A malignant epithelial tumor with a glandular organization.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Tumors or cancer of the LUNG.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Tumors or cancer of the ESOPHAGUS.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
Tumors or cancer of the STOMACH.
That part of the STOMACH close to the opening from ESOPHAGUS into the stomach (cardiac orifice), the ESOPHAGOGASTRIC JUNCTION. The cardia is so named because of its closeness to the HEART. Cardia is characterized by the lack of acid-forming cells (GASTRIC PARIETAL CELLS).
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the COLON.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A cell line derived from cultured tumor cells.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Tumors or cancer of the INTESTINES.
Tumors or cancer of the PROSTATE.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Tumors or cancer of the DUODENUM.
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
Tumors or cancer of the CECUM.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
A condition in which there is a change of one adult cell type to another similar adult cell type.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Tumors or cancer of the RECTUM.
A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).
A benign epithelial tumor with a glandular organization.
The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.
DNA present in neoplastic tissue.
Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Experimental transplantation of neoplasms in laboratory animals for research purposes.
The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Tumors or cancer of the PARANASAL SINUSES.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Surgical removal of the pancreas. (Dorland, 28th ed)
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Tumors or cancer of the UTERINE CERVIX.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Tumors or cancer of the APPENDIX.
Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Tumors or cancer of the gallbladder.
Tumors or cancer of the SIGMOID COLON.
Excision of part (partial) or all (total) of the esophagus. (Dorland, 28th ed)
Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissue. There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Sialylated Lewis blood group carbohydrate antigen found in many adenocarcinomas of the digestive tract, especially pancreatic tumors.
Tumors or cancer of the UTERUS.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Elements of limited time intervals, contributing to particular results or situations.
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Transplantation between animals of different species.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
RNA present in neoplastic tissue.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Antimetabolites that are useful in cancer chemotherapy.
Endoscopic examination, therapy or surgery of the esophagus.
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
A pair of anal glands or sacs, located on either side of the ANUS, that produce and store a dark, foul-smelling fluid in carnivorous animals such as MEPHITIDAE and DOGS. The expelled fluid is used as a defensive repellent (in skunks) or a material to mark territory (in dogs).
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Antibodies produced by a single clone of cells.
Metastases in which the tissue of origin is unknown.
Inhaling and exhaling the smoke of burning TOBACCO.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
Biochemical identification of mutational changes in a nucleotide sequence.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.
Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.
A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Excision of the uterus.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
An embryonic structure originating from the ALLANTOIS. It is a canal connecting the fetal URINARY BLADDER and the UMBILICUS. It is normally converted into a fibrous cord postnatally. When the canal fails to be filled and remains open (patent urachus), urine leaks through the umbilicus.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Tumors or cancer of the LIVER.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.
Neoplasms composed of more than one type of neoplastic tissue.
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
Tumors or cancer of the NOSE.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
Tumors or cancer of the SALIVARY GLANDS.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
Tumors or cancer of the BILE DUCTS.
A BETARETROVIRUS that causes pulmonary adenomatosis in sheep (PULMONARY ADENOMATOSIS, OVINE).
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Tumors or cancer of the DIGESTIVE SYSTEM.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Tumors or cancer of the VAGINA.
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Retrograde flow of duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the STOMACH.

Borrmann's type IV gastric cancer: clinicopathologic analysis. (1/66)

OBJECTIVE: To determine whether there is a specific pattern of clinicopathological features that could distinguish Borrmann's type IV gastric cancer from other types of gastric cancer. DESIGN: A retrospective study of patients with advanced gastric cancer treated between 1985 and 1995. SETTING: The Department of Surgery, Sendai National Hospital, a 716-bed teaching hospital. PATIENTS: The clinicopathologic features of 88 patients with Borrmann's type IV carcinoma of the stomach were reviewed from the database of gastric cancer. The results were compared with those of 309 patients with other types of gastric carcinoma. MAIN OUTCOME MEASURES: Gender, age, tumour size, depth of invasion, histologic type, cancer-stromal relationship, histologic growth pattern, nodal involvement, lymphatic and vascular invasion, type of operation, cause of death and 5-year survival. RESULTS: Women were afflicted as commonly as men in the Borrmann's type IV group. These patients tended to be younger and to have larger tumours involving the entire stomach than patients with other types of cancer. Histologic type was commonly diffuse and scirrhous, and serosal invasion was prominent with infiltrative growth. Nodal involvement and lymphatic invasion were more common in patients with Borrmann's type IV than in those with other types of gastric cancer. The disease was advanced in most instances and a total gastrectomy was performed in 55% of the patients. The survival rate of patients with Borrmann's type IV tumour was lower than for patients with other types of gastric cancer (p < 0.005, log-rank test). CONCLUSIONS: In Borrmann's type IV gastric cancer, early detection and curative resection are crucial to extend the patient's survival. Aggressive postoperative chemotherapy is recommended when a noncurative resection is performed.  (+info)

Scirrhous cancer of the stomach which survived for more than five years after neoadjuvant chemotherapy with UFT (uracil and tegafur) and cisplatin. (2/66)

A 68-year-old man was diagnosed as having a scirrhous cancer of the stomach. Carcinomatous peritonitis was suspected on abdominal CT examination. Three courses of uracil and tegafur (UFT)/cisplatin (CDDP) chemotherapy were administered. The primary foci were reduced in size, then total gastrectomy was performed. Histological findings revealed a poorly differentiated adenocarcinoma with scirrhous invasion into the subserosa. Histological efficacy of the chemotherapy was judged to be grade 2. The patient has been alive without disease for more than five years after total gastrectomy. Neoadjuvant chemotherapy with UFT and CDDP may have contributed to the favorable clinical outcome in this patient.  (+info)

Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes. (3/66)

Scirrhous gastric cancer is often accompanied by metastasis to the peritoneum and/or lymph nodes, resulting in the highest mortality rate among gastric cancers. Mechanisms involved in gastric cancer metastasis are not fully clarified because metastasis involves multiple steps and requires the accumulation of altered expression of many different genes. Thus, independent analysis of any single gene would be insufficient to understand all of the aspects of gastric cancer metastasis. In this study, we performed global analysis on differential gene expression of a scirrhous gastric cancer cell line (OCUM-2M) and its derivative sublines with high potential for metastasis to the peritoneal cavity (OCUM-2MD3) and lymph nodes (OCUM-2MLN) in a nude mice model. By applying a high-density oligonucleotide array method, expression of approximately 6800 genes was analyzed, and selected genes were confirmed by the Northern blot method. In our observations in OCUM-2MD3 cells, 12 genes were up-regulated, and 20 genes were down-regulated. In OCUM-2MLN cells, five genes were up-regulated, and five genes were down-regulated. The analysis revealed two functional gene clusters with altered expression: (a) down-regulation of a cluster of squamous cell differentiation marker genes such as small proline-rich proteins [SPRRs (SPRR1A, SPRR1B, and SPRR2A], annexin A1, epithelial membrane protein 1, cellular retinoic acid-binding protein 2, and mesothelin in OCUM-2MD3 cells; and (b) up-regulation of a cluster of antigen-presenting genes such as MHC class II (DP, DR, and DM) and invariant chain (II) in OCUM-2MLN cells through up-regulation of CIITA (MHC class II transactivator). We then analyzed six gastric cancer cell lines by Northern blot and observed preferential up-regulation of trefoil factor 1, alpha-1-antitrypsin, and galectin 4 and down-regulation of cytidine deaminase in cells prone to peritoneal dissemination. Genes highly correlated with invasion or peritoneal dissemination of gastric cancer, such as E-cadherin or integrin beta4, were down-regulated in both of the derivative cell lines analyzed in this study. This is the first demonstration of global gene expression analysis of gastric cancer cells with different metastatic potentials, and these results provide a new insight in the study of human gastric cancer metastasis.  (+info)

