Endosomal Sorting Complexes Required for Transport: A set of protein subcomplexes involved in PROTEIN SORTING of UBIQUITINATED PROTEINS into intraluminal vesicles of MULTIVESICULAR BODIES and in membrane scission during formation of intraluminal vesicles, during the final step of CYTOKINESIS, and during the budding of enveloped viruses. The ESCRT machinery is comprised of the protein products of Class E vacuolar protein sorting genes.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesSignal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Adaptor Proteins, Vesicular Transport: A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.GRB2 Adaptor Protein: A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).Shc Signaling Adaptor Proteins: A family of signaling adaptor proteins that contain SRC HOMOLOGY DOMAINS. Many members of this family are involved in transmitting signals from CELL SURFACE RECEPTORS to MITOGEN-ACTIVATED PROTEIN KINASES.Cytokine Receptor gp130: A cytokine receptor that acts through the formation of oligomeric complexes of itself with a variety of CYTOKINE RECEPTORS.Adaptor Protein Complex 2: An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.Protein-Tyrosine Kinases: Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Phosphotyrosine: An amino acid that occurs in endogenous proteins. Tyrosine phosphorylation and dephosphorylation plays a role in cellular signal transduction and possibly in cell growth control and carcinogenesis.Amaranth Dye: A sulfonic acid-based naphthylazo dye used as a coloring agent for foodstuffs and medicines and as a dye and chemical indicator. It was banned by the FDA in 1976 for use in foods, drugs, and cosmetics. (From Merck Index, 11th ed)Carboxylic Ester Hydrolases: Enzymes which catalyze the hydrolysis of carboxylic acid esters with the formation of an alcohol and a carboxylic acid anion.Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)Caenorhabditis elegans Proteins: Proteins from the nematode species CAENORHABDITIS ELEGANS. The proteins from this species are the subject of scientific interest in the area of multicellular organism MORPHOGENESIS.Caenorhabditis elegans: A species of nematode that is widely used in biological, biochemical, and genetic studies.Aedes: A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.Butterflies: Slender-bodies diurnal insects having large, broad wings often strikingly colored and patterned.Allosteric Regulation: The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.EstersSterol Esterase: An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.Lymphoma, B-Cell, Marginal Zone: Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.Helicobacter pylori: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.Stomach Neoplasms: Tumors or cancer of the STOMACH.Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.Helicobacter heilmannii: A species of gram-negative, spiral-shaped bacteria found in the gastric mucosa that is associated with chronic antral gastritis. This bacterium was first discovered in samples removed at endoscopy from patients investigated for HELICOBACTER PYLORI colonization.Gastritis: Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.2-Pyridinylmethylsulfinylbenzimidazoles: Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.Helicobacter: A genus of gram-negative, spiral-shaped bacteria that has been isolated from the intestinal tract of mammals, including humans. It has been associated with PEPTIC ULCER.Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Wheat Germ Agglutinins: Lectins purified from the germinating seeds of common wheat (Triticum vulgare); these bind to certain carbohydrate moieties on cell surface glycoproteins and are used to identify certain cell populations and inhibit or promote some immunological or physiological activities. There are at least two isoforms of this lectin.Recombinant Proteins: Proteins prepared by recombinant DNA technology.PeroxidasesTriticum: A plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS.Splanchnic Nerves: The major nerves supplying sympathetic innervation to the abdomen. The greater, lesser, and lowest (or smallest) splanchnic nerves are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses. The lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Lipid Peroxides: Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.Mast Cells: Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.Immunoglobulin E: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).Rutaceae: A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.Anaphylaxis: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.Leukemia, Basophilic, Acute: A rare acute myeloid leukemia in which the primary differentiation is to BASOPHILS. It is characterized by an extreme increase of immature basophilic granulated cells in the bone marrow and blood. Mature basophils are usually sparse.Cell Degranulation: The process of losing secretory granules (SECRETORY VESICLES). This occurs, for example, in mast cells, basophils, neutrophils, eosinophils, and platelets when secretory products are released from the granules by EXOCYTOSIS.Basophils: Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.Receptors, IgE: Specific molecular sites on the surface of B- and T-lymphocytes which combine with IgEs. Two subclasses exist: low affinity receptors (Fc epsilon RII) and high affinity receptors (Fc epsilon RI).Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Passive Cutaneous Anaphylaxis: An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.
(1/12958) Endocytosis: EH domains lend a hand.

A number of proteins that have been implicated in endocytosis feature a conserved protein-interaction module known as an EH domain. The three-dimensional structure of an EH domain has recently been solved, and is likely to presage significant advances in understanding molecular mechanisms of endocytosis.  (+info)

(2/12958) The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors.

