Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Adenocarcinoma, Clear Cell: An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)Sarcoma, Clear Cell: A sarcoma of young, often female, adults of the lower extremities and acral regions, intimately bound to tendons as circumscribed but unencapsulated melanin-bearing tumors of neuroectodermal origin. An ultrastructural finding simulates flattened and curved barrel staves, corresponding to the internal structures of premelanosomes. There is a 45-60% mortality in clear cell sarcoma. (Segen, Dictionary of Modern Medicine, 1992)Kidney Neoplasms: Tumors or cancers of the KIDNEY.Carcinoma, Renal Cell: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Von Hippel-Lindau Tumor Suppressor Protein: A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.Lung Neoplasms: Tumors or cancer of the LUNG.Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Barrett Esophagus: A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.Adenocarcinoma, Bronchiolo-Alveolar: A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)Stomach Neoplasms: Tumors or cancer of the STOMACH.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Hyalin: A clear, homogenous, structureless, eosinophilic substance occurring in pathological degeneration of tissues.Periodic Acid-Schiff Reaction: A histochemical technique for staining carbohydrates. It is based on PERIODIC ACID oxidation of a substance containing adjacent hydroxyl groups. The resulting aldehydes react with Schiff reagent to form a colored product.Cardia: That part of the STOMACH close to the opening from ESOPHAGUS into the stomach (cardiac orifice), the ESOPHAGOGASTRIC JUNCTION. The cardia is so named because of its closeness to the HEART. Cardia is characterized by the lack of acid-forming cells (GASTRIC PARIETAL CELLS).Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Cell Line, Tumor: A cell line derived from cultured tumor cells.Tissue Array Analysis: The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.Cystadenocarcinoma, Serous: A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)Colonic Neoplasms: Tumors or cancer of the COLON.Adenoma, Oxyphilic: A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.Keratin-7: A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Esophagogastric Junction: The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Chromosomes, Human, Pair 3: A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.von Hippel-Lindau Disease: An autosomal dominant disorder caused by mutations in a tumor suppressor gene. This syndrome is characterized by abnormal growth of small blood vessels leading to a host of neoplasms. They include HEMANGIOBLASTOMA in the RETINA; CEREBELLUM; and SPINAL CORD; PHEOCHROMOCYTOMA; pancreatic tumors; and renal cell carcinoma (see CARCINOMA, RENAL CELL). Common clinical signs include HYPERTENSION and neurological dysfunctions.Adenoma, Sweat Gland: A benign neoplasm derived from epithelial cells of sweat glands. (Stedman, 25th ed)Neoplasm Grading: Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Nephrectomy: Excision of kidney.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Sweat Gland NeoplasmsCarcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.DNA, Neoplasm: DNA present in neoplastic tissue.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Carcinoma, Acinar Cell: A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Tumor Suppressor Proteins: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Loss of Heterozygosity: The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Vaginal Neoplasms: Tumors or cancer of the VAGINA.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Uterine Neoplasms: Tumors or cancer of the UTERUS.Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Neoplasms, Glandular and Epithelial: Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.Carcinoma, Signet Ring Cell: A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.Adenoma: A benign epithelial tumor with a glandular organization.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Cecal Neoplasms: Tumors or cancer of the CECUM.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Mammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Metaplasia: A condition in which there is a change of one adult cell type to another similar adult cell type.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Myoepithelioma: A usually benign tumor made up predominantly of myoepithelial cells.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Genes, Tumor Suppressor: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.Cystadenocarcinoma, Mucinous: A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Carbonic Anhydrases: A family of zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide. They play an important role in the transport of CARBON DIOXIDE from the tissues to the LUNG. EC 4.2.1.1.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Rectal Neoplasms: Tumors or cancer of the RECTUM.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Ampulla of Vater: A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.Genes, ras: Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Common Bile Duct Neoplasms: Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.Odontogenic Tumors: Neoplasms produced from tooth-forming tissues.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Keratin-20: A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Ileal Neoplasms: Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).Neoplasms, Adnexal and Skin Appendage: Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Receptor, Epidermal Growth Factor: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.Pancreaticoduodenectomy: The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.RNA, Neoplasm: RNA present in neoplastic tissue.DNA Methylation: Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Cystadenofibroma: Benign or borderline malignant neoplasm of the ovary and surrounding tissues. It is characterized by tumor(s) with cystic glands which are lined by cuboidal EPITHELIAL CELLS with clear cytoplasm, resembling ENDOMETRIUM cells. The glands are separated by fibroblastic STROMAL CELLS.Jejunal Neoplasms: Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).Hypoxia-Inducible Factor 1, alpha Subunit: Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.Acanthoma: A neoplasm composed of squamous or epidermal cells.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Carcinoma, Adenosquamous: A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Vacuolar Proton-Translocating ATPases: Proton-translocating ATPases that are involved in acidification of a variety of intracellular compartments.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Mucin-1: Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.Cystadenocarcinoma: A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)Ligases: A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.Esophagus: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Fluorescent Antibody Technique, Direct: A form of fluorescent antibody technique utilizing a fluorochrome conjugated to an antibody, which is added directly to a tissue or cell suspension for the detection of a specific antigen. (Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Transplantation, Heterologous: Transplantation between animals of different species.Mixed Tumor, Mullerian: A tumor, basically a carcinoma with a single sarcoma such as leiomyosarcoma or angiosarcoma or multiple sarcomas of uterine origin. The role of estrogen has been postulated as a possible etiological factor in this tumor. (Holland et al., Cancer Medicine, 3d ed, p1703)Soft Tissue Neoplasms: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.Oncogene Proteins, Fusion: The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.Hepatocyte Nuclear Factor 1-beta: A hepatocyte nuclear factor that is closely related to HEPATOCYTE NUCLEAR FACTOR 1-ALPHA but is only weakly expressed in the LIVER. Mutations in hepatocyte nuclear factor 1-beta are associated with renal CYSTS and MATURITY-ONSET DIABETES MELLITUS type 5.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Ki-67 Antigen: A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Gastrectomy: Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)Epididymis: The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.Ependymoma: Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Ubiquitin-Protein Ligases: A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.Paranasal Sinus Neoplasms: Tumors or cancer of the PARANASAL SINUSES.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Carcinoma in Situ: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.Cystadenoma, Mucinous: A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Hysterectomy: Excision of the uterus.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Radioimmunoprecipitation Assay: Sensitive assay using radiolabeled ANTIGENS to detect specific ANTIBODIES in SERUM. The antigens are allowed to react with the serum and then precipitated using a special reagent such as PROTEIN A sepharose beads. The bound radiolabeled immunoprecipitate is then commonly analyzed by gel electrophoresis.Pancreatectomy: Surgical removal of the pancreas. (Dorland, 28th ed)Molecular Targeted Therapy: Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Adenofibroma: A benign neoplasm composed of glandular and fibrous tissues, with a relatively large proportion of glands. (Stedman, 25th ed)Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Mucins: High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.Gastrointestinal Neoplasms: Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.Perivascular Epithelioid Cell Neoplasms: A family of mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. These cells do not have a normal anatomic homolog. (From Fletcher CDM, et. al., World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone, 2002).Biopsy, Needle: Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.Endometriosis: A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Appendiceal Neoplasms: Tumors or cancer of the APPENDIX.Gene Amplification: A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.Palatal Neoplasms: Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.Urethral Neoplasms: Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Primary urethral carcinomas are rare and typically of squamous cells. Urethral carcinoma is the only urological malignancy that is more common in females than in males.Pancreatic Ducts: Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.Nephroma, Mesoblastic: A solid, unencapsulated tumor of the KIDNEY composed of spindle mesenchymal cells that resemble FIBROBLASTS or muscle cells. The homogeneous mass typically extends into the renal parenchyma and replaces most of the kidney. In most cases, mesoblastic nephroma is benign and occurs in the fetus or newborn, and rarely in the older child or the adult.Pyrroles: Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Histocytochemistry: Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.Gallbladder Neoplasms: Tumors or cancer of the gallbladder.Hemangioblastoma: A benign tumor of the nervous system that may occur sporadically or in association with VON HIPPEL-LINDAU DISEASE. It accounts for approximately 2% of intracranial tumors, arising most frequently in the cerebellar hemispheres and vermis. Histologically, the tumors are composed of multiple capillary and sinusoidal channels lined with endothelial cells and clusters of lipid-laden pseudoxanthoma cells. Usually solitary, these tumors can be multiple and may also occur in the brain stem, spinal cord, retina, and supratentorial compartment. Cerebellar hemangioblastomas usually present in the third decade with INTRACRANIAL HYPERTENSION, and ataxia. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2071-2)DeoxycytidineXenograft Model Antitumor Assays: In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.Cystadenocarcinoma, Papillary: An adenocarcinoma in which the tumor elements are arranged as finger-like processes or as a solid spherical nodule projecting from an epithelial surface.Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Diethylstilbestrol: A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Sigmoid Neoplasms: Tumors or cancer of the SIGMOID COLON.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Esophagectomy: Excision of part (partial) or all (total) of the esophagus. (Dorland, 28th ed)Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Endometrial Hyperplasia: Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissue. There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant.Microdissection: The performance of dissections with the aid of a microscope.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Liver Neoplasms: Tumors or cancer of the LIVER.Gene Silencing: Interruption or suppression of the expression of a gene at transcriptional or translational levels.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Epithelioid Cells: Characteristic cells of granulomatous hypersensitivity. They appear as large, flattened cells with increased endoplasmic reticulum. They are believed to be activated macrophages that have differentiated as a result of prolonged antigenic stimulation. Further differentiation or fusion of epithelioid cells is thought to produce multinucleated giant cells (GIANT CELLS).Microsatellite Repeats: A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Prostatic Intraepithelial Neoplasia: A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Real-Time Polymerase Chain Reaction: Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.ras Proteins: Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Melanoma-Specific Antigens: Cellular antigens that are specific for MELANOMA cells.Carcinoma, Large Cell: A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.

