Adenocarcinoma, Mucinous
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Adenocarcinoma, Papillary
Barrett Esophagus
A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
Carcinoma, Pancreatic Ductal
Adenocarcinoma, Bronchiolo-Alveolar
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
Cardia
Immunohistochemistry
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Esophagogastric Junction
Neoplasm Staging
Prognosis
Keratin-7
Gene Expression Regulation, Neoplastic
Carcinoma, Squamous Cell
Endometrial Neoplasms
Neoplasms, Multiple Primary
Precancerous Conditions
Tumor Cells, Cultured
Carcinoma, Signet Ring Cell
Carcinoma, Endometrioid
Mammary Neoplasms, Experimental
Adenocarcinoma, Clear Cell
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
Metaplasia
Immunoenzyme Techniques
Colorectal Neoplasms
Ampulla of Vater
Genes, ras
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
Common Bile Duct Neoplasms
Keratin-20
Tissue Array Analysis
Pancreaticoduodenectomy
Survival Rate
Neoplasm Metastasis
Lymphatic Metastasis
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Carcinoma, Non-Small-Cell Lung
Carcinoembryonic Antigen
Carcinoma, Acinar Cell
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Neoplasm Transplantation
Esophagus
Disease Progression
Survival Analysis
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Gastrectomy
Mice, Nude
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Mutation
Carcinoma in Situ
Receptor, Epidermal Growth Factor
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Kaplan-Meier Estimate
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Reverse Transcriptase Polymerase Chain Reaction
Biopsy
Fatal Outcome
Antigens, Neoplasm
Treatment Outcome
Mucins
Gastrointestinal Neoplasms
Tumor Suppressor Protein p53
Pancreatic Ducts
Gene Expression Profiling
Endometrial Hyperplasia
Keratins
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Cell Transformation, Neoplastic
Ovarian Neoplasms
Prostatic Intraepithelial Neoplasia
A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
ras Proteins
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.
Carcinoma, Large Cell
Neoplasms, Experimental
Fluorouracil
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
CA-19-9 Antigen
Mucin-2
Gastric Mucosa
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Hyperplasia
Carcinoma
Combined Modality Therapy
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Carcinoma, Small Cell
Adenoma, Villous
Neoplasm Recurrence, Local
Prostate
Oligonucleotide Array Sequence Analysis
Pancreas
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Tomography, X-Ray Computed
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Neuroendocrine
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Mucin-1
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
Loss of Heterozygosity
Blotting, Western
Cystadenocarcinoma
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Genes, erbB-1
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
Mesothelioma
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
Risk Factors
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Biopsy, Needle
Proto-Oncogene Proteins
Anal Sacs
Cystadenocarcinoma, Serous
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
Cell Division
Disease-Free Survival
Ki-67 Antigen
Cyclooxygenase 2
Follow-Up Studies
Antigens, Tumor-Associated, Carbohydrate
Chemotherapy, Adjuvant
HT29 Cells
Pleural Effusion, Malignant
Mucin-4
A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.
In Situ Hybridization, Fluorescence
Gastroesophageal Reflux
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Gene Amplification
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Sensitivity and Specificity
Urachus
Multivariate Analysis
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Carcinogens
Radiotherapy, Adjuvant
Up-Regulation
Pancreatitis, Chronic
Cystadenocarcinoma, Mucinous
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
Neoplasm Grading
Incidence
Colon
Carcinoid Tumor
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
DNA Methylation
Jaagsiekte sheep retrovirus
Intestinal Mucosa
Genes, Tumor Suppressor
Drug Resistance, Neoplasm
Base Sequence
Nitrosamines
Gene Expression
Genes, p53
Carcinosarcoma
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Proportional Hazards Models
Smad4 Protein
Mice, Transgenic
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Disease Models, Animal
Neoadjuvant Therapy
Pulmonary Adenomatosis, Ovine
Cadherins
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Histocytochemistry
Membrane Proteins
Epithelium
A new rapid technique for the fixation of thyroid gland surgical specimens. (1/468)
One of the main diagnostic problems in thyroid pathology is to distinguish between follicular adenoma and follicular carcinoma. Thorough sampling of the nodule's capsule is recommended in order to identify capsular invasion. However, during the hardening of the tissue, by the usual fixatives the capsule shrinks and rolls downwards and sometimes the capsule separates from the remaining tissue. The present work evaluates the use of "Lymph Node Revealing Solution" (LNRS) for the rapid fixation (2h) of different thyroid lesions as compared to that of formalin. Fifty-one unselected consecutive cases of thyroid nodules, which included various benign and malignant lesions, were examined. Each specimen was cut in two equal parts; one was fixed in LNRS, the other in formalin. Fixation in LNRS for 2 hours gave adequate results in sectioning and staining of the tissue, and excellent immunostains. Its advantage over formalin is the conservation of the natural relationship between the capsule and the rest of the tissue, on the same plane, as well as the short time required for the final diagnosis. (+info)Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine. (2/468)
The modifying effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a mutagenic by-product in chlorinated water, on the development of glandular stomach cancers were investigated in Wistar rats. A total of 120 males, 6 weeks of age, were divided into six groups. After initiation with 100 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) solution and 5% NaCl diet for 8 weeks, 30 rats each in groups 1-3 were given MX in the drinking water at concentrations of 30, 10, or 0 ppm for the following 57 weeks. Ten animals each in groups 4-6 were administered the MX without prior carcinogen exposure. There were no statistical significant differences in final body weights between the groups. The incidences and multiplicities of adenocarcinomas in the glandular stomachs were significantly higher (P < 0.05) in the initiated 30 ppm MX group than those in the MNNG/NaCl group. The incidences of atypical hyperplasias in the glandular stomachs were also significantly increased (P < 0.05 or 0.01) by the MX treatments. With their multiplicity, the effects were clearly dose dependent. Interestingly, the 30 ppm MX alone itself induced atypical hyperplasias in the pylorus, although the incidences and severity were low. Moreover, MX showed a tendency to enhance the development of intrahepatic cholangiocellular tumors and thyroid follicular cell tumors in the MNNG-treated animals. The results of the present study thus indicate that MX exerts promoting effects when given during the postinitiation phase of two-stage glandular stomach carcinogenesis in rats. (+info)DNA copy number changes in thyroid carcinoma. (3/468)
