AnatomyChemicals and DrugsPhenomena and ProcessesInformation Science
Adenine Nucleotide Translocator 1Mitochondrial ADP, ATP TranslocasesAdenine Nucleotide Translocator 2AtractylosideBongkrekic AcidAdenine NucleotidesAdenine Nucleotide Translocator 3Oxidative PhosphorylationMitochondriaMitochondria, LiverNucleotidyltransferasesIntracellular MembranesAdenosine DiphosphateAdenosine TriphosphateVoltage-Dependent Anion ChannelsMitochondrial Membrane Transport ProteinsMitochondrial SwellingMitochondria, HeartAdenineOxygen ConsumptionCyclophilinsMembrane Potential, MitochondrialUncoupling AgentsCell RespirationPermeabilityAryl Hydrocarbon Receptor Nuclear TranslocatorProto-Oncogene Proteins c-bcl-2Mitochondrial ProteinsNucleotidesMolecular Sequence DataApoptosisMembrane PotentialsKineticsDNA, MitochondrialAdenosine MonophosphateMyocardiumReceptors, GABAReceptors, Aryl HydrocarbonEnergy MetabolismPurine NucleotidesAmino Acid SequenceGuanine NucleotidesAdenosineBase SequenceHypoxanthines
Adenine Nucleotide Translocator 1
A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).
Mitochondrial ADP, ATP Translocases
A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization.
Adenine Nucleotide Translocator 2
A subtype of mitochondrial ADP, ATP translocase found primarily in FIBROBLASTS.
Atractyloside
A glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEPIS. Toxicity is due to inhibition of ADENINE NUCLEOTIDE TRANSLOCASE.
Bongkrekic Acid
An antibiotic produced by Pseudomonas cocovenenans. It is an inhibitor of MITOCHONDRIAL ADP, ATP TRANSLOCASES. Specifically, it blocks adenine nucleotide efflux from mitochondria by enhancing membrane binding.
Adenine Nucleotides
Adenine Nucleotide Translocator 3
A subtype of mitochondrial ADP, ATP translocase found primarily in the LIVER.
Oxidative Phosphorylation
Electron transfer through the cytochrome system liberating free energy which is transformed into high-energy phosphate bonds.
Mitochondria
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Mitochondria, Liver
Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)
Nucleotidyltransferases
A class of enzymes that transfers nucleotidyl residues. EC 2.7.7.
Intracellular Membranes
Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.
Adenosine Diphosphate
Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Adenosine Triphosphate
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Voltage-Dependent Anion Channels
A family of voltage-gated eukaryotic porins that form aqueous channels. They play an essential role in mitochondrial CELL MEMBRANE PERMEABILITY, are often regulated by BCL-2 PROTO-ONCOGENE PROTEINS, and have been implicated in APOPTOSIS.
Mitochondrial Membrane Transport Proteins
Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.
Mitochondrial Swelling
An increase in MITOCHONDRIAL VOLUME due to an influx of fluid; it occurs in hypotonic solutions due to osmotic pressure and in isotonic solutions as a result of altered permeability of the membranes of respiring mitochondria.
Mitochondria, Heart
The mitochondria of the myocardium.
Adenine
A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
Oxygen Consumption
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Cyclophilins
A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-
Membrane Potential, Mitochondrial
The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.
Uncoupling Agents
Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.
Cell Respiration
The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell.
Permeability
Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.
Aryl Hydrocarbon Receptor Nuclear Translocator
Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with DIOXIN RECEPTOR. The complex binds xenobiotic regulatory elements and activates transcription of a variety of genes including UDP GLUCURONOSYLTRANSFERASE. AhR nuclear translocator is also a subunit of HYPOXIA-INDUCIBLE FACTOR 1.
Proto-Oncogene Proteins c-bcl-2
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
Mitochondrial Proteins
Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.
Nucleotides
The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Membrane Potentials
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Kinetics
The rate dynamics in chemical or physical systems.
DNA, Mitochondrial
Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.
Adenosine Monophosphate
Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
Myocardium
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Receptors, GABA
Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.
Receptors, Aryl Hydrocarbon
Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.
Energy Metabolism
The chemical reactions involved in the production and utilization of various forms of energy in cells.
Purine Nucleotides
Purines attached to a RIBOSE and a phosphate that can polymerize to form DNA and RNA.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Guanine Nucleotides
Adenosine
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Hypoxanthines
Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.

Induction of an unregulated channel by mutations in adenine nucleotide translocase suggests an explanation for human ophthalmoplegia. (1/69)

Adenine nucleotide translocase (Ant) is primarily involved in ATP/ADP exchange across the mitochondrial inner membrane. Recently, the A114P missense mutation in the human Ant1 protein was found to be associated with autosomal dominant progressive external ophthalmoplegia (adPEO). Ant1(A114P) was proposed to cause an imbalance of the mitochondrial deoxynucleotide pool that subsequently affects the accuracy of mtDNA replication, thereby leading to accumulation of mutant mtDNA. In the present study, it has been shown that the A128P mutation of the Saccharomyces cerevisiae Aac2 protein, equivalent to A114P in human Ant1p, does not always affect respiratory growth. However, expression of aac2(A128P) results in depolarization, structural swelling and disintegration of mitochondria, and ultimately an arrest of cell growth in a dominant-negative manner. The aac2(A128P) mutation likely induces an unregulated channel allowing free passage of solutes across the inner membrane. These data raise the possibility that the formation of an unregulated channel, rather than a defect in ATP/ADP exchange, is a direct pathogenic factor in human adPEO. The accumulation of mtDNA mutations might be a consequence of mitochondrial dysfunction.  (+info)

Skeletal muscle mitochondrial free-fatty-acid content and membrane potential sensitivity in different thyroid states: involvement of uncoupling protein-3 and adenine nucleotide translocase. (2/69)

The effect of triiodothyronine (T3) on mitochondrial efficiency could be related to an increase in the concentrations of some proteins, such as uncoupling proteins (UCPs). Free fatty acids (FFA) seem to be a cofactor essential for the uncoupling activity of UCP3. In this paper, we report that the hypothyroidism-hyperthyroidism transition is accompanied by increases: (i) in the endogenous levels of mitochondrial FFA and (ii) in the sensitivity to FFA shown by the mitochondrial respiration rate and membrane potential, which correlated with the level of UCP3 protein. The level of the mRNA for adenine-nucleotide translocase-1 (ANT) was not affected by the thyroid state, while the ANT contribution to FFA-induced changes in mitochondrial uncoupling was low in the hypothyroid and euthyroid states but became more relevant in the hyperthyroid state at the highest concentration of FFA.  (+info)

Hypothermia preserves myocardial function and mitochondrial protein gene expression during hypoxia. (3/69)

Hypothermia before and/or during no-flow ischemia promotes cardiac functional recovery and maintains mRNA expression for stress proteins and mitochondrial membrane proteins (MMP) during reperfusion. Adaptation and protection may occur through cold-induced change in anaerobic metabolism. Accordingly, the principal objective of this study was to test the hypothesis that hypothermia preserves myocardial function during hypoxia and reoxygenation. Hypoxic conditions in these experiments were created by reducing O2 concentration in perfusate, thereby maintaining or elevating coronary flow (CF). Isolated Langendorff-perfused rabbit hearts were subjected to perfusate (Po2 = 38 mmHg) with glucose (11.5 mM) and perfusion pressure (90 mmHg). The control (C) group was at 37 degrees C for 30 min before and 45 min during hypoxia, whereas the hypothermia (H) group was at 29.5 degrees C for 30 min before and 45 min during hypoxia. Reoxygenation occurred at 37 degrees C for 45 min for both groups. CF increased during hypoxia. The H group markedly improved functional recovery during reoxygenation, including left ventricular developed pressure (DP), the product of DP and heart rate, dP/dtmax, and O2 consumption (MVo2) (P < 0.05 vs. control). MVo2 decreased during hypothermia. Lactate and CO2 gradients across the coronary bed were the same in C and H groups during hypoxia, implying similar anaerobic metabolic rates. Hypothermia preserved MMP betaF1-ATPase mRNA levels but did not alter adenine nucleotide translocator-1 or heat shock protein-70 mRNA levels. In conclusion, hypothermia preserves cardiac function after hypoxia in the hypoxic high-CF model. Thus hypothermic protection does not occur exclusively through cold-induced alterations in anaerobic metabolism.  (+info)

Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling. (4/69)

Identification of factors regulating cardiomyocyte survival and growth is important to understand the pathogenesis of congenital heart diseases. Little is known about the molecular mechanism of cardiac functions triggered by serotonin. The link between signaling circuitry of external stimuli and the mitochondrial apoptotic machinery is of wide interest in cardiac diseases. Using cultured cardiomyocytes and 5-hydroxytryptamine (5-HT)2B-receptor knockout mice as an animal model of dilated cardiomyopathy, for the first time we show that serotonin via the Gq-coupled 5-HT2B-receptor protect cardiomyocytes against serum deprivation-induced apoptosis as manifested by DNA fragmentation, nuclear chromatin condensation, and TUNEL labeling. Serotonin prevents cytochrome c release and caspase-9 and -3 activation after serum deprivation via cross-talks between phosphatidylinositol-3 kinase/Akt and extracellular signal-regulated kinase (ERK) 1/2 signaling pathways. Serotonin binding to 5-HT2B-receptor activates ERK kinases to inhibit Bax expression induced by serum deprivation. Serotonin via phosphatidylinositol-3 kinase/Akt can activate NF-kappaB that is required for the regulation of the mitochondrial adenine nucleotide translocator (ANT-1). Parallel to these observations, ultrastructural analysis in the 5-HT2B-receptor knockout mice heart revealed pronounced mitochondrial defects in addition to altered mitochondrial enzyme activities (cytochrome oxidase and succinate dehydrogenase) and ANT-1 and Bax expressions. These findings identify 5-HT as a novel survival factor targeting mitochondria in cardiomyocytes.  (+info)

A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells. (5/69)

Mitochondria are the powerhouse of the cell and their disruption leads to cell death. We have used a peptide trivalent arsenical, 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO), to inactivate the adenine nucleotide translocator (ANT) that exchanges matrix ATP for cytosolic ADP across the inner mitochondrial membrane and is the key component of the mitochondrial permeability transition pore (MPTP). GSAO triggered Ca(2+)-dependent MPTP opening by crosslinking Cys(160) and Cys(257) of ANT. GSAO treatment caused a concentration-dependent increase in superoxide levels, ATP depletion, mitochondrial depolarization, and apoptosis in proliferating, but not growth-quiescent, endothelial cells. Endothelial cell proliferation drives new blood vessel formation, or angiogenesis. GSAO inhibited angiogenesis in the chick chorioallantoic membrane and in solid tumors in mice. Consequently, GSAO inhibited tumor growth in mice with no apparent toxicity at efficacious doses.  (+info)

Increased adenine nucleotide translocator 1 in reactive astrocytes facilitates glutamate transport. (6/69)

