Adenocarcinoma, Clear Cell: An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)Inguinal Canal: The tunnel in the lower anterior ABDOMINAL WALL through which the SPERMATIC CORD, in the male; ROUND LIGAMENT, in the female; nerves; and vessels pass. Its internal end is at the deep inguinal ring and its external end is at the superficial inguinal ring.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Urethral Neoplasms: Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Primary urethral carcinomas are rare and typically of squamous cells. Urethral carcinoma is the only urological malignancy that is more common in females than in males.Groin: The external junctural region between the lower part of the abdomen and the thigh.Urinary Retention: Inability to empty the URINARY BLADDER with voiding (URINATION).Vaginal Neoplasms: Tumors or cancer of the VAGINA.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Penile Neoplasms: Cancers or tumors of the PENIS or of its component tissues.Urethra: A tube that transports URINE from the URINARY BLADDER to the outside of the body in both the sexes. It also has a reproductive function in the male by providing a passage for SPERM.Periodic Acid-Schiff Reaction: A histochemical technique for staining carbohydrates. It is based on PERIODIC ACID oxidation of a substance containing adjacent hydroxyl groups. The resulting aldehydes react with Schiff reagent to form a colored product.Cystadenofibroma: Benign or borderline malignant neoplasm of the ovary and surrounding tissues. It is characterized by tumor(s) with cystic glands which are lined by cuboidal EPITHELIAL CELLS with clear cytoplasm, resembling ENDOMETRIUM cells. The glands are separated by fibroblastic STROMAL CELLS.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Diethylstilbestrol: A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)Cystadenocarcinoma, Serous: A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)Carcinoma, Signet Ring Cell: A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Translational Medical Research: The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.Awards and Prizes
(1/413) Increased expression of the RIalpha subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer.

The primary element in the cAMP signal transduction pathway is the cAMP-dependent protein kinase (PKA). Expression of the RIalpha subunit of type I PKA is elevated in a variety of human tumours and cancer cell lines. The purpose of this study was to assess the prognostic importance of RIalpha expression in patients with ovarian cancer. We have evaluated the expression of RIalpha in a panel of human ovarian tumours (n = 40) and five human ovarian cancer cell lines using quantitative reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis. The human ovarian cell lines OAW42 and OTN14 express high endogenous levels of RIalpha mRNA and protein (at significantly higher mRNA levels than high tissue expressors, P < 0.05). The ovarian cell line A2780 expresses low endogenous levels of RIalpha mRNA and protein (also at higher mRNA levels than low tissue expressors, P < 0.05). Quantitative RT-PCR revealed no significant difference in RIalpha mRNA expression between different ovarian histological subtypes in this study. No associations were found between RIalpha mRNA expression and differentiation state. RIalpha mRNA expression was significantly associated with tumour stage (P = 0.0036), and this remained significant in univariate analysis (P = 0.0002). A trend emerged between RIalpha mRNA expression levels and overall survival in univariate analysis (P = 0.051), however, by multivariate analysis, stage remained the major determinant of overall survival (P = 0.0001). This study indicates that in ovarian epithelial tumours high RIalpha mRNA expression is associated with advanced stage disease. RIalpha expression may be of predictive value in ovarian cancer and may be associated with dysfunctional signalling pathways in this cancer type.  (+info)

(2/413) Loss of heterozygosity at 3p14.2 in clear cell renal cell carcinoma is an early event and is highly localized to the FHIT gene locus.

The VHL tumor suppressor gene (TSG) at 3p25-26 is strongly implicated in the pathogenesis of clear cell renal cell carcinoma (cRCC). In addition, 3p14.2 and 3p21 are suspected of harboring additional TSGs in cRCC, with FHIT being a candidate TSG at 3p14.2. We examined 87 microdissected, histologically well-defined cRCCs classified according to tumor-node-metastasis (TNM) stage (stage 1, 23 cases; stage 2, 14 cases; stage 3, 24 cases; stage 4, 26 cases) and Fuhrman grade (grade 1, 24 cases; grade 2, 19 cases; grade 3, 19 cases; grade 4, 8 cases; sarcomatoid cRCC, 17 cases) for loss of heterozygosity (LOH) at 3p14.2 and 3p25-26 using a series of precisely mapped microsatellite probes. We found that LOH at 3p14.2 exceeded LOH at 3p25-26 in frequency (69% versus 48.3%; P < 0.03) and was highly localized to markers within the FHIT gene locus (D3S1300 and D3S4260), with the majority of chromosomal breakpoints also mapping to this region. In addition, 3p14.2 LOH (P < 0.03), but not 3p25-26 LOH (P = nonsignificant), was associated with lower tumor grades (grades 1-3). These findings suggest that 3p14.2 genomic deletions may be among the earliest events in cRCC pathogenesis, preceding genomic deletions at the VHL locus. FHIT, or an as yet undiscovered TSG mapping to the D3S4103-D3S4260 interval, could be the molecular target of the 3p14.2 deletions.  (+info)

(3/413) Prognostic value of nuclear morphometry in patients with TNM stage T1 ovarian clear cell adenocarcinoma.

