Adenine Phosphoribosyltransferase: An enzyme catalyzing the formation of AMP from adenine and phosphoribosylpyrophosphate. It can act as a salvage enzyme for recycling of adenine into nucleic acids. EC 2.4.2.7.Hypoxanthine: A purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.Hypoxanthines: Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.UDPglucose-Hexose-1-Phosphate Uridylyltransferase: An enzyme that catalyzes the transfer of UMP from UDPglucose to galactose 1-phosphate, forming UDPgalactose and glucose 1-phosphate. Deficiency in this enzyme is the major cause of GALACTOSEMIA. EC 2.7.7.12.Galactosemias: A group of inherited enzyme deficiencies which feature elevations of GALACTOSE in the blood. This condition may be associated with deficiencies of GALACTOKINASE; UDPGLUCOSE-HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; or UDPGLUCOSE 4-EPIMERASE. The classic form is caused by UDPglucose-Hexose-1-Phosphate Uridylyltransferase deficiency, and presents in infancy with FAILURE TO THRIVE; VOMITING; and INTRACRANIAL HYPERTENSION. Affected individuals also may develop MENTAL RETARDATION; JAUNDICE; hepatosplenomegaly; ovarian failure (PRIMARY OVARIAN INSUFFICIENCY); and cataracts. (From Menkes, Textbook of Child Neurology, 5th ed, pp61-3)UTP-Hexose-1-Phosphate Uridylyltransferase: An enzyme that catalyzes the synthesis of UDPgalactose from UTP and galactose-1-phosphate. It is present in low levels in fetal and infant liver, but increases with age, thereby enabling galactosemic infants who survive to develop the capacity to metabolize galactose. EC 2.7.7.10.Phosphoribosyl Pyrophosphate: The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.Hypoxanthine Phosphoribosyltransferase: An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.Adenine: A purine base and a fundamental unit of ADENINE NUCLEOTIDES.Pentosyltransferases: Enzymes of the transferase class that catalyze the transfer of a pentose group from one compound to another.Thermus thermophilus: A species of gram-negative, aerobic, rod-shaped bacteria found in hot springs of neutral to alkaline pH, as well as in hot-water heaters.Thermus: Gram-negative aerobic rods found in warm water (40-79 degrees C) such as hot springs, hot water tanks, and thermally polluted rivers.Purines: A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.Orotate Phosphoribosyltransferase: The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the course of pyrimidine nucleotide biosynthesis. EC 2.4.2.10.Anthranilate Phosphoribosyltransferase: An enzyme that catalyzes the formation of N-5'-phosphoribosylanthranilic acid from anthranilate and phosphoribosylpyrophosphate, the first step in tryptophan synthesis in E. coli. It exists in a complex with ANTHRANILATE SYNTHASE in bacteria. EC 2.4.2.18.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.History, 18th Century: Time period from 1701 through 1800 of the common era.Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Drug Resistance, Bacterial: The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Ribose-Phosphate Pyrophosphokinase: An enzyme that catalyzes the formation of phosphoribosyl pyrophosphate from ATP and ribose-5-phosphate. EC 2.7.6.1.Purine Nucleotides: Purines attached to a RIBOSE and a phosphate that can polymerize to form DNA and RNA.Amidophosphoribosyltransferase: An enzyme, involved in the early steps of purine nucleotide biosynthesis, that catalyzes the formation of 5-phosphoribosylamine from glutamine and phosphoribosylpyrophosphate. EC 2.4.2.14.Uric Acid: An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.Phosphotransferases: A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.Ribosemonophosphates: Ribose substituted in the 1-, 3-, or 5-position by a phosphoric acid moiety.Purine-Pyrimidine Metabolism, Inborn ErrorsPoint Mutation: A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.5,10-Methylenetetrahydrofolate Reductase (FADH2): An FAD-dependent oxidoreductase found primarily in BACTERIA. It is specific for the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This enzyme was formerly listed as EC 1.1.1.68 and 1.1.99.15.Blood Gas Monitoring, Transcutaneous: The noninvasive measurement or determination of the partial pressure (tension) of oxygen and/or carbon dioxide locally in the capillaries of a tissue by the application to the skin of a special set of electrodes. These electrodes contain photoelectric sensors capable of picking up the specific wavelengths of radiation emitted by oxygenated versus reduced hemoglobin.Transcutaneous Electric Nerve Stimulation: The use of specifically placed small electrodes to deliver electrical impulses across the SKIN to relieve PAIN. It is used less frequently to produce ANESTHESIA.Disclosure: Revealing of information, by oral or written communication.Truth Disclosure: Truthful revelation of information, specifically when the information disclosed is likely to be psychologically painful ("bad news") to the recipient (e.g., revelation to a patient or a patient's family of the patient's DIAGNOSIS or PROGNOSIS) or embarrassing to the teller (e.g., revelation of medical errors).Administration, Cutaneous: The application of suitable drug dosage forms to the skin for either local or systemic effects.Lithotripsy: The destruction of a calculus of the kidney, ureter, bladder, or gallbladder by physical forces, including crushing with a lithotriptor through a catheter. Focused percutaneous ultrasound and focused hydraulic shock waves may be used without surgery. Lithotripsy does not include the dissolving of stones by acids or litholysis. Lithotripsy by laser is LITHOTRIPSY, LASER.Kidney Calculi: Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.Ureteral Calculi: Stones in the URETER that are formed in the KIDNEY. They are rarely more than 5 mm in diameter for larger renal stones cannot enter ureters. They are often lodged at the ureteral narrowing and can cause excruciating renal colic.High-Energy Shock Waves: High-amplitude compression waves, across which density, pressure, and particle velocity change drastically. The mechanical force from these shock waves can be used for mechanically disrupting tissues and deposits.Calculi: An abnormal concretion occurring mostly in the urinary and biliary tracts, usually composed of mineral salts. Also called stones.Nephrolithiasis: Formation of stones in the KIDNEY.Ureteroscopy: Endoscopic examination, therapy or surgery of the ureter.Urinary Calculi: Low-density crystals or stones in any part of the URINARY TRACT. Their chemical compositions often include CALCIUM OXALATE, magnesium ammonium phosphate (struvite), CYSTINE, or URIC ACID.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Calcium Oxalate: The calcium salt of oxalic acid, occurring in the urine as crystals and in certain calculi.
(1/221) Developmental changes in purine phosphoribosyltransferases in human and rat tissues.