Invasion activating caveolin-1 mutation in human scirrhous breast cancers. (4/66)

We looked for mutations in the caveolin-1 gene, encoding a critical molecule for membrane signaling to cell growth, in 92 primary human breast cancers, and we report here the identification of a mutation in caveolin-1 at codon 132 (P132L) in 16% of cases. The mutation-positive cases were mostly invasive scirrhous carcinomas. In cell lines expressing the same mutant of caveolin-1, we observed that the mutant Caveolin-1 expression seemed to induce cellular transformation and activation of mitogen-activated protein kinase-signaling pathway and to promote invasion-ability as well as altered actin networks in the cells. These results provide, for the first time, genetic evidence that a functioning Caveolin-1 mutation may have a role in the malignant progression of human breast cancer.  (+info)

Intestinal perforation due to metastasis of breast carcinoma, with special reference to chemotherapy: a case report. (5/66)

We report a case of small-bowel perforation due to metastatic carcinoma of the breast during chemotherapy. Partial resection of the small intestine and primary anastomosis were performed. Although the patient made a good recovery from panperitonitis, she died of the disease on the 55th postoperative day. Since perforation during chemotherapy results in an extremely poor prognosis, special caution during chemotherapy is needed for patients with possible gastrointestinal involvement with tumor.  (+info)

A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. (6/66)

Scirrhous carcinoma of the stomach is characterized by rapid growth with a vast fibrous stroma, high invasiveness, and substantially a poor prognosis. Little is known of the molecular pathogenesis of this disease. Members of the emerging family of the CCN gene (for connective tissue growth factor, cysteine-rich 61, nephroblastoma overexpressed) encode cysteine-rich secreted proteins with roles in human fibrotic disorders and cancer progression. Using targeted differential displays, we identified a novel variant of the CCN family member WISP1 (Wnt-induced secreted protein 1), named WISP1v, as overexpressed in scirrhous gastric carcinomas. Predicted protein of the WISP1v completely lacks a module of Von Willebrand type C that is thought to participate in protein complex formation. Ectopic expression revealed WISP1v to be a secreted oncoprotein inducing a striking cellular transformation and rapid piling-up growth. It is noteworthy that WISP1v transfectants enhanced the invasive phenotype of co-cultured gastric carcinoma cells, while wild-type WISP1 had no such potential. These findings suggest that CCN protein WISP1v is involved in the aggressive progression of scirrhous gastric carcinoma.  (+info)

Detection method and breast carcinoma histology. (7/66)

BACKGROUND: The association between method of detection and breast carcinoma histopathology has not been assessed adequately in a population-based setting. METHODS: Among women who were included in a population-based, case-control study of breast cancer, patients who were newly diagnosed with invasive breast carcinoma were identified from Wisconsin's statewide tumor registry. Only women age > or = 50 years were analyzed, because screening by mammography was not recommended before age 50 years at the time of the study. The breast tumors among these women (n = 2341 tumors) included the following histopathologies: lobular carcinoma (n = 206 tumors); ductal carcinoma, not otherwise specified (n = 1920 tumors); papillary carcinoma (n = 15 tumors); medullary carcinoma (n = 36 tumors); mucinous adenocarcinoma (n = 56 tumors); tubular adenocarcinoma (n = 41 tumors); invasive comedocarcinoma (n = 24 tumors); scirrhous adenocarcinoma (n = 15 tumors); and mixed ductal/lobular carcinoma (n = 28 tumors). RESULTS: Overall, women reported that 41% of tumors were detected by mammography, 48% of tumors were self detected, and 11% of tumors were detected by clinical breast examination (CBE). Detection by mammography was significantly more likely for women who had tubular carcinoma (83%; P < 0.001) and invasive comedocarcinoma (67%; P = 0.23) compared with women who had ductal carcinoma (40%). Mammography was significantly less likely to detect medullary carcinoma (17%) than ductal carcinoma (40%; P = 0.01). Lobular carcinoma was the only histopathology that, compared with ductal carcinoma, was detected significantly more often by CBE than by self detection. Mammography detected lobular carcinoma (42%) as frequently as ductal carcinoma (40%). However, the use of postmenopausal hormones may have modified these detection patterns: Among current users, mammography discovered a greater percentage of ductal carcinomas (51%) and fewer lobular carcinomas (36%) than nonusers. CONCLUSIONS: Among women age > or = 50 years, breast cancer detection by mammography, self detection, and CBE varied according to tumor histopathology.  (+info)

Scirrhous gastric carcinoma with mediastinal invasion in a dog. (8/66)

An 8-year-old male Rottweiler was presented for recurrent episodes of dysphagia and vomiting with chronic weight loss. Radiography revealed a mediastinal mass in the heart base region. Necropsy revealed a firm, white mediastinal mass extending along the distal esophagus, through the diaphragm, to the gastric cardia, leftward to the convex visceral aspect of the fundus, and rightward along the lesser curvature of the stomach to the pyloric antrum. The gastric lymph node was enlarged and the omentum contained several nodules. Histologically, deep fundic mucosa contained pleomorphic, vacuolated cells with intracytoplasmic mucin, which was hyaluronidase resistant. Neoplastic cells were cytokeratin positive and vimentin negative. Transmural invasion was evidenced by the presence of cytokeratin-positive cells between smooth muscle bundles of the gastric wall. The mediastinal mass was composed of clusters of neoplastic cells in a stroma of dense and loose connective tissue. Neoplastic cells were also within blood and lymphatic vessels, tracheobronchial and gastric lymph nodes, and around peripheral nerves. This carcinoma most likely arose from the gastric fundus and extended to the cardia, from where it advanced proximally to the mediastinum as well as further rightward along the lesser curvature, demonstrating an anatomic continuity suggestive of a direct invasion. Metastasis, evidenced by the presence of lymphatic, blood, and perineural tumor emboli, also occurred.  (+info)

