Adenine Nucleotide Translocator 1: A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).Mitochondrial ADP, ATP Translocases: A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization.Adenine Nucleotide Translocator 2: A subtype of mitochondrial ADP, ATP translocase found primarily in FIBROBLASTS.Atractyloside: A glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEPIS. Toxicity is due to inhibition of ADENINE NUCLEOTIDE TRANSLOCASE.Bongkrekic Acid: An antibiotic produced by Pseudomonas cocovenenans. It is an inhibitor of MITOCHONDRIAL ADP, ATP TRANSLOCASES. Specifically, it blocks adenine nucleotide efflux from mitochondria by enhancing membrane binding.Adenine NucleotidesAdenine Nucleotide Translocator 3: A subtype of mitochondrial ADP, ATP translocase found primarily in the LIVER.Oxidative Phosphorylation: Electron transfer through the cytochrome system liberating free energy which is transformed into high-energy phosphate bonds.Mitochondria: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)Mitochondria, Liver: Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)Nucleotidyltransferases: A class of enzymes that transfers nucleotidyl residues. EC 2.7.7.Intracellular Membranes: Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Voltage-Dependent Anion Channels: A family of voltage-gated eukaryotic porins that form aqueous channels. They play an essential role in mitochondrial CELL MEMBRANE PERMEABILITY, are often regulated by BCL-2 PROTO-ONCOGENE PROTEINS, and have been implicated in APOPTOSIS.Mitochondrial Membrane Transport Proteins: Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.Mitochondrial Swelling: An increase in MITOCHONDRIAL VOLUME due to an influx of fluid; it occurs in hypotonic solutions due to osmotic pressure and in isotonic solutions as a result of altered permeability of the membranes of respiring mitochondria.Mitochondria, Heart: The mitochondria of the myocardium.Adenine: A purine base and a fundamental unit of ADENINE NUCLEOTIDES.Oxygen Consumption: The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)Cyclophilins: A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-Membrane Potential, Mitochondrial: The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.Uncoupling Agents: Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.Cell Respiration: The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell.Permeability: Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.Aryl Hydrocarbon Receptor Nuclear Translocator: Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with DIOXIN RECEPTOR. The complex binds xenobiotic regulatory elements and activates transcription of a variety of genes including UDP GLUCURONOSYLTRANSFERASE. AhR nuclear translocator is also a subunit of HYPOXIA-INDUCIBLE FACTOR 1.Proto-Oncogene Proteins c-bcl-2: Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.Mitochondrial Proteins: Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.Nucleotides: The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Kinetics: The rate dynamics in chemical or physical systems.DNA, Mitochondrial: Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Receptors, GABA: Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.Receptors, Aryl Hydrocarbon: Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.Energy Metabolism: The chemical reactions involved in the production and utilization of various forms of energy in cells.Purine Nucleotides: Purines attached to a RIBOSE and a phosphate that can polymerize to form DNA and RNA.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Guanine NucleotidesAdenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Hypoxanthines: Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.Pseudogenes: Genes bearing close resemblance to known genes at different loci, but rendered non-functional by additions or deletions in structure that prevent normal transcription or translation. When lacking introns and containing a poly-A segment near the downstream end (as a result of reverse copying from processed nuclear RNA into double-stranded DNA), they are called processed genes.Solute Carrier Family 12, Member 4: K-Cl cotransporter ubiquitously expressed with higher expression levels in ERYTHROCYTES of ANEMIA, SICKLE CELL. It mediates active potassium and chloride cotransport across the plasma membrane and contributes to cell volume homeostasisSearch Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Solute Carrier Family 12, Member 3: Na-Cl cotransporter in the convoluted segments of the DISTAL KIDNEY TUBULE. It mediates active reabsorption of sodium and chloride and is inhibited by THIAZIDE DIURETICS.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.

Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells. (1/10)

Mitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce apoptosis. Nothing is known, however, about the apoptotic activity of ANT3. We have transfected HeLa cells with the three human ANT isoforms to compare their potential as inducers of apoptosis. Transient overexpression of ANT3 resulted, like ANT1, in apoptosis as shown by an increase in the sub-G1 fraction, annexin V staining, low DeltaPsi(m), and activation of caspases 9 and 3. Moreover, the apoptosis produced by ANT3 was inhibited by bongkrekic acid and by cyclosporin A. The pro-apoptotic activities of the ANT1 and ANT3 isoforms contrast with the lack of apoptotic activity of ANT2. This finding may help to identify the specific factors associated with the pro-apoptotic activities of ANT isoforms.  (+info)

Effects of extramitochondrial ADP on permeability transition of mouse liver mitochondria. (2/10)

Carboxyatractylate (CAT) and atractylate inhibit the mitochondrial adenine nucleotide translocator (ANT) and stimulate the opening of permeability transition pore (PTP). Following pretreatment of mouse liver mitochondria with 5 microM CAT and 75 microM Ca2+, the activity of PTP increased, but addition of 2 mM ADP inhibited the swelling of mitochondria. Extramitochondrial Ca2+ concentration measured with Calcium-Green 5N evidenced that 2 mM ADP did not remarkably decrease the free Ca2+ but the release of Ca2+ from loaded mitochondria was stopped effectively after addition of 2 mM ADP. CAT caused a remarkable decrease of the maximum amount of calcium ions, which can be accumulated by mitochondria. Addition of 2 mM ADP after 5 microM CAT did not change the respiration, but increased the mitochondrial capacity for Ca2+ at more than five times. Bongkrekic acid (BA) had a biphasic effect on PT. In the first minutes 5 microM BA increased the stability of mitochondrial membrane followed by a pronounced opening of PTP too. BA abolished the action about of 1 mM ADP, but was not able to induce swelling of mitochondria in the presence of 2 mM ADP. We conclude that the outer side of inner mitochondrial membrane has a low affinity sensor for ADP, modifying the activity of PTP. The pathophysiological importance of this process could be an endogenous prevention of PT at conditions of energetic depression.  (+info)