A hallmark of central nervous system (CNS) pathology is reactive astrocyte production of the chronic glial scar that is inhibitory to neuronal regeneration. The reactive astrocyte response is complex; these cells also produce neurotrophic factors and are responsible for removal of extracellular glutamate, the excitatory neurotransmitter that rises to neurotoxic levels in injury and disease. To identify genes expressed by reactive astrocytes, we employed an in vivo model of the glial scar and differential display PCR and found an increase in the level of Ant1, a mitochondrial ATP/ADP exchanger that facilitates the flux of ATP out of the mitochondria. Ant1 expression in reactive astrocytes is regulated by transforming growth factor-beta1, a pluripotent CNS injury-induced cytokine. The significance of increased Ant1 is evident from the observation that glutamate uptake is significantly decreased in astrocytes from Ant1 null mutant mice while a specific Ant inhibitor reduces glutamate uptake in wild-type astrocytes. Thus, the astrocytic response to CNS injury includes an apparent increase in energy mobilization capacity by Ant1 that contributes to neuroprotective, energy-dependent glutamate uptake.  (+info)

Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity. (7/69)

Mitochondrial permeability transition (MPT) has been proposed to play a key role in cell death. Downstream MPT events include the release of apoptogenic factors that sets in motion the mitochondrial apoptosome leading to caspase activation. The current work examined the regulation of MPT by membrane fluidity modulated upon cholesterol enrichment. Mitochondria enriched in cholesterol displayed increased microviscosity resulting in impaired MPT induced by atractyloside, a c-conformation stabilizing ligand of the adenine nucleotide translocator (ANT). This effect was dependent on the dose of cholesterol loaded and reversed upon the fluidization of mitochondria by the fatty acid derivative A2C. Mitoplasts derived from cholesterol-enriched mitochondria responded to atractyloside in a similar fashion as intact mitochondria, indicating that a significant amount of cholesterol is still found in the inner membrane. The effects of cholesterol on MPT induced by atractyloside were mirrored by the release of intermembrane proteins, cytochrome c, Smac/Diablo, and apoptosis inducing factor. However, cholesterol loading did not affect the uptake rate of adenine nucleotide hence dissociating the function of ANT as a MPT-mediated protein from its adenine nucleotide exchange function. Thus, these findings indicate that the ability of atractyloside to induce MPT via ANT requires an appropriate membrane fluidity range.  (+info)

Protein components of mitochondrial DNA nucleoids in higher eukaryotes. (8/69)

Mitochondrial DNA (mtDNA) is not packaged in nucleosomal particles, but has been reported to associate with the mitochondrial inner membrane. Gentle lysis of Xenopus oocyte mitochondria with nonionic detergent liberates a nucleoprotein complex containing mtDNA associated with a previously characterized DNA binding partner, mitochondrial transcription factor A (mtTFA), as well as a series of inner membrane proteins identified by sequencing. More extensive detergent treatment stripped most of these proteins from the DNA, leaving a limited number of proteins in a nucleoid core. Sequencing of the major proteins retained in association with mtDNA revealed the expected mtDNA binding proteins, mtTFA and mitochondrial single-stranded DNA binding protein (mtSSB), as well as four proteins not previously reported to associate with mtDNA. These include adenine nucleotide translocator 1, the lipoyl-containing E2 subunits of pyruvate dehydrogenase and branched chain alpha-ketoacid dehydrogenase and prohibitin 2. The association of several of these proteins with mtTFA-containing mtDNA nucleoids was confirmed by immunoprecipitation.  (+info)

