Adenocarcinoma, Follicular: An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)Adenocarcinoma: A malignant epithelial tumor with a glandular organization.IndiaExpert Systems: Computer programs based on knowledge developed from consultation with experts on a problem, and the processing and/or formalizing of this knowledge using these programs in such a manner that the problems may be solved.Oral Hemorrhage: Bleeding from the blood vessels of the mouth, which may occur as a result of injuries to the mouth, accidents in oral surgery, or diseases of the gums.Dental Deposits: Accumulations of microflora that lead to pathological plaque and calculus which cause PERIODONTAL DISEASES. It can be considered a type of BIOFILMS. It is subtly distinguished from the protective DENTAL PELLICLE.Toothache: Pain in the adjacent areas of the teeth.Expert Testimony: Presentation of pertinent data by one with special skill or knowledge representing mastery of a particular subject.Health Education, Dental: Education which increases the awareness and favorably influences the attitudes and knowledge relating to the improvement of dental health on a personal or community basis.Duty to Warn: A health professional's obligation to breach patient CONFIDENTIALITY to warn third parties of the danger of their being assaulted or of contracting a serious infection.Adenocarcinoma, Follicular: An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Expert Systems: Computer programs based on knowledge developed from consultation with experts on a problem, and the processing and/or formalizing of this knowledge using these programs in such a manner that the problems may be solved.Expert Testimony: Presentation of pertinent data by one with special skill or knowledge representing mastery of a particular subject.IndiaDuty to Warn: A health professional's obligation to breach patient CONFIDENTIALITY to warn third parties of the danger of their being assaulted or of contracting a serious infection.Diagnosis, Computer-Assisted: Application of computer programs designed to assist the physician in solving a diagnostic problem.Hospitals, Teaching: Hospitals engaged in educational and research programs, as well as providing medical care to the patients.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Natural Cytotoxicity Triggering Receptor 1: A 46-kD stimulatory receptor found on resting and activated NATURAL KILLER CELLS. It has specificity for VIRAL HEMAGGLUTININS that are expressed on infected cells.Radiation Oncology: A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.Health Physics: The science concerned with problems of radiation protection relevant to reducing or preventing radiation exposure, and the effects of ionizing radiation on humans and their environment.Cellular Phone: Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.Medical Oncology: A subspecialty of internal medicine concerned with the study of neoplasms.Radiation Injuries: Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES.Radiotherapy: The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.Cancer Care Facilities: Institutions specializing in the care of cancer patients.Radiobiology: Study of the scientific principles, mechanisms, and effects of the interaction of ionizing radiation with living matter. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Radiotherapy, Computer-Assisted: Computer systems or programs used in accurate computations for providing radiation dosage treatment to patients.Radiotherapy Dosage: The total amount of radiation absorbed by tissues as a result of radiotherapy.Hematology: A subspecialty of internal medicine concerned with morphology, physiology, and pathology of the blood and blood-forming tissues.Cellular Phone: Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.Medical Oncology: A subspecialty of internal medicine concerned with the study of neoplasms.Oncology Nursing: A nursing specialty concerned with the care provided to cancer patients. It includes aspects of family functioning through education of both patient and family.Nigeria: A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja.Hematologic Tests: Tests used in the analysis of the hemic system.Oncology Service, Hospital: The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cancer patient.Practice Management, Medical: The organization and operation of the business aspects of a physician's practice.Radiation Oncology: A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.Family Practice: A medical specialty concerned with the provision of continuing, comprehensive primary health care for the entire family.New York CityBuddhism: The teaching ascribed to Gautama Buddha (ca. 483 B.C.) holding that suffering is inherent in life and that one can escape it into nirvana by mental and moral self-purification. (Webster, 3d ed)Parakeets: Common name for one of five species of small PARROTS, containing long tails.Prince Edward Island: An island in the Gulf of St. Lawrence constituting a province of Canada in the eastern part of the country. It is very irregular in shape with many deep inlets. Its capital is Charlottetown. Discovered by the French in 1534 and originally named Ile Saint-Jean, it was renamed in 1799 in honor of Prince Edward, fourth son of George III and future father of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p981 & Room, Brewer's Dictionary of Names, 1992, p433)Seals, Earless: The family Phocidae, suborder PINNIPEDIA, order CARNIVORA, comprising the true seals. They lack external ears and are unable to use their hind flippers to walk. It includes over 18 species including the harp seal, probably the best known seal species in the world.Dermatology: A medical specialty concerned with the skin, its structure, functions, diseases, and treatment.Cellular Phone: Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.Heart Valve Prosthesis Implantation: Surgical insertion of synthetic material to repair injured or diseased heart valves.Skin DiseasesHeart Valve Prosthesis: A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.Adenocarcinoma, Follicular: An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.PiperidonesCarcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Thyroidectomy: Surgical removal of the thyroid gland. (Dorland, 28th ed)Carcinoma, Papillary, Follicular: A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)Thyroid Gland: A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.Carcinoma, Medullary: A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)Datura stramonium: A plant species of the genus DATURA, family SOLANACEAE, that contains TROPANES and other SOLANACEOUS ALKALOIDS.Burning Mouth Syndrome: A group of painful oral symptoms associated with a burning or similar sensation. There is usually a significant organic component with a degree of functional overlay; it is not limited to the psychophysiologic group of disorders.Pruritus Vulvae: Intense itching of the external female genitals.Diagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Voice: The sounds produced by humans by the passage of air through the LARYNX and over the VOCAL CORDS, and then modified by the resonance organs, the NASOPHARYNX, and the MOUTH.Voice Disorders: Pathological processes that affect voice production, usually involving VOCAL CORDS and the LARYNGEAL MUCOSA. Voice disorders can be caused by organic (anatomical), or functional (emotional or psychological) factors leading to DYSPHONIA; APHONIA; and defects in VOICE QUALITY, loudness, and pitch.Sensation: The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM.Cellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.Ear: The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.Ear, Inner: The essential part of the hearing organ consists of two labyrinthine compartments: the bony labyrinthine and the membranous labyrinth. The bony labyrinth is a complex of three interconnecting cavities or spaces (COCHLEA; VESTIBULAR LABYRINTH; and SEMICIRCULAR CANALS) in the TEMPORAL BONE. Within the bony labyrinth lies the membranous labyrinth which is a complex of sacs and tubules (COCHLEAR DUCT; SACCULE AND UTRICLE; and SEMICIRCULAR DUCTS) forming a continuous space enclosed by EPITHELIUM and connective tissue. These spaces are filled with LABYRINTHINE FLUIDS of various compositions.Ear, Middle: The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.Diagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Cellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.Light: That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Breast Diseases: Pathological processes of the BREAST.Palpation: Application of fingers with light pressure to the surface of the body to determine consistence of parts beneath in physical diagnosis; includes palpation for determining the outlines of organs.Dark Adaptation: Adjustment of the eyes under conditions of low light. The sensitivity of the eye to light is increased during dark adaptation.Skin DiseasesHerpesvirus 4, Human: The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Epstein-Barr Virus Infections: Infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).Epstein-Barr Virus Nuclear Antigens: Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. At least six nuclear antigens have been identified.Stomach Neoplasms: Tumors or cancer of the STOMACH.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Viral Matrix Proteins: Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.Fibrous Dysplasia, Polyostotic: FIBROUS DYSPLASIA OF BONE affecting several bones. When melanotic pigmentation (CAFE-AU-LAIT SPOTS) and multiple endocrine hyperfunction are additionally associated it is referred to as Albright syndrome.Fibrous Dysplasia of Bone: A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).Cafe-au-Lait Spots: Light brown pigmented macules associated with NEUROFIBROMATOSIS and Albright's syndrome (see FIBROUS DYSPLASIA, POLYOSTOTIC).Puberty, Precocious: Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE.GTP-Binding Protein alpha Subunits, Gs: A family of heterotrimeric GTP-binding protein alpha subunits that activate ADENYLYL CYCLASES.Fibrous Dysplasia, Monostotic: FIBROUS DYSPLASIA OF BONE involving only one bone.Gigantism: The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.Testolactone: An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.Facial Bones: The facial skeleton, consisting of bones situated between the cranial base and the mandibular region. While some consider the facial bones to comprise the hyoid (HYOID BONE), palatine (HARD PALATE), and zygomatic (ZYGOMA) bones, MANDIBLE, and MAXILLA, others include also the lacrimal and nasal bones, inferior nasal concha, and vomer but exclude the hyoid bone. (Jablonski, Dictionary of Dentistry, 1992, p113)Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)Neck Pain: Discomfort or more intense forms of pain that are localized to the cervical region. This term generally refers to pain in the posterior or lateral regions of the neck.Diagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Hypesthesia: Absent or reduced sensitivity to cutaneous stimulation.Cellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Neck: The part of a human or animal body connecting the HEAD to the rest of the body.Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Pelvic Pain: Pain in the pelvic region of genital and non-genital origin and of organic or psychogenic etiology. Frequent causes of pain are distension or contraction of hollow viscera, rapid stretching of the capsule of a solid organ, chemical irritation, tissue ischemia, and neuritis secondary to inflammatory, neoplastic, or fibrotic processes in adjacent organs. (Kase, Weingold & Gershenson: Principles and Practice of Clinical Gynecology, 2d ed, pp479-508)Arm: The superior part of the upper extremity between the SHOULDER and the ELBOW.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Diagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Respiration Disorders: Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available.Cellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.Respiratory Tract DiseasesRespiratory Sounds: Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Salivary Glands: Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).Hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (PITUITARY GLAND, ANTERIOR) resulting in hypersecretion of ADENOHYPOPHYSEAL HORMONES such as GROWTH HORMONE; PROLACTIN; THYROTROPIN; LUTEINIZING HORMONE; FOLLICLE STIMULATING HORMONE ; and ADRENOCORTICOTROPIC HORMONE. Hyperpituitarism usually is caused by a functional ADENOMA.Oxidoreductases Acting on CH-NH Group Donors: Enzymes catalyzing the dehydrogenation of secondary amines, introducing a C=N double bond as the primary reaction. In some cases this is later hydrolyzed.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Hydroxyethyl Starch Derivatives: Starches that have been chemically modified so that a percentage of OH groups are substituted with 2-hydroxyethyl ether groups.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
(1/468) A new rapid technique for the fixation of thyroid gland surgical specimens.

One of the main diagnostic problems in thyroid pathology is to distinguish between follicular adenoma and follicular carcinoma. Thorough sampling of the nodule's capsule is recommended in order to identify capsular invasion. However, during the hardening of the tissue, by the usual fixatives the capsule shrinks and rolls downwards and sometimes the capsule separates from the remaining tissue. The present work evaluates the use of "Lymph Node Revealing Solution" (LNRS) for the rapid fixation (2h) of different thyroid lesions as compared to that of formalin. Fifty-one unselected consecutive cases of thyroid nodules, which included various benign and malignant lesions, were examined. Each specimen was cut in two equal parts; one was fixed in LNRS, the other in formalin. Fixation in LNRS for 2 hours gave adequate results in sectioning and staining of the tissue, and excellent immunostains. Its advantage over formalin is the conservation of the natural relationship between the capsule and the rest of the tissue, on the same plane, as well as the short time required for the final diagnosis.  (+info)

(2/468) Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine.