1. The hypoxanthine/guanine and adenine phosphoribosyltransferase activities in a wide variety of human tissues were studied during their growth and development from foetal life onward. A wide range of activities develop after birth, with especially high values in the central nervous system and testes. 2. Postnatal development of hypoxanthine/guanine phosphoribosyltransferase was also defined in the rat. Although there were increases in the central nervous system and testes, there was also a rise in activity in the liver, which was less marked in man. 3. A sensitive radiochemical assay method, using dTTP to inhibit 5'-nucleotidase activity, suitable for tissue extracts, was developed. 4. No definite evidence of the existence of tissue-specific isoenzymes of hypoxanthine/guanine or adenine phosphoribosyltransferase was found. Hypoxanthine/guanine phosphoribosyltransferase in testes, however, had a significantly different thermal-denaturation rate constant. 5. The findings are discussed in an attempt to relate activity of hypoxanthine/guanine phosphoribosyltransferase to biological function. Growth as well as some developmental changes appear to be related to increase in the activity of this enzyme.  (+info)

(2/221) A novel signature mutation for oxidative damage resembles a mutational pattern found commonly in human cancers.

To determine the types of mutations induced by oxidative damage, a kidney cell line with a heterozygous deficiency for the autosomal Aprt (adenine phosphoribosyltransferase) gene was tested for its mutagenic response to hydrogen peroxide. Aprt-deficient cells were selected and scored for loss of heterozygosity (LOH) for 11 microsatellite loci on mouse chromosome 8. On the basis of the LOH analysis, spontaneous mutants (n = 38) were distributed into four classes: apparent point mutation, mitotic recombination, chromosome loss, and large interstitial deletion. However, 9 of 20 (45%) hydrogen peroxide-induced mutants exhibited a novel class of mutations characterized by "discontinuous LOH" for one or more of the microsatellite loci. Interestingly, mutations resembling discontinuous LOH are commonly observed in a wide variety of human cancers. Our data suggest that discontinuous LOH is a signature mutational pattern for oxidative damage and further suggest that such genetic damage is widespread in cancer.  (+info)

(3/221) Effect of interferon-gamma on purine catabolic and salvage enzyme activities in rats.

To determine whether interferon-gamma affects rat purine catabolic and salvage enzyme activities, rats were injected with interferon-gamma (600000 U/kg, i.p.) and, similarly to a vehicle-injected control group, killed before or after injection at 6, 12, and 24 h. Organ homogenates were prepared and enzymatic reactions with substrates were carried out, after which the products were measured either chromatographically or spectrophotometrically. Western and Northern blotting also were performed. In contrast to the vehicle-injected rats, interferon-gamma-injected rats showed a significant rise in xanthine oxidoreductase activity in the liver, while enzyme activity was unchanged in the spleen, kidney, and lung. Western analysis of hepatic xanthine oxidoreductase showed an increased concentration of this protein 12 and 24 h after interferon-gamma injection. Northern analysis disclosed an enhanced mRNA expression coding for this enzyme, peaking 12 h after injection. Contrastingly, the activities of adenosine deaminase, purine nucleoside phosphorylase, hypoxanthine guanine phosphoribosyltransferase, and adenine phosphoribosyltransferase were not affected by interferon-gamma in any organ tested. While interferon-gamma causes an increased hepatic biosynthesis of xanthine oxidoreductase, the physiologic role of this enzyme induction remains undetermined.  (+info)

(4/221) Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani.