The genetic changes leading to thyroid cancer are poorly characterized. We studied DNA copy number changes by comparative genomic hybridization (CGH) in 69 primary thyroid carcinomas. In papillary carcinoma, DNA copy number changes were rare (3 of 26, 12%). The changes were all gains, and they were associated with old age (P = 0.01) and the presence of cervical lymph node metastases at presentation (P = 0.08). DNA copy number changes were much more frequent in follicular carcinoma (16 of 20, 80%) than in papillary carcinoma (P < 0.0001), and follicular carcinomas had more often deletions (13/20 versus 0/26, P < 0.0001). Loss of chromosome 22 was common in follicular carcinoma (n = 7, 35%), it was more often seen in widely invasive than in minimally invasive follicular carcinoma (54% versus 0%, P = 0.04), and it was associated with old age at presentation (P = 0.01). In three of the four patients with follicular carcinoma who died of cancer, the tumor had loss of chromosome 22. DNA copy number changes were found in 5 (50%) of the 10 medullary carcinomas studied. Four of these five carcinomas had deletions, and in two of them there was deletion of chromosome 22. Eleven (85%) of the thirteen anaplastic carcinomas investigated had DNA copy number changes, of which five had deletions, and one had deletion of chromosome 22. The most common gains in anaplastic carcinoma were in chromosomes 7p (p22-pter, 31%), 8q (q22-qter, 23%), and 9q (q34-qter, 23%). We conclude that DNA copy number changes are frequent in follicular, medullary, and anaplastic thyroid carcinoma but rare in papillary carcinoma when studied by CGH. Loss of chromosome 22 is particularly common in follicular carcinoma, and it is associated with the widely invasive type. (+info)Relationship among 201T1 uptake, nuclear DNA content and clinical behavior in metastatic thyroid carcinoma. (4/468)
A prospective study of 201TI uptake was performed to compare 201TI uptake with nuclear deoxyribonucleic acid (DNA) content and clinical behavior of tumors in metastatic thyroid carcinoma and to assess the significance of 201TI uptake in evaluating clinical characteristics of thyroid carcinoma. METHODS: Fifty-six patients with metastases of differentiated thyroid carcinoma had 201TI scintigraphy. Grade of 201TI uptake was semiquantitatively assessed according to tumor-to-background ratio on 2-h late scan. Nuclear DNA content was analyzed within 3 wk of 201TI study by flow cytometry using biopsy material and was classified as diploidy or aneuploidy. Patients were followed up to examine incidence of tumor growth and/or anaplastic transformation. RESULTS: DNA content was diploidy in 48 patients and aneuploidy in 8 patients. 201TI uptake in the DNA-aneuploid group (2.61 +/- 0.29) was significantly higher than that in the DNA-diploid group (1.82 +/- 0.35, P < 0.01 for both groups). Tumor growth was observed in all patients with DNA aneuploidy but in only 5 of 48 patients with DNA diploidy (P < 0.01). Anaplastic transformation was observed in 3 patients in the DNA-aneuploid group but in none of the patients in the DNA-diploid group. CONCLUSION: High 201TI uptake indicates greater incidence of abnormal DNA content with aggressive clinical behavior of metastatic tumors. Thus, 201TI scintigraphy may be useful in characterizing metastatic thyroid carcinoma and in identifying those patients with poorer prognoses. (+info)Case-control study of thyroid cancer in Northern Italy: attributable risk. (5/468)
BACKGROUND: The percentage of thyroid cancer cases attributable to specific risk factors can be calculated to focus preventive strategies. The per cent population attributable risks (PAR) for thyroid cancer were estimated in relation to history of benign thyroid diseases, history of radiotherapy, residence in endemic goitre areas and selected indicators of a poor diet, using data from a case-control study conducted between 1986 and 1992 in Northern Italy. METHODS: Cases were 399 histologically confirmed incident thyroid cancers and controls were 617 patients, admitted to hospital for a wide range of acute, non-neoplastic, non-hormone-related diseases. The PAR were computed on the basis of multivariate odds ratios (OR) and on the distribution of risk exposure among cases, assuming they are representative of the general population of cases. RESULTS: A history of benign thyroid disease accounted for 18.9% of cases, radiotherapy for 1.2%, residence for > or =20 years in endemic goitre areas for 2.4% of cases, and their combination for 21.7% of thyroid cancer cases; selected indicators of a poor diet accounted for 40.9% of thyroid cancer cases in this population. The combination of all factors considered explained over 57% of thyroid cancer cases in both sexes. The estimates for thyroid-related conditions were higher in women than men, whereas the opposite was true for dietary indicators. The overall PAR were somewhat higher in people aged > or =45 years (63.8%) than in younger subjects, and for follicular (69.1%) rather than papillary (53.7%) cancers. CONCLUSIONS: Exposure to a few simply identified and potentially modifiable risk factors or indicators (benign thyroid disease, residence in endemic goitre area and a poor diet) explained about 60% of thyroid cancer cases in this Italian population, indicating the theoretical scope for prevention. (+info)Reproductive and hormonal risk factors for thyroid cancer in Los Angeles County females. (6/468)
We conducted an individually matched case-control study (292 pairs) of female thyroid cancer patients to examine the role of reproductive history and exogenous hormones in this disease. Radiation treatment to the head or neck [28 cases and 2 controls exposed; odds ratio (OR), 14.0; 95% confidence interval (CI), 3.5-121.3] and certain benign thyroid diseases (including adolescent thyroid enlargement, goiter, and nodules or tumors) were strongly associated with thyroid cancer. Irregular menstruation increased risk (OR, 1.8; 95% CI, 0.9-3.7). Age at menarche and pregnancy history were not related to disease. Women with natural menopause and hysterectomized women without oophorectomy had no increase in risk, but disease risk was elevated in women with bilateral oophorectomy (OR, 6.5; 95% CI, 1.1-38.1). In general, use of oral contraceptives and other exogenous estrogens was not associated with thyroid cancer. However, risk increased with number of pregnancies in women using lactation suppressants (P = 0.03) and decreased with duration of breastfeeding (P = 0.04). These data provide only limited support for the hypothesis that reproductive and hormonal exposures are responsible for the marked excess of thyroid cancer risk in adult females. (+info)Non-suppressed thyrotropin and elevated thyroglobulin are independent predictors of recurrence in differentiated thyroid carcinoma. (7/468)
