A malignant epithelial tumor with a glandular organization.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Tumors or cancer of the LUNG.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Tumors or cancer of the ESOPHAGUS.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
Tumors or cancer of the STOMACH.
That part of the STOMACH close to the opening from ESOPHAGUS into the stomach (cardiac orifice), the ESOPHAGOGASTRIC JUNCTION. The cardia is so named because of its closeness to the HEART. Cardia is characterized by the lack of acid-forming cells (GASTRIC PARIETAL CELLS).
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the COLON.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A cell line derived from cultured tumor cells.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Tumors or cancer of the INTESTINES.
Tumors or cancer of the PROSTATE.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Tumors or cancer of the DUODENUM.
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
Tumors or cancer of the CECUM.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
A condition in which there is a change of one adult cell type to another similar adult cell type.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Tumors or cancer of the RECTUM.
A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).
A benign epithelial tumor with a glandular organization.
The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.
DNA present in neoplastic tissue.
Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Experimental transplantation of neoplasms in laboratory animals for research purposes.
The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Tumors or cancer of the PARANASAL SINUSES.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Surgical removal of the pancreas. (Dorland, 28th ed)
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Tumors or cancer of the UTERINE CERVIX.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Tumors or cancer of the APPENDIX.
Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Tumors or cancer of the gallbladder.
Tumors or cancer of the SIGMOID COLON.
Excision of part (partial) or all (total) of the esophagus. (Dorland, 28th ed)
Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissue. There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Sialylated Lewis blood group carbohydrate antigen found in many adenocarcinomas of the digestive tract, especially pancreatic tumors.
Tumors or cancer of the UTERUS.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Elements of limited time intervals, contributing to particular results or situations.
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Transplantation between animals of different species.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
RNA present in neoplastic tissue.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Antimetabolites that are useful in cancer chemotherapy.
Endoscopic examination, therapy or surgery of the esophagus.
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
A pair of anal glands or sacs, located on either side of the ANUS, that produce and store a dark, foul-smelling fluid in carnivorous animals such as MEPHITIDAE and DOGS. The expelled fluid is used as a defensive repellent (in skunks) or a material to mark territory (in dogs).
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Antibodies produced by a single clone of cells.
Metastases in which the tissue of origin is unknown.
Inhaling and exhaling the smoke of burning TOBACCO.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
Biochemical identification of mutational changes in a nucleotide sequence.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.
Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.
A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Excision of the uterus.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
An embryonic structure originating from the ALLANTOIS. It is a canal connecting the fetal URINARY BLADDER and the UMBILICUS. It is normally converted into a fibrous cord postnatally. When the canal fails to be filled and remains open (patent urachus), urine leaks through the umbilicus.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Tumors or cancer of the LIVER.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.
Neoplasms composed of more than one type of neoplastic tissue.
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
Tumors or cancer of the NOSE.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
Tumors or cancer of the SALIVARY GLANDS.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
Tumors or cancer of the BILE DUCTS.
A BETARETROVIRUS that causes pulmonary adenomatosis in sheep (PULMONARY ADENOMATOSIS, OVINE).
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Tumors or cancer of the DIGESTIVE SYSTEM.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Tumors or cancer of the VAGINA.
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Retrograde flow of duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the STOMACH.

A new rapid technique for the fixation of thyroid gland surgical specimens. (1/468)

One of the main diagnostic problems in thyroid pathology is to distinguish between follicular adenoma and follicular carcinoma. Thorough sampling of the nodule's capsule is recommended in order to identify capsular invasion. However, during the hardening of the tissue, by the usual fixatives the capsule shrinks and rolls downwards and sometimes the capsule separates from the remaining tissue. The present work evaluates the use of "Lymph Node Revealing Solution" (LNRS) for the rapid fixation (2h) of different thyroid lesions as compared to that of formalin. Fifty-one unselected consecutive cases of thyroid nodules, which included various benign and malignant lesions, were examined. Each specimen was cut in two equal parts; one was fixed in LNRS, the other in formalin. Fixation in LNRS for 2 hours gave adequate results in sectioning and staining of the tissue, and excellent immunostains. Its advantage over formalin is the conservation of the natural relationship between the capsule and the rest of the tissue, on the same plane, as well as the short time required for the final diagnosis.  (+info)

Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine. (2/468)

The modifying effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a mutagenic by-product in chlorinated water, on the development of glandular stomach cancers were investigated in Wistar rats. A total of 120 males, 6 weeks of age, were divided into six groups. After initiation with 100 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) solution and 5% NaCl diet for 8 weeks, 30 rats each in groups 1-3 were given MX in the drinking water at concentrations of 30, 10, or 0 ppm for the following 57 weeks. Ten animals each in groups 4-6 were administered the MX without prior carcinogen exposure. There were no statistical significant differences in final body weights between the groups. The incidences and multiplicities of adenocarcinomas in the glandular stomachs were significantly higher (P < 0.05) in the initiated 30 ppm MX group than those in the MNNG/NaCl group. The incidences of atypical hyperplasias in the glandular stomachs were also significantly increased (P < 0.05 or 0.01) by the MX treatments. With their multiplicity, the effects were clearly dose dependent. Interestingly, the 30 ppm MX alone itself induced atypical hyperplasias in the pylorus, although the incidences and severity were low. Moreover, MX showed a tendency to enhance the development of intrahepatic cholangiocellular tumors and thyroid follicular cell tumors in the MNNG-treated animals. The results of the present study thus indicate that MX exerts promoting effects when given during the postinitiation phase of two-stage glandular stomach carcinogenesis in rats.  (+info)

DNA copy number changes in thyroid carcinoma. (3/468)

The genetic changes leading to thyroid cancer are poorly characterized. We studied DNA copy number changes by comparative genomic hybridization (CGH) in 69 primary thyroid carcinomas. In papillary carcinoma, DNA copy number changes were rare (3 of 26, 12%). The changes were all gains, and they were associated with old age (P = 0.01) and the presence of cervical lymph node metastases at presentation (P = 0.08). DNA copy number changes were much more frequent in follicular carcinoma (16 of 20, 80%) than in papillary carcinoma (P < 0.0001), and follicular carcinomas had more often deletions (13/20 versus 0/26, P < 0.0001). Loss of chromosome 22 was common in follicular carcinoma (n = 7, 35%), it was more often seen in widely invasive than in minimally invasive follicular carcinoma (54% versus 0%, P = 0.04), and it was associated with old age at presentation (P = 0.01). In three of the four patients with follicular carcinoma who died of cancer, the tumor had loss of chromosome 22. DNA copy number changes were found in 5 (50%) of the 10 medullary carcinomas studied. Four of these five carcinomas had deletions, and in two of them there was deletion of chromosome 22. Eleven (85%) of the thirteen anaplastic carcinomas investigated had DNA copy number changes, of which five had deletions, and one had deletion of chromosome 22. The most common gains in anaplastic carcinoma were in chromosomes 7p (p22-pter, 31%), 8q (q22-qter, 23%), and 9q (q34-qter, 23%). We conclude that DNA copy number changes are frequent in follicular, medullary, and anaplastic thyroid carcinoma but rare in papillary carcinoma when studied by CGH. Loss of chromosome 22 is particularly common in follicular carcinoma, and it is associated with the widely invasive type.  (+info)

Relationship among 201T1 uptake, nuclear DNA content and clinical behavior in metastatic thyroid carcinoma. (4/468)

A prospective study of 201TI uptake was performed to compare 201TI uptake with nuclear deoxyribonucleic acid (DNA) content and clinical behavior of tumors in metastatic thyroid carcinoma and to assess the significance of 201TI uptake in evaluating clinical characteristics of thyroid carcinoma. METHODS: Fifty-six patients with metastases of differentiated thyroid carcinoma had 201TI scintigraphy. Grade of 201TI uptake was semiquantitatively assessed according to tumor-to-background ratio on 2-h late scan. Nuclear DNA content was analyzed within 3 wk of 201TI study by flow cytometry using biopsy material and was classified as diploidy or aneuploidy. Patients were followed up to examine incidence of tumor growth and/or anaplastic transformation. RESULTS: DNA content was diploidy in 48 patients and aneuploidy in 8 patients. 201TI uptake in the DNA-aneuploid group (2.61 +/- 0.29) was significantly higher than that in the DNA-diploid group (1.82 +/- 0.35, P < 0.01 for both groups). Tumor growth was observed in all patients with DNA aneuploidy but in only 5 of 48 patients with DNA diploidy (P < 0.01). Anaplastic transformation was observed in 3 patients in the DNA-aneuploid group but in none of the patients in the DNA-diploid group. CONCLUSION: High 201TI uptake indicates greater incidence of abnormal DNA content with aggressive clinical behavior of metastatic tumors. Thus, 201TI scintigraphy may be useful in characterizing metastatic thyroid carcinoma and in identifying those patients with poorer prognoses.  (+info)

Case-control study of thyroid cancer in Northern Italy: attributable risk. (5/468)

