Haploinsufficiency: A copy number variation that results in reduced GENE DOSAGE due to any loss-of-function mutation. The loss of heterozygosity is associated with abnormal phenotypes or diseased states because the remaining gene is insufficient.Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Telomerase: An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.Tumor Suppressor Proteins: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.Research Support, Non-U.S. Gov'tResearch Support, U.S. GovernmentRadiology: A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease.Radiology Department, Hospital: Hospital department which is responsible for the administration and provision of x-ray diagnostic and therapeutic services.Radiology, Interventional: Subspecialty of radiology that combines organ system radiography, catheter techniques and sectional imaging.Teleradiology: The electronic transmission of radiological images from one location to another for the purposes of interpretation and/or consultation. Users in different locations may simultaneously view images with greater access to secondary consultations and improved continuing education. (From American College of Radiology, ACR Standard for Teleradiology, 1994, p3)Visual Cortex: Area of the OCCIPITAL LOBE concerned with the processing of visual information relayed via VISUAL PATHWAYS.Evoked Potentials, Visual: The electric response evoked in the cerebral cortex by visual stimulation or stimulation of the visual pathways.Visual Perception: The selecting and organizing of visual stimuli based on the individual's past experience.Medical Illustration: The field which deals with illustrative clarification of biomedical concepts, as in the use of diagrams and drawings. The illustration may be produced by hand, photography, computer, or other electronic or mechanical methods.Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.Iothalamate Meglumine: A radiopaque medium used for urography, angiography, venography, and myelography. It is highly viscous and binds to plasma proteins.Digestive System Neoplasms: Tumors or cancer of the DIGESTIVE SYSTEM.Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Hematoxylin: A dye obtained from the heartwood of logwood (Haematoxylon campechianum Linn., Leguminosae) used as a stain in microscopy and in the manufacture of ink.Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Adenocarcinoma, Scirrhous: An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (From Dorland, 27th ed)Stomach Neoplasms: Tumors or cancer of the STOMACH.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Cell Line, Tumor: A cell line derived from cultured tumor cells.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.Tissue Survival: The span of viability of a tissue or an organ.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Point Mutation: A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.Mutation, Missense: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)Atlases as Topic: Collections of illustrative plates, charts, etc., usually with explanatory captions.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Apoptosis Regulatory Proteins: A large group of proteins that control APOPTOSIS. This family of proteins includes many ONCOGENE PROTEINS as well as a wide variety of classes of INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS such as CASPASES.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.NF-E2-Related Factor 2: A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.Carcinoma, Renal Cell: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Epitopes: Sites on an antigen that interact with specific antibodies.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Diagnostic Uses of Chemicals: Chemicals administered to patients in order to diagnose or study the pathology of medical conditions, diseases, or syndromes.Veterinary Medicine: The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.Omentum: A double-layered fold of peritoneum that attaches the STOMACH to other organs in the ABDOMINAL CAVITY.Thoracic Arteries: Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles, mammary gland and the axillary aspect of the chest wall.Access to Information: Individual's rights to obtain and use information collected or generated by others.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.

Borrmann's type IV gastric cancer: clinicopathologic analysis. (1/66)

OBJECTIVE: To determine whether there is a specific pattern of clinicopathological features that could distinguish Borrmann's type IV gastric cancer from other types of gastric cancer. DESIGN: A retrospective study of patients with advanced gastric cancer treated between 1985 and 1995. SETTING: The Department of Surgery, Sendai National Hospital, a 716-bed teaching hospital. PATIENTS: The clinicopathologic features of 88 patients with Borrmann's type IV carcinoma of the stomach were reviewed from the database of gastric cancer. The results were compared with those of 309 patients with other types of gastric carcinoma. MAIN OUTCOME MEASURES: Gender, age, tumour size, depth of invasion, histologic type, cancer-stromal relationship, histologic growth pattern, nodal involvement, lymphatic and vascular invasion, type of operation, cause of death and 5-year survival. RESULTS: Women were afflicted as commonly as men in the Borrmann's type IV group. These patients tended to be younger and to have larger tumours involving the entire stomach than patients with other types of cancer. Histologic type was commonly diffuse and scirrhous, and serosal invasion was prominent with infiltrative growth. Nodal involvement and lymphatic invasion were more common in patients with Borrmann's type IV than in those with other types of gastric cancer. The disease was advanced in most instances and a total gastrectomy was performed in 55% of the patients. The survival rate of patients with Borrmann's type IV tumour was lower than for patients with other types of gastric cancer (p < 0.005, log-rank test). CONCLUSIONS: In Borrmann's type IV gastric cancer, early detection and curative resection are crucial to extend the patient's survival. Aggressive postoperative chemotherapy is recommended when a noncurative resection is performed.  (+info)

Scirrhous cancer of the stomach which survived for more than five years after neoadjuvant chemotherapy with UFT (uracil and tegafur) and cisplatin. (2/66)

