Adenine Phosphoribosyltransferase
Pentosyltransferases
Hypoxanthine Phosphoribosyltransferase
An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
Hypoxanthines
Phosphoribosyl Pyrophosphate
Orotate Phosphoribosyltransferase
Chromosomes, Human, 16-18
Nicotinamide Phosphoribosyltransferase
An enzyme that catalyzes the formation of nicotinamide mononucleotide (NMN) from nicotinamide and 5-phosphoribosyl-1-pyrophosphate, the rate-limiting step in the biosynthesis of the NAD coenzyme. It is also known as a growth factor for early B-LYMPHOCYTES, or an ADIPOKINE with insulin-mimetic effects (visfatin).
Azaserine
Purines
Lesch-Nyhan Syndrome
An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
ATP Phosphoribosyltransferase
Purine-Nucleoside Phosphorylase
Carcinoma, Ehrlich Tumor
Adenosine Monophosphate
Anthranilate Phosphoribosyltransferase
Cricetinae
Nucleotides
Mutation
Hybrid Cells
Genes
Base Sequence
Azaguanine
Cricetulus
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Blotting, Southern
Glucosyltransferases
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
CHO Cells
Erythrocytes
Alleles
Acrylamides
Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.
Nicotinamide Mononucleotide
Amino Acid Sequence
Developmental changes in purine phosphoribosyltransferases in human and rat tissues. (1/221)
1. The hypoxanthine/guanine and adenine phosphoribosyltransferase activities in a wide variety of human tissues were studied during their growth and development from foetal life onward. A wide range of activities develop after birth, with especially high values in the central nervous system and testes. 2. Postnatal development of hypoxanthine/guanine phosphoribosyltransferase was also defined in the rat. Although there were increases in the central nervous system and testes, there was also a rise in activity in the liver, which was less marked in man. 3. A sensitive radiochemical assay method, using dTTP to inhibit 5'-nucleotidase activity, suitable for tissue extracts, was developed. 4. No definite evidence of the existence of tissue-specific isoenzymes of hypoxanthine/guanine or adenine phosphoribosyltransferase was found. Hypoxanthine/guanine phosphoribosyltransferase in testes, however, had a significantly different thermal-denaturation rate constant. 5. The findings are discussed in an attempt to relate activity of hypoxanthine/guanine phosphoribosyltransferase to biological function. Growth as well as some developmental changes appear to be related to increase in the activity of this enzyme. (+info)A novel signature mutation for oxidative damage resembles a mutational pattern found commonly in human cancers. (2/221)
To determine the types of mutations induced by oxidative damage, a kidney cell line with a heterozygous deficiency for the autosomal Aprt (adenine phosphoribosyltransferase) gene was tested for its mutagenic response to hydrogen peroxide. Aprt-deficient cells were selected and scored for loss of heterozygosity (LOH) for 11 microsatellite loci on mouse chromosome 8. On the basis of the LOH analysis, spontaneous mutants (n = 38) were distributed into four classes: apparent point mutation, mitotic recombination, chromosome loss, and large interstitial deletion. However, 9 of 20 (45%) hydrogen peroxide-induced mutants exhibited a novel class of mutations characterized by "discontinuous LOH" for one or more of the microsatellite loci. Interestingly, mutations resembling discontinuous LOH are commonly observed in a wide variety of human cancers. Our data suggest that discontinuous LOH is a signature mutational pattern for oxidative damage and further suggest that such genetic damage is widespread in cancer. (+info)Effect of interferon-gamma on purine catabolic and salvage enzyme activities in rats. (3/221)
To determine whether interferon-gamma affects rat purine catabolic and salvage enzyme activities, rats were injected with interferon-gamma (600000 U/kg, i.p.) and, similarly to a vehicle-injected control group, killed before or after injection at 6, 12, and 24 h. Organ homogenates were prepared and enzymatic reactions with substrates were carried out, after which the products were measured either chromatographically or spectrophotometrically. Western and Northern blotting also were performed. In contrast to the vehicle-injected rats, interferon-gamma-injected rats showed a significant rise in xanthine oxidoreductase activity in the liver, while enzyme activity was unchanged in the spleen, kidney, and lung. Western analysis of hepatic xanthine oxidoreductase showed an increased concentration of this protein 12 and 24 h after interferon-gamma injection. Northern analysis disclosed an enhanced mRNA expression coding for this enzyme, peaking 12 h after injection. Contrastingly, the activities of adenosine deaminase, purine nucleoside phosphorylase, hypoxanthine guanine phosphoribosyltransferase, and adenine phosphoribosyltransferase were not affected by interferon-gamma in any organ tested. While interferon-gamma causes an increased hepatic biosynthesis of xanthine oxidoreductase, the physiologic role of this enzyme induction remains undetermined. (+info)Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani. (4/221)
The enzyme adenine phosphoribosyltransferase (APRT) functions to salvage adenine by converting it to adenosine-5-monophosphate (AMP). APRT deficiency in humans is a well characterized inborn error of metabolism, and APRT may contribute to the indispensable nutritional role of purine salvage in protozoan parasites, all of which lack de novo purine biosynthesis. We determined crystal structures for APRT from Leishmania donovani in complex with the substrate adenine, the product AMP, and sulfate and citrate ions that appear to mimic the binding of phosphate moieties. Overall, these structures are very similar to each other, although the adenine and AMP complexes show different patterns of hydrogen-bonding to the base, and the active site pocket opens slightly to accommodate the larger AMP ligand. Whereas AMP adopts a single conformation, adenine binds in two mutually exclusive orientations: one orientation providing adenine-specific hydrogen bonds and the other apparently positioning adenine for the enzymatic reaction. The core of APRT is similar to that of other phosphoribosyltransferases, although the adenine-binding domain is quite different. A C-terminal extension, unique to Leishmania APRTs, extends an extensive dimer interface by wrapping around the partner molecule. The active site involves residues from both subunits of the dimer, indicating that dimerization is essential for catalysis. (+info)Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice. (5/221)
