosis poses additional risks because it can impair the visual development of children. For instance, lazy eye (amblyopia) is a common condition that children with ptosis are at risk of developing. Congenital ptosis may also be the sign of a larger issue such as muscular disease, eye-movement issues, neurological disorders or eyelid tumors. For this reason, its imperative that you have ...
This program explains eyelid surgery. Eyelid surgery is also known as blepharoplasty or eyelid lift. The program includes the following sections: what causes changes in the skin and the eyelids, what is facial cosmetic surgery, what is eyelid surgery, what are alternative treatments to eyelid surgery, how is eyelid surgery performed, what are risks of eyelid surgery, and what to do after eyelid surgery.
Drooping eyelids are called ptotic eyelids. Eyelid ptosis in adults is usually a result of ageing that affect the muscles in the eyelid that are designed to lift the upper eyelid.
Common eyelid problems include excess eyelid skin, droopy eyelids or eyelids that turn inward or outward. The problems can cause eye discomfort, limit vision, and affect appearance. These problems are usually nothing to worry about, they can be corrected with surgery.
The eyelid reconstruction surgeons at Ophthalmic Associates of the Southern Tier are experience in reconstructing the eyelids after trauma or cancer treatment
There are all kinds of great eyeshadow looks, but theres one that really works to give me an instant eyelid lift! Once hooded eyelids age, the skin can become saggy and crepey making it really difficult to apply eyeshadow, so this look takes some practice and good tools to get right. I couldnt do eyeshadow like this 18 months ago, but with a lot of practice and some new brushes, Ive upgraded my skills to the point that people ask me if Ive had an eyelid lift when I wear this look!. Heres the finished look:. ...
... - Eye Lift Eyelid surgery is a great way to quickly restore the youthful appearance to the eyes, adding a fresh new look to your overall ...
List of 7 causes of Eyelid Myokymia (Twitching eyelid), patient stories, 2 drug side effect causes, diagnosis questions, and associated symptoms.
cleverbot - sleepy trance - You are getting very sleepy.... - I am getting very sleepy... - Your eyelids are getting heavy... - My eyelids are getting heavy... - You cannot keep your eyes open. - a report from the cleverness files - Cleverbot chat - AI
The plethora of lesions that can occur on the eyelids is rather daunting, not to say confusing, to the average clinician. Many names are similar and while they
just the other day i picked up a product called koji eye talk. basically eyelid glue for asians! yay~~i actually just got it for the sake of having it in my make up collection. but little did i know i woke up with very awkward eyes today ...
Hi everyone I ve read most of the PS threads and realise that there are negative and postive comments for surgeons like dr nara and dr kim. I would really need a recommendation for a doctor that is best at double eyelid surgery... i would really appr..
Hi everyone,do you believe that the maquila Tal Peleg makes art in his eyelid. She decided use their ability with shaping and shadow to create scenes in movies or in stunning images. ...
Eyelid inflammation can be caused by many different things, including allergies, reactions to environmental conditions, bacteria...
I have had many questions on how to avoid getting mascara on your eyelids upon application, and sorry I am barely getting around to it now! I actually bought this mascara guard back in January I believe from a little Asian store near the BFs house (for any of you that live in Southern California, its in the Diamond Life Plaza), for around $3. I went back recently and they didnt have anymore so I am not sure if they are just out of stock. But you can also find it here on this website for around $6 Onatoko.com, and the one shown is the EXACT one I bought ...
Although a stye can look frightening and you may be worried about it because it develops on the eyelid, it is a common issue and many of us had it once in a lifetime.