BACKGROUND: The percentage of thyroid cancer cases attributable to specific risk factors can be calculated to focus preventive strategies. The per cent population attributable risks (PAR) for thyroid cancer were estimated in relation to history of benign thyroid diseases, history of radiotherapy, residence in endemic goitre areas and selected indicators of a poor diet, using data from a case-control study conducted between 1986 and 1992 in Northern Italy. METHODS: Cases were 399 histologically confirmed incident thyroid cancers and controls were 617 patients, admitted to hospital for a wide range of acute, non-neoplastic, non-hormone-related diseases. The PAR were computed on the basis of multivariate odds ratios (OR) and on the distribution of risk exposure among cases, assuming they are representative of the general population of cases. RESULTS: A history of benign thyroid disease accounted for 18.9% of cases, radiotherapy for 1.2%, residence for > or =20 years in endemic goitre areas for 2.4% of cases, and their combination for 21.7% of thyroid cancer cases; selected indicators of a poor diet accounted for 40.9% of thyroid cancer cases in this population. The combination of all factors considered explained over 57% of thyroid cancer cases in both sexes. The estimates for thyroid-related conditions were higher in women than men, whereas the opposite was true for dietary indicators. The overall PAR were somewhat higher in people aged > or =45 years (63.8%) than in younger subjects, and for follicular (69.1%) rather than papillary (53.7%) cancers. CONCLUSIONS: Exposure to a few simply identified and potentially modifiable risk factors or indicators (benign thyroid disease, residence in endemic goitre area and a poor diet) explained about 60% of thyroid cancer cases in this Italian population, indicating the theoretical scope for prevention.  (+info)

Reproductive and hormonal risk factors for thyroid cancer in Los Angeles County females. (6/468)

We conducted an individually matched case-control study (292 pairs) of female thyroid cancer patients to examine the role of reproductive history and exogenous hormones in this disease. Radiation treatment to the head or neck [28 cases and 2 controls exposed; odds ratio (OR), 14.0; 95% confidence interval (CI), 3.5-121.3] and certain benign thyroid diseases (including adolescent thyroid enlargement, goiter, and nodules or tumors) were strongly associated with thyroid cancer. Irregular menstruation increased risk (OR, 1.8; 95% CI, 0.9-3.7). Age at menarche and pregnancy history were not related to disease. Women with natural menopause and hysterectomized women without oophorectomy had no increase in risk, but disease risk was elevated in women with bilateral oophorectomy (OR, 6.5; 95% CI, 1.1-38.1). In general, use of oral contraceptives and other exogenous estrogens was not associated with thyroid cancer. However, risk increased with number of pregnancies in women using lactation suppressants (P = 0.03) and decreased with duration of breastfeeding (P = 0.04). These data provide only limited support for the hypothesis that reproductive and hormonal exposures are responsible for the marked excess of thyroid cancer risk in adult females.  (+info)

Non-suppressed thyrotropin and elevated thyroglobulin are independent predictors of recurrence in differentiated thyroid carcinoma. (7/468)

OBJECTIVE: Although in most cases differentiated thyroid carcinoma (DTC) responds to surgery and radioiodine (RaI) therapy, some patients will have recurrence and eventually cancer-related death. However, although various prognostic factors of DTC have been identified (e.g. staging, suppressed thyrotropin), none of the previous studies have assessed simultaneously their role in multivariate analysis. DESIGN AND METHODS: In this retrospective population-based study, we reviewed the clinicopathological data of 254 DTC patients treated in eastern Finland during the years 1976-1995, for clinical characteristics, primary treatment, follow-up and cancer recurrence. Tumor stage was based on pathological tumor-node-metastasis (pTNM) classification, and histopathological specimens were re-evaluated. RESULTS: DTC recurrence occurred in 33 patients (13%). In univariate analyses, the predictors of recurrence were older age (>60 years, P<0.05), follicular tumor type (P<0.01), pTNM classification system (P<0.05) and post-ablative radioiodine uptake outside the neck (P<0.05). Non-suppressed serum thyrotropin (TSH) and elevated serum thyroglobulin (>3 microg/l) measured one year after operation were both related to tumor recurrence (P<0.05 and P<0.001 respectively). In multivariate analysis the independent predictors for recurrence were both elevated thyroglobulin (P<0.001) and non-suppressed TSH (P<0.05) independent of histology, pTNM stage and RaI uptake. Adjusted risk ratio for recurrence of DTC for unsuppressed thyrotropin was 2.3, for elevated thyroglobulin 14.0 and, if both conditions were present, the risk ratio increased to 45.1. CONCLUSION: Our results suggest that both non-suppressed serum TSH and elevated serum thyroglobulin are related to an increased risk of DTC recurrence independent of tumor type and pTNM stage.  (+info)

Expression of cytokeratin 20 in thyroid carcinomas and peripheral blood detected by reverse transcription polymerase chain reaction. (8/468)

We investigated a nested reverse transcriptase polymerase chain reaction (RT-PCR) system to detect CK20 mRNA in thyroid carcinomas, benign thyroid diseases and peripheral blood to improve diagnosis of thyroid carcinoma and to detect disseminated tumour cells. Frozen tissue samples of 46 thyroid carcinomas and 30 benign thyroid diseases (14 multinodular goiters, 14 follicular adenomas, two Hashimoto's thyroiditis) were obtained intraoperatively. Preoperative blood samples were drawn from 31 patients with thyroid cancer, nine patients with benign thyroid disorders and 20 healthy volunteers. Nine out of nine medullary, 9/12 follicular, 7/19 papillary and 2/6 anaplastic carcinomas expressed CK20 transcripts. CK20 mRNA was undetectable in 30 tissue sections of benign thyroid diseases. Circulating tumour cells were found in the blood of 3/8 patients with medullary carcinoma, 2/8 patients with follicular carcinoma, 2/11 patients with papillary carcinoma and 1/4 patients with an anaplastic carcinoma. Nine blood samples of patients with benign thyroid diseases and 20 healthy volunteers tested negative. For the first time CK20 mRNA could be detected in tissue sections of thyroid carcinomas and peripheral blood samples of patients with thyroid cancer. It was not detectable in benign thyroid diseases. Our results therefore strongly suggest that CK20 RT-PCR assays may improve the diagnosis of thyroid carcinoma and is able to detect circulating tumour cells in peripheral blood of thyroid carcinoma patients.  (+info)