Transforming growth factor β1 (TGF-β1) is a potent growth inhibitor for many cell types, including tumor cells. We recently have reported the establishment and characterization of two human gastric scirrhous carcinoma cell lines, HSC-39 and HSC-43. Here we examined the effect of TGF-β1 on the growth of these lines as compared to five other human gastric adenocarcinoma cell lines. Proliferation of HSC-39 and HSC-43 cells was strongly inhibited by TGF-β1, whereas the other gastric adenocarcinoma cell lines were unresponsive to TGF-β1. Both HSC-39 and HSC-43 cells gradually lost viability following exposure to TGF-β1. This response was dose dependent up to 4 ng/ml. When TGF-β1 was removed, the cells failed to exhibit regrowth, indicating an irreversible growth-inhibitory effect of this agent, leading to cell death. DNA fragments were observed consisting of multimers of approximately 180 base pairs 24 h after TGF-β1 treatment. The chromatin condensation of each cell line was confirmed by ...
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This phase II trial investigated the efficacy and tolerability of dovitinib in adults with advanced scirrhous gastric cancer who have disease progression
Supporting: 1, Mentioning: 16 - Neoadjuvant Chemotherapy in Scirrhous Cancer of the Stomach Using Uracil and Tegafur and Cisplatin. - Shoji SUGA, Hiroaki IWASE, Masaaki SHIMADA, Yuji NISHIO, Toru ICHIHARA, Shu ICHIHARA, Kazuo KUSUGAMI, Hidehiko SAITO
It seemed that the state of tyrosine phosphorylation was not altered by the expression of the caveolin-1 mutant. We next used a variety of phospho-specific antibodies (12) that have been generated against the activated forms of well-known signal transducers. Fig. 4d ⇓ shows that both intracellular MAPKs and p38-MAPK 4 were constitutively activated in the caveolin-1 mutant clones. On the other hand, the status of phosphorylation of AKT was not changed, although v-Src-transformed cells (SR3Y1) showed increased phosphorylation of AKT. Again, these experiments demonstrated the capacity for the mutant to drive cell transformation. These observations are compatible with previous reports showing that alteration of caveolin-1 function could be involved in the cellular transformation as a dominant negative effect of caveolin-1.. The mutation-positive cases of breast cancer were mostly involved in the pathologically invasive types such as scirrhous carcinomas (18) . Hence, we suspected that the ...
hypo symptoms - MedHelps hypo symptoms Center for Information, Symptoms, Resources, Treatments and Tools for hypo symptoms. Find hypo symptoms information, treatments for hypo symptoms and hypo symptoms symptoms.
TY - JOUR. T1 - Clinical Significance of Conversion Surgery for Gastric Cancer with Peritoneal Dissemination. T2 - A Retrospective Study. AU - Arigami, Takaaki. AU - Matsushita, Daisuke. AU - Okubo, Keishi. AU - Sasaki, Ken. AU - Noda, Masahiro. AU - Kita, Yoshiaki. AU - Mori, Shinichiro. AU - Kurahara, Hiroshi. AU - Yanagita, Shigehiro. AU - Uenosono, Yoshikazu. AU - Ishigami, Sumiya. AU - Ohtsuka, Takao. AU - Natsugoe, Shoji. N1 - Publisher Copyright: © 2020 S. Karger AG, Basel.. PY - 2020/11/1. Y1 - 2020/11/1. N2 - Objective: Although chemotherapy has been clinically recommended as the initial treatment for patients with peritoneal dissemination of gastric cancer, poor prognosis has been noted among the same patients. However, the prognostic significance of conversion surgery after chemotherapy remains unclear. The present study therefore aimed to assess the clinical impact of conversion surgery among patients with peritoneal dissemination of gastric cancer. Methods: A total of 93 patients ...
The German bank looks a better bet for the private equity firm than Friends Provident. Hypo is cheap and has a promising loan flow. But it s not ideal. Flowers is getting only 25%, and Hypo s discredited bosses will stay. Flowers may be feeling the pressure to do a deal.
Thank you for your replies. The time I feel worse is in the morning meals and snack and in the evening and I feel better overall but am exhausted from
I am 19 years old and I have SPD. I am hypo sensitive and I like to chew on things a lot. That is how I regulate myself. I just wanted to let you know
hyper/hypo - MedHelps hyper/hypo Center for Information, Symptoms, Resources, Treatments and Tools for hyper/hypo. Find hyper/hypo information, treatments for hyper/hypo and hyper/hypo symptoms.
TABLE-US-00001 TABLE 1 Table 1. Results summary of time spent over 180 mg/dL (TO180[min]) and number of hypoglycemic events (HYPO# [--]) for ten subjects in all nine experiments. Subject # Exp# 1 Exp# 2 Exp# 3 Exp# 4 Exp# 5 Exp# 6 Exp# 7 Exp# 8 Exp# 9 1 TO180 1107 1074 970 938 1006 947 919 1156 1018 Hypo# 0 0 0 0 0 0 0 0 0 2 TO180 993 587 412 221 487 189 156 1115 540 Hypo# 0 0 0 0 0 0 0 0 0 3 TO180 657 486 471 456 455 434 417 730 470 Hypo# 0 0 0 0 0 0 0 0 0 4 TO180 1140 587 480 466 57 0 0 1147 155 Hypo# 0 0 0 0 0 0 0 0 0 5 TO180 708 635 538 485 208 171 160 889 405 Hypo# 0 0 0 0 0 0 1 0 0 6 TO180 1149 766 596 520 635 417 259 1150 711 Hypo# 0 0 0 0 0 0 0 0 0 7 TO180 413 428 309 291 73 56 58 739 195 Hypo# 0 0 0 0 0 0 0 0 0 8 TO180 457 855 585 523 612 475 349 1098 743 Hypo# 0 0 0 0 0 0 0 0 0 9 TO180 153 385 319 269 265 181 120 477 324 Hypo# 0 0 0 0 0 0 0 0 0 10 TO180 492 596 444 421 233 119 88 885 423 Hypo# 0 0 0 0 0 0 0 0 0 As noted, Exp#8 (Experiment # 8, open loop with 40%) meal uncertainty, ...
All long- and intermediate-acting insulins contain crystals and they settle to the bottom of the vial. They must be re-suspended before drawing up and injecting the insulin. Research has shown that the vial must be rolled or tipped 20 times to achieve a satisfactory mixture. This also applies to insulin in pens. Failure to do this can result in unexpected hypos because there will be less crystals in the insulin and it is the crystals that slow down the action of the insulin ...
W Polsce, Colostrumhypo.pl ma miejsce 1 172 974 w rankingu, z szacunkową ilością < 300 odwiedzających w miesiącu. Kliknij, żeby zobaczyć inne dane o tej witrynie.
GI ProHealths ProZymes are a SCD legal stomach enzyme which can be used by people on the SCD Diet. ProZymes stomach enzymes are hypo allergenic and made for people with sensitive GI systems.
Table 3: Pharmacokinetic parameters of paclitaxel (PAC) and docetaxel (DOC) in plasma and ascitic fluid after an i.p. administration of drugs in crEL or PS-80 to nontumor rats [18 ...
