A malignant epithelial tumor with a glandular organization.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Tumors or cancer of the LUNG.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Tumors or cancer of the ESOPHAGUS.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
Tumors or cancer of the STOMACH.
That part of the STOMACH close to the opening from ESOPHAGUS into the stomach (cardiac orifice), the ESOPHAGOGASTRIC JUNCTION. The cardia is so named because of its closeness to the HEART. Cardia is characterized by the lack of acid-forming cells (GASTRIC PARIETAL CELLS).
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the COLON.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A cell line derived from cultured tumor cells.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Tumors or cancer of the INTESTINES.
Tumors or cancer of the PROSTATE.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Tumors or cancer of the DUODENUM.
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
Tumors or cancer of the CECUM.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
A condition in which there is a change of one adult cell type to another similar adult cell type.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Tumors or cancer of the RECTUM.
A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).
A benign epithelial tumor with a glandular organization.
The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.
DNA present in neoplastic tissue.
Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Experimental transplantation of neoplasms in laboratory animals for research purposes.
The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Tumors or cancer of the PARANASAL SINUSES.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Surgical removal of the pancreas. (Dorland, 28th ed)
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Tumors or cancer of the UTERINE CERVIX.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Tumors or cancer of the APPENDIX.
Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Tumors or cancer of the gallbladder.
Tumors or cancer of the SIGMOID COLON.
Excision of part (partial) or all (total) of the esophagus. (Dorland, 28th ed)
Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissue. There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Sialylated Lewis blood group carbohydrate antigen found in many adenocarcinomas of the digestive tract, especially pancreatic tumors.
Tumors or cancer of the UTERUS.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Elements of limited time intervals, contributing to particular results or situations.
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Transplantation between animals of different species.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
RNA present in neoplastic tissue.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Antimetabolites that are useful in cancer chemotherapy.
Endoscopic examination, therapy or surgery of the esophagus.
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
A pair of anal glands or sacs, located on either side of the ANUS, that produce and store a dark, foul-smelling fluid in carnivorous animals such as MEPHITIDAE and DOGS. The expelled fluid is used as a defensive repellent (in skunks) or a material to mark territory (in dogs).
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Antibodies produced by a single clone of cells.
Metastases in which the tissue of origin is unknown.
Inhaling and exhaling the smoke of burning TOBACCO.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
Biochemical identification of mutational changes in a nucleotide sequence.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.
Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.
A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Excision of the uterus.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
An embryonic structure originating from the ALLANTOIS. It is a canal connecting the fetal URINARY BLADDER and the UMBILICUS. It is normally converted into a fibrous cord postnatally. When the canal fails to be filled and remains open (patent urachus), urine leaks through the umbilicus.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Tumors or cancer of the LIVER.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.
Neoplasms composed of more than one type of neoplastic tissue.
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
Tumors or cancer of the NOSE.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
Tumors or cancer of the SALIVARY GLANDS.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
Tumors or cancer of the BILE DUCTS.
A BETARETROVIRUS that causes pulmonary adenomatosis in sheep (PULMONARY ADENOMATOSIS, OVINE).
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Tumors or cancer of the DIGESTIVE SYSTEM.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Tumors or cancer of the VAGINA.
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Retrograde flow of duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the STOMACH.

Stimulation of thymidine uptake and cell proliferation in mouse embryo fibroblasts by conditioned medium from mammary cells in culture. (1/18479)

Undialyzed conditioned medium from several cell culture sources did not stimulate thymidine incorporation or cell overgrowth in quiescent, density-inhibited mouse embryo fibroblast cells. However, dialyzed conditioned medium (DCM) from clonal mouse mammary cell lines MCG-V14, MCG-T14, MCG-T10; HeLa cells; primary mouse adenocarcinoma cells; and BALB/c normal mouse mammary epithelial cells promoted growth in quiescent fibroblasts. The amount of growth-promoting activity produced per cell varied from 24% (HeLa) to 213% (MCG-V14) of the activity produced by primary tumor cells. The production of growth-promoting activity was not unique to tumor-derived cells or cells of high tumorigenicity. The amount of growth-promoting activity produced per cell in the active cultures was not correlated with any of the following: tumorigenicity, growth rat, cell density achieved at saturation, cell type, or species of cell origin. It is concluded that transformed and non-transformed cells of diverse origin, cell type, and tumorigenicity can produce growth factors in culture. The growth-promoting potential of the active media from primary tumor cultures accumulated with time of contact with cells and was too great to be accounted for entirely by the removal of low-molecular-weight inhibitors by dialysis. The results are consistent with the hypothesis that conditioned medium from the active cultures contained a dialyzable, growth-promoting activity. Different cell lines exhibited differential sensitivity to tumor cell DCM and fetal bovine serum. Furthermore, quiescent fibroblasts were stimulated by primary tumor cell DCM in the presence of saturating concentrations of fetal bovine serum. These observations support the notion that the active growth-promoting principle in primary tumor cell DCM may not be a serum factor(s).  (+info)

Classification of human colorectal adenocarcinoma cell lines. (2/18479)

Eleven human colorectal adenocarcinoma cell lines established in this laboratory were classified into three groups based on morphological features (light and electron microscopy), modal chromosome number, and ability to synthesize carcinoembryonic antigen (CEA). Group 1 cell lines contained both dedifferentiated and differentiating cells growing in tight clusters or islands of epithelium-like cells; their modal chromosome number was about 47, and they synthesized small to moderate amounts of CEA. Group 2 cell lines were more dedifferentiated, were hyperdiploid, and synthesized small amounts of CEA. Group 3 cell lines were morphologically similar to those of Group 1 by light microscopy. They differed ultrastructurally by containing microvesicular bodies; the modal chromosome number varied from hyperdiploid to hypertriploid or they had bimodal populations of hypodiploid and hypertriploid cells, and they synthesized relatively large amounts of CEA. No correlation could be found between Broder's grade or Duke's classification of the original tumor and modal chromosome number or ability to synthesize CEA. These findings support Nowell's hypothesis that the stem line is different for each solid tumor, which makes it difficult to relate chromosomal changes to the initiation of the neoplastic state.  (+info)

Expression of Bcl-2 protein is decreased in colorectal adenocarcinomas with microsatellite instability. (3/18479)

Bcl-2 is known to inhibit apoptosis and is thought to play a role in colorectal tumour development. Studies of the promoter region of bcl-2 have indicated the presence of a p53 responsive element which downregulates bcl-2 expression. Since p53 is commonly mutated in colorectal cancers, but rarely in those tumours showing microsatellite instability (MSI), the aim of this study was to examine the relationship of bcl-2 protein expression to MSI, as well as to other clinicopathological and molecular variables, in colorectal adenocarcinomas. Expression of bcl-2 was analysed by immunohistochemistry in 71 colorectal cancers which had been previously assigned to three classes depending upon their levels of MSI. MSI-high tumours demonstrated instability in three or more of six microsatellite markers tested, MSI-low tumours in one or two of six, and MSI-null in none of six. Bcl-2 expression in tumours was quantified independently by two pathologists and assigned to one of five categories, with respect to the number of cells which showed positive staining: 0, up to 5%; 1, 6-25%; 2, 26-50%; 3, 51-75%; and 4, > or =76%. Bcl-2 negative tumours were defined as those with a score of 0. Bcl-2 protein expression was tested for association with clinicopathological stage, differentiation level, tumour site, age, sex, survival, evidence of p53 inactivation and MSI level. A significant association was found between bcl-2 expression and patient survival (P = 0.012, Gehan Wilcoxon test). Further, a significant reciprocal relationship was found between bcl-2 expression and the presence of MSI (P = 0.012, Wilcoxon rank sum test). We conclude that bcl-2 expressing colorectal cancers are more likely to be MSI-null, and to be associated with improved patient survival.  (+info)

Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity. (4/18479)

We previously reported that the role of reactive oxygen intermediates (ROIs) in NF-kappaB activation by proinflammatory cytokines was cell specific. However, the sources for ROIs in various cell types are yet to be determined and might include 5-lipoxygenase (5-LOX) and NADPH oxidase. 5-LOX and 5-LOX activating protein (FLAP) are coexpressed in lymphoid cells but not in monocytic or epithelial cells. Stimulation of lymphoid cells with interleukin-1beta (IL-1beta) led to ROI production and NF-kappaB activation, which could both be blocked by antioxidants or FLAP inhibitors, confirming that 5-LOX was the source of ROIs and was required for NF-kappaB activation in these cells. IL-1beta stimulation of epithelial cells did not generate any ROIs and NF-kappaB induction was not influenced by 5-LOX inhibitors. However, reintroduction of a functional 5-LOX system in these cells allowed ROI production and 5-LOX-dependent NF-kappaB activation. In monocytic cells, IL-1beta treatment led to a production of ROIs which is independent of the 5-LOX enzyme but requires the NADPH oxidase activity. This pathway involves the Rac1 and Cdc42 GTPases, two enzymes which are not required for NF-kappaB activation by IL-1beta in epithelial cells. In conclusion, three different cell-specific pathways lead to NF-kappaB activation by IL-1beta: a pathway dependent on ROI production by 5-LOX in lymphoid cells, an ROI- and 5-LOX-independent pathway in epithelial cells, and a pathway requiring ROI production by NADPH oxidase in monocytic cells.  (+info)

Multiple target sites of allelic imbalance on chromosome 17 in Barrett's oesophageal cancer. (5/18479)

Twelve Barrett's adenocarcinomas have been analysed for the occurrence of allelic imbalance (LOH) on chromosome 17 using 41 microsatellite markers. This study provides evidence for 13 minimal regions of LOH, six on 17p and seven on 17q. Four of these centre in the vicinity of the known tumour suppressor genes (TSGs) TP53 (17p13.1), NFI (17q11.2), BRCA1 (17q21.1), and a putative TSG (17p13.3). The tumours all displayed relatively small regions of LOH (1-10 cM), and in several tumours extensive regions of LOH were detected. One tumour displayed only two very small regions of LOH; 17p11.2 and 17p13.1. The frequency of allelic imbalance has been calculated based on the LOH encompassing only one minimal region, and based on all the LOH observations. By both evaluations the highest LOH frequencies were found for regions II (p53), III (17p13.1 centromeric to p53), IV (17p12), V (17p11.2) and VII (NF1, 17q11.2). Our data supports the existence of multiple TSGs on chromosome 17 and challenges the view that p53 is the sole target of LOH on 17p in Barrett's adenocarcinoma.  (+info)

In vivo isolated kidney perfusion with tumour necrosis factor alpha (TNF-alpha) in tumour-bearing rats. (6/18479)

Isolated perfusion of the extremities with high-dose tumour necrosis factor alpha (TNF-alpha) plus melphalan leads to dramatic tumour response in patients with irresectable soft tissue sarcoma or multiple melanoma in transit metastases. We developed in vivo isolated organ perfusion models to determine whether similar tumour responses in solid organ tumours can be obtained with this regimen. Here, we describe the technique of isolated kidney perfusion. We studied the feasibility of a perfusion with TNF-alpha and assessed its anti-tumour effects in tumour models differing in tumour vasculature. The maximal tolerated dose (MTD) proved to be only 1 microg TNF-alpha. Higher doses appeared to induce renal failure and a secondary cytokine release with fatal respiratory and septic shock-like symptoms. In vitro, the combination of TNF-alpha and melphalan did not result in a synergistic growth-inhibiting effect on CC 531 colon adenocarcinoma cells, whereas an additive effect was observed on osteosarcoma ROS-1 cells. In vivo isolated kidney perfusion, with TNF-alpha alone or in combination with melphalan, did not result in a significant anti-tumour response in either tumour model in a subrenal capsule assay. We conclude that, because of the susceptibility of the kidney to perfusion with TNF-alpha, the minimal threshold concentration of TNF-alpha to exert its anti-tumour effects was not reached. The applicability of TNF-alpha in isolated kidney perfusion for human tumours seems, therefore, questionable.  (+info)

Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation. (7/18479)

Both experimental and clinical research have shown that hyperthermia (HT) gives valuable additional effects when applied in combination with radiotherapy (RT). The purpose of this study was evaluation of results in patients with recurrent breast cancer, treated at the Daniel den Hoed Cancer Center (DHCC) with reirradiation (re-RT; eight fractions of 4 Gy twice weekly) combined with HT. All 134 patients for whom such treatment was planned were included in the analysis. The complete response rate in 119 patients with macroscopic tumour was 71%. Including the 15 patients with microscopic disease, the local control rate was 73%. The median duration of local control was 32 months, and toxicity was acceptable. The complete response (CR) rate was higher, and the toxicity was less with the later developed 433-MHz HT technique compared with the 2450-MHz technique used initially. With this relatively well-tolerated treatment, palliation by local tumour control of a worthwhile duration is achieved in the majority of patients. The technique used for hyperthermia appeared to influence the achieved results. The value of HT in addition to this re-RT schedule has been confirmed by a prospective randomized trial in a similar patient group. In The Netherlands, this combined treatment is offered as standard to patients with breast cancer recurring in previously irradiated areas.  (+info)

Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results. (8/18479)

Fourteen patients with metastatic pancreatic adenocarcinoma were treated with the long-acting somatostatin (SST) analogue lanreotide. No objective response was obtained, and the median survival was 4 months (range 1.8-7 months). Pancreatic cancer could not be visualized by means of SST-receptor (R) scintigraphy in our patients. In vitro data also demonstrated absence of SSTR2 expression, suggesting pancreatic cancer not to be a potential target for treatment with SST analogues.  (+info)