BACKGROUND: The adaptor protein Gads is a Grb2-related protein originally identified on the basis of its interaction with the tyrosine-phosphorylated form of the docking protein Shc. Gads protein expression is restricted to hematopoietic tissues and cell lines. Gads contains a Src homology 2 (SH2) domain, which has previously been shown to have a similar binding specificity to that of Grb2. Gads also possesses two SH3 domains, but these have a distinct binding specificity to those of Grb2, as Gads does not bind to known Grb2 SH3 domain targets. Here, we investigated whether Gads is involved in T-cell signaling. RESULTS: We found that Gads is highly expressed in T cells and that the SLP-76 adaptor protein is a major Gads-associated protein in vivo. The constitutive interaction between Gads and SLP-76 was mediated by the carboxy-terminal SH3 domain of Gads and a 20 amino-acid proline-rich region in SLP-76. Gads also coimmunoprecipitated the tyrosine-phosphorylated form of the linker for activated T cells (LAT) adaptor protein following cross-linking of the T-cell receptor; this interaction was mediated by the Gads SH2 domain. Overexpression of Gads and SLP-76 resulted in a synergistic augmentation of T-cell signaling, as measured by activation of nuclear factor of activated T cells (NFAT), and this cooperation required a functional Gads SH2 domain. CONCLUSIONS: These results demonstrate that Gads plays an important role in T-cell signaling via its association with SLP-76 and LAT. Gads may promote cross-talk between the LAT and SLP-76 signaling complexes, thereby coupling membrane-proximal events to downstream signaling pathways.  (+info)

(3/12958) Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome.

The vacuolar protein sorting (VPS) pathway of Saccharomyces cerevisiae mediates transport of vacuolar protein precursors from the late Golgi to the lysosome-like vacuole. Sorting of some vacuolar proteins occurs via a prevacuolar endosomal compartment and mutations in a subset of VPS genes (the class D VPS genes) interfere with the Golgi-to-endosome transport step. Several of the encoded proteins, including Pep12p/Vps6p (an endosomal target (t) SNARE) and Vps45p (a Sec1p homologue), bind each other directly [1]. Another of these proteins, Vac1p/Pep7p/Vps19p, associates with Pep12p and binds phosphatidylinositol 3-phosphate (PI(3)P), the product of the Vps34 phosphatidylinositol 3-kinase (PI 3-kinase) [1] [2]. Here, we demonstrate that Vac1p genetically and physically interacts with the activated, GTP-bound form of Vps21p, a Rab GTPase that functions in Golgi-to-endosome transport, and with Vps45p. These results implicate Vac1p as an effector of Vps21p and as a novel Sec1p-family-binding protein. We suggest that Vac1p functions as a multivalent adaptor protein that ensures the high fidelity of vesicle docking and fusion by integrating both phosphoinositide (Vps34p) and GTPase (Vps21p) signals, which are essential for Pep12p- and Vps45p-dependent targeting of Golgi-derived vesicles to the prevacuolar endosome.  (+info)

(4/12958) Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis.

The Met tyrosine kinase - the HGF receptor - induces cell transformation and metastasis when constitutively activated. Met signaling is mediated by phosphorylation of two carboxy-terminal tyrosines which act as docking sites for a number of SH2-containing molecules. These include Grb2 and p85 which couple the receptor, respectively, with Ras and PI 3-kinase. We previously showed that a Met mutant designed to obtain preferential coupling with Grb2 (Met2xGrb2) is permissive for motility, increases transformation, but - surprisingly - is impaired in causing invasion and metastasis. In this work we used Met mutants optimized for binding either p85 alone (Met2xPI3K) or p85 and Grb2 (MetPI3K/Grb2) to evaluate the relative importance of Ras and PI 3-kinase as downstream effectors of Met. Met2xPI3K was competent in eliciting motility, but not transformation, invasion, or metastasis. Conversely, MetP13K/Grb2 induced motility, transformation, invasion and metastasis as efficiently as wild type Met. Furthermore, the expression of constitutively active PI 3-kinase in cells transformed by the Met2xGrb2 mutant, fully rescued their ability to invade and metastasize. These data point to a central role for PI 3-kinase in Met-mediated invasiveness, and indicate that simultaneous activation of Ras and PI 3-kinase is required to unleash the Met metastatic potential.  (+info)

(5/12958) Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.