The subtype of Muir-Torre syndrome, allelic to hereditary nonpolyposis colorectal cancer is typically associated with germline mutations in the mismatch repair proteins MSH-2 and/or MLH-1. More recently, mutation in an additional mismatch repair protein MSH-6 has been documented in a patient with Muir-Torre syndrome. Given this, the aim of the present study was to ascertain the frequency of the same in unselected sebaceous gland neoplasms. Overall, we found that 59% of sebaceous neoplasms exhibited a mutation in at least one mismatch repair protein gene -- a prevalence rate similar to that reported previously by others. Of interest, we found MSH-6 to be the mismatch repair protein most commonly lost 17/41 (41%), followed by MSH-2 14/41 (34%) and MLH-18/41 (20%) and the positive predictive value of each were as follows: MLH-1 88%, MSH-6 67% and MSH-2 55%. The frequency of a MSH-6 germline mutation in our cohort indicates that it is not a rare finding. Evidence indicating microsatellite stability in three
Sebaceous gland on penis - My sebaceous glands are over active. Almost done fighting cold/flu. Could it be immune system reaction, hormones or simply change in weather. Male 42? ComplexManyBehaviors. Blamed on outer influences &/or internal controls without much understanding; the reason that so many promoted treatments do not work (or not well) despite complexity & expense. The medical disease industry (including those with MDs) only partially understand Soul↔Mind↔Brain↔Body creatures. Primary control of sebaceous glands is autonomic. Many do better with LCHF foods, study DietDoctor. Com
Eyelid defects disrupt the complex natural form and function of the eyelids and present a surgical challenge. Detailed knowledge of eyelid anatomy is essential in evaluating a defect and composing a reconstructive plan. Numerous reconstructive techniques have been described, including primary closure, grafting, and a variety of local flaps. This article describes an updated reconstructive ladder for eyelid defects that can be used in various permutations to solve most eyelid defects ...
A droopy eyelid correction elevates the upper eyelid to a desirable position with a natural shape. Let Allure Medical correct your droopy eyelids today.
Eyelid surgery is a very popular procedure around Australia. Check for some more Eyelid Surgery before and after photos here and call us now!
Dr lanzer was one of the pioneer cosmetic surgeons offering cosmetic laser for eyelid surgery. Visit his clinics and get a free Eyelid consultation.
Get great results to repair your eyelid lacerations with the help of Joel Kopelman MD a top eyelid surgeon with 30+ years of experience
Is Eyelid Oedema a common side effect of Olay? View Eyelid Oedema Olay side effect risks. Female, 61 years of age, weighting 200.0 lb, was diagnosed with sunburn, prophylaxis and took Olay Apply Liberally 15 Mins B4 Sun, Applied To A Surface, Usually The Skin.
Tracklist: Trachimbrod 1. I am Jacks Wasted Life 2. Erect, Eyes Closed Sore Eyelids 3. Next To Nothing 4. Dissolve Great split between two bands from Stockholm, Sweden, the screamo/emo band Trachimbrod and a the shoegazer/emo band Sore Eyelids featuring members of Suis La Lune, Mixtapes and Cellmates, New Decade, Years Passing. Higly recommended! Download Support: Buy
China IP65 20W 4000k Hi Efficiency Al Diecast Eyelid LED Wall Light, Find details about China LED Wall Light, LED Bulkhead Light from IP65 20W 4000k Hi Efficiency Al Diecast Eyelid LED Wall Light - SHENZHEN CGI TECHNOLOGY CO., LTD.
China IP65 20W 3000k Hi Efficiency Al Diecast Eyelid LED Wall Light, Find details about China LED Wall Light, LED Bulkhead Light from IP65 20W 3000k Hi Efficiency Al Diecast Eyelid LED Wall Light - SHENZHEN CGI TECHNOLOGY CO., LTD.
Treatment for External Eyelid Stye in Old Capitol Site, Quezon City. Find Doctor & Book an appointment online, View Reviews, Fees & Cost for treating External Eyelid Stye in Quezon City
Reported to have sold 7,000 units in its first month of sales alone, the Eyelid Trainer is designed to be worn for five minutes per day. You wear it like a pair of glasses, so you may look a little silly but it is ideal for busy women who want to work on their appearance while, for example, in the bath or doing another task. As you blink, you will be "training" your eyelids to get bigger.. ...
Double Eyelid Tape 100pcs. Effective even on stubborn single eyelid. Its pre cut and ready to apply. Hassle free, no mess, pre... RP168,900 RP144,000 ...
Dr Patrick Briggs offers eyelid surgery. Visit our Perth-based consultation rooms where Dr Briggs will assess you and present options. Contact us today.
Dr Patrick Briggs offers eyelid surgery. Visit our Perth-based consultation rooms where Dr Briggs will assess you and present options. Contact us today.