TY - JOUR. T1 - Expression of Das-1 in primary lung adenocarcinomas represents reactivation of an oncofetal pulmonary antigen. AU - Deshpande, C. G.. AU - Shah, R. N.. AU - Yeldandi, A.. AU - Papreddy, K.. AU - Badve, S.. PY - 2002/12/1. Y1 - 2002/12/1. N2 - Objective: The monoclonal antibody (mAb) designated as mAb Das-1 was generated against a colonic epithelial protein. It reacts with bronchiolar epithelium and submucosal glands and weakly with alveolar lining cells of fetal lung. Adult alveolar epithelium is, however, nonreactive for mAb Das-1. The present study was designed to evaluate the immunoexpression of Das-1 and to correlate it with the histomorphology of primary lung adenocarcinomas and intestinal metaplasia. Methods: Eighty-four cases of primary lung adenocarcinomas were reviewed and categorized according to histologic grade and subtype. Immunohistochemical staining with mAb Das-1 was performed with normal colon as control. Results: Expression of Das-1 in the submucosal bronchial ...
In the present study, we demonstrated PCV and EGFR mutation status as independent prognostic factors in untreated advanced lung adenocarcinoma patients. We also showed that PCV , 2.2 ng/ml was a predictor of a favorable outcome in both advanced lung adenocarcinoma patients with wild-type and mutant EGFR.. Serum CYFRA 21-1 has been reported as a prognostic factor in patients with a variety of cancer types, including resectable NSCLC [39, 40], biliary tract cancer [41], urothelial cancer [42], head and neck cancer [43], esophageal cancer [44], and cervical cancer [45].. A meta-analysis of CYFRA 21-1 as a prognostic indicator in advanced NSCLC patients showed that the PCV may be a reliable prognostic factor [29], however, since non-adenocarcinoma accounted for 65% of the cases and squamous cell carcinoma for 50%, the role of serum CYFRA 21-1 as a prognostic indicator in the lung adenocarcinoma population remained unclear. Moreover, in a study of PCV as a prognostic indicator in advanced NSCLC ...
Licorice and its components have been reported to posses various anti-tumor activities, but its active ingredients and underlying mechanisms are not well understood yet. In the present study, a group of representative licorice-derived compounds that could be detected in rat plasma or urine were screened for anti-tumor activity. Among these compounds, isoangustone A (IAA) was found to promptly Inhibit the viability of SW480 human colorectal adenocarcinoma cells in a time- and concentration-dependent manner. Further analyses indicate that IAA activated caspase-dependent pro-apoptotic signaling and induced significant apoptosis, while had little effect on cell cycle. IAA strongly inhibited Akt phosphorylation within 5 min; however, overexpression of constitutively activated Akt could not rescue IAA-mediated inhibition, indicating that inhibition of Akt was not involved in IAA-induced apoptosis. Further examinations show that IAA induced dissipation of mitochondria membrane potential and release of ...
Previous studies have observed that carboxyl-terminal binding protein 1 (CtBP1) is highly expressed in several malignant tumors, such as breast, glioma and prostate tumors, and it was found to play a role in cancer development (5,6,9,10). However, the expression pattern and biological functions of CtBP1 in lung adenocarcinoma remain largely unknown. The present study aimed to address this by examining the expression patterns of CtBP1 in lung adenocarcinoma tissues, its correlation to clinicopathological features, and its effects on the malignant behavior of lung cancer cells. As such, it represents the first investigation of the clinical significance of CtBP1 expression in lung adenocarcinoma patients. Using IHC, we found that CtBP1 was upregulated in lung adenocarcinoma patients with lymph node metastasis. Moreover, CtBP1 expression was strongly associated with tumor differentiation, size and with poor overall survival of lung adenocarcinoma patients. These data suggest that CtBP1 may act as an ...
Cell lines are invaluable tools for biomedical research. Cancer cell lines are the foundation of cancer biology and the quest for drug treatments. Adenocarcinoma is a cancer of the epithelium (including colon) and originates in glandular tissue, such as skin surface layer and glands.. Product. These human adenocarcinoma cell lines have been previously licensed to commercial parties for research into human adenocarcinoma treatments.. These cell lines are available through Public Health England ECACC. Please make your purchase through the links below.. Imperial Innovations requests that commercial/for profit parties contact them first to discuss the terms of supply prior to Innovations authorising the release of supplies from ECACC.. ...
TY - JOUR. T1 - Anterior gradient 2 is correlated with EGFR mutation in lung adenocarcinoma tissues. AU - Narumi, Sodai. AU - Miki, Yasuhiro. AU - Hata, Shuko. AU - Ebina, Masahito. AU - Saito, Mikiyoshi. AU - Mori, Kazushige. AU - Kobayashi, Makoto. AU - Suzuki, Takashi. AU - Iwabuchi, Erina. AU - Sato, Ikuro. AU - Maemondo, Makoto. AU - Endo, Chiaki. AU - Inoue, Akira. AU - Kondo, Takashi. AU - Yamada-Okabe, Hisafumi. AU - Ichinose, Masakazu. AU - Sasano, Hironobu. PY - 2015/4/1. Y1 - 2015/4/1. N2 - Background: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) has demonstrated a promising therapeutic response in lung adenocarcinoma patients with EGFR gene mutations. However, the predictive factors for this therapy have not been established, except for the EGFR gene mutation status of carcinoma cells. Methods: We first performed microarray analysis in EGFR-TKI-sensitive lung adenocarcinoma cell lines. The results indicated anterior gradient 2 (AGR2) as a potential ...
Gastric cancer is one of the most common malignancies worldwide. In this study, we screened for genes upregulated in gastric cancer by comparing gene expression profiles from serial analysis of gene expression and microarray and identified the palate, lung, and nasal epithelium carcinoma-associated protein (PLUNC) gene. Immunostaining for PLUNC in 140 gastric cancer cases revealed strong and extensive staining of PLUNC in hepatoid adenocarcinoma of the stomach, whereas 727777677340f conventional gastric cancer cases showed focal immunostaining of PLUNC. Gastric hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphologic similarities to hepatocellular carcinoma. To investigate the utility of PLUNC immunostaining in the diagnosis of gastric hepatoid adenocarcinoma, six cases of gastric hepatoid adenocarcinoma (six primary tumors and two associated liver metastases) were studied further. PLUNC staining was observed in all six primary hepatoid adenocarcinomas. PLUNC staining was ...
Gastric cancer is one of the most common malignancies worldwide. In this study, we screened for genes upregulated in gastric cancer by comparing gene expression profiles from serial analysis of gene expression and microarray and identified the palate, lung, and nasal epithelium carcinoma-associated protein (PLUNC) gene. Immunostaining for PLUNC in 140 gastric cancer cases revealed strong and extensive staining of PLUNC in hepatoid adenocarcinoma of the stomach, whereas 727777677340f conventional gastric cancer cases showed focal immunostaining of PLUNC. Gastric hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphologic similarities to hepatocellular carcinoma. To investigate the utility of PLUNC immunostaining in the diagnosis of gastric hepatoid adenocarcinoma, six cases of gastric hepatoid adenocarcinoma (six primary tumors and two associated liver metastases) were studied further. PLUNC staining was observed in all six primary hepatoid adenocarcinomas. PLUNC staining was ...
BioAssay record AID 102327 submitted by ChEMBL: Cytotoxicity activity on LoVo/Dx human adenocarcinoma cell line after 1 hr of drug exposure.
TY - JOUR. T1 - Diagnostic utility of thyroid transcription factor-1 expression in adenocarcinomas presenting in serous fluids. AU - Afify, Alaa M. AU - Al-Khafaji, Basim M.. PY - 2002. Y1 - 2002. N2 - OBJECTIVE: To evaluate the diagnostic utility of the immunohistochemical expression of thyroid transcription factorr-1 (TTF-1) in adenocarcinomas from serous fluid specimens. STUDY DESIGN: Archival paraffin-embedded cell blocks of serous fluids from 82 cases, including 34 cases of metastatic lung adenocarcinoma, 12 of metastatic ovarian adenocarcinoma, 12 of metastatic breast adenocarcinoma, 12 of metastatic gastrointestinal adenocarcinoma and 12 of malignant mesothelioma, were immunostained with anti-TTF-1. All the staining was carried out using a Ventana Automated System. Staining was evaluated according to the intensity of the nuclear staining (1+ to 4+) by two observers. RESULTS: Of the metastatic lung adenocarcinomas, 79% (27/34) expressed 3+ to 4+ reactivity against TTF-1. None of the ...
Mickey, D D.; Stone, K R.; Wunderli, H; Mickey, G H.; Vollmer, R T.; and Paulson, D F., Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice. (1977). Subject Strain Bibliography 1977. 30 ...
Adenocarcinomas metastatic to brain from lung or colon may pose differentiation difficulties. Ultrastructurally, both may have brush borders with rootlets. This study examines the ultrastructural morphology and immunohistochemical expression of villin (associated with rootlets), cytokeratin 7 (present in lung adenocarcinomas), and cytokeratin 20 (present in colon adenocarcinomas) in 19 formalin-fixed sequential surgical biopsies of lung adenocarcinomas metastatic to brain as compared to 13 colonic adenocarcinoma metastases. Of lung tumor metastases, mucinous differentiation with rootlets was most common [6/19(32%)]. All colon tumor metastases were cytokeratin 7(-), 20(+), and profusely villin(+). Well-formed rootlets were seen. All lung metastases were cytokeratin 7(+) and 20(-). 5/6(83%) lung metastases with rootlets were focally villin(+). 12/13(95%) without rootlets were villin(-). Rootlets are extremely common in lung adenocarcinoma metastatic to brain. Villin immunoreactivity closely correlates
Purpose: The microRNA-34b/c (miR-34b/c) is considered a tumor suppressor in different tumor types and a transcriptional target of TP53. The main objectives of this study were to investigate the clinical implications of miR-34b/c methylation in patients with early-stage lung adenocarcinoma and to determine the functional role of miR-34b/c re-expression in lung adenocarcinoma cell lines.. Experimental Design: Aberrant methylation and expression of miR-34b/c were assessed in 15 lung adenocarcinoma cell lines and a cohort of 140 early-stage lung adenocarcinoma. Lung adenocarcinoma cell lines were transfected with miR-34b/c and the effects upon cell proliferation, migration, invasion, and apoptosis were investigated.. Results: Aberrant methylation of miR-34b/c was detected in 6 (40%) of 15 lung adenocarcinoma cell lines and 64 of 140 (46%) primary lung adenocarcinoma. Expression of miR-34b/c was significantly reduced in all methylated cell lines and primary tumors, especially with TP53 mutations. ...
MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / metabolism. Adenocarcinoma / secondary. Adenocarcinoma, Clear Cell / drug therapy. Adenocarcinoma, Clear Cell / metabolism. Adenocarcinoma, Clear Cell / secondary. Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / secondary. Adult. Aged. Angiotensin II Type 1 Receptor Blockers / pharmacology. Animals. Apoptosis / drug effects. Benzimidazoles / pharmacology. Blotting, Western. Carcinoma, Medullary / drug therapy. Carcinoma, Medullary / metabolism. Carcinoma, Medullary / secondary. Case-Control Studies. Cell Proliferation / drug effects. Disease Progression. Electrophoretic Mobility Shift Assay. Female. Humans. Immunoenzyme Techniques. Inhibitor of Apoptosis Proteins. Male. Mice. Mice, Inbred BALB C. Mice, Nude. Middle Aged. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / metabolism. Peritoneal Neoplasms / pathology. Receptor, Angiotensin, Type 1 / chemistry. Receptor, ...
Cisplatin (Csp) is a recurrently used chemotherapeutic drug but its use is inadequate due to undesirable adverse effects. In search of alternative medicine more attention has been given to phytochemicals. Septilin (Spt), a polyherbal drug and its therapeutic potential is huge but there is a scarcity of studies on its cytotoxic potential on cancer cells. The current study was designed to examine the effects of Spt in combination with Csp on human breast adenocarcinoma (MCF-7) and normal human breast epithelial (MCF-10A) cell lines. Cell viability for Spt treated cells was studied using MTT assay. IC50 value of Csp on MCF-7 cells was found to be 10 µg/mL at 24 h. This dose was further used to study the combined effects of Csp with Spt on MCF-7 and MCF-10A cell lines. Maximum cytotoxicity of Spt on MCF-7 cells was observed at Spt 5 µg/mL. The mechanism of Spt induced cytotoxicity was studied using apoptosis assay. Spt did not show any cytotoxic effects on MCF-10 A normal human breast epithelial ...
BACKGROUND/AIM AXL (anexelekto) has been explored as a potential novel therapeutic target for non-small cell lung carcinoma (NSCLC) but its activation status has not been evaluated in NSCLC. PATIENTS AND METHODS We first immunolocalized the phosphorylated form of AXL in 112 lung adenocarcinoma cases and subsequently evaluated the anti-neoplastic effects of monoclonal antibody AXL in two lung adenocarcinoma cell lines, PC9 and A549. RESULTS Phospho-AXL immunoreactivity was detected in 59.8% of adenocarcinoma cases examined and tended correlate significantly with larger tumor size (p=0.08) and with overall survival of the patients (p=0.041). Results of in vitro analysis revealed that the monoclonal antibody to AXL significantly inhibited cell proliferation of PC9 and A549, lung adenocarcinoma cell lines, which was caused by an inhibition of extracellular signal-regulated kinase (ERK) activation. CONCLUSION AXL-targeted therapy, possibly through inhibiting ERK activation of carcinoma cells, could
The aim of the present study was to investigate the association between serum levels of matrix metalloproteinase 11 (MMP-11) and responses to front-line chemotherapy and prognosis in advanced unresectable gastric adenocarcinoma. Clinical data concerning 86 patients with advanced gastric adenocarcinoma (stages III c to IV), treated in Beijing Chao-Yang Hospital from 2005 to 2009, were reviewed retrospectively. Adenocarcinoma was confirmed by pathology and patients received 5-fluorouracil-based front-line combination chemotherapy with third generation chemotherapeutic agents including paclitaxel, docetaxel and oxaliplatin. The regimen was repeated every two to three weeks, and the first evaluation was carried out after three cycles. The median cycle of chemotherapy was 6 (ranging from three to twelve cycles). Serum MMP-11 protein from the 86 patients was examined using enzyme-linked-immunosorbent-assay (ELISA) prior to chemotherapy and after three cycles of chemotherapy. Serum samples from healthy
TY - JOUR. T1 - The impact of smoking and tp53 mutations in lung adenocarcinoma patients with targetable mutations-the lung cancer mutation consortium (LCMC2). AU - Aisner, Dara L.. AU - Sholl, Lynette M.. AU - Berry, Lynne D.. AU - Rossi, Michael R.. AU - Chen, Heidi. AU - Fujimoto, Junya. AU - Moreira, Andre L.. AU - Ramalingam, Suresh S.. AU - Villaruz, Liza C.. AU - Otterson, Gregory A.. AU - Haura, Eric. AU - Politi, Katerina. AU - Glisson, Bonnie. AU - Cetnar, Jeremy. AU - Garon, Edward B.. AU - Schiller, Joan. AU - Waqar, Saiama N.. AU - Sequist, Lecia V.. AU - Brahmer, Julie. AU - Shyr, Yu. AU - Kugler, Kelly. AU - Wistuba, Ignacio I.. AU - Johnson, Bruce E.. AU - Minna, John D.. AU - Kris, Mark G.. AU - Bunn, Paul A.. AU - Kwiatkowski, David J.. PY - 2018/3/1. Y1 - 2018/3/1. N2 - Purpose: Multiplex genomic profiling is standard of care for patients with advanced lung adenocarcinomas. The Lung Cancer Mutation Consortium (LCMC) is a multi-institutional effort to identify and treat ...
Metastatic adenocarcinoma from an unknown primary site is a common clinical problem. Determining the cytokeratin (CK) 7/CK20 pattern of tumors is one of the most helpful procedures for this purpose since the CK7-/CK20+ pattern is typical of colorectal adenocarcinomas. CDX2, a critical nuclear transcription factor for intestinal development, is expressed in intestinal epithelium and adenocarcinomas. In the present study, we compared the sensitivity and specificity of CDX2 expression and the CK7-/CK20+ phenotype in differentiating colorectal adenocarcinomas from pancreatic and gastric adenocarcinomas. CK7/CK20 staining pattern and CDX2 expression were evaluated in 118 cases of colorectal, 59 cases of gastric, and 32 cases of pancreatic adenocarcinomas. The sensitivity, specificity, and positive and negative predictive values of the CK7-/CK20+ phenotype and of CDX2 expression were analyzed. The CK7-/CK20+ immunophenotype was expressed by 75 of 118 (64%) colorectal and 3 of 59 (5%) gastric tumors and was
p21WAF1/CIP1 protein is a cyclin-dependent kinase inhibitor, discovered to be a downstream effector of p53-dependent cell cycle regulation. In order to elucidate the significance of p21 expression in lung adenocarcinomas, we performed immunohistochemical analysis of p21, p53 and Ki-67 expression in surgically resected lung adenocarcinomas. In non-neoplastic tissue, a few bronchial and bronchiolar suprabasal and ciliated cells, and a few type II alveolar cells and alveolar macrophages in the peripheral lung, were p21 positive, but the positive rate in normal lung tissue was very low (,1%). All 91 lung adenocarcinomas examined showed p21 immunoreactivity: 39 cases (42.9%) and 52 cases (57.1%) showed high and low p21 expression levels, respectively. There was no significant correlation between p21 expression and p53 expression, the loss of heterozygosity status of the p53 gene, histological grade determined by the predominant histology, lymph node metastasis, pathological stage, tumor size, smoking ...
