An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
The tunnel in the lower anterior ABDOMINAL WALL through which the SPERMATIC CORD, in the male; ROUND LIGAMENT, in the female; nerves; and vessels pass. Its internal end is at the deep inguinal ring and its external end is at the superficial inguinal ring.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Primary urethral carcinomas are rare and typically of squamous cells. Urethral carcinoma is the only urological malignancy that is more common in females than in males.
The external junctural region between the lower part of the abdomen and the thigh.
Inability to empty the URINARY BLADDER with voiding (URINATION).
Tumors or cancer of the VAGINA.
A histochemical technique for staining carbohydrates. It is based on PERIODIC ACID oxidation of a substance containing adjacent hydroxyl groups. The resulting aldehydes react with Schiff reagent to form a colored product.
Benign or borderline malignant neoplasm of the ovary and surrounding tissues. It is characterized by tumor(s) with cystic glands which are lined by cuboidal EPITHELIAL CELLS with clear cytoplasm, resembling ENDOMETRIUM cells. The glands are separated by fibroblastic STROMAL CELLS.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A malignant epithelial tumor with a glandular organization.
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)
Abnormally high level of calcium in the blood.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
Tumors or cancers of the KIDNEY.
Inorganic compounds which contain platinum as the central atom.
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.

Increased expression of the RIalpha subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer. (1/413)

The primary element in the cAMP signal transduction pathway is the cAMP-dependent protein kinase (PKA). Expression of the RIalpha subunit of type I PKA is elevated in a variety of human tumours and cancer cell lines. The purpose of this study was to assess the prognostic importance of RIalpha expression in patients with ovarian cancer. We have evaluated the expression of RIalpha in a panel of human ovarian tumours (n = 40) and five human ovarian cancer cell lines using quantitative reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis. The human ovarian cell lines OAW42 and OTN14 express high endogenous levels of RIalpha mRNA and protein (at significantly higher mRNA levels than high tissue expressors, P < 0.05). The ovarian cell line A2780 expresses low endogenous levels of RIalpha mRNA and protein (also at higher mRNA levels than low tissue expressors, P < 0.05). Quantitative RT-PCR revealed no significant difference in RIalpha mRNA expression between different ovarian histological subtypes in this study. No associations were found between RIalpha mRNA expression and differentiation state. RIalpha mRNA expression was significantly associated with tumour stage (P = 0.0036), and this remained significant in univariate analysis (P = 0.0002). A trend emerged between RIalpha mRNA expression levels and overall survival in univariate analysis (P = 0.051), however, by multivariate analysis, stage remained the major determinant of overall survival (P = 0.0001). This study indicates that in ovarian epithelial tumours high RIalpha mRNA expression is associated with advanced stage disease. RIalpha expression may be of predictive value in ovarian cancer and may be associated with dysfunctional signalling pathways in this cancer type.  (+info)

Loss of heterozygosity at 3p14.2 in clear cell renal cell carcinoma is an early event and is highly localized to the FHIT gene locus. (2/413)

The VHL tumor suppressor gene (TSG) at 3p25-26 is strongly implicated in the pathogenesis of clear cell renal cell carcinoma (cRCC). In addition, 3p14.2 and 3p21 are suspected of harboring additional TSGs in cRCC, with FHIT being a candidate TSG at 3p14.2. We examined 87 microdissected, histologically well-defined cRCCs classified according to tumor-node-metastasis (TNM) stage (stage 1, 23 cases; stage 2, 14 cases; stage 3, 24 cases; stage 4, 26 cases) and Fuhrman grade (grade 1, 24 cases; grade 2, 19 cases; grade 3, 19 cases; grade 4, 8 cases; sarcomatoid cRCC, 17 cases) for loss of heterozygosity (LOH) at 3p14.2 and 3p25-26 using a series of precisely mapped microsatellite probes. We found that LOH at 3p14.2 exceeded LOH at 3p25-26 in frequency (69% versus 48.3%; P < 0.03) and was highly localized to markers within the FHIT gene locus (D3S1300 and D3S4260), with the majority of chromosomal breakpoints also mapping to this region. In addition, 3p14.2 LOH (P < 0.03), but not 3p25-26 LOH (P = nonsignificant), was associated with lower tumor grades (grades 1-3). These findings suggest that 3p14.2 genomic deletions may be among the earliest events in cRCC pathogenesis, preceding genomic deletions at the VHL locus. FHIT, or an as yet undiscovered TSG mapping to the D3S4103-D3S4260 interval, could be the molecular target of the 3p14.2 deletions.  (+info)

Prognostic value of nuclear morphometry in patients with TNM stage T1 ovarian clear cell adenocarcinoma. (3/413)

In 40 patients with TNM stage T1 ovarian clear cell adenocarcinoma, we used nuclear morphometry to study the relations among morphometric variables, clinical prognostic factors and outcome. The presence of one or more giant nuclear cells was positively associated with death (OR = 10.6, P = 0.02) and tended to be associated with disease recurrence (OR = 5.1, P = 0.07). Nuclear irregularity (expressed in terms of the nuclear roundness factor) was positively associated with both death (OR = 8.6, P = 0.02) and disease recurrence (OR = 8.2, P = 0.02). A combination of giant nuclear cell presence or nuclear irregularity proved to be a useful prognostic indicator, with a sensitivity and specificity of 83% and 71% in the prediction of death, and 75% and 71% in the prediction of disease recurrence. Patients' age and substage were of no prognostic value. We conclude that the nuclear morphometric characteristics, especially the presence of giant nuclear cells and nuclear irregularity, may be useful in predicting outcome in patients with early stage ovarian clear cell adenocarcinoma.  (+info)

Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma. (4/413)

The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in patients with VHL disease and in the majority of patients with sporadic clear cell renal carcinoma (RCC). Overexpression of transforming growth factor (TGF) beta1 has been observed in patients with several cancers, including RCCs, with serum and urine levels correlating inversely with prognosis. We have demonstrated that the VHL tumor suppressor gene product represses TGF-beta1 mRNA and protein levels (approximately 3-4-fold) in 786-O RCC cells by decreasing the TGF-beta1 mRNA half-life. Exogenously added TGF-beta1 did not suppress the growth of 786-O cells in vitro, nor did the addition of neutralizing antibody (Ab) against TGF-beta have any effect. Indeed, 786-O cells were found to express no TGF-beta type II receptor protein, thus allowing them to escape from the negative growth control of TGF-beta1. In contrast to the in vitro data, neutralizing Ab to TGF-beta inhibited tumorigenesis and, in some cases, regressed established 786-O tumors in athymic mice. Immunohistochemistry for von Willebrand's factor revealed a 3-4-fold lower tumor microvessel count in the mice treated with TGF-beta Ab compared to controls, suggesting that the Ab was inhibiting angiogenesis. Our findings indicate that TGF-beta1 is a novel target for the VHL tumor suppressor and that antagonizing its paracrine action may provide novel avenues for treatment of RCCs as well as other tumors that secrete TGF-beta1.  (+info)

Clear cell carcinoma arising in a Cesarean section scar endometriosis: a case report. (5/413)

Endometriosis of a surgical scar is rare and occurs mainly when a hysterectomy or Cesarean section was performed. We describe a 54-year-old woman with a large suprapubic mass as a definite case of a endomerioid carcinoma developing within the scar endometriosis following Cesarean section. Scar endometriosis, as well as endometriosis at other sites, can turn malignant. Endometrioid carcinoma is the most common histological pattern of malignant tumor arising in endometriosis. But clear cell carcinoma is very unusual. A case of primary clear cell carcinoma in endometriosis of a Cesarean section scar is described. To the best of our knowledge, this is the first documented case of endomerioid carcinoma developing within the scar endometriosis in Korea.  (+info)

Overexpression of H-Ryk in mouse fibroblasts confers transforming ability in vitro and in vivo: correlation with up-regulation in epithelial ovarian cancer. (6/413)

Abnormalities in the function of receptor tyrosine kinases (RTKs) have been demonstrated to be important in the pathogenesis of cancer. H-Ryk, a new member of the RTK family, is an unusual RTK in that it is catalytically inactive because of amino acid substitutions of conserved residues in the catalytic domain. We show by immunohistochemistry that it is expressed in the epithelium, stroma, and blood vessels of normal tissues. Evaluation of a panel of 33 primary ovarian tumors (2 benign, 8 borderline, and 23 malignant) was performed. H-Ryk was overexpressed in borderline and malignant ovarian tumors. In serous and clear cell subtypes, there was increased expression in the epithelium, stroma, and blood vessels. Consistent with this observation, overexpression of H-Ryk in the mouse fibroblast cell line NIH3T3 induces anchorage-independent growth and tumorigenicity in nude mice. This implies that overexpression of the receptor can be transforming and may therefore be significant in the pathogenesis of ovarian cancer.  (+info)

Determination of telomerase activity for differential analysis of multifocal renal cell carcinomas. (7/413)

Secondary tumors are found in approximately 12 to 22% of all renal cell carcinoma, and their origin is currently unknown. To determine their potential for malignancy, we examined the telomerase activity of primary tumors and secondary lesions, and found that 86% of the lesions had an identical telomerase status as the related primary tumors, and thus probably share their malignancy potential.  (+info)

Hormone replacement therapy and risk of epithelial ovarian cancer. (8/413)

It has been suggested that oestrogen replacement therapy is associated with risk of epithelial ovarian cancer of the endometrioid type. Using data from an Australian population-based case-control study, the relation between unopposed oestrogen replacement therapy and epithelial ovarian cancer, both overall and according to histological type, was examined. A total of 793 eligible incident cases of epithelial ovarian cancer diagnosed from 1990 to 1993 among women living in Queensland, New South Wales and Victoria were identified. These were compared with 855 eligible female controls selected at random from the electoral roll, stratified by age and geographic region. Trained interviewers administered standard questionnaires to obtain detailed reproductive and contraceptive histories, as well as details about hormone replacement therapy and pelvic operations. No clear associations were observed between use of hormone replacement therapy overall and risk of ovarian cancer. Unopposed oestrogen replacement therapy was, however, associated with a significant increase in risk of endometrioid or clear cell epithelial ovarian tumours (odds ratio (OR) 2.56; 95% confidence interval (CI) 1.32-4.94). In addition, the risk associated with oestrogen replacement therapy was much larger in women with an intact genital tract (OR 3.00; 95% CI 1.54-5.85) than in those with a history of either hysterectomy or tubal ligation. Post-menopausal oestrogen replacement therapy may, therefore, be a risk factor associated with endometrioid and clear cell tumours in particular. Additionally, the risk may be increased predominantly in women with an intact genital tract. These associations could reflect a possible role of endometriosis in the development of endometrioid or clear cell ovarian tumours.  (+info)

