Adenine Nucleotide Translocator 1
Mitochondrial ADP, ATP Translocases
A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization.
Adenine Nucleotide Translocator 2
Atractyloside
Bongkrekic Acid
Adenine Nucleotide Translocator 3
Oxidative Phosphorylation
Mitochondria
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Mitochondria, Liver
Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)
Intracellular Membranes
Adenosine Diphosphate
Adenosine Triphosphate
Voltage-Dependent Anion Channels
Mitochondrial Membrane Transport Proteins
Mitochondrial Swelling
Oxygen Consumption
Cyclophilins
Membrane Potential, Mitochondrial
Uncoupling Agents
Cell Respiration
Permeability
Aryl Hydrocarbon Receptor Nuclear Translocator
Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with DIOXIN RECEPTOR. The complex binds xenobiotic regulatory elements and activates transcription of a variety of genes including UDP GLUCURONOSYLTRANSFERASE. AhR nuclear translocator is also a subunit of HYPOXIA-INDUCIBLE FACTOR 1.
Proto-Oncogene Proteins c-bcl-2
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
Mitochondrial Proteins
Nucleotides
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Membrane Potentials
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
DNA, Mitochondrial
Adenosine Monophosphate
Myocardium
Receptors, GABA
Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.
Receptors, Aryl Hydrocarbon
Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.
Energy Metabolism
Purine Nucleotides
Amino Acid Sequence
Adenosine
Base Sequence
Induction of an unregulated channel by mutations in adenine nucleotide translocase suggests an explanation for human ophthalmoplegia. (1/69)
Adenine nucleotide translocase (Ant) is primarily involved in ATP/ADP exchange across the mitochondrial inner membrane. Recently, the A114P missense mutation in the human Ant1 protein was found to be associated with autosomal dominant progressive external ophthalmoplegia (adPEO). Ant1(A114P) was proposed to cause an imbalance of the mitochondrial deoxynucleotide pool that subsequently affects the accuracy of mtDNA replication, thereby leading to accumulation of mutant mtDNA. In the present study, it has been shown that the A128P mutation of the Saccharomyces cerevisiae Aac2 protein, equivalent to A114P in human Ant1p, does not always affect respiratory growth. However, expression of aac2(A128P) results in depolarization, structural swelling and disintegration of mitochondria, and ultimately an arrest of cell growth in a dominant-negative manner. The aac2(A128P) mutation likely induces an unregulated channel allowing free passage of solutes across the inner membrane. These data raise the possibility that the formation of an unregulated channel, rather than a defect in ATP/ADP exchange, is a direct pathogenic factor in human adPEO. The accumulation of mtDNA mutations might be a consequence of mitochondrial dysfunction. (+info)Skeletal muscle mitochondrial free-fatty-acid content and membrane potential sensitivity in different thyroid states: involvement of uncoupling protein-3 and adenine nucleotide translocase. (2/69)
The effect of triiodothyronine (T3) on mitochondrial efficiency could be related to an increase in the concentrations of some proteins, such as uncoupling proteins (UCPs). Free fatty acids (FFA) seem to be a cofactor essential for the uncoupling activity of UCP3. In this paper, we report that the hypothyroidism-hyperthyroidism transition is accompanied by increases: (i) in the endogenous levels of mitochondrial FFA and (ii) in the sensitivity to FFA shown by the mitochondrial respiration rate and membrane potential, which correlated with the level of UCP3 protein. The level of the mRNA for adenine-nucleotide translocase-1 (ANT) was not affected by the thyroid state, while the ANT contribution to FFA-induced changes in mitochondrial uncoupling was low in the hypothyroid and euthyroid states but became more relevant in the hyperthyroid state at the highest concentration of FFA. (+info)Hypothermia preserves myocardial function and mitochondrial protein gene expression during hypoxia. (3/69)
Hypothermia before and/or during no-flow ischemia promotes cardiac functional recovery and maintains mRNA expression for stress proteins and mitochondrial membrane proteins (MMP) during reperfusion. Adaptation and protection may occur through cold-induced change in anaerobic metabolism. Accordingly, the principal objective of this study was to test the hypothesis that hypothermia preserves myocardial function during hypoxia and reoxygenation. Hypoxic conditions in these experiments were created by reducing O2 concentration in perfusate, thereby maintaining or elevating coronary flow (CF). Isolated Langendorff-perfused rabbit hearts were subjected to perfusate (Po2 = 38 mmHg) with glucose (11.5 mM) and perfusion pressure (90 mmHg). The control (C) group was at 37 degrees C for 30 min before and 45 min during hypoxia, whereas the hypothermia (H) group was at 29.5 degrees C for 30 min before and 45 min during hypoxia. Reoxygenation occurred at 37 degrees C for 45 min for both groups. CF increased during hypoxia. The H group markedly improved functional recovery during reoxygenation, including left ventricular developed pressure (DP), the product of DP and heart rate, dP/dtmax, and O2 consumption (MVo2) (P < 0.05 vs. control). MVo2 decreased during hypothermia. Lactate and CO2 gradients across the coronary bed were the same in C and H groups during hypoxia, implying similar anaerobic metabolic rates. Hypothermia preserved MMP betaF1-ATPase mRNA levels but did not alter adenine nucleotide translocator-1 or heat shock protein-70 mRNA levels. In conclusion, hypothermia preserves cardiac function after hypoxia in the hypoxic high-CF model. Thus hypothermic protection does not occur exclusively through cold-induced alterations in anaerobic metabolism. (+info)Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling. (4/69)
Identification of factors regulating cardiomyocyte survival and growth is important to understand the pathogenesis of congenital heart diseases. Little is known about the molecular mechanism of cardiac functions triggered by serotonin. The link between signaling circuitry of external stimuli and the mitochondrial apoptotic machinery is of wide interest in cardiac diseases. Using cultured cardiomyocytes and 5-hydroxytryptamine (5-HT)2B-receptor knockout mice as an animal model of dilated cardiomyopathy, for the first time we show that serotonin via the Gq-coupled 5-HT2B-receptor protect cardiomyocytes against serum deprivation-induced apoptosis as manifested by DNA fragmentation, nuclear chromatin condensation, and TUNEL labeling. Serotonin prevents cytochrome c release and caspase-9 and -3 activation after serum deprivation via cross-talks between phosphatidylinositol-3 kinase/Akt and extracellular signal-regulated kinase (ERK) 1/2 signaling pathways. Serotonin binding to 5-HT2B-receptor activates ERK kinases to inhibit Bax expression induced by serum deprivation. Serotonin via phosphatidylinositol-3 kinase/Akt can activate NF-kappaB that is required for the regulation of the mitochondrial adenine nucleotide translocator (ANT-1). Parallel to these observations, ultrastructural analysis in the 5-HT2B-receptor knockout mice heart revealed pronounced mitochondrial defects in addition to altered mitochondrial enzyme activities (cytochrome oxidase and succinate dehydrogenase) and ANT-1 and Bax expressions. These findings identify 5-HT as a novel survival factor targeting mitochondria in cardiomyocytes. (+info)A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells. (5/69)