Cbl-b, a mammalian homolog of Cbl, consists of an N-terminal region (Cbl-b-N) highly homologous to oncogenic v-Cbl, a Ring finger, and a C-terminal region containing multiple proline-rich stretches and potential tyrosine phosphorylation sites. In the present study, we demonstrate that upon engagement of the T cell receptor (TCR), endogenous Cbl-b becomes rapidly tyrosine-phosphorylated. In heterogeneous COS-1 cells, Cbl-b was phosphorylated on tyrosine residues by both Syk- (Syk/Zap-70) and Src- (Fyn/Lck) family kinases, with Syk kinase inducing the most prominent effect. Syk associates and phosphorylates Cbl-b in Jurkat T cells. A Tyr-316 Cbl-binding site in Syk was required for the association with and for the maximal tyrosine phosphorylation of Cbl-b. Mutation at a loss-of-function site (Gly-298) in Cbl-b-N disrupts its interaction with Syk. Cbl-b constitutively binds Grb2 and becomes associated with Crk-L upon TCR stimulation. The Grb2- and the Crk-L-binding regions were mapped to the C-terminus of Cbl-b. The Crk-L-binding sites were further determined to be Y655DVP and Y709KIP, with the latter being the primary binding site. Taken together, these results implicate that Cbl-b is involved in TCR-mediated intracellular signaling pathways.  (+info)

(6/12958) Polarized distribution of Bcr-Abl in migrating myeloid cells and co-localization of Bcr-Abl and its target proteins.

Bcr-Abl plays a critical role in the pathogenesis of Philadelphia chromosome-positive leukemia. Although a large number of substrates and interacting proteins of Bcr-Abl have been identified, it remains unclear whether Bcr-Abl assembles multi-protein complexes and if it does where these complexes are within cells. We have investigated the localization of Bcr-Abl in 32D myeloid cells attached to the extracellular matrix. We have found that Bcr-Abl displays a polarized distribution, colocalizing with a subset of filamentous actin at trailing portions of migrating 32D cells, and localizes on the cortical F-actin and on vesicle-like structures in resting 32D cells. Deletion of the actin binding domain of Bcr-Abl (Bcr-AbI-AD) dramatically enhances the localization of Bcr-Abl on the vesicle-like structures. These distinct localization patterns of Bcr-Abl and Bcr-Abl-AD enabled us to examine the localization of Bcr-Abl substrate and interacting proteins in relation to Bcr-Abl. We found that a subset of biochemically defined target proteins of Bcr-Abl redistributed and co-localized with Bcr-Abl on F-actin and on vesicle-like structures. The co-localization of signaling proteins with Bcr-Abl at its sites of localization supports the idea that Bcr-Abl forms a multi-protein signaling complex, while the polarized distribution and vesicle-like localization of Bcr-Abl may play a role in leukemogenesis.  (+info)

(7/12958) Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells.

Increased breast cancer growth has been associated with increased expression of epidermal growth factor receptor (EGFR) and ErbB2 receptor tyrosine kinases (RTKs). Upon activation, RTKs may transmit their oncogenic signals by binding to the growth factor receptor bound protein-2 (Grb2), which in turn binds to SOS and activates the Ras/Raf/MEK/mitogen-activated protein (MAP) kinase pathway. Grb2 is important for the transformation of fibroblasts by EGFR and ErbB2; however, whether Grb2 is also important for the proliferation of breast cancer cells expressing these RTKs is unclear. We have used liposomes to deliver nuclease-resistant antisense oligodeoxynucleotides (oligos) specific for the GRB2 mRNA to breast cancer cells. Grb2 protein downregulation could inhibit breast cancer cell growth; the degree of growth inhibition was dependent upon the activation and/or endogenous levels of the RTKs. Grb2 inhibition led to MAP kinase inactivation in EGFR, but not in ErbB2, breast cancer cells, suggesting that different pathways might be used by EGFR and ErbB2 to regulate breast cancer growth.  (+info)

(8/12958) Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.

We have identified Socs1 as a downstream component of the Kit receptor tyrosine kinase signalling pathway. We show that the expression of Socs1 mRNA is rapidly increased in primary bone marrow-derived mast cells following exposure to Steel factor, and Socs1 inducibly binds to the Kit receptor tyrosine kinase via its Src homology 2 (SH2) domain. Previous studies have shown that Socs1 suppresses cytokine-mediated differentiation in M1 cells inhibiting Janus family kinases. In contrast, constitutive expression of Socs1 suppresses the mitogenic potential of Kit while maintaining Steel factor-dependent cell survival signals. Unlike Janus kinases, Socs1 does not inhibit the catalytic activity of the Kit tyrosine kinase. In order to define the mechanism by which Socs1-mediated suppression of Kit-dependent mitogenesis occurs, we demonstrate that Socs1 binds to the signalling proteins Grb-2 and the Rho-family guanine nucleotide exchange factors Vav. We show that Grb2 binds Socs1 via its SH3 domains to putative diproline determinants located in the N-terminus of Socs1, and Socs1 binds to the N-terminal regulatory region of Vav. These data suggest that Socs1 is an inducible switch which modulates proliferative signals in favour of cell survival signals and functions as an adaptor protein in receptor tyrosine kinase signalling pathways.  (+info)

