Adenine Nucleotide Translocator 1: A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).Mitochondrial ADP, ATP Translocases: A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization.Adenine Nucleotide Translocator 2: A subtype of mitochondrial ADP, ATP translocase found primarily in FIBROBLASTS.Atractyloside: A glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEPIS. Toxicity is due to inhibition of ADENINE NUCLEOTIDE TRANSLOCASE.Bongkrekic Acid: An antibiotic produced by Pseudomonas cocovenenans. It is an inhibitor of MITOCHONDRIAL ADP, ATP TRANSLOCASES. Specifically, it blocks adenine nucleotide efflux from mitochondria by enhancing membrane binding.Adenine NucleotidesAdenine Nucleotide Translocator 3: A subtype of mitochondrial ADP, ATP translocase found primarily in the LIVER.Oxidative Phosphorylation: Electron transfer through the cytochrome system liberating free energy which is transformed into high-energy phosphate bonds.Mitochondria: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)Mitochondria, Liver: Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)Nucleotidyltransferases: A class of enzymes that transfers nucleotidyl residues. EC 2.7.7.Intracellular Membranes: Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Voltage-Dependent Anion Channels: A family of voltage-gated eukaryotic porins that form aqueous channels. They play an essential role in mitochondrial CELL MEMBRANE PERMEABILITY, are often regulated by BCL-2 PROTO-ONCOGENE PROTEINS, and have been implicated in APOPTOSIS.Mitochondrial Membrane Transport Proteins: Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.Mitochondrial Swelling: An increase in MITOCHONDRIAL VOLUME due to an influx of fluid; it occurs in hypotonic solutions due to osmotic pressure and in isotonic solutions as a result of altered permeability of the membranes of respiring mitochondria.Mitochondria, Heart: The mitochondria of the myocardium.Adenine: A purine base and a fundamental unit of ADENINE NUCLEOTIDES.Oxygen Consumption: The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)Cyclophilins: A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-Membrane Potential, Mitochondrial: The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.Uncoupling Agents: Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.Cell Respiration: The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell.Permeability: Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.Aryl Hydrocarbon Receptor Nuclear Translocator: Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with DIOXIN RECEPTOR. The complex binds xenobiotic regulatory elements and activates transcription of a variety of genes including UDP GLUCURONOSYLTRANSFERASE. AhR nuclear translocator is also a subunit of HYPOXIA-INDUCIBLE FACTOR 1.Proto-Oncogene Proteins c-bcl-2: Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.Mitochondrial Proteins: Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.Nucleotides: The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Kinetics: The rate dynamics in chemical or physical systems.DNA, Mitochondrial: Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Receptors, GABA: Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.Receptors, Aryl Hydrocarbon: Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.Energy Metabolism: The chemical reactions involved in the production and utilization of various forms of energy in cells.Purine Nucleotides: Purines attached to a RIBOSE and a phosphate that can polymerize to form DNA and RNA.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Guanine NucleotidesAdenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Hypoxanthines: Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.
(1/10) Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells.

Mitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce apoptosis. Nothing is known, however, about the apoptotic activity of ANT3. We have transfected HeLa cells with the three human ANT isoforms to compare their potential as inducers of apoptosis. Transient overexpression of ANT3 resulted, like ANT1, in apoptosis as shown by an increase in the sub-G1 fraction, annexin V staining, low DeltaPsi(m), and activation of caspases 9 and 3. Moreover, the apoptosis produced by ANT3 was inhibited by bongkrekic acid and by cyclosporin A. The pro-apoptotic activities of the ANT1 and ANT3 isoforms contrast with the lack of apoptotic activity of ANT2. This finding may help to identify the specific factors associated with the pro-apoptotic activities of ANT isoforms.  (+info)

(2/10) Effects of extramitochondrial ADP on permeability transition of mouse liver mitochondria.

Carboxyatractylate (CAT) and atractylate inhibit the mitochondrial adenine nucleotide translocator (ANT) and stimulate the opening of permeability transition pore (PTP). Following pretreatment of mouse liver mitochondria with 5 microM CAT and 75 microM Ca2+, the activity of PTP increased, but addition of 2 mM ADP inhibited the swelling of mitochondria. Extramitochondrial Ca2+ concentration measured with Calcium-Green 5N evidenced that 2 mM ADP did not remarkably decrease the free Ca2+ but the release of Ca2+ from loaded mitochondria was stopped effectively after addition of 2 mM ADP. CAT caused a remarkable decrease of the maximum amount of calcium ions, which can be accumulated by mitochondria. Addition of 2 mM ADP after 5 microM CAT did not change the respiration, but increased the mitochondrial capacity for Ca2+ at more than five times. Bongkrekic acid (BA) had a biphasic effect on PT. In the first minutes 5 microM BA increased the stability of mitochondrial membrane followed by a pronounced opening of PTP too. BA abolished the action about of 1 mM ADP, but was not able to induce swelling of mitochondria in the presence of 2 mM ADP. We conclude that the outer side of inner mitochondrial membrane has a low affinity sensor for ADP, modifying the activity of PTP. The pathophysiological importance of this process could be an endogenous prevention of PT at conditions of energetic depression.  (+info)

(3/10) Dinitrophenol-induced mitochondrial uncoupling in vivo triggers respiratory adaptation in HepG2 cells.