Mitochondria are the powerhouse of the cell and their disruption leads to cell death. We have used a peptide trivalent arsenical, 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO), to inactivate the adenine nucleotide translocator (ANT) that exchanges matrix ATP for cytosolic ADP across the inner mitochondrial membrane and is the key component of the mitochondrial permeability transition pore (MPTP). GSAO triggered Ca(2+)-dependent MPTP opening by crosslinking Cys(160) and Cys(257) of ANT. GSAO treatment caused a concentration-dependent increase in superoxide levels, ATP depletion, mitochondrial depolarization, and apoptosis in proliferating, but not growth-quiescent, endothelial cells. Endothelial cell proliferation drives new blood vessel formation, or angiogenesis. GSAO inhibited angiogenesis in the chick chorioallantoic membrane and in solid tumors in mice. Consequently, GSAO inhibited tumor growth in mice with no apparent toxicity at efficacious doses. (+info)Increased adenine nucleotide translocator 1 in reactive astrocytes facilitates glutamate transport. (6/69)
A hallmark of central nervous system (CNS) pathology is reactive astrocyte production of the chronic glial scar that is inhibitory to neuronal regeneration. The reactive astrocyte response is complex; these cells also produce neurotrophic factors and are responsible for removal of extracellular glutamate, the excitatory neurotransmitter that rises to neurotoxic levels in injury and disease. To identify genes expressed by reactive astrocytes, we employed an in vivo model of the glial scar and differential display PCR and found an increase in the level of Ant1, a mitochondrial ATP/ADP exchanger that facilitates the flux of ATP out of the mitochondria. Ant1 expression in reactive astrocytes is regulated by transforming growth factor-beta1, a pluripotent CNS injury-induced cytokine. The significance of increased Ant1 is evident from the observation that glutamate uptake is significantly decreased in astrocytes from Ant1 null mutant mice while a specific Ant inhibitor reduces glutamate uptake in wild-type astrocytes. Thus, the astrocytic response to CNS injury includes an apparent increase in energy mobilization capacity by Ant1 that contributes to neuroprotective, energy-dependent glutamate uptake. (+info)Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity. (7/69)
Mitochondrial permeability transition (MPT) has been proposed to play a key role in cell death. Downstream MPT events include the release of apoptogenic factors that sets in motion the mitochondrial apoptosome leading to caspase activation. The current work examined the regulation of MPT by membrane fluidity modulated upon cholesterol enrichment. Mitochondria enriched in cholesterol displayed increased microviscosity resulting in impaired MPT induced by atractyloside, a c-conformation stabilizing ligand of the adenine nucleotide translocator (ANT). This effect was dependent on the dose of cholesterol loaded and reversed upon the fluidization of mitochondria by the fatty acid derivative A2C. Mitoplasts derived from cholesterol-enriched mitochondria responded to atractyloside in a similar fashion as intact mitochondria, indicating that a significant amount of cholesterol is still found in the inner membrane. The effects of cholesterol on MPT induced by atractyloside were mirrored by the release of intermembrane proteins, cytochrome c, Smac/Diablo, and apoptosis inducing factor. However, cholesterol loading did not affect the uptake rate of adenine nucleotide hence dissociating the function of ANT as a MPT-mediated protein from its adenine nucleotide exchange function. Thus, these findings indicate that the ability of atractyloside to induce MPT via ANT requires an appropriate membrane fluidity range. (+info)Protein components of mitochondrial DNA nucleoids in higher eukaryotes. (8/69)
Mitochondrial DNA (mtDNA) is not packaged in nucleosomal particles, but has been reported to associate with the mitochondrial inner membrane. Gentle lysis of Xenopus oocyte mitochondria with nonionic detergent liberates a nucleoprotein complex containing mtDNA associated with a previously characterized DNA binding partner, mitochondrial transcription factor A (mtTFA), as well as a series of inner membrane proteins identified by sequencing. More extensive detergent treatment stripped most of these proteins from the DNA, leaving a limited number of proteins in a nucleoid core. Sequencing of the major proteins retained in association with mtDNA revealed the expected mtDNA binding proteins, mtTFA and mitochondrial single-stranded DNA binding protein (mtSSB), as well as four proteins not previously reported to associate with mtDNA. These include adenine nucleotide translocator 1, the lipoyl-containing E2 subunits of pyruvate dehydrogenase and branched chain alpha-ketoacid dehydrogenase and prohibitin 2. The association of several of these proteins with mtTFA-containing mtDNA nucleoids was confirmed by immunoprecipitation. (+info)
Adenine nucleotide translocator synonyms, Adenine nucleotide translocator antonyms - FreeThesaurus.com
Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2...
Slc25a13 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 ...
Slc25a4 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 (cDNA...
Selleck Chemicals Blog-Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells
Anti-Adenine Nucleotide Translocator 2 antibody (ab118125)
Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) |...
Mitochondriales TRNG-Gen
anti-SLC25A31 antibody | GeneTex
Free to contact best and highest rated dating online website for women in vancouver
Gentaur Molecular :Prospecbio \ Mouse Anti HA-tag peptide clone PHASHG HA-tag Peptide \ ant-225
Gentaur Molecular :Prospecbio \ Polyclonal Rabbit Anti HA tag peptide \ ANT-234
Cisco ANT-4G-DP-IN-TNC now 45% off Multiband Swivel Mount Dipole Indoor 4G Antenna
Biology Resources | Grinnell College
Adenine nucleotide translocator 1 | definition of adenine nucleotide translocator 1 by Medical dictionary
Adenine Nucleotide Translocator 1
Summary Report | CureHunter
Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility...
Anti-SLC47A1 / MATE1 Antibody | #ANT-131 | Alomone Labs
MP Antenna 2.4GHz Micro Omni Antenna (08-ANT-0956-BL-G)
291 F.3d 1 | LexRoll.com
Thermogenin - Wikipedia
Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells
AINTEGUMENTA and AINTEGUMENTA-LIKE6 Act Redundantly to Regulate Arabidopsis Floral Growth and Patterning | Plant Physiology
Modeling of ATP-ADP steady-state exchange rate mediated by the adenine nucleotide translocase in isolated mitochondria -...
