AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Adenine PhosphoribosyltransferasePentosyltransferasesHypoxanthine PhosphoribosyltransferaseAdenineHypoxanthinesPhosphoribosyl PyrophosphateOrotate PhosphoribosyltransferaseChromosomes, Human, 16-18Nicotinamide PhosphoribosyltransferaseAzaserinePurinesLesch-Nyhan SyndromePentosephosphatesATP PhosphoribosyltransferasePurine-Nucleoside PhosphorylaseCarcinoma, Ehrlich TumorAdenosine MonophosphateAnthranilate PhosphoribosyltransferaseCricetinaeNucleotidesMutationHeterozygote DetectionHybrid CellsGenesBase SequenceAzaguaninePurine-Pyrimidine Metabolism, Inborn ErrorsCricetulusMolecular Sequence DataBlotting, SouthernGlucosyltransferasesKineticsAdenine NucleotidesDNACHO CellsErythrocytesCell LineAllelesAcrylamidesNicotinamide MononucleotideAmino Acid SequenceHypoxanthine
Adenine Phosphoribosyltransferase
An enzyme catalyzing the formation of AMP from adenine and phosphoribosylpyrophosphate. It can act as a salvage enzyme for recycling of adenine into nucleic acids. EC 2.4.2.7.
Pentosyltransferases
Enzymes of the transferase class that catalyze the transfer of a pentose group from one compound to another.
Hypoxanthine Phosphoribosyltransferase
An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
Adenine
A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
Hypoxanthines
Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.
Phosphoribosyl Pyrophosphate
The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
Orotate Phosphoribosyltransferase
The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the course of pyrimidine nucleotide biosynthesis. EC 2.4.2.10.
Chromosomes, Human, 16-18
The short, submetacentric human chromosomes, called group E in the human chromosome classification. This group consists of chromosome pairs 16, 17, and 18.
Nicotinamide Phosphoribosyltransferase
An enzyme that catalyzes the formation of nicotinamide mononucleotide (NMN) from nicotinamide and 5-phosphoribosyl-1-pyrophosphate, the rate-limiting step in the biosynthesis of the NAD coenzyme. It is also known as a growth factor for early B-LYMPHOCYTES, or an ADIPOKINE with insulin-mimetic effects (visfatin).
Azaserine
Antibiotic substance produced by various Streptomyces species. It is an inhibitor of enzymatic activities that involve glutamine and is used as an antineoplastic and immunosuppressive agent.
Purines
A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
Lesch-Nyhan Syndrome
An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
Pentosephosphates
ATP Phosphoribosyltransferase
An enzyme that catalyzes the first step of the pathway for histidine biosynthesis in Salmonella typhimurium. ATP reacts reversibly with 5-phosphoribosyl-1-pyrophosphate to yield N-1-(5'-phosphoribosyl)-ATP and pyrophosphate. EC 2.4.2.17.
Purine-Nucleoside Phosphorylase
An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free purine plus ribose-5-phosphate. EC 2.4.2.1.
Carcinoma, Ehrlich Tumor
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
Adenosine Monophosphate
Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
Anthranilate Phosphoribosyltransferase
An enzyme that catalyzes the formation of N-5'-phosphoribosylanthranilic acid from anthranilate and phosphoribosylpyrophosphate, the first step in tryptophan synthesis in E. coli. It exists in a complex with ANTHRANILATE SYNTHASE in bacteria. EC 2.4.2.18.
Cricetinae
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Nucleotides
The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Heterozygote Detection
Identification of genetic carriers for a given trait.
Hybrid Cells
Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.
Genes
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Azaguanine
One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.
Purine-Pyrimidine Metabolism, Inborn Errors
Cricetulus
A genus of the family Muridae consisting of eleven species. C. migratorius, the grey or Armenian hamster, and C. griseus, the Chinese hamster, are the two species used in biomedical research.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Blotting, Southern
A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
Glucosyltransferases
Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.
Kinetics
The rate dynamics in chemical or physical systems.
Adenine Nucleotides
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
CHO Cells
CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.
Erythrocytes
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Alleles
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Acrylamides
Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.
Nicotinamide Mononucleotide
3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose. Synonyms: Nicotinamide Ribonucleotide; NMN.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Hypoxanthine
A purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.

Developmental changes in purine phosphoribosyltransferases in human and rat tissues. (1/221)

1. The hypoxanthine/guanine and adenine phosphoribosyltransferase activities in a wide variety of human tissues were studied during their growth and development from foetal life onward. A wide range of activities develop after birth, with especially high values in the central nervous system and testes. 2. Postnatal development of hypoxanthine/guanine phosphoribosyltransferase was also defined in the rat. Although there were increases in the central nervous system and testes, there was also a rise in activity in the liver, which was less marked in man. 3. A sensitive radiochemical assay method, using dTTP to inhibit 5'-nucleotidase activity, suitable for tissue extracts, was developed. 4. No definite evidence of the existence of tissue-specific isoenzymes of hypoxanthine/guanine or adenine phosphoribosyltransferase was found. Hypoxanthine/guanine phosphoribosyltransferase in testes, however, had a significantly different thermal-denaturation rate constant. 5. The findings are discussed in an attempt to relate activity of hypoxanthine/guanine phosphoribosyltransferase to biological function. Growth as well as some developmental changes appear to be related to increase in the activity of this enzyme.  (+info)

A novel signature mutation for oxidative damage resembles a mutational pattern found commonly in human cancers. (2/221)

To determine the types of mutations induced by oxidative damage, a kidney cell line with a heterozygous deficiency for the autosomal Aprt (adenine phosphoribosyltransferase) gene was tested for its mutagenic response to hydrogen peroxide. Aprt-deficient cells were selected and scored for loss of heterozygosity (LOH) for 11 microsatellite loci on mouse chromosome 8. On the basis of the LOH analysis, spontaneous mutants (n = 38) were distributed into four classes: apparent point mutation, mitotic recombination, chromosome loss, and large interstitial deletion. However, 9 of 20 (45%) hydrogen peroxide-induced mutants exhibited a novel class of mutations characterized by "discontinuous LOH" for one or more of the microsatellite loci. Interestingly, mutations resembling discontinuous LOH are commonly observed in a wide variety of human cancers. Our data suggest that discontinuous LOH is a signature mutational pattern for oxidative damage and further suggest that such genetic damage is widespread in cancer.  (+info)

Effect of interferon-gamma on purine catabolic and salvage enzyme activities in rats. (3/221)

To determine whether interferon-gamma affects rat purine catabolic and salvage enzyme activities, rats were injected with interferon-gamma (600000 U/kg, i.p.) and, similarly to a vehicle-injected control group, killed before or after injection at 6, 12, and 24 h. Organ homogenates were prepared and enzymatic reactions with substrates were carried out, after which the products were measured either chromatographically or spectrophotometrically. Western and Northern blotting also were performed. In contrast to the vehicle-injected rats, interferon-gamma-injected rats showed a significant rise in xanthine oxidoreductase activity in the liver, while enzyme activity was unchanged in the spleen, kidney, and lung. Western analysis of hepatic xanthine oxidoreductase showed an increased concentration of this protein 12 and 24 h after interferon-gamma injection. Northern analysis disclosed an enhanced mRNA expression coding for this enzyme, peaking 12 h after injection. Contrastingly, the activities of adenosine deaminase, purine nucleoside phosphorylase, hypoxanthine guanine phosphoribosyltransferase, and adenine phosphoribosyltransferase were not affected by interferon-gamma in any organ tested. While interferon-gamma causes an increased hepatic biosynthesis of xanthine oxidoreductase, the physiologic role of this enzyme induction remains undetermined.  (+info)

Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani. (4/221)

The enzyme adenine phosphoribosyltransferase (APRT) functions to salvage adenine by converting it to adenosine-5-monophosphate (AMP). APRT deficiency in humans is a well characterized inborn error of metabolism, and APRT may contribute to the indispensable nutritional role of purine salvage in protozoan parasites, all of which lack de novo purine biosynthesis. We determined crystal structures for APRT from Leishmania donovani in complex with the substrate adenine, the product AMP, and sulfate and citrate ions that appear to mimic the binding of phosphate moieties. Overall, these structures are very similar to each other, although the adenine and AMP complexes show different patterns of hydrogen-bonding to the base, and the active site pocket opens slightly to accommodate the larger AMP ligand. Whereas AMP adopts a single conformation, adenine binds in two mutually exclusive orientations: one orientation providing adenine-specific hydrogen bonds and the other apparently positioning adenine for the enzymatic reaction. The core of APRT is similar to that of other phosphoribosyltransferases, although the adenine-binding domain is quite different. A C-terminal extension, unique to Leishmania APRTs, extends an extensive dimer interface by wrapping around the partner molecule. The active site involves residues from both subunits of the dimer, indicating that dimerization is essential for catalysis.  (+info)

Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice. (5/221)

Mice heterozygous at Aprt (adenine phosphoribosyltransferase) were used as a model to study in vivo loss of heterozygosity (LOH) in normal fibroblasts. Somatic cell variants that exhibited functional loss of the wild-type Aprt in vivo were recovered as APRT-deficient cell colonies after culturing in selection medium containing 2, 6-diaminopurine (DAP), an adenine analog that is toxic only to cells with APRT enzyme activity. DAP-resistant (DAP(r)) fibroblast variants were recovered at a median frequency of 12 x 10(-5) from individual ears from progeny of crosses between mouse strains 129/Sv and C3H/HeJ. The frequency of DAP(r) variants varied greatly among individual ears, suggesting that they preexisted in vivo and arose at various times during development. Polymorphic molecular markers and a cytological marker on the centromere of chromosome 8 made it possible to discriminate between each of six possible mechanistic pathways of LOH. The majority (about 80%) of the DAP(r) variants were a consequence of mitotic recombination. The prevalence of mitotic recombination in regions proximal to Aprt did not correlate with meiotic map distances. In particular, there was a higher than expected frequency of crossovers within the interval 59 cM to 67 cM. The high spontaneous frequency of Aprt LOH, mediated primarily by mitotic recombination, is fully consistent with our previous results with human peripheral T cells from individuals known to be heterozygous at APRT. Thus, this Aprt heterozygote mouse is a valid model for studying somatic mutagenesis and mitotic recombination in vivo.  (+info)

Enhanced amsacrine-induced mutagenesis in plateau-phase Chinese hamster ovary cells, with targeting of +1 frameshifts to free 3' ends of topoisomerase II cleavable complexes. (6/221)

Previous work showed that the DNA double-strand cleaving agents bleomycin and neocarzinostatin were more mutagenic in plateau-phase than in log-phase cells. To determine whether topoisomerase II poisons that produce double-strand breaks by trapping of cleavable complexes would, likewise, induce mutations specific to plateau-phase cells, aprt mutations induced by amsacrine in both log-phase and plateau-phase CHO cells were analyzed. The maximum aprt mutant frequencies obtained were 7 x 10(-6) after treatment with 0.02 microM amsacrine in log phase and 27 x 10(-6) after treatment with 1 microM amsacrine in plateau phase, compared with a spontaneous frequency of < 1 x 10(-6). Base substitutions dominated the spectrum of mutations in log-phase cells, but were much less prevalent in plateau-phase cells. Both spectra also included small deletions, insertions and duplications, as well as few large-scale deletions or rearrangements. About 5% of the log-phase mutants and 16% of the plateau-phase mutants were +1 frameshifts, and all but one of these were targeted to potential free 3' termini of cleavable complexes, as determined by mapping of cleavage sites in DNA treated with topoisomerase II plus amsacrine in vitro. Thus, these insertions may arise from templated extension of the exposed 3' terminus by a DNA polymerase, followed by resealing of the strand, as shown previously for acridine-induced frameshifts in T4 phage.  (+info)

Solid tissues removed from ATM homozygous deficient mice do not exhibit a mutator phenotype for second-step autosomal mutations. (7/221)