*  Signal transducing adaptor protein
Signal transducing adaptor proteins are proteins that are accessory to main proteins in a signal transduction pathway. Adaptor ... phosphoinositide-3-kinase adaptor protein 1 SH2B1 - SH2B adaptor protein 1 SH2B2 - SH2B adaptor protein 2 SH2B3 - SH2B adaptor ... adaptor proteins.2C vesicular transport Signal Transducing Adaptor Proteins at the US National Library of Medicine Medical ... GRB2-related adaptor protein GRAP2 - GRB2-related adaptor protein 2 LDLRAP1 - low-density lipoprotein receptor adaptor protein ...
*  STAP2
Signal-transducing adaptor protein 2 is a protein that in humans is encoded by the STAP2 gene. This gene encodes the substrate ... 2007). "Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal ... "Entrez Gene: STAP2 signal-transducing adaptor protein-2". Rosenzweig BL, Imamura T, Okadome T, et al. (1995). "Cloning and ... 2003). "Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells ...
*  STAP1
Signal-transducing adaptor protein 1 is a protein that in humans is encoded by the STAP1 gene. The protein encoded by this gene ... A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart. STAP1 has been shown to interact ... functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is ... an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif". J. Biol. Chem. 278 (13 ...
*  Lymphocyte cytosolic protein 2
SLP-76 signal Transducing adaptor proteins at the US National Library of Medicine Medical Subject Headings (MeSH). ... is a gene that encodes a signal-transducing adaptor protein. No full structure for SLP-76 has been solved. The PDB file 1H3H ... "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors ... "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors ...
*  Signal transducing adaptor molecule
Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene. This gene was identified by the ... has been found to bind and counteract the function of this protein. Signal transducing adaptor molecule has been shown to ... suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2". The Journal of Biological Chemistry ... signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc ...
*  Adaptor protein
... may refer to: Signal transducing adaptor protein Vesicular transport adaptor protein Clathrin adaptor protein, ...
*  STAM2
Signal transducing adapter molecule 2 is a protein that in humans is encoded by the STAM2 gene. The protein encoded by this ... "Entrez Gene: STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2". Rual JF, Venkatesan K, Hao T, Hirozane- ... an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the ... "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain ...
*  MAPK/ERK pathway
Janus kinase Phosphatase Signal transducing adaptor protein G protein-coupled receptor Orton RJ, Sturm OE, Vyshemirsky V, ... Protein microarray analysis can be used to detect subtle changes in protein activity in signaling pathways. The developmental ... "extracellular signal-regulated kinases" (ERKs) and "microtubule associated protein kinase" (MAPK). One of the first proteins ... phosphorylates ribosomal protein S6. Mitogen-activated protein kinases that phosphorylate ribosomal protein S6 were the first ...
*  MADD (gene)
The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a ... Nakayama M, Kikuno R, Ohara O (2003). "Protein-Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a ... adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK ... MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the MADD gene. Tumor necrosis factor alpha ...
*  NCK1
It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to ... Signal transducing adaptor protein Receptor tyrosine kinase Ras superfamily GRCh38: Ensembl release 89: ENSG00000158092 - ... The Nck (non-catalytic region of tyrosine kinase adaptor protein 1) belongs to the adaptor family of proteins. The nck gene was ... "Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity". Cell. Signal. 23 (10): 1651 ...
*  Adapter (disambiguation)
Adapter pattern, a software design pattern used for computer programming Signal transducing adaptor protein, a type of protein ... Adapter may refer to: Adapter (device), used to match the physical or electrical characteristics of two different objects AC ... adapter, an electric power supply device Adapter (genetics), a small DNA molecule used in genetic engineering Adapter (rocketry ... a segment between rocket stages Adapter (computing), used to connect various hardware devices Adapter (piping), a short length ...
*  SH3 domain
Signal transducing adaptor proteins CDC24 Cdc25 PI3 kinase Phospholipase Ras GTPase-activating protein Vav proto-oncogene GRB2 ... The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases SH3 proteins usually ... SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein, and the Src kinase and ... In addition to that, the SH3 domain was responsible for controlling protein-protein interactions in the signal transduction ...
*  STAP