The biology of mitochondrial uncoupling proteins
ANT1 - Peroxisomal adenine nucleotide transporter 1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) -...
Acute Knockdown of Uncoupling Protein-2 Increases Uncoupling via the Adenine Nucleotide Transporter and Decreases Oxidative...
We have beforehand claimed that glutamate and the adenine nucleotide translocase inhibitor, carboxyatractyloside, ameliorate...
OXPHOS - Adenine Nucleotide Assays and Issues
Crow Calls - Next Sale
Remodeling of the chromatin structure of the facioscapulohumeral muscular dystrophy (FSHD) locus and upregulation of FSHD...
Starvation-Survival Patterns of Sixteen Freshly Isolated Open-Ocean Bacteria | Applied and Environmental Microbiology
Adenine - Drugs.com
Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase<...
Vesicular nucleotide transporter (VNUT): appearance of an actress on the stage of purinergic signaling<...
Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2...
Multiple Deletions in Logistic Regression Models | Korea Science
Ad5-CMV-Ant2 | Seven Hills Bioreagents
Hepatic Adenine Nucleotides and DNA Synthesis during the Regenerative and Atrophic Process of the Liver Lobes after Selective...
Fatty-acid-induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is...
Oxidative Phosphorylation Diseases | The Online Metabolic and Molecular Bases of Inherited Disease | OMMBID | McGraw-Hill...
Author: Suyama, Masaki / Subject: adenosine triphosphate - PubAg Search Results
The effect of calcium on the translocation of adenine nucleotides in rat liver mitochondria. - Semantic Scholar
TWINKLE TWINKLE PATRICK STAR Lyrics - SPONGEBOB SQUAREPANTS | eLyrics.net
Associated Effluxes of Calcium and Adenine Nucleotides from Mitochondria: Mediation by Thyroxine and other Agents, and...
Its Me !!: Twinkle Totz Set Tupperware bayi
AS 25 2 217 218 Tanasevitch et al
Glycerophosphoglycerophosphoglycerols (Cardiolipins) - Glycerophospholipids | Sigma-Aldrich
Adenine nucleotides in snail muscles as one of biomarkers of fluoride toxicity - Journal of Environmental Monitoring (RSC...
High-energy phosphates and related adenine nucleotides. | Open-i
HIV-1 p24 Antibody | Anti HIV1 p24 Monoclonal | ProSpec
Twinkle Twinkle Little Star - interactive songs | Apps | 148Apps
A man ninety years old was asked to what he attributed his longevity. I reckon, he said, with a twinkle in his eye, it because...
Adenine nucleotide translocator
Adenine+Nucleotide+Translocator+2 at the US National Library of Medicine Medical Subject Headings (MeSH) Adenine+Nucleotide+ ... Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or ... Adenine+Nucleotide+Translocator+1 at the US National Library of Medicine Medical Subject Headings (MeSH) ... Pressman BC (June 1958). "Intramitochondrial nucleotides. I. Some factors affecting net interconversions of adenine nucleotides ...
Bcl-2-associated X protein
"Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science. 281 (5385): 2027-31. ... In addition, it can become activated by binding BCL-2, as well as non-BCL-2 proteins such as p53 and Bif-1. Conversely, BAX can ... Weng C, Li Y, Xu D, Shi Y, Tang H (March 2005). "Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related ... 307 (1): 70-5. doi:10.1016/S0003-2697(02)00028-3. PMID 12137781. Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, ...
BCL2L13
Kim JY, So KJ, Lee S, Park JH (Sep 2012). "Bcl-rambo induces apoptosis via interaction with the adenine nucleotide translocator ... Bcl-rambo mediates apoptosis by associating with adenine nucleotide translocator (ANT), a component of the mitochondrial ... 34 (1): 18-23. doi:10.1016/j.leukres.2009.07.023. PMID 20109966. Jensen SA, Calvert AE, Volpert G, Kouri FM, Hurley LA, Luciano ... 534 (1-3): 61-8. doi:10.1016/S0014-5793(02)03778-X. PMID 12527362. S2CID 7018829. Human BCL2L13 genome location and BCL2L13 ...
Sengers syndrome
AGK gene encodes the mitochondrial acylglycerol kinase which plays a role in the assembly of adenine nucleotide translocator. ... There are two forms of the disease: 1. The lethal neonatal form. Hypertrophic cardiomyopathy is diagnosed at birth in half. ... The SLC25A4 gene encodes the heart and muscle-specific isoform 1 of the mitochondrial adenine nucleotide translocator. The ...
CYC1
"Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR ... Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T (April 1988). "Nucleotide sequence of a cDNA ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Valnot I, Kassis J, Chretien D, de Lonlay P, Parfait B, ... 19 (2): 400-1. doi:10.1006/geno.1994.1084. PMID 8188279. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S ( ...
AGK (gene)
AGK also has an implicated role in the assembly of the adenine nucleotide translocator in the inner mitochondrial membrane. ... 108 (1): 40-50. doi:10.1016/j.ymgme.2012.11.282. PMID 23266196. Nouh MA, Wu XX, Okazoe H, Tsunemori H, Haba R, Abou-Zeid AM, ... ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate. The enzyme is involved in the more general pathway of ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano ...
List of MeSH codes (D12.776)
... adenine nucleotide translocator 2 MeSH D12.776.575.750.500.300 - adenine nucleotide translocator 3 MeSH D12.776.580.210.175.325 ... adenine nucleotide translocator 1 MeSH D12.776.575.750.500.200 - ... neuregulin-1 See List of MeSH codes (D12.776.476). MeSH D12.776 ... cofilin 1 MeSH D12.776.220.525.212.750 - cofilin 2 MeSH D12.776.220.525.212.875 - destrin MeSH D12.776.220.525.246.500 - actin- ... hiv-1 reverse transcriptase MeSH D12.776.964.970.880.325 - gene products, env MeSH D12.776.964.970.880.325.330 - hiv envelope ...
ANT1 (disambiguation)
... adenine nucleotide translocator 1) is the most abundant protein in the inner mitochondrial membrane. It is an enzyme that in ...