Cell lines are invaluable tools for biomedical research. Cancer cell lines are the foundation of cancer biology and the quest for drug treatments. Adenocarcinoma is a cancer of the epithelium (including colon) and originates in glandular tissue, such as skin surface layer and glands.. Product. These human adenocarcinoma cell lines have been previously licensed to commercial parties for research into human adenocarcinoma treatments.. These cell lines are available through Public Health England ECACC. Please make your purchase through the links below.. Imperial Innovations requests that commercial/for profit parties contact them first to discuss the terms of supply prior to Innovations authorising the release of supplies from ECACC.. ...
MUC1 protein is highly expressed in lung cancer. The cytoplasmic domain of MUC1 (MUC1-CD) induces tumorigenesis and resistance to DNA-damaging agents. We characterized MUC1-CD-induced transcriptional changes and examined their significance in lung cancer patients. Using DNA microarrays, we identified 254 genes that were differentially expressed in cell lines transformed by MUC1-CD compared to control cell lines. We then examined expression of these genes in 441 lung adenocarcinomas from a publicly available database. We employed statistical analyses independent of clinical outcomes, including hierarchical clustering, Students t-tests and receiver operating characteristic (ROC) analysis, to select a seven-gene MUC1-associated proliferation signature (MAPS). We demonstrated the prognostic value of MAPS in this database using Kaplan-Meier survival analysis, log-rank tests and Cox models. The MAPS was further validated for prognostic significance in 84 lung adenocarcinoma patients from an independent
BACKGROUND. The decline of gastric adenocarcinoma in the U. S. and the parallel decrease in the predominance of the intestinal type of gastric adenocarcinoma may reflect, in part, changes in diet over the last 60 years. Because the intestinal and diffuse types of gastric adenocarcinoma may be epidemiologically distinct, the authors hypothesized...
Non-small cell lung cancer (NSCLC) includes lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). MicroRNA (miRNA) plays an important role in the regulation of post-transcriptional gene expression in animals and plants, especially in lung adenocarcinoma. MiR-1307-5p is an miRNA with significant differences screened by the second generation of high-throughput sequencing in the early stage of our research group. In the current study, a series of in vitro and in vivo experiments were carried out. MiR-1307-5p mimic, miR-1307-5p inhibitor, and NC were transfected into A549 and H1299 lung adenocarcinoma cells. The correlation between miR-1307-5p and clinicopathological features in pathological samples was analyzed using a lung adenocarcinoma tissue microarray, and miR-1307-5p expression was detected by qPCR. CCK-8, EdU, colony formation, scratch test, and Transwell assays were used to observe cell proliferation and migration. Double luciferase assay, western blot, qPCR, and immunohistochemistry
Adenocarcinoma[1] (/ˌædᵻnoʊkɑːrsᵻˈnoʊmə/; plural adenocarcinomas oradenocarcinomata /ˌædᵻnoʊkɑːrsᵻˈnoʊmᵻtə/) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandularorigin, glandular characteristics, or both. Adenocarcinomas are part of the larger grouping ofcarcinomas, but are also sometimes called by more precise terms omitting the word, where these exist. Thus invasive ductal carcinoma, the most common form of breast cancer, is adenocarcinoma but does not use the term in its name-however, esophageal adenocarcinoma does to distinguish it from the other common type of esophageal cancer, esophageal squamous cell carcinoma. Several of the most common forms of cancer are adenocarcinomas, and the various sorts of adenocarcinoma vary greatly in all their aspects, so that few useful generalizations can be made about them. ...
Introduction : Cancer cells, compared to normal cells, are under increased oxidative stress associated with oncogenic transformation, alterations in metabolic activity, and increased generation of reactive oxygen species. Material and methods : We investigated the ability of vitamin C to...
Adenocarcinoma (/ˌædɪnoʊkɑːrsɪˈnoʊmə/; plural adenocarcinomas or adenocarcinomata /ˌædɪnoʊkɑːrsɪˈnoʊmɪtə/) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandular origin, glandular characteristics, or both. Adenocarcinomas are part of the larger grouping of carcinomas, but are also sometimes called by more precise terms omitting the word, where these exist. Thus invasive ductal carcinoma, the most common form of breast cancer, is adenocarcinoma but does not use the term in its name-however, esophageal adenocarcinoma does to distinguish it from the other common type of esophageal cancer, esophageal squamous cell carcinoma. Several of the most common forms of cancer are adenocarcinomas, and the various sorts of adenocarcinoma vary greatly in all their aspects, so that few useful generalizations can be made about them. In the most specific usage (narrowest sense), the glandular origin or traits ...
This study will compare the efficacy of azacitidine versus observation in patients with pancreatic cancer at high risk of recurrence.
TY - JOUR. T1 - Neoadjuvant treatment of pancreatic adenocarcinoma. T2 - A systematic review and meta-analysis of 5520 patients. AU - Dhir, Mashaal. AU - Malhotra, Gautam K.. AU - Sohal, Davendra P.S.. AU - Hein, Nicholas A.. AU - Smith, Lynette M.. AU - OReilly, Eileen M.. AU - Bahary, Nathan. AU - Are, Chandrakanth. PY - 2017/10/10. Y1 - 2017/10/10. N2 - Background: Recent years have seen standardization of the anatomic definitions of pancreatic adenocarcinoma, and increasing utilization of neoadjuvant therapy (NAT). The aim of the current review was to summarize the evidence for NAT in pancreatic adenocarcinoma since 2009, when consensus criteria for resectable (R), borderline resectable (BR), and locally advanced (LA) disease were endorsed. Methods: PubMed search was undertaken along with extensive backward search of the references of published articles to identify studies utilizing NAT for pancreatic adenocarcinoma. Abstracts from ASCO-GI 2014 and 2015 were also searched. Results: A total ...
Introduction: Lung adenocarcinoma has a complex variety of different hystopathologic subtypes with distinct epidemiology, pathology and prognosis. Pulmonary adenocarcinoma with enteric differentiation is a rare variant defined as a tumor with more than 50% of colorrectal-like components, immunohistochemistry (IHC) positive for at least one marker of enteric differentiation (CK20, CDX-2 or MUC2) and no evidence of other malignancies. Case Series: Patients were identified in a review of a set of adenocarcinomas, apparently originated in colon, but posteriorly accessed as lung adenocarcinomas. Median age was 57.6 years, were all Caucasian subjects and presented with metastatic disease. The median size were 6.3 cm at the time of diagnosis and all had spiculated shape forms at CT scans. Microscopic description revealed a lepidic (mucinous) adenocarcinoma in all five cases. Immunohistochemistry were positive for CK20 or CDX-2 in all these cases and was negative for CK7 in one patient. Conclusion: The use of
Dr. Bin Wang developed the investigational vaccine used in this clinical trial and designed the trial protocol.For patients with advanced esophageal squamous carcinoma, gastric adenocarcinoma, pancreatic adenocarcinoma and colorectal adenocarcinoma tumor who have disease progression with first line chemotherapy. Single or multiple doses of personalized mRNA tumor vaccine encoding neoantigen will be given to observe the safety and efficacy the mRNA tumor vaccine.. Primary objectives:. Determine the safety, tolerability and cytokinetics of the personalized mRNA tumor vaccine in patients with advanced esophageal squamous carcinoma, gastric adenocarcinoma, pancreatic adenocarcinoma and colorectal adenocarcinoma.. Secondary objectives:. Make a preliminary evaluation on the efficacy of personalized mRNA tumor vaccine in patients with advanced esophageal squamous carcinoma, gastric adenocarcinoma, pancreatic adenocarcinoma and colorectal adenocarcinoma with the following parameters:. Time of tumor ...
Several SOX genes are involved in lung development and may have functional roles within the lung. SOX9 (a transcription factor) has been shown to be involved in several types of cancer. In this lab-based study, SOX9 expression was investigated in 29 lung adenocarcinoma and 28 normal lung samples using silico data mining, quantitative reverse transcription-PCR and immunohistochemistry.. SOX9 was upregulated at both the mRNA and protein level in the majority of lung adenocarcinomas compared with normal tissue. In addition, recurrent lung adenocarcinoma tissue showed significantly higher SOX9 expression than that of a primary lesion. RNA interference technique and microarray gene expression further demonstrated that knockdown of SOX9 inhibited cell growth, downregulated CDK4 and upregulated p21. These are all important cell cycle regulators and their expression could mediate SOX9-related alteration in cancer cell growth.. SOX9 may be an important biomarker in lung adenocarcinoma which could aid in ...
Despite advances in surgery, radiotherapy, and chemotherapy, pancreatic adenocarcinoma often progresses rapidly and causes death. The physical decline of these patients is expected to impact their quality of life (QoL). Therefore, in addition to objective measures of effectiveness, the evaluation of health-related QoL should be considered a matter of major concern when assessing therapy outcomes. Observational, prospective, multicenter study including patients with metastatic pancreatic adenocarcinoma who started first-line chemotherapy in 12 Spanish centers. Treatment and clinical characteristics were recorded at baseline. Patients health-related quality of life, ECOG, and Karnofsky index were measured at baseline, at Days 15 and 30, and every four weeks up to 6 months of chemotherapy. Health-related quality of life was measured using the EORTC-QLQ-C30 and EQ-5D questionnaires. Other endpoints included overall survival and progression-free survival. The study sample included 116 patients (median age
Despite encouraging clinical results with sorafenib monotherapy in patients with KRAS-mutant non-small-cell lung cancer (NSCLC), the overall survival benefit of this drug is limited by the inevitable development of acquired resistance. The exact mechanism underlying acquired sorafenib resistance in KRAS-mutant NSCLC is unclear. In this study, the mechanism of acquired sorafenib resistance was explored using a biologically relevant xenograft model, which was established by using the A549 human lung adenocarcinoma cell line and an in vivo-derived, sorafenib-resistant A549 subline (A549/SRFres). Results from the initial study demonstrated that sorafenib treatment significantly decreased E-cadherin (P , 0.05) levels but significantly increased matrix metallopeptidase 9 (MMP9) levels (P , 0.01) in A549/SRFres tumors, whereas expression levels of phospho-protein kinase B (AKT), phospho-focal adhesion kinase (FAK), and phospho-Src were elevated in sorafenib-treated A549 and A549/SRFres tumors. We next ...
Metastatic lung cancer is common in lung adenocarcinoma patients, but the molecular mechanisms of metastasis remain incompletely resolved. MicroRNA (miR) regulate gene expression and contribute to cancer development and progression. This report identifies miR-576-3p and its mechanism of action in lung cancer progression. miR-576-3p was determined to be significantly decreased in clinical specimens of late-stage lung adenocarcinoma. Overexpression of miR-576-3p in lung adenocarcinoma cells decreased mesenchymal marker expression and inhibited migration and invasion. Inhibition of miR-576-3p in non-malignant lung epithelial cells increased migration and invasion as well as mesenchymal markers. Serum/glucocorticoid regulated kinase 1 (SGK1) was a direct target of miR-576-3p, and modulation of miR-576-3p levels led to alterations in SGK1 protein and mRNA as well as changes in activation of its downstream target linked to metastasis, N-myc downstream regulated 1 (NDRG1). Loss of the ability of ...
Background: Tumor budding has recently been reported as an independent adverse prognostic factor for colorectal adenocarcinomas and other types of carcinoma in the digestive tract. This study aimed to evaluate the prognostic value of tumor budding in patients with early-stage cervical adenocarcinomas and any associations with other clinical and pathological features. Methods: Histological slides of patients with early-stage (IB-IIA) usual-type endocervical adenocarcinoma who underwent radical hysterectomy and pelvic lymph node dissection, without preoperative chemotherapy, between January 2006 and December 2012 were reviewed. Tumor budding was evaluated in routinely-stained sections and defined as detached single cells or clusters of fewer than 5 cells in a tumor invasive front and was stratified based on the number of bud counts in 10-high-power fields as low (follow-up outcomes were assessed. Results: Of 129 patients, a high tumor bud count was observed in 15 (11.6%), positively associated with
The correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma patients: a single center case series
Background: A steep increase in the incidence of esophageal adenocarcinoma has been observed between 1973 and 2001, but recent trends have not been reported. Our aim was to examine recent trends in esophageal adenocarcinoma incidence.. Methods: We used the Surveillance Epidemiology and End Results database of the National Cancer Institute to identify all patients who were diagnosed with esophageal adenocarcinoma between 1973 and 2006. Incidence trends were analyzed for esophageal adenocarcinoma overall and by stage using joinpoint regression.. Results: Overall esophageal adenocarcinoma incidence increased from 3.6 per million in 1973 to 25.6 per million in 2006. Incidence trend analysis, however, suggests that the increase has slowed, from an 8.2% annual increase prior to 1996 to 1.3% increase in subsequent years (P = 0.03). Stage-specific trend analyses suggest that the change in overall esophageal adenocarcinoma incidence largely reflects a plateau in the incidence of early stage disease. Its ...
A macrophage-mediated antibody-dependent cellular cytotoxic reaction has been described in a syngeneic murine mammary adenocarcinoma model. The antibody appears to be present in two forms, one apparently complexed with antigen and the other identified as 7S immunoglobulin on Sephadex G-200 and as the IgG2a subclass by blocking of Fc receptors on the macrophages. This antibody is first detected in mice with regressing tumors. Tumor cells from immune mice appear to be coated with this antibody, as they are sensitive to the effects of normal macrophages in vitro, whereas tumor cells from immunologically compromised mice are not. Thus, a macrophage-dependent reaction probably is relevant in the in situ immune defenses against this tumor.. ...
We report an SB insertional mutagenesis screen to identify loci that cooperate with oncogenic Kras to drive pancreatic adenocarcinoma in the mouse. SB-driven pancreatic adenocarcinomas show all stages of mPanIN that develop into early noninvasive adenocarcinoma and finally, invasive, highly metastatic adenocarcinoma. Importantly, these tumors also have a high desmoplastic component, a predominant histopathic feature of human pancreatic cancer. The T2Onc3 transposon proved to be more potent than T2Onc2 in inducing metastatic tumors. The exact mechanism for the difference between the two transposons in driving pancreatic cancer is unknown. One possibility is that the location of the transposon concatemer donor influences the development of the tumor. The T2Onc3 donor resides on chromosome 9, and pancreatic cancer genes in close proximity may be frequently mutated in these tumors because of local hopping.. Both T2Onc2 and T2Onc3 cohorts exhibited considerably higher numbers of nonredundant ...
The p63 gene is a recently discovered member of the p53 family located at chromosome 3q27Many studies have reported that overexpression of p63 can mimic p53 activities by binding DNA, activating transcription, and inducing apoptosis.. Various studies proved p63 as a marker of basal cells in normal salivary glands, breast, prostate, respiratory and squamous epithelia, and of tumor cells from various malignancies. Still, p63 has been the subject of relatively few studies in lung adenocarcinoma, and breast carcinoma, and no study has described the correlation of p63 with pancreatic ductal adenocarcinoma.. In the current study, we aim to evaluate the prognostic value of the expression of p63 in the lung adenocarcinoma, breast adenocarcinoma, and pancreatic ductal adenocarcinoma. We will achieve this aim by collecting clinical data retrospectively from the patients medical records as well as assessing the histological sections and performing immunohistochemical staining for p63. ...
