Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Lung Neoplasms: Tumors or cancer of the LUNG.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Barrett Esophagus: A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Adenocarcinoma, Bronchiolo-Alveolar: A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)Stomach Neoplasms: Tumors or cancer of the STOMACH.Cardia: That part of the STOMACH close to the opening from ESOPHAGUS into the stomach (cardiac orifice), the ESOPHAGOGASTRIC JUNCTION. The cardia is so named because of its closeness to the HEART. Cardia is characterized by the lack of acid-forming cells (GASTRIC PARIETAL CELLS).Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Colonic Neoplasms: Tumors or cancer of the COLON.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Esophagogastric Junction: The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Keratin-7: A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Cell Line, Tumor: A cell line derived from cultured tumor cells.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Carcinoma, Signet Ring Cell: A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Cecal Neoplasms: Tumors or cancer of the CECUM.Mammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Adenocarcinoma, Clear Cell: An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)Metaplasia: A condition in which there is a change of one adult cell type to another similar adult cell type.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Rectal Neoplasms: Tumors or cancer of the RECTUM.Ampulla of Vater: A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.Genes, ras: Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.Common Bile Duct Neoplasms: Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.Keratin-20: A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.Tissue Array Analysis: The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.Ileal Neoplasms: Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).Adenoma: A benign epithelial tumor with a glandular organization.Pancreaticoduodenectomy: The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.DNA, Neoplasm: DNA present in neoplastic tissue.Jejunal Neoplasms: Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Carcinoma, Adenosquamous: A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Carcinoma, Acinar Cell: A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Esophagus: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Gastrectomy: Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Paranasal Sinus Neoplasms: Tumors or cancer of the PARANASAL SINUSES.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Carcinoma in Situ: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.Receptor, Epidermal Growth Factor: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Pancreatectomy: Surgical removal of the pancreas. (Dorland, 28th ed)Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Mucins: High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.Gastrointestinal Neoplasms: Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Appendiceal Neoplasms: Tumors or cancer of the APPENDIX.Pancreatic Ducts: Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Gallbladder Neoplasms: Tumors or cancer of the gallbladder.DeoxycytidineSigmoid Neoplasms: Tumors or cancer of the SIGMOID COLON.Esophagectomy: Excision of part (partial) or all (total) of the esophagus. (Dorland, 28th ed)Endometrial Hyperplasia: Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissue. There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Prostatic Intraepithelial Neoplasia: A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.ras Proteins: Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.Carcinoma, Large Cell: A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.CA-19-9 Antigen: Sialylated Lewis blood group carbohydrate antigen found in many adenocarcinomas of the digestive tract, especially pancreatic tumors.Uterine Neoplasms: Tumors or cancer of the UTERUS.Mammary Neoplasms, Animal: Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).Mucin-2: A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Adenoma, Villous: An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Pancreas: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Transplantation, Heterologous: Transplantation between animals of different species.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Carcinoma, Neuroendocrine: A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)Mucin-1: Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.Loss of Heterozygosity: The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.RNA, Neoplasm: RNA present in neoplastic tissue.Cystadenocarcinoma: A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Esophagoscopy: Endoscopic examination, therapy or surgery of the esophagus.Genes, erbB-1: The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.Mesothelioma: A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Biopsy, Needle: Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Anal Sacs: A pair of anal glands or sacs, located on either side of the ANUS, that produce and store a dark, foul-smelling fluid in carnivorous animals such as MEPHITIDAE and DOGS. The expelled fluid is used as a defensive repellent (in skunks) or a material to mark territory (in dogs).QuinazolinesCystadenocarcinoma, Serous: A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Neoplasms, Unknown Primary: Metastases in which the tissue of origin is unknown.Smoking: Inhaling and exhaling the smoke of burning TOBACCO.Ki-67 Antigen: A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.Cyclooxygenase 2: An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Antigens, Tumor-Associated, Carbohydrate: Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.HT29 Cells: Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.Pleural Effusion, Malignant: Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.Mucin-4: A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Hysterectomy: Excision of the uterus.Gene Amplification: A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.beta Catenin: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Urachus: An embryonic structure originating from the ALLANTOIS. It is a canal connecting the fetal URINARY BLADDER and the UMBILICUS. It is normally converted into a fibrous cord postnatally. When the canal fails to be filled and remains open (patent urachus), urine leaks through the umbilicus.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Liver Neoplasms: Tumors or cancer of the LIVER.Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Pancreatitis, Chronic: INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.Neoplasms, Complex and Mixed: Neoplasms composed of more than one type of neoplastic tissue.Cystadenocarcinoma, Mucinous: A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)Nose Neoplasms: Tumors or cancer of the NOSE.Neoplasm Grading: Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Carcinoid Tumor: A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)DNA Methylation: Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Jaagsiekte sheep retrovirus: A BETARETROVIRUS that causes pulmonary adenomatosis in sheep (PULMONARY ADENOMATOSIS, OVINE).Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Digestive System Neoplasms: Tumors or cancer of the DIGESTIVE SYSTEM.Genes, Tumor Suppressor: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Nitrosamines: A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Genes, p53: Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.Carcinosarcoma: A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Smad4 Protein: A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Vaginal Neoplasms: Tumors or cancer of the VAGINA.Neoadjuvant Therapy: Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.Pulmonary Adenomatosis, Ovine: A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Histocytochemistry: Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Rats, Inbred F344Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Duodenogastric Reflux: Retrograde flow of duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the STOMACH.
(1/18479) Stimulation of thymidine uptake and cell proliferation in mouse embryo fibroblasts by conditioned medium from mammary cells in culture.

Undialyzed conditioned medium from several cell culture sources did not stimulate thymidine incorporation or cell overgrowth in quiescent, density-inhibited mouse embryo fibroblast cells. However, dialyzed conditioned medium (DCM) from clonal mouse mammary cell lines MCG-V14, MCG-T14, MCG-T10; HeLa cells; primary mouse adenocarcinoma cells; and BALB/c normal mouse mammary epithelial cells promoted growth in quiescent fibroblasts. The amount of growth-promoting activity produced per cell varied from 24% (HeLa) to 213% (MCG-V14) of the activity produced by primary tumor cells. The production of growth-promoting activity was not unique to tumor-derived cells or cells of high tumorigenicity. The amount of growth-promoting activity produced per cell in the active cultures was not correlated with any of the following: tumorigenicity, growth rat, cell density achieved at saturation, cell type, or species of cell origin. It is concluded that transformed and non-transformed cells of diverse origin, cell type, and tumorigenicity can produce growth factors in culture. The growth-promoting potential of the active media from primary tumor cultures accumulated with time of contact with cells and was too great to be accounted for entirely by the removal of low-molecular-weight inhibitors by dialysis. The results are consistent with the hypothesis that conditioned medium from the active cultures contained a dialyzable, growth-promoting activity. Different cell lines exhibited differential sensitivity to tumor cell DCM and fetal bovine serum. Furthermore, quiescent fibroblasts were stimulated by primary tumor cell DCM in the presence of saturating concentrations of fetal bovine serum. These observations support the notion that the active growth-promoting principle in primary tumor cell DCM may not be a serum factor(s).  (+info)

(2/18479) Classification of human colorectal adenocarcinoma cell lines.

Eleven human colorectal adenocarcinoma cell lines established in this laboratory were classified into three groups based on morphological features (light and electron microscopy), modal chromosome number, and ability to synthesize carcinoembryonic antigen (CEA). Group 1 cell lines contained both dedifferentiated and differentiating cells growing in tight clusters or islands of epithelium-like cells; their modal chromosome number was about 47, and they synthesized small to moderate amounts of CEA. Group 2 cell lines were more dedifferentiated, were hyperdiploid, and synthesized small amounts of CEA. Group 3 cell lines were morphologically similar to those of Group 1 by light microscopy. They differed ultrastructurally by containing microvesicular bodies; the modal chromosome number varied from hyperdiploid to hypertriploid or they had bimodal populations of hypodiploid and hypertriploid cells, and they synthesized relatively large amounts of CEA. No correlation could be found between Broder's grade or Duke's classification of the original tumor and modal chromosome number or ability to synthesize CEA. These findings support Nowell's hypothesis that the stem line is different for each solid tumor, which makes it difficult to relate chromosomal changes to the initiation of the neoplastic state.  (+info)

(3/18479) Expression of Bcl-2 protein is decreased in colorectal adenocarcinomas with microsatellite instability.

Bcl-2 is known to inhibit apoptosis and is thought to play a role in colorectal tumour development. Studies of the promoter region of bcl-2 have indicated the presence of a p53 responsive element which downregulates bcl-2 expression. Since p53 is commonly mutated in colorectal cancers, but rarely in those tumours showing microsatellite instability (MSI), the aim of this study was to examine the relationship of bcl-2 protein expression to MSI, as well as to other clinicopathological and molecular variables, in colorectal adenocarcinomas. Expression of bcl-2 was analysed by immunohistochemistry in 71 colorectal cancers which had been previously assigned to three classes depending upon their levels of MSI. MSI-high tumours demonstrated instability in three or more of six microsatellite markers tested, MSI-low tumours in one or two of six, and MSI-null in none of six. Bcl-2 expression in tumours was quantified independently by two pathologists and assigned to one of five categories, with respect to the number of cells which showed positive staining: 0, up to 5%; 1, 6-25%; 2, 26-50%; 3, 51-75%; and 4, > or =76%. Bcl-2 negative tumours were defined as those with a score of 0. Bcl-2 protein expression was tested for association with clinicopathological stage, differentiation level, tumour site, age, sex, survival, evidence of p53 inactivation and MSI level. A significant association was found between bcl-2 expression and patient survival (P = 0.012, Gehan Wilcoxon test). Further, a significant reciprocal relationship was found between bcl-2 expression and the presence of MSI (P = 0.012, Wilcoxon rank sum test). We conclude that bcl-2 expressing colorectal cancers are more likely to be MSI-null, and to be associated with improved patient survival.  (+info)

(4/18479) Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity.

We previously reported that the role of reactive oxygen intermediates (ROIs) in NF-kappaB activation by proinflammatory cytokines was cell specific. However, the sources for ROIs in various cell types are yet to be determined and might include 5-lipoxygenase (5-LOX) and NADPH oxidase. 5-LOX and 5-LOX activating protein (FLAP) are coexpressed in lymphoid cells but not in monocytic or epithelial cells. Stimulation of lymphoid cells with interleukin-1beta (IL-1beta) led to ROI production and NF-kappaB activation, which could both be blocked by antioxidants or FLAP inhibitors, confirming that 5-LOX was the source of ROIs and was required for NF-kappaB activation in these cells. IL-1beta stimulation of epithelial cells did not generate any ROIs and NF-kappaB induction was not influenced by 5-LOX inhibitors. However, reintroduction of a functional 5-LOX system in these cells allowed ROI production and 5-LOX-dependent NF-kappaB activation. In monocytic cells, IL-1beta treatment led to a production of ROIs which is independent of the 5-LOX enzyme but requires the NADPH oxidase activity. This pathway involves the Rac1 and Cdc42 GTPases, two enzymes which are not required for NF-kappaB activation by IL-1beta in epithelial cells. In conclusion, three different cell-specific pathways lead to NF-kappaB activation by IL-1beta: a pathway dependent on ROI production by 5-LOX in lymphoid cells, an ROI- and 5-LOX-independent pathway in epithelial cells, and a pathway requiring ROI production by NADPH oxidase in monocytic cells.  (+info)

(5/18479) Multiple target sites of allelic imbalance on chromosome 17 in Barrett's oesophageal cancer.

Twelve Barrett's adenocarcinomas have been analysed for the occurrence of allelic imbalance (LOH) on chromosome 17 using 41 microsatellite markers. This study provides evidence for 13 minimal regions of LOH, six on 17p and seven on 17q. Four of these centre in the vicinity of the known tumour suppressor genes (TSGs) TP53 (17p13.1), NFI (17q11.2), BRCA1 (17q21.1), and a putative TSG (17p13.3). The tumours all displayed relatively small regions of LOH (1-10 cM), and in several tumours extensive regions of LOH were detected. One tumour displayed only two very small regions of LOH; 17p11.2 and 17p13.1. The frequency of allelic imbalance has been calculated based on the LOH encompassing only one minimal region, and based on all the LOH observations. By both evaluations the highest LOH frequencies were found for regions II (p53), III (17p13.1 centromeric to p53), IV (17p12), V (17p11.2) and VII (NF1, 17q11.2). Our data supports the existence of multiple TSGs on chromosome 17 and challenges the view that p53 is the sole target of LOH on 17p in Barrett's adenocarcinoma.  (+info)

(6/18479) In vivo isolated kidney perfusion with tumour necrosis factor alpha (TNF-alpha) in tumour-bearing rats.