List of MeSH codes (D12.776.157)
... adenine nucleotide translocator 2 MeSH D12.776.157.530.625.875.500.300 - adenine nucleotide translocator 3 MeSH D12.776.157.530 ... adenine nucleotide translocator 1 MeSH D12.776.157.530.625.875.500.200 - ... nucleotide transport proteins MeSH D12.776.157.530.625.875.500 - mitochondrial adp, atp translocases MeSH D12.776.157.530. ... aryl hydrocarbon receptor nuclear translocator MeSH D12.776.157.530.750.200 - cellular apoptosis susceptibility protein MeSH ...
Y linkage
... adenine nucleotide translocator-3 on the Y), AZF2 (azoospermia factor 2), BPY2 (basic protein on the Y chromosome), AZF1 ( ... family 1, member A1), RBM2 (RNA binding motif protein 2), and UTY (ubiquitously transcribed TPR gene on Y chromosome). USP9Y ... azoospermia factor 1), DAZ (Spermatogenes is deleted in azoospermia), RBM1 (RNA binding motif protein, Y chromosome, ...
List of MeSH codes (D12.776.543)
... adenine nucleotide translocator 2 MeSH D12.776.543.585.450.162.235.300 - adenine nucleotide translocator 3 MeSH D12.776.543.585 ... adenine nucleotide translocator 2 MeSH D12.776.543.585.625.875.500.300 - adenine nucleotide translocator 3 MeSH D12.776.543.585 ... adenine nucleotide translocator 1 MeSH D12.776.543.585.450.162.235.200 - ... adenine nucleotide translocator 1 MeSH D12.776.543.585.625.875.500.200 - ...
ARHGAP11B
... where it binds to the adenine nucleotide translocator. It does not affect the adenine nucleotide exchange activity of the ... A 2016 study suggests, one mutation, a "single nucleotide substitution underlies the specific properties of ARHGAP11B that ... translocator, but it does lead to delayed opening of the mitochondrial permeability transition pore, thus allowing for greater ... In contrast to full-length ARHGAP11A and ARHGAP11A 1-250, ARHGAP11B, like ARHGAP11A1-220, did not exhibit RhoGAP activity in a ...
Apoptosome
... the inner membrane protein adenine nucleotide translocator (AdNT) and the matrix protein cyclophilin D (CyD) (12). This pore ... It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. ... A short linker and nucleotide binding a/b domains (NBD) that contain conserved Walker boxes A (p-loop 155-161) and B (239-243) ... a central nucleotide-binding and oligomerization region (NB-ARC/NOD, 128-586) and a C-terminal WD40 region (613-1248) making up ...
MT-TT
... myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator". ... MT-TT is a small 66 nucleotide RNA (human mitochondrial map position 15888-15953) that transfers the amino acid threonine to a ... 225 (1): 180-5. doi:10.1006/bbrc.1996.1150. PMID 8769114. This article incorporates text from the United States National ...
Thermogenin
UCP1 is very similar to the ATP/ADP Carrier protein, or Adenine Nucleotide Translocator (ANT). The proposed alternating access ... UCP1 is related to other mitochondrial metabolite transporters such as the adenine nucleotide translocator, a proton channel in ... UCP1 is activated in the brown fat cell by fatty acids and inhibited by nucleotides. Fatty acids are released by the following ... overriding the inhibition caused by purine nucleotides (GDP and ADP). During the termination of thermogenesis, thermogenin is ...
TXN2
... thiols in the mitochondrial permeability transition pore component adenine nucleotide translocator (ANT). Overexpression of ... "Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer". Cancer Research. ... 465 (1): 119-26. doi:10.1016/j.abb.2007.05.001. PMID 17548047. Oestergaard MZ, Tyrer J, Cebrian A, Shah M, Dunning AM, Ponder ... Zhou J, Damdimopoulos AE, Spyrou G, Brüne B (Mar 2007). "Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on ...
Ant (disambiguation)
Actor-network theory, an approach to social theory and research Adenine nucleotide translocator Anacamptis (abbreviation Ant), ... ISO 3166-1 alpha-3 country code) River Ant, a river in Norfolk, England Ant (name), English language nickname abbreviated from ...
Substrate-level phosphorylation
... but also to prevent mitochondria from straining glycolytic ATP reserves by maintaining the adenine nucleotide translocator in ' ... "Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level ... "Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues". The Journal of ... 1,3-bisphosphoglycerate is then dephosphorylated via phosphoglycerate kinase, producing 3-phosphoglycerate and ATP through a ...
Mitochondrion
ROS increases uncoupling proteins (UCPs) and potentiate proton leakage through the adenine nucleotide translocator (ANT), the ... One of the two mitochondrial DNA (mtDNA) strands has a disproportionately higher ratio of the heavier nucleotides adenine and ... Nachman MW, Crowell SL (September 2000). "Estimate of the mutation rate per nucleotide in humans". Genetics. 156 (1): 297-304. ... Tumor cells require ample ATP to synthesize bioactive compounds such as lipids, proteins, and nucleotides for rapid ...
Membrane transport protein
Adenine nucleotide translocator (ANT) 2.B: Nonribosomally synthesized porters, such as: The Nigericin family The Ionomycin ... such as rhodopsin The group translocators provide a special mechanism for the phosphorylation of sugars as they are transported ... ISBN 1-4292-1962-9. p. 119. Cooper, Geoffrey (2009). The Cell: A Molecular Approach. Washington, DC: ASM Press. p. 62. ISBN ... ISBN 1-4292-1962-9. p. 119. Ashley, Ruth. Hann, Gary. Han, Seong S. Cell Biology. New Age International Publishers. ISBN ...
Jerzy Duszyński (biochemist)
1982). "Quantification of the role of the adenine nucleotide translocator in the control of mitochondrial respiration in ... The first quantification of the controlling weight of adenine nucleotide transport in cellular bioenergetics. Quantification of ... 1 year, including in Grenoble). The course of his scientific career has been closely linked to the Nencki Institute of ...
Mitochondrial carrier
SLC25A25 adenine nucleotide - SLC25A4, SLC25A5, SLC25A6, SLC25A31 dicarboxylate - SLC25A10 oxoglutarate - SLC25A11 glutamate - ... "Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential". Journal ... Mitochondrial carriers transport amino acids, keto acids, nucleotides, inorganic ions and co-factors through the mitochondrial ... nucleotides, amino acids, keto acids and cofactors across the membrane. Such proteins include: ADP/ATP carrier protein (ADP-ATP ...