At my daughters last doctors visit a doctor, which isnt her usual doctor, said she has a drooping eyelid/ lazy eye. The doctor said she night have to wear a patch or even surgery. I am really freaking out about this. i have pictures on my profile if anyone want to look and tell me what they think. I have never seen a baby with either condition and would like to know what others think. Sometimes you can notice a big difference and sometimes you cant.
Getting an early start: Do your eyelids droop as the White Sox games drag? Does the sandman hit before the ninth inning? Does it make you mad to go to sleep without the final score? Well, the Sox
Dr Mike Wyndham was asked to look at this lesion almost as an afterthought by the childs mother. He recalls how he made the diagnosis
Do you want to learn more about the benefits of the smart use of Pellevé®? Dr. Debra Kroll is a Real Self Top Doctor with 5 star rating reviews. Learn more.
The appearance of hooded eyelids can be specifically addressed by upper eyelid surgery. This type of procedure is best suited for individuals with significant amounts of loose, sagging skin in the upper eyelids.. Generally, a tiny incision following the natural contour of the upper eyelid and possibly extending to the outer edges will be made. The incision makes it possible for Dr. Elliott to remove or redrape excess skin. Fat may be repositioned or removed while underlying muscles may also be tightened. A standard upper eyelid surgery takes less than one hour to perform.. The majority of patients who undergo an upper eyelid surgery may also need a forehead/brow lift. This has to do with the proximity of the brows and the upper eyelids. A thorough physical assessment and a discussion of your cosmetic goals with Dr. Lavey will help figure out whether or not you need a brow lift with your blepharoplasty.. Healing following eyelid surgery varies from one patient to another. Some may have normal ...
Sometimes annoying itches to the eyelid may last longer than expected, and be a first alarm bell for more important issues. There is talk of dermatitis of the eyelids, which is a set of dermatological diseases borne by the eyelid. Lets find out what they are and what causes. Dermatitis of eyelids With the term dermatitis of eyelids indicate dermatological diseases localized mainly in the eyelid, but also in the neighboring areas. To understand the kind of disease is essential to consult an ophthalmologist, who will best indicate any therapy performed and what drugs to use for care. Image Source: Google Image But because the rash affects the eyelids? Its actually a lot simpler. The eyelids are covered with a thin skin that, like the rest of the body, may be subject to the same inflammations, infections or rashes. Among the most important diseases of the eyelids is certainly the Blepharitis, an inflammation of the eyelid charged, specifically the edge of the eyelid. The disease is characterized by the
A sebaceous gland is a small gland in the skin which secretes sebum, a fatty substance that acts as a protective and water repellant layer on skin and allows the epidermis to retain its suppleness; sebum also contains some antibacterial substances. Sebum secretion is fairly constant but varies from individual to individual. Obstructed sebaceous glands become blackheads which are the basis for acne ...
What is basal cell carcinoma?. Basal cell carcinoma is the most common form of skin cancer. This cancer occurs most frequently in light skinned individuals in their fifties and sixties. It is more common in people that have a history of sun exposure. Basal cell carcinoma does not spread through the blood stream or lymph system, but it can grow. It is therefore recommended that the tumor be removed.. Is surgery for eyelid tumors difficult?. Of course, the type of surgery one undertakes is dependent on the type and size of the growth. In general the surgery is performed as an outpatient under a local anesthetic with light sedation. The tumor is removed, the margins checked by a pathologist and the eyelid reconstructed using numerous excellent techniques.. ...
... sebaceous cysts, and osteomata (benign bone tumors). The combination of polyposis, osteomas, fibromas and sebaceous cysts is ... particularly ampullary adenocarcinoma). Other signs that may point to FAP are pigmented lesions of the retina ("CHRPE- ...
... adenocarcinoma, sebaceous MeSH C04.557.470.550.175 --- adenoma, sweat gland MeSH C04.557.470.550.175.125 --- acrospiroma, ... adenocarcinoma, sebaceous MeSH C04.557.470.200.025.152 --- adrenocortical carcinoma MeSH C04.557.470.200.025.200 --- carcinoid ... adenocarcinoma, bronchiolo-alveolar MeSH C04.557.470.200.025.045 --- adenocarcinoma, clear cell MeSH C04.557.470.200.025.060 ... adenocarcinoma, mucinous MeSH C04.557.470.200.025.085 --- adenocarcinoma, papillary MeSH C04.557.470.200.025.085.225 --- ...