Follicular thyroid carcinoma comprises about 25% of all thyroid cancers, and its malignancy generally exceeds that of papillary carcinoma. It spreads relatively early to distant sites such as bone, lungs, and liver by invasion of blood vessels, and regional lymph nodes are usually involved only late. Production of thyroid hormones is almost exclusively associated with the follicular histologic type. In many reported cases the production of thyroid hormones by metastases has been sufficient to cause hyperthyroidism. One of these cases was that of a patient with T3 thyrotoxicosis (1).. We describe here a patient having metastatic follicular thyroid carcinoma with ...
Premenopausal women are at highest risk for papillary and follicular thyroid carcinoma, implicating a role for estrogens in thyroid cancer. The expression of estrogen receptors α and β (ER), the effects of estradiol (E2), selective estrogen receptor modulators (SERMs) 4-hydroxytamoxifen and raloxifene, and ER subtype selective agonists were examined in NPA87 and KAT5 papillary and WRO follicular thyroid carcinoma cell lines. All three thyroid cancer cell lines expressed full-length ERα and ERβ proteins with cytoplasmic localization that was unaffected by E2. ICI 182,780 (Fulvestrant, an ER antagonist), and inhibitors of non-genomic E2-activated MAPK and PI3K signaling blocked E2-induced cell proliferation. SERMs acted in a cell line-specific manner. No E2-induced estrogen response element (ERE)-driven reporter activity was observed in transiently transfected thyroid cancer cells. However, E2 increased transcription of established endogenous E2-target genes, i.e., cathepsin D in WRO and ...
Thalidomide has found new uses as a tumor anti-angiogenesis agent that is capable of diminishing the proliferation of angiogenesis-dependent solid malignancies. Distantly metastatic, unresectable medullary thyroid carcinomas, as well as de-differentiated papillary and follicular thyroid carcinomas, which no longer concentrate radioiodine, have no known effective systemic therapies. We have verified, in the context of a completed phase 2 clinical trial, that thalidomide has significant activity in thyroid carcinomas that are no longer radioiodine avid and are rapidly progressive. This activity has only limited durability of around 7 months and is associated with significant toxicities of sedation, constipation and neuropathy.. REVLIMID® (lenalidomide) is an analog of thalidomide with the chemical name, alpha-(3-aminophthalimido) glutarimide. REVLIMID® is noted to be more potent than thalidomide in inhibiting the production of TNF-alpha. It has more than doubled the inhibition of microvessel ...
We report for the first time a synchronous papillary and follicular thyroid carcinoma in a 12-year-old girl presenting with a large (5 cm diameter) left thyroid nodule, an increased left and right upper pole technetium tracer uptake at scintigraphy and hyperthyroidism. The uptake at the right lobe was explained by the crossing of the left nodule to the right site of the neck at Computed Tomography (CT) scanning. Although thyroid nodules are less common in children than in adults, there is more vigilance required in children because of the higher risk of malignancy. According to literature, about 5% of the thyroid nodules in adults are malignant versus 20-26% in children. The characteristics of 9 other pediatric cases with a differentiated thyroid carcinoma presenting with a toxic nodule, which have been reported during the last 20 years, are summarized. A nodular size of more than 3.5 cm and female predominance was a common finding. The presence of hyperthyroidism in association with a hyperfunctioning
PubMedID: 24185120 | Prognostic Value of p27 in Follicular Thyroid Carcinoma and its Relation to Radioactive Iodine Response: Does it Aid in the Modification of Risk Stratification? | Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry | 10/31/2013
Dr. Keshab Paudel answered: Please see below: Papillary and follicular thyroid cancers are referred to as differentiated thyroid...
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2Department of Endocrinology, Gulhane Military Medical Academy, Ankara-Turkey Brain metastasis is an uncommon and morbid complication of thyroid carcinoma, especially follicular carcinoma. Because of its rarity, management is still debated.. A 64-year-old woman presented with signs of blindness. After ophthalmological and radiological evaluations, A frontobasal mass lesion was detected. The lesion was removed and pathological examination revealed the diagnosis of follicular thyroid carcinoma metastasis. The patient also underwent thyroidectomy, radiotherapy and chemotherapy for follicular carcinoma.. This case shows that the follicular thyroid carcinoma may present with distant metastasis even if it is a rare occurence. Keywords : Follicular thyroid carcinoma, brain metastasis, surgery ...
The report provides comprehensive information on the therapeutics under development for Follicular Thyroid Cancer, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
Results: CD56 expression was significantly higher in papillary thyroid carcinoma (PTC) (conventional and follicular variants) compared to other categories of follicular thyroid lesions, and it was significantly higher in the follicular variant of papillary carcinoma compared to follicular adenomas (FA) and hyperplastic nodules (HN). A bivariate analysis showed that the malignancy in follicular thyroid lesions was significantly associated with higher CD56 expression and older patients age. Both parameters were used to build a logistic regression model and equation for prediction of malignancy in follicular thyroid lesions. On the application of the equation to the studied cases, it was found to conform to their diagnostic nature ...
Factor VIII-related antigen is a recognised marker of endothelial cells. A brief immunocytochemical study of its distribution in follicular carcinoma of the thyroid and its value in the recognition of vascular invasion by this tumour has been carried out. Ten cases of follicular carcinoma of the thyroid were studied. In each strong endothelial staining was found in the majority of vessels in the adjacent normal thyroid. Lymphatic endothelium was negative. In eight of the 10 cases the staining of vessels within the tumour was absent or very weak. Staining was also absent in the majority of vessels completely occluded by tumour, but was present in the endothelium of vessels only partly occluded by tumour. It is concluded that factor VIII-related antigen staining has only limited value in the recognition of vascular invasion in follicular carcinoma. The absence of vascular staining in the tumour leads us to suggest that inhibition of factor VIII production by the tumour could be a possible ...
Post-surgical evaluation and management (NCCN) Return to Follicular Neoplasm Resource Appropriate Guidelines Index: Clinical Practice Guidelines for Thyroid
Follicular thyroid cancer (FTC) is normally a much less common type of differentiated thyroid cancer. common type of differentiated thyroid cancers and spreads via haematogenous dissemination with faraway metastases taking place in 10 to 15 percent of sufferers most commonly situated in bone tissue or lungs. Based on the American thyroid association suggestions, treatment of FTC faraway metastases needs 131I so long as iodine avidity is normally conserved. We survey the initial case of an individual presenting a intensifying non resectable and iodine nonavid hepatic metastasis of FTC treated by radioembolization using hepatic selective inner rays therapy (SIRT). Case display A 69-year-old guy offered follicular thyroid cancers (T4N1M1) originally treated by total thyroidectomy and ablation of 1 bone tissue metastasis (cervical) accompanied by a first dosage of radioactive 131-iodine (131I). During 14 years follow-up, the individual provided many recurrences in bone fragments frequently, lungs, ...
In this retrospective multicenter cohort study, we evaluated the prognostic value of WHO-2017 and independent prognostic factors associated with DFS and DSS in 318 patients with FTC. After adapting WHO-2017, 79.6% and 20.4% patients who were classified as having MI-FTC based on WHO-2004 were categorized as having MI-FTC and EA-FTC, respectively. Using WHO-2017, patients with EA- and WI-FTC had significantly poorer DFS than those with MI-FTC, and there was significant difference in the DFS curves among groups. Comparing WHO-2004 and WHO-2017, the PVE and C-index were increased from 5.4% to 7.1% and 0.391 to 0.649, respectively. However, there was no significant difference in DSS between patients with MI- and EA-FTC. Only patients with WI-FTC had significantly poorer DSS than those with MI-FTC. The PVE value was 2.6% using both WHO-2004 and WHO-2017. Independent risk factors associated with shorter DFS were older age, gross ETE, EA- and WI-FTC, and presence of LN metastasis. In terms of DSS, older ...
The PAX 8 gene has some association with follicular thyroid tumors. PAX8/PPARy rearrangement account for 30-40% of conventional type follicular carcinomas[14] and less than 5% of oncocytic carcinomas (aka Hurthle-Cell Neoplasms).[15] Tumors expressing the PAX8/PPARy are usually present in at a young age, small in size, present in a solid/nested growth pattern and frequently involve vascular invasion. It has been observed that PAX8/PPAR y-positive tumors rarely express RAS mutations in combination. This suggests that follicular carcinomas develop in two distinct pathways either with PAX8/PPAR y or RAS. Some whole-genome sequencing studies have shown that PAX8 also targets BRCA1 (carcinogenesis), MAPK pathways (thyroid malignancies), and Ccnb1 and Ccnb2 (cell-cycle processes). PAX8 is shown to be involved in tumor cell proliferation and differentiation, signal transduction, apoptosis, cell polarity and transport, cell motility and adhesion.[8]. Expression of PAX8 is increased in neoplastic renal ...
I have read with great interest the recent systematic review by Gartland and Lubitz. Their results and conclusion suggest that lobectomy and total …
To: David N Parente, Pim J Bongers, Raoul Verzijl, Lorne E Rotstein, Sylvia L Asa, Wouter P Kluijfhout, Karen M Devon, David P Goldstein, Ozgur Mete, Jesse D ...
Hi, Im hoping to get some clarity on the findings of my biopsy report. I dont have it in front of me, but the report listed a few different type of cells. Follicular Carcinoma is the one my Endocron...
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For the rest of the talk Im really going to treat papillary and follicular carcinomas together as far as treatment decisions are concerned. The prognostic