Dinitrophenol-induced mitochondrial uncoupling in vivo triggers respiratory adaptation in HepG2 cells. (3/10)

Here, we show that 3 days of mitochondrial uncoupling, induced by low concentrations of dinitrophenol (10 and 50 microM) in cultured human HepG2 cells, triggers cellular metabolic adaptation towards oxidative metabolism. Chronic respiratory uncoupling of HepG2 cells induced an increase in cellular oxygen consumption, oxidative capacity and cytochrome c oxidase activity. This was associated with an upregulation of COXIV and ANT3 gene expression, two nuclear genes that encode mitochondrial proteins involved in oxidative phosphorylation. Glucose consumption, lactate and pyruvate production and growth rate were unaffected, indicating that metabolic adaptation of HepG2 cells undergoing chronic respiratory uncoupling allows continuous and efficient mitochondrial ATP production without the need to increase glycolytic activity. In contrast, 3 days of dinitrophenol treatment did not change the oxidative capacity of human 143B.TK(-) cells, but it increased glucose consumption, lactate and pyruvate production. Despite a large increase in glycolytic metabolism, the growth rate of 143B.TK(-) cells was significantly reduced by dinitrophenol-induced mitochondrial uncoupling. We propose that chronic respiratory uncoupling may constitute an internal bioenergetic signal, which would initiate a coordinated increase in nuclear respiratory gene expression, which ultimately drives mitochondrial metabolic adaptation within cells.  (+info)

Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats. (4/10)

We proposed that inhibition of mitochondrial adenine nucleotide translocator (ANT) by long chain acyl-CoA (LCAC) underlies the mechanism associating obesity and type 2 diabetes. Here we test that after long-term exposure to a high-fat diet (HFD): (i) there is no adaptation of the mitochondrial compartment that would hinder such ANT inhibition, and (ii) ANT has significant control of the relevant aspects of oxidative phosphorylation. After 7 weeks, HFD induced a 24+/-6% increase in hepatic LCAC concentration and accumulation of the oxidative stress marker N(epsilon)-(carboxymethyl)lysine. HFD did not significantly affect mitochondrial copy number, oxygen uptake, membrane potential (Deltapsi), ADP/O ratio, and the content of coenzyme Q(9), cytochromes b and a+a(3). Modular kinetic analysis showed that the kinetics of substrate oxidation, phosphorylation, proton leak, ATP-production and ATP-consumption were not influenced significantly. After HFD-feeding ANT exerted considerable control over oxygen uptake (control coefficient C=0.14) and phosphorylation fluxes (C=0.15), extra- (C=0.23) and intramitochondrial (C=-0.56) ATP/ADP ratios, and Deltapsi (C=-0.11). We conclude that although HFD induces accumulation of LCAC and N(epsilon)-(carboxymethyl)lysine, oxidative phosphorylation does not adapt to these metabolic challenges. Furthermore, ANT retains control of fluxes and intermediates, making inhibition of this enzyme a more probable link between obesity and type 2 diabetes.  (+info)

Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. (5/10)

Mitochondrial adenine nucleotide translocase (ANT) is believed to be a component or a regulatory component of the mitochondrial permeability transition pore (mtPTP), which controls mitochondrial permeability transition during apoptosis. However, the role of ANT in apoptosis is still uncertain, because hepatocytes isolated from ANT knockout and wild-type mice are equally sensitive to TNF- and Fas-induced apoptosis. In a screen for genes required for tumor necrosis factor alpha (TNF-alpha)-induced apoptosis in MCF-7 human breast cancer cells using retrovirus insertion-mediated random mutagenesis, we discovered that the ANT3 gene is involved in TNF-alpha-induced cell death in MCF-7 cells. We further found that ANT3 is selectively required for TNF- and oxidative stress-induced cell death in MCF-7 cells, but it is dispensable for cell death induced by several other inducers. This data supplements previous data obtained from ANT knockout studies, indicating that ANT is involved in some apoptotic processes. We found that the resistance to TNF-alpha-induced apoptosis observed in ANT3 mutant (ANT3(mut)) cells is associated with a deficiency in the regulation of the mitochondrial membrane potential and cytochrome c release. It is not related to intracellular ATP levels or survival pathways, supporting a previous model in which ANT regulates mtPTP. Our study provides genetic evidence supporting a role of ANT in apoptosis and suggests that the involvement of ANT in cell death is cell type- and stimulus-dependent.  (+info)

Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells. (6/10)

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Overexpression of GAP-43 reveals unexpected properties of hippocampal mossy fibers. (7/10)

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Full-length enriched cDNA library construction from tissues related to energy metabolism in pigs. (8/10)

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OBJECTIVES:. Assess the efficacy of raising and maintaining hemoglobin (Hgb) levels above 12.0 g/dL with epoetin alfa vs maintaining Hgb levels above 10.0 g/dL without epoetin alfa on progression-free survival, overall survival, and local control in anemic patients with cervical cancer receiving concurrent radiotherapy and cisplatin. Compare the quality of life of patients treated with these regimens.. OUTLINE:. This is a randomized study. Patients are stratified according to stage (IIB vs IIIB vs IVA), method of brachytherapy (low-dose vs high-dose), and surgical staging of para-aortic nodes (yes vs no). Patients are randomized to 1 of 2 treatment arms.. Arm I: Patients undergo radiotherapy comprising pelvic external beam radiotherapy daily five days a week for 5 weeks, followed by either 1 or 2 implants of low-dose rate intracavitary brachytherapy or 5 fractions of high-dose rate intracavitary brachytherapy, followed by 3-5 days of parametrial boost radiotherapy. Patients receive cisplatin IV ...
