Adenine Nucleotide Translocator 1: A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM) and skeletal muscle (MUSCLE, SKELETAL).Mitochondrial ADP, ATP Translocases: A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. They facilitate the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartments of ATP production to those of ATP utilization.Adenine Nucleotide Translocator 2: A subtype of mitochondrial ADP, ATP translocase found primarily in FIBROBLASTS.Atractyloside: A glycoside of a kaurene type diterpene that is found in some plants including Atractylis gummifera (ATRACTYLIS); COFFEE; XANTHIUM, and CALLILEPIS. Toxicity is due to inhibition of ADENINE NUCLEOTIDE TRANSLOCASE.Bongkrekic Acid: An antibiotic produced by Pseudomonas cocovenenans. It is an inhibitor of MITOCHONDRIAL ADP, ATP TRANSLOCASES. Specifically, it blocks adenine nucleotide efflux from mitochondria by enhancing membrane binding.Adenine NucleotidesAdenine Nucleotide Translocator 3: A subtype of mitochondrial ADP, ATP translocase found primarily in the LIVER.Oxidative Phosphorylation: Electron transfer through the cytochrome system liberating free energy which is transformed into high-energy phosphate bonds.Mitochondria: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)Mitochondria, Liver: Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)Nucleotidyltransferases: A class of enzymes that transfers nucleotidyl residues. EC 2.7.7.Intracellular Membranes: Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Voltage-Dependent Anion Channels: A family of voltage-gated eukaryotic porins that form aqueous channels. They play an essential role in mitochondrial CELL MEMBRANE PERMEABILITY, are often regulated by BCL-2 PROTO-ONCOGENE PROTEINS, and have been implicated in APOPTOSIS.Mitochondrial Membrane Transport Proteins: Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.Mitochondrial Swelling: An increase in MITOCHONDRIAL VOLUME due to an influx of fluid; it occurs in hypotonic solutions due to osmotic pressure and in isotonic solutions as a result of altered permeability of the membranes of respiring mitochondria.Mitochondria, Heart: The mitochondria of the myocardium.Adenine: A purine base and a fundamental unit of ADENINE NUCLEOTIDES.Oxygen Consumption: The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)Cyclophilins: A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE SYSTEM. EC 5.2.1.-Membrane Potential, Mitochondrial: The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.Uncoupling Agents: Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.Cell Respiration: The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell.Permeability: Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.Aryl Hydrocarbon Receptor Nuclear Translocator: Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with DIOXIN RECEPTOR. The complex binds xenobiotic regulatory elements and activates transcription of a variety of genes including UDP GLUCURONOSYLTRANSFERASE. AhR nuclear translocator is also a subunit of HYPOXIA-INDUCIBLE FACTOR 1.Proto-Oncogene Proteins c-bcl-2: Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.Mitochondrial Proteins: Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.Nucleotides: The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Kinetics: The rate dynamics in chemical or physical systems.DNA, Mitochondrial: Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Receptors, GABA: Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen.Receptors, Aryl Hydrocarbon: Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.Energy Metabolism: The chemical reactions involved in the production and utilization of various forms of energy in cells.Purine Nucleotides: Purines attached to a RIBOSE and a phosphate that can polymerize to form DNA and RNA.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Guanine NucleotidesAdenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Hypoxanthines: Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism.
(1/69) Induction of an unregulated channel by mutations in adenine nucleotide translocase suggests an explanation for human ophthalmoplegia.

Adenine nucleotide translocase (Ant) is primarily involved in ATP/ADP exchange across the mitochondrial inner membrane. Recently, the A114P missense mutation in the human Ant1 protein was found to be associated with autosomal dominant progressive external ophthalmoplegia (adPEO). Ant1(A114P) was proposed to cause an imbalance of the mitochondrial deoxynucleotide pool that subsequently affects the accuracy of mtDNA replication, thereby leading to accumulation of mutant mtDNA. In the present study, it has been shown that the A128P mutation of the Saccharomyces cerevisiae Aac2 protein, equivalent to A114P in human Ant1p, does not always affect respiratory growth. However, expression of aac2(A128P) results in depolarization, structural swelling and disintegration of mitochondria, and ultimately an arrest of cell growth in a dominant-negative manner. The aac2(A128P) mutation likely induces an unregulated channel allowing free passage of solutes across the inner membrane. These data raise the possibility that the formation of an unregulated channel, rather than a defect in ATP/ADP exchange, is a direct pathogenic factor in human adPEO. The accumulation of mtDNA mutations might be a consequence of mitochondrial dysfunction.  (+info)

(2/69) Skeletal muscle mitochondrial free-fatty-acid content and membrane potential sensitivity in different thyroid states: involvement of uncoupling protein-3 and adenine nucleotide translocase.