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Nectin-like molecule-5 (Necl-5) is an immunoglobulin (Ig)-like molecule that is up-regulated in many types of cancer cells. It was shown experimentally that Necl-5 enhances cell migration, proliferation, and metastasis, but its clinical significance has not been documented. The aim of this study was to observe the expression of Necl-5 in surgically resected primary lung adenocarcinomas and to investigate its clinical significance. A total of 63 surgically resected primary pulmonary adenocarcinoma tissues were investigated by immunohistochemistry for the expression of Necl-5. The relationship between expression of Necl-5 and clinicopathological features was analyzed, and the influence of Necl-5 expression on outcomes in these patients was assessed. A strong expression of Necl-5 by cancer cells was observed in 43 of the 63 tumors. The overexpression of Necl-5 by cancer cells was significantly associated with lymph node metastasis (P = 0.0398), TNM staging (P = 0.0367), and the bronchioloalveolar ...
BioAssay record AID 52959 submitted by ChEMBL: Antitumor activity against colon 26 murine adenocarcinoma cells expressed as percent TGI (tumor growth inhibition) at 0.0313 mg/kg i.v. compound dose.
Medical information, Adenocarcinoma of the bronchus. Definition of Adenocarcinoma of the bronchus, symptoms of Adenocarcinoma of the bronchus, treatment of Adenocarcinoma of the bronchus, and prevention of Adenocarcinoma of the bronchus. Exams and Tests Adenocarcinoma of the bronchus.
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Identification of the primary sites of metastatic adenocarcinomas is a diagnostic problem, particularly in cases of occult primary neoplasms. We studied the ultrastructural morphology of 16 metastatic adenocarcinomas that presented as effusions to establish organ-specific features that would characterize adenocarcinomas from various sites. The nine cases in which the site of the primary carcinoma was known included seven derived from the breast, one from the ovary and one from the colon. The primary site was unknown in seven cases at the time of presentation. After investigations, the primary site became known in five cases (lung, colon and appendix, one case each, and the ovary in two cases). Ultrastructurally diagnostic features could be detected in gastrointestinal, ovarian, bronchioloalveolar-cell and breast carcinomas. In gastrointestinal carcinomas, the presence of short microvilli with long rootlets was specific for the group. The lamellar inclusions of type II pneumocytes were diagnostic ...
PURPOSE: To better understand the complete genomic architecture of lung adenocarcinoma. EXPERIMENTAL DESIGN: We used array experiments to determine copy number variations and sequenced the complete exomes of the 247 lung adenocarcinoma tumor samples along with matched normal cells obtained from the same patients. Fully annotated clinical data were also available, providing an unprecedented opportunity to assess the impact of genomic alterations on clinical outcomes. RESULTS: We discovered that genomic alternations in the RB pathway are associated with significantly shorter disease-free survival in early-stage lung adenocarcinoma patients. This association was also observed in our independent validation cohort. The current treatment guidelines for early-stage lung adenocarcinoma patients recommend follow-up without adjuvant therapy after complete resection, except for high-risk patients. However, our findings raise the interesting possibility that additional clinical interventions might provide medical
TY - JOUR. T1 - Tumor volume and lymphovascular space invasion as a prognostic factor in early invasive adenocarcinoma of the cervix. AU - Murakami, Isao. AU - Fujii, Takuma. AU - Kameyama, Kaori. AU - Iwata, Takashi. AU - Saito, Miyuki. AU - Kubushiro, Kaneyuki. AU - Aoki, Daisuke. PY - 2012/6. Y1 - 2012/6. N2 - Objective: The aim of this study was to investigate the risk and recurrence of early invasive adenocarcinoma of the cervix, and to determine whether non-radical methods of management could be performed. Methods: The medical and histopathological records of 50 patients with early invasive adenocarcinoma of the cervix treated at Keio University Hospital between 1993 and 2005 were reviewed, and compared with the literature. Results: The median follow-up period was 64.3 months. The depth of stromal invasion was ≤3 mm in 33 cases and ,3 mm, but ≤5 mm in 17 cases. The horizontal spread was ≤7 mm in 25 cases and ,7 mm in 25 cases. One of the 33 cases that had tumor volumes of ≤500 mm ...
TY - JOUR. T1 - Mutations of the EGFR, K-ras, EML4-ALK, and BRAF genes in resected pathological stage I lung adenocarcinoma. AU - Ohba, Taro. AU - Toyokawa, Gouji. AU - Osoegawa, Atsushi. AU - Hirai, Fumihiko. AU - Yamaguchi, Masafumi. AU - Taguchi, Ken ichi. AU - Seto, Takashi. AU - Takenoyama, Mitsuhiro. AU - Ichinose, Yukito. AU - Sugio, Kenji. N1 - Publisher Copyright: © 2015, Springer Japan. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2016/9/1. Y1 - 2016/9/1. N2 - Background and purpose: The EGFR, K-ras, EML4-ALK, and BRAF genes are oncogenic drivers of lung adenocarcinoma. We conducted this study to analyze the mutations of these genes in stage I adenocarcinoma. Methods: The subjects of this retrospective study were 256 patients with resected stage I lung adenocarcinoma. We analyzed mutations of the EGFR, K-ras, and BRAF genes, and the EML4-ALK fusion gene. We also assessed disease-free survival (DFS) to evaluate the prognostic value and overall survival (OS) to ...
Introduction: Over the past decade potatoes with purple- and red-fleshed color rich in antioxidants (phenolic compounds - phenolic acids, anthocyanins etc.) have attracted the attention of consumers and scientists due to their appearance, flavour and biological properties. It is assumed that they have the potential to be an important source of biologically active compounds in the human nutrition and beneficial for human health. The aim of this study was to investigate whether potato tubers with coloured flesh might suppress human gastric adenocarcinoma cells (AGS cells) proliferation and viability. Object and methods: The field experiment was conducted in 2017 and 2018 on farm in Širvintos district (Lithuania). The study was implemented with 5 potato cultivars (Solanum tuberosum L) with different coloured flesh. In the conventional farming system the mix of universal complex fertilizers (Blaukorn Novatec N14P7K17) was used during potato crops vegetative period by inserting the 112 kg ha-1 ...
Mechanisms behind the strong associations of esophageal adenocarcinoma risk with gastroesophageal reflux (GOR) and body mass remain to be defined. In a nationwide population-based case-control study, we examined associations of polymorphisms in the DNA repair genes XPD, XPC, XRCC1 and XRCC3 with risk of esophageal adenocarcinoma, squamous-cell carcinoma (SCC) and gastric cardia adenocarcinoma, and paid special attention to possible interactions with symptomatic reflux or body mass. We collected blood samples from 96, 81 and 126 interviewed incident cases of esophageal adenocarcinoma, esophageal SCC and gastric cardia adenocarcinoma, respectively, and 472 randomly selected controls, frequency-matched with regard to age and sex. DNA was extracted and polymorphisms in XPD codon 751 (Lys→Gln), codon 312 (Asp→Asn), C insertion in intron 10 of XPD, XPC codon 939 (Lys→Gln), XRCC1 codon 399 (Arg→Gln) and XRCC3 codon 241 (Thr→Met) were examined using PCR-RFLP. Odds ratios (ORs) derived from ...
TY - JOUR. T1 - Stable transduction of human pancreatic adenocarcinoma cells, rat fibroblasts, and bone marrow-derived stem cells with recombinant adeno- associated virus containing the rat preproisulin II gene. AU - Bochan, M. R.. AU - Sidner, R. A.. AU - Shah, R.. AU - Cummings, O. W.. AU - Goheen, M.. AU - Jindal, R. M.. PY - 1998/1/1. Y1 - 1998/1/1. UR - http://www.scopus.com/inward/record.url?scp=0031978015&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0031978015&partnerID=8YFLogxK. U2 - 10.1016/S0041-1345(97)01353-5. DO - 10.1016/S0041-1345(97)01353-5. M3 - Article. C2 - 9532125. AN - SCOPUS:0031978015. VL - 30. SP - 453. EP - 454. JO - Transplantation Proceedings. JF - Transplantation Proceedings. SN - 0041-1345. IS - 2. ER - ...
TY - JOUR. T1 - Small intestinal adenocarcinoma in Crohns disease. T2 - A case-control study. AU - Solem, Craig A.. AU - Harmsen, W. Scott. AU - Zinsmeister, Alan R.. AU - Loftus, Jr, Edward Vincent. PY - 2004/1. Y1 - 2004/1. N2 - Background: Small bowel adenocarcinoma is an uncommon complication of Crohns disease. We sought to describe the clinical features, outcomes, and risk factors of small bowel adenocarcinoma in Crohns disease. Methods: A centralized diagnostic index identified all patients with Crohns disease with small bowel adenocarcinoma evaluated at our institution between 1976 and 2000, and the medical records were abstracted. Two controls with Crohns disease were selected for each case, matched by gender and age. Results: Nine cases (four males) were identified. The patients presented with abdominal pain (89%), obstruction (89%), and weight loss (78%). Cancer was located in the ileum in 8 patients (89%) and the jejunum in 1 patient (11%). All cases but 1 had either lymph node ...
Results 253 incident EAC, 191 gastric cardia adenocarcinomas and 125 gastric non-cardia adenocarcinomas accrued to the cohort. Overall obesity (BMI) was positively associated with EAC and gastric cardia adenocarcinoma risk (highest (≥35 kg/m2) vs referent (18.5-,25 kg/m2); HR 2.11, 95% CI 1.09 to 4.09 and HR 3.67, 95% CI 2.00 to 6.71, respectively). Waist circumference was also positively associated with EAC and gastric cardia adenocarcinoma risk (highest vs referent; HR 2.01, 95% CI 1.35 to 3.00 and HR 2.22, 95% CI 1.43 to 3.47, respectively), whereas waist-to-hip ratio (WHR) was positively associated with EAC risk only (highest vs referent; HR 1.81, 95% CI 1.24 to 2.64) and persisted in patients with normal BMI (18.5-,25 kg/m2). Mutual adjustment of WHR and BMI attenuated both, but did not eliminate the positive associations for either with risk of EAC. In contrast, the majority of the anthropometric variables were not associated with adenocarcinomas of the gastric non-cardia. ...
TY - JOUR. T1 - A phase i study of IMP321 and gemcitabine as the front-line therapy in patients with advanced pancreatic adenocarcinoma. AU - Wang-Gillam, Andrea. AU - Plambeck-Suess, Stacey. AU - Goedegebuure, Peter. AU - Simon, Peter O.. AU - Mitchem, Jonathan B.. AU - Hornick, John R.. AU - Sorscher, Steven. AU - Picus, Joel. AU - Suresh, Rama. AU - Lockhart, Albert. AU - Tan, Benjamin. AU - Hawkins, Williams G.. PY - 2013/6/1. Y1 - 2013/6/1. N2 - Purpose This phase I study was conducted to determine the safety profile and maximum tolerated dose (MTD) of IMP321, a soluble lymphocyte activation gene-3 (LAG-3) Ig fusion protein and MHC Class II agonist, combined with gemcitabine in patients with advanced pancreatic adenocarcinoma. Patients and methods Patients with advanced pancreatic adenocarcinoma were treated with gemcitabine (1,000 mg/m2)(level 1), gemcitabine (1,000 mg/m 2) plus IMP 321 at 0.5 mg (level 2) and 2.0 mg (level 3), respectively. Safety, toxicity, and immunological markers at ...
TY - JOUR. T1 - Irinotecan, docetaxel and oxaliplatin combination in metastatic gastric or gastroesophageal junction adenocarcinoma. AU - Di Lauro, L.. AU - Nunziata, C.. AU - Arena, M. G.. AU - Foggi, P.. AU - Sperduti, I.. AU - Lopez, M.. PY - 2007/8/28. Y1 - 2007/8/28. N2 - This phase II study was designed to evaluate the activity and safety of a combination of irinotecan, docetaxel and oxaliplatin in metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma. Forty patients with measurable distant metastasis received irinotecan 150 mg m-2 and docetaxel 60 mg m-2 on day 1, and oxaliplatin 85 mg m-2 on day 2. Cycles were repeated every 3 weeks. The primary end point was to demonstrate a 50% improvement in time-to-progression (TTP) over historical controls. All patients were evaluable. Median TTP was 6.5 months (95% confidence interval (CI) 5.6-7.4), the overall response rate was 50% (95% CI 35-65%) and the median overall survival was 11.5 months (95% CI 8.7-14.3). Grade 3/4 ...
TY - JOUR. T1 - Metastatic prostatic adenocarcinoma mimicking inflammatory breast carcinoma. T2 - A case report. AU - Njiaju, Uchenna O.. AU - Truica, Cristina I.. PY - 2010/2/1. Y1 - 2010/2/1. N2 - Prostate adenocarcinoma can manifest as a fairly indolent tumor or as a very aggressive cancer with significant invasive and metastatic potential. Common metastatic sites include bone, liver, lymph nodes, and adrenal glands. Dermatologic manifestations are rare. We present a case of a man who presented with breast skin changes that mimicked inflammatory breast carcinoma with specialized testing ultimately giving a diagnosis of metastatic prostatic adenocarcinoma. A 78-year-old man presented with left breast redness and swelling. Examination revealed an erythematous rash with subcutaneous edema over the left hemithoracic area. A breast ultrasound showed no focal mass, and a breast core biopsy had no evidence of tumor. A skin biopsy showed metastatic carcinoma in dermal lymphatics, and the tumor was ...
This study is a single arm, single center phase II study of AZD5363 in combination with paclitaxel in patients with advanced gastric adenocarcinoma harboring
Background The prognosis of patients with gastroesophageal adenocarcinoma is poor. There is conflicting evidence regarding effects of preoperative chemotherapy on survival and other outcomes. Methods We conducted a meta-analysis with aggregate and individual patient data (IPD) to assess the effect of preoperative chemotherapy for gastroesophageal adenocarcinoma on survival and other outcomes. Two independent reviewers identified eligible randomised controlled trials (RCTs) comparing chemotherapy+/-radiotherapy followed by surgery with surgery alone for gastroesophageal adenocarcinoma. IPD was solicited from all trials. Meta-analyses were performed using the two stage method. Results We identified 14 RCTs (2422 patients). For eight RCTs (1049 patients; 43.3%) we obtained IPD. Preoperative chemotherapy was associated with longer overall survival (hazard ratio [HR] 0.81; 95% confidence interval [CI] 0.73-0.89; p < 0.0001). There were larger treatment effects in tumours of the gastroesophageal ...
BACKGROUND: Obesity is associated with an increased incidence of oesophageal and oesophagogastric junction adenocarcinoma, in particular Siewert types I and II. This study compared abdominal fat composition in patients with oesophageal/junctional adenocarcinoma with that in patients with oesophageal squamous cell carcinoma and gastric adenocarcinoma, and in controls. METHOD: In total, 194 patients (110 with oesophageal/junctional adenocarcinoma, 38 with gastric adenocarcinoma and 46 with oesophageal squamous cell carcinoma) and 90 matched control subjects were recruited. The abdominal fat area was assessed using computed tomography (CT), and the total fat area (TFA), visceral fat area (VFA) and subcutaneous fat area (SFA) were calculated. RESULTS: Patients with oesophageal/junctional adenocarcinoma had significantly higher TFA and VFA values compared with controls (both P , 0.001), patients with gastric adenocarcinoma (P = 0.013 and P = 0.006 respectively) and patients with oesophageal squamous ...
MalaCards based summary : Barretts Adenocarcinoma, also known as barrett adenocarcinoma, is related to barrett esophagus and adenocarcinoma. An important gene associated with Barretts Adenocarcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Endometrial cancer. Affiliated tissues include lymph node, bone and heart, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2) ...
Proximal oesophageal cancers are predominantly squamous cell cancer (SCC), with adenocarcinoma constituting approximately 10% of the cases.1 An inlet patch is an area of heterotopic gastric mucosa found in the proximal oesophagus in up to 10% of the population, and adenocarcinoma can develop from this patch, although rarely.2 3 Adenocarcinoma is not as sensitive to radiation as SCC, but surgery for this case would have required resection of the larynx, pharynx and oesophagus, and in combination with locally advanced disease, these considerations underpinned a management decision to treat with radical chemoradiation.. The likely causation of localised metastatic tumour development in this case was malignant cell capture on the PEG bolster when drawn through the obstructing tumour site, with implantation in the stomach wall, and subsequent external progression. A meta-analysis reports the overall rate of PEG site metastasis from upper aerodigestive tract cancers as approximately 0.5%, with 74 ...
TY - JOUR. T1 - Phase II trial of salvage therapy with trabectedin in metastatic pancreatic adenocarcinoma. AU - Belli, Carmen. AU - Piemonti, Lorenzo. AU - DIncalci, Maurizio. AU - Zucchetti, Massimo. AU - Porcu, Luca. AU - Cappio, S.. AU - Doglioni, Claudio. AU - Allavena, Paola. AU - Ceraulo, D.. AU - Maggiora, Paola. AU - Dugnani, Erica. AU - Cangi, Mariagiulia. AU - Garassini, Greta. AU - Reni, Michele. PY - 2016/3/1. Y1 - 2016/3/1. N2 - Purpose: No standard salvage chemotherapy has been identified for metastatic pancreatic adenocarcinoma (mPA), and there is an urgent need for active agents against this disease. This phase II trial explored the activity of trabectedin in mPA progressing after gemcitabine-based first-line chemotherapy. Methods: Patients with gemcitabine-resistant disease received trabectedin 1.3 mg/m2 as a 3-h intravenous continuous infusion every 3 weeks until disease progression or unacceptable toxicity or for a maximum of 6 months. The primary endpoint was ...