Sigma-Aldrich offers abstracts and full-text articles by [I R Kniazeva, V V Ivanov, M A Bolshakov, L P Zharkova, A V Kereia, O P Kutenkov, V V Rostov].
A study on Anole lizards deliberately introduced to various islands found much the same thing. It seems that phenotypic plasticity can take up the slack in the short term, resulting in physical changes without the need for any genetic change. The same may be the case in this instance ...
anole lizard stock photography , travel photography and stock images of travel destinations worldwide by award winning travel photographer David Sanger
Anoles are part of the Dactyloidae family. They are native to the warmer parts of North America. Anoles are either a green or a brownish color average size is around 15cm in total length. They have some of the characteristics as geckos as having the same foot structure for climbing and can break off part of its tail to
Unique research by UC Riverside biologists on wild anole lizards reveals new insights on how animals might adapt to their habitat and handle various forms of motion.
Green Anole Stock Photo. csp7390979 - Male green anole lizard found in puerto rico forest. Affordable Royalty Free Stock Photography. Downloads for just $2.50, with thousands of images added daily. Subscriptions available for just $39.00. Our stock photo image search engine contains royalty free photos, vector clip art images, clipart illustrations.
Evading a hungry predator is essential if your genes are to contribute to the game of life and speed is usually of the essence. However, its not always that simple. Animals often drop their speed in favour of agility as they try to outmanoeuvre pursuers. And what happens if you take the pursuit into the trees, where prey have to negotiate branches of different girth? Wondering how green anole lizards adapt their flight in different contexts, Erik Sathe and Jerry Husak from the University of St Thomas, USA, began investigating how animals of different builds sprinted along branches of different widths, along the flat and through a maze of peg obstacles to find out which physical attributes prepared the lizards best for escape.. Sure enough, the sprinting animals were fastest on a flat surface and the broadest pole (5 cm), reaching speeds of over 1.4 m s−1, but they dropped to 0.8 m s−1 on the 2.5 cm pole and were reduced to a crawl (0.4 m s−1) through the maze of pegs. Next, they ...
This film explores the adaptation of anole lizards (genus Anolis) to habitats common across the islands of the Caribbean. The anoles are excellent examples of adaptive radiation, convergent evolution, and speciation through reproductive isolation.. ...
In seven interactive virtual labs, identify bacteria, examine heart patients, probe the nervous system, assay antibodies, study circadian rhythms, and analyze evolution in action in stickleback fish. Lizard Evolution Virtual Lab: Explore the evolution of the anole lizards in the Caribbean.... ...
In seven interactive virtual labs, identify bacteria, examine heart patients, probe the nervous system, assay antibodies, study circadian rhythms, and analyze evolution in action in stickleback fish. Lizard Evolution Virtual Lab: Explore the evolution of the anole lizards in the Caribbean.... ...
The Barbados anole (Anolis extremus) is a species of anole lizard that is native to Barbados, an island-nation in the Caribbean. Originally endemic to Barbados, it has since been introduced to Saint Lucia and Bermuda. It was previously treated as a subspecies of Martiniques anole (A. roquet). Males have pale lavender to blue-gray heads, with blue eyelids. Their dorsal surfaces are deep green with dark markings and occasionally white spots, and their bellies are yellow. Females are smaller and duller in color and may have a mid-dorsal stripe. It remains widespread and abundant on Barbados, where it is the only anole species. It adapts well to populated environments. It has been reported in Florida since the 1990s, though this is likely due to repeated introductions and escapes as a sustained, breeding population has not been confirmed. List of Anolis lizards Malhotra & Thorpe 1999, pp. 97, 119. Description of both sexes at Malhotra & Thorpe 1999, p. 97. Malhotra & Thorpe 1999, p. 97; Government ...
As in the rabbit, dBSA tended to enhance the CCCP fee, but this was only major for succinate alone (P,.05). Not like the rabbit tubules, basal and oligomycin
Copyright 2012 by Jenny A. Gubler. This material is copyrighted and any further reproduction or distribution is prohibited without the permission of the copyright owner ...
Copyright 2012 by Jenny A. Gubler. This material is copyrighted and any further reproduction or distribution is prohibited without the permission of the copyright owner ...
Rabbit polyclonal Adenine Nucleotide Translocator 2 antibody validated for WB, IP and tested in Human. With 2 independent reviews. Immunogen corresponding to…
Synonyms for Adenine nucleotide translocator in Free Thesaurus. Antonyms for Adenine nucleotide translocator. 1 synonym for adenine: A. What are synonyms for Adenine nucleotide translocator?
Adenine Nucleotide Translocator 1: A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).
