A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).
A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization.
A subtype of mitochondrial ADP, ATP translocase found primarily in FIBROBLASTS.
A glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEPIS. Toxicity is due to inhibition of ADENINE NUCLEOTIDE TRANSLOCASE.
An antibiotic produced by Pseudomonas cocovenenans. It is an inhibitor of MITOCHONDRIAL ADP, ATP TRANSLOCASES. Specifically, it blocks adenine nucleotide efflux from mitochondria by enhancing membrane binding.
A subtype of mitochondrial ADP, ATP translocase found primarily in the LIVER.
Electron transfer through the cytochrome system liberating free energy which is transformed into high-energy phosphate bonds.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)
A class of enzymes that transfers nucleotidyl residues. EC 2.7.7.
Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.
Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
A family of voltage-gated eukaryotic porins that form aqueous channels. They play an essential role in mitochondrial CELL MEMBRANE PERMEABILITY, are often regulated by BCL-2 PROTO-ONCOGENE PROTEINS, and have been implicated in APOPTOSIS.
Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.
An increase in MITOCHONDRIAL VOLUME due to an influx of fluid; it occurs in hypotonic solutions due to osmotic pressure and in isotonic solutions as a result of altered permeability of the membranes of respiring mitochondria.
The mitochondria of the myocardium.
A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-
The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.
Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.
The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell.
Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.
Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with DIOXIN RECEPTOR. The complex binds xenobiotic regulatory elements and activates transcription of a variety of genes including UDP GLUCURONOSYLTRANSFERASE. AhR nuclear translocator is also a subunit of HYPOXIA-INDUCIBLE FACTOR 1.
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.
The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
The rate dynamics in chemical or physical systems.
Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.
Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.
Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.
The chemical reactions involved in the production and utilization of various forms of energy in cells.
Purines attached to a RIBOSE and a phosphate that can polymerize to form DNA and RNA.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.
Genes bearing close resemblance to known genes at different loci, but rendered non-functional by additions or deletions in structure that prevent normal transcription or translation. When lacking introns and containing a poly-A segment near the downstream end (as a result of reverse copying from processed nuclear RNA into double-stranded DNA), they are called processed genes.
K-Cl cotransporter ubiquitously expressed with higher expression levels in ERYTHROCYTES of ANEMIA, SICKLE CELL. It mediates active potassium and chloride cotransport across the plasma membrane and contributes to cell volume homeostasis
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Na-Cl cotransporter in the convoluted segments of the DISTAL KIDNEY TUBULE. It mediates active reabsorption of sodium and chloride and is inhibited by THIAZIDE DIURETICS.
Databases devoted to knowledge about specific genes and gene products.
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.

Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells. (1/10)

Mitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce apoptosis. Nothing is known, however, about the apoptotic activity of ANT3. We have transfected HeLa cells with the three human ANT isoforms to compare their potential as inducers of apoptosis. Transient overexpression of ANT3 resulted, like ANT1, in apoptosis as shown by an increase in the sub-G1 fraction, annexin V staining, low DeltaPsi(m), and activation of caspases 9 and 3. Moreover, the apoptosis produced by ANT3 was inhibited by bongkrekic acid and by cyclosporin A. The pro-apoptotic activities of the ANT1 and ANT3 isoforms contrast with the lack of apoptotic activity of ANT2. This finding may help to identify the specific factors associated with the pro-apoptotic activities of ANT isoforms.  (+info)

Effects of extramitochondrial ADP on permeability transition of mouse liver mitochondria. (2/10)

Carboxyatractylate (CAT) and atractylate inhibit the mitochondrial adenine nucleotide translocator (ANT) and stimulate the opening of permeability transition pore (PTP). Following pretreatment of mouse liver mitochondria with 5 microM CAT and 75 microM Ca2+, the activity of PTP increased, but addition of 2 mM ADP inhibited the swelling of mitochondria. Extramitochondrial Ca2+ concentration measured with Calcium-Green 5N evidenced that 2 mM ADP did not remarkably decrease the free Ca2+ but the release of Ca2+ from loaded mitochondria was stopped effectively after addition of 2 mM ADP. CAT caused a remarkable decrease of the maximum amount of calcium ions, which can be accumulated by mitochondria. Addition of 2 mM ADP after 5 microM CAT did not change the respiration, but increased the mitochondrial capacity for Ca2+ at more than five times. Bongkrekic acid (BA) had a biphasic effect on PT. In the first minutes 5 microM BA increased the stability of mitochondrial membrane followed by a pronounced opening of PTP too. BA abolished the action about of 1 mM ADP, but was not able to induce swelling of mitochondria in the presence of 2 mM ADP. We conclude that the outer side of inner mitochondrial membrane has a low affinity sensor for ADP, modifying the activity of PTP. The pathophysiological importance of this process could be an endogenous prevention of PT at conditions of energetic depression.  (+info)

Dinitrophenol-induced mitochondrial uncoupling in vivo triggers respiratory adaptation in HepG2 cells. (3/10)

Here, we show that 3 days of mitochondrial uncoupling, induced by low concentrations of dinitrophenol (10 and 50 microM) in cultured human HepG2 cells, triggers cellular metabolic adaptation towards oxidative metabolism. Chronic respiratory uncoupling of HepG2 cells induced an increase in cellular oxygen consumption, oxidative capacity and cytochrome c oxidase activity. This was associated with an upregulation of COXIV and ANT3 gene expression, two nuclear genes that encode mitochondrial proteins involved in oxidative phosphorylation. Glucose consumption, lactate and pyruvate production and growth rate were unaffected, indicating that metabolic adaptation of HepG2 cells undergoing chronic respiratory uncoupling allows continuous and efficient mitochondrial ATP production without the need to increase glycolytic activity. In contrast, 3 days of dinitrophenol treatment did not change the oxidative capacity of human 143B.TK(-) cells, but it increased glucose consumption, lactate and pyruvate production. Despite a large increase in glycolytic metabolism, the growth rate of 143B.TK(-) cells was significantly reduced by dinitrophenol-induced mitochondrial uncoupling. We propose that chronic respiratory uncoupling may constitute an internal bioenergetic signal, which would initiate a coordinated increase in nuclear respiratory gene expression, which ultimately drives mitochondrial metabolic adaptation within cells.  (+info)

Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats. (4/10)

We proposed that inhibition of mitochondrial adenine nucleotide translocator (ANT) by long chain acyl-CoA (LCAC) underlies the mechanism associating obesity and type 2 diabetes. Here we test that after long-term exposure to a high-fat diet (HFD): (i) there is no adaptation of the mitochondrial compartment that would hinder such ANT inhibition, and (ii) ANT has significant control of the relevant aspects of oxidative phosphorylation. After 7 weeks, HFD induced a 24+/-6% increase in hepatic LCAC concentration and accumulation of the oxidative stress marker N(epsilon)-(carboxymethyl)lysine. HFD did not significantly affect mitochondrial copy number, oxygen uptake, membrane potential (Deltapsi), ADP/O ratio, and the content of coenzyme Q(9), cytochromes b and a+a(3). Modular kinetic analysis showed that the kinetics of substrate oxidation, phosphorylation, proton leak, ATP-production and ATP-consumption were not influenced significantly. After HFD-feeding ANT exerted considerable control over oxygen uptake (control coefficient C=0.14) and phosphorylation fluxes (C=0.15), extra- (C=0.23) and intramitochondrial (C=-0.56) ATP/ADP ratios, and Deltapsi (C=-0.11). We conclude that although HFD induces accumulation of LCAC and N(epsilon)-(carboxymethyl)lysine, oxidative phosphorylation does not adapt to these metabolic challenges. Furthermore, ANT retains control of fluxes and intermediates, making inhibition of this enzyme a more probable link between obesity and type 2 diabetes.  (+info)

Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. (5/10)