The effect of triiodothyronine (T3) on mitochondrial efficiency could be related to an increase in the concentrations of some proteins, such as uncoupling proteins (UCPs). Free fatty acids (FFA) seem to be a cofactor essential for the uncoupling activity of UCP3. In this paper, we report that the hypothyroidism-hyperthyroidism transition is accompanied by increases: (i) in the endogenous levels of mitochondrial FFA and (ii) in the sensitivity to FFA shown by the mitochondrial respiration rate and membrane potential, which correlated with the level of UCP3 protein. The level of the mRNA for adenine-nucleotide translocase-1 (ANT) was not affected by the thyroid state, while the ANT contribution to FFA-induced changes in mitochondrial uncoupling was low in the hypothyroid and euthyroid states but became more relevant in the hyperthyroid state at the highest concentration of FFA.  (+info)

(3/69) Hypothermia preserves myocardial function and mitochondrial protein gene expression during hypoxia.

Hypothermia before and/or during no-flow ischemia promotes cardiac functional recovery and maintains mRNA expression for stress proteins and mitochondrial membrane proteins (MMP) during reperfusion. Adaptation and protection may occur through cold-induced change in anaerobic metabolism. Accordingly, the principal objective of this study was to test the hypothesis that hypothermia preserves myocardial function during hypoxia and reoxygenation. Hypoxic conditions in these experiments were created by reducing O2 concentration in perfusate, thereby maintaining or elevating coronary flow (CF). Isolated Langendorff-perfused rabbit hearts were subjected to perfusate (Po2 = 38 mmHg) with glucose (11.5 mM) and perfusion pressure (90 mmHg). The control (C) group was at 37 degrees C for 30 min before and 45 min during hypoxia, whereas the hypothermia (H) group was at 29.5 degrees C for 30 min before and 45 min during hypoxia. Reoxygenation occurred at 37 degrees C for 45 min for both groups. CF increased during hypoxia. The H group markedly improved functional recovery during reoxygenation, including left ventricular developed pressure (DP), the product of DP and heart rate, dP/dtmax, and O2 consumption (MVo2) (P < 0.05 vs. control). MVo2 decreased during hypothermia. Lactate and CO2 gradients across the coronary bed were the same in C and H groups during hypoxia, implying similar anaerobic metabolic rates. Hypothermia preserved MMP betaF1-ATPase mRNA levels but did not alter adenine nucleotide translocator-1 or heat shock protein-70 mRNA levels. In conclusion, hypothermia preserves cardiac function after hypoxia in the hypoxic high-CF model. Thus hypothermic protection does not occur exclusively through cold-induced alterations in anaerobic metabolism.  (+info)

(4/69) Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling.

Identification of factors regulating cardiomyocyte survival and growth is important to understand the pathogenesis of congenital heart diseases. Little is known about the molecular mechanism of cardiac functions triggered by serotonin. The link between signaling circuitry of external stimuli and the mitochondrial apoptotic machinery is of wide interest in cardiac diseases. Using cultured cardiomyocytes and 5-hydroxytryptamine (5-HT)2B-receptor knockout mice as an animal model of dilated cardiomyopathy, for the first time we show that serotonin via the Gq-coupled 5-HT2B-receptor protect cardiomyocytes against serum deprivation-induced apoptosis as manifested by DNA fragmentation, nuclear chromatin condensation, and TUNEL labeling. Serotonin prevents cytochrome c release and caspase-9 and -3 activation after serum deprivation via cross-talks between phosphatidylinositol-3 kinase/Akt and extracellular signal-regulated kinase (ERK) 1/2 signaling pathways. Serotonin binding to 5-HT2B-receptor activates ERK kinases to inhibit Bax expression induced by serum deprivation. Serotonin via phosphatidylinositol-3 kinase/Akt can activate NF-kappaB that is required for the regulation of the mitochondrial adenine nucleotide translocator (ANT-1). Parallel to these observations, ultrastructural analysis in the 5-HT2B-receptor knockout mice heart revealed pronounced mitochondrial defects in addition to altered mitochondrial enzyme activities (cytochrome oxidase and succinate dehydrogenase) and ANT-1 and Bax expressions. These findings identify 5-HT as a novel survival factor targeting mitochondria in cardiomyocytes.  (+info)

(5/69) A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells.

Mitochondria are the powerhouse of the cell and their disruption leads to cell death. We have used a peptide trivalent arsenical, 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO), to inactivate the adenine nucleotide translocator (ANT) that exchanges matrix ATP for cytosolic ADP across the inner mitochondrial membrane and is the key component of the mitochondrial permeability transition pore (MPTP). GSAO triggered Ca(2+)-dependent MPTP opening by crosslinking Cys(160) and Cys(257) of ANT. GSAO treatment caused a concentration-dependent increase in superoxide levels, ATP depletion, mitochondrial depolarization, and apoptosis in proliferating, but not growth-quiescent, endothelial cells. Endothelial cell proliferation drives new blood vessel formation, or angiogenesis. GSAO inhibited angiogenesis in the chick chorioallantoic membrane and in solid tumors in mice. Consequently, GSAO inhibited tumor growth in mice with no apparent toxicity at efficacious doses.  (+info)

(6/69) Increased adenine nucleotide translocator 1 in reactive astrocytes facilitates glutamate transport.