A 68-year-old man was diagnosed as having a scirrhous cancer of the stomach. Carcinomatous peritonitis was suspected on abdominal CT examination. Three courses of uracil and tegafur (UFT)/cisplatin (CDDP) chemotherapy were administered. The primary foci were reduced in size, then total gastrectomy was performed. Histological findings revealed a poorly differentiated adenocarcinoma with scirrhous invasion into the subserosa. Histological efficacy of the chemotherapy was judged to be grade 2. The patient has been alive without disease for more than five years after total gastrectomy. Neoadjuvant chemotherapy with UFT and CDDP may have contributed to the favorable clinical outcome in this patient.  (+info)

Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes. (3/66)

Scirrhous gastric cancer is often accompanied by metastasis to the peritoneum and/or lymph nodes, resulting in the highest mortality rate among gastric cancers. Mechanisms involved in gastric cancer metastasis are not fully clarified because metastasis involves multiple steps and requires the accumulation of altered expression of many different genes. Thus, independent analysis of any single gene would be insufficient to understand all of the aspects of gastric cancer metastasis. In this study, we performed global analysis on differential gene expression of a scirrhous gastric cancer cell line (OCUM-2M) and its derivative sublines with high potential for metastasis to the peritoneal cavity (OCUM-2MD3) and lymph nodes (OCUM-2MLN) in a nude mice model. By applying a high-density oligonucleotide array method, expression of approximately 6800 genes was analyzed, and selected genes were confirmed by the Northern blot method. In our observations in OCUM-2MD3 cells, 12 genes were up-regulated, and 20 genes were down-regulated. In OCUM-2MLN cells, five genes were up-regulated, and five genes were down-regulated. The analysis revealed two functional gene clusters with altered expression: (a) down-regulation of a cluster of squamous cell differentiation marker genes such as small proline-rich proteins [SPRRs (SPRR1A, SPRR1B, and SPRR2A], annexin A1, epithelial membrane protein 1, cellular retinoic acid-binding protein 2, and mesothelin in OCUM-2MD3 cells; and (b) up-regulation of a cluster of antigen-presenting genes such as MHC class II (DP, DR, and DM) and invariant chain (II) in OCUM-2MLN cells through up-regulation of CIITA (MHC class II transactivator). We then analyzed six gastric cancer cell lines by Northern blot and observed preferential up-regulation of trefoil factor 1, alpha-1-antitrypsin, and galectin 4 and down-regulation of cytidine deaminase in cells prone to peritoneal dissemination. Genes highly correlated with invasion or peritoneal dissemination of gastric cancer, such as E-cadherin or integrin beta4, were down-regulated in both of the derivative cell lines analyzed in this study. This is the first demonstration of global gene expression analysis of gastric cancer cells with different metastatic potentials, and these results provide a new insight in the study of human gastric cancer metastasis.  (+info)

Invasion activating caveolin-1 mutation in human scirrhous breast cancers. (4/66)

We looked for mutations in the caveolin-1 gene, encoding a critical molecule for membrane signaling to cell growth, in 92 primary human breast cancers, and we report here the identification of a mutation in caveolin-1 at codon 132 (P132L) in 16% of cases. The mutation-positive cases were mostly invasive scirrhous carcinomas. In cell lines expressing the same mutant of caveolin-1, we observed that the mutant Caveolin-1 expression seemed to induce cellular transformation and activation of mitogen-activated protein kinase-signaling pathway and to promote invasion-ability as well as altered actin networks in the cells. These results provide, for the first time, genetic evidence that a functioning Caveolin-1 mutation may have a role in the malignant progression of human breast cancer.  (+info)

Intestinal perforation due to metastasis of breast carcinoma, with special reference to chemotherapy: a case report. (5/66)

We report a case of small-bowel perforation due to metastatic carcinoma of the breast during chemotherapy. Partial resection of the small intestine and primary anastomosis were performed. Although the patient made a good recovery from panperitonitis, she died of the disease on the 55th postoperative day. Since perforation during chemotherapy results in an extremely poor prognosis, special caution during chemotherapy is needed for patients with possible gastrointestinal involvement with tumor.  (+info)

A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. (6/66)

Scirrhous carcinoma of the stomach is characterized by rapid growth with a vast fibrous stroma, high invasiveness, and substantially a poor prognosis. Little is known of the molecular pathogenesis of this disease. Members of the emerging family of the CCN gene (for connective tissue growth factor, cysteine-rich 61, nephroblastoma overexpressed) encode cysteine-rich secreted proteins with roles in human fibrotic disorders and cancer progression. Using targeted differential displays, we identified a novel variant of the CCN family member WISP1 (Wnt-induced secreted protein 1), named WISP1v, as overexpressed in scirrhous gastric carcinomas. Predicted protein of the WISP1v completely lacks a module of Von Willebrand type C that is thought to participate in protein complex formation. Ectopic expression revealed WISP1v to be a secreted oncoprotein inducing a striking cellular transformation and rapid piling-up growth. It is noteworthy that WISP1v transfectants enhanced the invasive phenotype of co-cultured gastric carcinoma cells, while wild-type WISP1 had no such potential. These findings suggest that CCN protein WISP1v is involved in the aggressive progression of scirrhous gastric carcinoma.  (+info)