Anole Bourbon Nut Brown brewed by Dead Lizard Brewing Company as an Brown Ale - American style beer, which has 3.5 out of 5, with 442 ratings and reviews on Untappd.
Looking for online definition of adenine nucleotide translocator 1 in the Medical Dictionary? adenine nucleotide translocator 1 explanation free. What is adenine nucleotide translocator 1? Meaning of adenine nucleotide translocator 1 medical term. What does adenine nucleotide translocator 1 mean?
George Gorman, who pioneered the use of molecular tools to study anole phylogenetics from the late 1960s to the early 1980s, asks:. "Why not examine karyotypes of Dactyloa?". He says:. "In the 1960s and 70s, before the DNA revolution, the systematic examination of karyotypes of reptilian taxa mushroomed, and, to some extent helped orient our thinking about relationships among various clades. This was certainly the case within Anolis at various hierarchical levels, from species determination to definition of distinct species groups. To my knowledge, there has been very little added to our knowledge about karyotypes of mainland Anolis that Etheridge placed in the latifrons series of Alpha Anolis, now frequently referred to as the Dactyloa clade. (if these are long-lost terms, Etheridges Beta anoles are the Norops section; all other lineages are within his "Alpha" section).. Background. There is a very pervasive, either primitive or convergently arrived at, karyotype among the ...
Ok, so I found a free anole in my terrarium which probably hatched out of one of my plants that Id ordered. That doesnt men havent spent a lot on h
Graham BH et al. (1997) A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator.. [^] ...
Got ant problems and wondering what kills ants? Heres how to get rid of ants with items you already own-and learn how to kill ants for good.
Slc25a4 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 (cDNA clone, (10ug), 10 µg.
Bongkrekic acid (BKA) is a strong inhibitor of adenine nucleotide translocase (ANT), inducing inhibition of adenosine triphosphate synthesis. We designed and synthesized simplified benzene-ring-containing BKA analogs. The key reaction is the one-pot double Sonogashira reaction, which forms the main skeleton. The analogs were efficiently synthesized in 8-10 longest linear sequence steps. This synth ...
I know I read someones comments about ants in their RV but I cant find the thread. CRS perhaps. Anyway. Prior to loading up the other day the wife says there are ants in the bedroom of the MH. What
"Entrez Gene: SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31". Gallerne C ... "Computational analysis of the transcriptional regulation of the adenine nucleotide translocator isoform 4 gene and its role in ... "The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells". The International ... Chevrollier A, Loiseau D, Reynier P, Stepien G (Jun 2011). "Adenine nucleotide translocase 2 is a key mitochondrial protein in ...
Ku DH, Kagan J, Chen ST, Chang CD, Baserga R, Wurzel J (Sep 1990). "The human fibroblast adenine nucleotide translocator gene. ... The product of this gene, adenine nucleotide translocator 2 (ANT2), functions as a major constituent of the mitochondrial ... Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 is a protein that in humans is ... adenine nucleotide translocator), member 5". Retrieved 2013-09-18. Chevrollier A, Loiseau D, Reynier P, Stepien G (Jun 2011). " ...
Kim JY, So KJ, Lee S, Park JH (Sep 2012). "Bcl-rambo induces apoptosis via interaction with the adenine nucleotide translocator ... Bcl-rambo mediates apoptosis by associating with adenine nucleotide translocator (ANT), a component of the mitochondrial ... 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. Banga S, Gao P, Shen X, Fiscus V, Zong WX, Chen L, Luo ZQ (Mar ... 534 (1-3): 61-8. doi:10.1016/S0014-5793(02)03778-X. PMID 12527362. Human BCL2L13 genome location and BCL2L13 gene details page ...
"The role of adenine nucleotide translocator in regulation of oxidative phosphorylation in heart mitochondria". FEBS Letters. ... "Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat ... 3: 145-154. doi:10.1142/s0218339095000149. Cascante, M.; Melendez-Hevia, E.; Kholodenko, B.N.; Sicilia, J.; Kacser, H. (1995 ... doi:10.1016/s0014-5793(99)01058-3. Kholodenko, B.N., Demin, O.V.; Moehren, G.; Hoek, J.B. (1999). "Quantification of short-term ...
"Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science. 281 (5385): 2027-31. ... 2 (3): 238-40. doi:10.4161/auto.2730. PMID 16874066. [permanent dead link] Weng C, Li Y, Xu D, Shi Y, Tang H (March 2005). " ... Nomura M, Shimizu S, Sugiyama T, Narita M, Ito T, Matsuda H, Tsujimoto Y (2003). "14-3-3 Interacts directly with and negatively ... 278 (3): 2058-65. doi:10.1074/jbc.M207880200. PMID 12426317. Hoppins, Suzanne; Edlich, Frank; Cleland, Megan M.; Banerjee, ...
Jang JY, Lee CE (2003). "Mitochondrial adenine nucleotide translocator 3 is regulated by IL-4 and IFN-gamma via STAT-dependent ... Adenine nucleotide translocator Solute carrier family GRCh38: Ensembl release 89: ENSG00000169100 - Ensembl, May 2017 "Human ... 2001). "A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family". Neurology. 57 (12): 2295-8. ... 2002). "A novel D104G mutation in the adenine nucleotide translocator 1 gene in autosomal dominant progressive external ...
AGK also has an implicated role in the assembly of the adenine nucleotide translocator in the inner mitochondrial membrane. ... 50 (3): 363-71. doi:10.1007/s00592-012-0422-1. PMID 22864860. Human AGK genome location and AGK gene details page in the UCSC ... ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate. The enzyme is involved in the more general pathway of ... In the proliferation of prostate cancer, AGK interacts with and regulates PC-3 prostate cancer cells markedly increased ...