Mitochondrial adenine nucleotide translocase (ANT) is believed to be a component or a regulatory component of the mitochondrial permeability transition pore (mtPTP), which controls mitochondrial permeability transition during apoptosis. However, the role of ANT in apoptosis is still uncertain, because hepatocytes isolated from ANT knockout and wild-type mice are equally sensitive to TNF- and Fas-induced apoptosis. In a screen for genes required for tumor necrosis factor alpha (TNF-alpha)-induced apoptosis in MCF-7 human breast cancer cells using retrovirus insertion-mediated random mutagenesis, we discovered that the ANT3 gene is involved in TNF-alpha-induced cell death in MCF-7 cells. We further found that ANT3 is selectively required for TNF- and oxidative stress-induced cell death in MCF-7 cells, but it is dispensable for cell death induced by several other inducers. This data supplements previous data obtained from ANT knockout studies, indicating that ANT is involved in some apoptotic processes. We found that the resistance to TNF-alpha-induced apoptosis observed in ANT3 mutant (ANT3(mut)) cells is associated with a deficiency in the regulation of the mitochondrial membrane potential and cytochrome c release. It is not related to intracellular ATP levels or survival pathways, supporting a previous model in which ANT regulates mtPTP. Our study provides genetic evidence supporting a role of ANT in apoptosis and suggests that the involvement of ANT in cell death is cell type- and stimulus-dependent.  (+info)

Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells. (6/10)

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Overexpression of GAP-43 reveals unexpected properties of hippocampal mossy fibers. (7/10)

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Full-length enriched cDNA library construction from tissues related to energy metabolism in pigs. (8/10)

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OBJECTIVES:. Assess the efficacy of raising and maintaining hemoglobin (Hgb) levels above 12.0 g/dL with epoetin alfa vs maintaining Hgb levels above 10.0 g/dL without epoetin alfa on progression-free survival, overall survival, and local control in anemic patients with cervical cancer receiving concurrent radiotherapy and cisplatin. Compare the quality of life of patients treated with these regimens.. OUTLINE:. This is a randomized study. Patients are stratified according to stage (IIB vs IIIB vs IVA), method of brachytherapy (low-dose vs high-dose), and surgical staging of para-aortic nodes (yes vs no). Patients are randomized to 1 of 2 treatment arms.. Arm I: Patients undergo radiotherapy comprising pelvic external beam radiotherapy daily five days a week for 5 weeks, followed by either 1 or 2 implants of low-dose rate intracavitary brachytherapy or 5 fractions of high-dose rate intracavitary brachytherapy, followed by 3-5 days of parametrial boost radiotherapy. Patients receive cisplatin IV ...
Sigma-Aldrich offers abstracts and full-text articles by [I R Kniazeva, V V Ivanov, M A Bolshakov, L P Zharkova, A V Kereia, O P Kutenkov, V V Rostov].
A study on Anole lizards deliberately introduced to various islands found much the same thing. It seems that phenotypic plasticity can take up the slack in the short term, resulting in physical changes without the need for any genetic change. The same may be the case in this instance ...
anole lizard stock photography , travel photography and stock images of travel destinations worldwide by award winning travel photographer David Sanger
Any medical information provided by this site is not a replacement for medical diagnosis, treatment, or professional medical advice. It should not be used to treat or diagnose any medical condition. Always seek professional medical consultation by a licensed physician for diagnosis and treatment of any and all medical conditions - please, do not ignore your doctors medical advice based on information written by the author or commenters of this site. Please do not ask me for medical advice, but instead contact a healthcare provider in your area. Anything written about office/hospital situations/events are fictional examples to get a point across. No patient is/will ever be a specific patient (unless given written permission), but a fictional one. To know more about how I handle medical information about patients please link here. Unless, I am praising a colleague, even those will be fictional. Any similarities to you or people you know is purely coincidental. My husband and I, and our dogs are ...
Anoles are part of the Dactyloidae family. They are native to the warmer parts of North America. Anoles are either a green or a brownish color average size is around 15cm in total length. They have some of the characteristics as geckos as having the same foot structure for climbing and can break off part of its tail to
Unique research by UC Riverside biologists on wild anole lizards reveals new insights on how animals might adapt to their habitat and handle various forms of motion.
The first non-avian reptile genome has been sequenced, that of the North American green anole lizard (Anolis carolinensis). The anole is an emerging model for the study of adaptive radiation and convergent evolution. The genome includes a previously unknown X chromosome, with no homology to known amniote sex chromosomes, and microchromosomes that share a common ancestry with those in birds, but without their unusual characteristics. The evolution of the amniotic egg was one of the great evolutionary innovations in the history of life, freeing vertebrates from an obligatory connection to water and thus permitting the conquest of terrestrial environments1. Among amniotes, genome sequences are available for mammals and birds2,3,4, but not for non-avian reptiles. Here we report the genome sequence of the North American green anole lizard, Anolis carolinensis. We find that A. carolinensis microchromosomes are highly syntenic with chicken microchromosomes, yet do not exhibit the high GC and low repeat content
Green Anole Stock Photo. csp7390979 - Male green anole lizard found in puerto rico forest. Affordable Royalty Free Stock Photography. Downloads for just $2.50, with thousands of images added daily. Subscriptions available for just $39.00. Our stock photo image search engine contains royalty free photos, vector clip art images, clipart illustrations.
Evading a hungry predator is essential if your genes are to contribute to the game of life and speed is usually of the essence. However, its not always that simple. Animals often drop their speed in favour of agility as they try to outmanoeuvre pursuers. And what happens if you take the pursuit into the trees, where prey have to negotiate branches of different girth? Wondering how green anole lizards adapt their flight in different contexts, Erik Sathe and Jerry Husak from the University of St Thomas, USA, began investigating how animals of different builds sprinted along branches of different widths, along the flat and through a maze of peg obstacles to find out which physical attributes prepared the lizards best for escape.. Sure enough, the sprinting animals were fastest on a flat surface and the broadest pole (5 cm), reaching speeds of over 1.4 m s−1, but they dropped to 0.8 m s−1 on the 2.5 cm pole and were reduced to a crawl (0.4 m s−1) through the maze of pegs. Next, they ...
This film explores the adaptation of anole lizards (genus Anolis) to habitats common across the islands of the Caribbean. The anoles are excellent examples of adaptive radiation, convergent evolution, and speciation through reproductive isolation.. ...
In seven interactive virtual labs, identify bacteria, examine heart patients, probe the nervous system, assay antibodies, study circadian rhythms, and analyze evolution in action in stickleback fish. Lizard Evolution Virtual Lab: Explore the evolution of the anole lizards in the Caribbean.... ...
In seven interactive virtual labs, identify bacteria, examine heart patients, probe the nervous system, assay antibodies, study circadian rhythms, and analyze evolution in action in stickleback fish. Lizard Evolution Virtual Lab: Explore the evolution of the anole lizards in the Caribbean.... ...
Information on species ranges and phylogenetic relationships are key in historic biogeographical inference. In South America, our understanding of the evolutionary processes that underlie biodiversity patterns varies enormously throughout areas. Little is thought, as an illustration, in regards to the drivers of excessive endemism within the southern montane area of the Atlantic Rainforest. On this area, former biogeographic connections with different South American ecosystems have been invoked to clarify the phylogenetic affinities of quite a few endemic taxa.. his will likely even be the case of the montane anole lizards Anolis nasofrontalis and A. pseudotigrinus, recognized from few specimens collected greater than 40years in the past. We mix new genetic information with printed sequences of species within the Dactyloa clade of Anolis to analyze the phylogenetic relationships of A. nasofrontalis and A. pseudotigrinus, in addition to estimate divergence instances from their closest ...