Detection method and breast carcinoma histology. (7/66)

BACKGROUND: The association between method of detection and breast carcinoma histopathology has not been assessed adequately in a population-based setting. METHODS: Among women who were included in a population-based, case-control study of breast cancer, patients who were newly diagnosed with invasive breast carcinoma were identified from Wisconsin's statewide tumor registry. Only women age > or = 50 years were analyzed, because screening by mammography was not recommended before age 50 years at the time of the study. The breast tumors among these women (n = 2341 tumors) included the following histopathologies: lobular carcinoma (n = 206 tumors); ductal carcinoma, not otherwise specified (n = 1920 tumors); papillary carcinoma (n = 15 tumors); medullary carcinoma (n = 36 tumors); mucinous adenocarcinoma (n = 56 tumors); tubular adenocarcinoma (n = 41 tumors); invasive comedocarcinoma (n = 24 tumors); scirrhous adenocarcinoma (n = 15 tumors); and mixed ductal/lobular carcinoma (n = 28 tumors). RESULTS: Overall, women reported that 41% of tumors were detected by mammography, 48% of tumors were self detected, and 11% of tumors were detected by clinical breast examination (CBE). Detection by mammography was significantly more likely for women who had tubular carcinoma (83%; P < 0.001) and invasive comedocarcinoma (67%; P = 0.23) compared with women who had ductal carcinoma (40%). Mammography was significantly less likely to detect medullary carcinoma (17%) than ductal carcinoma (40%; P = 0.01). Lobular carcinoma was the only histopathology that, compared with ductal carcinoma, was detected significantly more often by CBE than by self detection. Mammography detected lobular carcinoma (42%) as frequently as ductal carcinoma (40%). However, the use of postmenopausal hormones may have modified these detection patterns: Among current users, mammography discovered a greater percentage of ductal carcinomas (51%) and fewer lobular carcinomas (36%) than nonusers. CONCLUSIONS: Among women age > or = 50 years, breast cancer detection by mammography, self detection, and CBE varied according to tumor histopathology.  (+info)

Scirrhous gastric carcinoma with mediastinal invasion in a dog. (8/66)

An 8-year-old male Rottweiler was presented for recurrent episodes of dysphagia and vomiting with chronic weight loss. Radiography revealed a mediastinal mass in the heart base region. Necropsy revealed a firm, white mediastinal mass extending along the distal esophagus, through the diaphragm, to the gastric cardia, leftward to the convex visceral aspect of the fundus, and rightward along the lesser curvature of the stomach to the pyloric antrum. The gastric lymph node was enlarged and the omentum contained several nodules. Histologically, deep fundic mucosa contained pleomorphic, vacuolated cells with intracytoplasmic mucin, which was hyaluronidase resistant. Neoplastic cells were cytokeratin positive and vimentin negative. Transmural invasion was evidenced by the presence of cytokeratin-positive cells between smooth muscle bundles of the gastric wall. The mediastinal mass was composed of clusters of neoplastic cells in a stroma of dense and loose connective tissue. Neoplastic cells were also within blood and lymphatic vessels, tracheobronchial and gastric lymph nodes, and around peripheral nerves. This carcinoma most likely arose from the gastric fundus and extended to the cardia, from where it advanced proximally to the mediastinum as well as further rightward along the lesser curvature, demonstrating an anatomic continuity suggestive of a direct invasion. Metastasis, evidenced by the presence of lymphatic, blood, and perineural tumor emboli, also occurred.  (+info)