2001). "Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral ... 1988). "Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1". Nucleic Acids Res. 16 (8): 3577. doi: ... Yuan J, Murrell GA, Trickett A, Wang MX (2003). "Involvement of cytochrome c release and caspase-3 activation in the oxidative ... doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Valnot I, Kassis J, Chretien D, et al. (1999). "A mitochondrial cytochrome b ...
... adenine nucleotide translocator 1 MeSH D12.776.575.750.500.200 - adenine nucleotide translocator 2 MeSH D12.776.575.750.500.300 ... adenine nucleotide translocator 3 MeSH D12.776.580.210.175.325 - groes protein MeSH D12.776.580.210.180.325 - groel protein ... actin-related protein 3 MeSH D12.776.220.525.475.100 - myosin heavy chains MeSH D12.776.220.525.475.200 - myosin light chains ... type 3 MeSH D12.776.624.664.700.130 - muts homolog 2 protein MeSH D12.776.624.664.700.148 - myeloid-lymphoid leukemia protein ...
... adenine nucleotide translocator 1 MeSH D12.776.157.530.625.875.500.200 -- adenine nucleotide translocator 2 MeSH D12.776. ... 157.530.625.875.500.300 -- adenine nucleotide translocator 3 MeSH D12.776.157.530.750.100 -- aryl hydrocarbon receptor nuclear ... nucleotide transport proteins MeSH D12.776.157.530.625.875.500 -- mitochondrial adp, atp translocases MeSH D12.776.157.530. ... translocator MeSH D12.776.157.530.750.200 -- cellular apoptosis susceptibility protein MeSH D12.776.157.530.750.500 -- ...
Adenine nucleotide translocator (ANT) 2.B: Nonribosomally synthesized porters, such as The Nigericin (Nigericin) Family The ... such as rhodopsin The group translocators provide a special mechanism for the phosphorylation of sugars as they are transported ... 38 (3): 305-315. doi:10.1016/j.tips.2016.11.008. ISSN 1873-3735. PMID 27939446. Sadava, David, et al. Life, the Science of ... 38 (3): 305-315. doi:10.1016/j.tips.2016.11.008. ISSN 1873-3735. PMID 27939446. Sherwood, Lauralee. 7th Edition. Human ...
... adenine nucleotide translocator-3 on the Y), SOX21 (known to cause baldness), AZF2 (azoospermia factor 2), BPY2 (basic protein ... interleukin-3 receptor), SRY (sex-determining region), TDF (testis determining factor), ZFY (zinc finger protein), PRKY ( ...
... adenine nucleotide translocator 1 MeSH D12.776.543.585.450.162.235.200 -- adenine nucleotide translocator 2 MeSH D12.776. ... adenine nucleotide translocator 1 MeSH D12.776.543.585.625.875.500.200 -- adenine nucleotide translocator 2 MeSH D12.776. ... 543.585.625.875.500.300 -- adenine nucleotide translocator 3 MeSH D12.776.543.585.750.100 -- aryl hydrocarbon receptor nuclear ... adenine nucleotide translocator 3 MeSH D12.776.543.585.450.162.276 -- potassium-hydrogen antiporters MeSH D12.776.543.585. ...
... 1 at the US National Library of Medicine Medical Subject Headings (MeSH) Adenine Nucleotide ... Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocator, exports ATP from the mitochondrial matrix and ... Translocator 2 at the US National Library of Medicine Medical Subject Headings (MeSH) Adenine Nucleotide Translocator 3 at the ... "Role of adenine nucleotide translocator 1 in mtDNA maintenance". Science. 289 (5480): 782-785. doi:10.1126/science.289.5480.782 ...
UCP1 is related to other mitochondrial metabolite transporters such as the adenine nucleotide translocator, a proton channel in ... UCP1 is activated in the brown fat cell by fatty acids and inhibited by nucleotides. Fatty acids cause the following signaling ... overriding the inhibition caused by purine nucleotides (GDP and ADP). During the termination of thermogenesis, thermogenin is ... 44 (3): 373-6. doi:10.1007/s001250051629. PMID 11317671. Nibbelink M, Moulin K, Arnaud E, Duval C, Pénicaud L, Casteilla L (Dec ...
ADP/ATP translocase 1 is an enzyme that in humans is encoded by the SLC25A4 gene or adenine nucleotide translocator, ANT. ... "Entrez Gene: SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4". Marzo I, ... "Deficiency of the adenine nucleotide translocator in muscle of a patient with myopathy and lactic acidosis: a new mitochondrial ... "A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed ...
... thiols in the mitochondrial permeability transition pore component adenine nucleotide translocator (ANT). Overexpression of ... "Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer". Cancer Research. ... 443 (3): 821-7. doi:10.1016/j.bbrc.2013.12.050. PMID 24342608. Wang Z, Zhang H, Li XF, Le XC (2007). "Study of interactions ... Two mRNA transcripts of the TXN2 gene differ by ~330 bp in the length of the 3′-untranslated region, and both are believed to ...
... the inner membrane protein adenine nucleotide translocator (AdNT) and the matrix protein cyclophilin D (CyD) (12). This pore ... It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. ... A short linker and nucleotide binding a/b domains (NBD) that contain conserved Walker boxes A (p-loop 155-161) and B (239-243) ... Another model proposes that Apaf-1 is organized in an extended fashion such that both the N-terminal CARD and the nucleotide ...