Here, we show that 3 days of mitochondrial uncoupling, induced by low concentrations of dinitrophenol (10 and 50 microM) in cultured human HepG2 cells, triggers cellular metabolic adaptation towards oxidative metabolism. Chronic respiratory uncoupling of HepG2 cells induced an increase in cellular oxygen consumption, oxidative capacity and cytochrome c oxidase activity. This was associated with an upregulation of COXIV and ANT3 gene expression, two nuclear genes that encode mitochondrial proteins involved in oxidative phosphorylation. Glucose consumption, lactate and pyruvate production and growth rate were unaffected, indicating that metabolic adaptation of HepG2 cells undergoing chronic respiratory uncoupling allows continuous and efficient mitochondrial ATP production without the need to increase glycolytic activity. In contrast, 3 days of dinitrophenol treatment did not change the oxidative capacity of human 143B.TK(-) cells, but it increased glucose consumption, lactate and pyruvate production. Despite a large increase in glycolytic metabolism, the growth rate of 143B.TK(-) cells was significantly reduced by dinitrophenol-induced mitochondrial uncoupling. We propose that chronic respiratory uncoupling may constitute an internal bioenergetic signal, which would initiate a coordinated increase in nuclear respiratory gene expression, which ultimately drives mitochondrial metabolic adaptation within cells.  (+info)

(4/10) Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats.

We proposed that inhibition of mitochondrial adenine nucleotide translocator (ANT) by long chain acyl-CoA (LCAC) underlies the mechanism associating obesity and type 2 diabetes. Here we test that after long-term exposure to a high-fat diet (HFD): (i) there is no adaptation of the mitochondrial compartment that would hinder such ANT inhibition, and (ii) ANT has significant control of the relevant aspects of oxidative phosphorylation. After 7 weeks, HFD induced a 24+/-6% increase in hepatic LCAC concentration and accumulation of the oxidative stress marker N(epsilon)-(carboxymethyl)lysine. HFD did not significantly affect mitochondrial copy number, oxygen uptake, membrane potential (Deltapsi), ADP/O ratio, and the content of coenzyme Q(9), cytochromes b and a+a(3). Modular kinetic analysis showed that the kinetics of substrate oxidation, phosphorylation, proton leak, ATP-production and ATP-consumption were not influenced significantly. After HFD-feeding ANT exerted considerable control over oxygen uptake (control coefficient C=0.14) and phosphorylation fluxes (C=0.15), extra- (C=0.23) and intramitochondrial (C=-0.56) ATP/ADP ratios, and Deltapsi (C=-0.11). We conclude that although HFD induces accumulation of LCAC and N(epsilon)-(carboxymethyl)lysine, oxidative phosphorylation does not adapt to these metabolic challenges. Furthermore, ANT retains control of fluxes and intermediates, making inhibition of this enzyme a more probable link between obesity and type 2 diabetes.  (+info)

(5/10) Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells.

Mitochondrial adenine nucleotide translocase (ANT) is believed to be a component or a regulatory component of the mitochondrial permeability transition pore (mtPTP), which controls mitochondrial permeability transition during apoptosis. However, the role of ANT in apoptosis is still uncertain, because hepatocytes isolated from ANT knockout and wild-type mice are equally sensitive to TNF- and Fas-induced apoptosis. In a screen for genes required for tumor necrosis factor alpha (TNF-alpha)-induced apoptosis in MCF-7 human breast cancer cells using retrovirus insertion-mediated random mutagenesis, we discovered that the ANT3 gene is involved in TNF-alpha-induced cell death in MCF-7 cells. We further found that ANT3 is selectively required for TNF- and oxidative stress-induced cell death in MCF-7 cells, but it is dispensable for cell death induced by several other inducers. This data supplements previous data obtained from ANT knockout studies, indicating that ANT is involved in some apoptotic processes. We found that the resistance to TNF-alpha-induced apoptosis observed in ANT3 mutant (ANT3(mut)) cells is associated with a deficiency in the regulation of the mitochondrial membrane potential and cytochrome c release. It is not related to intracellular ATP levels or survival pathways, supporting a previous model in which ANT regulates mtPTP. Our study provides genetic evidence supporting a role of ANT in apoptosis and suggests that the involvement of ANT in cell death is cell type- and stimulus-dependent.  (+info)

(6/10) Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells.