The enzyme adenine phosphoribosyltransferase (APRT) functions to salvage adenine by converting it to adenosine-5-monophosphate (AMP). APRT deficiency in humans is a well characterized inborn error of metabolism, and APRT may contribute to the indispensable nutritional role of purine salvage in protozoan parasites, all of which lack de novo purine biosynthesis. We determined crystal structures for APRT from Leishmania donovani in complex with the substrate adenine, the product AMP, and sulfate and citrate ions that appear to mimic the binding of phosphate moieties. Overall, these structures are very similar to each other, although the adenine and AMP complexes show different patterns of hydrogen-bonding to the base, and the active site pocket opens slightly to accommodate the larger AMP ligand. Whereas AMP adopts a single conformation, adenine binds in two mutually exclusive orientations: one orientation providing adenine-specific hydrogen bonds and the other apparently positioning adenine for the enzymatic reaction. The core of APRT is similar to that of other phosphoribosyltransferases, although the adenine-binding domain is quite different. A C-terminal extension, unique to Leishmania APRTs, extends an extensive dimer interface by wrapping around the partner molecule. The active site involves residues from both subunits of the dimer, indicating that dimerization is essential for catalysis.  (+info)

(5/221) Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice.

Mice heterozygous at Aprt (adenine phosphoribosyltransferase) were used as a model to study in vivo loss of heterozygosity (LOH) in normal fibroblasts. Somatic cell variants that exhibited functional loss of the wild-type Aprt in vivo were recovered as APRT-deficient cell colonies after culturing in selection medium containing 2, 6-diaminopurine (DAP), an adenine analog that is toxic only to cells with APRT enzyme activity. DAP-resistant (DAP(r)) fibroblast variants were recovered at a median frequency of 12 x 10(-5) from individual ears from progeny of crosses between mouse strains 129/Sv and C3H/HeJ. The frequency of DAP(r) variants varied greatly among individual ears, suggesting that they preexisted in vivo and arose at various times during development. Polymorphic molecular markers and a cytological marker on the centromere of chromosome 8 made it possible to discriminate between each of six possible mechanistic pathways of LOH. The majority (about 80%) of the DAP(r) variants were a consequence of mitotic recombination. The prevalence of mitotic recombination in regions proximal to Aprt did not correlate with meiotic map distances. In particular, there was a higher than expected frequency of crossovers within the interval 59 cM to 67 cM. The high spontaneous frequency of Aprt LOH, mediated primarily by mitotic recombination, is fully consistent with our previous results with human peripheral T cells from individuals known to be heterozygous at APRT. Thus, this Aprt heterozygote mouse is a valid model for studying somatic mutagenesis and mitotic recombination in vivo.  (+info)

(6/221) Enhanced amsacrine-induced mutagenesis in plateau-phase Chinese hamster ovary cells, with targeting of +1 frameshifts to free 3' ends of topoisomerase II cleavable complexes.

Previous work showed that the DNA double-strand cleaving agents bleomycin and neocarzinostatin were more mutagenic in plateau-phase than in log-phase cells. To determine whether topoisomerase II poisons that produce double-strand breaks by trapping of cleavable complexes would, likewise, induce mutations specific to plateau-phase cells, aprt mutations induced by amsacrine in both log-phase and plateau-phase CHO cells were analyzed. The maximum aprt mutant frequencies obtained were 7 x 10(-6) after treatment with 0.02 microM amsacrine in log phase and 27 x 10(-6) after treatment with 1 microM amsacrine in plateau phase, compared with a spontaneous frequency of < 1 x 10(-6). Base substitutions dominated the spectrum of mutations in log-phase cells, but were much less prevalent in plateau-phase cells. Both spectra also included small deletions, insertions and duplications, as well as few large-scale deletions or rearrangements. About 5% of the log-phase mutants and 16% of the plateau-phase mutants were +1 frameshifts, and all but one of these were targeted to potential free 3' termini of cleavable complexes, as determined by mapping of cleavage sites in DNA treated with topoisomerase II plus amsacrine in vitro. Thus, these insertions may arise from templated extension of the exposed 3' terminus by a DNA polymerase, followed by resealing of the strand, as shown previously for acridine-induced frameshifts in T4 phage.  (+info)

(7/221) Solid tissues removed from ATM homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations.

The presence of increased frequencies of blood-derived and solid tumors in ataxia-telangiectasia (A-T) patients, coupled with a role for the ATM (A-T mutation) protein in detecting specific forms of DNA damage, has led to the assumption of a mutator phenotype in A TM-deficient cells. Supporting this assumption are observations of increased rates of chromosomal aberrations and intrachromosomal homologous recombinational events in the cells of A-T patients. We have bred mice with knockout mutations for the selectable Aprt (adenine phosphoribosyltransferase) locus and the Atm locus to examine the frequency of second-step autosomal mutations in Atm-deficient cells. Two solid tissues were examined: (a) the ear, which yields predominately mesenchymal cells; and (b) the kidney, which yields predominately epithelial cells. We report here the lack of a mutator phenotype for inactivating autosomal mutations in solid tissues of the Atm-deficient mice.  (+info)

(8/221) Localized Derepression on the Human Inactive X Chromosone in Mouse-Human Cell Hybrids.