The role of estrogen in the growth and survival of ovarian cancer cells is controversial. In this study, we investigated the changes in cell-cycle regulatory proteins in ovarian cancer cell lines after estrogen treatment to explore the role of estrog
Pancreatic ductal adenocarcinoma (PDAC) is usually incurable. Contrary to genetic mechanisms involved in PDAC pathogenesis, epigenetic alterations are ill defined. Here, we determine the contribution of epigenetically silenced genes to the development of PDAC. We analyzed enriched, highly methylated DNAs from PDACs, chronic pancreatitis (CP) and normal tissues using CpG island microarrays and identified WNK2 as a prominent candidate tumor suppressor gene being downregulated early in PDAC development. WNK2 was further investigated in tissue microarrays, methylation analysis of early pancreatic intraepithelial neoplasia (PanIN), mouse models for PDAC and pancreatitis, re-expression studies after demethylation, and cell growth assays using WNK2 overexpression. Demethylation assays confirmed the link between methylation and expression. WNK2 hypermethylation was higher in tumor than in surrounding inflamed tissues and was observed in PanIN lesions as well as in a PDAC mouse model. WNK2 mRNA and protein
TY - JOUR. T1 - Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress. AU - Katakura, Yoshinori. AU - Yoshizaki, Kaichi. AU - Yasuda, Tomoharu. AU - Tsunematsu, Takahiro. AU - Uehara, Norihisa. AU - Miura, Takumi. AU - Fujiki, Tsukasa. AU - Shirahata, Sanetaka. PY - 2005/8/26. Y1 - 2005/8/26. N2 - We investigated the effects of a sublethal concentration of H 2O2 on cancer cells by using sublines derived from human lung adenocarcinoma cell line A549 cells exposed to 200 μM H 2O2. These sublines (AST cells) showed an elongated morphology distinct from the rounded morphology of A549 cells. Notably, AST cells demonstrated telomere shortening despite displaying telomerase activity and expressing human telomerase reverse transcriptase (hTERT). This functional impairment of telomerase occurred due to perturbed subcellular localization of hTERT in AST cells. Endogenous as well as ectopically expressed hTERT was localized in the nuclei of ...
Bone is the most common site of metastasis for breast cancer, however the reasons for this remain unclear. We hypothesise that under certain conditions mammary cells possess osteomimetic capabilities that may allow them to adapt to, and flourish within, the bone microenvironment. Mammary cells are known to calcify within breast tissue and we have recently reported a novel in vitro model of mammary mineralization using murine mammary adenocarcinoma 4T1 cells. In this study, the osteomimetic properties of the mammary adenocarcinoma cell line and the conditions required to induce mineralization were characterized extensively. It was found that exogenous organic phosphate and inorganic phosphate induce mineralization in a dose dependent manner in 4T1 cells. Ascorbic acid and dexamethasone alone have no effect. 4T1 cells also show enhanced mineralization in response to bone morphogenetic protein 2 in the presence of phosphate supplemented media. The expression of several bone matrix proteins were monitored
TY - JOUR. T1 - Esophageal Adenocarcinoma Cells and Xenograft Tumors Exposed to Erb-b2 Receptor Tyrosine Kinase 2 and 3 Inhibitors Activate Transforming Growth Factor Beta Signaling, Which Induces Epithelial to Mesenchymal Transition. AU - Ebbing, Eva A.. AU - Steins, Anne. AU - Fessler, Evelyn. AU - Stathi, Phylicia. AU - Lesterhuis, Willem Joost. AU - Krishnadath, Kausilia K.. AU - Vermeulen, Louis. AU - Medema, Jan Paul. AU - Bijlsma, Maarten F.. AU - van Laarhoven, Hanneke W. M.. PY - 2017. Y1 - 2017. N2 - Drugs that inhibit the erb-b2 receptor tyrosine kinase 2 (ERBB2 or HER2) are the standard treatment of patients with different types of cancer, including HER2-overexpressing gastroesophageal tumors. Unfortunately, cancer cells become resistant to these drugs, so overall these drugs provide little benefit to patients with these tumors. We investigated mechanisms that mediate resistance of esophageal adenocarcinoma (EAC) cells and patient-derived xenograft tumors to ERBB inhibitors. We ...
TY - JOUR. T1 - Consistent genetic alterations in xenografts of proximal stomach and gastro-esophageal junction adenocarcinomas. AU - El-Rifai, Wael. AU - Harper, Jeffrey C.. AU - Cummings, Oscar W.. AU - Hyytinen, Eija Riitta. AU - Frierson, Henry F.. AU - Knuutila, Sakari. AU - Powell, Steven M.. PY - 1998/1/1. Y1 - 1998/1/1. N2 - The genetic alterations underlying the development of gastric and gastro-esophageal carcinoma remain largely undefined. DNA copy number changes were determined by comparative genomic hybridization in eight xenografts of proximal gastric and gastro-esophageal junction adenocarcinomas of the intestinal type. All tumors exhibited DNA copy number changes, with a total of 139 changes detected (range, 11-24 per tumor; mean = 17), indicating numerous and widespread alterations within these cancers. Gains (65%) in DNA copy number were more frequent than losses (35%). Our most striking finding was gain (all eight cases) or high-level amplification (four cases) in 20q, with a ...
Background: Metastatic pancreatic adenocarcinoma has a short median overall survival (OS) of 5-6 months. However, a subgroup of patients survives more than 1 year. We analyzed the survival outcomes of this subgroup and evaluated clinical and pathological factors that might affect survival durations. Methods: We identified 20 patients with metastatic or recurrent pancreatic adenocarcinoma who received single-agent gemcitabine and had an OS longer than 1 year. Baseline data available after the diagnosis of metastatic or recurrent disease was categorized as: 1) clinical/demographic data (age, gender, ECOG PS, number and location of metastatic sites); 2) Laboratory data (Hematocrit, hemoglobin, glucose, LDH, renal and liver function and CA19-9); 3) Pathologic data (margins, nodal status and grade); 4) Outcomes data (OS, Time to Treatment Failure (TTF), and 2 year-OS). The lowest CA19-9 levels during treatment with gemcitabine were also recorded. We performed a univariate analysis with OS as the ...
Both the androgen and glucocorticoid receptors of the Pollard prostate adenocarcinoma cell lines (PA-II and PA-III) have been examined and characterized. Both cell lines contains distinct binding site...
TY - JOUR. T1 - High level expression of fms proto-oncogene mRNA is observed in clinically aggressive human endometrial adenocarcinomas. AU - Kacinski, Barry M.. AU - Carter, Darryl. AU - Mittal, Khushbakhat. AU - Kohorn, Ernest I.. AU - Bloodgood, R. Shaeffer. AU - Donahue, John. AU - Donofrio, Lisa. AU - Edwards, Rob. AU - Schwartz, Peter E.. AU - Chambers, Joseph T.. AU - Chambers, Setsuko K.. PY - 1988. Y1 - 1988. N2 - Six micron paraffin sections of paraformaldehyde-fixed endometrial currettings of 21 benign and neoplastic endometrial specimens were assayed for tumor cell-specific oncogene expression by in situ hybridization with probes for six oncogenes, beta-actin, and the E. coli plasmid pBR322. In the benign hyperplasias and invasive adenocarcinomas, multiple oncogenes, including erbB, fms, c-myc, and Ki-ras were expressed at significant levels. For the adenocarcinomas, statistical analysis demonstrated that high levels of expression of fms-complementary mRNA correlated strongly with ...
Primary pulmonary mucinous adenocarcinoma (PPMA) is an uncommon subtype of lung adenocarcinoma. The present study attempted to clarify the diagnosis, clinicopathological characteristics, and pathologic significance of epithelial growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) mutations and the prognosis of PPMA. A total of 29 patients with PPMA from among 1,469 surgically resected patients with lung adenocarcinoma were enrolled. All of the tumours expressed CK7 and 5 cases exhibited co‑expression with CK20. A total of 8 cases expressed EGFR, 14 cases expressed P53 and 2 cases expressed CEA. The majority of mucinous adenocarcinomas expressed thyroid transcription factor 1, Napsin A, Villin and Cam5.2 proteins. KRAS mutations were observed in 62% of patients and were more prevalent in the lower lung lobe and in patients with invasive mucinous adenocarcinoma. A total of 2 cases exhibited an EGFR mutation, and the co‑mutation of KRAS and EGFR was only detected in 1 ...
The present invention includes a method of utilizing four peptide hormones to inhibit the growth of cancer(s). A dramatic decrease in the number of human pancreatic adenocarcinoma cells (i.e., the type of cancer with the highest mortality, with patients only surviving four months) was observed responsive to treatment. The application of the invention would be to utilize one or more of these peptide hormones alone and/or in combination to treat cancer. The ability of these peptide hormones to decrease the number of adenocarcinoma cells has implications for adenocarcinomas at other sites in the body with the majority of cancers of the breast, colon and prostate also being adenocarcinomas. Adenocarcinomas also occur in the lung and other tissues. Treatment of a wide variety of cancers in addition to adenocarcinomas is anticipated by the present invention.
TY - JOUR. T1 - Use of hormone replacement therapy and adenocarcinomas and squamous cell carcinomas of the uterine cervix. AU - Lacey, James V.. AU - Brinton, Louise A.. AU - Barnes, Willard A.. AU - Gravitt, Patti E.. AU - Greenberg, Mitchell D.. AU - Hadjimichael, Olympia C.. AU - McGowan, Larry. AU - Mortel, Rodrigue. AU - Schwartz, Peter E.. AU - Kurman, Robert J. AU - Hildesheim, Allan. PY - 2000/4. Y1 - 2000/4. N2 - Introduction. Exogenous hormones may influence the development of cervical adenocarcinomas. Incidence rates of adenocarcinomas and use of noncontraceptive hormones have increased since the 1970s, but few studies have investigated this potential relationship. Methods. We conducted a multicenter case-control study of 124 women with adenocarcinomas, 139 women with squamous cell carcinomas matched on age, diagnosis date, clinic, and stage of disease (in situ or invasive) to adenocarcinoma cases, and 307 healthy community controls who were also matched on age, ethnicity, and ...
Although hydroxyurea is one of the most widely used drugs in treating breast cancer, the use of it leads to some side effects. Hence, in order to reduce complications of treatment and increase its efficiency, drug delivery has been attracted more attention. Present study included three stages. The first stage was involved in the synthesis of nanoparticles-loaded hydroxyurea that its characteristics were evaluated by using scanning electron microscopy and Zetasizer system. In the second stage, cultured MCF-7 cells were undergone treatments by hydroxyurea and Nanoparticles-loaded hydroxyurea in various concentrations. In the third stage, the MCF-7 was treated by IC50 of hydroxyurea and nanoparticles-loaded hydroxyurea which are in combination with radiation and hyperthermia. Afterward, the viable of cell, apoptosis, and levels of caspase-8 and-9 proteins were assessed. The average size and the potential surface of nanoparticles and nanoparticles-loaded hydroxyurea were 26 nm, 48 nm, 3.86 mV, and -29.3 mV
TY - JOUR. T1 - Calretinin staining pattern aids in the differentiation of mesothelioma from adenocarcinoma in serous effusions. AU - Chhieng, David C.. AU - Yee, Herman. AU - Schaefer, Dawn. AU - Cangiarella, Joan F.. AU - Jagirdar, Jaishree. AU - Chiriboga, Luis A.. AU - Cohen, Jean Marc. PY - 2000/6/25. Y1 - 2000/6/25. N2 - BACKGROUND. The differentiation between malignant mesothelioma and adenocarcinoma based on morphology alone can be a diagnostic challenge. The majority of the available antibodies recognize molecules expressed by adenocarcinoma whereas to the authors knowledge specific markers for mesothelial cells are lacking. Calretinin, a calcium-binding protein, has been reported to be a selective marker for mesothelioma and largely is absent from adenocarcinoma on histologic material. The results with cytologic preparations have been inconsistent. METHODS. To evaluate the specificity of calretinin in differentiating mesothelioma from adenocarcinoma in cytologic preparations, 21 ...
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Looking for online definition of nonbronchioalveolar adenocarcinoma in the Medical Dictionary? nonbronchioalveolar adenocarcinoma explanation free. What is nonbronchioalveolar adenocarcinoma? Meaning of nonbronchioalveolar adenocarcinoma medical term. What does nonbronchioalveolar adenocarcinoma mean?
Emerging evidence supports the idea that a dysfunction in cell metabolism could sustain a resistant phenotype in cancer cells. As the success of chemotherapeutic agents is often questioned by the occurrence of multidrug resistance (MDR), a multiple cross-resistance towards different anti-cancer drugs represent a major obstacle to cancer treatment. The present study has clarified the involvement of the carbon metabolites in a more aggressive tumor colon adenocarcinoma phenotype and in a chemoresistant mesothelioma, and the role of pyruvate treatment in the reversion of the potentially related resistance. For the first time, we have shown that human colon adenocarcinoma cells (HT29) and its chemoresistant counterpart (HT29-dx) displayed different carbon metabolism: HT29-dx cells had a higher glucose consumption compared to HT29 cells, whereas human malignant mesothelioma (HMM) cells showed a lower glucose consumption compared to HT29 cells, accompanied by a lower pyruvate production and, ...
Histone deacetylases (HDACs) have been associated with malignant tumor development and progression in humans. HDAC inhibitors (HDACIs) are currently being explored as anti-cancer agents in clinical trials. The present study aimed to evaluate the clinical significance of HDAC-1, −2, −4 and −6 protein expression in pancreatic adenocarcinoma. HDAC-1, −2, −4 and −6 protein expression was assessed immunohistochemically on 70 pancreatic adenocarcinoma tissue specimens and was statistically analyzed with clinicopathological characteristics and patients survival. Enhanced HDAC-1 expression was significantly associated with increased tumor proliferative capacity (p = 0.0238) and borderline with the absence of lymph node metastases (p = 0.0632). Elevated HDAC-4 expression was significantly associated with the absence of organ metastases (p = 0.0453) and borderline with the absence of lymph node metastases (p = 0.0571) and tumor proliferative capacity (p = 0.0576). Enhanced HDAC-6 expression was
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma ...
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma ...
BEVILACQUA, Roberta A.U.; CORVELLO, Cassandra M.; DUARTE, Ana Paula and SIMPSON, Andrew J.G.. Detection of microsatellite instability but not truncating APC mutations in gastric adenocarcinomas in Brazilian patients. Genet. Mol. Biol. [online]. 2000, vol.23, n.2, pp.255-259. ISSN 1415-4757. https://doi.org/10.1590/S1415-47572000000200001.. A crucial role for the adenomatous polyposis colonic (APC) gene in colorectal carcinogenesis has been conclusively established, but, the role of APC in gastric tumors remains controversial. APC mutations have been detected at a relatively high frequency in gastric tumors of Japanese patients, yet such mutations have been reported to be extremely rare in British patients and patients from north-central-Italy. We here report the analysis of 40 primary sporadic gastric adenocarcinomas and 35 primary sporadic colon adenocarcinomas (from patients resident in São Paulo, Brazil), for mutations in the APC gene between codons 686 and 1693 using the protein truncation ...
Colorectal epithelium is composed of absorptive, mucous and endocrine cells, all of which are considered to arise from a common stem cell located in the crypt base. However, the factors controlling the commitment to differentiate are poorly understood. This is partly due to the lack of in vitro model systems for the study of differentiation in colorectal epithelium. The HRA-19 cell line, established from a human rectal adenocarcinoma, has been shown to have multipotential characteristics with cloned HRA-19 cells able to differentiate into absorptive, mucous and endocrine cells when grown as xenografts. The lack of such differentiated cells in HRA-19 monolayers in vitro suggests that differentiation is controlled by extracellular matrix, stromal cells and/or soluble factors. Such observations show that differentiation in HRA-19 cells can be controlled by extrinsic factors and therefore provide a model system for studying control of differentiation in colorectal epithelium. Unfortunately, the ...
AZD9291 is a novel, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), which is administered orally. It has been proven effective in non-small cell lung cancer (NSCLC) patients, with both EGFR-sensitizing and EGFR T790M mutations in preclinical models. However, the potential therapeutic effects of AZD9291 combined with other modalities, including ionizing radiation, are not well understood. The presence of AZD9291 significantly increases the cell-killing effects of radiation in PC-9-IR cells with a secondary EGFR mutation (T790M), which was developed from NSCLC PC-9 cells (human lung adenocarcinoma cell with EGFR 19 exon 15 bp deletion) after chronic exposure to increasing doses of gefitinib, and in H1975 cells (human lung adenocarcinoma cell with EGFR exon 20 T790M mutation de novo), but not in PC-9 cells or in H460 cells (human lung adenocarcinoma cell with wild-type EGFR ...