In 40 patients with TNM stage T1 ovarian clear cell adenocarcinoma, we used nuclear morphometry to study the relations among morphometric variables, clinical prognostic factors and outcome. The presence of one or more giant nuclear cells was positively associated with death (OR = 10.6, P = 0.02) and tended to be associated with disease recurrence (OR = 5.1, P = 0.07). Nuclear irregularity (expressed in terms of the nuclear roundness factor) was positively associated with both death (OR = 8.6, P = 0.02) and disease recurrence (OR = 8.2, P = 0.02). A combination of giant nuclear cell presence or nuclear irregularity proved to be a useful prognostic indicator, with a sensitivity and specificity of 83% and 71% in the prediction of death, and 75% and 71% in the prediction of disease recurrence. Patients' age and substage were of no prognostic value. We conclude that the nuclear morphometric characteristics, especially the presence of giant nuclear cells and nuclear irregularity, may be useful in predicting outcome in patients with early stage ovarian clear cell adenocarcinoma.  (+info)

(4/413) Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma.

The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in patients with VHL disease and in the majority of patients with sporadic clear cell renal carcinoma (RCC). Overexpression of transforming growth factor (TGF) beta1 has been observed in patients with several cancers, including RCCs, with serum and urine levels correlating inversely with prognosis. We have demonstrated that the VHL tumor suppressor gene product represses TGF-beta1 mRNA and protein levels (approximately 3-4-fold) in 786-O RCC cells by decreasing the TGF-beta1 mRNA half-life. Exogenously added TGF-beta1 did not suppress the growth of 786-O cells in vitro, nor did the addition of neutralizing antibody (Ab) against TGF-beta have any effect. Indeed, 786-O cells were found to express no TGF-beta type II receptor protein, thus allowing them to escape from the negative growth control of TGF-beta1. In contrast to the in vitro data, neutralizing Ab to TGF-beta inhibited tumorigenesis and, in some cases, regressed established 786-O tumors in athymic mice. Immunohistochemistry for von Willebrand's factor revealed a 3-4-fold lower tumor microvessel count in the mice treated with TGF-beta Ab compared to controls, suggesting that the Ab was inhibiting angiogenesis. Our findings indicate that TGF-beta1 is a novel target for the VHL tumor suppressor and that antagonizing its paracrine action may provide novel avenues for treatment of RCCs as well as other tumors that secrete TGF-beta1.  (+info)

(5/413) Clear cell carcinoma arising in a Cesarean section scar endometriosis: a case report.

Endometriosis of a surgical scar is rare and occurs mainly when a hysterectomy or Cesarean section was performed. We describe a 54-year-old woman with a large suprapubic mass as a definite case of a endomerioid carcinoma developing within the scar endometriosis following Cesarean section. Scar endometriosis, as well as endometriosis at other sites, can turn malignant. Endometrioid carcinoma is the most common histological pattern of malignant tumor arising in endometriosis. But clear cell carcinoma is very unusual. A case of primary clear cell carcinoma in endometriosis of a Cesarean section scar is described. To the best of our knowledge, this is the first documented case of endomerioid carcinoma developing within the scar endometriosis in Korea.  (+info)

(6/413) Overexpression of H-Ryk in mouse fibroblasts confers transforming ability in vitro and in vivo: correlation with up-regulation in epithelial ovarian cancer.

Abnormalities in the function of receptor tyrosine kinases (RTKs) have been demonstrated to be important in the pathogenesis of cancer. H-Ryk, a new member of the RTK family, is an unusual RTK in that it is catalytically inactive because of amino acid substitutions of conserved residues in the catalytic domain. We show by immunohistochemistry that it is expressed in the epithelium, stroma, and blood vessels of normal tissues. Evaluation of a panel of 33 primary ovarian tumors (2 benign, 8 borderline, and 23 malignant) was performed. H-Ryk was overexpressed in borderline and malignant ovarian tumors. In serous and clear cell subtypes, there was increased expression in the epithelium, stroma, and blood vessels. Consistent with this observation, overexpression of H-Ryk in the mouse fibroblast cell line NIH3T3 induces anchorage-independent growth and tumorigenicity in nude mice. This implies that overexpression of the receptor can be transforming and may therefore be significant in the pathogenesis of ovarian cancer.  (+info)

(7/413) Determination of telomerase activity for differential analysis of multifocal renal cell carcinomas.

Secondary tumors are found in approximately 12 to 22% of all renal cell carcinoma, and their origin is currently unknown. To determine their potential for malignancy, we examined the telomerase activity of primary tumors and secondary lesions, and found that 86% of the lesions had an identical telomerase status as the related primary tumors, and thus probably share their malignancy potential.  (+info)

(8/413) Hormone replacement therapy and risk of epithelial ovarian cancer.

It has been suggested that oestrogen replacement therapy is associated with risk of epithelial ovarian cancer of the endometrioid type. Using data from an Australian population-based case-control study, the relation between unopposed oestrogen replacement therapy and epithelial ovarian cancer, both overall and according to histological type, was examined. A total of 793 eligible incident cases of epithelial ovarian cancer diagnosed from 1990 to 1993 among women living in Queensland, New South Wales and Victoria were identified. These were compared with 855 eligible female controls selected at random from the electoral roll, stratified by age and geographic region. Trained interviewers administered standard questionnaires to obtain detailed reproductive and contraceptive histories, as well as details about hormone replacement therapy and pelvic operations. No clear associations were observed between use of hormone replacement therapy overall and risk of ovarian cancer. Unopposed oestrogen replacement therapy was, however, associated with a significant increase in risk of endometrioid or clear cell epithelial ovarian tumours (odds ratio (OR) 2.56; 95% confidence interval (CI) 1.32-4.94). In addition, the risk associated with oestrogen replacement therapy was much larger in women with an intact genital tract (OR 3.00; 95% CI 1.54-5.85) than in those with a history of either hysterectomy or tubal ligation. Post-menopausal oestrogen replacement therapy may, therefore, be a risk factor associated with endometrioid and clear cell tumours in particular. Additionally, the risk may be increased predominantly in women with an intact genital tract. These associations could reflect a possible role of endometriosis in the development of endometrioid or clear cell ovarian tumours.  (+info)