 (+info)

(7/10) Overexpression of GAP-43 reveals unexpected properties of hippocampal mossy fibers.

 (+info)

(8/10) Full-length enriched cDNA library construction from tissues related to energy metabolism in pigs.

 (+info)

*  SLC25A6
Jang JY, Lee CE (2003). "Mitochondrial adenine nucleotide translocator 3 is regulated by IL-4 and IFN-gamma via STAT-dependent ... Adenine nucleotide translocator Solute carrier family GRCh38: Ensembl release 89: ENSG00000169100 - Ensembl, May 2017 "Human ... 2001). "A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family". Neurology. 57 (12): 2295-8. ... 2002). "A novel D104G mutation in the adenine nucleotide translocator 1 gene in autosomal dominant progressive external ...
*  List of MeSH codes (D12.776)
... adenine nucleotide translocator 1 MeSH D12.776.575.750.500.200 - adenine nucleotide translocator 2 MeSH D12.776.575.750.500.300 ... adenine nucleotide translocator 3 MeSH D12.776.580.210.175.325 - groes protein MeSH D12.776.580.210.180.325 - groel protein ... actin-related protein 3 MeSH D12.776.220.525.475.100 - myosin heavy chains MeSH D12.776.220.525.475.200 - myosin light chains ... type 3 MeSH D12.776.624.664.700.130 - muts homolog 2 protein MeSH D12.776.624.664.700.148 - myeloid-lymphoid leukemia protein ...
*  Y linkage
... adenine nucleotide translocator-3 on the Y), SOX21 (known to cause baldness), AZF2 (azoospermia factor 2), BPY2 (basic protein ... interleukin-3 receptor), SRY (sex-determining region), TDF (testis determining factor), ZFY (zinc finger protein), PRKY ( ...
*  List of MeSH codes (D12.776.543)
... adenine nucleotide translocator 1 MeSH D12.776.543.585.450.162.235.200 -- adenine nucleotide translocator 2 MeSH D12.776. ... adenine nucleotide translocator 1 MeSH D12.776.543.585.625.875.500.200 -- adenine nucleotide translocator 2 MeSH D12.776. ... 543.585.625.875.500.300 -- adenine nucleotide translocator 3 MeSH D12.776.543.585.750.100 -- aryl hydrocarbon receptor nuclear ... adenine nucleotide translocator 3 MeSH D12.776.543.585.450.162.276 -- potassium-hydrogen antiporters MeSH D12.776.543.585. ...
*  Adenine nucleotide translocator
... 1 at the US National Library of Medicine Medical Subject Headings (MeSH) Adenine Nucleotide ... Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocator, exports ATP from the mitochondrial matrix and ... Translocator 2 at the US National Library of Medicine Medical Subject Headings (MeSH) Adenine Nucleotide Translocator 3 at the ... "Role of adenine nucleotide translocator 1 in mtDNA maintenance". Science. 289 (5480): 782-785. doi:10.1126/science.289.5480.782 ...
*  SLC25A5
Ku DH, Kagan J, Chen ST, Chang CD, Baserga R, Wurzel J (Sep 1990). "The human fibroblast adenine nucleotide translocator gene. ... The product of this gene, adenine nucleotide translocator 2 (ANT2), functions as a major constituent of the mitochondrial ... Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 is a protein that in humans is ... adenine nucleotide translocator), member 5". Retrieved 2013-09-18. Chevrollier A, Loiseau D, Reynier P, Stepien G (Jun 2011). " ...
*  List of MeSH codes (D12.776.157)
... adenine nucleotide translocator 1 MeSH D12.776.157.530.625.875.500.200 -- adenine nucleotide translocator 2 MeSH D12.776. ... 157.530.625.875.500.300 -- adenine nucleotide translocator 3 MeSH D12.776.157.530.750.100 -- aryl hydrocarbon receptor nuclear ... nucleotide transport proteins MeSH D12.776.157.530.625.875.500 -- mitochondrial adp, atp translocases MeSH D12.776.157.530. ... translocator MeSH D12.776.157.530.750.200 -- cellular apoptosis susceptibility protein MeSH D12.776.157.530.750.500 -- ...
*  SLC25A31
"Entrez Gene: SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31". Gallerne C ... "Computational analysis of the transcriptional regulation of the adenine nucleotide translocator isoform 4 gene and its role in ... "The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells". The International ... Chevrollier A, Loiseau D, Reynier P, Stepien G (Jun 2011). "Adenine nucleotide translocase 2 is a key mitochondrial protein in ...
*  Boris Kholodenko
"The role of adenine nucleotide translocator in regulation of oxidative phosphorylation in heart mitochondria". FEBS Letters. ... "Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat ... 3: 145-154. doi:10.1142/s0218339095000149. Cascante, M.; Melendez-Hevia, E.; Kholodenko, B.N.; Sicilia, J.; Kacser, H. (1995 ... doi:10.1016/s0014-5793(99)01058-3. Kholodenko, B.N., Demin, O.V.; Moehren, G.; Hoek, J.B. (1999). "Quantification of short-term ...
*  AGK (gene)