A hallmark of central nervous system (CNS) pathology is reactive astrocyte production of the chronic glial scar that is inhibitory to neuronal regeneration. The reactive astrocyte response is complex; these cells also produce neurotrophic factors and are responsible for removal of extracellular glutamate, the excitatory neurotransmitter that rises to neurotoxic levels in injury and disease. To identify genes expressed by reactive astrocytes, we employed an in vivo model of the glial scar and differential display PCR and found an increase in the level of Ant1, a mitochondrial ATP/ADP exchanger that facilitates the flux of ATP out of the mitochondria. Ant1 expression in reactive astrocytes is regulated by transforming growth factor-beta1, a pluripotent CNS injury-induced cytokine. The significance of increased Ant1 is evident from the observation that glutamate uptake is significantly decreased in astrocytes from Ant1 null mutant mice while a specific Ant inhibitor reduces glutamate uptake in wild-type astrocytes. Thus, the astrocytic response to CNS injury includes an apparent increase in energy mobilization capacity by Ant1 that contributes to neuroprotective, energy-dependent glutamate uptake.  (+info)

(7/69) Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity.

Mitochondrial permeability transition (MPT) has been proposed to play a key role in cell death. Downstream MPT events include the release of apoptogenic factors that sets in motion the mitochondrial apoptosome leading to caspase activation. The current work examined the regulation of MPT by membrane fluidity modulated upon cholesterol enrichment. Mitochondria enriched in cholesterol displayed increased microviscosity resulting in impaired MPT induced by atractyloside, a c-conformation stabilizing ligand of the adenine nucleotide translocator (ANT). This effect was dependent on the dose of cholesterol loaded and reversed upon the fluidization of mitochondria by the fatty acid derivative A2C. Mitoplasts derived from cholesterol-enriched mitochondria responded to atractyloside in a similar fashion as intact mitochondria, indicating that a significant amount of cholesterol is still found in the inner membrane. The effects of cholesterol on MPT induced by atractyloside were mirrored by the release of intermembrane proteins, cytochrome c, Smac/Diablo, and apoptosis inducing factor. However, cholesterol loading did not affect the uptake rate of adenine nucleotide hence dissociating the function of ANT as a MPT-mediated protein from its adenine nucleotide exchange function. Thus, these findings indicate that the ability of atractyloside to induce MPT via ANT requires an appropriate membrane fluidity range.  (+info)

(8/69) Protein components of mitochondrial DNA nucleoids in higher eukaryotes.

Mitochondrial DNA (mtDNA) is not packaged in nucleosomal particles, but has been reported to associate with the mitochondrial inner membrane. Gentle lysis of Xenopus oocyte mitochondria with nonionic detergent liberates a nucleoprotein complex containing mtDNA associated with a previously characterized DNA binding partner, mitochondrial transcription factor A (mtTFA), as well as a series of inner membrane proteins identified by sequencing. More extensive detergent treatment stripped most of these proteins from the DNA, leaving a limited number of proteins in a nucleoid core. Sequencing of the major proteins retained in association with mtDNA revealed the expected mtDNA binding proteins, mtTFA and mitochondrial single-stranded DNA binding protein (mtSSB), as well as four proteins not previously reported to associate with mtDNA. These include adenine nucleotide translocator 1, the lipoyl-containing E2 subunits of pyruvate dehydrogenase and branched chain alpha-ketoacid dehydrogenase and prohibitin 2. The association of several of these proteins with mtTFA-containing mtDNA nucleoids was confirmed by immunoprecipitation.  (+info)