Evidence for derepression of the gene for hypoxanthine phosphoribosyltransferase (HPRT; IMP: pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) on the human inactive X chromosome was obtained in hybrids of mouse and human cells. The mouse cells lacked HPRT and were also deficient in adenine phosphoribosyltransferase (APRT; AMP: pyrophosphate phosphoribosyltransferase; EC2.4.2.7). The human female fibroblasts were HPRT-deficient as a consequence of a mutation on the active X but contained a normal HPRT gene on the inactive X. The two human X chromosomes were further distinguished by differences in morphology: the inactive X was morphologically normal while the active X included most of the long arm of autosome no. 1 translocated to the distal end of the X long arm. Forty-one hybrid clones were first isolated by selection for the presence of APRT; when these clones were selected for HPRT, six of them yielded derivatives having human HPRT with incidences of about 1 in 10-6 APRT-selected hybrid cells. The HPRT-positive derivatives contained a normal-appearing X chromosome indistinguishable from the inactive X of the parental human fibroblasts. The active X with the translocation was not found in any of the HPRT-positive hybrid cells. Human phosphoglycerokinase (ATP:3-phospho-D-glycerate 1-phosphotransferase. EC 2.7.2.3) and glucose-6-phosphate dehydrogenase (D-glucose 6-phosphate: NADP 1-oxidoreductase, EC 1.1.1.49), which are specified by X-chromosomal loci, were not detected in the hybrids expressing HPRT even though they contained an apparently intact X chromosome. The observations are most simply explained by the infrequent, stable derepression of inactive X chromosome segments that include the HPRT locus but not the phosphoglycerokinase and glucose-6-phosphate dehydrogenase loci.  (+info)