Increased expression of the RIalpha subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer. (1/413)

The primary element in the cAMP signal transduction pathway is the cAMP-dependent protein kinase (PKA). Expression of the RIalpha subunit of type I PKA is elevated in a variety of human tumours and cancer cell lines. The purpose of this study was to assess the prognostic importance of RIalpha expression in patients with ovarian cancer. We have evaluated the expression of RIalpha in a panel of human ovarian tumours (n = 40) and five human ovarian cancer cell lines using quantitative reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis. The human ovarian cell lines OAW42 and OTN14 express high endogenous levels of RIalpha mRNA and protein (at significantly higher mRNA levels than high tissue expressors, P < 0.05). The ovarian cell line A2780 expresses low endogenous levels of RIalpha mRNA and protein (also at higher mRNA levels than low tissue expressors, P < 0.05). Quantitative RT-PCR revealed no significant difference in RIalpha mRNA expression between different ovarian histological subtypes in this study. No associations were found between RIalpha mRNA expression and differentiation state. RIalpha mRNA expression was significantly associated with tumour stage (P = 0.0036), and this remained significant in univariate analysis (P = 0.0002). A trend emerged between RIalpha mRNA expression levels and overall survival in univariate analysis (P = 0.051), however, by multivariate analysis, stage remained the major determinant of overall survival (P = 0.0001). This study indicates that in ovarian epithelial tumours high RIalpha mRNA expression is associated with advanced stage disease. RIalpha expression may be of predictive value in ovarian cancer and may be associated with dysfunctional signalling pathways in this cancer type.  (+info)

Loss of heterozygosity at 3p14.2 in clear cell renal cell carcinoma is an early event and is highly localized to the FHIT gene locus. (2/413)

The VHL tumor suppressor gene (TSG) at 3p25-26 is strongly implicated in the pathogenesis of clear cell renal cell carcinoma (cRCC). In addition, 3p14.2 and 3p21 are suspected of harboring additional TSGs in cRCC, with FHIT being a candidate TSG at 3p14.2. We examined 87 microdissected, histologically well-defined cRCCs classified according to tumor-node-metastasis (TNM) stage (stage 1, 23 cases; stage 2, 14 cases; stage 3, 24 cases; stage 4, 26 cases) and Fuhrman grade (grade 1, 24 cases; grade 2, 19 cases; grade 3, 19 cases; grade 4, 8 cases; sarcomatoid cRCC, 17 cases) for loss of heterozygosity (LOH) at 3p14.2 and 3p25-26 using a series of precisely mapped microsatellite probes. We found that LOH at 3p14.2 exceeded LOH at 3p25-26 in frequency (69% versus 48.3%; P < 0.03) and was highly localized to markers within the FHIT gene locus (D3S1300 and D3S4260), with the majority of chromosomal breakpoints also mapping to this region. In addition, 3p14.2 LOH (P < 0.03), but not 3p25-26 LOH (P = nonsignificant), was associated with lower tumor grades (grades 1-3). These findings suggest that 3p14.2 genomic deletions may be among the earliest events in cRCC pathogenesis, preceding genomic deletions at the VHL locus. FHIT, or an as yet undiscovered TSG mapping to the D3S4103-D3S4260 interval, could be the molecular target of the 3p14.2 deletions.  (+info)

Prognostic value of nuclear morphometry in patients with TNM stage T1 ovarian clear cell adenocarcinoma. (3/413)

In 40 patients with TNM stage T1 ovarian clear cell adenocarcinoma, we used nuclear morphometry to study the relations among morphometric variables, clinical prognostic factors and outcome. The presence of one or more giant nuclear cells was positively associated with death (OR = 10.6, P = 0.02) and tended to be associated with disease recurrence (OR = 5.1, P = 0.07). Nuclear irregularity (expressed in terms of the nuclear roundness factor) was positively associated with both death (OR = 8.6, P = 0.02) and disease recurrence (OR = 8.2, P = 0.02). A combination of giant nuclear cell presence or nuclear irregularity proved to be a useful prognostic indicator, with a sensitivity and specificity of 83% and 71% in the prediction of death, and 75% and 71% in the prediction of disease recurrence. Patients' age and substage were of no prognostic value. We conclude that the nuclear morphometric characteristics, especially the presence of giant nuclear cells and nuclear irregularity, may be useful in predicting outcome in patients with early stage ovarian clear cell adenocarcinoma.  (+info)

Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma. (4/413)

The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in patients with VHL disease and in the majority of patients with sporadic clear cell renal carcinoma (RCC). Overexpression of transforming growth factor (TGF) beta1 has been observed in patients with several cancers, including RCCs, with serum and urine levels correlating inversely with prognosis. We have demonstrated that the VHL tumor suppressor gene product represses TGF-beta1 mRNA and protein levels (approximately 3-4-fold) in 786-O RCC cells by decreasing the TGF-beta1 mRNA half-life. Exogenously added TGF-beta1 did not suppress the growth of 786-O cells in vitro, nor did the addition of neutralizing antibody (Ab) against TGF-beta have any effect. Indeed, 786-O cells were found to express no TGF-beta type II receptor protein, thus allowing them to escape from the negative growth control of TGF-beta1. In contrast to the in vitro data, neutralizing Ab to TGF-beta inhibited tumorigenesis and, in some cases, regressed established 786-O tumors in athymic mice. Immunohistochemistry for von Willebrand's factor revealed a 3-4-fold lower tumor microvessel count in the mice treated with TGF-beta Ab compared to controls, suggesting that the Ab was inhibiting angiogenesis. Our findings indicate that TGF-beta1 is a novel target for the VHL tumor suppressor and that antagonizing its paracrine action may provide novel avenues for treatment of RCCs as well as other tumors that secrete TGF-beta1.  (+info)

Clear cell carcinoma arising in a Cesarean section scar endometriosis: a case report. (5/413)

Endometriosis of a surgical scar is rare and occurs mainly when a hysterectomy or Cesarean section was performed. We describe a 54-year-old woman with a large suprapubic mass as a definite case of a endomerioid carcinoma developing within the scar endometriosis following Cesarean section. Scar endometriosis, as well as endometriosis at other sites, can turn malignant. Endometrioid carcinoma is the most common histological pattern of malignant tumor arising in endometriosis. But clear cell carcinoma is very unusual. A case of primary clear cell carcinoma in endometriosis of a Cesarean section scar is described. To the best of our knowledge, this is the first documented case of endomerioid carcinoma developing within the scar endometriosis in Korea.  (+info)

Overexpression of H-Ryk in mouse fibroblasts confers transforming ability in vitro and in vivo: correlation with up-regulation in epithelial ovarian cancer. (6/413)

Abnormalities in the function of receptor tyrosine kinases (RTKs) have been demonstrated to be important in the pathogenesis of cancer. H-Ryk, a new member of the RTK family, is an unusual RTK in that it is catalytically inactive because of amino acid substitutions of conserved residues in the catalytic domain. We show by immunohistochemistry that it is expressed in the epithelium, stroma, and blood vessels of normal tissues. Evaluation of a panel of 33 primary ovarian tumors (2 benign, 8 borderline, and 23 malignant) was performed. H-Ryk was overexpressed in borderline and malignant ovarian tumors. In serous and clear cell subtypes, there was increased expression in the epithelium, stroma, and blood vessels. Consistent with this observation, overexpression of H-Ryk in the mouse fibroblast cell line NIH3T3 induces anchorage-independent growth and tumorigenicity in nude mice. This implies that overexpression of the receptor can be transforming and may therefore be significant in the pathogenesis of ovarian cancer.  (+info)

Determination of telomerase activity for differential analysis of multifocal renal cell carcinomas. (7/413)

Secondary tumors are found in approximately 12 to 22% of all renal cell carcinoma, and their origin is currently unknown. To determine their potential for malignancy, we examined the telomerase activity of primary tumors and secondary lesions, and found that 86% of the lesions had an identical telomerase status as the related primary tumors, and thus probably share their malignancy potential.  (+info)

Hormone replacement therapy and risk of epithelial ovarian cancer. (8/413)

It has been suggested that oestrogen replacement therapy is associated with risk of epithelial ovarian cancer of the endometrioid type. Using data from an Australian population-based case-control study, the relation between unopposed oestrogen replacement therapy and epithelial ovarian cancer, both overall and according to histological type, was examined. A total of 793 eligible incident cases of epithelial ovarian cancer diagnosed from 1990 to 1993 among women living in Queensland, New South Wales and Victoria were identified. These were compared with 855 eligible female controls selected at random from the electoral roll, stratified by age and geographic region. Trained interviewers administered standard questionnaires to obtain detailed reproductive and contraceptive histories, as well as details about hormone replacement therapy and pelvic operations. No clear associations were observed between use of hormone replacement therapy overall and risk of ovarian cancer. Unopposed oestrogen replacement therapy was, however, associated with a significant increase in risk of endometrioid or clear cell epithelial ovarian tumours (odds ratio (OR) 2.56; 95% confidence interval (CI) 1.32-4.94). In addition, the risk associated with oestrogen replacement therapy was much larger in women with an intact genital tract (OR 3.00; 95% CI 1.54-5.85) than in those with a history of either hysterectomy or tubal ligation. Post-menopausal oestrogen replacement therapy may, therefore, be a risk factor associated with endometrioid and clear cell tumours in particular. Additionally, the risk may be increased predominantly in women with an intact genital tract. These associations could reflect a possible role of endometriosis in the development of endometrioid or clear cell ovarian tumours.  (+info)