In recent years, increasing research has focused on the relationship between cytokines and tumorigenesis. It has been suggested that cytokines may be a new therapeutic option for tumors (16-20). In our experiments, we demonstrated that IFN-λ1 inhibited the growth of gastric carcinoma cells in a concentration-dependent manner. These data suggest that IFN-λ1 may be a potential antitumor agent for the treatment of gastric cancer.. Impaired apoptotic induction and dysregulated cell cycle progression are important factors in cancer development. Accordingly, inhibition of cell cycle regulation is particularly useful in the treatment of cancer. In our in vitro study, we demonstrated the apoptosis-inducing effects of IFN-λ1 in gastric carcinoma cells using PI cell cycle analysis, Annexin V and PI staining as well as activated caspase-3. Our study showed that IFN-λ1 induced G1 phase arrest and apoptosis in the gastric carcinoma cells.. Experimental evidence suggests that apoptosis can be mediated by ...
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If you dont have, or know, anyone with diabetes, you may be asking what are hypos? If you do, youre almost certainly up to speed with what they mean. A hypo is the common term for low blood sugar, and symptoms include feeling faint, dizzy, hungry, trembly, anxious or having blurred vision. If its not treated and gets worse, it can even cause loss of consciousness and it can occasionally be fatal . The consequences can be severe, especially if youre driving or operating machinery at the time. Having hypos can reduce your quality of life and your confidence, and thats why this week is the first ever Hypoglycaemia Awareness Week, launched by the NHS .
Im thinking of getting a puppy for my daughter. Shes 2 years old but Im not sure what type of dog to get. I want something that wont get too big and Im thinking maybe hypo allergenic. Any suggestions on types of dogs, where to buy from, and pricing?
The Cancer Genome Atlas (TCGA) dataset for gastric cancer has shown that the gastric cancer populations with nonsynonymous KRAS, BRAF, or MEK1 mutations were relatively small (28 of 289, 24 of 289, and 7 of 289, respectively), and MEK1 Q56P or S72G mutations have not been identified in the TCGA dataset. In this study, we identified MEK1 mutations in poorly differentiated gastric cancer cell lines that were hypersensitive to MEK inhibitors and showed that these mutations have transformational abilities and that the growth of the cancer cells is dependent on these mutations. Specifically, the MEK1 S72Q mutation in the Okajima cell line is a novel activating mutation, whereas the MEK1 Q56P mutation in the OCUM-1 cell line has been previously reported by Choi and colleagues (17). In addition, a MEK1 Q56P mutation was identified in a clinical sample of a poorly differentiated gastric cancer; to the best of our knowledge, this is the first study in which a clinical sample of a MEK1 Q56P-mutated ...
Yeah. I did yes. So you know. You know, you pick up things, but there we are, because you always remember you go to casualty especially with somebody with diabetes who is in a hypo and one of the sisters here used to say, Go and get a Mars Bar for them. And you know it is only simple things like that but you remember, or a sugary drink. You know, to try to get them to drink it, milk is another thing, which you try and do. Marie biscuits. So, you know you tend to prepare yourself. Afterwards I was prepared for it, you know, I always had something like that. And make sure that you, I make sure that I eat fairly regularly at times, you know within a certain times. Not exactly heavy meals. But may, I have a little something to eat before I got to bed in the night because when you are at rest sometimes you dont want to go want to go hypo in the middle of the night, and you have got to experience being hypo as well. Because its really, ah it is something different. It is like walking on eggshells. ...
TS-5000Z味觉分析系统(电子舌)的开发历经数年,其研发团队从上世纪80年代开始研究味觉传感器,从初的交互敏感型响应,到现在可以实现对酸、甜、苦、咸等基本味道专一选择性的响应,其间发表论文数百篇,以下仅列举近年来的与大家分享: ...
I have made 2 batches of of plain hypo fixer for my toning process that has gotten milky/cloudy after fixing approximately 50 8x10 prints. I am using some old Zone VI hypo (anhydrous I assume since it is 673 grams for making a gallon). To that hypo, I add 120 grams of sodium sulfite. It is hot in the south and my fixing bath was 77 degrees, if that has anything to do with it. In my printing process, I use fixer 24 at 4 minutes, then wash and dry the prints for toning later. When I tone,
Buddy, If we are indeed supposed to be solving problems and not causing them, which I agree is true, then I suggest you read your own posts before you send them. The post in questions *sounded* very judgemental, to me at least and obviously some others here. To tell someone to just to count carbs better is like a slap in the face - It is your fault, just do it right next time and you will be fine. Hello? We all do our best and sometimes it is not enough. Diabetes can be so variable, who knows what causes a hypo? Some days I eat the same things, do the same things, and one day it is high, one day it is low, another day it will be perfect. I am trying to figure out why and, after many years, am very happy to find what is usually a safe place to talk about the ups and downs. So you might consider the wide variety of ways a post can be interpreted before you post. And if you keep getting flack, maybe that is something to consider. :) Janine getting out her Kevlar ,Yes Greg I do go low. Dont get ...
¿Tienes un nivel elevado de ácido úrico? ¿Te duelen las articulaciones y se inflaman, como por ejemplo los dedos? Para reducir el ácido úrico, sería adecuado que, además de seguir las pautas médicas, mejoraras tu dieta con estos consejos. Te contamos cómo pueden ayudarte algunas verduras.
Adenocarcinoma, NOS M8140/6 Adenocarcinoma, metastatic, NOS M8141/3 Scirrhous adenocarcinoma Scirrhous carcinoma Carcinoma with ... Basophil adenocarcinoma Mucoid cell adenocarcinoma M8310/0 Clear cell adenoma M8310/3 Clear cell adenocarcinoma, NOS Clear cell ... Parietal cell adenocarcinoma M8215/3 Adenocarcinoma of anal glands (C21.1) Adenocarcinoma of anal ducts M8220/0 Adenomatous ... NOS M8210/3 Adenocarcinoma in adenomatous polyp Adenocarcinoma in tubular adenoma Carcinoma in adenomatous polyp Adenocarcinoma ...
... adenocarcinoma, scirrhous MeSH C04.557.470. - linitis plastica MeSH C04.557.470.200.025.105 - adenocarcinoma, ... adenocarcinoma MeSH C04.557.470.200.025.030 - adenocarcinoma, bronchiolo-alveolar MeSH C04.557.470.200.025.045 - adenocarcinoma ... adenocarcinoma, mucinous MeSH C04.557.470.200.025.085 - adenocarcinoma, papillary MeSH C04.557.470. - carcinoma ... adenocarcinoma, sebaceous MeSH C04.557.470.550.175 - adenoma, sweat gland MeSH C04.557.470.550.175.125 - acrospiroma, eccrine ...
It is considered an adenocarcinoma. There are two subtypes: sporadic (that is, non-hereditary) and hereditary. Both such ... Koenig divided the tumors into scirrhous, steatomatous, fungoid and medullary forms. Following the classification of the tumour ...
The most common form of acinar adenocarcinoma, in turn, is "adenocarcinoma, not otherwise specified", also termed conventional ... Adams J (1853). "The case of scirrhous of the prostate gland with corresponding affliction of the lymphatic glands in the ... "Prostatic Adenocarcinoma". Stanford University School of Medicine. Retrieved 2019-10-30. Rao SR, Snaith AE, Marino D, Cheng X, ... The LNCaP cancer cell line was established from a human lymph node metastatic lesion of prostatic adenocarcinoma. PC-3 and DU- ...