*  Adenine phosphoribosyltransferase
"Adenine phosphoribosyltransferase isoforms of Arabidopsis and their potential contributions to adenine and cytokinin metabolism ... Adenine phosphoribosyltransferase (APRTase) is an enzyme encoded by the APRT gene, found in humans on chromosome 16. It is part ... Adenine phosphoribosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) Human APRT genome ... Takeuchi H, Kaneko Y, Fujita J, Yoshida O (Apr 1993). "A case of a compound heterozygote for adenine phosphoribosyltransferase ...
*  Adenine phosphoribosyltransferase deficiency
... at NIH's Office of Rare Diseases APRT at the Rare Kidney Stones Consortium. ... Adenine phosphoribosyltransferase deficiency (also called APRT deficiency or 2,8 dihydroxyadenine urolithiasis) is an autosomal ... Patients with the disease deficiency lack the enzyme adenine phosphoribosyltransferase and therefore have difficulties breaking ... Kamatani, N (December 1996). "Adenine phosphoribosyltransferase(APRT) deficiency" (Free full text). Nippon rinsho. Japanese ...
*  Allopurinol
... adenine phosphoribosyltransferase. It is also used to treat kidney stones caused by deficient activity of adenine ... hypoxanthine-guanine phosphoribosyltransferase, including Lesch-Nyhan syndrome; glucose 6-phosphatase including glycogen ... phosphoribosyltransferase. Allopurinol was also commonly used to treat tumor lysis syndrome in chemotherapeutic treatments, as ...
*  Purine metabolism
The enzyme adenine phosphoribosyltransferase (APRT) salvages adenine. The enzyme hypoxanthine-guanine phosphoribosyltransferase ... Both adenine and guanine are derived from the nucleotide inosine monophosphate (IMP), which is the first compound in the ...
*  Nucleic acid metabolism
For example, adenine + PRPP --> AMP + PPi. This reaction requires the enzyme adenine phosphoribosyltransferase. Free guanine is ... Adenine and guanine are the two nucleotides classified as purines. In purine synthesis, PRPP is turned into inosine ... Lesch-Nyhan syndrome is caused by a deficiency in hypoxanthine-guanine phosphoribosyltransferase or HGPRT, the enzyme that ... salvaged in the same way except it requires hypoxanthine-guanine phosphoribosyltransferase. Defects in purine catabolism can ...
*  Anton Yuryev
A Saccharomyces cerevisiae gene encoding a potential adenine phosphoribosyltransferase. Yeast 1994;10 (5): 659-662. Martin DR, ...
*  Phosphoribosyltransferase
Adenine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase Orotate phosphoribosyltransferase Uracil ... A phosphoribosyltransferase is a type of transferase enzyme. Types include: ...
*  Nucleotide salvage
There are two types of phosphoribosyltransferases: adenine phosphoribosyltransferase (APRT) and hypoxanthine-guanine ... Phosphoribosyltransferases add activated ribose-5-phosphate (Phosphoribosyl pyrophosphate, PRPP) to bases, creating nucleoside ... phosphoribosyltransferase (HGPRT). It is an important enzyme in Purine pathway metabolism. It is also involved in Lesch-Nyhan ...
*  2,8-Dihydroxyadenine
"Identification of two novel mutations in adenine phosphoribosyltransferase gene in patients with 2,8-dihydroxyadenine ... 2,8-Dihydroxyadenine is a derivative of adenine which accumulates in 2,8 dihydroxy-adenine urolithiasis. Diculescu, VC; Piedade ...
*  Pentosyltransferase
Examples include: adenine phosphoribosyltransferase hypoxanthine-guanine phosphoribosyltransferase pertussis toxin poly ADP ...
*  Glycosome
These enzymes found in the glycosome to help with synthesis are guanine and adenine phosphoribosyl transferase, hypoxanthine, ...
*  List of EC numbers (EC 2)
... adenine phosphoribosyltransferase EC 2.4.2.8: hypoxanthine phosphoribosyltransferase EC 2.4.2.9: uracil ... orotate phosphoribosyltransferase EC 2.4.2.11: now EC 6.3.4.21 EC 2.4.2.12: nicotinamide phosphoribosyltransferase EC 2.4.2.13 ... ATP phosphoribosyltransferase EC 2.4.2.18: anthranilate phosphoribosyltransferase EC 2.4.2.19: nicotinate-nucleotide ... nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase EC 2.4.2.22: xanthine phosphoribosyltransferase EC 2.4. ...
*  List of MeSH codes (D08)
... adenine phosphoribosyltransferase MeSH D08.811.913.400.725.115 --- adp ribose transferases MeSH D08.811.913.400.725.115.180 ... anthranilate phosphoribosyltransferase MeSH D08.811.913.400.725.200 --- ATP phosphoribosyltransferase MeSH D08.811.913.400. ... 725.450 --- hypoxanthine phosphoribosyltransferase MeSH D08.811.913.400.725.700 --- orotate phosphoribosyltransferase MeSH ... flavin-adenine dinucleotide MeSH D08.211.474.650.500 --- flavin mononucleotide MeSH D08.211.790.249 --- g(m2) activator protein ...
*  List of diseases (A)
... thumb club foot syndrome Adducted thumb syndrome recessive form Adducted thumbs Dundar type Adenine phosphoribosyltransferase ...
*  Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase
... adenine) phosphoribosyltransferase, nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase, and nicotinate ... In enzymology, a nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) is an enzyme that ... Other names in common use include CobT, nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase, nicotinate ... 6-dimethylbenzimidazole phosphoribosyltransferase responsible for the synthesis of N1-(5-phospho-alpha-D-ribosyl)-5,6- ...
*  Xanthine phosphoribosyltransferase
Their relationship to hypoxanthine and adenine phosphoribosyltransfer activities". J. Biol. Chem. 245 (10): 2605-11. PMID ... In enzymology, a xanthine phosphoribosyltransferase (EC 2.4.2.22) is an enzyme that catalyzes the chemical reaction XMP + ... Other names in common use include Xan phosphoribosyltransferase, xanthosine 5'-phosphate pyrophosphorylase, xanthylate ...