Mice heterozygous at Aprt (adenine phosphoribosyltransferase) were used as a model to study in vivo loss of heterozygosity (LOH) in normal fibroblasts. Somatic cell variants that exhibited functional loss of the wild-type Aprt in vivo were recovered as APRT-deficient cell colonies after culturing in selection medium containing 2, 6-diaminopurine (DAP), an adenine analog that is toxic only to cells with APRT enzyme activity. DAP-resistant (DAP(r)) fibroblast variants were recovered at a median frequency of 12 x 10(-5) from individual ears from progeny of crosses between mouse strains 129/Sv and C3H/HeJ. The frequency of DAP(r) variants varied greatly among individual ears, suggesting that they preexisted in vivo and arose at various times during development. Polymorphic molecular markers and a cytological marker on the centromere of chromosome 8 made it possible to discriminate between each of six possible mechanistic pathways of LOH. The majority (about 80%) of the DAP(r) variants were a consequence of mitotic recombination. The prevalence of mitotic recombination in regions proximal to Aprt did not correlate with meiotic map distances. In particular, there was a higher than expected frequency of crossovers within the interval 59 cM to 67 cM. The high spontaneous frequency of Aprt LOH, mediated primarily by mitotic recombination, is fully consistent with our previous results with human peripheral T cells from individuals known to be heterozygous at APRT. Thus, this Aprt heterozygote mouse is a valid model for studying somatic mutagenesis and mitotic recombination in vivo. (+info)Enhanced amsacrine-induced mutagenesis in plateau-phase Chinese hamster ovary cells, with targeting of +1 frameshifts to free 3' ends of topoisomerase II cleavable complexes. (6/221)
Previous work showed that the DNA double-strand cleaving agents bleomycin and neocarzinostatin were more mutagenic in plateau-phase than in log-phase cells. To determine whether topoisomerase II poisons that produce double-strand breaks by trapping of cleavable complexes would, likewise, induce mutations specific to plateau-phase cells, aprt mutations induced by amsacrine in both log-phase and plateau-phase CHO cells were analyzed. The maximum aprt mutant frequencies obtained were 7 x 10(-6) after treatment with 0.02 microM amsacrine in log phase and 27 x 10(-6) after treatment with 1 microM amsacrine in plateau phase, compared with a spontaneous frequency of < 1 x 10(-6). Base substitutions dominated the spectrum of mutations in log-phase cells, but were much less prevalent in plateau-phase cells. Both spectra also included small deletions, insertions and duplications, as well as few large-scale deletions or rearrangements. About 5% of the log-phase mutants and 16% of the plateau-phase mutants were +1 frameshifts, and all but one of these were targeted to potential free 3' termini of cleavable complexes, as determined by mapping of cleavage sites in DNA treated with topoisomerase II plus amsacrine in vitro. Thus, these insertions may arise from templated extension of the exposed 3' terminus by a DNA polymerase, followed by resealing of the strand, as shown previously for acridine-induced frameshifts in T4 phage. (+info)Solid tissues removed from ATM homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations. (7/221)
The presence of increased frequencies of blood-derived and solid tumors in ataxia-telangiectasia (A-T) patients, coupled with a role for the ATM (A-T mutation) protein in detecting specific forms of DNA damage, has led to the assumption of a mutator phenotype in A TM-deficient cells. Supporting this assumption are observations of increased rates of chromosomal aberrations and intrachromosomal homologous recombinational events in the cells of A-T patients. We have bred mice with knockout mutations for the selectable Aprt (adenine phosphoribosyltransferase) locus and the Atm locus to examine the frequency of second-step autosomal mutations in Atm-deficient cells. Two solid tissues were examined: (a) the ear, which yields predominately mesenchymal cells; and (b) the kidney, which yields predominately epithelial cells. We report here the lack of a mutator phenotype for inactivating autosomal mutations in solid tissues of the Atm-deficient mice. (+info)Localized Derepression on the Human Inactive X Chromosone in Mouse-Human Cell Hybrids. (8/221)
Evidence for derepression of the gene for hypoxanthine phosphoribosyltransferase (HPRT; IMP: pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) on the human inactive X chromosome was obtained in hybrids of mouse and human cells. The mouse cells lacked HPRT and were also deficient in adenine phosphoribosyltransferase (APRT; AMP: pyrophosphate phosphoribosyltransferase; EC2.4.2.7). The human female fibroblasts were HPRT-deficient as a consequence of a mutation on the active X but contained a normal HPRT gene on the inactive X. The two human X chromosomes were further distinguished by differences in morphology: the inactive X was morphologically normal while the active X included most of the long arm of autosome no. 1 translocated to the distal end of the X long arm. Forty-one hybrid clones were first isolated by selection for the presence of APRT; when these clones were selected for HPRT, six of them yielded derivatives having human HPRT with incidences of about 1 in 10-6 APRT-selected hybrid cells. The HPRT-positive derivatives contained a normal-appearing X chromosome indistinguishable from the inactive X of the parental human fibroblasts. The active X with the translocation was not found in any of the HPRT-positive hybrid cells. Human phosphoglycerokinase (ATP:3-phospho-D-glycerate 1-phosphotransferase. EC 2.7.2.3) and glucose-6-phosphate dehydrogenase (D-glucose 6-phosphate: NADP 1-oxidoreductase, EC 1.1.1.49), which are specified by X-chromosomal loci, were not detected in the hybrids expressing HPRT even though they contained an apparently intact X chromosome. The observations are most simply explained by the infrequent, stable derepression of inactive X chromosome segments that include the HPRT locus but not the phosphoglycerokinase and glucose-6-phosphate dehydrogenase loci. (+info)
Adenine Phosphoribosyltransferase Deficiency Symptoms, Doctors, Treatments, Advances & More | MediFind
Model involving gene inactivation in the generation of autosomal recessive mutants in mammalian cells in culture - UC Davis
UniProtKB/SwissProt variant VAR 069051
2,8- Dihydroxyadenine Urinary Stones | College of Veterinary Medicine - University of Minnesota
Plus it
SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA - Patent application
OriGene - APRT (NM 000485) Human ORF cDNA Clone
Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend...
Cloning, expression and biochemical characterization of xanthine and adenine phosphoribosyltransferases from thermus...
RT² qPCR Primer Assay for Mouse Aprt
Plus it
All transcript variants in gene APRT - Whole genome datasets
Human hg38 chr20:49,493,874-49,578,170 UCSC Genome Browser v395
Origin and Evolution of Eukaryotes
Studies on the mechanism of 3-deazaguanine cytotoxicity in L1210-sensitive and -resistant cell lines<...