The modifying effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a mutagenic by-product in chlorinated water, on the development of glandular stomach cancers were investigated in Wistar rats. A total of 120 males, 6 weeks of age, were divided into six groups. After initiation with 100 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) solution and 5% NaCl diet for 8 weeks, 30 rats each in groups 1-3 were given MX in the drinking water at concentrations of 30, 10, or 0 ppm for the following 57 weeks. Ten animals each in groups 4-6 were administered the MX without prior carcinogen exposure. There were no statistical significant differences in final body weights between the groups. The incidences and multiplicities of adenocarcinomas in the glandular stomachs were significantly higher (P < 0.05) in the initiated 30 ppm MX group than those in the MNNG/NaCl group. The incidences of atypical hyperplasias in the glandular stomachs were also significantly increased (P < 0.05 or 0.01) by the MX treatments. With their multiplicity, the effects were clearly dose dependent. Interestingly, the 30 ppm MX alone itself induced atypical hyperplasias in the pylorus, although the incidences and severity were low. Moreover, MX showed a tendency to enhance the development of intrahepatic cholangiocellular tumors and thyroid follicular cell tumors in the MNNG-treated animals. The results of the present study thus indicate that MX exerts promoting effects when given during the postinitiation phase of two-stage glandular stomach carcinogenesis in rats.  (+info)

(3/468) DNA copy number changes in thyroid carcinoma.

The genetic changes leading to thyroid cancer are poorly characterized. We studied DNA copy number changes by comparative genomic hybridization (CGH) in 69 primary thyroid carcinomas. In papillary carcinoma, DNA copy number changes were rare (3 of 26, 12%). The changes were all gains, and they were associated with old age (P = 0.01) and the presence of cervical lymph node metastases at presentation (P = 0.08). DNA copy number changes were much more frequent in follicular carcinoma (16 of 20, 80%) than in papillary carcinoma (P < 0.0001), and follicular carcinomas had more often deletions (13/20 versus 0/26, P < 0.0001). Loss of chromosome 22 was common in follicular carcinoma (n = 7, 35%), it was more often seen in widely invasive than in minimally invasive follicular carcinoma (54% versus 0%, P = 0.04), and it was associated with old age at presentation (P = 0.01). In three of the four patients with follicular carcinoma who died of cancer, the tumor had loss of chromosome 22. DNA copy number changes were found in 5 (50%) of the 10 medullary carcinomas studied. Four of these five carcinomas had deletions, and in two of them there was deletion of chromosome 22. Eleven (85%) of the thirteen anaplastic carcinomas investigated had DNA copy number changes, of which five had deletions, and one had deletion of chromosome 22. The most common gains in anaplastic carcinoma were in chromosomes 7p (p22-pter, 31%), 8q (q22-qter, 23%), and 9q (q34-qter, 23%). We conclude that DNA copy number changes are frequent in follicular, medullary, and anaplastic thyroid carcinoma but rare in papillary carcinoma when studied by CGH. Loss of chromosome 22 is particularly common in follicular carcinoma, and it is associated with the widely invasive type.  (+info)

(4/468) Relationship among 201T1 uptake, nuclear DNA content and clinical behavior in metastatic thyroid carcinoma.

A prospective study of 201TI uptake was performed to compare 201TI uptake with nuclear deoxyribonucleic acid (DNA) content and clinical behavior of tumors in metastatic thyroid carcinoma and to assess the significance of 201TI uptake in evaluating clinical characteristics of thyroid carcinoma. METHODS: Fifty-six patients with metastases of differentiated thyroid carcinoma had 201TI scintigraphy. Grade of 201TI uptake was semiquantitatively assessed according to tumor-to-background ratio on 2-h late scan. Nuclear DNA content was analyzed within 3 wk of 201TI study by flow cytometry using biopsy material and was classified as diploidy or aneuploidy. Patients were followed up to examine incidence of tumor growth and/or anaplastic transformation. RESULTS: DNA content was diploidy in 48 patients and aneuploidy in 8 patients. 201TI uptake in the DNA-aneuploid group (2.61 +/- 0.29) was significantly higher than that in the DNA-diploid group (1.82 +/- 0.35, P < 0.01 for both groups). Tumor growth was observed in all patients with DNA aneuploidy but in only 5 of 48 patients with DNA diploidy (P < 0.01). Anaplastic transformation was observed in 3 patients in the DNA-aneuploid group but in none of the patients in the DNA-diploid group. CONCLUSION: High 201TI uptake indicates greater incidence of abnormal DNA content with aggressive clinical behavior of metastatic tumors. Thus, 201TI scintigraphy may be useful in characterizing metastatic thyroid carcinoma and in identifying those patients with poorer prognoses.  (+info)

(5/468) Case-control study of thyroid cancer in Northern Italy: attributable risk.

BACKGROUND: The percentage of thyroid cancer cases attributable to specific risk factors can be calculated to focus preventive strategies. The per cent population attributable risks (PAR) for thyroid cancer were estimated in relation to history of benign thyroid diseases, history of radiotherapy, residence in endemic goitre areas and selected indicators of a poor diet, using data from a case-control study conducted between 1986 and 1992 in Northern Italy. METHODS: Cases were 399 histologically confirmed incident thyroid cancers and controls were 617 patients, admitted to hospital for a wide range of acute, non-neoplastic, non-hormone-related diseases. The PAR were computed on the basis of multivariate odds ratios (OR) and on the distribution of risk exposure among cases, assuming they are representative of the general population of cases. RESULTS: A history of benign thyroid disease accounted for 18.9% of cases, radiotherapy for 1.2%, residence for > or =20 years in endemic goitre areas for 2.4% of cases, and their combination for 21.7% of thyroid cancer cases; selected indicators of a poor diet accounted for 40.9% of thyroid cancer cases in this population. The combination of all factors considered explained over 57% of thyroid cancer cases in both sexes. The estimates for thyroid-related conditions were higher in women than men, whereas the opposite was true for dietary indicators. The overall PAR were somewhat higher in people aged > or =45 years (63.8%) than in younger subjects, and for follicular (69.1%) rather than papillary (53.7%) cancers. CONCLUSIONS: Exposure to a few simply identified and potentially modifiable risk factors or indicators (benign thyroid disease, residence in endemic goitre area and a poor diet) explained about 60% of thyroid cancer cases in this Italian population, indicating the theoretical scope for prevention.  (+info)

(6/468) Reproductive and hormonal risk factors for thyroid cancer in Los Angeles County females.

We conducted an individually matched case-control study (292 pairs) of female thyroid cancer patients to examine the role of reproductive history and exogenous hormones in this disease. Radiation treatment to the head or neck [28 cases and 2 controls exposed; odds ratio (OR), 14.0; 95% confidence interval (CI), 3.5-121.3] and certain benign thyroid diseases (including adolescent thyroid enlargement, goiter, and nodules or tumors) were strongly associated with thyroid cancer. Irregular menstruation increased risk (OR, 1.8; 95% CI, 0.9-3.7). Age at menarche and pregnancy history were not related to disease. Women with natural menopause and hysterectomized women without oophorectomy had no increase in risk, but disease risk was elevated in women with bilateral oophorectomy (OR, 6.5; 95% CI, 1.1-38.1). In general, use of oral contraceptives and other exogenous estrogens was not associated with thyroid cancer. However, risk increased with number of pregnancies in women using lactation suppressants (P = 0.03) and decreased with duration of breastfeeding (P = 0.04). These data provide only limited support for the hypothesis that reproductive and hormonal exposures are responsible for the marked excess of thyroid cancer risk in adult females.  (+info)

(7/468) Non-suppressed thyrotropin and elevated thyroglobulin are independent predictors of recurrence in differentiated thyroid carcinoma.

OBJECTIVE: Although in most cases differentiated thyroid carcinoma (DTC) responds to surgery and radioiodine (RaI) therapy, some patients will have recurrence and eventually cancer-related death. However, although various prognostic factors of DTC have been identified (e.g. staging, suppressed thyrotropin), none of the previous studies have assessed simultaneously their role in multivariate analysis. DESIGN AND METHODS: In this retrospective population-based study, we reviewed the clinicopathological data of 254 DTC patients treated in eastern Finland during the years 1976-1995, for clinical characteristics, primary treatment, follow-up and cancer recurrence. Tumor stage was based on pathological tumor-node-metastasis (pTNM) classification, and histopathological specimens were re-evaluated. RESULTS: DTC recurrence occurred in 33 patients (13%). In univariate analyses, the predictors of recurrence were older age (>60 years, P<0.05), follicular tumor type (P<0.01), pTNM classification system (P<0.05) and post-ablative radioiodine uptake outside the neck (P<0.05). Non-suppressed serum thyrotropin (TSH) and elevated serum thyroglobulin (>3 microg/l) measured one year after operation were both related to tumor recurrence (P<0.05 and P<0.001 respectively). In multivariate analysis the independent predictors for recurrence were both elevated thyroglobulin (P<0.001) and non-suppressed TSH (P<0.05) independent of histology, pTNM stage and RaI uptake. Adjusted risk ratio for recurrence of DTC for unsuppressed thyrotropin was 2.3, for elevated thyroglobulin 14.0 and, if both conditions were present, the risk ratio increased to 45.1. CONCLUSION: Our results suggest that both non-suppressed serum TSH and elevated serum thyroglobulin are related to an increased risk of DTC recurrence independent of tumor type and pTNM stage.  (+info)

(8/468) Expression of cytokeratin 20 in thyroid carcinomas and peripheral blood detected by reverse transcription polymerase chain reaction.

We investigated a nested reverse transcriptase polymerase chain reaction (RT-PCR) system to detect CK20 mRNA in thyroid carcinomas, benign thyroid diseases and peripheral blood to improve diagnosis of thyroid carcinoma and to detect disseminated tumour cells. Frozen tissue samples of 46 thyroid carcinomas and 30 benign thyroid diseases (14 multinodular goiters, 14 follicular adenomas, two Hashimoto's thyroiditis) were obtained intraoperatively. Preoperative blood samples were drawn from 31 patients with thyroid cancer, nine patients with benign thyroid disorders and 20 healthy volunteers. Nine out of nine medullary, 9/12 follicular, 7/19 papillary and 2/6 anaplastic carcinomas expressed CK20 transcripts. CK20 mRNA was undetectable in 30 tissue sections of benign thyroid diseases. Circulating tumour cells were found in the blood of 3/8 patients with medullary carcinoma, 2/8 patients with follicular carcinoma, 2/11 patients with papillary carcinoma and 1/4 patients with an anaplastic carcinoma. Nine blood samples of patients with benign thyroid diseases and 20 healthy volunteers tested negative. For the first time CK20 mRNA could be detected in tissue sections of thyroid carcinomas and peripheral blood samples of patients with thyroid cancer. It was not detectable in benign thyroid diseases. Our results therefore strongly suggest that CK20 RT-PCR assays may improve the diagnosis of thyroid carcinoma and is able to detect circulating tumour cells in peripheral blood of thyroid carcinoma patients.  (+info)