Transforming growth factor β1 (TGF-β1) is a potent growth inhibitor for many cell types, including tumor cells. We recently have reported the establishment and characterization of two human gastric scirrhous carcinoma cell lines, HSC-39 and HSC-43. Here we examined the effect of TGF-β1 on the growth of these lines as compared to five other human gastric adenocarcinoma cell lines. Proliferation of HSC-39 and HSC-43 cells was strongly inhibited by TGF-β1, whereas the other gastric adenocarcinoma cell lines were unresponsive to TGF-β1. Both HSC-39 and HSC-43 cells gradually lost viability following exposure to TGF-β1. This response was dose dependent up to 4 ng/ml. When TGF-β1 was removed, the cells failed to exhibit regrowth, indicating an irreversible growth-inhibitory effect of this agent, leading to cell death. DNA fragments were observed consisting of multimers of approximately 180 base pairs 24 h after TGF-β1 treatment. The chromatin condensation of each cell line was confirmed by ...
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This phase II trial investigated the efficacy and tolerability of dovitinib in adults with advanced scirrhous gastric cancer who have disease progression
It seemed that the state of tyrosine phosphorylation was not altered by the expression of the caveolin-1 mutant. We next used a variety of phospho-specific antibodies (12) that have been generated against the activated forms of well-known signal transducers. Fig. 4d ⇓ shows that both intracellular MAPKs and p38-MAPK 4 were constitutively activated in the caveolin-1 mutant clones. On the other hand, the status of phosphorylation of AKT was not changed, although v-Src-transformed cells (SR3Y1) showed increased phosphorylation of AKT. Again, these experiments demonstrated the capacity for the mutant to drive cell transformation. These observations are compatible with previous reports showing that alteration of caveolin-1 function could be involved in the cellular transformation as a dominant negative effect of caveolin-1.. The mutation-positive cases of breast cancer were mostly involved in the pathologically invasive types such as scirrhous carcinomas (18) . Hence, we suspected that the ...
hypo symptoms - MedHelps hypo symptoms Center for Information, Symptoms, Resources, Treatments and Tools for hypo symptoms. Find hypo symptoms information, treatments for hypo symptoms and hypo symptoms symptoms.
Total, our results help the idea that variations in expression, localization and/or action (by way of phosphorylation) of SRSF1 and SRSF2 proteins get place
The German bank looks a better bet for the private equity firm than Friends Provident. Hypo is cheap and has a promising loan flow. But it s not ideal. Flowers is getting only 25%, and Hypo s discredited bosses will stay. Flowers may be feeling the pressure to do a deal.
Thank you for your replies. The time I feel worse is in the morning meals and snack and in the evening and I feel better overall but am exhausted from
I am 19 years old and I have SPD. I am hypo sensitive and I like to chew on things a lot. That is how I regulate myself. I just wanted to let you know
hyper/hypo - MedHelps hyper/hypo Center for Information, Symptoms, Resources, Treatments and Tools for hyper/hypo. Find hyper/hypo information, treatments for hyper/hypo and hyper/hypo symptoms.
TABLE-US-00001 TABLE 1 Table 1. Results summary of time spent over 180 mg/dL (TO180[min]) and number of hypoglycemic events (HYPO# [--]) for ten subjects in all nine experiments. Subject # Exp# 1 Exp# 2 Exp# 3 Exp# 4 Exp# 5 Exp# 6 Exp# 7 Exp# 8 Exp# 9 1 TO180 1107 1074 970 938 1006 947 919 1156 1018 Hypo# 0 0 0 0 0 0 0 0 0 2 TO180 993 587 412 221 487 189 156 1115 540 Hypo# 0 0 0 0 0 0 0 0 0 3 TO180 657 486 471 456 455 434 417 730 470 Hypo# 0 0 0 0 0 0 0 0 0 4 TO180 1140 587 480 466 57 0 0 1147 155 Hypo# 0 0 0 0 0 0 0 0 0 5 TO180 708 635 538 485 208 171 160 889 405 Hypo# 0 0 0 0 0 0 1 0 0 6 TO180 1149 766 596 520 635 417 259 1150 711 Hypo# 0 0 0 0 0 0 0 0 0 7 TO180 413 428 309 291 73 56 58 739 195 Hypo# 0 0 0 0 0 0 0 0 0 8 TO180 457 855 585 523 612 475 349 1098 743 Hypo# 0 0 0 0 0 0 0 0 0 9 TO180 153 385 319 269 265 181 120 477 324 Hypo# 0 0 0 0 0 0 0 0 0 10 TO180 492 596 444 421 233 119 88 885 423 Hypo# 0 0 0 0 0 0 0 0 0 As noted, Exp#8 (Experiment # 8, open loop with 40%) meal uncertainty, ...
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Table 3: Pharmacokinetic parameters of paclitaxel (PAC) and docetaxel (DOC) in plasma and ascitic fluid after an i.p. administration of drugs in crEL or PS-80 to nontumor rats [18 ...