Search Results | SOAR (Scholarly Open Access at Rutgers)
2,8 DHA Crystalline Nephropathy - Arkana Laboratories
Plus it
Hereditary causes of kidney stones and chronic kidney disease | SpringerLink
Most recent papers with the keyword gigley | Read by QxMD
APRT 153B: CONTROL SYSTEMS & CUSTOMER SERVICE II (TAB-4) | Foothill College
SAOUHSC 00766 - AureoWiki
NWMN RS06270 - AureoWiki
Ebook Investitionen, Unsicherheit Und Realoptionen
Allopurinol Tablets BP 100mg
The genetics of the Dras3-Roughened-ecdysoneless chromosomal region (62B3-4 to 62D3-4) in Drosophila melanogaster: analysis of...
Pages that link to Hypoxanthine-guanine phosphoribosyltransferase - wikidoc
A mycobacterial phosphoribosyltransferase promotes bacillary survival by inhibiting oxidative stress and autophagy pathways in...
Imprinting of phosphoribosyltransferases during preimplantation development of the mouse mutant, Hprtb-m3 | Development
Free Mecánica Estadística
Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency as the Unsuspected Cause of Renal Disease Spanning Three...
Disease InfoSearch - Partial hypoxanthine-guanine phosphoribosyltransferase deficiency - Definition, causes, resources and...
Rare Kidney Stone Consortium Biobank - Full Text View - ClinicalTrials.gov
X-chromosome activity in preimplantation mouse embryos from XX and XO mothers
Edema & Jaundice & Sloping Shoulders: Causes & Reasons - Symptoma
TIGR01091
Reactome | APRT [secretory granule lumen]
Arkansas Natural Gas Summary
Molecular and biochemical studies on the hypoxanthine-guanine phosphoribosyltransferases of the pathogenic haemoflagellates<...
RCSB PDB - Obsolete - 5HHU: Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9...
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain superfamily
RCSB PDB - 2GEB: Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I...
Effect of regional DNA methylation on gene expression. - MySci...
QPRT (quinolinate phosphoribosyltransferase) - KOMP (Knockout Mouse Project)
What does HGPRT stand for?
Lesch-Nyhan syndrome | DermNet NZ
Lesch-Nyhan Syndrome
HPRT1 Gene - GeneCards | HPRT Protein | HPRT Antibody
HPRT1 Gene - GeneCards | HPRT Protein | HPRT Antibody
Biochemical Correlates of Auto-Aggressive Behavior | SpringerLink
NIOSHTIC-2 Publications Search - 00111764 - Effect of acrylamide intoxication on pyridine nucleotide concentrations and...
Adenine phosphoribosyltransferase
"Adenine phosphoribosyltransferase isoforms of Arabidopsis and their potential contributions to adenine and cytokinin metabolism ... Adenine phosphoribosyltransferase (APRTase) is an enzyme encoded by the APRT gene, found in humans on chromosome 16. It is part ... Adenine+phosphoribosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) Human APRT genome ... Takeuchi H, Kaneko Y, Fujita J, Yoshida O (Apr 1993). "A case of a compound heterozygote for adenine phosphoribosyltransferase ...
Adenine phosphoribosyltransferase deficiency
... is an autosomal recessive metabolic disorder associated with a mutation in the ... Adenine phosphoribosyltransferase deficiency at NIH's Office of Rare Diseases (Articles with short description, Short ... Patients with the disease deficiency lack the enzyme adenine phosphoribosyltransferase and therefore have difficulties breaking ... "Adenine phosphoribosyltransferase(APRT) deficiency" (Free full text). Nippon Rinsho. Japanese Journal of Clinical Medicine. 54 ...
Allopurinol
... adenine phosphoribosyltransferase. It is also used to treat kidney stones caused by deficient activity of adenine ... hypoxanthine-guanine phosphoribosyltransferase, including Lesch-Nyhan syndrome; glucose 6-phosphatase including glycogen ... phosphoribosyltransferase. Allopurinol was also commonly used to treat tumor lysis syndrome in chemotherapeutic treatments, as ...
Kidney stone disease
People affected by adenine phosphoribosyltransferase deficiency may produce 2,8-dihydroxyadenine stones, alkaptonurics produce ... Kamatani N (December 1996). "[Adenine phosphoribosyltransferase(APRT) deficiency]". Nihon Rinsho. Japanese Journal of Clinical ...
Purine metabolism
The enzyme adenine phosphoribosyltransferase (APRT) salvages adenine. The enzyme hypoxanthine-guanine phosphoribosyltransferase ... Both adenine and guanine are derived from the nucleotide inosine monophosphate (IMP), which is the first compound in the ... Hyperuricemia and Lesch-Nyhan syndrome by the loss of hypoxanthine-guanine phosphoribosyltransferase. Different types of cancer ...
Nucleic acid metabolism
For example, adenine + PRPP --> AMP + PPi. This reaction requires the enzyme adenine phosphoribosyltransferase. Free guanine is ... Adenine and guanine are the two nucleotides classified as purines. In purine synthesis, PRPP is turned into inosine ... Lesch-Nyhan syndrome is caused by a deficiency in hypoxanthine-guanine phosphoribosyltransferase or HGPRT, the enzyme that ... salvaged in the same way except it requires hypoxanthine-guanine phosphoribosyltransferase. Defects in purine catabolism can ...
2-Fluoroadenine
Schaff, Dennis A. (1994). "The adenine phosphoribosyltransferase (APRT) selectable marker system". Plant Science. Elsevier BV. ... adenine phosphoribosyltransferase) genes. Therefore, knockouts or mutants for APT, which are resistant to 2-FA, can be selected ... "Mutants of Saccharomyces cerevisiae deficient in adenine phosphoribosyltransferase". Mutation Research/Fundamental and ... 2-Fluoroadenine (2-FA) is a toxic adenine antimetabolite which can be used in laboratory biological research for ...
Richard Axel
"DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells". Proceedings of the National Academy ...
Anton Yuryev
A Saccharomyces cerevisiae gene encoding a potential adenine phosphoribosyltransferase Yuryev A, and Corden JL. Yeast 1994;10 ( ...
Phosphoribosyl pyrophosphate
"Structural Complexes of Human Adenine Phosphoribosyltransferase Reveal Novel Features of the APRT Catalytic Mechanism". Journal ... Decreased levels of hypoxanthine guanine phosphoribosyl transferase (HGPRT) causes this accumulation, as PRPP is a substrate ... Salmonella typhimurium nicotinate phosphoribosyltransferase". Journal of Biological Chemistry. 268 (34): 26004-26010. doi: ... with the first step being N-alkylation of anthranilic acid catalysed by the enzyme anthranilate phosphoribosyltransferase. ...