Adenine nucleotide translocator. *Adenosine deaminase. *Adenosylmethionine decarboxylase. *Adenylosuccinate synthase. *AdoMet ...
SLC25A25 adenine nucleotide - SLC25A4, SLC25A5, SLC25A6, SLC25A31 dicarboxylate - SLC25A10 oxoglutarate - SLC25A11 glutamate - ... "Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential". Journal ... nucleotides, amino acids, keto acids and cofactors across the membrane. Such proteins include: ADP/ATP carrier protein (ADP-ATP ... nucleotides, inorganic ions and co-factors through the mitochondrial inner membrane. The transporters consist of six ...
Further hypothesis by Halestrap´s group convincingly suggested the MPT was formed by the inner membrane Adenine Nucleotide ... "The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore". Nature. 427 (6973): 461-465. doi ... "The nature of the calcium ion efflux induced in rat liver mitochondria by the oxidation of endogenous nicotinamide nucleotides ... "Regulation of the Inner Membrane Mitochondrial Permeability Transition by the Outer Membrane Translocator Protein (Peripheral ...
Adenine Nucleotide Translocator 1: A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM ... Adenine Nucleotide Translocator 1. Subscribe to New Research on Adenine Nucleotide Translocator 1 ... ANT-1 Transport Protein; ANT1 Transport Protein; Adenine Nucleotide Carrier Protein; Adenine Nucleotide Translocator, Muscle ... Nucleotide Transport Proteins*ATP Translocases Mitochondrial ADP: 95*Adenine Nucleotide Translocator 1: 14 ...
Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 ... adenine nucleotide translocator) in the mediation of this UCP1-independent fatty-acid-induced uncoupling in brown-fat ... Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 ... Uncoupling protein 1 inhibition by purine nucleotides is under the control of the endogenous ubiquinone redox state Biochem J ( ...
Antonyms for Adenine nucleotide translocator. 1 synonym for adenine: A. What are synonyms for Adenine nucleotide translocator? ... Synonyms for Adenine nucleotide translocator in Free Thesaurus. ... Related to Adenine nucleotide translocator: adenine nucleotide ... Adenine nucleotide translocator synonyms, Adenine nucleotide translocator antonyms - FreeThesaurus.com https://www. ... adenine. (redirected from Adenine nucleotide translocator). Also found in: Dictionary, Medical, Acronyms, Encyclopedia, ...
Stepien G, Torroni A, Chung AB, Hodge JA, Wallace DC: Differential expression of adenine nucleotide translocator isoforms in ... Adenine nucleotide translocase-2 (ANT2), one of the four adenine nucleotide translocase isoforms expressed in humans, is ... Adenine nucleotide translocase, a protein located in the inner mitochondrial membrane, catalyzes the exchange of mitochondrial ... Jang JY, Jeon YK, Kim CW: Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells ...
Rabbit polyclonal Adenine Nucleotide Translocator 2/ANT 2 antibody. Validated in WB, IHC and tested in Human. Independently ... Anti-Adenine Nucleotide Translocator 2/ANT 2 antibody. See all Adenine Nucleotide Translocator 2/ANT 2 primary antibodies. ... All lanes : Anti-Adenine Nucleotide Translocator 2/ANT 2 antibody (ab221956) at 1/100 dilution. Lane 1 : RT-4 cell lysate. Lane ... This product Rabbit Anti-Adenine Nucleotide Translocator 2/ANT 2 antibody (ab221956) IHC-P, WB ...
Rabbit polyclonal Adenine Nucleotide Translocator 2 antibody validated for WB, IP and tested in Human. With 2 independent ... Anti-Adenine Nucleotide Translocator 2 antibody. See all Adenine Nucleotide Translocator 2 primary antibodies. ... Immunoprecipitation of Adenine Nucleotide Translocator 2 transfected lysate using ab118125 and Protein A Magnetic Bead, and ... Recombinant full length protein, corresponding to amino acids 1-298 of Human Adenine Nucleotide Translocator 2 (NP_001143.2). ...
Adenine nucleotide translocator 1 (IPR002113). Homologous superfamilies. * Homologous superfamily. 1 50 100 150 200 250 298 ...
Adenine nucleotide translocator 3. Short name: ANT 3. ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_ ... purine nucleotide transport Source: TAIRInferred from direct assayi*. "Functional integration of mitochondrial and ... Nucleotide carrier signature motifBy similarity. Manual assertion inferred from sequence similarity toi ... ADP,ATP carrier protein 3, mitochondrialAdd BLAST. 310. Proteomic databases. PaxDb, a database of protein abundance averages ...
"Entrez Gene: SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31". Gallerne C ... "Computational analysis of the transcriptional regulation of the adenine nucleotide translocator isoform 4 gene and its role in ... "The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells". The International ... Chevrollier A, Loiseau D, Reynier P, Stepien G (Jun 2011). "Adenine nucleotide translocase 2 is a key mitochondrial protein in ...
Deficiency of the adenine nucleotide translocator in muscle of a patient with myopathy and lactic acidosis: a new mitochondrial ... The adenine nucleotide translocator (ANT) transports ATP out of the mitochondrion. Deficiencies have been found in all OXPHOS ... adenine nucleotide translocator; mtDNA, mitochondrial DNA; CCCP, carbonyl cyanide 3-chlorophenyl hydrazone; CS, citrate ... 3.) De Meirleir L. Defects of pyruvate metabolism and the Krebs cycle. J Child Neurol 2002;17:26-33. (4.) Triepels RH, Hanson ...
