Adenocarcinoma, Mucinous
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Adenocarcinoma, Papillary
Barrett Esophagus
A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
Carcinoma, Pancreatic Ductal
Adenocarcinoma, Bronchiolo-Alveolar
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
Cardia
Immunohistochemistry
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Esophagogastric Junction
Neoplasm Staging
Prognosis
Keratin-7
Gene Expression Regulation, Neoplastic
Carcinoma, Squamous Cell
Endometrial Neoplasms
Neoplasms, Multiple Primary
Precancerous Conditions
Tumor Cells, Cultured
Carcinoma, Signet Ring Cell
Carcinoma, Endometrioid
Mammary Neoplasms, Experimental
Adenocarcinoma, Clear Cell
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
Metaplasia
Immunoenzyme Techniques
Colorectal Neoplasms
Ampulla of Vater
Genes, ras
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
Common Bile Duct Neoplasms
Keratin-20
Tissue Array Analysis
Pancreaticoduodenectomy
Survival Rate
Neoplasm Metastasis
Lymphatic Metastasis
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Carcinoma, Non-Small-Cell Lung
Carcinoembryonic Antigen
Carcinoma, Acinar Cell
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Neoplasm Transplantation
Esophagus
Disease Progression
Survival Analysis
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Gastrectomy
Mice, Nude
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Mutation
Carcinoma in Situ
Receptor, Epidermal Growth Factor
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Kaplan-Meier Estimate
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Reverse Transcriptase Polymerase Chain Reaction
Biopsy
Fatal Outcome
Antigens, Neoplasm
Treatment Outcome
Mucins
Gastrointestinal Neoplasms
Tumor Suppressor Protein p53
Pancreatic Ducts
Gene Expression Profiling
Endometrial Hyperplasia
Keratins
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Cell Transformation, Neoplastic
Ovarian Neoplasms
Prostatic Intraepithelial Neoplasia
A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
ras Proteins
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.
Carcinoma, Large Cell
Neoplasms, Experimental
Fluorouracil
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
CA-19-9 Antigen
Mucin-2
Gastric Mucosa
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Hyperplasia
Carcinoma
Combined Modality Therapy
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Carcinoma, Small Cell
Adenoma, Villous
Neoplasm Recurrence, Local
Prostate
Oligonucleotide Array Sequence Analysis
Pancreas
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Tomography, X-Ray Computed
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Neuroendocrine
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Mucin-1
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
Loss of Heterozygosity
Blotting, Western
Cystadenocarcinoma
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Genes, erbB-1
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
Mesothelioma
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
Risk Factors
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Biopsy, Needle
Proto-Oncogene Proteins
Anal Sacs
Cystadenocarcinoma, Serous
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
Cell Division
Disease-Free Survival
Ki-67 Antigen
Cyclooxygenase 2
Follow-Up Studies
Antigens, Tumor-Associated, Carbohydrate
Chemotherapy, Adjuvant
HT29 Cells
Pleural Effusion, Malignant
Mucin-4
A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.
In Situ Hybridization, Fluorescence
Gastroesophageal Reflux
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Gene Amplification
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Sensitivity and Specificity
Urachus
Multivariate Analysis
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Carcinogens
Radiotherapy, Adjuvant
Up-Regulation
Pancreatitis, Chronic
Cystadenocarcinoma, Mucinous
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
Neoplasm Grading
Incidence
Colon
Carcinoid Tumor
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
DNA Methylation
Jaagsiekte sheep retrovirus
Intestinal Mucosa
Genes, Tumor Suppressor
Drug Resistance, Neoplasm
Base Sequence
Nitrosamines
Gene Expression
Genes, p53
Carcinosarcoma
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Proportional Hazards Models
Smad4 Protein
Mice, Transgenic
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Disease Models, Animal
Neoadjuvant Therapy
Pulmonary Adenomatosis, Ovine
Cadherins
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Histocytochemistry
Membrane Proteins
Epithelium
Borrmann's type IV gastric cancer: clinicopathologic analysis. (1/66)
