Adenine Phosphoribosyltransferase: An enzyme catalyzing the formation of AMP from adenine and phosphoribosylpyrophosphate. It can act as a salvage enzyme for recycling of adenine into nucleic acids. EC 2.4.2.7.Pentosyltransferases: Enzymes of the transferase class that catalyze the transfer of a pentose group from one compound to another.Hypoxanthine Phosphoribosyltransferase: An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.Adenine: A purine base and a fundamental unit of ADENINE NUCLEOTIDES.Hypoxanthines: Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.Phosphoribosyl Pyrophosphate: The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.Orotate Phosphoribosyltransferase: The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the course of pyrimidine nucleotide biosynthesis. EC 2.4.2.10.Chromosomes, Human, 16-18: The short, submetacentric human chromosomes, called group E in the human chromosome classification. This group consists of chromosome pairs 16, 17, and 18.Nicotinamide Phosphoribosyltransferase: An enzyme that catalyzes the formation of nicotinamide mononucleotide (NMN) from nicotinamide and 5-phosphoribosyl-1-pyrophosphate, the rate-limiting step in the biosynthesis of the NAD coenzyme. It is also known as a growth factor for early B-LYMPHOCYTES, or an ADIPOKINE with insulin-mimetic effects (visfatin).Azaserine: Antibiotic substance produced by various Streptomyces species. It is an inhibitor of enzymatic activities that involve glutamine and is used as an antineoplastic and immunosuppressive agent.Purines: A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)PentosephosphatesATP Phosphoribosyltransferase: An enzyme that catalyzes the first step of the pathway for histidine biosynthesis in Salmonella typhimurium. ATP reacts reversibly with 5-phosphoribosyl-1-pyrophosphate to yield N-1-(5'-phosphoribosyl)-ATP and pyrophosphate. EC 2.4.2.17.Purine-Nucleoside Phosphorylase: An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free purine plus ribose-5-phosphate. EC 2.4.2.1.Carcinoma, Ehrlich Tumor: A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.Anthranilate Phosphoribosyltransferase: An enzyme that catalyzes the formation of N-5'-phosphoribosylanthranilic acid from anthranilate and phosphoribosylpyrophosphate, the first step in tryptophan synthesis in E. coli. It exists in a complex with ANTHRANILATE SYNTHASE in bacteria. EC 2.4.2.18.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Nucleotides: The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Heterozygote Detection: Identification of genetic carriers for a given trait.Hybrid Cells: Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Azaguanine: One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.Purine-Pyrimidine Metabolism, Inborn ErrorsCricetulus: A genus of the family Muridae consisting of eleven species. C. migratorius, the grey or Armenian hamster, and C. griseus, the Chinese hamster, are the two species used in biomedical research.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Blotting, Southern: A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.Glucosyltransferases: Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.Kinetics: The rate dynamics in chemical or physical systems.Adenine NucleotidesDNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).CHO Cells: CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Acrylamides: Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.Nicotinamide Mononucleotide: 3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose. Synonyms: Nicotinamide Ribonucleotide; NMN.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Hypoxanthine: A purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.UDPglucose-Hexose-1-Phosphate Uridylyltransferase: An enzyme that catalyzes the transfer of UMP from UDPglucose to galactose 1-phosphate, forming UDPgalactose and glucose 1-phosphate. Deficiency in this enzyme is the major cause of GALACTOSEMIA. EC 2.7.7.12.Galactosemias: A group of inherited enzyme deficiencies which feature elevations of GALACTOSE in the blood. This condition may be associated with deficiencies of GALACTOKINASE; UDPGLUCOSE-HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; or UDPGLUCOSE 4-EPIMERASE. The classic form is caused by UDPglucose-Hexose-1-Phosphate Uridylyltransferase deficiency, and presents in infancy with FAILURE TO THRIVE; VOMITING; and INTRACRANIAL HYPERTENSION. Affected individuals also may develop MENTAL RETARDATION; JAUNDICE; hepatosplenomegaly; ovarian failure (PRIMARY OVARIAN INSUFFICIENCY); and cataracts. (From Menkes, Textbook of Child Neurology, 5th ed, pp61-3)UTP-Hexose-1-Phosphate Uridylyltransferase: An enzyme that catalyzes the synthesis of UDPgalactose from UTP and galactose-1-phosphate. It is present in low levels in fetal and infant liver, but increases with age, thereby enabling galactosemic infants who survive to develop the capacity to metabolize galactose. EC 2.7.7.10.Lithotripsy: The destruction of a calculus of the kidney, ureter, bladder, or gallbladder by physical forces, including crushing with a lithotriptor through a catheter. Focused percutaneous ultrasound and focused hydraulic shock waves may be used without surgery. Lithotripsy does not include the dissolving of stones by acids or litholysis. Lithotripsy by laser is LITHOTRIPSY, LASER.Kidney Calculi: Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.Ureteral Calculi: Stones in the URETER that are formed in the KIDNEY. They are rarely more than 5 mm in diameter for larger renal stones cannot enter ureters. They are often lodged at the ureteral narrowing and can cause excruciating renal colic.High-Energy Shock Waves: High-amplitude compression waves, across which density, pressure, and particle velocity change drastically. The mechanical force from these shock waves can be used for mechanically disrupting tissues and deposits.Calculi: An abnormal concretion occurring mostly in the urinary and biliary tracts, usually composed of mineral salts. Also called stones.Nephrolithiasis: Formation of stones in the KIDNEY.Ureteroscopy: Endoscopic examination, therapy or surgery of the ureter.