Adenine nucleotide translocator synonyms, Adenine nucleotide translocator antonyms - FreeThesaurus.comAdenine nucleotide translocator synonyms, Adenine nucleotide translocator antonyms - FreeThesaurus.com
Synonyms for Adenine nucleotide translocator in Free Thesaurus. Antonyms for Adenine nucleotide translocator. 1 synonym for adenine: A. What are synonyms for Adenine nucleotide translocator?
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Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2...Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2...
In brown-fat mitochondria, fatty acids induce thermogenic uncoupling through activation of UCP1 (uncoupling protein 1). However, even in brown-fat mitochondria from UCP1−/− mice, fatty-acid-induced uncoupling exists. In the present investigation, we used the inhibitor CAtr (carboxyatractyloside) to examine the involvement of the ANT (adenine nucleotide translocator) in the mediation of this UCP1-independent fatty-acid-induced uncoupling in brown-fat mitochondria. We found that the contribution of ANT to fatty-acid-induced uncoupling in UCP1−/− brown-fat mitochondria was minimal (whereas it was responsible for nearly half the fatty-acid-induced uncoupling in liver mitochondria). As compared with liver mitochondria, brown-fat mitochondria exhibit a relatively high (UCP1-independent) basal respiration (proton leak). Unexpectedly, a large fraction of this high basal respiration was sensitive to CAtr, whereas in liver mitochondria, basal respiration was CAtr-insensitive. Total ANT protein ...
https://portlandpress.com/biochemj/article-abstract/399/3/405/41792/Carboxyatractyloside-effects-on-brown-fat
Slc25a13 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 ...
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Slc25a4 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 (cDNA...
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Selleck Chemicals Blog-Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cellsSelleck Chemicals Blog-Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells
The colorectal cancer (CRC) is one leading contributor of cancer-related mortality worldwide. The search for effective anti-CRC agents is valuable. In the current study, we showed that icaritin (ICT), an active natural ingredient from the Chinese plant Epimedium, potently inhibited proliferation and survival of established (HT-29, HCT-116, DLD-1, and SW-620) and primary (patient-derived) CRC cells. Significantly, ICT mainly induced necrosis, but not apoptosis, in CRC cells. The necrosis inhibitor necrostatin-1 attenuated ICT-mediated cytotoxicity in CRC cells. We showed that ICT treatment in CRC cells induced mitochondrial permeability transition pore (mPTP) opening, which was evidenced by mitochondrial membrane potential (MMP) decrease and mitochondrial adenine nucleotide translocator-1 (ANT-1)-cyclophilin-D (CyPD) association. On the other hand, mPTP blockers, including sanglifehrin A, cyclosporin A, and bongkrekic acid, as well as siRNA-mediated knockdown of mPTP component (CyPD or ANT-1), ...
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Anti-Adenine Nucleotide Translocator 2 antibody (ab118125)Anti-Adenine Nucleotide Translocator 2 antibody (ab118125)
Rabbit polyclonal Adenine Nucleotide Translocator 2 antibody validated for WB, IP and tested in Human. With 2 independent reviews. Immunogen corresponding to…
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Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) |...Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) |...
Diabetes increases myocardial FA oxidation and MVO2, but underlying mechanisms are partially understood. We used perfused hearts, permeabilized fibers (fibers) and isolated mitochondria from diabetic db/db mice to assess mitochondrial (MITO) uncoupling and to elucidate underlying molecular mechanisms. MITO uncoupling and reduced cardiac efficiency (CE) was absent in hearts perfused with glucose alone. However, in db/db hearts perfused with 1.0 mM Palmitate and 11mM glucose, RPP was reduced by 31% p, 0.02, MVO2 was increased by 45% p, 0.03, and CE reduced by 51% p,0.004. In fibers, state 3 respirations with palmitoyl carnitine were similar (16.4±1.3 and 16.7±1.5 nmol/min/mg), but ATP production rates were reduced by 36% in db/db fibers so that ATP/O ratios were 1.5±0.2 in db/db vs. 2.5±0.1 in controls (p,0.005), indicating FA-induced mitochondrial uncoupling. H2O2 production was also increased by 2.6 fold (p,0.001) in isolated db/db MITO exposed to the complex 1 substrate pyruvate. To ...
http://circ.ahajournals.org/content/114/Suppl_18/II_244.5
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Graham BH et al. (1997) A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator.. [^] ...
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Adenine Nucleotide Translocator 1 Summary Report | CureHunterAdenine Nucleotide Translocator 1 Summary Report | CureHunter
Adenine Nucleotide Translocator 1: A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).
http://www.curehunter.com/public/keywordSummaryD033741-Adenine-Nucleotide-Translocator-1.do
Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility...Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility...
The four known human ANT isoforms (ANT1, ANT2, ANT3, and ANT4) exhibit tissue-, cell-type-, and developmental stage-specific expression patterns [18]. ANT1 is strongly expressed in terminally differentiated cells; ANT2 is overexpressed in tissues that have high proliferative ability and in several cancer cell lines [16, 21]; and ANT3 is ubiquitously expressed in all tissues. Whereas ANT1 and ANT3 exert pro-apoptotic effects when overexpressed, ANT2, instead, has an anti-apoptotic function [20, 28]. We previously observed that ANT2 is overexpressed in the breast cancer cell lines MCF7 and MDA-MB-231 but is absent from the non-neoplastic mammary epithelial cell line MCF10A [16]. Moreover, vector-based RNAi knockdown of ANT2 expression in MCF7 and MDA-MB-231 cells resulted in cell cycle arrest and apoptotic cell death; these events were accompanied by cellular energy (ATP) depletion, mitochondrial membrane depolarization, Bax induction, and Bcl-xL down-regulation [16]. TNF-α and TNF receptor I ...
https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-9-262
Anti-SLC47A1 / MATE1 Antibody | #ANT-131 | Alomone LabsAnti-SLC47A1 / MATE1 Antibody | #ANT-131 | Alomone Labs
Anti-SLC47A1 Antibody from Alomone Labs is a highly specific rabbit polyclonal Ab directed against an epitope of the mouse MATE-1. Applications: WB. Free samples available. Control antigen included. Lyophilized. Global shipping at room temperature. Your top supplier for Multidrug and toxin extrusion protein research!
https://www.alomone.com/p/anti-mate1/ANT-131
MP Antenna 2.4GHz Micro Omni Antenna (08-ANT-0956-BL-G)MP Antenna 2.4GHz Micro Omni Antenna (08-ANT-0956-BL-G)
The 2.2-2.6GHz MP Micro Omni Antenna are the latest in Multi-Polarized technology providing superior patterning and continuous performance for... Learn More!
https://www.solidsignal.com/mp-antenna-2-4ghz-micro-omni-antenna-08-ant-0956-bl-g
291 F.3d 1 | LexRoll.com291 F.3d 1 | LexRoll.com
19. EPA argues that its bifurcated approach to determining appropriate BART controls is permissible because § 169A(g)(2) is unclear about how a state must analyze anticipated visibility improvement. See Chevron U.S.A., Inc. v. Natural Res. Def. Council, 467 U.S. 837, 842-43, 104 S.Ct. 2778, 2781-82, 81 L.Ed.2d 694 (1984). We cannot agree. The Haze Rules splitting of the statutory factors is consistent with neither the text nor the structure of the statute. See 42 U.S.C. § 7491(g)(2). All five § 169A(g)(2) factors inform the states inquiries into what BART controls are appropriate for particular sources. Although no weights were assigned, the factors were meant to be considered together by the states. The language of § 169A(g)(2) can be read in no other way. To treat one of the five statutory factors in such a dramatically different fashion distorts the judgment Congress directed the states to make for each BART-eligible source. This is most apparent with respect to the states duty to take ...
http://circuitcourts.lexroll.com/2016/08/10/291-f-3d-1/
Thermogenin - WikipediaThermogenin - Wikipedia
Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is an uncoupling protein found in the mitochondria of brown adipose tissue (BAT). It is used to generate heat by non-shivering thermogenesis, and makes a quantitatively important contribution to countering heat loss in neonates which would otherwise occur due to their high surface area-volume ratio. UCPs are transmembrane proteins that decrease the proton gradient generated in oxidative phosphorylation. They do this by increasing the permeability of the inner mitochondrial membrane, allowing protons that have been pumped into the intermembrane space to return to the mitochondrial matrix. UCP1-mediated heat generation in brown fat uncouples the respiratory chain, allowing for fast substrate oxidation with a low rate of ATP production. UCP1 is related to other mitochondrial metabolite transporters such as the adenine nucleotide translocator, a proton channel in the mitochondrial inner membrane ...
https://en.wikipedia.org/wiki/Thermogenin
Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cellsTargeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells
The HIV-1 encoded apoptogenic protein Vpr induces mitochondrial membrane permeabilization (MMP) via interactions with the voltage-dependent anion channel (VDAC) and the adenine nucleotide translocator (ANT). We have designed a peptide, TEAM-VP, composed of two functional domains, one a tumor blood v …
https://pubmed.ncbi.nlm.nih.gov/16888644/
AINTEGUMENTA and AINTEGUMENTA-LIKE6 Act Redundantly to Regulate Arabidopsis Floral Growth and Patterning | Plant PhysiologyAINTEGUMENTA and AINTEGUMENTA-LIKE6 Act Redundantly to Regulate Arabidopsis Floral Growth and Patterning | Plant Physiology
Figure 3. The expression patterns of AP3 and AG are altered in ant-4 ail6-2 flowers. A, RNA gel blot of AP3 mRNA in Ler, ant-4, ail6-2, and ant-4 ail6-2 inflorescences. Ethidium bromide staining of ribosomal RNA is shown below the gel blot. B, AP3 expression in stage 3 Ler flower. C and D, AP3 is expressed in fewer cells of stage 3 ant-4 ail6-2 flowers. E, AP3 expression in stage 10 Ler flower. F, AP3 mRNA was detected at the base of some floral organs in this ant-4 ail6-2 flower. G, RNA gel blot of AG mRNA in Ler, ant-4, ail6-2, and ant-4 ail6-2 inflorescences. Ethidium bromide staining of ribosomal RNA is shown below the gel blot. H, AG expression in stage 3 Ler flower. Arrows point to the outer boundary of AG expression. I and J, AG expression in stage 3 (I) and stage 4 (J) ant-4 ail6-2 flowers. Arrows point to the outer boundary of AG expression. AG mRNA is not detected in the very central cells of the floral meristem. K, AG expression in stage 7 Ler flower. L, AG expression is detected in ...
http://www.plantphysiol.org/content/150/4/1916/tab-figures-data
Modeling of ATP-ADP steady-state exchange rate mediated by the adenine nucleotide translocase in isolated mitochondria -...Modeling of ATP-ADP steady-state exchange rate mediated by the adenine nucleotide translocase in isolated mitochondria -...
A computational model for the ATP-ADP steady-state exchange rate mediated by adenine nucleotide translocase (ANT) versus mitochondrial membrane potential dependence in isolated rat liver mitochondria is presented. The model represents the system of three ordinary differential equations, and the basic components included are ANT,...
http://scipeople.ru/publication/67177/
The biology of mitochondrial uncoupling proteinsThe biology of mitochondrial uncoupling proteins
Uncoupling proteins (UCPs) are mitochondrial transporters present in the inner membrane of mitochondria. They are found in all mammals and in plants. They belong to the family of anion mitochondrial carriers including adenine nucleotide transporters. The term uncoupling protein was originally used …
https://pubmed.ncbi.nlm.nih.gov/14749278/
ANT1 - Peroxisomal adenine nucleotide transporter 1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) -...ANT1 - Peroxisomal adenine nucleotide transporter 1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) -...
Adenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen. This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol. Transport of ATP into the peroxisome is required for beta-oxidation of medium-chain fatty acids. Required for growth on medium-chain fatty acids, pH gradient formation in peroxisomes and for normal peroxisome proliferation.
http://www.uniprot.org/uniprot/Q06497
Acute Knockdown of Uncoupling Protein-2 Increases Uncoupling via the Adenine Nucleotide Transporter and Decreases Oxidative...Acute Knockdown of Uncoupling Protein-2 Increases Uncoupling via the Adenine Nucleotide Transporter and Decreases Oxidative...
Increased O(2) metabolism resulting in chronic hypoxia is common in models of endstage renal disease. Mitochondrial uncoupling increases O(2) consumption but the ensuing reduction in mitochondrial membrane potential may limit excessive oxidative stress. The present study addressed the hypothesis that mitochondrial uncoupling regulates mitochondria function and oxidative stress in the diabetic kidney. Isolated mitochondria from kidney cortex of control and streptozotocin-induced diabetic rats were studied before and after siRNA knockdown of uncoupling protein-2 (UCP-2). Diabetes resulted in increased UCP-2 protein expression and UCP-2-mediated uncoupling, but normal mitochondria membrane potential. This uncoupling was inhibited by GDP, which also increased the membrane potential. siRNA reduced UCP-2 protein expression in controls and diabetics (-30-50%), but paradoxically further increased uncoupling and markedly reduced the membrane potential. This siRNA mediated uncoupling was unaffected by GDP ...
http://www.diva-portal.org/smash/record.jsf?pid=diva2:540966
We have beforehand claimed that glutamate and the adenine nucleotide translocase inhibitor, carboxyatractyloside, ameliorate...
OXPHOS - Adenine Nucleotide Assays and Issues
OXPHOS - this site is dedicated to mitochondria research. Theoretical and practical aspects, reagents, protocols, tools, funding agencies, databases, conferences, etc.
http://oxphos.net/index.php?option=com_content&task=view&id=93&Itemid=1
Crow Calls - Next SaleCrow Calls - Next Sale
Crazy Crow Trading Post: Largest line of Native American craft supplies & kits anywhere. Beads, leather, feathers, blankets, books- over 8000 items online.
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Remodeling of the chromatin structure of the facioscapulohumeral muscular dystrophy (FSHD) locus and upregulation of FSHD...Remodeling of the chromatin structure of the facioscapulohumeral muscular dystrophy (FSHD) locus and upregulation of FSHD...
Background: Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant neuromuscular disorder associated with the partial deletion of integral numbers of 3.3 kb D4Z4 DNA repeats within the subtelomere of chromosome 4q. A number of candidate FSHD genes, adenine nucleotide translocator 1 gene (ANT1), FSHD-related gene 1 (FRG1), FRG2 and DUX4c, upstream of the D4Z4 array (FSHD locus), and double homeobox chromosome 4 (DUX4) within the repeat itself, are upregulated in some patients, thus suggesting an underlying perturbation of the chromatin structure. Furthermore, a mouse model overexpressing FRG1 has been generated, displaying skeletal muscle defects. Results: In the context of myogenic differentiation, we compared the chromatin structure and tridimensional interaction of the D4Z4 array and FRG1 gene promoter, and FRG1 expression, in control and FSHD cells. The FRG1 gene was prematurely expressed during FSHD myoblast differentiation, thus suggesting that the number of D4Z4 repeats in ...
https://epub.ub.uni-muenchen.de/23590/
Starvation-Survival Patterns of Sixteen Freshly Isolated Open-Ocean Bacteria | Applied and Environmental MicrobiologyStarvation-Survival Patterns of Sixteen Freshly Isolated Open-Ocean Bacteria | Applied and Environmental Microbiology
Sixteen marine isolates from a NORPAX cruise, which were transferred once on medium after initial isolation, survived nutrient deprivation for at least 8 months (longest period test). All but one isolate remained cellularly intact, although their sizes and shapes changed greatly, and all became smaller, decreasing in size from 40 to 79%. Three starvation-survival patterns were demonstrated, namely (i) an initial increase in viable cells followed by a decrease until a constant number was reached, (ii) an increase in viable cells until a constant number was reached, and (iii) a decrease in viable cells until a constant number was reached. One isolate from each starvation-survival pattern was starved for 8 months and then was tested in comparison with 4-month-starved Ant-300 for [14C]glutamic acid uptake, respiration, and incorporation. The response to glutamic acid was rapid and linear in each case. The data indicate that the starvation-survival of Ant-300 is not an anomalous situation and that ...
https://aem.asm.org/content/45/3/1109?ijkey=ea4b42a4b7d0e92dff518a5e90e3409184fca8db&keytype2=tf_ipsecsha
Adenine - Drugs.comAdenine - Drugs.com
Adenine is a medicine available in a number of countries worldwide. A list of US medications equivalent to Adenine is available on the Drugs.com website.
https://www.drugs.com/international/adenine.html
Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase<...
TY - JOUR. T1 - Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase. AU - Nadtochiy, Sergiy M.. AU - Zhu, Qiuyu. AU - Urciuoli, William. AU - Rafikov, Ruslan. AU - Black, Stephen M.. AU - Brookes, Paul S.. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2012/1/27. Y1 - 2012/1/27. N2 - Electrophilic nitrated lipids (nitroalkenes) are emerging as an important class of protective cardiovascular signaling molecules. Although species such as nitro-linoleate (LNO 2) and nitro-oleate can confer acute protection against cardiac ischemic injury, their mechanism of action is unclear. Mild uncoupling of mitochondria is known to be cardioprotective, and adenine nucleotide translocase 1 (ANT1) is a key mediator of mitochondrial uncoupling. ANT1 also contains redox-sensitive cysteines that may be targets for modification by nitroalkenes. Therefore, in this study we tested the hypothesis that nitroalkenes directly modify ANT1 and that nitroalkene-mediated ...
https://augusta.pure.elsevier.com/en/publications/nitroalkenes-confer-acute-cardioprotection-via-adenine-nucleotide
Vesicular nucleotide transporter (VNUT): appearance of an actress on the stage of purinergic signaling<...
TY - JOUR. T1 - Vesicular nucleotide transporter (VNUT). T2 - appearance of an actress on the stage of purinergic signaling. AU - Moriyama, Yoshinori. AU - Hiasa, Miki. AU - Sakamoto, Shohei. AU - Omote, Hiroshi. AU - Nomura, Masatoshi. PY - 2017/9/1. Y1 - 2017/9/1. N2 - Vesicular storage of ATP is one of the processes initiating purinergic chemical transmission. Although an active transport mechanism was postulated to be involved in the processes, a transporter(s) responsible for the vesicular storage of ATP remained unidentified for some time. In 2008, SLC17A9, the last identified member of the solute carrier 17 type I inorganic phosphate transporter family, was found to encode the vesicular nucleotide transporter (VNUT) that is responsible for the vesicular storage of ATP. VNUT transports various nucleotides in a membrane potential-dependent fashion and is expressed in the various ATP-secreting cells. Mice with knockout of the VNUT gene lose vesicular storage and release of ATP from neurons ...
https://kyushu-u.pure.elsevier.com/en/publications/vesicular-nucleotide-transporter-vnut-appearance-of-an-actress-on
Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2...Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2...
AIMS: In this study we investigated whether attenuation of endoplasmic reticulum stress (ER stress) could protect HepG2 cells from free fatty acid (FFA)-induced apoptosis. MAIN METHODS: Human liver cell line HepG2 cells were exposed to Sodium Palmitate (Pa) or Sodium Oleate (Ol). Apoptosis and ER stress of HepG2 cells were analyzed with flow cytometry, real-time RT-PCR and Western Blotting. An expression plasmid encoding for the ER chaperone immunoglobulin heavy chain-binding protein (Bip) was transfected into HepG2 cells to attenuate ER stress. Small interfering RNA siCHOP was used to knockdown the expression of C/EBP Homologous Protein (CHOP) in HepG2. KEY FINDINGS: Pa led to cytotoxicity and apoptosis in HepG2 cells in a dose-dependent pattern and also induced ER stress indicated by increased phosphorylation of eIF2alpha, upregulation of IRE1alpha and CHOP. Bip expression levels were slightly down regulated after Pa treatment. The unsaturated fatty acid, Ol, induced neither apoptosis nor ER stress in
https://www.garvan.org.au/research/publications/10884
Multiple Deletions in Logistic Regression Models | Korea ScienceMultiple Deletions in Logistic Regression Models | Korea Science
Multiple Deletions in Logistic Regression Models - Conditional deletions;logistic regression models;masking effects;multiple deletions;outliers;swamping effects;
http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=GCGHC8_2009_v16n2_309
Ad5-CMV-Ant2 | Seven Hills BioreagentsAd5-CMV-Ant2 | Seven Hills Bioreagents
Vector ConstructionMouse cDNA for the adenine nucleotide translocase 2 (inner mitochondrial membrane transporter). It was cloned into the multiple cloning site of pAC-CMV-pLpA. The resulting plasmid was cotransfected into HEK293 cells with plasmid pJM17 which contains the Ad5 genome. Homologous recombination between the two plasmids resulted in the replacement of the Ad5 early region 1 with the mouse cDNA for Ant2, generating a replication deficient recombinant virus. ...
https://www.sevenhillsbioreagents.com/products/ad5-cmv-ant2
Hepatic Adenine Nucleotides and DNA Synthesis during the Regenerative and Atrophic Process of the Liver Lobes after Selective...Hepatic Adenine Nucleotides and DNA Synthesis during the Regenerative and Atrophic Process of the Liver Lobes after Selective...
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http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART00001059
Fatty-acid-induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is...Fatty-acid-induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is...
Both cis and trans unsaturated fatty acids and sodium dodecyl sulfate activated NADPH oxidase in plasma membranes of human neutrophils in the presence of neutrophil cytosol. In contrast, 5,8,11,14-icosatetraynoic acid, saturated fatty acids, esters, peroxides and 4 beta-phorbol 12-myristate 13-acetate, a potent activator of protein kinase C, were inactive. 5,8,11,14-icosatetraynoic acid inhibited superoxide formation elicited by fatty acids. Guanosine 5[gamma-thio]triphosphate (GTP[gamma S]), a potent activator of guanine-nucleotide-binding proteins (N-proteins) enhanced superoxide formation elicited by fatty acids up to fourfold, supporting our previous suggestion that NADPH oxidase is regulated by an N-protein [Seifert, R. et al. (1986) FEBS Lett. 205, 161-165]. Cytosols from various tissues, soybean lipoxygenase and protein kinase C, purified from chicken stomach, did not substitute neutrophil cytosol. The activity of neutrophil cytosol was destroyed by heating at 95 degrees C. Superoxide ...
https://epub.uni-regensburg.de/23273/
Oxidative Phosphorylation Diseases | The Online Metabolic and Molecular Bases of Inherited Disease | OMMBID | McGraw-Hill...Oxidative Phosphorylation Diseases | The Online Metabolic and Molecular Bases of Inherited Disease | OMMBID | McGraw-Hill...
Oxidative phosphorylation (OXPHOS) is composed of five intramitochondrial enzyme complexes (complexes I to V) that are responsible for producing the majority of the ATP required for normal cellular function. Assembly and maintenance of OXPHOS requires the coordinate regulation of nuclear DNA and mitochondrial DNA (mtDNA) genes. The mtDNA encodes 12 OXPHOS subunits, 22 tRNAs, and 2 rRNAs, which provide the core elements for OXPHOS function and mitochondrial protein synthesis. The nuclear DNA is responsible for synthesizing approximately 70 OXPHOS subunits, transporting them to the mitochondria via chaperone proteins, ensuring their passage across the mitochondrial inner membrane, and coordinating their proper processing and assembly. OXPHOS is regulated by a wide variety of factors and processes that include hormone levels, oxygen supply, ion gradients, membrane transporters such as the adenine nucleotide translocase that supplies ADP for conversion to ATP, transcription factors that alter the ...