OBJECTIVE: To determine whether there is a specific pattern of clinicopathological features that could distinguish Borrmann's type IV gastric cancer from other types of gastric cancer. DESIGN: A retrospective study of patients with advanced gastric cancer treated between 1985 and 1995. SETTING: The Department of Surgery, Sendai National Hospital, a 716-bed teaching hospital. PATIENTS: The clinicopathologic features of 88 patients with Borrmann's type IV carcinoma of the stomach were reviewed from the database of gastric cancer. The results were compared with those of 309 patients with other types of gastric carcinoma. MAIN OUTCOME MEASURES: Gender, age, tumour size, depth of invasion, histologic type, cancer-stromal relationship, histologic growth pattern, nodal involvement, lymphatic and vascular invasion, type of operation, cause of death and 5-year survival. RESULTS: Women were afflicted as commonly as men in the Borrmann's type IV group. These patients tended to be younger and to have larger tumours involving the entire stomach than patients with other types of cancer. Histologic type was commonly diffuse and scirrhous, and serosal invasion was prominent with infiltrative growth. Nodal involvement and lymphatic invasion were more common in patients with Borrmann's type IV than in those with other types of gastric cancer. The disease was advanced in most instances and a total gastrectomy was performed in 55% of the patients. The survival rate of patients with Borrmann's type IV tumour was lower than for patients with other types of gastric cancer (p < 0.005, log-rank test). CONCLUSIONS: In Borrmann's type IV gastric cancer, early detection and curative resection are crucial to extend the patient's survival. Aggressive postoperative chemotherapy is recommended when a noncurative resection is performed. (+info)Scirrhous cancer of the stomach which survived for more than five years after neoadjuvant chemotherapy with UFT (uracil and tegafur) and cisplatin. (2/66)
A 68-year-old man was diagnosed as having a scirrhous cancer of the stomach. Carcinomatous peritonitis was suspected on abdominal CT examination. Three courses of uracil and tegafur (UFT)/cisplatin (CDDP) chemotherapy were administered. The primary foci were reduced in size, then total gastrectomy was performed. Histological findings revealed a poorly differentiated adenocarcinoma with scirrhous invasion into the subserosa. Histological efficacy of the chemotherapy was judged to be grade 2. The patient has been alive without disease for more than five years after total gastrectomy. Neoadjuvant chemotherapy with UFT and CDDP may have contributed to the favorable clinical outcome in this patient. (+info)Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes. (3/66)
Scirrhous gastric cancer is often accompanied by metastasis to the peritoneum and/or lymph nodes, resulting in the highest mortality rate among gastric cancers. Mechanisms involved in gastric cancer metastasis are not fully clarified because metastasis involves multiple steps and requires the accumulation of altered expression of many different genes. Thus, independent analysis of any single gene would be insufficient to understand all of the aspects of gastric cancer metastasis. In this study, we performed global analysis on differential gene expression of a scirrhous gastric cancer cell line (OCUM-2M) and its derivative sublines with high potential for metastasis to the peritoneal cavity (OCUM-2MD3) and lymph nodes (OCUM-2MLN) in a nude mice model. By applying a high-density oligonucleotide array method, expression of approximately 6800 genes was analyzed, and selected genes were confirmed by the Northern blot method. In our observations in OCUM-2MD3 cells, 12 genes were up-regulated, and 20 genes were down-regulated. In OCUM-2MLN cells, five genes were up-regulated, and five genes were down-regulated. The analysis revealed two functional gene clusters with altered expression: (a) down-regulation of a cluster of squamous cell differentiation marker genes such as small proline-rich proteins [SPRRs (SPRR1A, SPRR1B, and SPRR2A], annexin A1, epithelial membrane protein 1, cellular retinoic acid-binding protein 2, and mesothelin in OCUM-2MD3 cells; and (b) up-regulation of a cluster of antigen-presenting genes such as MHC class II (DP, DR, and DM) and invariant chain (II) in OCUM-2MLN cells through up-regulation of CIITA (MHC class II transactivator). We then analyzed six gastric cancer cell lines by Northern blot and observed preferential up-regulation of trefoil factor 1, alpha-1-antitrypsin, and galectin 4 and down-regulation of cytidine deaminase in cells prone to peritoneal dissemination. Genes highly correlated with invasion or peritoneal dissemination of gastric cancer, such as E-cadherin or integrin beta4, were down-regulated in both of the derivative cell lines analyzed in this study. This is the first demonstration of global gene expression analysis of gastric cancer cells with different metastatic potentials, and these results provide a new insight in the study of human gastric cancer metastasis. (+info)Invasion activating caveolin-1 mutation in human scirrhous breast cancers. (4/66)