Isolated perfusion of the extremities with high-dose tumour necrosis factor alpha (TNF-alpha) plus melphalan leads to dramatic tumour response in patients with irresectable soft tissue sarcoma or multiple melanoma in transit metastases. We developed in vivo isolated organ perfusion models to determine whether similar tumour responses in solid organ tumours can be obtained with this regimen. Here, we describe the technique of isolated kidney perfusion. We studied the feasibility of a perfusion with TNF-alpha and assessed its anti-tumour effects in tumour models differing in tumour vasculature. The maximal tolerated dose (MTD) proved to be only 1 microg TNF-alpha. Higher doses appeared to induce renal failure and a secondary cytokine release with fatal respiratory and septic shock-like symptoms. In vitro, the combination of TNF-alpha and melphalan did not result in a synergistic growth-inhibiting effect on CC 531 colon adenocarcinoma cells, whereas an additive effect was observed on osteosarcoma ROS-1 cells. In vivo isolated kidney perfusion, with TNF-alpha alone or in combination with melphalan, did not result in a significant anti-tumour response in either tumour model in a subrenal capsule assay. We conclude that, because of the susceptibility of the kidney to perfusion with TNF-alpha, the minimal threshold concentration of TNF-alpha to exert its anti-tumour effects was not reached. The applicability of TNF-alpha in isolated kidney perfusion for human tumours seems, therefore, questionable.  (+info)

(7/18479) Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation.

Both experimental and clinical research have shown that hyperthermia (HT) gives valuable additional effects when applied in combination with radiotherapy (RT). The purpose of this study was evaluation of results in patients with recurrent breast cancer, treated at the Daniel den Hoed Cancer Center (DHCC) with reirradiation (re-RT; eight fractions of 4 Gy twice weekly) combined with HT. All 134 patients for whom such treatment was planned were included in the analysis. The complete response rate in 119 patients with macroscopic tumour was 71%. Including the 15 patients with microscopic disease, the local control rate was 73%. The median duration of local control was 32 months, and toxicity was acceptable. The complete response (CR) rate was higher, and the toxicity was less with the later developed 433-MHz HT technique compared with the 2450-MHz technique used initially. With this relatively well-tolerated treatment, palliation by local tumour control of a worthwhile duration is achieved in the majority of patients. The technique used for hyperthermia appeared to influence the achieved results. The value of HT in addition to this re-RT schedule has been confirmed by a prospective randomized trial in a similar patient group. In The Netherlands, this combined treatment is offered as standard to patients with breast cancer recurring in previously irradiated areas.  (+info)

(8/18479) Treatment of advanced pancreatic cancer with the long-acting somatostatin analogue lanreotide: in vitro and in vivo results.

Fourteen patients with metastatic pancreatic adenocarcinoma were treated with the long-acting somatostatin (SST) analogue lanreotide. No objective response was obtained, and the median survival was 4 months (range 1.8-7 months). Pancreatic cancer could not be visualized by means of SST-receptor (R) scintigraphy in our patients. In vitro data also demonstrated absence of SSTR2 expression, suggesting pancreatic cancer not to be a potential target for treatment with SST analogues.  (+info)