... not otherwise specified Basal cell adenocarcinoma Sebaceous carcinoma Sebaceous lymphadenocarcinoma Cystadenocarcinoma Low- ... not otherwise specified Adenocarcinoma, not otherwise specified Myoepithelial carcinoma Carcinoma ex pleomorphic adenoma ... grade cribriform cystadenocarcinoma Mucinous adenocarcinoma Oncocytic carcinoma Salivary duct carcinoma Salivary duct carcinoma ... epithelial tumors Acinic cell carcinoma Mucoepidermoid carcinoma Adenoid cystic carcinoma Polymorphous low-grade adenocarcinoma ...
Low-grade serous adenocarcinomas resemble Fallopian tube epithelium, whereas high-grade serous adenocarcinomas show anaplasia ... sebaceous tumor, and struma ovarii can also be part of the dermoid cyst. They are treated with surgery and adjuvant platinum ... Mucinous tumors include mucinous adenocarcinoma and mucinous cystadenocarcinoma. Mucinous adenocarcinomas make up 5-10% of ... Clear-cell adenocarcinomas are histopathologically similar to other clear cell carcinomas, with clear cells and hobnail cells. ...
It also was expressed at high levels in differentiating cells such as hair follicles, epidermis and sebaceous glands. Wei et al ... miR-203 has been found overexpressed in pancreatic adenocarcinoma and shows correlation with poor prognosis in patients that ... "MicroRNA-203 Expression as a New Prognostic Marker of Pancreatic Adenocarcinoma". Ann Surg Oncol. 17 (12): 3120-8. doi:10.1245/ ...
Sebaceous hyperplasia - In this condition, small yellowish growths develop on the skin, usually on the face. This condition is ... The development of endometrial adenocarcinoma from endometrial hyperplasia is a typical example of how the effects of ... Atypical endometrial hyperplasia may represent an early neoplastic process which can lead to endometrial adenocarcinoma. ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
M8410/0 Sebaceous adnoma (C44._) M8410/3 Sebaceous adenocarcinoma (C44._) Sebaceous carcinoma M8413/3 Eccrine adenocarcinoma ( ... Basophil adenocarcinoma Mucoid cell adenocarcinoma M8310/0 Clear cell adenoma M8310/3 Clear cell adenocarcinoma, NOS Clear cell ... M8140/2 Adenocarcinoma in situ, NOS (M8140/3) Adenocarcinoma, NOS M8140/6 Adenocarcinoma, metastatic, NOS M8141/3 Scirrhous ... Parietal cell adenocarcinoma M8215/3 Adenocarcinoma of anal glands (C21.1) Adenocarcinoma of anal ducts M8220/0 Adenomatous ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
A sebaceous adenoma is a cutaneous condition characterized by a slow-growing tumour usually presenting as a pink, flesh- ... Adenocarcinoma Table 6-5 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology ... at which point they are called adenocarcinomas. Most adenomas do not transform. But even while benign, they have the potential ...
medulloblastoma] ,1%; Liver hepatoblastoma 1.6%; Bile ducts adenocarcinoma Low but increased; Stomach adenocarcinoma ,1% in ... sebaceous cysts, and osteomata (benign bone tumors). The combination of polyposis, osteomas, fibromas and sebaceous cysts is ... "Small bowel [duodenum or periampulla] carcinoma 4-12% [distal to duodenum] Rare; Pancreas Adenocarcinoma ~1%; Papillary thyroid ... particularly ampullary adenocarcinoma). Other signs that may point to FAP are pigmented lesions of the retina ("CHRPE- ...
Anal sac adenocarcinoma Hyena butter Rosell, F.; Jojola, S. M.; Ingdal, K.; Lassen, B. A.; Swenson, J. E.; Arnemo, J. M.; ... Sebaceous glands within the lining secrete a liquid that is used for identification of members within a species. These sacs are ... This is usually done in the case of recurrent infection or because of the presence of an anal sac adenocarcinoma, a malignant ...