The therapeutic effect of a combination of paclitaxel (PTX) and platinum (PLT) in ovarian clear cell adenocarcinoma (CC) patients with measurable disease has yet to be elucidated. In this study, we used retrospective review to evaluate the results of treatment with a combination of PTX and PLT in CC patients with measurable disease. A total of 28 patients with measurable residual CC (15 cases with primary disease, 13 cases with recurrent disease) treated with combination PTX-PLT chemotherapy was identified through medical records from ten institutions. Clinical response to chemotherapy was evaluated using Response Evaluation Criteria in Solid Tumors criteria. Of the 28 cases, 8 of 15 patients with primary disease (53.3%) and 3 of 13 patients with recurrent disease (23.1%) responded to PTX-PLT chemotherapy. The response rate for cases with late recurrent disease (,12 months) was 20% (1/5), whereas the rate was 25% (2/8) for cases with early recurrent (,12 months) or refractory disease. Our ...
TY - JOUR. T1 - Ovarian clear cell adenocarcinoma revealed in a young patient during hormone therapy: a case report. AU - Kawai, Satoshi. AU - Ichikawa, Ryoko. AU - Ueda, Takahiro. AU - Urano, Makoto. AU - Kuroda, Makoto. AU - Fujii, Takuma. PY - 2016. Y1 - 2016. U2 - 10.20407/fmj.2.4_77. DO - 10.20407/fmj.2.4_77. M3 - Article. VL - 2. SP - 77. EP - 79. JO - Fujita medical journal. JF - Fujita medical journal. SN - 2189-7247. IS - 4. ER - ...
Low expression of S100P is associated with poor prognosis in patients with clear cell adenocarcinoma of the ovaryLow expression of S100P is associated with poor prognosis in patients with clear cell adenocarcinoma of the ovary ...
TY - JOUR. T1 - Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells. T2 - Cytoplasmic sequestration of CDK2 by p27. AU - Itamochi, Hiroaki. AU - Yoshida, Tomokazu. AU - Walker, Cheryl Lyn. AU - Bartholomeusz, Chandra. AU - Aoki, Daisuke. AU - Ishihara, Hideki. AU - Suzuki, Nao. AU - Kigawa, Junzo. AU - Terakawa, Naoki. AU - Ueno, Naoto T.. PY - 2011/9. Y1 - 2011/9. N2 - Objective: Ovarian clear cell carcinoma (CCC) carries a poor prognosis because of its insensitivity to chemotherapy. We previously found an association between reduced proliferation of CCC and chemoresistance; here we investigated the mechanism of the reduced proliferation. Methods: We assessed cell cycle function by measuring the activity of cyclin-dependent kinases (CDKs) and the protein expression of cyclins, the CDK inhibitors, and p53 in 22 ovarian cancer cell lines and 60 human ovarian cancer specimens. We examined the cellular location of p27, p27 phosphorylated at threonine 157 (p27Thr157), and ...
Methylation of HIN-1 is associated with poor outcomes in patients with ovarian clear cell carcinoma (OCCC), which is regarded to be an aggressive, chemo-resistant histological subtype. This study aimed to evaluate whether 5-aza-2-deoxycytidine (5-aza-2-dC) can reverse methylation of the HIN-1 gene to restore chemo-sensitivity of OCCC and the possible mechanism. In vitro flow cytometric analysis and evaluation of caspase-3/7 activity of paclitaxel-sensitive and resistant OCCC cell lines were performed. Methylation status and expression changes of HIN-1 in the OCCC cell lines treated with 5-aza-2-dC were evaluated, and immunohistochemical staining of HIN-1 in OCCC tissues was performed. In vivo tumor growth with or without 5-aza-2-dC treatment was analyzed, and Western blotting of AKT-mTOR signaling-related molecules was performed. G2-M phase arrest was absent in paclitaxel-resistant OCCC cells after treatment with the cytotoxic drug. The caspase activities of the chemo-resistant OCCC cells were lower
Wolf-Hirschhorn syndrome candidate gene-1 (WHSC1), a histone methyltransferase, has been found to be upregulated and its expression to be correlated with expression of enhancer of zeste homolog 2 (EZH2) in several cancers. In this study, we evaluated the role of WHSC1 and its therapeutic significance in ovarian clear cell carcinoma (OCCC). First, we analyzed WHSC1 expression by quantitative PCR and immunohistochemistry using 23 clinical OCCC specimens. Second, the involvement of WHSC1 in OCCC cell proliferation was evaluated by MTT assays after siRNA-mediated WHSC1 knockdown. We also performed flow cytometry (FACS) to address the effect of WHSC1 on cell cycle. To examine the functional relationship between EZH2 and WHSC1, we knocked down EZH2 using siRNAs and checked the expression levels of WHSC1 and its histone mark H3K36m2 in OCCC cell lines. Finally, we checked WHSC1 expression after treatment with the selective inhibitor, GSK126. Both quantitative PCR and immunohistochemical analysis revealed that
Ovarian clear cell carcinoma is distinct from other epithelial ovarian cancers in terms of epidemiology, clinicopathological features, gene expression profile, and immune microenvironment. In the Western world, this is an uncommon disease and accounts for only 6% of epithelial ovarian cancer in the United States, but is far more prevalent in Singapore, the Republic of Korea, Taiwan, and Japan, where clear cell cancers constitute up to 25% of diagnosed ovarian cancer.1 2 Histologically, ovarian clear cell carcinoma is characterized by cells containing abundant clear glycogen-containing cytoplasm and may be associated with surrounding features of endometriosis. Immunohistochemistry typically demonstrates negativity for Wilms tumor 1 (WT1) and p53, but is often positive for hepatocyte nuclear factor 1-beta (HNF1-β).3. The treatment of women with advanced and recurrent ovarian clear cell carcinoma remains an area of significant unmet need. Clear cell ovarian cancers tend to occur in younger women ...
TY - JOUR. T1 - A New CA125‐like Antigen (CA602) Recognized by Two Monoclonal Antibodies against a Newly Established Ovarian Clear Cell Carcinoma Cell Line (RMG‐II). AU - Nozawa, Shiro. AU - Yajima, Masazumi. AU - Sasaki, Hirosuke. AU - Tsukazaki, Katsumi. AU - Aoki, Daisuke. AU - Sakayori, Motoko. AU - Udagawa, Yasuhiro. AU - Kobayashi, Toshifumi. AU - Sato, Ichiro. AU - Furusako, Shoji. AU - Mochizuki, Hiroshi. PY - 1991/7. Y1 - 1991/7. N2 - A cell line designated RMG‐II was established from the ascites of a patient with ovarian clear cell carcinoma. The chromosomal analysis revealed aneuploidy with a hypertetraploid modal numher and 8 marker chromosomes. Radioimmunoassay and immunocytochemical staining showed that RMG‐II cells produced some tumor markers such as CA125 and TPA. Two monoclonal antibodies, designated MA602‐1 and MA602‐6, were generated by immunization of mice with an extract prepared from the culture supernatant of RMG‐II cells. The epitopes recognized by these two ...
Purpose: Ovarian clear cell adenocarcinoma (OCCA) is an uncommon histotype that is generally refractory to platinum-based chemotherapy. We analyze here the most comprehensive gene expression and copy number data sets, to date, to identify potential therapeutic targets of OCCA.. Experimental Design: Gene expression and DNA copy number were carried out using primary human OCCA tumor samples, and findings were confirmed by immunohistochemistry on tissue microarrays. Circulating interleukin (IL) 6 levels were measured in serum from patients with OCCA or high-grade serous cancers and related to progression-free and overall survival. Two patients were treated with sunitinib, and their therapeutic responses were measured clinically and by positron emission tomography.. Results: We find specific overexpression of the IL6-STAT3-HIF (interleukin 6-signal transducer and activator of transcription 3-hypoxia induced factor) pathway in OCCA tumors compared with high-grade serous cancers. Expression of PTHLH ...
Clear cell adenocarcinoma of endobronchial origin is rare with only two case reports identified in a Pubmed search [1, 2]. Both of these reported cases occurred in adults, 45 years and 65 years of age. Our case is of a younger adult male of 27 years of age. The main differential diagnosis in this case is to rule out an adenocarcinoma with focal clear cell features, fetal adenocarcinoma, metastatic renal cell carcinoma, in additional to clear cell (sugar) tumor. The immunohistochemical stains being negative for CK5/6 and P63, as well as TTF1 and napsin A would make a diagnosis of either a squamous cell carcinoma or adenocarcinoma with clear cell features unlikely. The renal cell markers are negative. Sugar tumors are classically HMB-45 positive, and therefore our tumor is not in that category. The positivity of CK7 and PAS/PAS-D support an epithelial origin with glycogen positive cytoplasm. In our case, as well as the two case reports, this type of clear cell adenocarcinoma is known for an ...
Introduction: Ovarian Clear Cell Carcinoma (OCCC) is generally aggressive and chemoresistant, with five year survival rate of approximately 40%. Recent mutation analysis has indicated a high frequency of PIK3CA mutations, the gene encoding for the p110α subunit in PI3K, in OCCC. Aberrant signaling of the PI3K/AKT pathway might be linked to the aggressiveness of OCCC. In this study, we investigated the sensitivity of ovarian clear cell carcinoma cells with different PIK3CA mutations to inhibitors targeting the PI3K signaling pathway.. Experimental design: To elucidate the functional roles of PIK3CA mutations in OCCC, 12 OCCC cell lines carrying PIK3CA wildtype or different PIK3CA mutations were used. By performing WST-1 assay, the IC50 values for cisplatin of the cell lines were compared. Eight stable OCCC cell lines expressing a luciferase reporter fused with a FOXO3a promoter were constructed. FOXO3a is a transcription factor that is exported out of the nucleus by AKT. The difference in the ...
Urethral cancer is a rare malignancy with urothelial subtype being the most common followed by adenocarcinoma. In women, the usual presentation is urinary retention and hematuria.
Thus investigators should avoid using maternal recall alone to measure DES exposure. Among subjects for whom written maternal obstetric records were available, 88% of vaginal cases and 46% of cervical cases were DES positive. The authors conclude that few cases of vaginal clear cell adenocarcinoma should occur in young women as the cohort of women exposed in utero to DES continues to age, whereas cases of cervical origin may continue to occur.. Sources: Clear cell adenocarcinoma of the lower genital tract. Correlation of mothers recall of diethylstilbestrol history with obstetrical records, NCBI, Dr Herbst A, Nov 1990. See also: Are you a probable DES Daughter ...
The patient received a potassium supplement, intramuscular administration of calcitonin, and intravenous (IV) fluid hydration, and she was admitted to the hospital for further workup. After treatment with IV fluids, calcitonin, and zoledronic acid, her calcium level decreased to 11.5 mEq/L. With improvement of her nausea and vomiting, the patient was discharged. It was recommended that she follow-up with an oncologist as an outpatient.. Approximately 1 week later, the patient returned to the Emergency Department with similar symptoms and was found to have an elevated calcium level of 15 mEq/L. She was given IV fluids and pamidronate, which improved her symptoms. She was discharged, with further workup to be done on an outpatient basis. This patient presented a total of 4 times to the Emergency Department with similar symptoms of hypercalcemia, as shown in Figure 1.. A bone marrow biopsy was performed, and the specimen demonstrated trilineage hematopoiesis without signs of myeloma. Specifically, ...
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What is Germ Cell Ovarian Cancer? Get the facts about Germ Cell Ovarian Cancer symptoms, testing, treatment and care options from trusted sources.
Clear cell carcinoma of the uterine cervix: clinical characteristics and feasibility of fertility-preserving treatment Xiang Jiang, Ying Jin, Yan Li, Hui-Fang Huang, Ming Wu, Keng Shen, Ling-Ya Pan Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China Abstract: The objective of this retrospective study was to analyze the clinical characteristics and prognosis of clear cell adenocarcinoma (CCA) in the post-diethylstilbestrol (DES) era and to evaluate the feasibility of fertility-preserving treatment. The records of 32 patients with CCAs who were treated at Peking Union Medical College Hospital from August 1986 to June 2012 were retrospectively reviewed. Three of the patients had undergone fertility-preserving treatment. The incidence of CCA among cervical adenocarcinomas was 15.2%. The median age was 38 years: 11 patients (34.4%) were diagnosed before 30 years of age
Clear cell adenocarcinoma (CCC), a subtype of epithelial ovarian cancer, is less sensitive to chemotherapy and is thus classified as a refractory ovarian cancer [1]. It has been shown that a combination of carboplatin (CBDCA) and paclitaxel (PTX ), a standard therapy for ovarian cancer [2, 3], is effective against serous adenocarcinoma and endometrioid adenocarcinoma, with a response rate of approximately 75%, while CCC has lower response rates ranging from 18% to 50% [4]. The incidence of CCC has been increasing and is now 25% in Japan, while that in Europe is 5-6%. As yet, no treatment for this histological subtype of ovarian cancer has been established. Histopathology remains the gold standard for classifying epithelial ovarian cancer subgroups; however, there is emerging evidence indicating different genetic and molecular profiles. Consequently, there is no international consensus regarding the necessity of establishing treatment strategies based on histological subtypes. In fact, global ...
PRIMARY OBJECTIVES:. I. To assess the activity of the study regimen as measured by the proportion of patients who are alive and progression-free for at least 12 months after study entry in patients with newly diagnosed stage III or IV clear cell ovarian cancer in the following populations: patients in the United States (U.S.) and worldwide (outside of Japan) and patients in Japan.. II. To compare progression-free survival in newly diagnosed stage III or IV clear cell ovarian cancer patients in patients in the U.S. and worldwide (outside of Japan) versus patients in Japan.. SECONDARY OBJECTIVES:. I. To characterize the duration of overall survival and progression-free survival in each population.. II. To examine the frequency and severity of adverse events as assessed by Common Terminology Criteria for Adverse Events (CTCAE) version 4 in each population.. III. To estimate the rate of objective tumor response in patients with measurable disease.. TERTIARY OBJECTIVES:. I. To explore whether ...
TY - JOUR. T1 - Salivary Clear Cell Carcinoma Clinicopathologic Characteristics and Outcomes. T2 - A Population-Based Analysis. AU - Sharbel, Daniel D.. AU - Unsal, Aykut A. AU - Groves, Michael W. AU - Albergotti, William Greer. AU - Byrd, James Kenneth. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background: Salivary clear cell carcinoma is an uncommon, low-grade malignancy for which limited data describing predictive clinicopathologic factors and treatment outcomes exist because of rarity. Methods: The authors queried the Surveillance, Epidemiology, and End Results database from 1982 to 2014. Multivariate Cox and Kaplan-Meier analyses were performed to determine disease-specific survival (DSS) and predictive clinicopathologic factors. Results: One hundred ninety-eight patients with salivary clear cell carcinoma were included. Overall incidence was 0.011 per 100 000 individuals, with no significant annual percentage change across years (−0.93%, P =.632). Five-, 10-, and 20-year DSS rates were 81.3% ...
One of my relatives was diagnosed with |b|cancer of the left kidney|/b|. The kidney has been removed three days back. The frozen section analysis revealed renal clear cell carcinoma. The histopathological report is awaited. What is clear cell carcinoma? Is it the more aggressive type or relatively milder? Can you please clarify this clear cell terminology?