Although primary duodenal adenocarcinoma (DA) is a rare malignancy representing ~ 0.5% of all gastrointestinal cancers, the incidence of DA is more frequent in Lynch syndrome. Because of its rarity, treatment strategies or optimal chemotherapeutic regimens have not been clearly defined for advanced DA. A 72-year-old woman with Lynch syndrome visited our hospital with a right upper abdominal pain. Computed tomography (CT) showed wall thickness with enhancement in the second portion of the duodenum and adjacent abdominal wall, which suggested direct tumor invasion to the abdominal wall. Upper gastrointestinal endoscopy (UGE) showed a large ulcerative tumor in the second portion of the duodenum, and histological analysis revealed a poorly differentiated adenocarcinoma. A cT4N0M0, cStage IIB (Union for International Control Cancer TNM staging) DA was diagnosed. After three courses of chemotherapy with S-1 and oxaliplatin (SOX), follow-up CT and UGE showed shrinkage of the duodenal tumor. Therefore, the
TY - JOUR. T1 - Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. AU - Mc Williams, Robert R. AU - Bamlet, William R.. AU - Cunningham, Julie M. AU - Goode, Ellen L. AU - De Andrade, Mariza. AU - Boardman, Lisa Allyn. AU - Petersen, Gloria M. PY - 2008/6/15. Y1 - 2008/6/15. N2 - Base excision repair and nucleotide excision repair are vital responses to multiple types of DNA damage, including damage from tobacco exposure. Single-nucleotide polymorphisms (SNP)in these pathways may affect DNA repair capacity and therefore influence risk for cancer development. We performed a clinic-based, case-control study comprising 481 consecutive patients with confirmed pancreatic adenocarcinoma and 625 healthy controls. Allele and genotype frequencies for 16 SNPs in DNA repair genes ERCC1, XPD/ERCC2, XPC, XPF/ERCC4, OGG1, and XRCC1 were compared after adjusting for age, sex, and smoking history. Subgroup analysis by sex and smoking history was performed. Carriers of one or two ...
We hypothesized that tumors exposed to high levels of IGF1R ligands are dependent on IGF1R for growth and survival. This would manifest as enhanced sensitivity to tumor inhibition of IGF1R in patients with high levels of ligands or of IGFBP-3, a binding protein that stabilizes circulating ligands and is cleaved by local proteases to release ligands at the tissue level. The functions of the other binding proteins are not well characterized but may sequester ligands in circulation and away from tissues; therefore, low levels of these binding proteins would promote IGF1R ligand availability and thus tumor dependence on IGF1R.. In this phase II study of ganitumab and gemcitabine in metastatic pancreatic adenocarcinoma, baseline levels of circulating factors of the IGF axis were evaluated for potential associations with survival. The treatment effect of ganitumab was enhanced in patients with higher baseline levels of total IGF-1, IGF-2, and IGFBP-3 and lower baseline levels of IGFBP-2 as compared ...
A subepitheal myofibroblastic (SMF) cell layer has been described in the colon, and referred to as pericryptal myofibroblastic cell layer. SMF cells have been shown to produce basement membrane proteins, including type IV collagen and laminin. The aim of this work was to determine the status of the SMF cell layer in Barretts metaplasia (BM), with and without dysplasia, and compare that to the previously reported distribution of SMF in normal colon and colonic adenomas and carcinoma. Sections of formalin-fixed, paraffin-embedded biopsies from 6 colonic adenomas and 5 colonic adenocarcinomas, as well as 4 cases of BM without dysplasia, 4 with low grade dysplasia, 4 high grade dysplasia and 4 with invasive adenocarcinoma were immunohistochemically stained for alpha smooth muscle actin using the immunoperoxidase method. A continuous layer of SMF cells was present in all normal colonic tissue and adenomas but was absent in all colorectal adenocarcinomas. Surprisingly, none of the cases of BM with or without
Background and Objectives: To investigate critical prognostic factors for local recurrence in patients with rectal adenocarcinoma.. Methods: We enrolled 221 consecutive patients who had histologically confirmed adenocarcinoma of the rectum and underwent surgery in our hospital between January 2000 and December 2014. Total mesorectal excision was performed in all patients undergoing a sphincter-sparing procedure or abdominal perineal resection of rectal cancer. To evaluate prognostic factors for local recurrence, we performed univariate and multivariate Cox regression analyses of the local recurrence rate in all patients. Overall survival rates were calculated using the Kaplan-Meier method, and Kaplan-Meier survival curves were compared using the log-rank test.. Results: After the inclusion of only model variables of local recurrence with the highest or lowest univariate risk, a tumor size of ,5 cm, a negative circumferential margin, well-to-moderately differentiated adenocarcinoma, low anterior ...
The Notch pathway has been implicated in a number of malignancies with different roles that are cell- and tissue-type dependent. Notch1 is a putative oncogene in non-small cell lung cancer (NSCLC) and activation of the pathway represents a negative prognostic factor. To establish the role of Notch1 in lung adenocarcinoma, we directly assessed its requirement in Kras-induced tumorigenesis in vivo using an autochthonous model of lung adenocarcinoma with concomitant expression of oncogenic Kras and deletion of Notch1. We found that Notch1 function is required for tumor initiation via suppression of p53-mediated apoptosis through the regulation of p53 stability. These findings implicate Notch1 as a critical effector in Kras-driven lung adenocarcinoma and as a regulator of p53 at a posttranslational level. Moreover, our study provides new insights to explain, at a molecular level, the correlation between Notch1 activity and poor prognosis in patients with NSCLC carrying wild-type p53. This ...
Background: The tumor-stroma ratio (TSR) represents the percentage of neoplastic cell components compared to the combined area of neoplastic cells and the surrounding tumor-induced stroma. A low TSR (predomination of stromal component) has been demonstrated to be an independent adverse prognostic factor in cancers of several organs. In cervical carcinoma patients, TSR has been evaluated in only one previous study with different histological types. The present study aimed to assess the prognostic value of TSR in early stage cervical cancer patients with adenocarcinoma histology only. Materials and Methods: Histological slides of patients with early stage (IB-IIA) cervical adenocarcinoma who underwent surgical treatment between January 2003 and December 2011 were reviewed. Patients who had received preoperative chemotherapy were excluded. TSR was categorized as low (,50%) and high (≥50%). Correlations between TSR and clinicopathological variables were evaluated. Prognostic values of TSR and ...
Clear-cell adenocarcinoma - Type of adenocarcinoma that shows clear cells Fetal adenocarcinoma - Rare subtype of pulmonary ... Media related to Adenocarcinomas at Wikimedia Commons "Adenocarcinoma"-NCI Dictionary of Cancer Terms Surgical Videos, Images ... Several of the most common forms of cancer are adenocarcinomas, and the various sorts of adenocarcinoma vary greatly in all ... Adenocarcinoma (/ˌædɪnoʊkɑːrsɪˈnoʊmə/; plural adenocarcinomas or adenocarcinomata /ˌædɪnoʊkɑːrsɪˈnoʊmɪtə/) (AC) is a type of ...
Ceruminous adenocarcinomas (CA) is a rare type of tumor and has a very small amount of literature on it. The ages to develop ... Ceruminous adenocarcinoma is a malignant neoplasm derived from ceruminous glands of the external auditory canal. This tumor is ... The most common tumor type is ceruminous adenoid cystic carcinoma and ceruminous adenocarcinoma, NOS. Pain is the most common ... The tumors are separated into three main histologic or microscopic types: Ceruminous adenocarcinoma, NOS Ceruminous adenoid ...
Synonyms for FA include well differentiated fetal adenocarcinoma, high-grade fetal adenocarcinoma, pulmonary adenocarcinoma of ... Fetal adenocarcinoma (FA) of the lung is a rare subtype of pulmonary adenocarcinoma that exhibits tissue architecture and cell ... April 2008). "Fetal adenocarcinoma of the lung in a 25-year-old woman". J Thorac Oncol. 3 (4): 441-3. doi:10.1097/JTO. ... Adenocarcinomas are most often highly heterogeneous peripheral tumors, and are thought to arise from malignant transformation ...
... is a histological form of lung cancer that is diagnosed when the malignant cells of the tumor form ...
In Europe, acinar adenocarcinoma may comprise the dominant architectural pattern in as many as 50-60% of all adenocarcinomas. ... Acinar adenocarcinoma is a histological subtype of gland-forming cancer that is diagnosed when cuboidal and/or columnar shaped ... Adenocarcinoma ("adeno" = "gland", "carcinoma" = cancer of epithelium) is the most common type of lung cancer in the U.S., ... Acinar adenocarcinoma of the lung is a highly lethal disease. Overall five-year survival rates approximate 16% to 22%. ...
An anal sac adenocarcinoma is an uncommon and aggressive malignant tumor found in dogs that arises from the apocrine glandular ... Anal sac adenocarcinomas are often suspected due to location (palpable masse in anal sac) and behavior, but a biopsy and ... Mellanby R, Foale R, Friend E, Woodger N, Herrtage M, Dobson J (2002). "Anal sac adenocarcinoma in a Siamese cat". J Feline Med ... Hobson H, Brown M, Rogers K (2006). "Surgery of metastatic anal sac adenocarcinoma in five dogs". Vet Surg. 35 (3): 267-70. doi ...
Enzootic nasal adenocarcinoma Jaagsiekte sheep retrovirus Enzootic nasal tumor virus "2.7.9 Ovine pulmonary adenocarcinoma ( ... Ovine pulmonary adenocarcinoma (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious ... OPA has been used as an animal model for human lung cancer, because OPA is histologically similar to human adenocarcinoma in ... De Las Heras, M; González, L; Sharp, JM (2003). "Pathology of ovine pulmonary adenocarcinoma". In Fan, Hung (ed.). Jaagsiekte ...
... is rare subtype of pulmonary adenocarcinoma. The presentation is similar to that of other lung ... Lin D, Zhao Y, Li H, Xing X (2013) Pulmonary enteric adenocarcinoma with villin brush border immunoreactivity: a case report ... Lin, D; Zhao, Y; Li, H; Xing, X (2013). "Pulmonary enteric adenocarcinoma with villin brush border immunoreactivity: A case ... Journal of Thoracic Disease 5:E17-20 Tsao MS, Fraser RS (1991) Primary pulmonary adenocarcinoma with enteric differentiation. ...
... is a fatal, malignant neoplastic, infectious disease in sheep and goats. It is caused by the ... Ovine pulmonary adenocarcinoma Enzootic nasal tumor virus Jaagsiekte sheep retrovirus v t e (All stub articles, Sheep stubs, ... "A Case of Enzootic Nasal Adenocarcinoma in a Ewe". Case Reports in Veterinary Medicine. 2012: 1-4. doi:10.1155/2012/347193. ... also in sheep and goats called Ovine pulmonary adenocarcinoma (OPA). Symptoms include nasal discharge, dyspnea, facial ...
... is a type of adenocarcinoma that shows clear cells. Types include: Clear-cell adenocarcinoma of the ... vagina Clear-cell ovarian carcinoma Uterine clear-cell carcinoma Clear-cell adenocarcinoma of the lung (which is a type of ...
... (OGJ adenocarcinoma) is a cancer of the lower part of the oesophagus with a rising ... in contrast to the declining frequency of distal gastric adenocarcinoma. Treatment options for adenocarcinomas involving the ... A Type II tumor, located between 1cm proximal and 2cm distal to the OGJ, is a true adenocarcinoma of the gastric cardia. A Type ... OGJ adenocarcinoma is a highly mutated and heterogeneous disease. Microsatellite instability (MSI) can be observed and ...
... is a cutaneous condition characterized by an aggressive malignancy involving the ...
The Prostate Adenocarcinoma: TransCutaneous Hormones (PATCH) study is a large randomized controlled trial in the United Kingdom ... "Prostate Adenocarcinoma TransCutaneous Hormones (PATCH)". ClinicalTrials.gov. U.S. National Library of Medicine. Retrieved 21 ... Prostate Adenocarcinoma TransCutaneous Hormones (PATCH) - ClinicalTrials.gov (Prostate cancer, Clinical trials). ... long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme" ( ...
... H&E stain. Micrograph of a polymorphous low-grade adenocarcinoma. H&E stain. PLGAs are ... It forms glands, i.e. it is an adenocarcinoma. It affects the minor salivary glands in the area between the hard and the soft ... Polymorphous low-grade adenocarcinoma (PLGA) is a rare, asymptomatic, slow-growing malignant salivary gland tumor. It is most ... Paleri V, Robinson M, Bradley P (April 2008). "Polymorphous low-grade adenocarcinoma of the head and neck". Current Opinion in ...
"Adenocarcinoma of the Colon and Rectum". Stanford University School of Medicine. Original posting/updates: 1/31/10, 7/15/11, 11 ... Colorectal adenocarcinoma is distinguished from a colorectal adenoma (mainly tubular and ⁄or villous adenomas) mainly by ... Invasive adenocarcinoma commonly displays: Varying degrees of gland formation with tall columnar cells Frequently desmoplasia ... "Moderately differentiated adenocarcinoma (colon)". pathologyatlas.ro. Archived from the original on January 26, 2016. Robert V ...
Hypertrophic pulmonary osteoarthropathy (HPO) is fairly rare in adenocarcinoma. Less than 1% of patients with adenocarcinoma of ... and is thought to further progress to adenocarcinoma in situ and invasive adenocarcinoma of the lung. The lesions of AAH are ... Adenocarcinoma of the lung is the most common type of lung cancer, and like other forms of lung cancer, it is characterized by ... Adenocarcinoma is more common in patients with a history of cigarette smoking, and is the most common form of lung cancer in ...
... is a rare type of cervical cancer that, in relation to other cervical cancers, is ... A similar lesion, villoglandular adenocarcinoma of the endometrium, may arise from the inner lining of the uterus, the ... "Villoglandular papillary adenocarcinoma of the uterine cervix: a diagnostic challenge". Acta Obstet Gynecol Scand. 88 (3): 355- ... "Villoglandular adenocarcinoma of the endometrium: a clinicopathologic study of 61 cases: a gynecologic oncology group study". ...
Atypical adenomatous hyperplasia of the lung Adenocarcinoma in situ of the lung Adenocarcinoma of the lung Lambe, Gerard; ... Minimally invasive adenocarcinoma of the lung (MIA) is defined as a small (≤3 cm), solitary tumour with predominant alveolar ... For MIA-as with adenocarcinoma in situ-, the prognosis is near 100% survival. ... Durand, Michael; Buckley, Anne; Nicholson, Siobhan; McDermott, Ronan (2020). "Adenocarcinoma of the lung: from BAC to the ...
... lepidic predominant adenocarcinoma), as well as invasive mucinous adenocarcinoma in place of mucinous BAC. Mucinous BAC Non- ... minimally invasive adenocarcinoma, mixed subtype invasive adenocarcinoma, and even widespread disease. In addition to creating ... mucinous BAC Atypical adenomatous hyperplasia of the lung Minimally invasive adenocarcinoma of the lung Adenocarcinoma of the ... Adenocarcinoma in situ (AIS) of the lung -previously included in the category of "bronchioloalveolar carcinoma" (BAC)-is a ...
Clear-cell adenocarcinoma (CCA) of the vagina or cervix is a rare adenocarcinoma often linked to prenatal exposure to ... Clear-cell adenocarcinoma of the vagina is a rare cancer, occurring in up to 10% of primary vaginal malignancies. It is all but ... Clear cell adenocarcinoma entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain ... Some of the main signs and symptoms for clear-cell adenocarcinoma of the vagina are spotting between menstrual cycles, bleeding ...
The most common form of acinar adenocarcinoma, in turn, is "adenocarcinoma, not otherwise specified", also termed conventional ... "Prostatic Adenocarcinoma". Stanford University School of Medicine. Retrieved 2019-10-30. Rao SR, Snaith AE, Marino D, Cheng X, ... The LNCaP cancer cell line was established from a human lymph node metastatic lesion of prostatic adenocarcinoma. PC-3 and DU- ... The region of the prostate gland where the adenocarcinoma is most common is the peripheral zone. Initially, small clumps of ...
Ryan, David P. (September 11, 2014). "Pancreatic Adenocarcinoma". The New England Journal of Medicine. 2014 (371): 1039-1049. ...
These adenocarcinomas start within the part of the pancreas that makes digestive enzymes. Several other types of cancer, which ... Pancreatic adenocarcinoma typically has a very poor prognosis; after diagnosis, 25% of people survive one year and 5% live for ... Typically, pancreatic adenocarcinoma first spreads to nearby lymph nodes, and later to the liver or to the peritoneal cavity, ... Pancreatic adenocarcinoma and the other less common exocrine cancers have a very poor prognosis, as they are normally diagnosed ...
Colorectal adenocarcinoma. Field stain. Granuloma. Field stain. Chunge, CN.; Ngige, S.; Bwibo, CR.; Mulega, PC.; Kilonzo, JF.; ...
Different subtypes of exocrine adenocarcinomas exist, with the most common being pancreatic ductal adenocarcinoma (PDAC). ... Adenocarcinomas are exocrine tumors of the pancreas, which implies that they begin within the part of the pancreas responsible ... When talking about pancreatic cancers, the most common type is pancreatic adenocarcinoma, which accounts for greater than 85% ... Ryan, David P.; Hong, Theodore S.; Bardeesy, Nabeel (2014-09-11). "Pancreatic Adenocarcinoma". https://doi.org/10.1056/ ...
