AnatomyChemicals and DrugsPhenomena and ProcessesInformation Science
Adenine Nucleotide Translocator 1Mitochondrial ADP, ATP TranslocasesAdenine Nucleotide Translocator 2AtractylosideBongkrekic AcidAdenine NucleotidesAdenine Nucleotide Translocator 3Oxidative PhosphorylationMitochondriaMitochondria, LiverNucleotidyltransferasesIntracellular MembranesAdenosine DiphosphateAdenosine TriphosphateVoltage-Dependent Anion ChannelsMitochondrial Membrane Transport ProteinsMitochondrial SwellingMitochondria, HeartAdenineOxygen ConsumptionCyclophilinsMembrane Potential, MitochondrialUncoupling AgentsCell RespirationPermeabilityAryl Hydrocarbon Receptor Nuclear TranslocatorProto-Oncogene Proteins c-bcl-2Mitochondrial ProteinsNucleotidesMolecular Sequence DataApoptosisMembrane PotentialsKineticsDNA, MitochondrialAdenosine MonophosphateMyocardiumReceptors, GABAReceptors, Aryl HydrocarbonEnergy MetabolismPurine NucleotidesAmino Acid SequenceGuanine NucleotidesAdenosineBase SequenceHypoxanthines
Adenine Nucleotide Translocator 1
A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).
Mitochondrial ADP, ATP Translocases
A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization.
Adenine Nucleotide Translocator 2
A subtype of mitochondrial ADP, ATP translocase found primarily in FIBROBLASTS.
Atractyloside
A glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEPIS. Toxicity is due to inhibition of ADENINE NUCLEOTIDE TRANSLOCASE.
Bongkrekic Acid
An antibiotic produced by Pseudomonas cocovenenans. It is an inhibitor of MITOCHONDRIAL ADP, ATP TRANSLOCASES. Specifically, it blocks adenine nucleotide efflux from mitochondria by enhancing membrane binding.
Adenine Nucleotides
Adenine Nucleotide Translocator 3
A subtype of mitochondrial ADP, ATP translocase found primarily in the LIVER.
Oxidative Phosphorylation
Electron transfer through the cytochrome system liberating free energy which is transformed into high-energy phosphate bonds.
Mitochondria
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Mitochondria, Liver
Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)
Nucleotidyltransferases
A class of enzymes that transfers nucleotidyl residues. EC 2.7.7.
Intracellular Membranes
Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.
Adenosine Diphosphate
Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Adenosine Triphosphate
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Voltage-Dependent Anion Channels
A family of voltage-gated eukaryotic porins that form aqueous channels. They play an essential role in mitochondrial CELL MEMBRANE PERMEABILITY, are often regulated by BCL-2 PROTO-ONCOGENE PROTEINS, and have been implicated in APOPTOSIS.
Mitochondrial Membrane Transport Proteins
Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.
Mitochondrial Swelling
An increase in MITOCHONDRIAL VOLUME due to an influx of fluid; it occurs in hypotonic solutions due to osmotic pressure and in isotonic solutions as a result of altered permeability of the membranes of respiring mitochondria.
Mitochondria, Heart
The mitochondria of the myocardium.
Adenine
A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
Oxygen Consumption
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Cyclophilins
A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-
Membrane Potential, Mitochondrial
The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.
Uncoupling Agents
Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.
Cell Respiration
The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell.
Permeability
Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.
Aryl Hydrocarbon Receptor Nuclear Translocator
Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with DIOXIN RECEPTOR. The complex binds xenobiotic regulatory elements and activates transcription of a variety of genes including UDP GLUCURONOSYLTRANSFERASE. AhR nuclear translocator is also a subunit of HYPOXIA-INDUCIBLE FACTOR 1.
Proto-Oncogene Proteins c-bcl-2
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
Mitochondrial Proteins
Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.
Nucleotides
The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Membrane Potentials
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Kinetics
The rate dynamics in chemical or physical systems.
DNA, Mitochondrial
Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.
Adenosine Monophosphate
Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
Myocardium
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Receptors, GABA
Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.
Receptors, Aryl Hydrocarbon
Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.
Energy Metabolism
The chemical reactions involved in the production and utilization of various forms of energy in cells.
Purine Nucleotides
Purines attached to a RIBOSE and a phosphate that can polymerize to form DNA and RNA.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Guanine Nucleotides
Adenosine
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Hypoxanthines
Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.

Repression of the human adenine nucleotide translocase-2 gene in growth-arrested human diploid cells: the role of nuclear factor-1. (1/25)

Adenine nucleotide translocase-2 (ANT2) catalyzes the exchange of ATP for ADP across the mitochondrial membrane, thus playing an important role in maintaining the cytosolic phosphorylation potential required for cell growth. Expression of ANT2 is activated by growth stimulation of quiescent cells and is down-regulated when cells become growth-arrested. In this study, we address the mechanism of growth arrest repression. Using a combination of transfection, in vivo dimethyl sulfate mapping, and in vitro DNase I mapping experiments, we identified two protein-binding elements (Go-1 and Go-2) that are responsible for growth arrest of ANT2 expression in human diploid fibroblasts. Proteins that bound the Go elements were purified and identified by matrix-assisted laser desorption ionization time-of-flight mass spectrometry as members of the NF1 family of transcription factors. Chromatin immunoprecipitation analysis showed that NF1 was bound to both Go-1 and Go-2 in quiescent human diploid cells in vivo, but not in the same cells stimulated to growth by serum. NF1 binding correlated with the disappearance of ANT2 transcripts in quiescent cells. Furthermore, overexpression of NF1-A, -C, and -X in NIH3T3 cells repressed expression of an ANT2-driven reporter gene construct. Two additional putative repressor elements in the ANT2 promoter, an Sp1 element juxtaposed to the transcription start site and a silencer centered at nucleotide -332, did not appear to contribute to growth arrest repression. Thus, enhanced binding of NF1 is a key step in the growth arrest repression of ANT2 transcription. To our knowledge, this is the first report showing a role for NF1 in growth arrest.  (+info)

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. (2/25)

A sudden increase in permeability of the inner mitochondrial membrane, the so-called mitochondrial permeability transition, is a common feature of apoptosis and is mediated by the mitochondrial permeability transition pore (mtPTP). It is thought that the mtPTP is a protein complex formed by the voltage-dependent anion channel, members of the pro- and anti-apoptotic BAX-BCL2 protein family, cyclophilin D, and the adenine nucleotide (ADP/ATP) translocators (ANTs). The latter exchange mitochondrial ATP for cytosolic ADP and have been implicated in cell death. To investigate the role of the ANTs in the mtPTP, we genetically inactivated the two isoforms of ANT in mouse liver and analysed mtPTP activation in isolated mitochondria and the induction of cell death in hepatocytes. Mitochondria lacking ANT could still be induced to undergo permeability transition, resulting in release of cytochrome c. However, more Ca2+ than usual was required to activate the mtPTP, and the pore could no longer be regulated by ANT ligands. Moreover, hepatocytes without ANT remained competent to respond to various initiators of cell death. Therefore, ANTs are non-essential structural components of the mtPTP, although they do contribute to its regulation.  (+info)

Identification of NF1 as a silencer protein of the human adenine nucleotide translocase-2 gene. (3/25)

The human adenine nucleotide translocase-2 (ANT2) promoter contains a silencer region that confers partial repression on the heterologous herpes simplex virus thymidine kinase (HSVtk) promoter [Barath, P., Albert-Fournier, B., Luciakova, K., Nelson, B.D. (1999) J. Biol. Chem.274, 3378-3384]. Two sequences in the silencer (Site-2 and Site-3) are protected in the DNase I assay in vitro, and one of these is a repeated GTCCTG element previously shown to act as the active repressor element. We have now purified the DNA binding protein, and identified it using MALDI-TOF MS as a 33-kDa member of the nuclear factor 1 (NF1) family of transcription factors. NF1 purified from rat liver and HeLa cell nuclei bind to both silencer Site-2 and Site-3, resulting in a DNase I footprint identical to that obtained with purified recombinant NF1. Furthermore, transient transfection experiments with reporter constructs containing mutated silencer Site-2 and/or Site-3 show that both sites contribute to repression of the HSVtk promoter. Finally, chromatin immunoprecipitation analysis reveals that NF1 is bound to both elements on the endogenous HeLa cell ANT2 promoter. Our data support the belief that NF1 acts as a repressor when bound to silencing Site-2 and Site-3 of the ANT2 gene.  (+info)

Recruitment of NF-kappaB into mitochondria is involved in adenine nucleotide translocase 1 (ANT1)-induced apoptosis. (4/25)