Nucleotide salvage
There are two types of phosphoribosyltransferases: adenine phosphoribosyltransferase (APRT) and hypoxanthine-guanine ... Phosphoribosyltransferases add activated ribose-5-phosphate (Phosphoribosyl pyrophosphate, PRPP) to bases, creating nucleoside ... Hypoxanthine is acted upon by HGXPRT(hypoxanthine guanine xanthine phosphoribosyl transferase) in the parasite to convert the ... Nicotinate salvage is the process of regenerating nicotinamide adenine dinucleotide from nicotinic acid. This pathway is ...
2,8-Dihydroxyadenine
... is excreted in the urine because of a deficiency in the adenine salvage enzyme adenine phosphoribosyltransferase. The defect is ... 2,8-Dihydroxyadenine is a derivative of adenine which accumulates in 2,8 dihydroxy-adenine urolithiasis. The poorly soluble ... "Identification of two novel mutations in adenine phosphoribosyltransferase gene in patients with 2,8-dihydroxyadenine ...
2,6-Diaminopurine
Cancer cells are known to become resistant to DAP by losing their adenine phosphoribosyltransferase (APRT) function, a process ... 6-diaminopurine and 6-methylpurine that affect adenine phosphoribosyltransferase in Escherichia coli K-12]". Genetika. 13 (10 ... As the Z base, it is found instead of adenine (A) in the genetic material of some bacteriophage viruses. In August 2011, a ... 2-aminoadenine is an adenine substituting for a base in S-2L cyanophage DNA. Nature. 1977 Nov 24;270(5635):369-70. Jacinta ...
Pentosyltransferase
Examples include: adenine phosphoribosyltransferase hypoxanthine-guanine phosphoribosyltransferase pertussis toxin poly ADP ...
Glycosome
These enzymes found in the glycosome to help with synthesis are guanine and adenine phosphoribosyl transferase, hypoxanthine, ...
Phosphoribosyltransferase
Adenine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase Orotate phosphoribosyltransferase Quinolinate ... A phosphoribosyltransferase is a type of transferase enzyme. Types include: ... phosphoribosyltransferase Uracil phosphoribosyltransferase v t e (Transferases, All stub articles, Enzyme stubs). ...
Transphosphoribosidase
... may refer to: Adenine phosphoribosyltransferase, an enzyme Hypoxanthine phosphoribosyltransferase This ...
APRT
... may refer to: Adenine phosphoribosyltransferase, an enzyme Adenine phosphoribosyltransferase deficiency, a genetic and ...
Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase
... adenine) phosphoribosyltransferase, nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase, and nicotinate ... In enzymology, a nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) is an enzyme that ... Other names in common use include CobT, nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase, nicotinate ... 6-dimethylbenzimidazole phosphoribosyltransferase responsible for the synthesis of N1-(5-phospho-alpha-D-ribosyl)-5,6- ...
List of EC numbers (EC 2)
... adenine phosphoribosyltransferase EC 2.4.2.8: hypoxanthine phosphoribosyltransferase EC 2.4.2.9: uracil ... orotate phosphoribosyltransferase EC 2.4.2.11: now EC 6.3.4.21 nicotinate phosphoribosyltransferase EC 2.4.2.12: nicotinamide ... ATP phosphoribosyltransferase EC 2.4.2.18: anthranilate phosphoribosyltransferase EC 2.4.2.19: nicotinate-nucleotide ... nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase EC 2.4.2.22: xanthine phosphoribosyltransferase EC 2.4. ...
List of MeSH codes (D08)
... adenine phosphoribosyltransferase MeSH D08.811.913.400.725.115 - adp ribose transferases MeSH D08.811.913.400.725.115.180 - ... anthranilate phosphoribosyltransferase MeSH D08.811.913.400.725.200 - ATP phosphoribosyltransferase MeSH D08.811.913.400. ... 725.450 - hypoxanthine phosphoribosyltransferase MeSH D08.811.913.400.725.700 - orotate phosphoribosyltransferase MeSH D08.811. ... flavin-adenine dinucleotide MeSH D08.211.474.650.500 - flavin mononucleotide MeSH D08.211.790.249 - g(m2) activator protein ...
List of diseases (A)
... thumb club foot syndrome Adducted thumb syndrome recessive form Adducted thumbs Dundar type Adenine phosphoribosyltransferase ...
Xanthine phosphoribosyltransferase
Their relationship to hypoxanthine and adenine phosphoribosyltransfer activities". J. Biol. Chem. 245 (10): 2605-11. PMID ... In enzymology, a xanthine phosphoribosyltransferase (EC 2.4.2.22) is an enzyme that catalyzes the chemical reaction XMP + ... Other names in common use include Xan phosphoribosyltransferase, xanthosine 5'-phosphate pyrophosphorylase, xanthylate ...
Metaproteomics
... adenine phosphoribosyltransferases, and guanine phosphoribosyltransferases. The human subjects experienced increases in ...
Nicotinamide phosphoribosyltransferase
The intracellular form of this protein (iNAMPT) is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD+) ... Nicotinamide phosphoribosyltransferase (NAmPRTase or NAMPT), formerly known as pre-B-cell colony-enhancing factor 1 (PBEF1) or ... Revollo JR, Grimm AA, Imai S (March 2007). "The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/ ... Grolla AA, Travelli C, Genazzani AA, Sethi JK (July 2016). "Extracellular nicotinamide phosphoribosyltransferase, a new cancer ...
Nicotinamide adenine dinucleotide
The first step, and the rate-limiting enzyme in the salvage pathway is nicotinamide phosphoribosyltransferase (NAMPT), which ... Nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism. Found in all living cells, NAD is called a ... Nicotinamide adenine dinucleotide has several essential roles in metabolism. It acts as a coenzyme in redox reactions, as a ... "Nicotinamide-Adenine-Dinucleotide". pubchem.ncbi.nlm.nih.gov. The nicotinamide group can be attached in two orientations to the ...