In recent years, increasing research has focused on the relationship between cytokines and tumorigenesis. It has been suggested that cytokines may be a new therapeutic option for tumors (16-20). In our experiments, we demonstrated that IFN-λ1 inhibited the growth of gastric carcinoma cells in a concentration-dependent manner. These data suggest that IFN-λ1 may be a potential antitumor agent for the treatment of gastric cancer.. Impaired apoptotic induction and dysregulated cell cycle progression are important factors in cancer development. Accordingly, inhibition of cell cycle regulation is particularly useful in the treatment of cancer. In our in vitro study, we demonstrated the apoptosis-inducing effects of IFN-λ1 in gastric carcinoma cells using PI cell cycle analysis, Annexin V and PI staining as well as activated caspase-3. Our study showed that IFN-λ1 induced G1 phase arrest and apoptosis in the gastric carcinoma cells.. Experimental evidence suggests that apoptosis can be mediated by ...
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If you dont have, or know, anyone with diabetes, you may be asking what are hypos? If you do, youre almost certainly up to speed with what they mean. A hypo is the common term for low blood sugar, and symptoms include feeling faint, dizzy, hungry, trembly, anxious or having blurred vision. If its not treated and gets worse, it can even cause loss of consciousness and it can occasionally be fatal . The consequences can be severe, especially if youre driving or operating machinery at the time. Having hypos can reduce your quality of life and your confidence, and thats why this week is the first ever Hypoglycaemia Awareness Week, launched by the NHS .
Im thinking of getting a puppy for my daughter. Shes 2 years old but Im not sure what type of dog to get. I want something that wont get too big and Im thinking maybe hypo allergenic. Any suggestions on types of dogs, where to buy from, and pricing?
The Cancer Genome Atlas (TCGA) dataset for gastric cancer has shown that the gastric cancer populations with nonsynonymous KRAS, BRAF, or MEK1 mutations were relatively small (28 of 289, 24 of 289, and 7 of 289, respectively), and MEK1 Q56P or S72G mutations have not been identified in the TCGA dataset. In this study, we identified MEK1 mutations in poorly differentiated gastric cancer cell lines that were hypersensitive to MEK inhibitors and showed that these mutations have transformational abilities and that the growth of the cancer cells is dependent on these mutations. Specifically, the MEK1 S72Q mutation in the Okajima cell line is a novel activating mutation, whereas the MEK1 Q56P mutation in the OCUM-1 cell line has been previously reported by Choi and colleagues (17). In addition, a MEK1 Q56P mutation was identified in a clinical sample of a poorly differentiated gastric cancer; to the best of our knowledge, this is the first study in which a clinical sample of a MEK1 Q56P-mutated ...
Yeah. I did yes. So you know. You know, you pick up things, but there we are, because you always remember you go to casualty especially with somebody with diabetes who is in a hypo and one of the sisters here used to say, Go and get a Mars Bar for them. And you know it is only simple things like that but you remember, or a sugary drink. You know, to try to get them to drink it, milk is another thing, which you try and do. Marie biscuits. So, you know you tend to prepare yourself. Afterwards I was prepared for it, you know, I always had something like that. And make sure that you, I make sure that I eat fairly regularly at times, you know within a certain times. Not exactly heavy meals. But may, I have a little something to eat before I got to bed in the night because when you are at rest sometimes you dont want to go want to go hypo in the middle of the night, and you have got to experience being hypo as well. Because its really, ah it is something different. It is like walking on eggshells. ...
TS-5000Z味觉分析系统(电子舌)的开发历经数年,其研发团队从上世纪80年代开始研究味觉传感器,从初的交互敏感型响应,到现在可以实现对酸、甜、苦、咸等基本味道专一选择性的响应,其间发表论文数百篇,以下仅列举近年来的与大家分享: ...
I have made 2 batches of of plain hypo fixer for my toning process that has gotten milky/cloudy after fixing approximately 50 8x10 prints. I am using some old Zone VI hypo (anhydrous I assume since it is 673 grams for making a gallon). To that hypo, I add 120 grams of sodium sulfite. It is hot in the south and my fixing bath was 77 degrees, if that has anything to do with it. In my printing process, I use fixer 24 at 4 minutes, then wash and dry the prints for toning later. When I tone,
Buddy, If we are indeed supposed to be solving problems and not causing them, which I agree is true, then I suggest you read your own posts before you send them. The post in questions *sounded* very judgemental, to me at least and obviously some others here. To tell someone to just to count carbs better is like a slap in the face - "It is your fault, just do it right next time and you will be fine". Hello? We all do our best and sometimes it is not enough. Diabetes can be so variable, who knows what causes a hypo? Some days I eat the same things, do the same things, and one day it is high, one day it is low, another day it will be perfect. I am trying to figure out why and, after many years, am very happy to find what is usually a safe place to talk about the ups and downs. So you might consider the wide variety of ways a post can be interpreted before you post. And if you keep getting flack, maybe that is something to consider. :) Janine getting out her Kevlar ,Yes Greg I do go low. Dont get ...