The presence of increased frequencies of blood-derived and solid tumors in ataxia-telangiectasia (A-T) patients, coupled with a role for the ATM (A-T mutation) protein in detecting specific forms of DNA damage, has led to the assumption of a mutator phenotype in A TM-deficient cells. Supporting this assumption are observations of increased rates of chromosomal aberrations and intrachromosomal homologous recombinational events in the cells of A-T patients. We have bred mice with knockout mutations for the selectable Aprt (adenine phosphoribosyltransferase) locus and the Atm locus to examine the frequency of second-step autosomal mutations in Atm-deficient cells. Two solid tissues were examined: (a) the ear, which yields predominately mesenchymal cells; and (b) the kidney, which yields predominately epithelial cells. We report here the lack of a mutator phenotype for inactivating autosomal mutations in solid tissues of the Atm-deficient mice.  (+info)

Localized Derepression on the Human Inactive X Chromosone in Mouse-Human Cell Hybrids. (8/221)

Evidence for derepression of the gene for hypoxanthine phosphoribosyltransferase (HPRT; IMP: pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) on the human inactive X chromosome was obtained in hybrids of mouse and human cells. The mouse cells lacked HPRT and were also deficient in adenine phosphoribosyltransferase (APRT; AMP: pyrophosphate phosphoribosyltransferase; EC2.4.2.7). The human female fibroblasts were HPRT-deficient as a consequence of a mutation on the active X but contained a normal HPRT gene on the inactive X. The two human X chromosomes were further distinguished by differences in morphology: the inactive X was morphologically normal while the active X included most of the long arm of autosome no. 1 translocated to the distal end of the X long arm. Forty-one hybrid clones were first isolated by selection for the presence of APRT; when these clones were selected for HPRT, six of them yielded derivatives having human HPRT with incidences of about 1 in 10-6 APRT-selected hybrid cells. The HPRT-positive derivatives contained a normal-appearing X chromosome indistinguishable from the inactive X of the parental human fibroblasts. The active X with the translocation was not found in any of the HPRT-positive hybrid cells. Human phosphoglycerokinase (ATP:3-phospho-D-glycerate 1-phosphotransferase. EC 2.7.2.3) and glucose-6-phosphate dehydrogenase (D-glucose 6-phosphate: NADP 1-oxidoreductase, EC 1.1.1.49), which are specified by X-chromosomal loci, were not detected in the hybrids expressing HPRT even though they contained an apparently intact X chromosome. The observations are most simply explained by the infrequent, stable derepression of inactive X chromosome segments that include the HPRT locus but not the phosphoglycerokinase and glucose-6-phosphate dehydrogenase loci.  (+info)