Overexpression of adenine nucleotide translocase-1 (ANT1) is known to induce apoptosis (Bauer, M. K., Schubert, A., Rocks, O., and Grimm, S. (1999) J. Cell Biol. 147, 1493-1501), but the mechanisms involved remain unclear. In this study we show that ANT1 overexpression results in a recruitment of the IkappaBalpha-NF-kappaB complex into mitochondria, with a coincident decrease in nuclear NF-kappaB DNA binding activity. In this situation, NF-kappaB transcriptionally regulated genes with antiapoptotic activity, such as Bcl-XL, MnSOD2, and c-IAP2, are down-regulated, and consequently, cells are sensitized to apoptosis. Accordingly, co-expression of p65 partially interferes with the proapoptotic effect of ANT1 overexpression. Despite the high identity of the two isoforms, overexpression of ANT2 does not exert an apoptotic effect; this lack of apoptotic activity is correlated with the absence of mitochondrial IkappaBalpha-NF-kappaB recruitment or changes in NF-kappaB activity. Thus, we propose that the mitochondrial recruitment of NF-kappaB observed following ANT1 overexpression has an important role in ANT1 proapoptotic activity.  (+info)

Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively. (5/25)

In brown-fat mitochondria, fatty acids induce thermogenic uncoupling through activation of UCP1 (uncoupling protein 1). However, even in brown-fat mitochondria from UCP1-/- mice, fatty-acid-induced uncoupling exists. In the present investigation, we used the inhibitor CAtr (carboxyatractyloside) to examine the involvement of the ANT (adenine nucleotide translocator) in the mediation of this UCP1-independent fatty-acid-induced uncoupling in brown-fat mitochondria. We found that the contribution of ANT to fatty-acid-induced uncoupling in UCP1-/- brown-fat mitochondria was minimal (whereas it was responsible for nearly half the fatty-acid-induced uncoupling in liver mitochondria). As compared with liver mitochondria, brown-fat mitochondria exhibit a relatively high (UCP1-independent) basal respiration ('proton leak'). Unexpectedly, a large fraction of this high basal respiration was sensitive to CAtr, whereas in liver mitochondria, basal respiration was CAtr-insensitive. Total ANT protein levels were similar in brown-fat mitochondria from wild-type mice and in liver mitochondria, but the level was increased in brown-fat mitochondria from UCP1-/- mice. However, in liver, only Ant2 mRNA was found, whereas in brown adipose tissue, Ant1 and Ant2 mRNA levels were equal. The data are therefore compatible with a tentative model in which the ANT2 isoform mediates fatty-acid-induced uncoupling, whereas the ANT1 isoform may mediate a significant part of the high basal proton leak in brown-fat mitochondria.  (+info)

Chemosensitization by knockdown of adenine nucleotide translocase-2. (6/25)

Mitochondrial membrane permeabilization (MMP) is a rate-limiting step of apoptosis, including in anticancer chemotherapy. Adenine nucleotide translocase (ANT) mediates the exchange of ADP and ATP on the inner mitochondrial membrane in healthy cells. In addition, ANT can cooperate with Bax to form a lethal pore during apoptosis. Humans possess four distinct ANT isoforms, encoded by four genes, whose transcription depends on the cell type, developmental stage, cell proliferation, and hormone status. Here, we show that the ANT2 gene is up-regulated in several hormone-dependent cancers. Knockdown of ANT2 by RNA interference induced no major changes in the aspect of the mitochondrial network or cell cycle but provoked minor increase in mitochondrial transmembrane potential and reactive oxygen species level and reduced intracellular ATP concentration without affecting glycolysis. At expression and functional levels, ANT2 depletion was not compensated by other ANT isoforms. Most importantly, ANT2, but not ANT1, silencing facilitated MMP induction by lonidamine, a mitochondrion-targeted antitumor compound already used in clinical studies for breast, ovarian, glioma, and lung cancer as well as prostate adenoma. The combination of ANT2 knockdown with lonidamine induced apoptosis irrespective of the Bcl-2 status. These data identify ANT2 as an endogenous inhibitor of MMP and suggest that its selective inhibition could constitute a promising strategy of chemosensitization.  (+info)

Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription: evidence for the participation of Smad and Sp family proteins in the NF1-dependent repressor complex. (7/25)

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Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo. (8/25)