http://ommbid.mhmedical.com/content.aspx?bookid=971§ionid=62634554
Author: Suyama, Masaki / Subject: adenosine triphosphate - PubAg Search ResultsAuthor: Suyama, Masaki / Subject: adenosine triphosphate - PubAg Search Results
Bongkrekic acid (BKA) is a strong inhibitor of adenine nucleotide translocase (ANT), inducing inhibition of adenosine triphosphate synthesis. We designed and synthesized simplified benzene-ring-containing BKA analogs. The key reaction is the one-pot double Sonogashira reaction, which forms the main skeleton. The analogs were efficiently synthesized in 8-10 longest linear sequence steps. This synth ...
https://pubag.nal.usda.gov/?f%5Bsubject_term%5D%5B%5D=adenosine+triphosphate&q=%22Suyama%2C+Masaki%22&search_field=author
The effect of calcium on the translocation of adenine nucleotides in rat liver mitochondria. - Semantic ScholarThe effect of calcium on the translocation of adenine nucleotides in rat liver mitochondria. - Semantic Scholar
Semantic Scholar extracted view of The effect of calcium on the translocation of adenine nucleotides in rat liver mitochondria. by Armando Gómez-Puyou et al.
https://www.semanticscholar.org/paper/The-effect-of-calcium-on-the-translocation-of-aden-G%C3%B3mez-Puyou-G%C3%B3mez-Puyou/e29c56ebdeab09f6f095d1349f1988c39dcca0ce
TWINKLE TWINKLE PATRICK STAR Lyrics - SPONGEBOB SQUAREPANTS | eLyrics.netTWINKLE TWINKLE PATRICK STAR Lyrics - SPONGEBOB SQUAREPANTS | eLyrics.net
Spongebob Squarepants Twinkle Twinkle Patrick Star lyrics & video : Twinkle Twinkle Patrick Star And I made myself a sandwich My mommy named it Fred It tastes like beans and ba...
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Associated Effluxes of Calcium and Adenine Nucleotides from Mitochondria: Mediation by Thyroxine and other Agents, and...Associated Effluxes of Calcium and Adenine Nucleotides from Mitochondria: Mediation by Thyroxine and other Agents, and...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.biochemsoctrans.org/content/7/1/215
Its Me !!: Twinkle Totz Set Tupperware bayiIts Me !!: Twinkle Totz Set Tupperware bayi
nota :: selalu kalah kalau dalam membeli barangan bayi. Ni pun tengah menunggu 2 parcel lagi barangan bayi. Will show show later ...
http://fizyanz.blogspot.com/2013/04/twinkle-totz-set-tupperware-bayi.html
AS 25 2 217 218 Tanasevitch et alAS 25 2 217 218 Tanasevitch et al
Tanasevitch A.V.1, Ponomarev A.V.2, Chumachenko Yu.A.3 2016. A new species of Tenuiphantes Saaristo et Tanasevitch, 1996 (Aranei: Linyphiidae) from Adygea, the Caucasus, Russia // Arthropoda Selecta. Vol.25. No.2: 217-218 [in English].. 1 Institute of Ecology and Evolution, Russian Academy of Sciences, Leninsky prospekt, 33, Moscow 119071, Russia. E-mail: [email protected] 2 Institute of Arid Zones, Southern Scientific Centre, Russian Academy of Sciences, Chekhov str., 41, Rostov-on-Don 344006, Russia. E-mail: [email protected] 3 Caucasian State Biosphere Nature Reserve, Sovetskaya str., 187, Maykop 385000 Russia. E-mail: [email protected] KEY WORDS: Spiders, Micronetinae, Adygea, Lagonaki Plateau, the northern Caucasus, Russia, subalpine, new species.. ABSTRACT. Tenuiphantes lagonaki sp.n. (?) is described from the mountains of the northern Caucasus, Adygea. The new species is most similar to the Anatolian T. wunderlichi Saaristo et Tanasevitch, 1996, from which it readily ...
https://kmkjournals.com/journals/AS/AS_Index_Volumes/AS_25/AS_25_2_217_218_Tanasevitch_et_al
Glycerophosphoglycerophosphoglycerols (Cardiolipins) - Glycerophospholipids | Sigma-AldrichGlycerophosphoglycerophosphoglycerols (Cardiolipins) - Glycerophospholipids | Sigma-Aldrich
Cardiolipin is found predominantly in the membranes of mitochondria and bacteria. It is a unique diphosphatidylglycerol containing four acyl groups. In animal tissues 80% of the acyl groups are composed of linoleic acid (18:2(n-6)).The identification of Barth′s syndrome, a disease associated with abnormalities in the fatty acid composition of cardiolipin causing cardiomyopathy and neutropenia, has displayed the importance of cardiolipin in mitochondrial functionality. Cardiolipin effects mitochondrial bioenergetics by providing essential structural and functional support to proteins localized within the mitochondria. Specifically, interaction of cardiolipin with cytochrome oxidase and adenine nucleotide translocase is required in order for both of these mitochondrial enzymes to maintain activity.Cardiolipin has been shown to perform a role in a number of other specific biological activities, including oxidative phosphorylation, apoptosis, cholesterol translocation and gene
https://www.sigmaaldrich.com/life-science/biochemicals/biochemical-products.html?TablePage=15845151
Adenine nucleotides in snail muscles as one of biomarkers of fluoride toxicity - Journal of Environmental Monitoring (RSC...Adenine nucleotides in snail muscles as one of biomarkers of fluoride toxicity - Journal of Environmental Monitoring (RSC...
The aim of this work was to determine the extent of bioaccumulation of fluorides in tissues of Helix aspersa maxima. The toxicity of fluorides administered orally on the energy balance of the snails foot was investigated based on measurements of concentrations of adenine nucleotides and their metabolism deg
http://pubs.rsc.org/en/Content/ArticleLanding/EM/2005/B415833B
High-energy phosphates and related adenine nucleotides. | Open-iHigh-energy phosphates and related adenine nucleotides. | Open-i
High-energy phosphates and related adenine nucleotides.Metabolites were measured by HPLC in Control, SHF and DHF hearts. A-C. Chromatograms of extracts from ven
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4366225_pone.0118974.g003&req=4
HIV-1 p24 Antibody | Anti HIV1 p24 Monoclonal | ProSpecHIV-1 p24 Antibody | Anti HIV1 p24 Monoclonal | ProSpec
Mouse Monoclonal antibodies against HIV-1 full length recombinant p24. Captures the p24 antigen. May be paired with mAbs catalog numbers ant-748.
https://www.prospecbio.com/hiv1_p24_antibody
Twinkle Twinkle Little Star - interactive songs | Apps | 148AppsTwinkle Twinkle Little Star - interactive songs | Apps | 148Apps
~~ 9 educational activities & games inside + a full interactive Twinkle Twinkle song ~~ ~~ More than 2,000,000 downloads, Selected New and Noteworthy by...
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A man ninety years old was asked to what he attributed his longevity. I reckon, he said, with a twinkle in his eye, it because...A man ninety years old was asked to what he attributed his longevity. I reckon, he said, with a twinkle in his eye, it because...
A man ninety years old was asked to what he attributed his longevity. I reckon, he said, with a twinkle in his eye, it because most nights I went to bed and slept when I should have sat up and worried. - Garson Kanin quotes from BrainyQuote.com
https://www.brainyquote.com/quotes/garson_kanin_119545
Adenine nucleotide translocatorAdenine nucleotide translocator
Adenine+Nucleotide+Translocator+2 at the US National Library of Medicine Medical Subject Headings (MeSH) Adenine+Nucleotide+ ... Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or ... Adenine+Nucleotide+Translocator+1 at the US National Library of Medicine Medical Subject Headings (MeSH) ... Pressman BC (June 1958). "Intramitochondrial nucleotides. I. Some factors affecting net interconversions of adenine nucleotides ...
https://en.wikipedia.org/wiki/Adenine_nucleotide_translocator
Bcl-2-associated X proteinBcl-2-associated X protein
"Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science. 281 (5385): 2027-31. ... In addition, it can become activated by binding BCL-2, as well as non-BCL-2 proteins such as p53 and Bif-1. Conversely, BAX can ... Weng C, Li Y, Xu D, Shi Y, Tang H (March 2005). "Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related ... 307 (1): 70-5. doi:10.1016/S0003-2697(02)00028-3. PMID 12137781. Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, ...
https://en.wikipedia.org/wiki/Bcl-2-associated_X_protein
BCL2L13BCL2L13
Kim JY, So KJ, Lee S, Park JH (Sep 2012). "Bcl-rambo induces apoptosis via interaction with the adenine nucleotide translocator ... Bcl-rambo mediates apoptosis by associating with adenine nucleotide translocator (ANT), a component of the mitochondrial ... 34 (1): 18-23. doi:10.1016/j.leukres.2009.07.023. PMID 20109966. Jensen SA, Calvert AE, Volpert G, Kouri FM, Hurley LA, Luciano ... 534 (1-3): 61-8. doi:10.1016/S0014-5793(02)03778-X. PMID 12527362. S2CID 7018829. Human BCL2L13 genome location and BCL2L13 ...
https://en.wikipedia.org/wiki/BCL2L13
Sengers syndromeSengers syndrome
AGK gene encodes the mitochondrial acylglycerol kinase which plays a role in the assembly of adenine nucleotide translocator. ... There are two forms of the disease: 1. The lethal neonatal form. Hypertrophic cardiomyopathy is diagnosed at birth in half. ... The SLC25A4 gene encodes the heart and muscle-specific isoform 1 of the mitochondrial adenine nucleotide translocator. The ...
https://en.wikipedia.org/wiki/Sengers_syndrome
CYC1CYC1
"Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR ... Nishikimi M, Ohta S, Suzuki H, Tanaka T, Kikkawa F, Tanaka M, Kagawa Y, Ozawa T (April 1988). "Nucleotide sequence of a cDNA ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Valnot I, Kassis J, Chretien D, de Lonlay P, Parfait B, ... 19 (2): 400-1. doi:10.1006/geno.1994.1084. PMID 8188279. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S ( ...
https://en.wikipedia.org/wiki/CYC1
AGK (gene)AGK (gene)
AGK also has an implicated role in the assembly of the adenine nucleotide translocator in the inner mitochondrial membrane. ... 108 (1): 40-50. doi:10.1016/j.ymgme.2012.11.282. PMID 23266196. Nouh MA, Wu XX, Okazoe H, Tsunemori H, Haba R, Abou-Zeid AM, ... ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate. The enzyme is involved in the more general pathway of ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano ...
https://en.wikipedia.org/wiki/AGK_(gene)
List of MeSH codes (D12.776)List of MeSH codes (D12.776)
... adenine nucleotide translocator 2 MeSH D12.776.575.750.500.300 - adenine nucleotide translocator 3 MeSH D12.776.580.210.175.325 ... adenine nucleotide translocator 1 MeSH D12.776.575.750.500.200 - ... neuregulin-1 See List of MeSH codes (D12.776.476). MeSH D12.776 ... cofilin 1 MeSH D12.776.220.525.212.750 - cofilin 2 MeSH D12.776.220.525.212.875 - destrin MeSH D12.776.220.525.246.500 - actin- ... hiv-1 reverse transcriptase MeSH D12.776.964.970.880.325 - gene products, env MeSH D12.776.964.970.880.325.330 - hiv envelope ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
ANT1 (disambiguation)ANT1 (disambiguation)
... adenine nucleotide translocator 1) is the most abundant protein in the inner mitochondrial membrane. It is an enzyme that in ...
https://en.wikipedia.org/wiki/ANT1_(disambiguation)
List of MeSH codes (D12.776.157)List of MeSH codes (D12.776.157)
... adenine nucleotide translocator 2 MeSH D12.776.157.530.625.875.500.300 - adenine nucleotide translocator 3 MeSH D12.776.157.530 ... adenine nucleotide translocator 1 MeSH D12.776.157.530.625.875.500.200 - ... nucleotide transport proteins MeSH D12.776.157.530.625.875.500 - mitochondrial adp, atp translocases MeSH D12.776.157.530. ... aryl hydrocarbon receptor nuclear translocator MeSH D12.776.157.530.750.200 - cellular apoptosis susceptibility protein MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.157)
Y linkageY linkage
... adenine nucleotide translocator-3 on the Y), AZF2 (azoospermia factor 2), BPY2 (basic protein on the Y chromosome), AZF1 ( ... family 1, member A1), RBM2 (RNA binding motif protein 2), and UTY (ubiquitously transcribed TPR gene on Y chromosome). USP9Y ... azoospermia factor 1), DAZ (Spermatogenes is deleted in azoospermia), RBM1 (RNA binding motif protein, Y chromosome, ...
https://en.wikipedia.org/wiki/Y_linkage
List of MeSH codes (D12.776.543)List of MeSH codes (D12.776.543)