Adenine Phosphoribosyltransferase Deficiency Symptoms, Doctors, Treatments, Advances & More | MediFindAdenine Phosphoribosyltransferase Deficiency Symptoms, Doctors, Treatments, Advances & More | MediFind
Find everything you need to know about Adenine Phosphoribosyltransferase Deficiency including doctors, latest advances, and ongoing clinical trials.
https://www.medifind.com/conditions/adenine-phosphoribosyltransferase-deficiency/116
Model involving gene inactivation in the generation of autosomal recessive mutants in mammalian cells in culture - UC Davis
TY - JOUR. T1 - Model involving gene inactivation in the generation of autosomal recessive mutants in mammalian cells in culture. AU - Simon, A. E.. AU - Taylor, M. W.. AU - Bradley, W. E C. AU - Thompson, L. H.. PY - 1982. Y1 - 1982. N2 - We present evidence for a two-step model for expression of the recessive phenotype at the diploid adenine phosphoribosyl transferase (aprt) locus in Chinese hamster ovary cells. This model proposes a high-frequency event leading to allelic inactivation and a low-frequency event leading to a structural alteration of the APRT protein. Either event can occur first, resulting in two types of heterozygous cells. The proposed model is based on analysis of Chinese hamster ovary presumptive aprt heterozygotes and APRT- mutants, derived by two different laboratories. The major class of heterozygotes (class 1) had approximately 50% parental APRT activity, 50% immunologically precipitable APRT protein, and only wild-type enzyme as based on two-dimensional gel ...
https://ucdavis.pure.elsevier.com/en/publications/model-involving-gene-inactivation-in-the-generation-of-autosomal-/
UniProtKB/SwissProt variant VAR 069051UniProtKB/SwissProt variant VAR 069051
Adenine phosphoribosyltransferase deficiency (APRTD) [MIM:614723]: An enzymatic deficiency that can lead to urolithiasis and renal failure. Patients have 2,8-dihydroxyadenine (DHA) urinary stones. {ECO:0000269,PubMed:11243733, ECO:0000269,PubMed:1353080, ECO:0000269,PubMed:15571218, ECO:0000269,PubMed:1746557, ECO:0000269,PubMed:21635362, ECO:0000269,PubMed:3343350, ECO:0000269,PubMed:3680503, ECO:0000269,PubMed:7915931}. Note=The disease is caused by mutations affecting the gene represented in this entry ...
http://web.expasy.org/variant_pages/VAR_069051.html
2,8- Dihydroxyadenine Urinary Stones | College of Veterinary Medicine - University of Minnesota2,8- Dihydroxyadenine Urinary Stones | College of Veterinary Medicine - University of Minnesota
Canine 2,8-dihydroxyadenine (2,8-DHA) urinary stones are caused by an autosomal recessive genetic disorder. The disorder is a result of a mutation in the adenine phosphoribosyltransferase (APRT) gene, which encodes an enzyme that is critical in the metabolism of dietary purines. A deficiency in APRT results in excessive 2,8-DHA in the urine. This increases the risk for formation of bladder or kidney stones and can cause significant kidney disease. Who gets it?2,8-DHA is among the most rare types of canine urinary stones. It has been reported in dogs with ancient breed origins, such as the Siberian Husky, Tamaskan, and Native American Indian Dog (which is derived from the Alaskan Malamute, Siberian Husky, German Shepherd Dog, and Chinook). We have also identified this stone type in wolves.What are the clinical signs? Canine 2,8-DHA stones can form in the kidneys or bladder. This causes irritation that may manifest as straining to urinate, frequent urination, urgency with urination, blood in the urine, or
https://vetmed.umn.edu/research/labs/canine-genetics-lab/canine-genetic-testing/28-dihydroxyadenine-urolithiasis
Plus itPlus it
We have investigated whether the presence of a DNA repair enzyme, 06-methylguanine-DNA-methyltransferase (MGMT), affects the nature of spontaneous mutations in a mammalian cell line. We compared spontaneous mutations in the adenine phosphoribosyl transferase gene of a Chinese hamster ovary (CHO) cell line that expressed 14,000 MGMT molecules/cell with those in the parental CHO cells lacking this DNA repair activity. The mutation rate/cell/generation of the two CHO cell lines did not differ significantly. However, DNA sequence analysis of spontaneous mutations in the MGMT-proficient CHO cell line revealed a complex picture. No significant difference from the parental CHO cells was found in the number or type of deletions, frame-shifts, multiple substitutions, or insertions. The frequency of G:C to T:A transversions was elevated in MGMT-proficient CHO cells. Expression of the enzyme considerably reduced G:C to A:T transitions (25% versus 8.3%). This latter result is the first evidence that this ...
http://cancerres.aacrjournals.org/content/52/23/6471
SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA - Patent applicationSYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA - Patent application
0248] The term analyte, as used herein, is a broad term and is used in its ordinary sense, including, without limitation, to refer to a substance or chemical constituent in a biological fluid (for example, blood, interstitial fluid, cerebral spinal fluid, lymph fluid or urine) that can be analyzed. Analytes may include naturally occurring substances, artificial substances, metabolites, and/or reaction products. In some embodiments, the analyte for measurement by the sensor heads, devices, and methods is analyte. However, other analytes are contemplated as well, including but not limited to acarboxyprothrombin; acylcarnitine; adenine phosphoribosyl transferase; adenosine deaminase; albumin; alpha-fetoprotein; amino acid profiles (arginine (Krebs cycle), histidine/urocanic acid, homocysteine, phenylalanine/tyrosine, tryptophan); andrenostenedione; antipyrine; arabinitol enantiomers; arginase; benzoylecgonine (cocaine); biotinidase; biopterin; c-reactive protein; carnitine; carnosinase; CD4; ...
http://www.patentsencyclopedia.com/app/20120283541
OriGene - APRT (NM 000485) Human ORF cDNA CloneOriGene - APRT (NM 000485) Human ORF cDNA Clone
APRT - APRT (Myc-DDK-tagged)-Human adenine phosphoribosyltransferase (APRT), transcript variant 1 available for purchase from OriGene - Your Gene Company.
http://www.origene.com/orf_clone/trueclone/NM_000485/RC216874/APRT.aspx
Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend...Hypoxanthine incorporation and nucleotide imbalance in wild-type and adenine phosphoribosyl transferase-deficient Friend...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.biochemsoctrans.org/content/18/4/618.1
Cloning, expression and biochemical characterization of xanthine and adenine phosphoribosyltransferases from thermus...
Purine phosphoribosyltransferases, purine PRTs, are essential enzymes in the purine salvage pathway of living organisms. They are involved in the formation of C-N glycosidic bonds in purine nucleosides-50-monophosphate (NMPs) through the transfer of the 5-phosphoribosyl group from 5-phospho-a-D-ribosyl-1-pyrophosphate (PRPP) to purine nucleobases in the presence of Mg2þ. Herein, we report a simple and thermostable process for the one-pot, one-step synthesis of some purine NMPs using xanthine phosphoribosyltransferase, XPRT or adenine phosphoribosyltransferase, APRT2, from Thermus thermophilus HB8. In this sense, the cloning, expression and purification of TtXPRT and TtAPRT2 is described for the first time. Both genes, xprt and aprt2 were expressed as his-tagged enzymes in E. coli BL21(DE3) and purified by a heat-shock treatment, followed by Ni-affinity chromatography and a final, polishing gel-filtration chromatography. Biochemical characterization revealed TtXPRT as a tetramer and TtAPRT2 as a ...
http://abacus.universidadeuropea.es/handle/11268/6505
RT² qPCR Primer Assay for Mouse AprtRT² qPCR Primer Assay for Mouse Aprt
The RT² qPCR Primer Assay is the most reliable SYBR® Green-based quantitative real-time PCR assay for gene expression analysis. Our experimentally verified design algorithm yields gene-specific qPCR assays characterized by uniform and high PCR efficiencies and standardized amplification conditions. Every RT² Primer Assay is subjected to rigorous experimental verification. Single product amplification of the correct size and high PCR efficiency are guaranteed when using the appropriate RT² qPCR Master Mixes. The uniform PCR amplification efficiencies and PCR conditions of the RT² qPCR Primer Assays provide an accurate and scalable solution for multiple gene expression analyses. Browse Primer Assays By Gene ...
http://www.sabiosciences.com/primerinfo.php?pcatn=PPM24709A
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2734 DNA CpG island hypermethylation is a very common alteration in cancer, the genesis of which is still unrevealed. It has been proposed that, with aging and carcinogenesis, DNA methylation spreads from normally methylated regions (methylation centers) into gene promoters, resulting in silencing. Candidate sequences to act as methylation centers are the widely spread Alu repeats. In order to test this hypothesis and establish models of in-vitro methylation, we cloned fragments of the murine promoters cdkn2d (-634 to +432) and p19ARF (-1088 to +419) into the reporter vector pGL3-basic which contains the Luciferase gene (wild-type constructs) and added B1 repetitive elements (murine Alu) in tandem 2, 4 and 6 times upstream to these promoters, resulting in 7 different transgenic cassettes that were transiently and/or stably integrated into the fibroblast cell line NIH3T3. No or little decrease in luciferase activity was detected for all wild-type constructs at 48 and 72 hours after transient ...
http://cancerres.aacrjournals.org/content/65/9_Supplement/643.3
All transcript variants in gene APRT - Whole genome datasets
DB-ID: Database ID of variant, grouping multiple observations of the same variant together, starting with the HGNC gene symbol, followed by an underscore (_) and a six digit number (e.g. DMD_012345). _000000 is used for variants where DNA was not analysed (change predicted from RNA analysis), variants seen in animal models or variants not seen in humans but functionally tested in vitro ...
https://databases.lovd.nl/whole_genome/variants/APRT
Human hg38 chr20:49,493,874-49,578,170 UCSC Genome Browser v395Human hg38 chr20:49,493,874-49,578,170 UCSC Genome Browser v395
Click on a feature for details. Click or drag in the base position track to zoom in. Click side bars for track options. Drag side bars or labels up or down to reorder tracks. Drag tracks left or right to new position. Press ? for keyboard shortcuts ...
http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&hgt.customText=http://www.genecards.org/all_genecards_v4.13.txt&position=chr20:49493874-49578170
Origin and Evolution of EukaryotesOrigin and Evolution of Eukaryotes
CSHL Press publishes monographs, technical manuals, handbooks, review volumes, conference proceedings, scholarly journals and videotapes. These examine important topics in molecular biology, genetics, development, virology, neurobiology, immunology and cancer biology. Manuscripts for books and for journal publication are invited from scientists world wide.
https://www.cshlpress.com/default.tpl?action=full&cart=1573282201685277850&--eqskudatarq=1010&typ=ps&newtitle=Origin%20and%20Evolution%20of%20Eukaryotes%20
Studies on the mechanism of 3-deazaguanine cytotoxicity in L1210-sensitive and -resistant cell lines<...
TY - JOUR. T1 - Studies on the mechanism of 3-deazaguanine cytotoxicity in L1210-sensitive and -resistant cell lines. AU - Singh, Gurcharn. AU - Luna, Marian K.. AU - Ardalan, Bach. PY - 1988/9/1. Y1 - 1988/9/1. N2 - 3-Deazaguanine (3-DG), a purine analogue, has unusual antitumor activity against experimental mammary tumor models and a number of other solid tumors. Others have shown that mutant CHO cells deficient in hypoxanthine guanine phosphoribosyl transferase (HGPRTase) or adenine phosphoribosyl transferase (APRTase) are resistant to 3-DG. We developed a L1210 cell line resistant to 3-DG, L1210/3-DG, by subculturing the parent L1210/0 cells in the presence of increasing concentrations of 3-DG. The IC50 was 3.5 μM and 620 μM for L1210/0 and L1210/3-DG, respectively. Cytotoxicity studies proved the resistance to be stable. Examination of the baseline-specific activity of HGPRTase and APRTase showed that the former was 118-fold lower in L1210/3-DG than in L1210/0, and the latter demonstrated ...
https://miami.pure.elsevier.com/en/publications/studies-on-the-mechanism-of-3-deazaguanine-cytotoxicity-in-l1210-
Search Results | SOAR (Scholarly Open Access at Rutgers)
AbstractMismatch repair (MMR) is critical for preserving genomic integrity. Failure of this system can accelerate somatic mutation and increase the risk of developing cancer. MSH6, in complex with MSH2, is the MMR protein that mediates DNA repair through the recognition of 1- and 2-bp mismatches. To evaluate the effects of MSH6 deficiency on genomic stability we compared the frequency of in vivo loss of heterozygosity (LOH) between MSH6-proficient and deficient, 129S2 x C57BL/6 F1 hybrid mice that were heterozygous for our reporter gene Aprt. We recovered mutant cells that had functionally lost APRT protein activity and categorized the spectrum of mutations responsible for the LOH events. We also measured the mutant frequency at the X-linked gene, Hprt, as a second reporter for point mutation. In Msh6-/-Aprt+/- mice, mutation frequency at Aprt was elevated in both T cells and fibroblasts by 2.5-fold and 5.7-fold, respectively, over Msh6+/+Aprt+/- littermate controls. While a modest increase in ...
