Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
Carcinoma, Pancreatic Ductal
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Gene Expression Regulation, Neoplastic
Carcinoma, Squamous Cell
Neoplasms, Multiple Primary
Tumor Cells, Cultured
Carcinoma, Signet Ring Cell
Mammary Neoplasms, Experimental
Adenocarcinoma, Clear Cell
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
Ampulla of Vater
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
Common Bile Duct Neoplasms
Tissue Array Analysis
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Carcinoma, Non-Small-Cell Lung
Carcinoma, Acinar Cell
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Carcinoma in Situ
Receptor, Epidermal Growth Factor
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Reverse Transcriptase Polymerase Chain Reaction
Tumor Suppressor Protein p53
Gene Expression Profiling
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Cell Transformation, Neoplastic
Prostatic Intraepithelial Neoplasia
A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 22.214.171.124.
Carcinoma, Large Cell
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Combined Modality Therapy
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Carcinoma, Small Cell
Neoplasm Recurrence, Local
Oligonucleotide Array Sequence Analysis
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Tomography, X-Ray Computed
Antineoplastic Combined Chemotherapy Protocols
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
Loss of Heterozygosity
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
Antigens, Tumor-Associated, Carbohydrate
Pleural Effusion, Malignant
A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.
In Situ Hybridization, Fluorescence
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Sensitivity and Specificity
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Jaagsiekte sheep retrovirus
Genes, Tumor Suppressor
Drug Resistance, Neoplasm
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Proportional Hazards Models
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Disease Models, Animal
Pulmonary Adenomatosis, Ovine
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma. (1/35)AIMS: Regulation of cell cycle progression is a fundamental control process, linked to cellular differentiation and apoptosis in normal tissues. p21(WAF1) is a nuclear protein that regulates cell cycle progression. p21(WAF1) can be transcriptionally upregulated by p53, but may be activated independently of p53-for example, during terminal differentiation. Loss of topological control of p21(WAF1) expression is an early feature of malignancy in the colorectal system. Similar to the colonic mucosa, sebaceous glands contain cells that are constantly going through a process of cell division, differentiation, and cell death. This study investigated the expression of p53, p21(WAF1), and the proliferation marker Ki67 in normal sebaceous glands, sebaceous adenoma, sebaceoma, and sebaceous carcinoma. METHODS: Serial sections were stained with monoclonal antibodies to p21(WAF1), p53, and Ki67 (MIB1) using standard immunohistochemical techniques. RESULTS: In normal sebaceous glands, p21(WAF1) positive cells were only seen within the differentiating compartment, which was spatially distinct from the cycling peripheral Ki67 positive cells. In sebaceous adenoma and sebaceoma, topological control was maintained, with the distribution of markers being similar to that seen in normal sebaceous glands. Loss of topological control of markers of cellular control was seen in sebaceous carcinoma only. This contrasts with colonic tumours, in which loss of p21 compartmentalisation is seen in adenomas at an early stage of tumour progression. CONCLUSION: This work confirms the hypothesis that the dysregulation of cell cycle progression is an important process in the development of malignancy within sebaceous glands, although loss of topological control was seen only in sebaceous carcinoma. (+info)
Immunohistochemical staining for adipophilin, perilipin and TIP47. (2/35)BACKGROUND: The presence of lipid in the cell cytoplasm is useful for supporting the diagnosis of sebaceous gland carcinoma (SGC). Currently this requires histochemical stains that are carried out on frozen sections of unprocessed tissue. Recently, several anti-adipocytic antibodies that recognise proteins associated with lipid vesicles have been described. These antibodies can be applied to paraffin-wax sections. AIM: To assess the ability of anti-adipocytic antibodies to identify intracytoplasmic lipid in SGC. METHODS: Immunohistochemistry with a monoclonal antibody to adipophilin and polyclonal antibodies to perilipin and TIP47/PP17 was carried out on archival, formalin-fixed, paraffin-wax-embedded sections of 26 samples of SGC. The immunostaining was compared with 22 other eyelid tumours (11 basal cell carcinomas (BCC), 10 squamous cell carcinomas (SCC) and 1 Merkel cell tumour). RESULTS: Immunohistochemical staining was positive in 23, 10 and 2 cases of 26 SGC with adipophilin, perilipin and TIP47, respectively. The positive staining identified cytoplasmic lipid vesicles. Anti-adipophilin was positive in five other eyelid tumours (4 BCC and 1 SCC) staining small cytoplasmic granules that can be easily distinguished from the staining in SGC. CONCLUSIONS: Immunohistochemical staining for adipophilin and perilipin is a useful ancillary technique for the demonstration of lipid in SGC that may be applied to paraffin-wax sections. (+info)
Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia. (3/35)AIM: To determine the complications associated with mitomycin C (MMC) in the treatment of ocular surface neoplasia. METHODS: A retrospective and consecutive study of 100 eyes in 91 patients with ocular surface neoplasia treated with MMC in a single centre between November 1998 and January 2005. Outcome measures included complications of MMC and the treatment required for these complications. RESULTS: One to three 7 day cycles of topical MMC 0.04% four times a day were given to 59 eyes with localised corneal-conjunctival intraepithelial neoplasia (CIN), 19 eyes with diffuse CIN, six eyes with recurrent CIN, one eye with ocular surface squamous cell carcinoma, three eyes with primary acquired melanosis (PAM) with atypia, nine eyes with conjunctival malignant melanoma (MM), two eyes with sebaceous carcinoma with pagetoid spread, and one eye with recurrent atypical fibroxanthoma. Nine patients had bilateral CIN. 31 (34%) cases developed an allergic reaction to MMC and 14 (14%) eyes had epiphora secondary to punctal stenosis at a mean follow up period of 26.5 months. CONCLUSION: In the largest study looking at complications of topical MMC in the treatment of ocular surface neoplasia, allergic reaction and punctal stenosis are relatively common. Serious complications were not observed suggesting the safe use of MMC in mid-term follow up. (+info)
Activator protein-1 activity regulates epithelial tumor cell identity. (4/35)To examine the consequences of inhibiting activator protein-1 (AP-1) transcription factors in skin, transgenic mice were generated, which use the tetracycline system to conditionally express A-FOS, a dominant negative that inhibits AP-1 DNA binding. Older mice develop mild alopecia and hyperplasia of sebaceous glands, particularly around the eyes. When A-FOS was expressed during chemical-induced skin carcinogenesis, mice do not develop characteristic benign and malignant squamous lesions but instead develop benign sebaceous adenomas containing a signature mutation in the H-ras proto-oncogene. Inhibiting AP-1 activity after tumor formation caused squamous tumors to transdifferentiate into sebaceous tumors. Furthermore, reactivating AP-1 in sebaceous tumors results in a reciprocal transdifferentiation into squamous tumors. In both cases of transdifferentiation, individual cells express molecular markers for both cell types, indicating individual tumor cells have the capacity to express multiple lineages. Molecular characterization of cultured keratinocytes and tumor material indicates that AP-1 regulates the balance between the wnt/beta-catenin and hedgehog signaling pathways that determine squamous and sebaceous lineages, respectively. Chromatin immunoprecipitation analysis indicates that c-Jun binds several wnt promoters, which are misregulated by A-FOS expression, suggesting that members of the wnt pathway can be a primary targets of AP-1 transcriptional regulation. Thus, AP-1 activity regulates tumor cell lineage and is essential to maintain the squamous tumor cell identity. (+info)
A clinicopathological study of eyelid malignancies from central India. (5/35)BACKGROUND: Eyelid malignancies are completely treatable if detected early. The treatment depends on the invasiveness of the cancer which in turn depends on the type of malignancy. AIM: The aim of the study was to characterize the distribution of the types of eyelid malignancies in central India. SETTINGS AND DESIGN: The study was conducted in the Department of Plastic and Maxillofacial Surgery at a tertiary care hospital. MATERIALS AND METHODS: We report a series of 27 cases of eyelid malignancies. In the same case series, we also include a case of malignant hemangiopericytoma which is an extremely rare form of eyelid malignancy worldwide. STATISTICAL ANALYSIS: Depending on the underlying statistical distribution, either analysis of variance (ANOVA) or the Kruskal-Wallis (K-W) test was used to assess the differential distribution of these variables across the types of eyelid malignancies observed in this study. RESULTS: We observed that sebaceous cell carcinoma (approximately 37%) was almost as prevalent as basal cell carcinoma (approximately 44%) in the study subjects and had an earlier age of occurrence and a more rapid clinical course. CONCLUSIONS: Sebaceous cell carcinoma of the eyelid is almost as common as basal cell carcinoma in a large tertiary care centre in central India. (+info)
Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type. (6/35)The NH(2) terminus of LEF1 is frequently mutated in human sebaceous tumors. To investigate how this contributes to cancer, we did two-stage chemical carcinogenesis on K14DeltaNLef1 transgenic mice, which express NH(2)-terminally truncated Lef1 in the epidermal basal layer. Transgenic mice developed more tumors, more rapidly than littermate controls, even without exposure to tumor promoter. They developed sebaceous tumors, whereas controls developed squamous cell carcinomas. K14DeltaNLef1 epidermis failed to up-regulate p53 and p21 proteins during tumorigenesis or in response to UV irradiation, and this correlated with impaired p14ARF induction. We propose that LEF1 NH(2)-terminal mutations play a dual role in skin cancer, specifying tumor type by inhibiting Wnt signaling and acting as a tumor promoter by preventing induction of p53. (+info)
Role of fine needle aspiration cytology in diagnosis of eyelid sebaceous carcinoma. (7/35)Sebaceous carcinoma of the ocular adnexa is a malignant neoplasm which can exhibit aggressive local behavior and can metastasize to regional lymph nodes and distant organs. The neoplasm is known to masquerade as other benign and less malignant lesions, resulting in delay in diagnosis and relative high morbidity and mortality. Fine needle aspiration cytology (FNAC) of recurrent upper eyelid nodules treated elsewhere as chalazion was done. Cytological smears were suggestive of malignancy. Subsequently histopathology confirmed the diagnosis of sebaceous gland carcinoma. Eyelid reconstruction was done after histopathologically confirmed tumor-free margins. The article highlights the role of FNAC in early diagnosis and subsequent appropriate surgical management of eyelid sebaceous gland carcinoma to prevent recurrence and metastasis. (+info)
Adnexal skin tumors in Zaria, Nigeria. (8/35)BACKGROUND: Adnexal skin tumors share many features in common and differentiate along one line. Their detailed morphological classification is difficult because of the variety of tissue elements and patterns seen. They may be clinically confused with other cutaneous tumors. The aim of this report is to review and classify all adnexal tumors seen in a pathology department over a 16-year period. METHOD: A 16-year retrospective analysis of all adnexal skin tumors seen in a large University Teaching Hospital in Nigeria from January 1991- December 2006. All tissue specimens were fixed in 10% formalin, processed in paraffin wax and stained with Haematoxylin and Eosin. Histology slides were retrieved, studied and lesions characterized. RESULTS: Fifty-two adnexal tumors were seen, accounting for 0.9% of all cutaneous tumors seen within the same period. The median age was 33 years (range: 4 days-70 years). Clinical presentations varied from discreet swellings and nodules to ulcerated masses. Five patients presented with recurrent lesions. Only two cases had a clinical diagnosis of adnexal tumor. Twenty-four (46%) of the lesions were distributed in the head and neck region. Duration of symptoms was 2 months to 15 years (median: 12 months). Tumours of the sweat gland were the commonest--41 (78.8%); they comprised predominantly eccrine acrospiroma (17), characterized histologically by solid nests of round to polygonal cells with clear to eosinophilic cytoplasm, forming tubules in areas. Tumours of sebaceous gland were 7 (13.5%); they comprised mainly Nevus sebaceous of Jadassohn (6), composed of immature sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma. Tumours of hair follicle were 4 (7.7%) and included trichoepithelioma, characterized microscopically by multiple horn cysts and epithelial tracts connecting abortive pilar structures and a trichofolliculoma. Forty-six lesions (88.5%) were benign and six (11.5%) malignant. CONCLUSION: Adnexal skin tumors have distinct histological patterns which differentiates them from other cutaneous tumors. They are commonly distributed in the head, neck and trunk. The commonest variants are those of eccrine sweat gland origin. Malignant adnexal tumors are uncommon in our setting. (+info)
Expression of Shh and Wnt Signaling Pathway Proteins in Eyelid Sebaceous Gland Carcinoma: Clinicopathologic Study | IOVS | ARVO...