Information on species ranges and phylogenetic relationships are key in historic biogeographical inference. In South America, our understanding of the evolutionary processes that underlie biodiversity patterns varies enormously throughout areas. Little is thought, as an illustration, in regards to the drivers of excessive endemism within the southern montane area of the Atlantic Rainforest. On this area, former biogeographic connections with different South American ecosystems have been invoked to clarify the phylogenetic affinities of quite a few endemic taxa.. his will likely even be the case of the montane anole lizards Anolis nasofrontalis and A. pseudotigrinus, recognized from few specimens collected greater than 40years in the past. We mix new genetic information with printed sequences of species within the Dactyloa clade of Anolis to analyze the phylogenetic relationships of A. nasofrontalis and A. pseudotigrinus, in addition to estimate divergence instances from their closest ...
Recently developed technologies have enabled multi-well measurement of O2 consumption, facilitating the rate of mitochondrial research, particularly regarding the mechanism of action of drugs and proteins that modulate metabolism. Among these technologies, the Seahorse XF24 Analyzer was designed for use with intact cells attached in a monolayer to a multi-well tissue culture plate. In order to have a high throughput assay system in which both energy demand and substrate availability can be tightly controlled, we have developed a protocol to expand the application of the XF24 Analyzer to include isolated mitochondria. Acquisition of optimal rates requires assay conditions that are unexpectedly distinct from those of conventional polarography. The optimized conditions, derived from experiments with isolated mouse liver mitochondria, allow multi-well assessment of rates of respiration and proton production by mitochondria attached to the bottom of the XF assay plate, and require extremely small quantities
We sometimes assume that reptiles cannot be as smart as mammals because they are exothermic (cold-blooded) rather than endothermic (warm-blooded), and the brain is a high metabolic area. Here, though, we find some surprises.. Reptiles lack some brain structures found in mammals but they can use what theyve got for behavior that we would describe as intelligent: Crocodilians (alligators and crocodiles) have been reported to use sticks as decoys, play, and work in teams.. Exothermy slows intelligence but does not absolutely prevent it: Anole lizards were found as capable as tits (birds) in a problem-solving test for a food reward. But the anoles, being exothermic, dont need much food - which, of course, hinders research.. Even fish have shown signs of what seems like intelligence ...
Do you ever notice yourself resisting events happening in your life? We all go through many different experiences, this article is not to say we cannot make changes and choose to avoid very un-favorable experiences, it is simply to say, sometimes we can find ourselves being very resistant to changes that are going on in […]
A computational model for the ATP-ADP steady-state exchange rate mediated by adenine nucleotide translocase (ANT) versus mitochondrial membrane potential dependence in isolated rat liver mitochondria is presented. The model represents the system of three ordinary differential equations, and the basic components included are ANT,...
The Barbados anole (Anolis extremus) is a species of anole lizard that is native to Barbados, an island-nation in the Caribbean. Originally endemic to Barbados, it has since been introduced to Saint Lucia and Bermuda. It was previously treated as a subspecies of Martiniques anole (A. roquet). Males have pale lavender to blue-gray heads, with blue eyelids. Their dorsal surfaces are deep green with dark markings and occasionally white spots, and their bellies are yellow. Females are smaller and duller in color and may have a mid-dorsal stripe. It remains widespread and abundant on Barbados, where it is the only anole species. It adapts well to populated environments. It has been reported in Florida since the 1990s, though this is likely due to repeated introductions and escapes as a sustained, breeding population has not been confirmed. List of Anolis lizards Malhotra & Thorpe 1999, pp. 97, 119. Description of both sexes at Malhotra & Thorpe 1999, p. 97. Malhotra & Thorpe 1999, p. 97; Government ...
Copyright 2012 by Jenny A. Gubler. This material is copyrighted and any further reproduction or distribution is prohibited without the permission of the copyright owner ...
Copyright 2012 by Jenny A. Gubler. This material is copyrighted and any further reproduction or distribution is prohibited without the permission of the copyright owner ...
Rabbit polyclonal Adenine Nucleotide Translocator 2 antibody validated for WB, IP and tested in Human. With 2 independent reviews. Immunogen corresponding to…
Synonyms for Adenine nucleotide translocator in Free Thesaurus. Antonyms for Adenine nucleotide translocator. 1 synonym for adenine: A. What are synonyms for Adenine nucleotide translocator?
TY - JOUR. T1 - Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase. AU - Nadtochiy, Sergiy M.. AU - Zhu, Qiuyu. AU - Urciuoli, William. AU - Rafikov, Ruslan. AU - Black, Stephen M.. AU - Brookes, Paul S.. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2012/1/27. Y1 - 2012/1/27. N2 - Electrophilic nitrated lipids (nitroalkenes) are emerging as an important class of protective cardiovascular signaling molecules. Although species such as nitro-linoleate (LNO 2) and nitro-oleate can confer acute protection against cardiac ischemic injury, their mechanism of action is unclear. Mild uncoupling of mitochondria is known to be cardioprotective, and adenine nucleotide translocase 1 (ANT1) is a key mediator of mitochondrial uncoupling. ANT1 also contains redox-sensitive cysteines that may be targets for modification by nitroalkenes. Therefore, in this study we tested the hypothesis that nitroalkenes directly modify ANT1 and that nitroalkene-mediated ...
Adenine Nucleotide Translocator 1: A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).
Anole Bourbon Nut Brown brewed by Dead Lizard Brewing Company as an Brown Ale - American style beer, which has 3.5 out of 5, with 442 ratings and reviews on Untappd.
Looking for online definition of adenine nucleotide translocator 1 in the Medical Dictionary? adenine nucleotide translocator 1 explanation free. What is adenine nucleotide translocator 1? Meaning of adenine nucleotide translocator 1 medical term. What does adenine nucleotide translocator 1 mean?
George Gorman, who pioneered the use of molecular tools to study anole phylogenetics from the late 1960s to the early 1980s, asks:. Why not examine karyotypes of Dactyloa?. He says:. In the 1960s and 70s, before the DNA revolution, the systematic examination of karyotypes of reptilian taxa mushroomed, and, to some extent helped orient our thinking about relationships among various clades. This was certainly the case within Anolis at various hierarchical levels, from species determination to definition of distinct species groups. To my knowledge, there has been very little added to our knowledge about karyotypes of mainland Anolis that Etheridge placed in the latifrons series of Alpha Anolis, now frequently referred to as the Dactyloa clade. (if these are long-lost terms, Etheridges Beta anoles are the Norops section; all other lineages are within his Alpha section).. Background. There is a very pervasive, either primitive or convergently arrived at, karyotype among the ...
Ok, so I found a free anole in my terrarium which probably hatched out of one of my plants that Id ordered. That doesnt men havent spent a lot on h
Graham BH et al. (1997) A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator.. [^] ...
Got ant problems and wondering what kills ants? Heres how to get rid of ants with items you already own-and learn how to kill ants for good.
Slc25a4 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 (cDNA clone, (10ug), 10 µg.
Bongkrekic acid (BKA) is a strong inhibitor of adenine nucleotide translocase (ANT), inducing inhibition of adenosine triphosphate synthesis. We designed and synthesized simplified benzene-ring-containing BKA analogs. The key reaction is the one-pot double Sonogashira reaction, which forms the main skeleton. The analogs were efficiently synthesized in 8-10 longest linear sequence steps. This synth ...
I know I read someones comments about ants in their RV but I cant find the thread. CRS perhaps. Anyway. Prior to loading up the other day the wife says there are ants in the bedroom of the MH. What
Kim JY, So KJ, Lee S, Park JH (Sep 2012). "Bcl-rambo induces apoptosis via interaction with the adenine nucleotide translocator ... Bcl-rambo mediates apoptosis by associating with adenine nucleotide translocator (ANT), a component of the mitochondrial ... 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. Banga S, Gao P, Shen X, Fiscus V, Zong WX, Chen ... 534 (1-3): 61-8. doi:10.1016/S0014-5793(02)03778-X. PMID 12527362. S2CID 7018829. Human BCL2L13 genome location and BCL2L13 ...
"Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science. 281 (5385): 2027-31. ... Weng C, Li Y, Xu D, Shi Y, Tang H (March 2005). "Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related ... 2 (3): 238-40. doi:10.4161/auto.2730. PMID 16874066. McArthur, Kate; Whitehead, Lachlan W.; Heddleston, John M.; Li, Lucy; ... Nomura M, Shimizu S, Sugiyama T, Narita M, Ito T, Matsuda H, Tsujimoto Y (2003). "14-3-3 Interacts directly with and negatively ...
... myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator". ... MT-TG is a small 68 nucleotide transfer RNA (human mitochondrial map position 9991-10058) that transfers the amino acid glycine ... "Maternally inherited hypertrophic cardiomyopathy due to a novel T-to-C transition at nucleotide 9997 in the mitochondrial tRNA( ... 55 (3): 437-46. PMC 1918404. PMID 8079988. Bidooki SK, Johnson MA, Chrzanowska-Lightowlers Z, Bindoff LA, Lightowlers RN (June ...
... myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator". ... MT-TT is a small 66 nucleotide RNA (human mitochondrial map position 15888-15953) that transfers the amino acid threonine to a ... 16 (3): 226-34. doi:10.1038/ng0797-226. PMID 9207786. Grasbon-Frodl EM, Kösel S, Sprinzl M, von Eitzen U, Mehraein P, Graeber ... 176 (3): 1112-5. doi:10.1016/0006-291X(91)90399-R. PMID 1645537. Reference, Genetics Home. "MT-TT gene". Genetics Home ...
... but also to prevent mitochondria from straining glycolytic ATP reserves by maintaining the adenine nucleotide translocator in ' ... "Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level ... "Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues". The Journal of ... ISBN 978-3-642-33430-6. Agteresch, Hendrik J.; Dagnelie, Pieter C.; van den Berg, J Willem; Wilson, J H. (1999). "Adenosine ...
... adenine nucleotide translocator 1 MeSH D12.776.575.750.500.200 - adenine nucleotide translocator 2 MeSH D12.776.575.750.500.300 ... adenine nucleotide translocator 3 MeSH D12.776.580.210.175.325 - groes protein MeSH D12.776.580.210.180.325 - groel protein ... actin-related protein 3 MeSH D12.776.220.525.475.100 - myosin heavy chains MeSH D12.776.220.525.475.200 - myosin light chains ... type 3 MeSH D12.776.624.664.700.130 - muts homolog 2 protein MeSH D12.776.624.664.700.148 - myeloid-lymphoid leukemia protein ...
... adenine nucleotide translocator 1 MeSH D12.776.157.530.625.875.500.200 - adenine nucleotide translocator 2 MeSH D12.776.157.530 ... 500.300 - adenine nucleotide translocator 3 MeSH D12.776.157.530.750.100 - aryl hydrocarbon receptor nuclear translocator MeSH ... nucleotide transport proteins MeSH D12.776.157.530.625.875.500 - mitochondrial adp, atp translocases MeSH D12.776.157.530. ... aquaporin 3 MeSH D12.776.157.530.400.500.040.249.750 - aquaporin 6 MeSH D12.776.157.530.400.500.040.374 - aquaporin 1 MeSH ...
Adenine nucleotide translocator (ANT) 2.B: Nonribosomally synthesized porters, such as: The Nigericin family The Ionomycin ... such as rhodopsin The group translocators provide a special mechanism for the phosphorylation of sugars as they are transported ... 38 (3): 305-315. doi:10.1016/j.tips.2016.11.008. ISSN 1873-3735. PMID 27939446. Sadava, David, et al. Life, the Science of ... chloroplast ATP synthase1 3.B: Decarboxylation-driven transporters 3.C: Methyltransfer-driven transporters 3.D: Oxidoreduction- ...
... adenine nucleotide translocator-3 on the Y), AZF2 (azoospermia factor 2), BPY2 (basic protein on the Y chromosome), AZF1 ( ... interleukin-3 receptor), SRY (sex-determining region), TDF (testis determining factor), ZFY (zinc finger protein), PRKY ( ...
... adenine nucleotide translocator 1 MeSH D12.776.543.585.450.162.235.200 - adenine nucleotide translocator 2 MeSH D12.776.543.585 ... adenine nucleotide translocator 1 MeSH D12.776.543.585.625.875.500.200 - adenine nucleotide translocator 2 MeSH D12.776.543.585 ... 500.300 - adenine nucleotide translocator 3 MeSH D12.776.543.585.750.100 - aryl hydrocarbon receptor nuclear translocator MeSH ... 235.300 - adenine nucleotide translocator 3 MeSH D12.776.543.585.450.162.276 - potassium-hydrogen antiporters MeSH D12.776. ...
"Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR ... Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T (April 1988). "Nucleotide sequence of a cDNA ... doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Valnot I, Kassis J, Chretien D, de Lonlay P, Parfait B, Munnich A, Kachaner J ... Yuan J, Murrell GA, Trickett A, Wang MX (June 2003). "Involvement of cytochrome c release and caspase-3 activation in the ...
Adenine+Nucleotide+Translocator+1 at the US National Library of Medicine Medical Subject Headings (MeSH) Adenine+Nucleotide+ ... Translocator+2 at the US National Library of Medicine Medical Subject Headings (MeSH) Adenine+Nucleotide+Translocator+3 at the ... Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or ... Pressman BC (June 1958). "Intramitochondrial nucleotides. I. Some factors affecting net interconversions of adenine nucleotides ...
UCP1 is very similar to the ATP/ADP Carrier protein, or Adenine Nucleotide Translocator (ANT). The proposed alternating access ... UCP1 is related to other mitochondrial metabolite transporters such as the adenine nucleotide translocator, a proton channel in ... UCP1 is activated in the brown fat cell by fatty acids and inhibited by nucleotides. Fatty acids are released by the following ... overriding the inhibition caused by purine nucleotides (GDP and ADP). During the termination of thermogenesis, thermogenin is ...
... thiols in the mitochondrial permeability transition pore component adenine nucleotide translocator (ANT). Overexpression of ... "Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer". Cancer Research. ... 443 (3): 821-7. doi:10.1016/j.bbrc.2013.12.050. PMID 24342608. Wang Z, Zhang H, Li XF, Le XC (2007). "Study of interactions ... Two mRNA transcripts of the TXN2 gene differ by ~330 bp in the length of the 3′-untranslated region, and both are believed to ...
Actor-network theory, an approach to social theory and research Adenine nucleotide translocator Anacamptis (abbreviation Ant), ... ISO 3166-1 alpha-3 country code) River Ant, a river in Norfolk, England Ant (name), English language nickname abbreviated from ...
... but also to prevent mitochondria from straining glycolytic ATP reserves by maintaining the adenine nucleotide translocator in ' ... "Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level ... 54 (3): 143-4. doi:10.1080/15216540214539. PMID 12489642.. *^ Wilson DF, Erecińska M, Schramm VL (1983). "Evaluation of the ... 978-3-642-33430-6. .. *^ Agteresch, Hendrik J.; Dagnelie, Pieter C.; van den Berg, J Willem; Wilson, J H. (1999). "Adenosine ...
ROS increases uncoupling proteins (UCPs) and potentiate proton leakage through the adenine nucleotide translocator (ANT), the ... Nachman MW, Crowell SL (September 2000). "Estimate of the mutation rate per nucleotide in humans". Genetics. 156 (1): 297-304. ... Tumor cells require ample ATP to synthesize bioactive compounds such as lipids, proteins, and nucleotides for rapid ... The VDAC is the primary transporter of nucleotides, ions and metabolites between the cytosol and the intermembrane space. It is ...
... the inner membrane protein adenine nucleotide translocator (AdNT) and the matrix protein cyclophilin D (CyD) (12). This pore ... It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. ... A short linker and nucleotide binding a/b domains (NBD) that contain conserved Walker boxes A (p-loop 155-161) and B (239-243) ... Another model proposes that Apaf-1 is organized in an extended fashion such that both the N-terminal CARD and the nucleotide ...