*  Thyroid disease
Thyroglobulin (TG) levels can be elevated in well-differentiated papillary or follicular adenocarcinoma. It is often used to ... non-cancerous tumor Thyroid cancer Papillary Follicular Medullary Anaplastic Lymphomas and metastasis from elsewhere (rare) ...
*  International Classification of Diseases for Oncology
M8330/3 Follicular adenocarcinoma, NOS (C73.9) Follicular carcinoma, NOS M8331/3 Follicular adenocarcinoma, well differentiated ... follicular variant (C73.9) Papillary adenocarcinoma, follicular variant Papillary and follicular adenocarcinoma Papillary and ... C73.9) Follicular carcinoma, well differentiated M8332/3 Follicular adenocarcinoma, trabecular (C73.9) Follicular carcinoma, ... follicular/follicle center, NOS M9691/3 Follicular lymphoma, grade 2 Follicular lymphoma, small cleaved cell M9698/3 Follicular ...
*  Signet ring cell
Neoplastic thyroid gland follicular signet ring cell Signet ring adenocarcinoma cell Signet ring melanoma cell Signet ring ...
*  List of MeSH codes (C04)
... adenocarcinoma, clear cell MeSH C04.557.470.200.025.060 --- adenocarcinoma, follicular MeSH C04.557.470.200.025.060.225 --- ... follicular MeSH C04.557.470.200.025.095 --- adenocarcinoma, scirrhous MeSH C04.557.470.200.025.095.410 --- linitis plastica ... carcinoma, papillary, follicular MeSH C04.557.470.200.025.075 --- adenocarcinoma, mucinous MeSH C04.557.470.200.025.085 --- ... follicular MeSH C04.557.386.480.350.350 --- lymphoma, large-cell, follicular MeSH C04.557.386.480.350.525 --- lymphoma, mixed- ...
*  NK2 homeobox 1
In the thyroid, follicular and parafollicular cells are also positive for TTF-1. For lung cancers, adenocarcinomas are usually ... TTF1 is more than merely a clinical marker of lung adenocarcinoma. It plays an active role in sustaining lung cancer cells in ... However others have found that TTF-1 staining is often positive in pulmonary adenocarcinomas, large cell carcinomas, small-cell ... "Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1". Cancer Research. 67 (13): 6007-11 ...
*  Leukotriene B4 receptor 2
The highest levels of Ras mutations are found in adenocarcinoma of the pancreas (90%), colon (50%), and lung (30%) Bos, 1989). ... follicular thyroid adenoma, Renal cell carcinoma, urinary bladder Transitional cell carcinoma, esophagus squamous cell ... The proliferation of Caco-2 human epithelial colorectal adenocarcinoma cells in culture was stimulated by 12-HETE and inhibited ... carcinoma, colon adenocarcinoma, the Serous cystadenocarcinoma type of ovarian cancer, and uterine cervical carcinoma. Other ...
*  MUC1
... from adenocarcinoma, in which it is diffusely spread through the cytoplasm. MUC1 has been shown to interact with: CTNND1, ERBB2 ... Epithelioid sarcoma Follicular dendritic cell sarcoma, interdigitating dendritic cell / reticulum cell sarcoma Lung: type II ... Adenocarcinomas (breast, colorectal, pancreatic, other) Carcinoid tumor Chordoma Choriocarcinoma Desmoplastic small round cell ...
*  Microfold cell
B cells have been implicated in the developmental of M cells, since they are also localized in high numbers in the follicular- ... Similarly, a human lymphoma cell line is also known to undergo transition from adenocarcinoma cells to M cells. Though many ...
*  List of cutaneous conditions
Primary cutaneous follicular lymphoma (follicular center cell lymphoma, follicular center lymphoma) Primary cutaneous ... Aggressive digital papillary adenocarcinoma (digital papillary adenocarcinoma, papillary adenoma) Apocrine gland carcinoma ... follicular mucinosis, Pinkus' follicular mucinosis-benign primary form) Localized lichen myxedematosus Myxoid cyst (digital ... follicular atrophoderma and basal cell cacinomas) Beare-Stevenson cutis gyrata syndrome Bloom syndrome (Bloom-Torre-Machacek ...
*  Tower Cancer Research Foundation
A Phase 2 Trial of Immunotherapy With Mitumprotimut-T (Id-KLH) and GM-CSF Following Rituximab in Follicular B-cell Lymphoma - ... resistant adenocarcinoma of the lung (NSCLA) - Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol ... Bortezomib, bendamustine, and rituximab in patients (pts) with relapsed (rel) or refractory (ref) follicular lymphoma (FL): ... Phase II trial of vatalinib in patients with advanced or metastatic pancreatic adenocarcinoma who failed gemcitabine therapy - ...
*  Renal cell carcinoma
It is considered an adenocarcinoma. There are two subtypes: sporadic (that is, non-hereditary) and hereditary. Both such ... Multilocular cystic clear cell renal cell carcinoma Tubulocystic renal cell carcinoma Thyroid-like follicular renal cell ...
*  P110α
"FDA approves new treatment for adults with relapsed follicular lymphoma". US Food and Drug Administration. September 14, 2017. ... "Mutations of PIK3CA in gastric adenocarcinoma". BMC Cancer. 5: 29. doi:10.1186/1471-2407-5-29. PMC 1079799 . PMID 15784156. ... got FDA approval for the treatment of adult patients with relapsed follicular lymphoma (FL) who have received at least two ...
*  HK3
... is found to be overexpressed in malignant follicular thyroid nodules. In conjunction with cyclin A and galectin-3, HK3 ... "Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma". Histology and ... cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules". Clinical Endocrinology. 68 (2): 252-7. doi: ...
*  MicroRNA
MiRNAs influence B cell maturation, generation of pre-, marginal zone, follicular, B1, plasma and memory B cells. A study of ... but not in sporadic colonic adenocarcinoma that lack mucinous components. In-vitro studies suggested that miR-205 and miR-373 ...
*  Adenoma
Adenocarcinoma Table 6-5 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology ... especially when the cells found at biopsy are of the follicular type. Pituitary adenomas are seen in 10% of neurological ... at which point they are called adenocarcinomas. Most adenomas do not transform. But even while benign, they have the potential ...
*  Endometrium
Endometrioid adenocarcinoma from biopsy. H&E stain. Micrograph of the endometrium. Micrograph of decidualized endometrium due ... Proliferation is induced by estrogen (follicular phase of menstrual cycle), and later changes in this layer are engendered by ... Baerwald, A. R.; Pierson, R. A. (2004). "Endometrial development in association with ovarian follicular waves during the ...
*  CEACAM6
2004). "CEACAM6 gene silencing impairs anoikis resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells". ... 50/90-like molecule on follicular keratinocytes". Arch. Dermatol. Res. 289 (8): 457-65. doi:10.1007/s004030050221. PMID 9266023 ...
*  PAEP
... follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in ... in endometrial adenocarcinoma and effect of medroxyprogesterone acetate". British Journal of Obstetrics and Gynaecology. 95 (12 ...
*  Index of oncology articles
... follicular large cell lymphoma - follicular mixed cell lymphoma - follicular thyroid cancer - formaldehyde - FR901228 - ... clear cell adenocarcinoma - clear-cell sarcoma - clear cell sarcoma of the kidney - clinical breast exam - clinical resistance ... thyroid follicular cell - thyroid hormone - thyroid-stimulating hormone - thyroidectomy - thyrotropin alfa - tiazofurin - time ... adenocarcinoma - adenoid cystic cancer - adenoma - adenopathy - adenosine triphosphate - adenovirus - adjunct agent - ...
*  Ovarian cancer
Low-grade serous adenocarcinomas resemble Fallopian tube epithelium, whereas high-grade serous adenocarcinomas show anaplasia ... including ovarian follicular cyst, leiomyoma, endometriosis, ectopic pregnancy, hydrosalpinx, tuboovarian abscess, ovarian ... Mucinous tumors include mucinous adenocarcinoma and mucinous cystadenocarcinoma. Mucinous adenocarcinomas make up 5-10% of ... Clear-cell adenocarcinomas are histopathologically similar to other clear cell carcinomas, with clear cells and hobnail cells. ...
*  Thymidine kinase in clinical chemistry
"Deoxythymidine kinase in the staging of prostatic adenocarcinoma". The Prostate. 29 (1): 15-9. doi:10.1002/(SICI)1097-0045( ... "High baseline serum thymidine kinase 1 level predicts unfavorable outcome in patients with follicular lymphoma". Leukemia & ...
*  IGFBP3
IGFBP-3 has been identified in human lymph, nipple aspirate, milk, amniotic fluid, follicular fluid, seminal plasma, urine, ... significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma". ...
*  Medroxyprogesterone acetate
Inhibition of follicular development and the absence of a LH surge prevent ovulation. A secondary mechanism of action of all ... Thomas DB, Ray RM (November 1995). "Depot-medroxyprogesterone acetate (DMPA) and risk of invasive adenocarcinomas and ... High-dose progestogen-only contraceptives, such as injectable DMPA, inhibit follicular development and prevent ovulation as ... Decreased levels of FSH inhibit follicular development, preventing an increase in estradiol levels. Progestogen negative ...
*  List of OMIM disorder codes
EGFR Adenocarcinoma of lung, somatic; 211980; BRAF Adenocarcinoma of lung, somatic; 211980; ERBB2 Adenocarcinoma of lung, ... follicular; 188470; MINPP1 Thyroid carcinoma, follicular; 188470; NRAS Thyroid carcinoma, papillary; 188550; GOLGA5 Thyroid ... somatic; 211980; PRKN Adenocarcinoma, ovarian, somatic; 604370; PRKN Adenomas, multiple colorectal; 608456; MUTYH Adenomas, ... ACADS Adenocarcinoma of lung, response to tyrosine kinase inhibitor in; 211980; ...
Premenopausal women are at highest risk for papillary and follicular thyroid carcinoma, implicating a role for estrogens in thyroid cancer. The expression of estrogen receptors α and β (ER), the effects of estradiol (E2), selective estrogen receptor modulators (SERMs) 4-hydroxytamoxifen and raloxifene, and ER subtype selective agonists were examined in NPA87 and KAT5 papillary and WRO follicular thyroid carcinoma cell lines. All three thyroid cancer cell lines expressed full-length ERα and ERβ proteins with cytoplasmic localization that was unaffected by E2. ICI 182,780 (Fulvestrant, an ER antagonist), and inhibitors of non-genomic E2-activated MAPK and PI3K signaling blocked E2-induced cell proliferation. SERMs acted in a cell line-specific manner. No E2-induced estrogen response element (ERE)-driven reporter activity was observed in transiently transfected thyroid cancer cells. However, E2 increased transcription of established endogenous E2-target genes, i.e., cathepsin D in WRO and ...
Thalidomide has found new uses as a tumor anti-angiogenesis agent that is capable of diminishing the proliferation of angiogenesis-dependent solid malignancies. Distantly metastatic, unresectable medullary thyroid carcinomas, as well as de-differentiated papillary and follicular thyroid carcinomas, which no longer concentrate radioiodine, have no known effective systemic therapies. We have verified, in the context of a completed phase 2 clinical trial, that thalidomide has significant activity in thyroid carcinomas that are no longer radioiodine avid and are rapidly progressive. This activity has only limited durability of around 7 months and is associated with significant toxicities of sedation, constipation and neuropathy.. REVLIMID® (lenalidomide) is an analog of thalidomide with the chemical name, alpha-(3-aminophthalimido) glutarimide. REVLIMID® is noted to be more potent than thalidomide in inhibiting the production of TNF-alpha. It has more than doubled the inhibition of microvessel ...
PubMedID: 24185120 | Prognostic Value of p27 in Follicular Thyroid Carcinoma and its Relation to Radioactive Iodine Response: Does it Aid in the Modification of Risk Stratification? | Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry | 10/31/2013
The report provides comprehensive information on the therapeutics under development for Follicular Thyroid Cancer, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
Results: CD56 expression was significantly higher in papillary thyroid carcinoma (PTC) (conventional and follicular variants) compared to other categories of follicular thyroid lesions, and it was significantly higher in the follicular variant of papillary carcinoma compared to follicular adenomas (FA) and hyperplastic nodules (HN). A bivariate analysis showed that the malignancy in follicular thyroid lesions was significantly associated with higher CD56 expression and older patients age. Both parameters were used to build a logistic regression model and equation for prediction of malignancy in follicular thyroid lesions. On the application of the equation to the studied cases, it was found to conform to their diagnostic nature ...