OBJECTIVE: Although in most cases differentiated thyroid carcinoma (DTC) responds to surgery and radioiodine (RaI) therapy, some patients will have recurrence and eventually cancer-related death. However, although various prognostic factors of DTC have been identified (e.g. staging, suppressed thyrotropin), none of the previous studies have assessed simultaneously their role in multivariate analysis. DESIGN AND METHODS: In this retrospective population-based study, we reviewed the clinicopathological data of 254 DTC patients treated in eastern Finland during the years 1976-1995, for clinical characteristics, primary treatment, follow-up and cancer recurrence. Tumor stage was based on pathological tumor-node-metastasis (pTNM) classification, and histopathological specimens were re-evaluated. RESULTS: DTC recurrence occurred in 33 patients (13%). In univariate analyses, the predictors of recurrence were older age (>60 years, P<0.05), follicular tumor type (P<0.01), pTNM classification system (P<0.05) and post-ablative radioiodine uptake outside the neck (P<0.05). Non-suppressed serum thyrotropin (TSH) and elevated serum thyroglobulin (>3 microg/l) measured one year after operation were both related to tumor recurrence (P<0.05 and P<0.001 respectively). In multivariate analysis the independent predictors for recurrence were both elevated thyroglobulin (P<0.001) and non-suppressed TSH (P<0.05) independent of histology, pTNM stage and RaI uptake. Adjusted risk ratio for recurrence of DTC for unsuppressed thyrotropin was 2.3, for elevated thyroglobulin 14.0 and, if both conditions were present, the risk ratio increased to 45.1. CONCLUSION: Our results suggest that both non-suppressed serum TSH and elevated serum thyroglobulin are related to an increased risk of DTC recurrence independent of tumor type and pTNM stage. (+info)Expression of cytokeratin 20 in thyroid carcinomas and peripheral blood detected by reverse transcription polymerase chain reaction. (8/468)
We investigated a nested reverse transcriptase polymerase chain reaction (RT-PCR) system to detect CK20 mRNA in thyroid carcinomas, benign thyroid diseases and peripheral blood to improve diagnosis of thyroid carcinoma and to detect disseminated tumour cells. Frozen tissue samples of 46 thyroid carcinomas and 30 benign thyroid diseases (14 multinodular goiters, 14 follicular adenomas, two Hashimoto's thyroiditis) were obtained intraoperatively. Preoperative blood samples were drawn from 31 patients with thyroid cancer, nine patients with benign thyroid disorders and 20 healthy volunteers. Nine out of nine medullary, 9/12 follicular, 7/19 papillary and 2/6 anaplastic carcinomas expressed CK20 transcripts. CK20 mRNA was undetectable in 30 tissue sections of benign thyroid diseases. Circulating tumour cells were found in the blood of 3/8 patients with medullary carcinoma, 2/8 patients with follicular carcinoma, 2/11 patients with papillary carcinoma and 1/4 patients with an anaplastic carcinoma. Nine blood samples of patients with benign thyroid diseases and 20 healthy volunteers tested negative. For the first time CK20 mRNA could be detected in tissue sections of thyroid carcinomas and peripheral blood samples of patients with thyroid cancer. It was not detectable in benign thyroid diseases. Our results therefore strongly suggest that CK20 RT-PCR assays may improve the diagnosis of thyroid carcinoma and is able to detect circulating tumour cells in peripheral blood of thyroid carcinoma patients. (+info)
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AfHNS guidelines: Follicular thyroid neoplasm/carcinoma - African Head & Neck Society (AfHNS) Clinical Practice Guidelines for...
21 - MEK Inhibitors Reverse cAMP-Mediated Anxiety
Clinical Implication of World Health Organization Classification in Patients with Follicular Thyroid Carcinoma in South Korea:...
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Impact of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) on the Outcomes of Lobectomy |...
Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): Trading Six for a Risky Half Dozen: Reply...
Follicular Carcinoma - Thyroid Cancer - MedHelp
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Papillary and follicular carcinomas | Cancer. Cancer treatment.
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Follicular thyroid carcinoma with skull metastases<...
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Surgery of well-differentiated thyroid carcinoma: the pendulum swings back in the central neck. | Harvard Catalyst Profiles |...
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Genetic Alterations of RET: Possible Implications and Clinical Correlations in Thyroid Carcinogenesis | IntechOpen
PLOS ONE: AZD1480 Blocks Growth and Tumorigenesis of RET- Activated Thyroid Cancer Cell Lines
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Sorafenib for Metastatic Thyroid Cancer - National Cancer Institute
Women who survive breast or thyroid cancer are more likely to develop the other type later. ecancer - News
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Sphingosine-1-Phosphate Receptors | Application of Computational Methods for the Design of BACE-1 Inhibitors
Thyroid - Schema Index
Thyroid Cancers are On the Rise - Hungry For Life
Unusual Thyroid Carcinoma Metastases: a Case Series and Literature Review | SpringerLink
Classification of thyroid neoplasms | Eurocytology
Thyroid disease
Thyroglobulin (TG) levels can be elevated in well-differentiated papillary or follicular adenocarcinoma. It is often used to ... non-cancerous tumor Thyroid cancer Papillary Follicular Medullary Anaplastic Lymphomas and metastasis from elsewhere (rare) ...
Langerhans cell sarcoma
LCS may be associated with other malignancies as well, such as follicular lymphoma, adenocarcinoma, and germ cell tumors. ... Langerhans cell histiocytosis Langerhans cell sarcoma Interdigitating dendritic cell sarcoma/tumor Follicular dendritic cell ...
NK2 homeobox 1
In the thyroid, follicular and parafollicular cells are also positive for TTF-1. For lung cancers, adenocarcinomas are usually ... TTF1 is more than merely a clinical marker of lung adenocarcinoma. It plays an active role in sustaining lung cancer cells in ... This results in mucinous lung adenocarcinoma, a source of poor clinical outcomes for patients. However others have found that ... July 2007). "Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1". Cancer Research. 67 ...
Thyroid neoplasm
Pericytic-like follicular adenoma (e) is characterized by a proliferation of spindle follicular cells concentrically arranged ... Thyroid metastasis from lung adenocarcinoma (a, b). Some metastatic tumor cells (right) are positive for thyroglobulin due to ... Follicular patterned medullary thyroid carcinoma (MTC) (a). In this other follicular patterned MTC (b), there are several ... Nearly 80 percent of thyroid cancer is papillary and about 15 percent is follicular; both types grow slowly and can be cured if ...
Microfold cell
B cells have been implicated in the developmental of M cells, since they are also localized in high numbers in the follicular- ... Similarly, a human lymphoma cell line is also known to undergo transition from adenocarcinoma cells to M cells. Though many ...
Signet ring cell
Neoplastic thyroid gland follicular signet ring cell Signet ring adenocarcinoma cell Signet ring melanoma cell Signet ring ...
Leukotriene B4 receptor 2
The highest levels of Ras mutations are found in adenocarcinoma of the pancreas (90%), colon (50%), and lung (30%) Bos, 1989). ... follicular thyroid adenoma, Renal cell carcinoma, urinary bladder Transitional cell carcinoma, esophagus squamous cell ... The proliferation of Caco-2 human epithelial colorectal adenocarcinoma cells in culture was stimulated by 12-HETE and inhibited ... carcinoma, colon adenocarcinoma, the Serous cystadenocarcinoma type of ovarian cancer, and uterine cervical carcinoma. Other ...