... a signal-transducing adaptor protein encoded by the STAP1 gene STAP2, a signal-transducing adaptor protein encoded by the STAP2 ... STAP, or stap, may refer to: List of people with the surname Stap Space-time adaptive processing, a signal processing technique ...
*  TIMM8A
Deafness-dystonia peptide Deafness-dystonia protein TIMM8A has been shown to interact with Signal transducing adaptor molecule ... "Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1". Biochem. Biophys ... "Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1". Biochem. Biophys ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. England. 3 (1): 89. doi: ...
*  CD27
This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been ... CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the ... The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long ... Yamamoto H, Kishimoto T, Minamoto S (Nov 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated ...
*  STAMBP
The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role ... One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. ... STAM-binding protein is a protein that in humans is encoded by the STAMBP gene. Cytokine-mediated signal transduction in the ... Signal transducing adaptor molecule and GRAP2. GRCm38: Ensembl release 89: ENSMUSG00000006906 - Ensembl, May 2017 "Human PubMed ...
*  Apoptosis
... or directly transducing the signal via adaptor proteins to the apoptotic mechanisms. An extrinsic pathway for initiation ... The adenovirus E1B-55K protein and the hepatitis B virus HBx protein are examples of viral proteins that can perform such a ... Examples of viral Bcl-2 proteins include the Epstein-Barr virus BHRF1 protein and the adenovirus E1B 19K protein. Some viruses ... apoptotic signals must cause regulatory proteins to initiate the apoptosis pathway. This step allows those signals to cause ...
*  List of MeSH codes (D12.644)
... adaptor proteins, signal transducing MeSH D12.644.360.024.264 --- caveolin 1 MeSH D12.644.360.024.272 --- caveolin 2 MeSH ... grb2 adaptor protein MeSH D12.644.360.024.298 --- grb7 adaptor protein MeSH D12.644.360.024.300 --- grb10 adaptor protein MeSH ... rap gtp-binding proteins MeSH D12.644.360.525.475.100 --- rap1 gtp-binding proteins MeSH D12.644.360.525.500 --- ras proteins ... 14-3-3 proteins MeSH D12.644.360.024.318 --- proto-oncogene proteins c-crk MeSH D12.644.360.024.326 --- proto-oncogene proteins ...
*  NKG2D
DAP10 functions as an adaptor protein and transduces the signal after the ligand binding by recruiting the p85 subunit of PI3K ... DAP12 bears ITAM motif and activates protein tyrosine kinases Syk and Zap70 signalling. NKG2D ligands are induced-self proteins ... By contrast, NKG2D-S associates with two adaptor proteins: DAP10 and DAP12. DAP10 recruits the p85 subunit of PI3K and a ... "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D". Nature Immunology ...
*  Death receptor 4
2002). "Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL- ... Miyazaki, T; Reed J C (June 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat ... and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death ... Miyazaki T, Reed JC (2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. ...
*  SH2 domain
... s are commonly found in adaptor proteins that aid in the signal transduction of receptor tyrosine kinase pathways. ... conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins. SH2 ... Phosphorylation of tyrosine residues in a protein occurs during signal transduction and is carried out by tyrosine kinases. In ... Koytiger G; Kaushansky A; Gordus A; Rush J; Sorger PK; Macbeath G (January 2013). "Phosphotyrosine signaling proteins that ...
*  Death receptor 5
... a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. DR5 has been shown to ... and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the ... a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL". Current Biology. 7 (9): 693-6. doi: ... The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This ...
*  Synaptic pruning
Reverse signaling between ephrin-B proteins and their Eph receptor tyrosine kinases have been found to initiate the retraction ... Ensuing binding of Ephrin-B3 to the cytoplasmic adaptor protein, Grb4, leads to the recruitment and binding of Dock180 and p21 ... Ephrin-B3 is observed to transduce tyrosine phosphorylation-dependent reverse signals into hippocampal axons that trigger ... Forward signaling between Ephrin-A and EphA, along the anterior-posterior axis, has been found to inhibit retinal axon branch ...
*  Interleukin-1 receptor family
The signal is transduced by cytoplasmatic kinases (such as IRAKs) and by other adaptors, such as tumor necrosis factor 6 (TRAF6 ... cytosolic adaptor proteins (such as MyD88 adaptor protein) and insect and nematode Toll. Each of these groups is involved ... When the receptor is activated TIR domain recruits downstream cytoplasmic signalization adaptor proteins (such as Myd88 adaptor ... May 2000). "IL-1 Signaling Cascade in Liver Cells and the Involvement of a Soluble Form of the IL-1 Receptor Accessory Protein ...