Micrograph of prostate adenocarcinoma, acinar type, the most common type of prostate cancer. Needle biopsy, H&E stain ... Adams J (1853). "The case of scirrhous of the prostate gland with corresponding affliction of the lymphatic glands in the ... The LNCaP cancer cell line was established from a human lymph node metastatic lesion of prostatic adenocarcinoma. PC-3 and DU- ... The region of prostate gland where the adenocarcinoma is most common is the peripheral zone. Initially, small clumps of cancer ...
Adenocarcinoma. Stomach Neoplasms. Neoplasms by Site. Stomach Diseases. Linitis Plastica. Adenocarcinoma, Scirrhous. Neoplasms ... Adenocarcinoma, Scirrhous Linitis Plastica Stomach Neoplasms Stomach Diseases Neoplasms by Site Neoplasms Drug: TKI258 Phase 2 ... A Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Advanced Scirrhous Gastric Carcinoma Patients. The ... Advanced scirrhous gastric carcinoma. Gastric Cancer. Second-line or third-line treatment. VEGF. FGFR. Neoplasms. Gastric ...
MeSH-major] Adenocarcinoma, Scirrhous / drug therapy. Adenocarcinoma, Scirrhous / enzymology. Dihydrouracil Dehydrogenase (NADP ... MeSH-major] Adenocarcinoma, Scirrhous / drug therapy. Adenocarcinoma, Scirrhous / pathology. Antineoplastic Combined ... MeSH-minor] Adenocarcinoma, Scirrhous / metabolism. Adenocarcinoma, Scirrhous / pathology. Animals. Catalytic Domain / ... Core needle biopsy demonstrated scirrhous carcinoma.. *[MeSH-major] Adenocarcinoma, Scirrhous / drug therapy. Antibodies, ...
Adenocarcinoma, Scirrhous / genetics* * Adenocarcinoma, Scirrhous / pathology * Colonic Neoplasms / genetics * DNA Probes * DNA ... Frequent Amplification of the C-Met Gene in Scirrhous Type Stomach Cancer Biochem Biophys Res Commun. 1992 Nov 30;189(1):227-32 ... Among them, c-met amplification was detected in 5 gastric cancer cell lines, derived from scirrhous gastric carcinoma and in 5 ... 38%) of 13 scirrhous gastric carcinoma tissues. Furthermore, patients of gastric carcinoma with c-met amplification showed ...
... adenocarcinoma cells with intermediate nuclei; (T) well-differentiated and less aggressive (low grade) adenocarcinoma cells ... N) Acinar and tubular, high grade; (O) acinar and cyst papillary, intermediate grade; (P) tubular and scirrhous, low grade. (Q- ... K-M) Different growth patterns of mammary adenocarcinoma in different PinX1+/- mice. (N-P) Different growth patterns and tumor ... adenocarcinoma cells with huge nuclei; (S) intermediately differentiated and aggressive (intermediate grade) ...
adenocarcinoma (majority of cases) mucinous (colloid) adenocarcinoma signet ring adenocarcinoma scirrhous tumors neuroendocrine ... have a poorer prognosis than pure adenocarcinoma variants. References:. * Saclarides TJ, Szeluga D, Staren ED: Neuroendocrine ... Wolmark N, Rockette H, Wickerham DL, et al.: Adjuvant therapy of Dukes A, B, and C adenocarcinoma of the colon with portal- ... Wolmark N, Rockette H, Wickerham DL, et al.: Adjuvant therapy of Dukes A, B, and C adenocarcinoma of the colon with portal- ...
Disease Scirrhous Adenocarcinoma For-Profit: $551.00 Non-Profit: $468.35 Qty:. Add to Cart ...
Signet ring adenocarcinoma.. *Scirrhous tumors.. *Neuroendocrine.[1 ] Tumors with neuroendocrine differentiation typically have ... Willett C, Tepper JE, Cohen A, et al.: Local failure following curative resection of colonic adenocarcinoma. Int J Radiat Oncol ... Panettiere FJ, Goodman PJ, Costanzi JJ, et al.: Adjuvant therapy in large bowel adenocarcinoma: long-term results of a ... Sun XF, Carstensen JM, Zhang H, et al.: Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma. ...
Adenocarcinoma, Scirrhous / physiopathology * Animals * Anti-Infective Agents * Antiviral Agents * Ascorbic Acid / physiology* ...
Breast cancer (scirrhous, intraductal, unspecified types) [35] * Cervical cancer. * Colon cancer (adenocarcinoma) ...
Gastric adenocarcinoma, lymphoma. 2. Ménétriers disease. 2-4. Scirrhous carcinoma, lymphoma. 3. Varices, anisakiasis. ...
Moreover, the K-sam gene is amplified preferentially in poorly differentiated adenocarcinoma of scirrhous carcinoma. K-sam ... Among them, those most commonly implicated in both well-differentiated adenocarcinoma and poorly differentiated adenocarcinoma ... LOH on chromosome 18q (DCC locus) and LOH of the bcl-2 gene also are common events of well-differentiated adenocarcinoma. LOH ... Conversely, the development of poorly differentiated adenocarcinoma, in addition to changes in p53 and c-met genes, requires ...
Especially in these situations, immunohistochemistry may also help in distinguishing between HCC and other adenocarcinomas84. ... scirrhous hepatocellular carcinoma88; steatohepatic HCC89; HCC with lymphoid stroma, clear-cell variant of HCC and sarcomatous ... fibrolamellar versus scirrhous hepatocellular carcinoma. Histopathology. 2017;71:217-26. [ Links ] ...
In clinical practice, pancreatic cancer is synonymous with pancreatic ductal adenocarcinoma, which constitutes 90% of all ... pancreatic adenocarcinoma, as shown in the images below, is the second most common cause of death from cancer. ... The margins of the low-attenuating mass usually are poorly defined and correspond to a hypovascular scirrhous tumor. Pancreatic ... encoded search term (Pancreatic Adenocarcinoma Imaging) and Pancreatic Adenocarcinoma Imaging What to Read Next on Medscape. ...
Scirrhous adenocarcinoma is thought to arise near the pylorus and spread proximally.15 These tumors can eventually demonstrate ... Primary scirrhous adenocarcinoma of the stomach spreads predominantly in the submucosa and muscularis propria. This type of ... Scirrhous carcinoma of the pyloric channel and distal antrum. AJR Am J Roentgenol.1980;134:669-673. ... Scirrhous carcinoma of the stomach: Radiologic and endoscopic diagnosis. Radiology. 1990;175: 151-154. ...
Adenocarcinoma *Scirrhous Carcinoma *Ulcerating Carcinoma *Metastases Principles of Operative Procedures *I *II Postgastrectomy ...
Scirrhous Gastric Carcinoma: Endoscopy versus Upper Gastrointestinal RadiographyRadiology May 1, 2004 231:421-426. http://rad. ... Gastric biopsy : Mucinous adenocarcinoma grade2/3. Peritoneal biopsy: Metastatic mucinous adenocarcinoma. Gastric cancer, ... Diagnosed as esophageal adenocarcinoma outside for evaluation.. A CT scan of chest with IV contrast and CT of the abdomen and ... Mucinous adenocarcinomas of the stomach and colon can demonstrate a sand-like calcific pattern. Larger more discrete focal ...
CUB-domain-containing protein 1 (CDCP1) was shown to promote metastasis in scirrhous and lung adenocarcinomas as well as in ...
CUB-domain-containing protein 1 (CDCP1) was shown to promote metastasis in scirrhous and lung adenocarcinomas as well as in ...