We looked for mutations in the caveolin-1 gene, encoding a critical molecule for membrane signaling to cell growth, in 92 primary human breast cancers, and we report here the identification of a mutation in caveolin-1 at codon 132 (P132L) in 16% of cases. The mutation-positive cases were mostly invasive scirrhous carcinomas. In cell lines expressing the same mutant of caveolin-1, we observed that the mutant Caveolin-1 expression seemed to induce cellular transformation and activation of mitogen-activated protein kinase-signaling pathway and to promote invasion-ability as well as altered actin networks in the cells. These results provide, for the first time, genetic evidence that a functioning Caveolin-1 mutation may have a role in the malignant progression of human breast cancer. (+info)Intestinal perforation due to metastasis of breast carcinoma, with special reference to chemotherapy: a case report. (5/66)
We report a case of small-bowel perforation due to metastatic carcinoma of the breast during chemotherapy. Partial resection of the small intestine and primary anastomosis were performed. Although the patient made a good recovery from panperitonitis, she died of the disease on the 55th postoperative day. Since perforation during chemotherapy results in an extremely poor prognosis, special caution during chemotherapy is needed for patients with possible gastrointestinal involvement with tumor. (+info)A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. (6/66)
Scirrhous carcinoma of the stomach is characterized by rapid growth with a vast fibrous stroma, high invasiveness, and substantially a poor prognosis. Little is known of the molecular pathogenesis of this disease. Members of the emerging family of the CCN gene (for connective tissue growth factor, cysteine-rich 61, nephroblastoma overexpressed) encode cysteine-rich secreted proteins with roles in human fibrotic disorders and cancer progression. Using targeted differential displays, we identified a novel variant of the CCN family member WISP1 (Wnt-induced secreted protein 1), named WISP1v, as overexpressed in scirrhous gastric carcinomas. Predicted protein of the WISP1v completely lacks a module of Von Willebrand type C that is thought to participate in protein complex formation. Ectopic expression revealed WISP1v to be a secreted oncoprotein inducing a striking cellular transformation and rapid piling-up growth. It is noteworthy that WISP1v transfectants enhanced the invasive phenotype of co-cultured gastric carcinoma cells, while wild-type WISP1 had no such potential. These findings suggest that CCN protein WISP1v is involved in the aggressive progression of scirrhous gastric carcinoma. (+info)Detection method and breast carcinoma histology. (7/66)
BACKGROUND: The association between method of detection and breast carcinoma histopathology has not been assessed adequately in a population-based setting. METHODS: Among women who were included in a population-based, case-control study of breast cancer, patients who were newly diagnosed with invasive breast carcinoma were identified from Wisconsin's statewide tumor registry. Only women age > or = 50 years were analyzed, because screening by mammography was not recommended before age 50 years at the time of the study. The breast tumors among these women (n = 2341 tumors) included the following histopathologies: lobular carcinoma (n = 206 tumors); ductal carcinoma, not otherwise specified (n = 1920 tumors); papillary carcinoma (n = 15 tumors); medullary carcinoma (n = 36 tumors); mucinous adenocarcinoma (n = 56 tumors); tubular adenocarcinoma (n = 41 tumors); invasive comedocarcinoma (n = 24 tumors); scirrhous adenocarcinoma (n = 15 tumors); and mixed ductal/lobular carcinoma (n = 28 tumors). RESULTS: Overall, women reported that 41% of tumors were detected by mammography, 48% of tumors were self detected, and 11% of tumors were detected by clinical breast examination (CBE). Detection by mammography was significantly more likely for women who had tubular carcinoma (83%; P < 0.001) and invasive comedocarcinoma (67%; P = 0.23) compared with women who had ductal carcinoma (40%). Mammography was significantly less likely to detect medullary carcinoma (17%) than ductal carcinoma (40%; P = 0.01). Lobular carcinoma was the only histopathology that, compared with ductal carcinoma, was detected significantly more often by CBE than by self detection. Mammography detected lobular carcinoma (42%) as frequently as ductal carcinoma (40%). However, the use of postmenopausal hormones may have modified these detection patterns: Among current users, mammography discovered a greater percentage of ductal carcinomas (51%) and fewer lobular carcinomas (36%) than nonusers. CONCLUSIONS: Among women age > or = 50 years, breast cancer detection by mammography, self detection, and CBE varied according to tumor histopathology. (+info)Scirrhous gastric carcinoma with mediastinal invasion in a dog. (8/66)