*  Adenocarcinoma
Media related to Adenocarcinomas at Wikimedia Commons "Adenocarcinoma"-NCI Dictionary of Cancer Terms Surgical Videos, Images ... Several of the most common forms of cancer are adenocarcinomas, and the various sorts of adenocarcinoma vary greatly in all ... Nearly 40% of lung cancers are adenocarcinoma, which usually originates in peripheral lung tissue. Most cases of adenocarcinoma ... Adenocarcinoma (/ˌædɪnoʊkɑːrsɪˈnoʊmə/; plural adenocarcinomas or adenocarcinomata /ˌædɪnoʊkɑːrsɪˈnoʊmɪtə/) is a type of ...
*  Esophageal cancer
Adenocarcinoma has been linked to effects of long-term acid reflux. Tobacco is a risk factor for both types. Both types are ... Adenocarcinomas tend to occur nearer the stomach and squamous cell carcinomas nearer the throat, but either may arise anywhere ... Adenocarcinoma arises from glandular cells present in the lower third of the esophagus, often where they have already ... Esophageal adenocarcinoma age-adjusted incidence increased in New Mexico from 1973 to 1997. This increase was found in non- ...
*  Squamous cell carcinoma
Esophageal cancer may be due to either squamous cell carcinoma (ESCC) or adenocarcinoma (EAC). SCCs tend to occur closer to the ... mouth, while adenocarcinomas occur closer to the stomach. Dysphagia (difficulty swallowing, solids worse than liquids) and ...
*  Timeline of pancreatic cancer
"The Clinical Utility of CA 19-9 in Pancreatic Adenocarcinoma: Diagnostic and Prognostic Updates". Curr. Mol. Med. 13: 340-51. ...
*  Fetal adenocarcinoma
Synonyms for FA include well differentiated fetal adenocarcinoma, high-grade fetal adenocarcinoma, pulmonary adenocarcinoma of ... Fetal adenocarcinoma (FA) of the lung is a rare subtype of pulmonary adenocarcinoma that exhibits tissue architecture and cell ... April 2008). "Fetal adenocarcinoma of the lung in a 25-year-old woman". J Thorac Oncol. 3 (4): 441-3. doi:10.1097/JTO. ... Adenocarcinomas are most often highly heterogeneous peripheral tumors, and are thought to arise from malignant transformation ...
*  Ceruminous adenocarcinoma
... is a malignant neoplasm derived from ceruminous glands of the external auditory canal. This tumor is ... The most common tumor type is ceruminous adenoid cystic carcinoma and ceruminous adenocarcinoma, NOS. Pain is the most common ... The tumors are separated into three main histologic or microscopic types: Ceruminous adenocarcinoma, NOS Ceruminous adenoid ... Synonyms have included cylindroma, ceruminoma, ceruminous adenocarcinoma, not otherwise specified (NOS), ceruminous adenoid ...
*  Acinar adenocarcinoma
In Europe, acinar adenocarcinoma may comprise the dominant architectural pattern in as many as 50-60% of all adenocarcinomas. ... Acinar adenocarcinoma is a histological subtype of gland-forming cancer that is diagnosed when cuboidal and/or columnar shaped ... Adenocarcinoma ("adeno" = "gland", "carcinoma" = cancer of epithelium) is the most common type of lung cancer in the U.S., ... Acinar adenocarcinoma of the lung is a highly lethal disease. Overall five-year survival rates approximate 16% to 22%. ...
*  Papillary adenocarcinoma
... is a histological form of lung cancer that is diagnosed when the malignant cells of the tumor form ...
*  Ovine pulmonary adenocarcinoma
... (OPA), also known as ovine pulmonary adenomatosis, or jaagsiekte, is a chronic and contagious ... OPA has been used as an animal model for human lung cancer, because OPA is histologically similar to human adenocarcinoma in ... De Las Heras, M; González, L; Sharp, JM (2003). "Pathology of ovine pulmonary adenocarcinoma". In Fan, Hung. Jaagsiekte Sheep ... York, DF; Querat, G (2002). "Chapter 1: A history of ovine pulmonary adenocarcinoma jaagsiekte and experiments leading to the ...
*  Anal sac adenocarcinoma
An anal sac adenocarcinoma is an uncommon and aggressive malignant tumor found in dogs that arises from the apocrine glandular ... Anal sac adenocarcinomas are often suspected due to location (palpable masse in anal sac) and behavior, but a biopsy and ... Mellanby R, Foale R, Friend E, Woodger N, Herrtage M, Dobson J (2002). "Anal sac adenocarcinoma in a Siamese cat". J Feline Med ... Hobson H, Brown M, Rogers K (2006). "Surgery of metastatic anal sac adenocarcinoma in five dogs". Vet Surg. 35 (3): 267-70. doi ...
*  Oesophagogastric junctional adenocarcinoma
... in contrast to the declining frequency of distal gastric adenocarcinoma. Treatment options for adenocarcinomas involving the ... Oesophagogastric junctional adenocarcinoma is a cancer of the lower part of the oesophagus, often linked to a Barrett's ... OGJ adenocarcinoma is a highly mutated and heterogeneous disease. Microsatellite instability (MSI) can be observed and ... The incidence of oesophagogastric junctional adenocarcinoma is rising rapidly in western countries, ...
*  Pulmonary enteric adenocarcinoma
... is rare subtype of pulmonary adenocarcinoma. Yousem, S. A. (2005). "Pulmonary intestinal-type ... Lin, D; Zhao, Y; Li, H; Xing, X (2013). "Pulmonary enteric adenocarcinoma with villin brush border immunoreactivity: A case ... adenocarcinoma does not show enteric differentiation by immunohistochemical study". Modern Pathology. 18 (6): 816-21. doi: ...
*  Clear-cell adenocarcinoma
... is a type of adenocarcinoma that shows clear cells. Types include: Clear-cell adenocarcinoma of the ... vagina Clear-cell ovarian carcinoma Uterine clear-cell carcinoma Clear-cell adenocarcinoma of the lung (which is a type of ...
*  Polymorphous low-grade adenocarcinoma
It forms glands, i.e. it is an adenocarcinoma. It affects the minor salivary glands in the area between the hard and the soft ... Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing malignant salivary gland ... Paleri V, Robinson M, Bradley P (April 2008). "Polymorphous low-grade adenocarcinoma of the head and neck". Curr Opin ... Arathi N, Bage AM (2009). "Polymorphous low-grade adenocarcinoma of parotid gland: a rare occurrence". Indian J Pathol ...
*  Adenocarcinoma of the lung
... adenocarcinoma of the lung Invasive adenocarcinoma Acinar predominant adenocarcinoma Papillary predominant adenocarcinoma ... Enteric adenocarcinoma of the lung Cribriform adenocarcinoma of the lung Adenocarcinoma of the lung tends to stain mucin ... Adenocarcinoma of the lung (pulmonary adenocarcinoma) is a common histological form of lung cancer that contains certain ... Micropapillary predominant adenocarcinoma Solid predominant adenocarcinoma Invasive mucinous adenocarcinoma In as many as 80% ...
*  Aggressive digital papillary adenocarcinoma
... (also known as a digital papillary adenocarcinoma and papillary adenoma) is a ...
*  Villoglandular adenocarcinoma of the cervix
... , also villoglandular papillary adenocarcinoma, papillary villoglandular ... A similar lesion, villoglandular adenocarcinoma of the endometrium, may arise from the inner lining of the uterus, the ... adenocarcinoma and well-differentiated villoglandular adenocarcinoma, abbreviated VGA, is a rare type of cervical cancer that, ... "Villoglandular papillary adenocarcinoma of the uterine cervix: a diagnostic challenge". Acta Obstet Gynecol Scand. 88 (3): 355- ...
*  Adenocarcinoma in situ of the lung
... papillary adenocarcinoma, and solid adenocarcinoma with mucin production. However, approximately 80% of adenocarcinomas are ... Atypical adenomatous hyperplasia of the lung Minimally invasive adenocarcinoma of the lung Adenocarcinoma of the lung Van Schil ... including BACs and other forms of adenocarcinoma. The Noguchi classification system for small adenocarcinomas has received ... BACs are one of four specific histologic subtypes of lung adenocarcinoma, along with acinar adenocarcinoma, ...
*  Minimally invasive adenocarcinoma of the lung
Atypical adenomatous hyperplasia of the lung Adenocarcinoma in situ of the lung Adenocarcinoma of the lung Van Schil, P. E.; ... Minimally invasive adenocarcinoma of the lung (MIA) is defined as a small (≤3 cm), solitary tumour with predominant alveolar ... "Surgical implications of the new IASLC/ATS/ERS adenocarcinoma classification". European Respiratory Journal. 39 (2): 478-86. ... epithelial appearance (lepidic growth), as in situ adenocarcinoma of the lung, with a zone of focal invasion of the chorion, ...
*  Clear-cell adenocarcinoma of the vagina
Clear-cell adenocarcinoma (CCA) of the vagina (or cervix) is a rare Adenocarcinoma (cancer) often linked to diethylstilbestrol ... Clear cell adenocarcinoma entry in the public domain NCI Dictionary of Cancer Terms DES Action USA [1] national consumer ... DES Daughters should have a special pap/pelvic exam every year because of their lifelong risk for clear-cell adenocarcinoma. ... "Higher incidence of clear cell adenocarcinoma of the cervix and vagina among women born between 1947 and 1971 in the United ...
*  DMOZ - Health: Conditions and Diseases: Cancer: Gastrointestinal: Small Intestine: Adenocarcinoma
Most common cancer that begins in the glandular cells in the lining of the small intestine.
*  Field stain
Colorectal adenocarcinoma. Field stain. Granuloma. Field stain. Chunge, CN.; Ngige, S.; Bwibo, CR.; Mulega, PC.; Kilonzo, JF.; ...
*  Pancreas
Pancreatic adenocarcinoma, which affects the exocrine part of the pancreas, is by far the most common form. The many types of ... Pancreatic adenocarcinoma typically has poor outcomes with the average percentage alive for at least one and five years after ... ISBN 978-0-7020-3085-7. Ryan DP, Hong TS, Bardeesy N (September 2014). "Pancreatic adenocarcinoma". N. Engl. J. Med. 371 (11): ... Pancreatic cancers, particularly the most common type, pancreatic adenocarcinoma, remain very difficult to treat, and are ...
*  Pancreatic cancer
Pancreatic adenocarcinoma typically has a very poor prognosis: after diagnosis, 25% of people survive one year and 5% live for ... Typically, pancreatic adenocarcinoma first spreads to nearby lymph nodes, and later to the liver or to the peritoneal cavity, ... These adenocarcinomas start within the part of the pancreas which makes digestive enzymes. Several other types of cancer, which ... Pancreatic adenocarcinoma and the other less common exocrine cancers have a very poor prognosis, as they are normally diagnosed ...
*  Sessile serrated adenoma
Mäkinen MJ (January 2007). "Colorectal serrated adenocarcinoma". Histopathology. 50 (1): 131-50. doi:10.1111/j.1365-2559.2006. ...
In the present study, we demonstrated PCV and EGFR mutation status as independent prognostic factors in untreated advanced lung adenocarcinoma patients. We also showed that PCV , 2.2 ng/ml was a predictor of a favorable outcome in both advanced lung adenocarcinoma patients with wild-type and mutant EGFR.. Serum CYFRA 21-1 has been reported as a prognostic factor in patients with a variety of cancer types, including resectable NSCLC [39, 40], biliary tract cancer [41], urothelial cancer [42], head and neck cancer [43], esophageal cancer [44], and cervical cancer [45].. A meta-analysis of CYFRA 21-1 as a prognostic indicator in advanced NSCLC patients showed that the PCV may be a reliable prognostic factor [29], however, since non-adenocarcinoma accounted for 65% of the cases and squamous cell carcinoma for 50%, the role of serum CYFRA 21-1 as a prognostic indicator in the lung adenocarcinoma population remained unclear. Moreover, in a study of PCV as a prognostic indicator in advanced NSCLC ...
Licorice and its components have been reported to posses various anti-tumor activities, but its active ingredients and underlying mechanisms are not well understood yet. In the present study, a group of representative licorice-derived compounds that could be detected in rat plasma or urine were screened for anti-tumor activity. Among these compounds, isoangustone A (IAA) was found to promptly Inhibit the viability of SW480 human colorectal adenocarcinoma cells in a time- and concentration-dependent manner. Further analyses indicate that IAA activated caspase-dependent pro-apoptotic signaling and induced significant apoptosis, while had little effect on cell cycle. IAA strongly inhibited Akt phosphorylation within 5 min; however, overexpression of constitutively activated Akt could not rescue IAA-mediated inhibition, indicating that inhibition of Akt was not involved in IAA-induced apoptosis. Further examinations show that IAA induced dissipation of mitochondria membrane potential and release of ...
Cell lines are invaluable tools for biomedical research. Cancer cell lines are the foundation of cancer biology and the quest for drug treatments. Adenocarcinoma is a cancer of the epithelium (including colon) and originates in glandular tissue, such as skin surface layer and glands.. Product. These human adenocarcinoma cell lines have been previously licensed to commercial parties for research into human adenocarcinoma treatments.. These cell lines are available through Public Health England ECACC. Please make your purchase through the links below.. Imperial Innovations requests that commercial/for profit parties contact them first to discuss the terms of supply prior to Innovations authorising the release of supplies from ECACC.. ...
BioAssay record AID 102327 submitted by ChEMBL: Cytotoxicity activity on LoVo/Dx human adenocarcinoma cell line after 1 hr of drug exposure.
Mickey, D D.; Stone, K R.; Wunderli, H; Mickey, G H.; Vollmer, R T.; and Paulson, D F., "Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice." (1977). Subject Strain Bibliography 1977. 30 ...
Adenocarcinomas metastatic to brain from lung or colon may pose differentiation difficulties. Ultrastructurally, both may have brush borders with rootlets. This study examines the ultrastructural morphology and immunohistochemical expression of villin (associated with rootlets), cytokeratin 7 (present in lung adenocarcinomas), and cytokeratin 20 (present in colon adenocarcinomas) in 19 formalin-fixed sequential surgical biopsies of lung adenocarcinomas metastatic to brain as compared to 13 colonic adenocarcinoma metastases. Of lung tumor metastases, mucinous differentiation with rootlets was most common [6/19(32%)]. All colon tumor metastases were cytokeratin 7(-), 20(+), and profusely villin(+). Well-formed rootlets were seen. All lung metastases were cytokeratin 7(+) and 20(-). 5/6(83%) lung metastases with rootlets were focally villin(+). 12/13(95%) without rootlets were villin(-). Rootlets are extremely common in lung adenocarcinoma metastatic to brain. Villin immunoreactivity closely correlates
Purpose: The microRNA-34b/c (miR-34b/c) is considered a tumor suppressor in different tumor types and a transcriptional target of TP53. The main objectives of this study were to investigate the clinical implications of miR-34b/c methylation in patients with early-stage lung adenocarcinoma and to determine the functional role of miR-34b/c re-expression in lung adenocarcinoma cell lines.. Experimental Design: Aberrant methylation and expression of miR-34b/c were assessed in 15 lung adenocarcinoma cell lines and a cohort of 140 early-stage lung adenocarcinoma. Lung adenocarcinoma cell lines were transfected with miR-34b/c and the effects upon cell proliferation, migration, invasion, and apoptosis were investigated.. Results: Aberrant methylation of miR-34b/c was detected in 6 (40%) of 15 lung adenocarcinoma cell lines and 64 of 140 (46%) primary lung adenocarcinoma. Expression of miR-34b/c was significantly reduced in all methylated cell lines and primary tumors, especially with TP53 mutations. ...
BACKGROUND/AIM AXL (anexelekto) has been explored as a potential novel therapeutic target for non-small cell lung carcinoma (NSCLC) but its activation status has not been evaluated in NSCLC. PATIENTS AND METHODS We first immunolocalized the phosphorylated form of AXL in 112 lung adenocarcinoma cases and subsequently evaluated the anti-neoplastic effects of monoclonal antibody AXL in two lung adenocarcinoma cell lines, PC9 and A549. RESULTS Phospho-AXL immunoreactivity was detected in 59.8% of adenocarcinoma cases examined and tended correlate significantly with larger tumor size (p=0.08) and with overall survival of the patients (p=0.041). Results of in vitro analysis revealed that the monoclonal antibody to AXL significantly inhibited cell proliferation of PC9 and A549, lung adenocarcinoma cell lines, which was caused by an inhibition of extracellular signal-regulated kinase (ERK) activation. CONCLUSION AXL-targeted therapy, possibly through inhibiting ERK activation of carcinoma cells, could