Purpose.: Activation or dysregulation of the Sonic hedgehog (Shh) and Wnt signaling pathways is suggested to lead to the development of many human malignancies. In this study, we investigated Shh and Wnt signaling protein expression in eyelid sebaceous gland carcinoma, and analyzed their correlation with clinical characteristics of the tumor. Methods.: Patients who underwent surgical resection of eyelid sebaceous gland carcinoma from 1999 to 2011 were recruited for the study. Immunohistochemical stainings of Shh signaling proteins (Shh, Gli-1, Gli-2, Gli-3, and ABCG2) and Wnt signaling proteins (Wnt, glycogen synthase kinase 3β, β-catenin, lipoprotein receptor-related protein [LRP], and c-Myc) were conducted. Results.: Thirty-seven cases of eyelid sebaceous gland carcinoma were included in this study. Twenty-nine patients showed no metastasis, and eight patients showed lymph node or distant metastasis. Shh, ABCG2, and Wnt proteins were more highly expressed in the group with metastasis than in ...
Cancer Stem Cell Markers in Eyelid Sebaceous Gland Carcinoma: High Expression of ALDH1, CD133, and ABCG2 Correlates With Poor...
Purpose.: To investigate the expression of cancer stem cell (CSC) marker proteins in eyelid sebaceous gland carcinoma and evaluate the clinical significance. Methods.: Archival tissue blocks from 50 cases of eyelid sebaceous gland carcinoma were tested via immunohistochemistry for 16 putative CSC markers. Levels of protein expression were analyzed alongside various clinicopathologic parameters such as metastasis-free survival time. Results.: Ten patients (20%) showed nodal or distant metastasis during the follow-up period (median, 35.2 months; range, 1-128 months) without any mortality in our series. Among the 16 markers, ALDH1, CD44, CD133, ABCG2, Sox4, Sox9, and slug were selected for candidates of CSC markers because they were frequently and predominantly found in the tumor cells compared with control tarsus cells, which showed negative or very low expression. Univariate analysis revealed that ALDH1, CD133, and ABCG2 were significantly associated with metastasis; patients with ALDH1- or ...
Sebaceous carcinoma in a mature teratoma of the ovary | Autopsy and Case Reports
The finding of a sebaceous carcinoma in a mature teratoma is rare in human pathology, with fewer than 10 cases currently reported in the literature. In this article, we report a case of sebaceous carcinoma in a mature teratoma of the ovary in a 59-year-old patient and discuss its histological findings.. ...
2020-2021 BCSC Basic and Clinical Science Course™
A primary characteristic of sebaceous carcinoma is pagetoid spread, the dissemination of both individual tumor cells and small clusters of tumor cells within the epidermis or conjunctival epithelium (see Fig 13-25B). The pagetoid areas do not have a direct connection to the main portion of the tumor. Another characteristic is the complete replacement of conjunctival epithelium by tumor cells, or sebaceous carcinoma in situ (see Fig 13-25C). This particular characteristic may make complete excision of sebaceous carcinoma challenging.. Treatment of sebaceous carcinoma typically involves wide local excision of the tumor. Widespread conjunctival epithelial involvement or deeply invasive tumors may require exenteration. Because it can be difficult to identify pagetoid spread or sebaceous carcinoma in situ on frozen sections, permanent sections are generally considered more reliable for evaluation of surgical resection margins than frozen sections of margins or Mohs technique. Before definitive ...
Sebaceous carcinoma - Wikipedia
Sebaceous carcinoma is an uncommon and aggressive malignant cutaneous tumor. Most are typically about 10 mm in size at presentation. This neoplasm is thought to arise from sebaceous glands in the skin and, therefore, may originate anywhere in the body where these glands are found. Because the periocular region is rich in this type of gland, this region is a common site of origin. The cause of these lesions are, in the vast majority of cases, unknown. Occasional cases may be associated with Muir-Torre syndrome.. This type of cancer usually has a poor prognosis because of a high rate of metastasis.. ...
Sebaceous Carcinoma of the Eyelid » New York Eye Cancer Center
Sebaceous carcinoma arises from the glands within the eyelids, caruncle, or eyebrow. They are more common in middle-aged patients.
Sebaceous Cell Carcinoma | Eyelid cancer
sebaceous cell carcinoma is found most frequently in the ocular region, which accounts for 75% of cases. The parotid gland is the most common site outside the ocular region, accounting for about 20% of cases.
Mark Ruchman, MD | Sebaceous Cell Carcinoma | Eyelid cancer
sebaceous cell carcinoma is found most frequently in the ocular region, which accounts for 75% of cases. The parotid gland is the most common site outside the ocular region, accounting for about 20% of cases.
Jason Aaron Sokol, MD | Sebaceous Cell Carcinoma | Eyelid cancer
sebaceous cell carcinoma is found most frequently in the ocular region, which accounts for 75% of cases. The parotid gland is the most common site outside the ocular region, accounting for about 20% of cases.
Global Skin Atlas - Diagnosis Detail
History: 55 year old woman with enlarging eyelid mass, about 2cm. Biopsy revealed sebaceous carcinoma which must be differentiated from squamous cell carcinoma (and sometimes from basal cell carcinoma) due to different clinical consequences. Sebaceous carcinoma of the periorbital region can be a diagnostic challenge for the clinican and pathologist. Immunohistochemistry may help in this regard ( see reference Sinard JH, Archives of Opthalmology, 117:776-83, 1999). ...
Most recent papers with the keyword sebaceous carcinoma | Read by QxMD
Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. In this context, sebaceous differentiation in MAC would support the first option. However, there are only 3 cases of MAC with sebaceous differentiation in the literature, and all of them were reported before adipophilin was available, which in the appropriate context (eg, testing clear cells for sebaceous vs eccrine differentiation) is very useful ...
Eye Cancer - CancerImportant.com
There are different types of cancer that affect various internal and external parts of the eye, although all these cancers are quite uncommon. Some of these are chloridal melanoma, iris melanocytoma, sebaceous carcinoma of the eyelid and iris melanoma are
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Loss of p21WAF1 compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma | Journal...
Our work has confirmed previous reports demonstrating the expression of Ki67, p53, and p21WAF1 in topologically distinct compartments in normal sebaceous glands. The expression of p21WAF1 in the absence of p53 positivity in the differentiating compartment of normal sebaceous glands is consistent with previous work indicating that p53 independent upregulation of p21WAF1 is associated with cellular differentiation.1-3,5-7 p21WAF1 positivity of postmitotic cells immediately adjacent to the proliferating compartment is consistent with a role for p21WAF1 in early differentiation, perhaps initiating cell cycle arrest.. In sebaceous adenoma and sebaceoma, both benign proliferations of the sebaceous glands, topological control was maintained, with the distribution of markers being similar to that seen in normal sebaceous glands, although the proliferative compartment was expanded.. The complete loss of compartmentalisation of markers seen in the sections of sebaceous carcinoma suggests loss of ...
Letters to the Editor: Case Report: Sebaceous Cell Carcinoma of the Upper Eyelid in an Older Patient - American Family Physician
to the editor: Sebaceous cell carcinoma of the eyelid is the fourth most common malignancy in the periocular region in the United States (basal cell carcinoma, squamous cell carcinoma, and melanoma are the leading three causes) and the second most common malignancy in China (basal cell carcinoma is the leading cause).1,2 Diagnosis and therapy tend to be delayed because sebaceous carcinoma is often mistaken for benign entities such as chalazion, conjunctivitis, or blepharitis.3. A 74-year-old woman presented to her ophthalmologist with conjunctival erythema and slight tenderness of her upper eyelid. She was diagnosed with conjunctivitis and prescribed erythromycin 0.5% ophthalmic ointment. At her one-month follow-up visit, she continued to have erythema and had also developed a small tender papule. A diagnosis of chalazion was made, and the patient was instructed to continue her antibiotic ointment and to apply warm compresses four times daily to the eye. At her two-month follow-up visit, the ...