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Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility...Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility...
The four known human ANT isoforms (ANT1, ANT2, ANT3, and ANT4) exhibit tissue-, cell-type-, and developmental stage-specific expression patterns [18]. ANT1 is strongly expressed in terminally differentiated cells; ANT2 is overexpressed in tissues that have high proliferative ability and in several cancer cell lines [16, 21]; and ANT3 is ubiquitously expressed in all tissues. Whereas ANT1 and ANT3 exert pro-apoptotic effects when overexpressed, ANT2, instead, has an anti-apoptotic function [20, 28]. We previously observed that ANT2 is overexpressed in the breast cancer cell lines MCF7 and MDA-MB-231 but is absent from the non-neoplastic mammary epithelial cell line MCF10A [16]. Moreover, vector-based RNAi knockdown of ANT2 expression in MCF7 and MDA-MB-231 cells resulted in cell cycle arrest and apoptotic cell death; these events were accompanied by cellular energy (ATP) depletion, mitochondrial membrane depolarization, Bax induction, and Bcl-xL down-regulation [16]. TNF-α and TNF receptor I ...
https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-9-262
Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2...Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2...
In brown-fat mitochondria, fatty acids induce thermogenic uncoupling through activation of UCP1 (uncoupling protein 1). However, even in brown-fat mitochondria from UCP1−/− mice, fatty-acid-induced uncoupling exists. In the present investigation, we used the inhibitor CAtr (carboxyatractyloside) to examine the involvement of the ANT (adenine nucleotide translocator) in the mediation of this UCP1-independent fatty-acid-induced uncoupling in brown-fat mitochondria. We found that the contribution of ANT to fatty-acid-induced uncoupling in UCP1−/− brown-fat mitochondria was minimal (whereas it was responsible for nearly half the fatty-acid-induced uncoupling in liver mitochondria). As compared with liver mitochondria, brown-fat mitochondria exhibit a relatively high (UCP1-independent) basal respiration (proton leak). Unexpectedly, a large fraction of this high basal respiration was sensitive to CAtr, whereas in liver mitochondria, basal respiration was CAtr-insensitive. Total ANT protein ...
https://portlandpress.com/biochemj/article-abstract/399/3/405/41792/Carboxyatractyloside-effects-on-brown-fat
Recent Publications | Medicinal Chemistry Faculty ResearchRecent Publications | Medicinal Chemistry Faculty Research
Zhang, Y.; Matsuyama, H.; Shiratsuchi, T.; Tian, D.; Hook, D. J.; Walters, M. A.; Georg, G. I.; Hawkinson, J. E.; Hamazaki, T.; Terada, N. Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast. J Biomol Screen 2016.. Kurbanov, E. K.; Chiu, T.-L.; Solberg, J.; Francis, S.; Maize, K. M.; Fernandez, J.; Johnson, R. L.; Hawkinson, J. E.; Walters, M. A.; Finzel, B. C.; Amin, E. A. Probing the S2 Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates. J. Med. Chem. 2015, 58, 8723-8733.. Dahlin, J. L.; Nissink, J. W. M.; Strasser, J. M.; Francis, S.; Higgins, L.; Zhou, H.; Zhang, Z.; Walters, M. A. PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS. J. Med. Chem. 2015, 58, 2091-2113.. Dahlin, J. L.; Nissink, J. W. M.; Francis, S.; Strasser, J. M.; John, K.; Zhang, Z.; Walters, M. A. Post-HTS case report and structural alert: ...
http://www.medicinal-chemistry.org/walters/publications
FAM96B - Mitotic spindle-associated MMXD complex subunit MIP18 - Homo sapiens (Human) - FAM96B gene & proteinFAM96B - Mitotic spindle-associated MMXD complex subunit MIP18 - Homo sapiens (Human) - FAM96B gene & protein
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD.
http://www.uniprot.org/uniprot/Q9Y3D0
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https://www.cyklodresy.sk/cyklo-oblecenie/bundy/six2-mant-w-bunda-transparent-blue
Agent Orange Zone: October 2016Agent Orange Zone: October 2016
Monsanto began in 1901. Its first product was saccharin, made from toluene and petroleum. In 1977, the FDA moved to ban the use of saccharin in prepared foods after testing showed that it could cause bladder cancer. Congress rejected the FDAs request and instead agreed that manufacturers would provide health warnings on their packaging. In the 1920s, Monsanto began producing pesticides and herbicides, including what came to be known of as Agent Orange. Agent Orange is a defoliant made from 2,4-D and 2,4-T. It was used extensively in Vietnam by the US armed forces during the Vietnam War. The Vietnam Veterans of America lists at least fifty illnesses and diseases and nearly twenty separate birth defects connected to exposure to Agent Orange. Agent Orange is the gift that keeps on giving, as to this day, children in Vietnam are born with ghastly birth defects and nervous disorders. During the 1930s, Monsanto began manufacturing polychlorinated biphenyls (PCBs). PCBs are so toxic that they were ...
http://agentorangezone.blogspot.com/2016/10/
Adenine nucleotide translocator synonyms, Adenine nucleotide translocator antonyms - FreeThesaurus.comAdenine nucleotide translocator synonyms, Adenine nucleotide translocator antonyms - FreeThesaurus.com
Synonyms for Adenine nucleotide translocator in Free Thesaurus. Antonyms for Adenine nucleotide translocator. 1 synonym for adenine: A. What are synonyms for Adenine nucleotide translocator?
https://www.freethesaurus.com/Adenine+nucleotide+translocator
Selleck Chemicals Blog-Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cellsSelleck Chemicals Blog-Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells
The colorectal cancer (CRC) is one leading contributor of cancer-related mortality worldwide. The search for effective anti-CRC agents is valuable. In the current study, we showed that icaritin (ICT), an active natural ingredient from the Chinese plant Epimedium, potently inhibited proliferation and survival of established (HT-29, HCT-116, DLD-1, and SW-620) and primary (patient-derived) CRC cells. Significantly, ICT mainly induced necrosis, but not apoptosis, in CRC cells. The necrosis inhibitor necrostatin-1 attenuated ICT-mediated cytotoxicity in CRC cells. We showed that ICT treatment in CRC cells induced mitochondrial permeability transition pore (mPTP) opening, which was evidenced by mitochondrial membrane potential (MMP) decrease and mitochondrial adenine nucleotide translocator-1 (ANT-1)-cyclophilin-D (CyPD) association. On the other hand, mPTP blockers, including sanglifehrin A, cyclosporin A, and bongkrekic acid, as well as siRNA-mediated knockdown of mPTP component (CyPD or ANT-1), ...
https://www.selleckchem.com/blog/Icaritin-activates-JNK-dependent-mPTP-necrosis-pathway-in-colorecta-cancer-cells.html?pathway=logical_ER_stress_UPR
Adenine Nucleotide Translocator 1 Summary Report | CureHunterAdenine Nucleotide Translocator 1 Summary Report | CureHunter
Adenine Nucleotide Translocator 1: A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).
http://www.curehunter.com/public/keywordSummaryD033741-Adenine-Nucleotide-Translocator-1.do
Slc25a13 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 ...
Slc25a13 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 (Slc25a13), nuclear gene encoding mitochondrial protein, transcript variant 1, (10ug), 10 µg.
https://www.acris-antibodies.com/cdna/mouse-cdna/slc25a13-untagged-mouse-solute-carrier-family-25-mitochondrial-carrier-adenine-nucleotide-translocator-member-13-slc25a13-nuclear-gene-encoding-mitochondrial-protein-transcript-variant-1-10ug-mc220340.htm
Slc25a4 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 (cDNA...
Slc25a4 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 (cDNA clone, (10ug), 10 µg.
https://www.acris-antibodies.com/cdna/mouse-cdna/slc25a4-untagged-mouse-solute-carrier-family-25-mitochondrial-carrier-adenine-nucleotide-translocator-member-4-cdna-clone-10ug-mc218137.htm
Anti-Adenine Nucleotide Translocator 2 antibody (ab118125)Anti-Adenine Nucleotide Translocator 2 antibody (ab118125)
Rabbit polyclonal Adenine Nucleotide Translocator 2 antibody validated for WB, IP and tested in Human. With 2 independent reviews. Immunogen corresponding to…
http://www.abcam.com/adenine-nucleotide-translocator-2-antibody-ab118125.html
Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) |...Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) |...
Diabetes increases myocardial FA oxidation and MVO2, but underlying mechanisms are partially understood. We used perfused hearts, permeabilized fibers (fibers) and isolated mitochondria from diabetic db/db mice to assess mitochondrial (MITO) uncoupling and to elucidate underlying molecular mechanisms. MITO uncoupling and reduced cardiac efficiency (CE) was absent in hearts perfused with glucose alone. However, in db/db hearts perfused with 1.0 mM Palmitate and 11mM glucose, RPP was reduced by 31% p, 0.02, MVO2 was increased by 45% p, 0.03, and CE reduced by 51% p,0.004. In fibers, state 3 respirations with palmitoyl carnitine were similar (16.4±1.3 and 16.7±1.5 nmol/min/mg), but ATP production rates were reduced by 36% in db/db fibers so that ATP/O ratios were 1.5±0.2 in db/db vs. 2.5±0.1 in controls (p,0.005), indicating FA-induced mitochondrial uncoupling. H2O2 production was also increased by 2.6 fold (p,0.001) in isolated db/db MITO exposed to the complex 1 substrate pyruvate. To ...
http://circ.ahajournals.org/content/114/Suppl_18/II_244.5