Low expression of S100P is associated with poor prognosis in patients with clear cell adenocarcinoma of the ovaryLow expression of S100P is associated with poor prognosis in patients with clear cell adenocarcinoma of the ovary ...
TY - JOUR. T1 - Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells. T2 - Cytoplasmic sequestration of CDK2 by p27. AU - Itamochi, Hiroaki. AU - Yoshida, Tomokazu. AU - Walker, Cheryl Lyn. AU - Bartholomeusz, Chandra. AU - Aoki, Daisuke. AU - Ishihara, Hideki. AU - Suzuki, Nao. AU - Kigawa, Junzo. AU - Terakawa, Naoki. AU - Ueno, Naoto T.. PY - 2011/9. Y1 - 2011/9. N2 - Objective: Ovarian clear cell carcinoma (CCC) carries a poor prognosis because of its insensitivity to chemotherapy. We previously found an association between reduced proliferation of CCC and chemoresistance; here we investigated the mechanism of the reduced proliferation. Methods: We assessed cell cycle function by measuring the activity of cyclin-dependent kinases (CDKs) and the protein expression of cyclins, the CDK inhibitors, and p53 in 22 ovarian cancer cell lines and 60 human ovarian cancer specimens. We examined the cellular location of p27, p27 phosphorylated at threonine 157 (p27Thr157), and ...
Methylation of HIN-1 is associated with poor outcomes in patients with ovarian clear cell carcinoma (OCCC), which is regarded to be an aggressive, chemo-resistant histological subtype. This study aimed to evaluate whether 5-aza-2-deoxycytidine (5-aza-2-dC) can reverse methylation of the HIN-1 gene to restore chemo-sensitivity of OCCC and the possible mechanism. In vitro flow cytometric analysis and evaluation of caspase-3/7 activity of paclitaxel-sensitive and resistant OCCC cell lines were performed. Methylation status and expression changes of HIN-1 in the OCCC cell lines treated with 5-aza-2-dC were evaluated, and immunohistochemical staining of HIN-1 in OCCC tissues was performed. In vivo tumor growth with or without 5-aza-2-dC treatment was analyzed, and Western blotting of AKT-mTOR signaling-related molecules was performed. G2-M phase arrest was absent in paclitaxel-resistant OCCC cells after treatment with the cytotoxic drug. The caspase activities of the chemo-resistant OCCC cells were lower
Wolf-Hirschhorn syndrome candidate gene-1 (WHSC1), a histone methyltransferase, has been found to be upregulated and its expression to be correlated with expression of enhancer of zeste homolog 2 (EZH2) in several cancers. In this study, we evaluated the role of WHSC1 and its therapeutic significance in ovarian clear cell carcinoma (OCCC). First, we analyzed WHSC1 expression by quantitative PCR and immunohistochemistry using 23 clinical OCCC specimens. Second, the involvement of WHSC1 in OCCC cell proliferation was evaluated by MTT assays after siRNA-mediated WHSC1 knockdown. We also performed flow cytometry (FACS) to address the effect of WHSC1 on cell cycle. To examine the functional relationship between EZH2 and WHSC1, we knocked down EZH2 using siRNAs and checked the expression levels of WHSC1 and its histone mark H3K36m2 in OCCC cell lines. Finally, we checked WHSC1 expression after treatment with the selective inhibitor, GSK126. Both quantitative PCR and immunohistochemical analysis revealed that
Ovarian clear cell carcinoma is distinct from other epithelial ovarian cancers in terms of epidemiology, clinicopathological features, gene expression profile, and immune microenvironment. In the Western world, this is an uncommon disease and accounts for only 6% of epithelial ovarian cancer in the United States, but is far more prevalent in Singapore, the Republic of Korea, Taiwan, and Japan, where clear cell cancers constitute up to 25% of diagnosed ovarian cancer.1 2 Histologically, ovarian clear cell carcinoma is characterized by cells containing abundant clear glycogen-containing cytoplasm and may be associated with surrounding features of endometriosis. Immunohistochemistry typically demonstrates negativity for Wilms tumor 1 (WT1) and p53, but is often positive for hepatocyte nuclear factor 1-beta (HNF1-β).3. The treatment of women with advanced and recurrent ovarian clear cell carcinoma remains an area of significant unmet need. Clear cell ovarian cancers tend to occur in younger women ...
TY - JOUR. T1 - A New CA125‐like Antigen (CA602) Recognized by Two Monoclonal Antibodies against a Newly Established Ovarian Clear Cell Carcinoma Cell Line (RMG‐II). AU - Nozawa, Shiro. AU - Yajima, Masazumi. AU - Sasaki, Hirosuke. AU - Tsukazaki, Katsumi. AU - Aoki, Daisuke. AU - Sakayori, Motoko. AU - Udagawa, Yasuhiro. AU - Kobayashi, Toshifumi. AU - Sato, Ichiro. AU - Furusako, Shoji. AU - Mochizuki, Hiroshi. PY - 1991/7. Y1 - 1991/7. N2 - A cell line designated RMG‐II was established from the ascites of a patient with ovarian clear cell carcinoma. The chromosomal analysis revealed aneuploidy with a hypertetraploid modal numher and 8 marker chromosomes. Radioimmunoassay and immunocytochemical staining showed that RMG‐II cells produced some tumor markers such as CA125 and TPA. Two monoclonal antibodies, designated MA602‐1 and MA602‐6, were generated by immunization of mice with an extract prepared from the culture supernatant of RMG‐II cells. The epitopes recognized by these two ...
Purpose: Ovarian clear cell adenocarcinoma (OCCA) is an uncommon histotype that is generally refractory to platinum-based chemotherapy. We analyze here the most comprehensive gene expression and copy number data sets, to date, to identify potential therapeutic targets of OCCA.. Experimental Design: Gene expression and DNA copy number were carried out using primary human OCCA tumor samples, and findings were confirmed by immunohistochemistry on tissue microarrays. Circulating interleukin (IL) 6 levels were measured in serum from patients with OCCA or high-grade serous cancers and related to progression-free and overall survival. Two patients were treated with sunitinib, and their therapeutic responses were measured clinically and by positron emission tomography.. Results: We find specific overexpression of the IL6-STAT3-HIF (interleukin 6-signal transducer and activator of transcription 3-hypoxia induced factor) pathway in OCCA tumors compared with high-grade serous cancers. Expression of PTHLH ...
Clear cell adenocarcinoma of endobronchial origin is rare with only two case reports identified in a Pubmed search [1, 2]. Both of these reported cases occurred in adults, 45 years and 65 years of age. Our case is of a younger adult male of 27 years of age. The main differential diagnosis in this case is to rule out an adenocarcinoma with focal clear cell features, fetal adenocarcinoma, metastatic renal cell carcinoma, in additional to clear cell ("sugar") tumor. The immunohistochemical stains being negative for CK5/6 and P63, as well as TTF1 and napsin A would make a diagnosis of either a squamous cell carcinoma or adenocarcinoma with clear cell features unlikely. The renal cell markers are negative. Sugar tumors are classically HMB-45 positive, and therefore our tumor is not in that category. The positivity of CK7 and PAS/PAS-D support an epithelial origin with glycogen positive cytoplasm. In our case, as well as the two case reports, this type of clear cell adenocarcinoma is known for an ...
Introduction: Ovarian Clear Cell Carcinoma (OCCC) is generally aggressive and chemoresistant, with five year survival rate of approximately 40%. Recent mutation analysis has indicated a high frequency of PIK3CA mutations, the gene encoding for the p110α subunit in PI3K, in OCCC. Aberrant signaling of the PI3K/AKT pathway might be linked to the aggressiveness of OCCC. In this study, we investigated the sensitivity of ovarian clear cell carcinoma cells with different PIK3CA mutations to inhibitors targeting the PI3K signaling pathway.. Experimental design: To elucidate the functional roles of PIK3CA mutations in OCCC, 12 OCCC cell lines carrying PIK3CA wildtype or different PIK3CA mutations were used. By performing WST-1 assay, the IC50 values for cisplatin of the cell lines were compared. Eight stable OCCC cell lines expressing a luciferase reporter fused with a FOXO3a promoter were constructed. FOXO3a is a transcription factor that is exported out of the nucleus by AKT. The difference in the ...
Urethral cancer is a rare malignancy with urothelial subtype being the most common followed by adenocarcinoma. In women, the usual presentation is urinary retention and hematuria.
The patient received a potassium supplement, intramuscular administration of calcitonin, and intravenous (IV) fluid hydration, and she was admitted to the hospital for further workup. After treatment with IV fluids, calcitonin, and zoledronic acid, her calcium level decreased to 11.5 mEq/L. With improvement of her nausea and vomiting, the patient was discharged. It was recommended that she follow-up with an oncologist as an outpatient.. Approximately 1 week later, the patient returned to the Emergency Department with similar symptoms and was found to have an elevated calcium level of 15 mEq/L. She was given IV fluids and pamidronate, which improved her symptoms. She was discharged, with further workup to be done on an outpatient basis. This patient presented a total of 4 times to the Emergency Department with similar symptoms of hypercalcemia, as shown in Figure 1.. A bone marrow biopsy was performed, and the specimen demonstrated trilineage hematopoiesis without signs of myeloma. Specifically, ...
Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
What is Germ Cell Ovarian Cancer? Get the facts about Germ Cell Ovarian Cancer symptoms, testing, treatment and care options from trusted sources.
Clear cell carcinoma of the uterine cervix: clinical characteristics and feasibility of fertility-preserving treatment Xiang Jiang, Ying Jin, Yan Li, Hui-Fang Huang, Ming Wu, Keng Shen, Ling-Ya Pan Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China Abstract: The objective of this retrospective study was to analyze the clinical characteristics and prognosis of clear cell adenocarcinoma (CCA) in the post-diethylstilbestrol (DES) era and to evaluate the feasibility of fertility-preserving treatment. The records of 32 patients with CCAs who were treated at Peking Union Medical College Hospital from August 1986 to June 2012 were retrospectively reviewed. Three of the patients had undergone fertility-preserving treatment. The incidence of CCA among cervical adenocarcinomas was 15.2%. The median age was 38 years: 11 patients (34.4%) were diagnosed before 30 years of age
Clear cell adenocarcinoma (CCC), a subtype of epithelial ovarian cancer, is less sensitive to chemotherapy and is thus classified as a refractory ovarian cancer [1]. It has been shown that a combination of carboplatin (CBDCA) and paclitaxel (PTX ), a standard therapy for ovarian cancer [2, 3], is effective against serous adenocarcinoma and endometrioid adenocarcinoma, with a response rate of approximately 75%, while CCC has lower response rates ranging from 18% to 50% [4]. The incidence of CCC has been increasing and is now 25% in Japan, while that in Europe is 5-6%. As yet, no treatment for this histological subtype of ovarian cancer has been established. Histopathology remains the gold standard for classifying epithelial ovarian cancer subgroups; however, there is emerging evidence indicating different genetic and molecular profiles. Consequently, there is no international consensus regarding the necessity of establishing treatment strategies based on histological subtypes. In fact, global ...
PRIMARY OBJECTIVES:. I. To assess the activity of the study regimen as measured by the proportion of patients who are alive and progression-free for at least 12 months after study entry in patients with newly diagnosed stage III or IV clear cell ovarian cancer in the following populations: patients in the United States (U.S.) and worldwide (outside of Japan) and patients in Japan.. II. To compare progression-free survival in newly diagnosed stage III or IV clear cell ovarian cancer patients in patients in the U.S. and worldwide (outside of Japan) versus patients in Japan.. SECONDARY OBJECTIVES:. I. To characterize the duration of overall survival and progression-free survival in each population.. II. To examine the frequency and severity of adverse events as assessed by Common Terminology Criteria for Adverse Events (CTCAE) version 4 in each population.. III. To estimate the rate of objective tumor response in patients with measurable disease.. TERTIARY OBJECTIVES:. I. To explore whether ...