List of MeSH codes (C04)
... adenocarcinoma, clear cell MeSH C04.557.470.200.025.060 - adenocarcinoma, follicular MeSH C04.557.470.200.025.060.225 - ... follicular MeSH C04.557.470.200.025.095 - adenocarcinoma, scirrhous MeSH C04.557.470.200.025.095.410 - linitis plastica MeSH ... carcinoma, papillary, follicular MeSH C04.557.470.200.025.075 - adenocarcinoma, mucinous MeSH C04.557.470.200.025.085 - ... follicular MeSH C04.557.386.480.350.350 - lymphoma, large-cell, follicular MeSH C04.557.386.480.350.525 - lymphoma, mixed-cell ...
International Classification of Diseases for Oncology
M8330/3 Follicular adenocarcinoma, NOS (C73.9) Follicular carcinoma, NOS M8331/3 Follicular adenocarcinoma, well differentiated ... follicular variant (C73.9) Papillary adenocarcinoma, follicular variant Papillary and follicular adenocarcinoma Papillary and ... C73.9) Follicular carcinoma, well differentiated M8332/3 Follicular adenocarcinoma, trabecular (C73.9) Follicular carcinoma, ... follicular/follicle center, NOS M9691/3 Follicular lymphoma, grade 2 Follicular lymphoma, small cleaved cell M9698/3 Follicular ...
List of skin conditions
Primary cutaneous follicular lymphoma (follicular center cell lymphoma, follicular center lymphoma) Primary cutaneous ... Aggressive digital papillary adenocarcinoma (digital papillary adenocarcinoma, papillary adenoma) Apocrine gland carcinoma ... follicular mucinosis, Pinkus' follicular mucinosis-benign primary form) Localized lichen myxedematosus Myxoid cyst (digital ... follicular atrophoderma and basal cell carcinomas) Beare-Stevenson cutis gyrata syndrome Bloom syndrome (Bloom-Torre-Machacek ...
Testicular cancer
... of the testes activin receptor-like kinase-1-negative anaplastic large cell lymphoma of the testes pediatric-type follicular ... Adenoma Carcinoma Tumors of the paratesticular structures Adenomatoid tumor Malignant and benign mesothelioma Adenocarcinoma of ...
List of cancer types
Adenocarcinoma of the lung Bronchial adenomas/carcinoids Small cell lung cancer Mesothelioma Non-small cell lung cancer Non- ... Chronic lymphocytic leukemia Chronic myelogenous leukemia Cutaneous T-cell lymphoma Diffuse large B-cell lymphoma Follicular ... Non-Hodgkin lymphoma Precursor B lymphoblastic leukemia Primary central nervous system lymphoma Primary cutaneous follicular ...
MicroRNA
MiRNAs influence B cell maturation, generation of pre-, marginal zone, follicular, B1, plasma and memory B cells. Another role ... but not in sporadic colonic adenocarcinoma that lack mucinous components. In-vitro studies suggested that miR-205 and miR-373 ...
Tower Cancer Research Foundation
A Phase 2 Trial of Immunotherapy With Mitumprotimut-T (Id-KLH) and GM-CSF Following Rituximab in Follicular B-cell Lymphoma - ... resistant adenocarcinoma of the lung (NSCLA) - Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol ... Bortezomib, bendamustine, and rituximab in patients (pts) with relapsed (rel) or refractory (ref) follicular lymphoma (FL): ... Phase II trial of vatalinib in patients with advanced or metastatic pancreatic adenocarcinoma who failed gemcitabine therapy - ...
HAVCR2
April 2012). "IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin ... Blockade of this receptor can improve the NK cells antitumor activity in esophageal cancer, melanoma and lung adenocarcinoma. ... melanoma and follicular B-cell non-Hodgkin lymphoma. The HAVCR2 pathway may interact with the PD-1 pathway in the dysfunctional ...
Cowden syndrome
The most common malignancies associated with the syndrome are adenocarcinoma of the breast (20%), followed by adenocarcinoma of ... In the setting of thyroid cancer or a follicular adenoma, a total thyroidectomy is recommended even in cases where it appears ... It is estimated that less than 10 percent of individuals with Cowden syndrome may develop follicular thyroid cancer. Cases of ... Thyroid Two thirds of patients have thyroid disorders, and these typically include benign follicular adenomas or multinodular ...
Yuri Nikiforov (scientist)
"Colloid-Rich" follicular neoplasm/suspicious for follicular neoplasm thyroid fine-needle aspiration specimens: Cytologic, ... RET rearrangements in lung adenocarcinoma and radiation. J Thorac Oncol. 2014 Jan;9(1):118-20. Dettmer MS, Perren A, Moch H, ... Highly accurate diagnosis of cancer in thyroid nodules with follicular neoplasm/suspicious for a follicular neoplasm cytology ... PAX8/PPARγ Rearrangement in Thyroid Nodules Predicts Follicular-Pattern Carcinomas, in Particular the Encapsulated Follicular ...
Renal cell carcinoma
It is considered an adenocarcinoma. There are two subtypes: sporadic (that is, non-hereditary) and hereditary. Both such ... Multilocular cystic clear cell renal cell carcinoma Tubulocystic renal cell carcinoma Thyroid-like follicular renal cell ...
ID4
In Non Hodgkin lymphoma, the ID4 promoter region is implicated in follicular lymphomas, diffuse B Cell lymphomas and lymphoid ... The ID4 promoter region is hypermethylated and infrequently expressed in gastric adenocarcinomas and frequently expressed in ... "Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma". Oncogene. 22 (44): 6946-53. doi:10.1038/sj.onc. ... "Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma". Oncogene. 22 (44): 6946-6953. doi:10.1038/sj.onc ...
P110α
"FDA approves new treatment for adults with relapsed follicular lymphoma". US Food and Drug Administration. September 14, 2017. ... "Mutations of PIK3CA in gastric adenocarcinoma". BMC Cancer. 5: 29. doi:10.1186/1471-2407-5-29. PMC 1079799. PMID 15784156. ... got FDA approval for the treatment of adult patients with relapsed follicular lymphoma (FL) who have received at least two ...
HK3
... is found to be overexpressed in malignant follicular thyroid nodules. In conjunction with cyclin A and galectin-3, HK3 ... "Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma". Histology and ... cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules". Clinical Endocrinology. 68 (2): 252-7. doi: ...
Adenoma
Over time adenomas may transform to become malignant, at which point they are called adenocarcinomas. Most adenomas do not ... especially when the cells found at biopsy are of the follicular type. Pituitary adenomas are seen in 10% of neurological ...