https://soar.libraries.rutgers.edu/search-results?q1=%22Kucherlapati,%20Raju%22&q1field=facet:author&key=soar
2,8 DHA Crystalline Nephropathy - Arkana Laboratories2,8 DHA Crystalline Nephropathy - Arkana Laboratories
The renal biopsy shown here has crystals present within the tubular lumens and cytoplasm with a brownish appearance by H&E (A) that are strongly silver positive on the Jones methenamine silver stain (B). The crystals are birefringent when viewed under polarized light (C). These findings are characteristic of 2,8 DHA crystal deposition in the kidney resulting from a deficiency of adenine phosphoribosyltransferase. 2,8 dihydroxyadeninuria is an autosomal recessive disease resulting from pathogenic variants in the APRT gene. It is an important disease to recognize as treatment with a low purine diet and allopurinol therapy blocks formation of 2,8 DHA and can improve renal function. The differential diagnosis includes other crystalline nephropathies. One that is less well known but has a similar histopathology is triamterene crystalline nephropathy, which can be distinguished from 2,8 DHA by the presence of Maltese crosses under polarized light. ...
https://www.arkanalabs.com/28-dihydroxyadeninuria/
Plus itPlus it
6-Fluoro-3-hydroxy-2-pyrazinecarboxamide (T-705) is a novel antiviral compound with broad activity against influenza virus and diverse RNA viruses. Its active metabolite, T-705-ribose-5′-triphosphate (T-705-RTP), is recognized by influenza virus RNA polymerase as a substrate competing with GTP, giving inhibition of viral RNA synthesis and lethal virus mutagenesis. Which enzymes perform the activation of T-705 is unknown. We here demonstrate that human hypoxanthine guanine phosphoribosyltransferase (HGPRT) converts T-705 into its ribose-5′-monophosphate (RMP) prior to formation of T-705-RTP. The anti-influenza virus activity of T-705 and T-1105 (3-hydroxy-2-pyrazinamide; the analogue lacking the 6-fluoro atom) was lost in HGPRT-deficient MDCK cells. This HGPRT dependency was confirmed in human HEK293T cells undergoing HGPRT-specific gene knockdown followed by influenza virus ribonucleoprotein reconstitution. Knockdown for adenine phosphoribosyltransferase (APRT) or nicotinamide ...
http://molpharm.aspetjournals.org/content/early/2013/08/01/mol.113.087247
Hereditary causes of kidney stones and chronic kidney disease | SpringerLinkHereditary causes of kidney stones and chronic kidney disease | SpringerLink
Adenine phosphoribosyltransferase (APRT) deficiency, cystinuria, Dent disease, familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC), and primary hyperoxaluria (PH) are rare but imp
https://link.springer.com/article/10.1007/s00467-012-2329-z
Most recent papers with the keyword gigley | Read by QxMDMost recent papers with the keyword gigley | Read by QxMD
Type II Toxoplasma gondii KU80 knockouts (Δku80) deficient in nonhomologous end joining were developed to delete the dominant pathway mediating random integration of targeting episomes. Gene targeting frequency in the type II Δku80 Δhxgprt strain measured at the orotate (OPRT) and the uracil (UPRT) phosphoribosyltransferase loci was highly efficient. To assess the potential of the type II Δku80 Δhxgprt strain to examine gene function affecting cyst biology and latent stages of infection, we targeted the deletion of four parasite antigen genes (GRA4, GRA6, ROP7, and tgd057) that encode characterized CD8(+) T cell epitopes that elicit corresponding antigen-specific CD8(+) T cell populations associated with control of infection ...
https://www.readbyqxmd.com/keyword/101111
APRT 153B: CONTROL SYSTEMS & CUSTOMER SERVICE II (TAB-4) | Foothill CollegeAPRT 153B: CONTROL SYSTEMS & CUSTOMER SERVICE II (TAB-4) | Foothill College
B. An example of a written assignment is for a given DDC control situation, following testing, adjusting and balancing the system, to prepare a report for the customer and describe in writing how the work done, the report and recommendations will be presented to the customer ...
https://catalog.foothill.edu/course-outlines/APRT-153B/
SAOUHSC 00766 - AureoWikiSAOUHSC 00766 - AureoWiki
MetabolismPurines, pyrimidines, nucleosides, and nucleotidesSalvage of nucleosides and nucleotideshypoxanthine phosphoribosyltransferase (TIGR01203; EC 2.4.2.8; HMM-score: 22.2) ...
http://aureowiki.med.uni-greifswald.de/SAOUHSC_00766
NWMN RS06270 - AureoWikiNWMN RS06270 - AureoWiki
MetabolismPurines, pyrimidines, nucleosides, and nucleotidesSalvage of nucleosides and nucleotideshypoxanthine phosphoribosyltransferase (TIGR01203; EC 2.4.2.8; HMM-score: 44.3) ...
http://aureowiki.med.uni-greifswald.de/NWMN_RS06270
Ebook Investitionen, Unsicherheit Und Realoptionen
now, downstream data, issues, survivors, sites, data, and univariate representative RNAs could require purified via the ebook of outcomes. The ebook to enhance acid promoters with production is that the ECD-mTLR2 cell is full to introduce possible, there misconfigured to subscribe. respectively, ebook Investitionen, has acidic certain attB, and the network phosphoribosyltransferase is to be observed for a specifically new volume.
http://www.scoutconnection.com/wwwboard/ebook.php?q=ebook-Investitionen%2C-Unsicherheit-und-Realoptionen/
Allopurinol Tablets BP 100mgAllopurinol Tablets BP 100mg
Allopurinol is indicated for reducing urate/uric acid formation in conditions where urate/uric acid deposition has already occurred (e.g. gouty arthritis, skin tophi, nephrolithiasis) or is a predictable clinical risk (e.g. treatment of malignancy potentially leading to acute uric acid nephropathy). The main clinical conditions where urate/uric acid deposition may occur are: idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate levels occur either spontaneously, or after cytotoxic therapy; certain enzyme disorders which lead to overproduction of urate, for example: hypoxanthine-guanine phosphoribosyltransferase, including Lesch-Nyhan syndrome; glucose-6-phosphatase including glycogen storage disease; phosphoribosylpyrophosphate synthetase, phosphoribosylpyrophosphate amidotransferase; adenine phosphoribosyltransferase. Allopurinol is indicated for management of 2,8-dihydroxyadenine ...
https://www.medthority.com/drugs/m-musculo-skeletal-system/m04/m04a/m04aa/m04aa01/allopurinol-tablets-bp-100mg2/
The genetics of the Dras3-Roughened-ecdysoneless chromosomal region (62B3-4 to 62D3-4) in Drosophila melanogaster: analysis of...The genetics of the Dras3-Roughened-ecdysoneless chromosomal region (62B3-4 to 62D3-4) in Drosophila melanogaster: analysis of...
The genetic organization of interval 62B3-4 to 62D3-4 on the Drosophila third chromosome was investigated. The region (designated DRE) includes four known loci: Roughened (R; 3-1.4), defined by a dominant mutation disrupting eye morphology; the nonvital locus Aprt, structural gene for adenine phosphoribosyltransferase; Dras3, a homolog of the vertebrate ras oncogene; and 1(3)ecdysoneless (1(3)ecd), a gene that has been implicated in the regulation of larval molting hormone (ecdysteroid) synthesis. Overlapping chromosomal deletions of the region were generated by gamma-ray-induced reversion of the R mutation. Recessive lethal mutations were isolated based upon failure to complement the recessive lethality of Df(3L)RR2, a deletion of the DRE region that removes 16-18 polytene chromosome bands. A total of 117 mutations were isolated following ethyl methanesulfonate and gamma-ray mutagenesis. These and two additional define 13 lethal complementation groups. Mutations at two loci were recovered at ...
https://www.genetics.org/content/123/2/327
Pages that link to Hypoxanthine-guanine phosphoribosyltransferase - wikidocPages that link to Hypoxanthine-guanine phosphoribosyltransferase - wikidoc
The following pages link to Hypoxanthine-guanine phosphoribosyltransferase: View (previous 20 , next 20) (20 , 50 , 100 , 250 , 500) ...
https://www.wikidoc.org/index.php?title=Special:WhatLinksHere/Hypoxanthine-guanine_phosphoribosyltransferase&limit=20
A mycobacterial phosphoribosyltransferase promotes bacillary survival by inhibiting oxidative stress and autophagy pathways in...A mycobacterial phosphoribosyltransferase promotes bacillary survival by inhibiting oxidative stress and autophagy pathways in...
Mycobacterium tuberculosis (Mtb) employs various strategies to modulate host immune responses to facilitate its persistence in macrophages. The Mtb cell wall contains numerous glycoproteins with unknown role in pathogenesis. Here, by using concavalinA and LC-MS analysis we identified a novel mannosylated glycoprotein phosphoribosyl- transferase, encoded by the Rv3242c, from Mtb cell walls. Homology modeling, bioinformatic analyses and assay of phosphoribosyltransferase activity measurement in Mycobacterium smegmatis expressing recombinant Rv3242c (MsmRv3242c) confirmed the mass spectrometry data. Using Mycobacterium marinum-zebrafish and the surrogate MsmRv3242c infection models, we proved that phosphoribosyltransferase is involved in mycobacterial virulence. Histological and infection assays showed that M. marinum mimG mutant, an Rv3242c orthologue in a pathogenic M. marinum strain, was strongly attenuated in adult zebrafish and also survived less in macrophages. In contrast, infection with ...
https://portal.research.lu.se/portal/en/publications/a-mycobacterial-phosphoribosyltransferase-promotes-bacillary-survival-by-inhibiting-oxidative-stress-and-autophagy-pathways-in-macrophages-and-zebrafish
Imprinting of phosphoribosyltransferases during preimplantation development of the mouse mutant, Hprtb-m3 | DevelopmentImprinting of phosphoribosyltransferases during preimplantation development of the mouse mutant, Hprtb-m3 | Development
The measurement of the activity of the X-linked enzyme HPRT has been widely used as an indicator of X-chromosome activity during preimplantation development in the mouse. More recently, the concomitant measurement of the activity of the autosomally-encoded enzyme APRT has been used in an attempt to decrease the variability inherent in the measurement of enzyme activity from minute samples such as preimplantation embryos. In this study the use of the HPRT-deficient mouse mutant, Hprtb-m3, allowed the unequivocal identification of the parental origin of HPRT activity measured in embryos derived from crosses between wild-type mice, and mice which were homozygous or hemizygous for the Hprtb-m3 allele. Results were similar to those of a previous study, where oocyte-encoded HPRT activity accounted for about 10% of total HPRT activity at 76 hours post human chorionic gonadotrophin injection and the paternally-derived Hprt allele was shown to be transcriptionally active by the late 2-cell stage. In ...
https://dev.biologists.org/content/115/4/1011
Free Mecánica Estadística
well, this free aims a clear regulation of the lists submodel( accomplished below), summarized as the phosphoribosyltransferase file. meaningfully, the superior proportional free Mecánica revisited suggested yielding a superior Markov producer. 2 With a major free 4)-covariance event to the normal circularization of longitudinal mortality cells and a 1250 rings model is to produce the case of a using organism object; for joineRML, model to fragment.
http://www.scoutconnection.com/wwwboard/ebook.php?q=free-Meca%CC%81nica-estadi%CC%81stica/
Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency as the Unsuspected Cause of Renal Disease Spanning Three...Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency as the Unsuspected Cause of Renal Disease Spanning Three...
The favorable response to therapy, after the recognition of HPRT deficiency as the basis for the urolithiasis in 2 male siblings, contrasts sharply with the unfavorable outcome in their 2 uncles already in kidney failure. This underlines the importance of early diagnosis and therapy for the prognosis of partial HPRT deficiency. Lack of awareness of this disorder in many parts of mainland Europe is attributable to the fact that inherited defects of purine metabolism are relatively new diseases, the majority being discovered during the last 25 years. HPRT deficiency seems to be one of the most common enzyme defects of nucleotide metabolism among the 27 now described. This lack of awareness explains why it took so long for the diagnosis to be made in the uncles. Moreover, the elder, now 65, would have been 32 at the time the partial defect was first described by Kelly et al5 in 1967, when presumably renal function would already have been compromised. The development of renal disease in his nephew, ...
http://pediatrics.aappublications.org/content/109/1/e17
Disease InfoSearch - Partial hypoxanthine-guanine phosphoribosyltransferase deficiency - Definition, causes, resources and...
Are you looking for disease information or support? Simply type in the name of a disease or condition and Disease InfoSearch will locate quality information from a database of more than 13,000 diseases and thousands of support groups and foundations.
https://diseaseinfosearch.org/Partial+hypoxanthine-guanine+phosphoribosyltransferase+deficiency/9096
Rare Kidney Stone Consortium Biobank - Full Text View - ClinicalTrials.govRare Kidney Stone Consortium Biobank - Full Text View - ClinicalTrials.gov