*  Adenocarcinoma
... which describes a cancer that has developed in the epithelial cells. Clear-cell adenocarcinoma From adeno-, "gland" and karkin( ... By staining the cells from a biopsy, a pathologist can determine whether the tumor is an adenocarcinoma or some other type of ... prostate cancer is nearly always adenocarcinoma cervical cancer: most is squamous cell cancer, but 10-15% of cervical cancers ... This cancer usually is seen peripherally in the lungs, as opposed to small cell lung cancer and squamous cell lung cancer, ...
*  Diethylstilbestrol
Subsequent studies have shown an approximate 40-fold increased risk of vaginal/cervical clear cell adenocarcinoma in women ... clear cell adenocarcinoma) of the vagina and/or cervix. DES Diethylstilbestrol Provides resources and social media links for ... who had been diagnosed with vaginal clear cell adenocarcinoma had been exposed prenatally to DES. ... In 1971, DES was shown to cause clear cell carcinoma, a rare vaginal tumor, in girls and women who had been exposed to this ...
*  Clear-cell adenocarcinoma
... of the vagina Clear-cell ovarian carcinoma Uterine clear-cell carcinoma Clear-cell adenocarcinoma of ... which is a type of Clear-cell carcinoma of the lung) See also: Clear-cell squamous cell carcinoma of the lung Clear-cell ... Clear-cell adenocarcinoma is a type of adenocarcinoma that shows clear cells. Types include: ...
*  Clear-cell adenocarcinoma of the vagina
Clear-cell adenocarcinoma (CCA) of the vagina (or cervix) is a rare Adenocarcinoma (cancer) often linked to diethylstilbestrol ... Clear cell adenocarcinoma entry in the public domain NCI Dictionary of Cancer Terms DES Action USA [1] national consumer ... "Higher incidence of clear cell adenocarcinoma of the cervix and vagina among women born between 1947 and 1971 in the United ... DES Daughters should have a special pap/pelvic exam every year because of their lifelong risk for clear-cell adenocarcinoma. ...
*  Cervix
... cancers such as clear cell adenocarcinomas; cervical ridges and hoods; and development of a cockscomb cervix appearance. ... while the ectocervix is covered with multiple layers of cells topped with flat cells. The two types of epithelia meet the ... The cervical canal is a passage through which sperm must travel to fertilize an egg cell after sexual intercourse. Several ... Cervical ectropion refers to the horizontal overgrowth of the endocervical columnar lining in a one-cell-thick layer over the ...
*  Vaginal adenosis
Association with clear cell adenocarcinoma in diethylstilbestrol-exposed offspring". Cancer. 54 (5): 869-875. doi:10.1002/1097- ... It is sometimes considered a precancerous lesion, given clear-cell adenocarcinoma patients present these lesions in close ... "Adenocarcinoma of the vagina in adolescence.A report of 7 cases including 6 clear-cell carcinomas (so-called mesonephromas)". ... Relationship to genital tract clear cell adenocarcinoma and vaginal adenosis in daughters". American Journal of Obstetrics and ...
*  Fetal adenocarcinoma
August 2006). "[Clear cell adenocarcinoma with acomponent of well-differentiated fetal adenocareinoma; report of a case]". ... Fetal adenocarcinoma (FA) of the lung is a rare subtype of pulmonary adenocarcinoma that exhibits tissue architecture and cell ... There also seems to be an association with clear cell lung cancer variants. A case of combined small cell lung carcinoma ... Synonyms for FA include well differentiated fetal adenocarcinoma, high-grade fetal adenocarcinoma, pulmonary adenocarcinoma of ...
*  Clear cell carcinoma
... clear cell endometrial cancer Clear-cell ovarian carcinoma clear-cell adenocarcinoma, synonym or major subtype clear-cell ... Also called clear cell adenocarcinoma and mesonephroma." Examples : Clear cell renal cell carcinoma ~ clear cell kidney cancer ... A Clear-cell carcinoma is a carcinoma (i.e. not a sarcoma) showing clear cells. "A rare type of tumor, usually of the female ... in which the insides of the cells look clear when viewed under a microscope. ...
*  Vaginal cancer
Adenocarcinoma is more likely to spread to the lungs and lymph nodes. Clear cell adenocarcinoma occurs in a small percentage of ... squamous-cell carcinoma and adenocarcinoma. Vaginal squamous-cell carcinoma arises from the squamous cells (epithelium) that ... Approximately one in 1,000 (0.1%) DES Daughters will be diagnosed with clear cell adenocarcinoma. The risk is virtually non- ... Vaginal adenocarcinoma arises from the glandular (secretory) cells in the lining of the vagina that produce some vaginal fluids ...
*  ABCF2
"Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses ... expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of ... "Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells ...
*  GPX3
2008). "Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma". ... Cell. Biol. 29 (1): 20-30. doi:10.1128/MCB.00544-08. PMC 2612482 . PMID 18936159. Wang Y, Fu W, Xie F, et al. (2010). "Common ... Cell Genet. 66 (2): 96-8. doi:10.1159/000133675. PMID 8287691. Guey LT, García-Closas M, Murta-Nascimento C, et al. (2010). " ... 2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell ...
*  Hobnail cell
Hobnail cells are found in clear cell ovarian adenocarcinoma, collecting duct carcinoma, and in end-stage cirrhosis. Kumar, ... In histopathology, a hobnail cell is a cell with a characteristic appearance, including a bulbous nucleus and nuclear ...