An 8-year-old male Rottweiler was presented for recurrent episodes of dysphagia and vomiting with chronic weight loss. Radiography revealed a mediastinal mass in the heart base region. Necropsy revealed a firm, white mediastinal mass extending along the distal esophagus, through the diaphragm, to the gastric cardia, leftward to the convex visceral aspect of the fundus, and rightward along the lesser curvature of the stomach to the pyloric antrum. The gastric lymph node was enlarged and the omentum contained several nodules. Histologically, deep fundic mucosa contained pleomorphic, vacuolated cells with intracytoplasmic mucin, which was hyaluronidase resistant. Neoplastic cells were cytokeratin positive and vimentin negative. Transmural invasion was evidenced by the presence of cytokeratin-positive cells between smooth muscle bundles of the gastric wall. The mediastinal mass was composed of clusters of neoplastic cells in a stroma of dense and loose connective tissue. Neoplastic cells were also within blood and lymphatic vessels, tracheobronchial and gastric lymph nodes, and around peripheral nerves. This carcinoma most likely arose from the gastric fundus and extended to the cardia, from where it advanced proximally to the mediastinum as well as further rightward along the lesser curvature, demonstrating an anatomic continuity suggestive of a direct invasion. Metastasis, evidenced by the presence of lymphatic, blood, and perineural tumor emboli, also occurred. (+info)
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Hypo dieta purină
International Classification of Diseases for Oncology
Adenocarcinoma, NOS M8140/6 Adenocarcinoma, metastatic, NOS M8141/3 Scirrhous adenocarcinoma Scirrhous carcinoma Carcinoma with ... Basophil adenocarcinoma Mucoid cell adenocarcinoma M8310/0 Clear cell adenoma M8310/3 Clear cell adenocarcinoma, NOS Clear cell ... Parietal cell adenocarcinoma M8215/3 Adenocarcinoma of anal glands (C21.1) Adenocarcinoma of anal ducts M8220/0 Adenomatous ... NOS M8210/3 Adenocarcinoma in adenomatous polyp Adenocarcinoma in tubular adenoma Carcinoma in adenomatous polyp Adenocarcinoma ...
List of MeSH codes (C04)
... adenocarcinoma, scirrhous MeSH C04.557.470.200.025.095.410 - linitis plastica MeSH C04.557.470.200.025.105 - adenocarcinoma, ... adenocarcinoma MeSH C04.557.470.200.025.030 - adenocarcinoma, bronchiolo-alveolar MeSH C04.557.470.200.025.045 - adenocarcinoma ... adenocarcinoma, mucinous MeSH C04.557.470.200.025.085 - adenocarcinoma, papillary MeSH C04.557.470.200.025.085.225 - carcinoma ... adenocarcinoma, sebaceous MeSH C04.557.470.550.175 - adenoma, sweat gland MeSH C04.557.470.550.175.125 - acrospiroma, eccrine ...
Renal cell carcinoma
It is considered an adenocarcinoma. There are two subtypes: sporadic (that is, non-hereditary) and hereditary. Both such ... Koenig divided the tumors into scirrhous, steatomatous, fungoid and medullary forms. Following the classification of the tumour ...
Prostate cancer
The most common form of acinar adenocarcinoma, in turn, is "adenocarcinoma, not otherwise specified", also termed conventional ... Adams J (1853). "The case of scirrhous of the prostate gland with corresponding affliction of the lymphatic glands in the ... "Prostatic Adenocarcinoma". Stanford University School of Medicine. Retrieved 2019-10-30. Rao SR, Snaith AE, Marino D, Cheng X, ... The LNCaP cancer cell line was established from a human lymph node metastatic lesion of prostatic adenocarcinoma. PC-3 and DU- ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
HuGE Navigator|HuGE Literature Finder|PHGKB
Serine threonine kinase 11/liver kinase B1 mutation in sporadic scirrhous-type gastric cancer cells. Carcinogenesis 2020 Mar . ... Mutation Variants and Co-Mutations as Genomic Modifiers of Response to Afatinib in HER2-Mutant Lung Adenocarcinoma. The ... and BRAF/RAS-wild-type colorectal adenocarcinomas is effective in detecting tumors with actionable oncogenic gene fusions. ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
IMSEAR at SEARO: Search
1 Adenocarcinoma, Scirrhous --patho.... *. next > IMSEAR is the collaborative product of Health Literature, Library and ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
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No article was found for Adenocarcinoma, Scirrhous and STK11[original query]. File Formats Help:. How do I view different file ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
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No article was found for Adenocarcinoma, Scirrhous and MTOR[original query]. File Formats Help:. How do I view different file ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
Cholangiocarcinoma Imaging: Practice Essentials, Computed Tomography, Magnetic Resonance Imaging
8] The diffuse sclerosing or scirrhous types are densely fibrotic and have annular long strictures. Compared with other tumors ... The most common cause of malignant biliary obstruction is pancreatic adenocarcinoma. Gallbladder carcinoma is 9 times more ...