Hypoxanthine
... also known as alkyl adenine glycosylase (Aag). Adenine Guanine Xanthine "Estimation of Plasmodium falciparum drug ... Hypoxanthine-guanine phosphoribosyltransferase converts hypoxanthine into IMP in nucleotide salvage. Hypoxanthine is also a ... Because of its resemblance to guanine, the spontaneous deamination of adenine can lead to an error in DNA transcription/ ... including the DNA and RNA components adenine and guanine, may have been formed extraterrestrially in outer space. The Pheretima ...
Joseph Takahashi
In 2009, Joseph Bass in collaboration with Takahashi's group discovered that nicotinamide phosphoribosyltransferase (NAMPT) ... mediated synthesis of metabolic coenzyme nicotinamide adenine dinucleotide (NAD+), which both oscillate on a daily cycle, may ...
MIR34A
miR-34a suppresses the gene expression of the NAMPT gene which encodes the nicotinamide phosphoribosyltransferase (Nampt) ... enzyme which is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD) salvage pathway, resulting in reduced ...
P7C3
The mechanism of action of the P7C3 series of compounds involves activation of nicotinamide phosphoribosyltransferase (NAMPT), ... the rate-limiting enzyme responsible for the transformation of nicotinamide into nicotinamide adenine dinucleotide (NAD). By ...
Nucleotide
The purine bases adenine and guanine and pyrimidine base cytosine occur in both DNA and RNA, while the pyrimidine bases thymine ... Orotate phosphoribosyltransferase (PRPP transferase) catalyzes the net reaction yielding orotidine monophosphate (OMP): Orotate ... Adenine forms a base pair with thymine with two hydrogen bonds, while guanine pairs with cytosine with three hydrogen bonds. In ... The four nucleobases in DNA are guanine, adenine, cytosine and thymine; in RNA, uracil is used in place of thymine. Nucleotides ...
Uracil
The others are adenine (A), cytosine (C), and guanine (G). In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the ... Uracil also recycles itself to form nucleotides by undergoing a series of phosphoribosyltransferase reactions. Degradation of ... Uracil pairs with adenine through hydrogen bonding. When base pairing with adenine, uracil acts as both a hydrogen bond ... In RNA, uracil base-pairs with adenine and replaces thymine during DNA transcription. Methylation of uracil produces thymine. ...
Lesch-Nyhan syndrome
The purine bases (adenine and guanine) and pyrimidine bases (thymine and cytosine) are bound to deoxyribose and phosphate and ... In Lesch-Nyhan syndrome, the defective gene is that for hypoxanthine-guanine phosphoribosyltransferase (HGPRT), a participant ... so named because it codes for the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT or HGPRT, EC 2.4.2.8). This ... is a rare inherited disorder caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT). This ...
Purine riboswitch
The add adenine riboswitch has shown three distinct stable conformations in the presence of adenine. When unbound to adenine, ... The xpt gene encodes a specific xanthine phosphoribosyltransferase protein, which is involved in purine metabolism. Unlike the ... The Adenine Riboswitch selectively recognizes adenine, and contains a uracil ribonucleotide in position 74 of the adenine- ... In this way, an abundance of adenine can instigate the process of adenine's efflux from a cell. Unlike the add adenine ...
Adenine phosphoribosyltransferase deficiency: MedlinePlus Genetics
Adenine phosphoribosyltransferase (APRT) deficiency is an inherited condition that affects the kidneys and urinary tract. ... medlineplus.gov/genetics/condition/adenine-phosphoribosyltransferase-deficiency/ Adenine phosphoribosyltransferase deficiency. ... Adenine phosphoribosyltransferase (APRT) deficiency is an inherited condition that affects the kidneys and urinary tract. The ... Adenine phosphoribosyltransferase deficiency in children. Pediatr Nephrol. 2012 Apr;27(4):571-9. doi: 10.1007/s00467-011-2037-0 ...
Human Adenine Phosphoribosyltransferase (APRT) Protein (Myc-DYKDDDDK Tag), Recombinant | ABIN2714849
Recombinant Adenine Phosphoribosyltransferase (APRT) Protein (Myc-DYKDDDDK Tag). Spezies: Human. Quelle: HEK-293 Cells. Jetzt ... Tb07.43M14.200, Tb07.43M14.180, C85684, AMP, APRTD, adenine phosphoribosyltransferase, adenine phosphoribosyl transferase, ... Adenine Phosphoribosyltransferase (APRT) (AA 2-180) protein (His tag) APRT Spezies: Ratte Wirt: Hefe Recombinant > 90 % ELISA ... Adenine Phosphoribosyltransferase (APRT) (AA 2-180) protein (His tag) APRT Spezies: Rind (Kuh) Wirt: Hefe Recombinant > 90 % ...
Mutations affecting adenine phosphoribosyl transferase activity in Chinese hamster cells. - Wikidata
Search Ageing-Associated Genes in Model Organisms
Adenine PhosphoribosylTransferase. Saccharomyces cerevisiae. Anti-Longevity APT1. 855660. AQR1. Aqr1p. Saccharomyces cerevisiae ... ADEnine requiring. Saccharomyces cerevisiae. Anti-Longevity ADE4. 852617. ADE5,7. ADEnine requiring. Saccharomyces cerevisiae. ... ADEnine requiring. Saccharomyces cerevisiae. Anti-Longevity ADE1. 855501. ADE12. ADEnine requiring. Saccharomyces cerevisiae. ... ADEnine requiring. Saccharomyces cerevisiae. Anti-Longevity ADE2. 853118. ADE3. ADEnine requiring. Saccharomyces cerevisiae. ...
Sol Genomics Network
Prospective Research Rare Kidney Stones - Mayo Clinic
Diseases Browser
ADENINE PHOSPHORIBOSYLTRANSFERASE; APRT 2,[email protected] UROLITHIASIS, INCLUDED. 102600. 11. ADENOCARCINOMA OF THE ...
Human Metabolome Database: Showing metabocard for Potassium (HMDB0000586)
US Patent for Alteration of Fc-fusion protein serum half-lives by mutagenesis Patent (Patent # 7,217,798 issued May 15, 2007) ...
USA 48:2026 (1962)), and adenine phosphoribosyltransferase (Lowy et al., Cell 22:817 (1980)) genes can be employed in tk-, ... The TNF-RII/Fc-fusion gene is followed by a gene encoding xanthine guanine phosphoribosyl transferase (gpt), together with ... hypoxanthine-guanine phosphoribosyltransferase (Szybalska & Szybalski, Proc. Natl. Acad. Sci. ...