*  Class III β-tubulin
... of class III beta-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma". Clinical ... However, there are also data in clear cell carcinoma, melanoma and breast cancer showing favorable prognosis. Class III β- ... Cell. 140 (1): 74-87. doi:10.1016/j.cell.2009.12.011. PMC 3164117 . PMID 20074521. André N, Braguer D, Brasseur G, Gonçalves A ... Sieber-Blum M, Schnell L, Grim M, Hu YF, Schneider R, Schwab ME (2006). "Characterization of epidermal neural crest stem cell ( ...
*  Mixed Müllerian tumor
On histology, the tumors consist of adenocarcinoma (endometrioid, serous or clear cell) mixed with the malignant mesenchymal ( ... or that the tumor is the result of a stem cell that differentiates into different cell types (the "combination" theory). " ... first from a stem cell into a population of cells, that then differentiates into epithelial and stromal components. There is ... As with endometrial carcinomas, the prognosis is influenced by the grade and type of the adenocarcinoma, being poorest with ...
*  Birth defect
... a synthetic estrogen used from the 1940s to 1971 when the prenatal exposition has been linked to the clear-cell adenocarcinoma ... Male germ cells mutate at a much faster rate than female germ cells, and as the father ages, the DNA of the germ cells mutates ... This is because, as humans age, male germ cells acquire mutations at a much faster rate than female germ cells. Around a 5% ... Cigarette smoke acts as a chemical mutagen on germ cell DNA. The germ cells suffer oxidative damage, and the effects can be ...
*  Kidney cancer
Most cancers in the renal tubule are renal cell carcinoma and clear cell adenocarcinoma. Most cancers in the renal pelvis are ... These include: Clear cell adenocarcinoma Transitional cell carcinoma Inverted papilloma Renal lymphoma Teratoma Carcinosarcoma ... Squamous cell carcinoma Juxtaglomerular cell tumor (reninoma) Angiomyolipoma Bellini duct carcinoma Clear-cell sarcoma of the ... In the second line setting, nivolumab demonstrated an overall survival advantage in advanced clear renal cell carcinoma over ...
*  Von Hippel-Lindau tumor suppressor
... clear cell adenocarcinomas. The protein encoded by this gene is a component of the protein complex that includes elongin B, ... It is clear that VHL and HIF interact closely. Firstly, all renal cell carcinoma mutations in VHL that have been tested affect ... Kaelin WG (January 2007). "The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma". Clinical Cancer ... Kaelin WG (January 2007). "The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma". Clinical Cancer ...
*  Sybil Shainwald
Bichler, who at 17 had developed clear cell adenocarcinoma of the cervix and vagina requiring the removal of her reproductive ...
*  Hobnail (disambiguation)
... is medical jargon for cirrhosis of the liver Cellular morphology pathognomonic for clear cell adenocarcinoma of the ovary. ...
*  Fetal origins hypothesis
... was found to be causing an incredibly rare vaginal cancer known as clear-cell adenocarcinoma in young girls when the cancer was ...
*  Index of oncology articles
... clear cell adenocarcinoma - clear-cell sarcoma - clear cell sarcoma of the kidney - clinical breast exam - clinical resistance ... cell - cell differentiation - cell motility - cell proliferation - cell respiration - cell adhesion - cellular adoptive ... systemic therapy T cell - T-3 - T-cell depletion - T-cell lymphoma - T138067 - T4N5 liposomal lotion - T900607 - TAC-101 - ... basal cell - basal cell carcinoma - basal cell nevus syndrome - basophil - batimastat - BAY 12-9566 - BAY 43-9006 - BAY 56-3722 ...
*  Ovarian cancer
Clear-cell adenocarcinomas are histopathologically similar to other clear cell carcinomas, with clear cells and hobnail cells. ... They are typically early-stage and therefore curable by surgery, but advanced clear-cell adenocarcinomas (approximately 20%) ... Usually, when cells grow old or get damaged, they die, and new cells take their place. Cancer starts when new cells form ... Germ cell tumors of the ovary develop from the ovarian germ cells. Germ cell tumor accounts for about 30% of ovarian tumors, ...
*  Salivary gland tumour
... carcinoma Adenoid cystic carcinoma Polymorphous low-grade adenocarcinoma Epithelial-myoepithelial carcinoma Clear cell ... not otherwise specified Basal cell adenocarcinoma Sebaceous carcinoma Sebaceous lymphadenocarcinoma Cystadenocarcinoma Low- ... MRI Biopsy: The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of ... tissue tumors Hemangioma Hematolymphoid tumors Hodgkin lymphoma Diffuse large B-cell lymphoma Extranodal marginal zone B cell ...
*  Duocarmycin
... including clear cell Caki-1 carcinoma, colon CX-1 adenocarcinoma, lung LX-1 tumor, ovarian 2780 carcinoma, and prostatic DU-145 ... balancing the effect of potent cell-killing agents on tumor cells versus healthy cells. The synthetic analogs of duocarmycins ... M cell cycle arrest and eventual senescence without significant apoptotic cell death. However, in cells lacking p21, bizelesin ... Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without ...
*  Clear-cell tumor
... clear-cell sarcoma, including clear-cell sarcoma of the kidney clear-cell carcinoma, all/mostly clear-cell adenocarcinoma. ... Clear-cell tumor (any with Clear cells) can refer to: ...