AGK also has an implicated role in the assembly of the adenine nucleotide translocator in the inner mitochondrial membrane. ... 50 (3): 363-71. doi:10.1007/s00592-012-0422-1. PMID 22864860. Human AGK genome location and AGK gene details page in the UCSC ... ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate. The enzyme is involved in the more general pathway of ... In the proliferation of prostate cancer, AGK interacts with and regulates PC-3 prostate cancer cells markedly increased ...
*  Membrane transport protein
Adenine nucleotide translocator (ANT) 2.B: Nonribosomally synthesized porters, such as The Nigericin (Nigericin) Family The ... such as rhodopsin The group translocators provide a special mechanism for the phosphorylation of sugars as they are transported ... 38 (3): 305-315. doi:10.1016/j.tips.2016.11.008. ISSN 1873-3735. PMID 27939446. Sadava, David, et al. Life, the Science of ... 38 (3): 305-315. doi:10.1016/j.tips.2016.11.008. ISSN 1873-3735. PMID 27939446. Sherwood, Lauralee. 7th Edition. Human ...
*  BCL2L13
Kim JY, So KJ, Lee S, Park JH (Sep 2012). "Bcl-rambo induces apoptosis via interaction with the adenine nucleotide translocator ... Bcl-rambo mediates apoptosis by associating with adenine nucleotide translocator (ANT), a component of the mitochondrial ... 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. Banga S, Gao P, Shen X, Fiscus V, Zong WX, Chen L, Luo ZQ (Mar ... 534 (1-3): 61-8. doi:10.1016/S0014-5793(02)03778-X. PMID 12527362. Human BCL2L13 genome location and BCL2L13 gene details page ...
*  Bcl-2-associated X protein
"Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science. 281 (5385): 2027-31. ... 2 (3): 238-40. doi:10.4161/auto.2730. PMID 16874066. [permanent dead link] Weng C, Li Y, Xu D, Shi Y, Tang H (March 2005). " ... Nomura M, Shimizu S, Sugiyama T, Narita M, Ito T, Matsuda H, Tsujimoto Y (2003). "14-3-3 Interacts directly with and negatively ... 278 (3): 2058-65. doi:10.1074/jbc.M207880200. PMID 12426317. Hoppins, Suzanne; Edlich, Frank; Cleland, Megan M.; Banerjee, ...
*  CYC1
2001). "Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral ... 1988). "Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1". Nucleic Acids Res. 16 (8): 3577. doi: ... Yuan J, Murrell GA, Trickett A, Wang MX (2003). "Involvement of cytochrome c release and caspase-3 activation in the oxidative ... doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Valnot I, Kassis J, Chretien D, et al. (1999). "A mitochondrial cytochrome b ...
*  Thermogenin
UCP1 is related to other mitochondrial metabolite transporters such as the adenine nucleotide translocator, a proton channel in ... UCP1 is activated in the brown fat cell by fatty acids and inhibited by nucleotides. Fatty acids cause the following signaling ... overriding the inhibition caused by purine nucleotides (GDP and ADP). During the termination of thermogenesis, thermogenin is ... 44 (3): 373-6. doi:10.1007/s001250051629. PMID 11317671. Nibbelink M, Moulin K, Arnaud E, Duval C, Pénicaud L, Casteilla L (Dec ...
*  SLC25A4
ADP/ATP translocase 1 is an enzyme that in humans is encoded by the SLC25A4 gene or adenine nucleotide translocator, ANT. ... "Entrez Gene: SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4". Marzo I, ... "Deficiency of the adenine nucleotide translocator in muscle of a patient with myopathy and lactic acidosis: a new mitochondrial ... "A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed ...
*  TXN2
... thiols in the mitochondrial permeability transition pore component adenine nucleotide translocator (ANT). Overexpression of ... "Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer". Cancer Research. ... 443 (3): 821-7. doi:10.1016/j.bbrc.2013.12.050. PMID 24342608. Wang Z, Zhang H, Li XF, Le XC (2007). "Study of interactions ... Two mRNA transcripts of the TXN2 gene differ by ~330 bp in the length of the 3′-untranslated region, and both are believed to ...
*  Apoptosome
... the inner membrane protein adenine nucleotide translocator (AdNT) and the matrix protein cyclophilin D (CyD) (12). This pore ... It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. ... A short linker and nucleotide binding a/b domains (NBD) that contain conserved Walker boxes A (p-loop 155-161) and B (239-243) ... Another model proposes that Apaf-1 is organized in an extended fashion such that both the N-terminal CARD and the nucleotide ...
*  Mitochondrial carrier
SLC25A25 adenine nucleotide - SLC25A4, SLC25A5, SLC25A6, SLC25A31 dicarboxylate - SLC25A10 oxoglutarate - SLC25A11 glutamate - ... "Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential". Journal ... nucleotides, amino acids, keto acids and cofactors across the membrane. Such proteins include: ADP/ATP carrier protein (ADP-ATP ... nucleotides, inorganic ions and co-factors through the mitochondrial inner membrane. The transporters consist of six ...