TY - JOUR. T1 - Salivary Clear Cell Carcinoma Clinicopathologic Characteristics and Outcomes. T2 - A Population-Based Analysis. AU - Sharbel, Daniel D.. AU - Unsal, Aykut A. AU - Groves, Michael W. AU - Albergotti, William Greer. AU - Byrd, James Kenneth. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background: Salivary clear cell carcinoma is an uncommon, low-grade malignancy for which limited data describing predictive clinicopathologic factors and treatment outcomes exist because of rarity. Methods: The authors queried the Surveillance, Epidemiology, and End Results database from 1982 to 2014. Multivariate Cox and Kaplan-Meier analyses were performed to determine disease-specific survival (DSS) and predictive clinicopathologic factors. Results: One hundred ninety-eight patients with salivary clear cell carcinoma were included. Overall incidence was 0.011 per 100 000 individuals, with no significant annual percentage change across years (−0.93%, P =.632). Five-, 10-, and 20-year DSS rates were 81.3% ...
One of my relatives was diagnosed with |b|cancer of the left kidney|/b|. The kidney has been removed three days back. The frozen section analysis revealed renal clear cell carcinoma. The histopathological report is awaited. What is clear cell carcinoma? Is it the more aggressive type or relatively milder? Can you please clarify this clear cell terminology?
Clear cell ovarian tumors are part of the surface epithelial-stromal tumor group of ovarian cancers, accounting for 6% of these cancers. Clear cell tumors are also associated with the pancreas and salivary glands. Typically, they are cystic neoplasms with polypoid masses that protrude into the cyst. On microscopic pathological examination, they are composed of cells with clear cytoplasm (that contains glycogen) and hob nail cells (from which the glycogen has been secreted). The pattern may be glandular, papillary or solid. Benign and borderline variants of this neoplasm are rare, and most cases are malignant. These tumors may have a worse prognosis than serous tumors. Chan JK, Teoh D, Hu JM, Shin JY, Osann K, Kapp DS (June 2008). "Do clear cell ovarian carcinomas have poorer prognosis compared to other epithelial cell types? A study of 1411 clear cell ovarian cancers". Gynecol. Oncol. 109 (3): 370-6. PMID 18395777. doi:10.1016/j.ygyno.2008.02.006. Clear Cell Carcinoma of Ovary at University of ...
TY - JOUR. T1 - Adnexal clear cell carcinoma with comedonecrosis. T2 - A case report. AU - Kim, Seo Hee. AU - Han, Sun Hee. AU - An, Jung Suk. AU - Lee, Ju-Han. AU - Lee, Eung Seok. AU - Park, Heum Rye. AU - Kim, Young Sik. PY - 2010/2/1. Y1 - 2010/2/1. N2 - Adnexal clear cell carcinoma with comedonecrosis (ACCCC) is a very rare malignancy of the skin with an aggressive clinical course and a predilection for the scalp. This is the first reported case of ACCCC in Korea. A 79-year-old male presented with left abdominal masses that proved to be two subcutaneous nodules. The tumors histologically consisted of epithelial nests that showed a distinctive zonal arrangement. The centrally located clear cell areas with comedonecroses were merged with the peripheral squamoid cells, often exhibiting retraction artifacts and an infiltrating border. Nuclear pleomorphism and frequent mitoses were prominent. The clear cells were immunopositive for carcinoembryonic antigen and epithelial membrane antigen. We ...
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To confirm that COP1 is overexpressed in these tumors at the protein level, immunohistochemistry analysis using a specific antibody to COP1 was done on the same ovarian tissue microarray described above as well as the ovarian samples used for RT-PCR in Fig. 2A ⇓ . The tissue microarray showed 47% (11 of 27) of serous adenocarcinomas, 63% (12 of 19) of endometrioid adenocarcinomas, 36% (4 of 11) of clear cell adenocarcinomas, and 50% (5 of 10) of mucinous adenocarcinomas displayed a robust COP1 immunoreactivity within the nuclear and cytoplasmic compartments of the malignant cells; however, no signal was detected within the stroma (Fig. 2C) ⇓ . In addition, normal tissues were negative for any reactivity with the COP1 antibody (data not shown). Collectively, these data indicate that COP1 mRNA and protein are specifically overexpressed in the malignant cells. There was relatively good agreement with the in situ hybridization and immunohistochemistry data (data not shown); however, endometrioid ...
DISEASE CHARACTERISTICS: Histologically confirmed advanced ovarian epithelial malignancy of one of the following histologies: Serous adenocarcinoma Endometrioid adenocarcinoma Mucinous adenocarcinoma Undifferentiated carcinoma Clear cell adenocarcinoma Mixed epithelial carcinoma Fallopian tube and extraovarian peritoneal papillary serous tumors also allowed Documented responsiveness (using established clinical criteria) to a platinum-based chemotherapy regimen required Partial or complete clinical response to the most recent chemotherapy regimen required Bone marrow aspirate and biopsy morphologically negative for carcinoma and cellularity greater than 50% No CNS involvement. PATIENT CHARACTERISTICS: Age: 18 to 65 Performance status: GOG 0-2 Life expectancy: Not specified Hematopoietic: WBC greater than 3,000/mm3 Absolute neutrophil count at least 1,500/mm3 Platelet count greater than 100,000/mm3 Hepatic: Bilirubin less than 1.5 mg/dL* SGOT less than 60 IU/mL* * Unless abnormality due to ...
The findings were published online by the journal Nature Medicine.. Ovarian cancer is divided into four different histological subtypes. One of the subtypes is ovarian clear cell carcinoma, which affects approximately 5 to 10 percent of American ovarian cancer patients and about 20 percent of patients in Asia. While most patients with ovarian cancer initially respond well to standard-care platinum-based chemotherapy, the response rate among those with the clear cell subtype is typically low and there is currently no effective therapy for these patients. This underscores the need for a new approach to treating this deadly disease.. "One of the significant challenges with the treatment of ovarian cancer is finding a suitable target that effectively halts the progression of the disease in a personalized manner based on ones genetic makeup," said Rugang Zhang, Ph.D., associate professor in Wistars Gene Expression and Regulation Program and corresponding author of the study. "With this study, we ...
1. Akan H, Küçük M, Balat Ö, et al. The diagnostic value of cranial computed tomography in complicated eclampsia. Journal Belge de Radiologie (JBR-BTR) 1993; 76: 304-306. 2. Kökçü A, Üstün C, Balat Ö, et al. Basal Ganglia and white matter in pregnancy-induced hypertension. Neuroradiology 1993 ; 35: 284-5. 3. Sönmez S, Kafkaslı A, Balat Ö, et al. Cervical pregnancy: can age and parity be predisposing factors? Acta Obstet Gynecol Scand 1994; 73: 734-6. 4. Balat O, Kudelka AP, Edwards CL, et al. Malignant transformation in endometriosis of the urinary baldder : a case report of clear cell adenocarcinoma. Eur. J. Gynaec. Oncol 1995;1:13-16. 5. Kavanagh JJ, Edwards CL, Freedman RS, Finnegan MB, Balat O, et al. A trial of loboplatin (D-19466) in platinum-resistant ovarian cancer. Gynecologic Oncology 1995; 58:106-109. 6. Soysal O, Balat O, Kudelka AP, et al. Oncogene and tumor supressor gene therapy for cancer. Cancer Molecular Biology (CMB) 1995; 4:591-596. 7. Balat O, Verschraegen C. ...
... Clear cell adenocarcinoma of the vagina and cervix is rare. The increase and occurrence of this tumor has been linked with the maternal use of
The first complex isolated was SWI/SNF in yeast[4], with the catalytic subunit being identified as SNF2. In humans, 3 homologues of SWI/SNF proteins have been identified; hbrm and BRG1, which are homologous of SNF2/SWI2 and hSNF5, which is a homologue of SNF5[5]. Hbrm and BRG1 promote transcriptional activation via the glucocorticoid and retonic acid receptors[6]. BRG1 has been found to activate or repress nuclear processes (transcription, elongation, DNA replication), using various mechanisms including being assembled with transcriptional promoters and histone-modifying enzyme complexes[7]. As SWI/SNF plays a key role in the cell cycle, it has been indicated to be a potent tumour suppressor. Mutations within subunits of these complexes have been linked to more than 20% of human cancers[8]. " The cancers with the highest SWI/SNF mutation rates were ovarian clear cell carcinoma (75%), clear cell renal cell carcinoma (57%), hepatocellular carcinoma (40%), gastric cancer (36%), melanoma (34%), and ...
Kulaberoglu, Yavuz; Lin, Kui; Holder, Maxine; Gai, Zhongchao; Gomez, Marta; Assefa Shifa, Belul; Mavis, MerdiyeHoa, LilySharif, Ahmad ADLujan, CeliaSmith, Ewan StBjedov, IvanaTapon, NicolasWu, GengHergovich, Alexander et al. (2017-09-25) ...
Ovarian Cancer News ; Daily Ovarian Cancer updates from hundreds of medical resources. Ovarian Cancer digests, journals, abstracts, breaking news, clinical trials, research, genetics,new drugs, trials, Chemotherapy, In the News drugs on the Horizon, daily updates on Ovarian Cancer information & Medical news. Resources. Blog Keeper; Khrissy Lupinacci Diagnosed 3/06/02 at age 38 with stage 3 C Clear Cell Ovarian Cancer. [email protected] ...
Ovarian Cancer News ; Daily Ovarian Cancer updates from hundreds of medical resources. Ovarian Cancer digests, journals, abstracts, breaking news, clinical trials, research, genetics,new drugs, trials, Chemotherapy, In the News drugs on the Horizon, daily updates on Ovarian Cancer information & Medical news. Resources. Blog Keeper; Khrissy Lupinacci Diagnosed 3/06/02 at age 38 with stage 3 C Clear Cell Ovarian Cancer. [email protected] ...
I am a 57 year old woman diagnosed with Stage 1c clear cell ovarian cancer. My doctor is recommending 3 cycles of carbo/taxol. Im concerned that 6 cycles would be better, particularly since it is cl...
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
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LMcMurryPew - Family/Friend: Head & Neck/Throat Cancer > Adenocarcinoma > Clear Cell Carcinoma Patient Info: Newly diagnosed (has not begun treatment), Diagnosed: over 7 years ago, Female, Age: 38, Stage II
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Tuning them in. Like I am some sort of human TV? Wow. As for the Navis as I like to call them they arent like little clear cells, however I do see that two sometimes. However I only see the cells when I look at electric sources, like light bulbs. I naturally assumed that I was looking at electrons. The Navis on the other hand I been seeing those long before I saw the static. Years ago I even asked my mother what they were, she claimed I was seeing Elementals, actual fairies in laymans terms ...
Primary signet cell carcinoma of the prostate is a rare histological variant of prostate malignancies. It is commonly originated from the stomach, colon, pancreas, and less commonly in the bladder. Prognosis of the classical type is worse than the adenocarcinoma of the prostate. Primary signet cell adenocarcinoma is diagnosed by eliminating the adenocarcinomas of other organs such as gastrointestinal tract organs. In this case report, we present a case with primary signet cell adenocarcinoma of the prostate who received docetaxel chemotherapy because of short prostate specific antigen doubling time ...
Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high ARID1A mutation rates. Here we present a mutant mouse model o...