Adenine nucleotide translocator. *Adenosine deaminase. *Adenosylmethionine decarboxylase. *Adenylosuccinate synthase. *AdoMet ...
SLC25A25 adenine nucleotide - SLC25A4, SLC25A5, SLC25A6, SLC25A31 dicarboxylate - SLC25A10 oxoglutarate - SLC25A11 glutamate - ... "Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential". Journal ... Mitochondrial carriers transport amino acids, keto acids, nucleotides, inorganic ions and co-factors through the mitochondrial ... nucleotides, amino acids, keto acids and cofactors across the membrane. Such proteins include: ADP/ATP carrier protein (ADP-ATP ...
Further hypothesis by Halestrap's group convincingly suggested the MPT was formed by the inner membrane Adenine Nucleotide ... "The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore". Nature. 427 (6973): 461-465. doi ... "The nature of the calcium ion efflux induced in rat liver mitochondria by the oxidation of endogenous nicotinamide nucleotides ... "Regulation of the Inner Membrane Mitochondrial Permeability Transition by the Outer Membrane Translocator Protein (Peripheral ...
Adenine+Nucleotide+Translocator+1 at the US National Library of Medicine Medical Subject Headings (MeSH) Adenine+Nucleotide+ ... Translocator+2 at the US National Library of Medicine Medical Subject Headings (MeSH) Adenine+Nucleotide+Translocator+3 at the ... Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or ... Pressman BC (June 1958). "Intramitochondrial nucleotides. I. Some factors affecting net interconversions of adenine nucleotides ...
Rabbit polyclonal Adenine Nucleotide Translocator 2/ANT 2 antibody. Validated in WB, IHC and tested in Human. Independently ... Anti-Adenine Nucleotide Translocator 2/ANT 2 antibody. See all Adenine Nucleotide Translocator 2/ANT 2 primary antibodies. ... All lanes : Anti-Adenine Nucleotide Translocator 2/ANT 2 antibody (ab221956) at 1/100 dilution. Lane 1 : RT-4 cell lysate. Lane ... This product Rabbit Anti-Adenine Nucleotide Translocator 2/ANT 2 antibody (ab221956) IHC-P, WB ...
Rabbit polyclonal Adenine Nucleotide Translocator 2 antibody validated for WB, IP and tested in Human. With 2 independent ... Anti-Adenine Nucleotide Translocator 2 antibody. See all Adenine Nucleotide Translocator 2 primary antibodies. ... Immunoprecipitation of Adenine Nucleotide Translocator 2 transfected lysate using ab118125 and Protein A Magnetic Bead, and ... Recombinant full length protein, corresponding to amino acids 1-298 of Human Adenine Nucleotide Translocator 2 (NP_001143.2). ...
Adenine Nucleotide Translocator 1: A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM ... Adenine Nucleotide Translocator 1. Subscribe to New Research on Adenine Nucleotide Translocator 1 ... ANT-1 Transport Protein; ANT1 Transport Protein; Adenine Nucleotide Carrier Protein; Adenine Nucleotide Translocator, Muscle ... Nucleotide Transport Proteins*ATP Translocases Mitochondrial ADP: 95*Adenine Nucleotide Translocator 1: 14 ...
Adenine nucleotide translocator 1 (IPR002113). Homologous superfamilies. * Homologous superfamily. 1 50 100 150 200 250 298 ...
Adenine nucleotide translocator 3. Short name: ANT 3. Solute carrier family 25 member 6 ... "Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects ... "Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects ... adeninenucleotide translocator), member 6 (SLC25A6), mRNA, RefSeq: NM_001636.1. MACFA ...
Adenine nucleotide translocator 3. Short name: ANT 3. ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_ ... purine nucleotide transport Source: TAIRInferred from direct assayi*. "Functional integration of mitochondrial and ... Nucleotide carrier signature motifBy similarity. Manual assertion inferred from sequence similarity toi ... ADP,ATP carrier protein 3, mitochondrialAdd BLAST. 310. Proteomic databases. PaxDb, a database of protein abundance averages ...
Deficiency of the adenine nucleotide translocator in muscle of a patient with myopathy and lactic acidosis: a new mitochondrial ... The adenine nucleotide translocator (ANT) transports ATP out of the mitochondrion. Deficiencies have been found in all OXPHOS ... adenine nucleotide translocator; mtDNA, mitochondrial DNA; CCCP, carbonyl cyanide 3-chlorophenyl hydrazone; CS, citrate ... 3.) De Meirleir L. Defects of pyruvate metabolism and the Krebs cycle. J Child Neurol 2002;17:26-33. (4.) Triepels RH, Hanson ...
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science (1998) 281:2027-31. doi: ... ANT, adenine nucleotide translocator; Bax, Bcl-2-associated protein X; Bak, Bcl-2 homologous antagonist killer; Bcl-2, B-cell ... Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator. Oncogene (2000) 19:329-36. ... the adenine nucleotide translocator ANT-2 is upregulated in renal tumors and transformed hepatocytes (78). This upregulation, ...
Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6, Pseudogene 1 2 3 ... Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6 Pseudogene 3 ... Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 5-Like 2 ... The GeneCards human gene database index: 1 2 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
Protein Aliases: AAC3; adenine nucleotide translocator 2; Adenine nucleotide translocator 3; adenine nucleotide translocator 3 ... adenine nucleotide translocator), member 6; Solute carrier family 25 member 6; solute carrier family 25, member A6 ... translation protein targeting to mitochondrion apoptotic process adenine transport ADP transport ATP transport active induction ... structural constituent of ribosome ATP:ADP antiporter activity protein binding adenine transmembrane transporter activity ...
... adenine nucleotide translocator 2 , adenine nucleotide translocator 3 (liver) , solute carrier family 25, member A6 , solute ... Adenine Nucleotide Translocator), Member 6 (SLC25A6) * Solute Carrier Family 25 (Mitochondrial Carrier, Adenine Nucleotide ... Adenine Nucleotide Translocator), Member 5 ELISA Kits * Solute Carrier Family 25 (Mitochondrial Carrier, Adenine Nucleotide ... ADP/ATP translocator of liver , adenine nucleotide translocator 3 , solute carrier family 25 member 6 , ANT 2 , ANT 3 , ...
Abbreviations: ANT, adenine nucleotide translocator; BMI, body mass index; MPTP, mitochondrial permeability transition pore; ...
The objective of this study was to identify single-nucleotide polymorphisms using a bovine chromosome 14 high-density SNP panel ... 8100217 - Genetic mapping of human heart-skeletal muscle adenine nucleotide translocator and its .... 19025667 - Chromosomal ... The objective of this study was to identify single-nucleotide polymorphisms using a bovine chromosome 14 high-density SNP panel ... One SNP in particular, ss61514555:A,C, showed association with 3 of the 5 traits: milk (p = 1.59E-04), fat (p = 6.88E-05) and ...
Kim JY, So KJ, Lee S, Park JH (Sep 2012). "Bcl-rambo induces apoptosis via interaction with the adenine nucleotide translocator ... Bcl-rambo mediates apoptosis by associating with adenine nucleotide translocator (ANT), a component of the mitochondrial ... 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. Banga S, Gao P, Shen X, Fiscus V, Zong WX, Chen ... 534 (1-3): 61-8. doi:10.1016/S0014-5793(02)03778-X. PMID 12527362. S2CID 7018829. Human BCL2L13 genome location and BCL2L13 ...
The SLC25A4 gene provides the instructions for making a protein called adenine nucleotide translocase type 1 (ANT1). Learn ... Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup. Proc ... Complete loss-of-function of the heart/muscle-specific adenine nucleotide translocator is associated with mitochondrial ... The adenine nucleotide translocase type 1 (ANT1): a new factor in mitochondrial disease. IUBMB Life. 2005 Sep;57(9):607-14. ...
"Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes in Arabidopsis thaliana are ... The adenine nucleotide translocator of higher plants is synthesized as a large precursor that is processed upon import into ... Two genes encode the adenine nucleotide translocator of maize mitochondria. Isolation, characterisation and expression of the ... Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes... Carrie, Chris; Murcha, ...
Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction. ... myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. ... The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. ... Diet-induced obesity in two C57BL/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) gene. ...
Increased levels of adenine nucleotide translocator 1 protein and response to oxidative stress are early events in ... DUX4 transcript from the last D4Z4 (most telomeric) unit generates small si/miRNA-sized fragments; uncapped, polyadenylated 3- ...
The human adenine nucleotide translocator sub-family is composed of four isoforms, namely ANT1-4, encoded by four nuclear genes ... The adenine nucleotide translocator (ANT) is a mitochondrial bi-functional protein, which catalyzes the exchange of ADP and ATP ... The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells. ... The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells. International ...
... adenine nucleotide translocator 1 (ANT1); adPEO, Sengers syndrome (SLC25A4). Valine 181 is critical for the nucleotide exchange ... Adenine nucleotide transporter, ANT, or ATP:ADP carrier AAC1 (one of three paralogues). Transports heme and heme precursor ... Adenine nucleotide (ATP, ADP) carrier, ANT1; BRITTLE-1. Present in both mitochondria and plastids (Haferkamp and Schmitz-Esser ... The Endoplasmic Reticular Adenine Nucleotide Transporter, ER-ANT1 (probable ATP:ADP exchanger; Leroch et al., 2008) ...
Mitochondrial ADP/ATP carrier 1 (AAC1); ADP/ATP translocase 1; adenine nucleotide translocator 1 (ANT1); adPEO, Sengers ... Adenine nucleotide transporter, ANT, or ATP:ADP carrier AAC1 (one of three paralogues). Transports heme and heme precursor ... Adenine nucleotide (ATP, ADP) carrier, ANT1; BRITTLE-1. Present in both mitochondria and plastids (Haferkamp and Schmitz-Esser ... The Endoplasmic Reticular Adenine Nucleotide Transporter, ER-ANT1 (probable ATP:ADP exchanger; Leroch et al., 2008) ...
... myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. Nat ... 3). Open image in new window. Fig. 3. Contents of the TarGo database. a The user can find the knock out (KO) target gene using ... 3a).. We performed gene selection using this system by predicting diabetes and obesity-related genes in mice. Six MP terms for ... 3.. Guan Y, Gorenshteyn D, Burmeister M, Wong AK, Schimenti JC, Handel MA, Bult CJ, Hibbs MA, Troyanskaya OG. Tissue-specific ...
Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT). Sihem ... Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) ... Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) ... Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) ...
Abbreviations: ANT, adenine nucleotide translocator; HRP, horseradish peroxidase; MCS, mitochondrial contact site; MIM, ... In mitochondria isolated from uMtCK transgenic mice, the number of contact sites increased 3-fold compared with that observed ...
... and ADP/ATP translocase 3 (SLC25A6) in the liver, and cytochrome c oxidase subunit 5B isoform 1 (COX5B1) in the liver and the ... Differential expression of adenine nucleotide translocator isoforms in mammalian tissues and during muscle cell differentiation ... Human cytomegalovirus miR-UL36-5p inhibits apoptosis via downregulation of adenine nucleotide translocator 3 in cultured cells ... Zamora M, Granell M, Mampel T, Viñas O. Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured ...
20 and adenine nucleotide translocator (ANT) 1/2/3/4 that regulate mitochondrial permeability. The results suggest that an ... The isolates were 20 and 26 nucleotide divergent from prototype Sabin strain (with 18 identical mutations) consistent with ... and Candida lusitaniae Targeting rDNA region nucleotide sequences, primers specific for C. auris only or C. auris and related ... RESULTS: In Ukraine, 3-dose polio vaccine coverage declined from 91% in 2008 to 15% by mid-2015. In summer, 2015, two unrelated ...
adenine nucleotide translocator. COX. Cytc oxidase. CPX. Cyt c peroxidase. DPH. 1,6-diphenyl-1,3,5-hexatriene. mtPOX. ... Fatty Acid Composition, Cytochrome c Oxidase, and Adenine Nucleotide Translocase Activities Aurelio De Santis, Pierangelo Landi ... Fatty Acid Composition, Cytochrome c Oxidase, and Adenine Nucleotide Translocase Activities Aurelio De Santis, Pierangelo Landi ... 1994) Effect of aging and acetyl-l-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat ...
ATP is transported to the cytosol by exchanging with ADP through adenine nucleotide translocator and used for various ... The specific roles of SIRT1, -3, and -4 in metabolism have been described in various tissues.186 SIRT1 activates PGC-1α, which ... Figure 3. Mitochondrial respiratory chain and nutrient metabolism. Reducing agents (NADH or FADH2) are generated from ... A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin ...
Other important cellular targets for disulfiram also exist, including Cys56 of the adenine nucleotide translocator that ... Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition ... 3. CRL1619 melanoma cells were plated at equal densities, grown to 80% confluence, and, in replicate experiments (n = 4 each), ... Figure 3. Complexation of Cu2+ reduces the antiproliferative activity of disulfiram. CRL1619 human melanoma cells stimulated ...
  • Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane. (wikipedia.org)
  • ATP and ADP are the only natural nucleotides recognized by the translocase. (wikipedia.org)
  • The SLC25A4 gene provides the instructions for making a protein called adenine nucleotide translocase type 1 (ANT1). (medlineplus.gov)
  • Thus, pore opening in the inner mitochondrial membrane results from the binding of Ca 2+ to the adenine nucleotide translocase. (tcdb.org)
  • Our findings indicate that the expression of coenzyme Q-binding protein (COQ10), cytochrome c oxidase subunit 6A2 (COX6A2) and ADP/ATP translocase 3 (SLC25A6) in the liver, and cytochrome c oxidase subunit 5B isoform 1 (COX5B1) in the liver and the skeletal muscle, are sensitive markers of the nutritional condition that may be relevant to assess the effect of changes in the feeding regime and diet composition on fish farming. (biomedcentral.com)
  • Adenine nucleotide translocase (ANT) is a nuclear-encoded protein abundantly located in the inner mitochondrial membrane, and the role of this protein is to catalyze the exchange of mitochondrial ATP with cytosolic ADP. (biomedcentral.com)
  • On 0, 1, 2, 3, 4, 6 weeks post injection, frequencies of splenic Tfh cells were determined by flow cytometric analysis, productions of IL-21 and anti-adenine nucleotide translocator(ANT) autoantibody were detected by enzyme-linked immunosorbent assay. (biomedcentral.com)
  • Anti-β1-adrenergic receptor autoantibodies, anti-adenine nucleotide translocator(ANT) autoantibodies and anti-cardiac myosin autoantibodies were common seen in VMC and DCM patients, suggesting the existence of abnormal humoral autoimmune responses in VMC. (biomedcentral.com)
  • and ophthalmoplegia with multiple mtDNA deletions, caused by adenine nucleotide translocator-1 (ANT1) mutations. (nih.gov)
  • Moreover, an overexpression of both sarco/endoplasmic Ca(2+)-ATPase (SERCA1) and adenine nucleotide translocator (ANT1), both factors related to cellular energetic efficiency, was observed. (lu.se)
  • Transport is fully reversible, and its directionality is governed by the concentrations of its substrates (ADP and ATP inside and outside mitochondria), the chelators of the adenine nucleotides, and the mitochondrial membrane potential. (wikipedia.org)