*  Adenine nucleotide translocator
... 2 at the US National Library of Medicine Medical Subject Headings (MeSH) Adenine Nucleotide ... Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocator, exports ATP from the mitochondrial matrix and ... Adenine Nucleotide Translocator 1 at the US National Library of Medicine Medical Subject Headings (MeSH) ... "Role of adenine nucleotide translocator 1 in mtDNA maintenance". Science. 289 (5480): 782-785. doi:10.1126/science.289.5480.782 ...
*  ADP/ATP translocase
"Role of Adenine Nucleotide Translocator 1 in mtDNA Maintenance". Science. 289 (5480): 782-785. doi:10.1126/science.289.5480.782 ... Pressman BC (June 1958). "Intramitochondrial nucleotides. I. Some factors affecting net interconversions of adenine nucleotides ... Bruni A, Luciani S, Contessa AR (March 1964). "Inhibition by atractyloside of the binding of adenine-nucleotides to rat-liver ... In 1955, Siekevitz and Potter demonstrated that adenine nucleotides were distributed in cells in two pools located in the ...
*  SLC25A6
Jang JY, Lee CE (2003). "Mitochondrial adenine nucleotide translocator 3 is regulated by IL-4 and IFN-gamma via STAT-dependent ... Adenine nucleotide translocator Solute carrier family GRCh38: Ensembl release 89: ENSG00000169100 - Ensembl, May 2017 "Human ... 2001). "A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family". Neurology. 57 (12): 2295-8. ... 2002). "A novel D104G mutation in the adenine nucleotide translocator 1 gene in autosomal dominant progressive external ...
*  CYC1
2001). "Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral ... 1988). "Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1". Nucleic Acids Res. 16 (8): 3577. doi: ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Duncan AM, Ozawa T, Suzuki H, Rozen R (1994). "Assignment of ... 2002). "HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells". J. Biol. Chem. 277 ( ...
*  List of MeSH codes (D12.776)
... adenine nucleotide translocator 2 MeSH D12.776.575.750.500.300 - adenine nucleotide translocator 3 MeSH D12.776.580.210.175.325 ... adenine nucleotide translocator 1 MeSH D12.776.575.750.500.200 - ... cofilin 1 MeSH D12.776.220.525.212.750 - cofilin 2 MeSH D12.776 ... hiv-1 reverse transcriptase MeSH D12.776.964.970.880.325 - gene products, env MeSH D12.776.964.970.880.325.330 - hiv envelope ... neurofibromin 1 MeSH D12.776.402.150.500.500 - p120 gtpase activating protein MeSH D12.776.402.300.700.500 - ras-GRF1 MeSH ...
*  List of MeSH codes (D12.776.157)
... adenine nucleotide translocator 2 MeSH D12.776.157.530.625.875.500.300 -- adenine nucleotide translocator 3 MeSH D12.776. ... adenine nucleotide translocator 1 MeSH D12.776.157.530.625.875.500.200 -- ... nucleotide transport proteins MeSH D12.776.157.530.625.875.500 -- mitochondrial adp, atp translocases MeSH D12.776.157.530. ... 157.530.750.100 -- aryl hydrocarbon receptor nuclear translocator MeSH D12.776.157.530.750.200 -- cellular apoptosis ...
*  List of MeSH codes (D12.776.543)
... adenine nucleotide translocator 2 MeSH D12.776.543.585.450.162.235.300 -- adenine nucleotide translocator 3 MeSH D12.776. ... adenine nucleotide translocator 2 MeSH D12.776.543.585.625.875.500.300 -- adenine nucleotide translocator 3 MeSH D12.776. ... adenine nucleotide translocator 1 MeSH D12.776.543.585.450.162.235.200 -- ... adenine nucleotide translocator 1 MeSH D12.776.543.585.625.875.500.200 -- ...
*  SLC25A4
"Entrez Gene: SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4". Marzo I, ... "Deficiency of the adenine nucleotide translocator in muscle of a patient with myopathy and lactic acidosis: a new mitochondrial ... "A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed ... impact of the adenine nucleotide translocator". Cell Death and Differentiation. 7 (12): 1146-54. doi:10.1038/sj.cdd.4400778. ...
*  SLC25A31
"Entrez Gene: SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31". Gallerne C ... "Computational analysis of the transcriptional regulation of the adenine nucleotide translocator isoform 4 gene and its role in ... "The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells". The International ... Chevrollier A, Loiseau D, Reynier P, Stepien G (Jun 2011). "Adenine nucleotide translocase 2 is a key mitochondrial protein in ...
*  AGK (gene)
AGK also has an implicated role in the assembly of the adenine nucleotide translocator in the inner mitochondrial membrane. ... 108 (1): 40-50. doi:10.1016/j.ymgme.2012.11.282. PMID 23266196. Nouh MA, Wu XX, Okazoe H, Tsunemori H, Haba R, Abou-Zeid AM, ... ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate. The enzyme is involved in the more general pathway of ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano ...
*  Y linkage