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Sebaceous carcinoma - Dermatologist in Basking Ridge, Morristown, & Elizabeth, NJ
Most patients diagnosed with SC are treated with surgery. Two types of surgery are used to remove SC:. Excision: During this surgery, the surgeon removes the tumor and some surrounding tissue that looks healthy. This helps to remove cancer that may have traveled to an area that still looks healthy. An area can look healthy if it contains just a few cancer cells.. Mohs surgery: Because many SCs develop on an eyelid or other area with little extra skin, Mohs (pronounced moes) surgery may be recommended. This specialized surgery is only used to treat skin cancer. This surgery allows the Mohs surgeon to remove less tissue yet remove the entire tumor.. During Mohs surgery, the Mohs surgeon cuts out the tumor plus a very small amount of healthy looking tissue surrounding the tumor. While the patient waits, the Mohs surgeon uses a microscope to look at what was removed. The surgeon is looking for cancer cells. If the Mohs surgeon finds cancer cells at the edge of the removed tissue, the surgeon will ...
ABHD5, PGRMC1 and FDFT1 are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically basal cell carcinoma (BCC) with clear cell features ...
Eye neoplasm - Wikipedia
Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be primary (starts within the eye) or metastatic cancer (spread to the eye from another organ). The two most common cancers that spread to the eye from another organ are breast cancer and lung cancer. Other less common sites of origin include the prostate, kidney, thyroid, skin, colon and blood or bone marrow. Tumors in the eye and orbit can be benign like dermoid cysts, or malignant like rhabdomyosarcoma and retinoblastoma. The most common eyelid tumor is called basal cell carcinoma. This tumor can grow around the eye but rarely spreads to other parts of the body. Other types of common eyelid cancers include squamous carcinoma, sebaceous carcinoma and malignant melanoma. The most common orbital malignancy is orbital lymphoma. This tumor can be diagnosed by biopsy with histopathologic and immunohistochemical analysis. Most patients with orbital lymphoma can be offered ...
Lirias: Papillomavirus infections
Papillomas or warts are easily recognized skin or mucous membrane tumors. They are common in wild species and are particularly well known in deer (Cosgrove and Fay 1981; Sundberg and Nielson 1981). Most of these tumors are caused by papillomaviruses (PVs). Tumors can become quite large and numerous and persist for prolonged periods, but they usually regress, providing the individual with long-term immunity to future infections. Occasionally, the tumors will progress to squamous cell carcinoma, adenosquamous carcinoma, or sebaceous carcinoma that will eventually kill the host if not treated. Specific mucosotropic PV types and those infecting immunodeficient individuals are prone to induce malignancies. Virtually all mammalian species are hosts for one of more PV. This chapter provides an overview of PV infections in mammals ...
Eyelid tumours | Shropshire Eye Care
Eyelid tumours are fortunately uncommon, and most are not cancers that can spread elsewhere in the body. However, if they are not treated, they will grow and ultimately cause damage to the eyelid and surrounding tissues. Surgery is the treatment of choice for all eyelid tumours and they should be removed promptly to ensure the best outcome. Surgical excision is almost always curative and the lesion can usually be removed without significant cosmetic impact, especially if done at an early stage. Although the diagnosis may be obvious at your consultation, in some cases a preliminary biopsy will be necessary to confirm the precise type of tumour prior to definitive treatment. This biopsy is performed under local anaesthetic and a small piece of the tumour is removed to be examined under a microscope.. ...
Primary Non-Hodgkins Lymphoma of the Eyelid | Asian Journal of Ophthalmology
Malignant tumours affecting the eyelid include basal cell carcinoma (85% to 95%), squamous cell carcinoma (approximately 5%), sebaceous carcinoma (1% to 5%), and malignant melanoma (1%). Non-Hodgkins lymphoma of the eyelid is rare. This report is of an 80-year-old woman who presented with diffuse left upper eyelid swelling, clinically suspected to be a haemangioma. Rare diseases should be considered in differential diagnoses because they have the potential for rapid systemic involvement and may need treatment that is different from that of other common diseases at the same site.. ...
Metastatic breast carcinoma mimicking a sebaceous gland neoplasm: a case report | Journal of Medical Case Reports | Peer review
Breast cancer is common in women and its metastases involve the skin in approximately one quarter of patients. Accordingly, metastatic breast cancer shown to be cutaneous through histology must be distinguished from a wide variety of other neoplasms as well as the diverse morphologic variants of breast cancer itself. We report the case of a 61-year-old Caucasian woman with cutaneous metastases of a bilateral ductal breast carcinoma that in histopathological examination mimicked an adnexal neoplasm with sebaceous differentiation. Against the background of metastatic breast carcinoma, dermatopathological considerations of sebaceous differentiation of skin lesions are presented and discussed focusing on the rare differential diagnosis of sebaceous carcinoma of the breast.
Use of endoscopic transorbital and endonasal approaches for 360° circumferential access to orbital tumors in: Journal of...
Between April 2014 and June 2019, 16 patients with orbital tumors underwent either ETOA or EEA at the authors institution. Based on the neuro-topographic four-zone model of the orbit with its tumor epicenter around the optic nerve in the coronal plane, ETOA (n = 10, 62.5%) was performed for tumors located predominantly superolateral to the nerve and EEA (n = 6, 37.5%) for those located predominantly inferomedial to the nerve. Eight patients (50%) presented with intraconal tumors and 8 (50%) with extraconal ones. The orbital tumors included orbital schwannoma (n = 6), cavernous hemangioma (n = 2), olfactory groove meningioma (n = 1), sphenoorbital meningioma (n = 1), chondrosarcoma (n = 1), trigeminal schwannoma (n = 1), metastatic osteosarcoma (n = 1), mature cystic teratoma (n = 1), sebaceous carcinoma (n = 1), and ethmoid sinus osteoma (n = 1). The clinical outcomes and details of surgical techniques were reviewed. ...
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Oman Journal of Ophthalmology : Table of Contents
Periocular sebaceous gland carcinoma: do androgen receptor (NR3C4) and nuclear survivin (BIRC5) have a prognostic significance? ...
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Ophthalmology: Eyelid tumor | Neoplasm resection with subsequent plastic repair of affected lid. Treatment in Germany |...
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Sebaceous adenoma = غدوم دهني
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Clinical, dermoscopic and reflectance confocal microscopy features of sebaceous neoplasms in Muir-Torre syndrome<...
TY - JOUR. T1 - Clinical, dermoscopic and reflectance confocal microscopy features of sebaceous neoplasms in Muir-Torre syndrome. AU - Moscarella, E.. AU - Argenziano, G.. AU - Longo, C.. AU - Cota, C.. AU - Ardigò, M.. AU - Stigliano, V.. AU - Mete, L. S.. AU - Donati, P.. AU - Piana, S.. AU - Silipo, V.. AU - Catricalà, C.. AU - Albertini, G.. AU - Zalaudek, I.. PY - 2013/6. Y1 - 2013/6. N2 - Background Muir-Torre syndrome (MTS) is an autosomal-dominant disorder characterized by the association of sebaceous tumors or keratoacanthomas with an early onset visceral cancer in the spectrum of Lynch syndrome. Observations A total of 20 sebaceous tumors including 18 sebaceous adenoma and two sebaceomas of six patients with MTS were analysed. Two main clinico-dermoscopic features were observed: (1) clinically pink to white papules/nodules with a central crater, dermoscopically characterized by radially arranged, elongated crown vessels surrounding opaque structureless yellow areas at times covered ...
basal cell carcinoma with adnexal differentiation 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
DNA was extracted from 86 lesions including 17 proliferating tricholemmal and trichilemmal tumors, 15 trichoblastomas, 7 trichoadenomas, 4 pilomatricomas, 1 pilomatrical carcinoma, 4 basal cell carcinomas (BCCs) with shadow cells, 2 trichofolliculomas, 3 BCCs with sebaceous differentiation, 9 sebaceous adenomas, 6 sebaceomas, 14 sebaceous carcinomas (both ocular and extraocular forms), 2 gigantic horns, and 2 apocrine mixed tumors with shadow cells and subjected to polymerase chain reaction with newly designed primers encompassing glycogen synthase kinase-3beta phosphorylation sites of the CTNNB1 gene ...
Declining incidence of eyelid cancers in Singapore over 13 years: population-based data from 1996 to 2008 | British Journal of...
Results There were a total of 160 male patients (48%) and 173 female patients (52%). The median age at diagnosis was 66 years (range 31-95) for male subjects and 67 years (35-99) for female subjects. The average annual age-standardised incidence rate of all eyelid cancers over the 13 years was 5.0 per million. A significant decrease in rates from 6.6 per million in the 1996-1998 period to 3.9 per million in the 2005-2008 period with an annual percentage change of 3.6% (95% CI −6.5 to 0.7%; p=0.02) was noted for women. The most common cancer was basal cell carcinoma (82%), followed by sebaceous gland carcinoma (11%) and squamous cell carcinoma (4%).. ...
Muir-Torre syndrome: A case of this uncommon entity<...
TY - JOUR. T1 - Muir-Torre syndrome. T2 - A case of this uncommon entity. AU - Weinstein, Andrew. AU - Nouri, Keyvan. AU - Bassiri-Tehrani, Shirley. AU - Flores, Francisco. AU - Jimenez, Gloria. PY - 2006/3/1. Y1 - 2006/3/1. N2 - A 69-year-old Hispanic woman presented for the evaluation of nodules on the head and back. In the past, she had been treated for basal cell carcinoma (BCC) of the face; the referring physician was concerned that the new lesions might also be BCC. The patient had an extensive past medical history. In addition to BCC, she had been treated for breast cancer, colon cancer, and cervical cancer prior to emigrating to the USA. Her colonic malignancy had been localized proximal to the splenic flexure. She also had a history of colonic polyps and distal colonic villous adenoma. She denied ever being treated with radiation. Further details of her medical history and cancer staging were not available. Her family history was significant for a sister with colon cancer and ...
Eyelid Tumors | Dean McGee Eye Institute
Benign and cancerous tumors of the eyelid are common. In sunny climates, the lower eyelids are a common location for skin cancers. New lesions of the eyelids and eyelid margins should be carefully assessed and frequently need to be biopsied. In general, early detection yields excellent results with removal and reconstruction. In advanced cases, more complex reconstruction may require grafting or rotation flaps to fully repair the area removed with the tumor.. ...