Value Set Concept Details
Scirrhous adenocarcinoma (morphologic abnormality) Code System Concept Status. Published. Code System Preferred Concept Name. ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
Cholangiocarcinoma Imaging: Practice Essentials, Computed Tomography, Magnetic Resonance Imaging
8] The diffuse sclerosing or scirrhous types are densely fibrotic and have annular long strictures. Compared with other tumors ... The most common cause of malignant biliary obstruction is pancreatic adenocarcinoma. Gallbladder carcinoma is 9 times more ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
Pancreatic Cancer Imaging: Practice Essentials, Radiography, Computed Tomography
In clinical practice, pancreatic cancer is synonymous with pancreatic ductal adenocarcinoma, which constitutes 90% of all ... pancreatic adenocarcinoma, as shown in the images below, is the second most common cause of death from cancer. ... Margins of the low-attenuating mass usually are poorly defined and correspond to a hypovascular scirrhous tumor. Pancreatic ... Radiologic characteristics of pancreatic adenocarcinoma are shown in the images below.). Scan from axial multisection CT in a ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
Code System Concept
... scirrhous (morphologic abnormality) {128646008 , SNOMED-CT } Hepatocellular carcinoma, spindle cell variant (morphologic ... Adenoma AND/OR adenocarcinoma (morphologic abnormality) {115215004 , SNOMED-CT } Download Relationships Other Relationships No ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
Cholangiocarcinoma Imaging: Practice Essentials, Computed Tomography, Magnetic Resonance Imaging
8] The diffuse sclerosing or scirrhous types are densely fibrotic and have annular long strictures. Compared with other tumors ... The most common cause of malignant biliary obstruction is pancreatic adenocarcinoma. Gallbladder carcinoma is 9 times more ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
About 5% of IDCs enhance slowly and/or less strongly, particularly if they are highly scirrhous. [32] ... Detection of occult primary breast carcinoma in the presence of carcinoma in axillary lymph node or metastatic adenocarcinoma ...
Cholangiocarcinoma Imaging: Practice Essentials, Computed Tomography, Magnetic Resonance Imaging
8] The diffuse sclerosing or scirrhous types are densely fibrotic and have annular long strictures. Compared with other tumors ... The most common cause of malignant biliary obstruction is pancreatic adenocarcinoma. Gallbladder carcinoma is 9 times more ...
Adenocarcinoma, Scirrhous | Profiles RNS
Scirrhous" by people in this website by year, and whether "Adenocarcinoma, Scirrhous" was a major or minor topic of these ... "Adenocarcinoma, Scirrhous" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Adenocarcinoma, Scirrhous" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Adenocarcinoma, Scirrhous". ...
Multicentric Reticulohistiocytosis: Practice Essentials, Pathophysiology, Etiology
HuGE Navigator|Genopedia|PHGKB
International Classification of Diseases for Oncology - Wikipedia
Adenocarcinoma, NOS M8140/6 Adenocarcinoma, metastatic, NOS M8141/3 Scirrhous adenocarcinoma Scirrhous carcinoma Carcinoma with ... Basophil adenocarcinoma Mucoid cell adenocarcinoma M8310/0 Clear cell adenoma M8310/3 Clear cell adenocarcinoma, NOS Clear cell ... Parietal cell adenocarcinoma M8215/3 Adenocarcinoma of anal glands (C21.1) Adenocarcinoma of anal ducts M8220/0 Adenomatous ... NOS M8210/3 Adenocarcinoma in adenomatous polyp Adenocarcinoma in tubular adenoma Carcinoma in adenomatous polyp Adenocarcinoma ...