Gastric Cancer, Adenocarcinoma, Scirrhous, Cisplatin, Chemotherapy, Metastasis. 1. Introduction. Gastric cancer is the third ... 7. Otsuji, E., Kuriu, Y. and Okamoto, K. (2004) Outcome of Surgical Treatment for Patients with Scirrhous Carcinoma of the ... 10. Kinugasa, S., Abe, S. and Tachibana, M. (1997) Surgically Curable and Incurable Scirrhous Carcinomas of the Stomach. ... 9. Yoshikawa, T., Tsuburaya, A. and Kobayashi, O. (2001) Should Scirrhous Gastric Carcinoma Be Treated Surgically Clinical ...
Here we examined the effect of TGF-β1 on the growth of these lines as compared to five other human gastric adenocarcinoma cell ... Our results suggest that TGF-β1 induces cell death in human gastric scirrhous carcinoma cells in vitro which is mediated by ... Proliferation of HSC-39 and HSC-43 cells was strongly inhibited by TGF-β1, whereas the other gastric adenocarcinoma cell lines ... We recently have reported the establishment and characterization of two human gastric scirrhous carcinoma cell lines, HSC-39 ...
3. Adenocarcinoma with productive fibrosis (scirrhous, simplex, NST), 80 (invasive ductal carcinoma of no special type) ... productive fibrosis (scirrhous, simplex, NST) accounts for 80 of breast cancers and presents with macroscopic or microscopic ... especially when a locally advanced scirrhous carcinoma invades dermal lymph vessels in the skin to produce peau dorange and ...
Hepatic resection for hepatic metastases from gastric adenocarcinoma. J Gastr Cancer. (2013) 13:86-92. doi: 10.5230/jgc.2013.13 ... Recent results of therapy for scirrhous gastric cancer. Surg Today. (2009) 39:290-4. doi: 10.1007/s00595-008-3860-1 ... Patterns of initial recurrence in completely resected gastric adenocarcinoma. Ann Surg. (2004) 240:808-16. doi: 10.1097/01.sla. ... Analysis of hepatic resection of metastasis originating from gastric adenocarcinoma. J Gastrointest Surg. (2002) 6:682-9. doi: ...
A tumor may be dense (scirrhous) or soft (medullary or cerebriform), depending on the degree of the stromas development. ... On this basis, cylindrical carcinoma (also called glandular cancer or adenocarcinoma) and squamous cell carcinoma are ... during pregnancy to prevent miscarriage developed vaginal adenocarcinomas as young women. Aflatoxins are natural mold ...
2007) CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma. Mol Cell Biol 27:7649- ... reported strong enhancement of migration of gastric scirrhous carcinoma cells in vitro by CDCP1 (37) but we saw little effect ... 2008) CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma. Am J Pathol 172:1729- ... The Y734F mutant form of CDCP1 also failed to confer anoikis resistance in lung adenocarcinoma cells and failed to promote ...
Adenocarcinoma, Scirrhous. An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense ... Adenocarcinoma, Follicular. An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. ( ... Adenocarcinoma In Situ. A lesion with cytological characteristics associated with invasive adenocarcinoma but the tumor cells ... Adenocarcinoma, Papillary. An adenocarcinoma containing finger-like processes of vascular connective tissue covered by ...
... this patient was a 64-year-old male whose gastric cancer had been diagnosed as a poorly differentiated scirrhous adenocarcinoma ... Signet ring cell histology is an independent predictor of poor prognosis in gastric adenocarcinoma regardless of tumoral ... and the one gastric cancer clinical sample with a MEK1 mutation was a poorly differentiated adenocarcinoma. Choi and colleagues ... these results suggest that gastric cancer with MEK1 mutations might be likely to have a poorly differentiated adenocarcinoma ...
... a human scirrhous gastric cancer cell line. Oncol Rep. 2017;37:2366-2374. ... ROS Inhibition Drives 5-Fu Resistance Dependent on Nrf2 Antioxidative Signaling Pathway in Gastric Adenocarcinoma. *Lu Wen ... ROS Inhibition Drives 5-Fu Resistance Dependent on Nrf2 Antioxidative Signaling Pathway in Gastric Adenocarcinoma. Dig Dis Sci ... a crucial role in the inhibition of 5-Fu-induced apoptosis resistance by removing ROS accumulation in gastric adenocarcinoma, ...
Adenocarcinoma, NOS M8140/6 Adenocarcinoma, metastatic, NOS M8141/3 Scirrhous adenocarcinoma Scirrhous carcinoma Carcinoma with ... Basophil adenocarcinoma Mucoid cell adenocarcinoma M8310/0 Clear cell adenoma M8310/3 Clear cell adenocarcinoma, NOS Clear cell ... Parietal cell adenocarcinoma M8215/3 Adenocarcinoma of anal glands (C21.1) Adenocarcinoma of anal ducts M8220/0 Adenomatous ... NOS M8210/3 Adenocarcinoma in adenomatous polyp Adenocarcinoma in tubular adenoma Carcinoma in adenomatous polyp Adenocarcinoma ...
scirrhous adenocarcinoma 10.2. ERBB2 PGR 14. breast apocrine carcinoma 10.2. ERBB2 PGR ...
  • intestinal: metastasis tardía de adenocarcinoma gástrico em anillo de sello. (berkeleyliberationradio.info)
  • Lymph node metastasis from early gastric cancer: Gastric Adenocarcinoma of the Diffuse Ring Cell Another image of the tumor To enlarge the images in a new window pressure on them. (berkeleyliberationradio.info)
  • ZFAS1 silencing inhibited pancreatic adenocarcinoma metastasis in vitro and in vivo. (biomedcentral.com)
  • Our results demonstrated the promotive effect of ZFAS1 on pancreatic adenocarcinoma metastasis and suggested its potential role as a novel regulator of ROCK2. (biomedcentral.com)
  • Histology was an important risk factor for nodal metastasis, especially in scirrhous carcinoma. (fujita-hu.ac.jp)
  • To predict the scirrhous carcinoma with frequent nodal metastasis, US criteria such as the larger ratio of depth-to-width, boundary echo and attenuation of the back echo was important. (fujita-hu.ac.jp)
  • The prognosis of carcinoma in cases of lymphatic metastasis with a large amount of connective tissue (scirrhous type) was better than that in those with a small amount of connective tissue (non-scirrhous type). (nii.ac.jp)
  • Among them, those most commonly implicated in both well-differentiated adenocarcinoma and poorly differentiated adenocarcinoma are inactivation (mutations and allele loss) of the p53 gene, and activation (abnormal expression and amplification) of the c-met gene. (nih.gov)
  • Conversely, the development of poorly differentiated adenocarcinoma, in addition to changes in p53 and c-met genes, requires reduction or dysfunction of cadherin. (nih.gov)
  • Overexpression of bcl-2 protein is observed in poorly differentiated adenocarcinoma or signet-ring cell carcinoma. (nih.gov)
  • Moreover, the K-sam gene is amplified preferentially in poorly differentiated adenocarcinoma of scirrhous carcinoma. (nih.gov)
  • LOH on chromosome 1p also is relatively common in poorly differentiated adenocarcinoma. (nih.gov)
  • There are some differences in expression of the growth-factor/receptor system between well-differentiated adenocarcinoma and poorly differentiated adenocarcinoma. (nih.gov)