Best Puffy Eyelids Treatment in Ulhasnagar 3, Thane, Top 10 Puffy Eyelids Treatment Doctors in Ulhasnagar 3, Thane,Reviews |...
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Swollen eyelid toddler - Doctors answer your questions
Swollen eyelid toddler - My child is 11 months old and his left eyelid is very swollen and little red today. It started looking puffy yesterday and now it is much worse..? See yourMD first. I would recommend seeing your pediatrician first.
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Comprehensive guide that has all the information you need to know about Uneven eyelids. This article covers all the ways that you can fix this problem!
The Inside of My Eyelids
a personal list of elements that help me remember that any day will have some redeeming quality- often including something outdoors
The Cancer Family Syndrome Rare Cutaneous Phenotypic Linkage of Torres Syndrome<...
TY - JOUR. T1 - The Cancer Family Syndrome Rare Cutaneous Phenotypic Linkage of Torres Syndrome. AU - Lynch, Henry T.. AU - Lynch, Patrick M.. AU - Pester, Judith. AU - Fusaro, Ramon M.. PY - 1981/4. Y1 - 1981/4. N2 - Sebaceous neoplasia have been observed in members of four families exhibiting the cancer family syndrome (CFS). This disorder is characterized by adenocarcinomas, particularly involving the (proximal) colon, endometrium, and ovary; an excess of multiple primary cancer; early age of cancer onset; and autosomal dominant pattern of inheritance. Multiple adenomatous polyps are lacking in this disorder. In four patients from three of these cancer-prone kindreds, cutaneous lesions were accompanied by multiple visceral adenocarcinomas, fulfilling the criteria for Torres syndrome, a disease that heretofore has not shown notable familial clustering characteristic of the CFS. Therefore, the coexistence of rare sebaceous neoplasia and visceral cancer in CFS supports the notion that some ...
Eyelid Tumors With Reference to Lesions Confused With Squamous Cell Carcinoma: III. Keratoacanthoma | JAMA Ophthalmology | JAMA...
This article reports the results of a clinicopathologic study of 44 keratoacanthomas of the eyelid. This tumor characteristically has a rapid development and pr
Editorial: treatment of eyelid tumours. | British Journal of Ophthalmology
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Help! Is it a Lump, Cyst or Growth on my Dog? | Walkerville Vet
Hi Andrew, I have a 10 year old Yorkie/Maltese (her tummy skin is light coloured, but she has black hair). I noticed a growth on top of her head (about a fingers width away from her right eye) that started growing about a year ago and it has increased in size gradually (no fast growth within a month or anything like that). For your reference, it is now the size of two green peas. I recently gave her a haircut and started worrying more… At first I thought it was a skin tag, but the growth is black in colour. After reading your post, it looks very similar like the sebaceous adenoma (same size and bumpy look, except it is black in colour). It also seems to be attached to the head on one side only (you can move and lift the other side up). Recently, I started putting vitamin E oil on it (for 3 days only) because initially I thought it was a wart (I know it isnt a wart now), but the vitamin e oil seems to have irritated it because when she rubs her head on the floor or when I wipe it with tissue, ...
Sebaceous Glands - Pictures, Function, Types, Location | HubPages
The sebaceous glands are minute glands of the skin. It is distributed in the entire skin of the human body except for the palms of the hands and soles of the feet. Location, Pictures, Function...
Urdu How To Make Your Eyelids Bigger Naturally without Makeup
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2 Year Old, Swollen Eyelid? - Mamapedia™
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We have a 17 week old fox red lab, and just this weekend picked up an 11 week old black lab. All is good, until this morning I looked at the black lab
Familial adenomatous polyposis
... sebaceous cysts, and osteomata (benign bone tumors). The combination of polyposis, osteomas, fibromas and sebaceous cysts is ... particularly ampullary adenocarcinoma). Other signs that may point to FAP are pigmented lesions of the retina ("CHRPE- ...
List of MeSH codes (C04)
... adenocarcinoma, sebaceous MeSH C04.557.470.550.175 - adenoma, sweat gland MeSH C04.557.470.550.175.125 - acrospiroma, eccrine ... adenocarcinoma MeSH C04.557.470.200.025.030 - adenocarcinoma, bronchiolo-alveolar MeSH C04.557.470.200.025.045 - adenocarcinoma ... adenocarcinoma, sebaceous MeSH C04.557.470.200.025.152 - adrenocortical carcinoma MeSH C04.557.470.200.025.200 - carcinoid ... adenocarcinoma, mucinous MeSH C04.557.470.200.025.085 - adenocarcinoma, papillary MeSH C04.557.470.200.025.085.225 - carcinoma ...
Salivary gland tumour
... not otherwise specified Basal cell adenocarcinoma Sebaceous carcinoma Sebaceous lymphadenocarcinoma Cystadenocarcinoma Low- ... not otherwise specified Adenocarcinoma, not otherwise specified Myoepithelial carcinoma Carcinoma ex pleomorphic adenoma ... grade cribriform cystadenocarcinoma Mucinous adenocarcinoma Oncocytic carcinoma Salivary duct carcinoma Salivary duct carcinoma ... epithelial tumors Acinic cell carcinoma Mucoepidermoid carcinoma Adenoid cystic carcinoma Polymorphous low-grade adenocarcinoma ...
Low-grade serous adenocarcinomas resemble Fallopian tube epithelium, whereas high-grade serous adenocarcinomas show anaplasia ... sebaceous tumor, and struma ovarii can also be part of the dermoid cyst. They are treated with surgery and adjuvant platinum ... Mucinous tumors include mucinous adenocarcinoma and mucinous cystadenocarcinoma. Mucinous adenocarcinomas make up 5-10% of ... Clear-cell adenocarcinomas are histopathologically similar to other clear cell carcinomas, with clear cells and hobnail cells. ...
... the most common being colorectal adenocarcinoma. MTS results from defects in DNA mismatch repair genes, MLH1, MSH2, and MSH6, ... Sebaceous carcinoma, also known as sebaceous gland carcinoma (SGc), sebaceous cell carcinoma, and meibomian gland carcinoma is ... Sebaceous carcinoma is a neoplastic growth of sebaceous glands. It is predominantly seen in the head and neck region given the ... Sebaceous adenoma Sebaceous hyperplasia Sebaceoma List of cutaneous neoplasms associated with systemic syndromes Nelson, B. R ...
It also was expressed at high levels in differentiating cells such as hair follicles, epidermis and sebaceous glands. Wei et al ... miR-203 has been found overexpressed in pancreatic adenocarcinoma and shows correlation with poor prognosis in patients that ... "MicroRNA-203 Expression as a New Prognostic Marker of Pancreatic Adenocarcinoma". Ann Surg Oncol. 17 (12): 3120-8. doi:10.1245/ ...
Sebaceous hyperplasia - In this condition, small yellowish growths develop on the skin, usually on the face. This condition is ... The development of endometrial adenocarcinoma from endometrial hyperplasia is a typical example of how the effects of ... Atypical endometrial hyperplasia may represent an early neoplastic process which can lead to endometrial adenocarcinoma. ...
Hereditary nonpolyposis colorectal cancer
In HNPCC, the mean age of diagnosis of gastric cancer is 56 years of age with intestinal-type adenocarcinoma being the most ... sebaceous glands, keratoacanthomas) 3. Colorectal cancer with MSI-high pathology in a person who is younger than 60 years of ... and sebaceous neoplasms. Increased risk of prostate cancer and breast cancer has also been associated with Lynch syndrome, ... right-sided poorly differentiated cancers right-sided mucinous cancers adenocarcinomas in any location showing any measurable ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Sebaceous adenoma. *Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic ...
Black hairy tongue
Burning mouth syndrome
Temporomandibular joint dysfunction
International Classification of Diseases for Oncology
M8410/0 Sebaceous adenoma (C44._) M8410/3 Sebaceous adenocarcinoma (C44._) Sebaceous carcinoma M8413/3 Eccrine adenocarcinoma ( ... Basophil adenocarcinoma Mucoid cell adenocarcinoma M8310/0 Clear cell adenoma M8310/3 Clear cell adenocarcinoma, NOS Clear cell ... M8140/2 Adenocarcinoma in situ, NOS (M8140/3) Adenocarcinoma, NOS M8140/6 Adenocarcinoma, metastatic, NOS M8141/3 Scirrhous ... Parietal cell adenocarcinoma M8215/3 Adenocarcinoma of anal glands (C21.1) Adenocarcinoma of anal ducts M8220/0 Adenomatous ...
زونا - ویکیپدیا، دانشنامهٔ آزاد
Familial adenomatous polyposis
medulloblastoma] ,1%; Liver hepatoblastoma 1.6%; Bile ducts adenocarcinoma Low but increased; Stomach adenocarcinoma ,1% in ... sebaceous cysts, and osteomata (benign bone tumors). The combination of polyposis, osteomas, fibromas and sebaceous cysts is ... "Small bowel [duodenum or periampulla] carcinoma 4-12% [distal to duodenum] Rare; Pancreas Adenocarcinoma ~1%; Papillary thyroid ... particularly ampullary adenocarcinoma). Other signs that may point to FAP are pigmented lesions of the retina ("CHRPE- ...
Sebaceous glands within the lining secrete a liquid that is used for identification of members within a species. These sacs are ... Anal sac adenocarcinoma Hyena butter Howard E. Evans; Alexander de Lahunta (7 August 2013). Miller's Anatomy of the Dog - E- ... This is usually done in the case of recurrent infection or because of the presence of an anal sac adenocarcinoma, a malignant ...
List of skin conditions
... sebaceous epithelioma) Sebaceous adenoma Sebaceous carcinoma Sebaceous hyperplasia Sebaceous nevus syndrome Seboacanthoma ... Aggressive digital papillary adenocarcinoma (digital papillary adenocarcinoma, papillary adenoma) Apocrine gland carcinoma ... Nevus comedonicus syndrome Nevus sebaceous (nevus sebaceous of Jadassohn, organoid nevus) Nevus unius lateris Nodular basal ... Within the latter type, the hairs occur in structures called pilosebaceous units, each with hair follicle, sebaceous gland, and ...