Integration of transcriptomic and proteomic analyses reveals several levels of metabolic regulation in the excess starch and...
In this study, APRT (adenine phosphoribosyltransferase form 2) in lses1 showed a higher protein abundance level than that in WT ... Cloning a second form of adenine phosphoribosyl transferase gene (TaAPT2) from wheat and analysis of its association with ... and adenine phosphoribosyltransferase form 2 (APRT) involved in nucleic acid metabolism were regulated at both mRNA and protein ... adenine phosphoribosyltransferase form 2; KPR6: cyclin-dependent kinase inhibitor 6; TET6: tetraspanin-6; ASR5: abscisic stress ...
HOMD :: SEQF1139
HOMD :: SEQF2779
adenine phosphoribosyltransferase. 12. SEQF2779,CP000925.1. ABY79240.1 jb [NA] [AA] 375/124. 236421-236795. ribosomal protein ... adenine-specific DNA modification methylase. 147. SEQF2779,CP000925.1. ABY79375.1 jb [NA] [AA] 771/256. 306995-307765. ... nicotinate phosphoribosyltransferase (NAPRTase) family. 89. SEQF2779,CP000925.1. ABY79317.1 jb [NA] [AA] 1287/428. 303015- ...
Catalog Navigator : Microbiology and Molecular Genetics 681
METHODS OF REDUCING LACTATE IN LIVER DISEASE PATIENTS USING VARIANTS AND FUSIONS OF FGF19/FGF21 POLYPEPTIDES - NGM...
CoP: Co-expressed Biological Processes
American Society of Nephrology | Kidney Week - Abstract Details (2022)
nephrotic syndrome type 19 - Ontology Browser - Rat Genome Database
DeCS
Adenine Phosphoribosyltransferase Entry term(s). AMP Pyrophosphorylase APRTase Phosphoribosyltransferase, Adenine ... Adenine phosphoribosyltransferase Entry term(s):. AMP Pyrophosphorylase. APRTase. Phosphoribosyltransferase, Adenine. ... Adenine Phosphoribosyltransferase - Preferred Concept UI. M0000353. Scope note. An enzyme catalyzing the formation of AMP from ... An enzyme catalyzing the formation of AMP from adenine and phosphoribosylpyrophosphate. It can act as a salvage enzyme for ...
Code System Concept
Steven C. Almo - Publications
- Albert Einstein College of Medicine
OBM Geriatrics | Perspectives to Modify and Counter Aging in the Frame of Subtelomere-Telomere Theory of Aging
Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome | Orphanet Journal of Rare Diseases |...
Deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity is an inborn error of purine metabolism associated ... with increased adenine phosphoribosyltransferase (APRT) activity. Lesch-Nyhan patients (grade 4) present undetectable HPRT ... Phosphoribosyltransferase (PRT) deficiency in X-linked cerebral palsy and in a variant of gout. J Pediatr. 1968, 73: 583-592. ... Puig JG, Torres RJ, Mateos FA, Ramos T, Buno AS, Arcas J: The spectrum of hypoxanthine-guanine phosphoribosyltransferase (HPRT ...
Coffea arabica L. - ICG
Network Portal - Gene CAC0083
Allopurinol Hexal : Uses, Side Effects, Interactions, Dosage / Pillintrip
... adenine phosphoribosyltransferase.. Allopurinol Hexal is indicated for the management of 2,8-dihydroxyadenine (2,8-DHA) renal ... adenine phosphoribosyltransferase. Allopurinol Hexal is indicated for the management of 2,8-dihydroxyadenine (2,8-DHA) renal ... stones related to deficient activity of adenine phosphoribosyltransferase.. Allopurinol Hexal is indicated for the management ... stones related to deficient activity of adenine phosphoribosyltransferase.. Allopurinol Hexal is indicated for the management ...
protein deficiency
STEPdb: Sub-cellular Topologies of E.coli Polypeptides.
List of EC numbers (EC 2)
adenine phosphoribosyltransferase. *: hypoxanthine phosphoribosyltransferase. *: uracil phosphoribosyltransferase. *: orotate ... nicotinate phosphoribosyltransferase. *: nicotinamide phosphoribosyltransferase. *: now EC 2.5.1.6. *: ... rRNA (adenine-N6-)-methyltransferase. *: amine N-methyltransferase. *: loganate O-methyltransferase. *: rRNA (guanine-N1-)- ... tRNA (adenine-N1-)-methyltransferase. *: DNA (cytosine-5-)-methyltransferase. *: O-demethylpuromycin O-methyltransferase. *: ...
MEPACO - MEPACO
... adenine phosphoribosyltransferase.. Uric Pure is indicated for the management of 2,8-dihydroxyadenine (2,8-DHA) renal stones ... related to deficient activity of adenine phosphoribosyltransferase.. Uric Pure is indicated for the management of recurrent ... hypoxanthine-guanine phosphoribosyltransferase, including Lesch-Nyhan syndrome; glucose-6-phosphatase including glycogen ...