Factor VIII-related antigen is a recognised marker of endothelial cells. A brief immunocytochemical study of its distribution in follicular carcinoma of the thyroid and its value in the recognition of vascular invasion by this tumour has been carried out. Ten cases of follicular carcinoma of the thyroid were studied. In each strong endothelial staining was found in the majority of vessels in the adjacent normal thyroid. Lymphatic endothelium was negative. In eight of the 10 cases the staining of vessels within the tumour was absent or very weak. Staining was also absent in the majority of vessels completely occluded by tumour, but was present in the endothelium of vessels only partly occluded by tumour. It is concluded that factor VIII-related antigen staining has only limited value in the recognition of vascular invasion in follicular carcinoma. The absence of vascular staining in the tumour leads us to suggest that inhibition of factor VIII production by the tumour could be a possible ...
Abstract Outcome was compared in 1,004 patients with differentiated thyroid carcinoma (DTC) who underwent thyroid remnant ablation with 131I (n = 151) or were either treated with t..
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
Subjects will be seen weekly for the first 2 weeks, then again at Week 4, Week 8, and Week 12 after randomization, and every 12 weeks thereafter. Upon disease progression, all subjects (both active and placebo) will be unblinded and given the option to discontinue blinded study treatment and enter follow up and survival, or begin open label vandetanib (ZD6474) 300 mg treatment. All subjects will be followed to collect survival data until ≥50% of subjects have died. Subjects who are taking vandetanib (ZD6474) at the time of study closure and wish to remain on therapy will be allowed to continue for as long as the Investigator feels that they are obtaining clinical benefit, or until they are given another anti-cancer therapy. The safety data from all subjects will be assessed on an ongoing basis, including discontinuation and follow up ...
Hi, Im hoping to get some clarity on the findings of my biopsy report. I dont have it in front of me, but the report listed a few different type of cells. Follicular Carcinoma is the one my Endocron...
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Be Aware: A Suspicious Afirma GEC Can Cause You to Have a Needless Total Thyroidcetomy. "The NIFT-P Effect" Comment: The best use of GEC is when the result is benign, not when it is suspicious.This is just another reason to not.... More info ...
on the follicular tumour, from a highly experienced rat breeder on the NFRS forum. There are apparently different types and some contain hair follicules. They can get quite big, which I can imagine as Charlottes was growing fairly quickly and theres no particular reason why some rats get them. The good news is that its…
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Follicular thyroid carcinoma (FTC) is the second most common type of thyroid cancer after papillary carcinoma. It usually grows slowly and is clinically indolent; but rarely, its aggressive forms with distant metastases can occur. We report here an uncommon case of bilateral orbital metastasis of FTC. A 70-year-old woman presented with bilateral exophtalmus and past medical history of thyroid nodule surgery 15 years ago. Radiologic evaluation showed massive bilateral orbital mass with extension to calvarium. Tumor decompressed and removed with the suction and curettage and the patient was treated with chemoradiotherapy after operation. Pathologic examination showed metastatic follicular thyroid carcinoma. Although orbital metastasis of follicular thyroid carcinoma is uncommon, FTC should be considered as a potential primary neoplasm in a patient with orbital mass
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was previously classified as an encapsulated follicular variant of papillary thyroid carcinoma, necessitating a new classification as it was recognized that encapsulated tumors without invasion have an indolent behavior, and may be over-treated if classified as a type of cancer. Definition of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A noninvasive neoplasm that arises from the thyroid follicular cells (cells that normally make thyroid hormone), showing a predominantly follicular growth pattern and with nuclear features of papillary thyroid carcinoma. There are several specific inclusion and exclusion criteria (see below). When these are met, this tumor has an extremely low malignant potential. Abbreviations: NIFTP: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features EFVPTC: Encapsulated follicular variant of ...
Six patients experienced voice change immediately after RFA. Voice change was recovered in 5 patients. One patient without recovery was treated with vocal cord medialization. All 6 patients with voice change had tumors in the level VI. There were no other significant complications, and most of the patients tolerated the RFA procedure well. Although some patients reported a burning sensation, pain, or both, the symptoms were relieved by reducing the RF power or stopping the ablation for several seconds.. In conclusion, RFA can be effective in treating loco-regional, recurrent, and well-differentiated thyroid carcinoma in patients at high surgical risk.. ...
Three cases, two follicular and one of papillary thyroid carcinoma are reported. All three patients presented with subcutaneous cystic scalp metastases; they had a long-standing history of thyroid cancer, although two had never sought medical attention. We discuss this unusual clinical manifestation in patients with untreated well differentiated thyroid carcinoma ...
Papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) are the two most common thyroid cancers. They account for 90% to 95% of all thyroid malignancies and are most often seen in patients over 40 years of age (1). The tumor usually presents as an asymptomatic solitary intrathyroid nodule. In patients with FTC, distant metastases at the time of diagnosis are reported in 11% to 20% of patients (2). FTC tends to metastasize hematogeneously to lung and bone, whereas PTC is commonly metastatic to regional lymph nodes and lung. Synchronous lung metastasis in both types of cancers has been reported in ∼20% of cases, with a mean age at presentation of ,50 years (3).. Despite being classified collectively as well-differentiated thyroid carcinoma, PTC and FTC have distinct clinicopathologic features, biological behavior, and clinical outcome (4, 5). FTC is generally considered to be a more aggressive tumor than PTC and is associated with a worse prognosis. Patients with FTC often present ...
Persistent RET activation is a frequent event in papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC). In these cancers, RET activates the ERK/MAPK, the PI3K/AKT/mTOR and the JAK/STAT3 pathways. Here, we tested the efficacy of a JAK1/2- inhibitor, AZD1480, in the in vitro and in vivo growth of thyroid cancer cell lines expressing oncogenic RET. Thyroid cancer cell lines harboring RET/PTC1 (TPC-1), RET M918T (MZ-CRC1) and RET C634W (TT) alterations, as well as TPC-1 xenografts, were treated with JAK inhibitor, AZD1480. This inhibitor led to growth inhibition and/or apoptosis of the thyroid cancer cell lines in vitro, as well as to tumor regression of TPC-1 xenografts, where it efficiently blocked STAT3 activation in tumor and stromal cells. This inhibition was associated with decreased proliferation, decreased blood vessel density, coupled with increased necrosis. However, AZD1480 repressed the growth of STAT3- deficient TPC-1 cells in vitro and in vivo, demonstrating that its effects
Second of a new series of Mini-Editorials in Thyroid News. While accounting for only 1% of solid malignancies, thyroid carcinoma is the most common malignancy of the endocrine system. The majority are patients with well-differentiated thyroid carcinoma of follicular cell origin who are cured with adequate surgical management and radioiodine therapy. However, some thyroid malignancies, such as medullary thyroid carcinoma (MTC) or poorly differentiated thyroid carcinoma, frequently metastasize, precluding patients from a curative resection.. The molecular bases of differentiated thyroid carcinoma, MTC, and anaplastic thyroid cancer are well characterized and the critical genetic pathways involved in the development of specific tumor histological types have been elucidated. Of primary importance has been the recognition of key oncogenic mutations such as BRAF, RET and RAS in papillary (PTC) and RET in medullary (MTC) carcinomas. These genes code for kinases that activate signalling through the ...
The vast majority of low grade follicular cell derived thyroid carcinomas follows an indolent clinical course and is associated with very low mortality. Risk stratification using multiple clinical and pathologic characteristics has become the standard of care to guide appropriate management and avoid overtreatment. Over the past few decades, the field of thyroid pathology has witnessed several major changes that significantly impacted upon patients care. These are: 1) The reclassification of non-invasive encapsulated follicular variant of papillary thyroid carcinoma as noninvasive follicular thyroid neoplasm with papillary-like nuclear features; 2) the diagnosis of Hurthle cell carcinoma based on the presence of capsular and vascular invasion; 3) a detailed definition of poorly differentiated thyroid carcinoma, taking into consideration mitosis and necrosis; and 4) the emphasis on a detailed pathologic analysis such as the extent of vascular invasion and extrathyroidal extension ...
Using polymerase chain reaction and sequence-specific oligonucleotide hybridization, the frequency of three ras oncogene mutations (N-ras, Ha-ras, and K-ras) in thyroid tumors (25 adenomas, 16 follicular carcinomas, and 22 papillary carcinomas) was investigated in both iodide-deficient and iodide-sufficient areas. The ras oncogene mutation rate was significantly higher in the iodide-deficient area, being 85 versus 17% in the adenomas, and 50 versus 10% in the follicular carcinomas. No mutations were found in papillary carcinomas. The most common mutation site was Ha-ras codon 61 with Gln → Arg substitution. Two ras mutations at codon 61 (Gln → Lys in N-ras and Gln → Arg in Ha-ras) were found in a microfollicular adenoma specimen from Eastern Hungary. We conclude that dietary iodine may modulate ras oncogene mutations, and that in the iodide-deficient area, ras oncogene activation may play a more important role in the initiation and/or maintenance of follicular tumors. Additional factors ...
Ninety-four cases of encapsulated follicular variant of papillary thyroid carcinoma: A name change to Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features would help p…
05 Feb 2016. The incidence of differentiated thyroid cancer, which includes papillary and follicular cancers, has increased nearly threefold in the United States over the past three decades, and breast cancer is the most commonly diagnosed malignancy in women.. Advances in detection and treatment have resulted in many women surviving their initial illness, Grogan said.. "We now have large numbers of women who have survived one of the cancers. We saw evidence in the clinic that women who survived one seemed vulnerable to later developing the other," Grogan said.. Grogan and fellow researchers analysed studies of breast and thyroid cancer over several decades through a review of PubMed and Scopus databases.. The researchers queried the databases to find studies in which women who had survived either breast or thyroid cancer developed the other type later.. They then calculated odds ratios based on the numbers of observed and expected secondary malignancies.. The results showed that women who had ...
This trial will compare the diagnostic use of thyrotropin alfa [Thyrogen] with liothyronine in patients with papillary or follicular thyroid cancer. The primary
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
Sulforaphane (SFN) an all natural compound produced from broccoli/broccoli sprouts continues to be proven used seeing that an RITA (NSC 652287) antitumor agent in various types of malignancies. cell routine arrest and apoptosis and inhibited thyroid tumor cell migration and invasion by suppressing epithelial-mesenchymal changeover (EMT) procedure and appearance of and appearance with the activation of Erk and p38 signaling cascades and marketing mitochondrial-mediated apoptosis via reactive air species (ROS)-reliant pathway. Development of xenograft tumors produced from thyroid tumor cell range FTC133 in nude mice was also considerably inhibited by SFN. Significantly we didnt find significant aftereffect of SFN in body liver RITA (NSC 652287) organ and weight function of mice. Collectively we for the very first time demonstrate that SFN is certainly a possibly effective antitumor agent for thyroid tumor. types of either at the original presentation or being a recurrence which is certainly ...