Developmental changes in purine phosphoribosyltransferases in human and rat tissues. (1/221)
1. The hypoxanthine/guanine and adenine phosphoribosyltransferase activities in a wide variety of human tissues were studied during their growth and development from foetal life onward. A wide range of activities develop after birth, with especially high values in the central nervous system and testes. 2. Postnatal development of hypoxanthine/guanine phosphoribosyltransferase was also defined in the rat. Although there were increases in the central nervous system and testes, there was also a rise in activity in the liver, which was less marked in man. 3. A sensitive radiochemical assay method, using dTTP to inhibit 5'-nucleotidase activity, suitable for tissue extracts, was developed. 4. No definite evidence of the existence of tissue-specific isoenzymes of hypoxanthine/guanine or adenine phosphoribosyltransferase was found. Hypoxanthine/guanine phosphoribosyltransferase in testes, however, had a significantly different thermal-denaturation rate constant. 5. The findings are discussed in an attempt to relate activity of hypoxanthine/guanine phosphoribosyltransferase to biological function. Growth as well as some developmental changes appear to be related to increase in the activity of this enzyme. (+info)A novel signature mutation for oxidative damage resembles a mutational pattern found commonly in human cancers. (2/221)
To determine the types of mutations induced by oxidative damage, a kidney cell line with a heterozygous deficiency for the autosomal Aprt (adenine phosphoribosyltransferase) gene was tested for its mutagenic response to hydrogen peroxide. Aprt-deficient cells were selected and scored for loss of heterozygosity (LOH) for 11 microsatellite loci on mouse chromosome 8. On the basis of the LOH analysis, spontaneous mutants (n = 38) were distributed into four classes: apparent point mutation, mitotic recombination, chromosome loss, and large interstitial deletion. However, 9 of 20 (45%) hydrogen peroxide-induced mutants exhibited a novel class of mutations characterized by "discontinuous LOH" for one or more of the microsatellite loci. Interestingly, mutations resembling discontinuous LOH are commonly observed in a wide variety of human cancers. Our data suggest that discontinuous LOH is a signature mutational pattern for oxidative damage and further suggest that such genetic damage is widespread in cancer. (+info)Effect of interferon-gamma on purine catabolic and salvage enzyme activities in rats. (3/221)
To determine whether interferon-gamma affects rat purine catabolic and salvage enzyme activities, rats were injected with interferon-gamma (600000 U/kg, i.p.) and, similarly to a vehicle-injected control group, killed before or after injection at 6, 12, and 24 h. Organ homogenates were prepared and enzymatic reactions with substrates were carried out, after which the products were measured either chromatographically or spectrophotometrically. Western and Northern blotting also were performed. In contrast to the vehicle-injected rats, interferon-gamma-injected rats showed a significant rise in xanthine oxidoreductase activity in the liver, while enzyme activity was unchanged in the spleen, kidney, and lung. Western analysis of hepatic xanthine oxidoreductase showed an increased concentration of this protein 12 and 24 h after interferon-gamma injection. Northern analysis disclosed an enhanced mRNA expression coding for this enzyme, peaking 12 h after injection. Contrastingly, the activities of adenosine deaminase, purine nucleoside phosphorylase, hypoxanthine guanine phosphoribosyltransferase, and adenine phosphoribosyltransferase were not affected by interferon-gamma in any organ tested. While interferon-gamma causes an increased hepatic biosynthesis of xanthine oxidoreductase, the physiologic role of this enzyme induction remains undetermined. (+info)Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani. (4/221)
The enzyme adenine phosphoribosyltransferase (APRT) functions to salvage adenine by converting it to adenosine-5-monophosphate (AMP). APRT deficiency in humans is a well characterized inborn error of metabolism, and APRT may contribute to the indispensable nutritional role of purine salvage in protozoan parasites, all of which lack de novo purine biosynthesis. We determined crystal structures for APRT from Leishmania donovani in complex with the substrate adenine, the product AMP, and sulfate and citrate ions that appear to mimic the binding of phosphate moieties. Overall, these structures are very similar to each other, although the adenine and AMP complexes show different patterns of hydrogen-bonding to the base, and the active site pocket opens slightly to accommodate the larger AMP ligand. Whereas AMP adopts a single conformation, adenine binds in two mutually exclusive orientations: one orientation providing adenine-specific hydrogen bonds and the other apparently positioning adenine for the enzymatic reaction. The core of APRT is similar to that of other phosphoribosyltransferases, although the adenine-binding domain is quite different. A C-terminal extension, unique to Leishmania APRTs, extends an extensive dimer interface by wrapping around the partner molecule. The active site involves residues from both subunits of the dimer, indicating that dimerization is essential for catalysis. (+info)Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice. (5/221)