FOLLICULAR NEOPLASMS (with emphasis on lesions of the inconstant portion of the hair follicle, particularly the follicular sheaths): Hair follicles are subject to a remarkable number of both inflammatory diseases, and an array of distinctive neoplasms. Follicles are epithelial structures whose histologic patterns patterns can be correlated with inherent cyclic phenomena; such correlations are a must in attempts to meaningfully classify follicular neoplasms. At regular intervals, with the phenomena of an individual follicle mostly independent of the activity of neighboring follicles, an immature follicle matures and, after an interval of generative activity, regresses to then assume a resting state; after an interval of rest, the phenomena are repeated. Inflammatory diseases, and trauma can alter the cyclic phenomena. A resting follicle is small. It composed of uniform squamous cells. Small cords of small squamous cells often project from the surface of such a structure (F5Ch12); a limited domain ...
Hi i had Stage 1 follicular cancer with Hashimoto disease which is a autoimmune disease.. I am now 10 years cancer free but still have to deal with the autoimmune part.. Since having my thyroid out i can say i am a lot healthier.. What i have noticed is that my endurance is not like it was. Also when i do push my body it take a bit longer to recover.. My para thyroids were knocked around so they are not working fully so i was having some nasty leg cramps till i got on to some magnesium.. As for my Hashimotos i believe it is greatly affected by what i eat and lets just say it is a work in progress and i am human and dont always eat healthy.. So yes there are autoimmune diseases and you need to find our from your endocronolygist which one you have.. Hope this helps in your research.. ...
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on the follicular tumour, from a highly experienced rat breeder on the NFRS forum. There are apparently different types and some contain hair follicules. They can get quite big, which I can imagine as Charlottes was growing fairly quickly and theres no particular reason why some rats get them. The good news is that its…
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Follicular thyroid carcinoma (FTC) is the second most common type of thyroid cancer after papillary carcinoma. It usually grows slowly and is clinically indolent; but rarely, its aggressive forms with distant metastases can occur. We report here an uncommon case of bilateral orbital metastasis of FTC. A 70-year-old woman presented with bilateral exophtalmus and past medical history of thyroid nodule surgery 15 years ago. Radiologic evaluation showed massive bilateral orbital mass with extension to calvarium. Tumor decompressed and removed with the suction and curettage and the patient was treated with chemoradiotherapy after operation. Pathologic examination showed metastatic follicular thyroid carcinoma. Although orbital metastasis of follicular thyroid carcinoma is uncommon, FTC should be considered as a potential primary neoplasm in a patient with orbital mass
TY - JOUR. T1 - Follicular thyroid carcinoma with skull metastases. AU - Chiofalo, Maria Grazia. AU - Setola, Sergio Venanzio. AU - Di Gennaro, Francesca. AU - Fulciniti, Franco. AU - Catapano, Giuseppe. AU - Losito, Nunzia Simona. AU - Sandomenico, Fabio. AU - Catalano, Orlando. AU - Pezzullo, Luciano. PY - 2015. Y1 - 2015. N2 - Thyroid carcinoma with distant metastases at initial presentation, is uncommon. Skull metastases occur very rarely, with a reported incidence of 2.5-5.8%. Here we report two cases of follicular thyroid cancer with skull involvement, and describe the diagnostic and therapeutic approach to metastatic thyroid cancer. We present the cases of a 70-year-old female and a 74-year-old female who presented with painless, large slow-growing masses of the skull. The patients underwent surgical excision of the skull masses, which were histologically diagnosed as metastatic follicular thyroid cancer, and total thyroidectomy, which confirmed the diagnosis of follicular thyroid ...
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was previously classified as an encapsulated follicular variant of papillary thyroid carcinoma, necessitating a new classification as it was recognized that encapsulated tumors without invasion have an indolent behavior, and may be over-treated if classified as a type of cancer. Definition of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A noninvasive neoplasm that arises from the thyroid follicular cells (cells that normally make thyroid hormone), showing a predominantly follicular growth pattern and with nuclear features of papillary thyroid carcinoma. There are several specific inclusion and exclusion criteria (see below). When these are met, this tumor has an extremely low malignant potential. Abbreviations: NIFTP: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features EFVPTC: Encapsulated follicular variant of ...
Six patients experienced voice change immediately after RFA. Voice change was recovered in 5 patients. One patient without recovery was treated with vocal cord medialization. All 6 patients with voice change had tumors in the level VI. There were no other significant complications, and most of the patients tolerated the RFA procedure well. Although some patients reported a burning sensation, pain, or both, the symptoms were relieved by reducing the RF power or stopping the ablation for several seconds.. In conclusion, RFA can be effective in treating loco-regional, recurrent, and well-differentiated thyroid carcinoma in patients at high surgical risk.. ...
Surgery of well-differentiated thyroid carcinoma: the pendulum swings back in the central neck. Endocr Pract. 2010 Sep-Oct; 16(5):913-7 ...
Background: Recent decades have seen a rise in the incidence of well-differentiated (mainly papillary) thyroid carcinoma around the world. In Germany, the age-adjusted incidence of well-differentiated thyroid carcinoma in 2010 was 3.5 per 100 000 men and 8.7 per 100 000 women per year. Method: This review is based on randomized, controlled trials and multicenter trials on the treatment of well-differentiated thyroid carcinoma that were retrieved by a selective literature search, as well as on three updated guidelines issued in the past two years. Results: The recommended extent of surgical resection depends on whether the tumor is classified as low-risk or high-risk, so that papillary microcar cinomas, which carry a highly favorable prognosis, will not be overtreated. More than 90% of localized, well-differentiated thyroid carcinomas can be cured with a combination of surgery and radioactive iodine therapy. Radio active iodine therapy is also effective in the treatment of well-differentiated ...
Inclusion Criteria: - Histologically confirmed locally advanced or metastatic thyroid cancer - Measurable disease - Normal blood pressure (if history of hypertension, blood pressure must be controlled with medication) - Evidence of disease progression within 6 months before starting study (for differentiated thyroid cancer subjects) - Evidence of disease progression within 6 months before starting study OR symptomatic disease (for medullary thyroid cancer subjects) - Not a candidate for surgical resection, external beam radiotherapy, radioiodine therapy, or other local therapy - At least 18 years of age Exclusion Criteria: - Undifferentiated/anaplastic thyroid cancer - Untreated or symptomatic brain metastases - Prior malignancy, unless cured with treatment and no evidence of disease for greater than or equal to 3 years before starting study (history of thyroid cancer, in situ cervical cancer, or basal cell cancer of skin are exceptions) - Myocardial infarction or any unstable cardiac condition ...
Papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) are the two most common thyroid cancers. They account for 90% to 95% of all thyroid malignancies and are most often seen in patients over 40 years of age (1). The tumor usually presents as an asymptomatic solitary intrathyroid nodule. In patients with FTC, distant metastases at the time of diagnosis are reported in 11% to 20% of patients (2). FTC tends to metastasize hematogeneously to lung and bone, whereas PTC is commonly metastatic to regional lymph nodes and lung. Synchronous lung metastasis in both types of cancers has been reported in ∼20% of cases, with a mean age at presentation of ,50 years (3).. Despite being classified collectively as well-differentiated thyroid carcinoma, PTC and FTC have distinct clinicopathologic features, biological behavior, and clinical outcome (4, 5). FTC is generally considered to be a more aggressive tumor than PTC and is associated with a worse prognosis. Patients with FTC often present ...
The thyroid is the organ that has the greatest risk of malignant tumors among the endocrine tumors. The papillary carcinoma occupies 80% of the entire thyroid tumors. Immunohistochemical staining of galectin-3 has usually been used in differentiating papillary carcinoma and follicular carcinoma. The p53 gene of the cell cycle is a tumor suppressor gene acting in on the control points. The cyclin D1 genes in the cell cycle, involved in the implementation of G1 and S phase, plays an important role in the progression of thyroid tumors. This research compares and analyzes correlation between papillary carcinoma, follicular carcinoma, p53, cyclin D1 and galectin-3 gene expression patterns. In a total of 30 cases from papillary carcinoma, 21 cases from p53 (70%), 27 cases in galectin-3 (90%), and 26 cases in cyclin D1 (86.7%) showed positive rate. The galectin-3 staining investigated, showed a significant difference between a papillary carcinoma and a follicular carcinoma. Follicular carcinoma from 15 ...
Anaplastic thyroid cancer arises from cells of the thyroid, which are normally involved in production and secretion of thyroid hormones, thyroxine (T4) and triiodothyronine (T3). Anaplastic thyroid tumor is always considered as stage IV. Genes involved in the pathogenesis of follicular thyroid cancer include P53 and BRAF. ...
Thyroid cancers are malignant tumors in the thyroid gland. DNA polymorphisms are playing a decisive role in unscrambling the genomic basis of tumor formation and development in cancer. Thyroid cancer is influenced in a polygenic and low-penetrance manner by RET gene polymorphisms and this part of the world (North India) has not recorded any study regarding RET alterations in this very cancer. We assessed RET G691S (rs1799939), L769L (rs1800861) and S904S (rs1800863) polymorphisms by restriction fragment length polymorphism (RFLP) in order to explain their potential role in the diagnosis and prognosis of Papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC). In RET G691S polymorphism, the total dissemination of variant alleles (GA + AA) was 62.9% in cases as related to 44.5% in controls (P < 0.05). RET L769L variant alleles (TG + GG) was 70% in cases versus 88% in controls (P < 0.05). In RET S904S, occurrence of variant alleles (CG + GG) was 56% in cases versus 44% in controls (P <