Ku DH, Kagan J, Chen ST, Chang CD, Baserga R, Wurzel J (Sep 1990). "The human fibroblast adenine nucleotide translocator gene. ... The product of this gene, adenine nucleotide translocator 2 (ANT2), functions as a major constituent of the mitochondrial ... Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 is a protein that in humans is ... adenine nucleotide translocator), member 5". Retrieved 2013-09-18. Chevrollier A, Loiseau D, Reynier P, Stepien G (Jun 2011). " ...
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science (1998) 281:2027-31. doi: ... ANT, adenine nucleotide translocator; Bax, Bcl-2-associated protein X; Bak, Bcl-2 homologous antagonist killer; Bcl-2, B-cell ... Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator. Oncogene (2000) 19:329-36. ... the adenine nucleotide translocator ANT-2 is upregulated in renal tumors and transformed hepatocytes (78). This upregulation, ...
Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6, Pseudogene 1 2 3 ... Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6 Pseudogene 3 ... Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 5-Like 2 ... The GeneCards human gene database index: 1 2 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
Protein Aliases: AAC3; adenine nucleotide translocator 2; Adenine nucleotide translocator 3; adenine nucleotide translocator 3 ... adenine nucleotide translocator), member 6; Solute carrier family 25 member 6; solute carrier family 25, member A6 ... translation protein targeting to mitochondrion apoptotic process adenine transport ADP transport ATP transport active induction ... structural constituent of ribosome ATP:ADP antiporter activity protein binding adenine transmembrane transporter activity ...
Abbreviations: ANT, adenine nucleotide translocator; BMI, body mass index; MPTP, mitochondrial permeability transition pore; ...
The objective of this study was to identify single-nucleotide polymorphisms using a bovine chromosome 14 high-density SNP panel ... 8100217 - Genetic mapping of human heart-skeletal muscle adenine nucleotide translocator and its .... 19025667 - Chromosomal ... The objective of this study was to identify single-nucleotide polymorphisms using a bovine chromosome 14 high-density SNP panel ... One SNP in particular, ss61514555:A,C, showed association with 3 of the 5 traits: milk (p = 1.59E-04), fat (p = 6.88E-05) and ...
Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup. Proc ... Complete loss-of-function of the heart/muscle-specific adenine nucleotide translocator is associated with mitochondrial ... The adenine nucleotide translocase type 1 (ANT1): a new factor in mitochondrial disease. IUBMB Life. 2005 Sep;57(9):607-14. ... The SLC25A4 gene provides the instructions for making a protein called adenine nucleotide translocase type 1 (ANT1). ANT1 ...
"Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes in Arabidopsis thaliana are ... The adenine nucleotide translocator of higher plants is synthesized as a large precursor that is processed upon import into ... Two genes encode the adenine nucleotide translocator of maize mitochondria. Isolation, characterisation and expression of the ... Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes... Carrie, Chris; Murcha, ...
Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction. ... myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. ... The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. ... Diet-induced obesity in two C57BL/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) gene. ...
Increased levels of adenine nucleotide translocator 1 protein and response to oxidative stress are early events in ... DUX4 transcript from the last D4Z4 (most telomeric) unit generates small si/miRNA-sized fragments; uncapped, polyadenylated 3- ...
... adenine nucleotide translocator 2 , adenine nucleotide translocator 3 (liver) , solute carrier family 25, member A6 , ... Adenine Nucleotide Translocator), Member 5 ELISA Kits * Solute Carrier Family 25 (Mitochondrial Carrier, Adenine Nucleotide ... Solute Carrier Family 25 (Mitochondrial Carrier, Adenine Nucleotide Translocator), Member 6 (SLC25A6) ELISA Kits. SLC25A6 is a ... Cow (Bovine) Solute Carrier Family 25 (Mitochondrial Carrier, Adenine Nucleotide Translocator), Member 6 (SLC25A6) interaction ...
The human adenine nucleotide translocator sub-family is composed of four isoforms, namely ANT1-4, encoded by four nuclear genes ... The adenine nucleotide translocator (ANT) is a mitochondrial bi-functional protein, which catalyzes the exchange of ADP and ATP ... The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells. ... The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells. International ...
Mitochondrial ADP/ATP carrier 1 (AAC1); ADP/ATP translocase 1; adenine nucleotide translocator 1 (ANT1); adPEO, Sengers ... Adenine nucleotide transporter, ANT, or ATP:ADP carrier AAC1 (one of three paralogues). Transports heme and heme precursor ... Adenine nucleotide (ATP, ADP) carrier, ANT1; BRITTLE-1. Present in both mitochondria and plastids (Haferkamp and Schmitz-Esser ... The Endoplasmic Reticular Adenine Nucleotide Transporter, ER-ANT1 (probable ATP:ADP exchanger; Leroch et al., 2008) ...
... myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. Nat ... 3). Open image in new window. Fig. 3. Contents of the TarGo database. a The user can find the knock out (KO) target gene using ... 3a).. We performed gene selection using this system by predicting diabetes and obesity-related genes in mice. Six MP terms for ... 3.. Guan Y, Gorenshteyn D, Burmeister M, Wong AK, Schimenti JC, Handel MA, Bult CJ, Hibbs MA, Troyanskaya OG. Tissue-specific ...
Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT). Sihem ... Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) ... Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) ... Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) ...
  • On 0, 1, 2, 3, 4, 6 weeks post injection, frequencies of splenic Tfh cells were determined by flow cytometric analysis, productions of IL-21 and anti-adenine nucleotide translocator(ANT) autoantibody were detected by enzyme-linked immunosorbent assay. (biomedcentral.com)
  • Anti-β1-adrenergic receptor autoantibodies, anti-adenine nucleotide translocator(ANT) autoantibodies and anti-cardiac myosin autoantibodies were common seen in VMC and DCM patients, suggesting the existence of abnormal humoral autoimmune responses in VMC. (biomedcentral.com)
  • Autosomal dominant progressive external ophthalmoplegia is a human mitochondrial disease associated with the presence Galeterone of multiple deletions in the mtDNA [3], . (fk866.net)
  • Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes. (deepdyve.com)
  • The CGA approach may be limited because of probe selection in the Affymetrix Styl array.Among 498 SNPs associated with candidate genes, only 9 were located within exons {CYPJA2, ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2), EPHX1 [epoxide hydrolase 1, microsomal (xenobiotic)], EPHX2, CYP26B1, GSTM3 (glutathione S-transferase mu 3 (brain)], and CYP4B11 and 87 were located within introns. (thefreedictionary.com)
  • Most TCDD effects are mediated by its binding to the awl hydrocarbon receptor (AhR), leading to AhR nuclear translocation, heterodimerization with aryl hydrocarbon receptor nuclear translocator (ARNT), and binding to xenobiotic responsive elements present in the promoters of target genes (Barouki et al. (thefreedictionary.com)
  • Com a biblioteca de subtração de cDNA foram obtidos cinco genes com aumento de expressão em bananas climatéricas, os quais foram similares à expansina, omega-3-desaturase, taumatina, NADH mitocôndrial e metalotioneína. (usp.br)
  • Using cDNA subtraction Iibrary were obtained five genes with an increase of expression in post-climateric bananas and these sequences were similar to expansin, omega-3-desaturase, thaumatin, NADH mithocondrial and methalotionein. (usp.br)
  • Electrons (e − ) from carbon oxidations are transferred via NADH (nicotinamide adenine dinucleotide) into OXPHOS complex I, which is embedded in the lipid bilayer of the mitochondrial inner membrane (IMM), then transported to coenzyme Q (Q). Some electrons from organic‐acid oxidations are transferred, via other flavin‐containing enzyme complexes directly to CoQ. (els.net)
  • Poly(ADP-ribose) polymerases are a family of DNA-dependent nuclear enzymes catalyzing the transfer of ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide to a variety of target proteins. (cdc.gov)
  • The objective of this study was to identify single-nucleotide polymorphisms using a bovine chromosome 14 high-density SNP panel after accounting for the effect of DGAT1. (biomedsearch.com)
  • However, molecular mechanisms underlying the curious dependence of some cancer cells, which contain multiple genomic, genetic, and epigenetic abnormalities, on a single oncogenic molecule (the phenomenon of "oncogene addiction") are incompletely understood ( 3 - 5 ). (mcponline.org)
  • The aim of this research was to determine the sub-cellular location and hence provide information about possible functions of all the putative 3-ketoacyl-CoA thiolases (KAT) and acetoacetyl-CoA thiolases (ACAT) in Arabidopsis. (deepdyve.com)
  • Although Pxa1/2p has been proposed to transport acyl-CoAs of different chain lengths [ 8 , 13 ], medium chain free (non-esterified) fatty acids are also imported into yeast peroxisomes via a parallel, ABC-independent route which requires the peroxisomal acyl-CoA synthetase (ACS), Faa2p and the adenine nucleotide translocator, Ant1p [ 8 , 14 , 15 ]. (biochemsoctrans.org)
  • 3. The method of claim 1, wherein said applying said composition to said sample inhibits keratinocyte proliferation within said sample. (freepatentsonline.com)
  • Here, we investigated the balance between mitochondrial fusion and fission in the substantia nigra of a non-human primate model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD. (bvsalud.org)
  • In the present study, we investigated whether β-Lapachone (β-LAP), a natural naphthoquinone compound isolated from the lapacho tree (Tabebuia avellanedae), elicits neuroprotective effects in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease mouse model. (bvsalud.org)
  • The pyruvate mimetic 3-bromopyruvate (3-BP) is generally presented as an inhibitor of glycolysis and has shown remarkable efficacy in not only preventing tumor growth, but even eradicating existant tumors in animal studies. (springer.com)
  • The cytotoxicity of 3-BP is less due to pyruvate mimicry than to alkylation of, e.g., key thiols. (springer.com)
  • 1-3 Both hyperthyroidism and hypothyroidism produce changes in cardiac contractility, myocardial oxygen consumption, cardiac output, blood pressure, and systemic vascular resistance (SVR). (ahajournals.org)
  • 3. Bova S, Cargnelli G, D'Amato E, Forti S, Yang Q, Trevisi L, Debetto P, Cima L, Luciani S, Padrini R (1997) Calcium-antagonist effect of norbormide on isolated perfused heart and cardiac myocytes of guinea-pig: a comparison with verapamil. (unipd.it)
  • da Silva AP Pereira, El-Bacha T, Kyaw N, dos Santos RS, da-Silva WS, Almeida FC, Da Poian AT, Galina A (2009) Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate. (springer.com)