Mice heterozygous at Aprt (adenine phosphoribosyltransferase) were used as a model to study in vivo loss of heterozygosity (LOH) in normal fibroblasts. Somatic cell variants that exhibited functional loss of the wild-type Aprt in vivo were recovered as APRT-deficient cell colonies after culturing in selection medium containing 2, 6-diaminopurine (DAP), an adenine analog that is toxic only to cells with APRT enzyme activity. DAP-resistant (DAP(r)) fibroblast variants were recovered at a median frequency of 12 x 10(-5) from individual ears from progeny of crosses between mouse strains 129/Sv and C3H/HeJ. The frequency of DAP(r) variants varied greatly among individual ears, suggesting that they preexisted in vivo and arose at various times during development. Polymorphic molecular markers and a cytological marker on the centromere of chromosome 8 made it possible to discriminate between each of six possible mechanistic pathways of LOH. The majority (about 80%) of the DAP(r) variants were a consequence of mitotic recombination. The prevalence of mitotic recombination in regions proximal to Aprt did not correlate with meiotic map distances. In particular, there was a higher than expected frequency of crossovers within the interval 59 cM to 67 cM. The high spontaneous frequency of Aprt LOH, mediated primarily by mitotic recombination, is fully consistent with our previous results with human peripheral T cells from individuals known to be heterozygous at APRT. Thus, this Aprt heterozygote mouse is a valid model for studying somatic mutagenesis and mitotic recombination in vivo. (+info)Enhanced amsacrine-induced mutagenesis in plateau-phase Chinese hamster ovary cells, with targeting of +1 frameshifts to free 3' ends of topoisomerase II cleavable complexes. (6/221)
Previous work showed that the DNA double-strand cleaving agents bleomycin and neocarzinostatin were more mutagenic in plateau-phase than in log-phase cells. To determine whether topoisomerase II poisons that produce double-strand breaks by trapping of cleavable complexes would, likewise, induce mutations specific to plateau-phase cells, aprt mutations induced by amsacrine in both log-phase and plateau-phase CHO cells were analyzed. The maximum aprt mutant frequencies obtained were 7 x 10(-6) after treatment with 0.02 microM amsacrine in log phase and 27 x 10(-6) after treatment with 1 microM amsacrine in plateau phase, compared with a spontaneous frequency of < 1 x 10(-6). Base substitutions dominated the spectrum of mutations in log-phase cells, but were much less prevalent in plateau-phase cells. Both spectra also included small deletions, insertions and duplications, as well as few large-scale deletions or rearrangements. About 5% of the log-phase mutants and 16% of the plateau-phase mutants were +1 frameshifts, and all but one of these were targeted to potential free 3' termini of cleavable complexes, as determined by mapping of cleavage sites in DNA treated with topoisomerase II plus amsacrine in vitro. Thus, these insertions may arise from templated extension of the exposed 3' terminus by a DNA polymerase, followed by resealing of the strand, as shown previously for acridine-induced frameshifts in T4 phage. (+info)Solid tissues removed from ATM homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations. (7/221)
The presence of increased frequencies of blood-derived and solid tumors in ataxia-telangiectasia (A-T) patients, coupled with a role for the ATM (A-T mutation) protein in detecting specific forms of DNA damage, has led to the assumption of a mutator phenotype in A TM-deficient cells. Supporting this assumption are observations of increased rates of chromosomal aberrations and intrachromosomal homologous recombinational events in the cells of A-T patients. We have bred mice with knockout mutations for the selectable Aprt (adenine phosphoribosyltransferase) locus and the Atm locus to examine the frequency of second-step autosomal mutations in Atm-deficient cells. Two solid tissues were examined: (a) the ear, which yields predominately mesenchymal cells; and (b) the kidney, which yields predominately epithelial cells. We report here the lack of a mutator phenotype for inactivating autosomal mutations in solid tissues of the Atm-deficient mice. (+info)Localized Derepression on the Human Inactive X Chromosone in Mouse-Human Cell Hybrids. (8/221)
Evidence for derepression of the gene for hypoxanthine phosphoribosyltransferase (HPRT; IMP: pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) on the human inactive X chromosome was obtained in hybrids of mouse and human cells. The mouse cells lacked HPRT and were also deficient in adenine phosphoribosyltransferase (APRT; AMP: pyrophosphate phosphoribosyltransferase; EC2.4.2.7). The human female fibroblasts were HPRT-deficient as a consequence of a mutation on the active X but contained a normal HPRT gene on the inactive X. The two human X chromosomes were further distinguished by differences in morphology: the inactive X was morphologically normal while the active X included most of the long arm of autosome no. 1 translocated to the distal end of the X long arm. Forty-one hybrid clones were first isolated by selection for the presence of APRT; when these clones were selected for HPRT, six of them yielded derivatives having human HPRT with incidences of about 1 in 10-6 APRT-selected hybrid cells. The HPRT-positive derivatives contained a normal-appearing X chromosome indistinguishable from the inactive X of the parental human fibroblasts. The active X with the translocation was not found in any of the HPRT-positive hybrid cells. Human phosphoglycerokinase (ATP:3-phospho-D-glycerate 1-phosphotransferase. EC 2.7.2.3) and glucose-6-phosphate dehydrogenase (D-glucose 6-phosphate: NADP 1-oxidoreductase, EC 1.1.1.49), which are specified by X-chromosomal loci, were not detected in the hybrids expressing HPRT even though they contained an apparently intact X chromosome. The observations are most simply explained by the infrequent, stable derepression of inactive X chromosome segments that include the HPRT locus but not the phosphoglycerokinase and glucose-6-phosphate dehydrogenase loci. (+info)... adenine phosphoribosyltransferase. It is also used to treat kidney stones caused by deficient activity of adenine ... hypoxanthine-guanine phosphoribosyltransferase, including Lesch-Nyhan syndrome; glucose 6-phosphatase including glycogen ... phosphoribosyltransferase. Allopurinol was also commonly used to treat tumor lysis syndrome in chemotherapeutic treatments, as ...
adenine. adenine phosphoribosyltransferase (APRT). AMP Folate biosynthesis[edit]. Tetrahydrofolic acid and its derivatives are ... There are two types of phosphoribosyltransferases: adenine phosphoribosyltransferase (APRT) and hypoxanthine-guanine ... hypoxanthine/guanine phosphoribosyl transferase (HGPRT). IMP guanine. hypoxanthine/guanine phosphoribosyl transferase (HGPRT). ... Phosphoribosyltransferases add activated ribose-5-phosphate (Phosphoribosyl pyrophosphate, PRPP) to bases, creating nucleoside ...