*  Mitochondrial permeability transition pore
Further hypothesis by Halestrap´s group convincingly suggested the MPT was formed by the inner membrane Adenine Nucleotide ... "The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore". Nature. 427 (6973): 461-465. doi ... "The nature of the calcium ion efflux induced in rat liver mitochondria by the oxidation of endogenous nicotinamide nucleotides ... "Regulation of the Inner Membrane Mitochondrial Permeability Transition by the Outer Membrane Translocator Protein (Peripheral ...
Anti-Adenine Nucleotide Translocator 2 antibody (ab118125)  Anti-Adenine Nucleotide Translocator 2 antibody (ab118125)
Rabbit polyclonal Adenine Nucleotide Translocator 2 antibody validated for WB, IP and tested in Human. With 2 independent ... Anti-Adenine Nucleotide Translocator 2 antibody. See all Adenine Nucleotide Translocator 2 primary antibodies. ... Immunoprecipitation of Adenine Nucleotide Translocator 2 transfected lysate using ab118125 and Protein A Magnetic Bead, and ... Recombinant full length protein, corresponding to amino acids 1-298 of Human Adenine Nucleotide Translocator 2 (NP_001143.2). ...
more infohttp://www.abcam.com/adenine-nucleotide-translocator-2-antibody-ab118125.html
Adenine Nucleotide Translocator 1
     Summary Report | CureHunter  Adenine Nucleotide Translocator 1 Summary Report | CureHunter
Adenine Nucleotide Translocator 1: A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM ... Adenine Nucleotide Translocator 1. Subscribe to New Research on Adenine Nucleotide Translocator 1 ... ANT-1 Transport Protein; ANT1 Transport Protein; Adenine Nucleotide Carrier Protein; Adenine Nucleotide Translocator, Muscle ... Nucleotide Transport Proteins*ATP Translocases Mitochondrial ADP: 95*Adenine Nucleotide Translocator 1: 14 ...
more infohttp://www.curehunter.com/public/keywordSummaryD033741-Adenine-Nucleotide-Translocator-1.do
Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) |...  Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) |...
Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT). Sihem ... Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) ... Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) ... Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) ...
more infohttp://circ.ahajournals.org/content/114/Suppl_18/II_244.5
Adenine nucleotide translocator synonyms, Adenine nucleotide translocator antonyms - FreeThesaurus.com  Adenine nucleotide translocator synonyms, Adenine nucleotide translocator antonyms - FreeThesaurus.com
Antonyms for Adenine nucleotide translocator. 1 synonym for adenine: A. What are synonyms for Adenine nucleotide translocator? ... Synonyms for Adenine nucleotide translocator in Free Thesaurus. ... Related to Adenine nucleotide translocator: adenine nucleotide ... Adenine nucleotide translocator synonyms, Adenine nucleotide translocator antonyms - FreeThesaurus.com https://www. ... adenine. (redirected from Adenine nucleotide translocator). Also found in: Dictionary, Medical, Acronyms, Encyclopedia, ...
more infohttps://www.freethesaurus.com/Adenine+nucleotide+translocator
Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility...  Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility...
Stepien G, Torroni A, Chung AB, Hodge JA, Wallace DC: Differential expression of adenine nucleotide translocator isoforms in ... Adenine nucleotide translocase-2 (ANT2), one of the four adenine nucleotide translocase isoforms expressed in humans, is ... Adenine nucleotide translocase, a protein located in the inner mitochondrial membrane, catalyzes the exchange of mitochondrial ... Jang JY, Jeon YK, Kim CW: Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells ...
more infohttps://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-9-262
AAC3 - ADP,ATP carrier protein 3, mitochondrial precursor - Arabidopsis thaliana (Mouse-ear cress) - AAC3 gene & protein  AAC3 - ADP,ATP carrier protein 3, mitochondrial precursor - Arabidopsis thaliana (Mouse-ear cress) - AAC3 gene & protein
Adenine nucleotide translocator 3. Short name: ANT 3. ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_ ... purine nucleotide transport Source: TAIRInferred from direct assayi*. "Functional integration of mitochondrial and ... Nucleotide carrier signature motifBy similarity. Manual assertion inferred from sequence similarity toi ... ADP,ATP carrier protein 3, mitochondrialAdd BLAST. 310. Proteomic databases. PaxDb, a database of protein abundance averages ...
more infohttps://www.uniprot.org/uniprot/O49447
SLC25A6 Antibody (PA5-70402)
                