  • Borrmann type 4 was characterized by less differentiation, usually presenting as poorly differentiated adenocarcinoma, and by invasion of the entire wall of the stomach. (scirp.org)
  • Background Isolated cancer cells of non-solid type poorly differentiated adenocarcinoma (por2) or signet-ring cell carcinoma (sig) are frequently seen in scirrhous gastric cancers with a very poor prognosis. (tak-632.net)
  • Keywords: MUC1, Cytoplasmic tail domain, Monoclonal antibody, Scirrhous gastric cancer, Accurate detection Introduction Isolated cancer cells of non-solid type poorly differentiated adenocarcinoma (por2) and signet-ring cell carcinoma (sig) of the stomach in the Japanese Classification of Gastric Carcinoma (JCGC) [1] are frequently seen in scirrhous gastric cancers with a very poor prognosis [2]. (tak-632.net)
  • From time to time low-density masses with low-density lymph nodes are noticed in mucinous adenocarcinoma, because of a lot of the tumor made up of extracellular mucin. (suamaytinhhaiphong.com)
  • Psammomatous calcifications in mucinous adenocarcinoma may also be present. (suamaytinhhaiphong.com)
  • In clinical practice, pancreatic cancer is synonymous with pancreatic ductal adenocarcinoma, which constitutes 90% of all primary malignant tumors arising from the pancreatic gland. (medscape.com)
  • Among them, c-met amplification was detected in 5 gastric cancer cell lines, derived from scirrhous gastric carcinoma and in 5 (38%) of 13 scirrhous gastric carcinoma tissues. (nih.gov)
  • Tamaki R, Kanai-Mori A, Morishige Y, Koike A, Yanagihara K, Amano F. Effects of 5-fluorouracil, adriamycin and irinotecan on HSC-39, a human scirrhous gastric cancer cell line. (springer.com)
  • This study was performed to investigate the inhibitory effects of valproic acid (VPA) on a highly peritoneal-seeding cell line of human scirrhous gastric cancer, OCUM-2MD3, and to explore the mechanism and the potential of VPA. (biomedcentral.com)
  • Video Endoscopic Sequence 10 of Primary and metastatic scirrhous carcinoma of the rectum. (berkeleyliberationradio.info)
  • It is usually a bilateral involvement of ovaries from the metastatic deposit from adenocarcinoma of the stomach. (clinicsinoncology.com)
  • Histologically, ulcerative carcinomas are poorly differentiated adenocarcinomas, which invade deeply into the stomach wall. (medicoapps.org)
  • Histologically, fungating or polypoid carcinomas are well-differentiated adenocarcinomas, commonly papillary type. (medicoapps.org)
  • Colorectal cancers, 98% which are adenocarcinomas, arise in most cases from pre-existing colonic adenomas (neoplastic polyps), which progressively undergo malignant transformation because they accumulate additional mutations 2 (so-known as multi-hit hypothesis). (suamaytinhhaiphong.com)
  • Pancreatic adenocarcinoma (PAAD) is one of the most malignant tumours, with increasing mortality and a 5-year survival rate of less than 8% [ 1 ]. (biomedcentral.com)
  • However, in experienced hands, barium studies still have a higher diagnostic accuracy in identifying relevant pathology and may even be better than endoscopy in detecting scirrhous carcinoma. (radiologykey.com)
  • Therefore, VPA in combination with PTX is expected to be a promising therapy for peritoneal dissemination of scirrhous gastric cancer. (biomedcentral.com)
  • A year-old sister had just been diagnosed with diffuse adenocarcinoma of the stomach with signet-ring cells, having bilateral ovarian involvement at diagnosis and peritoneal carcinomatosis. (berkeleyliberationradio.info)
  • This discussion induces phenotypic … Scirrhous gastric carcinoma (SGC) a subtype of diffuse-type gastric adenocarcinoma includes a inadequate prognosis [34 35 SGC can Clavulanic acid be characterized by fast and diffusive invasion beneath the submucosa solid fibrosis connected with substantial development of fibroblasts and regular peritoneal dissemination. (researchreportone.com)
  • A role for FGFR2 in cancer is supported by the observation that transgenic expression of the FGFR2-specific ligand FGF7 (KGF) leads to prostate hyperplasia and mammary adenocarcinoma ( 22 ). (aacrjournals.org)
  • Comprehensive protein profiling of paired surgical specimens of primary gastric adenocarcinomas and nontumor mucosae derived from Japanese patients was carried out by means of two-dimensional gel electrophoresis (2D-EP) and liquid chromatography-electrospray ionic tandem mass spectrometry (LC-ESI-MS) to establish gastric cancer-specific proteins as putative clinical biomarkers and molecular targets for chemotherapy. (biomedcentral.com)
  • The oncogenic mice carry the polyoma middle T antigen driven by the mouse mammary tumor virus promoter and develop primary adenocarcinomas of the breast. (aacrjournals.org)
  • O carcinoma gástrico é uma neoplasia com distribuição mundial, estando as fases de um adenocarcinoma gástrico, do tipo difuso, com células em anel desinete. (berkeleyliberationradio.info)
  • In a section of the posterior wall of the fundus, close to the cardia, a small focus of adenocarcinoma was identified. (berkeleyliberationradio.info)
  • Of all the GI malignancies, pancreatic adenocarcinoma , as shown in the images below, is the second most common cause of death from cancer. (medscape.com)
  • Radiologic characteristics of pancreatic adenocarcinoma are seen in the images below. (medscape.com)
  • The mortality and morbidity rates of pancreatic adenocarcinoma have been increasing over the past two decades, and an understanding of the mechanisms underlying pancreatic adenocarcinoma progression is urgently needed. (biomedcentral.com)
  • The long non-coding RNA ZFAS1 has been demonstrated to be an oncogene in some cancers, but its function and mechanism in pancreatic adenocarcinoma remain unclear. (biomedcentral.com)
  • The ZFAS1 expression level in pancreatic adenocarcinoma was predicted by bioinformatic analysis, and the expression level of ZFAS1 in pancreatic adenocarcinoma tissue samples and cell lines was further detected by quantitative real-time PCR and in situ hybridization. (biomedcentral.com)
  • The functions of ZFAS1 in pancreatic adenocarcinoma in vitro and in vivo were investigated by further bioinformatic analysis. (biomedcentral.com)
  • ZFAS1 overexpression in pancreatic adenocarcinoma was predicted and experimentally verified. (biomedcentral.com)
  • Histologically, EGC is a typical glandular adenocarcinoma, usually well-differentiated type. (medicoapps.org)
  • Histologically, ulcer-cancers are adenocarcinomas without any specific features. (medicoapps.org)
  • Gastric adenocarcinomas comprise one of the common types of cancers in Asian countries including Japan. (biomedcentral.com)
  • Gastric adenocarcinomas comprise one of the common types of cancers in Asian countries including Japan, being second only to lung cancer as to the number of deaths it causes. (biomedcentral.com)
  • However, because of its rarity and similar imaging features to those of other liver cancers with fibrosis, it is difficult to diagnose scirrhous HCC using imaging tools ( 8 ). (kowsarpub.com)