anti-SLC25A31 antibody | GeneTexanti-SLC25A31 antibody | GeneTex
SLC25A31 antibody (solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31) for ELISA, WB. Anti-SLC25A31 pAb (GTX87816) is tested in Human, Mouse samples. 100% Ab-Assurance.
http://www.genetex.com/SLC25A31-antibody-GTX87816.html
SLC25A5 - ADP/ATP translocase 2 - Homo sapiens (Human) - SLC25A5 gene & proteinSLC25A5 - ADP/ATP translocase 2 - Homo sapiens (Human) - SLC25A5 gene & protein
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
https://www.uniprot.org/uniprot/P05141
são essenciais para mantsão essenciais para mant
são essenciais para mant expressa antígenos alogênicos paternos, depende de mecanismos que atuam localmente na interface materno-fetal
https://www.yumpu.com/pt/document/view/59831176/abbas-8ed-imunologia-celular-e-molecular/723
Activities : Health and Medicine DivisionActivities : Health and Medicine Division
This report is the final of the Veterans and Agent Orange series, which was required by Public Law 102-4, The Agent Orange Act of 1991, and extended by Public Law 107-103. The Secretary of Veterans Affairs was directed to contract with the National ...
http://www.nationalacademies.org/hmd/Activities.aspx?board1=%7BAA6A9D39-391C-4D81-BCCD-B21C08C2746C%7D&topic1=%7BFDC446A2-D451-4DED-AEA0-A1DBCAD346E7%7D
Adenine nucleotide translocator 1 | definition of adenine nucleotide translocator 1 by Medical dictionaryAdenine nucleotide translocator 1 | definition of adenine nucleotide translocator 1 by Medical dictionary
Looking for online definition of adenine nucleotide translocator 1 in the Medical Dictionary? adenine nucleotide translocator 1 explanation free. What is adenine nucleotide translocator 1? Meaning of adenine nucleotide translocator 1 medical term. What does adenine nucleotide translocator 1 mean?
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Mitochondriales TRNG-Gen
Graham BH et al. (1997) A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator.. [^] ...
http://www.moldiag.com/moldiag/de/id/G0325
Henry Weber - Crèmant D Alsace Ml. 750 Buy Online.Henry Weber - Crèmant D Alsace Ml. 750 Buy Online.
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Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2...Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2...
AIMS: In this study we investigated whether attenuation of endoplasmic reticulum stress (ER stress) could protect HepG2 cells from free fatty acid (FFA)-induced apoptosis. MAIN METHODS: Human liver cell line HepG2 cells were exposed to Sodium Palmitate (Pa) or Sodium Oleate (Ol). Apoptosis and ER stress of HepG2 cells were analyzed with flow cytometry, real-time RT-PCR and Western Blotting. An expression plasmid encoding for the ER chaperone immunoglobulin heavy chain-binding protein (Bip) was transfected into HepG2 cells to attenuate ER stress. Small interfering RNA siCHOP was used to knockdown the expression of C/EBP Homologous Protein (CHOP) in HepG2. KEY FINDINGS: Pa led to cytotoxicity and apoptosis in HepG2 cells in a dose-dependent pattern and also induced ER stress indicated by increased phosphorylation of eIF2alpha, upregulation of IRE1alpha and CHOP. Bip expression levels were slightly down regulated after Pa treatment. The unsaturated fatty acid, Ol, induced neither apoptosis nor ER stress in
https://www.garvan.org.au/research/publications/10884
Fatty-acid-induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is...Fatty-acid-induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is...
Both cis and trans unsaturated fatty acids and sodium dodecyl sulfate activated NADPH oxidase in plasma membranes of human neutrophils in the presence of neutrophil cytosol. In contrast, 5,8,11,14-icosatetraynoic acid, saturated fatty acids, esters, peroxides and 4 beta-phorbol 12-myristate 13-acetate, a potent activator of protein kinase C, were inactive. 5,8,11,14-icosatetraynoic acid inhibited superoxide formation elicited by fatty acids. Guanosine 5[gamma-thio]triphosphate (GTP[gamma S]), a potent activator of guanine-nucleotide-binding proteins (N-proteins) enhanced superoxide formation elicited by fatty acids up to fourfold, supporting our previous suggestion that NADPH oxidase is regulated by an N-protein [Seifert, R. et al. (1986) FEBS Lett. 205, 161-165]. Cytosols from various tissues, soybean lipoxygenase and protein kinase C, purified from chicken stomach, did not substitute neutrophil cytosol. The activity of neutrophil cytosol was destroyed by heating at 95 degrees C. Superoxide ...
https://epub.uni-regensburg.de/23273/
Kafayı Çalıştır Seti (Orta Seviye) - ANT StoresKafayı Çalıştır Seti (Orta Seviye) - ANT Stores
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OriGene - APRT (NM 000485) Human ORF cDNA CloneOriGene - APRT (NM 000485) Human ORF cDNA Clone
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http://www.origene.com/orf_clone/trueclone/NM_000485/RC216874/APRT.aspx
Obra L., Mant. Pl. Altera (1771) Mantissa Plantarum Altera [hoseito.com]Obra L., Mant. Pl. Altera (1771) Mantissa Plantarum Altera [hoseito.com]
Ficha original de Obra L., Mant. Pl. Altera (1771) Mantissa Plantarum Altera, con propiedad y copyright de la web www.hoseito.com.
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Download Klasik Mantık 1986Download Klasik Mantık 1986
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Esté atento. Manténgase informado de la predicción meteorológica más actualizada. Algunas actividades al aire libre pueden verse alteradas ...
https://www.meteoalarm.eu/sr_ME/0/0/ES-Spanien.html
Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1
Our data show that gAcrp30 partially rescues beta cells from cytokine- and fatty-acid-induced apoptosis and completely restores autoimmune- and lipotoxicity-induced dysfunction of insulin-producing cells. We suggest that gAcrp30 exerts its anti-apoptotic function without modulating NF-kappaB activat …
https://pubmed.ncbi.nlm.nih.gov/14722646/?dopt=Abstract
We have beforehand claimed that glutamate and the adenine nucleotide translocase inhibitor, carboxyatractyloside, ameliorate...
Mant Mask | Dont Starve Wiki | FandomMant Mask | Dont Starve Wiki | Fandom
Exclusive to: Hamlet. The Mant Mask is a craftable Armor Item exclusive to the Hamlet DLC. It is found in the Fight Tab. It requires 5 Chitin and 1 Football Helmet to craft, and a Science Machine to prototype. When worn along with a Mant Suit, it allows the player to disguise among the Mants and...
https://dontstarve.fandom.com/wiki/Mant_Mask
Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cellsTargeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells
The HIV-1 encoded apoptogenic protein Vpr induces mitochondrial membrane permeabilization (MMP) via interactions with the voltage-dependent anion channel (VDAC) and the adenine nucleotide translocator (ANT). We have designed a peptide, TEAM-VP, composed of two functional domains, one a tumor blood v …
https://pubmed.ncbi.nlm.nih.gov/16888644/
OXPHOS - Adenine Nucleotide Assays and Issues
OXPHOS - this site is dedicated to mitochondria research. Theoretical and practical aspects, reagents, protocols, tools, funding agencies, databases, conferences, etc.
http://oxphos.net/index.php?option=com_content&task=view&id=93&Itemid=1
Hepatic Adenine Nucleotides and DNA Synthesis during the Regenerative and Atrophic Process of the Liver Lobes after Selective...Hepatic Adenine Nucleotides and DNA Synthesis during the Regenerative and Atrophic Process of the Liver Lobes after Selective...
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Elden Selections - Picamelot Cremant de Bourgogne Rose 2018Elden Selections - Picamelot Cremant de Bourgogne Rose 2018
This Crémant de Bourgogne is made with hand-picked grapes coming from the Côte Chalonnaise and the Côte de Beaune, and 100% from the pinot noir grape variety.
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Associated Effluxes of Calcium and Adenine Nucleotides from Mitochondria: Mediation by Thyroxine and other Agents, and...Associated Effluxes of Calcium and Adenine Nucleotides from Mitochondria: Mediation by Thyroxine and other Agents, and...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.biochemsoctrans.org/content/7/1/215
OriGene - WDHD1 (NM 001008396) shRNAOriGene - WDHD1 (NM 001008396) shRNA
WDHD1 - WDHD1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector shRNA available for purchase from OriGene - Your Gene Company.
http://www.origene.com/shRNA/TF308385.aspx
Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase<...
TY - JOUR. T1 - Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase. AU - Nadtochiy, Sergiy M.. AU - Zhu, Qiuyu. AU - Urciuoli, William. AU - Rafikov, Ruslan. AU - Black, Stephen M.. AU - Brookes, Paul S.. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2012/1/27. Y1 - 2012/1/27. N2 - Electrophilic nitrated lipids (nitroalkenes) are emerging as an important class of protective cardiovascular signaling molecules. Although species such as nitro-linoleate (LNO 2) and nitro-oleate can confer acute protection against cardiac ischemic injury, their mechanism of action is unclear. Mild uncoupling of mitochondria is known to be cardioprotective, and adenine nucleotide translocase 1 (ANT1) is a key mediator of mitochondrial uncoupling. ANT1 also contains redox-sensitive cysteines that may be targets for modification by nitroalkenes. Therefore, in this study we tested the hypothesis that nitroalkenes directly modify ANT1 and that nitroalkene-mediated ...