Gynecological malignancies (ovarian clear cell and endometrioid carcinomas, endometrial serous, endometrioid and clear cell carcinomas) harbor somatic mutations in the gene PPP2R1A, the scaffolding subunit of the serine/threonine protein phosphatase 2A (PP2A) complex. The PP2A complex is composed of an A (scaffold), C (catalytic) subunit, and different B (regulatory) subunits. The PPP2R1A mutations are proposed to play a role in PP2A B-subunit binding, and thus formation of a functional PP2A phosphatase complex. The aim of this study is to determine how PPP2R1A mutations affect the binding of B-subunits and other novel interactions within the context of ovarian and endometrial carcinomas.. The ovarian clear cell line RMG2 and endometrial carcinoma cell lines Hec-1-A and Hec50 all harbor PPP2R1A mutations. The mismatch repair deficient cell line Hec-1-A express a PPP2R1A W257L heterozygous mutation; therefore somatic cell knockout technology was used to generate isogenic PPP2R1A clones that ...
To identify proteins involved in ovarian clear cell carcinoma (OCCCa), shotgun proteomics analysis was applied using formalin-fixed and paraffin-embedded samples of ovarian carcinoma. Analysis of 1521 proteins revealed that 52 were differentially expressed between four OCCCa and 12 non-OCCCa samples. Of the highly expressed proteins in OCCCa, we focused on left-right determination factor (LEFTY), a novel member of the transforming growth factor-β superfamily. In 143 cases of ovarian epithelial carcinoma including 99 OCCCas and 44 non-OCCCas, LEFTY expression at both mRNA and protein levels was significantly higher in OCCCas compared with non-OCCCas, with the mRNA expression of LEFTY1 being predominant compared to that of LEFTY2 ...
臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of "NTU Repository" with "Academic Hub" to form NTU Scholars.. ...
The cohort included 110 patients with a total of 121 masses. The mean tumor size was 2.4 cm, and 50% of the lesions were clear cell carcinoma.. The mpMRI studies were performed on both 1.5-tesla and 3-tesla MRI scanners at several institutions. Sequences included T2-weighted, axial chemical shift T1-weighted, and dynamic contrast enhanced T1-weighted imaging. Because diffusion-weighted MR images were routinely acquired at UT Southwestern -- but not always at other facilities -- the researchers did not evaluate results using that sequence (Journal of Urology, October 2017, Vol. 198:4, pp. 780-786).. Seven radiologists independently reviewed the results; the radiologists had different levels of experience and were blinded to the final pathology findings. Their task was to rank the likelihood of clear cell carcinoma on a six-point scale, with 1 as "definitely not" cancer and 5 as "definitely" cancer.. By setting a parameter score of 4 or greater for clear cell carcinoma, the researchers achieved ...
The researchers genetically engineered a strain of mice to make either Myc or another cancer-associated protein called Ras in the proximal tubules of the kidney when a compound called doxycycline, which had been added to their drinking water, was removed from it. (Myc and Ras are not normally produced at high levels by these cells.) Ras-producing mice did not get cancer. But within just a few weeks, the mice that made Myc developed kidney cancers that mimicked an aggressive subset of human renal cell adenocarcinoma that originates in the kidneys collecting ducts. Adding doxycycline back to the animals water caused the tumors to shrink dramatically.. The researchers then turned to a new tissue analysis technique called desorption electrospray ionization mass-spectrometric imaging, or DESI-MSI, recently developed by postdoctoral scholar Livia Eberlin, PhD, in the Zare laboratory to compare cancerous and normal tissue.. DESI-MSI creates a highly detailed, two-dimensional map of the chemical ...
Bašić-Jukić, Nikolina and Hudolin, Tvrtko and Radić-Antolić, Margareta and Ćorić, Marijana and Zadro, Renata and Kaštelan, Željko and Pasini, Josip and Bandić-Pavlović, Daniela and Kes, Petar (2011) Bone morphogenetic protein-7 expression is down-regulated in human clear cell renal carcinoma. Journal of Nephrology, 24 (1). pp. 91-97. ISSN 1121-8428 Bilić, Marija and Munjas-Samarin, Radenka and Ljubanović, Danica and Horvatić, Ivica and Galešić, Krešimir (2011) Effects of ramipril and valsartan on proteinuria and renal function in patients with nondiabetic proteinuria. Collegium Antropologicum, 35 (4). pp. 1061-6. ISSN 0350-6134 ...
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These tumours are frequently low grade, associated with oestrogen exposure, and present at a less advanced stage. Endometroid adenocarcinomas show a variety of appearances depending on grade. Most are well-differentiated, showing glandular structures without intervening stroma. There is little atypia of cells and extracellular mucin may be present. Areas of squamous differentiation may be present. Higher grade tumours may have bizzare cells present; it is important to ensure that serous or clear cell carcinomas are not present. Higher grade lesions show less defined architecture.. ...
Epidermal-derived: Clear cell acanthoma ; Bowens disease ; Basal cell carcinoma. Adnexal tumours: Pagets disease; Clear cell syringoma ; Clear cell hidradenoma ; Clear cell hidradenocarcinoma ; Clear cell porocarcinoma ; clear cell myoepithelioma;. Tricholemmoma ; Tricholemmal carcinoma ; Sebaceous adenoma ; Sebaceous carcinoma.. Nevomelanocytic: Balloon cell nevus ; Balloon cell melanoma ; Clear cell melanoma ; Clear cell sarcoma.. Mesenchymal: Clear cell dermatofibroma; Clear cell atypical fibroxanthoma ; Clear cell fibrous papule.. Salivary gland: Acinic cell carcinoma; Hyalinizing clear cell carcinoma ; Clear cell mucoepidermoid carcinoma.. Metastases: Renal cell carcinoma ; Breast carcinoma ; Hepatocellular carcinoma ; Pulmonary adenocarcinoma and mesothelioma.. Clear cell carcinoma of Skin: 1. Clear cell (hydropic) basal cell carcinoma and squamous cell carcinoma 2. Clear cell variant of Atypical fibroxanthoma. 3. Clear cell porocarcinoma 4 Hidradenocarcinoma. 5. Sebaceous carcinoma 6. ...
The timing and location of the DES (Diethylstilbestrol) symposium have historical significance. In the late 1960s, there was an unprecedented appearance of a rare vaginal cancer in young women. Cases of Clear Cell Adenocarcinoma (CCA) were diagnosed in an age group never before found to develop it. A DES mother raised the question of whether her daughters vaginal cancer might be connected to DES exposure in utero. Doctors confirmed the link between DES and cancer in 1971 and published their findings in the April 1971 issue of the New England Journal of Medicine. It is at the MGH that the DES cancer link was first made on April 22, 1971.. In 2011, in the USA and in many other corners of the world, diethylstibestrol continues to affect the lives of not only the DES mothers who were prescribed the carcinogenic drug, the lives of their daughters and sons who have been exposed in utero, but also the lives of their grandchildren. And unfortunately, cancer is not the only health issue that has been ...
The timing and location of the DES (Diethylstilbestrol) symposium have historical significance. In the late 1960s, there was an unprecedented appearance of a rare vaginal cancer in young women. Cases of Clear Cell Adenocarcinoma (CCA) were diagnosed in an age group never before found to develop it. A DES mother raised the question of whether her daughters vaginal cancer might be connected to DES exposure in utero. Doctors confirmed the link between DES and cancer in 1971 and published their findings in the April 1971 issue of the New England Journal of Medicine. It is at the MGH that the DES cancer link was first made on April 22, 1971.. In 2011, in the USA and in many other corners of the world, diethylstibestrol continues to affect the lives of not only the DES mothers who were prescribed the carcinogenic drug, the lives of their daughters and sons who have been exposed in utero, but also the lives of their grandchildren. And unfortunately, cancer is not the only health issue that has been ...
Human Kidney Slide (Clear Cell Renal Cell Carcinoma) (5 slides/pk) Slide for IHC HTS-10405 Human Kidney Slide (Clear Cell Renal Cell Carcinoma) (5 slides/pk) Slide for IHC HTS-10405
Worldwide, renal carcinoma constitutes 3% of all forms of cancer in the human body. Its biological behavior is variable depending on the biology of each individual; it tends to metastasize to contiguous sites such as adrenal glands, liver, lung, bone, lymph nodes, however, remote presentation in the oral cavity is less frequent, even in inserted gums. Granulomatous lesions of the periodontium include pyogenic granulomas, giant cell granulomas among others. The main objective of this clinical case is to describe the clinical and histopathological characteristics of oral cavity metastases as granulomatous lesions. The case of a 60-year-old female patient with a history of renal cell papillary carcinoma in the right kidney treated by nephrectomy in 2017 is presented, in 2019 she presented metastases to the left lung and oral cavity. It is currently under treatment protocol for renal clear cell metastases.. ...
article{11496274-1e4f-4d54-9c1e-77bd2d6d93df, abstract = {,p,Renal cell carcinoma (RCC), arising from the proximal tubule in the kidney, accounts for approximately 85% of kidney cancers and causes over 140,000 annual deaths worldwide. In the last decade, several new therapies have been identified for treatment of metastatic RCC. Although these therapies increase survival time compared to standard care, none of them has curative properties. The nephrotoxin orellanine specifically targets proximal tubular epithelial cells, leaving other organs unaffected. We therefore hypothesized that the selective toxicity of orellanine extends to clear cell RCC (ccRCC) cells since they emanate from proximal tubular cells. Orellanine would thus target both primary and metastatic ccRCC in vitro and in vivo. We found that orellanine induces dose-dependent cell death in proximal tubular cells and in all ccRCC cells tested, both primary and cell lines, with no toxicity detected in control cells. The toxic action of ...
Background Sunitinib has become mainstay first line treatment for patients with metastatic renal clear cell carcinoma (mRCC). Still, useful predictive markers of response are lacking and urgently needed for clinical decision making. Methods In the present study we investigated the predictive value of standard serum markers as well as clinical markers, including C-reactive protein (CRP), Neutrophil to Lymphocyte ratio (NLR) and early hypertension (eHTN) in an unselected prospective patient population treated with sunitinib for mRCC. Forty-six patients were enrolled in a prospective single-arm study of predictive markers for sunitinib response. Response rates according to RECIST 1.1 were used as primary end-point. Secondary objectives were to evaluate prognostic value of the candidate markers with regard to progression free survival (PFS) and overall survival (OS). In addition, toxicity rates and quality of life was recorded. Results Median PFS and OS was 9.1 months and 15.0 months, respectively. ...
Looking for online definition of clear cell acanthoma in the Medical Dictionary? clear cell acanthoma explanation free. What is clear cell acanthoma? Meaning of clear cell acanthoma medical term. What does clear cell acanthoma mean?
Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of renal cell carcinoma, and immune-related genes (IRGs) are key contributors to its development. In this study, the gene expression profiles and clinical data of ccRCC patients were downloaded from The Cancer Genome Atlas database and the cBioPortal database, respectively. IRGs were obtained from the ImmPort database. We analyzed the expression of IRGs in ccRCC, and discovered 681 that were differentially expressed between ccRCC and normal kidney tissues. Univariate Cox regression analysis was used to identify prognostic differentially expressed IRGs (PDEIRGs). Using Lasso regression and multivariate Cox regression analyses, we detected seven optimal PDEIRGs (PLAU, ISG15, IRF9, ARG2, RNASE2, SEMA3G and UCN) and used them to construct a risk model to predict the prognosis of ccRCC patients. This model accurately stratified patients with different survival outcomes and
Background: Caspase 4 (CASP4) dysregulation is related to the occurrence, development, and outcome of many malignant tumors, but its role in clear cell renal cell carcinoma (ccRCC) is unclear. This study was conducted to investigate the expression level of CASP4 in tumor tissu...