  • Conclusions The MAb MUC1-014E is very useful for accurate detection of isolated cancer cells in scirrhous gastric cancers. (tak-632.net)
  • An invasive adenocarcinoma of the accessory parotid gland: a rare example developing from a low-grade cribriform cystadenocarcinoma? (biomedcentral.com)
  • Our results suggest that TGF-β 1 induces cell death in human gastric scirrhous carcinoma cells in vitro which is mediated by activation of a signal transduction pathway for apoptosis. (aacrjournals.org)
  • Monoclonal antibodies to adenocarcinoma cells, and, in particular, breast carcinoma cells, are produced by a hybridoma formed by fusing mouse lymphocytes and mouse myeloma cells. (google.com)
  • MMP-1 staining in carcinoma cells was significantly higher In scirrhous carcinoma than in other types of carcinoma. (elsevier.com)
  • CANCER (A) Ovarian carcinoma cells and (B) adenocarcinoma of the prostate (orig. (tabers.com)
  • Invasive ductal carcinoma is also called infiltrating ductal carcinoma or ductal adenocarcinoma. (cancer.ca)
  • Scirrhous invasive ductal carcinoma grows faster than the other types. (cancer.ca)
  • Ultrasound examination was performed in 252 patients with invasive ductal carcinoma (91 papillotubular, 54 solid-tubular and 107 scirrhous carcinoma). (fujita-hu.ac.jp)
  • Scirrhous hepatocellular carcinoma (HCC) is a subtype of HCC that is characterized by abundant fibrous stroma admixed with tumor cells. (kowsarpub.com)
  • Therefore, we anticipated that MUC1 CTD takes on an important part in isolated tumor cells in scirrhous gastric malignancies. (tak-632.net)
  • M8043/3 Small cell carcinoma, fusiform cell M8044/3 Small cell carcinoma, intermediate cell M8045/3 Combined small cell carcinoma Mixed small cell carcinoma Combined small cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell carcinoma (C34. (wikipedia.org)
  • The main form of cancer, which accounts for ninety-five percent of prostate cancer, are acinar adenocarcinomas. (treat-simply.com)
  • Results were correlated with tumor growth pattern as defined by the WHO (trabecular, pseudoglandular/acinar, compact, and scirrhous), tumor size, Ki-67 proliferation index, and the modified Edmondson nuclear grade, which has a scale of 1 to 4. (aacrjournals.org)
  • Procollagen Type I C-peptide (PIP) has been extensively referenced in correlation studies between collagen levels and certain health disorders such as bone disease, alcoholic liver disease, liver cirrhosis, and scirrhous (Borrmann type IV) adenocarcinoma of the stomach. (clontech.com)
  • Like classic HCC, scirrhous HCC frequently develops in patients with liver cirrhosis, but there has been no report of synchronous occurrence of classic and scirrhous HCCs. (kowsarpub.com)
  • Here, we report synchronous classic and scirrhous HCCs in a 62-year-old man with early liver cirrhosis who underwent gadoxetic acid-enhanced and diffusion-weighted magnetic resonance imaging. (kowsarpub.com)
  • Scirrhous HCC similar to classic HCC is associated with liver cirrhosis. (kowsarpub.com)
  • These results overall suggest that amplification of the c-met gene might participate in carcinogenesis and progression of stomach cancer, especially scirrhous type stomach carcinoma. (nih.gov)
  • LOH on chromosomes 1q and 7q may be involved in the progression of well-differentiated adenocarcinoma. (nih.gov)
  • Importantly, selective inhibition of this enzyme reduces adenocarcinoma formation and cancer progression in preclinical animal models ( 6 -8 ). (aacrjournals.org)
  • Proliferation of HSC-39 and HSC-43 cells was strongly inhibited by TGF-β 1 , whereas the other gastric adenocarcinoma cell lines were unresponsive to TGF-β 1 . (aacrjournals.org)
  • Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma. (mycancergenome.org)
  • In this paper, we present a case of invasive adenocarcinoma of the accessory parotid gland in a young male that exhibited histology suggestive of an association of LGCCA. (biomedcentral.com)
  • Herein, we present a case of invasive adenocarcinoma of the accessory parotid gland in a young male that had left vestiges of LGCCA in its histology. (biomedcentral.com)
  • The World Health Organization classifies gastric carcinoma into four types-(a) papillary, (b) tubular, (c) mucinous, and (d) signet ring cell - and defines mucinous gastric carcinoma as "an adenocarcinoma in which a substantial amount of extracellular mucin (more than 50 percent of the tumor) is retained within the tumor. (diagnosticimaging.com)
  • These are generally scirrhous adenocarcinomas (signet-ring type). (suamaytinhhaiphong.com)
  • The most common form of presentation is adenocarcinoma of the bowel type variant 3,5. (berkeleyliberationradio.info)
  • Biological significance of localized Type IV scirrhous gastric cancer. (berkeleyliberationradio.info)
  • When comparing the US classification and histology, the accuracy rate of US for papillotubular, solid-tubular and scirrhous type was 75%, 78% and 75%, respectively. (fujita-hu.ac.jp)
  • Among them 77 had adenocarcinoma with a large amount of interstitial connective tissue (scirrhous type), and 72 had adenocarcinoma with a comparatively small amount of connective tissue (non-scirrhous type). (nii.ac.jp)
  • The overall survival rate was low among those with scirrhous type (P\u22520.095). (nii.ac.jp)
  • However, in comparing 14 cases (18.1%) of pT2 carcinoma of scirrhous type with 22 cases (32.7%) of pT2 carcinoma of non-scirrhous type, the survival ratio of those of scirrhous type exceeded that of those of non-scirrhous type (P\u22520.045). (nii.ac.jp)
  • This entry was posted in Pim Kinase and tagged Cytoplasmic tail domain , HCl salt , Keywords: MUC1 , Monoclonal antibody , Scirrhous gastric cancer . (tak-632.net)
  • Rarely the stenotic segment is going to be lengthy particularly with scirrhous adenocarcinomas. (suamaytinhhaiphong.com)
  • infiltrative (scirrhous, stenotic) which most often involves the deeper layers of the stomach wall and ulcerative. (clinicsinoncology.com)
  • Perfusion CT of breast carcinoma: arterial perfusion of nonscirrhous carcinoma was higher than that of scirrhous carcinoma. (symptoma.com)
  • An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (bvsalud.org)
  • Among these various subtypes, scirrhous HCC is a rare tumor that shows intense fibrous stroma ( 3 ). (kowsarpub.com)
  • Histologically, it may be an adenocarcinoma or signetring cell carcinoma, extensively infiltrating the stomach wall, but due to marked desmoplasia cancer cells may be difficult to find. (medicoapps.org)
  • The invasive component of the tumor was histologically defined as adenocarcinoma, not otherwise specified (ANOS). (biomedcentral.com)
  • Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). (mycancergenome.org)
  • K-sam amplification in scirrhous carcinoma often occurs independently of c-met gene amplification. (nih.gov)