*  Co-receptor
They can also transmit signals through adaptor molecules through their cytoplasmic domain which bind to signalling motifs. ... First, cell surface receptors can directly transduce signals by possessing both serine and threonine or simply serine in the ... Co-receptors are proteins that maintain a three-dimensional structure. The large extracellular domains make up approximately 76 ... Secondly, certain surface receptors lacking a cytoplasmic domain can transduce signals through ligand binding. Once the surface ...
*  Pattern recognition receptor
NODs transduce signals in the pathway of NF-κB and MAP kinases via the serine-threonine kinase called RIP2. NODs signal via N- ... Interaction with other proteins (e.g. the adaptor molecule ASC) is mediated via N-terminal pyrin (PYD) domain. There are 14 ... BDCA2 signaling via ITAM and signaling through ITIM belong among the TLR-dependent signaling. TLR-independent signaling such as ... Among other proteins the most important are: the MHC Class II transactivator (CIITA), IPAF, BIRC1 etc. Some of these proteins ...
Signal transducing adaptor protein - Wikipedia  Signal transducing adaptor protein - Wikipedia
Signal transducing adaptor proteins are proteins that are accessory to main proteins in a signal transduction pathway. Adaptor ... phosphoinositide-3-kinase adaptor protein 1 SH2B1 - SH2B adaptor protein 1 SH2B2 - SH2B adaptor protein 2 SH2B3 - SH2B adaptor ... adaptor proteins.2C vesicular transport Signal Transducing Adaptor Proteins at the US National Library of Medicine Medical ... GRB2-related adaptor protein GRAP2 - GRB2-related adaptor protein 2 LDLRAP1 - low-density lipoprotein receptor adaptor protein ...
more infohttps://en.wikipedia.org/wiki/Signal_transducing_adaptor_protein
Signal Transducing Adaptor Proteins
     Summary Report | CureHunter  Signal Transducing Adaptor Proteins Summary Report | CureHunter
Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing ... A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, ... each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. ... Signal Transducing Adaptor Proteins. Subscribe to New Research on Signal Transducing Adaptor Proteins ...
more infohttp://www.curehunter.com/public/keywordSummaryD048868-Signal-Transducing-Adaptor-Proteins.do
Browsing  by Subject Adaptor Proteins, Signal Transducing  Browsing by Subject "Adaptor Proteins, Signal Transducing"
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.  Hawes, BE; Lefkowitz, Robert J; Touhara, K; ... Browsing by Subject "Adaptor Proteins, Signal Transducing". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U ... Such motifs in other proteins are known to mediate protein-protein interactions ... ... One aspect of the function of the beta-arrestins is to serve as scaffold or adapter molecules coupling G-protein coupled ...
more infohttps://dukespace.lib.duke.edu/dspace/browse?type=subject&value=Adaptor%20Proteins%2C%20Signal%20Transducing
stap1 Protein, signal transducing adaptor family member 1 - Creative BioMart  stap1 Protein, signal transducing adaptor family member 1 - Creative BioMart
The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec ... by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. ... docking protein BRDG1; stem cell adaptor protein 1; BCR downstream-signaling protein 1; signal-transducing adaptor protein- ... STAP1; signal transducing adaptor family member 1; signal-transducing adaptor protein 1; BCR downstream signaling 1; BRDG1; ...
more infohttps://www.creativebiomart.net/symbolsearch_Stap1.htm
Stam2 - Signal transducing adapter molecule 2 - Mus musculus (Mouse) - Stam2 gene & protein  Stam2 - Signal transducing adapter molecule 2 - Mus musculus (Mouse) - Stam2 gene & protein
Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role ... Involved in intracellular signal transduction mediated by cytokines and growth factors. ... Protein. Similar proteins. Species. Score. Length. Source. O88811. Signal transducing adaptor molecule (SH3 domain and ITAM ... Protein. Similar proteins. Species. Score. Length. Source. O88811. Signal transducing adaptor molecule (SH3 domain and ITAM ...
more infohttps://www.uniprot.org/uniprot/O88811
Signal-transducing adaptor protein 2  Signal-transducing adaptor protein 2
Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells.. ... Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.. ... The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl.. ... The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that ...
more infohttps://pharos.nih.gov/idg/targets/Q9UGK3
Genome-wide organization, evolutionary diversification of the COMMD family genes of amphioxus (Branchiostoma belcheri) with the...  Genome-wide organization, evolutionary diversification of the COMMD family genes of amphioxus (Branchiostoma belcheri) with the...