A sebaceous adenoma is a cutaneous condition characterized by a slow-growing tumour usually presenting as a pink, flesh- ... Over time adenomas may transform to become malignant, at which point they are called adenocarcinomas. Most adenomas do not ...
Ceruminous glands are near the ear canals, and produce cerumen (earwax) that mixes with the oil secreted from sebaceous glands ... Sweat gland tumors include: Acrospiroma Aggressive digital papillary adenocarcinoma Apocrine gland carcinoma Ceruminoma ... Because both apocrine glands and sebaceous glands open into the hair follicle, apocrine sweat is mixed with sebum. Both ... Structure and Function of Eccrine, Apocrine and Sebaceous Glands (3rd ed.). pp. 539-544. ISBN 978-0723435716.CS1 maint: ...
They have more color than the labia majora and contain numerous sebaceous glands. They meet posteriorly at the frenulum of the ... adenocarcinomas, sarcomas and invasive extramammary Paget's disease. Squamous cell carcinomas represent the most common variant ... Other features of the vulva include the pudendal cleft, sebaceous glands, the urogenital triangle (anterior part of the ... Other features include the pudendal cleft, pubic hair, sebaceous glands, the vulval vestibule, and the urogenital triangle. The ...
Cysts (such as sebaceous cysts) are also referred to as tumors, even though they have no neoplastic cells. This is standard in ... "Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma". Int J Clin Exp Pathol ... Benign conditions that are not associated with an abnormal proliferation of tissue (such as sebaceous cysts) can also present ... "Promoter hypermethylation of multiple genes in early gastric adenocarcinoma and precancerous lesions". Hum. Pathol. 40 (11): ...
위키백과:미번역 문서/의학 - 위키백과, 우리 모두의 백과사전
en:Sebaceous carcinoma (4). *en:Seborrheic keratosis (13). *en:Shark attack (18) → 상어 공격 ... en:Adenocarcinoma of the lung (6). *en:Adenoidectomy (15). *en:Adhesion (medicine) (9) ...
... sebaceous carcinomas, microcystic adnexal carcinoma, Paget's disease of the breast, atypical fibroxanthoma, leiomyosarcoma, and ... Adenocarcinoma. *Aggressive digital papillary adenocarcinoma. *Extramammary Paget's disease. Ungrouped. *Merkel cell carcinoma ...
Structure and Function of Eccrine, Apocrine and Sebaceous Glands (3rd ed.). pp. 539-544. ISBN 978-0723435716. .. CS1 maint: ... Because both apocrine glands and sebaceous glands open into the hair follicle, apocrine sweat is mixed with sebum. ... that mixes with the oil secreted from sebaceous glands. Mammary glands use apocrine secretion to produce milk. ... Aggressive digital papillary adenocarcinoma. *Apocrine gland carcinoma. *Ceruminoma. *Cutaneous myoepithelioma. *Cylindroma. * ...
Adenocarcinoma. *Aggressive digital papillary adenocarcinoma. *Extramammary Paget's disease. Ungrouped. *Merkel cell carcinoma ...
Adenocarcinoma. *Aggressive digital papillary adenocarcinoma. *Extramammary Paget's disease. Ungrouped. *Merkel cell carcinoma ...
adenocarcinomas. (8140-8429). Gastrointestinal. *tract: Linitis plastica. *Familial adenomatous polyposis. *pancreas * ... The differential diagnosis includes sebaceous lymphadenoma and oncocytoma. *. Low magnification micrograph of a Warthin tumor ...
Cysts (such as sebaceous cysts) are also referred to as tumors, even though they have no neoplastic cells. This is standard in ... "Promoter hypermethylation of multiple genes in early gastric adenocarcinoma and precancerous lesions". Hum. Pathol. 40 (11): ... Benign conditions that are not associated with an abnormal proliferation of tissue (such as sebaceous cysts) can also present ... "Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma". Int J Clin Exp ...
List of vaginal tumors
Mucinous adenocarcinoma  Squamous papilloma yes vaginal micropapillomatosis  Endometrioid adenocarcinoma no [18 ...
Clinicopathological characteristics of breast sebaceous adenocarcinoma
Breast sebaceous adenocarcinoma should be distinguished from cancers such as skin sebaceous adenocarcinoma, lipid-rich ... The differences between breast sebaceous adenocarcinoma and skin sebaceous adenocarcinoma are as follows: First, in the case of ... a diagnosis of breast sebaceous adenocarcinoma can be made. The differences between breast sebaceous adenocarcinoma and lipid- ... Primary breast sebaceous adenocarcinoma is defined based on sebaceous differentiation in at least 50% of cells in the absence ...
Cases reported • Adenocarcinoma, Sebaceous
Sebaceous. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full ... Rapidly invading sebaceous carcinoma of the external auditory canal. A very rare case of a sebaceous carcinoma of the external ... Sebaceous carcinoma arising on actinic keratosis. We report two cases of sebaceous carcinoma arising on actinic keratosis. The ... A case of multiple sebaceous epithelioma: analysis of microsatellite instability. Sebaceous gland tumor is a rare disease that ...
General Surgery | Wake Forest Baptist Health
Polish Journal of Pathology - 2018
CV E. H. Chow Revised
Blackwells Five Minute Veterinary Consult Canine & Feline 4th Edition: Larry Patrick Tilley, Francis W K Smith: Hardcover:...
Adenocarcinoma, Renal.. Adenocarcinoma, Salivary Gland.. Adenocarcinoma, Skin (Sweat Gland, Sebaceous).. Adenocarcinoma, ... Adenocarcinoma, Anal Sac/Perianal.. Adenocarcinoma, Lung.. Adenocarcinoma, Nasal.. Adenocarcinoma, Pancreas.. Adenocarcinoma, ... Adenocarcinoma, Thyroid-Dogs.. Aggression, Fear-Cats.. Aggression, Fear/Defensive-Dogs.. Aggression, Food, Possessive and ... Ceruminous Gland Adenocarcinoma, Ear.. Chagas Disease (American Trypanosomiasis).. Chediak-Higashi Syndrome.. Chemodectoma. ...
Cancerous tumours of the eye - Canadian Cancer Society
Eye Inflammation (Blepharitis) in Cats | petMD
Eye Inflammation in Dogs | PetMD
Anterior + uveitis (incl posterior uveitis) Flashcards - OPTOM 450 | Brainscape
Rare Cancer Support Forum • Members
Rare Cancer Support Forum • Members
Sebaceous Carcinoma Fri Jan 12, 2018 1:32 pm. Lilichka1. 0. Adenocarcinoma metastatic origin breast/ apocrine neoplasm Thu Sep ... Aggresive digital papillary adenocarcinoma Fri Aug 11, 2017 1:12 pm. SallyL. 0. Merkel Cell Carcinoma Mon Jun 19, 2017 6:33 am ... Adenoid Cystic Carcinoma sebaceous gland, right arm Sat Nov 17, 2012 11:27 pm. ... Skin and Sweat & Sebaceous Gland Cancers. digital papillary, eccrine, apocrine, mucinous eccrine, microcystic adenexal ...
Ear Tumors in Dogs - PetPlace
Ceruminous gland adenocarcinoma. These tumors are rare, but they are the most common malignant tumor of the ear canal of dogs, ... Sebaceous gland tumors. They are more common in middle-aged to older dogs than cats, with no sex predilection. They generally ... Ear tumors are growths associated with the dogs ear and the most common include ceruminous gland adenoma or adenocarcinoma, ... Radiation therapy in large or incompletely excised masses (ceruminous gland adenocarcinoma). Home Care and Prevention. Follow ...
Muir-Torre syndrome | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program
Duodenal adenocarcinoma. 0006771 Sebaceous gland carcinoma. 0030410 Showing of 19 , View All. ... in affected people include sebaceous epitheliomas, sebaceous carcinomas (which commonly occur on the eyelids) and ... Sebaceous adenoma is the most characteristic finding in people with Muir-Torre syndrome. (MTS). Other types of skin tumors. ... Sebaceous carcinoma of the eyelid can invade the orbit of the eye and frequently metastasize, leading to death. Tumors at other ...
Radiotherapy for localized sebaceous carcinoma of the eyelid: a retrospective analysis of 83 patients, Journal of Radiation...
"Radiotherapy for localized sebaceous carcinoma of the eyelid: a retrospective analysis of 83 patients, Journal of Radiation ... Sebaceous adenocarcinoma of the eyelid. prophylactic neck irradiation with doses of 44-50.5 Gy and reported Int Ophthalmol Clin ... Sebaceous adenocarcinoma of the eyelid. prophylactic neck irradiation with doses of 44-50.5 Gy and reported Int Ophthalmol Clin ... sebaceous glands in the caruncle . Typical ﬁnding of sebaceous However, due to advanced age, presence of coexisting diseases ...
Approach to the Cancer Case: Staging--How and Why - WSAVA2008 - VIN
Pathology Outlines - Pathologic TNM staging of major salivary glands (AJCC 8th edition)
Sebaceous adenocarcinoma * Squamous cell carcinoma Notes: * In this current classification, sialoblastoma is designated as a ... Includes cystadenocarcinoma, intestinal type adenocarcinoma and mucinous adenocarcinoma * Basal cell adenocarcinoma * ... Polymorphous adenocarcinoma * (Mammary analogue) secretory carcinoma * Salivary duct carcinoma * Carcinoma ex pleomorphic ... Regarding the following parotid gland primary salivary gland adenocarcinoma, which of the pT category criteria in the 8th ...
Dermatologic Manifestations of Sebaceous Carcinoma: Background, Pathophysiology, Epidemiology
This tumor is thought to arise from sebaceous glands in the skin and, thus, may arise anywhere on the body where these glands ... Sebaceous gland carcinoma is an aggressive, uncommon, cutaneous tumor first well-described by Allaire in 1891. ... Hagedorn A. Adenocarcinoma of a meibomian gland. Arch Ophthalmol. 1934. 6:850-67. ... Sebaceous gland carcinoma resembles normal sebaceous glands.  One may reasonably speculate that sebaceous gland carcinoma ...