Code System Concept
IMSEAR at SEARO: Search
amhe.org
Typically, when the tumor arises from the cells of the proximal renal tubular epithelium, it is considered as an Adenocarcinoma ... Koenig divided the tumor into classification with different forms of scirrhous, fungoid and medullary. ... ", "renal adenocarcinoma" or simply renal or kidney cancer. Its by far the most common kind of kidney cancer found in adults. ...
Vice-President - Research output - Keio University
Matsumoto, M., Chiba, K., Toyama, Y., Takeshita, K., Seichi, A., Nakamura, K., Arimizu, J., Fujibayashi, S., Hirabayashi, S., Hirano, T., Iwasaki, M., Kaneoka, K., Kawaguchi, Y., Ijiri, K., Maeda, T., Matsuyama, Y., Mikami, Y., Murakami, H., Nagashima, H., Nagata, K., & 18 othersNakahara, S., Nohara, Y., Oka, S., Sakamoto, K., Saruhashi, Y., Sasao, Y., Shimizu, K., Taguchi, T., Takahashi, M., Tanaka, Y., Tani, T., Tokuhashi, Y., Uchida, K., Yamamoto, K., Yamazaki, M., Yokoyama, T., Yoshida, M. & Nishiwaki, Y., 2008 Apr, In: Spine. 33, 9, p. 1034-1041 8 p.. Research output: Contribution to journal › Article › peer-review ...
Bio2Vec
Gastric Cancer Workup: Approach Considerations, Imaging Studies, Histologic Findings
Adenocarcinoma of the stomach constitutes 90-95% of all gastric malignancies. The second most common gastric malignancies are ... In general, researchers consider gastric cancers ulcerative, polypoid, scirrhous (ie, diffuse linitis plastica), superficial ... Meta-analysis of D1 versus D2 gastrectomy for gastric adenocarcinoma. Ann Surg. 2011 May. 253(5):900-11. [QxMD MEDLINE Link]. ... Adenocarcinoma of the stomach is subclassified according to histologic description as follows: tubular, papillary, mucinous, or ...
Medical Exhibits, Demonstrative Aids, Illustrations and Models
breast, cross, section, scirrhous, carcinoma, fibroadenoma, cyst, adenocarcinoma,. suspensory, ligament, fat, tissue, lymph, ... A hard plastic cross-section of a breast showing the following pathologies: infiltrating scirrhous carcinoma, fibroadenoma, ... cysts, and an adenocarcinoma. Model also includes structures such as suspensory ligaments, fat tissue, lymph nodes, muscles and ...
September | 2019 | PPAR Signaling
References 1. Souza RF, Spechler SJ: Concepts in the prevention of adenocarcinoma of the distal esophagus and proximal stomach ... Recent results of therapy for scirrhous gastric cancer. Surg see more Today 2009, 39: 290-4.PubMedCrossRef 3. Chen CY, Wu ... and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma. Orotidine 5′-phosphate ... cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma ( ...
OBM Genetics | Molecular Mechanisms of Feline Cancers
Feline mammary adenocarcinoma (FMA) have been observed as a model for human triple-negative breast cancer (TNBC), a type of ... though there have been anaplastic and scirrhous carcinoma observed as well [90]. Feline mammary cancers (and carcinomas in ... Wiese DA, Thaiwong T, Yuzbasiyan-Gurkan V, Kiupel M. Feline mammary-basal-like adenocarcinomas: A potential model for human ... Feline mammary cancers are most often seen as tubular, papillary, or solid adenocarcinoma, ...
Procollagen type I C-peptide (PIP) detection
Table: Common Neoplasms Often Treated with Radiation Therapy - Merck Veterinary Manual
Cancer aromatase | Article about Cancer aromatase by The Free Dictionary
A tumor may be dense (scirrhous) or soft (medullary or cerebriform), depending on the degree of the stromas development. ... On this basis, cylindrical carcinoma (also called glandular cancer or adenocarcinoma) and squamous cell carcinoma are ... during pregnancy to prevent miscarriage developed vaginal adenocarcinomas as young women. Aflatoxins are natural mold ...
Cholangiocarcinoma Imaging: Practice Essentials, Computed Tomography, Magnetic Resonance Imaging
Adenocarcinoma, Bronchiolo-Alveolar | Profiles RNS
Adenocarcinoma, Follicular. *Adenocarcinoma, Mucinous. *Adenocarcinoma, Papillary. *Adenocarcinoma, Scirrhous. *Adenocarcinoma ... "Adenocarcinoma, Bronchiolo-Alveolar" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ... This graph shows the total number of publications written about "Adenocarcinoma, Bronchiolo-Alveolar" by people in this website ... Below are the most recent publications written about "Adenocarcinoma, Bronchiolo-Alveolar" by people in Profiles. ...