                
		        
	  SLC25A6 Antibody (PA5-70402)
Protein Aliases: AAC3; adenine nucleotide translocator 2; Adenine nucleotide translocator 3; adenine nucleotide translocator 3 ... adenine nucleotide translocator), member 6; Solute carrier family 25 member 6; solute carrier family 25, member A6 ... translation protein targeting to mitochondrion apoptotic process adenine transport ADP transport ATP transport active induction ... structural constituent of ribosome ATP:ADP antiporter activity protein binding adenine transmembrane transporter activity ...
more infohttps://www.thermofisher.com/antibody/product/SLC25A6-Antibody-Polyclonal/PA5-70402
SLC25A6P1 Gene - GeneCards | SLC25A6P1 Pseudogene  SLC25A6P1 Gene - GeneCards | SLC25A6P1 Pseudogene
Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6, Pseudogene 1 2 3 ... Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6 Pseudogene 3 ... Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 5-Like 2 ... The GeneCards human gene database index: 1 2 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC25A6P1
SLC25A6 - Wikipedia  SLC25A6 - Wikipedia
Jang JY, Lee CE (2003). "Mitochondrial adenine nucleotide translocator 3 is regulated by IL-4 and IFN-gamma via STAT-dependent ... Adenine nucleotide translocator Solute carrier family GRCh38: Ensembl release 89: ENSG00000169100 - Ensembl, May 2017 "Human ... 2001). "A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family". Neurology. 57 (12): 2295-8. ... 2002). "A novel D104G mutation in the adenine nucleotide translocator 1 gene in autosomal dominant progressive external ...
more infohttps://en.wikipedia.org/wiki/SLC25A6
A transcriptomic approach to study the effect of long-term starvation and diet composition on the expression of mitochondrial...  A transcriptomic approach to study the effect of long-term starvation and diet composition on the expression of mitochondrial...
... and ADP/ATP translocase 3 (SLC25A6) in the liver, and cytochrome c oxidase subunit 5B isoform 1 (COX5B1) in the liver and the ... Differential expression of adenine nucleotide translocator isoforms in mammalian tissues and during muscle cell differentiation ... Human cytomegalovirus miR-UL36-5p inhibits apoptosis via downregulation of adenine nucleotide translocator 3 in cultured cells ... Zamora M, Granell M, Mampel T, Viñas O. Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured ...
more infohttps://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-4148-x
ADP/ATP translocase 3 (P12236) | InterPro | EMBL-EBI  ADP/ATP translocase 3 (P12236) | InterPro | EMBL-EBI
Adenine nucleotide translocator 1 (IPR002113). Homologous superfamilies. * Homologous superfamily. 1 50 100 150 200 250 298 ...
more infohttp://www.ebi.ac.uk/interpro/protein/P12236
Anti-Adenine Nucleotide Translocator 2/ANT 2 antibody (ab221956) | Abcam  Anti-Adenine Nucleotide Translocator 2/ANT 2 antibody (ab221956) | Abcam
Rabbit polyclonal Adenine Nucleotide Translocator 2/ANT 2 antibody. Validated in WB, IHC and tested in Human. Independently ... Anti-Adenine Nucleotide Translocator 2/ANT 2 antibody. See all Adenine Nucleotide Translocator 2/ANT 2 primary antibodies. ... All lanes : Anti-Adenine Nucleotide Translocator 2/ANT 2 antibody (ab221956) at 1/100 dilution. Lane 1 : RT-4 cell lysate. Lane ... This product Rabbit Anti-Adenine Nucleotide Translocator 2/ANT 2 antibody (ab221956) IHC-P, WB ...
more infohttps://www.abcam.com/adenine-nucleotide-translocator-2ant-2-antibody-ab221956.html
List of MeSH codes (D12.776) - Wikipedia  List of MeSH codes (D12.776) - Wikipedia
... adenine nucleotide translocator 1 MeSH D12.776.575.750.500.200 - adenine nucleotide translocator 2 MeSH D12.776.575.750.500.300 ... adenine nucleotide translocator 3 MeSH D12.776.580.210.175.325 - groes protein MeSH D12.776.580.210.180.325 - groel protein ... actin-related protein 3 MeSH D12.776.220.525.475.100 - myosin heavy chains MeSH D12.776.220.525.475.200 - myosin light chains ... type 3 MeSH D12.776.624.664.700.130 - muts homolog 2 protein MeSH D12.776.624.664.700.148 - myeloid-lymphoid leukemia protein ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