  • We developed a unique set of incubations with 3 carboxyl-[sup.14]C-labeled substrates, in combination with measurement of ATP production, in intact muscle mitochondria that gives maximum information about the MEGS capacity. (thefreelibrary.com)
  • In mitochondria isolated from uMtCK transgenic mice, the number of contact sites increased 3-fold compared with that observed in control mitochondria. (biochemj.org)
  • Cu/ZnSOD can use ONOO - to catalyze the nitration (NO 2 -Tyr) of mitochondrial protein tyrosine residues (bottom center) such as cyclophilin D (CyPD) and the adenine nucleotide translocator (ANT), which are core components of the mitochondrial permeability transition pore (PTP, another critical function of mitochondria). (nih.gov)
  • In the present investigation, we used the inhibitor CAtr (carboxyatractyloside) to examine the involvement of the ANT (adenine nucleotide translocator) in the mediation of this UCP1-independent fatty-acid-induced uncoupling in brown-fat mitochondria. (portlandpress.com)
  • Human mitochondria contain ∼1500-2000 proteins ( 3 ) and have an own genome (mtDNA) encoding 37 genes, including 13 proteins of the oxidative phosphorylation (OXPHOS), 22 tRNAs, and two rRNAs ( 4 ). (mcponline.org)
  • The main components of this pore are adenine nucleotide translocator and cyclophilin D in the inner membrane of the mitochondria, and voltage-dependent anion channel and peripheral benzodiazepine receptor in the outer mitochondrial membrane. (aacrjournals.org)
  • Shimizu, S., Shinohara, Y. and Tsujimoto, Y. Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator. (springer.com)
  • The researchers speculate that because the heart cells also produce ANT2, another form of the adenine nucleotide translocator protein, enough ATP gets out to prevent enlargement of the mitochondria. (thefreedictionary.com)
  • Phosphoproteome analysis of isoflurane-protected heart mitochondria: phosphorylation of adenine nucleotide translocator-1 on Tyr194 regulates mitochondrial function. (uzh.ch)
  • Vpr protein interacts with adenine nucleotide translocator (ANT, a component of mitochondrial permeability transition pore (PTP)) that is implicated in [Ca.sup.2+] influx into mitochondria. (thefreedictionary.com)
  • 38] proposed the participation of the Adenine Nucleotide Translocator (ANT) in the mitochondria as a new mechanism of protection against increased ROS production in aged skeletal muscle. (thefreedictionary.com)
  • To gain insight into the role of the general transcription factor, Sp1, in the expression of nuclear genes involved in mitochondrial biogenesis, we investigated Sp1 activation of the adenine nucleotide translocator 2, cytochrome c1, F1-ATPase beta subunit, and the mitochondria transcription factor (mtTFA) promoters transfected into Drosophila cell lines. (semanticscholar.org)
  • Mitochondria was initiated by addition of (3)H- ADP and terminated after 12 s by quick addition of ATR. (bvsalud.org)
  • Nonspecific binding of (3)H- ADP to mitochondria was estimated by incubation of mitochondrial samples with ATR prior to the addition of (3)H- ADP . (bvsalud.org)
  • Mitochondria were pre-incubated with CAT in a respiratory medium before ADP addition to initiate state 3 respiration . (bvsalud.org)
  • The density of ANT was determined by the amount of CAT required to completely inhibit state 3 respiration , assuming a 11 binding stoichiometry, which was expressed as ANT density per milligram mitochondria protein. (bvsalud.org)
  • Oliveira, PJ & Wallace, KB 2006, ' Depletion of adenine nucleotide translocator protein in heart mitochondria from doxorubicin-treated rats - Relevance for mitochondrial dysfunction ', Toxicology , vol. 220, no. 2-3, pp. 160-168. (elsevier.com)
  • Recombinant full length protein, corresponding to amino acids 1-298 of Human Adenine Nucleotide Translocator 2 (NP_001143.2). (abcam.com)
  • Immunoprecipitation of Adenine Nucleotide Translocator 2 transfected lysate using ab118125 and Protein A Magnetic Bead, and immunoblotted with an Adenine Nucleotide Translocator 2 mouse polyclonal antibody. (abcam.com)
  • C, showed association with 3 of the 5 traits: milk (p = 1.59E-04), fat (p = 6.88E-05) and protein yields (p = 5.76E-05). (biomedsearch.com)
  • An alternatively-spliced protein variant, called Bcl-rambo beta, is composed of only the BH4 domain, completely lacking the BH domains 1 through 3 due to an in-frame stop codon inserted by an Alu element. (wikipedia.org)
  • The transcription of the human UCP3 (uncoupling protein-3) gene in skeletal muscle is tightly regulated by metabolic signals related to fatty acid availability. (portlandpress.com)
  • Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAS. (wikipathways.org)
  • Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery. (wikipathways.org)
  • The HIV-1 encoded apoptogenic protein Vpr induces mitochondrial membrane permeabilization (MMP) via interactions with the voltage-dependent anion channel (VDAC) and the adenine nucleotide translocator (ANT). (nih.gov)
  • Because AHR associates with proteasomal complexes consisting of damaged-DNA-binding protein 1, aryl hydrocarbon receptor nuclear translocator , transducin-[beta]-like 3, and cullin 4B and itself possesses E3 ligase activity (Ohtake et al. (thefreedictionary.com)
  • The activity of ANT was expressed as nanomoles (3)H- ADP per minute per milligram protein. (bvsalud.org)
  • By using carboxyatractyloside as a specific modulator of ANT activity and Western blotting, we observed that following DOX treatment in rats: (1) the amount of "functional ANT" that contributes to cardiac mitochondrial respiration with different substrates is reduced, (2) titrations with carboxyatracyloside revealed a lower threshold for MPT induction and most importantly, (3) a specific decrease in the amount of the ANT protein. (elsevier.com)
  • Recombinant fragment corresponding to Human Adenine Nucleotide Translocator 2/ANT 2 aa 19-46. (abcam.com)
  • This PTP complex includes PBR, VDAC, adenine nucleotide translocator, and cyclophilin D ( 9 ). (aacrjournals.org)
  • Other studies have also suggested that MPTP potentially comprises a voltage-dependent anion channel (VDAC) and an adenine nucleotide transporter (ANT) [ 12 ]. (biomedcentral.com)
  • Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction. (nih.gov)
  • The mouse fetal and adult hearts express two adenine nucleotide translocator (ANT) isoform genes. (escholarship.org)
  • After receiving apoptotic signals, mitochondrial membrane permeability increases and the mediators such as cytochrome c and apoptosis-inducing factors are released to the cytoplasm, rapidly followed by the activations of caspase 9 and executive caspase 3 [ 2 ]. (biomedcentral.com)
  • Prononciation de nicotinamide adenine dinucleotide phosphate à 1 prononciation audio, 2 synonymes, 1 sens, 7 traductions, et de plus pour nicotinamide adenine dinucleotide phosphate. (losangelesorienteering.org)
  • Comment dire nicotinamide adenine dinucleotide phosphate Anglais? (losangelesorienteering.org)
  • Loss of NNT decreases the concentration of reduced nicotinamide adenine dinucleotide phosphate within the mitochondrial matrix. (escholarship.org)
  • Nicotinamide adenine dinucleotide phosphate is a cofactor for glutathione reductase, which regenerates reduced glutathione, an important antioxidant. (escholarship.org)
  • Using a knockin X-linked Ant2 allele in which exons 3 and 4 are flanked by loxP sites combined in males with a protamine 1 promoter driven Cre recombinase we created females heterozygous for a null Ant2 allele. (escholarship.org)
  • Adenine nucleotide translocator (ANT) 2 is highly expressed in proliferative cells, and ANT2 induction in cancer cells is known to be directly associated with glycolytic metabolisms and carcinogenesis. (biomedcentral.com)
  • Bcl-rambo mediates apoptosis by associating with adenine nucleotide translocator (ANT), a component of the mitochondrial permeability transition pore, to induce its opening. (wikipedia.org)