¿Tienes un nivel elevado de ácido úrico? ¿Te duelen las articulaciones y se inflaman, como por ejemplo los dedos? Para reducir el ácido úrico, sería adecuado que, además de seguir las pautas médicas, mejoraras tu dieta con estos consejos. Te contamos cómo pueden ayudarte algunas verduras.
Adenocarcinoma, NOS M8140/6 Adenocarcinoma, metastatic, NOS M8141/3 Scirrhous adenocarcinoma Scirrhous carcinoma Carcinoma with ... Basophil adenocarcinoma Mucoid cell adenocarcinoma M8310/0 Clear cell adenoma M8310/3 Clear cell adenocarcinoma, NOS Clear cell ... Parietal cell adenocarcinoma M8215/3 Adenocarcinoma of anal glands (C21.1) Adenocarcinoma of anal ducts M8220/0 Adenomatous ... NOS M8210/3 Adenocarcinoma in adeonmatous polyp Adenocarcinoma in tubular adenoma Carcinoma in adeomatous polyp Adenocarcinoma ...
... adenocarcinoma, scirrhous MeSH C04.557.470.200.025.095.410 --- linitis plastica MeSH C04.557.470.200.025.105 --- adenocarcinoma ... adenocarcinoma, bronchiolo-alveolar MeSH C04.557.470.200.025.045 --- adenocarcinoma, clear cell MeSH C04.557.470.200.025.060 ... adenocarcinoma, mucinous MeSH C04.557.470.200.025.085 --- adenocarcinoma, papillary MeSH C04.557.470.200.025.085.225 --- ... adenocarcinoma, sebaceous MeSH C04.557.470.550.175 --- adenoma, sweat gland MeSH C04.557.470.550.175.125 --- acrospiroma, ...
It is considered an adenocarcinoma. There are two subtypes: sporadic (that is, non-hereditary) and hereditary. Both such ... Koenig divided the tumors into scirrhous, steatomatous, fungoid and medullary forms. Following the classification of the tumour ...
The LNCaP cancer cell line was established from a human lymph node metastatic lesion of prostatic adenocarcinoma. PC-3 and DU- ... ISBN 0-8070-2200-4. Adams J (1853). "The case of scirrhous of the prostate gland with corresponding affliction of the lymphatic ... The region of prostate gland where the adenocarcinoma is most common is the peripheral zone. Initially, small clumps of cancer ... Prostate cancer is classified as an adenocarcinoma, or glandular cancer, that begins when normal semen-secreting prostate gland ...
Micrograph of prostate adenocarcinoma, acinar type, the most common type of prostate cancer. Needle biopsy, H&E stain ... Adams J (1853). "The case of scirrhous of the prostate gland with corresponding affliction of the lymphatic glands in the ... The LNCaP cancer cell line was established from a human lymph node metastatic lesion of prostatic adenocarcinoma. PC-3 and DU- ... The region of prostate gland where the adenocarcinoma is most common is the peripheral zone. Initially, small clumps of cancer ...
MeSH-major] Adenocarcinoma, Scirrhous / drug therapy. Adenocarcinoma, Scirrhous / enzymology. Dihydrouracil Dehydrogenase (NADP ... MeSH-major] Adenocarcinoma, Scirrhous / drug therapy. Adenocarcinoma, Scirrhous / pathology. Antineoplastic Combined ... MeSH-minor] Adenocarcinoma, Scirrhous / metabolism. Adenocarcinoma, Scirrhous / pathology. Animals. Catalytic Domain / ... Core needle biopsy demonstrated scirrhous carcinoma.. *[MeSH-major] Adenocarcinoma, Scirrhous / drug therapy. Antibodies, ...
Adenocarcinoma. Stomach Neoplasms. Neoplasms by Site. Stomach Diseases. Linitis Plastica. Adenocarcinoma, Scirrhous. Neoplasms ... Adenocarcinoma, Scirrhous Linitis Plastica Stomach Neoplasms Stomach Diseases Neoplasms by Site Neoplasms Drug: TKI258 Phase 2 ... A Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Advanced Scirrhous Gastric Carcinoma Patients. The ... Advanced scirrhous gastric carcinoma. Gastric Cancer. Second-line or third-line treatment. VEGF. FGFR. Neoplasms. Gastric ...
adenocarcinoma (majority of cases) mucinous (colloid) adenocarcinoma signet ring adenocarcinoma scirrhous tumors neuroendocrine ... have a poorer prognosis than pure adenocarcinoma variants. References:. * Saclarides TJ, Szeluga D, Staren ED: Neuroendocrine ... Wolmark N, Rockette H, Wickerham DL, et al.: Adjuvant therapy of Dukes A, B, and C adenocarcinoma of the colon with portal- ... Wolmark N, Rockette H, Wickerham DL, et al.: Adjuvant therapy of Dukes A, B, and C adenocarcinoma of the colon with portal- ...