CYLD cutaneous syndrome
The term "CYLD cutaneous syndrome" as applied to individuals with MFT1, BSS, or FC hair follicular tumors and carrying a ... These malignant tumors may metastasize to non-cutaneous tissues such as the salivary glands (i.e.basal cell adenocarcinomas of ... Some of these tumors resemble basal-cell carcinomas or adenocarcinomas. ...
CEACAM6
2004). "CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells". ... 50/90-like molecule on follicular keratinocytes". Arch. Dermatol. Res. 289 (8): 457-65. doi:10.1007/s004030050221. PMID 9266023 ...
Precision diagnostics
An extreme example of a group of cancer, Esophageal adenocarcinomas, which are hardly distinguishable by morphology, makes ... Most lymphoma identities may be characterized by chromosome translocations, for example, follicular lymphoma (FL) t(14;18), ... Using cDNA microarrays, the genetic variations of subtypes of oesophageal adenocarcinomas are profiled and the prognosis of ... This is because nearly all oesophageal adenocarcinomas arise from Barrett's mucosa. ...
Vaginal epithelium
Vaginal adenocarcinoma arises from secretory cells in the epithelium Clear cell adenocarcinoma of the vagina arises in response ... During the luteal and follicular phases of the estrous cycle the structure of the vaginal epithelium varies. The number of cell ...
Endometrium
Endometrioid adenocarcinoma from biopsy. H&E stain. Micrograph of decidualized endometrium due to exogenous progesterone. H&E ... Proliferation is induced by estrogen (follicular phase of menstrual cycle), and later changes in this layer are engendered by ... Baerwald, A. R.; Pierson, R. A. (2004). "Endometrial development in association with ovarian follicular waves during the ...
Glycodelin
In women, the levels in follicular fluid exceed those of non-pregnant women. ·Seminal plasma: PP-14 is a significant protein ... in endometrial adenocarcinoma and effect of medroxyprogesterone acetate". British Journal of Obstetrics and Gynaecology. 95 (12 ... Is secreted by granulosa cells into the follicular fluid. Glycodelin-F reduces the blinding of spermatozoa to the zona ... First, cumulus cells reduce the spermatozoa-zona binding inhibitory activity of follicular fluid probably by taking up and ...
Index of oncology articles
... follicular large cell lymphoma - follicular mixed cell lymphoma - follicular thyroid cancer - formaldehyde - FR901228 - ... clear cell adenocarcinoma - clear-cell sarcoma - clear cell sarcoma of the kidney - clinical breast exam - clinical resistance ... thyroid follicular cell - thyroid hormone - thyroid-stimulating hormone - thyroidectomy - thyrotropin alfa - tiazofurin - time ... adenocarcinoma - adenoid cystic cancer - adenoma - adenopathy - adenosine triphosphate - adenovirus - adjunct agent - ...
Thymidine kinase in clinical chemistry
"Deoxythymidine kinase in the staging of prostatic adenocarcinoma". The Prostate. 29 (1): 15-9. doi:10.1002/(SICI)1097-0045( ... "High baseline serum thymidine kinase 1 level predicts unfavorable outcome in patients with follicular lymphoma". Leukemia & ...
List of OMIM disorder codes
EGFR Adenocarcinoma of lung, somatic; 211980; BRAF Adenocarcinoma of lung, somatic; 211980; ERBB2 Adenocarcinoma of lung, ... follicular; 188470; MINPP1 Thyroid carcinoma, follicular; 188470; NRAS Thyroid carcinoma, papillary; 188550; GOLGA5 Thyroid ... somatic; 211980; PRKN Adenocarcinoma, ovarian, somatic; 604370; PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, ... ACADS Adenocarcinoma of lung, response to tyrosine kinase inhibitor in; 211980; ...
Hormone replacement therapy
Menopause is the permanent cessation of menstruation resulting from loss of ovarian follicular activity, defined as beginning ... decreased risk of cervical squamous cell cancer in post menopausal women treated with HRT and a weak increase in adenocarcinoma ...
Pharmacodynamics of estradiol
However, in women, a sharp increase in estradiol levels to about 200 to 500 pg/mL occurs at the end of the follicular phase ( ... "Endocrine effects of oestrogen withdrawal in long-term treated patients with prostatic adenocarcinoma". Eur. Urol. 14 (1): 6-8 ...
Metastasis
Research comparing gene expression between primary and metastatic adenocarcinomas identified a subset of genes whose expression ... such as renal cell carcinoma originating in the kidney and follicular carcinomas of the thyroid. Because of their thinner walls ... adenocarcinoma)-lower two-thirds of image). H&E stain. Metastatic cancer in the lungs Metastases from the lungs to the brain ... the expression of these metastatic-associated genes was shown to apply to other cancer types in addition to adenocarcinoma. ...
Regulatory T cell
This trend is seen in cancers such as colorectal carcinoma and follicular lymphoma. This could be due to Treg cells' ability to ... "Association of Foxp3 rs3761548 polymorphism with cytokines concentration in gastric adenocarcinoma patients". Cytokine. 138: ...
Patrizia Paterlini-Bréchot
De Pasquale, P. Paterlini, A. Di Francesco, L. Vecchio, D. Quaglino : Follicular lymphomas with predominant splenic involvement ... Detection of circulating prostate-derived cells in patients with prostate adenocarcinoma through an optimized RT-PCR procedure ...
Ovarian cancer
Mucinous tumors include mucinous adenocarcinoma and mucinous cystadenocarcinoma. Mucinous adenocarcinomas make up 5-10% of ... including ovarian follicular cyst, leiomyoma, endometriosis, ectopic pregnancy, hydrosalpinx, tuboovarian abscess, ovarian ... Clear-cell adenocarcinomas are histopathologically similar to other clear cell carcinomas, with clear cells and hobnail cells. ... Advanced mucinous adenocarcinomas have a poor prognosis, generally worse than serous tumors, and are often resistant to ...
Table - Trichodysplasia Spinulosa Polyomavirus Endothelial Infection, California, USA - Volume 28, Number 9-September 2022 -...
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IJERPH | Free Full-Text | Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive...
... oxyphilic adenocarcinoma = 8290, follicular adenocarcinoma NOS = 8330, papillary carcinoma follicular variant = 8340, papillary ... Yu, X.-M.; Schneider, D.F.; Leverson, G.; Chen, H.; Sippel, R.S. Follicular Variant of Papillary Thyroid Carcinoma is a Unique ... Histology is based on International Classification of Diseases for Oncology (ICD-O-3) coding: Papillary adenocarcinoma NOS = ...