Books by Subject - Lane Medical Library - Stanford University School of Medicine
Head and Neck: Salivary gland tumors: an overview
Basal cell adenocarcinoma - Malignant sebaceous tumors - Cystadenocarcinoma - Low-grade cribriform cystadenocarcinoma - ... Mucinous adenocarcinoma - Oncocytic carcinoma - Salivary duct carcinoma - Adenocarcinoma, not otherwise specified - ... Acinic cell carcinoma, basal cell adenocarcinoma, clear cell adenocarcinoma, and epithelial-myoepithelial carcinoma are all low ... Sebaceous adenoma - Lymphadenoma - Ductal papilloma - Cystadenoma Malignant epithelial tumors. - Acinic cell carcinoma - ...
Incidence of eyelid cancers in Singapore from 1968 to 1995 | British Journal of Ophthalmology
In this study, sebaceous adenocarcinoma was found to be almost twice as common in females as in males. This preponderance of ... In one particular study over a 22 year period, there were 48.1% of SCC, 32.6% of BCC, and 13.5% of sebaceous adenocarcinoma.12 ... The most common primary malignancy was BCC (84.0%), followed by sebaceous adenocarcinoma (10.2%) and SCC (3.4%) (Table 2). In ... The most common cancer was basal cell carcinoma (84.0%), followed by sebaceous adenocarcinoma (10.2%) and squamous cell ...
Sebaceous | Article about sebaceous by The Free Dictionary
1. of or resembling sebum, fat, or tallow; fatty 2. secreting fat or a greasy lubricating substance Explanation of sebaceous ... Looking for sebaceous? Find out information about sebaceous. ... histopathologically diagnosed as sebaceous gland adenocarcinoma ... sebaceous. Also found in: Dictionary, Thesaurus, Medical, Wikipedia.. Related to sebaceous: sebum, sebaceous adenoma ... Lower Eyelid Reconstructive Surgery and Resection of Sebaceous Adenocarcinoma in a Dog ...
Sebaceous carcinoma of the eyelids: personal experience with 60 cases
Despite the fact that the clinical features of sebaceous carcinoma have been widely reported, the diagnosis was suspected ... Adenocarcinoma, Sebaceous / pathology* * Adenocarcinoma, Sebaceous / secondary * Adenocarcinoma, Sebaceous / therapy * ... Sebaceous carcinoma of the eyelids: personal experience with 60 cases Ophthalmology. 2004 Dec;111(12):2151-7. doi: 10.1016/j. ... Conclusions: Despite the fact that the clinical features of sebaceous carcinoma have been widely reported, the diagnosis was ...
Injection-Site Sarcoma (Vaccine-Site Sarcoma) in Cats - Page 2 of 3 - PetPlace
Activated Hair Follicle Stem Cells and Wnt/β-catenin Signaling Involve in Pathnogenesis of Sebaceous Neoplasms
E-cadherin and beta-catenin expression in sebaceous eyelid adenocarcinomas. Graefes archive for clinical and experimental ... sebaceous neoplasm; YSN: young sebaceous neoplasms; OSN: older sebaceous neoplasms. ... Sebaceous glands (SG) undergo cyclic growth, degeneration, and rest, which depend on cyclical changes of sebaceous gland stem ... SG: Sebaceous gland; HFSC: hair follicle stem cell; SGSC: sebaceous gland stem cell; DMBA: dimethylbenzanthracene; TPA: 12-o- ...
TUMORS OF THE SKIN
... sebaceous epithelioma, sebaceous adenoma, and. sebaceous adenocarcinoma. Sebaceous gland tumors are among the most common skin ... Sebaceous hyperplasia is often found peripheral to and phasing into sebaceous adenomas or adenocarcinomas and is likely a ... Ceruminous Gland Adenocarcinoma. Sebaceous hyperplasia/adenoma. Total cases/study. United States. 26.1. 21.6. 15.2. 14.7. 13.0 ... Sebaceous adenocarcinomas are rare in the cat and dog and appear to have a low potential for metastasis and recurrence. They ...
ICD-9-CM Diagnosis Code 199.1 : Other malignant neoplasm without specification of site
Tumors of the Skin in Cats - Cat Owners - Merck Veterinary Manual
Sebaceous gland adenocarcinomas are the rare malignant form of these tumors. They occur in middle-aged or older cats. Female ... Sebaceous Gland Tumors The sebaceous glands secrete oil (sebum) into the hair follicles and onto the skin. Tumors and tumor- ... Sebaceous gland hyperplasia is a benign overgrowth of sebaceous gland cells. These tumors are usually small (less than 0.4 ... Sebaceous gland adenomas are common benign tumors of cats and dogs. Persians are the breed most predisposed. They appear ...
Sweat gland lesions | DermNet NZ
Papillary adenocarcinoma. Papillary adenocarcinomas are uncommon skin cancers derived from eccrine tissue. They are typically ... Eccrine and apocrine glands, hair follicles and sebaceous glands (which produce sebum) are often referred to as epidermal ... Papillary adenocarcinoma, Apocrine adenocarcinoma, Adnexal carcinoma, Undifferentiated adnexal carcinoma, Microcystic adnexal ... Apocrine adenocarcinoma. Cancers derived from apocrine tissue are often described as adnexal carcinomas. Variants include:. * ...
Hypopharyngeal Cancer: Overview, Clinical Presentation, Etiology and Risk Factors
AdenomaTumorsCarcinomasNeoplasmsCell carcinomaEyelidDifferentiationBenignTumorCutaneousNeoplasmApocrinePrognosisDuctalAdenomasColorectalAdenoidInclude sebaceous cystsPoorly differentiatedConjunctivalCystsMalignanciesType of sebaceousCases of sebaceousFeatures of sebaceousDiagnosis of sebaceousDevelopment of sebaceousGlands are foundEpidermalCeruminous gland adenocarcinomaEpithelialNevus sebaceousMultiple sebaceousMuir-Torre SyCancersHair folliclesGland cellsSurgical excisionEpitheliumCancerMeibomianHyperplasiaCaruncleFoamy cytoplasmLobulesSalivary glandSyndrome characterizedProstatic adenocarcinoma
- Sebaceous adenoma is the most characteristic finding in people with Muir-Torre syndrome (MTS). (nih.gov)
- Ear tumors are growths associated with the dog's ear and the most common include ceruminous gland adenoma or adenocarcinoma, sebaceous gland tumor and basal cell tumor. (petplace.com)
- Pleomorphic adenoma, Warthin tumor, and mucoepidermoid carcinoma are commonly found in the parotid glands whereas polymorphous low-grade adenocarcinoma usually arises in minor glands. (atlasgeneticsoncology.org)
- Although sebaceous adenoma and epithelioma are more specific markers for Muir-Torre syndrome, an evaluation for this syndrome is advisable once sebaceous gland carcinoma is diagnosed. (medscape.com)
- Sebaceous gland tumors are comprised of sebaceous adenoma and sebaceous carcinoma. (freethesaurus.com)
- In contrast, sebaceous adenoma appears distinct from sebaceous carcinoma in that it is typically a distinctly circumscribed lobular tumor with mature sebocytes and basaloid germinative cells in the periphery. (clinicalpainadvisor.com)
- Muir-Torre syndrome (MTS) is a form of Lynch syndrome and is characterized by sebaceous (oil gland) skin tumors in association with internal cancers . (nih.gov)
- Other types of skin tumors in affected people include sebaceous epitheliomas, sebaceous carcinomas (which commonly occur on the eyelids) and keratoacanthomas . (nih.gov)
- Sebaceous gland tumors. (petplace.com)
- Many other tumors arising from NS lesions have been reported in the literature, including keratoacanthoma, apocrine cystadenoma, leiomyoma, and sebaceous cell carcinoma. (thefreedictionary.com)
- The sebaceous gland tumors constituted the largest group (42. (thefreedictionary.com)
- These types of eye tumors include basal cell carcinomas, squamous cell carcinomas and sebaceous adenocarcinomas. (henryford.com)
- There have been reports of malignant tumors as well like transmissible venereal tumors (TMTs), adenocarcinoma, squamous cell carcinoma, hemangiosarcoma, osteosarcoma, mast cell tumor and epidermoid carcinoma. (wearethecure.org)
- In high dose male and female rats groups, the proportion of animals having one or more of the following malignant follicular-cell thyroid tumors: papillary adenocarcinomas, follicular-cell carcinomas, papillary cystadenocarcinomas, or adenocarcinomas NOS, was significantly greater than the proportion in corresponding control groups. (nih.gov)
- The incidence of malignant tumors (squamous-cell carcinomas, basal-cell carcinomas, or sebaceous adenocarcinomas) of the skin and its associated glands were significantly increased among high dose rats of both sexes. (nih.gov)
- As dogs age and develop numerous sebaceous skin tumors, they are also more likely to develop these minimally invasive meibomian tumors. (vmcli.com)
- Extracolonic benign tumors include sebaceous cysts, desmoid tumors, and osteomas of the jaw. (thecardiologyadvisor.com)
- Sebaceous carcinoma (SC) has been termed the "great masquerader" of adnexal tumors. (clinicalpainadvisor.com)
- The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. (proteopedia.org)
- Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases. (biocare.net)
- The association of multiple tumors of the sebaceous glands with primary visceral carcinomas was described for the first time by torre in 1967. (rzweb.net)
- Most sebaceous gland carcinomas have no obvious etiology. (medscape.com)
- Histologic studies have suggested that periocular sebaceous gland carcinomas arise from the sebaceous glands in this region. (medscape.com)
- Increased expression of androgen receptor in the nucleus of periocular sebaceous carcinoma may indicate a greater likelihood of recurrence and help distinguish this entity from squamous cell and basal cell carcinomas. (medscape.com)
- Pathologically, 47% showed intraepithelial (pagetoid) involvement, 27% of sebaceous carcinomas arose from the meibomian glands, and 18% arose from both meibomian and Zeis glands. (nih.gov)
- However, the outcome for adenocarcinomas and squamous cell carcinomas is generally guarded. (wearethecure.org)
- A retrospective review of 1349 cases of sebaceous carcinomas recorded in the National Cancer Institute Surveillance, Epidemiology and End Results (NCI SEER) database between 1973 and 2004 revealed that the eyelids were the involved site for 38.7% of sebaceous carcinomas. (clinicalpainadvisor.com)
- In a review of 40 cases of sebaceous carcinomas patients presented anywhere from less than 1 year to more than 4 years after the onset of symptoms. (clinicalpainadvisor.com)
- Also, up to 50% of sebaceous carcinomas can involve pagetoid spread and may be missed depending on biopsy technique and section of tissue sample studied. (clinicalpainadvisor.com)