p21WAF1/CIP1 protein is a cyclin-dependent kinase inhibitor, discovered to be a downstream effector of p53-dependent cell cycle regulation. In order to elucidate the significance of p21 expression in lung adenocarcinomas, we performed immunohistochemical analysis of p21, p53 and Ki-67 expression in surgically resected lung adenocarcinomas. In non-neoplastic tissue, a few bronchial and bronchiolar suprabasal and ciliated cells, and a few type II alveolar cells and alveolar macrophages in the peripheral lung, were p21 positive, but the positive rate in normal lung tissue was very low (,1%). All 91 lung adenocarcinomas examined showed p21 immunoreactivity: 39 cases (42.9%) and 52 cases (57.1%) showed high and low p21 expression levels, respectively. There was no significant correlation between p21 expression and p53 expression, the loss of heterozygosity status of the p53 gene, histological grade determined by the predominant histology, lymph node metastasis, pathological stage, tumor size, smoking ...
Cell lines are invaluable tools for biomedical research. Cancer cell lines are the foundation of cancer biology and the quest for drug treatments. Adenocarcinoma is a cancer of the epithelium (including colon) and originates in glandular tissue, such as skin surface layer and glands.. Product. These human adenocarcinoma cell lines have been previously licensed to commercial parties for research into human adenocarcinoma treatments.. These cell lines are available through Public Health England ECACC. Please make your purchase through the links below.. Imperial Innovations requests that commercial/for profit parties contact them first to discuss the terms of supply prior to Innovations authorising the release of supplies from ECACC.. ...
BACKGROUND. The decline of gastric adenocarcinoma in the U. S. and the parallel decrease in the predominance of the intestinal type of gastric adenocarcinoma may reflect, in part, changes in diet over the last 60 years. Because the intestinal and diffuse types of gastric adenocarcinoma may be epidemiologically distinct, the authors hypothesized...
Adenocarcinoma[1] (/ˌædᵻnoʊkɑːrsᵻˈnoʊmə/; plural adenocarcinomas oradenocarcinomata /ˌædᵻnoʊkɑːrsᵻˈnoʊmᵻtə/) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandularorigin, glandular characteristics, or both. Adenocarcinomas are part of the larger grouping ofcarcinomas, but are also sometimes called by more precise terms omitting the word, where these exist. Thus invasive ductal carcinoma, the most common form of breast cancer, is adenocarcinoma but does not use the term in its name-however, esophageal adenocarcinoma does to distinguish it from the other common type of esophageal cancer, esophageal squamous cell carcinoma. Several of the most common forms of cancer are adenocarcinomas, and the various sorts of adenocarcinoma vary greatly in all their aspects, so that few useful generalizations can be made about them. ...
Adenocarcinoma (/ˌædɪnoʊkɑːrsɪˈnoʊmə/; plural adenocarcinomas or adenocarcinomata /ˌædɪnoʊkɑːrsɪˈnoʊmɪtə/) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandular origin, glandular characteristics, or both. Adenocarcinomas are part of the larger grouping of carcinomas, but are also sometimes called by more precise terms omitting the word, where these exist. Thus invasive ductal carcinoma, the most common form of breast cancer, is adenocarcinoma but does not use the term in its name-however, esophageal adenocarcinoma does to distinguish it from the other common type of esophageal cancer, esophageal squamous cell carcinoma. Several of the most common forms of cancer are adenocarcinomas, and the various sorts of adenocarcinoma vary greatly in all their aspects, so that few useful generalizations can be made about them. In the most specific usage (narrowest sense), the glandular origin or traits ...
Introduction: Lung adenocarcinoma has a complex variety of different hystopathologic subtypes with distinct epidemiology, pathology and prognosis. Pulmonary adenocarcinoma with enteric differentiation is a rare variant defined as a tumor with more than 50% of colorrectal-like components, immunohistochemistry (IHC) positive for at least one marker of enteric differentiation (CK20, CDX-2 or MUC2) and no evidence of other malignancies. Case Series: Patients were identified in a review of a set of adenocarcinomas, apparently originated in colon, but posteriorly accessed as lung adenocarcinomas. Median age was 57.6 years, were all Caucasian subjects and presented with metastatic disease. The median size were 6.3 cm at the time of diagnosis and all had spiculated shape forms at CT scans. Microscopic description revealed a lepidic (mucinous) adenocarcinoma in all five cases. Immunohistochemistry were positive for CK20 or CDX-2 in all these cases and was negative for CK7 in one patient. Conclusion: The use of
Several SOX genes are involved in lung development and may have functional roles within the lung. SOX9 (a transcription factor) has been shown to be involved in several types of cancer. In this lab-based study, SOX9 expression was investigated in 29 lung adenocarcinoma and 28 normal lung samples using silico data mining, quantitative reverse transcription-PCR and immunohistochemistry.. SOX9 was upregulated at both the mRNA and protein level in the majority of lung adenocarcinomas compared with normal tissue. In addition, recurrent lung adenocarcinoma tissue showed significantly higher SOX9 expression than that of a primary lesion. RNA interference technique and microarray gene expression further demonstrated that knockdown of SOX9 inhibited cell growth, downregulated CDK4 and upregulated p21. These are all important cell cycle regulators and their expression could mediate SOX9-related alteration in cancer cell growth.. SOX9 may be an important biomarker in lung adenocarcinoma which could aid in ...
Adenocarcinoma in situ, minimally invasive adenocarcinoma and invasive adenocarcinoma of the lung are relatively new classification entities which replace the now-defunct term bronchoalveolar carcinoma (BAC). In 2011 the International Associatio...
Background: Tumor budding has recently been reported as an independent adverse prognostic factor for colorectal adenocarcinomas and other types of carcinoma in the digestive tract. This study aimed to evaluate the prognostic value of tumor budding in patients with early-stage cervical adenocarcinomas and any associations with other clinical and pathological features. Methods: Histological slides of patients with early-stage (IB-IIA) usual-type endocervical adenocarcinoma who underwent radical hysterectomy and pelvic lymph node dissection, without preoperative chemotherapy, between January 2006 and December 2012 were reviewed. Tumor budding was evaluated in routinely-stained sections and defined as detached single cells or clusters of fewer than 5 cells in a tumor invasive front and was stratified based on the number of bud counts in 10-high-power fields as low (follow-up outcomes were assessed. Results: Of 129 patients, a high tumor bud count was observed in 15 (11.6%), positively associated with
This study investigated whether E-Cadherin and vimentin markers had the potential to predict clinical outcomes in lung adenocarcinoma patients treated with
Background: A steep increase in the incidence of esophageal adenocarcinoma has been observed between 1973 and 2001, but recent trends have not been reported. Our aim was to examine recent trends in esophageal adenocarcinoma incidence.. Methods: We used the Surveillance Epidemiology and End Results database of the National Cancer Institute to identify all patients who were diagnosed with esophageal adenocarcinoma between 1973 and 2006. Incidence trends were analyzed for esophageal adenocarcinoma overall and by stage using joinpoint regression.. Results: Overall esophageal adenocarcinoma incidence increased from 3.6 per million in 1973 to 25.6 per million in 2006. Incidence trend analysis, however, suggests that the increase has slowed, from an 8.2% annual increase prior to 1996 to 1.3% increase in subsequent years (P = 0.03). Stage-specific trend analyses suggest that the change in overall esophageal adenocarcinoma incidence largely reflects a plateau in the incidence of early stage disease. Its ...
A macrophage-mediated antibody-dependent cellular cytotoxic reaction has been described in a syngeneic murine mammary adenocarcinoma model. The antibody appears to be present in two forms, one apparently complexed with antigen and the other identified as 7S immunoglobulin on Sephadex G-200 and as the IgG2a subclass by blocking of Fc receptors on the macrophages. This antibody is first detected in mice with regressing tumors. Tumor cells from immune mice appear to be coated with this antibody, as they are sensitive to the effects of normal macrophages in vitro, whereas tumor cells from immunologically compromised mice are not. Thus, a macrophage-dependent reaction probably is relevant in the in situ immune defenses against this tumor.. ...
The p63 gene is a recently discovered member of the p53 family located at chromosome 3q27Many studies have reported that overexpression of p63 can mimic p53 activities by binding DNA, activating transcription, and inducing apoptosis.. Various studies proved p63 as a marker of basal cells in normal salivary glands, breast, prostate, respiratory and squamous epithelia, and of tumor cells from various malignancies. Still, p63 has been the subject of relatively few studies in lung adenocarcinoma, and breast carcinoma, and no study has described the correlation of p63 with pancreatic ductal adenocarcinoma.. In the current study, we aim to evaluate the prognostic value of the expression of p63 in the lung adenocarcinoma, breast adenocarcinoma, and pancreatic ductal adenocarcinoma. We will achieve this aim by collecting clinical data retrospectively from the patients medical records as well as assessing the histological sections and performing immunohistochemical staining for p63. ...
Background Even if detected at an early stage, a substantial number of lung cancers relapse after surgery. Patients with such tumors are likely to benefit from adjuvant therapy, but methods for identifying such patients have yet to be established.. Methods We retrospectively analyzed multiple cohorts totaling 1744 patients who underwent resection of lung adenocarcinoma. Expression of actinin-4 protein in tumors was evaluated immunohistochemically, and copy numbers of the actinin-4 (ACTN4) gene were determined by fluorescence in situ hybridization.. Results Amplification of the ACTN4 gene correlated significantly with smoking history (P = 0.02), pathological stage (P = 0.002), and histological differentiation (P < 0.001, chi-squared test). Overall survival was significantly worse for patients with stage I lung adenocarcinoma harboring ACTN4 gene amplification than for those with tumors showing no such gene amplification (P < 0.001, log-rank test). Multivariate analysis revealed ACTN4 gene ...
The application of immunotherapeutic strategies that target the most potent antigen presenting cell, the dendritic cell (DC), are likely to substantially increase the magnitude of the anti-tumor immune response. Although there are issues of activation state and antigen load, mechanisms to increase the number of DCs available to the immune system are among the first steps in development of affective DC based immunotherapeutic strategies. The Central Hypothesis of our study is: Administration of Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) to patients with pancreatic adenocarcinoma will result in enhance recruitment of DCs to the sentinel lymph node, into the peripheral blood, and/or tumor site. We propose performing a phase I, dose escalation, clinical trial of systemic and intra-tumoral GM-CSF administration for the treatment of pancreatic adenocarcinoma. This trial will be designed to assess toxicity and immunologic effects, principally dendritic cell recruitment. Patients with ...
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Nectin-like molecule-5 (Necl-5) is an immunoglobulin (Ig)-like molecule that is up-regulated in many types of cancer cells. It was shown experimentally that Necl-5 enhances cell migration, proliferation, and metastasis, but its clinical significance has not been documented. The aim of this study was to observe the expression of Necl-5 in surgically resected primary lung adenocarcinomas and to investigate its clinical significance. A total of 63 surgically resected primary pulmonary adenocarcinoma tissues were investigated by immunohistochemistry for the expression of Necl-5. The relationship between expression of Necl-5 and clinicopathological features was analyzed, and the influence of Necl-5 expression on outcomes in these patients was assessed. A strong expression of Necl-5 by cancer cells was observed in 43 of the 63 tumors. The overexpression of Necl-5 by cancer cells was significantly associated with lymph node metastasis (P = 0.0398), TNM staging (P = 0.0367), and the bronchioloalveolar ...
Esophageal adenocarcinoma is a deadly cancer with increasing incidence in the United States, but mechanisms underlying pathogenesis are still mostly elusive. In addressing this question, we assessed gene fusion landscapes by comprehensive RNA sequencing (RNAseq) of 55 pretreatment esophageal adenocarcinoma and 49 nonmalignant biopsy tissues from patients undergoing endoscopy for Barretts esophagus. In this cohort, we identified 21 novel candidate esophageal adenocarcinoma-associated fusions occurring in 3.33% to 11.67% of esophageal adenocarcinomas. Two candidate fusions were selected for validation by PCR and Sanger sequencing in an independent set of pretreatment esophageal adenocarcinoma (N = 115) and nonmalignant (N = 183) biopsy tissues. In particular, we observed RPS6KB1-VMP1 gene fusion as a recurrent event occurring in approximately 10% of esophageal adenocarcinoma cases. Notably, esophageal adenocarcinoma cases harboring RPS6KB1-VMP1 fusions exhibited significantly poorer overall ...
BioAssay record AID 52959 submitted by ChEMBL: Antitumor activity against colon 26 murine adenocarcinoma cells expressed as percent TGI (tumor growth inhibition) at 0.0313 mg/kg i.v. compound dose.
Medical information, Adenocarcinoma of the bronchus. Definition of Adenocarcinoma of the bronchus, symptoms of Adenocarcinoma of the bronchus, treatment of Adenocarcinoma of the bronchus, and prevention of Adenocarcinoma of the bronchus. Exams and Tests Adenocarcinoma of the bronchus.
Identification of the primary sites of metastatic adenocarcinomas is a diagnostic problem, particularly in cases of occult primary neoplasms. We studied the ultrastructural morphology of 16 metastatic adenocarcinomas that presented as effusions to establish organ-specific features that would characterize adenocarcinomas from various sites. The nine cases in which the site of the primary carcinoma was known included seven derived from the breast, one from the ovary and one from the colon. The primary site was unknown in seven cases at the time of presentation. After investigations, the primary site became known in five cases (lung, colon and appendix, one case each, and the ovary in two cases). Ultrastructurally diagnostic features could be detected in gastrointestinal, ovarian, bronchioloalveolar-cell and breast carcinomas. In gastrointestinal carcinomas, the presence of short microvilli with long rootlets was specific for the group. The lamellar inclusions of type II pneumocytes were diagnostic ...