Biologic samples will be stored in the biobank from well characterized patients with primary hyperoxaluria, cystinuria, APRT deficiency, and Dent disease, and from their family members, for use in future research. This will help to advance our understanding of disease expression and the factors associated with kidney injury in these four diseases with the overall goal of developing new treatments to preserve kidney function and reduce nephrocalcinosis and stone formation ...
https://clinicaltrials.gov/ct2/show/NCT02026388?cond=%22cystinuria%22&rank=2
X-chromosome activity in preimplantation mouse embryos from XX and XO mothersX-chromosome activity in preimplantation mouse embryos from XX and XO mothers
Embryos from XO female mice begin development with half the activity levels of an enzyme (HPRT) coded for by a gene on the X chromosome, compared with embryos from XX females. Groups of unfertilized eggs and individual embryos at the 8-cell, morula and blastocyst stages were assayed for HPRT activit …
https://pubmed.ncbi.nlm.nih.gov/568162/?dopt=Abstract
Edema & Jaundice & Sloping Shoulders: Causes & Reasons - SymptomaEdema & Jaundice & Sloping Shoulders: Causes & Reasons - Symptoma
Edema & Jaundice & Sloping Shoulders Symptom Checker: Possible causes include Orotate Phosphoribosyltransferase Deficiency. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
https://www.symptoma.com/en/ddx/edema+jaundice+sloping-shoulders
TIGR01091TIGR01091
A fairly deep split in phylogenetic and UPGMA trees separates this mostly prokaryotic set of uracil phosphoribosyltransferases from a mostly eukaryotic set that includes uracil phosphoribosyltransferase, uridine kinases, and other, uncharacterized proteins ...
http://www.jcvi.org/cgi-bin/tigrfams/HmmReportPage.cgi?acc=TIGR01091
Reactome | APRT [secretory granule lumen]Reactome | APRT [secretory granule lumen]
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
https://www.reactome.org/content/detail/R-HSA-6801079
Arkansas Natural Gas SummaryArkansas Natural Gas Summary
Notes: Prices are in nominal dollars. Through 2001, electric power price data are for regulated electric utilities only; beginning in 2002, data also include nonregulated members of the electric power sector. Monthly preliminary (from January 2018 to present) state-level data for the production series, except marketed production, are not available until after the final annual reports for this series is collected and processed. Final annual data are generally available in the third quarter of the following year. Gas volumes delivered for use as vehicle fuel are included in the State annual totals through 2010 but not in the State monthly components. Gas volumes delivered for vehicle fuel are included in the State monthly totals from January 2011 forward. See Definitions, Sources, and Notes link above for more information on this table ...
https://www.eia.gov/dnav/ng/ng_sum_lsum_dcu_SAR_a.htm
Molecular and biochemical studies on the hypoxanthine-guanine phosphoribosyltransferases of the pathogenic haemoflagellates<...Molecular and biochemical studies on the hypoxanthine-guanine phosphoribosyltransferases of the pathogenic haemoflagellates<...
TY - JOUR. T1 - Molecular and biochemical studies on the hypoxanthine-guanine phosphoribosyltransferases of the pathogenic haemoflagellates. AU - Ullman, Buddy. AU - Carter, Darrick. N1 - Funding Information: Acknowledgemenrs-This work was supported by grant A I-23682 from the National Institute of Allergy and Infectrouh Disease. Buddy Ullman is a Burroughs Wellcome Fund Scholar in Molecular Parasitology, and this work was SUP ported in part by grant from The Burroughs Wel!cnme Fund.. PY - 1997/2. Y1 - 1997/2. N2 - All genera of protozoan parasites are auxotrophic for purines, and thus, purine acquisition from the host is a nutritional necessity for the survival and growth of these pathogens. Many of these parasites, including Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp., access host purines by phosphoribosylating purine bases via purine phosphoribosyltransferase (PRT) enzymes. The trypanosomatid hypoxanthine-guanine phosphoribosyltransferase (HGPRT) enzyme has been implicated as a ...
https://ohsu.pure.elsevier.com/en/publications/molecular-and-biochemical-studies-on-the-hypoxanthine-guanine-pho-2
RCSB PDB - Obsolete - 5HHU: Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9...RCSB PDB - Obsolete - 5HHU: Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9...
Obsolete - 5HHU: Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase in complex with [3R,4R]-4-guanin-9-yl-3-((S)-2-hydroxy-2-phosphonoethyl)oxy-1-N-(phosphonopropionyl)pyrrolidine
https://www.rcsb.org/structure/removed/5HHU
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain superfamily
The SCOP classification for the Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain superfamily including the families contained in it. Additional information provided includes InterPro annotation (if available), Functional annotation, and SUPERFAMILY links to genome assignments, alignments, domain combinations, taxonomic visualisation and hidden Markov model information.
https://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47648
RCSB PDB - 2GEB: Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I...RCSB PDB - 2GEB: Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I...
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
https://www.rcsb.org/structure/2geb
Effect of regional DNA methylation on gene expression. - MySci...Effect of regional DNA methylation on gene expression. - MySci...
Effect of regional DNA methylation on gene expression.: The effect of DNA methylation on the transcriptional activity of the hamster adenine phosphoribosyltrans
https://www.mysciencework.com/publication/show/effect-of-regional-dna-methylation-on-gene-expression
QPRT (quinolinate phosphoribosyltransferase) - KOMP (Knockout Mouse Project)
The KOMP Repository is located at the University of California Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...
https://www.komp.org/geneinfo.php?project=CSD83980
What does HGPRT stand for?What does HGPRT stand for?
Looking for the definition of HGPRT? Find out what is the full meaning of HGPRT on Abbreviations.com! Hypoxanthin guanine phosphoribosyl tranferase is one option -- get in to view more @ The Webs largest and most authoritative acronyms and abbreviations resource.
http://www.abbreviations.com/HGPRT
Lesch-Nyhan syndrome | DermNet NZLesch-Nyhan syndrome | DermNet NZ
Lesch-Nyhan syndrome, Complete HGPRT deficiency, Choreoathetosis self mutilation syndrome, Total HGPRT deficiency, HGPRT deficiency, HPRT, Hypoxanthine-guanine phosphoribosyltransferase deficiency, Complete hypoxanthine-guanine phosphoribosyltransferase deficiency, Lesch Nyhan disease, Hypoxanthine guanine phosphoribosyltransferase deficiency, X linked hyperuricaemia, Juvenile gout, MIM 300322, Lesch-Nyan syndrome. Authoritative facts from DermNet New Zealand.
https://www.dermnetnz.org/topics/leschnyhan-syndrome
Lesch-Nyhan SyndromeLesch-Nyhan Syndrome
Lesch-Nyhan syndrome is caused by hyperuricemia (high serum levels of uric acid) due to a defective gene called the hypoxanthine guanine phosphoribosyltransferase. Patients with this syndrome are prone to have uric acid kidney stones and mental retardation. It is inherited as an X-linked recessive condition ...
http://healthboard.com/Encyclopedia/Biotech/term/lesch-nyhan_syndrome.html
HPRT1 Gene - GeneCards | HPRT Protein | HPRT AntibodyHPRT1 Gene - GeneCards | HPRT Protein | HPRT Antibody
Complete information for HPRT1 gene (Protein Coding), Hypoxanthine Phosphoribosyltransferase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=HPRT1&bioalma_cpd_art=all
HPRT1 Gene - GeneCards | HPRT Protein | HPRT AntibodyHPRT1 Gene - GeneCards | HPRT Protein | HPRT Antibody
Complete information for HPRT1 gene (Protein Coding), Hypoxanthine Phosphoribosyltransferase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=HPRT1&rf=/home/genecards/current/website/carddisp.pl&simap=2
Biochemical Correlates of Auto-Aggressive Behavior | SpringerLinkBiochemical Correlates of Auto-Aggressive Behavior | SpringerLink
The auto-aggressive behavior that characterizes the Lesch-Nyhan syndrome1 is unique among behavioral abnormalities in that the genetic and molecular basis of the disorder has been firmly established.2...
https://link.springer.com/chapter/10.1007/978-1-4613-0525-5_19
NIOSHTIC-2 Publications Search - 00111764 - Effect of acrylamide intoxication on pyridine nucleotide concentrations and...NIOSHTIC-2 Publications Search - 00111764 - Effect of acrylamide intoxication on pyridine nucleotide concentrations and...
The effect of acrylamide (79061) on pyridine nucleotide concentrations was studied in male Holtzman-rats. Animals were administered 40 milligrams per kilogram (mg/kg) per week of acrylamide and were sacrificed when the total cumulative dose was 428 or 668mg/kg. Rats given the lower cumulative dose developed mild symptoms of intoxication characterized by decreased body tone and increased excitabili
https://www.cdc.gov/niosh/nioshtic-2/00111764.html
Adenine phosphoribosyltransferaseAdenine phosphoribosyltransferase
"Adenine phosphoribosyltransferase isoforms of Arabidopsis and their potential contributions to adenine and cytokinin metabolism ... Adenine phosphoribosyltransferase (APRTase) is an enzyme encoded by the APRT gene, found in humans on chromosome 16. It is part ... Adenine+phosphoribosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH) Human APRT genome ... Takeuchi H, Kaneko Y, Fujita J, Yoshida O (Apr 1993). "A case of a compound heterozygote for adenine phosphoribosyltransferase ...
https://en.wikipedia.org/wiki/Adenine_phosphoribosyltransferase
Adenine phosphoribosyltransferase deficiencyAdenine phosphoribosyltransferase deficiency
... is an autosomal recessive metabolic disorder associated with a mutation in the ... Adenine phosphoribosyltransferase deficiency at NIH's Office of Rare Diseases (Articles with short description, Short ... Patients with the disease deficiency lack the enzyme adenine phosphoribosyltransferase and therefore have difficulties breaking ... "Adenine phosphoribosyltransferase(APRT) deficiency" (Free full text). Nippon Rinsho. Japanese Journal of Clinical Medicine. 54 ...
https://en.wikipedia.org/wiki/Adenine_phosphoribosyltransferase_deficiency
AllopurinolAllopurinol
... adenine phosphoribosyltransferase. It is also used to treat kidney stones caused by deficient activity of adenine ... hypoxanthine-guanine phosphoribosyltransferase, including Lesch-Nyhan syndrome; glucose 6-phosphatase including glycogen ... phosphoribosyltransferase. Allopurinol was also commonly used to treat tumor lysis syndrome in chemotherapeutic treatments, as ...
https://en.wikipedia.org/wiki/Allopurinol
Kidney stone diseaseKidney stone disease
People affected by adenine phosphoribosyltransferase deficiency may produce 2,8-dihydroxyadenine stones, alkaptonurics produce ... Kamatani N (December 1996). "[Adenine phosphoribosyltransferase(APRT) deficiency]". Nihon Rinsho. Japanese Journal of Clinical ...
https://en.wikipedia.org/wiki/Kidney_stone_disease
Purine metabolismPurine metabolism
The enzyme adenine phosphoribosyltransferase (APRT) salvages adenine. The enzyme hypoxanthine-guanine phosphoribosyltransferase ... Both adenine and guanine are derived from the nucleotide inosine monophosphate (IMP), which is the first compound in the ... Hyperuricemia and Lesch-Nyhan syndrome by the loss of hypoxanthine-guanine phosphoribosyltransferase. Different types of cancer ...
https://en.wikipedia.org/wiki/Purine_metabolism
Nucleic acid metabolismNucleic acid metabolism
For example, adenine + PRPP --> AMP + PPi. This reaction requires the enzyme adenine phosphoribosyltransferase. Free guanine is ... Adenine and guanine are the two nucleotides classified as purines. In purine synthesis, PRPP is turned into inosine ... Lesch-Nyhan syndrome is caused by a deficiency in hypoxanthine-guanine phosphoribosyltransferase or HGPRT, the enzyme that ... salvaged in the same way except it requires hypoxanthine-guanine phosphoribosyltransferase. Defects in purine catabolism can ...
https://en.wikipedia.org/wiki/Nucleic_acid_metabolism
2-Fluoroadenine2-Fluoroadenine
Schaff, Dennis A. (1994). "The adenine phosphoribosyltransferase (APRT) selectable marker system". Plant Science. Elsevier BV. ... adenine phosphoribosyltransferase) genes. Therefore, knockouts or mutants for APT, which are resistant to 2-FA, can be selected ... "Mutants of Saccharomyces cerevisiae deficient in adenine phosphoribosyltransferase". Mutation Research/Fundamental and ... 2-Fluoroadenine (2-FA) is a toxic adenine antimetabolite which can be used in laboratory biological research for ...
https://en.wikipedia.org/wiki/2-Fluoroadenine
Richard AxelRichard Axel
"DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells". Proceedings of the National Academy ...
https://en.wikipedia.org/wiki/Richard_Axel
Anton YuryevAnton Yuryev
A Saccharomyces cerevisiae gene encoding a potential adenine phosphoribosyltransferase Yuryev A, and Corden JL. Yeast 1994;10 ( ...
https://en.wikipedia.org/wiki/Anton_Yuryev
Phosphoribosyl pyrophosphatePhosphoribosyl pyrophosphate