Persistent RET activation is a frequent event in papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC). In these cancers, RET activates the ERK/MAPK, the PI3K/AKT/mTOR and the JAK/STAT3 pathways. Here, we tested the efficacy of a JAK1/2- inhibitor, AZD1480, in the in vitro and in vivo growth of thyroid cancer cell lines expressing oncogenic RET. Thyroid cancer cell lines harboring RET/PTC1 (TPC-1), RET M918T (MZ-CRC1) and RET C634W (TT) alterations, as well as TPC-1 xenografts, were treated with JAK inhibitor, AZD1480. This inhibitor led to growth inhibition and/or apoptosis of the thyroid cancer cell lines in vitro, as well as to tumor regression of TPC-1 xenografts, where it efficiently blocked STAT3 activation in tumor and stromal cells. This inhibition was associated with decreased proliferation, decreased blood vessel density, coupled with increased necrosis. However, AZD1480 repressed the growth of STAT3- deficient TPC-1 cells in vitro and in vivo, demonstrating that its effects
Second of a new series of Mini-Editorials in Thyroid News. While accounting for only 1% of solid malignancies, thyroid carcinoma is the most common malignancy of the endocrine system. The majority are patients with well-differentiated thyroid carcinoma of follicular cell origin who are cured with adequate surgical management and radioiodine therapy. However, some thyroid malignancies, such as medullary thyroid carcinoma (MTC) or poorly differentiated thyroid carcinoma, frequently metastasize, precluding patients from a curative resection.. The molecular bases of differentiated thyroid carcinoma, MTC, and anaplastic thyroid cancer are well characterized and the critical genetic pathways involved in the development of specific tumor histological types have been elucidated. Of primary importance has been the recognition of key oncogenic mutations such as BRAF, RET and RAS in papillary (PTC) and RET in medullary (MTC) carcinomas. These genes code for kinases that activate signalling through the ...
The vast majority of low grade follicular cell derived thyroid carcinomas follows an indolent clinical course and is associated with very low mortality. Risk stratification using multiple clinical and pathologic characteristics has become the standard of care to guide appropriate management and avoid overtreatment. Over the past few decades, the field of thyroid pathology has witnessed several major changes that significantly impacted upon patients care. These are: 1) The reclassification of non-invasive encapsulated follicular variant of papillary thyroid carcinoma as noninvasive follicular thyroid neoplasm with papillary-like nuclear features; 2) the diagnosis of Hurthle cell carcinoma based on the presence of capsular and vascular invasion; 3) a detailed definition of poorly differentiated thyroid carcinoma, taking into consideration mitosis and necrosis; and 4) the emphasis on a detailed pathologic analysis such as the extent of vascular invasion and extrathyroidal extension ...
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Sample type RNA Source Name follicular thyroid adenoma Organism(s) Homo sapiens Characteristics tumor: follicular thyroid adenoma age: 34 gender: Female Extracted molecule total RNA Extraction protocol Total RNA was extracted from 5-10 10µm slices of snap frozen material using the Qiagen RNeasy Mini kit according to manufacturers instructions. Label Digoxigenin Label protocol 1 microgram of total RNA was reverse transcribed, amplified and digoxigenin (DIG)-labeled using the Applied Biosystems Chemiluminescent RT-IVT Labeling Kit V.2.0 according to manufacturers instructions (Part Number 4363142 Rev.A). Hybridization protocol 10µg of DIG-labeled cRNA were hybridized to the Applied Biosystems Human Genome Survey Microarray V.2.0 using the Applied Biosystems Chemiluminescence Detection Kit according manufacturers instructions (Part Number 4346875D). Scan protocol The chemiluminescent signal detection, image acquisition and image preprocessing of the microarrays were performed on the ...
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a borderline thyroid tumour formerly known as noninvasive encapsulated follicular variant of papillary thyroid carcinoma. The prevalence of NIFTP is estimated at 4.4-9.1% of all papillary thyroid carcinomas worldwide; however, the rate of occurrence of NIFTP is eight times lower in Asian countries than in Western Europe and America. At the molecular level, NIFTP is characterised by the lack of BRAF V600E and BRAF V600E-like mutations or other high-risk mutations (TERT, TP53) and a high rate of RAS mutations, which is similar to other follicular-pattern thyroid tumours. The diagnosis of NIFTP can only be made after histological examination of the entire tumour removed during surgery and is based on strictly defined inclusion and exclusion criteria. Although the diagnosis is postoperative, the combination of certain findings of preoperative tests including ultrasonography, cytology, and molecular testing may ...
A summary of results from an international phase III trial that compared sorafenib (Nexavar®) and a placebo for the treatment of locally advanced or metastatic differentiated thyroid cancer that is no longer responding to treatment with radioactive iodine
05 Feb 2016. The incidence of differentiated thyroid cancer, which includes papillary and follicular cancers, has increased nearly threefold in the United States over the past three decades, and breast cancer is the most commonly diagnosed malignancy in women.. Advances in detection and treatment have resulted in many women surviving their initial illness, Grogan said.. We now have large numbers of women who have survived one of the cancers. We saw evidence in the clinic that women who survived one seemed vulnerable to later developing the other, Grogan said.. Grogan and fellow researchers analysed studies of breast and thyroid cancer over several decades through a review of PubMed and Scopus databases.. The researchers queried the databases to find studies in which women who had survived either breast or thyroid cancer developed the other type later.. They then calculated odds ratios based on the numbers of observed and expected secondary malignancies.. The results showed that women who had ...
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Sulforaphane (SFN) an all natural compound produced from broccoli/broccoli sprouts continues to be proven used seeing that an RITA (NSC 652287) antitumor agent in various types of malignancies. cell routine arrest and apoptosis and inhibited thyroid tumor cell migration and invasion by suppressing epithelial-mesenchymal changeover (EMT) procedure and appearance of and appearance with the activation of Erk and p38 signaling cascades and marketing mitochondrial-mediated apoptosis via reactive air species (ROS)-reliant pathway. Development of xenograft tumors produced from thyroid tumor cell range FTC133 in nude mice was also considerably inhibited by SFN. Significantly we didnt find significant aftereffect of SFN in body liver RITA (NSC 652287) organ and weight function of mice. Collectively we for the very first time demonstrate that SFN is certainly a possibly effective antitumor agent for thyroid tumor. types of either at the original presentation or being a recurrence which is certainly ...
Note: The determination of AJCC stage group from T, N, and M for thyroid depends on histologic type, grade, and age. The Histologies, Grade, Stage table shows the selection of the AJCC Stage table based on histology and grade. For papillary and follicular carcinomas, age is also needed for the selection; if age at diagnosis is unknown, AJCC stage will be derived as unknown for these histologies ...
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The most common sites of metastatic differentiated thyroid cancer are the neck lymph nodes, while distant metastases typically involve the lungs, the bones, and less frequently the brain. Uncommon...
Děkujeme Vám za návštěvu Eurocytology. Zúčastnil/a byste se našeho krátkého průzkumu, abychom mohli stránku dále zdokonalit ...
Thyroglobulin (TG) levels can be elevated in well-differentiated papillary or follicular adenocarcinoma. It is often used to ... non-cancerous tumor Thyroid cancer Papillary Follicular Medullary Anaplastic Lymphomas and metastasis from elsewhere (rare) ...
LCS may be associated with other malignancies as well, such as follicular lymphoma, adenocarcinoma, and germ cell tumors. ... Langerhans cell histiocytosis Langerhans cell sarcoma Interdigitating dendritic cell sarcoma/tumor Follicular dendritic cell ...
In the thyroid, follicular and parafollicular cells are also positive for TTF-1. For lung cancers, adenocarcinomas are usually ... TTF1 is more than merely a clinical marker of lung adenocarcinoma. It plays an active role in sustaining lung cancer cells in ... This results in mucinous lung adenocarcinoma, a source of poor clinical outcomes for patients. However others have found that ... July 2007). "Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1". Cancer Research. 67 ...
Pericytic-like follicular adenoma (e) is characterized by a proliferation of spindle follicular cells concentrically arranged ... Thyroid metastasis from lung adenocarcinoma (a, b). Some metastatic tumor cells (right) are positive for thyroglobulin due to ... Follicular patterned medullary thyroid carcinoma (MTC) (a). In this other follicular patterned MTC (b), there are several ... Nearly 80 percent of thyroid cancer is papillary and about 15 percent is follicular; both types grow slowly and can be cured if ...
B cells have been implicated in the developmental of M cells, since they are also localized in high numbers in the follicular- ... Similarly, a human lymphoma cell line is also known to undergo transition from adenocarcinoma cells to M cells. Though many ...
Neoplastic thyroid gland follicular signet ring cell Signet ring adenocarcinoma cell Signet ring melanoma cell Signet ring ...
The highest levels of Ras mutations are found in adenocarcinoma of the pancreas (90%), colon (50%), and lung (30%) Bos, 1989). ... follicular thyroid adenoma, Renal cell carcinoma, urinary bladder Transitional cell carcinoma, esophagus squamous cell ... The proliferation of Caco-2 human epithelial colorectal adenocarcinoma cells in culture was stimulated by 12-HETE and inhibited ... carcinoma, colon adenocarcinoma, the Serous cystadenocarcinoma type of ovarian cancer, and uterine cervical carcinoma. Other ...