Adenocarcinoma, Scirrhous / genetics* * Adenocarcinoma, Scirrhous / pathology * Colonic Neoplasms / genetics * DNA Probes * DNA ... Frequent Amplification of the C-Met Gene in Scirrhous Type Stomach Cancer Biochem Biophys Res Commun. 1992 Nov 30;189(1):227-32 ... Among them, c-met amplification was detected in 5 gastric cancer cell lines, derived from scirrhous gastric carcinoma and in 5 ... 38%) of 13 scirrhous gastric carcinoma tissues. Furthermore, patients of gastric carcinoma with c-met amplification showed ...
Disease Scirrhous Adenocarcinoma For-Profit: $551.00 Non-Profit: $468.35 Qty:. Add to Cart ...
... adenocarcinoma cells with intermediate nuclei; (T) well-differentiated and less aggressive (low grade) adenocarcinoma cells ... N) Acinar and tubular, high grade; (O) acinar and cyst papillary, intermediate grade; (P) tubular and scirrhous, low grade. (Q- ... K-M) Different growth patterns of mammary adenocarcinoma in different PinX1+/- mice. (N-P) Different growth patterns and tumor ... adenocarcinoma cells with huge nuclei; (S) intermediately differentiated and aggressive (intermediate grade) ...
Breast cancer (scirrhous, intraductal, unspecified types) [35] * Cervical cancer. * Colon cancer (adenocarcinoma) ...
Moreover, the K-sam gene is amplified preferentially in poorly differentiated adenocarcinoma of scirrhous carcinoma. K-sam ... Among them, those most commonly implicated in both well-differentiated adenocarcinoma and poorly differentiated adenocarcinoma ... LOH on chromosome 18q (DCC locus) and LOH of the bcl-2 gene also are common events of well-differentiated adenocarcinoma. LOH ... Conversely, the development of poorly differentiated adenocarcinoma, in addition to changes in p53 and c-met genes, requires ...
In clinical practice, pancreatic cancer is synonymous with pancreatic ductal adenocarcinoma, which constitutes 90% of all ... pancreatic adenocarcinoma, as shown in the images below, is the second most common cause of death from cancer. ... The margins of the low-attenuating mass usually are poorly defined and correspond to a hypovascular scirrhous tumor. Pancreatic ... encoded search term (Pancreatic Adenocarcinoma Imaging) and Pancreatic Adenocarcinoma Imaging What to Read Next on Medscape. ...
Scirrhous adenocarcinoma is thought to arise near the pylorus and spread proximally.15 These tumors can eventually demonstrate ... Primary scirrhous adenocarcinoma of the stomach spreads predominantly in the submucosa and muscularis propria. This type of ... Scirrhous carcinoma of the pyloric channel and distal antrum. AJR Am J Roentgenol.1980;134:669-673. ... Scirrhous carcinoma of the stomach: Radiologic and endoscopic diagnosis. Radiology. 1990;175: 151-154. ...
Adenocarcinoma *Scirrhous Carcinoma *Ulcerating Carcinoma *Metastases Principles of Operative Procedures *I *II Postgastrectomy ...
Especially in these situations, immunohistochemistry may also help in distinguishing between HCC and other adenocarcinomas84. ... scirrhous hepatocellular carcinoma88; steatohepatic HCC89; HCC with lymphoid stroma, clear-cell variant of HCC and sarcomatous ... fibrolamellar versus scirrhous hepatocellular carcinoma. Histopathology. 2017;71:217-26. [ Links ] ...
CUB-domain-containing protein 1 (CDCP1) was shown to promote metastasis in scirrhous and lung adenocarcinomas as well as in ...
3. Adenocarcinoma with productive fibrosis (scirrhous, simplex, NST), 80 (invasive ductal carcinoma of no special type) ... productive fibrosis (scirrhous, simplex, NST) accounts for 80 of breast cancers and presents with macroscopic or microscopic ... especially when a locally advanced scirrhous carcinoma invades dermal lymph vessels in the skin to produce peau dorange and ...
Here we examined the effect of TGF-β1 on the growth of these lines as compared to five other human gastric adenocarcinoma cell ... Our results suggest that TGF-β1 induces cell death in human gastric scirrhous carcinoma cells in vitro which is mediated by ... Proliferation of HSC-39 and HSC-43 cells was strongly inhibited by TGF-β1, whereas the other gastric adenocarcinoma cell lines ... We recently have reported the establishment and characterization of two human gastric scirrhous carcinoma cell lines, HSC-39 ...
A tumor may be dense (scirrhous) or soft (medullary or cerebriform), depending on the degree of the stromas development. ... On this basis, cylindrical carcinoma (also called glandular cancer or adenocarcinoma) and squamous cell carcinoma are ... during pregnancy to prevent miscarriage developed vaginal adenocarcinomas as young women. Aflatoxins are natural mold ...
2007) CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma. Mol Cell Biol 27:7649- ... reported strong enhancement of migration of gastric scirrhous carcinoma cells in vitro by CDCP1 (37) but we saw little effect ... 2008) CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma. Am J Pathol 172:1729- ... The Y734F mutant form of CDCP1 also failed to confer anoikis resistance in lung adenocarcinoma cells and failed to promote ...