Clear cell ovarian tumors are part of the surface epithelial-stromal tumor group of ovarian cancers, accounting for 6% of these cancers. Clear cell tumors are also associated with the pancreas and salivary glands. Typically, they are cystic neoplasms with polypoid masses that protrude into the cyst. On microscopic pathological examination, they are composed of cells with clear cytoplasm (that contains glycogen) and hob nail cells (from which the glycogen has been secreted). The pattern may be glandular, papillary or solid. Benign and borderline variants of this neoplasm are rare, and most cases are malignant. These tumors may have a worse prognosis than serous tumors. Chan JK, Teoh D, Hu JM, Shin JY, Osann K, Kapp DS (June 2008). Do clear cell ovarian carcinomas have poorer prognosis compared to other epithelial cell types? A study of 1411 clear cell ovarian cancers. Gynecol. Oncol. 109 (3): 370-6. PMID 18395777. doi:10.1016/j.ygyno.2008.02.006. Clear Cell Carcinoma of Ovary at University of ...
TY - JOUR. T1 - Adnexal clear cell carcinoma with comedonecrosis. T2 - A case report. AU - Kim, Seo Hee. AU - Han, Sun Hee. AU - An, Jung Suk. AU - Lee, Ju-Han. AU - Lee, Eung Seok. AU - Park, Heum Rye. AU - Kim, Young Sik. PY - 2010/2/1. Y1 - 2010/2/1. N2 - Adnexal clear cell carcinoma with comedonecrosis (ACCCC) is a very rare malignancy of the skin with an aggressive clinical course and a predilection for the scalp. This is the first reported case of ACCCC in Korea. A 79-year-old male presented with left abdominal masses that proved to be two subcutaneous nodules. The tumors histologically consisted of epithelial nests that showed a distinctive zonal arrangement. The centrally located clear cell areas with comedonecroses were merged with the peripheral squamoid cells, often exhibiting retraction artifacts and an infiltrating border. Nuclear pleomorphism and frequent mitoses were prominent. The clear cells were immunopositive for carcinoembryonic antigen and epithelial membrane antigen. We ...
Kidney renal clear cell carcinoma (KIRC) is the most common renal cell carcinoma (RCC). However, patients with KIRC usually have poor prognosis due to limited biomarkers for early detection and prognosis prediction. In this study, we analysed key genes and pathways involved in KIRC from an array dataset including 26 tumour and 26 adjacent normal tissue samples. Weighted gene co-expression network analysis (WGCNA) was performed with the WGCNA package, and 20 modules were characterized as having the highest correlation with KIRC. The upregulated genes in the tumour samples are involved in the innate immune response, whereas the downregulated genes contribute to the cellular catabolism of glucose, amino acids and fatty acids. Furthermore, the key genes were evaluated through a protein-protein interaction (PPI) network combined with a co-expression network. The comparatively lower expression of AGXT, PTGER3 and SLC12A3 in tumours correlates with worse prognosis in KIRC patients, while higher ...
The types of treatments given for germ cell ovarian cancer are based on the unique needs of the woman with cancer. Being able to have children in the future is important for some women, so doctors will consider this when planning treatment.
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To confirm that COP1 is overexpressed in these tumors at the protein level, immunohistochemistry analysis using a specific antibody to COP1 was done on the same ovarian tissue microarray described above as well as the ovarian samples used for RT-PCR in Fig. 2A ⇓ . The tissue microarray showed 47% (11 of 27) of serous adenocarcinomas, 63% (12 of 19) of endometrioid adenocarcinomas, 36% (4 of 11) of clear cell adenocarcinomas, and 50% (5 of 10) of mucinous adenocarcinomas displayed a robust COP1 immunoreactivity within the nuclear and cytoplasmic compartments of the malignant cells; however, no signal was detected within the stroma (Fig. 2C) ⇓ . In addition, normal tissues were negative for any reactivity with the COP1 antibody (data not shown). Collectively, these data indicate that COP1 mRNA and protein are specifically overexpressed in the malignant cells. There was relatively good agreement with the in situ hybridization and immunohistochemistry data (data not shown); however, endometrioid ...
DISEASE CHARACTERISTICS: Histologically confirmed advanced ovarian epithelial malignancy of one of the following histologies: Serous adenocarcinoma Endometrioid adenocarcinoma Mucinous adenocarcinoma Undifferentiated carcinoma Clear cell adenocarcinoma Mixed epithelial carcinoma Fallopian tube and extraovarian peritoneal papillary serous tumors also allowed Documented responsiveness (using established clinical criteria) to a platinum-based chemotherapy regimen required Partial or complete clinical response to the most recent chemotherapy regimen required Bone marrow aspirate and biopsy morphologically negative for carcinoma and cellularity greater than 50% No CNS involvement. PATIENT CHARACTERISTICS: Age: 18 to 65 Performance status: GOG 0-2 Life expectancy: Not specified Hematopoietic: WBC greater than 3,000/mm3 Absolute neutrophil count at least 1,500/mm3 Platelet count greater than 100,000/mm3 Hepatic: Bilirubin less than 1.5 mg/dL* SGOT less than 60 IU/mL* * Unless abnormality due to ...
The findings were published online by the journal Nature Medicine.. Ovarian cancer is divided into four different histological subtypes. One of the subtypes is ovarian clear cell carcinoma, which affects approximately 5 to 10 percent of American ovarian cancer patients and about 20 percent of patients in Asia. While most patients with ovarian cancer initially respond well to standard-care platinum-based chemotherapy, the response rate among those with the clear cell subtype is typically low and there is currently no effective therapy for these patients. This underscores the need for a new approach to treating this deadly disease.. One of the significant challenges with the treatment of ovarian cancer is finding a suitable target that effectively halts the progression of the disease in a personalized manner based on ones genetic makeup, said Rugang Zhang, Ph.D., associate professor in Wistars Gene Expression and Regulation Program and corresponding author of the study. With this study, we ...
Atlas of Clear Cell Carcinoma of the Ovary auf frohberg.de - Clear cell carcinoma (CCC) of the ovary with its unique clinical and biological features has...
The clinicopathologic findings and prognosis of surgically treated patients with stage IB-IIB clear cell carcinomas without exposure to diethylstilbestrol in utero are similar to those of patients with squamous cell carcinomas and non-clear cell adenocarcinomas.
1. Akan H, Küçük M, Balat Ö, et al. The diagnostic value of cranial computed tomography in complicated eclampsia. Journal Belge de Radiologie (JBR-BTR) 1993; 76: 304-306. 2. Kökçü A, Üstün C, Balat Ö, et al. Basal Ganglia and white matter in pregnancy-induced hypertension. Neuroradiology 1993 ; 35: 284-5. 3. Sönmez S, Kafkaslı A, Balat Ö, et al. Cervical pregnancy: can age and parity be predisposing factors? Acta Obstet Gynecol Scand 1994; 73: 734-6. 4. Balat O, Kudelka AP, Edwards CL, et al. Malignant transformation in endometriosis of the urinary baldder : a case report of clear cell adenocarcinoma. Eur. J. Gynaec. Oncol 1995;1:13-16. 5. Kavanagh JJ, Edwards CL, Freedman RS, Finnegan MB, Balat O, et al. A trial of loboplatin (D-19466) in platinum-resistant ovarian cancer. Gynecologic Oncology 1995; 58:106-109. 6. Soysal O, Balat O, Kudelka AP, et al. Oncogene and tumor supressor gene therapy for cancer. Cancer Molecular Biology (CMB) 1995; 4:591-596. 7. Balat O, Verschraegen C. ...
Malignant Tumors of Female Internal Genitalia & Ovaries - UrologyWeb Clear cell adenocarcinoma of the vagina and cervix is rare. The increase and occurrence of this tumor has been linked with the maternal use of
Its a startling reality that DES Mothers, DES Daughters and DES Sons live with-that not many people know about or have heard about the pregnancy drug DES-diethylstilbestrol-or the harmful effects its had on both mothers who took the drug, and children who were exposed to the drug in utero.. DES was prescribed during the 1940s to the 1970s to expectant mothers who were at risk for miscarriage or pre-term delivery. The drug, however, was found to potentially cause clear cell adenocarcinoma (CCA), a rare form of vaginal and cervical cancer; reproductive tract structural changes such as a T-shaped uterus; complications in pregnancy such as ectopic (tubal) pregnancy and pre-term delivery; and infertility.. DES finally had its FDA approval revoked in 2000 (it had been recommended that doctors not prescibe it in 1971)-but not until potentially millions of mothers and children had been negatively affected by it. And those children are now between forty and seventy years of age or so-some of whom have ...
The first complex isolated was SWI/SNF in yeast[4], with the catalytic subunit being identified as SNF2. In humans, 3 homologues of SWI/SNF proteins have been identified; hbrm and BRG1, which are homologous of SNF2/SWI2 and hSNF5, which is a homologue of SNF5[5]. Hbrm and BRG1 promote transcriptional activation via the glucocorticoid and retonic acid receptors[6]. BRG1 has been found to activate or repress nuclear processes (transcription, elongation, DNA replication), using various mechanisms including being assembled with transcriptional promoters and histone-modifying enzyme complexes[7]. As SWI/SNF plays a key role in the cell cycle, it has been indicated to be a potent tumour suppressor. Mutations within subunits of these complexes have been linked to more than 20% of human cancers[8]. The cancers with the highest SWI/SNF mutation rates were ovarian clear cell carcinoma (75%), clear cell renal cell carcinoma (57%), hepatocellular carcinoma (40%), gastric cancer (36%), melanoma (34%), and ...
Kulaberoglu, Yavuz; Lin, Kui; Holder, Maxine; Gai, Zhongchao; Gomez, Marta; Assefa Shifa, Belul; Mavis, MerdiyeHoa, LilySharif, Ahmad ADLujan, CeliaSmith, Ewan StBjedov, IvanaTapon, NicolasWu, GengHergovich, Alexander et al. (2017-09-25) ...
Ovarian Cancer News ; Daily Ovarian Cancer updates from hundreds of medical resources. Ovarian Cancer digests, journals, abstracts, breaking news, clinical trials, research, genetics,new drugs, trials, Chemotherapy, In the News drugs on the Horizon, daily updates on Ovarian Cancer information & Medical news. Resources. Blog Keeper; Khrissy Lupinacci Diagnosed 3/06/02 at age 38 with stage 3 C Clear Cell Ovarian Cancer. [email protected] ...
Ovarian Cancer News ; Daily Ovarian Cancer updates from hundreds of medical resources. Ovarian Cancer digests, journals, abstracts, breaking news, clinical trials, research, genetics,new drugs, trials, Chemotherapy, In the News drugs on the Horizon, daily updates on Ovarian Cancer information & Medical news. Resources. Blog Keeper; Khrissy Lupinacci Diagnosed 3/06/02 at age 38 with stage 3 C Clear Cell Ovarian Cancer. [email protected] ...
I am a 57 year old woman diagnosed with Stage 1c clear cell ovarian cancer. My doctor is recommending 3 cycles of carbo/taxol. Im concerned that 6 cycles would be better, particularly since it is cl...
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
Primary signet cell carcinoma of the prostate is a rare histological variant of prostate malignancies. It is commonly originated from the stomach, colon, pancreas, and less commonly in the bladder. Prognosis of the classical type is worse than the adenocarcinoma of the prostate. Primary signet cell adenocarcinoma is diagnosed by eliminating the adenocarcinomas of other organs such as gastrointestinal tract organs. In this case report, we present a case with primary signet cell adenocarcinoma of the prostate who received docetaxel chemotherapy because of short prostate specific antigen doubling time ...
Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high ARID1A mutation rates. Here we present a mutant mouse model o...
Gynecological malignancies (ovarian clear cell and endometrioid carcinomas, endometrial serous, endometrioid and clear cell carcinomas) harbor somatic mutations in the gene PPP2R1A, the scaffolding subunit of the serine/threonine protein phosphatase 2A (PP2A) complex. The PP2A complex is composed of an A (scaffold), C (catalytic) subunit, and different B (regulatory) subunits. The PPP2R1A mutations are proposed to play a role in PP2A B-subunit binding, and thus formation of a functional PP2A phosphatase complex. The aim of this study is to determine how PPP2R1A mutations affect the binding of B-subunits and other novel interactions within the context of ovarian and endometrial carcinomas.. The ovarian clear cell line RMG2 and endometrial carcinoma cell lines Hec-1-A and Hec50 all harbor PPP2R1A mutations. The mismatch repair deficient cell line Hec-1-A express a PPP2R1A W257L heterozygous mutation; therefore somatic cell knockout technology was used to generate isogenic PPP2R1A clones that ...
To identify proteins involved in ovarian clear cell carcinoma (OCCCa), shotgun proteomics analysis was applied using formalin-fixed and paraffin-embedded samples of ovarian carcinoma. Analysis of 1521 proteins revealed that 52 were differentially expressed between four OCCCa and 12 non-OCCCa samples. Of the highly expressed proteins in OCCCa, we focused on left-right determination factor (LEFTY), a novel member of the transforming growth factor-β superfamily. In 143 cases of ovarian epithelial carcinoma including 99 OCCCas and 44 non-OCCCas, LEFTY expression at both mRNA and protein levels was significantly higher in OCCCas compared with non-OCCCas, with the mRNA expression of LEFTY1 being predominant compared to that of LEFTY2 ...
臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of NTU Repository with Academic Hub to form NTU Scholars.. ...
Source:http://linkedlifedata.com/resource/umls/id/C0279661 NCI: An adenocarcinoma arising from the pancreas. It is characterized by the presence of relatively uniform malignant cells which form acinar patterns. It usually occurs during adulthood. Signs and symptoms include abdominal pain, weight loss, nausea, and diarrhea. It may metastasize to regional lymph nodes and the liver. A minority of patients develop lipase hypersecretion syndrome. This syndrome may be seen in patients with liver metastases and it is characterized by excessive secretion of lipase in the serum, polyarthralgia, and subcutaneous fat necrosis. ...
The cohort included 110 patients with a total of 121 masses. The mean tumor size was 2.4 cm, and 50% of the lesions were clear cell carcinoma.. The mpMRI studies were performed on both 1.5-tesla and 3-tesla MRI scanners at several institutions. Sequences included T2-weighted, axial chemical shift T1-weighted, and dynamic contrast enhanced T1-weighted imaging. Because diffusion-weighted MR images were routinely acquired at UT Southwestern -- but not always at other facilities -- the researchers did not evaluate results using that sequence (Journal of Urology, October 2017, Vol. 198:4, pp. 780-786).. Seven radiologists independently reviewed the results; the radiologists had different levels of experience and were blinded to the final pathology findings. Their task was to rank the likelihood of clear cell carcinoma on a six-point scale, with 1 as definitely not cancer and 5 as definitely cancer.. By setting a parameter score of 4 or greater for clear cell carcinoma, the researchers achieved ...
BARRETA, AMILCAR... Immunohistochemistry expression of targeted therapies biomarkers in ovarian clear cell and endometrioid carcinomas (type I) and endometriosis. HUMAN PATHOLOGY 85 n. p. 72-81 MAR 2019. Journal article.