https://augusta.pure.elsevier.com/en/publications/nitroalkenes-confer-acute-cardioprotection-via-adenine-nucleotide
Modeling of ATP-ADP steady-state exchange rate mediated by the adenine nucleotide translocase in isolated mitochondria -...Modeling of ATP-ADP steady-state exchange rate mediated by the adenine nucleotide translocase in isolated mitochondria -...
A computational model for the ATP-ADP steady-state exchange rate mediated by adenine nucleotide translocase (ANT) versus mitochondrial membrane potential dependence in isolated rat liver mitochondria is presented. The model represents the system of three ordinary differential equations, and the basic components included are ANT,...
http://scipeople.ru/publication/67177/
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Adenine nucleotide translocatorAdenine nucleotide translocator
Adenine+Nucleotide+Translocator+1 at the US National Library of Medicine Medical Subject Headings (MeSH) Adenine+Nucleotide+ ... Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or ... Pressman BC (June 1958). "Intramitochondrial nucleotides. I. Some factors affecting net interconversions of adenine nucleotides ... Adenine+Nucleotide+Translocator+3 at the US National Library of Medicine Medical Subject Headings (MeSH) (Articles with short ...
https://en.wikipedia.org/wiki/Adenine_nucleotide_translocator
Bcl-2-associated X proteinBcl-2-associated X protein
"Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science. 281 (5385): 2027-31. ... Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains ... Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. BAX is a ... Bcl-2-associated X protein has been shown to interact with: Bcl-2, BCL2L1, BCL2A1 SH3GLB1, SLC25A4, VDAC1, TCTP, YWHAQ, Bid, ...
https://en.wikipedia.org/wiki/Bcl-2-associated_X_protein
CYC1CYC1
"Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR ... Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T (April 1988). "Nucleotide sequence of a cDNA ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Valnot I, Kassis J, Chretien D, de Lonlay P, Parfait B, ... 19 (2): 400-1. doi:10.1006/geno.1994.1084. PMID 8188279. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S ( ...
https://en.wikipedia.org/wiki/CYC1
AGK (gene)AGK (gene)
AGK also has an implicated role in the assembly of the adenine nucleotide translocator in the inner mitochondrial membrane. ... ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate. The enzyme is involved in the more general pathway of ... 90 (2): 314-20. doi:10.1016/j.ajhg.2011.12.005. PMC 3276657. PMID 22284826. Aldahmesh MA, Khan AO, Mohamed JY, Alghamdi MH, ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano ...
https://en.wikipedia.org/wiki/AGK_(gene)
Jerzy Duszyński (biochemist)Jerzy Duszyński (biochemist)
1982). "Quantification of the role of the adenine nucleotide translocator in the control of mitochondrial respiration in ... The first quantification of the controlling weight of adenine nucleotide transport in cellular bioenergetics. Quantification of ... 146 (2): 262-266. doi:10.1016/0014-5793(82)80931-9. PMID 6291990. Wojtczak, L.; et al. (1986). "Energy storage capacity of the ... 851 (2): 313-321. doi:10.1016/0005-2728(86)90138-6. PMID 3741850. Zabłocki, K.; et al. (2005). "Extracellular pH modifies ...
https://en.wikipedia.org/wiki/Jerzy_Duszyński_(biochemist)
MitochondrionMitochondrion
ROS increases uncoupling proteins (UCPs) and potentiate proton leakage through the adenine nucleotide translocator (ANT), the ... One of the two mitochondrial DNA (mtDNA) strands has a disproportionately higher ratio of the heavier nucleotides adenine and ... Nachman MW, Crowell SL (September 2000). "Estimate of the mutation rate per nucleotide in humans". Genetics. 156 (1): 297-304. ... Tumor cells require ample ATP to synthesize bioactive compounds such as lipids, proteins, and nucleotides for rapid ...
https://en.wikipedia.org/wiki/Mitochondrion
BCL2L13BCL2L13
Kim JY, So KJ, Lee S, Park JH (Sep 2012). "Bcl-rambo induces apoptosis via interaction with the adenine nucleotide translocator ... Bcl-rambo mediates apoptosis by associating with adenine nucleotide translocator (ANT), a component of the mitochondrial ... Kataoka T, Holler N, Micheau O, Martinon F, Tinel A, Hofmann K, Tschopp J (Jun 2001). "Bcl-rambo, a novel Bcl-2 homologue that ... In addition to these domains, it has conserved B-cell lymphoma 2 homology motifs, as well as an extension at its c-terminal, ...
https://en.wikipedia.org/wiki/BCL2L13
MT-TTMT-TT
... myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator". ... MT-TT is a small 66 nucleotide RNA (human mitochondrial map position 15888-15953) that transfers the amino acid threonine to a ... 2 (2): 121-7. doi:10.1007/s100480050063. PMID 10369889. S2CID 13031885. Yoon KL, Aprille JR, Ernst SG (May 1991). " ...
https://en.wikipedia.org/wiki/MT-TT
Substrate-level phosphorylationSubstrate-level phosphorylation
... but also to prevent mitochondria from straining glycolytic ATP reserves by maintaining the adenine nucleotide translocator in ' ... "Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level ... "Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues". The Journal of ... 2 molecules of NADH are also produced and can be used in oxidative phosphorylation to generate more ATP. ATP can be generated ...
https://en.wikipedia.org/wiki/Substrate-level_phosphorylation
List of MeSH codes (D12.776)List of MeSH codes (D12.776)
... adenine nucleotide translocator 1 MeSH D12.776.575.750.500.200 - adenine nucleotide translocator 2 MeSH D12.776.575.750.500.300 ... adenine nucleotide translocator 3 MeSH D12.776.580.210.175.325 - groes protein MeSH D12.776.580.210.180.325 - groel protein ... cofilin 2 MeSH D12.776.220.525.212.875 - destrin MeSH D12.776.220.525.246.500 - actin-related protein 2 MeSH D12.776.220.525. ... iron regulatory protein 2 MeSH D12.776.556.579.374.375.863 - electron transport complex i MeSH D12.776.556.579.374.375.863.500 ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
List of MeSH codes (D12.776.157)List of MeSH codes (D12.776.157)
... adenine nucleotide translocator 1 MeSH D12.776.157.530.625.875.500.200 - adenine nucleotide translocator 2 MeSH D12.776.157.530 ... 500.300 - adenine nucleotide translocator 3 MeSH D12.776.157.530.750.100 - aryl hydrocarbon receptor nuclear translocator MeSH ... nucleotide transport proteins MeSH D12.776.157.530.625.875.500 - mitochondrial adp, atp translocases MeSH D12.776.157.530. ... MeSH D12.776.157.057.030.124 - interferon regulatory factor-1 MeSH D12.776.157.057.030.249 - interferon regulatory factor-2 ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.157)
Membrane transport proteinMembrane transport protein
Adenine nucleotide translocator (ANT) 2.B: Nonribosomally synthesized porters, such as: The Nigericin family The Ionomycin ... such as rhodopsin The group translocators provide a special mechanism for the phosphorylation of sugars as they are transported ... 116 (2): 164-176. doi:10.1111/j.1471-4159.2010.07109.x. PMC 3005101. PMID 21073468. Scholze P, Nørregaard L, Singer EA, ... 2.A: Porters (uniporters, symporters, antiporters), SLCs. Excitatory amino acid transporters (EAATs) EAAT1 EAAT2 EAAT3 EAAT4 ...
https://en.wikipedia.org/wiki/Membrane_transport_protein
Y linkageY linkage
... adenine nucleotide translocator-3 on the Y), AZF2 (azoospermia factor 2), BPY2 (basic protein on the Y chromosome), AZF1 ( ... 92 (2): 301-6. doi:10.1016/j.ajhg.2012.12.015. PMC 3567277. PMID 23352258. Postma, Erik (2011). "Sex-Dependent Selection ... RNA binding motif protein 2), and UTY (ubiquitously transcribed TPR gene on Y chromosome). USP9Y AMELY Genetic linkage Sex ...
https://en.wikipedia.org/wiki/Y_linkage
List of MeSH codes (D12.776.543)List of MeSH codes (D12.776.543)
... adenine nucleotide translocator 1 MeSH D12.776.543.585.450.162.235.200 - adenine nucleotide translocator 2 MeSH D12.776.543.585 ... adenine nucleotide translocator 1 MeSH D12.776.543.585.625.875.500.200 - adenine nucleotide translocator 2 MeSH D12.776.543.585 ... 500.300 - adenine nucleotide translocator 3 MeSH D12.776.543.585.750.100 - aryl hydrocarbon receptor nuclear translocator MeSH ... 235.300 - adenine nucleotide translocator 3 MeSH D12.776.543.585.450.162.276 - potassium-hydrogen antiporters MeSH D12.776. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.543)
ApoptosomeApoptosome
... the inner membrane protein adenine nucleotide translocator (AdNT) and the matrix protein cyclophilin D (CyD) (12). This pore ... It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. ... A short linker and nucleotide binding a/b domains (NBD) that contain conserved Walker boxes A (p-loop 155-161) and B (239-243) ... Another model proposes that Apaf-1 is organized in an extended fashion such that both the N-terminal CARD and the nucleotide ...
https://en.wikipedia.org/wiki/Apoptosome
TXN2TXN2
... thiols in the mitochondrial permeability transition pore component adenine nucleotide translocator (ANT). Overexpression of ... "Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer". Cancer Research. ... 66 (2): 1225-33. doi:10.1158/0008-5472.CAN-05-1857. PMID 16424062. Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, ... Wen S, Lu W, Zhu H, Yang W, Shaw GM, Lammer EJ, Islam A, Finnell RH (Feb 2009). "Genetic polymorphisms in the thioredoxin 2 ( ...