... adenine nucleotide translocator 2 MeSH D12.776.543.585.450.162.235.300 - adenine nucleotide translocator 3 MeSH D12.776.543.585 ... adenine nucleotide translocator 2 MeSH D12.776.543.585.625.875.500.300 - adenine nucleotide translocator 3 MeSH D12.776.543.585 ... adenine nucleotide translocator 1 MeSH D12.776.543.585.450.162.235.200 - ... adenine nucleotide translocator 1 MeSH D12.776.543.585.625.875.500.200 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.543)
ARHGAP11BARHGAP11B
... where it binds to the adenine nucleotide translocator. It does not affect the adenine nucleotide exchange activity of the ... A 2016 study suggests, one mutation, a "single nucleotide substitution underlies the specific properties of ARHGAP11B that ... translocator, but it does lead to delayed opening of the mitochondrial permeability transition pore, thus allowing for greater ... In contrast to full-length ARHGAP11A and ARHGAP11A 1-250, ARHGAP11B, like ARHGAP11A1-220, did not exhibit RhoGAP activity in a ...
https://en.wikipedia.org/wiki/ARHGAP11B
ApoptosomeApoptosome
... the inner membrane protein adenine nucleotide translocator (AdNT) and the matrix protein cyclophilin D (CyD) (12). This pore ... It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. ... A short linker and nucleotide binding a/b domains (NBD) that contain conserved Walker boxes A (p-loop 155-161) and B (239-243) ... a central nucleotide-binding and oligomerization region (NB-ARC/NOD, 128-586) and a C-terminal WD40 region (613-1248) making up ...
https://en.wikipedia.org/wiki/Apoptosome
MT-TTMT-TT
... myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator". ... MT-TT is a small 66 nucleotide RNA (human mitochondrial map position 15888-15953) that transfers the amino acid threonine to a ... 225 (1): 180-5. doi:10.1006/bbrc.1996.1150. PMID 8769114. This article incorporates text from the United States National ...
https://en.wikipedia.org/wiki/MT-TT
ThermogeninThermogenin
UCP1 is very similar to the ATP/ADP Carrier protein, or Adenine Nucleotide Translocator (ANT). The proposed alternating access ... UCP1 is related to other mitochondrial metabolite transporters such as the adenine nucleotide translocator, a proton channel in ... UCP1 is activated in the brown fat cell by fatty acids and inhibited by nucleotides. Fatty acids are released by the following ... overriding the inhibition caused by purine nucleotides (GDP and ADP). During the termination of thermogenesis, thermogenin is ...
https://en.wikipedia.org/wiki/Thermogenin
TXN2TXN2
... thiols in the mitochondrial permeability transition pore component adenine nucleotide translocator (ANT). Overexpression of ... "Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer". Cancer Research. ... 465 (1): 119-26. doi:10.1016/j.abb.2007.05.001. PMID 17548047. Oestergaard MZ, Tyrer J, Cebrian A, Shah M, Dunning AM, Ponder ... Zhou J, Damdimopoulos AE, Spyrou G, Brüne B (Mar 2007). "Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on ...
https://en.wikipedia.org/wiki/TXN2
Ant (disambiguation)Ant (disambiguation)
Actor-network theory, an approach to social theory and research Adenine nucleotide translocator Anacamptis (abbreviation Ant), ... ISO 3166-1 alpha-3 country code) River Ant, a river in Norfolk, England Ant (name), English language nickname abbreviated from ...
https://en.wikipedia.org/wiki/Ant_(disambiguation)
Substrate-level phosphorylationSubstrate-level phosphorylation
... but also to prevent mitochondria from straining glycolytic ATP reserves by maintaining the adenine nucleotide translocator in ' ... "Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level ... "Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues". The Journal of ... 1,3-bisphosphoglycerate is then dephosphorylated via phosphoglycerate kinase, producing 3-phosphoglycerate and ATP through a ...
https://en.wikipedia.org/wiki/Substrate-level_phosphorylation
MitochondrionMitochondrion
ROS increases uncoupling proteins (UCPs) and potentiate proton leakage through the adenine nucleotide translocator (ANT), the ... One of the two mitochondrial DNA (mtDNA) strands has a disproportionately higher ratio of the heavier nucleotides adenine and ... Nachman MW, Crowell SL (September 2000). "Estimate of the mutation rate per nucleotide in humans". Genetics. 156 (1): 297-304. ... Tumor cells require ample ATP to synthesize bioactive compounds such as lipids, proteins, and nucleotides for rapid ...
https://en.wikipedia.org/wiki/Mitochondrion
Membrane transport proteinMembrane transport protein
Adenine nucleotide translocator (ANT) 2.B: Nonribosomally synthesized porters, such as: The Nigericin family The Ionomycin ... such as rhodopsin The group translocators provide a special mechanism for the phosphorylation of sugars as they are transported ... ISBN 1-4292-1962-9. p. 119. Cooper, Geoffrey (2009). The Cell: A Molecular Approach. Washington, DC: ASM Press. p. 62. ISBN ... ISBN 1-4292-1962-9. p. 119. Ashley, Ruth. Hann, Gary. Han, Seong S. Cell Biology. New Age International Publishers. ISBN ...
https://en.wikipedia.org/wiki/Membrane_transport_protein
Jerzy Duszyński (biochemist)Jerzy Duszyński (biochemist)
1982). "Quantification of the role of the adenine nucleotide translocator in the control of mitochondrial respiration in ... The first quantification of the controlling weight of adenine nucleotide transport in cellular bioenergetics. Quantification of ... 1 year, including in Grenoble). The course of his scientific career has been closely linked to the Nencki Institute of ...
https://en.wikipedia.org/wiki/Jerzy_Duszyński_(biochemist)
Mitochondrial carrierMitochondrial carrier
SLC25A25 adenine nucleotide - SLC25A4, SLC25A5, SLC25A6, SLC25A31 dicarboxylate - SLC25A10 oxoglutarate - SLC25A11 glutamate - ... "Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential". Journal ... Mitochondrial carriers transport amino acids, keto acids, nucleotides, inorganic ions and co-factors through the mitochondrial ... nucleotides, amino acids, keto acids and cofactors across the membrane. Such proteins include: ADP/ATP carrier protein (ADP-ATP ...
https://en.wikipedia.org/wiki/Mitochondrial_carrier
Mitochondrial permeability transition poreMitochondrial permeability transition pore
Further hypothesis by Halestrap's group convincingly suggested the MPT was formed by the inner membrane Adenine Nucleotide ... "The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore". Nature. 427 (6973): 461-465. doi ... "The nature of the calcium ion efflux induced in rat liver mitochondria by the oxidation of endogenous nicotinamide nucleotides ... "Regulation of the Inner Membrane Mitochondrial Permeability Transition by the Outer Membrane Translocator Protein (Peripheral ...
https://en.wikipedia.org/wiki/Mitochondrial_permeability_transition_pore
Identification of an Epitope from Adenine Nucleotide Translocator 1 that Induces Inflammation in Heart in A/J MiceIdentification of an Epitope from Adenine Nucleotide Translocator 1 that Induces Inflammation in Heart in A/J Mice
Role of an adenine-nucleotide translocator in regulation of mitochondrial pyruvate oxidation in the heart. Bulletin of ... Inhibition of the adenine nucleotide translocator by matrix-localized palmityl-CoA in rat heart mitochondria. Biochimica et ... Participation of the adenine nucleotide translocator in the regulation of pyruvate oxidation in heart mitochondria. Biulleten& ... The role of adenine nucleotide translocator in the regulation of oxidative phosphorylation in heart mitochondria. Biokhimiia 53 ...
https://eurekamag.com/research/058/038/058038534.php
SLC25A4 gene: MedlinePlus GeneticsSLC25A4 gene: MedlinePlus Genetics
The SLC25A4 gene provides the instructions for making a protein called adenine nucleotide translocase type 1 (ANT1). Learn ... Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup. Proc ... Complete loss-of-function of the heart/muscle-specific adenine nucleotide translocator is associated with mitochondrial ... The adenine nucleotide translocase type 1 (ANT1): a new factor in mitochondrial disease. IUBMB Life. 2005 Sep;57(9):607-14. doi ...
https://medlineplus.gov/genetics/gene/slc25a4/
Association of novel POLG mutations and multiple mitochondrial DNA deletions with variable clinical phenotypes in a Spanish...Association of novel POLG mutations and multiple mitochondrial DNA deletions with variable clinical phenotypes in a Spanish...
The uncommon phenotype found in 1 of these patients stresses the clinical variability of patients harboring POLG mutations. ... Adenine Nucleotide Translocator 1 * DNA, Mitochondrial * Mitochondrial Proteins * DNA Primase * DNA Polymerase gamma ... 2006 Jan;63(1):107-11. doi: 10.1001/archneur.63.1.107. Authors Emiliano González-Vioque 1 , Alberto Blázquez, Daniel Fernández- ... 1 Departamento de Bioquímica, Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, Universidad Autónoma de Madrid, ...
https://pubmed.ncbi.nlm.nih.gov/16401742/
IJMS | Free Full-Text | Genes and Pathways Involved in Adult Onset Disorders Featuring Muscle Mitochondrial DNA InstabilityIJMS | Free Full-Text | Genes and Pathways Involved in Adult Onset Disorders Featuring Muscle Mitochondrial DNA Instability
Adenine nucleotide translocator. AD. Adult. dels. muscle. PEO. TYMP. 22q13. Thymidine phosphorylase. AR. Late childhood ... Role of adenine nucleotide translocator 1 in mtDNA maintenaince. Science 2000, 289, 782-785. [Google Scholar] [CrossRef] [ ... Adenine nucleotide translocator 1 deficiency associated with Sengers syndrome. Ann. Neurol. 2002, 52, 95-99. [Google Scholar] [ ... Dörner, A.; Schultheiss, H.P. Adenine nucleotide translocase in the focus of cardiovascular diseases. Trends Cardiovasc. Med. ...
https://www.mdpi.com/1422-0067/16/8/18054/htm
Facioscapulohumeral Dystrophy: Background, Pathophysiology, EpidemiologyFacioscapulohumeral Dystrophy: Background, Pathophysiology, Epidemiology
Increased levels of adenine nucleotide translocator 1 protein and response to oxidative stress are early events in ... Misexpression of FRG1 (FSHD region gene 1) may lead to the development of FSHD. Knockdown of FRG1 in Xenopus led to the ... FSHD is considered one of the more common hereditary muscular disorders with a prevalence of ~1 in 8,000. It appears to affect ... FSHD region gene 1 (FRG1) is crucuial for angiogenesis linkinh FRG! to facioscapulohumeral muscular dystrophy-associated ...
https://www.medscape.com/answers/1176126-189661/what-is-the-prevalence-of-facioscapulohumeral-dystrophy-fshd
Science Clips - Volume 9, Issue 22, June 6, 2017Science Clips - Volume 9, Issue 22, June 6, 2017
20 and adenine nucleotide translocator (ANT) 1/2/3/4 that regulate mitochondrial permeability. The results suggest that an ... The isolates were 20 and 26 nucleotide divergent from prototype Sabin strain (with 18 identical mutations) consistent with ... and Candida lusitaniae Targeting rDNA region nucleotide sequences, primers specific for C. auris only or C. auris and related ... Compared to 1-/13-year-olds, a larger percentage of 16-/17-year-olds had parents who discussed their shift to adult care (aPR ...
https://www.cdc.gov/library/sciclips/issues/v9issue22.html
NIOSHTIC-2 Search Results - Full View
... membrane and in normal operation of other mitochondrial multicomponent machines such as adenine nucleotide translocator, as ... 1 (versus cyt c). Similarly, MCL- and DCL-stimulated peroxidase activity of cyt c could be eliminated by a large excess (versus ... 1) Bid and tBid have a high-affinity binding domain for a mitochondria specific phospholipid, cardiolipin (CL).(2-5) In normal ... 1) an electron shuttle between respiratory complexes III and IV and (2) a scavenger of superoxide anion radicals.(13) Recently ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=genetic&f1=TI&Startyear=&t1=1&s2=genetic&terms=3&Adv=1&ct=&B1=Search&f2=KW&Limit=500&Sort=DP+DESC&D1=10&EndYear=&PageNo=39&RecNo=389&View=f&
MH DELETED MN ADDED MNMH DELETED MN ADDED MN
Adenine Nucleotide Translocator 2 D12.776.157.530.937.594.200 D12.776.543.585.937.688.200 Adenine Nucleotide Translocator 3 ... Adenine D3.438.759.138 D3.633.100.759.138 Adenine Nucleotide Translocator 1 D12.776.157.530.937.594.100 D12.776.543.585.937.688 ... Adenine Nucleotides D3.438.759.646.138 D3.633.100.759.646.138 Adenosine D3.438.759.590.138 D3.633.100.759.590.138 Adenosine ... Cyclic Nucleotide 3-Phosphodiesterase D12.776.641.580.124 D12.776.631.580.124 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- ...