Lymph Node Infarctions a Likely Sign of Malignancy
All 5 cases were hematologic malignancies, either DLBCL or follicular lymphoma. Three of the 30 (10%) cases were later ... The other 4 malignancies were pancreatic adenocarcinoma, squamous cell carcinoma, melanoma, and seminoma. ... diagnosed with hematologic malignancies (DLBCL, follicular lymphoma, anaplastic large cell lymphoma). Of the 4 patients with no ...
Imbruvica (ibrutinib) dosing, indications, interactions, adverse effects, and more
BIRC5 Modulates PD-L1 Expression and Immune Infiltration in Lung Adenocarcinoma
CD4⁺ follicular helper T cell infiltration predicts breast cancer survival. J CLIN INVEST. 2013;123:2873-92 ... BIRC5 Modulates PD-L1 Expression and Immune Infiltration in Lung Adenocarcinoma Teng Ma*, Jie Gu*, Haoyu Wen*, Fengkai Xu , Di ... Ma T, Gu J, Wen H, Xu F, Ge D. BIRC5 Modulates PD-L1 Expression and Immune Infiltration in Lung Adenocarcinoma. J Cancer 2022; ... Ma T, Gu J, Wen H, Xu F, Ge D. BIRC5 Modulates PD-L1 Expression and Immune Infiltration in Lung Adenocarcinoma. J Cancer 2022; ...
Science.NaturalNews.com - Conduct powerful scientific research in mere seconds for your book, blog, website article or news...
result sql = Follicular adenocarcinoma. Follicular adenocarcinoma 17. char = l;code = 108. char = y;code = 121. char = m;code ... start str = Papillary adenocarcinoma. sql str = Papillary adenocarcinoma. start str = salivary glands. sql str = salivary ... See more studies on Papillary adenocarcinoma and.... How is this determined? The order of these related concepts is determined ...
Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas | Semantic Scholar
We examined 32 primary pancreatic adenocarcinomas for CDKN2 mutations and for loss of heterozygosity of 9p21 sequences to ... plays an important role during tumorigenesis or tumor progression in a significant proportion of pancreatic adenocarcinomas. ... plays an important role during tumorigenesis or tumor progression in a significant proportion of pancreatic adenocarcinomas. ... and loss of 9p sequences suggests a role for a tumor suppressor gene in the development of follicular and anaplastic thyroid ...
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Bio2Vec
These highlights do not include all the information needed to use ESZOPICLONE safely and effectively. See full prescribing...
Selective activation of ras oncogenes in follicular and undifferentiated thyroid carcinomas<...
Follicular Adenocarcinoma Medicine & Life Sciences 100% * ras Genes Medicine & Life Sciences 85% ... Selective activation of ras oncogenes in follicular and undifferentiated thyroid carcinomas. G. Manenti, S. Pilotti, F. C. Re, ... In our cases, mutations in all three ras oncogenes were found in follicular carcinomas (five out of 21) and in the less ... Manenti, G, Pilotti, S, Re, FC, Della Porta, G & Pierotti, MA 1994, Selective activation of ras oncogenes in follicular and ...
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DeCS
Adenocarcinomas, Follicular Carcinoma, Follicular Thyroid Carcinomas, Follicular Thyroid Follicular Adenocarcinoma Follicular ... Carcinomas, Follicular Thyroid. Follicular Adenocarcinoma. Follicular Adenocarcinomas. Follicular Thyroid Carcinoma. Follicular ... Follicular Thyroid Carcinoma Follicular Thyroid Carcinomas Thyroid Carcinoma, Follicular Thyroid Carcinomas, Follicular ... Adenocarcinoma, Follicular - Preferred Concept UI. M0027492. Scope note. An adenocarcinoma of the thyroid gland, in which the ...
Code System Concept
Biomarkers of human health
Yu L, Todd NW, Xing L, Xie Y, Zhang H. Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers. Int J ... Thyroglobulin (Tg): It is used in diagnosis and prognosis of papillary and follicular thyroid cancer. Tg can be measured in ... is very helpful in early detection of prostate adenocarcinoma. ...
Cancer-associated fibroblasts-derived gamma-glutamyltransferase 5 promotes tumor growth and drug resistance in lung...
In this study, we found that gene GGT5 was highly expressed in cancer-associated fibroblasts (CAFs) in lung adenocarcinoma, ... predicting the unfavorable survival of patients with lung adenocarcinoma. Cell growth, foci formation and spheres formation ... indicating that GGT5 may be a promising therapeutic target in lung adenocarcinoma. ... One recent study showed that GGT5 highly expressed in follicular dendritic cells promoting B cell confinement to germinal ...
Table - Trichodysplasia Spinulosa Polyomavirus Endothelial Infection, California, USA - Volume 28, Number 9-September 2022 -...
Bacterial Tracheitis Article
Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma | eLife
... causes invasive multilayering of the follicular epithelia. Analyzing the integrated Lgl-KD and wildtype transcriptomes, we ... In lung adenocarcinoma (LUAD), OS was based on 672 patients and FP on 443 patients. In lung squamous carcinoma (LUSC), OS was ... We describe human COX6B2, a component of cytochrome c oxidase (complex IV). COX6B2 is expressed in human lung adenocarcinoma ( ... COX6B2 is expressed in human lung adenocarcinoma (LUAD) tumors and correlates with poor survival. Using a large-scale ...
SMALL MOLECULE INHIBITORS OF APEX, ALONE AND IN COMBINATION WITH OTHER CANCER DRUGS TO INHIBIT GROWTH OF CANCER CELLS - DANA...
The method of claim 12, wherein the cancer is esophageal adenocarcinoma. 15. The method of claim 1 or 2, wherein the ... follicular lymphoma (FL), mantle cell lymphoma (MCL) and ALK+ anaplastic large cell lymphoma (e.g., B-cell non-Hodgkins ... 00112] In certain embodiments, the methods may be useful in the treatment of esophageal adenocarcinoma. ... metastatic pancreatic adenocarcinoma, refractory B-cell non-Hodgkins lymphoma, and relapsed B-cell non-Hodgkins lymphoma, ...
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Pesquisa | Portal Regional da BVS
... adenocarcinoma of the small/large intestine; follicular cell adenoma of the thyroid; fibroma of the subcutis, and malignant ... Adenocarcinoma , Adenoma , Humanos , Camundongos , Ratos , Animais , Masculino , Feminino , Ratos Endogâmicos F344 , ... Furthermore, the incidence of primary lung tumors, such as adenomas and adenocarcinomas, was 65.4, 62.5, and 45.4% in the FVB- ... In females, significantly increased tumors were adenocarcinoma and fibroadenoma of the mammary gland, squamous cell papilloma ...