PURPOSE: To better understand the complete genomic architecture of lung adenocarcinoma. EXPERIMENTAL DESIGN: We used array experiments to determine copy number variations and sequenced the complete exomes of the 247 lung adenocarcinoma tumor samples along with matched normal cells obtained from the same patients. Fully annotated clinical data were also available, providing an unprecedented opportunity to assess the impact of genomic alterations on clinical outcomes. RESULTS: We discovered that genomic alternations in the RB pathway are associated with significantly shorter disease-free survival in early-stage lung adenocarcinoma patients. This association was also observed in our independent validation cohort. The current treatment guidelines for early-stage lung adenocarcinoma patients recommend follow-up without adjuvant therapy after complete resection, except for high-risk patients. However, our findings raise the interesting possibility that additional clinical interventions might provide medical
AZD9291 is a novel, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), which is administered orally. It has been proven effective in non-small cell lung cancer (NSCLC) patients, with both EGFR-sensitizing and EGFR T790M mutations in preclinical models. However, the potential therapeutic effects of AZD9291 combined with other modalities, including ionizing radiation, are not well understood. The presence of AZD9291 significantly increases the cell-killing effects of radiation in PC-9-IR cells with a secondary EGFR mutation (T790M), which was developed from NSCLC PC-9 cells (human lung adenocarcinoma cell with EGFR 19 exon 15 bp deletion) after chronic exposure to increasing doses of gefitinib, and in H1975 cells (human lung adenocarcinoma cell with EGFR exon 20 T790M mutation de novo), but not in PC-9 cells or in H460 cells (human lung adenocarcinoma cell with wild-type EGFR ...
Severe and longstanding reflux is a significant risk factor for oesophageal odenocarcinoma (OA). This risk may be independent of the presence of Barretts oesophagus. This article assess the proportion of outpatient referrals for OGD, which are at high risk for OA according to the Lagergren criteria and the implications for screening this group for continued surveillance. Half of those attending for OGD for reflux symptoms have a Lagergren reflux score consistent with an odds ratio 20 times that of a control population for oesophageal adenocarcinoma at 5 years ...
In patients without a known history of malignancy such as ours, diagnosis of an extra-testicular metastasis on the initial ultrasound is difficult. The sonographic differential diagnosis includes other extra-testicular benign and malignant tumours. Clinical correlation is essential to enable better differentiation of malignant from benign lesions. The clinical finding of a hard scrotal mass in our patient raised concerns of malignancy, and hence surgical exploration was undertaken. The final diagnosis still depends on biopsy and pathological study. In our patient, histology and immunological studies of the scrotal wall biopsy hinted at the final diagnosis of occult gastric adenocarcinoma. Although positron emission tomography-CT may be useful for seeking an occult primary malignancy, it is not commonly used as a first-line imaging modality in patients presenting with a scrotal wall lesion. However, it could be offered to search for an underlying primary when histology shows adenocarcinoma but ...
Sialyl Lewis X-i antigen has been used as a tool for the clinical assessment of lung cancers, especially lung adenocarcinoma. However, the carbohydrate antigens including sialyl Lewis X-i antigen are also increased in some patients with non-malignant lung diseases such as IPF without coexistent malignancy.8-12 There is as yet no test to make a specific diagnosis in patients with raised levels of the antigen. When increased serum levels of the antigen are found in patients with IPF without a suspicious mass on the chest CT scan, further invasive and costly tests are often considered to rule out adenocarcinoma originating from other organs. If the core proteins of the antigen in patients with lung adenocarcinoma are not the same as those in patients with IPF, it is expected that the pattern of expression would differ on Western blotting analysis. In order to establish the specific test for a differential diagnosis we evaluated the pattern of expression of the antigen in serum samples of lung ...
Despite all of the advances in unraveling the molecular and biologic initiation and progression of cancer (32, 33), the knowledge of these processes in lung adenocarcinoma is still poor, resulting in little improvement in patient survival (5).. In this article, we revealed the potential of a population of human lung adenocarcinoma cells, characterized for expressing Lgr6, that are selected through the progression of the cancer and that harbor cancer stem cell-like properties. As a consequence of p53-mutating inactivation, there is a dysregulation of the balance between two pathways, the miR-17-92 family of miRNAs and the p38α kinase, that control normal homeostasis in human Lgr6+ lung stem cells. Lack of p53 leads to loss of its repressive effects on miR-17-92 cluster expression. miR-17-92 overexpression is a common feature in lung cancer. We have now shown that a miR-17-92 member, miR-19, downregulates p38α.. We have previously reported a deficiency in p38α protein in human lung cancer (20). ...
Results All normal colonic mucosa showed SIRT1 expression with no exception, and 42 (80.8%) of 52 adenomatous polyps were positive for SIRT1. However, only 208 (41.9%) of 497 colorectal adenocarcinomas were positive. Moreover, 45 (35.7%) of 126 metastatic tissues were positive. Collectively, the SIRT1 expression was gradually decreased during carcinogenesis and tumour progression. The associations between SIRT1 expression and clinicopathological parameters revealed that loss of SIRT1 expression was associated with proximal tumour location, mucinous histology and defective mismatch repair protein expression. This suggests that loss of SIRT1 expression is associated with the microsatellite instability phenotype of colorectal adenocarcinoma. In survival analyses, the loss of SIRT1 expression was significantly associated with overall survival (p=0.027, log-rank test) in univariable analysis, but multivariable analysis failed to achieve significance. ...
The Korean Journal of Pathology 2011; 45: 79-86 DOI: 10.4132/KoreanJPathol.2011.45.1.79 Cytologic Features of Prostatic Adenocarcinoma in Urine: Comparison with Urothelial Carcinoma Lucia Kim ∙ Joo Young Song Suk Jin Choi ∙ In Suh Park Jee Young Han ∙ Joon Mee Kim Young Chae Chu Department of Pathology, Inha University School of Medicine, Incheon, Korea Received: March 9, 2010 Accepted: November 19, 2010 Corresponding Author Young Chae Chu, M.D. Department of Pathology, Inha University Hospital, 7-206 Sinheung-dong 3-ga, Jung-gu, Incheon 400-711, Korea Tel: +82-32-890-3984 Fax: +82-32-890-3464 E-mail: [email protected] *This study was supported by Inha University Research Grants. Background: Prostate adenocarcinoma (PACa) cells are rarely identified in urine cytology specimens and might be easily overlooked or misdiagnosed as urothelial neoplasm when clinically unsuspected. Methods: We reviewed 19 urine cytology specimens obtained from 13 patients with PACa and evaluated the characteristic ...
prostate carcinomas, prostate cancer, prostatic carcinomas, prostatic adenocarcinomas; prostate adenocarcinoma See also: prostate cancer (...)
BETHESDA, Md. -- Strains of Helicobacter pylori associated with an increased risk of gastric cancer may have a protective effect for esophageal adenocarcinoma, a meta-analysis found.
The 22-1-1 MoAb was generated from mice immunized with SiSo cells that had been derived from adenocarcinoma of the uterine cervix (1) . The 22-1-1 MoAb strongly stained adenocarcinomas of the cervix (87.5%), endometrial adenocarcinomas (66.0%), ovarian adenocarcinomas (58.8%), and SCCs of the uterine cervix (87.7%; Ref. 2 ). In nongynecological cancers, 22-1-1 Ag was detected in esophageal SCCs, gastric adenocarcinomas, colon adenocarcinomas, and pancreatic adenocarcinomas, indicating that the 22-1-1 Ag exists widely in various cancer tissues.. As reported previously, 22-1-1 Ag was shown to be distinct from YH206, GA733, CA125, CEA, and sialyl Lewis molecules in flow cytometric analysis data (2) . The tissue distribution of 22-1-1 Ag was also different from those of CA125 and CA19-9 Ags and CEA. There have been no previous reports about a Mr 78,000 tumor-associated Ag secreted in vaginal discharges of uterine cancer patients that has these characteristics. Moreover, there is a possibility that ...
Immunohistochemical studies on human tumours demonstrated pronounced expression of HIF-1α in many common tumours, which probably represents a consequence of both hypoxia within the tumour and various genetic disturbances in neoplastic cells [11]. Moreover, HIF-1α expression was shown to manifest positive correlation with expression of VEGF and with density of microvessels in most of tumours of central nervous system [12], ovarian cancer [13], ductal mammary carcinoma [14], colon adenocarcinoma [15], endometrial adenocarcinoma [16], ductal pancreatic adenocarcinoma [17], small-cell pulmonary carcinoma [18]. The relationship seems to be of significance since not only elevated HIF-1α expression is linked to increased VEGF levels, but absence of HIF-1α expression in several cases results in a decreased VEGF level and, thus, an inhibited process of neoangiogenesis. The latter observation has been corroborated in studies on embryonal stem cells of mice devoid of HIF-1α expression, in which VEGF ...
Sigma-Aldrich offers abstracts and full-text articles by [Sang-Hak Lee, Jae Kook Nam, Jong-Kook Park, Joo-Ho Lee, Do Sik Min, Hyo-Jeong Kuh].
Another name for Adenocarcinoma of the Bronchus is Adenocarcinoma of the Bronchus. What is adenocarcinoma of the bronchus? A person with adenocarcinoma ...
Epithelial tumor cells undergo epithelial-to-mesenchymal transition (EMT) to gain metastatic activity. Competing endogenous RNAs (ceRNAs) have binding sites for a common set of microRNAs (miRs) and regulate each others expression by sponging miRs. Here, we address whether ceRNAs govern EMT-driven metastasis. High miR-181b levels were correlated with an improved prognosis in human lung adenocarcinomas, and metastatic tumor cell lines derived from a murine lung adenocarcinoma model in which metastasis is EMT-driven were enriched in miR-181b targets. The EMT-activating transcription factor ZEB1 relieved a strong basal repression of integrin-α1 (ITGA1), which in turn upregulated adenylyl cyclase 9 (ADCY9) by sponging miR181b. Ectopic expression of the ITGA1 3 untranslated region reversed miR-181b-mediated metastasis suppression and increased the levels of ADCY9, which promoted ZEB1-driven tumor cell migration and metastasis. In human lung adenocarcinomas, ITGA1 and ADCY9 levels were positively ...
Epithelial tumor cells undergo epithelial-to-mesenchymal transition (EMT) to gain metastatic activity. Competing endogenous RNAs (ceRNAs) have binding sites for a common set of microRNAs (miRs) and regulate each others expression by sponging miRs. Here, we address whether ceRNAs govern EMT-driven metastasis. High miR-181b levels were correlated with an improved prognosis in human lung adenocarcinomas, and metastatic tumor cell lines derived from a murine lung adenocarcinoma model in which metastasis is EMT-driven were enriched in miR-181b targets. The EMT-activating transcription factor ZEB1 relieved a strong basal repression of integrin-α1 (ITGA1), which in turn upregulated adenylyl cyclase 9 (ADCY9) by sponging miR181b. Ectopic expression of the ITGA1 3 untranslated region reversed miR-181b-mediated metastasis suppression and increased the levels of ADCY9, which promoted ZEB1-driven tumor cell migration and metastasis. In human lung adenocarcinomas, ITGA1 and ADCY9 levels were positively ...
Epithelial tumor cells undergo epithelial-to-mesenchymal transition (EMT) to gain metastatic activity. Competing endogenous RNAs (ceRNAs) have binding sites for a common set of microRNAs (miRs) and regulate each others expression by sponging miRs. Here, we address whether ceRNAs govern EMT-driven metastasis. High miR-181b levels were correlated with an improved prognosis in human lung adenocarcinomas, and metastatic tumor cell lines derived from a murine lung adenocarcinoma model in which metastasis is EMT-driven were enriched in miR-181b targets. The EMT-activating transcription factor ZEB1 relieved a strong basal repression of integrin-α1 (ITGA1), which in turn upregulated adenylyl cyclase 9 (ADCY9) by sponging miR181b. Ectopic expression of the ITGA1 3 untranslated region reversed miR-181b-mediated metastasis suppression and increased the levels of ADCY9, which promoted ZEB1-driven tumor cell migration and metastasis. In human lung adenocarcinomas, ITGA1 and ADCY9 levels were positively ...
Epithelial tumor cells undergo epithelial-to-mesenchymal transition (EMT) to gain metastatic activity. Competing endogenous RNAs (ceRNAs) have binding sites for a common set of microRNAs (miRs) and regulate each others expression by sponging miRs. Here, we address whether ceRNAs govern EMT-driven metastasis. High miR-181b levels were correlated with an improved prognosis in human lung adenocarcinomas, and metastatic tumor cell lines derived from a murine lung adenocarcinoma model in which metastasis is EMT-driven were enriched in miR-181b targets. The EMT-activating transcription factor ZEB1 relieved a strong basal repression of integrin-α1 (ITGA1), which in turn upregulated adenylyl cyclase 9 (ADCY9) by sponging miR181b. Ectopic expression of the ITGA1 3 untranslated region reversed miR-181b-mediated metastasis suppression and increased the levels of ADCY9, which promoted ZEB1-driven tumor cell migration and metastasis. In human lung adenocarcinomas, ITGA1 and ADCY9 levels were positively ...
CHICAGO, IL--(Marketwired - October 30, 2014) - Lung cancer patients with minimally invasive adenocarcinoma (MIA) have similar, positive five-year disease-free survival (DFS) and overall survival (OS) rates as patients with adenocarcinoma in-situ (AIS), according to research presented today at the 2014 Chicago Multidisciplinary Symposium in Thoracic Oncology. The Symposium is...
Survival analysis showed that patients with stage I adenocarcinoma with TTF1 expression had a longer median overall survival than those without expression (n = 43, 44.3 v 26.2 months, P = .05 for the first cohort; n = 87; 49.7 v 38.5 months, P = .03 for the second cohort) Multivariate analysis revealed an independent lower risk of death for patients with stage I adenocarcinoma with TTF1-expressing tumors (hazard ratio = 0.479, 95% CI, 0.235 to 0.977; P = .043 ...
Barretts esophagus is the precursor of most esophageal adenocarcinomas and a large proportion of esophagogastric junctional adenocarcinomas. These diseases are...
Lineage analysis of early and advanced tubular adenocarcinomas of the stomach: continuous or discontinuous. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
The first generation EGFR TKIs gefitinib and erlotinib provide significant clinical benefit in patients with advanced lung adenocarcinoma harbouring activating EGFR mutants (EGFRm+), but patients will ultimately develop disease progression due to acquired resistance. Acquisition of the EGFR T790M mutation is the most common mechanism of drug resistance, detected in more than 50% of gefitinib/erlotinib resistant patients. Current therapeutic strategies are limited for advanced lung adenocarcinoma patients with EGFR T790M (EGFRm+/T790M), so this remains a key area of unmet need. AZD9291 (structure to be disclosed at meeting) is an oral, irreversible, third generation, selective inhibitor of both EGFR activating (EGFRm+) and resistance (EGFRm+/T790M) mutations. The mechanistic and functional activity of AZD9291 was characterised in vitro and in vivo across a number of cell lines harbouring various EGFR-mutations or wild type EGFR. Presented data shows AZD9291 potently inhibits EGFR phosphorylation ...