Viruses  | Free Full-Text | Innate Immunity to H5N1 Influenza Viruses in Humans | HTML  Viruses | Free Full-Text | Innate Immunity to H5N1 Influenza Viruses in Humans | HTML
They showed that PB1-F2 interacts with the adenine nucleotide translocator 3 (ANT3) and the membrane voltage-dependent anion ... or the Nucleotide Oligomerization Domain (NOD)-like receptors (NLRs) (reviewed by [22,23]). ... In Figure 3 we show that while the desired outcome of infection is viral clearance, in the case of H5N1 IAV infections the ... 3-21. [Google Scholar]. *Tong, S.; Li, Y.; Rivailler, P.; Conrardy, C.; Castillo, D.A.; Chen, L.M.; Recuenco, S.; Ellison, J.A ...
more infohttp://mdpi.com/1999-4915/4/12/3363/htm
3-bromopyruvate: Targets and outcomes | SpringerLink  3-bromopyruvate: Targets and outcomes | SpringerLink
The pyruvate mimetic 3-bromopyruvate (3-BP) is generally presented as an inhibitor of glycolysis and has shown remarkable ... Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition ... 3-bromopyruvate Cancer Energy metabolism Chemotherapy toxicity This is a preview of subscription content, log in to check ... The cytotoxicity of 3-BP is less due to pyruvate mimicry than to alkylation of, e.g., key thiols. Alkylation of DNA/RNA has not ...
more infohttps://link.springer.com/article/10.1007%2Fs10863-012-9419-2
Measurement of the energy-generating capacity of human muscle mitochondria: diagnostic procedure and application to human...  Measurement of the energy-generating capacity of human muscle mitochondria: diagnostic procedure and application to human...
Deficiency of the adenine nucleotide translocator in muscle of a patient with myopathy and lactic acidosis: a new mitochondrial ... The adenine nucleotide translocator (ANT) transports ATP out of the mitochondrion. Deficiencies have been found in all OXPHOS ... adenine nucleotide translocator; mtDNA, mitochondrial DNA; CCCP, carbonyl cyanide 3-chlorophenyl hydrazone; CS, citrate ... 3.) De Meirleir L. Defects of pyruvate metabolism and the Krebs cycle. J Child Neurol 2002;17:26-33. (4.) Triepels RH, Hanson ...
more infohttps://www.thefreelibrary.com/Measurement+of+the+energy-generating+capacity+of+human+muscle+...-a0209353130
Biology-Online • View topic - Traits Question  Biology-Online • View topic - Traits Question
ANT3Y (adenine nucleotide translocator-3 on the Y), * AZF2 (azoospermia factor 2), * BPY2 (basic protein on the Y chromosome), ... IL3RAY (interleukin-3 receptor), * SRY (sex-determining region), * TDF (testis determining factor), * ZFY (zinc finger protein ...
more infohttp://www.biology-online.org/biology-forum/post-7663.html
SLC25A6 Antibody (monoclonal) (M01) - Mouse monoclonal antibody raised against a partial recombinant SLC25A6.  WB, E - Buy Now!...  SLC25A6 Antibody (monoclonal) (M01) - Mouse monoclonal antibody raised against a partial recombinant SLC25A6. WB, E - Buy Now!...
Adenine nucleotide translocator 3, ANT 3, Solute carrier family 25 member 6, ADP/ATP translocase 3, N-terminally processed, ... PMID 19111545.Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 ... PMID 17220478.IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis. ... PMID 19669810.Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human ...
more infohttp://www.abgent.com/products/AT3913a-SLC25A6-Antibody-monoclonal-M01
Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes in Arabidopsis thaliana are...  Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes in Arabidopsis thaliana are...
"Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes in Arabidopsis thaliana are ... The adenine nucleotide translocator of higher plants is synthesized as a large precursor that is processed upon import into ... Two genes encode the adenine nucleotide translocator of maize mitochondria. Isolation, characterisation and expression of the ... Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes... Carrie, Chris; Murcha, ...
more infohttps://www.deepdyve.com/lp/springer_journal/nine-3-ketoacyl-coa-thiolases-kats-and-acetoacetyl-coa-thiolases-acats-CQU74ee4Bx
Browse our SLC25A6 ELISA Kits  Browse our SLC25A6 ELISA Kits