These findings can be precursor lesions of a primary bladder adenocarcinoma. No history of a different primary adenocarcinoma ... "Urachal Adenocarcinoma". AUAnet.org. Humphrey, Peter A.; Moch, Holger; Cubilla, Antonio L.; Ulbright, Thomas M.; Reuter, Victor ... Urachal cancer usually is an adenocarcinoma (about 90%) mostly with mucinous/colloidal histology. Other rare types include ... In addition, other diagnostic systems also for urachal carcinomas that are not adenocarcinomas have been proposed. ...
Pancreatic adenocarcinoma is the most common form of pancreatic cancer, and is cancer arising from the exocrine digestive part ... Pancreatic adenocarcinoma typically has poor outcomes with the average percentage alive for at least one and five years after ... Pancreatic cancers, particularly the most common type, pancreatic adenocarcinoma, remain very difficult to treat, and are ... "Pancreatic adenocarcinoma". The New England Journal of Medicine. 371 (11): 1039-49. doi:10.1056/NEJMra1404198. PMID 25207767. " ...
Mäkinen MJ (January 2007). "Colorectal serrated adenocarcinoma". Histopathology. 50 (1): 131-50. doi:10.1111/j.1365-2559.2006. ...
... s are about 90% adenocarcinomas. Histologically, there are two major types of gastric adenocarcinoma (Lauren ... Adenocarcinoma of the stomach and intestinal metaplasia. H&E stain. If cancer cells are found in the tissue sample, the next ... Adenocarcinomas tend to aggressively invade the gastric wall, infiltrating the muscularis mucosae, the submucosa and then the ... Obesity is a physical risk factor that has been found to increase the risk of gastric adenocarcinoma by contributing to the ...
Adenocarcinomas account for about 40% of lung cancers. Historically, adenocarcinoma was more often seen peripherally in the ... Adenocarcinoma of the lung is currently the most common type of lung cancer in "never smokers" (lifelong nonsmokers). ... Lung cancer in people who have never smoked is almost universally NSCLC, with a sizeable majority being adenocarcinoma. On ... People with these mutations are more likely to have adenocarcinoma histology and be nonsmokers or light smokers. These people ...
Clear-cell adenocarcinoma - Type of adenocarcinoma that shows clear cells Fetal adenocarcinoma - Rare subtype of pulmonary ... Media related to Adenocarcinomas at Wikimedia Commons "Adenocarcinoma"-NCI Dictionary of Cancer Terms Surgical Videos, Images ... Several of the most common forms of cancer are adenocarcinomas, and the various sorts of adenocarcinoma vary greatly in all ... Adenocarcinoma (/ˌædɪnoʊkɑːrsɪˈnoʊmə/; plural adenocarcinomas or adenocarcinomata /ˌædɪnoʊkɑːrsɪˈnoʊmɪtə/) (AC) is a type of ...
This 52-year-old patient presented with new onset hematuria almost 2 years after diagnosis of pancreatic carcinoma. What did CT scan reveal?
Adenocarcinoma usually develops on the outer boundaries of the lungs and is more commonly found in women than in men. ... Adenocarcinoma usually develops on the outer boundaries of the lungs and is more commonly found in women than in men. ...
Ideational apraxia is reported only by a few people with Adenocarcinoma. Find out who they are, other conditions they have and ... Adenocarcinoma and Ideational apraxia. Summary:. Ideational apraxia is reported only by a few people with Adenocarcinoma. ... What is Adenocarcinoma?. Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue) is found to be ... Number of Ideational apraxia in Adenocarcinoma reports submitted per year:. Gender of people who have Adenocarcinoma and ...
Targeting Polymerase θ impairs tumorigenesis and enhances radiosensitivity in lung adenocarcinoma.. Jan 16, 2023 ... Genetic knockdown of POLQ or pharmacological inhibition by NVB decreased radioresistance in lung adenocarcinoma while causing ...
CLINICAL RELEVANCE In birds, pancreatic adenocarcinoma is rarely reported but should be considered a differential diagnosis for ... Necropsy results confirmed exocrine pancreatic adenocarcinoma, with disseminated metastases in the liver, gastrointestinal ... Pancreatic adenocarcinoma in a mynah bird. Mod Vet Pract 1982;63:573-574. ... Poorly differentiated pancreatic adenocarcinoma in a chicken. Vet Rec 1995;137:408. ...
WHO guidelines for treatment of cervical intraepithelial neoplasia 2-3 and adenocarcinoma in situ: cryotherapy, large loop ...
Reflux-promoting drugs may raise risk for esophageal adenocarcinoma. ... Esophageal adenocarcinoma. Reflux-promoting drugs may raise risk for esophageal adenocarcinoma.. The Scientist Staff. Aug 2, ... The study included 189 subjects with esophageal adenocarcinoma, 262 with adenocarcinoma of the gastric cardia, 167 with ... An increase in the incidence of esophageal adenocarcinoma was first reported in the 1970s, a time period during which drugs ...
An adenocarcinoma of the stomach arising from the parietal cells. It is characterized by the presence of malignant cells with ... Gastric Parietal Cell Adenocarcinoma. Known as: Parietal Cell Adenocarcinoma An adenocarcinoma of the stomach arising from the ... We report 10 cases of an unusual type of gastric adenocarcinoma that occurred in elderly patients 58-81 years of age… Expand. ...
Metastatic Papillary Adenocarcinoma in a 22-Year-Old: Is Her History of Mayer-Rokitansky-K üster-Hauser Syndrome Causative or ... Adenocarcinoma News This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display ... HC-based NGS impacts treatment decisions in lung cancer patients with adenocarcinoma. (International Association for the Study ... The risk of progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) is very low among patients with ...
... pancreatic ductal adenocarcinoma is still regarded as an aggressive and life-limiting malignancy. Combination chemotherapy ... Up-to-Date Tailored Systemic Treatment in Pancreatic Ductal Adenocarcinoma. Caroline Y. K. Fong. ,1Emma Burke. ,1David ... Pancreatic ductal adenocarcinoma (PDAC) is the 14th most common malignancy worldwide, with a global incidence of 458,918 cases ... E. S. Knudsen, E. M. OReilly, J. R. Brody, and A. K. Witkiewicz, "Genetic diversity of pancreatic ductal adenocarcinoma and ...
... High Quality Pathology Images of Pulmonary: Epithelial Lung Tumors of Adenocarcinoma. ... Discontinuing the terms bronchioloalveolar carcinoma and mixed subtype adenocarcinoma; 2) Adding Adenocarcinoma-in-situ to the ... for non-invasive component in an invasive adenocarcinoma; 6) Introduction of the term invasive mucinous adenocarcinoma for ... Lung Adenocarcinoma : Molecular Genetics. Molecular Genetics of Lung AdenoCA : EGFR Mutations. Molecular Genetics of Lung ...
... J Am Geriatr Soc. 1970 May;18(5):428-30. ...
Gastroesophageal adenocarcinomas (GEA) are devastating diseases with stark global presence. Over the past 10 years, there have ...
Esophageal adenocarcinoma (EAC) has a poor 5-year survival rate and lacks robust preclinical models for use in research. Here, ... Esophageal adenocarcinoma (EAC) incidence is increasing while 5-year survival rates remain less than 15%. A lack of ... Esophageal adenocarcinoma (EAC) incidence is increasing while 5-year survival rates remain less than 15%. A lack of ... Garman, K. S., Orlando, R. C. & Chen, X. X. Experimental models for Barretts esophagus and esophageal adenocarcinoma. Am. J. ...
... dc.contributor.author. Bass, Adam J.. en_US. ... Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas ... "Comprehensive molecular characterization of gastric adenocarcinoma." Nature 513 (7517): 202-209. doi:10.1038/nature13480. http ...
Ovine pulmonary adenocarcinoma, also known as pulmonary adenomatosis or "jaagsiekte"(Griffiths et al., 2010) is a contagious ... Griffiths, D., Martineau, H., & Cousens, C. (2010). Pathology and pathogenesis of ovine pulmonary adenocarcinoma. Journal of ... The morphologic diagnosis was aneurysm of the pulmonary artery and pulmonary adenocarcinoma, with bronchopneumonia. ... whitish areas are observed corresponding to adenocarcinoma. (C) Pulmonary artery of an adult female "Churra Galega Bragançana" ...
Here, we evaluated the effects of SNCA on the occurrence and prognosis of lung adenocarcinoma (ADC). Comprehensive ... A meta-analysis of lung cancer gene expression identifies PTK7 as a survival gene in lung adenocarcinoma. Cancer Res. 2014, 74 ... In most countries, adenocarcinoma (ADC) is the most frequent histological lung cancer subtype. Owing to late diagnosis, the 5- ... Hou, S.; Han, X.; Ji, H. Squamous transition of lung adenocarcinoma and drug resistance. Trends Cancer 2016, 2, 463-466. [ ...
Should adenocarcinoma of the esophagogastric junction be classified as esophageal cancer? A comparative analysis according to ... Adenocarcinoma of the esophagogastric junction: results of surgical therapy based on anatomical/topographic classification in ... Sandler outlines the risk factors and anatomic features of EGJ and gastric adenocarcinomas and offers a detailed overview and ... Clinicopathologic comparison of Siewert type II and III adenocarcinomas of the gastroesophageal junction. World J Surg. 2006;30 ...
Blood Vessels, Cell, Cell Signaling, Medical Journals, Nerves, Pancreatic Ductal Adenocarcinoma (PDAC), R&D, Researchers, RNA, ... Adenocarcinomas, Breast Cancer, Chemotherapeutics, Generics, Metastatic non-small cell lung cancer, Pancreatic Cancer, ... Business, Collaborations, Indiana University, Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma (PDAC), Partnerships, PD-1/PD ... Pancreatic Ductal Adenocarcinoma (PDAC), Product Launches, Therapeutics Apotex Corp. announced April 12 the companys release ...
Capan-2 is a human pancreatic ductal adenocarcinoma cell line. These cells grow in adherent tissue culture and display ... Capan-2 is a human pancreatic ductal adenocarcinoma cell line. These cells grow in adherent tissue culture and display ... 1986) Morphological, biological, biochemical, and karyotypic characteristics of human pancreatic ductal adenocarcinoma Capan-2 ... Capan-2: Human Pancreatic Adenocarcinoma Cell Line (ATCC HTB-80) SK2000-049 ...
The prognosis of colon adenocarcinoma (COAD) remains poor. However, the specific and sensitive biomarkers for diagnosis and ... The prognosis of colon adenocarcinoma (COAD) remains poor. However, the specific and sensitive biomarkers for diagnosis and ... The Construction of a Nomogram to Estimate the Clinical Outcome of Colon Adenocarcinoma Patients. We used the "rms" R package ... Identification of Transcription Factor-Related Gene Signature and Risk Score Model for Colon Adenocarcinoma. Jianwei Lin†, ...
4590003 - Adenocarcinoma, metastatic. Differential Diagnosis & Pitfalls. Metastatic adenocarcinoma can come from a number of ... Metastatic adenocarcinoma Print Images (17) Contributors: Michael W. Winter MD, Carla Casulo MD. Other Resources UpToDate ... Metastatic adenocarcinoma may manifest in the brain, liver, lung, lymph nodes, bone, and even bone marrow. Treatment would ...
Inhibition of Barretts adenocarcinoma cell growth by simvastatin: invollvment of COX-2 and apoptosis-related proteins. J ... Systematic Review and Meta-analysis: Use of Statins Is Associated with a Reduced Incidence of Oesophageal Adenocarcinoma. *Tom ... Meta-analysis of pooled adjusted odds ratios for the effect of statin use on the development of oesophageal adenocarcinoma in ... Meta-analysis of pooled adjusted odds ratios for the effect of statin use on the development of oesophageal adenocarcinoma in ...
"The ongoing Phase 1 trial of CMG901 demonstrated promising anti-tumor activity in advanced gastric and GEJ adenocarcinoma ... CMG901 for the treatment of gastric cancer and gastroesophageal junction adenocarcinoma was granted the Orphan-drug Designation ... for the treatment of gastric cancer and gastroesophageal junction adenocarcinoma has been granted the Orphan-drug Designation ... with the FDA to finish the design of the global pivotal trial in Claudin 18.2-positive advanced gastric and GEJ adenocarcinoma ...
View Rat Genome Database annotations to adenocarcinoma in situ ... 1 RGD objects have been annotated to adenocarcinoma in situ ( ... An association has been curated linking Fancf and adenocarcinoma in situ in Chinchilla lanigera. *The association was inferred ...
The authors report a rare case of diaphragmmatic metastasis from a primary adenocarcinoma of the lung in a 76-year-old female ... Diagnosis of adenocarcinoma with diaphragmatic metastasis was then admitted and the patient started chemotherapy with ... Biopsy of the mass was performed whose histological examination was consistent with moderately differentiated adenocarcinoma. ... The authors report a rare case of diaphragmmatic metastasis from a primary adenocarcinoma of the lung in a 76-year-old female ...
Difference Between Carcinoma and Adenocarcinoma Carcinoma vs Adenocarcinoma The word cancer is one thing that most patients are ... Email a copy of Difference Between Carcinoma and Adenocarcinoma to a friend ...
... male diagnosed in late February of this year with Stage IV adenocarcinoma with cells of the Signet Ring Type. ... I, too, have adenocarcinoma of the signet cell type - very aggressive and fast-moving. Fortunately, mine was caught in stage 3B ... I, too, have adenocarcinoma of the signet cell type - very aggressive and fast-moving. Fortunately, mine was caught in stage 3B ... I am a 48 y.o. male diagnosed in late February of this year with Stage IV adenocarcinoma with cells of the Signet Ring Type. ...
Outcomes in Patients with Metastatic Pancreatic Adenocarcinoma When Administering MRI-Guided Adaptive Radiation Therapy (MRgART ... Outcomes in Patients with Metastatic Pancreatic Adenocarcinoma When Administering MRI-Guided Adaptive Radiation Therapy ...
  • There are two main histological subtypes, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), the latter has become the dominant subtype in western countries over the past 30 years with a marked increase in tumors occurring around the gastro-esophageal junction. (nature.com)
  • For adenocarcinomas (tumors originating in glandular structures of epithelial tissue such as prostate, pancreatic, and colorectal cancers), the differentiability of glandular architecture in histopathology images is one of the key criteria used by pathologists to determine the presence and degree of malignancy (Figure 1). (kitware.com)
  • To investigate the genetic events associated with their development and clinicopathologic features, we analyzed the alterations in K-ras, APC, beta-catenin, hMLH1 and hMSH2 and p53 genes expression in a cohort of 15 primary tumors comprising the two main sinonasal adenocarcinoma subtypes (enteric and seromucinous). (duke.edu)
  • Meanwhile, CDA was defined as an adenocarcinoma that is characterized by tumors having tubular or papillary formations (i.e. (researchsquare.com)
  • The study looks specifically at the relationship between pancreatic ductal adenocarcinoma cancer tumors and dense tissue growth. (labroots.com)
  • Nine of the tumors were well-differentiated, adenoacanthomas (six) or adenocarcinomas (three) and limited to the endometrium. (qxmd.com)
  • All patients with advanced adenocarcinoma should have their tumors tested for genetic mutations such as EGFR , ALK , ROS1 , and BRAF . (cancer.net)
  • Of the 50 asbestos related cancers, 11 were adenocarcinomas, 6 were anaplastic large cell tumors, 8 showed a combination of cell types, and 3 were unclassified. (cdc.gov)
  • QSOX1 is overexpressed in prostate cancers and in pancreatic adenocarcinoma. (inserm.fr)
  • The study included 189 subjects with esophageal adenocarcinoma, 262 with adenocarcinoma of the gastric cardia, 167 with esophageal squamous cell carcinoma, and 820 control subjects. (the-scientist.com)
  • In contrast, no association was noted for adenocarcinoma of the gastric cardia or esophageal squamous cell carcinoma. (the-scientist.com)
  • Oncocytic adenocarcinoma of the stomach: parietal cell carcinoma. (semanticscholar.org)
  • The two most common histological subtypes, squamous cell carcinoma (OSC) and adenocarcinoma (OAC), together make up approximately 98% of this number. (springer.com)
  • Adenocarcinoma and squamous cell carcinoma are different diseases, but both are diagnosed in advanced stages in Brazil, compromising the patients' possibilities of cure. (scielo.br)
  • Idade média ao diagnóstico foi de 60 anos para adenocarcinoma (EA) e 62 para carcinoma epidermóide e o tempo médio entre início dos sintomas até o diagnóstico foi de 3,52 meses para adenocarcinoma e 4,2 para carcinoma epidermóide. (scielo.br)
  • O tempo médio para iniciar tratamento foi de 4 meses para adenocarcinoma e 4,42 meses para carcinoma epidermóide. (scielo.br)
  • According to the World Health Organization (WHO) classification [2], GC comprises five main adenocarcinoma types, including papillary adenocarcinoma, tubular adenocarcinoma, mucinous adenocarcinoma, poorly cohesive carcinoma and mixed adenocarcinoma, as well as other rare entities. (researchsquare.com)
  • In this population-based study of United States cancer registry data from 1999 to 2017, rates of getting both squamous cell carcinoma and adenocarcinoma cervical cancer dropped. (cdc.gov)
  • A review of 118 adenocarcinomas revealed that the biliopancreatic type had a worse prognosis while the intestinal type may behave more like duodenal carcinoma. (medscape.com)
  • Histologically, NSCLC is divided into adenocarcinoma, squamous cell carcinoma (SCC) (see the image below), and large cell carcinoma. (medscape.com)
  • Agregado heterogéneo de al menos tres tipos histológicos diferentes de cáncer de pulmón, como el CARCINOMA DE CÉLULAS ESCAMOSAS, el ADENOCARCINOMA y el CARCINOMA DE CÉLULAS GRANDES. (bvsalud.org)