Note: The determination of AJCC stage group from T, N, and M for thyroid depends on histologic type, grade, and age. The Histologies, Grade, Stage table shows the selection of the AJCC Stage table based on histology and grade. For papillary and follicular carcinomas, age is also needed for the selection; if age at diagnosis is unknown, AJCC stage will be derived as unknown for these histologies ...
This blog is about is about non-profits in our area. Its purpose is to promote events and share what is happening in the non-profit world. Patients, family members, friends, and clients need to know where to access information. Everything needs to be transparent to the general public. We need to know all the sound bites and what they are about. It impacts the social fabric of our communities. How do we find the help people so desperately need. Education of what is happening and why it is happening. This impact is so important to everyone. ...
Title: Heterogeneity in the distribution of RET/PTC rearrangements within individual post-Chernobyl papillary thyroid carcinomas. Author: Unger, K., Zitzelsberger, H., Salvatore, G.*, Santoro, M.*, Bogdanova, T.*, Braselmann, H., Kastner, P.,Zurnadzhy, L.*, Tronko, N.*, Hutzler, P., Thomas, G.:. J.. Reference: Clin. Endocr. Metab. 89, 4272-4279 (2004). Keywords:. Abstract: The nuclear disaster that occurred in Chernobyl in 1986 offered the unique opportunity to study the molecular genetics of one human tumor type, papillary carcinoma of the thyroid gland, associated with a specific etiology. We have analyzed RET rearrangements in post-Chernobyl papillary thyroid carcinomas (n = 29), follicular thyroid adenomas (n = 2), and follicular thyroid carcinoma (n = 1) by interphase fluorescence in situ hybridization (FISH) analysis on paraffin-embedded tissue sections. Paraffin sections were microdissected before use to ensure that only tumor was present. Cell nuclei were scored for the presence of a ...
Whereas adenomas and goiters belong to highly prevalent lesions of the thyroid not only in iodine-deficient regions malignant thyroid tumors are rare. Both papillary and follicular carcinomas of the thyroid are supposed to originate from the thyroid epithelium. At least for the follicular carcinomas a possible continuum from thyroid adenomas to follicular carcinomas has been proposed [21]. This idea is at least supported by a particular subtype of follicular tumors i.e. those characterized by a PAX8-PPARγ fusion due to a chromosomal rearrangement between chromosomal bands 2q13 and 3p25. As witnessed by the results of several studies, this abnormality can be found in follicular adenomas as well as in carcinomas [22-24]. However, the question arises whether or not other genetic subtypes of thyroid adenomas may predispose to malignant transformation. Recently, we have been able to demonstrate that translocations of chromosomal band 19q13.4, a frequent genetic alteration in thyroid adenomas, ...
Falls Church, Virginia. Sep. 22, 2012-A spectrum of disparities exist in the surgical management of well-differentiated thyroid cancer, according to new data presented at the 82nd Annual Meeting of the American Thyroid Association (ATA) in Québec City, Québec, Canada.. Current ATA guidelines for well-differentiated thyroid cancer recommend therapeutic neck dissection for clinically involved or metastatic disease and prophylactic central neck dissection for advanced tumors. However, even with established guidelines in place, the surgical management of cervical nodes varies greatly.. A team of researchers led by Katherine Hayes, MD, of Emory University in Atlanta, Ga., reviewed data on 127,192 patients with papillary and follicular thyroid cancer who were treated surgically from 1998 to 2009 to identify disparities in the extent of lymph node dissection during thyroidectomy. Variables examined included patient age, race, gender, insurance status and education level, hospital classification, ...
Objective: To assess predictors of well-differentiated thyroid cancer (WDTC) persistence/recurrence. Design: This was a retrospective chart review of thyroid carcinoma patients seen 1979-2007 in a Boston, Massachusetts-area multispecialty group. Of 1,025 patients, 431 met eligibility criteria. Cox proportional hazards models were used to assess predictors (gender, age, ethnicity, tumor size, surgical histology) of WDTC persistence/recurrence (elevated thyroglobulin levels with negative thyroglobulin-antibodies; or positive imaging). Local extension of disease and lymph node involvement could not be assessed. Results: Mean age at initial surgery (n = 431, 74% women, 79% Caucasian) was 45.8 \(\pm\) 13.5(SD) years. Mean tumor (papillary, 91%; follicular, 5%; Hurthle cell, 2%; \(\ge\)1 type, 2%) size was 2.5 \(\pm\) 1.6(SD) cm. Most tumors were unifocal (57%) and \(\ge\)1 cm (89%). Over 2,600 person-years of follow-up, persistence/recurrence occurred in 52 patients (12%) 4.3 years (median; range ...
The incidence of thyroid cancer, the most common endocrine malignancy, continues to increase steadily during the past few decades worldwide [1, 2]. The majority of thyroid cancer types are classified as: follicular epithelial cell-derived papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), anaplastic thyroid cancer (ATC), and para-follicular C-cell derived medullary thyroid cancer (MTC) [3]. The prognosis of patients with thyroid cancer is closely correlated with local invasion outside the thyroid capsule and the development of distant metastases [4]. Therefore, dissecting the molecular mechanisms underlying thyroid cancer invasion and metastasis is still imperative and may put new insight into the clinical treatment of thyroid cancer.. Human tumor-associated calcium signal transducer 2 (TACSTD2), also known as trophoblast cell-surface antigen 2 (Trop2), is a type I transmembrane glycoprotein originally identified in human placental trophoblastic tissue [5]. As a cell surface ...
TY - JOUR. T1 - Comprehensive genetic characterization of human thyroid cancer cell lines. T2 - A validated panel for preclinical studies. AU - Landa, Iñigo. AU - Pozdeyev, Nikita. AU - Korch, Christopher. AU - Marlow, Laura A.. AU - Smallridge, Robert Christian. AU - Copland, John A III. AU - Henderson, Ying C.. AU - Lai, Stephen Y.. AU - Clayman, Gary L.. AU - Onoda, Naoyoshi. AU - Tan, Aik Choon. AU - Garcia-Rendueles, Maria E.R.. AU - Knauf, Jeffrey A.. AU - Haugen, Bryan R.. AU - Fagin, James A.. AU - Schweppe, Rebecca E.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Purpose: Thyroid cancer cell lines are valuable models but have been neglected in pancancer genomic studies. Moreover, their misidentification has been a significant problem. We aim to provide a validated dataset for thyroid cancer researchers. Experimental Design: We performed next-generation sequencing (NGS) and analyzed the transcriptome of 60 authenticated thyroid cell lines and compared our findings with the known genomic defects ...
Anaplastic thyroid carcinoma is fatal if unresectable. However, improved survival has been reported after gross total resection and multimodality therapy. In this report, we describe the contrast-enhanced high-resolution CT characteristics of anaplastic thyroid carcinoma in 57 patients. Anaplastic thyroid carcinoma presented as a large neck mass with necrosis in 82% of cases. The tumors demonstrated common extrathyroidal extension (91%). Sixty-two percent of tumors demonstrated calcification. Visceral space invasion involved the esophagus (62%), trachea (57%), and larynx (29%). Carotid artery encasement was present in 42%, and 43% involved the internal jugular vein. Sixty-three percent had lateral compartment lymphadenopathy; 58% of these nodes were necrotic, and 11% were cystic. No metastatic nodes had calcification. Central compartment lymphadenopathy was seen in 56% of cases, and lateral retropharyngeal lymphadenopathy was detected in 12%. Knowledge of these imaging features aids in guiding ...
V.V. KHAZIEV Institute of Endocrine Pathology named after V.J. Danilevsky NAMS of Ukraine, 10 Artema St., Kharkiv, the Ukraine 61002 KhazievV.V. - Candidate of Medical Science, Head of the Department of Endocrine Surgery and Gynecology, e-mail: [email protected]¹ The expression of cytokeratins СK7, СK20, СК34Е12 was studied in 24 follicular adenomas drugs, 16 follicular cancers drugs and 19 papillary thyroid cancers drugs. Expression […]. ...
The preoperative diagnosis of thyroid lesions is not the only challenge faced by pathologists. Very often, establishing the differential diagnosis between benignancy and malignancy of a thyroid nodule, based only on the histopathological exam, can be quite difficult.. One of the greatest research challenges involving well-differentiated thyroid carcinoma is to develop a method to enable the correct differential diagnosis between benign and malignant lesions, trying to avoid a diagnostic surgery. To really reach this objective a test would need to have an especially high sensitivity rate,[11] but it has not yet been achieved in the literature even when genomic classifiers are employed[80]. Thus, the search for a "marker" that enhances this diagnostic capability is ongoing[81].. Cytokeratin-19 (CK-19) expression in thyroid nodules is in general intense and diffuse in papillary carcinoma and heterogeneous labeling in carcinoma and in follicular adenoma, with nil or low expression in other benign ...
Blood Vessel Inhibitor Shows Promise Against Metastatic Thyroid CancerResearchers also find evidence tying a genetic mutation to clinical outcomeThyroid cancer that has spread to distant sites has a poor prognosis, but an experimental drug that inhibits tumor blood vessel formation can slow disease progression in some patients, a research team led by investigators from The University of Texas M. D. Anderson Cancer Center reports in the July 3rd edition of The New England Journal of Medicine.The investigational drug, motesanib diphosphate, is a VEGF inhibitor, a biologic agent that targets receptors on a protein known as vascular endothelial growth factor (VEGF). VEGF is instrumental in angiogenesis (formation of new blood vessels), a process that allows tumors to grow and spread. Study lead author Steve Sherman, M.D., chair and professor of M. D. Andersons Department of Endocrine Neoplasia and Hormonal Disorders, noted strong evidence that VEGF receptors play an important role in metastatic ...
Although conventional histology and FNA are considered as gold standards, the pathologists are confronted with difficulties in reaching an accurate differential diagnosis between benign and malignant thyroid nodules. To improve disease identification, immunohistochemical markers, such as cytokeratin-19 (CK19) and galectin-3, have been proposed and their efficiencies for thyroid cancer diagnosis have been evaluated. CK19 is the smallest member of cytokeratin family and belongs to the intermediate filaments. Several studies reported that CK19 expression is strong and diffuse in papillary carcinoma and absent or low in benign thyroid lesions (8,9,15-17). Galectin-3, a structurally unique member of galectin family with an N-terminal tail composed of nine collagen-like repeats and a peptide with sites for Ser phosphorylation (39), is anti-apoptotic, associated with the pathogenesis of well-differentiated thyroid carcinoma (7,10-14). However, these markers have shown some limitations because ...
A thyroid neoplasm is a type of growth on the thyroid gland. Although a thyroid neoplasm can be either benign or malignant, it...
Core needle biopsy findings of a follicular neoplasm with a macrofollicular growth pattern. The images in the left column and the right column show the core nee
Through this trial the investigators hope to learn if a drug, Actos (pioglitazone), is useful in treating a certain kind of metastatic thyroid cancer. A
After several rounds of diagnostic tests 20 years ago, I had one lobe of my thyroid removed because it contained a hot nodule that was increasing in size. It turned out to be a follicular adenoma. My f...
Journal of Thyroid Research is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies the molecular and cellular biology, immunology, biochemistry, physiology and pathology of thyroid diseases, with a specific focus on thyroid cancer.
Information about anaplastic thyroid cancer, a rare but deadly form of thyroid cancer that mainly affects men over the age of 65.
The Anaplastic Thyroid Cancer GUIDELINES Pocket Card is endorsed by the American Thyroid Association reflects the latest ATA recommendations. This practical quick-reference tool contains graded recommendations for diagnosis, including immunohistochemical markers, and treatment of local, regional and metastatic disease with management algorithms and tables of chemotherapy and adjuvant/radiosensitizing regimens. Also included are recommendations for palliative care and long-term monitoring. Spiral Bound 14 pages 80# Diamond Silk Cover with Satin Aqueous Coating 4.5″ x 7.25″