*  Cervical cancer
... adenosquamous carcinoma small cell carcinoma neuroendocrine tumour glassy cell carcinoma villoglandular adenocarcinoma ... If a cone biopsy does not produce clear margins (findings on biopsy showing that the tumor is surrounded by cancer free tissue ... About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. ... squamous cell carcinoma (about 80-85%) adenocarcinoma (about 15% of cervical cancers in the UK) ...
JAIRO | Low expression of S100P is associated with poor prognosis in patients with clear cell adenocarcinoma of the ovary  JAIRO | Low expression of S100P is associated with poor prognosis in patients with clear cell adenocarcinoma of the ovary
... clear cell adenocarcinoma of the ovaryLow expression of S100P is associated with poor prognosis in patients with clear cell ... adenocarcinoma of the ovary. 卵巣明細胞腺癌においてS100P発現低
more infohttp://jairo.nii.ac.jp/0013/00028986/en
Vaginal Cancer Symptoms & Treatment | Cleveland Clinic  Vaginal Cancer Symptoms & Treatment | Cleveland Clinic
Clear cell adenocarcinoma is the exception, often affecting younger women who were exposed to DES in their mother's womb. ... Women whose mothers took DES - known as DES daughters - develop clear-cell adenocarcinoma of the vagina or cervix more often ... The vagina is lined by a layer of flat cells called squamous cells. This layer of cells is also called epithelium because it is ... Adenocarcinoma: This type of cancer begins in gland cells in the vagina. It accounts for about 15 percent of vaginal cancer, ...
more infohttps://my.clevelandclinic.org/health/diseases/15579-vaginal-cancer
Risk factors for vaginal cancer - Canadian Cancer Society  Risk factors for vaginal cancer - Canadian Cancer Society
Women whose mothers took DES during their pregnancy have a higher than average risk of developing clear cell adenocarcinoma of ... When the immune system is weakened, there is a greater chance that precancerous changes to cells in the vagina can develop into ... Only some of them cause abnormal changes to cells that may turn into cancer. ...
more infohttp://www.cancer.ca/en/cancer-information/cancer-type/vaginal/risks/?region=bc
Risk factors for vaginal cancer - Canadian Cancer Society  Risk factors for vaginal cancer - Canadian Cancer Society
Women whose mothers took DES during their pregnancy have a higher than average risk of developing clear cell adenocarcinoma of ... When the immune system is weakened, there is a greater chance that precancerous changes to cells in the vagina can develop into ... Only some of them cause abnormal changes to cells that may turn into cancer. ...
more infohttp://www.cancer.ca/en/cancer-information/cancer-type/vaginal/risks/?region=sk
RETRACTED ARTICLE: Increased frequency and nocturia in a middle aged male may not always be due to Benign Prostatic Hypertrophy...  RETRACTED ARTICLE: Increased frequency and nocturia in a middle aged male may not always be due to Benign Prostatic Hypertrophy...
The second is that diffuse signet ring cell adenocarcinoma derives from isolated signet ring cells that exist scattered in ... cells containing nuclei compressed to one edge of the cell by large amounts of cytoplasmic mucin appearing as a single clear ... Primary signet-ring cell carcinoma (PSRCC) is a rare variation of adenocarcinoma of the urinary bladder. English literature ... Marino G, Motta E, Mosso L, Bocca C, Ravarino N, Torchio B: Primary signet ring cell adenocarcinoma of the bladder. Minerva ...
more infohttps://casesjournal.biomedcentral.com/articles/10.1186/1757-1626-2-168
Clear-cell adenocarcinoma - Wikipedia  Clear-cell adenocarcinoma - Wikipedia
Clear-cell adenocarcinoma of the vagina Clear-cell ovarian carcinoma Uterine clear-cell carcinoma Clear-cell adenocarcinoma of ... which is a type of Clear-cell carcinoma of the lung) See also: Clear-cell squamous cell carcinoma of the lung Clear-cell ... Clear-cell adenocarcinoma is a type of adenocarcinoma that shows clear cells. Types include: ...
more infohttps://en.wikipedia.org/wiki/Clear-cell_adenocarcinoma
Clear Cell Adenocarcinoma Arising from Abdominal Wall Endometriosis  Clear Cell Adenocarcinoma Arising from Abdominal Wall Endometriosis
... Thouraya Achach,1 Soumaya Rammeh,1 Amel Trabelsi,1 Rached ... Sara C. Shalin, Andrea L. Haws, Dornechia G. Carter, and Neda Zarrin-Khameh, "Clear cell adenocarcinoma arising from ... Harutake Sawazaki, Hirofumi Goto, Noriyasu Takao, Yoji Taki, and Hideo Takeuchi, "Clear Cell Adenocarcinoma Arising From ... "Clear cell adenocarcinoma arising from abdominal wall endometriosis," Cirugía y Cirujanos (English Edition), 2016. View at ...
more infohttps://www.hindawi.com/journals/jo/2008/478325/citations/
Clear-cell adenocarcinoma of the vagina - Wikipedia  Clear-cell adenocarcinoma of the vagina - Wikipedia
Clear-cell adenocarcinoma (CCA) of the vagina (or cervix) is a rare Adenocarcinoma (cancer) often linked to diethylstilbestrol ... Clear cell adenocarcinoma entry in the public domain NCI Dictionary of Cancer Terms DES Action USA [1] national consumer ... "Higher incidence of clear cell adenocarcinoma of the cervix and vagina among women born between 1947 and 1971 in the United ... DES Daughters should have a special pap/pelvic exam every year because of their lifelong risk for clear-cell adenocarcinoma. ...
more infohttps://en.wikipedia.org/wiki/Clear-cell_adenocarcinoma_of_the_vagina