APRTHypoxanthine-guanine phosphoribosyltraPhosphoribosyl transferaseDeficiencyEnsemblXanthine oxidasePhosphoribosylpyrophosphateAdenosineEnzymeAmineGuanineInterproscanPurineSalvagePurinesMoleculeActivityIncludeNAMPTDeficiencyEnzymesDinucleotidePathwayNucleotide translocatorPhosphateMitochondriaUracilEnzyme calledGeneNicotinateCytosineCellsRenalFunctionalForm
APRT6
- Adenine phosphoribosyltransferase (APRT) deficiency is an inherited condition that affects the kidneys and urinary tract. (medlineplus.gov)
- This gene provides instructions for making APRT, an enzyme that helps to convert a DNA building block (nucleotide) called adenine to a molecule called adenosine monophosphate (AMP). (medlineplus.gov)
- Significant alterations to treatment were indicated for 2 (unrelated) patients with previously undiagnosed Adenine Phosphoribosyltransferase (APRT) Deficiency, for whom treatment with xanthine oxidase inhibitor was initiated to reduce risk of graft damage and loss. (asn-online.org)
- Adenine phosphoribosyl transferase (APRT) deficiency is a rare genetic condition that often presents with recurrent dihydroxyadenine (DHA) urolithiasis. (wjnu.org)
- Formation of 2,8-dihydroxyadenine (DHA) stones is a rare form of urolithiasis that occurs in patients with adenine phosphoribosyl transferase (APRT) deficiency. (wjnu.org)
- The 2,8-DHA is the end product of adenine metabolism by xanthine oxidase in the absence of APRT ( Fig. 2 ). (wjnu.org)
Hypoxanthine-guanine phosphoribosyltra2
- Deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity is an inborn error of purine metabolism associated with uric acid overproduction and a continuum spectrum of neurological manifestations depending on the degree of the enzymatic deficiency. (biomedcentral.com)
- Group 1: The patient may have deficiencies in hypoxanthine-guanine phosphoribosyltransferase (HGPRT), adenine phosphoribosyltransferase, or xanthine dehydrogenase enzymes. (medscape.com)
Phosphoribosyl transferase1
- Mutations affecting adenine phosphoribosyl transferase activity in Chinese hamster cells. (wikidata.org)
Deficiency3
- Edvardsson VO, Sahota A, Palsson R. Adenine Phosphoribosyltransferase Deficiency. (medlineplus.gov)
- The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). (mayo.edu)
- In adenosine deaminase deficiency, adenosine and adenine accumulate in the plasma. (medscape.com)
Ensembl1
- xanthine-guanine phosphoribosyltransferase [Ensembl]. (ntu.edu.sg)
Xanthine oxidase1
- Degradation of adenine occurs in several steps, first enzyme purine nucleoside phosphorylase converts adenosine into inosine which in the presence of enzyme xanthine oxidase is converted to hypoxanthine that is finally metabolised into uric acid. (biologybard.com)
Phosphoribosylpyrophosphate1
- An enzyme catalyzing the formation of AMP from adenine and phosphoribosylpyrophosphate. (bvsalud.org)
Adenosine1
- The nucleosides of adenine include deoxyadenosine and adenosine. (biologybard.com)
Enzyme4
- A lack of functional enzyme impairs the conversion of adenine to AMP. (medlineplus.gov)
- It can act as a salvage enzyme for recycling of adenine into nucleic acids. (bvsalud.org)
- Enzyme adenine phosphoribosyltransferase aids in the salvaging of adenine formed and in its re-utilisation. (biologybard.com)
- A series of tests pointed to a specific enzyme called adipokine nicotinamide phosphoribosyltransferase, (NAMPT), which is known to be involved in some of the pathological metabolic problems caused by obesity. (eurekalert.org)
Amine1
- Adenine has an amine group at the 6th position and an additional double bond between C-6 and N-1 in its pyrimidine ring. (biologybard.com)
Guanine4
- Guanine and Adenine both are purine nucleobases but differ in their structure. (biologybard.com)
- Guanine pairs with cytosine with 3 hydrogen bonds while adenine pairs with thymine in DNA and in RNA it pairs complementary to Uracil with two hydrogen bonds. (biologybard.com)
- The level of 1-HP-adenine corresponded to 2% of 7-HP-guanine. (who.int)
- 1-HP-adenine is chemically more stable ( t 1/2 = 9.2 days for rearrangement to an N 6 adduct compared with t 1/2 = 5 days for depurination of 7-HP-guanine). (who.int)
Interproscan2
- Nicotinate phosphoribosyltransferase (NAPRTase) family, Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain [Interproscan]. (ntu.edu.sg)
- Ribosomal RNA adenine dimethylase [Interproscan]. (ntu.edu.sg)
Purine1
- Adenine is an organic purine nitrogenous base having the formula C 5 H 5 N 5 that complementarily pairs with thymine and uracil in RNA and DNA respectively. (biologybard.com)
Salvage1
- Modulation of adenine phosphoribosyltransferase‐mediated salvage pathway to accelerate diabetic wound healing. (visualprotein.com)
Purines1
- Adenine like other purines is an aromatic heterocyclic compound. (biologybard.com)
Molecule2
- As a result, adenine is converted to another molecule called 2,8-dihydroxyadenine (2,8-DHA). (medlineplus.gov)
- In the body, NAMPT exists in two forms: an intracellular form, which regulates the production of nicotinamide adenine dinucleotide (NAD+), an important molecule for the generation of energy in the cell. (eurekalert.org)
Activity1
- Allopurinol Hexal is indicated for the management of 2,8-dihydroxyadenine (2,8-DHA) renal stones related to deficient activity of adenine phosphoribosyltransferase. (pillintrip.com)
Include1
- Other compounds that comprise Adenine include co-factors like FAD and NAD. (biologybard.com)
NAMPT14
- 5. Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair. (nih.gov)
- We demonstrate that nicotinamide phosphoribosyltransferase (Nampt), the equivalent enzyme in nicotinamide recycling to NAD + in vertebrates,can functionally substitute for PNC-1. (biologists.com)
- OBJECTIVE: The nicotinamide phosphoribosyltransferase (Nampt) inhibitor APO866 depletes intracellular nicotinamide adenine dinucleotide (NAD(+)) and shows promising anticancer activity in preclinical studies. (unige.it)
- A70: NAM is converted to nicotinamide mononucleotide (NMN) by nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12) (PMID: 19403820). (nih.gov)
- A17: The rate-limiting protein in the conversion of NAM back to NAD+ is nicotinamide phosphoribosyltransferase (NAMPT), which catalyzes the reaction of nicotinamide into nicotinamide mononucleotide (NMN). (nih.gov)
- NAD + biosynthesis via nicotinamide phosphoribosyltransferase (NAMPT) modulates SIRT1 activity. (esmo.org)
- The results indicate that poly (ADP-ribose) polymerase (PARP) inhibitors synergized with nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. (nih.gov)
- This result was explained by the observation that the NAMPT enzyme is the rate-limiting enzyme involved in the nicotinamide adenine dinucleotide (NAD+) salvage pathway, a necessary substrate of PARP. (nih.gov)