The researchers genetically engineered a strain of mice to make either Myc or another cancer-associated protein called Ras in the proximal tubules of the kidney when a compound called doxycycline, which had been added to their drinking water, was removed from it. (Myc and Ras are not normally produced at high levels by these cells.) Ras-producing mice did not get cancer. But within just a few weeks, the mice that made Myc developed kidney cancers that mimicked an aggressive subset of human renal cell adenocarcinoma that originates in the kidneys collecting ducts. Adding doxycycline back to the animals water caused the tumors to shrink dramatically.. The researchers then turned to a new tissue analysis technique called desorption electrospray ionization mass-spectrometric imaging, or DESI-MSI, recently developed by postdoctoral scholar Livia Eberlin, PhD, in the Zare laboratory to compare cancerous and normal tissue.. DESI-MSI creates a highly detailed, two-dimensional map of the chemical ...
Bašić-Jukić, Nikolina and Hudolin, Tvrtko and Radić-Antolić, Margareta and Ćorić, Marijana and Zadro, Renata and Kaštelan, Željko and Pasini, Josip and Bandić-Pavlović, Daniela and Kes, Petar (2011) Bone morphogenetic protein-7 expression is down-regulated in human clear cell renal carcinoma. Journal of Nephrology, 24 (1). pp. 91-97. ISSN 1121-8428 Bilić, Marija and Munjas-Samarin, Radenka and Ljubanović, Danica and Horvatić, Ivica and Galešić, Krešimir (2011) Effects of ramipril and valsartan on proteinuria and renal function in patients with nondiabetic proteinuria. Collegium Antropologicum, 35 (4). pp. 1061-6. ISSN 0350-6134 ...
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These tumours are frequently low grade, associated with oestrogen exposure, and present at a less advanced stage. Endometroid adenocarcinomas show a variety of appearances depending on grade. Most are well-differentiated, showing glandular structures without intervening stroma. There is little atypia of cells and extracellular mucin may be present. Areas of squamous differentiation may be present. Higher grade tumours may have bizzare cells present; it is important to ensure that serous or clear cell carcinomas are not present. Higher grade lesions show less defined architecture.. ...
Endometrioid adenocarcinoma no [18] Mesonephric adenocarcinoma [18] Clear cell adenocarcinoma no [16][17][18] ... Micrograph of a small-cell carcinoma showing cells with nuclear moulding, minimal amount of cytoplasm and stippled chromatin. ... Micrograph showing the yolk sac component of a mixed germ cell tumour. H&E stain. ... a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears ...
Association with clear cell adenocarcinoma in diethylstilbestrol-exposed offspring". Cancer. 54 (5): 869-875. doi:10.1002/1097- ... It is sometimes considered a precancerous lesion, given clear-cell adenocarcinoma patients present these lesions in close ... "Adenocarcinoma of the vagina in adolescence.A report of 7 cases including 6 clear-cell carcinomas (so-called mesonephromas)". ... Relationship to genital tract clear cell adenocarcinoma and vaginal adenosis in daughters". American Journal of Obstetrics and ...
... cancers such as clear cell adenocarcinomas; cervical ridges and hoods; and development of a cockscomb cervix appearance, which ... while the ectocervix is covered with multiple layers of cells topped with flat cells. The two types of epithelia meet at the ... The endocervical mucosa is about 3 mm (0.12 in) thick and lined with a single layer of columnar mucous cells. It contains ... The cervical canal is a passage through which sperm must travel to fertilize an egg cell after sexual intercourse. Several ...
Adenocarcinoma is more likely to spread to the lungs and lymph nodes. Clear cell adenocarcinoma occurs in a small percentage of ... squamous-cell carcinoma and adenocarcinoma. Squamous-cell carcinoma of the vagina arises from the squamous cells (epithelium) ... Approximately one in 1,000 (0.1%) DES Daughters will be diagnosed with clear cell adenocarcinoma. The risk is virtually non- ... Vaginal adenocarcinoma arises from the glandular (secretory) cells in the lining of the vagina. ...
2008). "Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma". ... Cell. Biol. 29 (1): 20-30. doi:10.1128/MCB.00544-08. PMC 2612482 . PMID 18936159. Wang Y, Fu W, Xie F, et al. (2010). "Common ... Cell Genet. 66 (2): 96-8. doi:10.1159/000133675. PMID 8287691. Guey LT, García-Closas M, Murta-Nascimento C, et al. (2010). " ... 2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell ...
"Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses ... expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of ... "Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells ...
... of class III beta-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma". Clinical ... However, there are also data in clear cell carcinoma, melanoma and breast cancer showing favorable prognosis. Class III β- ... Cell. 140 (1): 74-87. doi:10.1016/j.cell.2009.12.011. PMC 3164117. PMID 20074521. André N, Braguer D, Brasseur G, Gonçalves A, ... Class III β-tubulin's role in neural development has warranted its use as an early biomarker of neural cell differentiation ...
On histology, the tumors consist of adenocarcinoma (endometrioid, serous or clear cell) mixed with the malignant mesenchymal ( ... or that the tumor is the result of a stem cell that differentiates into different cell types (the "combination" theory). " ... first from a stem cell into a population of cells, that then differentiates into epithelial and stromal components. There is ... As with endometrial carcinomas, the prognosis is influenced by the grade and type of the adenocarcinoma, being poorest with ...
Subsequent studies have shown an approximate 40-fold increased risk of vaginal/cervical clear cell adenocarcinoma in women ... who had been diagnosed with vaginal clear cell adenocarcinoma had been exposed prenatally to DES. ... which means a type of cell normally found in the uterus, columnar cells, are also present in the vagina), an increased cervical ... Daughters exposed to DES in utero may also have an increased risk of moderate to severe cervical squamous cell dysplasia and an ...
Other tumors not classified include eccrine ductal carcinoma, basaloid eccrine carcinoma, clear cell eccrine carcinoma and non- ... and ductal papillary adenocarcinoma. Benign tumors include poroma, hidradenoma, spiradenoma, cylindroma, syringometaplasia, ...
... in the 1950s found that women who were exposed to DES were at increased risk for cervical and vaginal clear cell adenocarcinoma ... of diethylstilbestrol and its methyl ethers on aneuploidy induction and microtubule distribution in Chinese hamster V79 cells ...
DES has been linked to a variety of long-term adverse effects, such as increased risk of vaginal clear-cell adenocarcinoma, ... University of Chicago DES Registry of patients with CCA (clear cell adenocarcinoma) of the vagina and/or cervix ... published in the New England Journal of Medicine showed a probable link between DES and vaginal clear cell adenocarcinoma in ... DES was shown to cause clear-cell carcinoma, a rare vaginal tumor, in girls and women who had been exposed to this medication ...
... and clear cell renal cell cancer in which high tissue IGFBP-3 expression has been linked to poor prognostic features or patient ... significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma". ... IGFBP-3 also interacts with cell-surface proteins, affecting cell signaling from outside the cell or after internalization, and ... "Altered expression of members of the IGF-axis in clear cell renal cell carcinoma". Int. J. Oncol. 26 (4): 923-31. doi:10.3892/ ...
... when the prenatal exposition has been linked to the clear-cell adenocarcinoma of the vagina. Following studies showed elevated ... Male germ cells mutate at a much faster rate than female germ cells, and as the father ages, the DNA of the germ cells mutates ... This is because, as humans age, male germ cells acquire mutations at a much faster rate than female germ cells. Around a 5% ... Cigarette smoke acts as a chemical mutagen on germ cell DNA. The germ cells suffer oxidative damage, and the effects can be ...
... as well as the more aggressive uterine papillary serous carcinoma and uterine clear-cell carcinoma. Endometrial stromal ... These include the common and readily treatable well-differentiated endometrioid adenocarcinoma, ... Estrogen receptors, known to be present on the surfaces of the cells of this type of cancer, are thought to interact with the ... Endometrial carcinomas originate from cells in the glands of the endometrium (uterine lining). ...
Clear-cell adenocarcinomas are histopathologically similar to other clear cell carcinomas, with clear cells and hobnail cells. ... They are typically early-stage and therefore curable by surgery, but advanced clear-cell adenocarcinomas (approximately 20%) ... Usually, when cells grow old or get damaged, they die, and new cells take their place. Cancer starts when new cells form ... Germ cell tumors of the ovary develop from the ovarian germ cells. Germ cell tumor accounts for about 30% of ovarian tumors, ...
Hobnail cells are found in clear cell ovarian adenocarcinoma, collecting duct carcinoma, and in end-stage cirrhosis. Kumar, ... In histopathology, a hobnail cell is a cell with a characteristic appearance, including a bulbous nucleus and nuclear ...
... clear cell kidney carcinoma, breast ductal carcinoma, renal cell carcinoma, cervical cancer (squamous), colon adenocarcinoma, ... Renal cell carcinoma (Focus on but not limited to clear cell subtype) European Union/United Kingdom: Breast Cancer - ER+ve, ... pancreatic ductal adenocarcinoma, acute myeloid leukemia, prostate adenocarcinoma, lung adenocarcinoma, cutaneous melanoma, ... stomach adenocarcinoma, rectal carcinoma, hepatocellular carcinoma, Head and neck (oral) squamous cell carcinoma, thyroid ...
Signet ring/round clear cells [6]. *GI stromal tumor (Krukenberg)[6]. Molecular biology[edit]. The cytokeratins are encoded by ... Adenocarcinomas originating from those above[6]. Cytokeratin 10 *Keratinized stratified epithelium. *Differentiated areas of ... Cytokeratins interact with desmosomes and hemidesmosomes, thus collaborating to cell-cell adhesion and basal cell-underlying ... Cell Biol. 8 (7): 562-73. doi:10.1038/nrm2197. PMID 17551517.. *^ Franke WW, Schmid E, Osborn M, Weber K (June 1979). " ...
Clear-cell carcinoma also known as clear cell adenocarcinoma and mesonephroma is an epithelial cell derived carcinoma ... Clear-cell colorectal carcinoma) or ovary (Clear-cell ovarian carcinoma) . Treatment options for clear cell carcinoma vary by ... Clear-cell carcinoma may arise in multiple tissue types including the kidney (Clear-cell renal carcinoma), uterus (Uterine ... and surgical resection in ovarian clear cell; debulking or resection paired with chemotherapy (cisplatin) in ovarian clear cell ...
... pale cell acanthoma) Clear cell squamous cell carcinoma (clear cell carcinoma of the skin) Chronic scar keratosis (chronic ... Adenoid squamous cell carcinoma (pseudoglandular squamous cell carcinoma) Aggressive digital papillary adenocarcinoma (digital ... Solitary trichoepithelioma Spindle cell squamous cell carcinoma (spindle cell carcinoma) Spiradenoma Squamous cell carcinoma ... Aberrant basal cell carcinoma Acanthoma fissuratum (granuloma fissuratum, spectacle frame acanthoma) Acrospiroma (clear cell ...
Bichler, who at 17 had developed clear cell adenocarcinoma of the cervix and vagina requiring the removal of her reproductive ...
... carcinoma Adenoid cystic carcinoma Polymorphous low-grade adenocarcinoma Epithelial-myoepithelial carcinoma Clear cell ... not otherwise specified Basal cell adenocarcinoma Sebaceous carcinoma Sebaceous lymphadenocarcinoma Cystadenocarcinoma Low- ... Biopsy: The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer ... tissue tumors Hemangioma Hematolymphoid tumors Hodgkin lymphoma Diffuse large B-cell lymphoma Extranodal marginal zone B cell ...
... clear-cell sarcoma, including clear-cell sarcoma of the kidney clear-cell carcinoma, all/mostly clear-cell adenocarcinoma This ... Clear-cell tumor (any with Clear cells) can refer to: ... page lists articles associated with the title Clear-cell tumor ...
... is medical jargon for cirrhosis of the liver Cellular morphology pathognomonic for clear cell adenocarcinoma of the ovary This ...
... was found to be causing an incredibly rare vaginal cancer known as clear-cell adenocarcinoma in young girls when the cancer was ...
... pancreatic adenocarcinoma and kidney renal clear cell carcinoma. In a systemic analysis, cancer-specific pathways were found to ... The increased enrichment of immune signature reflects the expression of cells including T cells, cytotoxic T cells, Th-1 cells ... by antigen-presenting cells (APCs). CXCR3 expressing Th1-polarized CD4 T cells and cytotoxic T cells are recruited to the site ... Antigen-activated T cells secrete CCR5 ligands (CCL2 and CCL3) to recruit natural killer (NK) cells and other innate immune ...
... clear cell adenocarcinoma - clear-cell sarcoma - clear cell sarcoma of the kidney - clinical breast exam - clinical resistance ... cell - cell differentiation - cell motility - cell proliferation - cell respiration - cell adhesion - cellular adoptive ... systemic therapy T cell - T-3 - T-cell depletion - T-cell lymphoma - T138067 - T4N5 liposomal lotion - T900607 - TAC-101 - ... basal cell - basal cell carcinoma - basal cell nevus syndrome - basophil - batimastat - BAY 12-9566 - BAY 43-9006 - BAY 56-3722 ...
... clear cell adenocarcinoma) of the vagina and/or cervix DES Diethylstilbestrol Provides resources and social media links for ... such as increased risk of vaginal clear-cell adenocarcinoma vaginal adenosis T-shaped uterus uterine fibroids cervical weakness ... In 1971, DES was shown to cause clear-cell carcinoma, a rare vaginal tumor, in girls and women who had been exposed to this ... In 1971, a report published in the New England Journal of Medicine showed a probable link between DES and vaginal clear cell ...
The tumour cells themselves typically have abundant clear to pale pink cytoplasm containing abundant glycogen, which is ... Adenocarcinoma. *High-grade prostatic intraepithelial neoplasia *HGPIN. *Small-cell carcinoma. *Transitional cell carcinoma ... A seminoma is a germ cell tumor of the testicle or, more rarely, the mediastinum or other extra-gonadal locations. It is a ... Weidner N (February 1999). "Germ-cell tumors of the mediastinum". Seminars in Diagnostic Pathology. 16 (1): 42-50. PMID ...
Although cholangiocarcinoma is known to have the histological and molecular features of an adenocarcinoma of epithelial cells ... a majority of people undergo exploratory surgery unless there is already a clear indication that the tumor is inoperable.[12] ... The disease is confirmed by examination of cells from the tumor under a microscope.[4] It is typically an adenocarcinoma (a ... Micrograph of an intrahepatic cholangiocarcinoma (right of image) adjacent to normal liver cells (left of image). H&E stain. ...
The LNCaP cancer cell line was established from a human lymph node metastatic lesion of prostatic adenocarcinoma. PC-3 and DU- ... Early prostate cancer usually has no clear symptoms. Sometimes prostate cancer does cause symptoms, often similar to those of ... 145 cells were established from human prostatic adenocarcinoma metastatic to bone and to brain, respectively. LNCaP cells ... lo Prostate Cancer Cell Population Harbors Self-Renewing Long-Term Tumor-Propagating Cells that Resist Castration". Cell Stem ...
... miR-9 methylation status is associated with cancer development and metastatic recurrence in patients with clear cell renal cell ... "Regulation of the transcription factor NF-kappaB1 by microRNA-9 in human gastric adenocarcinoma". Mol Cancer. 9 (1): 16. doi: ... Uchida N (2010). "MicroRNA-9 controls a migratory mechanism in human neural progenitor cells". Cell Stem Cell. 6 (4): 294-6. ... "MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors". Cell Stem Cell. 6 ...