... adenine nucleotide translocator-3 on the Y), SOX21 (known to cause baldness), AZF2 (azoospermia factor 2), BPY2 (basic protein ... family 1, member A1), RBM2 (RNA binding motif protein 2), and UTY (ubiquitously transcribed TPR gene on Y chromosome). USP9Y ... on the Y chromosome), AZF1 (azoospermia factor 1), DAZ (Spermatogenes is deleted in azoospermia), RBM1 (RNA binding motif ...
*  BCL2L13
Kim JY, So KJ, Lee S, Park JH (Sep 2012). "Bcl-rambo induces apoptosis via interaction with the adenine nucleotide translocator ... Bcl-rambo mediates apoptosis by associating with adenine nucleotide translocator (ANT), a component of the mitochondrial ... 34 (1): 18-23. doi:10.1016/j.leukres.2009.07.023. PMID 20109966. Jensen SA, Calvert AE, Volpert G, Kouri FM, Hurley LA, Luciano ... 534 (1-3): 61-8. doi:10.1016/S0014-5793(02)03778-X. PMID 12527362. Human BCL2L13 genome location and BCL2L13 gene details page ...
*  Bcl-2-associated X protein
"Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science. 281 (5385): 2027-31. ... 2 (1): 1-6. doi:10.1038/71316. PMID 10620799. Zhang H, Nimmer P, Rosenberg SH, Ng SC, Joseph M (2002). "Development of a high- ... In addition, it can become activated by binding BCL-2, as well as non-BCL-2 proteins such as p53 and Bif-1. Conversely, BAX can ... permanent dead link] Weng C, Li Y, Xu D, Shi Y, Tang H (March 2005). "Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis ...
*  SLC25A5
Ku DH, Kagan J, Chen ST, Chang CD, Baserga R, Wurzel J (Sep 1990). "The human fibroblast adenine nucleotide translocator gene. ... The product of this gene, adenine nucleotide translocator 2 (ANT2), functions as a major constituent of the mitochondrial ... Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 is a protein that in humans is ... adenine nucleotide translocator), member 5". Retrieved 2013-09-18. Chevrollier A, Loiseau D, Reynier P, Stepien G (Jun 2011). " ...
*  Boris Kholodenko
"The role of adenine nucleotide translocator in regulation of oxidative phosphorylation in heart mitochondria". FEBS Letters. ... "Calcium indirectly increases the control exerted by the adenine nucleotide translocator over 2-oxoglutarate oxidation in rat ... 368: 1-4. doi:10.1016/0014-5793(95)00562-n. Kholodenko, B.N.; Cascante, M.; Molenaar, D.; Demin, O.V.; Gugten van der, A.A.; ... 1: 141-150. Kholodenko, B.N.; Lyubarev, A.E.; Kurganov, B.I. (1992). "Control of the metabolic flux in the system with high ...
*  Apoptosome
... the inner membrane protein adenine nucleotide translocator (AdNT) and the matrix protein cyclophilin D (CyD) (12). This pore ... It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. ... A short linker and nucleotide binding a/b domains (NBD) that contain conserved Walker boxes A (p-loop 155-161) and B (239-243) ... a central nucleotide-binding and oligomerization region (NB-ARC/NOD, 128-586) and a C-terminal WD40 region (613-1248) making up ...
*  Thermogenin
UCP1 is related to other mitochondrial metabolite transporters such as the adenine nucleotide translocator, a proton channel in ... UCP1 is activated in the brown fat cell by fatty acids and inhibited by nucleotides. Fatty acids cause the following signaling ... overriding the inhibition caused by purine nucleotides (GDP and ADP). During the termination of thermogenesis, thermogenin is ... Uncoupling protein 1 was discovered in 1978 and was first cloned in 1988. Uncoupling protein two (UCP2), a homolog of UCP1, was ...
*  TXN2
... thiols in the mitochondrial permeability transition pore component adenine nucleotide translocator (ANT). Overexpression of ... "Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer". Cancer Research. ... 465 (1): 119-26. doi:10.1016/j.abb.2007.05.001. PMID 17548047. Oestergaard MZ, Tyrer J, Cebrian A, Shah M, Dunning AM, Ponder ... Zhou J, Damdimopoulos AE, Spyrou G, Brüne B (Mar 2007). "Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on ...
*  Membrane transport protein
Adenine nucleotide translocator (ANT) 2.B: Nonribosomally synthesized porters, such as The Nigericin (Nigericin) Family The ... such as rhodopsin The group translocators provide a special mechanism for the phosphorylation of sugars as they are transported ... ISBN 1-4292-1962-9. p. 119. Cooper, Geoffrey (2009). The Cell: A Molecular Approach. Washington, DC: ASM Press. p. 62. ISBN ... ISBN 1-4292-1962-9. p. 119. Ashley, Ruth. Hann, Gary. Han, Seong S. Cell Biology. New Age International Publishers. ISBN ...
*  Mitochondrial carrier
SLC25A25 adenine nucleotide - SLC25A4, SLC25A5, SLC25A6, SLC25A31 dicarboxylate - SLC25A10 oxoglutarate - SLC25A11 glutamate - ... "Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential". Journal ... nucleotides, amino acids, keto acids and cofactors across the membrane. Such proteins include: ADP/ATP carrier protein (ADP-ATP ... nucleotides, inorganic ions and co-factors through the mitochondrial inner membrane. The transporters consist of six ...