Breast imaging-reporting and data system (BI-RADS) assessment category 2 | Radiology Reference Article | Radiopaedia.org
Carcinoma ex mixed tumor | definition of carcinoma ex mixed tumor by Medical dictionary
Called also alveolar carcinoma or adenocarcinoma and bronchiolar, bronchioloalveolar, or bronchoalveolar adenocarcinoma. ... scirrhous carcinoma carcinoma with a hard structure owing to the formation of dense connective tissue in the stroma. Called ... mucinous carcinoma an adenocarcinoma that produces significant amounts of mucin.. nasopharyngeal carcinoma a malignant tumor ... Four primary subtypes are distinguished: adenocarcinoma of the lung, large cell carcinoma, small cell carcinoma, and squamous ...
Carcinoma signet ring cell. Medical search
alveolar adenocarcinoma ( bronchioalveolar adenocarcinoma ) ( bronchiolar adenocarcinoma ) ( bronchioloalveolar adenocarcinoma ... The histological type was commonly scirrhous and infiltrative. The survival of patients with signet ring cell carcinoma was ... Signet-ring cell adenocarcinoma - This rare and aggressive type of adenocarcinoma usually forms in the stomach or colon, but it ... Some studies suggest that the papillary adenocarcinoma and the signet ring cell adenocarcinoma variants are more likely to ... ...
Cholangiocarcinoma Imaging: Practice Essentials, Computed Tomography, Magnetic Resonance Imaging
Magnetic Resonance Mammography: Practice Essentials, Technique, Preparation
Cholangiocarcinoma Imaging: Practice Essentials, Computed Tomography, Magnetic Resonance Imaging
Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review | World Journal of Surgical...
We herein reported a race case of gastric adenocarcinoma with metastasis to the right breast. Breast biopsy showed invasive ... The diagnosis of metastatic poorly differentiated signet-ring cell adenocarcinoma of the right breast identical to gastric ... Biopsy demonstrated low-grade gastric adenocarcinoma with signet-ring features. In immunohistochemistry, mammary malignant ... Cases of primary gastric adenocarcinoma with metastasis to the breast are extremely rare. Till now, only 38 cases have been ...
The strengths and weaknesses of gross and histopathological evaluation in hepatocellular carcinoma: a brief review | Surgical...
What Is Papillary Urothelial Carcinoma High Grade - HealthySkinWorld.com
About 2% to 7% are squamous cell carcinomas, and 2% are adenocarcinomas. Adenocarcinomas may be of urachal origin or nonurachal ... Renal parenchyma often develops a high-grade scirrhous mass formation and turns to a malignant tumor. In urothelial carcinoma, ... The sarcomatoid areas may merge with foci of urothelial carcinoma , squamous cell carcinoma, adenocarcinoma or small-cell ... Those include nested variant, micropapillary, lymphoepithelioma-like, sarcomatoid, small cell carcinoma, and adenocarcinoma. ...