Most cases of thyroid cancer are diagnosed in people who are 30 to 50 years of age. Rates of reported thyroid cases have risen by around 50% over the last 30 years around the world. It is unclear whether this trend represents a true rise, or whether health professional are simply getting better at diagnosing cases of thyroid cancer that in the past would have been overlooked, but the debate continues to include environmental risk factors such as radiation and pesticide use ...
Principal Investigator:FUJIHIRA Takashi, Project Period (FY):1996 - 1997, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:内分泌・代謝学
Introduction. While most types of thyroid cancer are treatable, anaplastic thyroid cancer (ATC) is the most lethal human malignancy. Current treatment strategies are largely ineffective with only 10% of patients surviving longer than one year. As such, new treatments are desperately needed to improve patient survival in this aggressive cancer.. Objective. Identify highly effective drugs using high-throughput screening methods with a large panel of kinase inhibitors that can be used in the treatment of ATC.. Methods. High-throughput screening (HTS) of 13 genetically characterized ATC cell lines was carried out over a 6-dose range using 320 kinase inhibitors. Dose-response curves were generated and drugs with high potency were identified. Drugs with the highest activity were selected for further evaluation including investigating mechanism of action and cell death, and assays for migration and invasion.. Results. Based on HTS studies, Lestaurtinib was identified as a highly effective agent with ...
Description thyroid cancer In the beginning it is necessary to define the term cancer. The general public conceives cancer for cancer of any kind, which is not correct. The term cancer should be reserved only for epithelial malignant tumors - cancers.
Monoclonal antibodies to dipeptidyl aminopeptidase IV (DAP IV, EC 3.4.14.5) were raised and selectively applied to paraffin-embedded sections of thyroid carcinoma. Five monoclonal antibodies were found to stain paraffin sections of thyroid carcinomas. Using one of these antibodies (44-4), we studied retrospectively aberrant expression of DAP IV in thyroid carcinoma to determine whether immunohistochemical staining with DAP IV antibody is useful in pathological diagnosis.. In almost all cases of thyroid follicular and papillary carcinoma, tumour cells were positive (99.0 per cent) with DAP IV, whereas the cases of follicular adenoma showed a low incidence (27.1 per cent) of positive staining. Follicular adenoma with incomplete capsular invasion had a higher positive incidence (50 per cent) than follicular adenoma without incomplete capsular invasion (9.6 per cent).. In positive staining cases previously diagnosed as benign tumours, 11 benign cases reacting positively with DAP IV were rediagnosed ...
Department of Internal Medicine 4, Saitama Medical School, 38 Morohongo, Moroyama, Iruma-gun, Saitama 350-0495, Japan. Zinc at concentrations of 150, microM or higher induced necrosis as well as apoptosis in thyroid cancer cell lines. Necrosis was induced by zinc in a dose-dependent manner, whereas apoptosis did not increase at higher concentrations of zinc. The expression of the antiapoptotic protein phosphorylated Bad was markedly increased, whereas the expression of the proapoptotic proteins Bax and Bad decreased following Zn(2+) exposure. Zn(2+) induced rapid degradation of IkappaB, and an increase in the binding of nuclear transcription factor-kappaB (NF-kappaB). These observations indicate that antiapoptotic pathways were activated in thyroid cancer cells following exposure to Zn(2+). This may be a self-defence mechanism against apoptosis and may underlie the general resistance of thyroid cancer cells to apoptotic stimuli. Zinc may be a potential cytotoxic agent for the treatment of ...
Micro-RNAs (miRNAs) belong to a class of small non-coding messenger RNA species that have emerged as potent regulators of a variety of biological processes including oncogenesis. They serve as master regulators with a single miRNA capable of regulating as many as 100 different target genes. Thyroid carcinomas encompass a wide spectrum ranging from well-differentiated thyroid carcinomas to poorly differentiated and anaplastic carcinoma. Currently, a considerable degree of interobserver variability exists in the morphological diagnosis of certain types of thyroid carcinomas especially the follicular pattern neoplasm. The prediction of progression of these differentiated carcinoma to more aggressive forms like poorly differentiated and anaplastic types is of considerable interest to physicians and pathologists for determining prognosis and making therapeutic decisions. Several investigators have proposed a more cohesive approach to thyroid cancer diagnosis incorporating molecular and proteomics ...
Introduction: We report an unusual case of adenocarcinoma of lung metachronous with stage IVA papillary thyroid carcinoma. The two tumors are morphologically similar; and the later presence of lung mass could clinically masquerade as metastatic thyroid carcinoma. We discuss the challenges in clinical, imaging and pathologic diagnosis. Case Report: A 64-year-old non-smoking female had a thyroidectomy and neck lymph node dissection for a stage IVA tumor with pathologic findings of one 2 mm microcarcinoma of left thyroid and six positive cervical lymph nodes. The post-surgical I131 whole body scan was negative and thyroglobulin is suppressed and stable (<1 ng/ml). One year later, she developed a ground glass and part-solid mass in the superior segment of left lower lobe of lung. The mass slowly grew increasing in size from 2.4 cm to 3.3 cm over 3 years. Biopsy of the lung lesion reveals morphologic features of nuclear inclusions and papillae similar to the previously diagnosed thyroid carcinoma. However,
Haugen BR, Sawka AM, Alexander EK, Bible KC, Caturegli P, Doherty GM, Mandel SJ, Morris JC, Nassar A, Pacini F, Schlumberger M, Schuff K, Sherman SI, Somerset H, Sosa JA, Steward DL, Wartofsky L, Williams MD. American Thyroid Association Guidelines on the Management of Thyroid Nodules and Differentiated Thyroid Cancer Task Force Review and Recommendation on the Proposed Renaming of Encapsulated Follicular Variant Papillary Thyroid Carcinoma Without Invasion to Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features. Thyroid. 2017 Apr; 27(4):481-483. PMID: 28114862. ...
We are looking source of medullary thyroid carcinoma cell lines. Three such lines are available from the ATCC (American Type Culture Collection) and we are obtaining these. However, at least one of these, a rat cell line called 6-23, is proving problematic to grow. We would appreciate help from other laboratories that might be able to provide us with cell lines and/or tips on culture conditions. The lines would be used for studies on the regulation of neuropeptide gene expression. ------------------------------------------------------------------------------ Tony Harmar MRC Brain Metabolism Unit Royal Edinburgh Hospital Edinburgh EH10 5HF Scotland ajharmar at uk.ac.ed.castle ...
Background: Thyroid cancer incidence has been increasing worldwide. Some suggest greater ascertainment of indolent tumours is the only driver, but others suggest there has been a true increase. Increases in Australia appear to have been among the largest in the world, so we investigated incidence trends in the Australian state of Queensland to help understand reasons for the rise. Methods: Thyroid cancers diagnoses in Queensland 1982-2008 were ascertained from the Queensland Cancer Registry. We calculated age-standardized incidence rates (ASR) and used Poisson regression to estimate annual percentage change (APC) in thyroid cancer incidence by socio-demographic and tumour-related factors. Results: Thyroid cancer ASR in Queensland increased from 2·2 to 10·6/100 000 between 1982 and 2008 equating to an APC of 5·5% [95% confidence interval (CI) 4·7-6·4] in men and 6·1% (95% CI 5·5-6·6) in women. The rise was evident, and did not significantly differ, across socio-economic and ...
Nucleolar prevalence, size, and outline were investigated on cytological material from cold thyroid nodules obtained by fine needle aspiration. The percentage of nucleolated nuclei in follicular adenoma (32 cases) was less than in follicular carcinoma (26 cases). In adenoma most nuclei contained one nucleolus, and nuclei with two or more nucleoli were less common than in carcinoma where most cases showed the highest nucleolar diameter values. There was some overlap between adenomas and carcinomas, however, when the mean of the 10 largest values of the major nucleolar diameter was considered. In follicular carcinoma the percentage of marginated nucleoli--that is, those touching the nuclear membrane--was, in general, greater than 20%; in adenoma the values were equal to or lower than 16%. The overlap index showed that the percentages of marginated nucleoli and nucleolated nuclei are the two best discriminatory features between adenoma and carcinoma.. ...
Medical information, Thyroid adenoma. Definition of Thyroid adenoma, symptoms of Thyroid adenoma, treatment of Thyroid adenoma, and prevention of Thyroid adenoma. Exams and Tests Thyroid adenoma.
RAS: Point mutations within RAS genes involve codons 12, 13, and 61 of NRAS, HRAS and KRAS, with mutations of NRAS and HRAS at codon 61 and of KRAS at codon 12/13 being the most common. Mutant RAS proteins constitutively activate the MAPK and PI3K/AKT pathways. In contrast to the other markers, RAS mutations are not restricted to a particular histological subtype of thyroid tumor. RAS mutations are found in ~ 10-15% PTCs (higher in follicular variant of PTC) but are more prevalent in FTC, where they are associated with 40%-50% of the cancers. RAS mutations are also found in ~35% of poorly differentiated and ~50% of anaplastic thyroid cancers, where the presence of RAS mutations seems to correlate with more aggressive tumor behavior and poor prognosis. RAS mutations are also found in 20%-40% of follicular adenoma, but it remains unclear whether these tumors represent pre-invasive follicular carcinomas ...
Well-differentiated thyroid carcinoma (DTC) is the most common endocrine malignancy that has an excellent prognosis with a 5-year survival rate of about 98 percent. However, approximately 50% of the patients with DTC who present with distant metastases (advanced DTC) die from the disease within 5 years of initial diagnosis even after getting the appropriate therapy. Apart from recent advancements in chemotherapy agents, the potential role of metabolic interventions including the use of metformin, ketogenic diet and high dose vitamin C in the management of advanced cancers have been investigated as a less toxic co-adjuvant therapies. The role of vitamin C has been of interest again after a pre-clinical mice study showed that high dose vitamin C is selectively lethal to KRAS and BRAF mutant colorectal cancer cells by targeting the glutathione pathway. This raises the possibility of utilizing high doses of vitamin C in the treatment of aDTC where KRAS and BRAF mutations are common. Similarly, alteration of
Health, ...Anaplastic thyroid carcinoma (ATC) is an aggressive type of cancer wit...Led by Professor H. Phillip Koeffler Senior Principal Investigator a...Thyroid cancer is the most common cancer of the endocrine system. ATC ... The effect of LAMC2 on ATC cells ...,NUS,researchers,make,new,discovery,of,protein,as,a,promising,target,for,treatment,of,ATC,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
This program explains thyroid cancer. The program includes the following sections: what is the anatomy of the thyroid, what is thyroid cancer, what are the causes and risk factors of thyroid cancer, what are the symptoms of thyroid cancer, how is thyroid cancer diagnosed, what is the staging of thyroid cancer and what are the treatment options for thyroid cancer.
... thyroid carcinoma (DTC) to ablate remnant thyroid cells after surgery. and 4.62?GBq. Our results revealed a significant correlation between the blood soaked up dose and blood sample activity and between the blood soaked up dose and whole body counts 24 to 48?hours after the Mupirocin IC50 administration of radioiodine. Intro Many people suffer from thyroid cancer yearly and differentiated thyroid carcinoma (DTC) is the most common type.1 Radioiodine therapy is known as an effective treatment of DTC to ablate remnant thyroid cells after surgery and to treat iodine-avid metastases.2 The different aspects of radioiodine therapy including methods, benefits, and risks can be found in the Western Association of Nuclear Medicine (EANM) recommendations and textbooks.2 Body organ absorbed estimation and dosages of rays risk is a significant problem in nuclear medication. As external rays dosimetry,3 inner rays dosimetry ...