"Structural Complexes of Human Adenine Phosphoribosyltransferase Reveal Novel Features of the APRT Catalytic Mechanism". Journal ... Decreased levels of hypoxanthine guanine phosphoribosyl transferase (HGPRT) causes this accumulation, as PRPP is a substrate ... Salmonella typhimurium nicotinate phosphoribosyltransferase". Journal of Biological Chemistry. 268 (34): 26004-26010. doi: ... with the first step being N-alkylation of anthranilic acid catalysed by the enzyme anthranilate phosphoribosyltransferase. ...
https://en.wikipedia.org/wiki/Phosphoribosyl_pyrophosphate
Nucleotide salvageNucleotide salvage
There are two types of phosphoribosyltransferases: adenine phosphoribosyltransferase (APRT) and hypoxanthine-guanine ... Phosphoribosyltransferases add activated ribose-5-phosphate (Phosphoribosyl pyrophosphate, PRPP) to bases, creating nucleoside ... Hypoxanthine is acted upon by HGXPRT(hypoxanthine guanine xanthine phosphoribosyl transferase) in the parasite to convert the ... Nicotinate salvage is the process of regenerating nicotinamide adenine dinucleotide from nicotinic acid. This pathway is ...
https://en.wikipedia.org/wiki/Nucleotide_salvage
2,8-Dihydroxyadenine2,8-Dihydroxyadenine
... is excreted in the urine because of a deficiency in the adenine salvage enzyme adenine phosphoribosyltransferase. The defect is ... 2,8-Dihydroxyadenine is a derivative of adenine which accumulates in 2,8 dihydroxy-adenine urolithiasis. The poorly soluble ... "Identification of two novel mutations in adenine phosphoribosyltransferase gene in patients with 2,8-dihydroxyadenine ...
https://en.wikipedia.org/wiki/2,8-Dihydroxyadenine
2,6-Diaminopurine2,6-Diaminopurine
Cancer cells are known to become resistant to DAP by losing their adenine phosphoribosyltransferase (APRT) function, a process ... 6-diaminopurine and 6-methylpurine that affect adenine phosphoribosyltransferase in Escherichia coli K-12]". Genetika. 13 (10 ... As the Z base, it is found instead of adenine (A) in the genetic material of some bacteriophage viruses. In August 2011, a ... 2-aminoadenine is an adenine substituting for a base in S-2L cyanophage DNA. Nature. 1977 Nov 24;270(5635):369-70. Jacinta ...
https://en.wikipedia.org/wiki/2,6-Diaminopurine
PentosyltransferasePentosyltransferase
Examples include: adenine phosphoribosyltransferase hypoxanthine-guanine phosphoribosyltransferase pertussis toxin poly ADP ...
https://en.wikipedia.org/wiki/Pentosyltransferase
GlycosomeGlycosome
These enzymes found in the glycosome to help with synthesis are guanine and adenine phosphoribosyl transferase, hypoxanthine, ...
https://en.wikipedia.org/wiki/Glycosome
PhosphoribosyltransferasePhosphoribosyltransferase
Adenine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase Orotate phosphoribosyltransferase Quinolinate ... A phosphoribosyltransferase is a type of transferase enzyme. Types include: ... phosphoribosyltransferase Uracil phosphoribosyltransferase v t e (Transferases, All stub articles, Enzyme stubs). ...
https://en.wikipedia.org/wiki/Phosphoribosyltransferase
TransphosphoribosidaseTransphosphoribosidase
... may refer to: Adenine phosphoribosyltransferase, an enzyme Hypoxanthine phosphoribosyltransferase This ...
https://en.wikipedia.org/wiki/Transphosphoribosidase
APRTAPRT
... may refer to: Adenine phosphoribosyltransferase, an enzyme Adenine phosphoribosyltransferase deficiency, a genetic and ...
https://en.wikipedia.org/wiki/APRT
Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferaseNicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase
... adenine) phosphoribosyltransferase, nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase, and nicotinate ... In enzymology, a nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) is an enzyme that ... Other names in common use include CobT, nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase, nicotinate ... 6-dimethylbenzimidazole phosphoribosyltransferase responsible for the synthesis of N1-(5-phospho-alpha-D-ribosyl)-5,6- ...
https://en.wikipedia.org/wiki/Nicotinate-nucleotide—dimethylbenzimidazole_phosphoribosyltransferase
List of EC numbers (EC 2)List of EC numbers (EC 2)
... adenine phosphoribosyltransferase EC 2.4.2.8: hypoxanthine phosphoribosyltransferase EC 2.4.2.9: uracil ... orotate phosphoribosyltransferase EC 2.4.2.11: now EC 6.3.4.21 nicotinate phosphoribosyltransferase EC 2.4.2.12: nicotinamide ... ATP phosphoribosyltransferase EC 2.4.2.18: anthranilate phosphoribosyltransferase EC 2.4.2.19: nicotinate-nucleotide ... nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase EC 2.4.2.22: xanthine phosphoribosyltransferase EC 2.4. ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_2)
List of MeSH codes (D08)List of MeSH codes (D08)
... adenine phosphoribosyltransferase MeSH D08.811.913.400.725.115 - adp ribose transferases MeSH D08.811.913.400.725.115.180 - ... anthranilate phosphoribosyltransferase MeSH D08.811.913.400.725.200 - ATP phosphoribosyltransferase MeSH D08.811.913.400. ... 725.450 - hypoxanthine phosphoribosyltransferase MeSH D08.811.913.400.725.700 - orotate phosphoribosyltransferase MeSH D08.811. ... flavin-adenine dinucleotide MeSH D08.211.474.650.500 - flavin mononucleotide MeSH D08.211.790.249 - g(m2) activator protein ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
List of diseases (A)List of diseases (A)
... thumb club foot syndrome Adducted thumb syndrome recessive form Adducted thumbs Dundar type Adenine phosphoribosyltransferase ...
https://en.wikipedia.org/wiki/List_of_diseases_(A)
Xanthine phosphoribosyltransferaseXanthine phosphoribosyltransferase
Their relationship to hypoxanthine and adenine phosphoribosyltransfer activities". J. Biol. Chem. 245 (10): 2605-11. PMID ... In enzymology, a xanthine phosphoribosyltransferase (EC 2.4.2.22) is an enzyme that catalyzes the chemical reaction XMP + ... Other names in common use include Xan phosphoribosyltransferase, xanthosine 5'-phosphate pyrophosphorylase, xanthylate ...
https://en.wikipedia.org/wiki/Xanthine_phosphoribosyltransferase
MetaproteomicsMetaproteomics
... adenine phosphoribosyltransferases, and guanine phosphoribosyltransferases. The human subjects experienced increases in ...
https://en.wikipedia.org/wiki/Metaproteomics
Nicotinamide phosphoribosyltransferaseNicotinamide phosphoribosyltransferase
The intracellular form of this protein (iNAMPT) is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD+) ... Nicotinamide phosphoribosyltransferase (NAmPRTase or NAMPT), formerly known as pre-B-cell colony-enhancing factor 1 (PBEF1) or ... Revollo JR, Grimm AA, Imai S (March 2007). "The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/ ... Grolla AA, Travelli C, Genazzani AA, Sethi JK (July 2016). "Extracellular nicotinamide phosphoribosyltransferase, a new cancer ...
https://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase
Nicotinamide adenine dinucleotideNicotinamide adenine dinucleotide
The first step, and the rate-limiting enzyme in the salvage pathway is nicotinamide phosphoribosyltransferase (NAMPT), which ... Nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism. Found in all living cells, NAD is called a ... Nicotinamide adenine dinucleotide has several essential roles in metabolism. It acts as a coenzyme in redox reactions, as a ... "Nicotinamide-Adenine-Dinucleotide". pubchem.ncbi.nlm.nih.gov. The nicotinamide group can be attached in two orientations to the ...
https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide
HypoxanthineHypoxanthine
... also known as alkyl adenine glycosylase (Aag). Adenine Guanine Xanthine "Estimation of Plasmodium falciparum drug ... Hypoxanthine-guanine phosphoribosyltransferase converts hypoxanthine into IMP in nucleotide salvage. Hypoxanthine is also a ... Because of its resemblance to guanine, the spontaneous deamination of adenine can lead to an error in DNA transcription/ ... including the DNA and RNA components adenine and guanine, may have been formed extraterrestrially in outer space. The Pheretima ...
https://en.wikipedia.org/wiki/Hypoxanthine
Joseph TakahashiJoseph Takahashi
In 2009, Joseph Bass in collaboration with Takahashi's group discovered that nicotinamide phosphoribosyltransferase (NAMPT) ... mediated synthesis of metabolic coenzyme nicotinamide adenine dinucleotide (NAD+), which both oscillate on a daily cycle, may ...
https://en.wikipedia.org/wiki/Joseph_Takahashi
MIR34AMIR34A
miR-34a suppresses the gene expression of the NAMPT gene which encodes the nicotinamide phosphoribosyltransferase (Nampt) ... enzyme which is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD) salvage pathway, resulting in reduced ...
https://en.wikipedia.org/wiki/MIR34A
P7C3P7C3
The mechanism of action of the P7C3 series of compounds involves activation of nicotinamide phosphoribosyltransferase (NAMPT), ... the rate-limiting enzyme responsible for the transformation of nicotinamide into nicotinamide adenine dinucleotide (NAD). By ...
https://en.wikipedia.org/wiki/P7C3
NucleotideNucleotide
The purine bases adenine and guanine and pyrimidine base cytosine occur in both DNA and RNA, while the pyrimidine bases thymine ... Orotate phosphoribosyltransferase (PRPP transferase) catalyzes the net reaction yielding orotidine monophosphate (OMP): Orotate ... Adenine forms a base pair with thymine with two hydrogen bonds, while guanine pairs with cytosine with three hydrogen bonds. In ... The four nucleobases in DNA are guanine, adenine, cytosine and thymine; in RNA, uracil is used in place of thymine. Nucleotides ...
https://en.wikipedia.org/wiki/Nucleotide
UracilUracil
The others are adenine (A), cytosine (C), and guanine (G). In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the ... Uracil also recycles itself to form nucleotides by undergoing a series of phosphoribosyltransferase reactions. Degradation of ... Uracil pairs with adenine through hydrogen bonding. When base pairing with adenine, uracil acts as both a hydrogen bond ... In RNA, uracil base-pairs with adenine and replaces thymine during DNA transcription. Methylation of uracil produces thymine. ...
https://en.wikipedia.org/wiki/Uracil
Lesch-Nyhan syndromeLesch-Nyhan syndrome
The purine bases (adenine and guanine) and pyrimidine bases (thymine and cytosine) are bound to deoxyribose and phosphate and ... In Lesch-Nyhan syndrome, the defective gene is that for hypoxanthine-guanine phosphoribosyltransferase (HGPRT), a participant ... so named because it codes for the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT or HGPRT, EC 2.4.2.8). This ... is a rare inherited disorder caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT). This ...
https://en.wikipedia.org/wiki/Lesch–Nyhan_syndrome
Purine riboswitchPurine riboswitch
The add adenine riboswitch has shown three distinct stable conformations in the presence of adenine. When unbound to adenine, ... The xpt gene encodes a specific xanthine phosphoribosyltransferase protein, which is involved in purine metabolism. Unlike the ... The Adenine Riboswitch selectively recognizes adenine, and contains a uracil ribonucleotide in position 74 of the adenine- ... In this way, an abundance of adenine can instigate the process of adenine's efflux from a cell. Unlike the add adenine ...
https://en.wikipedia.org/wiki/Purine_riboswitch
Adenine phosphoribosyltransferase deficiency: MedlinePlus GeneticsAdenine phosphoribosyltransferase deficiency: MedlinePlus Genetics
Adenine phosphoribosyltransferase (APRT) deficiency is an inherited condition that affects the kidneys and urinary tract. ... medlineplus.gov/genetics/condition/adenine-phosphoribosyltransferase-deficiency/ Adenine phosphoribosyltransferase deficiency. ... Adenine phosphoribosyltransferase (APRT) deficiency is an inherited condition that affects the kidneys and urinary tract. The ... Adenine phosphoribosyltransferase deficiency in children. Pediatr Nephrol. 2012 Apr;27(4):571-9. doi: 10.1007/s00467-011-2037-0 ...
https://medlineplus.gov/genetics/condition/adenine-phosphoribosyltransferase-deficiency/
Human Adenine Phosphoribosyltransferase (APRT) Protein (Myc-DYKDDDDK Tag), Recombinant | ABIN2714849Human Adenine Phosphoribosyltransferase (APRT) Protein (Myc-DYKDDDDK Tag), Recombinant | ABIN2714849
Recombinant Adenine Phosphoribosyltransferase (APRT) Protein (Myc-DYKDDDDK Tag). Spezies: Human. Quelle: HEK-293 Cells. Jetzt ... Tb07.43M14.200, Tb07.43M14.180, C85684, AMP, APRTD, adenine phosphoribosyltransferase, adenine phosphoribosyl transferase, ... Adenine Phosphoribosyltransferase (APRT) (AA 2-180) protein (His tag) APRT Spezies: Ratte Wirt: Hefe Recombinant > 90 % ELISA ... Adenine Phosphoribosyltransferase (APRT) (AA 2-180) protein (His tag) APRT Spezies: Rind (Kuh) Wirt: Hefe Recombinant > 90 % ...
https://www.antikoerper-online.de/protein/2714849/Adenine+Phosphoribosyltransferase+APRT+Transcript+Variant+1+protein+Myc-DYKDDDDK+Tag/
Mutations affecting adenine phosphoribosyl transferase activity in Chinese hamster cells. - WikidataMutations affecting adenine phosphoribosyl transferase activity in Chinese hamster cells. - Wikidata
Mutations affecting adenine phosphoribosyl transferase activity in Chinese hamster cells.. scientific article ...
https://m.wikidata.org/wiki/Q54638670
Search Ageing-Associated Genes in Model OrganismsSearch Ageing-Associated Genes in Model Organisms