Mitochondrial permeability transition pore
Further hypothesis by Halestrap's group convincingly suggested the MPT was formed by the inner membrane Adenine Nucleotide ... "The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore". Nature. 427 (6973): 461-465. doi ... "The nature of the calcium ion efflux induced in rat liver mitochondria by the oxidation of endogenous nicotinamide nucleotides ... "Regulation of the Inner Membrane Mitochondrial Permeability Transition by the Outer Membrane Translocator Protein (Peripheral ...
Identification of an Epitope from Adenine Nucleotide Translocator 1 that Induces Inflammation in Heart in A/J Mice
Role of an adenine-nucleotide translocator in regulation of mitochondrial pyruvate oxidation in the heart. Bulletin of ... Inhibition of the adenine nucleotide translocator by matrix-localized palmityl-CoA in rat heart mitochondria. Biochimica et ... Participation of the adenine nucleotide translocator in the regulation of pyruvate oxidation in heart mitochondria. Biulleten& ... The role of adenine nucleotide translocator in the regulation of oxidative phosphorylation in heart mitochondria. Biokhimiia 53 ...
SLC25A4 gene: MedlinePlus Genetics
The SLC25A4 gene provides the instructions for making a protein called adenine nucleotide translocase type 1 (ANT1). Learn ... Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup. Proc ... Complete loss-of-function of the heart/muscle-specific adenine nucleotide translocator is associated with mitochondrial ... The adenine nucleotide translocase type 1 (ANT1): a new factor in mitochondrial disease. IUBMB Life. 2005 Sep;57(9):607-14. doi ...
Association of novel POLG mutations and multiple mitochondrial DNA deletions with variable clinical phenotypes in a Spanish...
The uncommon phenotype found in 1 of these patients stresses the clinical variability of patients harboring POLG mutations. ... Adenine Nucleotide Translocator 1 * DNA, Mitochondrial * Mitochondrial Proteins * DNA Primase * DNA Polymerase gamma ... 2006 Jan;63(1):107-11. doi: 10.1001/archneur.63.1.107. Authors Emiliano González-Vioque 1 , Alberto Blázquez, Daniel Fernández- ... 1 Departamento de Bioquímica, Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, Universidad Autónoma de Madrid, ...
IJMS | Free Full-Text | Genes and Pathways Involved in Adult Onset Disorders Featuring Muscle Mitochondrial DNA Instability
Adenine nucleotide translocator. AD. Adult. dels. muscle. PEO. TYMP. 22q13. Thymidine phosphorylase. AR. Late childhood ... Role of adenine nucleotide translocator 1 in mtDNA maintenaince. Science 2000, 289, 782-785. [Google Scholar] [CrossRef] [ ... Adenine nucleotide translocator 1 deficiency associated with Sengers syndrome. Ann. Neurol. 2002, 52, 95-99. [Google Scholar] [ ... Dörner, A.; Schultheiss, H.P. Adenine nucleotide translocase in the focus of cardiovascular diseases. Trends Cardiovasc. Med. ...
Facioscapulohumeral Dystrophy: Background, Pathophysiology, Epidemiology
Increased levels of adenine nucleotide translocator 1 protein and response to oxidative stress are early events in ... Misexpression of FRG1 (FSHD region gene 1) may lead to the development of FSHD. Knockdown of FRG1 in Xenopus led to the ... FSHD is considered one of the more common hereditary muscular disorders with a prevalence of ~1 in 8,000. It appears to affect ... FSHD region gene 1 (FRG1) is crucuial for angiogenesis linkinh FRG! to facioscapulohumeral muscular dystrophy-associated ...
Science Clips - Volume 9, Issue 22, June 6, 2017
20 and adenine nucleotide translocator (ANT) 1/2/3/4 that regulate mitochondrial permeability. The results suggest that an ... The isolates were 20 and 26 nucleotide divergent from prototype Sabin strain (with 18 identical mutations) consistent with ... and Candida lusitaniae Targeting rDNA region nucleotide sequences, primers specific for C. auris only or C. auris and related ... Compared to 1-/13-year-olds, a larger percentage of 16-/17-year-olds had parents who discussed their shift to adult care (aPR ...
NIOSHTIC-2 Search Results - Full View
... membrane and in normal operation of other mitochondrial multicomponent machines such as adenine nucleotide translocator, as ... 1 (versus cyt c). Similarly, MCL- and DCL-stimulated peroxidase activity of cyt c could be eliminated by a large excess (versus ... 1) Bid and tBid have a high-affinity binding domain for a mitochondria specific phospholipid, cardiolipin (CL).(2-5) In normal ... 1) an electron shuttle between respiratory complexes III and IV and (2) a scavenger of superoxide anion radicals.(13) Recently ...
MH DELETED MN ADDED MN
Adenine Nucleotide Translocator 2 D12.776.157.530.937.594.200 D12.776.543.585.937.688.200 Adenine Nucleotide Translocator 3 ... Adenine D3.438.759.138 D3.633.100.759.138 Adenine Nucleotide Translocator 1 D12.776.157.530.937.594.100 D12.776.543.585.937.688 ... Adenine Nucleotides D3.438.759.646.138 D3.633.100.759.646.138 Adenosine D3.438.759.590.138 D3.633.100.759.590.138 Adenosine ... Cyclic Nucleotide 3-Phosphodiesterase D12.776.641.580.124 D12.776.631.580.124 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- ...
Viruses as Modulators of Mitochondrial Functions
Viruses like Herpes simplex virus 1 deplete the host mitochondrial DNA and some, like human immunodeficiency virus, hijack the ... H. L. A. Vieira, A. S. Belzacq, D. Haouzi et al., "The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite ... "Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat ... A. S. Belzacq, H. L. A. Vieira, F. Verrier et al., "Bcl-2 and Bax modulate adenine nucleotide translocase activity," Cancer ...
Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity<...
... adenine nucleotide translocator, and ATP synthase] associate with SDH. A purified IM fraction containing these proteins was ... adenine nucleotide translocator, and ATP synthase] associate with SDH. A purified IM fraction containing these proteins was ... adenine nucleotide translocator, and ATP synthase] associate with SDH. A purified IM fraction containing these proteins was ... adenine nucleotide translocator, and ATP synthase] associate with SDH. A purified IM fraction containing these proteins was ...
SustainPineDB
Sma3: Adenine nucleotide translocator 4.049e-24 Complete sp_v3.0_unigene2178 SustainPine v3.0 2079 • AutoFact: Grave disease ... putative mitochondrial phosphate translocator protein [Arabidopsis thaliana] gb,AEC06606.1, phosphate transporter 3;3 [ ... AutoFact: Mitochondrial dicarboxylate carrier protein, putative n=1 Tax=Ricinus communis RepID=B9SXH6_RICCO 6.0e-39 ... AutoFact: ADP,ATP carrier protein, putative n=1 Tax=Ricinus communis RepID=B9RVW7_RICCO 0.0 ...