New insight into how anaplastic thyroid cancer (ATC) grows and spreads may provide important direction in the development of treatment. These findings were published in the Journal of Clinical Endocrinology and Metabolism. The thyroid is a gland in the throat that produces hormones mostly related to metabolic processes in the body. There are different types of […]. ...
The commonest way that thyroid cancers are found is when someone notices a lump or nodule in the neck where the thyroid gland sits. This is usually painless and many patients feel otherwise well.. It is very important to know however, that having a lump in the thyroid is quite common and most lumps are NOT thyroid cancer. In fact only about 1 person in 20 presenting with a thyroid lump will have thyroid cancer as the cause of the lump. The other lumps will be benign and hence will not contain cancer.. Other possible ways for thyroid cancer to be diagnosed include:. ...
This form of cancer has an extremely low cure rate. The best treatments available allow only 10% of patients live 3 years after diagnosis. A larger percentage of patients diagnosed with it do not live beyond one year from the day cancer is diagnosed. It can arise within a different type of thyroid cancer. It can even form within a goiter. Anaplastic thyroid cancer can develop after many, many years following radiation exposure. Papillary cancer develops the same way. Cervical metastasis is when the cancer spreads to the lymph nodes in the neck. This is present in over 90% of patients diagnosed with anaplastic thyroid cancer. The appearance of lymph node metastasis in cervical areas cause much higher recurrence rate of anaplastic thyroid cancer and increases a patients mortality rate. The cancer becomes noticeable as growing neck mass. It can feel large and very hard. This type of tumor grows very quickly. It may grow so quickly that the patient may not even notice it at first. All of a sudden, ...
Thyroid cancer, thyroid cancer symptoms, symptoms of thyroid cancer, papillary thyroid cancer, thyroid cancer treatment, Call 1300 113 310
Global Markets Directs, Anaplastic Thyroid Cancer - Pipeline Review, H2 2016, provides an overview of the Anaplastic Thyroid Cancer pipeline landscape.. The report provides comprehensive information on the therapeutics under development for Anaplastic Thyroid Cancer, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for Anaplastic Thyroid Cancer and features dormant and discontinued projects.. Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Directs proprietary databases, ...
Quick background: I am a 26 y/o male, and I have aggressively pursued treatment of my thyroid and thyroid cancer. Here is my story and then my major question. Nov. of 2011 I went for a check-up because I was having problems focusing, getting out of bed, having energy and motivation through the day and gaining weight. Was diagnosed with Hoshimotothyroiditus. Doc asked if my thyroid was tender at all, I never noticed it before but now that he mentioned it yes it was. Ultrasound came back indicating multiple smaller nodules on the left and right lob and a larger nodule on the isthmus. Doc referred me to ENT and ENT sent me for a biopsy Jan. 13 2012, they only biopsied the nodule on the isthmus which measured 1.17x.59x1.02 CM. Biopsy indicated ( moderate groups of follicular cells, with areas of nuclear atypia, differential diagnosis, was follicular neoplasm and a follicular variant of papillary carcinoma. ENT says hes still not convinced its cancer, but wants to remove the nodule. I asked why not ...
Malignant tumors of the thyroid gland vary considerably in aggressiveness, ranging from a well-differentiated, clinically indolent, to an undifferentiated, often lethal phenotype. Undifferentiated (anaplastic) thyroid tumors are supposed to be derived, through a process of progression, from previously differentiated neoplasms. A common genetic alteration in thyroid tumors is the rearrangement of the tyrosine kinase-encoding RET proto-oncogene, leading to the generation of chimeric RET/PTC oncogenes. To define the characteristics of the thyroid tumor subset with RET rearrangements, we have investigated its activation by a combined immunohistochemistry and reverse transcription-PCR approach in a series of 316 well-characterized thyroid tumors representative of the main diagnostic groups. RET activation was detected in 81 of 201 (40.3%) papillary carcinomas. It correlated with tumors exhibiting the "classic" morphological features of papillary cancer or with the microcarcinoma subtype (P = 0.017). ...
Survival rates of thyroid cancer are based on outcomes of people whove had the disease. Find the survival rates for thyroid cancer here.
Chemotherapy is rarely used for thyroid cancer nowadays, but its sometimes used to treat anaplastic thyroid carcinomas that have spread to other parts of the body.. It involves taking powerful medicines that kill cancerous cells. It doesnt cure thyroid cancer, but may help control the symptoms.. More recently, newer medicines known as targeted therapies have been used more widely to treat several types of thyroid cancer. These specifically target cancer cells, rather than harming healthy cells at the same time as chemotherapy does.. Targeted therapies still arent offered routinely on the NHS, but may be available through the Cancer Drugs Fund in special circumstances. Alternatively, your care team may suggest taking part in a clinical trial studying targeted therapies for thyroid cancer.. ...
On the right is the clear separation of the target from the artery.. 2 Arrows show 5-10 mm separation.. Workshops on Thyroid tumor ablation for ethanol and RFA are planned for the USA and now are available in Italy and Korea with world expert teachers.. A preview Masters class tumor ablation 3-5 day course is available today at Santa Monica Thyroid Center.. Call Matt for details about all available workshops today ...
Question - What does oncocytic and hurthle cell features mean?. Ask a Doctor about diagnosis, treatment and medication for Hurthle cell cancer, Ask an Oncologist
Cancer researchers have identified a molecule linked to the survival of anaplastic thyroid carcinoma (ATC), a lethal tumor with no current effective therapies.
The study of thyroid tumor genetics has great relevance to surgeons and facilitates understanding tumor pathogenesis, prediction of tumor behavior, and management decisions. The genes implicated can b
The thyroid is located in the front of the neck. There are an estimated 53,000 new cases of thyroid cancer each year in the US. There are four major types: papillary, follicular, and medullary and anaplastic carcinomas.
Facts about thyroid cancer, including the three types of cancer, whos at risk, treatment options, and what to expect from life with thyroid cancer.
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Follicular and Hurthle cell cancers are two different types of cancer, but they are often considered in the same category. They can occur at any age, but are more likely in older people.
Upon diagnosis of thyroid cancer, a treatment plan should commence immediately to regain control of cellular growth and prevent cancer from spreading.
A recent report from the University of Wisconsin suggests that how thyroid cancer affects patients may vary with age, and treatment should be based on this knowledge, according to EmpowHer. The researchers discussed several theories as to how this type of cancer affects people of different ages.
Thyroid cancer management is evolving rapidly to a more minimalistic, individualized approach for low-risk patients, and more targeted and evidence-based therapeutic approaches for advanced-stage disease.
I cant believe it is almost 7 years since my diagnosis and surgery. Because of the relatively easy treatment for thyroid cancer it is sometimes easy to forget I had it at all. Im still checked every 3-6 months. I dont think about it much, until my doctor tells me I need to have additional…
Learn more about Medications for Thyroid Cancer at Largo Medical Center Main Page Risk Factors Reducing...
Learn more about Medications for Thyroid Cancer at Largo Medical Center Main Page Risk Factors Reducing...
Learn more about Medications for Thyroid Cancer at Coliseum Health System Main Page Risk Factors Reducing...
Learn more about Treatments for Thyroid Cancer at Grand Strand Medical Center Main Page Risk Factors ...
Treatments for Thyroid cancer, medullary including drugs, prescription medications, alternative treatments, surgery, and lifestyle changes.
Learn more about Thyroid Cancer at TriStar Centennial Parthenon Pavilion DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Staging is a careful attempt to learn whether the cancer has spread and, if so, to what parts of the body. Staging is based on the results of diagnosis.
Endocrine malignancies are very uncommon, but if they occur they are very difficult to detect and treat. These include Thyroid cancer which increase in incidence is likely due to improved diagnosis and to the increased use of therapeutic irradiation. Certain thyroid cancers remain undiagnosed during a persons life as the tumor cannot be treated.. Sub Tracks: ...
Hormonal Disorders: Children contains 3 articles on - GreenMedInfo contains 4 articles on Radioiodine 131 indicating it may contribute to Radiation-Induced Illness: Radioiodine (Iodine-131), Thyroid Cancer, and Radiation Induced Illness
Clinical evidence indicates that high periostin expression correlates with aggressive phenotype in thyroid carcinoma. However, the biological roles of periostin in thyroid carcinoma development and progression are still unclear. In this study, we explored the effects of periostin silencing on thyroid carcinoma cell growth, invasion, and tumorigenesis. We also studied the impact of periostin on the activation of phosphoinositide 3-kinase (PI3-K)/Akt signaling, which is involved in the pathogenesis of thyroid carcinoma. It was found that downregulation of periostin significantly inhibited the proliferation, colony formation, and invasion in both FTC-133 and BCPAP thyroid carcinoma cells. In vivo tumorigenic studies confirmed that periostin depletion retarded the growth of subcutaneous FTC-133 xenograft tumors, which was coupled with a significant decline in the percentage of Ki-67-positive proliferating cells. Western blot analysis demonstrated that periostin downregulation caused a marked inhibition of
A team of researchers led by Lindsey Kelly, MD, at the University of Pittsburgh Medical Center, analyzed 501 samples of papillary thyroid carcinoma using a panel of next-generation sequencing tools. They found that 73% were positive for known mutations and 27% were negative for known mutations. The majority of the latter were determined to be follicular variant of papillary thyroid carcinoma. Further analyses of follicular variant of papillary thyroid carcinoma tumors revealed TPM3/NTRK1 fusion with a novel breakpoint, as well as several promising SNVs and SVs. These findings may allow better characterization of the biology and clinical behavior of follicular variant of papillary thyroid carcinoma ...
Following up this article.. Malignant and possible malignant thyroid tumor of Fukushima children increased from 58 to 75 cases [URL]. Malignant and possible malignant thyroid tumor cases increased from 75 to 90 at the end of this March. Fukushima prefectural government announced on 5/19/2014.. Among 90 cases, 50 cases were confirmed as thyroid cancer.. The youngest child was 6 years old, the oldest child was 18 years old when 311 took place.. However the committee of experts stated it is hard to assume there is a connection with Fukushima nuclear accident.. http://www.pref.fukushima.lg.jp/uploaded/attachment/65174.pdf. http://ceron.jp/url/news.goo.ne.jp/article/jiji/nation/jiji-140519X151.html. ...
Mutation of the BRAF gene is common in thyroid cancer. Follicular variant of papillary thyroid carcinoma is a variant of papillary thyroid carcinoma that has created continuous diagnostic controversies among pathologists. The aims of this study are to (1) investigate whether follicular variant of papillary thyroid carcinoma has a different pattern of BRAF mutation than conventional papillary thyroid carcinoma in a large cohort of patients with typical features of follicular variant of papillary thyroid carcinoma and (2) to study the relationship of clinicopathological features of papillary thyroid carcinomas with BRAF mutation. Tissue blocks from 76 patients with diagnostic features of papillary thyroid carcinomas (40 with conventional type and 36 with follicular variant) were included in the study. From these, DNA was extracted and BRAF V600E mutations were detected by polymerase chain reaction followed by restriction enzyme digestion and sequencing of exon 15. Analysis of the data indicated ...