Kamatani, N (1996). "Adenine phosphoribosyltransferase (APRT) deficiency". Nippon Rinsho. Japanese Journal of Clinical Medicine ... People afflicted with adenine phosphoribosyltransferase deficiency may produce 2,8-dihydroxyadenine stones,[62] alkaptonurics ...
The enzyme adenine phosphoribosyltransferase (APRT) salvages adenine. The enzyme hypoxanthine-guanine phosphoribosyltransferase ... Both adenine and guanine are derived from the nucleotide inosine monophosphate (IMP), which is the first compound in the ...
For example, adenine + PRPP --> AMP + PPi. This reaction requires the enzyme adenine phosphoribosyltransferase. Free guanine is ... Adenine and guanine are the two nucleotides classified as purines. In purine synthesis, PRPP is turned into inosine ... Lesch-Nyhan syndrome is caused by a deficiency in hypoxanthine-guanine phosphoribosyltransferase or HGPRT, the enzyme that ... salvaged in the same way except it requires hypoxanthine-guanine phosphoribosyltransferase. Defects in purine catabolism can ...
A Saccharomyces cerevisiae gene encoding a potential adenine phosphoribosyltransferase. Yeast 1994;10 (5): 659-662. Martin DR, ...
"Identification of two novel mutations in adenine phosphoribosyltransferase gene in patients with 2,8-dihydroxyadenine ... 2,8-Dihydroxyadenine is a derivative of adenine which accumulates in 2,8 dihydroxy-adenine urolithiasis. Diculescu, VC; Piedade ...
Examples include: adenine phosphoribosyltransferase hypoxanthine-guanine phosphoribosyltransferase pertussis toxin poly ADP ...
These enzymes found in the glycosome to help with synthesis are guanine and adenine phosphoribosyl transferase, hypoxanthine, ...
... adenine phosphoribosyltransferase EC 2.4.2.8: hypoxanthine phosphoribosyltransferase EC 2.4.2.9: uracil ... orotate phosphoribosyltransferase EC 2.4.2.11: now EC 6.3.4.21 EC 2.4.2.12: nicotinamide phosphoribosyltransferase EC 2.4.2.13 ... ATP phosphoribosyltransferase EC 2.4.2.18: anthranilate phosphoribosyltransferase EC 2.4.2.19: nicotinate-nucleotide ... nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase EC 2.4.2.22: xanthine phosphoribosyltransferase EC 2.4. ...
... adenine phosphoribosyltransferase MeSH D08.811.913.400.725.115 --- adp ribose transferases MeSH D08.811.913.400.725.115.180 ... anthranilate phosphoribosyltransferase MeSH D08.811.913.400.725.200 --- ATP phosphoribosyltransferase MeSH D08.811.913.400. ... 725.450 --- hypoxanthine phosphoribosyltransferase MeSH D08.811.913.400.725.700 --- orotate phosphoribosyltransferase MeSH ... flavin-adenine dinucleotide MeSH D08.211.474.650.500 --- flavin mononucleotide MeSH D08.211.790.249 --- g(m2) activator protein ...
... thumb club foot syndrome Adducted thumb syndrome recessive form Adducted thumbs Dundar type Adenine phosphoribosyltransferase ...
Adenine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase Orotate phosphoribosyltransferase Uracil ... A phosphoribosyltransferase is a type of transferase enzyme. Types include: ...
"Adenine phosphoribosyltransferase isoforms of Arabidopsis and their potential contributions to adenine and cytokinin metabolism ... Adenine phosphoribosyltransferase (APRTase) is an enzyme encoded by the APRT gene, found in humans on chromosome 16. It is part ... Adenine phosphoribosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) Human APRT genome ... Takeuchi H, Kaneko Y, Fujita J, Yoshida O (Apr 1993). "A case of a compound heterozygote for adenine phosphoribosyltransferase ...
Their relationship to hypoxanthine and adenine phosphoribosyltransfer activities". J. Biol. Chem. 245 (10): 2605-11. PMID ... In enzymology, a xanthine phosphoribosyltransferase (EC 2.4.2.22) is an enzyme that catalyzes the chemical reaction XMP + ... Other names in common use include Xan phosphoribosyltransferase, xanthosine 5'-phosphate pyrophosphorylase, xanthylate ...
Revollo JR, Grimm AA, Imai S (March 2007). "The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/ ... Nicotinamide phosphoribosyltransferase (NAmPRTase or Nampt) also known as pre-B-cell colony-enhancing factor 1 (PBEF1) or ... This protein is the rate-limiting enzyme in the Nicotinamide adenine dinucleotide (NAD+) salvage pathway that converts ... is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis". Eur. J. Immunol. 32 (11): 3225- ...
... at NIH's Office of Rare Diseases APRT at the Rare Kidney Stones Consortium. ... Adenine phosphoribosyltransferase deficiency (also called APRT deficiency or 2,8 dihydroxyadenine urolithiasis) is an autosomal ... Patients with the disease deficiency lack the enzyme adenine phosphoribosyltransferase and therefore have difficulties breaking ... Kamatani, N (December 1996). "Adenine phosphoribosyltransferase(APRT) deficiency" (Free full text). Nippon rinsho. Japanese ...