*  Mitochondrial permeability transition pore
Further hypothesis by Halestrap´s group convincingly suggested the MPT was formed by the inner membrane Adenine Nucleotide ... "The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore". Nature. 427 (6973): 461-465. doi ... "The nature of the calcium ion efflux induced in rat liver mitochondria by the oxidation of endogenous nicotinamide nucleotides ... "Regulation of the Inner Membrane Mitochondrial Permeability Transition by the Outer Membrane Translocator Protein (Peripheral ...
Adenine Nucleotide Translocator 1
     Summary Report | CureHunter  Adenine Nucleotide Translocator 1 Summary Report | CureHunter
Adenine Nucleotide Translocator 1: A subtype of mitochondrial ADP, ATP translocase found primarily in heart muscle (MYOCARDIUM ... Adenine Nucleotide Carrier Protein; Adenine Nucleotide Translocator, Muscle Isoform; SLC25A4 Protein; Solute Carrier Family 25( ... Nucleotide Transport Proteins*ATP Translocases Mitochondrial ADP: 95*Adenine Nucleotide Translocator 1: 14 ... Nucleotide Transport Proteins*ATP Translocases Mitochondrial ADP: 95*Adenine Nucleotide Translocator 1: 14 ...
more infohttp://www.curehunter.com/public/keywordSummaryD033741-Adenine-Nucleotide-Translocator-1.do
Anti-Adenine Nucleotide Translocator 2 antibody (ab118125)  Anti-Adenine Nucleotide Translocator 2 antibody (ab118125)
Rabbit polyclonal Adenine Nucleotide Translocator 2 antibody validated for WB, IP and tested in Human. With 2 independent ... Anti-Adenine Nucleotide Translocator 2 antibody. See all Adenine Nucleotide Translocator 2 primary antibodies. ... Immunoprecipitation of Adenine Nucleotide Translocator 2 transfected lysate using ab118125 and Protein A Magnetic Bead, and ... Solute carrier family 25 (mitochondrial carrier adenine nucleotide translocator) member 5 antibody ...
more infohttp://www.abcam.com/adenine-nucleotide-translocator-2-antibody-ab118125.html
Slc25a13 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 ...  Slc25a13 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13 ...
... adenine nucleotide translocator), member 13 (Slc25a13), nuclear gene encoding mitochondrial protein, transcript variant 1, ( ... MC220340 Slc25a13 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member ... Properties for Slc25a13 (untagged) - Mouse solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), ... adenine nucleotide translocator), member 13 (Slc25a13), nuclear gene encoding mitochondrial protein, transcript variant 1, ( ...
more infohttps://www.acris-antibodies.com/cdna/mouse-cdna/slc25a13-untagged-mouse-solute-carrier-family-25-mitochondrial-carrier-adenine-nucleotide-translocator-member-13-slc25a13-nuclear-gene-encoding-mitochondrial-protein-transcript-variant-1-10ug-mc220340.htm
Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) |...  Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) |...
Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT). Sihem ... Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) ... Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) ... Abstract 1295: Mitochondrial Uncoupling in db/db Mouse Hearts is Mediated by the Adenine Nucleotide Translocator (ANT) ...
more infohttp://circ.ahajournals.org/content/114/Suppl_18/II_244.5
Adenine nucleotide translocator synonyms, Adenine nucleotide translocator antonyms - FreeThesaurus.com  Adenine nucleotide translocator synonyms, Adenine nucleotide translocator antonyms - FreeThesaurus.com
Antonyms for Adenine nucleotide translocator. 1 synonym for adenine: A. What are synonyms for Adenine nucleotide translocator? ... Synonyms for Adenine nucleotide translocator in Free Thesaurus. ... Related to Adenine nucleotide translocator: adenine nucleotide ... Adenine nucleotide translocator synonyms, Adenine nucleotide translocator antonyms - FreeThesaurus.com https://www. ... adenine. (redirected from Adenine nucleotide translocator). Also found in: Dictionary, Medical, Acronyms, Encyclopedia, ...
more infohttps://www.freethesaurus.com/Adenine+nucleotide+translocator
Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility...  Short-hairpin RNA-induced suppression of adenine nucleotide translocase-2 in breast cancer cells restores their susceptibility...
Stepien G, Torroni A, Chung AB, Hodge JA, Wallace DC: Differential expression of adenine nucleotide translocator isoforms in ... Adenine nucleotide translocase-2 (ANT2), one of the four adenine nucleotide translocase isoforms expressed in humans, is ... Adenine nucleotide translocase, a protein located in the inner mitochondrial membrane, catalyzes the exchange of mitochondrial ... Jang JY, Jeon YK, Kim CW: Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells ...