https://en.wikipedia.org/wiki/TXN2
Sengers syndromeSengers syndrome
The SLC25A4 gene encodes the heart and muscle-specific isoform 1 of the mitochondrial adenine nucleotide translocator. The ... AGK gene encodes the mitochondrial acylglycerol kinase which plays a role in the assembly of adenine nucleotide translocator. ... Marked lactic acidemia occurs with even limited muscular exertion.[citation needed] 2.The chronic form, which has stable ...
https://en.wikipedia.org/wiki/Sengers_syndrome
ARHGAP11BARHGAP11B
... where it binds to the adenine nucleotide translocator. It does not affect the adenine nucleotide exchange activity of the ... A 2016 study suggests, one mutation, a "single nucleotide substitution underlies the specific properties of ARHGAP11B that ... translocator, but it does lead to delayed opening of the mitochondrial permeability transition pore, thus allowing for greater ... 2 (12): e1601941. Bibcode:2016SciA....2E1941F. doi:10.1126/sciadv.1601941. PMC 5142801. PMID 27957544. Sudmant PH, Kitzman JO, ...
https://en.wikipedia.org/wiki/ARHGAP11B
ThermogeninThermogenin
UCP1 is very similar to the ATP/ADP Carrier protein, or Adenine Nucleotide Translocator (ANT). The proposed alternating access ... UCP1 is related to other mitochondrial metabolite transporters such as the adenine nucleotide translocator, a proton channel in ... UCP1 is activated in the brown fat cell by fatty acids and inhibited by nucleotides. Fatty acids are released by the following ... overriding the inhibition caused by purine nucleotides (GDP and ADP). During the termination of thermogenesis, thermogenin is ...
https://en.wikipedia.org/wiki/Thermogenin
Mitochondrial carrierMitochondrial carrier
SLC25A25 adenine nucleotide - SLC25A4, SLC25A5, SLC25A6, SLC25A31 dicarboxylate - SLC25A10 oxoglutarate - SLC25A11 glutamate - ... "Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential". Journal ... Mitochondrial carriers transport amino acids, keto acids, nucleotides, inorganic ions and co-factors through the mitochondrial ... nucleotides, amino acids, keto acids and cofactors across the membrane. Such proteins include: ADP/ATP carrier protein (ADP-ATP ...
https://en.wikipedia.org/wiki/Mitochondrial_carrier
Mitochondrial permeability transition poreMitochondrial permeability transition pore
Further hypothesis by Halestrap's group convincingly suggested the MPT was formed by the inner membrane Adenine Nucleotide ... "The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore". Nature. 427 (6973): 461-465. doi ... "The nature of the calcium ion efflux induced in rat liver mitochondria by the oxidation of endogenous nicotinamide nucleotides ... "Regulation of the Inner Membrane Mitochondrial Permeability Transition by the Outer Membrane Translocator Protein (Peripheral ...
https://en.wikipedia.org/wiki/Mitochondrial_permeability_transition_pore
Kallikrein 3/PSA Antibody (KLK3/801) (NBP2-44886): Novus BiologicalsKallikrein 3/PSA Antibody (KLK3/801) (NBP2-44886): Novus Biologicals
Adenine Nucleotide. Translocator 2 Antibo ... NBP2-92630. Species: Hu, Mu, Rt. Applications: ICC/IF, IHC, IHC-P, WB ... Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C. Antibody is stable for 24 months. Non- ...
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Progressive external ophthalmoplegia: MedlinePlus GeneticsProgressive external ophthalmoplegia: MedlinePlus Genetics
Role of adenine nucleotide translocator 1 in mtDNA maintenance. Science. 2000 Aug 4;289(5480):782-5. doi: 10.1126/science. ... The adenine nucleotide translocase type 1 (ANT1): a new factor in mitochondrial disease. IUBMB Life. 2005 Sep;57(9):607-14. doi ... Less commonly, mutations that change single nucleotides in genes found in mtDNA, such as the MT-TL1 gene, cause progressive ... The size of the deleted region can range from 2,000 to 10,000 DNA building blocks (nucleotides). ...
https://medlineplus.gov/genetics/condition/progressive-external-ophthalmoplegia/
Science Clips - Volume 9, Issue 22, June 6, 2017Science Clips - Volume 9, Issue 22, June 6, 2017
20 and adenine nucleotide translocator (ANT) 1/2/3/4 that regulate mitochondrial permeability. The results suggest that an ... The isolates were 20 and 26 nucleotide divergent from prototype Sabin strain (with 18 identical mutations) consistent with ... and Candida lusitaniae Targeting rDNA region nucleotide sequences, primers specific for C. auris only or C. auris and related ... All used SRS and 378 (98.4%) only identified all five microfoci if they were 2-3 km diameter or high-intensity (6x or 10x); 374 ...
https://www.cdc.gov/library/sciclips/issues/v9issue22.html
尋找研究成果 - 臺北醫學大學
Antimicrobial peptide TP4 targets mitochondrial adenine nucleotide translocator 2. Su, B. C., Liu, Y. C., Ting, C. H., Lyu, P. ... Yeh, C. B., Hsieh, M. J., Hsieh, Y. H., Chien, M. H., Chiou, H. L. & Yang, S. F., 2月 7 2012, 於: PLoS One. 7, 2, e31055.. 研究成果: ... Wang, C. W., Hsu, W. H. & Tai, C. J., 2017, 於: Oncotarget. 8, 2, p. 3049-3058 10 p.. 研究成果: 雜誌貢獻 › 文章 › 同行評審 ... Lee, H. & Lin, J. Y., 1988, 於: Mutation Research - Genetic Toxicology. 204, 2, p. 229-234 6 p.. 研究成果: 雜誌貢
https://tmu.pure.elsevier.com/zh/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&publicationYear=2017&publicationYear=2018&format=&nofollow=true&ordering=title&descending=false&page=62
Viruses as Modulators of Mitochondrial FunctionsViruses as Modulators of Mitochondrial Functions
H. L. A. Vieira, A. S. Belzacq, D. Haouzi et al., "The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite ... "Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat ... and the adenine nucleotide translocase (ANT) [51], the primary role of mitochondrial Ca2+ is in the stimulation of ox-phos [52- ... inner membrane adenine nucleotide translocase (ANT) [127], and cyclophilin D (CyP-D) in matrix are the structural elements of ...
https://www.hindawi.com/journals/av/2013/738794/
Antiandrogen-induced cell death in LNCaP human prostate cancer cells | Cell Death & DifferentiationAntiandrogen-induced cell death in LNCaP human prostate cancer cells | Cell Death & Differentiation
Overexpression of Bcl-2 in LNCaP cells attenuates the induction of cell death by TNF-α but not Casodex, suggesting that ... these data support the hypothesis that Casodex induces cell death by a pathway that is independent of changes in ΔΨm and Bcl-2 ... been shown to increase its cytotoxicity and has been implicated in facilitating the assemble of adenine nucleotide translocator ... Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator ...
https://www.nature.com/articles/4401228?error=cookies_not_supported&code=c5cc6052-6155-4537-9885-21591a64cbf4
NIOSHTIC-2 Search Results - Full View
... membrane and in normal operation of other mitochondrial multicomponent machines such as adenine nucleotide translocator, as ... Bid, a BH3-only proapoptotic member of the Bcl-2 family, and the carboxyl terminus of its cleavage product, tBid, are essential ... 2-5) In normal cells, CL is predominantly localized in the inner membrane and contact sites. It plays a very important role in ... 2) a scavenger of superoxide anion radicals.(13) Recently, we have reported that CL avidly binds cyt c, partially unfolds the ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=genetic&f1=TI&Startyear=&t1=1&s2=genetic&terms=3&Adv=1&ct=&B1=Search&f2=KW&Limit=500&Sort=DP+DESC&D1=10&EndYear=&PageNo=39&RecNo=389&View=f&
MH DELETED MN ADDED MNMH DELETED MN ADDED MN
Adenine Nucleotide Translocator 1 D12.776.157.530.937.594.100 D12.776.543.585.937.688.100 Adenine Nucleotide Translocator 2 ... Adenine Nucleotide Translocator 3 D12.776.157.530.937.594.300 D12.776.543.585.937.688.300 Adenine Nucleotides D3.438.759.646. ... Cyclic Nucleotide 3-Phosphodiesterase D12.776.641.580.124 D12.776.631.580.124 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- ... Purine Nucleotides D3.438.759.646 D3.633.100.759.646 Purines D3.438.759 D3.633.100.759 Purinones D3.438.759.758 D3.633.100.759. ...
https://decs.bvs.br/E/mnchg2017.txt
Cancer Research - Fabgennix InternationalCancer Research - Fabgennix International
The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target...
... adenine nucleotide translocator (ANT), and cyclophilin D (CyPD). Nitration of CyPD and ANT in LGN mitochondria occurs by 2 d ... adenine nucleotide translocator (ANT), and cyclophilin D (CyPD). Nitration of CyPD and ANT in LGN mitochondria occurs by 2 d ... adenine nucleotide translocator (ANT), and cyclophilin D (CyPD). Nitration of CyPD and ANT in LGN mitochondria occurs by 2 d ... adenine nucleotide translocator (ANT), and cyclophilin D (CyPD). Nitration of CyPD and ANT in LGN mitochondria occurs by 2 d ...
https://jhu.pure.elsevier.com/en/publications/the-mitochondrial-permeability-transition-pore-regulates-nitric-o-3
ADAM8 Antibody [Unconjugated] (AF1031): Novus BiologicalsADAM8 Antibody [Unconjugated] (AF1031): Novus Biologicals
Adenine Nucleotide. Translocator 2 Antibo ... NBP2-92630. Species: Hu, Mu, Rt. Applications: ICC/IF, IHC, IHC-P, WB ... 1 month, 2 to 8 °C under sterile conditions after reconstitution.. *6 months, -20 to -70 °C under sterile conditions after ... 2). ADAM8 can cleave a variety of substrates and has been shown as a sheddase for the low affinity IgE receptor CD23 and the ...
https://www.novusbio.com/products/adam8-antibody_af1031
Identification of an Epitope from Adenine Nucleotide Translocator 1 that Induces Inflammation in Heart in A/J MiceIdentification of an Epitope from Adenine Nucleotide Translocator 1 that Induces Inflammation in Heart in A/J Mice