... adenine nucleotide translocator 2 , adenine nucleotide translocator 3 (liver) , solute carrier family 25, member A6 , ... Adenine Nucleotide Translocator), Member 5 ELISA Kits * Solute Carrier Family 25 (Mitochondrial Carrier, Adenine Nucleotide ... Solute Carrier Family 25 (Mitochondrial Carrier, Adenine Nucleotide Translocator), Member 6 (SLC25A6) ELISA Kits. SLC25A6 is a ... Cow (Bovine) Solute Carrier Family 25 (Mitochondrial Carrier, Adenine Nucleotide Translocator), Member 6 (SLC25A6) interaction ...
more infohttps://www.antibodies-online.com/abstract/Solute+Carrier+Family+25+
  • This process activates caspase-8 and -10, which can then directly activate effector caspases (caspase-3, -6, and -7) to cause apoptosis. (biomedcentral.com)
  • On 0, 1, 2, 3, 4, 6 weeks post injection, frequencies of splenic Tfh cells were determined by flow cytometric analysis, productions of IL-21 and anti-adenine nucleotide translocator(ANT) autoantibody were detected by enzyme-linked immunosorbent assay. (biomedcentral.com)
  • Anti-β1-adrenergic receptor autoantibodies, anti-adenine nucleotide translocator(ANT) autoantibodies and anti-cardiac myosin autoantibodies were common seen in VMC and DCM patients, suggesting the existence of abnormal humoral autoimmune responses in VMC. (biomedcentral.com)
  • The lipase converts triacylglycerols into free fatty acids, which activate UCP1, overriding the inhibition caused by purine nucleotides (GDP and ADP). (wikipedia.org)
  • A variety of these substrate carrier proteins, which are involved in energy transfer, have been found in the inner membranes of mitochondria and other eukaryotic organelles such as the peroxisome and facilitate the transport of inorganic ions, nucleotides, amino acids, keto acids and cofactors across the membrane. (wikipedia.org)
  • More research is warranted to better understand the pharmacokinetics of 3-BP, and its potential toxic effects to normal cells, in particular those that are highly ATP-/mitochondrion-dependent. (springer.com)
  • The human mitochondrion contains at least 100 different proteins directly involved in the mitochondrial energy-generating system (MEGS) [3] (1). (thefreelibrary.com)
  • The adenine nucleotide translocator (ANT) transports ATP out of the mitochondrion. (thefreelibrary.com)
  • The pyruvate mimetic 3-bromopyruvate (3-BP) is generally presented as an inhibitor of glycolysis and has shown remarkable efficacy in not only preventing tumor growth, but even eradicating existant tumors in animal studies. (springer.com)
  • The cytotoxicity of 3-BP is less due to pyruvate mimicry than to alkylation of, e.g., key thiols. (springer.com)
  • The aim of this research was to determine the sub-cellular location and hence provide information about possible functions of all the putative 3-ketoacyl-CoA thiolases (KAT) and acetoacetyl-CoA thiolases (ACAT) in Arabidopsis. (deepdyve.com)
  • da Silva AP Pereira, El-Bacha T, Kyaw N, dos Santos RS, da-Silva WS, Almeida FC, Da Poian AT, Galina A (2009) Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate. (springer.com)
  • We here review reported molecular targets of 3-BP and suggest that the very range of possible targets, which pertain to the altered energy metabolism of tumor cells, contributes both to the efficacy and the tumor specificity of the drug. (springer.com)
  • Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes. (deepdyve.com)
  • Deficiencies have been found in all OXPHOS complexes, PDHc, the TCA cycle (3), and ANT. (thefreelibrary.com)
  • In the proliferation of prostate cancer, AGK interacts with and regulates PC-3 prostate cancer cells markedly increased formation and secretion of LPA. (wikipedia.org)
  • We developed a unique set of incubations with 3 carboxyl-[sup.-labeled substrates, in combination with measurement of ATP production, in intact muscle mitochondria that gives maximum information about the MEGS capacity. (thefreelibrary.com)
  • 1-3 Both hyperthyroidism and hypothyroidism produce changes in cardiac contractility, myocardial oxygen consumption, cardiac output, blood pressure, and systemic vascular resistance (SVR). (ahajournals.org)