N Engl J Med. 2009 Aug 19; Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, Sunpaweravong P, Han B, Margono B, Ichinose Y, Nishiwaki Y, Ohe Y, Yang JJ, Chewaskulyong B, Jiang H, Duffield EL, Watkins CL, Armour AA, Fukuoka MBACKGROUND: Previous, uncontrolled studies have suggested that first-line treatment with gefitinib would be efficacious in selected patients with non-small-cell lung cancer. METHODS: In this phase 3, open-label study, we randomly assigned previously untreated patients in East Asia who had advanced pulmonary adenocarcinoma and who were nonsmokers or former light smokers to receive gefitinib (250 mg per day) (609 patients) or carboplatin (at a dose calculated to produce an area under the curve of 5 or 6 mg per milliliter per minute) plus paclitaxel (200 mg per square meter of body-surface area) (608 patients). The primary end point was progression-free survival. RESULTS: The 12-month rates of progression-free survival were 24.9% with gefitinib and 6.7% with ...
Papillary predominant adenocarcinoma of lung is a subtype of adenocarcinoma of the lung. Epidemiology It may account for 7-12% of all lung adenocarcinomas. There may be predilection in female non smokers 1. Pathology It this form papillary st...
Introdução - O adenocarcinoma de esôfago apresenta aumento de frequência nas últimas décadas, particularmente em países desenvolvidos. O esôfago de Barrett é reconhecido como a principal lesão precursora e o estudo da sequência metaplasia-displasia-adenocarcinoma mostra a ocorrência de alterações genéticas desde suas fases mais incipientes. As alterações no p16INK4a são relatadas como frequentes no esôfago de Barrett e no carcinoma de esôfago. Objetivo - Verificar a prevalência da expressão imunoistoquímica da proteína p16INK4a em exames anatomopatológicos de pacientes com adenocarcinoma de esôfago. Método - A população do estudo foi constituída de 37 pacientes com adenocarcinoma de esôfago. A expressão da proteína p16 foi detectada por meio de análise imunoistoquímica, com anticorpo primário p16INK4aAb-7, clone 16P07, NeoMarkers e avaliada de acordo com o Sistema de Escore de Imunorreatividade (Immunoreactive scoring system - IRS) modificado. Resultados - No ...
Lung adenocarcinoma is a type of non-small cell lung cancer that originates in the pulmonary glandular cells, which secrete mucus-like fluids. Adenocarcinomas accounts for approximately 40 percent of...
Invasive mucinous adenocarcinoma (IMA) is a mucinous variant of lepidic predominant lung adenocarcinoma (LPA) and associated with a worse prognosis. We postulated that cytokine expression would enable us to differentiate IMA from LPA in terms of prognosis and acquisition of pro-tumoural capacities. A 30-cytokine panel was assessed in bronchoalveolar lavage fluids (BALF) from IMA (n=38), LPA (n=25) and control samples (n=7). We investigated the expression of differentially expressed cytokines and splice variants of their receptors in surgical samples. The presence of EGFR and KRAS mutations were determined. We also examined the expression of cytokines and splice variants of their receptors in different cell lines, exploring their functional impact on signalling pathways, proliferation and migration. Only C-X-C motif chemokine 10 (CXCL10) was differentially expressed, namely overexpressed in IMA BALF compared with LPA. CXCL10 overexpression in BALF was linked to a worse prognosis. In surgical samples,
Another name for Adenocarcinoma of the Lung is Adenocarcinoma of the Bronchus. Facts about adenocarcinoma of the bronchus: * Lung cancer is the second ...
Home » Addition compound » Addition polymer » Adductor muscle » Adenitis » Adenocarcinoma. Adenocarcinoma (Science: oncology, tumour) a form of cancer that involves cells from the lining of the walls of many different organs of the body. Breast cancer is a type of adenocarcinoma. ...
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INTRODUCTION Giant prostatic adenocarcinoma represents a rare and challenging treatment dilemma. CASE PRESENTATION We describe a case of an otherwise healthy 71-year-old African male who presented with a PSA of 5800 ng/ml and a prostate volume of over 1000cc. Unique aspects of this case include the size of the prostate, the apparent absence of distant metastases, and the safe usage of transabdominal biopsy of this mass. CONCLUSION We present this case report and review of literature to generate further discussion amongst readers as to management options for this difficult case ...
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The prostanoid thromboxane (TX)A2 signals through the TPα and TPβ isoforms of T Prostanoid receptor (TP) that are transcriptionally regulated by distinct promoters termed Prm1 and Prm3, respectively, within the TBXA2R gene. We recently demonstrated that expression of TPα and TPβ is increased in PCa, differentially correlating with Gleason grade and with altered CpG methylation of the individual Prm1/Prm3 regions within the TBXA2R. The current study sought to localise the sites of CpG methylation within Prm1 and Prm3, and to identify the main transcription factors regulating TPβ expression through Prm3 in the prostate adenocarcinoma PC-3 and LNCaP cell lines ...
Adenocarcinomas are diagnosed like other cancers. They are usually detected by taking a biopsy of the tumor and examining it under the microscope. If such a tumor is discovered, it requires prompt treatment. This is essential because the cancer may spread to other organs as well. Treatment includes surgical removal of the tumor to prevent its growth. After surgery, the patient may undergo chemotherapy and radiation to prevent the adenocarcinoma coming back.. ...
HealthTap: Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Wu on causes of metastatic adenocarcinoma: There are many things that are associated with the decelopment of prostate cancer but no definite causes. There is such a thing as inheritable prostate cancer but it is a far less common variant.
Lung cancer is the leading cause of cancer-related mortality worldwide. Radiotherapy is often applied for treating lung cancer, but it often fails because of the relative non-susceptibility of lung cancer cells to radiation. MicroRNAs (miRNAs) have been reported to modulate the radiosensitivity of lung cancer cells and have the potential to improve the efficacy of radiotherapy. The purpose of this study was to identify a miRNA that can adjust radiosensitivity in lung adenocarcinoma cells. Two lung adenocarcinoma cell lines (CL1-0 and CL1-5) with different metastatic ability and radiosensitivity were used. In order to understand the regulatory mechanisms of differential radiosensitivity in these isogenic tumor cells, both CL1-0 and CL1-5 were treated with 10 Gy radiation, and were harvested respectively at 0, 1, 4, and 24 h after radiation exposure. The changes in expression of miRNA upon irradiation were examined using Illumina Human microRNA BeadChips. Twenty-five miRNAs were identified as ...
Lung tumor is the leading cause of cancer death worldwide, and brain metastasis is usually a major cause of morbidity and mortality in lung cancer. This study revealed that activates through the release of miR-218 inhibition on in lung adenocarcinoma. Introduction Lung cancer represents the leading cause of cancer-related death in the Western world. This disease has a 5-12 months overall survival rate of only 15%, and this has not improved during recent decades [1]. In Taiwan, lung cancer may be the leading reason behind cancers loss of life [2] also, and adenocarcinoma may be the main histological type (52.5%). Metastasis is a significant reason behind mortality and morbidity in 82034-46-6 IC50 lung cancers. Operative resection of principal lung cancers is certainly accompanied by tumor recurrence at faraway sites often, like the lymph nodes [3], bone tissue [4], and human brain [5]. Around 30% of sufferers with lung cancers develop human brain metastasis [5]. Nevertheless, the systems ...
In addition to its ability to act as a promising inducer of tumor-specific cell death, TRAIL has also been shown to stimulate signaling pathways leading to cancer cell survival. We examined the changes of anti-apoptotic Mcl-1 protein level following TRAIL treatment of human cell lines representing different stages of colon carcinogenesis-adenocarcinoma (HT-29, HCT116) or secondary metastasis (SW620), together with cell line derived from human fetal colon (FHC). While TRAIL was capable of triggering an anti-apoptotic signaling leading to significant early ERK-mediated transcriptional up-regulation of Mcl-1 in selected colon adenocarcinoma cell lines, none or very limited effects were demonstrated in cell lines derived from colon lymph node metastasis or fetal colon, respectively. We demonstrated an immediate impact of Mcl-1 protein level manipulations on the Course of early acute apoptotic response of colon adenocarcinoma cells to TRAIL. It is therefore essential to consider the dynamics of ...
Loss of epithelial differentiation and extracellular matrix (ECM) remodeling are known to facilitate cancer progression and are associated with poor prognosis in patients with lung cancer. We have identified Receptor-interacting serine/threonine protein kinase 4 (RIP4) as a regulator of tumor differentiation in lung adenocarcinoma (AC). Bioinformatics analyses of human lung AC samples showed that poorly differentiated tumors express low levels of RIP4, whereas high levels are associated with better overall survival. In vitro, lung tumor cells expressing reduced RIP4 levels showed enhanced activation of STAT3 signaling and had a greater ability to invade through collagen. In contrast, overexpression of RIP4 inhibited STAT3 activation, which abrogated interleukin-6-dependent induction of lysyl oxidase, a collagen cross-linking enzyme. In an autochthonous mouse model of lung AC initiated by Kras(G12D) expression with loss of p53, Rip4 knockdown tumors progressed to a poorly differentiated state ...
Cancer Epidemiol Biomarkers Prev. 2011 Nov;20(11):2450-6. doi: 10.1158/1055-9965.EPI-11-0547. Epub 2011 Sep 19. Research Support, N.I.H., Extramural
Discussion:. The overall morphology of this case is typical of a small cell carcinoma, and the immunoprofile supports the diagnosis. The differential diagnosis is listed in question 1. The history of prostatic adenocarcinoma, brain metastases and diffuse lymphadenopathy raise the possibility of metastatic prostatic adenocarcinoma. However the prostate adenocarcinoma typically has prominent nucleoli and acinar-like cell arrangement, which clearly were not seen in this case. The oval shaped nuclei, fine chromatin and nuclear molding are against lymphoma. The small size of tumor cells, lack of prominent nucleoli and lack of abundant cytoplasm are against LCNEC. Distinction from SCC, basaloid type can be difficult based on Diff-Quick and H/E stains only. Positive staining for neuroendocrine markers and lack of history SCC are against poorly differentiated basaloid SCC. The site of origin of metastatic SmCC cannot be determined based on histopathologic or immunophenotypic findings, and requires ...
High-risk patients like current and former heavy smokers are recommended to undergo screening with low-dose CT scan by the US Preventative Services Task Force.[6][7]. If a lung nodule is found, the next step depends on the and imaging characteristics of the lung nodule. If a nodule is suspicious for lung cancer, PET/CT may be performed followed by biopsy or surgical excision. Based upon National Comprehensive Cancer Network Guidelines the next step is a full CT of the thorax and abdomen with contrast (including adrenals), bronchoscopy, mediastinal lymph node evaluation, complete blood count and blood chemistry profile.. Brain MRI is recommended for those with Stage II, III, or IV disease to rule out metastasis. These results are then synthesized to generate a clinical stage to guide treatment.. If bone metastases are suspected, then a bone scan should be obtained.. PET scan is usually used to assess for recurrence of the disease.. Sputum cytology is rarely helpful as most adenocarcinomas are ...
A neoplasm, or tumor, can be either benign or malignant in nature. A carcinoma is a type of malignant tumor found in both humans and animals, and tends to be particularly malignant, with recurring growth after surgical excision. Adenocarcinomas are characterized as glandular in structure, and/or originating in the glandular tissue. This type of tumor is rare in dogs, but like other carcinomas it grows rapidly and metastasizes to distant parts and organs of the body.
The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: An evidence based appraisal
A total of 218 patients with lung adenocarcinoma (EGFR analyzed) who were seen at our clinic between 2012 and 2014 were included in the study. The results of the 18 F-FDG-PET scans for each patient were retrospectively recorded with the associated medical documents. ALK rearrangements were analyzed in 166 of the 218 patients, while 50 of the 218 patients were analyzed for KRAS mutational status. SPSS 15.0 for Windows was used for statistical analysis.. ...
Colorectal adenocarcinoma antibody [C241:5:1:4] for IHC-P. Anti-Colorectal adenocarcinoma mAb (GTX17252) is tested in Human samples. 100% Ab-Assurance.
Andrew Ko, MD, provides his perspective on PEGPH20 given the phase III HALO-301 trial and potential drug combinations in the setting of pancreatic adenocarcinoma.
Selected images of colorectal adenocarcinoma analyzed by the disorderliness score formula. The scores are presented in the lower right corners of each image. No
Background Lung adenocarcinoma (LAD) has extreme genetic variation among patients, which is currently not well understood, limiting progress in therapy development and research. LAD intrinsic molecular subtypes are a validated stratification of naturally-occurring gene expression patterns and encompass different functional pathways and patient outcomes. Patients may have incurred different mutations and alterations that led to the different subtypes. We hypothesized that the LAD molecular subtypes co-occur with distinct mutations and alterations in patient tumors. Methodology/Principal Findings The LAD molecular subtypes (Bronchioid, Magnoid, and Squamoid) were tested for association with gene mutations and DNA copy number alterations using statistical methods and published cohorts (n = 504). A novel validation (n = 116) cohort was assayed and interrogated to confirm subtype-alteration associations. Gene mutation rates (EGFR, KRAS, STK11, TP53), chromosomal instability, regional copy number, and
To research the relationships between your appearance of MUC5B and clinicopathological variables, the expression of MUC5B was studied. the mix of MUC5B with TTF-1 can be a good marker for adenocarcinomas. The diagnostic accuracies of TTF-1 and MUC5B for adenocarcinoma had been 83.8% and 70.4%, respectively. The precision risen to 94.3% when both factors were combined. In success evaluation, the MUC5B(Large)/TTF-1(?) group was considerably connected with a poorer result weighed against the MUC5B(Low)/TTF-1(+) group (p < 0.0001). Todays study suggested how the mix of MUC5B and TTF-1 manifestation pays to for discriminating adenocarcinomas from squamous cell carcinomas, yielding prognostic significance in individuals with lung adenocarcinoma. Major lung cancer may be the leading reason behind cancer death, as well as the percentage of adenocarcinoma (AC) among lung malignancies continues to be increasing steadily in recent years1,2. While medical resection may be the ideal treatment for ...