... adenocarcinoma, clear cell MeSH C04.557.470.200.025.060 - adenocarcinoma, follicular MeSH C04.557.470. - ... follicular MeSH C04.557.470.200.025.095 - adenocarcinoma, scirrhous MeSH C04.557.470. - linitis plastica MeSH ... carcinoma, papillary, follicular MeSH C04.557.470.200.025.075 - adenocarcinoma, mucinous MeSH C04.557.470.200.025.085 - ... follicular MeSH C04.557.386.480.350.350 - lymphoma, large-cell, follicular MeSH C04.557.386.480.350.525 - lymphoma, mixed-cell ...
M8330/3 Follicular adenocarcinoma, NOS (C73.9) Follicular carcinoma, NOS M8331/3 Follicular adenocarcinoma, well differentiated ... follicular variant (C73.9) Papillary adenocarcinoma, follicular variant Papillary and follicular adenocarcinoma Papillary and ... C73.9) Follicular carcinoma, well differentiated M8332/3 Follicular adenocarcinoma, trabecular (C73.9) Follicular carcinoma, ... follicular/follicle center, NOS M9691/3 Follicular lymphoma, grade 2 Follicular lymphoma, small cleaved cell M9698/3 Follicular ...
Primary cutaneous follicular lymphoma (follicular center cell lymphoma, follicular center lymphoma) Primary cutaneous ... Aggressive digital papillary adenocarcinoma (digital papillary adenocarcinoma, papillary adenoma) Apocrine gland carcinoma ... follicular mucinosis, Pinkus' follicular mucinosis-benign primary form) Localized lichen myxedematosus Myxoid cyst (digital ... follicular atrophoderma and basal cell carcinomas) Beare-Stevenson cutis gyrata syndrome Bloom syndrome (Bloom-Torre-Machacek ...
... of the testes activin receptor-like kinase-1-negative anaplastic large cell lymphoma of the testes pediatric-type follicular ... Adenoma Carcinoma Tumors of the paratesticular structures Adenomatoid tumor Malignant and benign mesothelioma Adenocarcinoma of ...
Adenocarcinoma of the lung Bronchial adenomas/carcinoids Small cell lung cancer Mesothelioma Non-small cell lung cancer Non- ... Chronic lymphocytic leukemia Chronic myelogenous leukemia Cutaneous T-cell lymphoma Diffuse large B-cell lymphoma Follicular ... Non-Hodgkin lymphoma Precursor B lymphoblastic leukemia Primary central nervous system lymphoma Primary cutaneous follicular ...
MiRNAs influence B cell maturation, generation of pre-, marginal zone, follicular, B1, plasma and memory B cells. Another role ... but not in sporadic colonic adenocarcinoma that lack mucinous components. In-vitro studies suggested that miR-205 and miR-373 ...
A Phase 2 Trial of Immunotherapy With Mitumprotimut-T (Id-KLH) and GM-CSF Following Rituximab in Follicular B-cell Lymphoma - ... resistant adenocarcinoma of the lung (NSCLA) - Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol ... Bortezomib, bendamustine, and rituximab in patients (pts) with relapsed (rel) or refractory (ref) follicular lymphoma (FL): ... Phase II trial of vatalinib in patients with advanced or metastatic pancreatic adenocarcinoma who failed gemcitabine therapy - ...
April 2012). "IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin ... Blockade of this receptor can improve the NK cells antitumor activity in esophageal cancer, melanoma and lung adenocarcinoma. ... melanoma and follicular B-cell non-Hodgkin lymphoma. The HAVCR2 pathway may interact with the PD-1 pathway in the dysfunctional ...
The most common malignancies associated with the syndrome are adenocarcinoma of the breast (20%), followed by adenocarcinoma of ... In the setting of thyroid cancer or a follicular adenoma, a total thyroidectomy is recommended even in cases where it appears ... It is estimated that less than 10 percent of individuals with Cowden syndrome may develop follicular thyroid cancer. Cases of ... Thyroid Two thirds of patients have thyroid disorders, and these typically include benign follicular adenomas or multinodular ...
"Colloid-Rich" follicular neoplasm/suspicious for follicular neoplasm thyroid fine-needle aspiration specimens: Cytologic, ... RET rearrangements in lung adenocarcinoma and radiation. J Thorac Oncol. 2014 Jan;9(1):118-20. Dettmer MS, Perren A, Moch H, ... Highly accurate diagnosis of cancer in thyroid nodules with follicular neoplasm/suspicious for a follicular neoplasm cytology ... PAX8/PPARγ Rearrangement in Thyroid Nodules Predicts Follicular-Pattern Carcinomas, in Particular the Encapsulated Follicular ...
It is considered an adenocarcinoma. There are two subtypes: sporadic (that is, non-hereditary) and hereditary. Both such ... Multilocular cystic clear cell renal cell carcinoma Tubulocystic renal cell carcinoma Thyroid-like follicular renal cell ...
In Non Hodgkin lymphoma, the ID4 promoter region is implicated in follicular lymphomas, diffuse B Cell lymphomas and lymphoid ... The ID4 promoter region is hypermethylated and infrequently expressed in gastric adenocarcinomas and frequently expressed in ... "Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma". Oncogene. 22 (44): 6946-53. doi:10.1038/sj.onc. ... "Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma". Oncogene. 22 (44): 6946-6953. doi:10.1038/sj.onc ...
"FDA approves new treatment for adults with relapsed follicular lymphoma". US Food and Drug Administration. September 14, 2017. ... "Mutations of PIK3CA in gastric adenocarcinoma". BMC Cancer. 5: 29. doi:10.1186/1471-2407-5-29. PMC 1079799. PMID 15784156. ... got FDA approval for the treatment of adult patients with relapsed follicular lymphoma (FL) who have received at least two ...
... is found to be overexpressed in malignant follicular thyroid nodules. In conjunction with cyclin A and galectin-3, HK3 ... "Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma". Histology and ... cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules". Clinical Endocrinology. 68 (2): 252-7. doi: ...
Over time adenomas may transform to become malignant, at which point they are called adenocarcinomas. Most adenomas do not ... especially when the cells found at biopsy are of the follicular type. Pituitary adenomas are seen in 10% of neurological ...
The term "CYLD cutaneous syndrome" as applied to individuals with MFT1, BSS, or FC hair follicular tumors and carrying a ... These malignant tumors may metastasize to non-cutaneous tissues such as the salivary glands (i.e.basal cell adenocarcinomas of ... Some of these tumors resemble basal-cell carcinomas or adenocarcinomas. ...
2004). "CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells". ... 50/90-like molecule on follicular keratinocytes". Arch. Dermatol. Res. 289 (8): 457-65. doi:10.1007/s004030050221. PMID 9266023 ...
An extreme example of a group of cancer, Esophageal adenocarcinomas, which are hardly distinguishable by morphology, makes ... Most lymphoma identities may be characterized by chromosome translocations, for example, follicular lymphoma (FL) t(14;18), ... Using cDNA microarrays, the genetic variations of subtypes of oesophageal adenocarcinomas are profiled and the prognosis of ... This is because nearly all oesophageal adenocarcinomas arise from Barrett's mucosa. ...
Vaginal adenocarcinoma arises from secretory cells in the epithelium Clear cell adenocarcinoma of the vagina arises in response ... During the luteal and follicular phases of the estrous cycle the structure of the vaginal epithelium varies. The number of cell ...
Endometrioid adenocarcinoma from biopsy. H&E stain. Micrograph of decidualized endometrium due to exogenous progesterone. H&E ... Proliferation is induced by estrogen (follicular phase of menstrual cycle), and later changes in this layer are engendered by ... Baerwald, A. R.; Pierson, R. A. (2004). "Endometrial development in association with ovarian follicular waves during the ...
In women, the levels in follicular fluid exceed those of non-pregnant women. ·Seminal plasma: PP-14 is a significant protein ... in endometrial adenocarcinoma and effect of medroxyprogesterone acetate". British Journal of Obstetrics and Gynaecology. 95 (12 ... Is secreted by granulosa cells into the follicular fluid. Glycodelin-F reduces the blinding of spermatozoa to the zona ... First, cumulus cells reduce the spermatozoa-zona binding inhibitory activity of follicular fluid probably by taking up and ...
... follicular large cell lymphoma - follicular mixed cell lymphoma - follicular thyroid cancer - formaldehyde - FR901228 - ... clear cell adenocarcinoma - clear-cell sarcoma - clear cell sarcoma of the kidney - clinical breast exam - clinical resistance ... thyroid follicular cell - thyroid hormone - thyroid-stimulating hormone - thyroidectomy - thyrotropin alfa - tiazofurin - time ... adenocarcinoma - adenoid cystic cancer - adenoma - adenopathy - adenosine triphosphate - adenovirus - adjunct agent - ...
"Deoxythymidine kinase in the staging of prostatic adenocarcinoma". The Prostate. 29 (1): 15-9. doi:10.1002/(SICI)1097-0045( ... "High baseline serum thymidine kinase 1 level predicts unfavorable outcome in patients with follicular lymphoma". Leukemia & ...
EGFR Adenocarcinoma of lung, somatic; 211980; BRAF Adenocarcinoma of lung, somatic; 211980; ERBB2 Adenocarcinoma of lung, ... follicular; 188470; MINPP1 Thyroid carcinoma, follicular; 188470; NRAS Thyroid carcinoma, papillary; 188550; GOLGA5 Thyroid ... somatic; 211980; PRKN Adenocarcinoma, ovarian, somatic; 604370; PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, ... ACADS Adenocarcinoma of lung, response to tyrosine kinase inhibitor in; 211980; ...
Menopause is the permanent cessation of menstruation resulting from loss of ovarian follicular activity, defined as beginning ... decreased risk of cervical squamous cell cancer in post menopausal women treated with HRT and a weak increase in adenocarcinoma ...
However, in women, a sharp increase in estradiol levels to about 200 to 500 pg/mL occurs at the end of the follicular phase ( ... "Endocrine effects of oestrogen withdrawal in long-term treated patients with prostatic adenocarcinoma". Eur. Urol. 14 (1): 6-8 ...
Research comparing gene expression between primary and metastatic adenocarcinomas identified a subset of genes whose expression ... such as renal cell carcinoma originating in the kidney and follicular carcinomas of the thyroid. Because of their thinner walls ... adenocarcinoma)-lower two-thirds of image). H&E stain. Metastatic cancer in the lungs Metastases from the lungs to the brain ... the expression of these metastatic-associated genes was shown to apply to other cancer types in addition to adenocarcinoma. ...