Follicular neoplasms: The role for observation, fine needle aspiration biopsy, thyroid suppression, and surgery<...
keywords = "Adenoma, Carcinoma, Differential diagnosis, Follicular adenocarcinoma, Frozen sections, Levothyroxine, Needle ... Follicular neoplasms: The role for observation, fine needle aspiration biopsy, thyroid suppression, and surgery. Seminars in ... Louis, J. D. S. T., Leicht, G. S., & Tyler, D. (1999). Follicular neoplasms: The role for observation, fine needle aspiration ... Follicular neoplasms : The role for observation, fine needle aspiration biopsy, thyroid suppression, and surgery. In: Seminars ...
Organization | Ohio State University
Week 135: Case 1 | Johns Hopkins Surgical Pathology Unknown Conference
Clear cell adenocarcinoma of the lung * Metastatic thyroid carcinoma, follicular variant * Metastatic clear cell carcinoma of ... Discussion: Clear cell carcinomas of the lung may be either squamous cell carcinoma or adenocarcinoma. One would expect a ... Discussion: Clear cell carcinomas of the lung may be either squamous cell carcinoma or adenocarcinoma. One would expect a ... primary pulmonary adenocarcinoma, in most cases, to demonstrate TTF-1 immunoreactivity. A metastatic well-differentiated ...
Zoloft (Sertraline) for Depression, Side Effects, Dosage, Interactions & Warnings
follicular
... adenocarcinoma - follicular carcinoma of thyroid gland … Medical dictionary. *. follicular carcinoma of thyroid ... Follicular Unit Extraction - (FUE) is a technique of hair restoration that involves, direct extraction of the follicular units ... Follicular lymphoma - Classification and external resources Follicular lymphoma replacing a lymph node ICD 10 C … Wikipedia ... Follicular thyroid cancer - Classification and external resources Gross pathological section of a follicular thyroid adenoma ( ...
Papillary8
- See more studies on Papillary adenocarcinoma and. (naturalnews.com)
- Thyroid cancer can be mainly classified as papillary adenocarcinoma and follicular adenocarcinoma according to their pathological characteristics. (moderncancerhospital.com.cn)
- Though different morphologies have been reported, the most frequent histological type of feline endometrial adenocarcinoma (FEA) is the papillary serous. (biomedcentral.com)
- PeaceHealth offers care for different thyroid cancer (papillary, follicular and Hṻrthle cell), medullary, anaplastic and others. (peacehealth.org)
- Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): Implications for the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). (rush.edu)
- Included Diagnoses: Papillary, Follicular, Medullary and other carcinomas (including all subtypes), Adenocarcinoma (including all subtypes), Squamous Cell Carcinoma (including all subtypes), Neuroendocrine tumors of the thyroid (including all subtypes). (accegen.com)
- Differentiated thyroid cancers include papillary, follicular carcinomas and are usually associated with a good prognosis. (endocrine-abstracts.org)
- Perhaps the most useful application is the identification of Thyroid Carcinoma of the papillary type, although Follicular Carcinoma is also labeled by this antibody approximately 50-60% of the time. (affordableihcinstruments.com)
Lymphoma6
- All 5 cases were hematologic malignancies, either DLBCL or follicular lymphoma. (medscape.com)
- Three of the 30 (10%) cases were later diagnosed with hematologic malignancies (DLBCL, follicular lymphoma, anaplastic large cell lymphoma). (medscape.com)
- Follicular large cell lymphoma - is a rare type of non Hodgkin lymphoma (cancer of the lymphatic system) with large cells that look cleaved (split) or non cleaved under the microscope. (en-academic.com)
- Six-year follow-up data showed an overall survival rate of 89% among patients with follicular lymphoma who received either lenalidomide plus rituximab or immunochemotherapy. (oncnursingnews.com)
- Lenalidomide (Revlimid) plus rituximab (Rituxan) for the frontline treatment of advanced follicular lymphoma (FL) demonstrated a similar efficacy and safety profile to rituximab plus chemotherapy (R-chemo) in a 6-year analysis of the RELEVANCE trial (NCT01650701), according to findings published in the Journal of Clinical Oncology . (oncnursingnews.com)
- That's the day it was staged and named, Non-Hodgkin's Follicular Lymphoma. (lightthenight.org)
Carcinoma7
- Lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) are two main pathological types of NSCLC. (aging-us.com)
- The diagnosis and management of follicular carcinoma of the thyroid gland remains a controversial topic. (utmb.edu)
- The extent of surgical excision of follicular carcinoma also raises several competing views. (utmb.edu)
- Discussion: Clear cell carcinomas of the lung may be either squamous cell carcinoma or adenocarcinoma. (jhu.edu)
- CAV1 expression was lower in lung adenocarcinoma and lung squamous cell carcinoma than in control tissues. (rarediseaseadvisor.com)
- The researchers also found a positive correlation between CAV1 expression and immune infiltration of cancer-associated fibroblasts, endothelial, and neutrophils in lung adenocarcinoma and lung squamous cell carcinoma. (rarediseaseadvisor.com)
- TEK expression levels were also lower in lung adenocarcinoma and lung squamous cell carcinoma tissues when compared to control tissues. (rarediseaseadvisor.com)
Lung13
- Ma T, Gu J, Wen H, Xu F, Ge D. BIRC5 Modulates PD-L1 Expression and Immune Infiltration in Lung Adenocarcinoma. (jcancer.org)
- Lung adenocarcinoma (LUAD) is the most prevalent thoracic cancer with the highest incidence and mortality worldwide. (jcancer.org)
- BIRC5 promotes lung adenocarcinoma progression by modulating PD-L1 expression and inducing tumor immune evasion. (jcancer.org)
- In this study, we found that gene GGT5 was highly expressed in cancer-associated fibroblasts (CAFs) in lung adenocarcinoma, predicting the unfavorable survival of patients with lung adenocarcinoma. (aging-us.com)
- Taken together, our study illuminates that high level of GGT5 in CAFs contributes to cancer cell survival and drug resistance, indicating that GGT5 may be a promising therapeutic target in lung adenocarcinoma. (aging-us.com)
- COX6B2 is expressed in human lung adenocarcinoma (LUAD) and expression correlates with reduced survival time. (elifesciences.org)
- Positive Control: Adenocarcinoma of the Lung or Thyroid for TTF-1. (scytek.com)
- Specificity: This antibody reacts with TTF-1 protein found in adenocarcinomas of the lung and tumors originating in the thyroid. (scytek.com)
- In lung cancers, Adenocarcinomas are usually positive, while Squamous Cell Carcinomas and Large Cell Carcinomas are rarely positive. (scytek.com)
- This Multiplex cocktail of TTF-1 and Cytokeratin 5 produces two-color high contrast staining for differentiating primary adenocarcinoma of the Lung from Metastatic Carcinomas of the breast and Malignant Mesothelioma. (scytek.com)