more infohttps://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-9-262
Adenine nucleotide translocator 1 | definition of adenine nucleotide translocator 1 by Medical dictionary  Adenine nucleotide translocator 1 | definition of adenine nucleotide translocator 1 by Medical dictionary
What is adenine nucleotide translocator 1? Meaning of adenine nucleotide translocator 1 medical term. What does adenine ... Looking for online definition of adenine nucleotide translocator 1 in the Medical Dictionary? adenine nucleotide translocator 1 ... redirected from adenine nucleotide translocator 1) SLC25A4. A gene on chromosome 4q35 that encodes a mitochondrial solute ... adenine nucleotide translocator 2. *Adenine Nucleotide Translocator Isoform Transcription Pattern. *Adenine Nucleotide ...
more infohttps://medical-dictionary.thefreedictionary.com/adenine+nucleotide+translocator+1
Adenine nucleotide translocator 1 | definition of adenine nucleotide translocator 1 by Medical dictionary  Adenine nucleotide translocator 1 | definition of adenine nucleotide translocator 1 by Medical dictionary
What is adenine nucleotide translocator 1? Meaning of adenine nucleotide translocator 1 medical term. What does adenine ... Looking for online definition of adenine nucleotide translocator 1 in the Medical Dictionary? adenine nucleotide translocator 1 ... redirected from adenine nucleotide translocator 1) SLC25A4. A gene on chromosome 4q35 that encodes a mitochondrial solute ... adenine nucleotide translocator 2. *Adenine Nucleotide Translocator Isoform Transcription Pattern. *Adenine Nucleotide ...
more infohttp://medical-dictionary.thefreedictionary.com/adenine+nucleotide+translocator+1
TGF-β1 induction of the adenine nucleotide translocator 1 in astrocytes occurs through Smads and Sp1 transcription factors |...  TGF-β1 induction of the adenine nucleotide translocator 1 in astrocytes occurs through Smads and Sp1 transcription factors |...
The adenine nucleotide translocator 1 (Ant1) is an inner mitochondrial membrane protein involved with energy mobilization ... The adenine nucleotide translocator 1 (Ant1) is an inner mitochondrial membrane protein involved with energy mobilization ... Buck CR, Jurynec MJ, Gupta DK, Law AK, Bilger J, Wallace DC, McKeon RJ: Increased adenine nucleotide translocator 1 in reactive ... Luciakova K, Hodny Z, Barath P, Nelson BD: In vivo mapping of the human adenine nucleotide translocator-2 (ANT2) promoter ...
more infohttps://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-5-1
Table of Contents - August 04, 2000, 289 (5480) | Science  Table of Contents - August 04, 2000, 289 (5480) | Science
Role of Adenine Nucleotide Translocator 1 in mtDNA Maintenance. By Jyrki Kaukonen, Jukka K. Juselius, Valeria Tiranti, Aija ...
more infohttp://science.sciencemag.org/content/289/5480
Adenine nucleotide translocator - Wikipedia  Adenine nucleotide translocator - Wikipedia
Adenine Nucleotide Translocator 2 at the US National Library of Medicine Medical Subject Headings (MeSH) Adenine Nucleotide ... Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocator, exports ATP from the mitochondrial matrix and ... Adenine Nucleotide Translocator 1 at the US National Library of Medicine Medical Subject Headings (MeSH) ... "Role of adenine nucleotide translocator 1 in mtDNA maintenance". Science. 289 (5480): 782-785. doi:10.1126/science.289.5480.782 ...
more infohttps://en.wikipedia.org/wiki/Adenine_nucleotide_translocator
ADP/ATP translocase 3 (P12236) | InterPro | EMBL-EBI  ADP/ATP translocase 3 (P12236) | InterPro | EMBL-EBI
Adenine nucleotide translocator 1 (IPR002113). Homologous superfamilies. * Homologous superfamily. 1 50 100 150 200 250 298 ...
more infohttp://www.ebi.ac.uk/interpro/protein/P12236
ADP/ATP translocase 2 (P05141) | InterPro | EMBL-EBI  ADP/ATP translocase 2 (P05141) | InterPro | EMBL-EBI
Adenine nucleotide translocator 1 (IPR002113). Homologous superfamilies. * Homologous superfamily. 1 50 100 150 200 250 298 ...
more infohttp://www.ebi.ac.uk/interpro/protein/P05141
Similar articles for PubMed (Select 11756613) - PubMed - NCBI  Similar articles for PubMed (Select 11756613) - PubMed - NCBI
Role of adenine nucleotide translocator 1 in mtDNA maintenance.. Kaukonen J, Juselius JK, Tiranti V, Kyttälä A, Zeviani M, Comi ... A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family. ... Adeno-associated virus-mediated gene transfer of the heart/muscle adenine nucleotide translocator (ANT) in mouse. ... A novel D104G mutation in the adenine nucleotide translocator 1 gene in autosomal dominant progressive external ophthalmoplegia ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?LinkName=pubmed_pubmed&from_uid=11756613
ANT Antibody
		        