... which plays a role in nicotinamide adenine dinucleotide biosynthesis. P7C3 compounds have previously been shown in a number of ... drug compounds P7C3 analogues involved in enhancing the activity of the enzyme nicotinamide phosphoribosyltransferase, ...
... adenine) phosphoribosyltransferase, nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase, and nicotinate ... In enzymology, a nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) is an enzyme that ... Other names in common use include CobT, nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase, nicotinate ... 6-dimethylbenzimidazole phosphoribosyltransferase responsible for the synthesis of N1-(5-phospho-alpha-D-ribosyl)-5,6- ...
Adenine Guanine Xanthine "Estimation of Plasmodium falciparum drug susceptibility by the 3H-hypoxanthine uptake inhibition ... Hypoxanthine-guanine phosphoribosyltransferase converts hypoxanthine into IMP in nucleotide salvage. Hypoxanthine is also a ... Because of its resemblance to guanine, the spontaneous deamination of adenine can lead to an error in DNA transcription/ ... including the DNA and RNA components adenine and guanine, may have been formed extraterrestrially in outer space. The Pheretima ...
Phosphoribosyltransferase. *Adenine phosphoribosyltransferase. *Hypoxanthine-guanine phosphoribosyltransferase. *Uracil ...
Phosphoribosyltransferase. *Adenine phosphoribosyltransferase. *Hypoxanthine-guanine phosphoribosyltransferase. *Uracil ...
Hypoxanthine-guanine phosphoribosyltransferase. *Adenine phosphoribosyltransferase. Catabolism. *Adenosine deaminase. *Purine ... of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine ...
Phosphoribosyltransferase. *Adenine phosphoribosyltransferase. *Hypoxanthine-guanine phosphoribosyltransferase. *Uracil ...
Phosphoribosyltransferase. *Adenine phosphoribosyltransferase. *Hypoxanthine-guanine phosphoribosyltransferase. *Uracil ...
Adenine phosphoribosyltransferase deficiency. Catabolism. *Adenosine deaminase deficiency. *Purine nucleoside phosphorylase ... Purine content of foods varies (see Gout). Foods high in the purines adenine and hypoxanthine may be more potent in ... Ethanol also increases the plasma concentrations of hypoxanthine and xanthine via the acceleration of adenine nucleotide ... in serum and urinary uric acid levels in normal human subjects fed purine-rich foods containing different amounts of adenine ...
3. 25 mum-6-Mercaptopurine did not inhibit adenine phosphoribosyltransferase. 6-Mercaptopurine is a competitive inhibitor of ... 2. At pH 7.8 and 25 degrees the Michaelis constants for adenine, guanine and hypoxanthine were 0.9 mum, 2.9 mum and 11.0 mum in ... guanine phosphoribosyltransferase (K(i) 4.7 mum) and hypoxanthine phosphoribosyltransferase (K(i) 8.3 mum). Hypoxanthine is a ... adenine, [8-(14)C]guanine and [8-(14)C]hypoxanthine respectively in the presence of 5-phosphoribosyl pyrophosphate and an ...
Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase Magnus S. Alphey , Gemma Fisher , Ying Ge ... In both ternary complexes with PRPP-ATP, the adenine ring is found in an anticatalytic orientation, rotated 180° from the ... The enzyme ATP phosphoribosyltransferase (ATPPRT) catalyses the first reaction in histidine biosynthesis, the magnesium- ...
... medlineplus.gov/genetics/condition/adenine-phosphoribosyltransferase-deficiency/ Adenine phosphoribosyltransferase deficiency. ... Adenine phosphoribosyltransferase (APRT) deficiency is an inherited condition that affects the kidneys and urinary tract. The ... Adenine phosphoribosyltransferase deficiency in children. Pediatr Nephrol. 2012 Apr;27(4):571-9. doi: 10.1007/s00467-011-2037-0 ... Bollée G, Harambat J, Bensman A, Knebelmann B, Daudon M, Ceballos-Picot I. Adenine phosphoribosyltransferase deficiency. Clin J ...
"Adenine phosphoribosyltransferase isoforms of Arabidopsis and their potential contributions to adenine and cytokinin metabolism ... Adenine phosphoribosyltransferase (APRTase) is an enzyme encoded by the APRT gene, found in humans on chromosome 16. It is part ... Adenine phosphoribosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) Human APRT genome ... Takeuchi H, Kaneko Y, Fujita J, Yoshida O (Apr 1993). "A case of a compound heterozygote for adenine phosphoribosyltransferase ...
Adenine phosphoribosyltransferase deficiency at NIHs Office of Rare Diseases APRT at the Rare Kidney Stones Consortium. ... Adenine phosphoribosyltransferase deficiency (also called APRT deficiency or 2,8 dihydroxyadenine urolithiasis) is an autosomal ... Patients with the disease deficiency lack the enzyme adenine phosphoribosyltransferase and therefore have difficulties breaking ... Kamatani, N (December 1996). "Adenine phosphoribosyltransferase(APRT) deficiency" (Free full text). Nippon rinsho. Japanese ...
Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. S J Engle, M G Stockelman, J ... Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. S J Engle, M G Stockelman, J ... Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. S J Engle, M G Stockelman, J ... Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis Message Subject (Your Name) has ...