Carcinoma7
- M8043/3 Small cell carcinoma, fusiform cell M8044/3 Small cell carcinoma, intermediate cell M8045/3 Combined small cell carcinoma Mixed small cell carcinoma Combined small cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell carcinoma (C34. (wikipedia.org)
- Renal cell carcinoma (RCC) carries different names like "hypernephroma", "renal adenocarcinoma" or simply renal or kidney cancer. (amhe.org)
- A hard plastic cross-section of a breast showing the following pathologies: infiltrating scirrhous carcinoma, fibroadenoma, cysts, and an adenocarcinoma. (medicalexhibits.com)
- Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib. (uchicago.edu)
- bronchioalveolar carcinoma ( bronchiolar carcinoma ) ( bronchioloalveolar carcinoma ) ( bronchoalveolar carcinoma ) a variant type of adenocarcinoma of the lung , with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. (thefreedictionary.com)
- Called also alveolar carcinoma or adenocarcinoma and bronchiolar , bronchioloalveolar , or bronchoalveolar adenocarcinoma . (thefreedictionary.com)
- adenocarcinoma of the lung , large cell carcinoma , small cell carcinoma , and squamous cell carcinoma . (thefreedictionary.com)
Carcinomas2
- About 2% to 7% are squamous cell carcinomas, and 2% are adenocarcinomas. (healthyskinworld.com)
- The vast majority of breast carcinomas are adenocarcinomas (ductal or lobular). (cancersearch.org)
Diffuse1
- [ 8 ] The diffuse sclerosing or scirrhous types are densely fibrotic and have annular long strictures. (medscape.com)
Mucinous1
- Adenocarcinoma of the stomach is subclassified according to histologic description as follows: tubular, papillary, mucinous, or signet-ring cells, and undifferentiated lesions. (medscape.com)
Malignant1
- The most common cause of malignant biliary obstruction is pancreatic adenocarcinoma . (medscape.com)
Tumor1
- Koenig divided the tumor into classification with different forms of scirrhous, fungoid and medullary. (amhe.org)
Gastric malignancies1
- Adenocarcinoma of the stomach constitutes 90-95% of all gastric malignancies. (medscape.com)
Stomach1
- Procollagen type I C-peptide (PIP) has been extensively referenced in correlation studies between collagen levels and certain health disorders such as bone disease, alcoholic liver disease, liver cirrhosis, and scirrhous (Borrmann type IV) adenocarcinoma of the stomach. (takarabio.com)
Glandular1
- An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. (ouhsc.edu)
Type1
- Adenocarcinomas may be of urachal origin or nonurachal origin the latter type is generally thought to arise from metaplasia of chronically irritated transitional epithelium. (healthyskinworld.com)
Form1
- There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues. (ouhsc.edu)
Year1
- This graph shows the total number of publications written about "Adenocarcinoma, Scirrhous" by people in this website by year, and whether "Adenocarcinoma, Scirrhous" was a major or minor topic of these publications. (jefferson.edu)
Publications1
- Below are the most recent publications written about "Adenocarcinoma, Scirrhous" by people in Profiles. (jefferson.edu)
Hepatocellular carcinoma and cholangiocarcinoma1
- The value of gadobenate dimeglumine-enhanced hepatobiliary-phase MR imaging for the differentiation of scirrhous hepatocellular carcinoma and cholangiocarcinoma with or without hepatocellular carcinoma. (espacio-seram.com)
Carcinoma1
- A hard plastic cross-section of a breast showing the following pathologies: infiltrating scirrhous carcinoma, fibroadenoma, cysts, and an adenocarcinoma. (medicalexhibits.com)
Diffuse3
- Scirrhous type gastric cancer is characterized by diffuse infiltration of poorly differentiated adenocarcinoma cells and poor prognosis. (nih.gov)
- [ 8 ] The diffuse sclerosing or scirrhous types are densely fibrotic and have annular long strictures. (medscape.com)
- Subtle endoscopic manifestations of diffuse signet cell gastric adenocarcinoma in patients with CDH1 mutations. (amedeo.com)
Gastric cancer2
Pancreatic1
- The most common cause of malignant biliary obstruction is pancreatic adenocarcinoma . (medscape.com)
MeSH1
- Adenocarcinoma, Scirrhous" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
Differentiation2
- 3. Integrated clinicopathological and immunohistochemical analysis of gastric adenocarcinoma with hepatoid differentiation: an exploration of histogenesis, molecular characteristics, and prognostic markers. (nih.gov)
- 5. [ gastric adenocarcinoma with enteroblastic differentiation and elevated serum alpha fetoprotein]. (nih.gov)
Instability1
- The purpose of this study was to elucidate the relationship between intratumoral regional heterogeneity in DNA ploidy and chromosomal instability (CIN) in primary gastric adenocarcinomas. (aacrjournals.org)
Prognosis1
- 1. Both the serum AFP test and AFP/ gpc3 /SALL4 immunohistochemistry are beneficial for predicting the prognosis of gastric adenocarcinoma. (nih.gov)
Tissues2
- Furthermore, we investigated the expression levels of miR‑200c by in situ hybridization, along with the expression of ZEB1 and E-cadherin by immunohistochemistry, in 97 gastric adenocarcinoma tissues. (nih.gov)
- There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues. (uams.edu)
Signet1
- Adenocarcinoma of the stomach is subclassified according to histologic description as follows: tubular, papillary, mucinous, or signet-ring cells, and undifferentiated lesions. (medscape.com)
Cells1
- An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. (uams.edu)
Hard1
- An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (uams.edu)