Esophageal cancer may be due to either squamous cell carcinoma (ESCC) or adenocarcinoma (EAC). SCCs tend to occur closer to the ... It originates in the pilo-sebaceous glands, and is similar in clinical presentation and microscopic analysis to squamous cell ... mouth, while adenocarcinomas occur closer to the stomach. Dysphagia (difficulty swallowing, solids worse than liquids) and ...
en:Sebaceous carcinoma (4). *en:Seborrheic keratosis (13). *en:Shark attack (18) → 상어 공격 ... en:Adenocarcinoma of the lung (6). *en:Adenoidectomy (15). *en:Adhesion (medicine) (9) ...
Sebaceous. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full ... Rapidly invading sebaceous carcinoma of the external auditory canal. A very rare case of a sebaceous carcinoma of the external ... Sebaceous carcinoma arising on actinic keratosis. We report two cases of sebaceous carcinoma arising on actinic keratosis. The ... A case of multiple sebaceous epithelioma: analysis of microsatellite instability. Sebaceous gland tumor is a rare disease that ...
Stomach Adenocarcinoma. Stomach Polyp. Stomach Ulcers. Sebaceous Cyst. Tubulovillous Adenoma Colon or Rectum. ...
Adenocarcinoma, Renal.. Adenocarcinoma, Salivary Gland.. Adenocarcinoma, Skin (Sweat Gland, Sebaceous).. Adenocarcinoma, ... Adenocarcinoma, Anal Sac/Perianal.. Adenocarcinoma, Lung.. Adenocarcinoma, Nasal.. Adenocarcinoma, Pancreas.. Adenocarcinoma, ... Adenocarcinoma, Thyroid-Dogs.. Aggression, Fear-Cats.. Aggression, Fear/Defensive-Dogs.. Aggression, Food, Possessive and ... Ceruminous Gland Adenocarcinoma, Ear.. Chagas Disease (American Trypanosomiasis).. Chediak-Higashi Syndrome.. Chemodectoma. ...
sebaceous gland adeno-carcinoma 121 What characterises a malignant melanoma? (5) irregular borders. fast growing colour changes ...
Sebaceous adenomas and adenocarcinomas. *Squamous cell carcinoma (white cats). *Mast cell. Other ...
Sebaceous Adenocarcinoma Tue May 15, 2018 8:59 pm. Frantic. 0. left submandibular gland adenocarcinoma Sun Dec 09, 2018 12:54 ... Adenocarcinoma salivary gland Mon Apr 27, 2015 10:54 pm. Clare. 0. Adenoid Cystic Carcinoma of the Salivary Gland Sun Jun 07, ...
Sebaceous Carcinoma Fri Jan 12, 2018 1:32 pm. Lilichka1. 0. Adenocarcinoma metastatic origin breast/ apocrine neoplasm Thu Sep ... Aggresive digital papillary adenocarcinoma Fri Aug 11, 2017 1:12 pm. SallyL. 0. Merkel Cell Carcinoma Mon Jun 19, 2017 6:33 am ... Adenoid Cystic Carcinoma sebaceous gland, right arm Sat Nov 17, 2012 11:27 pm. ... Skin and Sweat & Sebaceous Gland Cancers. digital papillary, eccrine, apocrine, mucinous eccrine, microcystic adenexal ...
Digital Papillary Adenocarcinoma Wed Apr 27, 2011 12:33 pm. natsisn. 0. Sebaceous Adenocarcinoma Tue May 15, 2018 8:59 pm. ... Aggresive digital papillary adenocarcinoma Fri Aug 11, 2017 1:12 pm. clickerchic. 1. hidradenocarcinoma Sun Mar 11, 2018 9:05 ... Aggressive Digital Papillary Adenocarcinoma Thu Feb 09, 2012 2:02 pm. bedrock. 0. microcystic adnexal carcinoma Wed Mar 04, ... Adenocarcinoma metastatic origin breast/ apocrine neoplasm Thu Sep 14, 2017 9:59 am. ...
Sebaceous Adenocarcinoma Tue May 15, 2018 8:59 pm. Andrey. 0. Sweat Gland Tue Jun 26, 2018 6:21 am. ... Aggresive digital papillary adenocarcinoma Fri Aug 11, 2017 1:12 pm. Lilichka1. 0. Adenocarcinoma metastatic origin breast/ ... Skin and Sweat & Sebaceous Gland Cancers. digital papillary, eccrine, apocrine, mucinous eccrine, microcystic adenexal ... Cancer of sweat gland - Malignant adenocarcinoma - eccrine Sun Nov 09, 2014 9:55 am. ...