Non-small-cell lung carcinoma. *Squamous-cell carcinoma. *Adenocarcinoma (Mucinous cystadenocarcinoma). *Large-cell lung ... Histologically, it forms clusters of goblet cells containing mucin with a minor admixture of Paneth cells and endocrine cells. ... Goblet cell carcinoid[edit]. Main article: Goblet cell carcinoid. This is considered to be a hybrid between an exocrine and ... Carcinoid (also carcinoid tumor) is a slow-growing[1] type of neuroendocrine tumor originating in the cells of the ...
In the 1990s and 2000s the roles of antibodies in the condition became more clear. SPS patients generally have GAD antibodies, ... Hematopoietic stem cell transplantation (HSCT) with high intensity conditioning protocol has been performed in a few cases with ... Paraneoplastic SPS with amphiphysin antibodies and breast adenocarcinoma tend to occur together. These patients tend not to ... There is a limited but encouraging therapeutic experience of hematopoietic stem cell transplantation for SPS. ...
Historically, adenocarcinoma was more often seen peripherally in the lungs than small cell lung cancer and squamous cell lung ... In addition, during repair of DNA double-strand breaks, or repair of other DNA damages, incompletely cleared sites of repair ... Lung adenocarcinoma[edit]. Main article: Adenocarcinoma of the lung. Adenocarcinoma of the lung is currently the most common ... Large-cell lung carcinoma[edit]. Main article: Large-cell lung carcinoma. Large cell lung carcinoma (LCLC) is a heterogeneous ...
Squamous-cell carcinoma of the vagina. *Botryoid rhabdomyosarcoma. *Clear cell adenocarcinoma of the vagina ...
Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma ... It is not clear whether the mechanisms causing isolated oral LP are different from those causing oral LP with cutaneous LP. An ... Chemokines are produced by activated CD8+ T cells that attract additional inflammatory cells, thereby promoting continued ... The inflammatory infiltrate in oral LP is primarily composed of CD8+ T cells. A potential pathway for CD8+ T cell-mediated ...
Refers to a mixed tumor containing both adenocarcinoma and squamous cell carcinoma, wherein each of these cell types comprise ... Non-hematopoietic mesenchymal cells ⇨ sarcoma. *Hematopoietic cells *Bone marrow-derived cells that normally mature in the ... Composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.. Small cell carcinoma. Cells ... Certain combinations of mutations in the given progenitor cell ultimately result in that cell (also called a cancer stem cell) ...
However, CE can be used for diagnosing T-cell lymphoma, ulcerative jejunoileitis and adenocarcinoma in refractory or ... Whether or not a gluten-free diet brings this risk back to baseline is not clear.[39] Long-standing and untreated disease may ... α-gliadin stimulates membrane cells, enterocytes, of the intestine to allow larger molecules around the sealant between cells. ... Dewar D, Pereira SP, Ciclitira PJ (2004). "The pathogenesis of coeliac disease". Int J Biochem Cell Biol. 36 (1): 17-24. doi: ...
... a synthetic estrogen used from the 1940s to 1971 when the prenatal exposition has been linked to the clear-cell adenocarcinoma ... Male germ cells mutate at a much faster rate than female germ cells, and as the father ages, the DNA of the germ cells mutates ... This is because, as humans age, male germ cells acquire mutations at a much faster rate than female germ cells.[59][32][29] ... Cigarette smoke acts as a chemical mutagen on germ cell DNA. The germ cells suffer oxidative damage, and the effects can be ...
... cancers such as clear cell adenocarcinomas; cervical ridges and hoods; and development of a cockscomb cervix appearance.[56] ... while the ectocervix is covered with multiple layers of cells topped with flat cells. The two types of epithelia meet the ... The cervical canal is a passage through which sperm must travel to fertilize an egg cell after sexual intercourse. Several ... The endocervical mucosa is about 3 millimetres (0.12 in) thick, lined with a single layer of columnar mucous cells, and ...
Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma ... The cause is not entirely clear,[2] but is thought to be multifactorial.[6] It has been suggested that aphthous stomatitis is ... The relative increase in percentage of CD8+ T cells, caused by a reduction in numbers of CD4+ T cells may be implicated in RAS- ... Mast cells and macrophages are also involved, secreting TNF-α along with the T cells. When early aphthous ulcers are biopsied, ...
... when the prenatal exposition has been linked to the clear-cell adenocarcinoma of the vagina. Following studies showed elevated ... Male germ cells mutate at a much faster rate than female germ cells, and as the father ages, the DNA of the germ cells mutates ... This is because, as humans age, male germ cells acquire mutations at a much faster rate than female germ cells.[29][32][60] ... Cigarette smoke acts as a chemical mutagen on germ cell DNA. The germ cells suffer oxidative damage, and the effects can be ...
medulloblastoma] ,1%; Liver hepatoblastoma 1.6%; Bile ducts adenocarcinoma Low but increased; Stomach adenocarcinoma ,1% in ... to APC-mutated cells are much more likely to lead to cancer than they would in non-mutated epithelial cells. ... Absence of polyps does not 'clear' a person, as polyps can develop later in life; also a few polyps over time are not that ... Even with the flawed gene, it may still take time before a cell actually does develop that is cancerous as a result, and the ...
The three main subtypes of NSCLC are adenocarcinoma, squamous-cell carcinoma and large-cell carcinoma.[1] ... the effect of smoking cannabis on lung cancer risk is not clear.[36][37] A 2013 review did not find an increased risk from ... implicated stem cells include club cells and neuroepithelial cells that express club cell secretory protein. Small-cell lung ... Non-small-cell lung carcinoma[edit]. Micrograph of squamous-cell carcinoma, a type of non-small-cell carcinoma, FNA specimen, ...
Clear cell adenocarcinoma. *Apudoma. *Cylindroma. *Papillary hidradenoma. Adnexal and. skin appendage (8390-8429). *sweat gland ... Somatostatinoma is a malignant tumor of the delta cells of the endocrine pancreas that produces somatostatin. Increased levels ...
Within the class of medications, there is no clear evidence that one agent works better than another.[1][2] ... Micrograph of the gastric antrum showing G cell hyperplasia, a histomorphologic change seen with PPI use (H&E stain) ... For example, although they reduce the incidence of esophageal adenocarcinoma in Barrett's oesophagus,[12] they do not change ... The PPIs are given in an inactive form, which is neutrally charged (lipophilic) and readily crosses cell membranes into ...
Clear cell adenocarcinoma. *Apudoma. *Cylindroma. *Papillary hidradenoma. Adnexal and. skin appendage (8390-8429). *sweat gland ... Cells resemble normal hepatocytes and are traversed by blood vessels but lack portal tracts or central veins. ... The hepatocytes are on a regular reticulin scaffold and less or equal to three cell thick. ... because of the risk of rupture causing bleeding and because they may contain malignant cells.[8] Current recommendations are ...
Adenocarcinoma. *Aggressive digital papillary adenocarcinoma. *Extramammary Paget's disease. Ungrouped. *Merkel cell carcinoma ... Solivan, GA; Smith, KJ; James, WD (1990). "squamous cell carcinoma". Journal of the American Academy of Dermatology. 23 (5 Pt 2 ... The incidence of squamous cell carcinoma increases to 37% when the cutaneous horn is present on the penis.[3] Tenderness at the ... Malignancy is present in up to 20% of cases, with squamous cell carcinoma being the most common type. ...
... beta cells, delta cells, and PP cells, each of which releases a different hormone. These cells have characteristic positions, ... Ryan DP, Hong TS, Bardeesy N (September 2014). "Pancreatic adenocarcinoma". N. Engl. J. Med. 371 (11): 1039-49. doi:10.1056/ ... However the incidence of these cancers has been rising sharply; it is not clear to what extent this reflects increased ... acinar cells, endocrine cells, and ductal cells. These progenitor cells are characterised by the co-expression of the ...
Clear cell adenocarcinoma(英语:Clear cell adenocarcinoma). *Apudoma(英语:Apudoma) ... Acinar(英语:Acinus) cell (8550-8559). *Acinic cell carcinoma(英语:Acinic cell carcinoma) ... 印戒细胞癌(Signet ring cell carcinoma,SRCC),又称黏液细胞癌(mucinous cell carcinoma,MCC)是上皮组织的恶性肿瘤,组织学外观特点是可以见到印戒细胞。 ... Early diagnosis of signet ring cell carcinoma of the stomach
It is not clear if sunscreen affects the risk of basal-cell cancer.[7] Nonmelanoma skin cancer is usually curable.[5] Treatment ... Adenocarcinoma. *Aggressive digital papillary adenocarcinoma. *Extramammary Paget's disease. Ungrouped. *Merkel cell carcinoma ... are basal-cell cancers and 20% squamous-cell skin cancers.[11] Basal-cell and squamous-cell skin cancers rarely result in death ... Tumor cells transform into keratinized squamous cells and form round nodules with concentric, laminated layers, called "cell ...
... has been found to accumulate to higher concentration in ovarian adenocarcinoma cells than kidney carcinoma cells, ... The solution is a clear brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.[14] 20 mg Taxotere is ... it is cytotoxic to all dividing cells in the body.[23] This includes tumour cells as well as hair follicles, bone marrow and ... Common side effects include hair loss, cytopenia (low blood cell counts), numbness, shortness of breath, vomiting, and muscle ...
Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma ... Chewable aspirin tablets should be swallowed, with the residue quickly cleared from the mouth.[citation needed] ... Cytotoxic drugs administered during chemotherapy target cells with fast turnovers such as malignant cells. However, the ... Only the superficial epithelial cells of the epidermis or of the mucosa are lost, and the lesion can reach the depth of the ...
... which collectively represent the majority of the non-adenocarcinomas, can also arise from these cells.[6] One to two percent of ... One particular feature that is evaluated is the encouraging presence, or discouraging absence, of a clear layer or plane of fat ... The next most common type, acinar cell carcinoma of the pancreas, arises in the clusters of cells that produce these enzymes, ... The pancreas has many functions, served by the endocrine cells in the islets of Langerhans and the exocrine acinar cells. ...
Clear cell adenocarcinoma. *Apudoma. *Cylindroma. *Papillary hidradenoma. Adnexal and. skin appendage (8390-8429). *sweat gland ... Microscopic appearance is signet ring cell carcinoma, which is tumor cells with mucin droplet that displaces the nucleus to one ... Diffuse stomach cancer is characterized by the presence of poorly differentiated tumor cells. ... rigid stomach wall caused by diffuse infiltration of tumor cells and extensive fibrosis. ...
... Thouraya Achach,1 Soumaya Rammeh,1 Amel Trabelsi,1 Rached ... Sara C. Shalin, Andrea L. Haws, Dornechia G. Carter, and Neda Zarrin-Khameh, "Clear cell adenocarcinoma arising from ... Harutake Sawazaki, Hirofumi Goto, Noriyasu Takao, Yoji Taki, and Hideo Takeuchi, "Clear Cell Adenocarcinoma Arising From ... "Clear cell adenocarcinoma arising from abdominal wall endometriosis," Cirugía y Cirujanos (English Edition), 2016. View at ...
Adenocarcinoma. Adenocarcinoma, Clear Cell. Cystadenoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. ... Clear cell carcinoma. Paclitaxel-platinum. Chemotherapy. response to chemotherapy. survival of clear cell ovarian carcinoma. ... Clear cell carcinoma comprises 5-10% of surface epithelial ovarian cancers, and about 30-40% of the patients with clear cell ... Ovarian Clear Cell Adenocarcinoma Review (OCCA). The safety and scientific validity of this study is the responsibility of the ...
Clear-cell adenocarcinoma of the vagina Clear-cell ovarian carcinoma Uterine clear-cell carcinoma Clear-cell adenocarcinoma of ... Clear-cell adenocarcinoma is a type of adenocarcinoma that shows clear cells. Types include: ... which is a type of Clear-cell carcinoma of the lung) Clear-cell sarcoma "NCI Dictionary of Cancer Terms". National Cancer ...
"Clear cell adenocarcinoma of the colon arising in endometriosis: a rare variant of primary colonic adenocarcinoma," Journal of ... C. A. Rubio, "Clear cell adenocarcinoma of the colon," Journal of Clinical Pathology, vol. 48, no. 12, pp. 1142-1144, 1995. ... Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature. Christian Daniel Barrera-Maldonado,1 ... K. Soga, H. Konishi, N. Tatsumi et al., "Clear cell adenocarcinoma of the colon: a case report and review of literature," World ...
DES daughters should have a pap/pelvic exam every year because of their lifelong risk for clear-cell adenocarcinoma. Clear-cell ... Clear-cell adenocarcinoma (CCA) of the vagina or cervix is a rare adenocarcinoma often linked to prenatal exposure to ... Clear cell adenocarcinoma entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain ... Some of the main signs and symptoms for clear-cell adenocarcinoma of the vagina are spotting between menstrual cycles, bleeding ...
Every Step of the Way, a Wide Range of Cell Health Products. Maintaining healthy cells is the key to experimental success and ... weve highlighted the technologies and products within cell biology that are critical to maintaining optimal cell health. No ... To give you confidence in the health of your cells every step of the way, ... matter how you are using your cells, you can count on these products to help keep them healthy. ...
Clear Cell including probable outcomes, duration, recurrence, complications, deaths, and survival rates. ... Symptoms: Adenocarcinoma, Clear Cell *Complications: Adenocarcinoma, Clear Cell *Treatments: Adenocarcinoma, Clear Cell About ... See also complications of Adenocarcinoma, Clear Cell. Adenocarcinoma, Clear Cell: Research More. *Adenocarcinoma, Clear Cell: ... Clear Cell usually refers to the likely outcome of Adenocarcinoma, Clear Cell. The prognosis of Adenocarcinoma, Clear Cell may ...
The histopathology of tumor cells showed features with abundant clear cytoplasm and prominent cell boundaries. ... Primary clear cell carcinoma of pancreas is extremely rare. We present a case of a 64-year-old male with a mass in the distal ... The patient was subsequently diagnosed with a primary clear cell carcinoma of the pancreas. This is the first time we have ... Immunohistochemical analysis of neoplastic cells showed reactions to antibodies against cytokeratin-7 and showed no reactions ...
Associations diethylstilbestrol exposure References Ahrens WA, Barron-Rodriguez LP, McKee M, Rivkees S, Reyes-Mugica M. Clear ... Ahrens WA, Barron-Rodriguez LP, McKee M, Rivkees S, Reyes-Mugica M. Clear Cell Adenocarcinoma of the Cervix in a Child without ... Home , E. Pathology by systems , Reproductive system , Female genital system , Uterus , Uterine cervix , cervical clear cell ...
Non-clear-cell adenocarcinoma Vagina MeSH Terms expand_less. expand_more. Adenocarcinoma Aged Basophils Cellular Structures ... The adenocarcinoma did not appear to be associated with vaginal adenosis. It lacked clear cell component and interestingly ... A case of primary non-clear-cell adenocarcinoma of the vagina is reported occurring in a 65-year-old woman without exposure to ... Primary Non-clear-cell Adenocarcinoma of the Vagina: Report of a Case. ...
A Case of Clear Cell Adenocarcinoma Arising in the Endometriosis of the Rectum Treated by Laparoscopic Surgery. Yu Okazawa, ... We report a very rare case of clear cell adenocarcinoma arising from endometriosis of the rectum. An 83-year-old woman was ... Histopathological examination revealed an adenocarcinoma, similar to clear cell carcinoma of the ovary, invading the subserosa ... Endometrioid adenocarcinoma arising from ectopic endometriosis is very rare, and was first described by Marx in 1949. Including ...