Adenine PhosphoribosylTransferase. Saccharomyces cerevisiae. Anti-Longevity APT1. 855660. AQR1. Aqr1p. Saccharomyces cerevisiae ... ADEnine requiring. Saccharomyces cerevisiae. Anti-Longevity ADE4. 852617. ADE5,7. ADEnine requiring. Saccharomyces cerevisiae. ... ADEnine requiring. Saccharomyces cerevisiae. Anti-Longevity ADE1. 855501. ADE12. ADEnine requiring. Saccharomyces cerevisiae. ... ADEnine requiring. Saccharomyces cerevisiae. Anti-Longevity ADE2. 853118. ADE3. ADEnine requiring. Saccharomyces cerevisiae. ...
https://genomics.senescence.info/genes/search.php?organism=Saccharomyces+cerevisiae&show=4
Sol Genomics Network
Symbols: APT4 , APT4; adenine phosphoribosyltransferase , chr4:7376265-7380117 FORWARD. swissprot. blastx. No significant hits ...
https://www.sgn.cornell.edu/search/unigene.pl?unigene_id=SGN-U326310
Prospective Research Rare Kidney Stones - Mayo ClinicProspective Research Rare Kidney Stones - Mayo Clinic
Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator ...
https://www.mayo.edu/research/clinical-trials/cls-20358447?p=1
Diseases Browser
ADENINE PHOSPHORIBOSYLTRANSFERASE; APRT 2,[email protected] UROLITHIASIS, INCLUDED. 102600. 11. ADENOCARCINOMA OF THE ...
https://www.coriell.org/0/Sections/BrowseCatalog/Diseases.aspx?PgId=3
Human Metabolome Database: Showing metabocard for Potassium (HMDB0000586)Human Metabolome Database: Showing metabocard for Potassium (HMDB0000586)
Adenine Phosphoribosyltransferase Deficiency (APRT) (PathBank: SMP0000535). *Mitochondrial DNA Depletion Syndrome (PathBank: ...
https://hmdb.ca/metabolites/HMDB0000586
US Patent for Alteration of Fc-fusion protein serum half-lives by mutagenesis Patent (Patent # 7,217,798 issued May 15, 2007) ...US Patent for Alteration of Fc-fusion protein serum half-lives by mutagenesis Patent (Patent # 7,217,798 issued May 15, 2007) ...
USA 48:2026 (1962)), and adenine phosphoribosyltransferase (Lowy et al., Cell 22:817 (1980)) genes can be employed in tk-, ... The TNF-RII/Fc-fusion gene is followed by a gene encoding xanthine guanine phosphoribosyl transferase (gpt), together with ... hypoxanthine-guanine phosphoribosyltransferase (Szybalska & Szybalski, Proc. Natl. Acad. Sci. ...
https://patents.justia.com/patent/7217798
Integration of transcriptomic and proteomic analyses reveals several levels of metabolic regulation in the excess starch and...Integration of transcriptomic and proteomic analyses reveals several levels of metabolic regulation in the excess starch and...
In this study, APRT (adenine phosphoribosyltransferase form 2) in lses1 showed a higher protein abundance level than that in WT ... Cloning a second form of adenine phosphoribosyl transferase gene (TaAPT2) from wheat and analysis of its association with ... and adenine phosphoribosyltransferase form 2 (APRT) involved in nucleic acid metabolism were regulated at both mRNA and protein ... adenine phosphoribosyltransferase form 2; KPR6: cyclin-dependent kinase inhibitor 6; TET6: tetraspanin-6; ASR5: abscisic stress ...
https://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-022-03510-2
HOMD :: SEQF1139HOMD :: SEQF1139
Adenine phosphoribosyltransferase. 124. SEQF1139,ABDN02000061.1. SEQF1139_00126 jb [NA] [AA] 204/67. 126289-126086. ...
https://www.homd.org/genome/explorer?gid=SEQF1139&anno=prokka
HOMD :: SEQF2779HOMD :: SEQF2779
adenine phosphoribosyltransferase. 12. SEQF2779,CP000925.1. ABY79240.1 jb [NA] [AA] 375/124. 236421-236795. ribosomal protein ... adenine-specific DNA modification methylase. 147. SEQF2779,CP000925.1. ABY79375.1 jb [NA] [AA] 771/256. 306995-307765. ... nicotinate phosphoribosyltransferase (NAPRTase) family. 89. SEQF2779,CP000925.1. ABY79317.1 jb [NA] [AA] 1287/428. 303015- ...
https://homd.org/genome/explorer?gid=SEQF2779&anno=ncbi
Catalog Navigator : Microbiology and Molecular Genetics 681 Catalog Navigator : Microbiology and Molecular Genetics 681
Adenine phosphoribosyltransferase deficiency; chronic renal failure; microchimerism and organ transplantation; Alzheimers ...
https://catalogs.rutgers.edu/generated/nb-grad_1012/pg314.html
METHODS OF REDUCING LACTATE IN LIVER DISEASE PATIENTS USING VARIANTS AND FUSIONS OF FGF19/FGF21 POLYPEPTIDES - NGM...METHODS OF REDUCING LACTATE IN LIVER DISEASE PATIENTS USING VARIANTS AND FUSIONS OF FGF19/FGF21 POLYPEPTIDES - NGM...
USA 48:2026 (1962)), and adenine phosphoribosyltransferase (Lowy et al, Cell 22:817 (1980)) genes that can be employed in tk-, ... hypoxanthine-guanine phosphoribosyltransferase gene (Szybalska etal, Proc. Natl. Acad. Sci. ...
https://www.sumobrain.com/patents/wipo/Methods-reducing-lactate-in-liver/WO2021092140A1.html
CoP: Co-expressed Biological Processes
Adenine phosphoribosyltransferase 5). F:adenine phosphoribosyltransferase activity;P:nucleoside metabolic process, adenine ...
http://webs2.kazusa.or.jp/kagiana/cgi-bin/xp2g.cgi?gsm=GSM133930&organism=ath
American Society of Nephrology | Kidney Week - Abstract Details (2022)American Society of Nephrology | Kidney Week - Abstract Details (2022)
... patients with previously undiagnosed Adenine Phosphoribosyltransferase (APRT) Deficiency, for whom treatment with xanthine ...
https://www.asn-online.org/education/kidneyweek/2022/program-abstract.aspx?controlId=3766370
nephrotic syndrome type 19 - Ontology Browser - Rat Genome Database
adenine phosphoribosyltransferase deficiency adult spinal muscular atrophy agammaglobulinemia 1 agammaglobulinemia 2 ...
https://rgd.mcw.edu/rgdweb/ontology/view.html?acc_id=DOID:0080394
DeCSDeCS
Adenine Phosphoribosyltransferase Entry term(s). AMP Pyrophosphorylase APRTase Phosphoribosyltransferase, Adenine ... Adenine phosphoribosyltransferase Entry term(s):. AMP Pyrophosphorylase. APRTase. Phosphoribosyltransferase, Adenine. ... Adenine Phosphoribosyltransferase - Preferred Concept UI. M0000353. Scope note. An enzyme catalyzing the formation of AMP from ... An enzyme catalyzing the formation of AMP from adenine and phosphoribosylpyrophosphate. It can act as a salvage enzyme for ...
https://decs.bvsalud.org/en/ths/resource/?id=236
Code System Concept
Adenine phosphoribosyltransferase (substance). Code System Preferred Concept Name. Adenine phosphoribosyltransferase (substance ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=83334005
Steven C. Almo - Publications - Albert Einstein College of MedicineSteven C. Almo - Publications - Albert Einstein College of Medicine
Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae. Shi, W., Tanaka, K. S. E., Crother, T. ... Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration. Shi, W ...
https://einstein.pure.elsevier.com/en/persons/steven-c-almo/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=publicationYearThenTitle&descending=false&page=1
OBM Geriatrics | Perspectives to Modify and Counter Aging in the Frame of Subtelomere-Telomere Theory of AgingOBM Geriatrics | Perspectives to Modify and Counter Aging in the Frame of Subtelomere-Telomere Theory of Aging
Stein R, Razin A, Cedar H. In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression ...
https://lidsen.com/journals/geriatrics/geriatrics-06-04-208
Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome | Orphanet Journal of Rare Diseases |...Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome | Orphanet Journal of Rare Diseases |...
Deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity is an inborn error of purine metabolism associated ... with increased adenine phosphoribosyltransferase (APRT) activity. Lesch-Nyhan patients (grade 4) present undetectable HPRT ... Phosphoribosyltransferase (PRT) deficiency in X-linked cerebral palsy and in a variant of gout. J Pediatr. 1968, 73: 583-592. ... Puig JG, Torres RJ, Mateos FA, Ramos T, Buno AS, Arcas J: The spectrum of hypoxanthine-guanine phosphoribosyltransferase (HPRT ...
https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-2-48
Coffea arabica L. - ICG
Adenine phosphoribosyltransferase *drought stress. GR996015 *F: actctccggggctaaaactgtc. *R:aggtcgtgctggttgagttagg. NA 60 SYBR ...
http://icg.big.ac.cn/index.php?title=Coffea_arabica_L.&oldid=791
Network Portal - Gene CAC0083
Adenine phosphoribosyltransferase; Apt (NCBI ptt file). 152, 276. CAC2295. CAC2295. Uncharacterized conserved protein, YebC ...
http://networks.systemsbiology.net/cac/gene/CAC0083
Allopurinol Hexal : Uses, Side Effects, Interactions, Dosage / PillintripAllopurinol Hexal : Uses, Side Effects, Interactions, Dosage / Pillintrip
... adenine phosphoribosyltransferase.. Allopurinol Hexal is indicated for the management of 2,8-dihydroxyadenine (2,8-DHA) renal ... adenine phosphoribosyltransferase. Allopurinol Hexal is indicated for the management of 2,8-dihydroxyadenine (2,8-DHA) renal ... stones related to deficient activity of adenine phosphoribosyltransferase.. Allopurinol Hexal is indicated for the management ... stones related to deficient activity of adenine phosphoribosyltransferase.. Allopurinol Hexal is indicated for the management ...
https://pillintrip.com/medicine/allopurinol-hexal
protein deficiencyprotein deficiency
Adenine Phosphoribosyltransferase. 1. + 77. Carboxy-Lyases. 1. + 78. Factor XI. 1. + 79. Pteridines. 1. + ...
https://lookfordiagnosis.com/results.php?symptoms=protein+deficiency&lang=1&parent=%2F&mode=F&therapy_ap=1
STEPdb: Sub-cellular Topologies of E.coli Polypeptides.
mouse over and click on the one letter topology symbols to see which proteins of this specific subproteome are localized in each location). ...
http://versionone.stepdb.eu/complexesk12list.php?start=77
List of EC numbers (EC 2)List of EC numbers (EC 2)
adenine phosphoribosyltransferase. *: hypoxanthine phosphoribosyltransferase. *: uracil phosphoribosyltransferase. *: orotate ... nicotinate phosphoribosyltransferase. *: nicotinamide phosphoribosyltransferase. *: now EC 2.5.1.6. *: ... rRNA (adenine-N6-)-methyltransferase. *: amine N-methyltransferase. *: loganate O-methyltransferase. *: rRNA (guanine-N1-)- ... tRNA (adenine-N1-)-methyltransferase. *: DNA (cytosine-5-)-methyltransferase. *: O-demethylpuromycin O-methyltransferase. *: ...
https://en-academic.com/dic.nsf/enwiki/2736422
MEPACO - MEPACOMEPACO - MEPACO
... adenine phosphoribosyltransferase.. Uric Pure is indicated for the management of 2,8-dihydroxyadenine (2,8-DHA) renal stones ... related to deficient activity of adenine phosphoribosyltransferase.. Uric Pure is indicated for the management of recurrent ... hypoxanthine-guanine phosphoribosyltransferase, including Lesch-Nyhan syndrome; glucose-6-phosphatase including glycogen ...
http://mepaco-pharma.net/en/component/content/article/99-by-category/analgesics-and-antirheumatics/254-uric-pure-100-mg.html?Itemid=978
APRTHypoxanthine-guanine phosphoribosyltraPhosphoribosyl transferaseDeficiencyEnsemblXanthine oxidasePhosphoribosylpyrophosphateAdenosineEnzymeAmineGuanineInterproscanPurineSalvagePurinesMoleculeActivityIncludeNAMPTDeficiencyEnzymesDinucleotidePathwayNucleotide translocatorPhosphateMitochondriaUracilEnzyme calledGeneNicotinateCytosineCellsRenalFunctionalForm
APRT6
  • Adenine phosphoribosyltransferase (APRT) deficiency is an inherited condition that affects the kidneys and urinary tract. (medlineplus.gov)
  • This gene provides instructions for making APRT, an enzyme that helps to convert a DNA building block (nucleotide) called adenine to a molecule called adenosine monophosphate (AMP). (medlineplus.gov)
  • Significant alterations to treatment were indicated for 2 (unrelated) patients with previously undiagnosed Adenine Phosphoribosyltransferase (APRT) Deficiency, for whom treatment with xanthine oxidase inhibitor was initiated to reduce risk of graft damage and loss. (asn-online.org)
  • Adenine phosphoribosyl transferase (APRT) deficiency is a rare genetic condition that often presents with recurrent dihydroxyadenine (DHA) urolithiasis. (wjnu.org)
  • Formation of 2,8-dihydroxyadenine (DHA) stones is a rare form of urolithiasis that occurs in patients with adenine phosphoribosyl transferase (APRT) deficiency. (wjnu.org)
  • The 2,8-DHA is the end product of adenine metabolism by xanthine oxidase in the absence of APRT ( Fig. 2 ). (wjnu.org)
Hypoxanthine-guanine phosphoribosyltra2
  • Deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity is an inborn error of purine metabolism associated with uric acid overproduction and a continuum spectrum of neurological manifestations depending on the degree of the enzymatic deficiency. (biomedcentral.com)
  • Group 1: The patient may have deficiencies in hypoxanthine-guanine phosphoribosyltransferase (HGPRT), adenine phosphoribosyltransferase, or xanthine dehydrogenase enzymes. (medscape.com)
Phosphoribosyl transferase1
  • Mutations affecting adenine phosphoribosyl transferase activity in Chinese hamster cells. (wikidata.org)
Deficiency3
  • Edvardsson VO, Sahota A, Palsson R. Adenine Phosphoribosyltransferase Deficiency. (medlineplus.gov)
  • The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). (mayo.edu)
  • In adenosine deaminase deficiency, adenosine and adenine accumulate in the plasma. (medscape.com)
Ensembl1
  • xanthine-guanine phosphoribosyltransferase [Ensembl]. (ntu.edu.sg)
Xanthine oxidase1
  • Degradation of adenine occurs in several steps, first enzyme purine nucleoside phosphorylase converts adenosine into inosine which in the presence of enzyme xanthine oxidase is converted to hypoxanthine that is finally metabolised into uric acid. (biologybard.com)
Phosphoribosylpyrophosphate1
  • An enzyme catalyzing the formation of AMP from adenine and phosphoribosylpyrophosphate. (bvsalud.org)
Adenosine1
  • The nucleosides of adenine include deoxyadenosine and adenosine. (biologybard.com)
Enzyme4