Search Redox biology as journal on MyScienceWork's publications...
DeCS
Adenine Nucleotide Carrier Protein Adenine Nucleotide Translocator, Muscle Isoform SLC25A4 Protein Solute Carrier Family 25 ( ... Adenine Nucleotide Carrier Protein. Adenine Nucleotide Translocator, Muscle Isoform. SLC25A4 Protein. Solute Carrier Family 25 ... Adenine Nucleotide Translocator 1 - Preferred Concept UI. M0000349. Scope note. A subtype of mitochondrial ADP, ATP translocase ... Adenine Nucleotide Translocator 1 Entry term(s). ANT 1 Transport Protein ANT-1 Transport Protein ANT1 Transport Protein ...
Immune Cell Apoptosis Prevention as Potential Therapy for Severe Infections - Volume 13, Number 2-February 2007 - Emerging...
Weaver JG, Tarze A, Moffat TC, Lebras M, Deniaud A, Brenner C, Inhibition of adenine nucleotide translocator pore function and ... Figure 1. Figure 1. Apoptotic pathways of cell death. The extrinsic pathway is mediated by a variety of death receptor ligands ... The authors of 1 report argued that the beneficial effect of Bcl-2 did not depend on prevention of lymphocyte apoptosis because ... Table 1. Distinguishing features of apoptosis and necrosis * Table 2. Antiapoptotic therapeutic approaches for prevention of ...
Kallikrein 3/PSA Antibody (KLK3/801) (NBP2-44886): Novus Biologicals
Adenine Nucleotide. Translocator 2 Antibo ... NBP2-92630. Species: Hu, Mu, Rt. Applications: ICC/IF, IHC, IHC-P, WB ... Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating ... It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). A higher proportion ... It is predominantly complexed to a liverderived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). A higher proportion ...
IMP: Integrative Multi-species Prediction
研究成果を検索 - Keio University
A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed ... Hirata, M., Hashimoto, Y., Noguchi, S. & Adachi, S., 2010 2月, In: Mechatronics. 20, 1, p. 59-66 8 p.. 研究成果: Article › 査読 ... Oi, S., Saya, H. & Matsumoto, S., 1988 1月 1, In: Journal of neurosurgery. 68, 6, p. 947-954 8 p.. 研究成果: Article › 査読 ... Kanda, T., Kamasima, M., Imai, M., Ono, T., Sakamoto, D., Ishiguro, H. & Anzai, Y., 2007 1月, In: Autonomous Robots. 22, 1, p. ...
SustainPineDB
Adenine nucleotide translocator; Short=ANT gb,AAA33027.1, ATP/ADP translocator [Parachlorella kessleri] 4.0e-32 ... AutoFact: Adenine nucleotide translocator (Fragment) n=1 Tax=Angiostrongylus cantonensis RepID=F5GTH3_9BILA 9.0e-29 ... AutoFact: Glyceraldehyde-3-phosphate dehydrogenase, type I n=1 Tax=Bacteroides coprosuis DSM 18011 RepID=F3ZU50_9BACE 5.0e-24 ... AutoFact: Caffeoyl-CoA O-methyltransferase n=1 Tax=Chamaecyparis obtusa var. formosana RepID=A0S6W3_CHAOB 0.0 ...
尋找研究成果 - 臺北醫學大學
Antimicrobial peptide TP4 targets mitochondrial adenine nucleotide translocator 2. Su, B. C., Liu, Y. C., Ting, C. H., Lyu, P. ... Burnouf, T., Chou, M. L., Wu, Y. W., Su, C. Y. & Lee, L. W., 1月 2013, 於: Transfusion. 53, 1, p. 138-146 9 p.. 研究成果: 雜誌貢獻 › 文章 ... Zhang, J., Li, R. K., Chen, K. H., Ge, L. & Tian, J. H., 1月 2016, 於: BMJ Open. 6, 1, e010264.. 研究成果: 雜誌貢獻 › 文章 › 同行評審 ... Wu, C. J., Sheu, J. R., Chen, H. H., Shyur, S. D., Chen, P. G. & Chen, Y. J., 2003, 於: Neoplasma. 50, 1, p. 54-59 6 p..
KEGG ORTHOLOGY: K05863
K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. 04022 cGMP-PKG ... K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. 09160 Human ... K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. 05020 Prion ... K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. 09180 Brite ...
Antiandrogen-induced cell death in LNCaP human prostate cancer cells | Cell Death & Differentiation
... been shown to increase its cytotoxicity and has been implicated in facilitating the assemble of adenine nucleotide translocator ... Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator ... Figure 1. Effects of TNF-α and Casodex on cell adhesiveness, mitochondrial dehydrogenase activities and mitochondrial membrane ... Cytosolic extracts of WT LNCaP cells (1 × 106 cells) treated with control vehicle, 10 ng/ml TNF-α or 100 μM Casodex for 48 h in ...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 Adenine Nucleotide Translocator 3 ... D9.408.477.410 Kangai-1 Protein D12.776.395.550.465 D12.776.395.550.16 D12.776.543.550.462 D12.776.543.550.182 D12.776.624.776. ... E5.200.812.735.50.450 LDL-Receptor Related Protein 1 D23.50.301.264.35.502 D23.101.100.110.498 (Replaced for 2012 by Low ... D12.776.92.500.925 Voltage-Dependent Anion Channel 1 D12.776.543.585.475.750 D12.776.575.750.750 Voltage-Dependent Anion ...
MH DELETED MN ADDED MN
Adenine Nucleotide Translocator 2 D12.776.157.530.937.594.200 D12.776.543.585.937.688.200 Adenine Nucleotide Translocator 3 ... Adenine D3.438.759.138 D3.633.100.759.138 Adenine Nucleotide Translocator 1 D12.776.157.530.937.594.100 D12.776.543.585.937.688 ... Adenine Nucleotides D3.438.759.646.138 D3.633.100.759.646.138 Adenosine D3.438.759.590.138 D3.633.100.759.590.138 Adenosine ... Cyclic Nucleotide 3-Phosphodiesterase D12.776.641.580.124 D12.776.631.580.124 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- ...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 Adenine Nucleotide Translocator 3 ... D9.408.477.410 Kangai-1 Protein D12.776.395.550.465 D12.776.395.550.16 D12.776.543.550.462 D12.776.543.550.182 D12.776.624.776. ... E5.200.812.735.50.450 LDL-Receptor Related Protein 1 D23.50.301.264.35.502 D23.101.100.110.498 (Replaced for 2012 by Low ... D12.776.92.500.925 Voltage-Dependent Anion Channel 1 D12.776.543.585.475.750 D12.776.575.750.750 Voltage-Dependent Anion ...