Adenine Phosphoribosyltransferase (APRT) Antigen-Profil Beschreibung des Gens Adenine phosphoribosyltransferase belongs to the ... Weitere Produktkategorien zu Adenine Phosphoribosyltransferase Antikörper * 93 anti-Adenine Phosphoribosyltransferase Primary ... anti-Adenine Phosphoribosyltransferase (APRT) Antikörper. Bezeichnung:. anti-Adenine Phosphoribosyltransferase Antikörper (APRT ... Am meisten referenzierte anti-Adenine Phosphoribosyltransferase Antikörper. Show all anti-Adenine Phosphoribosyltransferase ( ...
OMIM: ADENINE PHOSPHORIBOSYLTRANSFERASE; APRT, 614723*Gene Ontology: Aprt *Mouse Phenome DB: Aprt *UCSC: Chr.8:122,574,637- ... adenine phosphoribosyl transferase. Gene nomenclature, locus information, and GO, OMIM, and PMID associations are updated daily ...
CheckOrphan is a non-profit organization located in Basel, Switzerland and Santa Cruz, California that is dedicated to rare, orphan and neglected diseases. CheckOrphan offers users an interactive and dynamic platform for all these diseases. This strategy allows visitors to be updated daily on all the latest news and interact with people internationally. This is essential, because due to the nature of these diseases, there is not a large concentration of individuals within any given proximity ...
APRT adenine phosphoribosyltransferase [ Homo sapiens ]. Synonyms:. APRT; adenine phosphoribosyltransferase; AMP; MGC125856; ... AMP binding; adenine binding; adenine phosphoribosyltransferase activity; protein binding; transferase activity, transferring ... Recombinant Human Adenine phosphoribosyltransferase. Download Datasheet See All APRT Products. Bring this labeled protein ... APRT (adenine phosphoribosyltransferase) is a 180 amino acid protein that localizes to the cytoplasm and belongs to the purine/ ...
... which catalyzes the conversion of adenine to adenylic acid in the presence of phosphoribosylpyrophosphate (PRPP). In a complete ... Adenine phosphoribosyltransferase (APRT) is a purine salvage enzyme, ... Adenine phosphoribosyltransferase (APRT) is a purine salvage enzyme, which catalyzes the conversion of adenine to adenylic acid ... Y. Hidaka, S. A. Tarie, S. Fujimori, N. Kamatani, W. N. Kelley, and T. D. Palella, Human adenine phosphoribosyltransferase ...
Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend ... Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend ... Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend ... Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend ...
Recombinant Protein and Adenine phosphoribosyltransferase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and ... Adenine phosphoribosyltransferase. Adenine phosphoribosyltransferase ELISA Kit. Adenine phosphoribosyltransferase Recombinant. ... Adenine phosphoribosyltransferase 1. Adenine phosphoribosyltransferase 1 ELISA Kit. Adenine phosphoribosyltransferase 1 ... Adenine phosphoribosyltransferase 2. Adenine phosphoribosyltransferase 2 ELISA Kit. Adenine phosphoribosyltransferase 2 ...
Identification of a splice mutation at the adenine phosphoribosyltransferase locus in a German family. *Birgit S. Gathof, Amrik ... A complete cDNA for adenine phosphoribosyltransferase fromArabidopsis thaliana. *Barbara A. Moffatt, Elizabeth Mcwhinnie, ... The origin of the most common mutation of adenine phosphoribosyltransferase among Japanese goes back to a prehistoric era. * ... Intervention of somatic mutational events in vivo by a germline defect at the adenine phosphoribosyltransferase locus. * ...
Adenine Phosphoribosyltransferase (APRT) profil antigène Antigen Summary Adenine phosphoribosyltransferase belongs to the ... De plus, nous expédions Adenine Phosphoribosyltransferase Protéines (18) et Adenine Phosphoribosyltransferase Kits (11) et ... Alternative names and synonyms associated with Adenine Phosphoribosyltransferase (APRT) * adenine phosphoribosyltransferase ( ... anti-Adenine Phosphoribosyltransferase Anticorps (APRT). Chez www.anticorps-enligne.fr sont 101 Adenine ...
Adenine phosphoribosyltransferase deficiency. At least 40 mutations in the APRT gene have been found to cause adenine ... The APRT gene provides instructions for making an enzyme called adenine phosphoribosyltransferase (APRT). This enzyme is ... Bollée G, Harambat J, Bensman A, Knebelmann B, Daudon M, Ceballos-Picot I. Adenine phosphoribosyltransferase deficiency. Clin J ... APRT gene mutations lead to a lack of functional enzyme that prevents the conversion of adenine to AMP. As a result, adenine is ...
Total deficiency of adenine phosphoribosyltransferase was confirmed by direct measurements of the enzyme activity in lysed red ...
Adenine phosphoribosyltransferase - Also known as APT_BURP6, apt. Catalyzes a salvage reaction resulting in the formation of ...
Adenine phosphoribosyltransferase - Also known as APT_STRAW, apt. Catalyzes a salvage reaction resulting in the formation of ...
Adenine phosphoribosyltransferase - Also known as APT_HUMAN, APRT. Catalyzes a salvage reaction resulting in the formation of ...
... Title:. Adenine Phosphoribosyltransferase ... Adenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive disorder of adenine metabolism that results ...
It can act as a salvage enzyme for recycling of adenine into nucleic acids. EC 2.4.2.7. ... An enzyme catalyzing the formation of AMP from adenine and phosphoribosylpyrophosphate. ...
Variants studied for adenine phosphoribosyltransferase deficiency Included ClinVar conditions (1):*Adenine ...