Role of an adenine-nucleotide translocator in regulation of mitochondrial pyruvate oxidation in the heart. Bulletin of ... Inhibition of the adenine nucleotide translocator by matrix-localized palmityl-CoA in rat heart mitochondria. Biochimica et ... Participation of the adenine nucleotide translocator in the regulation of pyruvate oxidation in heart mitochondria. Biulleten& ... The role of adenine nucleotide translocator in the regulation of oxidative phosphorylation in heart mitochondria. Biokhimiia 53 ...
https://eurekamag.com/research/058/038/058038534.php
IJMS | Free Full-Text | Genes and Pathways Involved in Adult Onset Disorders Featuring Muscle Mitochondrial DNA InstabilityIJMS | Free Full-Text | Genes and Pathways Involved in Adult Onset Disorders Featuring Muscle Mitochondrial DNA Instability
Adenine nucleotide translocator. AD. Adult. dels. muscle. PEO. TYMP. 22q13. Thymidine phosphorylase. AR. Late childhood ... Role of adenine nucleotide translocator 1 in mtDNA maintenaince. Science 2000, 289, 782-785. [Google Scholar] [CrossRef] [ ... Adenine nucleotide translocator 1 deficiency associated with Sengers syndrome. Ann. Neurol. 2002, 52, 95-99. [Google Scholar] [ ... Dörner, A.; Schultheiss, H.P. Adenine nucleotide translocase in the focus of cardiovascular diseases. Trends Cardiovasc. Med. ...
https://www.mdpi.com/1422-0067/16/8/18054/htm
DeCSDeCS
Adenine Nucleotide Translocator 2 - Preferred Concept UI. M0000350. Scope note. A subtype of mitochondrial ADP, ATP translocase ... Adenine Nucleotide Translocator 2 Entry term(s). ANT 2 Transport Protein ANT-2 Transport Protein ANT2 Transport Protein Adenine ... Adenine Nucleotide Translocator, Fibroblast Isoform. SLC25A5 Protein. Solute Carrier Family 25 Member 5. Solute Carrier Family ... Solute Carrier-Family 25 (Mitochondrial Carrier - Adenine Nucleotide Translocator), Member 5 Transport Protein, ANT-2 Transport ...
https://decs.bvsalud.org/en/ths/resource/?id=37401
Reactome | SLC25A5 [mitochondrial inner membrane]Reactome | SLC25A5 [mitochondrial inner membrane]
... adenine nucleotide translocator 2, ADP/ATP translocase 2, Adenine nucleotide translocator 2, ANT 2 ... ADP/ATP translocase 2 monomer, ADP,ATP carrier protein, fibroblast isoform, ...
https://reactome.org/content/detail/R-HSA-49743
KEGG ORTHOLOGY: K05863
K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. 04022 cGMP-PKG ... K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. 09160 Human ... K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. 05020 Prion ... K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. 09180 Brite ...
https://www.genome.jp/dbget-bin/www_bget?ko:K05863
Pesquisa | Portal Regional da BVSPesquisa | Portal Regional da BVS
Bufarenogin induced intrinsic apoptosis through the cooperation of Bax and adenine-nucleotide translocator and inhibited the ... we showed that adenine-nucleotide translocator interacted with Bax. ... assays based on single nucleotide polymorphisms (SNPs) at these four E loci, and genotyped E1-E4 genes across 308 Chinese ... Changes in three-dimensional arterial spin labeling perfusion imaging of the hippocampus in depressive Itpr2-/- mice]. ...
https://pesquisa.bvsalud.org/portal/?lang=pt&q=au:Sun,+Xuegang
Association of novel POLG mutations and multiple mitochondrial DNA deletions with variable clinical phenotypes in a Spanish...Association of novel POLG mutations and multiple mitochondrial DNA deletions with variable clinical phenotypes in a Spanish...
Adenine Nucleotide Translocator 1 * DNA, Mitochondrial * Mitochondrial Proteins * DNA Primase * DNA Polymerase gamma ... Thirteen patients had PEO; 2 had PEO alone, 4 had PEO and myopathy, and 5 had PEO and multisystem involvement. Four patients ... 2 were compound heterozygotes, 1 was homozygous, and another showed a mutation in a single allele. The remaining patient also ...
https://pubmed.ncbi.nlm.nih.gov/16401742/
研究成果を検索 - Keio University
A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed ... Ko, M. S. H., Naomi, T., Norifumi, S. & Toshiya, T., 1989 12月 14, In: Gene. 84, 2, p. 383-389 7 p.. 研究成果: Article › 査読 ... Misawa, H., Ueda, H. & Satoh, M., 1990 5月 4, In: Neuroscience Letters. 112, 2-3, p. 324-327 4 p.. 研究成果: Article › 査読 ... Yamanaka, N., Kikuchi, S. & Suzuki, M., 1989 10月 26, In: Electronics Letters. 25, 22, p. 1470-1471 2 p.. 研究成果: Article › 査読 ...
https://keio.pure.elsevier.com/ja/publications/?indexableKeyword=%2Fdk%2Fatira%2Fpure%2Fsustainabledevelopmentgoals%2Fpeace_justice_and_strong_institutions&format=&page=1611
AZD5438 | Ligand Activity Charts | IUPHAR/BPS Guide to PHARMACOLOGYAZD5438 | Ligand Activity Charts | IUPHAR/BPS Guide to PHARMACOLOGY
Mitochondrial adenine nucleotide translocator 2/ADP/ATP translocase 2 in Human [ChEMBL: CHEMBL3709670] [GtoPdb: 1063] [ ... Adenine phosphoribosyltransferase in Human [ChEMBL: CHEMBL4105819] [UniProtKB: P07741] There should be some charts here, you ... Adenylate kinase 2 in Human [ChEMBL: CHEMBL4938] [UniProtKB: P54819] There should be some charts here, you may need to enable ... casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Human [ChEMBL: CHEMBL4070] [GtoPdb: 1550] [ ...
https://www.guidetomalariapharmacology.org/GRAC/LigandActivityRangeVisForward?ligandId=8473
IMP: Integrative Multi-species Prediction
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13. 0.012. ...
http://imp.princeton.edu/predictions/process/mouse-context-global/3621/?gene=61978
TomoSeq data searchTomoSeq data search
Adenine Nucleotide Translocator [Source:RefSeq peptide;Acc:NP_001022799]. 3.. T04C12.6. act-1. 761.00. 4040.43. Actin-1 [Source ... prdx-2. 335.00. 1778.64. PeRoxireDoXin [Source:RefSeq peptide;Acc:NP_872052]. 89.. F26D10.3. hsp-1. 335.00. 1778.64. Heat shock ... Y75B12B.2. cyn-7. 412.00. 2187.46. Peptidyl-prolyl cis-trans isomerase 7 [Source:UniProtKB/Swiss-Prot;Acc:P52015]. ... far-2. 693.00. 3679.39. Fatty-acid and retinol-binding protein 2 [Source:UniProtKB/Swiss-Prot;Acc:P34383]. ...
http://celegans.tomoseq.genomes.nl/section?db=sections&lib=male1&s=s16
Innate Immune Evasion Strategies of Influenza VirusesInnate Immune Evasion Strategies of Influenza Viruses
PB1-F2 interacts with the mitochondrial apoptotic mediators adenine nucleotide translocator 3 and voltage-dependent anion ... 2. 87. Polymerase component. PB1-PA interaction. Polymerase function (e.g., T-705*). [204] [205] ... 2 (+1 ORF). 8. Induction of apoptosis in immune cells. Sites of interaction with cellular proteins?. Oligomerization?. ... Box 2. Antigenic drift versus antigenic shift. *. Antigenic drift is the process whereby mutations accumulate in viral surface ...
https://www.medscape.com/viewarticle/715267_4
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
Adenine Nucleotide Translocator 1 D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 ... Adenine Nucleotide Translocator 3 D12.776.543.585.475.500.300 Adenomatous Polyposis Coli Protein D5.500.117.249 D12.776.476.81. ... A1.923.47.365 H-2 Antigens D23.50.301.500.400.350 D23.50.301.500.100.350 D23.50.705.552.400.350 D23.50.301.500.400.199 D23.50. ... D12.776.575.750.750 Voltage-Dependent Anion Channel 2 D12.776.543.585.475.875 D12.776.575.750.875 Walking G11.427.590.530. ...
https://decs2017.bvsalud.org/E/mnchg2012.txt
MH DELETED MN ADDED MN
Adenine Nucleotide Translocator 1 D12.776.157.530.937.594.100 D12.776.543.585.937.688.100 Adenine Nucleotide Translocator 2 ... Adenine Nucleotide Translocator 3 D12.776.157.530.937.594.300 D12.776.543.585.937.688.300 Adenine Nucleotides D3.438.759.646. ... Cyclic Nucleotide 3-Phosphodiesterase D12.776.641.580.124 D12.776.631.580.124 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- ... Purine Nucleotides D3.438.759.646 D3.633.100.759.646 Purines D3.438.759 D3.633.100.759 Purinones D3.438.759.758 D3.633.100.759. ...
https://decs2018.bvsalud.org/E/mnchg2017.txt
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
Adenine Nucleotide Translocator 1 D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 ... Adenine Nucleotide Translocator 3 D12.776.543.585.475.500.300 Adenomatous Polyposis Coli Protein D5.500.117.249 D12.776.476.81. ... A1.923.47.365 H-2 Antigens D23.50.301.500.400.350 D23.50.301.500.100.350 D23.50.705.552.400.350 D23.50.301.500.400.199 D23.50. ... D12.776.575.750.750 Voltage-Dependent Anion Channel 2 D12.776.543.585.475.875 D12.776.575.750.875 Walking G11.427.590.530. ...
https://decs2015.bvsalud.org/E/mnchg2012.txt
MH DELETED MN ADDED MN
Adenine Nucleotide Translocator 1 D12.776.157.530.937.594.100 D12.776.543.585.937.688.100 Adenine Nucleotide Translocator 2 ... Adenine Nucleotide Translocator 3 D12.776.157.530.937.594.300 D12.776.543.585.937.688.300 Adenine Nucleotides D3.438.759.646. ... Cyclic Nucleotide 3-Phosphodiesterase D12.776.641.580.124 D12.776.631.580.124 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- ... Purine Nucleotides D3.438.759.646 D3.633.100.759.646 Purines D3.438.759 D3.633.100.759 Purinones D3.438.759.758 D3.633.100.759. ...
https://decs2019.bvsalud.org/P/mnchg2017.txt
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
Adenine Nucleotide Translocator 1 D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 ... Adenine Nucleotide Translocator 3 D12.776.543.585.475.500.300 Adenomatous Polyposis Coli Protein D5.500.117.249 D12.776.476.81. ... A1.923.47.365 H-2 Antigens D23.50.301.500.400.350 D23.50.301.500.100.350 D23.50.705.552.400.350 D23.50.301.500.400.199 D23.50. ... D12.776.575.750.750 Voltage-Dependent Anion Channel 2 D12.776.543.585.475.875 D12.776.575.750.875 Walking G11.427.590.530. ...