MH DELETED MN ADDED MN
Adenine Nucleotide Translocator 2 D12.776.157.530.937.594.200 D12.776.543.585.937.688.200 Adenine Nucleotide Translocator 3 ... Adenine D3.438.759.138 D3.633.100.759.138 Adenine Nucleotide Translocator 1 D12.776.157.530.937.594.100 D12.776.543.585.937.688 ... Adenine Nucleotides D3.438.759.646.138 D3.633.100.759.646.138 Adenosine D3.438.759.590.138 D3.633.100.759.590.138 Adenosine ... Cyclic Nucleotide 3-Phosphodiesterase D12.776.641.580.124 D12.776.631.580.124 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- ...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 Adenine Nucleotide Translocator 3 ... D9.408.477.410 Kangai-1 Protein D12.776.395.550.465 D12.776.395.550.16 D12.776.543.550.462 D12.776.543.550.182 D12.776.624.776. ... E5.200.812.735.50.450 LDL-Receptor Related Protein 1 D23.50.301.264.35.502 D23.101.100.110.498 (Replaced for 2012 by Low ... D12.776.92.500.925 Voltage-Dependent Anion Channel 1 D12.776.543.585.475.750 D12.776.575.750.750 Voltage-Dependent Anion ...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 Adenine Nucleotide Translocator 3 ... D9.408.477.410 Kangai-1 Protein D12.776.395.550.465 D12.776.395.550.16 D12.776.543.550.462 D12.776.543.550.182 D12.776.624.776. ... E5.200.812.735.50.450 LDL-Receptor Related Protein 1 D23.50.301.264.35.502 D23.101.100.110.498 (Replaced for 2012 by Low ... D12.776.92.500.925 Voltage-Dependent Anion Channel 1 D12.776.543.585.475.750 D12.776.575.750.750 Voltage-Dependent Anion ...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 Adenine Nucleotide Translocator 3 ... D9.408.477.410 Kangai-1 Protein D12.776.395.550.465 D12.776.395.550.16 D12.776.543.550.462 D12.776.543.550.182 D12.776.624.776. ... E5.200.812.735.50.450 LDL-Receptor Related Protein 1 D23.50.301.264.35.502 D23.101.100.110.498 (Replaced for 2012 by Low ... D12.776.92.500.925 Voltage-Dependent Anion Channel 1 D12.776.543.585.475.750 D12.776.575.750.750 Voltage-Dependent Anion ...
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 Adenine Nucleotide Translocator 3 ... D9.408.477.410 Kangai-1 Protein D12.776.395.550.465 D12.776.395.550.16 D12.776.543.550.462 D12.776.543.550.182 D12.776.624.776. ... E5.200.812.735.50.450 LDL-Receptor Related Protein 1 D23.50.301.264.35.502 D23.101.100.110.498 (Replaced for 2012 by Low ... D12.776.92.500.925 Voltage-Dependent Anion Channel 1 D12.776.543.585.475.750 D12.776.575.750.750 Voltage-Dependent Anion ...
ANT13
- In support of this notion, intracellular cardiac antigens, like cardiac myosin heavy chain-α, cardiac troponin-I, and adenine nucleotide translocator 1 (ANT1), have been identified as autoantigens in cardiac autoimmunity. (eurekamag.com)
- The SLC25A4 gene provides the instructions for making a protein called adenine nucleotide translocase type 1 (ANT1). (medlineplus.gov)
- Adenine nucleotide translocator 1 (ANT1), the only 4q35 gene involved in mitochondrial function, is strongly expressed in FSHD skeletal muscle biopsies. (mysciencework.com)
Mitochondrial Proteins4
- Viruses like Herpes simplex virus 1 deplete the host mitochondrial DNA and some, like human immunodeficiency virus, hijack the host mitochondrial proteins to function fully inside the host cell. (hindawi.com)
- Although the majority of the mitochondrial proteins are encoded by nuclear DNA and imported into the mitochondria (reviewed by [ 21 , 28 - 31 ]), mitochondria synthesize few proteins that are essential for their respiratory function [ 1 , 27 ]. (hindawi.com)
- Four mitochondrial proteins [mitochondrial ATP-binding cassette protein 1 (mABC1), phosphate carrier, adenine nucleotide translocator, and ATP synthase] associate with SDH. (elsevier.com)
- 2013). Additionally, decreases in cellular PA may also destabilize the assembly of the adenine nucleotide translocators (ANTs), a subset of highly abundant mitochondrial proteins essential for ADP/ATP translocation across the mitochondrial inner membrane (Mayr et al. (preventiongenetics.com)
Phosphate2
- It plays a very important role in the assembly and maintenance of functionally active respiratory complexes (I, III and IV and F0/F1-ATPase) in the mitochondrial membrane and in normal operation of other mitochondrial multicomponent machines such as adenine nucleotide translocator, as well as tricarboxylate, pyruvate and phosphate carriers. (cdc.gov)
- undecaprenyl pyrophosphate:lipid A 1-phosphate phosphotransferase [Ensembl]. (ntu.edu.sg)
Fragment1
- the shortened Eco RI fragment in FSHD is 1-10 units. (medscape.com)
Phosphoribosyltransferase1
- adenine phosphoribosyltransferase [Sou. (gsea-msigdb.org)
Gene1
- Misexpression of FRG1 (FSHD region gene 1) may lead to the development of FSHD. (medscape.com)
Carrier1
- The 18 kDa translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is a hetero-oligomeric complex comprising the voltage-dependent anion channel as well as an adenine nucleotide carrier found in both the periphery and the brain [ 1 - 4 ]. (biomedcentral.com)
Peptide1
- The 824 amino acid precursor of human ADAM8 consists of a signal peptide (residues 1 to 16), a pro peptide (residues 17 to 199), a metaloprotease domain (residues 200 to 400), a disintegrin-like domain (residues 408 to 494), a cysteine-rich region (residues 497 to 613), an EGF-like domain (residues 614 to 640), a transmembrane region (residues 656 to 676) and a cytoplasmic domain (residues 677 to 824). (novusbio.com)
Subunit1
- HEXIM P-TEFb complex subunit 1 [Source. (gsea-msigdb.org)
Putative1
- XV" YOL105C 1 15 18 YOL105C "Putative integral membrane protein containing novel cysteine motif. (davidson.edu)
Mitochondria7
- 1) Bid and tBid have a high-affinity binding domain for a mitochondria specific phospholipid, cardiolipin (CL). (cdc.gov)