  • Genetic knockdown of POLQ or pharmacological inhibition by NVB decreased radioresistance in lung adenocarcinoma while causing little toxicity to normal pulmonary epithelial cells. (physiciansweekly.com)
  • This report describes a case of an adult female sheep of the "Churra Galega Bragançana" breed with an aneurysm of the pulmonary artery associated with lung cancer (ovine pulmonary adenocarcinoma). (scielo.cl)
  • Lung adenocarcinoma, which is a typical form of non-small cell lung cancer (NSCLC), accounts for a high proportion of lung cancer cases, and the majority of primary pulmonary adenocarcinomas are highly heterogeneous ( 4 ). (spandidos-publications.com)
  • Ovine pulmonary adenocarcinoma is a pulmonary neoplasm due to an infectious virus that causes progressive respiratory distress and weight loss. (msdvetmanual.com)
  • Ovine pulmonary adenocarcinoma (OPA) is an infectious, viral, neoplastic disease of the lungs of sheep and, rarely, of goats. (msdvetmanual.com)
  • An association has been curated linking Fancf and adenocarcinoma in situ in Chinchilla lanigera. (mcw.edu)
  • Studying mouse models, we demonstrate that Rb1 loss facilitates lineage plasticity and metastasis of prostate adenocarcinoma initiated by Pten mutation. (medworm.com)
  • The authors report a rare case of diaphragmmatic metastasis from a primary adenocarcinoma of the lung in a 76-year-old female patient with no history of active or passive smoking with progressive worsening fatigue, asthenia, malaise, and unquantified weight loss with three months of evolution, associated with pleuritic chest pain and edema of the lower limbs for fifteen days previous to hospital admission. (scirp.org)
  • Diagnosis of adenocarcinoma with diaphragmatic metastasis was then admitted and the patient started chemotherapy with carboplatin and gemcitabine. (scirp.org)
  • It was on July 8, 2010 when I was diagnosed with Stage 4 Adenocarcinoma of the Lung, with metastasis to the spine, lymph nodes, and 42 lesions in the brain. (burzynskipatientgroup.org)
  • Sinonasal adenocarcinomas, a relatively rare entity, are composed of distinctly different morphologic subtypes with variable biological behavior. (duke.edu)
  • Our results show that (1) a subset of enteric-type sinonasal adenocarcinoma shares certain genetic alterations with colonic adenocarcinomas, (2) the seromucinous-type sinonasal adenocarcinoma lacks alterations and may develop through a different pathway, (3) high p53 expression is associated with aggressive tumor features in both subtypes and (4) the enteric-type runs a more malignant course than the seromucinous counterpart. (duke.edu)
  • Studies examining adenocarcinoma development in Barrett's oesophagus included 1057 cancers and 17,741 controls. (springer.com)
  • There is a site for these relatively rare abdominal cancers called PMPPals that has lots of reference information on the varvious adenocarcinomas. (cancer.org)
  • Lung adenocarcinoma accounts for a high proportion of lung cancers. (spandidos-publications.com)
  • There was a clear association between squamous cell cancer and head and neck cancers, as well as certain habits, such as smoking and alcoholism, while adenocarcinoma cancer showed more association with gastric cancer and gastroesophageal reflux disease. (scielo.br)
  • So while only a few prostate cancers are diagnosed originally as neuroendocrine prostate cancer, many cases that develop after adenocarcinoma has evolved into neuroendocrine prostate cancer go undetected. (lww.com)
  • Summary of first- and second-line trials in metastatic pancreatic ductal adenocarcinoma. (hindawi.com)
  • Metastatic adenocarcinoma can come from a number of sites including lung , pancreas , colon , and prostate . (logicalimages.com)
  • In case of differential diagnosis between metastatic adenocarcinoma pleural and primary mesothelioma is recommended to include this antibody to immunohistochemical panel, because the positive immunostaining for CA 72.4 strongly suggests the first possibility and the second if is negative. (anacrom.com)
  • Polymorphous low-grade adenocarcinoma (PLGA) is a malignant tumor which occurs predominantly in minor salivary glands and exhibits low tendency for aggressive behavior and metastatic spread. (bvsalud.org)
  • Differentiability and topological characteristics of the glandular structures is one of the key factors in the diagnosis and grading of adenocarcinomas through histology images. (kitware.com)
  • In this blog post, we present a deep learning approach for encoding the glandular epithelium architecture based on a recently developed vectorized persistent homology representation called persistence images and demonstrate its application to automated diagnosis of colorectal adenocarcinomas with very encouraging results. (kitware.com)
  • With the aim of improving the diagnosis and treatment of lung adenocarcinomas, in the present study, data mining of the public Gene Expression Omnibus (GEO) database and bioinformatics analysis was performed to identify differentially expressed protein-coding genes between lung cancer and normal tissue samples. (spandidos-publications.com)
  • A total of 810 prostatic needle core biopsy specimens obtained from 100 patients with suspected prostatic adenocarcinoma were retrieved from the archival material at King Khalid University Hospital, Riyadh, and classified independently by 3 experienced histopathologists who were blinded to the original diagnosis. (who.int)
  • Average age at diagnosis was 60.66 years old for esophageal adenocarcinoma and 62 for squamous cell cancer, average time from the beginning of symptoms to the diagnosis was 3.52 months for esophageal adenocarcinoma and 4.2 months for squamous cell cancer. (scielo.br)
  • 8) Discontinuing the term mucinous cystadenocarcinoma and including them in colloid adenocarcinoma. (webpathology.com)
  • CHENGDU, China , April 12, 2022 /PRNewswire/ -- Keymed Biosciences (2162.HK) announced that its new drug candidate CMG901 (the "Claudin 18.2 antibody drug conjugates") for the treatment of gastric cancer and gastroesophageal junction adenocarcinoma has been granted the Orphan-drug Designation by the Food and Drug Administration of the United States (the "FDA") recently. (prnewswire.com)
  • Histologically, 84 percent are squamous cell carcinomas and about 3 percent are adenocarcinomas, the latter especially in the salivary glands. (krebsdaten.de)
  • In patients with Barrett's oesophagus, statin use was associated with a reduced incidence of adenocarcinoma (pooled adjusted odds ratio (OR) 0.59 (95% confidence intervals 0.50-0.68)), with no heterogeneity between 11 studies. (springer.com)
  • PURPOSE: This phase II trial is studying how well giving vaccine therapy together with adjuvant chemoradiotherapy works in treating patients with resected stage I or stage II adenocarcinoma (cancer) of the pancreas. (clinicaltrials.gov)
  • Determine overall and disease-free survival of patients with resected stage I or II adenocarcinoma of the pancreas treated with adjuvant chemoradiotherapy in combination with GVAX pancreatic cancer vaccine. (clinicaltrials.gov)
  • Survival analysis performed using Kaplan‑Meier curves and Cox regression indicated that these four genes were all significantly associated with the survival of patients with lung adenocarcinomas. (spandidos-publications.com)
  • Evaluate the nutritional state of patients with a total or partial gastrectomy due to gastric adenocarcinoma. (scielo.org.pe)
  • Descriptive study with a transversal cut, which included 14 patients with gastrectomy due to gastric adenocarcinoma, with a minimun evolution time of five months since the gastrectomy was performed. (scielo.org.pe)
  • Avani Athauda, MBBS, MRCP, The Royal Marsden NHS Foundation Trust, London, UK, presents results of an interim safety analysis of 15 patients from the ongoing ICONIC study (NCT03399071), a single-arm Phase II trial investigating the safety and efficacy of periperative FLOT in combination with avelumab, an anti-PD-L1 antibody in patients with resectable esophagogastric adenocarcinoma. (vjoncology.com)
  • Researchers developed a machine learning model that may identify patients at high risk of lung adenocarcinoma (LUAD) recurrence. (cancernursingtoday.com)
  • Twenty-seven patients with adenocarcinoma of the prostate, and available partners, were interviewed to qualitatively and quantitatively assess their level of sexual function prior to and 12 months after radiotherapy. (elsevier.com)
  • Pembrolizumab in Combination with Neoadjuvant Chemoradiotherapy for Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction. (mayo.edu)
  • That month, Pfizer said it had halted enrollment of new patients in a trial that was testing that whether the drug could be used as a first-line treatment in patients with non-adenocarcinoma, nonsmall-cell lung cancer. (wsj.com)
  • Furthermore, another review found that 21 of 24 cases due to candida occurred in patients who had undergone thoracic surgery (3), and most cases of gastropericardial fistula occurred in patients with gastric adenocarcinoma (2). (medpagetoday.com)
  • Colonic dysplasia is a precursor to adenocarcinoma and occurs in patients with UC. (medscape.com)
  • Historically, patients with UC had a 1% risk of colon adenocarcinoma per year after 8-10 years of disease. (medscape.com)
  • I'm sure it is on other pages, but non-smokers can also get lung cancer, Adenocarcinoma being the most common. (cdc.gov)
  • This retrospective study aimed to assess the concordance and interobserver variation between histopathologists in reporting prostatic adenocarcinoma using material obtained from prostatic core biopsy specimens. (who.int)
  • K/C/O Prostatic adenocarcinoma, Sigmoid colostomy status. (radiopaedia.org)
  • This is a biopsy proven case of prostatic adenocarcinoma with extensive metastases (local and distant). (radiopaedia.org)
  • Prostatic adenocarcinoma is by far the commonest histological type. (radiopaedia.org)
  • Faisal M, Tariq H. Retracted: Histopathological Correlation Between Prostatic Adenocarcinoma in Transrectal Ultrasound Guided Biopsies and Radical Prostatectomy Specimens. (sfu.ca)
  • In human prostatic adenocarcinomas, CA 72.4 expression negatively correlates with the Gleason grade of differentiation. (anacrom.com)
  • Total proctocolectomy is often curative, alleviating symptoms and removing the risk of colonic adenocarcinoma. (medscape.com)
  • Clonal status and clinicopathological observation of cervical minimal deviation adenocarcinoma. (humpath.com)
  • Endocervical Adenocarcinomas With Prominent Endometrial or Endomyometrial Involvement Simulating Primary Endometrial Carcinomas: Utility of HPV DNA Detection and Immunohistochemical Expression of p16 and Hormone Receptors to Confirm the Cervical Origin of the Cor pus Tumor. (humpath.com)
  • The rate of getting adenocarcinoma cervical cancer dropped from 1999 to 2017 for all age groups. (cdc.gov)
  • The molecular signatures of lung adenocarcinoma (LUAD) are not well understood. (medsci.org)
  • COX6B2 is expressed in human lung adenocarcinoma (LUAD) and expression correlates with reduced survival time. (elifesciences.org)
  • Lung adenocarcinoma (LUAD) is the most prevalent thoracic cancer with the highest incidence and mortality worldwide. (jcancer.org)
  • Biopsy of the mass was performed whose histological examination was consistent with moderately differentiated adenocarcinoma. (scirp.org)
  • The most common histopathological subtype is tubular adenocarcinoma, which can be subclassified into two grades of well- or moderately-differentiated adenocarcinoma [2]. (researchsquare.com)
  • One of the GGOs which was resected in another hospital had been confirmed to be EGFR mutation -positive lung adenocarcinoma . (bvsalud.org)
  • Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue) is found to be associated with 835 drugs and 427 conditions by eHealthMe. (ehealthme.com)
  • Background: Crawling-type adenocarcinoma (CRA) is an important gastric cancer (GC) subtype that exhibits a specific histological pattern and has characteristic clinicopathological findings. (researchsquare.com)
  • Crawling-type adenocarcinoma (CRA) is an important subtype among moderately-differentiated adenocarcinomas and has attracted increased attention as a specific histological GC subtype due to its characteristic clinicopathological and molecular findings [3-6]. (researchsquare.com)
  • Identification of novel DNA hypermethylation of the adenylate kinase 5 promoter in colorectal adenocarcinoma. (nih.gov)
  • Pancreatic ductal adenocarcinoma (PDAC) is the 14th most common malignancy worldwide, with a global incidence of 458,918 cases in 2018 [ 1 ]. (hindawi.com)
  • Pancreatic ductal adenocarcinoma, known by its acronym PDAC, has a five-year survival rate of less than 10%, making it the most fatal pancreatic cancer. (labroots.com)
  • The present study aimed to detect differentially expressed protein‑coding genes to identify novel biomarkers and therapeutic targets for lung adenocarcinoma. (spandidos-publications.com)
  • In conclusion, TOP2A, CDC20, BUB1 and MAD2L1 may be key protein‑coding genes that may serve as biomarkers and therapeutic targets in lung adenocarcinomas. (spandidos-publications.com)
  • The results indicated that DNA topoisomerase 2α (TOP2A), cell division cycle protein 20 homolog (CDC20), mitotic checkpoint serine/threonine kinase BUB1 (BUB1) and mitotic spindle assembly checkpoint MAD2A (MAD2L1) may be potential biomarkers and therapeutic targets in lung adenocarcinomas. (spandidos-publications.com)
  • Prognostic-Related Biomarkers in Pancreatic Ductal Adenocarcinoma Correlating with Immune Infiltrates Based. (medscimonit.com)
  • Review of the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute indicates adenocarcinoma is the most frequently identified histology for ampullary cancer. (medscape.com)
  • However, surveillance colonoscopy must be undertaken with caution, because even low-grade dysplasia is associated with synchronous adenocarcinoma in as many as 42% of cases, and as many as 84% of neoplasms in persons with UC are missed at random biopsy. (medscape.com)
  • The prognosis of colon adenocarcinoma (COAD) remains poor. (frontiersin.org)
  • And while it rarely arises de novo, the amount of neuroendocrine differentiation of prostate adenocarcinoma increases with disease progression and in response to androgen-deprivation therapy. (lww.com)
  • Pancreatic carcinogenesis results from a stepwise progression in which accumulating genetic alterations drive neoplastic progression in well-defined precursor lesions, ultimately giving rise to an invasive adenocarcinoma. (elsevier.com)
  • BIRC5 promotes lung adenocarcinoma progression by modulating PD-L1 expression and inducing tumor immune evasion. (jcancer.org)
  • Although very rare, some of EGFR mutated lung adenocarcinoma might have a very slow progression. (bvsalud.org)
  • In a new paper published this week in Cancer Cell, Mayo Clinic researchers provide genetic evidence that Ect2 drives lung adenocarcinoma tumor formation. (medworm.com)
  • A total of 303 DEGs were identified in lung adenocarcinomas, and they were enriched in a number of cancer‑associated GO terms and KEGG pathways. (spandidos-publications.com)
  • Gastric adenocarcinoma is still one of the most frequent causes of mortality due to cancer in the world. (scielo.org.pe)
  • Average time for initiating treatment when esophageal cancer is diagnosed was 4 months for esophageal adenocarcinoma and 4.42 months for squamous cell cancer. (scielo.br)
  • This aggressive subtype of prostate cancer, with survival of approximately one year, most commonly evolves from preexisting prostate adenocarcinoma, she continued. (lww.com)
  • Published in 1971, Adenocarcinoma of the Vagina: Association of Maternal Stilbestrol Therapy with Tumor Appearance in Young Women, by Arthurs L. Herbst and colleagues, was the first piece of literature connecting maternal use of the drug diethylstilbestrol (DES), also called stilbestrol, with the development of a rare and severe form of vaginal cancer in young women. (asu.edu)
  • 7] However, data acquired after the advent of improved medical therapy suggested that the incidence of adenocarcinoma had decreased somewhat. (medscape.com)
  • ASCRS U , www.ascrsu.com/ascrs/view/ASCRS-Toolkit/2851072/all/Laparoscopic_Total_Proctocolectomy_for_Familial_Adenomatous_Polyposis_with_Lower_Rectal_Adenocarcinoma. (ascrsu.com)
  • We report a rare case of primary adenocarcinoma of the renal pelvis and ureter in an incomplete duplicated ureter. (unboundmedicine.com)
  • This case is thought to be the first report of primary adenocarcinoma of the renal pelvis in an incomplete duplicated ureter. (unboundmedicine.com)
  • Acta urologica Japonica JO - Hinyokika Kiyo VL - 42 IS - 4 N2 - We report a rare case of primary adenocarcinoma of the renal pelvis and ureter in an incomplete duplicated ureter. (unboundmedicine.com)
  • Invasive Endocervical Adenocarcinoma: A New Pattern-based Classification System With Important Clinical Significance. (humpath.com)
  • mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice. (cdc.gov)
  • This study determined global mRNA and miRNA profiles in whole blood from mice exposed by inhalation to MWCNT that correlated with the presence of lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma. (cdc.gov)
  • However, critical molecular targets for lung adenocarcinomas have yet to be identified. (spandidos-publications.com)
  • In this study we compared the clinicopathologic and molecular features of CRA with those for conventional differentiated adenocarcinoma (CDA). (researchsquare.com)