This trend is seen in cancers such as colorectal carcinoma and follicular lymphoma. This could be due to Treg cells' ability to ... "Association of Foxp3 rs3761548 polymorphism with cytokines concentration in gastric adenocarcinoma patients". Cytokine. 138: ...
De Pasquale, P. Paterlini, A. Di Francesco, L. Vecchio, D. Quaglino : Follicular lymphomas with predominant splenic involvement ... Detection of circulating prostate-derived cells in patients with prostate adenocarcinoma through an optimized RT-PCR procedure ...
Mucinous tumors include mucinous adenocarcinoma and mucinous cystadenocarcinoma. Mucinous adenocarcinomas make up 5-10% of ... including ovarian follicular cyst, leiomyoma, endometriosis, ectopic pregnancy, hydrosalpinx, tuboovarian abscess, ovarian ... Clear-cell adenocarcinomas are histopathologically similar to other clear cell carcinomas, with clear cells and hobnail cells. ... Advanced mucinous adenocarcinomas have a poor prognosis, generally worse than serous tumors, and are often resistant to ...
Metastatic pulmonary adenocarcinoma. involving brain. Dexamethasone (4 mg) leading up to resection; rituximab/bendamustine ... treatment completed 18 mo before resection for follicular lymphoma. Endothelium. Ground level fall, confusion, forgetfulness, ...
Categories: Adenocarcinoma, Follicular Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
... oxyphilic adenocarcinoma = 8290, follicular adenocarcinoma NOS = 8330, papillary carcinoma follicular variant = 8340, papillary ... Yu, X.-M.; Schneider, D.F.; Leverson, G.; Chen, H.; Sippel, R.S. Follicular Variant of Papillary Thyroid Carcinoma is a Unique ... Histology is based on International Classification of Diseases for Oncology (ICD-O-3) coding: Papillary adenocarcinoma NOS = ...
All 5 cases were hematologic malignancies, either DLBCL or follicular lymphoma. Three of the 30 (10%) cases were later ... The other 4 malignancies were pancreatic adenocarcinoma, squamous cell carcinoma, melanoma, and seminoma. ... diagnosed with hematologic malignancies (DLBCL, follicular lymphoma, anaplastic large cell lymphoma). Of the 4 patients with no ...
Follicular lymphoma. Multiple myeloma. Pancreatic cancer. Gastric cancer, including gastroesophageal junction adenocarcinoma ...
CD4⁺ follicular helper T cell infiltration predicts breast cancer survival. J CLIN INVEST. 2013;123:2873-92 ... BIRC5 Modulates PD-L1 Expression and Immune Infiltration in Lung Adenocarcinoma Teng Ma*, Jie Gu*, Haoyu Wen*, Fengkai Xu , Di ... Ma T, Gu J, Wen H, Xu F, Ge D. BIRC5 Modulates PD-L1 Expression and Immune Infiltration in Lung Adenocarcinoma. J Cancer 2022; ... Ma T, Gu J, Wen H, Xu F, Ge D. BIRC5 Modulates PD-L1 Expression and Immune Infiltration in Lung Adenocarcinoma. J Cancer 2022; ...
result sql = Follicular adenocarcinoma. Follicular adenocarcinoma 17. char = l;code = 108. char = y;code = 121. char = m;code ... start str = Papillary adenocarcinoma. sql str = Papillary adenocarcinoma. start str = salivary glands. sql str = salivary ... See more studies on Papillary adenocarcinoma and.... How is this determined? The order of these related concepts is determined ...
We examined 32 primary pancreatic adenocarcinomas for CDKN2 mutations and for loss of heterozygosity of 9p21 sequences to ... plays an important role during tumorigenesis or tumor progression in a significant proportion of pancreatic adenocarcinomas. ... plays an important role during tumorigenesis or tumor progression in a significant proportion of pancreatic adenocarcinomas. ... and loss of 9p sequences suggests a role for a tumor suppressor gene in the development of follicular and anaplastic thyroid ...
Follicular lymphoma Gastric cancer Gastro-oesophageal junction adenocarcinoma Gastro-oesophageal junction cancer ...
papillary follicular thyroid adenocarcinoma DOID:3968 * congenital disorder DOID:759 * Rothmund-Thomson syndrome ...
... resulted in increases in mammary gland adenocarcinomas (females) and thyroid gland follicular cell adenomas and carcinomas ( ... The mechanism for the increase in mammary adenocarcinomas is unknown. The increase in thyroid tumors is thought to be due to ...
Follicular Adenocarcinoma Medicine & Life Sciences 100% * ras Genes Medicine & Life Sciences 85% ... Selective activation of ras oncogenes in follicular and undifferentiated thyroid carcinomas. G. Manenti, S. Pilotti, F. C. Re, ... In our cases, mutations in all three ras oncogenes were found in follicular carcinomas (five out of 21) and in the less ... Manenti, G, Pilotti, S, Re, FC, Della Porta, G & Pierotti, MA 1994, Selective activation of ras oncogenes in follicular and ...
Follicular lymphoma Gastric cancer Gastro-oesophageal junction adenocarcinoma Gastro-oesophageal junction cancer ...
Adenocarcinomas, Follicular Carcinoma, Follicular Thyroid Carcinomas, Follicular Thyroid Follicular Adenocarcinoma Follicular ... Carcinomas, Follicular Thyroid. Follicular Adenocarcinoma. Follicular Adenocarcinomas. Follicular Thyroid Carcinoma. Follicular ... Follicular Thyroid Carcinoma Follicular Thyroid Carcinomas Thyroid Carcinoma, Follicular Thyroid Carcinomas, Follicular ... Adenocarcinoma, Follicular - Preferred Concept UI. M0027492. Scope note. An adenocarcinoma of the thyroid gland, in which the ...
Follicular adenocarcinoma (morphologic abnormality). Code System Preferred Concept Name. Follicular adenocarcinoma (morphologic ...
Yu L, Todd NW, Xing L, Xie Y, Zhang H. Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers. Int J ... Thyroglobulin (Tg): It is used in diagnosis and prognosis of papillary and follicular thyroid cancer. Tg can be measured in ... is very helpful in early detection of prostate adenocarcinoma. ...
In this study, we found that gene GGT5 was highly expressed in cancer-associated fibroblasts (CAFs) in lung adenocarcinoma, ... predicting the unfavorable survival of patients with lung adenocarcinoma. Cell growth, foci formation and spheres formation ... indicating that GGT5 may be a promising therapeutic target in lung adenocarcinoma. ... One recent study showed that GGT5 highly expressed in follicular dendritic cells promoting B cell confinement to germinal ...
Metastatic pulmonary adenocarcinoma. involving brain. Dexamethasone (4 mg) leading up to resection; rituximab/bendamustine ... treatment completed 18 mo before resection for follicular lymphoma. Endothelium. Ground level fall, confusion, forgetfulness, ...
Adenocarcinoma. *Anaplastic thyroid cancer. *Follicular thyroid cancer. *Lymphoma. *Medullary thyroid cancer. *Melanoma ...
... causes invasive multilayering of the follicular epithelia. Analyzing the integrated Lgl-KD and wildtype transcriptomes, we ... In lung adenocarcinoma (LUAD), OS was based on 672 patients and FP on 443 patients. In lung squamous carcinoma (LUSC), OS was ... We describe human COX6B2, a component of cytochrome c oxidase (complex IV). COX6B2 is expressed in human lung adenocarcinoma ( ... COX6B2 is expressed in human lung adenocarcinoma (LUAD) tumors and correlates with poor survival. Using a large-scale ...
The method of claim 12, wherein the cancer is esophageal adenocarcinoma. 15. The method of claim 1 or 2, wherein the ... follicular lymphoma (FL), mantle cell lymphoma (MCL) and ALK+ anaplastic large cell lymphoma (e.g., B-cell non-Hodgkins ... 00112] In certain embodiments, the methods may be useful in the treatment of esophageal adenocarcinoma. ... metastatic pancreatic adenocarcinoma, refractory B-cell non-Hodgkins lymphoma, and relapsed B-cell non-Hodgkins lymphoma, ...
... adenocarcinoma of the small/large intestine; follicular cell adenoma of the thyroid; fibroma of the subcutis, and malignant ... Adenocarcinoma , Adenoma , Humanos , Camundongos , Ratos , Animais , Masculino , Feminino , Ratos Endogâmicos F344 , ... Furthermore, the incidence of primary lung tumors, such as adenomas and adenocarcinomas, was 65.4, 62.5, and 45.4% in the FVB- ... In females, significantly increased tumors were adenocarcinoma and fibroadenoma of the mammary gland, squamous cell papilloma ...
keywords = "Adenoma, Carcinoma, Differential diagnosis, Follicular adenocarcinoma, Frozen sections, Levothyroxine, Needle ... Follicular neoplasms: The role for observation, fine needle aspiration biopsy, thyroid suppression, and surgery. Seminars in ... Louis, J. D. S. T., Leicht, G. S., & Tyler, D. (1999). Follicular neoplasms: The role for observation, fine needle aspiration ... Follicular neoplasms : The role for observation, fine needle aspiration biopsy, thyroid suppression, and surgery. In: Seminars ...
Adenocarcinoma (Phase 2) Adenocarcinoma, Follicular (Phase 2) Adenocarcinoma, Mucinous (Phase 2) Adenoma (Phase 2) ...
Clear cell adenocarcinoma of the lung * Metastatic thyroid carcinoma, follicular variant * Metastatic clear cell carcinoma of ... Discussion: Clear cell carcinomas of the lung may be either squamous cell carcinoma or adenocarcinoma. One would expect a ... Discussion: Clear cell carcinomas of the lung may be either squamous cell carcinoma or adenocarcinoma. One would expect a ... primary pulmonary adenocarcinoma, in most cases, to demonstrate TTF-1 immunoreactivity. A metastatic well-differentiated ...
There was an increase in follicular adenomas of the thyroid in female rats receiving sertraline at 40 mg/kg (2 times the MRHD ... While there was an increase in uterine adenocarcinomas in rats receiving sertraline at 10-40 mg/kg (0.5-2.0 times the MRHD on a ...
... adenocarcinoma - follicular carcinoma of thyroid gland … Medical dictionary. *. follicular carcinoma of thyroid ... Follicular Unit Extraction - (FUE) is a technique of hair restoration that involves, direct extraction of the follicular units ... Follicular lymphoma - Classification and external resources Follicular lymphoma replacing a lymph node ICD 10 C … Wikipedia ... Follicular thyroid cancer - Classification and external resources Gross pathological section of a follicular thyroid adenoma ( ...
  • See more studies on Papillary adenocarcinoma and. (naturalnews.com)
  • Thyroid cancer can be mainly classified as papillary adenocarcinoma and follicular adenocarcinoma according to their pathological characteristics. (moderncancerhospital.com.cn)
  • Though different morphologies have been reported, the most frequent histological type of feline endometrial adenocarcinoma (FEA) is the papillary serous. (biomedcentral.com)
  • PeaceHealth offers care for different thyroid cancer (papillary, follicular and Hṻrthle cell), medullary, anaplastic and others. (peacehealth.org)
  • Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): Implications for the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). (rush.edu)
  • Included Diagnoses: Papillary, Follicular, Medullary and other carcinomas (including all subtypes), Adenocarcinoma (including all subtypes), Squamous Cell Carcinoma (including all subtypes), Neuroendocrine tumors of the thyroid (including all subtypes). (accegen.com)