Sebaceous Wed May 17, 2017 9:43 pm. natsisn. 0. Sebaceous Adenocarcinoma Tue May 15, 2018 8:59 pm. ... Digital Papillary Adenocarcinoma Thu Oct 11, 2012 1:02 pm. mushroomlady. 1. Digital Papillary Adenocarcinoma Wed Apr 27, 2011 ... Aggressive Digital Papillary Adenocarcinoma Thu Feb 09, 2012 2:02 pm. wwitz. 1. Aggressive Digital papillary adenocarcinoma Sun ... Aggresive digital papillary adenocarcinoma Fri Aug 11, 2017 1:12 pm. Roth. 0. Aggressive Digital Papillary Adenocarcinoma ...
Duodenal adenocarcinoma. 0006771 Sebaceous gland carcinoma. 0030410 Showing of 19 , View All. ... in affected people include sebaceous epitheliomas, sebaceous carcinomas (which commonly occur on the eyelids) and ... Sebaceous adenoma is the most characteristic finding in people with Muir-Torre syndrome. (MTS). Other types of skin tumors. ... Sebaceous carcinoma of the eyelid can invade the orbit of the eye and frequently metastasize, leading to death. Tumors at other ...
Ceruminous gland adenocarcinoma. These tumors are rare, but they are the most common malignant tumor of the ear canal of dogs, ... Sebaceous gland tumors. They are more common in middle-aged to older dogs than cats, with no sex predilection. They generally ... Ear tumors are growths associated with the dogs ear and the most common include ceruminous gland adenoma or adenocarcinoma, ... Radiation therapy in large or incompletely excised masses (ceruminous gland adenocarcinoma). Home Care and Prevention. Follow ...
"Radiotherapy for localized sebaceous carcinoma of the eyelid: a retrospective analysis of 83 patients, Journal of Radiation ... Sebaceous adenocarcinoma of the eyelid. prophylactic neck irradiation with doses of 44-50.5 Gy and reported Int Ophthalmol Clin ... Sebaceous adenocarcinoma of the eyelid. prophylactic neck irradiation with doses of 44-50.5 Gy and reported Int Ophthalmol Clin ... sebaceous glands in the caruncle [3]. Typical finding of sebaceous However, due to advanced age, presence of coexisting diseases ...
Sebaceous adenocarcinoma. Well differentiated mast cell tumours. Multilobular osteoma/osteosarcoma of bone ...
Sebaceous adenocarcinoma * Squamous cell carcinoma Notes: * In this current classification, sialoblastoma is designated as a ... Includes cystadenocarcinoma, intestinal type adenocarcinoma and mucinous adenocarcinoma * Basal cell adenocarcinoma * ... Polymorphous adenocarcinoma * (Mammary analogue) secretory carcinoma * Salivary duct carcinoma * Carcinoma ex pleomorphic ... Regarding the following parotid gland primary salivary gland adenocarcinoma, which of the pT category criteria in the 8th ...
Sebaceous carcinoma -- 17. Metastatic cutaneous adenocarcinoma -- 18. Zosteriform cutaneous metastasis -- Index.. Lane Catalog ... Sebaceous and sweat gland disorders -- Regional dermatology -- Racial skin differences -- The skin at different ages -- ...
Basal cell adenocarcinoma - Malignant sebaceous tumors - Cystadenocarcinoma - Low-grade cribriform cystadenocarcinoma - ... Mucinous adenocarcinoma - Oncocytic carcinoma - Salivary duct carcinoma - Adenocarcinoma, not otherwise specified - ... Acinic cell carcinoma, basal cell adenocarcinoma, clear cell adenocarcinoma, and epithelial-myoepithelial carcinoma are all low ... Sebaceous adenoma - Lymphadenoma - Ductal papilloma - Cystadenoma Malignant epithelial tumors. - Acinic cell carcinoma - ...