Adaptor Proteins, Signal Transducing/genetics*. *Adaptor Proteins, Signal Transducing/immunology*. *Adaptor Proteins, Signal ... and all AmphiCOMMD proteins contain the conserved COMM domain with two NES (Nuclear Export Signal) motifs. Secondly, the ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/29551666
Center for Theoretical & Mathematical Sciences   » People  Center for Theoretical & Mathematical Sciences » People
Adaptor Proteins, Signal Transducing • Adenosine • Adolescent • Adult • Aedes • Aging • Algorithms • Alleles • Allosteric ... Protein Binding • Proteins • Proto-Oncogene Proteins • Pupa • Pyrrolidonecarboxylic Acid • Quantitative Trait Loci • ... Carrier Proteins • Case-Control Studies • Cautery • cdc42 GTP-Binding Protein, Saccharomyces cerevisiae • Cell Count • Cell ... Wheeler, DE; Nijhout, HF, A perspective for understanding the modes of juvenile hormone action as a lipid signaling system., ...
more infohttp://fds.duke.edu/db/aas/math/ctms/faculty/hfn
High incidence of t(11;18)(q21;q21) in Helicobacter pylori-negative gastric MALT lymphoma.  High incidence of t(11;18)(q21;q21) in Helicobacter pylori-negative gastric MALT lymphoma.
0/Adaptor Proteins, Signal Transducing; 0/BCL10 protein, human; 0/Carrier Proteins ... Adaptor Proteins, Signal Transducing*. Adult. Aged. Carrier Proteins / analysis. Cell Nucleus / chemistry. Chromosomes, Human, ...
more infohttp://www.biomedsearch.com/nih/High-incidence-in-Helicobacter-pylori/12517817.html
Endometrial Cancer | Cancer Genetics Web  Endometrial Cancer | Cancer Genetics Web
Signal Transducing Adaptor Proteins. *PTEN. *Case-Control Studies. *Gene Expression Profiling. *HtrA1 ... Western blot further showed that PCDH10 restoration activate apoptotic signaling pathway via caspase signaling in both EEC cell ... Mutated Genes and Abnormal Protein Expression. Latest Publications. Found this page useful? ... Mutated Genes and Abnormal Protein Expression (38). Clicking on the Gene or Topic will take you to a separate more detailed ...
more infohttp://www.cancerindex.org/geneweb/X1005.htm
Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing...  Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing...
... protein, a necessary component of DNA mismatch repair (MMR), in G2-M cell cycle checkpoint arrest after 6-thioguanine (6-TG) ... 0/Adaptor Proteins, Signal Transducing; 0/Carrier Proteins; 0/MLH1 protein, human; 0/Mlh1 protein, mouse; 0/Neoplasm Proteins; ... Adaptor Proteins, Signal Transducing. Animals. Carrier Proteins. Cell Cycle / radiation effects*. Cell Survival. Cells, ... Nuclear Proteins. Thioguanine / pharmacology. Tumor Cells, Cultured. Tumor Suppressor Protein p53 / physiology. ...
more infohttp://www.biomedsearch.com/nih/Defective-expression-DNA-mismatch-repair/9485033.html
SFRP2 | Cancer Genetics Web  SFRP2 | Cancer Genetics Web
p53 Protein. *Signal Transducing Adaptor Proteins. *Adenoma. *Chromosome 4. *Stomach Cancer. *CpG Islands ... What pathways are this gene/protein implicaed in?. Show (1). SFRP2 is involved in:. - Wnt signaling pathway KEGG. Data from ... Wnt receptor signaling pathway involved in somitogenesis - Wnt-activated receptor activity - Wnt-protein binding Data from Gene ... Secreted frizzled related protein 2 (SFRP2), APC1A in WNT signaling pathway and the DNA repair gene, O6-methylguanine-DNA ...
more infohttp://www.cancerindex.org/geneweb/SFRP2.htm
Recombinant Human STAP2 protein (ab163151) | Abcam  Recombinant Human STAP2 protein (ab163151) | Abcam
Ab163151 is a protein fragment produced in Wheat germ and has been validated in WB, ELISA. Abcam provides free… ... Signal transducing adaptor protein 2. *Signal-transducing adaptor protein 2. *Ssignal transducing adaptor family member 2 ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ... Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may ...
more infohttp://www.abcam.com/recombinant-human-stap2-protein-ab163151.html
MEDLINE - Results of the search |page  1|
	  MEDLINE - Results of the search |page 1|
0 (Adaptor Proteins, Signal Transducing); 0 (Lat protein, rat); 0 (Membrane Proteins); 0 (Phosphoproteins); 0 (Plant Extracts ... Adaptor Proteins, Signal Transducing/metabolism. Immunoglobulin E/physiology. Mast Cells/drug effects. Mast Cells/metabolism. ... The protein lysates were analysed by using Western Blot to determine the effect of tHGA on various important signalling ... Membrane Proteins/metabolism. Phosphoproteins/metabolism. Plant Extracts/pharmacology. Rutaceae. [Mh] MeSH terms secundary:. ...
more infohttp://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&base=MEDLINE&lang=i&nextAction=lnk&isisFrom=1&count=10&exprSearch=rutaceae
STAP2 - Wikipedia  STAP2 - Wikipedia
Signal-transducing adaptor protein 2 is a protein that in humans is encoded by the STAP2 gene. This gene encodes the substrate ... 2007). "Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal ... "Entrez Gene: STAP2 signal-transducing adaptor protein-2". Rosenzweig BL, Imamura T, Okadome T, et al. (1995). "Cloning and ... 2003). "Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells ...