Urethral cancer is a rare malignancy with urothelial subtype being the most common followed by adenocarcinoma. In women, the ... Clear cell adenocarcinoma of the urethra with inguinal lymph node metastases: A rare case report and review of literature April ... Clear cell variety of adenocarcinoma is a rarer entity which usually has a better prognosis than other variants. Lymph node ... The detailed evaluation revealed clear cell adenocarcinoma of the urethra as the primary with lymph node metastasis. ...
Long-Term Follow-up of Women With DES-Related Vaginal and Cervical Clear Cell Adenocarcinoma. By Matthew Stenger and compiled ... Patients with clear cell adenocarcinoma had greater mortality risk across their life span. Compared with the general U.S. ... women with DES-related clear cell adenocarcinoma are aging into their 50s and 60s, but the effect of this condition across ... risk of death among women with DES-related clear cell adenocarcinoma was 27 times higher for women aged between 10 and 34 years ...
... ovarian clear cell adenocarcinoma clinical trials [3]. Trials Investigating Ovarian Clear Cell Adenocarcinoma by Gene and ... ovarian clear cell adenocarcinoma clinical trials. Drugs Being Investigated in Ovarian Clear Cell Adenocarcinoma Trials by ... There are 16 clinical trials for ovarian clear cell adenocarcinoma, of which 14 are open and 2 are completed or closed. Of the ... Of the trial that contains ATM status and ovarian clear cell adenocarcinoma as inclusion criteria, 1 is phase 1 (1 open) [3]. ...
... clear cell adenocarcinoma of the ovaryLow expression of S100P is associated with poor prognosis in patients with clear cell ... adenocarcinoma of the ovary. 卵巣明細胞腺癌においてS100P発現低
Ovarian clear cell adenocarcinoma (OCCA) is recognized as a distinct histological type of cancer, and its frequency among ... Clear cell carcinoma has an expression pattern of cell cycle regulatory molecules that is unique among ovarian adenocarcinomas ... Promoter Methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma. Zeitschrift:. Molecular ... Kennedy AW, Biscotti CV, Hart WR, Webster KD: Ovarian clear cell adenocarcinoma. Gynecol Oncol. 1989, 32: 342-349. 10.1016/0090 ...
Mixed Serous and Clear Cell Adenocarcinoma of the Ovary Presenting with Symptomatic Hypercalcemia: A Case Report and Clinical ... Mixed serous and clear cell adenocarcinoma of the ovary presenting with symptomatic hypercalcemia: A case report and clinical ... 4. Lewin S, Dezube D, Guddati A, Mittal K, Muggia F, Klein P. Paraneoplastic hypercalcemia in clear cell ovarian adenocarcinoma ... The pathologic findings were confirmed by 3 different pathologists as serous and clear cell, lacking features of small cell ...
Cancer: Clear Cell Adenocarcinoma (CCA). September 20, 2007. By Diseases & Conditions Clear cell adenocarcinoma (CCA) is a rare ... form of vaginal and cervical cancer in which the inside of the tumorous cells appear clear when viewed through a microscope. It ...
What is clear cell adenocarcinoma? Meaning of clear cell adenocarcinoma medical term. What does clear cell adenocarcinoma mean? ... Looking for online definition of clear cell adenocarcinoma in the Medical Dictionary? clear cell adenocarcinoma explanation ... clear cell prostatic adenocarcinoma, and metastatic clear cell renal cell carcinoma.. Adenocarcinoma of the urinary bladder ... Clear cell adenocarcinoma (CCA) usually arises from the female genital tract.. Clear cell adenocarcinoma of the urinary bladder ...
Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
... with multifocal bilateral choroid metastatic lesions that were found to originate from a primary clear cell adenocarcinoma of ... The aim of the present report was to draw the attention of oncologists to the importance of prompt diagnosis of primary clear ... cell adenocarcinoma of the lung, which allows early initiation of treatment to maintain quality of life. A 63-year-old Chinese ... Clear cell adenocarcinoma of the lung with an abundant clear cell component is extremely rare, and the associated biological ...
Unlike squamous cell carcinoma, clear cell adenocarcinoma manifests in patients at a very early age, usually after age 14 years ... Clear Cell Adenocarcinoma Surgery. Therapeutic considerations are very similar to those for patients with squamous cell ... Clear cell adenocarcinoma - Although the etiology is different, the presentation may be similar to that of squamous cell ... Clear cell adenocarcinoma. This is the second most common type of primary vaginal carcinoma, accounting for about 9% of all ...
Tag: Clear Cell Adenocarcinoma. Clear Cell Adenocarcinoma of the Ovary Associated with In Utero DES Exposure. A 45-year-old ... Clear Cell Adenocarcinoma, DES, DES-exposed, NCBI, United StatesLeave a comment on Genital clear cell adenocarcinoma. ... Clear Cell Adenocarcinoma, DES, DES-exposed, Endometriosis, NCBI, Ovarian Cancer2 Comments on Clear Cell Adenocarcinoma of the ... Clear Cell Adenocarcinoma, DES, DES-exposed, NCBILeave a comment on Diethylstilbestrol DES-induced clear cell adenocarcinoma of ...
In gynecologic malignancies, ovarian Clear Cell Carcinoma (CCC) is one of the most commonhistologic subtypes, whereas HHM ... Clear cell adenocarcinoma of the endometrium shows cells with clear cytoplasmand pleomorphic high-grade nuclei and the ... Endometrial curetting revealed poorly-differentiated adenocarcinoma of the endometrium, suggesting clear cell adenocarcinoma. ... 2] , two HHM cases were clear cell adenocarcinoma of uterus, whereas the cause of hypercalcemia was not identified. The case of ...
Do you qualify for these Clear Cell Adenocarcinoma studies? Were researching the most effective treatments. ... Clear Cell Adenocarcinoma clinical trials at UCSD 1 in progress, 0 open to eligible people ... paclitaxel and gemcitabine hydrochloride work in different ways to stop the growth of tumor cells, either by killing the cells ... and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether combination chemotherapy is ...
Clear cell adenocarcinoma cervix: a diagnostic dilemma. Maheshwari, Veena; Sharma, Rajyashri; Mehdi, Ghazala; Prasad, Smriti; ... Clear cell adenocarcinoma cervix: a diagnostic dilemma. ...
... vs Physicians Choice Chemotherapy in Recurrent Ovarian Clear Cell Adenocarcinoma (MOCCA)" trial is an open-label study which ... Do clear cell ovarian carcinomas have poorer prognosis compared to other epithelial cell types? A study of 1411 clear cell ... Interestingly, clear cell ovarian cancer shares more similarity in gene expression profiles with clear cell renal cell ... where clear cell cancers constitute up to 25% of diagnosed ovarian cancer.1 2 Histologically, ovarian clear cell carcinoma is ...
3A). The cells had an abundant clear or granular cytoplasm. The cells were cuboidal or columnar and hobnail cells were often ... Clear cell adenocarcinoma (CCA) of the urethra is a rare disease entity. To date, it has been described on several case reports ... Clear cell adenocarcinoma of the urethra is a rare disease entity with an uncertain histogenesis. Here, we present a case of ... The histogenesis of clear cell adenocarcinoma of the lower urinary tract: case series and review of the literature. Hum Pathol ...
Clear Cell Adenocarcinoma (CCA):. Clear Cell Carcinoma: A rare type of tumor of the female genital tract in which the inside of ... the cells look clear when viewed under a microscope.. Adenocarcinoma: A cancer that begins in cells that line certain internal ... Squamous Cells: Flat cells that look like fish scales under a microscope. These cells cover internal and external surfaces of ... Squamous Cell Carcinoma: Cancer that begins in squamous cells, which are thin, flat cells resembling fish scales. Squamous ...
  • Histopathological examination revealed an adenocarcinoma, similar to clear cell carcinoma of the ovary, invading the subserosa and no metastasis of lymph nodes. (sages.org)
  • Ho CM, Huang YJ, Chen TC, Huang SH, Liu FS, Chang Chien CC, Yu MH, Mao TL, Wang TY, Hsieh CY: Pure-type clear cell carcinoma of the ovary as a distinct histological type and improved survival in patients treated with paclitaxelplatinum-based chemotherapy in pure-type advanced disease. (springermedizin.de)
  • Sugiyama T, Kamura T, Kigawa J, Terakawa N, Kikuchi Y, Kita T, Suzuki M, Sato I, Taguchi K: Clinical characteristics of clear cell carcinoma of the ovary: a distinct histological type with poor prognosis and resistance to platinum-based chemotherapy. (springermedizin.de)
  • This case report describes symptomatic hypercalcemia as the presenting sign of mixed serous and clear cell carcinoma of the ovary. (thepermanentejournal.org)
  • To our knowledge, this patient is the first clinical case featuring clear cell adenocarcinoma of the ovary that may be linked to diethylstilbestrol exposure in utero. (desdaughter.com)
  • We would like to emphasize that clear cell adenocarcinoma of the vagina and cervix, not the ovary, were previously shown to be sites for tumors in female offspring exposed prenatally to DES. (desdaughter.com)
  • She underwent surgery and staging that revealed clear cell adenocarcinoma confined to the left ovary. (desdaughter.com)
  • This further enhances our degree of suspicion on the causality between in utero DES exposure and the clear cell adenocarcinoma of the ovary in our patient. (desdaughter.com)
  • A cell line, designated as RMG-V, was established from a patient with clear cell adenocarcinoma of the ovary. (elsevier.com)
  • Objectives: We retrospectively analyzed the clinicopathological features and evaluated the prognostic indicators of recurrence in 132 patients with clear cell adenocarcinoma (CCC) of the ovary at reproductive age. (fujita-hu.ac.jp)
  • The clinical and pathologic features of 86 cases of metastatic colorectal adenocarcinoma involving the ovary were reviewed. (semanticscholar.org)
  • These genes are widely accepted as the predisposing factors that trigger malignant transformation of the epithelial cells of the ovary. (mdpi.com)
  • Clear-cell adenocarcinoma (CCA) of the vagina or cervix is a rare adenocarcinoma often linked to prenatal exposure to diethylstilbestrol (DES), a drug which was prescribed in high-risk pregnancy. (wikipedia.org)
  • Clear-cell adenocarcinoma of the vagina is a rare cancer, occurring in up to 10% of primary vaginal malignancies. (wikipedia.org)
  • Some of the main signs and symptoms for clear-cell adenocarcinoma of the vagina are spotting between menstrual cycles, bleeding post-menopause, abnormal bleeding, and malignant pericardial effusion or cardiac tamponade. (wikipedia.org)
  • A case of primary non-clear-cell adenocarcinoma of the vagina is reported occurring in a 65-year-old woman without exposure to diethylstilbestrol(DES) in utero. (koreamed.org)
  • Primary clear cell adenocarcinomas (PCCA) most commonly involve the vagina, cervix, ovaries, and urinary tract including the kidneys. (thefreedictionary.com)
  • Cancers from distant sites that metastasize to the vagina through the blood or lymphatic system also occur, including colon cancer, renal cell carcinoma, melanoma , and breast cancer. (medscape.com)
  • Women who had prenatal exposure to diethylstilbestrol (DES) are at increased risk for clear-cell adenocarcinoma of the vagina and cervix early in life. (desdaughter.com)
  • In the late 1960s, an unusual occurrence of a rare cancer of the vagina among young women, called clear cell adenocarcinoma (CCA), was observed and subsequently linked to their exposure to DES while in the womb. (nih.gov)
  • In addition, these women are more than twice as likely to develop pre-cancerous cells in the cervix or vagina (called cervical intraepithelial neoplasia) and have an 80 percent higher chance of developing breast cancer after age 40. (nih.gov)
  • In 1971, the U.S. Food and Drug Administration issued a warning about the use of diethylstilbestrol during pregnancy after a relationship between exposure to this synthetic estrogen and the development of clear cell adenocarcinoma of the vagina and cervix was found in young women whose mothers had taken diethylstilbestrol while they were pregnant. (aafp.org)
  • However, physicians continued to prescribe DES to pregnant women until at least 1971, when a connection was established between in utero DES exposure and the development of clear cell adenocarcinoma of the vagina and cervix in the daughters of women who had taken DES during pregnancy. (aafp.org)
  • Clear Cell Adenocarcinoma (CCA) of the vagina/cervix is a rare cancer, even for DES Daughters. (desaction.org)
  • If you, or someone you know has been diagnosed with clear cell adenocarcinoma (CCA) of the vagina or cervix, you are asked to contact the University of Chicago Registry for Research on Hormonal Transplacental Carcinogenesis, the so-called DES Cancer Registry . (desaction.org)
  • Morphologic similarities between the clear cell carcinomas arising at diverse sites and the uncommon occurrence of clear cell adenocarcinoma within the colon make it difficult to differentiate this variant of colonic adenocarcinoma from a metastatic process. (thefreedictionary.com)
  • A 63-year-old Chinese woman initially presented to our facility with multifocal bilateral choroid metastatic lesions that were found to originate from a primary clear cell adenocarcinoma of the lung (T2bN2M1b, stage IV). (biomedcentral.com)
  • The pathology of the skin nodules revealed metastatic clear cell adenocarcinoma of unknown origin. (biomedcentral.com)
  • It has received U.S. FDA accelerated approval for the treatment of patients with metastatic Merkel cell carcinoma (MCC) and urothelial carcinoma. (clinicaltrials.gov)
  • This is a single institution open-label phase II trial of cabozantinib and nivolumab in patients with advanced or metastatic non-clear cell Renal Cell Carcinoma (nccRCC), who have not received prior PD-1/PD-L1 directed therapy. (clinicaltrials.gov)
  • A novel treatment approach prolonging survival in an uncommon metastatic primary bladder adenocarcinoma. (urotoday.com)
  • Intrahepatic bile duct cancer may be relatively indolent and difficult to clinically differentiate from metastatic adenocarcinoma deposits in the liver. (oncolink.org)
  • The main differential diagnosis in this case is to rule out an adenocarcinoma with focal clear cell features, fetal adenocarcinoma, metastatic renal cell carcinoma, in additional to clear cell ("sugar") tumor. (ucdavis.edu)
  • Ovarian involvement by metastatic colorectal adenocarcinoma: still a diagnostic challenge. (semanticscholar.org)
  • Ovarian involvement by metastatic colorectal adenocarcinoma, although not an uncommon occurrence, remains a diagnostic challenge. (semanticscholar.org)
  • When the ovarian cancer cells disseminate into the peritoneal cavity, metastatic nests may grow in the cul-de-sac, and in more advanced stages, the peritoneal surfaces of the upper abdomen become the next largest soil for cancer progression. (mdpi.com)
  • basal cell carcinoma the most common form of skin cancer, consisting of an epithelial tumor of the skin originating from neoplastic differentiation of basal cells , rarely metastatic but locally invasive and aggressive. (thefreedictionary.com)
  • Glassy cell carcinoma of the cervix Vaginal melanoma Smith, Emily K. (wikipedia.org)
  • Ahrens WA, Barron-Rodriguez LP, McKee M, Rivkees S, Reyes-Mugica M. Clear Cell Adenocarcinoma of the Cervix in a Child without In Utero Exposure to Diethylstilbestrol: A Case Report and Review of the Literature. (humpath.com)
  • Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis. (thefreedictionary.com)
  • Clear cell adenocarcinoma cervix: a diagnostic dilemma. (bvsalud.org)
  • A general term for the growth of abnormal cells on the surface of the cervix. (cdc.gov)