This tumor is thought to arise from sebaceous glands in the skin and, thus, may arise anywhere on the body where these glands ... Sebaceous gland carcinoma is an aggressive, uncommon, cutaneous tumor first well-described by Allaire in 1891. ... Hagedorn A. Adenocarcinoma of a meibomian gland. Arch Ophthalmol. 1934. 6:850-67. ... Sebaceous gland carcinoma resembles normal sebaceous glands. [16] One may reasonably speculate that sebaceous gland carcinoma ...
In this study, sebaceous adenocarcinoma was found to be almost twice as common in females as in males. This preponderance of ... In one particular study over a 22 year period, there were 48.1% of SCC, 32.6% of BCC, and 13.5% of sebaceous adenocarcinoma.12 ... The most common primary malignancy was BCC (84.0%), followed by sebaceous adenocarcinoma (10.2%) and SCC (3.4%) (Table 2). In ... The most common cancer was basal cell carcinoma (84.0%), followed by sebaceous adenocarcinoma (10.2%) and squamous cell ...
1. of or resembling sebum, fat, or tallow; fatty 2. secreting fat or a greasy lubricating substance Explanation of sebaceous ... Looking for sebaceous? Find out information about sebaceous. ... histopathologically diagnosed as sebaceous gland adenocarcinoma ... sebaceous. Also found in: Dictionary, Thesaurus, Medical, Wikipedia.. Related to sebaceous: sebum, sebaceous adenoma ... Lower Eyelid Reconstructive Surgery and Resection of Sebaceous Adenocarcinoma in a Dog ...
Sebaceous gland adenocarcinoma - malignant tumor derived from glands that empty into hair follicles ... Sebaceous gland adenoma - cat a benign tumor of the glands that empty into the hair follicle ...
E-cadherin and beta-catenin expression in sebaceous eyelid adenocarcinomas. Graefes archive for clinical and experimental ... sebaceous neoplasm; YSN: young sebaceous neoplasms; OSN: older sebaceous neoplasms. ... Sebaceous glands (SG) undergo cyclic growth, degeneration, and rest, which depend on cyclical changes of sebaceous gland stem ... SG: Sebaceous gland; HFSC: hair follicle stem cell; SGSC: sebaceous gland stem cell; DMBA: dimethylbenzanthracene; TPA: 12-o- ...
Mucinous adenocarcinoma cells present, comprising less than 50% of malignant cells. *Muir Torre syndrome w benign sebaceous ... The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), hodgkin and non-hodgkin ...
... sebaceous epithelioma, sebaceous adenoma, and. sebaceous adenocarcinoma. Sebaceous gland tumors are among the most common skin ... Sebaceous hyperplasia is often found peripheral to and phasing into sebaceous adenomas or adenocarcinomas and is likely a ... Ceruminous Gland Adenocarcinoma. Sebaceous hyperplasia/adenoma. Total cases/study. United States. 26.1. 21.6. 15.2. 14.7. 13.0 ... Sebaceous adenocarcinomas are rare in the cat and dog and appear to have a low potential for metastasis and recurrence. They ...
Variants include basaloid squamous cell carcinoma, superficial spreading cancer, sebaceous cancer, adenosquamous cancer, and ... Uncommon histologic types include adenocarcinoma, lymphoma, and sarcoma.. Studies have reported that tumor margins are usually ...
  • Histological examination of the exenteration specimen showed a 35 × 30 × 18 mm tumour arising in the region of the lacrimal gland, which had been entirely replaced by sebaceous carcinoma, with only a small focus of ductal tissue being present at the margin of the tumour at one point. (bmj.com)
  • Immunohistochemistry revealed strongly positive staining for epithelial membrane antigen (EMA) but negative staining with anticytokeratin, indicating the carcinoma to be of sebaceous origin (Fig 2 ). (bmj.com)
  • Sebaceous neoplasms (SN) may appear sporadically in the general population but may also be part of the Muir-Torre variant of Lynch syndrome (MT-LS). (cdc.gov)
  • The skin of the neonate differs from that of the adult, in that it is thinner, delicate, has weaker intercellular attachments and produces fewer sweat and sebaceous gland secretions and is more susceptible to several infections. (thefreedictionary.com)
  • Miller describes how they work: "Spot treatments work either by spreading over the dogs entire skin surface or by being absorbed through the skin at the point of application, circulating through the blood, and being transported back to the skin over the whole body through the sebaceous gland secretions. (freethesaurus.com)