- recently investigated the roles of these cells in the setting of lung adenocarcinoma (LUAD), and their results were published in Cell. (acir.org)
- 75% of lung non-small cell carcinomas (NSCLCs) are positive, adenocarcinomas (ACs) are significantly higher than squamous cell carcinomas (SCC), more than 90% of primary small cell lung cancers (SCLC) are positive, and TTF-1 is positive in non-small cell lung cancers (SCLC). (medicaltrend.org)
- Zheng M , Zhou H , Xie J , Zhang H , Shen X , Zhu D . Molecular typing and prognostic model of lung adenocarcinoma based on cuprotosis-related lncRNAs. (wjgnet.com)
Experienced adenocarcinomas of the colon1
- Of note, among these patients, 1 experienced chronic obstructive pulmonary disease and 2 experienced adenocarcinomas of the colon. (oncnursingnews.com)
Neoplasms1
- The goal of this review is to address these issues and present an algorithm for the management of follicular neoplasms of the thyroid. (utmb.edu)
Anaplastic1
- The authors' data suggest that alterations in CDKN2 played a role in a minority of thyroid cancers (three of 35), and loss of 9p sequences suggests a role for a tumor suppressor gene in the development of follicular and anaplastic thyroid cancers. (semanticscholar.org)
Tumor5
- Mxi1 tumor suppressor gene is not mutated in primary pancreatic adenocarcinoma. (semanticscholar.org)
- Follicular thyroid cancer - Classification and external resources Gross pathological section of a follicular thyroid adenoma (tumor at the bottom). (en-academic.com)
- As a crucial step towards clinical application, we investigated tumor specificity and transfection efficiency of epidermal growth factor receptor (EGFR)-targeted polyplexes as systemic NIS gene delivery vehicles in an advanced genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC) that closely reflects human disease. (oncotarget.com)
- The biological and clinical behavior is very unpredictable especially if it s associated with another tumor, like adenocarcinoma. (endocrine-abstracts.org)
- Within the ovary, angiogenesis is not only integral to follicular development and the formation of the corpus luteum, but it is also a hallmark of tumorigenesis and tumor progression in ovarian cancers. (unh.edu)
Tumors1
- We treat adenocarcinomas and other types of tumors, such as carcinoid tumors, gastrointestinal stromal tumors (GSITs), lymphomas and sarcomas. (peacehealth.org)
Endometrial adenocarcinoma1
- Another cancer hit, endometrial adenocarcinoma on November 18, 2016, almost exactly one year from diagnosis #1. (lightthenight.org)
20171
- 2017 (www.who.int/publications/m/item/guidance-for-the-de- (www.who.int/publications/m/item/guidance-for-the-development- velopment-of-evidence-based-vaccine-related-recommenda- of-evidence-based-vaccine-related-recommendations, consulté en tions, accessed August 2022). (who.int)
Ovarian3
- Follicular atresia - is the break down of the ovarian follicles. (en-academic.com)
- Therefore, the overall objective of the present study was to identify potential regulators of CCN1 and their mechanisms of action in the ovarian adenocarcinoma cell line, OVCAR-8. (unh.edu)
- Several conditions, including polycystic ovarian syndrome, can affect the follicular antra by keeping the ovarian follicles from growing and maturing. (conhecoumlugar.com)
Pulmonary adenocarcinoma1
- One would expect a primary pulmonary adenocarcinoma, in most cases, to demonstrate TTF-1 immunoreactivity. (jhu.edu)
Ductal1
- The p16-Leiden deletion was associated with progression toward conventional ductal adenocarcinomas in all cases but one and might also indicate that chemoprevention needs consideration. (semanticscholar.org)
Malignancies1
- It is specifically found in the periderm, the transientlysuperficial layer that envelopes the developing epidermis.Anti-Cytokeratin 19 reacts with a wide variety of epithelium and epithelial malignancies including Adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver and breast. (affordableihcinstruments.com)
Dendritic1
- Follicular dendritic cells - (FDC) are cells of the immune system found in lymph follicles. (en-academic.com)
Helper2
- In contrast, they observed a negative correlation between CAV1 expression and immune infiltration of T cell follicular helper. (rarediseaseadvisor.com)
- CD8 + T cells are often the focus of research in cancer immunotherapy, but recent evidence has suggested that CD4 + T helper cells (particularly T follicular helper [TFH] cells) and B cells (particularly germinal center [GC] B cells) may also play important behind-the-scenes roles in supporting CD8 + T cells and antitumor immune responses. (acir.org)
Mutations2
- We examined 32 primary pancreatic adenocarcinomas for CDKN2 mutations and for loss of heterozygosity of 9p21 sequences to assess the role of CDKN2 in pancreatic carcinogenesis. (semanticscholar.org)
- In our cases, mutations in all three ras oncogenes were found in follicular carcinomas (five out of 21) and in the less differentiated thyroid tumour: poorly differentiated carcinomas (three out of 11) and undifferentiated carcinomas (one out of five). (elsevier.com)
Cells2
- An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (bvsalud.org)
- In the thyroid, follicular and parafollicular cells are positive. (scytek.com)
Cancer3
- Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell lines than in primary pancreatic adenocarcinomas. (semanticscholar.org)
- 14. The method of claim 12, wherein the cancer is esophageal adenocarcinoma. (sumobrain.com)
- Fine needle aspiration, although very sensitive with other types of thyroid cancer, has limited accuracy with follicular lesions. (utmb.edu)
Patients1
- Le protocole utilisé dans le traitement du myélome multiple a été le VMCD-REV à 76,92% avec pour réponse thérapeutique complète chez 6 patients, 3 réponses partielles et 4 en cours de traitement. (bvsalud.org)
Type1
- Endometrial adenocarcinomas are a rare type of tumour in cats. (biomedcentral.com)
Status1
- Feline endometrial adenocarcinomas maintained the CK7+/CK20+ status of normal endometrium. (biomedcentral.com)
Unit2
- Follicular unit transplantation - is a modern hair restoration technique where the hair is transplanted in groups of 1 4 hairs - exactly as it grows in nature. (en-academic.com)
- Follicular Unit Extraction - (FUE) is a technique of hair restoration that involves, direct extraction of the follicular units from a patient's donor area using a small instrument called a trephine. (en-academic.com)
Large1
- Avant leur mise en forme a large group of external subject-matter définitive, elles sont examinées par un large experts and end-users. (who.int)
Case1
- An unusual case of noninvasive adenocarcinoma arising in a localized adenomyoma of the gallbladder and review of literature. (rush.edu)