  • We report the case of a young girl who had hemihypertrophy and developed Wilms' tumor in both kidneys and clear-cell adenocarcinoma of the uterine cervix with no maternal history of stilbestrol ingestion during pregnancy. (uclouvain.be)
  • The link between hemihypertrophy and Wilms' tumor is well known, but their association with clear-cell carcinoma of the cervix has not been previously described. (uclouvain.be)
  • The purpose of this research was to compare the clinical behavior, pathology findings, and prognosis of surgically treated FIGO stage IB-IIB clear cell carcinomas of the cervix with those of squamous cell carcinomas and non-clear cell adenocarcinomas. (nih.gov)
  • Fifteen patients with clear cell adenocarcinomas of the cervix (8 FIGO stage IB, 7 FIGO stage IIB) were reviewed. (nih.gov)
  • The voided urine cytology revealed small clusters of rounded or papillary cells. (jpatholtm.org)
  • The voided urine cytology revealed moderate cellularity with small clusters of globular or papillary cells in the inflammatory background ( Fig. 2A ). (jpatholtm.org)
  • Adenocarcinoma of the lung may be classified according to WHO into mixed, acinar , papillary , bronchioloalveolar carcinoma , and subtypes. (wikidoc.org)
  • bronchioalveolar carcinoma ( bronchiolar carcinoma ) ( bronchioloalveolar carcinoma ) ( bronchoalveolar carcinoma ) a variant type of adenocarcinoma of the lung , with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. (thefreedictionary.com)
  • Data from ASTEC/CTG EN.5 trials randomizing patients with IC-IIA or IA-IIAG3 or serous papillary/clear cell (PLND done per institution) to +/- EBRT. (wikibooks.org)
  • Excluded papillary serous and clear cell. (wikibooks.org)
  • Other histologic subtypes include adenosquamous, clear cell, and papillary serous carcinomas. (medscape.com)
  • In gynecologic malignancies, ovarian Clear Cell Carcinoma (CCC) is one of the most commonhistologic subtypes, whereas HHM caused by endometrial CCC is very rare. (scirp.org)
  • To evaluate whether the immunohistochemical markers Hepatic Nuclear Factor 1b (HNF-1b), Wilms´tumor 1 (WT1), Estrogen Receptor α (ER), Glypican 3 (GLYP3) and Insulin-Like Growth Factor Binding Protein 1 (IGFBP-1), could differentiate the ovarian adenocarcinoma subtype clear cell adenocarcinoma (CCC) from serous and endometrioid adenocarcinoma more accurately than morphology alone, since clear cell adenocarcinoma in advanced stage has a worse prognosis than the other subtypes. (nordiqc2015.dk)
  • Only pure adenocarcinoma subtypes diagnosed on primary surgical specimens from the Department of Gynaecology and Obstetrics, Aalborg University Hospital were included. (nordiqc2015.dk)
  • In our hands, GLYP3 and IGFBP-1 were overlapping in all of the adenocarcinoma subtypes. (nordiqc2015.dk)
  • The goal of our study was to provide comprehensive data on the worldwide human papillomavirus (HPV) genotype distribution in patients with invasive cervical adenocarcinoma in correlation with histologic tumor subtypes, geographical location, patients' age, and duration of sample storage. (nature.com)
  • In addition, some of the histological subtypes of cervical adenocarcinomas have been previously reported as not related to HPV infection. (nature.com)
  • We evaluated epidemiologic trends and survival for bladder cancer histologic subtypes in California patients by comparing urothelial carcinoma of the bladder (UCB) and non-urothelial subtypes including squamous cell carcinoma (SCC), adenocarcinoma (ADC), and small-cell carcinoma (SmCC). (urotoday.com)
  • Clear cell adenocarcinoma with enteroblastic differentiation of the ascending colon," Journal of Clinical Oncology , vol. 29, no. 22, pp. e647-e649, 2011. (hindawi.com)
  • Several authors have reported frequent admixtures of clear cell ovarian carcinoma with serous, mucinous, and endometrioid tumors. (clinicaltrials.gov)
  • Dasatinib may shrink patients' tumors by blocking some of the enzymes needed for cell growth. (clinicaltrials.gov)
  • Three HPV genotypes, HPV 16, 18, and 45, dominated in all adenocarcinomas and together accounted for 94.1% of HPV-positive tumors. (nature.com)
  • Alpha-fetoprotein (AFP) is a useful tumor marker for ovarian germ cell tumors, particularly yolk sac tumor (YST). (biomedcentral.com)
  • Although immunohistochemical examination is not always needed in routine for the diagnosis of clear cell type EOC, to distinguish from other tumors, especially germ cell tumors, or to provide the better way to monitor therapeutic response or to evaluate the disease status, immunostaining, including GPC3, HNF-1 beta, CD30, cytokeratin 7 or 20, and AFP is taken into account. (biomedcentral.com)
  • Our findings suggest that microscopic oncocytic lesions may be precursors of hybrid oncocytic tumors, chromophobe renal cell carcinomas, and perhaps clear cell renal cell carcinomas in patients with BHD syndrome. (nih.gov)
  • Adenocarcinomas are highly heterogeneous tumors. (wikidoc.org)
  • not only epithelial tumors but also sex-cord stromal tumors and germ cell tumors frequently develop in this organ. (mdpi.com)
  • Germ cell tumors. (healthlinkbc.ca)
  • ER median H-score in serous and endometrioid adenocarcinomas were approximately 180, but close to zero in clear cell adenocarcinomas. (nordiqc2015.dk)
  • The median H-score concerning HNF-1b was 250 in clear cell adenocarcinomas, 90 in endometrioid adenocarcinomas and close to zero in serous adenocarcinomas. (nordiqc2015.dk)
  • We demonstrate that in discriminating CCC from serous and endometrioid adenocarcinomas, HNF-1b, WT1 and ER proved very useful. (nordiqc2015.dk)
  • Approximately eighty percent of endometrial carcinomas are endometrioid adenocarcinomas. (medscape.com)
  • The promoter methylation statuses of 40 genes in primary ovarian carcinomas including 47 clear- and 63 non-clear-cell type tissues, 6 OCCA cell lines, 29 benign ovarian endometriotic cysts, and 31 normal controls were analyzed by methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA). (springermedizin.de)
  • The same study revealed that in contrast to squamous cell carcinomas in which HPV was detected in 87% of cases, only 62% of adenocarcinomas were found to be HPV positive. (nature.com)
  • The control group consisted of 444 squamous cell carcinomas and 59 non-clear cell adenocarcinomas. (nih.gov)
  • Twelve of the fifteen clear cell carcinomas (80%) were endophytic and tended toward deep cervical infiltration. (nih.gov)
  • Clear cell carcinomas had a worse 5-year survival rate (67%) than squamous cell carcinomas (80%) and non-clear cell adenocarcinomas (77%) but this was not statistically significant (P = 0.6). (nih.gov)
  • The clinicopathologic findings and prognosis of surgically treated patients with stage IB-IIB clear cell carcinomas without exposure to diethylstilbestrol in utero are similar to those of patients with squamous cell carcinomas and non-clear cell adenocarcinomas. (nih.gov)
  • Twelve clear cell (conventional) renal carcinomas (12 of 130, 9%) were diagnosed in nine patients. (nih.gov)
  • The histopathology of tumor cells showed features with abundant clear cytoplasm and prominent cell boundaries. (dovepress.com)
  • Immunohistochemical staining showed diffuse weakly positive membrane staining of tumor cells with CA125. (sages.org)
  • carcinoma derived from glandular tissue or in which the tumor cells form recognizable glandular structures. (thefreedictionary.com)
  • Clear cell adenocarcinoma of the endometrium shows cells with clear cytoplasmand pleomorphic high-grade nuclei and the cytoplasm of tumor cells is strongly immunopositive for PTHrP (A, B ×400). (scirp.org)
  • Drugs used in chemotherapy, such as carboplatin, paclitaxel and gemcitabine hydrochloride work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (ucsd.edu)
  • Immunotherapy with monoclonal antibodies, such as bevacizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (ucsd.edu)
  • The necrotic debris and inflammatory cells were present within some clusters of tumor cells. (jpatholtm.org)
  • These tumor cells were enlarged and had abundant clear or granular cytoplasm with cytoplasmic vacuoles. (jpatholtm.org)
  • Avelumab is an anti-programmed death ligand-1 (PD-L1) fully human IgG1 antibody that inhibits PD1/PD-L1 interactions while leaving the PD1/PD-L2 pathway intact and enhances immune activation against tumor cells. (clinicaltrials.gov)
  • Unlike other approved anti-PD-L1/PD1 antibodies, avelumab induces lysis of tumor cells via antibody-dependent cell-mediated cytotoxicity (ADCC), indicating an additionalmechanism of action. (clinicaltrials.gov)
  • Tumor cells revealed strong immunoreactivity for glypican-3 (GPC3) and AFP and weak for hepatocyte nuclear factor-1 beta (HNF-1 beta), but negative for CD30, making the diagnosis of AFP-producing clear cell type EOC with fetal gut differentiation in focal areas, FIGO (International Federation of Gynecology and Obstetrics) IIIc. (biomedcentral.com)
  • The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. (genecards.org)
  • giant cell carcinoma a poorly differentiated, highly malignant, epithelial neoplasm containing many large multinucleated tumor cells, such as occurs in the lungs. (thefreedictionary.com)
  • 1 ] Although some thymoma histologic types are more likely to be invasive and clinically aggressive, treatment outcome and the likelihood of recurrence appear to correlate more closely with the invasive/metastasizing properties of the tumor cells. (healthlinkbc.ca)
  • 2. a histologic type of adenocarcinoma occurring chiefly in the male and female genitourinary tracts that is characterized by distinctive hobnail-cell growth of neoplastic cells in sheets, papillae, and coalescing glands. (thefreedictionary.com)
  • The hobnail cells and hyaline globules were also present as in a histologic section. (jpatholtm.org)
  • The histologic findings were compatible with clear cell adenocarcinoma. (jpatholtm.org)
  • The gross and histologic features of such metastases overlap those of primary ovarian epithelial neoplasms such as endometrioid or mucinous adenocarcinoma. (semanticscholar.org)
  • A thymic epithelial tumor that exhibits clear-cut cytologic atypia and histologic features no longer specific to the thymus is known as a thymic carcinoma (also known as type C thymoma). (healthlinkbc.ca)
  • clear cell adenocarcinoma a rare malignant tumor of the female genital tract, resembling a renal cell carcinoma and containing tubules or small cysts with some cells that are hobnail-shaped and others whose cytoplasm is clear, containing abundant glycogen and inconspicuous stroma. (thefreedictionary.com)
  • Micrograph of a small-cell carcinoma showing cells with nuclear moulding, minimal amount of cytoplasm and stippled chromatin. (wikipedia.org)
  • The neoplastic cells were cuboidal with clear to pale eosinophilic cytoplasm and abundant intracellular and extracellular eosinophilic hyaline globules. (elsevier.com)
  • The tumor is composed of polygonal, cuboidal to columnar cells with clear cytoplasm arranged in solid nests and tubule-cystic growth patterns. (biomedcentral.com)
  • The cells have clear to foamy eosinophilic cytoplasm and uniform round nuclei with vesicular chromatin and small round nucleoli. (ucdavis.edu)
  • In a letter to the editor of The New England Journal of Medicine , Dezheng Huo, MD , of the University of Chicago, Chicago, and colleagues described the long-term outcomes of women with vaginal and cervical clear cell adenocarcinoma associated with prenatal exposure to the synthetic nonsteroidal estrogen diethylstilbestrol (DES). (ascopost.com)
  • Our case is consistent with clear cell adenocarcinoma, probably related to diethylstilbestrol exposure in utero. (desdaughter.com)
  • Genital clear cell adenocarcinoma is a rare cancer in young women related to prenatal exposure to diethylstilbestrol (DES). (desdaughter.com)
  • From the Diethylstilbestrol Registry, an analysis of 57 cases of genital clear cell adenocarcinoma is presented from the state of California, the most populous state in the United States. (desdaughter.com)
  • A malignant glandular epithelial neoplasm characterized by the presence of clear and hobnail cells. (mycancergenome.org)
  • The present study was conducted using cell lines derived from ovarian clear cell adenocarcinoma in order to identify genes associated with the acquisition of malignant potential by this type of cancer. (elsevier.com)
  • The findings obtained using these cell lines derived from ovarian clear cell adenocarcinoma indicate that integrin alpha3 may associated with the acquisition of malignant potential by clear cell adenocarcinoma. (elsevier.com)
  • a malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues and to give rise to metastases. (thefreedictionary.com)
  • Hürthle cell carcinoma a malignant Hürthle cell tumor . (thefreedictionary.com)
  • Patients with clear cell adenocarcinoma had greater mortality risk across their life span. (ascopost.com)
  • The study found that DES-exposed patients with clear-cell adenocarcinoma had ' increased mortality across their life span . (desdaughter.com)
  • A total of 695 patients with clear-cell adenocarcinoma in the Registry for Research on Hormonal Transplacental Carcinogenesis were followed through 2014 (see the Methods section of the Supplementary Appendix , available with the full text of this letter at NEJM.org ). (desdaughter.com)
  • Since the epidemiologic curve was similar between the two groups, some of the patients with clear-cell adenocarcinoma for whom there was no documentation of DES exposure may have actually been exposed to DES in utero, and thus the true survival difference between women with DES exposure and those with idiopathic clear-cell adenocarcinoma would be larger without potential misclassification. (desdaughter.com)
  • Finally, a diagnosis of endometrioid adenocarcinoma was made. (sages.org)
  • The aim of the present report was to draw the attention of oncologists to the importance of prompt diagnosis of primary clear cell adenocarcinoma of the lung, which allows early initiation of treatment to maintain quality of life. (biomedcentral.com)
  • Major inclusion/exclusion criteria Eligible patients required histologically documented diagnosis of recurrent ovarian clear cell carcinoma, as evidenced by WT1 negativity. (bmj.com)
  • Cytologically, however, it is necessary to make a differential diagnosis from other adenocarcinoma or high-grade urothelial carcinoma. (jpatholtm.org)
  • The mean age at diagnosis of clear-cell adenocarcinoma was 22 years, and 80% of the patients received the diagnosis between the ages of 15 and 30 years. (desdaughter.com)
  • Our aim is to provide updated information on primary and secondary bladder adenocarcinomas, with focus on pathologic features, differential diagnosis, and clinical relevance. (urotoday.com)
  • The immunohistochemical stains being negative for CK5/6 and P63, as well as TTF1 and napsin A would make a diagnosis of either a squamous cell carcinoma or adenocarcinoma with clear cell features unlikely. (ucdavis.edu)
  • Each cell lysate is grouped by species, diagnosis, tissue& cell, tested applications and more. (prosci-inc.com)
  • Adeniran and Tamboli [10] in their review of clear cell carcinoma of the urinary bladder stated (see Figures 7(a), 7(b), 7(c), 7(d), 7(e), and 7(f) for various microscopic and immunohistochemical staining pictures of clear cell adenocarcinoma of bladder and some differential diagnoses) the following. (thefreedictionary.com)
  • The upper part of the lumen of the urinary bladder was clear. (jpatholtm.org)
  • On the surgical field, the patient had a lobulated tumor mass of about 3 cm in diameter in the urethra and had the clear urinary bladder. (jpatholtm.org)
  • Bladder exstrophy with adenocarcinoma in an adult patient: a case report]. (urotoday.com)
  • Primary bladder adenocarcinoma (PBA) is an epithelial malignancy with pure glandular differentiation, without evidence of typical urothelial (transitional cell) carcinoma. (urotoday.com)