... this patient was a 64-year-old male whose gastric cancer had been diagnosed as a poorly differentiated scirrhous adenocarcinoma ... Signet ring cell histology is an independent predictor of poor prognosis in gastric adenocarcinoma regardless of tumoral ... and the one gastric cancer clinical sample with a MEK1 mutation was a poorly differentiated adenocarcinoma. Choi and colleagues ... these results suggest that gastric cancer with MEK1 mutations might be likely to have a poorly differentiated adenocarcinoma ...
... a human scirrhous gastric cancer cell line. Oncol Rep. 2017;37:2366-2374. ... ROS Inhibition Drives 5-Fu Resistance Dependent on Nrf2 Antioxidative Signaling Pathway in Gastric Adenocarcinoma. *Lu Wen ... ROS Inhibition Drives 5-Fu Resistance Dependent on Nrf2 Antioxidative Signaling Pathway in Gastric Adenocarcinoma. Dig Dis Sci ... a crucial role in the inhibition of 5-Fu-induced apoptosis resistance by removing ROS accumulation in gastric adenocarcinoma, ...
Adenocarcinoma, Scirrhous. An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense ... Adenocarcinoma, Follicular. An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. ( ... Adenocarcinoma In Situ. A lesion with cytological characteristics associated with invasive adenocarcinoma but the tumor cells ... Adenocarcinoma, Papillary. An adenocarcinoma containing finger-like processes of vascular connective tissue covered by ...
scirrhous adenocarcinoma 10.2. ERBB2 PGR 14. breast apocrine carcinoma 10.2. ERBB2 PGR ...
scirrhous adenocarcinoma 10.4. ERBB2 PGR 9. breast apocrine carcinoma 10.4. ERBB2 PGR ...
Monoclonal antibodies to adenocarcinoma cells, and, in particular, breast carcinoma cells, are produced by a hybridoma formed ... Anti-human pulmonary adenocarcinoma monoclonal antibody US5169774A (en) * 1984-02-08. 1992-12-08. Cetus Oncology Corporation. ... Breast carcinoma cell lines used included the following: MCF-7, derived from pleural effusion of scirrhous carcinoma [Soule, D. ... Anti-human pulmonary adenocarcinoma monoclonal antibody US7662383B2 (en) 1989-03-24. 2010-02-16. Aventis Pharma Deutschland ...
Adenocarcinoma, NOS M8140/6 Adenocarcinoma, metastatic, NOS M8141/3 Scirrhous adenocarcinoma Scirrhous carcinoma Carcinoma with ... Basophil adenocarcinoma Mucoid cell adenocarcinoma M8310/0 Clear cell adenoma M8310/3 Clear cell adenocarcinoma, NOS Clear cell ... Parietal cell adenocarcinoma M8215/3 Adenocarcinoma of anal glands (C21.1) Adenocarcinoma of anal ducts M8220/0 Adenomatous ... NOS M8210/3 Adenocarcinoma in adeonmatous polyp Adenocarcinoma in tubular adenoma Carcinoma in adeomatous polyp Adenocarcinoma ...
  • Other types: lymphoma, melanoma Epithelial: non glandular (squamous, transitional,papilloma Glandular(adenoma/ adenocarcinoma Seminoma tends to spread to lymph node along the iliac artery and aorta and highly radiosensitive i.e. responds well to radiotherapy. (studymode.com)
  • Gastric adenocarcinomas comprise one of the common types of cancers in Asian countries including Japan. (biomedcentral.com)
  • Comprehensive protein profiling of paired surgical specimens of primary gastric adenocarcinomas and nontumor mucosae derived from Japanese patients was carried out by means of two-dimensional gel electrophoresis (2D-EP) and liquid chromatography-electrospray ionic tandem mass spectrometry (LC-ESI-MS) to establish gastric cancer-specific proteins as putative clinical biomarkers and molecular targets for chemotherapy. (biomedcentral.com)
  • Gastric adenocarcinomas comprise one of the common types of cancers in Asian countries including Japan, being second only to lung cancer as to the number of deaths it causes. (biomedcentral.com)
  • We have classified the fibrotic stroma of rectal adenocarcinoma penetrating the muscularis propria, based on histologically identified stromal components. (bmj.com)
  • The morphological categorisation of fibrotic cancer stroma highlights the role of the stromal response in relation to the behaviour and host immune reactions of rectal adenocarcinoma and would be a useful tool for predicting patient prognostic outcome. (bmj.com)
  • Procollagen Type I C-peptide (PIP) has been extensively referenced in correlation studies between collagen levels and certain health disorders such as bone disease, alcoholic liver disease, liver cirrhosis, and scirrhous (Borrmann type IV) adenocarcinoma of the stomach. (clontech.com)
  • Like classic HCC, scirrhous HCC frequently develops in patients with liver cirrhosis, but there has been no report of synchronous occurrence of classic and scirrhous HCCs. (kowsarpub.com)
  • Here, we report synchronous classic and scirrhous HCCs in a 62-year-old man with early liver cirrhosis who underwent gadoxetic acid-enhanced and diffusion-weighted magnetic resonance imaging. (kowsarpub.com)
  • Scirrhous HCC similar to classic HCC is associated with liver cirrhosis. (kowsarpub.com)