https://decs.bvs.br/E/mnchg2017.txt
Viruses as Modulators of Mitochondrial FunctionsViruses as Modulators of Mitochondrial Functions
Viruses like Herpes simplex virus 1 deplete the host mitochondrial DNA and some, like human immunodeficiency virus, hijack the ... H. L. A. Vieira, A. S. Belzacq, D. Haouzi et al., "The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite ... "Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat ... A. S. Belzacq, H. L. A. Vieira, F. Verrier et al., "Bcl-2 and Bax modulate adenine nucleotide translocase activity," Cancer ...
https://www.hindawi.com/journals/av/2013/738794/
Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity<...
... adenine nucleotide translocator, and ATP synthase] associate with SDH. A purified IM fraction containing these proteins was ... adenine nucleotide translocator, and ATP synthase] associate with SDH. A purified IM fraction containing these proteins was ... adenine nucleotide translocator, and ATP synthase] associate with SDH. A purified IM fraction containing these proteins was ... adenine nucleotide translocator, and ATP synthase] associate with SDH. A purified IM fraction containing these proteins was ...
https://jhu.pure.elsevier.com/en/publications/multiprotein-complex-containing-succinate-dehydrogenase-confers-m-3
SustainPineDB
Sma3: Adenine nucleotide translocator 4.049e-24 Complete sp_v3.0_unigene2178 SustainPine v3.0 2079 • AutoFact: Grave disease ... putative mitochondrial phosphate translocator protein [Arabidopsis thaliana] gb,AEC06606.1, phosphate transporter 3;3 [ ... AutoFact: Mitochondrial dicarboxylate carrier protein, putative n=1 Tax=Ricinus communis RepID=B9SXH6_RICCO 6.0e-39 ... AutoFact: ADP,ATP carrier protein, putative n=1 Tax=Ricinus communis RepID=B9RVW7_RICCO 0.0 ...
https://www.scbi.uma.es/sustainpinedb/annotations/28?ann_id=185333&tab=ung
Search Redox biology as journal on MyScienceWorks publications...Search Redox biology as journal on MyScienceWork's publications...
Adenine nucleotide translocator 1 (ANT1), the only 4q35 gene involved in mitochondrial function, is strongly expressed in FSHD ... hypoxia-inducible factor-1α (HIF-1α), AMP-activated protein kinase (AMPK), and ... ...
https://www.mysciencework.com/publication/facets/journal/Redox%2520biology
DeCSDeCS
Adenine Nucleotide Carrier Protein Adenine Nucleotide Translocator, Muscle Isoform SLC25A4 Protein Solute Carrier Family 25 ( ... Adenine Nucleotide Carrier Protein. Adenine Nucleotide Translocator, Muscle Isoform. SLC25A4 Protein. Solute Carrier Family 25 ... Adenine Nucleotide Translocator 1 - Preferred Concept UI. M0000349. Scope note. A subtype of mitochondrial ADP, ATP translocase ... Adenine Nucleotide Translocator 1 Entry term(s). ANT 1 Transport Protein ANT-1 Transport Protein ANT1 Transport Protein ...
https://decs.bvsalud.org/en/ths/resource/?id=37400
Immune Cell Apoptosis Prevention as Potential Therapy for Severe Infections - Volume 13, Number 2-February 2007 - Emerging...
Weaver JG, Tarze A, Moffat TC, Lebras M, Deniaud A, Brenner C, Inhibition of adenine nucleotide translocator pore function and ... Figure 1. Figure 1. Apoptotic pathways of cell death. The extrinsic pathway is mediated by a variety of death receptor ligands ... The authors of 1 report argued that the beneficial effect of Bcl-2 did not depend on prevention of lymphocyte apoptosis because ... Table 1. Distinguishing features of apoptosis and necrosis * Table 2. Antiapoptotic therapeutic approaches for prevention of ...
https://wwwnc.cdc.gov/eid/article/13/2/06-0963_article
Kallikrein 3/PSA Antibody (KLK3/801) (NBP2-44886): Novus BiologicalsKallikrein 3/PSA Antibody (KLK3/801) (NBP2-44886): Novus Biologicals
Adenine Nucleotide. Translocator 2 Antibo ... NBP2-92630. Species: Hu, Mu, Rt. Applications: ICC/IF, IHC, IHC-P, WB ... Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating ... It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). A higher proportion ... It is predominantly complexed to a liverderived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). A higher proportion ...
https://www.novusbio.com/products/kallikrein-3-psa-antibody-klk3-801_nbp2-44886
IMP: Integrative Multi-species Prediction
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5. 0.016. ... Tax1 (human T-cell leukemia virus type I) binding protein 1. 0.028. ...
http://imp.princeton.edu/predictions/process_ortho/human-context-global/8950/
研究成果を検索 - Keio University
A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed ... Hirata, M., Hashimoto, Y., Noguchi, S. & Adachi, S., 2010 2月, In: Mechatronics. 20, 1, p. 59-66 8 p.. 研究成果: Article › 査読 ... Oi, S., Saya, H. & Matsumoto, S., 1988 1月 1, In: Journal of neurosurgery. 68, 6, p. 947-954 8 p.. 研究成果: Article › 査読 ... Kanda, T., Kamasima, M., Imai, M., Ono, T., Sakamoto, D., Ishiguro, H. & Anzai, Y., 2007 1月, In: Autonomous Robots. 22, 1, p. ...
https://keio.pure.elsevier.com/ja/publications/?indexableKeyword=%2Fdk%2Fatira%2Fpure%2Fsustainabledevelopmentgoals%2Faffordable_and_clean_energy&format=&page=1584&ordering=title&descending=true
SustainPineDB
Adenine nucleotide translocator; Short=ANT gb,AAA33027.1, ATP/ADP translocator [Parachlorella kessleri] 4.0e-32 ... AutoFact: Adenine nucleotide translocator (Fragment) n=1 Tax=Angiostrongylus cantonensis RepID=F5GTH3_9BILA 9.0e-29 ... AutoFact: Glyceraldehyde-3-phosphate dehydrogenase, type I n=1 Tax=Bacteroides coprosuis DSM 18011 RepID=F3ZU50_9BACE 5.0e-24 ... AutoFact: Caffeoyl-CoA O-methyltransferase n=1 Tax=Chamaecyparis obtusa var. formosana RepID=A0S6W3_CHAOB 0.0 ...
https://www.scbi.uma.es/sustainpinedb/annotations/28?ann_id=189871&page=6&tab=ung
尋找研究成果 - 臺北醫學大學
Antimicrobial peptide TP4 targets mitochondrial adenine nucleotide translocator 2. Su, B. C., Liu, Y. C., Ting, C. H., Lyu, P. ... Burnouf, T., Chou, M. L., Wu, Y. W., Su, C. Y. & Lee, L. W., 1月 2013, 於: Transfusion. 53, 1, p. 138-146 9 p.. 研究成果: 雜誌貢獻 › 文章 ... Zhang, J., Li, R. K., Chen, K. H., Ge, L. & Tian, J. H., 1月 2016, 於: BMJ Open. 6, 1, e010264.. 研究成果: 雜誌貢獻 › 文章 › 同行評審 ... Wu, C. J., Sheu, J. R., Chen, H. H., Shyur, S. D., Chen, P. G. & Chen, Y. J., 2003, 於: Neoplasma. 50, 1, p. 54-59 6 p..
https://tmu.pure.elsevier.com/zh/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&publicationYear=2017&publicationYear=2018&format=&nofollow=true&ordering=title&descending=false&page=62
KEGG ORTHOLOGY: K05863
K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. 04022 cGMP-PKG ... K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. 09160 Human ... K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. 05020 Prion ... K05863 SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. 09180 Brite ...
https://www.genome.jp/dbget-bin/www_bget?ko:K05863
Antiandrogen-induced cell death in LNCaP human prostate cancer cells | Cell Death & DifferentiationAntiandrogen-induced cell death in LNCaP human prostate cancer cells | Cell Death & Differentiation
... been shown to increase its cytotoxicity and has been implicated in facilitating the assemble of adenine nucleotide translocator ... Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator ... Figure 1. Effects of TNF-α and Casodex on cell adhesiveness, mitochondrial dehydrogenase activities and mitochondrial membrane ... Cytosolic extracts of WT LNCaP cells (1 × 106 cells) treated with control vehicle, 10 ng/ml TNF-α or 100 μM Casodex for 48 h in ...
https://www.nature.com/articles/4401228?error=cookies_not_supported&code=c5cc6052-6155-4537-9885-21591a64cbf4
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 Adenine Nucleotide Translocator 3 ... D9.408.477.410 Kangai-1 Protein D12.776.395.550.465 D12.776.395.550.16 D12.776.543.550.462 D12.776.543.550.182 D12.776.624.776. ... E5.200.812.735.50.450 LDL-Receptor Related Protein 1 D23.50.301.264.35.502 D23.101.100.110.498 (Replaced for 2012 by Low ... D12.776.92.500.925 Voltage-Dependent Anion Channel 1 D12.776.543.585.475.750 D12.776.575.750.750 Voltage-Dependent Anion ...
https://decs2017.bvsalud.org/E/mnchg2012.txt
MH DELETED MN ADDED MN
Adenine Nucleotide Translocator 2 D12.776.157.530.937.594.200 D12.776.543.585.937.688.200 Adenine Nucleotide Translocator 3 ... Adenine D3.438.759.138 D3.633.100.759.138 Adenine Nucleotide Translocator 1 D12.776.157.530.937.594.100 D12.776.543.585.937.688 ... Adenine Nucleotides D3.438.759.646.138 D3.633.100.759.646.138 Adenosine D3.438.759.590.138 D3.633.100.759.590.138 Adenosine ... Cyclic Nucleotide 3-Phosphodiesterase D12.776.641.580.124 D12.776.631.580.124 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- ...
https://decs2018.bvsalud.org/E/mnchg2017.txt
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 Adenine Nucleotide Translocator 3 ... D9.408.477.410 Kangai-1 Protein D12.776.395.550.465 D12.776.395.550.16 D12.776.543.550.462 D12.776.543.550.182 D12.776.624.776. ... E5.200.812.735.50.450 LDL-Receptor Related Protein 1 D23.50.301.264.35.502 D23.101.100.110.498 (Replaced for 2012 by Low ... D12.776.92.500.925 Voltage-Dependent Anion Channel 1 D12.776.543.585.475.750 D12.776.575.750.750 Voltage-Dependent Anion ...
https://decs2015.bvsalud.org/E/mnchg2012.txt
MH DELETED MN ADDED MN
Adenine Nucleotide Translocator 2 D12.776.157.530.937.594.200 D12.776.543.585.937.688.200 Adenine Nucleotide Translocator 3 ... Adenine D3.438.759.138 D3.633.100.759.138 Adenine Nucleotide Translocator 1 D12.776.157.530.937.594.100 D12.776.543.585.937.688 ... Adenine Nucleotides D3.438.759.646.138 D3.633.100.759.646.138 Adenosine D3.438.759.590.138 D3.633.100.759.590.138 Adenosine ... Cyclic Nucleotide 3-Phosphodiesterase D12.776.641.580.124 D12.776.631.580.124 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3- ...
https://decs2019.bvsalud.org/P/mnchg2017.txt
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 Adenine Nucleotide Translocator 3 ... D9.408.477.410 Kangai-1 Protein D12.776.395.550.465 D12.776.395.550.16 D12.776.543.550.462 D12.776.543.550.182 D12.776.624.776. ... E5.200.812.735.50.450 LDL-Receptor Related Protein 1 D23.50.301.264.35.502 D23.101.100.110.498 (Replaced for 2012 by Low ... D12.776.92.500.925 Voltage-Dependent Anion Channel 1 D12.776.543.585.475.750 D12.776.575.750.750 Voltage-Dependent Anion ...
https://decs2013.bvsalud.org/P/mnchg2012.txt
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 Adenine Nucleotide Translocator 3 ... D9.408.477.410 Kangai-1 Protein D12.776.395.550.465 D12.776.395.550.16 D12.776.543.550.462 D12.776.543.550.182 D12.776.624.776. ... E5.200.812.735.50.450 LDL-Receptor Related Protein 1 D23.50.301.264.35.502 D23.101.100.110.498 (Replaced for 2012 by Low ... D12.776.92.500.925 Voltage-Dependent Anion Channel 1 D12.776.543.585.475.750 D12.776.575.750.750 Voltage-Dependent Anion ...
https://decs2014.bvsalud.org/I/mnchg2012.txt
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 Adenine Nucleotide Translocator 3 ... D9.408.477.410 Kangai-1 Protein D12.776.395.550.465 D12.776.395.550.16 D12.776.543.550.462 D12.776.543.550.182 D12.776.624.776. ... E5.200.812.735.50.450 LDL-Receptor Related Protein 1 D23.50.301.264.35.502 D23.101.100.110.498 (Replaced for 2012 by Low ... D12.776.92.500.925 Voltage-Dependent Anion Channel 1 D12.776.543.585.475.750 D12.776.575.750.750 Voltage-Dependent Anion ...
https://decs2020.bvsalud.org/E/mnchg2012.txt
MESH TREE NUMBER CHANGES - 2012 MeSH. August 19, 2011
D12.776.543.585.475.500.100 Adenine Nucleotide Translocator 2 D12.776.543.585.475.500.200 Adenine Nucleotide Translocator 3 ... D9.408.477.410 Kangai-1 Protein D12.776.395.550.465 D12.776.395.550.16 D12.776.543.550.462 D12.776.543.550.182 D12.776.624.776. ... E5.200.812.735.50.450 LDL-Receptor Related Protein 1 D23.50.301.264.35.502 D23.101.100.110.498 (Replaced for 2012 by Low ... D12.776.92.500.925 Voltage-Dependent Anion Channel 1 D12.776.543.585.475.750 D12.776.575.750.750 Voltage-Dependent Anion ...
https://decs2016.bvsalud.org/E/mnchg2012.txt
ANT1Mitochondrial ProteinsPhosphateFragmentPhosphoribosyltransferaseGeneCarrierPeptideSubunitPutativeMitochondriaHomologMemberApoptosisPrimary AntibodiesTermLysineMethyltransferaseCullinReceptorSerineHUMANTranscriptionFoundStructuresSourceCancerExpressionCellPatientsComplex
ANT13