  • Adenocarcinoma of the urinary bladder. (urotoday.com)
  • Adenocarcinoma is an uncommon malignancy in the urinary bladder which may arise primarily in the bladder as well as secondarily from a number of other organs. (urotoday.com)
  • Asparagine limitation in melanoma and pancreatic cancer cells activates receptor tyrosine kinase-MAPK signalling as part of a feedforward mechanism involving mammalian target of rapamycin complex 1 (mTORC1)-dependent increase in MAPK-interacting kinase 1 (MNK1) and eukaryotic translation initiation factor 4E (eIF4E), resulting in enhanced translation of activating transcription factor 4 ( ATF4 ) mRNA. (nature.com)
  • N. Bakshi, S. Sharma, V. Kaushal, and K. Mardi, "Clear cell adenocarcinoma of the colon is a unique morphologic variant of intestinal carcinoma: a rare case report," Clinical Cancer Investigation Journal , vol. 1, pp. 173-175, 2012. (hindawi.com)
  • There are 16 clinical trials for ovarian clear cell adenocarcinoma, of which 14 are open and 2 are completed or closed. (mycancergenome.org)
  • BRCA1, BRCA2, and ARID1A are the most frequent gene inclusion criteria for ovarian clear cell adenocarcinoma clinical trials [ 3 ]. (mycancergenome.org)
  • Paclitaxel, carboplatin, and pembrolizumab are the most common interventions in ovarian clear cell adenocarcinoma clinical trials. (mycancergenome.org)
  • ARID1A is an inclusion eligibility criterion in 2 clinical trials for ovarian clear cell adenocarcinoma, of which 2 are open and 0 are closed. (mycancergenome.org)
  • The clinical and pathological features of our patient's case were compatible with a clear cell adenocarcinoma of the lung (T2bN2M1b, stage IV, according to the American Joint Committee on Cancer (AJCC) cancer staging guide, seventh edition). (biomedcentral.com)
  • I. To assess the clinical activity of dasatinib in patients with recurrent or persistent ovarian, fallopian tube, primary peritoneal, and endometrial clear cell carcinoma using objective tumor response (complete and partial): in patients without loss of BRG-associated factor 250a (BAF250a) expression and in patients with loss of BAF250a expression. (clinicaltrials.gov)
  • This study aimed to compare the clinical characteristics and outcomes of the cases with pure ovarian clear cell adenocarcinoma (OCCC), mixed type (clear plus serous or clear plus endometrioid or serous plus clear plus endometrioid) ovarian adenocarcinoma (MOC) and high-grade serous ovarian adenocarcinoma (HGSOC). (cu.edu.tr)
  • To provide a better understanding of clinical and molecular characteristics of the AFP-producing clear cell type EOC, we conducted a systematic literature review. (biomedcentral.com)
  • The introduction of paclitaxel markedly changed the postoperative management of ovarian cancer patients, but the results and value of these newer efforts and therapies applied to clear cell carcinoma are as yet undetermined. (clinicaltrials.gov)
  • Urethral cancer is a rare malignancy with urothelial subtype being the most common followed by adenocarcinoma. (urotoday.com)
  • 2 Three case reports are documented in the literature of clear cell ovarian cancer presenting with hypercalcemia. (thepermanentejournal.org)
  • Clear cell adenocarcinoma (CCA) is a rare form of vaginal and cervical cancer in which the inside of the tumorous cells appear clear when viewed through a microscope. (diseasesandconditions.net)
  • Generally, early-stage clear cell cancer is successfully treated with radical pelvic surgery. (desdaughter.com)
  • Trial design The MOCCA study is a multicenter, open-label, randomized phase II trial in patients with recurrent ovarian clear cell carcinoma, which recruited from eight sites across Gynecologic Cancer Group Singapore (GCGS), Korean Gynecologic-Oncology Group (KGOG), and Australia New Zealand Gynecological Oncology Group (ANZGOG). (bmj.com)
  • A cancer that begins in cells that line certain internal organs and that have glandular (secretory) properties. (cdc.gov)
  • Cancer cells can invade nearby tissues and can spread through the bloodstream and lymphatic system to other parts of the body. (cdc.gov)
  • CIS interprets and explains research findings in a clear and understandable manner and provides personalized responses to specific questions about cancer. (cdc.gov)
  • Cancer that involves only the cells in which it began and has not spread to nearby tissues. (cdc.gov)
  • Here we demonstrate a role of translational reprogramming in the survival of asparagine-restricted cancer cells. (nature.com)
  • Indeed, many common oncogenic signaling pathways have been implicated in the emergence of specific metabolic features in cancer cells that have been associated with both survival and sustained abnormal proliferation rate ( 2 ⇓ ⇓ - 5 ). (pnas.org)
  • Only recently a systemic study using transcriptional regulation has attempted to rule out the possibility that other metabolic processes in the network may achieve equal importance in cancer cells ( 6 ), and the idea that all cancer cells display a unique metabolic phenotype has spurred disputes that mainly highlighted a lack of comprehensive evidence ( 7 ). (pnas.org)
  • Taken together, we contend that only a systems perspective may help to elucidate the extent to which different cancer cells coordinate their metabolic activity. (pnas.org)
  • Clear-cell renal cell carcinoma (ccRCC) is a kind of kidney cancer. (clinicaltrials.gov)
  • The drug IL-15 stimulates certain kinds of white blood cells that have the potential to attack the cancer. (clinicaltrials.gov)
  • The immunologic effects of recombinant human Interleukin-15 (rhIL-15), a stimulatory cytokine that promotes the differentiation and activation of NK cells, monocytes and longterm CD8+ memory T-cells, has been assessed in several Phase 1 trials in cancer patients. (clinicaltrials.gov)
  • Among various types of surface epithelial ovarian carcinoma, clear cell adenocarcinoma often has a particularly poor prognosis even when diagnosed in stage I. It is resistant to existing anticancer drugs and appears to have different biological properties to other histological types of ovarian cancer. (elsevier.com)
  • Primers were established using these base sequences and the level of expression in each cancer cell line was determined by real-time PCR. (elsevier.com)
  • There has been scarce information about clear cell adenocarcinoma of the urethra (CCAU), an extremely rare type of cancer. (jocmr.org)
  • Clear cell adenocarcinoma of the urethra (CCAU), an extremely rare type of cancer, has been reported to occur more commonly in the female than in male [ 1 ]. (jocmr.org)
  • This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN. (genecards.org)
  • E, TDB mediated killing of ovarian cancer cell lines measured by flow cytometry, EC 50 are indicated. (aacrjournals.org)
  • The majority of ovarian cancers grow as cystic masses, and cancer cells easily spread into the pelvic cavity once the cysts rupture or leak. (mdpi.com)
  • Womb cancer develops when the cells in your womb start functioning abnormally. (bmihealthcare.co.uk)
  • This means that the cancer is in the glandular tissue cells, and that is started in a surface layer of the cells. (bmihealthcare.co.uk)
  • The 'prognosis' of Adenocarcinoma, Clear Cell usually refers to the likely outcome of Adenocarcinoma, Clear Cell. (rightdiagnosis.com)
  • Clear cell variety of adenocarcinoma is a rarer entity which usually has a better prognosis than other variants. (urotoday.com)
  • The prognosis of clear cell adenocarcinoma is unknown due to its rarity. (ucdavis.edu)
  • Liu, KW, Lin, VCH & Chang, IW 2013, ' Clear cell adenocarcinoma of the renal pelvis: An extremely rare neoplasm of the upper urinary tract ', Polish Journal of Pathology , vol. 64, no. 4, pp. 308-311. (elsevier.com)
  • Loss of integrin alpha3 expression associated with acquisition of invasive potential by ovarian clear cell adenocarcinoma cells. (elsevier.com)
  • Two cell lines derived from ovarian clear cell adenocarcinoma (RMG-I and RMG-V), with different levels of invasive potential in an invasion assay, were used. (elsevier.com)
  • Fingerprint Dive into the research topics of 'Loss of integrin alpha3 expression associated with acquisition of invasive potential by ovarian clear cell adenocarcinoma cells. (elsevier.com)
  • Adenocarcinoma of the lung may be classified according to IASLC/ATS/ERS into pre-invasive lesions, atypical adenomatous hyperplasia, adenocarcinoma in situ, minimally invasive adenocarcinoma, invasive adenocarcinoma, and variants of invasive adenocarcinoma. (wikidoc.org)
  • Clear cell carcinoma comprises 5-10% of surface epithelial ovarian cancers, and about 30-40% of the patients with clear cell carcinoma are diagnosed in the advanced stage. (clinicaltrials.gov)
  • since clear cell cancers can develop, not infrequently, in foci of endometriosis, our patient's pathology specimen was carefully inspected for endometriosis and none was found. (desdaughter.com)
  • Clear-cell renal cell carcinoma (ccRCC) is among the 10 most frequent diagnostic cancers in the United States with more than an estimated 62,000 new cases in 2016. (clinicaltrials.gov)
  • In this review, I discuss the roles of stromal cells and inflammatory factors in the carcinogenesis and progression of ovarian cancers. (mdpi.com)
  • Around 95 out of 100 endometrial cancers are adenocarcinomas. (bmihealthcare.co.uk)
  • Endometrial adenocarcinoma is the most common gynecologic malignancy in the United States. (medscape.com)
  • This differential effect of DES according to time suggests that clear-cell adenocarcinoma associated with DES exposure and idiopathic clear-cell adenocarcinoma may have different tumor biologic features. (desdaughter.com)
  • Idiopathic clear-cell adenocarcinoma may be more likely to progress quickly or recur earlier, whereas clear-cell adenocarcinoma associated with DES exposure may be more likely to recur later. (desdaughter.com)
  • The association between in utero DES exposure and vaginal clear cell adenocarcinoma has been well documented. (aafp.org)
  • cholangiocellular carcinoma a rare type of hepatocellular carcinoma arising from the cholangioles , consisting of two layers of cells surrounding a minute lumen. (thefreedictionary.com)
  • hepatocellular carcinoma primary carcinoma of the liver cells with hepatomegaly, jaundice, hemoperitoneum, and other symptoms of the presence of an abdominal mass. (thefreedictionary.com)
  • adenocarcinoma of the lung , large cell carcinoma , small cell carcinoma , and squamous cell carcinoma . (thefreedictionary.com)
  • The investigators studied the response to chemotherapy and survival for either paclitaxel-platinum based chemotherapy or conventional platinum-based chemotherapy among all stages clear cell ovarian carcinoma. (clinicaltrials.gov)
  • Previous research suggests a potential benefit of paclitaxel plus carboplatin regimens for stage I clear cell carcinoma. (clinicaltrials.gov)
  • However, few papers specifically addressed the efficacy of paclitaxel-platinum-based chemotherapy for advanced clear cell carcinoma because clear cell carcinoma occurs only rarely in Western countries. (clinicaltrials.gov)
  • The HIN-1 gene was over-expressed in ES2 cells, a significant reduction in cell growth and induction of apoptosis, and increasing paclitaxel sensitivity by reducing phosphorylation of Akt were observed. (springermedizin.de)
  • Ho CM, Chien TY, Shih BY, Huang SH: Evaluation of complete surgical staging with pelvic and para-aortic lymphadenectomy and paclitaxel plus carboplatin chemotherapy for improvement of survival in stage I ovarian clear cell carcinoma. (springermedizin.de)
  • The therapeutic effect of a combination of paclitaxel (PTX) and platinum (PLT) in ovarian clear cell adenocarcinoma (CC) patients with measurable disease has yet to be elucidated. (elsevier.com)
  • Does lung adenocarcinoma subtype predict patient survival? (wikidoc.org)
  • Endometrial curetting revealed poorly-differentiated adenocarcinoma of the endometrium, suggesting clear cell adenocarcinoma. (scirp.org)
  • The detailed evaluation revealed clear cell adenocarcinoma of the urethra as the primary with lymph node metastasis. (urotoday.com)
  • However, few papers addressed the difference in response to chemotherapy and survival between patients with pure and mixed-type advanced clear cell carcinoma. (clinicaltrials.gov)
  • Here, we present a case of primary clear cell adenocarcinoma of the lung with multifocal bilateral CM as the initial presentation in an otherwise healthy woman who had a significant and durable response to systemic chemotherapy using cisplatin and pemetrexed. (biomedcentral.com)
  • Primary objective To evaluate the efficacy of durvalumab (MEDI-4736) compared with standard chemotherapy in patients with recurrent ovarian clear cell carcinoma. (bmj.com)
  • Study hypothesis Patients with recurrent ovarian clear cell carcinoma treated with durvalumab will have improved progression-free survival compared with those treated with chemotherapy of physician's choice. (bmj.com)
  • Due to rarity, the appropriate chemotherapy regimen and the biological behavior of AFP-producing clear cell type EOC are still unclear. (biomedcentral.com)
  • alveolar adenocarcinoma ( bronchioalveolar adenocarcinoma ) ( bronchiolar adenocarcinoma ) ( bronchioloalveolar adenocarcinoma ) ( bronchoalveolar adenocarcinoma ) bronchioloalveolar carcinoma . (thefreedictionary.com)
  • Called also alveolar carcinoma or adenocarcinoma and bronchiolar , bronchioloalveolar , or bronchoalveolar adenocarcinoma . (thefreedictionary.com)
  • adenocarcinoma of the lung a type of bronchogenic carcinoma made up of cuboidal or columnar cells in a discrete mass, usually at the periphery of the lungs. (thefreedictionary.com)
  • large cell carcinoma a type of bronchogenic carcinoma of undifferentiated (anaplastic) cells of large size, a variety of squamous cell carcinoma that has undergone further dedifferentiation. (thefreedictionary.com)
  • Recommendations for gynecologic examinations include vaginal and cervical digital palpation, which may provide the only evidence of clear cell adenocarcinoma. (aafp.org)
  • Such modifications are critical to early developmental cellular differentiation pathways and, for example, explain why, with the same DNA, epidermal cells are so different from neurons. (aappublications.org)
  • We report a 55-year-old postmenopausal woman with AFP-producing clear cell type EOC with fetal gut differentiation, FIGO (International Federation of Gynecology and Obstetrics) IIIC, and conducted a systematic literature review for published cases of AFP-producing clear cell type EOC. (biomedcentral.com)
  • Carbohydrate chains on cell membranes contributes to the mutal recognition of various cells and cell differentiation, and the structure of carbohydrate chains changes with oncogenesis. (nii.ac.jp)
  • Clear cell adenocarcinoma (CCA) in the urinary tract is a rare neoplasmmorphologically identical to the Müllerian counterpart. (elsevier.com)
  • Clear cell adenocarcinoma is extremely rare in the upper urinary tract. (elsevier.com)
  • We have reported a case of clear cell adenocarcinoma of the endometrium with hypercalcemia and demonstrated the expression of PTHrP in the tumor tissue at cellular level by immunohistochemistry. (scirp.org)
  • Adenocarcinoma of the endometrium. (medscape.com)
  • Immunohistochemical analysis of neoplastic cells showed reactions to antibodies against cytokeratin-7 and showed no reactions to antibodies against hepatocyte nuclear factor-1β, carbonic anhydrase 9, synaptophysin, and chromogranin A. The patient was subsequently diagnosed with a primary clear cell carcinoma of the pancreas. (dovepress.com)
  • The cells are spindle-shaped, display neoplastic and pleomorphic features, and grow in a jigsaw puzzle-like arrangement while forming monolayers without contact inhibition. (elsevier.com)