Ovarian Clear Cell Adenocarcinoma Review - Full Text View - ClinicalTrials.gov  Ovarian Clear Cell Adenocarcinoma Review - Full Text View - ClinicalTrials.gov
Adenocarcinoma. Adenocarcinoma, Clear Cell. Cystadenoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. ... Clear cell carcinoma. Paclitaxel-platinum. Chemotherapy. response to chemotherapy. survival of clear cell ovarian carcinoma. ... Clear cell carcinoma comprises 5-10% of surface epithelial ovarian cancers, and about 30-40% of the patients with clear cell ... Ovarian Clear Cell Adenocarcinoma Review (OCCA). The safety and scientific validity of this study is the responsibility of the ...
more infohttps://clinicaltrials.gov/show/NCT02129036
Prognosis of Adenocarcinoma, Clear Cell - RightDiagnosis.com  Prognosis of Adenocarcinoma, Clear Cell - RightDiagnosis.com
Clear Cell including probable outcomes, duration, recurrence, complications, deaths, and survival rates. ... Symptoms: Adenocarcinoma, Clear Cell *Complications: Adenocarcinoma, Clear Cell *Treatments: Adenocarcinoma, Clear Cell About ... See also complications of Adenocarcinoma, Clear Cell. Adenocarcinoma, Clear Cell: Research More. *Adenocarcinoma, Clear Cell: ... Clear Cell usually refers to the likely outcome of Adenocarcinoma, Clear Cell. The prognosis of Adenocarcinoma, Clear Cell may ...
more infohttps://www.rightdiagnosis.com/a/adenocarcinoma_clear_cell/prognosis.htm
es-2 ovarian clear cell adenocarcinoma Cells | Thermo Fisher Scientific - JP  es-2 ovarian clear cell adenocarcinoma Cells | Thermo Fisher Scientific - JP
Every Step of the Way, a Wide Range of Cell Health Products. Maintaining healthy cells is the key to experimental success and ... we've highlighted the technologies and products within cell biology that are critical to maintaining optimal cell health. No ... To give you confidence in the health of your cells every step of the way, ... matter how you are using your cells, you can count on these products to help keep them healthy. ...
more infohttps://www.thermofisher.com/jp/en/home/technical-resources/cell-lines/e/cell-lines-detail-457.html
Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature  Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature
"Clear cell adenocarcinoma of the colon arising in endometriosis: a rare variant of primary colonic adenocarcinoma," Journal of ... C. A. Rubio, "Clear cell adenocarcinoma of the colon," Journal of Clinical Pathology, vol. 48, no. 12, pp. 1142-1144, 1995. ... Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature. Christian Daniel Barrera-Maldonado,1 ... K. Soga, H. Konishi, N. Tatsumi et al., "Clear cell adenocarcinoma of the colon: a case report and review of literature," World ...
more infohttps://www.hindawi.com/journals/crionm/2014/905478/ref/
cervical clear cell adenocarcinoma - Humpath.com - Human pathology  cervical clear cell adenocarcinoma - Humpath.com - Human pathology
Associations diethylstilbestrol exposure References Ahrens WA, Barron-Rodriguez LP, McKee M, Rivkees S, Reyes-Mugica M. Clear ... Ahrens WA, Barron-Rodriguez LP, McKee M, Rivkees S, Reyes-Mugica M. Clear Cell Adenocarcinoma of the Cervix in a Child without ... Home , E. Pathology by systems , Reproductive system , Female genital system , Uterus , Uterine cervix , cervical clear cell ...
more infohttp://humpath.com/spip.php?article7889
Long Term Follow up of DES Related Vaginal and Cervical Clear Cell Adenocarcinoma - The ASCO Post  Long Term Follow up of DES Related Vaginal and Cervical Clear Cell Adenocarcinoma - The ASCO Post
Long-Term Follow-up of Women With DES-Related Vaginal and Cervical Clear Cell Adenocarcinoma. By Matthew Stenger and compiled ... Patients with clear cell adenocarcinoma had greater mortality risk across their life span. Compared with the general U.S. ... women with DES-related clear cell adenocarcinoma are aging into their 50s and 60s, but the effect of this condition across ... risk of death among women with DES-related clear cell adenocarcinoma was 27 times higher for women aged between 10 and 34 years ...
more infohttps://www.ascopost.com/issues/july-25-2018/long-term-follow-up-of-des-related-vaginal-and-cervical-clear-cell-adenocarcinoma/
A Case of Clear Cell Adenocarcinoma Arising in the Endometriosis of the Rectum Treated by Laparoscopic Surgery - SAGES Abstract...  A Case of Clear Cell Adenocarcinoma Arising in the Endometriosis of the Rectum Treated by Laparoscopic Surgery - SAGES Abstract...
A Case of Clear Cell Adenocarcinoma Arising in the Endometriosis of the Rectum Treated by Laparoscopic Surgery. Yu Okazawa, ... We report a very rare case of clear cell adenocarcinoma arising from endometriosis of the rectum. An 83-year-old woman was ... Histopathological examination revealed an adenocarcinoma, similar to clear cell carcinoma of the ovary, invading the subserosa ... Endometrioid adenocarcinoma arising from ectopic endometriosis is very rare, and was first described by Marx in 1949. Including ...
more infohttps://www.sages.org/meetings/annual-meeting/abstracts-archive/a-case-of-clear-cell-adenocarcinoma-arising-in-the-endometriosis-of-the-rectum-treated-by-laparoscopic-surgery/
Clear cell adenocarcinoma of the urethra with inguinal lymph node metastases: A rare case report and review of literature  Clear cell adenocarcinoma of the urethra with inguinal lymph node metastases: A rare case report and review of literature