- 4,12) Cyt c is an important contributor to redox reactions in the intermembrane space of mitochondria where it functions as (1) an electron shuttle between respiratory complexes III and IV and (2) a scavenger of superoxide anion radicals. (cdc.gov)
- 1) Electron microscope studies have shown abnormalities in the mitochondria of cancer cells. (greenmedinfo.com)
- All of the Group B patients were found have sub-normal TL IN values (ie, they have reduced translocator protein transfer of ATP from mitochondria to the cytosol of the cell). (phoenixrising.me)
- And 78% of the Group B patients have sub-normal values of TL OUT (decreased translocator protein ferrying of ADP from the cell to the mitochondria). (phoenixrising.me)
- Does TL refer to the translocator protein transfer of ATP from mitochondria to the cytosol of the cell? (phoenixrising.me)
- The translocator protein (TL) has two functions and is a two-way street: it carries fresh ATP from the mitochondria into the rest of the cell (this Myhill calls TL IN), and also carries the spent ATP (it becomes ADP once spent) back out from the cell into the mitochondria for recycling (TL OUT). (phoenixrising.me)
Homolog1
- DNA damage inducible 1 homolog 2 [Sour. (gsea-msigdb.org)
Member2
- ADAM8, also known as cell surface antigen MS2 or CD156a, is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain (1, 2). (novusbio.com)
- GTPase, IMAP family member 1 [Source:H. (gsea-msigdb.org)
Apoptosis1
- 1 Casodex, an antiandrogen used in prostate cancer therapy, is designed to reduce tumor size by interfering with normal androgen receptor (AR)-mediated processes that ensure prostate cell survival and by triggering tumor cells to undergo apoptosis. (nature.com)
Primary Antibodies1
- Primary Antibodies are guaranteed for 1 year from date of receipt. (novusbio.com)
Term1
- Note that Myhill et al use the term 'translocator protein' to refer to the adenine nucleotide translocator (ANT). (phoenixrising.me)
Lysine1
- MINDY lysine 48 deubiquitinase 1 [Sour. (gsea-msigdb.org)
Methyltransferase2
- Caffeoyl-CoA O-methyltransferase n=1 Tax=Chamaecyparis obtusa var. (uma.es)
- tRNA (Guanine-1)-methyltransferase [Interproscan]. (ntu.edu.sg)
Cullin1
- defective in cullin neddylation 1 doma. (gsea-msigdb.org)
Receptor1
- RESULTS: GDNF-RET signaling formed a positive feedback loop with EGR1 and also downregulated estrogen receptor 1 (ESR1) transcription. (bvsalud.org)
Serine1
- It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). (novusbio.com)
HUMAN3
- In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse ADAM8 is observed and less than 1% cross-reactivity with recombinant human (rh) ADAM12, rhADAM19, and rhADAM33 is observed. (novusbio.com)
- We studied the distribution and expression of translocator protein in the human brain using 11 C-[R]-PK-11195 positron emission tomography (PK11195 PET) and evaluated age-related changes. (biomedcentral.com)
- Description: RAB5C Human Recombinant produced in E. coli is a single polypeptide chain containing 239 amino acids (1-216) and having a molecular mass of 25.9kDa. (hiv-pharmacogenomics.org)
Transcription1
- We recently reported that glial cell-derived neurotrophic factor (GDNF)-RET signaling appears to promote a positive feedback loop with the transcription factor early growth response 1 (EGR1). (bvsalud.org)
Found1
- The uncommon phenotype found in 1 of these patients stresses the clinical variability of patients harboring POLG mutations. (nih.gov)
Structures1
- The brain shows low PK11195 uptake, which is lower in the cortex and cerebellum compared with subcortical structures, suggesting a low level of translocator protein expression. (biomedcentral.com)
Source4
- In growing plants, sucrose is the most widespread sugar used to supply both carbon and energy from 'source' tissues (e.g. autotrophic mesophyll) to 'sink' tissues (e.g. heterotrophic roots, growing shoots or reproductive organs) to build up a biomass [ 1 ]. (biomedcentral.com)
- angiopoietin like 1 [Source:HGNC Symbo. (gsea-msigdb.org)
- debranching RNA lariats 1 [Source:HGNC. (gsea-msigdb.org)
- extracellular matrix protein 1 [Source. (gsea-msigdb.org)
Cancer1
- 1) Dr. Seyfried says: "cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. (greenmedinfo.com)
Expression2
- This increase in uptake suggests an age-related increase in translocator protein expression or the number of cells expressing these receptors or both. (biomedcentral.com)
- Additionally, we show that rGDNF treatment activated GDNF-RET signaling in TamS cells, leading to recruitment of phospho-ELK-1 to the EGR1 promoter, upregulation of EGR1 mRNA and protein, binding of EGR1 to the GDNF and CCND1 promoters, increased GDNF protein expression, and subsequent upregulation of CCND1 mRNA levels. (bvsalud.org)
Cell2
- This process is an apparent acceleration or dysregulation of the same process by which these cell populations are regulated during normal health ( 1 , 2 ). (cdc.gov)
- Giant cell arteritis (GCA) is a granulomatous disease that displays tissue tropism for large and medium arteries manifesting as aortitis and vasculitis of the second to fifth branches of the aorta [ 1 ]. (biomedcentral.com)
Patients2
- Five patients with PEO had mutations: 2 were compound heterozygotes, 1 was homozygous, and another showed a mutation in a single allele. (nih.gov)
- Those without FSHD have approximately 11-100 D4Z4 units, whereas patients with FSHD have 1-10 D4Z4 units. (medscape.com)
Complex2
- tBid almost completely inhibited the peroxidase activity of CL/cyt c complex only at ratios exceeding 20 : 1 (versus cyt c). (cdc.gov)
- Many download Encountering Nature only regulates epithelium place from -ATPase and may be a differential planned weight in features Ligand-binding unique fertility, not its multiple-nucleotide initiates recognized directly although the addition of ARG2 under citric complex infections promotes limited. (erik-mill.de)