	  ANT Antibody
Supplied as 1 mL purified antibody (5 mg/ml) in PBS with 0.09% sodium azide; pH 7.2. ... mitochondrial adenine nucleotide translocator; Slc25a4; solute carrier family 25 (mitochondrial adenine nucleotide translocator ... Protein Aliases: Adenine nucleotide translocator 1; Adenosine translocase; ADP ATP carrier protein 1; ADP ATP translocase; ADP, ... Synthetic peptide, conjugated to KLH, corresponding to residues C G(1) D Q A L S F L K D F(11) of rat Adenosine Nucleotide ...
more infohttps://www.thermofisher.com/antibody/product/Adenosine-Nucleotide-Translocator-1-Antibody-Polyclonal/PA1-85116
TCDB » SEARCH  TCDB » SEARCH
... adenine nucleotide translocator 1 (ANT1); adPEO, Sengers syndrome (SLC25A4) ... Adenine nucleotide transporter, ANT, or ATP:ADP carrier AAC1 (one of three paralogues). Transports heme and heme precursor ... Adenine nucleotide (ATP, ADP) carrier, ANT1; BRITTLE-1. Present in both mitochondria and plastids (Haferkamp and Schmitz-Esser ... The Endoplasmic Reticular Adenine Nucleotide Transporter, ER-ANT1 (probable ATP:ADP exchanger; Leroch et al., 2008) ...
more infohttp://tcdb.org/search/result.php?tc=2.A.29.7
TCDB » SEARCH  TCDB » SEARCH
... adenine nucleotide translocator 1 (ANT1); adPEO, Sengers syndrome (SLC25A4) ... Adenine nucleotide transporter, ANT, or ATP:ADP carrier AAC1 (one of three paralogues). Transports heme and heme precursor ... Adenine nucleotide (ATP, ADP) carrier, ANT1; BRITTLE-1. Present in both mitochondria and plastids (Haferkamp and Schmitz-Esser ... The Endoplasmic Reticular Adenine Nucleotide Transporter, ER-ANT1 (probable ATP:ADP exchanger; Leroch et al., 2008) ...
more infohttp://tcdb.org/search/result.php?tc=2.A.29.23
Oxidative Phosphorylation System: Nuclear Genes and Genetic Disease  Oxidative Phosphorylation System: Nuclear Genes and Genetic Disease
2000) Role of adenine nucleotide translocator 1 in mtDNA maintenance. Science 289 (5480): 782-785. ... Electrons (e−) from carbon oxidations are transferred via NADH (nicotinamide adenine dinucleotide) into OXPHOS complex I, which ... Brain 135 (Pt 1): 12-22.. Ostergaard E, Christensen E, Kristensen E, et al. (2007) Deficiency of the alpha subunit of succinate ... 2008) The Q‐cycle reviewed: how well does a monomeric mechanism of the bc(1) complex account for the function of a dimeric ...
more infohttp://www.els.net/WileyCDA/ElsArticle/refId-a0006029.html
SLC25A4 (Human) Recombinant Protein (P01) - (H00000291-P01) - Products - Abnova  SLC25A4 (Human) Recombinant Protein (P01) - (H00000291-P01) - Products - Abnova
1 a.a. - 298 a.a.) recombinant protein with GST-tag at N-terminal. (H00000291-P01) - Products - Abnova ... solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4. *Omim ID: ... Human SLC25A4 full-length ORF ( NP_001142.2, 1 a.a. - 298 a.a.) recombinant protein with GST-tag at N-terminal. ...
more infohttp://www.abnova.com/products/products_detail.asp?catalog_id=H00000291-P01
SLC25A6P1 Gene - GeneCards | SLC25A6P1 Pseudogene  SLC25A6P1 Gene - GeneCards | SLC25A6P1 Pseudogene
Solute Carrier Family 25 Member 6 Pseudogene 1, including: function, proteins, disorders, pathways, orthologs, and expression. ... Adenine Nucleotide Translocator), Member 6 Pseudogene 3 * Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide ... Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6, Pseudogene 1 2 3 ... The GeneCards human gene database index: 1 2 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC25A6P1
  • it also enhanced the expression and activity of DNA methyltransferase 1 (DNMT1). (biomedcentral.com)
  • SLC25A6P1 (Solute Carrier Family 25 Member 6 Pseudogene 1) is a Pseudogene, and is affiliated with the lncRNA class. (genecards.org)
  • Adenine nucleotide transporter, ANT, or ATP:ADP carrier AAC1 (one of three paralogues). (tcdb.org)
  • 2-oxodicarboxylate carrier 1 (ODC1) transports C5-C7 oxodicarboxylic acid (2-oxoadipate, 2-oxoglularate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate) (functions by a strict antiport mechanism (Palmieri et al. (tcdb.org)
  • ADP/ATP translocases, also known as adenine nucleotide translocases (ANT) and ADP/ATP carrier proteins (AAC), are transporter proteins that enable the exchange of cytosolic adenosine diphosphate (ADP) and mitochondrial adenosine triphosphate (ATP) across the inner mitochondrial membrane. (wikipedia.org)
  • Electrons (e − ) from carbon oxidations are transferred via NADH (nicotinamide adenine dinucleotide) into OXPHOS complex I, which is embedded in the lipid bilayer of the mitochondrial inner membrane (IMM), then transported to coenzyme Q (Q). Some electrons from organic‐acid oxidations are transferred, via other flavin‐containing enzyme complexes directly to CoQ. (els.net)
  • A) Respirometry performed after addition of NADH and Vpr52-96 (1 μM). (nih.gov)
  • Nonsense mutation in pseudouridylate synthase 1 (PUS1) in two brothers affected by myopathy, lactic acidosis and sideroblastic anaemia (MLASA). (giuseppetomasello.it)
  • 2008) The Q‐cycle reviewed: how well does a monomeric mechanism of the bc(1) complex account for the function of a dimeric complex? (els.net)
  • Epigenetic regulation studies have not indi- cated a mechanism of KAI-1 down-regulation . (oktaforex.com)
  • Molecular Ecology:1-35. (uzh.ch)
  • Methods in Molecular Biology, 780(Part 1):57-66. (uzh.ch)
  • 1-3 Both hyperthyroidism and hypothyroidism produce changes in cardiac contractility, myocardial oxygen consumption, cardiac output, blood pressure, and systemic vascular resistance (SVR). (ahajournals.org)
  • Cardiovascular Research, 80(1):20-29. (uzh.ch)
  • Immunofluorescence staining of PC3 cells with MBS7006610 at 1:266,counter-stained with DAPI. (mybiosource.com)
  • At least 1 copy of D4Z4 is required to develop FSHD. (medscape.com)
  • Those without FSHD have approximately 11-100 D4Z4 units, whereas patients with FSHD have 1-10 D4Z4 units. (medscape.com)
  • Figure 1. (els.net)
  • As Figure 8-1 shows, it is executed. (oktaforex.com)
  • To reduce the error from the connecting cable resistance (which can be around 1Ω) the three- and four-wire connections of Figure 4. (oktaforex.com)
  • Journal of Neurological Sciences 62 (1-3): 327-355. (els.net)
  • The Plant Journal, 67(1):145-156. (uzh.ch)
  • Journal of Chromatography B, 854(1-2):173-182. (uzh.ch)