Urethral cancer is a rare malignancy with urothelial subtype being the most common followed by adenocarcinoma. In women, the ... Clear cell adenocarcinoma of the urethra with inguinal lymph node metastases: A rare case report and review of literature April ... Clear cell variety of adenocarcinoma is a rarer entity which usually has a better prognosis than other variants. Lymph node ... The detailed evaluation revealed clear cell adenocarcinoma of the urethra as the primary with lymph node metastasis. ...
more infohttps://www.urotoday.com/recent-abstracts/urologic-oncology/penile-cancer/103717-clear-cell-adenocarcinoma-of-the-urethra-with-inguinal-lymph-node-metastases-a-rare-case-report-and-review-of-literature.html
Promoter Methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma | springermedizin.de  Promoter Methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma | springermedizin.de
Ovarian clear cell adenocarcinoma (OCCA) is recognized as a distinct histological type of cancer, and its frequency among ... Clear cell carcinoma has an expression pattern of cell cycle regulatory molecules that is unique among ovarian adenocarcinomas ... Promoter Methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma. Zeitschrift:. Molecular ... Kennedy AW, Biscotti CV, Hart WR, Webster KD: Ovarian clear cell adenocarcinoma. Gynecol Oncol. 1989, 32: 342-349. 10.1016/0090 ...
more infohttps://www.springermedizin.de/promoter-methylation-status-of-hin-1-associated-with-outcomes-of/9552148
Clear Cell Adenocarcinoma Archives - DiseasesAndConditions.net  Clear Cell Adenocarcinoma Archives - DiseasesAndConditions.net
Cancer: Clear Cell Adenocarcinoma (CCA). September 20, 2007. By Diseases & Conditions Clear cell adenocarcinoma (CCA) is a rare ... form of vaginal and cervical cancer in which the inside of the tumorous cells appear clear when viewed through a microscope. It ...
more infohttps://diseasesandconditions.net/category/diseases/cancer/clear-cell-adenocarcinoma/
Clear cell adenocarcinoma  Clear cell adenocarcinoma
Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
more infohttps://pharos.nih.gov/idg/diseases/DOID:4468
Clear cell adenocarcinoma | definition of clear cell adenocarcinoma by Medical dictionary  Clear cell adenocarcinoma | definition of clear cell adenocarcinoma by Medical dictionary
What is clear cell adenocarcinoma? Meaning of clear cell adenocarcinoma medical term. What does clear cell adenocarcinoma mean? ... Looking for online definition of clear cell adenocarcinoma in the Medical Dictionary? clear cell adenocarcinoma explanation ... clear cell prostatic adenocarcinoma, and metastatic clear cell renal cell carcinoma.. Adenocarcinoma of the urinary bladder ... Clear cell adenocarcinoma (CCA) usually arises from the female genital tract.. Clear cell adenocarcinoma of the urinary bladder ...
more infohttp://medical-dictionary.thefreedictionary.com/clear+cell+adenocarcinoma
Choroid metastases revealing primary clear cell adenocarcinoma of the lung effectively treated with cisplatin and pemetrexed: a...  Choroid metastases revealing primary clear cell adenocarcinoma of the lung effectively treated with cisplatin and pemetrexed: a...
... with multifocal bilateral choroid metastatic lesions that were found to originate from a primary clear cell adenocarcinoma of ... The aim of the present report was to draw the attention of oncologists to the importance of prompt diagnosis of primary clear ... cell adenocarcinoma of the lung, which allows early initiation of treatment to maintain quality of life. A 63-year-old Chinese ... Clear cell adenocarcinoma of the lung with an abundant clear cell component is extremely rare, and the associated biological ...
more infohttps://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-7-267
Follow-up of Patients with Clear-Cell Adenocarcinoma of the Vagina and Cervix - DES Daughter Network  Follow-up of Patients with Clear-Cell Adenocarcinoma of the Vagina and Cervix - DES Daughter Network
Idiopathic clear-cell adenocarcinoma may be more likely to progress quickly or recur earlier, whereas clear-cell adenocarcinoma ... according to time suggests that clear-cell adenocarcinoma associated with DES exposure and idiopathic clear-cell adenocarcinoma ... Follow-up of Patients with Clear-Cell Adenocarcinoma of the Vagina and Cervix. New England Journal of Medicine, May 3, 2018 - ... The risk of death among women with DES-related clear-cell adenocarcinoma was 27 times higher than that in the general U.S. ...
more infohttps://desdaughter.com/2018/05/06/follow-up-of-patients-with-clear-cell-adenocarcinoma-of-the-vagina-and-cervix/?shared=email&msg=fail
Shye - Patient: Vaginal Cancer | Adenocarcinoma | Clear Cell Adenocarcinoma- Currently in active treatment (initial surgery,...  Shye - Patient: Vaginal Cancer | Adenocarcinoma | Clear Cell Adenocarcinoma- Currently in active treatment (initial surgery,...
Clear Cell Adenocarcinoma Patient Info: Currently in active treatment (initial surgery, receiving chemo rounds/radiation), ... Patient: Clear Cell Adenocarcinoma, Vaginal Cancer * Patient Info: Currently in active treatment (initial surgery, receiving ...
more infohttps://www.whatnext.com/users/shye
Hemihypertrophy, Bilateral Wilms-tumor, and Clear-cell Adenocarcinoma of the Uterine Cervix in a Young Girl