  • Differentiated thyroid cancers include papillary, follicular carcinomas and are usually associated with a good prognosis. (endocrine-abstracts.org)
  • Perhaps the most useful application is the identification of Thyroid Carcinoma of the papillary type, although Follicular Carcinoma is also labeled by this antibody approximately 50-60% of the time. (affordableihcinstruments.com)
  • All 5 cases were hematologic malignancies, either DLBCL or follicular lymphoma. (medscape.com)
  • Three of the 30 (10%) cases were later diagnosed with hematologic malignancies (DLBCL, follicular lymphoma, anaplastic large cell lymphoma). (medscape.com)
  • Follicular large cell lymphoma - is a rare type of non Hodgkin lymphoma (cancer of the lymphatic system) with large cells that look cleaved (split) or non cleaved under the microscope. (en-academic.com)
  • Six-year follow-up data showed an overall survival rate of 89% among patients with follicular lymphoma who received either lenalidomide plus rituximab or immunochemotherapy. (oncnursingnews.com)
  • Lenalidomide (Revlimid) plus rituximab (Rituxan) for the frontline treatment of advanced follicular lymphoma (FL) demonstrated a similar efficacy and safety profile to rituximab plus chemotherapy (R-chemo) in a 6-year analysis of the RELEVANCE trial (NCT01650701), according to findings published in the Journal of Clinical Oncology . (oncnursingnews.com)
  • That's the day it was staged and named, Non-Hodgkin's Follicular Lymphoma. (lightthenight.org)
  • Lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) are two main pathological types of NSCLC. (aging-us.com)
  • The diagnosis and management of follicular carcinoma of the thyroid gland remains a controversial topic. (utmb.edu)
  • The extent of surgical excision of follicular carcinoma also raises several competing views. (utmb.edu)
  • Discussion: Clear cell carcinomas of the lung may be either squamous cell carcinoma or adenocarcinoma. (jhu.edu)
  • CAV1 expression was lower in lung adenocarcinoma and lung squamous cell carcinoma than in control tissues. (rarediseaseadvisor.com)
  • The researchers also found a positive correlation between CAV1 expression and immune infiltration of cancer-associated fibroblasts, endothelial, and neutrophils in lung adenocarcinoma and lung squamous cell carcinoma. (rarediseaseadvisor.com)
  • TEK expression levels were also lower in lung adenocarcinoma and lung squamous cell carcinoma tissues when compared to control tissues. (rarediseaseadvisor.com)
  • Ma T, Gu J, Wen H, Xu F, Ge D. BIRC5 Modulates PD-L1 Expression and Immune Infiltration in Lung Adenocarcinoma. (jcancer.org)
  • Lung adenocarcinoma (LUAD) is the most prevalent thoracic cancer with the highest incidence and mortality worldwide. (jcancer.org)
  • BIRC5 promotes lung adenocarcinoma progression by modulating PD-L1 expression and inducing tumor immune evasion. (jcancer.org)
  • In this study, we found that gene GGT5 was highly expressed in cancer-associated fibroblasts (CAFs) in lung adenocarcinoma, predicting the unfavorable survival of patients with lung adenocarcinoma. (aging-us.com)
  • Taken together, our study illuminates that high level of GGT5 in CAFs contributes to cancer cell survival and drug resistance, indicating that GGT5 may be a promising therapeutic target in lung adenocarcinoma. (aging-us.com)
  • COX6B2 is expressed in human lung adenocarcinoma (LUAD) and expression correlates with reduced survival time. (elifesciences.org)
  • Positive Control: Adenocarcinoma of the Lung or Thyroid for TTF-1. (scytek.com)
  • Specificity: This antibody reacts with TTF-1 protein found in adenocarcinomas of the lung and tumors originating in the thyroid. (scytek.com)
  • In lung cancers, Adenocarcinomas are usually positive, while Squamous Cell Carcinomas and Large Cell Carcinomas are rarely positive. (scytek.com)
  • This Multiplex cocktail of TTF-1 and Cytokeratin 5 produces two-color high contrast staining for differentiating primary adenocarcinoma of the Lung from Metastatic Carcinomas of the breast and Malignant Mesothelioma. (scytek.com)
  • recently investigated the roles of these cells in the setting of lung adenocarcinoma (LUAD), and their results were published in Cell. (acir.org)
  • 75% of lung non-small cell carcinomas (NSCLCs) are positive, adenocarcinomas (ACs) are significantly higher than squamous cell carcinomas (SCC), more than 90% of primary small cell lung cancers (SCLC) are positive, and TTF-1 is positive in non-small cell lung cancers (SCLC). (medicaltrend.org)
  • Zheng M , Zhou H , Xie J , Zhang H , Shen X , Zhu D . Molecular typing and prognostic model of lung adenocarcinoma based on cuprotosis-related lncRNAs. (wjgnet.com)
  • Of note, among these patients, 1 experienced chronic obstructive pulmonary disease and 2 experienced adenocarcinomas of the colon. (oncnursingnews.com)
  • The goal of this review is to address these issues and present an algorithm for the management of follicular neoplasms of the thyroid. (utmb.edu)
  • The authors' data suggest that alterations in CDKN2 played a role in a minority of thyroid cancers (three of 35), and loss of 9p sequences suggests a role for a tumor suppressor gene in the development of follicular and anaplastic thyroid cancers. (semanticscholar.org)
  • Mxi1 tumor suppressor gene is not mutated in primary pancreatic adenocarcinoma. (semanticscholar.org)
  • Follicular thyroid cancer - Classification and external resources Gross pathological section of a follicular thyroid adenoma (tumor at the bottom). (en-academic.com)
  • As a crucial step towards clinical application, we investigated tumor specificity and transfection efficiency of epidermal growth factor receptor (EGFR)-targeted polyplexes as systemic NIS gene delivery vehicles in an advanced genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC) that closely reflects human disease. (oncotarget.com)
  • The biological and clinical behavior is very unpredictable especially if it s associated with another tumor, like adenocarcinoma. (endocrine-abstracts.org)
  • Within the ovary, angiogenesis is not only integral to follicular development and the formation of the corpus luteum, but it is also a hallmark of tumorigenesis and tumor progression in ovarian cancers. (unh.edu)
  • We treat adenocarcinomas and other types of tumors, such as carcinoid tumors, gastrointestinal stromal tumors (GSITs), lymphomas and sarcomas. (peacehealth.org)
  • Another cancer hit, endometrial adenocarcinoma on November 18, 2016, almost exactly one year from diagnosis #1. (lightthenight.org)
  • 2017 (www.who.int/publications/m/item/guidance-for-the-de- (www.who.int/publications/m/item/guidance-for-the-development- velopment-of-evidence-based-vaccine-related-recommenda- of-evidence-based-vaccine-related-recommendations, consulté en tions, accessed August 2022). (who.int)
  • Follicular atresia - is the break down of the ovarian follicles. (en-academic.com)
  • Therefore, the overall objective of the present study was to identify potential regulators of CCN1 and their mechanisms of action in the ovarian adenocarcinoma cell line, OVCAR-8. (unh.edu)
  • Several conditions, including polycystic ovarian syndrome, can affect the follicular antra by keeping the ovarian follicles from growing and maturing. (conhecoumlugar.com)
  • One would expect a primary pulmonary adenocarcinoma, in most cases, to demonstrate TTF-1 immunoreactivity. (jhu.edu)
  • The p16-Leiden deletion was associated with progression toward conventional ductal adenocarcinomas in all cases but one and might also indicate that chemoprevention needs consideration. (semanticscholar.org)
  • It is specifically found in the periderm, the transientlysuperficial layer that envelopes the developing epidermis.Anti-Cytokeratin 19 reacts with a wide variety of epithelium and epithelial malignancies including Adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver and breast. (affordableihcinstruments.com)
  • Follicular dendritic cells - (FDC) are cells of the immune system found in lymph follicles. (en-academic.com)
  • In contrast, they observed a negative correlation between CAV1 expression and immune infiltration of T cell follicular helper. (rarediseaseadvisor.com)
  • CD8 + T cells are often the focus of research in cancer immunotherapy, but recent evidence has suggested that CD4 + T helper cells (particularly T follicular helper [TFH] cells) and B cells (particularly germinal center [GC] B cells) may also play important behind-the-scenes roles in supporting CD8 + T cells and antitumor immune responses. (acir.org)
  • We examined 32 primary pancreatic adenocarcinomas for CDKN2 mutations and for loss of heterozygosity of 9p21 sequences to assess the role of CDKN2 in pancreatic carcinogenesis. (semanticscholar.org)
  • In our cases, mutations in all three ras oncogenes were found in follicular carcinomas (five out of 21) and in the less differentiated thyroid tumour: poorly differentiated carcinomas (three out of 11) and undifferentiated carcinomas (one out of five). (elsevier.com)
  • An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (bvsalud.org)
  • In the thyroid, follicular and parafollicular cells are positive. (scytek.com)
  • Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell lines than in primary pancreatic adenocarcinomas. (semanticscholar.org)
  • 14. The method of claim 12, wherein the cancer is esophageal adenocarcinoma. (sumobrain.com)
  • Fine needle aspiration, although very sensitive with other types of thyroid cancer, has limited accuracy with follicular lesions. (utmb.edu)
  • Le protocole utilisé dans le traitement du myélome multiple a été le VMCD-REV à 76,92% avec pour réponse thérapeutique complète chez 6 patients, 3 réponses partielles et 4 en cours de traitement. (bvsalud.org)
  • Feline endometrial adenocarcinomas maintained the CK7+/CK20+ status of normal endometrium. (biomedcentral.com)
  • Follicular unit transplantation - is a modern hair restoration technique where the hair is transplanted in groups of 1 4 hairs - exactly as it grows in nature. (en-academic.com)
  • Follicular Unit Extraction - (FUE) is a technique of hair restoration that involves, direct extraction of the follicular units from a patient's donor area using a small instrument called a trephine. (en-academic.com)
  • Avant leur mise en forme a large group of external subject-matter définitive, elles sont examinées par un large experts and end-users. (who.int)
  • An unusual case of noninvasive adenocarcinoma arising in a localized adenomyoma of the gallbladder and review of literature. (rush.edu)