- To this end we screened 35 normal and 23 hyperplastic thymuses, 127 thymomas and 41 thymic carcinomas for the presence of sebaceous differentiation as defined by morphology and expression of adipophilin and androgen receptor (AR). (springermedizin.de)
- One primary thymic carcinoma showed morphology of sebaceous carcinomas (keratinizing and foam cells, calcifications, giant cells), a strong expression of adipophilin and AR together with squamous markers. (springermedizin.de)
- Testing for FGFR2 amplification might be warranted when searching for actionable genomic alterations in sebaceous carcinomas in the mediastinum and in other locations. (springermedizin.de)
- Sebaceous carcinoma is a relatively uncommon cutaneous malignancy which can mimic other malignant neoplasms, such as basal and squamous cell carcinomas, as well as benign processes, such as chalazions and blepharitis, resulting in delayed diagnosis and suboptimal treatment (2). (biocare.net)
- Of 25 sebaceous carcinomas, 23 (92%) were also labeled with a similar pattern (2). (biocare.net)
- It is especially helpful in identifying intracytoplasmic lipid vesicles in poorly differentiated sebaceous carcinomas in challenging cases such as small periocular biopsy specimens (2,3). (biocare.net)
- [ 25 ] Controversy exists regarding the prophylactic removal of a nevus sebaceous, but when malignant neoplasms are suspected, removal is warranted regardless. (medscape.com)
- Qiu W, Lei M, Li J, Wang N, Lian X. Activated Hair Follicle Stem Cells and Wnt/β-catenin Signaling Involve in Pathnogenesis of Sebaceous Neoplasms. (medsci.org)
- Abnormalities of sebaceous gland progenitor cells contribute to the development of sebaceous neoplasms, but little is known about the role of HFSCs during sebaceous neoplasm development. (medsci.org)
- Here, using dimethylbenzanthracene (DMBA) plus 12-o-tetradecanoyl phorbol-13-acetate (TPA) treatment developing sebaceous neoplasms (SNs) were identified with H&E and Oil red O staining. (medsci.org)
- We found hair follicle and epidermal cell markers were expressed in sebaceous neoplasms. (medsci.org)
- Furthermore, SOX-9 and CD34-positive HFSCs were located in the basal layer of sebaceous lobules within the sebaceous neoplasms. (medsci.org)
- Finally, Wnt10b/β-catenin signaling was activated within the basal cells of sebaceous lobules in the sebaceous neoplasms. (medsci.org)
- Collectively, our findings suggest that the abnormal activation of both HFSCs and Wnt10b/β-catenin signaling involves in the development of sebaceous neoplasms. (medsci.org)
- However, it remains unknown whether the renewal of sebaceous neoplasms (SNs) induced by TPA is dependent on HFSCs. (medsci.org)
- MTS is an autosomal dominant cancer syndrome characterized by multiple sebaceous and visceral neoplasms, the most common being colorectal adenocarcinoma. (wikipedia.org)
- It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. (bioportfolio.com)
- Individuals with MTS may present with one or more sebaceous gland neoplasms or visceral malignancies. (freethesaurus.com)
- Additionally, a personal or family history of visceral malignancy may aid in the diagnosis of sebaceous carcinoma given its association with Muir-Torre syndrome, an autosomal dominant genodermatosis that predisposes affected individuals to sebaceous neoplasms and visceral cancers. (clinicalpainadvisor.com)
- The cytologic findings of two cases of metastatic sebaceous carcinoma are described and compared to three cases of locally recurrent basal cell carcinoma . (lookfordiagnosis.com)
- The morphologic features of sebaceous carcinoma in FNAB smears appear to be distinct from those of basal cell carcinoma . (lookfordiagnosis.com)
- sebaceous carcinoma is misdiagnosed as chalazion, blepharoconjunc- Furthermore, despite a recent progress in reconstructive surgery, tivitis, and basal or squamous cell carcinoma. (deepdyve.com)
- [ 18 ] In these rare cases, the sebaceous gland carcinoma may fill the conjunctival epithelium and create the appearance of squamous cell carcinoma in situ. (medscape.com)
- Sebaceous carcinoma, also known as sebaceous gland carcinoma (SGc), sebaceous cell carcinoma, and meibomian gland carcinoma is an uncommon malignant cutaneous tumor. (wikipedia.org)
- But several other types like osteosarcoma, mast cell, sebaceous carcinoma, malignant fibrous histiocytoma, squamous cell carcinoma, mucoepidermoid carcinoma, anaplastic carcinoma and complex carcinoma have been reported. (wearethecure.org)
- We report a case of a man in whom urinary bladder transitional cell carcinoma, metachronous prostate adenocarcinoma and small cell lung carcinoma were diagnosed within an eighteen-month period. (biomedcentral.com)
- In renal cell carcinoma, hepatocellular carcinoma and metastatic adenocarcinoma, epithelial membrane antigen (EMA) is positive but synaptophysin is negative, while in ACC, EMA is negative. (thefreedictionary.com)
- Result: Excisional biopsy performed for the nasal mass and histopathology examination showed sebaceous cell carcinoma, Surgical removal of the nasal mass was done and nasal reconstruction with right paramedian forehead flap plus full thickness skin graft taken from the abdomen for reconstruction of the inner nose also was done, after two years patient came back with recurrent at same site. (sciepub.com)
- Conclusion: sebaceous cell carcinoma is an extremely rare in HIV patients, but should be considers for any skin tumor in HIV patient, follow up also needed for the risk of recurrent. (sciepub.com)
- Epidermal membrane antigen (EMA), a glycoprotein found in secretary mammary cells, can be used to help differentiate SC from basal cell carcinoma with sebaceous differentiation, as it would be negative to more weakly positive in the latter. (clinicalpainadvisor.com)
- Zurück zum Zitat Cardesa A, Nadal A, Alos L, Lloreta-Trull J, Ferlito A (2018) Sebaceous differentiation in squamous cell carcinoma of the larynx and adjacent pharynx: case report with review and discussion of the. (springermedizin.de)
- Sebaceous carcinoma of the eyelid develops most often on the upper eyelid close to the eyelash line. (cancer.ca)
- Sebaceous carcinoma of the eyelid can invade the orbit of the eye and frequently metastasize, leading to death. (nih.gov)
- editorial decision 24 May 2019) ABSTRACT The current study retrospectively analyzed the results of radiotherapy for clinically localized sebaceous carcin- oma of the eyelid.We reviewed records of 83 patients with histologically conﬁrmed sebaceous carcinoma who were treated radiotherapeutically between 1983 and 2015. (deepdyve.com)
- Typical ﬁnding of sebaceous However, due to advanced age, presence of coexisting diseases, or carcinoma of the eyelid is shown in Figure 1. (deepdyve.com)
- Typical ﬁnding of sebaceous carcinoma of the eyelid. (deepdyve.com)
- In the present study, we retrospectively analyzed the efﬁcacy Median/range 12 mm/4-35 mm and safety of radiotherapy for the treatment of clinically localized sebaceous carcinoma of the eyelid. (deepdyve.com)
- In one histologic series, 51% of cases reportedly arose from a specialized sebaceous gland of the eyelid, the meibomian gland. (medscape.com)
- To describe clinical features, management, and prognosis of sebaceous carcinoma of the eyelid and adjacent structures. (nih.gov)
- Sixty consecutive patients with sebaceous carcinoma of the eyelid and adjacent structures. (nih.gov)
- 1-5 Sebaceous carcinoma of the orbit more commonly occurs as secondary invasion from the eyelid but may occur as metastatic spread from elsewhere in the body. (bmj.com)
- The periocular region, which includes the meibomian, Zeis, and sebaceous glands of the caruncle and eyelid, is the most common site accounting for up to 75% of SGc. (wikipedia.org)
- 4 The prognosis of sebaceous gland carcinoma (SGC) is considered poorer than most other malignant eyelid tumours with a mortality second only to malignant melanoma (MM). (freethesaurus.com)
- A classical presentation of a sebaceous carcinoma is a gradually enlarging, painless papule, nodule or plaque on the upper or lower eyelid. (clinicalpainadvisor.com)
- sebaceous gland carcinoma adnexal carcinoma of the sebaceous glands, usually occurring as a slow-growing hard yellow nodule on the eyelid. (enacademic.com)
- Sebaceous carcinoma - overview covers diagnosis and treatments, including mohs surgery, for this rare skin cancer that often affects the eyelid. (rzweb.net)
- The World Health Organisation defines primary sebaceous carcinoma of the breast based on sebaceous differentiation in at least 50% of cells in the absence of any evidence of originating in the cutaneous adnexa . (termedia.pl)
- microsatellite instability , determined by examining dinucleotide CA repeats at the microsatellite loci, was observed in DNA from one sebaceous epithelioma but not from the other two sebaceous epitheliomas or from one basal cell epithelioma with sebaceous differentiation, suggesting that this condition is unlikely to be due to germ-line mutation of mismatch repair genes . (lookfordiagnosis.com)
- A very rare case of a sebaceous carcinoma of the external auditory canal with basal cell differentiation is presented. (lookfordiagnosis.com)
- Our aim was to investigate sebaceous differentiation in thymus tumours and to identify new actionable genomic alterations. (springermedizin.de)
- Zurück zum Zitat Ajaz B, Tran TA, Truong T, Manoucheri M (2013) Thymolipoma with sebaceous differentiation: a hitherto unreported variant of thymolipoma. (springermedizin.de)
- A malignant tumor composed of cells showing differentiation toward sebaceous epithelium. (bvsalud.org)
- Additionally, in cases of poorly differentiated sebaceous carcinoma in which sebaceous differentiation could not have been reliably interpreted in H&E sections, adipophilin highlighted sebocytes and xanthelasmas (2). (biocare.net)
- Diagnosis and therapy tend to be delayed because sebaceous carcinoma is frequently mistaken for more common benign entities, further complicating treatment of this aggressive malignancy. (medscape.com)
- On such imaging, masses seen within the layers of the skin are considered benign, and the differential diagnoses for such masses include sebaceous cysts and epidermal inclusion cysts. (thefreedictionary.com)
- Macular benign skin lesion: Nevus sebaceous of Jadassohn. (medscape.com)