X4 Pharmaceuticals, a clinical stage biotechnology company developing novel CXCR4 antagonists to improve immune cell trafficking to treat cancer and rare disease, today announced results from a pilot study of X4P-001-IO in combination with Opdivo (nivolumab) in patients with clear cell renal cell carcinoma who are non-responsive to the anti-PD-1 checkpoint inhibitor Opdivo alone.
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Studies of pembrolizumab have shown promising antitumor activity across a wide cohort of patients with clear cell renal cell carcinoma (ccRCC). The results of a recent study, named KEYNOTE-427, showed a favorable safety profile, similar to that established in other trials focused on other tumor types. In this study, pembrolizumab was used as...
Renal cell carcinoma is the most common type of kidney cancer. It is also known as RCC, renal cell carcinoma, or renal cell adenocarcinoma. It accounts for more than 9 out of 10 cases of kidney cancer. Like all cancers, kidney cancer begins small and grows larger over time. It usually grows as a single mass or tumor within the kidney. But a kidney can have more than one tumor. Sometimes tumors are found in both kidneys at the same time. Kidney tumors are often found on CT scans or ultrasounds being done for concerns other than kidney cancer. The cancer might be found only after it has become very large. Most of the time it is found before it has spread to other organs. This is good because like most cancers, kidney cancer can be hard to treat after it has spread.. ...
786-O Cell Avalanche™ Transfection Reagent (human kidney adenocarcinoma cell),Will be provided with the purchase of the reagent.,Cell Line,Epithelial Cell,Kidney,Cancer,Adherent,Human,786-O, 786-0, CRL-1932, kidney, renal cell adenocarcinoma, pth, caucasian, RD Williams, NCI60, NCI-60,
The SWI/SNF complex contains 12-15 subunits [1-3], which are combinatorially assembled to create as many as several thousand biochemically distinct complexes. In development, changes to composition of SWI/SNF can drive developmental progression [4, 5]. In cancer, SWI/SNF is among the most commonly found mutations, with mutations observed in as many as 20% of tumors [6, 7]. However, these mutations are not equally spread across the subunits. Mutations in the ARID family members (ARID1A, ARID1B and ARID2) and the ATPase subunits (BRG1 and BRM) are more prevalent than in the other subunits [6, 7]. Additionally, in some cancers multiple subunits are mutated. This is the case in hepatocellular carcinoma where mutations have been identified in all three ARID subunits [8-10]. In other cancers, mutations are highly specific, such as BRG1 mutations in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) [11] and SNF5 mutations in malignant rhabdoid tumors [12], and ARID1A in ovarian clear cell ...
This cancer presented in a 40-year-old woman complaining of abdominal pain. Endoscopically it was a very suspicious ulcer. Biopsy showed diffusely infiltrating signet ring cell adenocarcinoma. These are gross photos of the subtotal gastrectomy specimen. The photo above is asen face view of the ulcer. The pyloric margin is to the left. The ulcer is seen on the lesser curvature. Courtesy: Ed Uthman.. ...
BACKGROUND: Previous studies combining PD-1 checkpoint inhibitors with tyrosine kinase inhibitors of the VEGF pathway have been characterised by excess toxicity, precluding further development. We hypothesised that axitinib, a more selective VEGF inhibitor than others previously tested, could be combined safely with pembrolizumab (anti-PD-1) and yield antitumour activity in patients with treatment-naive advanced renal cell carcinoma. METHODS: In this ongoing, open-label, phase 1b study, which was done at ten centres in the USA, we enrolled patients aged 18 years or older who had advanced renal cell carcinoma (predominantly clear cell subtype) with their primary tumour resected, and at least one measureable lesion, Eastern Cooperative Oncology Group performance status 0-1, controlled hypertension, and no previous systemic therapy for renal cell carcinoma ...
RESULTS : Our study showed significantly greater expression of pERK in CCRCC than in non-neoplastic renal parenchyma. pERK-high expression was significantly associated with a low pT category (P = .046). The survival analysis showed a significant association between pERK-high expression and better progression-free survival (P = .014). Furthermore, the prognostic significance of pERK expression was quite different between small CCRCC (size ≤7 cm) and large CCRCC (size ,7 cm) lesions. In small CCRCC, pERK-high expression correlated significantly with better cancer-specific survival (P = .018) and better progression-free survival (P , .001). However, no correlation was found between pERK expression and survival in large CCRCC ...
Donors gave 64 units of blood in a campus drive April 20 and 21, said Coree Toole, Oklahoma Blood Institute site supervisor.. A total of 105 students and staff volunteered to donate but about 40 were unable to do so for various reasons.. It is typical for some donors not to qualify for donating blood, Toole said. Sometimes the persons iron may be too high or too low, causing the blood to be useless.. Traveling to certain countries, such as Mexico, may disqualify a donor, he said, because of the risk of malaria. Health problems that call for using certain medication or antibiotics can cause a donor to be unable to give, Toole said.. The blood received from OCCC will be given to local hospitals to help save lives, Toole said. One blood donation can help up to three people, according to the OBI web site.. Founded in 1977, the Oklahoma Blood Institute is now the ninth largest non-profit blood center in America with more than 125,000 donors a year.. "We really appreciate you having us (on campus) ...
https://doi.org/10.18632/oncotarget.15162 Zhen Chen, Yingjie Shao, Hongwei Yao, Qianfeng Zhuang, Kun Wang, Zhaoyu Xing, Xianlin Xu, Xiaozhou He, Renfang Xu
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
Every Week the Editor-in-Chief selects an Article of the Week from the current issue of BJUI. The abstract is reproduced below and you can click on the button to read the full arti[...] ...
TY - JOUR. T1 - Clear cell primary seminal vesicle carcinoma in a young male-a rare case report. AU - Gaur, Saurabh. AU - Pillai, Sunil B.. AU - Hegde, Padmaraj. AU - Chawla, Arun Kumar. AU - Kapadia, Aseem. PY - 2018/2/1. Y1 - 2018/2/1. N2 - Primary malignancies of Seminal Vesicle (SV) are rare. When involved, it is most commonly due to secondaries or by contiguous spread from adjacent organs. Primary tumours that can arise in SV can be epithelial and mesenchymal. Adenocarcinoma is most common epithelial tumour, and the Clear Cell variant of Adenocarcinoma (CCA) so far has not been reported in literature. Primary SV malignancies like adenocarcinoma pose a diagnostic dilemma as it becomes difficult to differentiate it from secondaries or as involvement from other adjacent organs even with imaging, histopathology and Immunohistochemistry (IHC). Here we present a case of 34-year-old male who presented with occasional total painless haematuria for four years and was evaluated by Contrast Enhanced ...
Thirty five mRCC pts, median (range) age = 61y (28-78y), sex-ratio = 29/6 were included. Ev was received as: 2nd or 3rd line = 60%, >3rd line = 37%. All pts had clear cell carcinoma except 2 patients with either chromophobe or papillary carcinoma. IMDC prognostic groups were distributed as follows: "Good"= 7 (20%), "Intermediate" = 23 (66%) and "Poor" = 5 (14%). SMI (cm2/m2) was normally distributed: median (range) = 43.4 (24.2-67.7). Continuous SMI at baseline was significantly associated with OS both in univariate analysis: HR (for 1 standard deviation unit = 8.66 cm2/m2) = 0.57, (95%CI = 0.36-0.91) and after adjustment on IMDC prognostic group (HR = 0.62, 95%IC = 0.39-1.00). Neither adjustment on BMI or NPL did change the HR of the continuous SMI. Comparison of first (T1) and last terciles (T3) of SMI (12 pts each) revealed that OS was longer for pts with the highest SMI: 20.2m (16.1-43.6) vs. 6.6m (5.9-17.9), HR (T3/T1) = 0.42, 95%IC = 0.16-1.06 (p = 0.067). ...
Teaching Files with CT Medical Imaging and case studies on Anatomical Regions including Adrenal, Colon, Cardiac, Stomach, Pediatric, Spleen, Vascular, Kidney, Small Bowel, Liver, Chest | CTisus
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Background To examine the expression of type 1 plasminogen inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC), and its possible association with microvessel density (MVD), the expression of thrombospondin-1 ...
Kinases altered in CC-RCC and relationship to clinical outcome.CC-RCC tumors that had matched normal fresh frozen material available (n = 12) were directly comp
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Build: Sat Feb 17 08:59:16 EST 2018 (commit: 16064c5). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
Hi, a little bit of background - 27 yr. old female. Drink once a week and ex-smoker. Medications currently taking Multi-vitamin w/ numerous supplements, Nasonex, Xananx on occassion, Allegra-D on occa...
Immune cells such as neutrophils and monocytes enter tissues after tissue damage and clear cell debris to allow repair cells such as fibroblasts to close the wound. Monocytes also differentiate into fibroblast-like cells ...
Endometrioid adenocarcinoma no [18] Mesonephric adenocarcinoma [18] Clear cell adenocarcinoma no [16][17][18] ... Micrograph of a small-cell carcinoma showing cells with nuclear moulding, minimal amount of cytoplasm and stippled chromatin. ... Micrograph showing the yolk sac component of a mixed germ cell tumour. H&E stain. ... a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears ...
Association with clear cell adenocarcinoma in diethylstilbestrol-exposed offspring". Cancer. 54 (5): 869-875. doi:10.1002/1097- ... It is sometimes considered a precancerous lesion, given clear-cell adenocarcinoma patients present these lesions in close ... "Adenocarcinoma of the vagina in adolescence.A report of 7 cases including 6 clear-cell carcinomas (so-called mesonephromas)". ... Relationship to genital tract clear cell adenocarcinoma and vaginal adenosis in daughters". American Journal of Obstetrics and ...
... cancers such as clear cell adenocarcinomas; cervical ridges and hoods; and development of a cockscomb cervix appearance. ... while the ectocervix is covered with multiple layers of cells topped with flat cells. The two types of epithelia meet the ... The cervical canal is a passage through which sperm must travel to fertilize an egg cell after sexual intercourse. Several ... Cervical ectropion refers to the horizontal overgrowth of the endocervical columnar lining in a one-cell-thick layer over the ...
... cancers such as clear cell adenocarcinomas; cervical ridges and hoods; and development of a cockscomb cervix appearance.[56] ... while the ectocervix is covered with multiple layers of cells topped with flat cells. The two types of epithelia meet the ... The cervical canal is a passage through which sperm must travel to fertilize an egg cell after sexual intercourse. Several ... The endocervical mucosa is about 3 millimetres (0.12 in) thick, lined with a single layer of columnar mucous cells, and ...
2008). "Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma". ... Cell. Biol. 29 (1): 20-30. doi:10.1128/MCB.00544-08. PMC 2612482 . PMID 18936159. Wang Y, Fu W, Xie F, et al. (2010). "Common ... Cell Genet. 66 (2): 96-8. doi:10.1159/000133675. PMID 8287691. Guey LT, García-Closas M, Murta-Nascimento C, et al. (2010). " ... 2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell ...
Adenocarcinoma is more likely to spread to the lungs and lymph nodes. Clear cell adenocarcinoma occurs in a small percentage of ... squamous-cell carcinoma and adenocarcinoma. Vaginal squamous-cell carcinoma arises from the squamous cells (epithelium) that ... Approximately one in 1,000 (0.1%) DES Daughters will be diagnosed with clear cell adenocarcinoma. The risk is virtually non- ... Vaginal adenocarcinoma arises from the glandular (secretory) cells in the lining of the vagina that produce some vaginal fluids ...
"Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses ... expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of ... "Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells ...
... of class III beta-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma". Clinical ... However, there are also data in clear cell carcinoma, melanoma and breast cancer showing favorable prognosis. Class III β- ... Cell. 140 (1): 74-87. doi:10.1016/j.cell.2009.12.011. PMC 3164117 . PMID 20074521. André N, Braguer D, Brasseur G, Gonçalves A ... Sieber-Blum M, Schnell L, Grim M, Hu YF, Schneider R, Schwab ME (2006). "Characterization of epidermal neural crest stem cell ( ...
On histology, the tumors consist of adenocarcinoma (endometrioid, serous or clear cell) mixed with the malignant mesenchymal ( ... or that the tumor is the result of a stem cell that differentiates into different cell types (the "combination" theory). " ... first from a stem cell into a population of cells, that then differentiates into epithelial and stromal components. There is ... As with endometrial carcinomas, the prognosis is influenced by the grade and type of the adenocarcinoma, being poorest with ...
DES has been linked to a variety of long-term adverse effects, such as increased risk of vaginal clear-cell adenocarcinoma, ... University of Chicago DES Registry of patients with CCA (clear cell adenocarcinoma) of the vagina and/or cervix. ... published in the New England Journal of Medicine showed a probable link between DES and vaginal clear cell adenocarcinoma in ... DES was shown to cause clear cell carcinoma, a rare vaginal tumor, in girls and women who had been exposed to this medication ...
Hobnail cells are found in clear cell ovarian adenocarcinoma, collecting duct carcinoma, and in end-stage cirrhosis. Kumar, ... In histopathology, a hobnail cell is a cell with a characteristic appearance, including a bulbous nucleus and nuclear ...
Subsequent studies have shown an approximate 40-fold increased risk of vaginal/cervical clear cell adenocarcinoma in women ... clear cell adenocarcinoma) of the vagina and/or cervix. DES Diethylstilbestrol Provides resources and social media links for ... who had been diagnosed with vaginal clear cell adenocarcinoma had been exposed prenatally to DES. ... In 1971, DES was shown to cause clear cell carcinoma, a rare vaginal tumor, in girls and women who had been exposed to this ...
Most cancers in the renal tubule are renal cell carcinoma and clear cell adenocarcinoma. Most cancers in the renal pelvis are ... These include: Clear cell adenocarcinoma Transitional cell carcinoma Inverted papilloma Renal lymphoma Teratoma Carcinosarcoma ... Squamous cell carcinoma Juxtaglomerular cell tumor (reninoma) Angiomyolipoma Bellini duct carcinoma Clear-cell sarcoma of the ... In the second line setting, nivolumab demonstrated an overall survival advantage in advanced clear renal cell carcinoma over ...
... a synthetic estrogen used from the 1940s to 1971 when the prenatal exposition has been linked to the clear-cell adenocarcinoma ... Male germ cells mutate at a much faster rate than female germ cells, and as the father ages, the DNA of the germ cells mutates ... This is because, as humans age, male germ cells acquire mutations at a much faster rate than female germ cells. Around a 5% ... Cigarette smoke acts as a chemical mutagen on germ cell DNA. The germ cells suffer oxidative damage, and the effects can be ...
... as well as the more aggressive uterine papillary serous carcinoma and uterine clear-cell carcinoma. Endometrial stromal ... These include the common and readily treatable well-differentiated endometrioid adenocarcinoma, ... Estrogen receptors, known to be present on the surfaces of the cells of this type of cancer, are thought to interact with the ... Endometrial carcinomas originate from cells in the glands of the endometrium (uterine lining). ...
... clear cell kidney carcinoma, breast ductal carcinoma, renal cell carcinoma, cervical cancer (squamous), colon adenocarcinoma, ... Renal cell carcinoma (Focus on but not limited to clear cell subtype) European Union/United Kingdom: Breast Cancer - ER+ve, ... pancreatic ductal adenocarcinoma, acute myeloid leukemia, prostate adenocarcinoma, lung adenocarcinoma, cutaneous melanoma, ... stomach adenocarcinoma, rectal carcinoma, hepatocellular carcinoma, Head and neck (oral) squamous cell carcinoma, thyroid ...
... and clear cell renal cell cancer in which high tissue IGFBP-3 expression has been linked to poor prognostic features or patient ... significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma". ... IGFBP-3 also interacts with cell-surface proteins, affecting cell signaling from outside the cell or after internalization, and ... "Altered expression of members of the IGF-axis in clear cell renal cell carcinoma". Int. J. Oncol. 26: 923-31. doi:10.3892/ijo. ...
Signet ring/round clear cells [6]. *GI stromal tumor (Krukenberg)[6]. Molecular biology[edit]. The cytokeratins are encoded by ... Adenocarcinomas originating from those above[6]. Cytokeratin 10 *Keratinized stratified epithelium. *Differentiated areas of ... Cytokeratins interact with desmosomes and hemidesmosomes, thus collaborating to cell-cell adhesion and basal cell-underlying ... Cell Biol. 8 (7): 562-73. doi:10.1038/nrm2197. PMID 17551517.. *^ Franke WW, Schmid E, Osborn M, Weber K (June 1979). " ...
... distinct cell membranes. The p53 cell signaling system is not active in endometrial clear cell carcinoma. This form of ... Higher-grade endometrioid adenocarcinomas have less well-differentiated cells, have more solid sheets of tumor cells no longer ... Histologically, it is characterized by the features common to all clear cells: the eponymous clear cytoplasm when H&E stained ... Usually, when cells grow old or get damaged, they die, and new cells take their place. Cancer starts when new cells form ...
Clear-cell adenocarcinomas are histopathologically similar to other clear cell carcinomas, with clear cells and hobnail cells. ... They are typically early-stage and therefore curable by surgery, but advanced clear-cell adenocarcinomas (approximately 20%) ... Usually, when cells grow old or get damaged, they die, and new cells take their place. Cancer starts when new cells form ... Germ cell tumors of the ovary develop from the ovarian germ cells. Germ cell tumor accounts for about 30% of ovarian tumors, ...
Bichler, who at 17 had developed clear cell adenocarcinoma of the cervix and vagina requiring the removal of her reproductive ...
... carcinoma Adenoid cystic carcinoma Polymorphous low-grade adenocarcinoma Epithelial-myoepithelial carcinoma Clear cell ... not otherwise specified Basal cell adenocarcinoma Sebaceous carcinoma Sebaceous lymphadenocarcinoma Cystadenocarcinoma Low- ... MRI Biopsy: The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of ... tissue tumors Hemangioma Hematolymphoid tumors Hodgkin lymphoma Diffuse large B-cell lymphoma Extranodal marginal zone B cell ...
... is medical jargon for cirrhosis of the liver Cellular morphology pathognomonic for clear cell adenocarcinoma of the ovary. ...
... was found to be causing an incredibly rare vaginal cancer known as clear-cell adenocarcinoma in young girls when the cancer was ...
... clear cell adenocarcinoma - clear-cell sarcoma - clear cell sarcoma of the kidney - clinical breast exam - clinical resistance ... cell - cell differentiation - cell motility - cell proliferation - cell respiration - cell adhesion - cellular adoptive ... systemic therapy T cell - T-3 - T-cell depletion - T-cell lymphoma - T138067 - T4N5 liposomal lotion - T900607 - TAC-101 - ... basal cell - basal cell carcinoma - basal cell nevus syndrome - basophil - batimastat - BAY 12-9566 - BAY 43-9006 - BAY 56-3722 ...
Although cholangiocarcinoma is known to have the histological and molecular features of an adenocarcinoma of epithelial cells ... a majority of people undergo exploratory surgery unless there is already a clear indication that the tumor is inoperable.[12] ... The disease is confirmed by examination of cells from the tumor under a microscope.[4] It is typically an adenocarcinoma (a ... Micrograph of an intrahepatic cholangiocarcinoma (right of image) adjacent to normal liver cells (left of image). H&E stain. ...
... Thouraya Achach,1 Soumaya Rammeh,1 Amel Trabelsi,1 Rached ... Sara C. Shalin, Andrea L. Haws, Dornechia G. Carter, and Neda Zarrin-Khameh, "Clear cell adenocarcinoma arising from ... Harutake Sawazaki, Hirofumi Goto, Noriyasu Takao, Yoji Taki, and Hideo Takeuchi, "Clear Cell Adenocarcinoma Arising From ... "Clear cell adenocarcinoma arising from abdominal wall endometriosis," Cirugía y Cirujanos (English Edition), 2016. View at ...
Clear-cell adenocarcinoma of the vagina Clear-cell ovarian carcinoma Uterine clear-cell carcinoma Clear-cell adenocarcinoma of ... which is a type of Clear-cell carcinoma of the lung) See also: Clear-cell squamous cell carcinoma of the lung Clear-cell ... Clear-cell adenocarcinoma is a type of adenocarcinoma that shows clear cells. Types include: ...
Adenocarcinoma. Adenocarcinoma, Clear Cell. Cystadenoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. ... Clear cell carcinoma. Paclitaxel-platinum. Chemotherapy. response to chemotherapy. survival of clear cell ovarian carcinoma. ... Clear cell carcinoma comprises 5-10% of surface epithelial ovarian cancers, and about 30-40% of the patients with clear cell ... Ovarian Clear Cell Adenocarcinoma Review (OCCA). The safety and scientific validity of this study is the responsibility of the ...
Clear-cell adenocarcinoma (CCA) of the vagina (or cervix) is a rare Adenocarcinoma (cancer) often linked to diethylstilbestrol ... Clear cell adenocarcinoma entry in the public domain NCI Dictionary of Cancer Terms DES Action USA [1] national consumer ... "Higher incidence of clear cell adenocarcinoma of the cervix and vagina among women born between 1947 and 1971 in the United ... DES Daughters should have a special pap/pelvic exam every year because of their lifelong risk for clear-cell adenocarcinoma. ...
"Clear cell adenocarcinoma of the colon arising in endometriosis: a rare variant of primary colonic adenocarcinoma," Journal of ... C. A. Rubio, "Clear cell adenocarcinoma of the colon," Journal of Clinical Pathology, vol. 48, no. 12, pp. 1142-1144, 1995. ... Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature. Christian Daniel Barrera-Maldonado,1 ... K. Soga, H. Konishi, N. Tatsumi et al., "Clear cell adenocarcinoma of the colon: a case report and review of literature," World ...
Every Step of the Way, a Wide Range of Cell Health Products. Maintaining healthy cells is the key to experimental success and ... weve highlighted the technologies and products within cell biology that are critical to maintaining optimal cell health. No ... To give you confidence in the health of your cells every step of the way, ... matter how you are using your cells, you can count on these products to help keep them healthy. ...
Clear Cell including probable outcomes, duration, recurrence, complications, deaths, and survival rates. ... Symptoms: Adenocarcinoma, Clear Cell *Complications: Adenocarcinoma, Clear Cell *Treatments: Adenocarcinoma, Clear Cell About ... See also complications of Adenocarcinoma, Clear Cell. Adenocarcinoma, Clear Cell: Research More. *Adenocarcinoma, Clear Cell: ... Clear Cell usually refers to the likely outcome of Adenocarcinoma, Clear Cell. The prognosis of Adenocarcinoma, Clear Cell may ...
Associations diethylstilbestrol exposure References Ahrens WA, Barron-Rodriguez LP, McKee M, Rivkees S, Reyes-Mugica M. Clear ... Ahrens WA, Barron-Rodriguez LP, McKee M, Rivkees S, Reyes-Mugica M. Clear Cell Adenocarcinoma of the Cervix in a Child without ... Home , E. Pathology by systems , Reproductive system , Female genital system , Uterus , Uterine cervix , cervical clear cell ...