To research the relationships between your appearance of MUC5B and clinicopathological variables, the expression of MUC5B was studied. the mix of MUC5B with TTF-1 can be a good marker for adenocarcinomas. The diagnostic accuracies of TTF-1 and MUC5B for adenocarcinoma had been 83.8% and 70.4%, respectively. The precision risen to 94.3% when both factors were combined. In success evaluation, the MUC5B(Large)/TTF-1(?) group was considerably connected with a poorer result weighed against the MUC5B(Low)/TTF-1(+) group (p < 0.0001). Todays study suggested how the mix of MUC5B and TTF-1 manifestation pays to for discriminating adenocarcinomas from squamous cell carcinomas, yielding prognostic significance in individuals with lung adenocarcinoma. Major lung cancer may be the leading reason behind cancer death, as well as the percentage of adenocarcinoma (AC) among lung malignancies continues to be increasing steadily in recent years1,2. While medical resection may be the ideal treatment for ...
Human Lung Slide (Adenocarcinoma) (5 slides/pk) Slide for IHC HTS-10106 Human Lung Slide (Adenocarcinoma) (5 slides/pk) Slide for IHC HTS-10106
The 5-year overall survival and recurrence-free rates were 86.8% and 84.8%, respectively. During follow-up, 59 (7.9%) patients developed recurrence. Univariate analysis showed that micropapillary/solid predominant group had significantly lower probability of FFR (P = 0.001) in node-negative lung adenocarcinoma of 3cm or smaller. Older age (P = 0.007), greater tumor size (P = 0.006), and micropapillary/solid predominant group (P = 0.031) had significantly lower probability of FFR in multivariate analysis. ...
The homeodomain transcription factor, PITX2 is associated with tumorigenesis of multiple cancers. In this research, we aimed to study the expression, function and mechanism of PITX2 in lung adenocarcinoma (LUAD). The TCGA dataset was used to analyze the expression and clinical significance of PITX2 in LUAD. The expression of PITX2 in tumor samples and LUAD cell lines was examined by quantitative real-time PCR (qRT-PCR) and western blotting. Small interfering RNAs (siRNAs) were constructed to knockdown PITX2 and to determine the physiological function of PITX2 in vitro. Xenograft model was used to confirm the role of PITX2 in vivo. PITX2 was overexpressed in LUAD and patients with high level of PITX2 had a worse overall survival and an advanced clinical stage. Knockdown of PITX2 inhibited cell proliferation, migration and invasion of LUAD cells. Further study revealed that the oncogenic role of PITX2 was dependent on activating Wnt/β-catenin signaling pathway, especially by transcriptionally regulating
Since adenocarcinomas begin in the glandular cells of several internal organs, according to the National Institutes of Health, their causes are varied. An adenocarcinoma of the lung, for example, can...
We plan to conduct a phase I/II clinical trial using biweekly gemcitabine, oxaliplatin, and 48-hour infusion of high dose 5-FU/leucovorin to treat patie
We next compared the mutational spectrum of trunk versus nontrunk mutations to explore the relative contribution of mutational processes over time. Significant differences in mutational spectrum were observed in six tumors, which indicated that specific mutational processes were likely operative at different times during development of these tumors (Fig. 3, B and C). Of interest, two former smokers (cases 317 and 330) and the current smoker (case 324) showed significant differences between trunk and nontrunk mutation spectrum with a shift from smoking-associated C,A transversions in trunk mutations to nonsmoker-associated C,T transitions in nontrunk mutations.. Recent evidence has suggested that APOBEC activity is a major source for C,T and C,G mutations (12, 26). We therefore investigated whether there is evidence of an APOBEC mutational process in this subset of lung adenocarcinomas. On average, 28% of all mutations had a specific substitution pattern (C,T/G at TpCpW sites, where W is A or T), ...
Adenocarcinoma adjectives are listed in this post. Each word below can often be found in front of the noun adenocarcinoma in the same sentence. This reference
MedWorm- Adenocarcinoma comments, Description: MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Adenocarcinoma, ID: 284227, By: Feedage Forager
This proposal aims to understand the role of NKX2-1 amplification, the most common focal copy number alteration of lung adenocarcinoma, in the pathogenesis of t...
In this case-based interview, Mark Socinski, MD, describes the case of a patient with metastatic non-driver lung adenocarcinoma with brain and bone metastases.
Using an ELISA method, the sera of 43 patients with colon adenocarcinoma (CA) and of 26 surgical patients with nonmalignant disease of the gastrointestinal tract were studied for the presence of autoantibodies against cardiolipin (CLP) before and 1 m
The PPC-1 cell line (originally known as Specimen P-3) was established by Brothman and associates in 1987 from a poorly differentiated adenocarcinoma of the prostate.
Non-small cell lung carcinoma harbouring epidermal growth factor receptor (EGFR) mutation, usually progress after an initial response to tyrosine-kinase inhibitors (TKI). Liquid biopsy enables with a simple blood draw the accurate detection of EGFR p.T790M mutation, the most common resistance mechanism, avoiding the more invasive tissue re-biopsy. However, in a subset of cases, resistance mechanisms are more complex featuring both genetic and morphological changes. Here we report the case of a 67 years-old woman, affected by an EGFR mutated lung adenocarcinoma and treated by TKI. At disease progression, the patient developed a morphological transition to squamous cell carcinoma in association to the arising of a PIK3CA p.E542K mutant subclone. This case illustrates that, even in the "liquid biopsy" era, cytology can have still a role by providing an overall assessment of both morphology and genetic TKI resistance mechanisms. ...
If you have ever seen how hotdogs and most sausages are made youd think twice about consuming them. But is it the hotdogs, sausages, and luncheon meats that are causing an increased risk of developing stomach/intestinal/colon cancers or is it the hotdog rolls and sandwich bread?. Did the World Health Organization experts take into account that gluten can be at the root of stomach, intestinal, colon, esophageal, and many other cancers?. Compared to the general population, celiac patients have a much greater risk of developing gastrointestinal lymphoma (24-34x), and the risk is elevated substantially for esophageal and other cancers.*. Other research reports that CD "significantly increases [the] risk of developing small bowel lymphomas by 30 to 40 percent and other gut malignancies by 83-fold."**. "A 10 - 280 fold increased risk of small bowel adenocarcinoma" was found in celiac patients compared to the general population.***. Patients suffering a return of symptoms after reacting positively to ...
The KU-Lu-MPPt3 cells featured adherent monolayers, adherent tufts, and suspended tufts without adhesion under the same culture conditions. The cells were positive for cytokeratin, epithelial cell-adhesion molecules, E-cadherin, mucin-1, thyroid transcription factor-1, vimentin, and anti-programmed death ligand 1. Xenograft tumors clearly demonstrated micropapillary structures. Sequencing and fragment analysis of the epidermal growth factor receptor in the primary tumor tissue and KU-Lu-MPPt3 cells revealed an in-frame deletion E746-A750 in exon 19.. CONCLUSIONS ...
Adenocarcinomas are cancers that, while originating from Glandular Tissue, have the potential to affect different surrounding organs
Treatment for uterine adenocarcinoma may involve a complete hysterectomy to remove the diseased parts of your rabbits organs. This is usually the primary treatment, especially if the cancer has not spread beyond the reproductive organs. A biopsy can be performed to confirm whether the cancer remains in the reproductive organs, or has spread outward to the surrounding organs. Sometimes there is no evidence of the spread of cancer during the time of surgery.. Follow-up care may include chemotherapy and medications for pain management.. ...
Mechanisms behind the strong associations of esophageal adenocarcinoma risk with gastroesophageal reflux (GOR) and body mass remain to be defined. In a nationwide population-based case-control study, we examined associations of polymorphisms in the DNA repair genes XPD, XPC, XRCC1 and XRCC3 with risk of esophageal adenocarcinoma, squamous-cell carcinoma (SCC) and gastric cardia adenocarcinoma, and paid special attention to possible interactions with symptomatic reflux or body mass. We collected blood samples from 96, 81 and 126 interviewed incident cases of esophageal adenocarcinoma, esophageal SCC and gastric cardia adenocarcinoma, respectively, and 472 randomly selected controls, frequency-matched with regard to age and sex. DNA was extracted and polymorphisms in XPD codon 751 (Lys→Gln), codon 312 (Asp→Asn), C insertion in intron 10 of XPD, XPC codon 939 (Lys→Gln), XRCC1 codon 399 (Arg→Gln) and XRCC3 codon 241 (Thr→Met) were examined using PCR-RFLP. Odds ratios (ORs) derived from ...
BACKGROUND: Conflicting roles for Slit2, a protein involved in mediating the processes of cell migration and chemotactic response, have been previously described in prostate cancer. Here we use immunohistochemistry to evaluate the expression of Slit2 in normal donor prostate (NDP), benign prostatic hyperplasia (BPH), high-grade prostatic intraepithelial neoplasia (HGPIN), normal tissue adjacent to prostatic adenocarcinoma (NAC), primary prostatic adenocarcinoma (PCa), and metastatic prostatic adenocarcinoma (Mets). METHODS: Tissue microarrays were immunostained for Slit2. The staining intensities were quantified using automated image analysis software. The data was statistically analyzed using one-way analysis of variance with subsequent Tukey tests for multiple comparisons or a nonparametric equivalent. Eleven cases of NDP, 35 cases of NAC, 15 cases of BPH, 35 cases of HGPIN, 106 cases of PCa, and 37 cases of Mets were analyzed. RESULTS: Specimens of PCa and HGPIN had the highest absolute ...
BackgroundHeparan sulfate proteoglycans (HSPGs) are control elements in Wnt signaling, which bind extracellularly to Wnt ligands and regulate their ability to interact with signal transduction receptors on the cell surface. Sulf-1 and Sulf-2 are novel extracellular sulfatases that act on internal glucosamine-6-sulfate (6S) modifications within HSPGs and thereby modulate HSPG interactions with various signaling molecules, including Wnt ligands. Emerging evidence indicates the importance of reactivated Wnt signaling in a number of cancers, including pancreatic adenocarcinoma.Principle FindingsBoth Sulf proteins were upregulated in human pancreatic adenocarcinoma tumors and were broadly expressed in human pancreatic adenocarcinoma cell lines. Expression of human extracellular sulfatases Sulf-1 and Sulf-2 enhanced Wnt signaling in a reconstituted system. Three of four pancreatic adenocarcinoma cell lines tested exhibited autocrine Wnt signaling, in that extracellular Wnt ligands were required to initiate
Mutations in the tumor suppressor gene TP53 and proto-oncogene PIK3CA and alterations of p53 and PIK3CA AKT mTOR pathways are common events in several human cancers. We focused on the analysis of TP53 and PIK3CA gene variations in adenocarcinoma, squamous cell carcinoma as well as in intraepithelial neoplasia grade 3 of the cervix. DNA samples from 28 cervical adenocarcinoma, 55 squamous cell carcinoma and 31 intraepithelial neoplasia grade 3 (CIN3), previously characterized in terms of human papillomavirus (HPV) prevalence and genotype distribution, were analyzed for TP53 and PIK3CA mutations in the exons 4-9 and exon 9, respectively. Single nucleotide substitutions in TP53 and PIK3CA genes were detected in 36% and 11% of adenocarcinoma, in 16% and in 5% of squamous cell carcinoma, and in 13% and none of CIN 3, respectively. Nucleotide changes in TP53 were significantly more frequent in adenocarcinoma cases than in squamous cell carcinoma and CIN3 (P = 0.035) and were independent from HPV infection
Polymorphous low-grade adenocarcinoma (PLGA) is a rare tumor of the salivary glands that is limited, to a great extent, to the minor salivary glands and commonly, but not exclusively, localized in the palate of the mouth. The major salivary glands are the parotid glands (at the side of the face, below the ears), the...
BARRETTS ESOPHAGUS, GASTROESOPHAGEAL REFLUX DISEASE AND ADENOCARCINOMA OF THE ESOPHAGUS Release Date: September 17, 2001 RFA: RFA-DK-02-015 National Institute of Diabetes and Digestive and Kidney Diseases (http://www.niddk.nih.gov) National Cancer Institute (http://www.nci.nih.gov/) Letter of Intent Receipt Date: February 20, 2002 Application Receipt Date: March 20, 2002 THIS RFA USES "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. MODULAR INSTRUCTIONS MUST BE USED FOR RESEARCH GRANT APPLICATIONS REQUESTING LESS THAN $250,000 PER YEAR IN ALL YEARS. MODULAR BUDGET INSTRUCTIONS ARE PROVIDED IN SECTION C OF THE PHS 398 (REVISION 5/2001) AVAILABLE AT https://grants.nih.gov/grants/funding/phs398/phs398.html. PURPOSE This initiative is designed to stimulate and solicit studies to broadly address the problem of Barretts esophagus and its etiology and relationship to gastroesophageal reflux disease (GERD) and its link to the rising incidence of adenocarcinoma of the esophagus. The specific areas of ...
article{9aa15798-23e3-4cc4-98f1-abf7414b28f7, abstract = {,p,The polymeric immunoglobulin receptor (pIgR) is a key component of the mucosal immune system that mediates epithelial transcytosis of immunoglobulins. High pIgR expression has been reported to correlate with a less aggressive tumour phenotype and an improved prognosis in several human cancer types. Here, we examined the expression and prognostic significance of pIgR in pancreatic and periampullary adenocarcinoma. The study cohort encompasses a consecutive series of 175 patients surgically treated with pancreaticoduodenectomy for pancreatic and periampullary adenocarcinoma in Malmö and Lund University Hospitals, Sweden, between 2001-2011. Tissue microarrays were constructed from primary tumours (n = 175) and paired lymph node metastases (n = 105). A multiplied score was calculated from the fraction and intensity of pIgR staining. Classification and regression tree analysis was used to select the prognostic cut-off. Unadjusted and ...
The aim of the present study was to investigate the mutation rate of the epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) patients and to apply logistic regression analysis to investigate the factors associated with EGFR gene mutation to provide data for the treatment of NSCLC. Paraffin tissue, bronchoscopy or pleural effusion specimens were collected from 176 NSCLC patients following pathological diagnosis. The EGFR gene exon 19 delL747-S75linss and delL747-S752ins deletion mutations, and the exon 20 T790M and exon 21 L858R mutations were identified using amplification refractory mutation system analysis. The clinical data and laboratory results of the patients were collected, and the total mutation rate of the EGFR gene in exons 19, 20 and 21 in the 176 NSCLC patients was found to be 48.3% (85/176). In addition, the EGFR gene mutation rate in adenocarcinoma was found to be significantly higher than that in squamous cell and large cell carcinoma (χ²=12.454; ...