Mutants deficient in adenine aminohydrolase (EC 3.5.4.2) activity, aahl, and hypoxanthine: guanine phosphoribosyltransferase ( ... and strains of the genotype ade2 aptl responded to both adenine and hypoxanthine. ... in strains with these genotypes confirmed the hypothesis that the residual A-PRT activity of aptl mutants was due to adenine ... aminohydrolase and hypoxanthine:guanine phosphoribosyltransferase acting in concert. ...
Emmerson, B.T., Gordon, R.B. and Thompson, L.: Adenine phosphoribosyltransf erase deficiency in a female with gout. Ibid 41 A: ... Partial deficiency of adenine phosphoribosyltransferase (APRT), the enzyme catalyzing the transport of the ribosylphosphate ... Delbarre, F., Auscher, C., Amor, B. and de Gery, A.: Gout with adenine phosphoribosyltransferase deficiency. Ibid. 41 A: 333, ... Van Acker K.J., Simmonds H.A., Cameron J.S. (1977) Complete Deficiency of Adenine Phosphoribosyltransferase: Report of a Family ...
EnzymeHuman AdenineDeficiency of adenine phosphoribosyltransferaseHypoxanthinePathwaysPRPPNucleotideNucleotidesCalled purinesConversion of adenineSalvageKamataniNucleosidePyrimidineNicotinamide PhosphoribosyltransferaseMetabolismPhosphoribosyl PyrophosphateEnzymesThermusDeaminaseUrinaryRenalProteinDeficientPathwayMice
- The enzyme ATP phosphoribosyltransferase (ATPPRT) catalyses the first reaction in histidine biosynthesis, the magnesium-dependent condensation of ATP and 5-phospho--D-ribosyl-1-pyrophosphate (PRPP) to generate N1-(5-phospho--D-ribosyl)-ATP (PRATP) and pyrophosphate (PPi). (diamond.ac.uk)
- Three-dimensional structure of human adenine phosphoribosyltransferase and its relation to DHA-urolithiasis. (medlineplus.gov)
- Total deficiency of adenine phosphoribosyltransferase was confirmed by direct measurements of the enzyme activity in lysed red blood cells. (lsh.is)
- Van Acker K.J., Simmonds H.A., Cameron J.S. (1977) Complete Deficiency of Adenine Phosphoribosyltransferase: Report of a Family. (fjmu.edu.cn)
- Two cases of 2.8-dihydroxyadenine stone with a partial deficiency of adenine phosphoribosyltransferase]. (lsh.is)
- The mutants appeared to retain some A-PRT activity in crude extracts, and strains of the genotype ade2 aptl responded to both adenine and hypoxanthine. (microbiologyresearch.org)
- Mutants deficient in adenine aminohydrolase (EC 3.5.4.2) activity, aahl , and hypoxanthine: guanine phosphoribosyltransferase (EC 2.4.2.8) activity, hptl , were used to synthesize the genotypes aptl hptl aah * and aptl hpt* aahl. (microbiologyresearch.org)
- The absence of A-PRT activity in strains with these genotypes confirmed the hypothesis that the residual A-PRT activity of aptl mutants was due to adenine aminohydrolase and hypoxanthine:guanine phosphoribosyltransferase acting in concert. (microbiologyresearch.org)
- Deficiencies of enzymes involved in the purine reutilization pathways mainly concern the hypoxanthine-guanine phosphoribosyltransferase (HGPRT), the clinical expression being the Lesch-Nyhan syndrome or eventually gout. (fjmu.edu.cn)
- Besides adenine and adenosine, hypoxanthine (Hyp) is usually considered a major substrate of salvage pathways. (springer.com)
- Hypoxanthine-guanine phosphoribosyltransferase (HPRT, EC 2.4.2.8) is a purine salvage enzyme that catalyses the conversion of hypoxanthine and guanine to their respective mononucleotides. (hmdb.ca)
- Group 1: The patient may have deficiencies in hypoxanthine-guanine phosphoribosyltransferase (HGPRT), adenine phosphoribosyltransferase, or xanthine dehydrogenase enzymes. (medscape.com)
- Wild-type cells incorporated labeled adenine, guanine, and hypoxanthine, whereas mutant strains varied in their ability to incorporate these bases. (asm.org)
- Adenine, guanine, hypoxanthine, and xanthine were activated by phosphoribosyltransferase activities present in wild-type cell extracts. (asm.org)
- When APRTase has reduced or nonexistent activity, adenine accumulates from other pathways. (wikipedia.org)
- There are two pathways whereby AMP is synthesized in erythrocytes: from adenine and adenosine. (springer.com)
- APRTase catalyzes the following reaction in the purine nucleotide salvage pathway: Adenine + Phosphoribosyl Pyrophosphate (PRPP) → Adenylate (AMP) + Pyrophosphate (PPi) In organisms that can synthesize purines de novo, the nucleotide salvage pathway provides an alternative that is energetically more efficient. (wikipedia.org)
- The enzyme first binds PRPP, followed by adenine. (wikipedia.org)
- This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). (antikoerper-online.de)
- Phosphoribosyltransferases add activated ribose-5-phosphate ( Phosphoribosyl pyrophosphate , PRPP) to bases, creating nucleoside monophosphates. (wikipedia.org)
- Both adenine and guanine are derived from the nucleotide inosine monophosphate (IMP), which is synthesised on a pre-existing ribose-phosphate through a complex pathway using atoms from the amino acids glycine, glutamine, and aspartic acid, as well as formate ions transferred from the coenzyme tetrahydrofolate . (wikibooks.org)
- Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. (drugbank.ca)
- Nucleotide sequence and deduced amino acid sequence of Escherichia coli adenine phosphoribosyltransferase and comparison with other analogous enzymes. (yale.edu)