- In that sebaceous carcinoma can mimick these relatively benign dieases, eye care specialists should be suspicious of this tumor in any patient with persistent conjunctivitis. (rzweb.net)
- Sebaceous gland tumor is a rare disease that is a sign of muir-torre syndrome , an autosomal, dominantly inherited genodermatosis characterized by the presence of at least one sebaceous gland tumor and a minimum of one internal malignancy. (lookfordiagnosis.com)
- PURPOSE: To describe a previously unreported presentation of sebaceous carcinoma , an aggressive tumor that often presents insidiously with minimal symptoms and nonspecific signs. (lookfordiagnosis.com)
- Sebaceous gland carcinoma is an aggressive, uncommon, cutaneous tumor first well-described by Allaire in 1891. (medscape.com)
- [ 1 ] This tumor is thought to arise from sebaceous glands in the skin and, thus, may arise anywhere on the body where these glands exist, including the genitalia. (medscape.com)
- [ 14 ] In approximately 40% of cases, patients with Muir-Torre syndrome develop some type of sebaceous tumor before or concurrent with visceral malignancy. (medscape.com)
- Promotion of tumor metastasis and a poor clinical outcome have been associated with epigenetic inactivation of E-cadherin and subsequent loss of cell-to-cell adhesion in sebaceous carcinoma. (medscape.com)
- 1 oncocytotic adenocarcinoma in 641 cases occurred distant from the caruncle, and no malignant transformation of the tumor was found in the caruncular localization. (arvojournals.org)
- Ceruminous gland adenocarcinoma is the most common ear tumor in both cats and dogs. (animalcancersurgeon.com)
- Identification of adipophilin as a potential diagnostic tumor marker for lung adenocarcinoma. (biocare.net)
- Sebaceous carcinoma is an aggressive, malignant tumor arising from sebaceous glands of the skin adnexa (see the following image). (rzweb.net)
- Sebaceous carcinoma is a rare, highly malignant, and potentially lethal tumor of the skin. (rzweb.net)
- Background: Human Immunodefiency Virus (HIV) since the first case was reported is recognized as a major risk factor for development of different types of malignancies, Sebaceous carcinoma is a rare and aggressive form of cutaneous carcinoma and very rare in HIV Patients. (sciepub.com)
- Sebaceous carcinoma is a type of skin cancer found on areas of the skin that have sebaceous although this type of cutaneous cancer is a rare condition, it also is aggressive. (rzweb.net)
- E ditor ,-Sebaceous carcinoma is a rare primary neoplasm of the lacrimal gland and to the best of our knowledge only five cases have previously been reported. (bmj.com)
- Sclerosing Microcystic Adenocarcinoma of the Head and Neck Mucosa: A Neoplasm Closely Resembling Microcystic Adnexal Carcinoma. (diseaseinfosearch.org)
- Zurück zum Zitat Borczuk AC, Sha KK, Hisler SE, Mann JM, Hajdu SI (2002) Sebaceous carcinoma of the lung: histologic and immunohistochemical characterization of an unusual pulmonary neoplasm: report of a case and review of the literature. (springermedizin.de)
- carcinoma - Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell c. (enacademic.com)
- Eccrine and apocrine glands, hair follicles and sebaceous glands (which produce sebum ) are often referred to as epidermal adnexal structures. (dermnetnz.org)
- The clinical pathology data and follow-up information of two breast sebaceous adenocarcinoma cases are discussed below with retrospective analysis of information on the clinical and pathological features, diagnosis, differential diagnosis, treatment and prognosis of breast sebaceous adenocarcinoma patients highlighted in studies at home and abroad. (termedia.pl)
- Histological examination of the exenteration specimen showed a 35 × 30 × 18 mm tumour arising in the region of the lacrimal gland, which had been entirely replaced by sebaceous carcinoma, with only a small focus of ductal tissue being present at the margin of the tumour at one point. (bmj.com)
- It has been reported that adipophilin was expressed in 16 of 16 (100%) sebaceous adenomas with a specific pattern of membranous staining with strong uptake at the periphery of intracytoplasmic lipid vacuoles. (biocare.net)
- Conclusions The prevalence of MMR deficiency and Lynch syndrome in resected small bowel adenocarcinomas is at least comparable to prevalence in colorectal cancers, a finding relevant both for treatment (immunotherapy) and family management. (bmj.com)
- Izbicki JR, Schmitz R, Hoppen HO, Izbicki W and Troidl H: Effects of steroid hormone therapy on primarily xenotransplanted human colorectal adenocarcinomas. (3riversstadium.com)
- This uncommon and aggressive cancer originates in the oil glands in home medical testing related to sebaceous gland carcinoma: Colorectal cancer or colorectal carcinoma is cancer of the colon and/or rectum. (rzweb.net)
Include sebaceous cysts1
- Skin features include sebaceous cysts, hyperpigmented and cafe au lait spots. (proteopedia.org)
- On histology sebaceous carcinoma presents with disorderly invasion of the dermis by basaloid or squamoid cells and includes poorly differentiated sebaceous cells in ill-defined lobules. (clinicalpainadvisor.com)
- In the observed period, we excised 641 conjunctival probes where one oncocytotic adenocarcinoma was diagnosed. (arvojournals.org)
- Most of the times epidermoid cysts grow slowly and form out of the sebaceous glands. (thefreedictionary.com)
- 4 In addition, risk for several other malignancies is increased, including risk for small bowel adenocarcinomas, currently estimated to be between 0.4% and 12% for MLH1 and MSH2 variant carriers. (bmj.com)
Type of sebaceous1
- Meibomian glands are a type of sebaceous gland that lines the upper and lower eyelids and do not contain a follicle. (wikipedia.org)
Cases of sebaceous1
- A retrospective review of 1349 cases of sebaceous carcinoma. (sciepub.com)
Features of sebaceous1
- Despite the fact that the clinical features of sebaceous carcinoma have been widely reported, the diagnosis was suspected initially in only 32% of patients at first examination elsewhere and in only 50% at histopathologic examination elsewhere. (nih.gov)
Diagnosis of sebaceous1
- The diagnosis of sebaceous carcinoma is made histopathologically. (clinicalpainadvisor.com)
Development of sebaceous1
- Approximately 30 case reports have described the development of sebaceous carcinoma in a sebaceous nevus of Jadassohn. (medscape.com)
Glands are found3
- SGc originates from sebaceous glands in the skin and, therefore, may originate anywhere in the body where these glands are found. (wikipedia.org)
- 2) Sebaceous glands are found everywhere on the body where hair is found and are located adjacent to hair follicles with ducts, through which sebum flows. (freethesaurus.com)
- Sebaceous glands are found all over our bodies so this type of cancer can be diagnosed just about anywhere. (rzweb.net)
- Sebaceous glands (SGs) undergo cyclic renewal independent of hair follicle stem cells (HFSCs) activation while HFSCs have the potential to differentiate into sebaceous gland cells, hair follicle and epidermal keratinocytes. (medsci.org)
Ceruminous gland adenocarcinoma2
- Immunohistochemistry revealed strongly positive staining for epithelial membrane antigen (EMA) but negative staining with anticytokeratin, indicating the carcinoma to be of sebaceous origin (Fig 2 ). (bmj.com)
- Nevus sebaceous - Classification and external resources Nevus sebaceous on the scalp. (enacademic.com)
- Recurrent sebaceous carcinoma in Muir-Torre Syndrome. (clinicalpainadvisor.com)
- The majority of salivary gland cancers are adenocarcinomas. (wearethecure.org)
- Demodecosis is a skin disease caused by parasitic Demodex mites, principally Demodex folliculorum longus which live in the glands of hair follicles and Demodex folliculorum brevis which reside in sebaceous (oil) glands connected to hair follicles. (thefreedictionary.com)
- Under the microscope, we observed that the tumour cells were organised in a solid nest-like or leafy distribution and were composed of sebaceous gland cells and oval or fusiform cells (Fig. 2A). (termedia.pl)
- Sebaceous carcin- Radical surgical excision with a frozen section control by either a oma most commonly arises from the Meibomian glands anterior to standard method or Mohs micrographic surgery is the most com- the gray line and occasionally from the glands of Zeis or Moll and mon and effective treatment method of sebaceous carcinoma. (deepdyve.com)
- Small ulcerated yellow papule along the scar line of a previous surgical excision of a sebaceous carcinoma. (clinicalpainadvisor.com)
- Breast sebaceous adenocarcinoma is a rare and special type of invasive breast cancer, with as few as 21 cases reported at home and abroad. (termedia.pl)
- It is a cancer of the sebaceous glands. (cancer.ca)
- However, monogenic cancer predisposition syndromes, such as familial adenomatous polyposis (FAP) and Lynch syndrome, are known to be responsible for a proportion of small bowel adenocarcinomas. (bmj.com)
- We report the case of a female kidney transplant recipient with sebaceous carcinoma concurrent with colon cancer 10 years after transplantation. (rzweb.net)
- Sebaceous gland carcinoma is a very rare type of skin cancer. (rzweb.net)
- Future studies should clarify whether sebaceous gland IGF-I and survivin expressions are upregulated in sebaceous cell hyperplasia of acne vulgaris and whether isotretinoin treatment downregulates mTORC1, IGF-I, and survivin expression. (freethesaurus.com)
- sebaceous glands in the caruncle . (deepdyve.com)
- On histology, there are irregular lobules of different sizes with undifferentiated cells and distinct sebaceous cells with a foamy cytoplasm. (wikipedia.org)
- The sebaceous gland-like tumour cells were mostly located in the centre of the lobules or cellular nests. (termedia.pl)
- The potential of chemotherapy in the control of salivary gland adenocarcinoma has not been adequately explored. (wearethecure.org)
- sebaceous nevus syndrome - a syndrome characterized by a sebaceous nevus or nevi in a linear formation, present at birth and changing progressively throughout life. (enacademic.com)
- The tumor's stage according to the 1997 TNM staging system of prostatic adenocarcinoma was T1b. (biomedcentral.com)