Objective: Gastric colonization with the Helicobacter pylori bacterium is a proposed protective factor against oesophageal adenocarcinoma, but its point of action is unknown. We evaluated its associations with Barretts oesophagus, a metaplastic change that is a probable early event in the carcinogenesis of oesophageal adenocarcinoma.. Design: A case-control study. Setting: The Kaiser Permanente Northern California population, a large health services delivery organization Patients: Persons with a new Barretts oesophagus diagnosis (cases) were matched to subjects with gastrooesophageal reflux disease (GORD) without Barretts oesophagus and to population controls. Main Measures: Subjects completed direct in-person interviews and antibody testing for Helicobacter pylori and its cagA protein.. Results: Serologic data were available on 318 Barretts oesophagus cases, 312 GORD patients, and 299 population controls. Patients with Barretts oesophagus were substantially less likely to have antibodies ...
Diagnosis, clinicopathological characteristics and prognosis of pulmonary mucinous adenocarcinoma  Diagnosis, clinicopathological characteristics and prognosis of pulmonary mucinous adenocarcinoma
Primary pulmonary mucinous adenocarcinoma (PPMA) is an uncommon subtype of lung adenocarcinoma. The present study attempted to ... Gaikwad A, Gupta A, Hare S, Gomes M, Sekhon H, Souza C, Inacio J, Lad S and Seely J: Primary adenocarcinoma of lung: A ... A total of 29 patients with PPMA from among 1,469 surgically resected patients with lung adenocarcinoma were enrolled. All of ... Diagnosis, clinicopathological characteristics and prognosis of pulmonary mucinous adenocarcinoma. *Authors: *Fei Sun ...
more infohttps://www.spandidos-publications.com/ol/15/1/489/abstract
Herceptin® (trastuzumab) Breast Cancer, Metastatic Gastric Cancer, Gastroesophageal Junction (GEJ) Adenocarcinoma Anti-HER2...  Herceptin® (trastuzumab) Breast Cancer, Metastatic Gastric Cancer, Gastroesophageal Junction (GEJ) Adenocarcinoma Anti-HER2...
... adenocarcinoma. INDICATIONS: Adjuvant Breast Cancer Herceptin is indicated for adjuvant treatment of HER2-overexpressing node- ... for the treatment of patients with HER2 overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma, who have ... for the treatment of patients with HER2 overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma, who have ... for the treatment of patients with HER2 overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma, who have ...
more infohttps://www.herceptin.com/hcp/
JAIRO | Complete Response of Advanced Invasive Mucinous Adenocarcinoma of the Lung with Gemcitabine and Pemetrexed  JAIRO | Complete Response of Advanced Invasive Mucinous Adenocarcinoma of the Lung with Gemcitabine and Pemetrexed
Complete Response of Advanced Invasive Mucinous Adenocarcinoma of the Lung with Gemcitabine and PemetrexedComplete Response of ... Advanced Invasive Mucinous Adenocarcinoma of the Lung with Gemcitabine and PemetrexedAN00120815. ...
more infohttp://jairo.nii.ac.jp/0028/00018763/en
Papillary Adenocarcinoma<...  Papillary Adenocarcinoma<...
Papillary Adenocarcinoma is a type of sinonasal cancer that is found in the wood working industry due to the exposure to of ... Papillary Adenocarcinoma is characterized by tumor(s) that protrude from the lining of the nasal cavity.. This type of nasal ... Due to the slow growth rate, there is a more positive prognosis than other types of Adenocarcinoma. However, early detection ... industry and experienced prolonged exposure to wood dust are at a much higher risk of developing intestinal type Adenocarcinoma ...
more infohttp://www.allenstewart.com/practice-areas/sinonasal-cancer/types-of-nasal-cancer/papillary-adenocarcinoma/
Association of visceral adiposity with oesophageal and junctional adenocarcinomas.  Association of visceral adiposity with oesophageal and junctional adenocarcinomas.
METHOD: In total, 194 patients (110 with oesophageal/junctional adenocarcinoma, 38 with gastric adenocarcinoma and 46 with ... Adenocarcinoma/classification/*radiography. Aged. Carcinoma, Squamous Cell/classification/*radiography. Case-Control Studies. ... This study compared abdominal fat composition in patients with oesophageal/junctional adenocarcinoma with that in patients with ... RESULTS: Patients with oesophageal/junctional adenocarcinoma had significantly higher TFA and VFA values compared with controls ...
more infohttps://www.lenus.ie/handle/10147/207799
The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma: a population-based case-control study...  The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma: a population-based case-control study...
XRCC1 and XRCC3 with risk of esophageal adenocarcinoma, squamous-cell carcinoma (SCC) and gastric cardia adenocarcinoma, and ... XRCC1 and XRCC3 with risk of esophageal adenocarcinoma, squamous-cell carcinoma (SCC) and gastric cardia adenocarcinoma, and ... Our study suggests that XPD 751Gln allele is a potential genetic marker for susceptibility to esophageal adenocarcinoma. ... We collected blood samples from 96, 81 and 126 interviewed incident cases of esophageal adenocarcinoma, esophageal SCC and ...
more infohttp://oxfordindex.oup.com/view/10.1093/carcin/bgl017
Villoglandular papillary adenocarcinoma of cervix associated with cervical intraepithelial neoplasia : a case report and review...  Villoglandular papillary adenocarcinoma of cervix associated with cervical intraepithelial neoplasia : a case report and review...
villoglandular adenocarcinoma of cervix.pdf - Published Version Restricted to Registered users only Download (1MB) , Request a ... Well differentiated villoglandular adenocarcinoma of uterine cervix is a rare tumour which usually occurs in young women. It is ... Villoglandular papillary adenocarcinoma of cervix associated with cervical intraepithelial neoplasia : a case report and review ... Srilatha, PS and Roy, Alfred (2007) Villoglandular papillary adenocarcinoma of cervix associated with cervical intraepithelial ...
more infohttp://eprints.manipal.edu/136372/
The Hippo signaling effector WWTR1 is a metastatic biomarker of gastric cardia adenocarcinoma | Cancer Cell International |...  The Hippo signaling effector WWTR1 is a metastatic biomarker of gastric cardia adenocarcinoma | Cancer Cell International |...
Gastric cardia adenocarcinoma (GCA) is an aggressive subtype of gastric cancer with a high metastatic rate. However, the ... Gastric cardia adenocarcinoma (GCA) belongs to the type II gastroesophageal junction adenocarcinoma (GEJAC), the most ... Lou L, Wang Y, Cui J, Yan X, Xue L, Li Y. Differential expression of Pim-3, c-Myc, and p-p27 proteins in adenocarcinomas of the ... The Hippo signaling effector WWTR1 is a metastatic biomarker of gastric cardia adenocarcinoma. *Jing Wei1. na1, ...
more infohttps://cancerci.biomedcentral.com/articles/10.1186/s12935-019-0796-z
Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells. - Physiology...  Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells. - Physiology...
... connexin-assembled gap junctions as an alternative route for discharging lactate from pancreatic ductal adenocarcinoma (PDAC) ... Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells. ... Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells. ... connexin-assembled gap junctions as an alternative route for discharging lactate from pancreatic ductal adenocarcinoma (PDAC) ...
more infohttps://www.dpag.ox.ac.uk/publications/680208
v.10, n.3, 6 - Intestinal mucinous adenocarcinoma with metastases to epididymis, testis and tunica albuginea in a dog - BJVP -...  v.10, n.3, 6 - Intestinal mucinous adenocarcinoma with metastases to epididymis, testis and tunica albuginea in a dog - BJVP -...
Guerra Abstract A case of intestinal mucinous adenocarcinoma with metastasis to gonadal tissue is reported. A 13-year-old, male ... 6 Case Report Intestinal mucinous adenocarcinoma with metastases to epididymis, testis and tunica albuginea in a dog Danilo G. ... You Are Here: Home » Banner » v.10, n.3, 6 - Intestinal mucinous adenocarcinoma with metastases to epididymis, testis and ... Intestinal mucinous adenocarcinoma with metastases to epididymis, testis and tunica albuginea in a dog. Danilo G. Wasques, ...
more infohttp://bjvp.org.br/banner/2017/11/v-10-n-3-6-intestinal-mucinous-adenocarcinoma-metastases-epididymis-testis-tunica-albuginea-dog/
Serous papillary adenocarcinoma possibly related to the presence of primitive oocyte-like cells in the adult ovarian surface...  Serous papillary adenocarcinoma possibly related to the presence of primitive oocyte-like cells in the adult ovarian surface...
Serous adenocarcinoma is a type of epithelial ovarian cancer, which is the most common among ovarian cancers. Ovarian cancers ... Serous papillary adenocarcinoma possibly related to the presence of primitive oocyte-like cells in the adult ovarian surface ... humanoocytesovarian surface epitheliumserous adenocarcinoma. Introduction. In fetal ovaries, the number of germ cells reaches a ... They might present a pathological state leading to the manifestation of ovarian serous papillary adenocarcinoma. It has been ...
more infohttps://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-4-13
A rare case of invasive mucinous adenocarcinoma of fallopian tube fimb by S. X. Liang, T. C. Brandler et al.  "A rare case of invasive mucinous adenocarcinoma of fallopian tube fimb" by S. X. Liang, T. C. Brandler et al.
Here we report a moderately differentiated mucinous adenocarcinoma arising in the tubal fimbria in a 70-year-old woman. Patient ... Frozen section and final pathology diagnosis revealed moderately differentiated adenocarcinoma arising in the left fimbria. ... we concluded that this tumor most likely represented a mucinous adenocarcinoma of tubal origin. ... Mucinous adenocarcinoma of the fallopian tube is exceptionally rare and the detailed clinicopathologic features of these tumors ...
more infohttps://academicworks.medicine.hofstra.edu/articles/706/
What is an Adenocarcinoma?  What is an Adenocarcinoma?
Malignant adenocarcinomas invade other tissues and often metastasize.. Diagnosing and treating adenocarcinomas Adenocarcinomas ... What is adenocarcinoma?. Adenocarcinoma is a cancer originating in glandular tissue. The tissues affected are part of a larger ... The leading cancer of the colon is adenocarcinoma, and adenocarcinomas are extremely common in the lungs. Other organs that may ... Which organs are affected with adenocarcinomas?. Adenocarcinoma can occur in some higher mammals, including humans. These ...
more infohttps://www.news-medical.net/health/What-is-an-Adenocarcinoma.aspx
Radiotherapy for Esophageal Adenocarcinoma | SpringerLink  Radiotherapy for Esophageal Adenocarcinoma | SpringerLink
Adenocarcinomas occur in distal esophagus and often involve esophagogastric junction. Radiotherapy plays a key role in ... Kwong D.L.W., Lam K.O. (2018) Radiotherapy for Esophageal Adenocarcinoma. In: Lam A. (eds) Esophageal Adenocarcinoma. Methods ... Radiotherapy Esophageal adenocarcinoma Neoadjuvant Palliative Chemoradiotherapy This is a preview of subscription content, log ... Adenocarcinomas occur in distal esophagus and often involve esophagogastric junction. Radiotherapy plays a key role in ...
more infohttps://link.springer.com/protocol/10.1007/978-1-4939-7734-5_2
MOL] Adenocarcinoma [00265]  MOL] Adenocarcinoma [00265]
MOL] Adenocarcinoma. *To: "[email protected]" ,[email protected], ... My mother was diagnosed with Adenocarcinoma May 8 of the stomach. It has spread to her liver with "several" spots, a 5" tumor ...
more infohttp://www.meds.com/archive/mol-cancer/2000/06/msg00265.html
MOL] adenocarcinoma [00993]  MOL] adenocarcinoma [00993]
Recently a relative of my was diagnosed as having adenocarcinoma of the lung. I have been searching the WEB over and cannot ...
more infohttp://www.meds.com/archive/mol-cancer/1999/01/msg00993.html
kanefendt | Adenocarcinoma | BibSonomy  kanefendt | Adenocarcinoma | BibSonomy
AAdenocarcinomaAdenoviridaeAnimalsBALBBiologicalBurdenCC57BLCellCellsCulturedDiseaseEndothelialExperimentalFactorFemaleGenetic ... 80AdenocarcinomaAdultAgedAntibodiesCCellChemistryDDisease-FreeEndothelialFactorGrowthHumansImmunohistochemistryLaboratoriesLine ... 1AdenocarcinomaAutocrineBreastCCarcinomaCellColorectalCommunicationEndothelialExpressionFactorGeneGrowthHumanHumansHypoxia ... AAdenocarcinomaAnimalsAntibodiesBreastCarcinomaCellCellsCulturedDose-ResponseDown-RegulationDrugEndothelialEpidermalExpression ...
more infohttps://www.bibsonomy.org/user/kanefendt/Adenocarcinoma
Gastroesophageal Junction Adenocarcinoma Prognosis & Symptoms  Gastroesophageal Junction Adenocarcinoma Prognosis & Symptoms
Gastroesophageal junction adenocarcinoma is a type of cancer that forms in the glandular cells near the lower part of the ... Gastroesophageal Junction Adenocarcinoma. *Gastroesophageal junction adenocarcinoma facts. *What is gastroesophageal junction ... What are risk factors for gastroesophageal junction adenocarcinoma?. *What are gastroesophageal junction adenocarcinoma ... What are risk factors for gastroesophageal junction adenocarcinoma?. *What are gastroesophageal junction adenocarcinoma ...
more infohttps://www.medicinenet.com/gastroesophageal_junction_adenocarcinoma/article.htm
Adenocarcinoma  Adenocarcinoma
M8140/3 Adenocarcinoma is a cancer that originates in glandular ... Adenocarcinoma is a cancer that originates in glandular tissue ... Adenocarcinoma Adenocarcinoma, NOSClassification & external resources ICD-9 151.0, 182.0 ICD-O: ... The term adenocarcinoma is derived from adeno meaning pertaining to a gland and carcinoma, which describes a cancer that ... Adenomas/adenocarcinomas (8140-8429). Linitis plastica pancreas (Insulinoma, Glucagonoma, Gastrinoma, VIPoma, Somatostatinoma) ...
more infohttps://www.bionity.com/en/encyclopedia/Adenocarcinoma.html
Mucoid adenocarcinoma definition | Drugs.com  Mucoid adenocarcinoma definition | Drugs.com
Definition of mucoid adenocarcinoma. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... mucoid adenocarcinoma. Definition: sometimes applied to mucinous carcinoma, or adenocarcinoma containing mucin secreting ...
more infohttps://www.drugs.com/dict/mucoid-adenocarcinoma.html
  • Casali C, Rossi G, Marchioni A, Sartori G, Maselli F, Longo L, Tallarico E and Morandi U: A single institution-based retrospective study of surgically treated bronchioloalveolar adenocarcinoma of the lung: Clinicopathologic analysis, molecular features and possible pitfalls in routine practice. (spandidos-publications.com)
  • Although local recurrence on the wound after hemorrhoidectomy is not frequently seen, we encountered two patients with adenocarcinoma on the hemorrhoidectomy wound after hemorrhoidectomy. (springer.com)
  • Other morphologies include signet ring cell , which can diffusely spread into the bladder, and adenocarcinoma, not otherwise classifiable , or a mixed of these different patterns. (auanet.org)
  • Adenocarcinoma of the duodenum may arise from duodenal polyps observed in familial polyposis or Gardener's syndrome or be associated with celiac disease [ 3 , 4 ]. (hindawi.com)
  • Should always include metastasis or extension from an intestinal adenocarcinoma, before making the diagnosis. (auanet.org)
  • Urinalysis remains crucial in the diagnosis of adenocarcinoma of the kidneys, as it will provide important clues toward the final diagnosis. (petmd.com)
  • The purpose of this report is to describe perhaps the first case in the literature of iliopsoas metastasis from duodenal adenocarcinoma. (hindawi.com)
  • Common symptoms and signs of gastroesophageal adenocarcinoma include difficulty or pain with swallowing and unintentional weight loss . (medicinenet.com)
  • Several of the most common forms of cancer are adenocarcinomas, and the various sorts of adenocarcinoma vary greatly in all their aspects, so that few useful generalizations can be made about them. (wikipedia.org)
  • Adenocarcinoma cells do not necessarily need to be part of a gland but may possess secretory properties. (news-medical.net)
  • To be classified as adenocarcinoma, the cells do not necessarily need to be part of a gland , as long as they have secretory properties. (bionity.com)
  • The term adenocarcinoma is derived from 'adeno' meaning 'pertaining to a gland' and ' carcinoma ', which describes a cancer that has developed in the epithelial cells. (bionity.com)