  • These data show that a low concentration of caffeine can induce p53-dependent apoptosis in JB6 cells through the Bax and caspase 3 pathways. (aacrjournals.org)
  • Adenine nucleotide transporter, ANT, or ATP:ADP carrier AAC1 (one of three paralogues). (tcdb.org)
  • Prononciation de flavin adenine dinucleotide à 1 prononciation audio, 1 sens, 11 traductions, et de plus pour flavin adenine dinucleotide. (losangelesorienteering.org)
  • cleotide Here are all the possible pronunciations of the word flavin-adenine dinucleotide. (losangelesorienteering.org)
  • Comment dire flavin adenine dinucleotide Anglais? (losangelesorienteering.org)
  • In biochemistry, flavin adenine dinucleotide is a redox cofactor, more specifically a prosthetic group, involved in several important reactions in metabolism. (losangelesorienteering.org)
  • 2,3 The metabolic actions of insulin maintain glucose homeostasis by promoting glucose uptake in skeletal muscle and suppressing glucose production in the liver. (ahajournals.org)
  • The thyroid gland primarily secretes T 4 (≈85%), which is converted to T 3 by 5′-monodeiodination in the liver, kidney, and skeletal muscle. (ahajournals.org)
  • There are currently no images for Kallikrein 3/PSA Antibody (NBP2-34768JF646). (novusbio.com)
  • Auto-antibody against adenine nucleotide translocator in dilated cardiomyopathy and myocarditis. (nii.ac.jp)
  • The human mitochondrion contains at least 100 different proteins directly involved in the mitochondrial energy-generating system (MEGS) [3] (1). (thefreelibrary.com)
  • Their genome is organized in eight RNA segments, encoding up to 13 proteins [ 1 , 2 , 3 ]. (mdpi.com)
  • Inactivation of uncoupler proteins (Ucp) 1-3 revealed that mitochondrial Delta Psi regulated ROS production. (nih.gov)
  • Poly(ADP-ribose) polymerases are a family of DNA-dependent nuclear enzymes catalyzing the transfer of ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide to a variety of target proteins. (cdc.gov)
  • Several yeast inner mitochondrial membrane proteins able to transport nucleotides have been identified. (biomedcentral.com)
  • Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes. (deepdyve.com)
  • The CGA approach may be limited because of probe selection in the Affymetrix Styl array.Among 498 SNPs associated with candidate genes, only 9 were located within exons {CYPJA2, ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2), EPHX1 [epoxide hydrolase 1, microsomal (xenobiotic)], EPHX2, CYP26B1, GSTM3 (glutathione S-transferase mu 3 (brain)], and CYP4B11 and 87 were located within introns. (thefreedictionary.com)
  • Most TCDD effects are mediated by its binding to the awl hydrocarbon receptor (AhR), leading to AhR nuclear translocation, heterodimerization with aryl hydrocarbon receptor nuclear translocator (ARNT), and binding to xenobiotic responsive elements present in the promoters of target genes (Barouki et al. (thefreedictionary.com)
  • 3/ hence, our objective is to identify key genes and mechanisms involved in FSHD oxidative stress and investigate whether natural antioxidant compounds administration might change the oxidative stress response in FSHD. (umontpellier.fr)
  • However, molecular mechanisms underlying the curious dependence of some cancer cells, which contain multiple genomic, genetic, and epigenetic abnormalities, on a single oncogenic molecule (the phenomenon of "oncogene addiction") are incompletely understood ( 3 - 5 ). (mcponline.org)
  • The objective of this study was to identify single-nucleotide polymorphisms using a bovine chromosome 14 high-density SNP panel after accounting for the effect of DGAT1. (biomedsearch.com)
  • These stages are described as a series of successive mutations that ultimately lead to malignant tumour growth [ 3 ]. (biomedcentral.com)
  • Health Details: Pronunciation of nicotinamide adenine dinucleotide with 2 audio pronunciations, 7 synonyms, 10 translations and more for nicotinamide adenine dinucleotide. (losangelesorienteering.org)
  • 3. The method of claim 1, wherein said applying said composition to said sample inhibits keratinocyte proliferation within said sample. (freepatentsonline.com)
  • The relationship of these parameters can be expressed by an equation solving for the 'reversal potential of the ANT" (Erev_ANT), a value of the mitochondrial membrane potential at which no net transport of adenine nucleotides takes place by the ANT. (wikipedia.org)
  • The adenine nucleotide translocator (ANT) has been suggested to be a principal component of the MPT pore and a possible target for DOX-induced cardiotoxicity. (elsevier.com)
  • Adenine definition is - a purine base C5H5N5 that codes hereditary information in the genetic code in DNA and RNA. (losangelesorienteering.org)
  • In a later study, oxidative stress was also reported to induce the MPT ( 3 ). (frontiersin.org)
  • Electrons (e − ) from carbon oxidations are transferred via NADH (nicotinamide adenine dinucleotide) into OXPHOS complex I, which is embedded in the lipid bilayer of the mitochondrial inner membrane (IMM), then transported to coenzyme Q (Q). Some electrons from organic‐acid oxidations are transferred, via other flavin‐containing enzyme complexes directly to CoQ. (els.net)
  • Because oxidative phosphorylation was not disturbed in fibroblasts and lymphocytes, we conclude that this patient suffers from a muscle-specific deficiency of his mitochondrial adenine nucleotide translocator, a defect unknown so far. (nature.com)
  • The adenine nucleotide translocator (ANT) transports ATP out of the mitochondrion. (thefreelibrary.com)
  • More research is warranted to better understand the pharmacokinetics of 3-BP, and its potential toxic effects to normal cells, in particular those that are highly ATP-/mitochondrion-dependent. (springer.com)
  • The aim of this research was to determine the sub-cellular location and hence provide information about possible functions of all the putative 3-ketoacyl-CoA thiolases (KAT) and acetoacetyl-CoA thiolases (ACAT) in Arabidopsis. (deepdyve.com)
  • The pyruvate mimetic 3-bromopyruvate (3-BP) is generally presented as an inhibitor of glycolysis and has shown remarkable efficacy in not only preventing tumor growth, but even eradicating existant tumors in animal studies. (springer.com)
  • The cytotoxicity of 3-BP is less due to pyruvate mimicry than to alkylation of, e.g., key thiols. (springer.com)
  • da Silva AP Pereira, El-Bacha T, Kyaw N, dos Santos RS, da-Silva WS, Almeida FC, Da Poian AT, Galina A (2009) Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate. (springer.com)
  • ABC transporters have a core structure consisting of two nucleotide binding domains (NBDs) and two transmembrane domains (TMDs). (biochemsoctrans.org)
  • We identified 3 novel heterozygous POLG1 substitutions in the same family. (cdc.gov)
  • Deficiencies have been found in all OXPHOS complexes, PDHc, the TCA cycle (3), and ANT. (thefreelibrary.com)
  • 1-3 Both hyperthyroidism and hypothyroidism produce changes in cardiac contractility, myocardial oxygen consumption, cardiac output, blood pressure, and systemic vascular resistance (SVR). (ahajournals.org)
  • 3. Bova S, Cargnelli G, D'Amato E, Forti S, Yang Q, Trevisi L, Debetto P, Cima L, Luciani S, Padrini R (1997) Calcium-antagonist effect of norbormide on isolated perfused heart and cardiac myocytes of guinea-pig: a comparison with verapamil. (unipd.it)
  • Although Pxa1/2p has been proposed to transport acyl-CoAs of different chain lengths [ 8 , 13 ], medium chain free (non-esterified) fatty acids are also imported into yeast peroxisomes via a parallel, ABC-independent route which requires the peroxisomal acyl-CoA synthetase (ACS), Faa2p and the adenine nucleotide translocator, Ant1p [ 8 , 14 , 15 ]. (biochemsoctrans.org)
  • In accordance, old rats showed an overexpression of the active fragment of caspases 3 and 9 in liver homogenates. (antiagingreports.com)
  • C57BL/6J mice (Mus musculus) have a mutant allele of nicotinamide nucleotide transhydrogenase (Nnt) that can act as a modifier. (escholarship.org)