https://decs2013.bvsalud.org/P/mnchg2012.txt
ANT1Mitochondrial ProteinsVoltage-dependePhosphoribosyltransferase4q35GenesKinasePhosphateMemberMutationsMitochondriaProto-oncogeneAntibodyArrestinApoptosisInducibleProapoptoticAntiapoptoticSourceCompartmentHumanExpressionCellsPhase
ANT12
  • In support of this notion, intracellular cardiac antigens, like cardiac myosin heavy chain-α, cardiac troponin-I, and adenine nucleotide translocator 1 (ANT1), have been identified as autoantigens in cardiac autoimmunity. (eurekamag.com)
  • Adenine nucleotide translocator 1 (ANT1), the only 4q35 gene involved in mitochondrial function, is strongly expressed in FSHD skeletal muscle biopsies. (mysciencework.com)
Mitochondrial Proteins1
  • 2013). Additionally, decreases in cellular PA may also destabilize the assembly of the adenine nucleotide translocators (ANTs), a subset of highly abundant mitochondrial proteins essential for ADP/ATP translocation across the mitochondrial inner membrane (Mayr et al. (preventiongenetics.com)
Voltage-depende2
  • Putative components of the mPTP are expressed in mouse LGN, including the voltage-dependent anion channel (VDAC), adenine nucleotide translocator (ANT), and cyclophilin D (CyPD). (elsevier.com)
  • The 18 kDa translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is a hetero-oligomeric complex comprising the voltage-dependent anion channel as well as an adenine nucleotide carrier found in both the periphery and the brain [ 1 - 4 ]. (biomedcentral.com)
Phosphoribosyltransferase1
4q352
  • About 2% of FSHD patients are not linked to the locus at 4q35. (medscape.com)
  • The probe p13E-11 identifies 2 polymorphic loci at 4q35 and 10q26. (medscape.com)
Genes1
  • Less commonly, mutations that change single nucleotides in genes found in mtDNA, such as the MT-TL1 gene, cause progressive external ophthalmoplegia. (medlineplus.gov)
Kinase1
Phosphate1
  • It plays a very important role in the assembly and maintenance of functionally active respiratory complexes (I, III and IV and F0/F1-ATPase) in the mitochondrial membrane and in normal operation of other mitochondrial multicomponent machines such as adenine nucleotide translocator, as well as tricarboxylate, pyruvate and phosphate carriers. (cdc.gov)
Member2
  • Bid, a BH3-only proapoptotic member of the Bcl-2 family, and the carboxyl terminus of its cleavage product, tBid, are essential regulators of early mitochondrial apoptotic events and release of pro-apoptotic factors into the cytosol. (cdc.gov)
  • ADAM8, also known as cell surface antigen MS2 or CD156a, is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain (1, 2). (novusbio.com)
Mutations1
  • Five patients with PEO had mutations: 2 were compound heterozygotes, 1 was homozygous, and another showed a mutation in a single allele. (nih.gov)
Mitochondria5
  • Mitochondria contain a single 16 kb circular DNA genome, which codes for 13 proteins (mostly subunits of respiratory chains I, II, IV, and V), 22 mitochondrial tRNAs and 2 rRNAs [ 25 , 26 ]. (hindawi.com)
  • Overexpression of Bcl-2 in LNCaP cells attenuates the induction of cell death by TNF- α but not Casodex, suggesting that mitochondria depolarization is not required for the induction of cell death by Casodex. (nature.com)
  • 4,12) Cyt c is an important contributor to redox reactions in the intermembrane space of mitochondria where it functions as (1) an electron shuttle between respiratory complexes III and IV and (2) a scavenger of superoxide anion radicals. (cdc.gov)
  • Nitration of CyPD and ANT in LGN mitochondria occurs by 2 d after cortical injury. (elsevier.com)
  • 2) The cancer cell's mitochondria have undergone "metabolic reprogramming," thereby providing a key which can be exploited to devise a more selective cancer treatment. (greenmedinfo.com)
Proto-oncogene1
Antibody1
Arrestin1
Apoptosis2
  • Prevention of lymphocyte apoptosis, same process by which these cell populations are regulat- through either genetic modification of the host or treatment ed during normal health ( 1 , 2 ). (cdc.gov)
  • Mice without CyPDare rescued from neuron apoptosis as are mice treated with the mPTP inhibitors TRO-19622 (cholest-4-en-3-one oxime) and TAT-Bcl-X L -BH4. (elsevier.com)
Inducible1
Proapoptotic2
  • These include members of the Bcl-2 protein family, course, and extent of programmed cell death will aid man- which have both proapoptotic and antiapoptotic activity agement of patients with severe infections. (cdc.gov)
  • Key regulators of the mitochondrial pathway include both antiapoptotic and proapoptotic members of the Bcl-2 family of proteins. (nature.com)
Antiapoptotic1
  • Bcl-2 is antiapoptotic), and other inhibitors (Figure 1). (cdc.gov)
Source4
  • Starch is a repository of carbon which is later used during the dark phase as the primary carbon source for biomass formation [ 2 ] and fuelling of sucrose biosynthesis and its transport. (biomedcentral.com)
  • CDC42 small effector 2 [Source:HGNC Sy. (gsea-msigdb.org)
  • dihydropyrimidinase like 2 [Source:HGN. (gsea-msigdb.org)
  • high mobility group box 2 [Source:HGNC. (gsea-msigdb.org)
Compartment1
  • In this model, the phloem was considered as a non-growing transport compartment, the mesophyll compartment was considered as both autotrophic (growing on CO 2 under light) and heterotrophic (growing on starch in darkness), and the root was always considered as heterotrophic tissue dependent on sucrose supply from the mesophyll compartment. (biomedcentral.com)
Human1
  • We studied the distribution and expression of translocator protein in the human brain using 11 C-[R]-PK-11195 positron emission tomography (PK11195 PET) and evaluated age-related changes. (biomedcentral.com)
Expression2
  • The brain shows low PK11195 uptake, which is lower in the cortex and cerebellum compared with subcortical structures, suggesting a low level of translocator protein expression. (biomedcentral.com)
  • This increase in uptake suggests an age-related increase in translocator protein expression or the number of cells expressing these receptors or both. (biomedcentral.com)
Cells1
  • 2-5) In normal cells, CL is predominantly localized in the inner membrane and contact sites. (cdc.gov)
Phase1
  • Taken together, these data support the hypothesis that Casodex induces cell death by a pathway that is independent of changes in ΔΨ m and Bcl-2 actions and results in an extended lag phase of cell survival that may promote the induction of an invasive phenotype after treatment. (nature.com)
Progressive external ophthalmoplegia: MedlinePlus Genetics
Progressive external ophthalmoplegia: MedlinePlus Genetics (medlineplus.gov)
Immune Cell Apoptosis Prevention as Potential Therapy for Severe Infections - Volume 13, Number 2-February 2007 - Emerging...
Immune Cell Apoptosis Prevention as Potential Therapy for Severe Infections - Volume 13, Number 2-February 2007 - Emerging... (wwwnc.cdc.gov)
Viruses as Modulators of Mitochondrial Functions
Viruses as Modulators of Mitochondrial Functions (hindawi.com)
SLC25A4 gene: MedlinePlus Genetics
SLC25A4 gene: MedlinePlus Genetics (medlineplus.gov)
研究成果を検索 - Keio University
研究成果を検索 - Keio University (keio.pure.elsevier.com)
Facioscapulohumeral Dystrophy: Background, Pathophysiology, Epidemiology
Facioscapulohumeral Dystrophy: Background, Pathophysiology, Epidemiology (medscape.com)
Cancer as a Curable Metabolic Disease | GreenMedInfo | Blog Entry
Cancer as a Curable Metabolic Disease | GreenMedInfo | Blog Entry (greenmedinfo.com)
MitoPedia - Bioblast
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Metabolic model of central carbon and energy metabolisms of growing Arabidopsis thaliana in relation to sucrose translocation |...
Metabolic model of central carbon and energy metabolisms of growing Arabidopsis thaliana in relation to sucrose translocation |... (bmcplantbiol.biomedcentral.com)
Evaluation of age-related changes in translocator protein (TSPO) in human brain using 11C-[R]-PK11195 PET | Journal of...
Evaluation of age-related changes in translocator protein (TSPO) in human brain using 11C-[R]-PK11195 PET | Journal of... (jneuroinflammation.biomedcentral.com)
SustainPineDB
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John Lemasters | Profiles RNS
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Search Redox biology as journal on MyScienceWork's publications...
Search Redox biology as journal on MyScienceWork's publications... (mysciencework.com)
Giant cell arteritis: immune and vascular aging as disease risk factors | Arthritis Research & Therapy | Full Text
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Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of...
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Slc25a13 ELISA Kits
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60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH in: Journal of Molecular Endocrinology Volume 56 Issue 4 (2016)
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Human RAB5C(RAB5C, Member RAS Oncogene Family) ELISA Kit - Hiv Pharmacogenomics
Human RAB5C(RAB5C, Member RAS Oncogene Family) ELISA Kit - Hiv Pharmacogenomics (hiv-pharmacogenomics.org)
Dna ancestry - Scalegenomics
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