  • In support of this notion, intracellular cardiac antigens, like cardiac myosin heavy chain-α, cardiac troponin-I, and adenine nucleotide translocator 1 (ANT1), have been identified as autoantigens in cardiac autoimmunity. (eurekamag.com)
  • The SLC25A4 gene provides the instructions for making a protein called adenine nucleotide translocase type 1 (ANT1). (medlineplus.gov)
  • Adenine nucleotide translocator 1 (ANT1), the only 4q35 gene involved in mitochondrial function, is strongly expressed in FSHD skeletal muscle biopsies. (mysciencework.com)
Mitochondrial Proteins4
  • Viruses like Herpes simplex virus 1 deplete the host mitochondrial DNA and some, like human immunodeficiency virus, hijack the host mitochondrial proteins to function fully inside the host cell. (hindawi.com)
  • Although the majority of the mitochondrial proteins are encoded by nuclear DNA and imported into the mitochondria (reviewed by [ 21 , 28 - 31 ]), mitochondria synthesize few proteins that are essential for their respiratory function [ 1 , 27 ]. (hindawi.com)
  • Four mitochondrial proteins [mitochondrial ATP-binding cassette protein 1 (mABC1), phosphate carrier, adenine nucleotide translocator, and ATP synthase] associate with SDH. (elsevier.com)
  • 2013). Additionally, decreases in cellular PA may also destabilize the assembly of the adenine nucleotide translocators (ANTs), a subset of highly abundant mitochondrial proteins essential for ADP/ATP translocation across the mitochondrial inner membrane (Mayr et al. (preventiongenetics.com)
Phosphate2
  • It plays a very important role in the assembly and maintenance of functionally active respiratory complexes (I, III and IV and F0/F1-ATPase) in the mitochondrial membrane and in normal operation of other mitochondrial multicomponent machines such as adenine nucleotide translocator, as well as tricarboxylate, pyruvate and phosphate carriers. (cdc.gov)
  • undecaprenyl pyrophosphate:lipid A 1-phosphate phosphotransferase [Ensembl]. (ntu.edu.sg)
Fragment1
  • the shortened Eco RI fragment in FSHD is 1-10 units. (medscape.com)
Phosphoribosyltransferase1
Gene1
  • Misexpression of FRG1 (FSHD region gene 1) may lead to the development of FSHD. (medscape.com)
Carrier1
  • The 18 kDa translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is a hetero-oligomeric complex comprising the voltage-dependent anion channel as well as an adenine nucleotide carrier found in both the periphery and the brain [ 1 - 4 ]. (biomedcentral.com)
Peptide1
  • The 824 amino acid precursor of human ADAM8 consists of a signal peptide (residues 1 to 16), a pro peptide (residues 17 to 199), a metaloprotease domain (residues 200 to 400), a disintegrin-like domain (residues 408 to 494), a cysteine-rich region (residues 497 to 613), an EGF-like domain (residues 614 to 640), a transmembrane region (residues 656 to 676) and a cytoplasmic domain (residues 677 to 824). (novusbio.com)
Subunit1
Putative1
  • XV" YOL105C 1 15 18 YOL105C "Putative integral membrane protein containing novel cysteine motif. (davidson.edu)
Mitochondria7
  • 1) Bid and tBid have a high-affinity binding domain for a mitochondria specific phospholipid, cardiolipin (CL). (cdc.gov)
  • 4,12) Cyt c is an important contributor to redox reactions in the intermembrane space of mitochondria where it functions as (1) an electron shuttle between respiratory complexes III and IV and (2) a scavenger of superoxide anion radicals. (cdc.gov)
  • 1) Electron microscope studies have shown abnormalities in the mitochondria of cancer cells. (greenmedinfo.com)
  • All of the Group B patients were found have sub-normal TL IN values (ie, they have reduced translocator protein transfer of ATP from mitochondria to the cytosol of the cell). (phoenixrising.me)
  • And 78% of the Group B patients have sub-normal values of TL OUT (decreased translocator protein ferrying of ADP from the cell to the mitochondria). (phoenixrising.me)
  • Does TL refer to the translocator protein transfer of ATP from mitochondria to the cytosol of the cell? (phoenixrising.me)
  • The translocator protein (TL) has two functions and is a two-way street: it carries fresh ATP from the mitochondria into the rest of the cell (this Myhill calls TL IN), and also carries the spent ATP (it becomes ADP once spent) back out from the cell into the mitochondria for recycling (TL OUT). (phoenixrising.me)
Homolog1
Member2
  • ADAM8, also known as cell surface antigen MS2 or CD156a, is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain (1, 2). (novusbio.com)
  • GTPase, IMAP family member 1 [Source:H. (gsea-msigdb.org)
Apoptosis1
  • 1 Casodex, an antiandrogen used in prostate cancer therapy, is designed to reduce tumor size by interfering with normal androgen receptor (AR)-mediated processes that ensure prostate cell survival and by triggering tumor cells to undergo apoptosis. (nature.com)
Primary Antibodies1
  • Primary Antibodies are guaranteed for 1 year from date of receipt. (novusbio.com)
Term1
  • Note that Myhill et al use the term 'translocator protein' to refer to the adenine nucleotide translocator (ANT). (phoenixrising.me)
Lysine1
Methyltransferase2
  • Caffeoyl-CoA O-methyltransferase n=1 Tax=Chamaecyparis obtusa var. (uma.es)
  • tRNA (Guanine-1)-methyltransferase [Interproscan]. (ntu.edu.sg)
Cullin1
Receptor1
  • RESULTS: GDNF-RET signaling formed a positive feedback loop with EGR1 and also downregulated estrogen receptor 1 (ESR1) transcription. (bvsalud.org)
Serine1
  • It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). (novusbio.com)
HUMAN3
  • In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse ADAM8 is observed and less than 1% cross-reactivity with recombinant human (rh) ADAM12, rhADAM19, and rhADAM33 is observed. (novusbio.com)
  • We studied the distribution and expression of translocator protein in the human brain using 11 C-[R]-PK-11195 positron emission tomography (PK11195 PET) and evaluated age-related changes. (biomedcentral.com)
  • Description: RAB5C Human Recombinant produced in E. coli is a single polypeptide chain containing 239 amino acids (1-216) and having a molecular mass of 25.9kDa. (hiv-pharmacogenomics.org)
Transcription1
  • We recently reported that glial cell-derived neurotrophic factor (GDNF)-RET signaling appears to promote a positive feedback loop with the transcription factor early growth response 1 (EGR1). (bvsalud.org)
Found1
  • The uncommon phenotype found in 1 of these patients stresses the clinical variability of patients harboring POLG mutations. (nih.gov)
Structures1
  • The brain shows low PK11195 uptake, which is lower in the cortex and cerebellum compared with subcortical structures, suggesting a low level of translocator protein expression. (biomedcentral.com)
Source4
  • In growing plants, sucrose is the most widespread sugar used to supply both carbon and energy from 'source' tissues (e.g. autotrophic mesophyll) to 'sink' tissues (e.g. heterotrophic roots, growing shoots or reproductive organs) to build up a biomass [ 1 ]. (biomedcentral.com)
  • angiopoietin like 1 [Source:HGNC Symbo. (gsea-msigdb.org)
  • debranching RNA lariats 1 [Source:HGNC. (gsea-msigdb.org)
  • extracellular matrix protein 1 [Source. (gsea-msigdb.org)
Cancer1
  • 1) Dr. Seyfried says: "cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. (greenmedinfo.com)
Expression2
  • This increase in uptake suggests an age-related increase in translocator protein expression or the number of cells expressing these receptors or both. (biomedcentral.com)
  • Additionally, we show that rGDNF treatment activated GDNF-RET signaling in TamS cells, leading to recruitment of phospho-ELK-1 to the EGR1 promoter, upregulation of EGR1 mRNA and protein, binding of EGR1 to the GDNF and CCND1 promoters, increased GDNF protein expression, and subsequent upregulation of CCND1 mRNA levels. (bvsalud.org)
Cell2
  • This process is an apparent acceleration or dysregulation of the same process by which these cell populations are regulated during normal health ( 1 , 2 ). (cdc.gov)
  • Giant cell arteritis (GCA) is a granulomatous disease that displays tissue tropism for large and medium arteries manifesting as aortitis and vasculitis of the second to fifth branches of the aorta [ 1 ]. (biomedcentral.com)
Patients2
  • Five patients with PEO had mutations: 2 were compound heterozygotes, 1 was homozygous, and another showed a mutation in a single allele. (nih.gov)
  • Those without FSHD have approximately 11-100 D4Z4 units, whereas patients with FSHD have 1-10 D4Z4 units. (medscape.com)
Complex2
  • tBid almost completely inhibited the peroxidase activity of CL/cyt c complex only at ratios exceeding 20 : 1 (versus cyt c). (cdc.gov)
  • Many download Encountering Nature only regulates epithelium place from -ATPase and may be a differential planned weight in features Ligand-binding unique fertility, not its multiple-nucleotide initiates recognized directly although the addition of ARG2 under citric complex infections promotes limited. (erik-mill.de)
SLC25A4 gene: MedlinePlus Genetics
SLC25A4 gene: MedlinePlus Genetics (medlineplus.gov)
Facioscapulohumeral Dystrophy: Background, Pathophysiology, Epidemiology
Facioscapulohumeral Dystrophy: Background, Pathophysiology, Epidemiology (medscape.com)
Progressive external ophthalmoplegia: MedlinePlus Genetics
Progressive external ophthalmoplegia: MedlinePlus Genetics (medlineplus.gov)
Viruses as Modulators of Mitochondrial Functions
Viruses as Modulators of Mitochondrial Functions (hindawi.com)
SustainPineDB
SustainPineDB (scbi.uma.es)
Search Redox biology as journal on MyScienceWork's publications...
Search Redox biology as journal on MyScienceWork's publications... (mysciencework.com)
Immune Cell Apoptosis Prevention as Potential Therapy for Severe Infections - Volume 13, Number 2-February 2007 - Emerging...
Immune Cell Apoptosis Prevention as Potential Therapy for Severe Infections - Volume 13, Number 2-February 2007 - Emerging... (wwwnc.cdc.gov)
研究成果を検索 - Keio University
研究成果を検索 - Keio University (keio.pure.elsevier.com)
John Lemasters | Profiles RNS
John Lemasters | Profiles RNS (profiles.musc.edu)
MitoPedia - Bioblast
MitoPedia - Bioblast (mitofit.org)
Metabolic model of central carbon and energy metabolisms of growing Arabidopsis thaliana in relation to sucrose translocation |...
Metabolic model of central carbon and energy metabolisms of growing Arabidopsis thaliana in relation to sucrose translocation |... (bmcplantbiol.biomedcentral.com)
Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of...
Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of... (elifesciences.org)
Evaluation of age-related changes in translocator protein (TSPO) in human brain using 11C-[R]-PK11195 PET | Journal of...
Evaluation of age-related changes in translocator protein (TSPO) in human brain using 11C-[R]-PK11195 PET | Journal of... (jneuroinflammation.biomedcentral.com)
Giant cell arteritis: immune and vascular aging as disease risk factors | Arthritis Research & Therapy | Full Text
Giant cell arteritis: immune and vascular aging as disease risk factors | Arthritis Research & Therapy | Full Text (arthritis-research.biomedcentral.com)
Cancer as a Curable Metabolic Disease | GreenMedInfo | Blog Entry
Cancer as a Curable Metabolic Disease | GreenMedInfo | Blog Entry (greenmedinfo.com)
Slc25a13 ELISA Kits
Slc25a13 ELISA Kits (antibodies-online.cn)
60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH in: Journal of Molecular Endocrinology Volume 56 Issue 4 (2016)
60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH in: Journal of Molecular Endocrinology Volume 56 Issue 4 (2016) (jme.bioscientifica.com)
Human RAB5C(RAB5C, Member RAS Oncogene Family) ELISA Kit - Hiv Pharmacogenomics
Human RAB5C(RAB5C, Member RAS Oncogene Family) ELISA Kit - Hiv Pharmacogenomics (hiv-pharmacogenomics.org)
Dna ancestry - Scalegenomics
Dna ancestry - Scalegenomics (scalegen.com)
COVID-19 Vaccine Alters Biochemical Composition of Glial Cells
COVID-19 Vaccine Alters Biochemical Composition of Glial Cells (medscape.com)
POLG-Related Disorders - GeneReviews® - NCBI Bookshelf
POLG-Related Disorders - GeneReviews® - NCBI Bookshelf (ncbi.nlm.nih.gov)
Facioscapulohumeral Dystrophy Treatment & Management: Medical Care, Surgical Care
Facioscapulohumeral Dystrophy Treatment & Management: Medical Care, Surgical Care (medscape.com)