*  Nicotinamide phosphoribosyltransferase
Revollo JR, Grimm AA, Imai S (March 2007). "The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/ ... Nicotinamide phosphoribosyltransferase (NAmPRTase or Nampt) also known as pre-B-cell colony-enhancing factor 1 (PBEF1) or ... This protein is the rate-limiting enzyme in the Nicotinamide adenine dinucleotide (NAD+) salvage pathway that converts ... is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis". Eur. J. Immunol. 32 (11): 3225- ...
*  Calico (company)
... which plays a role in nicotinamide adenine dinucleotide biosynthesis. P7C3 compounds have previously been shown in a number of ... drug compounds P7C3 analogues involved in enhancing the activity of the enzyme nicotinamide phosphoribosyltransferase, ...
*  Hypoxanthine
Adenine Guanine Xanthine "Estimation of Plasmodium falciparum drug susceptibility by the 3H-hypoxanthine uptake inhibition ... Hypoxanthine-guanine phosphoribosyltransferase converts hypoxanthine into IMP in nucleotide salvage. Hypoxanthine is also a ... Because of its resemblance to guanine, the spontaneous deamination of adenine can lead to an error in DNA transcription/ ... including the DNA and RNA components adenine and guanine, may have been formed extraterrestrially in outer space. The Pheretima ...
*  Joseph Takahashi
In 2009, Joseph Bass in collaboration with Takahashi's group discovered that nicotinamide phosphoribosyltransferase (NAMPT) ... mediated synthesis of metabolic coenzyme nicotinamide adenine dinucleotide (NAD+), which both oscillate on a daily cycle, may ...
*  P7C3
The mechanism of action of the P7C3 series of compounds involves activation of nicotinamide phosphoribosyltransferase (NAMPT), ... the rate-limiting enzyme responsible for the transformation of nicotinamide into nicotinamide adenine dinucleotide (NAD). By ...
*  Uracil
The others are adenine (A), cytosine (C), and guanine (G). In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the ... Uracil also recycles itself to form nucleotides by undergoing a series of phosphoribosyltransferase reactions. Degradation of ... Uracil pairs with adenine through hydrogen bonding. When base pairing with adenine, uracil acts as both a hydrogen bond ... In RNA, uracil base-pairs with adenine and replaces thymine during DNA transcription. Methylation of uracil produces thymine. ...
*  Purine riboswitch
The add adenine riboswitch has shown three distinct stable confirmations in the presence of adenine. When unbound to adenine, ... The xpt gene encodes a specific xanthine phosphoribosyltransferase protein, which is involved in purine metabolism. Unlike the ... The Adenine Riboswitch selectively recognizes adenine, and contains a uracil ribonucleotide in position 74 of the adenine- ... In this way, an abundance of adenine can instigate the process of adenine's efflux from a cell. Unlike the add adenine ...
*  Lesch-Nyhan syndrome
The purine bases (adenine and guanine) and pyrimidine bases (thymine and cytosine) are bound to deoxyribose and phosphate and ... In Lesch-Nyhan syndrome, the defective gene is that for hypoxanthine-guanine phosphoribosyltransferase (HPRT), a participant in ... so named because it codes for the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT or HGPRT, EC 2.4.2.8). This ... is a rare inherited disorder caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT), ...
*  Nucleotide
The purine bases adenine and guanine and pyrimidine base cytosine occur in both DNA and RNA, while the pyrimidine bases thymine ... Orotate phosphoribosyltransferase (PRPP transferase) catalyzes the net reaction yielding orotidine monophosphate (OMP): Orotate ... Adenine forms a base pair with thymine with two hydrogen bonds, while guanine pairs with cytosine with three hydrogen bonds. ... Inosine occurs in tRNAs, and will pair with adenine, cytosine, or thymine. This character does not appear in the following ...
Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Activation of the Antiviral Agent T-705 (favipiravir) |...  Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Activation of the Antiviral Agent T-705 (favipiravir) |...
Knockdown for adenine phosphoribosyltransferase (APRT) or nicotinamide phosphoribosyltransferase did not change the antiviral ... Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Activation of the Antiviral Agent T-705 (favipiravir). Lieve ... Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Activation of the Antiviral Agent T-705 (favipiravir). Lieve ... Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Activation of the Antiviral Agent T-705 (favipiravir). Lieve ...
more infohttp://molpharm.aspetjournals.org/content/early/2013/08/01/mol.113.087247
APRT adenine phosphoribosyltransferase [Homo sapiens (human)] - Gene - NCBI  APRT adenine phosphoribosyltransferase [Homo sapiens (human)] - Gene - NCBI
Adenine phosphoribosyltransferase deficiency MedGen: C0268120 OMIM: 614723 GeneReviews: Adenine Phosphoribosyltransferase ... APRT adenine phosphoribosyltransferase [Homo sapiens] APRT adenine phosphoribosyltransferase [Homo sapiens]. Gene ID:353 ... was found in a patient with adenine phosphoribosyltransferase deficiency. Title: Adenine phosphoribosyltransferase (APRT) ... Adenine Phosphoribosyltransferase Deficiency Edvardsson VO, et al. , 1993. PMID 22934314 * A Japanese boy with adenine ...
more infohttps://www.ncbi.nlm.nih.gov/gene/353
Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis | PNAS  Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis | PNAS
Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. S J Engle, M G Stockelman, J ... Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. S J Engle, M G Stockelman, J ... Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. S J Engle, M G Stockelman, J ... Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis Message Subject (Your Name) has ...
more infohttps://www.pnas.org/content/93/11/5307?ijkey=1215662c1bbcca393344a110cd65a47ad523f985&keytype2=tf_ipsecsha
anti-Adenine Phosphoribosyltransferase Primary Antibodies  anti-Adenine Phosphoribosyltransferase Primary Antibodies
Adenine Phosphoribosyltransferase (APRT) Antigen-Profil Beschreibung des Gens Adenine phosphoribosyltransferase belongs to the ... Weitere Produktkategorien zu Adenine Phosphoribosyltransferase Antikörper * 93 anti-Adenine Phosphoribosyltransferase Primary ... anti-Adenine Phosphoribosyltransferase (APRT) Antikörper. Bezeichnung:. anti-Adenine Phosphoribosyltransferase Antikörper (APRT ... Am meisten referenzierte anti-Adenine Phosphoribosyltransferase Antikörper. Show all anti-Adenine Phosphoribosyltransferase ( ...
more infohttps://www.antikoerper-online.de/ribonucleoside-biosynthetic-process-pathway-82/aprt-antibody-12383/
Adenine phosphoribosyltransferase deficiency - Genetics Home Reference - NIH  Adenine phosphoribosyltransferase deficiency - Genetics Home Reference - NIH
MalaCards: adenine phosphoribosyltransferase deficiency. *Merck Manual for Patients and Caregivers: Stones in the Urinary Tract ... Adenine phosphoribosyltransferase (APRT) deficiency is an inherited condition that affects the kidneys and urinary tract. The ... Adenine phosphoribosyltransferase deficiency in children. Pediatr Nephrol. 2012 Apr;27(4):571-9. doi: 10.1007/s00467-011-2037-0 ... Bollée G, Harambat J, Bensman A, Knebelmann B, Daudon M, Ceballos-Picot I. Adenine phosphoribosyltransferase deficiency. Clin J ...
more infohttps://ghr.nlm.nih.gov/condition/adenine-phosphoribosyltransferase-deficiency
Adenine phosphoribosyltransferase - Wikipedia  Adenine phosphoribosyltransferase - Wikipedia
"Adenine phosphoribosyltransferase isoforms of Arabidopsis and their potential contributions to adenine and cytokinin metabolism ... Adenine phosphoribosyltransferase (APRTase) is an enzyme encoded by the APRT gene, found in humans on chromosome 16. It is part ... Adenine phosphoribosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) Human APRT genome ... Takeuchi H, Kaneko Y, Fujita J, Yoshida O (Apr 1993). "A case of a compound heterozygote for adenine phosphoribosyltransferase ...
more infohttps://en.wikipedia.org/wiki/Adenine_phosphoribosyltransferase
Adenine phosphoribosyltransferase deficiency - Wikipedia  Adenine phosphoribosyltransferase deficiency - Wikipedia
Adenine phosphoribosyltransferase deficiency at NIH's Office of Rare Diseases APRT at the Rare Kidney Stones Consortium. ... Adenine phosphoribosyltransferase deficiency (also called APRT deficiency or 2,8 dihydroxyadenine urolithiasis) is an autosomal ... Patients with the disease deficiency lack the enzyme adenine phosphoribosyltransferase and therefore have difficulties breaking ... Kamatani, N (December 1996). "Adenine phosphoribosyltransferase(APRT) deficiency" (Free full text). Nippon rinsho. Japanese ...
more infohttps://en.wikipedia.org/wiki/Adenine_phosphoribosyltransferase_deficiency
Recombinant Human Adenine phosphoribosyltransferase APRT-1939H - Creative BioMart  Recombinant Human Adenine phosphoribosyltransferase APRT-1939H - Creative BioMart
APRT adenine phosphoribosyltransferase [ Homo sapiens ]. Synonyms:. APRT; adenine phosphoribosyltransferase; AMP; MGC125856; ... AMP binding; adenine binding; adenine phosphoribosyltransferase activity; protein binding; transferase activity, transferring ... Recombinant Human Adenine phosphoribosyltransferase. Download Datasheet See All APRT Products. Bring this labeled protein ... APRT (adenine phosphoribosyltransferase) is a 180 amino acid protein that localizes to the cytoplasm and belongs to the purine/ ...
more infohttps://www.creativebiomart.net/description_7252_14.htm
Adenine phosphoribosyltransferase elisa and antibody  Adenine phosphoribosyltransferase elisa and antibody
Recombinant Protein and Adenine phosphoribosyltransferase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and ... Adenine phosphoribosyltransferase. Adenine phosphoribosyltransferase ELISA Kit. Adenine phosphoribosyltransferase Recombinant. ... Adenine phosphoribosyltransferase 1. Adenine phosphoribosyltransferase 1 ELISA Kit. Adenine phosphoribosyltransferase 1 ... Adenine phosphoribosyltransferase 2. Adenine phosphoribosyltransferase 2 ELISA Kit. Adenine phosphoribosyltransferase 2 ...
more infohttps://www.mybiosource.com/proteins-family/adenine-phosphoribosyltransferase
Adenine phosphoribosyltransferase elisa and antibody  Adenine phosphoribosyltransferase elisa and antibody
Recombinant Protein and Adenine phosphoribosyltransferase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and ... Adenine phosphoribosyltransferase. Adenine phosphoribosyltransferase ELISA Kit. Adenine phosphoribosyltransferase Recombinant. ... Adenine phosphoribosyltransferase 1. Adenine phosphoribosyltransferase 1 ELISA Kit. Adenine phosphoribosyltransferase 1 ... Adenine phosphoribosyltransferase 2. Adenine phosphoribosyltransferase 2 ELISA Kit. Adenine phosphoribosyltransferase 2 ...
more infohttps://www.mybiosource.com/protein_family.php?root=adenine-phosphoribosyltransferase
Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend...  Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend...
Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend ... Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend ... Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend ... Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend ...