Although thyroid carcinoma is a relatively common form of malignancy, metastatic spread to the skull is rare. Here, we report a case of papillary thyroid carcinoma with frontal and parietal metastasis. A 61-year-old Chinese woman presented with a one year history of a growing mass on the center of the frontal and parietal bone, initially thought to be meningioma. Biopsy of the skull base mass after intracalvarium excision, indicated a tumor of thyroid origin. One month later the patient underwent a total thyroidectomy. Pathological examination confirmed a diagnosis of papillary thyroid carcinoma with frontal and parietal bone metastasis. Based on this experience, the key to successful management of the skull metastasis of thyroid carcinoma is prompt diagnosis and appropriate treatment. Skull metastasis should be considered at the outset of the clinical course of papillary thyroid cancer. To facilitate this, patients should be meticulously investigated by a multidisciplinary team to improve quality of
Thyroid carcinoma is a common endocrine malignancy worldwide, accounting for approximately 1% of all diagnosed cancers and about 91.5% of the malignancies of head and neck. However, differentiating malignant thyroid nodules from benign ones remains a diagnostic challenge. Thus, novel molecular markers that enable non-invasive diagnostics for malignant thyroid nodules are urgently needed. In the present study, a metabonomic investigation based on liquid chromatography-LTQ Orbitrap mass spectrometry was employed for serum metabolic profiling of 30 cases of papillary thyroid carcinomas (PTC), 80 cases of nodular goiters (benign thyroid nodules) and 30 cases of healthy controls. According to the results of multivariate statistical data analysis, the significantly changed metabolites among these three groups were defined. It was found that most of these metabolites decreased in the sera of both malignant and benign thyroid cases due to the increased metabolic rate, which is in accordance with ...
Gardners syndrome with duodenal adenomas, gastric adenomyoma and thyroid papillary--follicular adenocarcinoma.  Gardner's syndrome with duodenal adenomas, gastric adenomyoma and thyroid papillary--follicular adenocarcinoma.
... multicentric paillary-follicular adenocarcinoma of the thyroid, two tubulovillous adenomas of the duodenum in which ... Adenocarcinoma / pathology*. Adenoma / pathology*. Adult. Duodenal Neoplasms / pathology*. Female. Humans. Intestinal Polyps / ...
more infohttp://www.biomedsearch.com/nih/Gardners-syndrome-with-duodenal-adenomas/657934.html
Top Follicular Adenocarcinoma Hospitals in Bangalore  | Credihealth  Top Follicular Adenocarcinoma Hospitals in Bangalore | Credihealth
Get guidance from medical experts to select best follicular adenocarcinoma hospital in Bangalore ... View details of top follicular adenocarcinoma hospitals in Bangalore. ... Best hospitals for follicular-adenocarcinoma in Bangalore List of best hospitals for follicular-adenocarcinoma in Bangalore. ... Check OPD schedule of doctors and book appointment online top hospitals for follicular-adenocarcinoma in Bangalore.. Call 8010 ...
more infohttps://www.credihealth.com/hospitals/bangalore/follicular-adenocarcinoma
Top Follicular Adenocarcinoma Hospitals in Delhi NCR  | Credihealth  Top Follicular Adenocarcinoma Hospitals in Delhi NCR | Credihealth
Get guidance from medical experts to select best follicular adenocarcinoma hospital in Delhi NCR ... View details of top follicular adenocarcinoma hospitals in Delhi NCR. ... Best hospitals for follicular-adenocarcinoma in Delhi NCR List of best hospitals for follicular-adenocarcinoma in Delhi NCR. ... Need help in choosing the right follicular adenocarcinoma hospital? The medical expert will guide you for all hospital needs ...
more infohttps://www.credihealth.com/hospitals/delhi-ncr/follicular-adenocarcinoma
Compound Report Card  Compound Report Card
gastric adenocarcinoma. 3. ClinicalTrials. Adenocarcinoma, Follicular. D018263. EFO:0000501. follicular thyroid carcinoma. 1. ... Adenocarcinoma. D000230. EFO:0000228. adenocarcinoma. 2. ClinicalTrials. Colorectal Neoplasms. D015179. EFO:0000365. colorectal ... ductal adenocarcinoma. 3. ClinicalTrials. Carcinoma, Renal Cell. D002292. EFO:0000681. renal cell carcinoma. 1. ClinicalTrials ...
more infohttps://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1201585
Compound Report Card  Compound Report Card
Adenocarcinoma, Follicular. D018263. EFO:0000501. follicular thyroid carcinoma. 2. ClinicalTrials. Multiple Myeloma. D009101. ... colorectal adenocarcinoma. 4. ClinicalTrials. DailyMed. Endometrial Neoplasms. D016889. EFO:1001512. endometrial carcinoma. 2. ...
more infohttps://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1742982
Dr. Kris Guerrier, MD - Lakeland, FL - Radiation Oncology | Healthgrades.com  Dr. Kris Guerrier, MD - Lakeland, FL - Radiation Oncology | Healthgrades.com
Follicular Adenocarcinoma. - Follicular Thyroid Cancer. - Gall Bladder Cancer. - Gallbladder & Biliary Tract Cancer. ...
more infohttps://www.healthgrades.com/physician/dr-kris-guerrier-2nsfx
Dr. Joe Stephenson, MD - Greenville, SC - Hematology & Oncology | Healthgrades.com  Dr. Joe Stephenson, MD - Greenville, SC - Hematology & Oncology | Healthgrades.com
Follicular Adenocarcinoma. - Follicular Thyroid Cancer. - Gall Bladder Cancer. - Gallbladder & Biliary Tract Cancer. ...
more infohttps://www.healthgrades.com/physician/dr-joe-stephenson-xcxvr
Tanespimycin in Treating Patients With Inoperable Locoregionally Advanced or Metastatic Thyroid Cancer - Full Text View -...  Tanespimycin in Treating Patients With Inoperable Locoregionally Advanced or Metastatic Thyroid Cancer - Full Text View -...
Adenocarcinoma, Follicular. Carcinoma, Medullary. Carcinoma, Neuroendocrine. Neoplasms, Glandular and Epithelial. Neoplasms by ... Recurrent Thyroid Cancer Stage IV Follicular Thyroid Cancer Stage IV Papillary Thyroid Cancer Thyroid Gland Medullary Carcinoma ... Adenocarcinoma. Neuroendocrine Tumors. Neuroectodermal Tumors. Neoplasms, Germ Cell and Embryonal. Neoplasms, Ductal, Lobular, ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00118248
Dr. Edward Monk, MD - Brooklyn, NY - Dermatology | Healthgrades.com  Dr. Edward Monk, MD - Brooklyn, NY - Dermatology | Healthgrades.com
Follicular Thyroid Cancer. - Follicular Adenocarcinoma. - Papillary Thyroid Cancer. - Medullary Thyroid Cancer. - Hepatobiliary ...
more infohttps://www.healthgrades.com/physician/dr-edward-monk-ggb3x
REVLIMID® (Lenalidomide) for Therapy of Radioiodine-Unresponsive Papillary and Follicular Thyroid Carcinomas - Full Text View -...  REVLIMID® (Lenalidomide) for Therapy of Radioiodine-Unresponsive Papillary and Follicular Thyroid Carcinomas - Full Text View -...
Adenocarcinoma, Follicular. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. Endocrine System ... REVLIMID® (Lenalidomide) for Therapy of Radioiodine-Unresponsive Papillary and Follicular Thyroid Carcinomas. The safety and ... Alternatively, follicular or papillary thyroid carcinoma patients with large distant tumor burdens which have not sufficiently ... Adenocarcinoma. Lenalidomide. Thalidomide. Immunologic Factors. Physiological Effects of Drugs. Angiogenesis Inhibitors. ...
more infohttps://clinicaltrials.gov/show/NCT00287287
Ear burning sensation and Voice symptoms - Symptom Checker - check medical symptoms at RightDiagnosis  Ear burning sensation and Voice symptoms - Symptom Checker - check medical symptoms at RightDiagnosis
8. Adenocarcinoma of lung. 9. Adenocarcinoma, Bronchiolo-Alveolar. 10. Adenocarcinoma, Follicular. More causes » , Show All 496 ...
more infohttp://wrongdiagnosis.com/cosymptoms/ear-burning-sensation/voice-symptoms.htm
Dark and light patches on the skin and Lump - Symptom Checker - check medical symptoms at RightDiagnosis  Dark and light patches on the skin and Lump - Symptom Checker - check medical symptoms at RightDiagnosis
6. Adenocarcinoma. 7. Adenocarcinoma, Follicular. 8. Adenoid cystic carcinoma. 9. Adenoma. 10. Adult Fibrosarcoma. More causes ...
more infohttp://wrongdiagnosis.com/cosymptoms/dark-and-light-patches-on-the-skin/lump.htm
GPER | Cancer Genetics Web  GPER | Cancer Genetics Web
GPER1 and Follicular Adenocarcinoma. View Publications. 1. Note: list is not exhaustive. Number of papers are based on searches ... Role of GPER1, EGFR and CXCR1 in differentiating between malignant follicular thyroid carcinoma and benign follicular thyroid ... It is extremely difficult to discriminate between follicular thyroid carcinoma (FTC) and follicular thyroid adenoma (FTA) ... into thyroid follicular cells to facilitate thyroid hormone biosynthesis. Considering its fundamental role in thyroid function ...
more infohttp://www.cancerindex.org/geneweb/GPER.htm
Endocrine symptoms - RightDiagnosis.com  Endocrine symptoms - RightDiagnosis.com
Adenocarcinoma, Follicular ... hyperthyroidism*Adrenal adenoma, familial ... increased noradrenalin level, increased adrenalin ...
more infohttps://www.rightdiagnosis.com/sym/endocrine_symptoms.htm
Prevalence of Causes of Symptom: Endocrine symptoms  - RightDiagnosis.com  Prevalence of Causes of Symptom: Endocrine symptoms - RightDiagnosis.com
Adenocarcinoma, Follicular... hyperthyroidism *Adrenal adenoma, familial... increased noradrenalin level , increased adrenalin ...
more infohttps://www.rightdiagnosis.com/symptoms/endocrine_symptoms.htm
Thyroid disease - Wikipedia  Thyroid disease - Wikipedia
Thyroglobulin (TG) levels can be elevated in well-differentiated papillary or follicular adenocarcinoma. It is often used to ...
more infohttps://en.wikipedia.org/wiki/Thyroid_disease
anaplastic gastric carcinoma 2005:2010[pubdate] *count=100 - BioMedLib™ search engine  anaplastic gastric carcinoma 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-minor] Adenocarcinoma, Follicular / enzymology. Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Follicular / ... We have identified five papillary adenocarcinomas (8.2%), 28 tubular adenocarcinomas (46%), 17 signet-ring cell carcinomas ( ... MeSH-major] Adenocarcinoma / diagnosis. Neovascularization, Pathologic / diagnosis. Stomach Neoplasms / diagnosis. *[Email] ... Augustin G, Jelincic Z, Tentor D, Majerovic M, Matosevic P: Hepatoid adenocarcinoma of the stomach: case report and short notes ...
more infohttp://www.bmlsearch.com/?kwr=anaplastic+gastric+carcinoma+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Relevance of iodine intake as a reputed predisposing factor for thyroid cancer  Relevance of iodine intake as a reputed predisposing factor for thyroid cancer
The spontaneous malignancies reported in the iodine-deficient animals were follicular adenocarcinomas; 18% of females, but no ... After one year of this nutritional condition, follicular adenomas developed in 60% and follicular carcinomas became manifest in ... Because of the homogeneity of the growth potential of follicular cells (27), a fraction of these follicular cells in adults ... Thyroid follicular cell carcinogenesis: a review. Fundam Appl Toxicol 1989;12:629-97. [ Links ]. 18. Ohshima M, Ward JM. ...
more infohttp://www.scielo.br/scielo.php?pid=S0004-27302007000500007&script=sci_arttext
Endocrine Pathology  Endocrine Pathology
Follicular adenocarcinoma These are solitary, or multiple, encapsulated solid This well-differentiated, single, encapsulated ... Follicular cells 70 20−40 Lymph nodes 95 carcinoma Follicular Follicular cells 10 40−60 Bloodstream 60 Undifferentiated ... follicular C cells, which commonly synthesise In bone, PTH stimulates osteoclastic bone resorp- and secrete calcitonin but ... Papillary adenocarcinoma However, toxic changes occasionally occur in a This well-differentiated tumour is most commonly ...
more infohttps://www.slideshare.net/knickfan18/endocrine-pathology
  • Both chronic iodine deficiency and iodine excess have been associated with hypertrophy and hyperplasia of follicular cells, attributed to excessive secretion of TSH. (scielo.br)
  • For many common cancer classes, there are well recognized, clearly defined histopathological or molecular subtypes with differing etiologies or geographical prevalence that merit separate projects, for example transitional cell and squamous carcinomas of the urinary bladder or squamous and adenocarcinomas of the esophagus. (icgc.org)
  • Solid tumor size on high-resolution computed tomography and maximum standardized uptake on positron emission tomography for new clinical T descriptors with T1 lung adenocarcinoma. (ebscohost.com)