Non-clear-cell adenocarcinoma Vagina MeSH Terms expand_less. expand_more. Adenocarcinoma Aged Basophils Cellular Structures ... The adenocarcinoma did not appear to be associated with vaginal adenosis. It lacked clear cell component and interestingly ... A case of primary non-clear-cell adenocarcinoma of the vagina is reported occurring in a 65-year-old woman without exposure to ... Primary Non-clear-cell Adenocarcinoma of the Vagina: Report of a Case. ...
A Case of Clear Cell Adenocarcinoma Arising in the Endometriosis of the Rectum Treated by Laparoscopic Surgery. Yu Okazawa, ... We report a very rare case of clear cell adenocarcinoma arising from endometriosis of the rectum. An 83-year-old woman was ... Histopathological examination revealed an adenocarcinoma, similar to clear cell carcinoma of the ovary, invading the subserosa ... Endometrioid adenocarcinoma arising from ectopic endometriosis is very rare, and was first described by Marx in 1949. Including ...
Urethral cancer is a rare malignancy with urothelial subtype being the most common followed by adenocarcinoma. In women, the ... Clear cell adenocarcinoma of the urethra with inguinal lymph node metastases: A rare case report and review of literature April ... Clear cell variety of adenocarcinoma is a rarer entity which usually has a better prognosis than other variants. Lymph node ... The detailed evaluation revealed clear cell adenocarcinoma of the urethra as the primary with lymph node metastasis. ...
Long-Term Follow-up of Women With DES-Related Vaginal and Cervical Clear Cell Adenocarcinoma. By Matthew Stenger and compiled ... Patients with clear cell adenocarcinoma had greater mortality risk across their life span. Compared with the general U.S. ... women with DES-related clear cell adenocarcinoma are aging into their 50s and 60s, but the effect of this condition across ... risk of death among women with DES-related clear cell adenocarcinoma was 27 times higher for women aged between 10 and 34 years ...
... clear cell adenocarcinoma of the ovaryLow expression of S100P is associated with poor prognosis in patients with clear cell ... adenocarcinoma of the ovary. 卵巣明細胞腺癌においてS100P発現低
Ovarian clear cell adenocarcinoma (OCCA) is recognized as a distinct histological type of cancer, and its frequency among ... Clear cell carcinoma has an expression pattern of cell cycle regulatory molecules that is unique among ovarian adenocarcinomas ... Promoter Methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma. Zeitschrift:. Molecular ... Kennedy AW, Biscotti CV, Hart WR, Webster KD: Ovarian clear cell adenocarcinoma. Gynecol Oncol. 1989, 32: 342-349. 10.1016/0090 ...
Mixed Serous and Clear Cell Adenocarcinoma of the Ovary Presenting with Symptomatic Hypercalcemia: A Case Report and Clinical ... Mixed serous and clear cell adenocarcinoma of the ovary presenting with symptomatic hypercalcemia: A case report and clinical ... 4. Lewin S, Dezube D, Guddati A, Mittal K, Muggia F, Klein P. Paraneoplastic hypercalcemia in clear cell ovarian adenocarcinoma ... The pathologic findings were confirmed by 3 different pathologists as serous and clear cell, lacking features of small cell ...
Cancer: Clear Cell Adenocarcinoma (CCA). September 20, 2007. By Diseases & Conditions Clear cell adenocarcinoma (CCA) is a rare ... form of vaginal and cervical cancer in which the inside of the tumorous cells appear clear when viewed through a microscope. It ...
What is clear cell adenocarcinoma? Meaning of clear cell adenocarcinoma medical term. What does clear cell adenocarcinoma mean? ... Looking for online definition of clear cell adenocarcinoma in the Medical Dictionary? clear cell adenocarcinoma explanation ... clear cell prostatic adenocarcinoma, and metastatic clear cell renal cell carcinoma.. Adenocarcinoma of the urinary bladder ... Clear cell adenocarcinoma (CCA) usually arises from the female genital tract.. Clear cell adenocarcinoma of the urinary bladder ...
Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
... with multifocal bilateral choroid metastatic lesions that were found to originate from a primary clear cell adenocarcinoma of ... The aim of the present report was to draw the attention of oncologists to the importance of prompt diagnosis of primary clear ... cell adenocarcinoma of the lung, which allows early initiation of treatment to maintain quality of life. A 63-year-old Chinese ... Clear cell adenocarcinoma of the lung with an abundant clear cell component is extremely rare, and the associated biological ...
Unlike squamous cell carcinoma, clear cell adenocarcinoma manifests in patients at a very early age, usually after age 14 years ... Clear Cell Adenocarcinoma Surgery. Therapeutic considerations are very similar to those for patients with squamous cell ... Clear cell adenocarcinoma - Although the etiology is different, the presentation may be similar to that of squamous cell ... Clear cell adenocarcinoma. This is the second most common type of primary vaginal carcinoma, accounting for about 9% of all ...
Tag: Clear Cell Adenocarcinoma. Clear Cell Adenocarcinoma of the Ovary Associated with In Utero DES Exposure. A 45-year-old ... Clear Cell Adenocarcinoma, DES, DES-exposed, NCBI, United StatesLeave a comment on Genital clear cell adenocarcinoma. ... Clear Cell Adenocarcinoma, DES, DES-exposed, Endometriosis, NCBI, Ovarian Cancer2 Comments on Clear Cell Adenocarcinoma of the ... Clear Cell Adenocarcinoma, DES, DES-exposed, NCBILeave a comment on Diethylstilbestrol DES-induced clear cell adenocarcinoma of ...
... vs Physicians Choice Chemotherapy in Recurrent Ovarian Clear Cell Adenocarcinoma (MOCCA)" trial is an open-label study which ... Do clear cell ovarian carcinomas have poorer prognosis compared to other epithelial cell types? A study of 1411 clear cell ... Interestingly, clear cell ovarian cancer shares more similarity in gene expression profiles with clear cell renal cell ... where clear cell cancers constitute up to 25% of diagnosed ovarian cancer.1 2 Histologically, ovarian clear cell carcinoma is ...
Clear Cell Adenocarcinoma (CCA):. Clear Cell Carcinoma: A rare type of tumor of the female genital tract in which the inside of ... the cells look clear when viewed under a microscope.. Adenocarcinoma: A cancer that begins in cells that line certain internal ... Squamous Cells: Flat cells that look like fish scales under a microscope. These cells cover internal and external surfaces of ... Squamous Cell Carcinoma: Cancer that begins in squamous cells, which are thin, flat cells resembling fish scales. Squamous ...
Endometrioid adenocarcinoma no [18] Mesonephric adenocarcinoma [18] Clear cell adenocarcinoma no [16][17][18] ... Micrograph of a small-cell carcinoma showing cells with nuclear moulding, minimal amount of cytoplasm and stippled chromatin. ... Micrograph showing the yolk sac component of a mixed germ cell tumour. H&E stain. ... a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears ...
... but close to zero in clear cell adenocarcinomas.. The median H-score concerning HNF-1b was 250 in clear cell adenocarcinomas, ... Differentiating clear cell adenocarcinoma from serous and endometrioid adenocarcinoma in the ovary ... Differentiating clear cell adenocarcinoma from serous and endometrioid adenocarcinoma in the ovary ... Differentiating clear cell adenocarcinoma from serous and endometrioid adenocarcinoma in the ovary ...
  • The tumor is composed of polygonal, cuboidal to columnar cells with clear cytoplasm arranged in solid nests and tubule-cystic growth patterns. (biomedcentral.com)
  • The cells have clear to foamy eosinophilic cytoplasm and uniform round nuclei with vesicular chromatin and small round nucleoli. (ucdavis.edu)
  • In histopathology, a hobnail cell is a cell with a characteristic appearance, including a bulbous nucleus and nuclear projections into the cytoplasm. (wikipedia.org)
  • Upon microscopic examination, the PNE cells have round, oval, or spindle nuclei with salt-and-pepper chromatin and clear or eosinophilic cytoplasm. (wikipedia.org)
  • The ectodomain is the domain of a membrane protein which is outside the cell, outside the cytoplasm [extracytoplasmic] and exposed to the extracellular space (when not inside the lumen on intracellular vesicles in the secretory or endocytic pathways). (wikipedia.org)
  • however, it is known that MORT is found preferentially in the cell cytoplasm with differential density centrifugation showing that MORT is enriched in the 100,000 g fraction, which contains polysomes, microsomes, endoplasmic reticulum, and the plasma membrane. (wikipedia.org)
  • Since the epidemiologic curve was similar between the two groups, some of the patients with clear-cell adenocarcinoma for whom there was no documentation of DES exposure may have actually been exposed to DES in utero, and thus the true survival difference between women with DES exposure and those with idiopathic clear-cell adenocarcinoma would be larger without potential misclassification. (desdaughter.com)
  • I. To evaluate improvement in progression-free survival for patients treated with anti-programmed cell death 1 (anti-PD1) pembrolizumab in combination with intravenous (IV) bevacizumab and oral metronomic cyclophosphamide as compared to patients treated with other second line chemotherapeutic agents. (clinicaltrials.gov)
  • Lethal protein-protein interactions at the metastatic site aid the survival of adapted cells. (wikipedia.org)
  • CLU promotes cell survival by a number of means, including inhibition of BAX on the mitochondrial membrane, activation of the phosphatidylinositol 3-kinase/protein kinase B pathway, modulation of extracellularular signal-regulated kinase (ERK) 1/2 signaling and matrix metallopeptidase-9 expression, promotion of angiogenesis, and mediation of the nuclear factor kappa B (NF-κB) pathway. (wikipedia.org)
  • Collectively, this type of receptor is known as a dependence receptor because the unbound pathway is usually apoptotic, meaning that cell survival depends on ligand presence. (wikipedia.org)
  • Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. (wikipedia.org)
  • The removal of cells or tissues for examination under a microscope. (cdc.gov)
  • Biopsy The removal of cells or tissues for exam- research findings in a clear and understandable ination under a microscope. (cdc.gov)
  • Other presenting symptoms described have included: flu-like syndrome with cough and fever, FA is an epithelial tumor whose cells and architecture resemble that of fetal lung tissues in the pseudoglandular stage of development (which occurs at about 10-16 weeks gestation in the human), with complex glandular structures and morules with cell nuclei that appear clear due to the accumulation of biotin. (wikipedia.org)
  • Within tissues, IGFBP-3 can bind IGF-1 and IGF-2 released by many cell types, and block their access to the IGF-1 receptor (IGF1R), which is activated by both IGFs. (wikipedia.org)
  • MORT is expressed in all 16 normal human tissues reported in the Illumina body map data, as well as all in vitro cultured, finite lifespan, human cell strains that have been analyzed. (wikipedia.org)
  • A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist involving extraction of sample cells or tissues for examination to determine the presence or extent of a disease. (wikipedia.org)
  • The gene is highly conserved in species, and the protein is widely distributed in many tissues and organs, where it participates in a number of biological processes, including lipid transport, membrane recycling, cell adhesion, programmed cell death, and complement-mediated cell lysis. (wikipedia.org)
  • Together these results suggest that miR-155-5p is expressed in a number of tissues and cell types and, therefore, may play a critical role in a wide variety of biological processes, including hematopoiesis Although very few studies have investigated the expression levels of miR-155-3p, Landgraf et al. (wikipedia.org)
  • However, later on it was found to be expressed in all types of cells including many non-adipose tissues. (wikipedia.org)
  • Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. (wikipedia.org)
  • However, in some of the colonic crypts all of the cells lack MT-COI and appear mostly white, with their main color being the blue-gray staining of the nuclei at the outer walls of the crypts. (wikipedia.org)