  • A lack of functional enzyme impairs the conversion of adenine to AMP. (medlineplus.gov)
  • It can act as a salvage enzyme for recycling of adenine into nucleic acids. (bvsalud.org)
  • Enzyme adenine phosphoribosyltransferase aids in the salvaging of adenine formed and in its re-utilisation. (biologybard.com)
  • A series of tests pointed to a specific enzyme called adipokine nicotinamide phosphoribosyltransferase, (NAMPT), which is known to be involved in some of the pathological metabolic problems caused by obesity. (eurekalert.org)
Amine1
  • Adenine has an amine group at the 6th position and an additional double bond between C-6 and N-1 in its pyrimidine ring. (biologybard.com)
Guanine4
  • Guanine and Adenine both are purine nucleobases but differ in their structure. (biologybard.com)
  • Guanine pairs with cytosine with 3 hydrogen bonds while adenine pairs with thymine in DNA and in RNA it pairs complementary to Uracil with two hydrogen bonds. (biologybard.com)
  • The level of 1-HP-adenine corresponded to 2% of 7-HP-guanine. (who.int)
  • 1-HP-adenine is chemically more stable ( t 1/2 = 9.2 days for rearrangement to an N 6 adduct compared with t 1/2 = 5 days for depurination of 7-HP-guanine). (who.int)
Interproscan2
  • Nicotinate phosphoribosyltransferase (NAPRTase) family, Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain [Interproscan]. (ntu.edu.sg)
  • Ribosomal RNA adenine dimethylase [Interproscan]. (ntu.edu.sg)
Purine1
  • Adenine is an organic purine nitrogenous base having the formula C 5 H 5 N 5 that complementarily pairs with thymine and uracil in RNA and DNA respectively. (biologybard.com)
Salvage1
  • Modulation of adenine phosphoribosyltransferase‐mediated salvage pathway to accelerate diabetic wound healing. (visualprotein.com)
Purines1
  • Adenine like other purines is an aromatic heterocyclic compound. (biologybard.com)
Molecule2
  • As a result, adenine is converted to another molecule called 2,8-dihydroxyadenine (2,8-DHA). (medlineplus.gov)
  • In the body, NAMPT exists in two forms: an intracellular form, which regulates the production of nicotinamide adenine dinucleotide (NAD+), an important molecule for the generation of energy in the cell. (eurekalert.org)
Activity1
  • Allopurinol Hexal is indicated for the management of 2,8-dihydroxyadenine (2,8-DHA) renal stones related to deficient activity of adenine phosphoribosyltransferase. (pillintrip.com)
Include1
  • Other compounds that comprise Adenine include co-factors like FAD and NAD. (biologybard.com)
NAMPT14
  • 5. Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair. (nih.gov)
  • We demonstrate that nicotinamide phosphoribosyltransferase (Nampt), the equivalent enzyme in nicotinamide recycling to NAD + in vertebrates,can functionally substitute for PNC-1. (biologists.com)
  • OBJECTIVE: The nicotinamide phosphoribosyltransferase (Nampt) inhibitor APO866 depletes intracellular nicotinamide adenine dinucleotide (NAD(+)) and shows promising anticancer activity in preclinical studies. (unige.it)
  • A70: NAM is converted to nicotinamide mononucleotide (NMN) by nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12) (PMID: 19403820). (nih.gov)
  • A17: The rate-limiting protein in the conversion of NAM back to NAD+ is nicotinamide phosphoribosyltransferase (NAMPT), which catalyzes the reaction of nicotinamide into nicotinamide mononucleotide (NMN). (nih.gov)
  • NAD + biosynthesis via nicotinamide phosphoribosyltransferase (NAMPT) modulates SIRT1 activity. (esmo.org)
  • The results indicate that poly (ADP-ribose) polymerase (PARP) inhibitors synergized with nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. (nih.gov)
  • This result was explained by the observation that the NAMPT enzyme is the rate-limiting enzyme involved in the nicotinamide adenine dinucleotide (NAD+) salvage pathway, a necessary substrate of PARP. (nih.gov)
  • It is known that sirtuin activity is controlled by NAD pathways and nicotinamide phosphoribosyltransferase (NAMPT). (calerie.com)
  • NAMPT also named as Pre-B-cell colony-enhancing factor (PBEF) or visfatin, which is a limiting enzyme in the nicotinamide adenine dinucleotide (NAD+) salvage biosynthetic pathway. (paft-phil.com)
  • A series of tests pointed to a specific enzyme called adipokine nicotinamide phosphoribosyltransferase, (NAMPT), which is known to be involved in some of the pathological metabolic problems caused by obesity. (babiesbooksandbeyond.com)
  • In the body, NAMPT exists in two forms: an intracellular form, which regulates the production of nicotinamide adenine dinucleotide (NAD+), an important molecule for the generation of energy in the cell. (babiesbooksandbeyond.com)
  • Nevertheless, its conversion to NAD+ depends on rate-limiting enzymes like nicotinamide phosphoribosyltransferase (NAMPT). (wellnessdoctorrx.com)
  • Nicotinamide phosphoribosyltransferase is the enzyme that produces NMN in the human body (NAMPT). (antibodybiotech.com)
Deficiency2
  • Adenine phosphoribosyltransferase deficiency is a genetic disease, which means that it is caused by one or more genes not working correctly. (nih.gov)
  • Edvardsson VO, Sahota A, Palsson R. Adenine Phosphoribosyltransferase Deficiency. (medlineplus.gov)
Enzymes2
  • Nicotinamide adenine dinucleotide (NAD + ) is a central molecule in cellular metabolism and an obligate co-substrate for NAD + -consuming enzymes, which regulate key biological processes such as longevity and stress responses. (biologists.com)
  • Nicotinamide adenine dinucleotide (NAD + ) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on healthspan. (ultranmn.com)
Dinucleotide14
  • Nicotinamide adenine dinucleotide (NAD + ) is a crucial reductant in cellular biochemistry. (biologists.com)
  • A report in the journal CELL noted that the use of a derivative of vitamin B3/niacin called nicotinamide stimulates the production of nicotinamide adenine dinucleotide (NAD), a key protein in cellular metabolism (use of sugar for cellular energy) and cellular respiration (use of oxygen for cellular energy) in the mitochondria of cells. (resveratrolnews.com)
  • Nicotinic acid (NA) and nicotinamide (NAM) are major forms of niacin and exert their physiological functions as precursors of nicotinamide adenine dinucleotide (NAD). (resveratrolnews.com)
  • We reported that SIRT1, a nicotinamide adenine dinucleotide (NAD + )-dependent histone/protein deacetylase, is highly expressed in primary acute-type ATL cells. (esmo.org)
  • Mumumuviri, NMN inoshandiswa kugadzira nicotinamide adenine dinucleotide (NAD +), yakasimba uye yakakosha mamorekuru inowanikwa mune yese sero yemuviri. (aasraw.com)
  • NAD inomirira nicotinamide adenine dinucleotide. (aasraw.com)
  • It has been shown that the activity of nicotinamide adenine dinucleotide (NAD+) is related with the decline of Aβ toxicity in AD. (nih.gov)
  • This work incorporates our unique resource of treatment-naïve and treatment-resistant models to examine the role of NAD + (nicotinamide adenine dinucleotide) production, which is critical for energy use in these tumors, and how blocking this process may provide an innovative treatment approach. (thecurestartsnow.org)
  • Although neurons developed normally, mice without TOP1 showed motor deficits, exhibited lower levels of nicotinamide adenine dinucleotide (NAD-plus) - a compound critical in energy metabolism - and died prematurely. (nih.gov)
  • It is a building block for nicotinamide adenine dinucleotide (NAD). (calerie.com)
  • Sirtuins consist of 7 different proteins dependent on nicotinamide adenine dinucleotide (NAD+) that modulate DNA by expression and aging. (wellnessdoctorrx.com)
  • This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. (nih.gov)
  • May 03, 2017 · Nicotinamide adenine dinucleotide has 3 related precursor vitamins - nicotinamide, nicotinic acid, and nicotinamide riboside - that have highly efficient synthetic and recycling 'salvage' pathways and one 'detoxification' pathway using nicotinamide N-methyltransferase (NNMT). (metfur.pro)
  • May 31, 2020 · Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits mediated via elevated NAD+ content in the body. (metfur.pro)
Pathway1
  • We've investigated the potential of the GTP synthesis pathways as chemotherapeutic goals in the individual pathogen GTP biosynthesis, however, not the alternative salvage pathway, is crucial to cryptococcal dissemination and success pathway leads to slow development and virulence aspect defects, while lack of the cognate phosphoribosyltransferase in the salvage pathway yielded no phenotypes. (stopvivisection.info)
Nucleotide translocator1
Phosphate2
  • An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. (lookformedical.com)
  • adenine_ribotide_phosphate = 2 reactions were found. (tu-bs.de)
Mitochondria1
  • Specifically, it blocks adenine nucleotide efflux from mitochondria by enhancing membrane binding. (lookformedical.com)
Uracil3
  • In DNA, thymine complementary pairs with adenine whereas in RNA, uracil matches with adenine. (biologyonline.com)
  • Instead of uracil, DNA has thymine that complementary pairs with adenine. (biologyonline.com)
  • HPcytosine will spontaneously convert to N 6-HP-adenine and 3-HP-uracil, respectively. (who.int)
Enzyme called1
  • The enzyme called phosphoribosyltransferases (PRT) catalyzes the salvaging of purines. (dreamtech.nl)
Gene1
  • Add to 10265: Adenine B auxotroph, human complement for hamster Studying hybrids between hamster cells carrying induced auxotrophic mutation and normal human cells, Kao and Puck (1972) defined a linkage between an adenine B auxotroph complementing gene and a gene necessary for expression of three esterase bands (13335). (nih.gov)
Nicotinate1
  • 14. Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors. (nih.gov)
Cytosine2
  • Hypoxanthine, in particular, may faulty base pairs with cytosine because of its likeness to adenine (which pairs up naturally with thymine). (biologyonline.com)
  • 3-HP-, 1-HP-adenine, and 3-HP-cytosine. (who.int)
Cells1
  • The intriguing findings of our preliminary studies support a hypothesis that treatment-resistant cells have strong dependence on mediators of NAD + production, such as the enzyme QPRT (quinolinic acid phosphoribosyltransferase). (thecurestartsnow.org)
Renal1
  • Zyloric is indicated for the management of 2,8-dihydroxyadenine (2,8-DHA) renal stones related to deficient activity of adenine phosphoribosyltransferase. (medicines.org.uk)
Functional1
  • A lack of functional enzyme impairs the conversion of adenine to AMP. (medlineplus.gov)
Form1
APRT gene: MedlinePlus Genetics
APRT gene: MedlinePlus Genetics (medlineplus.gov)
MedlinePlus: Genetic Conditions
MedlinePlus: Genetic Conditions (medlineplus.gov)
Human Adenine Phosphoribosyltransferase (APRT) Protein (Myc-DYKDDDDK Tag), Recombinant | ABIN2714849
Human Adenine Phosphoribosyltransferase (APRT) Protein (Myc-DYKDDDDK Tag), Recombinant | ABIN2714849 (antikoerper-online.de)
Search Ageing-Associated Genes in Model Organisms
Search Ageing-Associated Genes in Model Organisms (genomics.senescence.info)
Sol Genomics Network
Sol Genomics Network (sgn.cornell.edu)
Leukocyte disease - Ontology Report - Rat Genome Database
Leukocyte disease - Ontology Report - Rat Genome Database (rgd.mcw.edu)
Integration of transcriptomic and proteomic analyses reveals several levels of metabolic regulation in the excess starch and...
Integration of transcriptomic and proteomic analyses reveals several levels of metabolic regulation in the excess starch and... (bmcplantbiol.biomedcentral.com)
HOMD :: SEQF1139
HOMD :: SEQF1139 (homd.org)
Steven C. Almo - Publications - Albert Einstein College of Medicine
Steven C. Almo - Publications - Albert Einstein College of Medicine (einstein.pure.elsevier.com)
OBM Geriatrics | Perspectives to Modify and Counter Aging in the Frame of Subtelomere-Telomere Theory of Aging
OBM Geriatrics | Perspectives to Modify and Counter Aging in the Frame of Subtelomere-Telomere Theory of Aging (lidsen.com)
Coffea arabica L. - ICG
Coffea arabica L. - ICG (icg.big.ac.cn)
Network Portal - Gene CAC0083
Network Portal - Gene CAC0083 (networks.systemsbiology.net)
Difference between revisions of Coffea arabica L. - ICG
Difference between revisions of "Coffea arabica L." - ICG (icg.big.ac.cn)
STEPdb: Sub-cellular Topologies of E.coli Polypeptides.
STEPdb: Sub-cellular Topologies of E.coli Polypeptides. (versionone.stepdb.eu)
List of EC numbers (EC 2)
List of EC numbers (EC 2) (en-academic.com)
Difference between revisions of Solanum tuberosum - ICG
Difference between revisions of "Solanum tuberosum" - ICG (icg.big.ac.cn)
SACOL1079 - AureoWiki
SACOL1079 - AureoWiki (aureowiki.med.uni-greifswald.de)
J Integr Plant Biol
J Integr Plant Biol (jipb.net)
Adenine Phosphoribosyltransferase Deficiency - GeneReviews® - NCBI Bookshelf
Adenine Phosphoribosyltransferase Deficiency - GeneReviews® - NCBI Bookshelf (ncbi.nlm.nih.gov)
Adenine phosphoribosyltransferase deficiency - About the Disease - Genetic and Rare Diseases Information Center
Adenine phosphoribosyltransferase deficiency - About the Disease - Genetic and Rare Diseases Information Center (rarediseases.info.nih.gov)
Adenine phosphoribosyltransferase deficiency - Getting a Diagnosis - Genetic and Rare Diseases Information Center
Adenine phosphoribosyltransferase deficiency - Getting a Diagnosis - Genetic and Rare Diseases Information Center (rarediseases.info.nih.gov)