- It is known that sirtuin activity is controlled by NAD pathways and nicotinamide phosphoribosyltransferase (NAMPT). (calerie.com)
- NAMPT also named as Pre-B-cell colony-enhancing factor (PBEF) or visfatin, which is a limiting enzyme in the nicotinamide adenine dinucleotide (NAD+) salvage biosynthetic pathway. (paft-phil.com)
- A series of tests pointed to a specific enzyme called adipokine nicotinamide phosphoribosyltransferase, (NAMPT), which is known to be involved in some of the pathological metabolic problems caused by obesity. (babiesbooksandbeyond.com)
- In the body, NAMPT exists in two forms: an intracellular form, which regulates the production of nicotinamide adenine dinucleotide (NAD+), an important molecule for the generation of energy in the cell. (babiesbooksandbeyond.com)
- Nevertheless, its conversion to NAD+ depends on rate-limiting enzymes like nicotinamide phosphoribosyltransferase (NAMPT). (wellnessdoctorrx.com)
- Nicotinamide phosphoribosyltransferase is the enzyme that produces NMN in the human body (NAMPT). (antibodybiotech.com)
Deficiency2
- Adenine phosphoribosyltransferase deficiency is a genetic disease, which means that it is caused by one or more genes not working correctly. (nih.gov)
- Edvardsson VO, Sahota A, Palsson R. Adenine Phosphoribosyltransferase Deficiency. (medlineplus.gov)
Enzymes2
- Nicotinamide adenine dinucleotide (NAD + ) is a central molecule in cellular metabolism and an obligate co-substrate for NAD + -consuming enzymes, which regulate key biological processes such as longevity and stress responses. (biologists.com)
- Nicotinamide adenine dinucleotide (NAD + ) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on healthspan. (ultranmn.com)
Dinucleotide14
- Nicotinamide adenine dinucleotide (NAD + ) is a crucial reductant in cellular biochemistry. (biologists.com)
- A report in the journal CELL noted that the use of a derivative of vitamin B3/niacin called nicotinamide stimulates the production of nicotinamide adenine dinucleotide (NAD), a key protein in cellular metabolism (use of sugar for cellular energy) and cellular respiration (use of oxygen for cellular energy) in the mitochondria of cells. (resveratrolnews.com)
- Nicotinic acid (NA) and nicotinamide (NAM) are major forms of niacin and exert their physiological functions as precursors of nicotinamide adenine dinucleotide (NAD). (resveratrolnews.com)
- We reported that SIRT1, a nicotinamide adenine dinucleotide (NAD + )-dependent histone/protein deacetylase, is highly expressed in primary acute-type ATL cells. (esmo.org)
- Mumumuviri, NMN inoshandiswa kugadzira nicotinamide adenine dinucleotide (NAD +), yakasimba uye yakakosha mamorekuru inowanikwa mune yese sero yemuviri. (aasraw.com)
- NAD inomirira nicotinamide adenine dinucleotide. (aasraw.com)
- It has been shown that the activity of nicotinamide adenine dinucleotide (NAD+) is related with the decline of Aβ toxicity in AD. (nih.gov)
- This work incorporates our unique resource of treatment-naïve and treatment-resistant models to examine the role of NAD + (nicotinamide adenine dinucleotide) production, which is critical for energy use in these tumors, and how blocking this process may provide an innovative treatment approach. (thecurestartsnow.org)
- Although neurons developed normally, mice without TOP1 showed motor deficits, exhibited lower levels of nicotinamide adenine dinucleotide (NAD-plus) - a compound critical in energy metabolism - and died prematurely. (nih.gov)
- It is a building block for nicotinamide adenine dinucleotide (NAD). (calerie.com)
- Sirtuins consist of 7 different proteins dependent on nicotinamide adenine dinucleotide (NAD+) that modulate DNA by expression and aging. (wellnessdoctorrx.com)
- This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. (nih.gov)
- May 03, 2017 · Nicotinamide adenine dinucleotide has 3 related precursor vitamins - nicotinamide, nicotinic acid, and nicotinamide riboside - that have highly efficient synthetic and recycling 'salvage' pathways and one 'detoxification' pathway using nicotinamide N-methyltransferase (NNMT). (metfur.pro)
- May 31, 2020 · Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits mediated via elevated NAD+ content in the body. (metfur.pro)
Pathway1
- We've investigated the potential of the GTP synthesis pathways as chemotherapeutic goals in the individual pathogen GTP biosynthesis, however, not the alternative salvage pathway, is crucial to cryptococcal dissemination and success pathway leads to slow development and virulence aspect defects, while lack of the cognate phosphoribosyltransferase in the salvage pathway yielded no phenotypes. (stopvivisection.info)
Nucleotide translocator1
- Adenine nucleotide translocator 2. (lookformedical.com)
Phosphate2
- An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. (lookformedical.com)
- adenine_ribotide_phosphate = 2 reactions were found. (tu-bs.de)
Mitochondria1
- Specifically, it blocks adenine nucleotide efflux from mitochondria by enhancing membrane binding. (lookformedical.com)
Uracil3
- In DNA, thymine complementary pairs with adenine whereas in RNA, uracil matches with adenine. (biologyonline.com)
- Instead of uracil, DNA has thymine that complementary pairs with adenine. (biologyonline.com)
- HPcytosine will spontaneously convert to N 6-HP-adenine and 3-HP-uracil, respectively. (who.int)
Enzyme called1
- The enzyme called phosphoribosyltransferases (PRT) catalyzes the salvaging of purines. (dreamtech.nl)
Gene1
- Add to 10265: Adenine B auxotroph, human complement for hamster Studying hybrids between hamster cells carrying induced auxotrophic mutation and normal human cells, Kao and Puck (1972) defined a linkage between an adenine B auxotroph complementing gene and a gene necessary for expression of three esterase bands (13335). (nih.gov)
Nicotinate1
- 14. Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors. (nih.gov)
Cytosine2
- Hypoxanthine, in particular, may faulty base pairs with cytosine because of its likeness to adenine (which pairs up naturally with thymine). (biologyonline.com)
- 3-HP-, 1-HP-adenine, and 3-HP-cytosine. (who.int)
Cells1
- The intriguing findings of our preliminary studies support a hypothesis that treatment-resistant cells have strong dependence on mediators of NAD + production, such as the enzyme QPRT (quinolinic acid phosphoribosyltransferase). (thecurestartsnow.org)
Renal1
- Zyloric is indicated for the management of 2,8-dihydroxyadenine (2,8-DHA) renal stones related to deficient activity of adenine phosphoribosyltransferase. (medicines.org.uk)
Functional1
- A lack of functional enzyme impairs the conversion of adenine to AMP. (medlineplus.gov)
Form1
- Hypoxanthine may form from spontaneous deamination of adenine. (biologyonline.com)