- May contribute to the recycling of adenine into adenylate nucleotides and the inactivation of cytokinins by phosphoribosylation. (mybiosource.com)
- Possesses low activity toward adenine, but can efficiently convert cytokinins from free bases (active form) to the corresponding nucleotides (inactive form). (mybiosource.com)
- Adenine phosphoribosyltransferase is widely spread in nature, it is produced in bacteria and eukaryotes, participates in the alternative de novo synthesis of purine nucleotides. (creative-enzymes.com)
- a nucleoside found among the hydrolysis products of all nucleic acids and of the various adenine nucleotides. (goutpal.com)
- Patients with the disease deficiency lack the enzyme adenine phosphoribosyltransferase and therefore have difficulties breaking down dietary substances called purines, resulting in accumulation of a compound called 2,8-dihydroxyadenine (2,8-DHA) that is excreted by the kidneys. (wikipedia.org)
- A lack of functional enzyme impairs the conversion of adenine to AMP. (medlineplus.gov)
- It can salvage adenine from the polyamine biosynthetic pathway or from dietary sources of purines. (wikipedia.org)
- EC 2.4.2.7), which is a constitutively expressed enzyme involved in the one-step salvage of adenine to AMP. (mybiosource.com)
- Purine phosphoribosyltransferases, purine PRTs, are essential enzymes in the purine salvage pathway of living organisms. (universidadeuropea.es)
- The salvage of adenine depends upon two sequential enzymatic reactions. (springer.com)
- S. Fujimori, I. Akaoka, K. Sakamoto, H. Yamanaka, K. Nishioka and N. Kamatani, Common characteristics of mutant adenine phospho-ribosyltransferases from four separate Japanese families with 2, 8-dihydroxyadenine urolithiasis associated with partial enzyme deficiency, Hum. (springer.com)
- T. Nobori, N. Kamatani, K. Mikanagi, Y. Nishida, and K. Nishioka, Establishment and characterization of B cell lines from individuals with various types of adenine phosphoribosyltransferase deficiencies. (springer.com)
- A nucleoside that is composed of adenine and d-ribose. (drugbank.ca)
- A phosphorylated nucleoside C 10 H 16 N 5 O 13 P 3 of adenine that supplies energy for many biochemical cellular processes by undergoing enzymatic hydrolysis (especially to adenosine diphosphate). (goutpal.com)
- Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. (antikoerper-online.de)
- Nicotinamide phosphoribosyltransferase (NAMPT) is a regulator of the intracellular nicotinamide adenine dinucleotide (NAD) pool. (nature.com)
- Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. (nature.com)
- On the right, the biosynthesis of IMP is depicted in more detail (adapted from: https://en.wikipedia.org/wiki/Purine_metabolism). (wikipathways.org)
- Data indicates that the flexible loop structure adopts an open conformation before and after binding of both substrates adenine and phosphoribosyl pyrophosphate. (anticorps-enligne.fr)
- The hood, which contains the adenine binding site, has more variability within the family of enzymes. (wikipedia.org)
- Herein, we report a simple and thermostable process for the one-pot, one-step synthesis of some purine NMPs using xanthine phosphoribosyltransferase, XPRT or adenine phosphoribosyltransferase, APRT2, from Thermus thermophilus HB8. (universidadeuropea.es)
- Adenine deaminase activity was detected at low levels. (asm.org)
- Corrigendum to "Quantitative UPLC-MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiency" [J. Chromatogr. (lsh.is)
- Adenine phosphoribosyltransferase deficiency: a case diagnosed by GC-MS identification of 2,8-dihydroxyadenine in urinary crystals. (lsh.is)
- Emmerson, B.T., Gordon, R.B. and Thompson, L.: Adenine phosphoribosyltransf erase deficiency: its inheritance and occurrence in a female with gout and renal disease. (fjmu.edu.cn)
- Both adenine-fed wild-type (WT) and Jα18KO mice exhibited renal dysfunction, but adenine-fed Jα18KO mice presented higher expression of kidney injury molecule-1 (KIM-1), tumor necrosis factor (TNF)-α and type I collagen. (springer.com)
- However, this improvement in renal function was not observed in IFN-γKO mice after αGalCer treatment and adenine feeding, illustrating that this cytokine plays a role in our model. (springer.com)
- 6 ) demonstrated that an excessive intake of adenine would lead to renal injury. (springer.com)
- Adenine is produced endogenously but its long-term ingestion results in 2,8-dihydrox-yadenine precipitation inside the renal tubules, leading to the formation of kidney stones, with extensive tubular dilation, inflammation, necrosis and fibrosis. (springer.com)
- Zusätzlich bieten wir Ihnen Adenine Phosphoribosyltransferase Proteine (18) und Adenine Phosphoribosyltransferase Kits (11) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
- SUMMARY: Mutants of Saccharomyces cerevisiae deficient in adenine phosphoribosyltransferase (A-PRT, EC 2.4.2.7) have been isolated following selection for resistance to 8-azaadenine in a prototrophic strain carrying the ade4-su allele of the gene coding for amidophosphoribosyltransferase(EC 2.4.2.14). (microbiologyresearch.org)
- It also produces adenine as a by-product of the polyamine biosynthesis pathway. (creativebiomart.net)
- To analyze the role of activated iNKT cells in our model, we administered αGalCer in WT mice during adenine ingestion. (springer.com)