more infohttp://www.biochemsoctrans.org/content/18/4/618.1
Cloning of a functional human adenine phosphoribosyltransferase (APRT) gene: identification of a restriction fragment length...  Cloning of a functional human adenine phosphoribosyltransferase (APRT) gene: identification of a restriction fragment length...
Identification of a splice mutation at the adenine phosphoribosyltransferase locus in a German family. *Birgit S. Gathof, Amrik ... A complete cDNA for adenine phosphoribosyltransferase fromArabidopsis thaliana. *Barbara A. Moffatt, Elizabeth Mcwhinnie, ... The origin of the most common mutation of adenine phosphoribosyltransferase among Japanese goes back to a prehistoric era. * ... Intervention of somatic mutational events in vivo by a germline defect at the adenine phosphoribosyltransferase locus. * ...
more infohttps://www.semanticscholar.org/paper/Cloning-of-a-functional-human-adenine-%28APRT%29-gene%3A-Stambrook-Dush/650836cee44dc401d1a16ddf6de6c10799951edf
anti-Adenine Phosphoribosyltransferase Primary Antibodies  anti-Adenine Phosphoribosyltransferase Primary Antibodies
Adenine Phosphoribosyltransferase (APRT) profil antigène Antigen Summary Adenine phosphoribosyltransferase belongs to the ... De plus, nous expédions Adenine Phosphoribosyltransferase Protéines (18) et Adenine Phosphoribosyltransferase Kits (11) et ... Alternative names and synonyms associated with Adenine Phosphoribosyltransferase (APRT) * adenine phosphoribosyltransferase ( ... anti-Adenine Phosphoribosyltransferase Anticorps (APRT). Chez www.anticorps-enligne.fr sont 101 Adenine ...
more infohttps://www.anticorps-enligne.fr/ribonucleoside-biosynthetic-process-pathway-82/aprt-antibody-12383/
No questions in Adenine Phosphoribosyltransferase - lookformedical.com  No questions in Adenine Phosphoribosyltransferase - lookformedical.com
It can act as a salvage enzyme for recycling of adenine into nucleic acids. EC 2.4.2.7. ... An enzyme catalyzing the formation of AMP from adenine and phosphoribosylpyrophosphate. ...
more infohttps://lookformedical.com/answers/en/chemicals-and-drugs/enzymes-and-coenzymes/enzymes/transferases/glycosyltransferases/pentosyltransferases/adenine-phosphoribosyltransferase
List of variants studied for adenine phosphoribosyltransferase deficiency by OMIM -
            ClinVar Miner  List of variants studied for adenine phosphoribosyltransferase deficiency by OMIM - ClinVar Miner
List of variants studied for adenine phosphoribosyltransferase deficiency by OMIM Included ClinVar conditions (1):*Adenine ...
more infohttps://clinvarminer.genetics.utah.edu/variants-by-mondo-condition/13869/submitter/3
Cloning, expression and biochemical characterization of xanthine and adenine phosphoribosyltransferases from thermus...  Cloning, expression and biochemical characterization of xanthine and adenine phosphoribosyltransferases from thermus...
... one-step synthesis of some purine NMPs using xanthine phosphoribosyltransferase, XPRT or adenine phosphoribosyltransferase, ... Cloning, expression and biochemical characterization of xanthine and adenine phosphoribosyltransferases from thermus ... Cloning, expression and biochemical characterization of xanthine and adenine phosphoribosyltransferases from thermus ... Purine phosphoribosyltransferases, purine PRTs, are essential enzymes in the purine salvage pathway of living organisms. They ...
more infohttp://abacus.universidadeuropea.es/handle/11268/6505
Corrigendum to Quantitative UPLC-MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine...  Corrigendum to "Quantitative UPLC-MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine...
Adenine phosphoribosyltransferase deficiency: a case diagnosed by GC-MS identification of 2,8-dihydroxyadenine in urinary ... Adenine phosphoribosyltransferase deficiency identified by urinary sediment analysis: cellular and molecular confirmation. ... Quantitative UPLC-MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase ... Two cases of 2.8-dihydroxyadenine stone with a partial deficiency of adenine phosphoribosyltransferase]. ...
more infohttps://www.hirsla.lsh.is/handle/2336/620679
SWISS-MODEL Repository | Q24UQ1  SWISS-MODEL Repository | Q24UQ1
Adenine phosphoribosyltransferase UniProtKBInterProSTRINGInteractive Modelling. 173 aa; Sequence (Fasta) It is possible new ...
more infohttps://swissmodel.expasy.org/repository/uniprot/Q24UQ1
RKSC > Healthcare Professionals > Disease...  RKSC > Healthcare Professionals > Disease...
Adenine Phosphoribosyltransferase (APRT) Deficiency. What is Adenine Phosphoribosyltransferase Deficiency?. Adenine ... How is Adenine Phosphoribosyltransferase Deficiency treated?. Allopurinol, when administered in the dose of 5-10 mg/kg/day ( ... How is Adenine Phosphoribosyltransferase Deficiency diagnosed?. The diagnosis of APRT deficiency is simple because the typical ... Epidemiology of Adenine Phosphoribosyltransferase Deficiency. The estimated prevalence is 0.5 to 1 per 100,000 in the Caucasian ...
more infohttps://www.rarediseasesnetwork.org/cms/rksc/Healthcare-Professionals/Disease-Definitions
  • Both adenine and guanine are derived from the nucleotide inosine monophosphate (IMP), which is synthesised on a pre-existing ribose-phosphate through a complex pathway using atoms from the amino acids glycine, glutamine, and aspartic acid, as well as formate ions transferred from the coenzyme tetrahydrofolate . (wikibooks.org)
  • The hood, which contains the adenine binding site, has more variability within the family of enzymes. (wikipedia.org)
  • In parasitic protozoa such as giardia, APRTase provides the sole mechanism by which adenine can be produced. (wikipedia.org)