 | DIAL.pr - BOREAL  Hemihypertrophy, Bilateral Wilms-tumor, and Clear-cell Adenocarcinoma of the Uterine Cervix in a Young Girl | DIAL.pr - BOREAL
... and Clear-cell Adenocarcinoma of the Uterine Cervix in a Young Girl. In: Medical and Pediatric Oncology, Vol. 21, no. 9, p. 671 ... Hemihypertrophy, Bilateral Wilms-tumor, and Clear-cell Adenocarcinoma of the Uterine Cervix in a Young Girl Primary tabs. * ... Home» Hemihypertrophy, Bilateral Wilms-tumor, and Clear-cell Adenocarcinoma of the Uterine Cervix in a Young Girl ... tumor in both kidneys and clear-cell adenocarcinoma of the uterine cervix with no maternal history of stilbestrol ingestion ...
more infohttps://dial.uclouvain.be/pr/boreal/object/boreal:49459
Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma with fetal gut differentiation: a rare case report and literature...  Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma with fetal gut differentiation: a rare case report and literature...
... especially for clear cell type and in the postmenopausal women. Based on the limited knowledge about AFP-producing clear cell ... Histological examination was clear cell type EOC. Tumor cells revealed strong immunoreactivity for glypican-3 (GPC3) and AFP ... A total of three papers described the AFP-producing clear cell type EOC are available. The overall survival rate of these cases ... Due to rarity, the appropriate chemotherapy regimen and the biological behavior of AFP-producing clear cell type EOC are still ...
more infohttps://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-018-0426-8
  • Patients with clear cell adenocarcinoma had greater mortality risk across their life span. (ascopost.com)
  • The study found that DES-exposed patients with clear-cell adenocarcinoma had ' increased mortality across their life span . (desdaughter.com)
  • A total of 695 patients with clear-cell adenocarcinoma in the Registry for Research on Hormonal Transplacental Carcinogenesis were followed through 2014 (see the Methods section of the Supplementary Appendix , available with the full text of this letter at NEJM.org ). (desdaughter.com)
  • Since the epidemiologic curve was similar between the two groups, some of the patients with clear-cell adenocarcinoma for whom there was no documentation of DES exposure may have actually been exposed to DES in utero, and thus the true survival difference between women with DES exposure and those with idiopathic clear-cell adenocarcinoma would be larger without potential misclassification. (desdaughter.com)
  • It is sometimes considered a precancerous lesion, given clear-cell adenocarcinoma patients present these lesions in close proximity to atypical tuboendometrial glands, and microglandular hyperplasia has been seen to arise from these lesions. (wikipedia.org)
  • Rather, the precursor of peripheral adenocarcinomas has been termed atypical adenomatous hyperplasia (AAH). (wikipedia.org)
  • Microscopically, AAH is a well-demarcated focus of epithelial proliferation, containing cuboidal to low-columnar cells resembling club cells or type II pneumocytes. (wikipedia.org)
  • Adenocarcinomas can arise in many tissues of the body owing to the ubiquitous nature of glands within the body, and, more fundamentally, to the potency of epithelial cells. (wikipedia.org)
  • Within tissues, IGFBP-3 can bind IGF-1 and IGF-2 released by many cell types, and block their access to the IGF-1 receptor (IGF1R), which is activated by both IGFs. (wikipedia.org)
  • While FA can be diagnosed via biopsy, bronchial brushings, and immunocytochemistry, examination of the whole tumor is required to rule out biphasic pulmonary blastoma, a mixed tumor of higher aggressiveness, wherein FA occurs admixed with primitive blastoma cells. (wikipedia.org)
  • To provide a better understanding of clinical and molecular characteristics of the AFP-producing clear cell type EOC, we conducted a systematic literature review. (biomedcentral.com)