more infohttps://en.wikipedia.org/wiki/STAP2
Western blot analysis of GEM fractions. After stimulati | Open-i  Western blot analysis of GEM fractions. After stimulati | Open-i
Adaptor Proteins, Signal Transducing*. *B-Lymphocytes/immunology*. *Carrier Proteins/immunology/metabolism*. *Cell Membrane/ ... B cell linker protein (BLNK) and Src homology 2 domain-containing leukocyte protein of 76 kD (SLP-76) are adaptor proteins ... B cell linker protein (BLNK) and Src homology 2 domain-containing leukocyte protein of 76 kD (SLP-76) are adaptor proteins ... Moreover, we demonstrate that addition of both linker for activation of T cells (LAT) and Grb2-related adaptor downstream of ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2193288_JEM000815.f2&req=4
A) TCR-LAT assembly formation requires palmitoylation  | Open-i  A) TCR-LAT assembly formation requires palmitoylation | Open-i
Adaptor Proteins, Signal Transducing*. *Carrier Proteins/isolation & purification*. *Membrane Microdomains*. *Membrane Proteins ... Many downstream signaling proteins coisolated with the TCR/LAT-enriched plasma membrane fragments, suggesting that LAT/TCR ... Many downstream signaling proteins coisolated with the TCR/LAT-enriched plasma membrane fragments, suggesting that LAT/TCR ... Here, we studied the assembly of TCR with signal transduction proteins and raft markers in plasma membrane subdomains of Jurkat ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2192654_JCB0003036.f5a&req=4
DaDaBIK database front-end - dadabik.com  DaDaBIK database front-end - dadabik.com
Subject headings: Acetylcholine/*metabolism; Adaptor Proteins, Signal Transducing; Animals; Arcuate Nucleus of Hypothalamus/ ... Proteins/*genetics; Synaptophysin/metabolism; Vesicular Acetylcholine Transport Proteins; *Vesicular Transport Proteins; gamma- ... Description: Tubby and tubby-like proteins (TULPs) are encoded by members of a small gene family. An autosomal recessive ... Membrane Transport Proteins; Mice; Mutation; Obesity/*physiopathology; Polymerase Chain Reaction; Presynaptic Terminals/ ...
more infohttps://www.strategian.com/dadabik9/index.php?tablename=refs&function=search&where_clause=&order=author&order_type=ASC&page=9
Go to Alternative antigen receptor (TCR) signaling in T cells derived from ZAP-70-deficient patients expressing high levels of...  Go to Alternative antigen receptor (TCR) signaling in T cells derived from ZAP-70-deficient patients expressing high levels of...
Intracellular Signaling Peptides and Proteins; Jurkat Cells; Carrier Proteins/metabolism; *Adaptor Proteins, Signal Transducing ... Thus, ZAP-70 and Syk appear to play distinct roles in transducing a TCR-mediated signal. ... Signal Transduction/genetics; Cell Division; Interleukin-2/secretion; ZAP-70 Protein-Tyrosine Kinase; ... JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases/metabolism; Phospholipase C gamma; Phosphotyrosine/ ...
more infohttp://www.igmm.cnrs.fr/en/publication/alternative-antigen-receptor-tcr-signaling-in-t-cells-derived-from-zap-70-deficient-patients-expressing-high-levels-of-syk/
  • Our results indicate that TCR signaling assemblies in plasma membrane subdomains, rather than generally concentrating raft-associated membrane proteins and lipids, form by a selective protein-mediated anchoring of the raft membrane protein LAT in vicinity of TCR. (nih.gov)
  • These results suggest that STAP-2 acts as an endogenous negative regulator of Epstein-Barr virus LMP1-mediated signaling through TRAF3 and TRADD. (nih.gov)
  • The protein content of an adaptor protein, STAP-2 is controlled by E3 ubiquitin ligase Cbl. (nih.gov)
  • Using an antiserum to the vesicular acetylcholine transporter (VAChT), a marker for cholinergic neurons, many unusually large VAChT-immunoreactive (-ir) nerve terminals, identified by colocalization with the synaptic vesicle protein synaptophysin, were demonstrated in the hypothalamic arcuate nucleus of obese tub/tub mice. (strategian.com)
  • SH2 domains recognise specific amino acid sequences within proteins containing phosphotyrosine residues and SH3 domains recognise proline-rich sequences within specific peptide sequence contexts of proteins. (wikipedia.org)
  • Here, we report that epithelial cell proliferation in the developing zebrafish intestine is stimulated both by the presence of the resident microbiota and by activation of Wnt signaling. (zfin.org)
  • Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation. (biomedsearch.com)
  • A role for the Mut L homologue-1 (MLH1) protein, a necessary component of DNA mismatch repair (MMR), in G2-M cell cycle checkpoint arrest after 6-thioguanine (6-TG) exposure was suggested previously. (biomedsearch.com)
  • We also show that human MLH1 and MSH2 steady-state protein levels did not vary with damage or cell cycle changes caused by IR or 6-TG. (biomedsearch.com)
  • This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. (cancerindex.org)
  • Firstly, we clone the full length of AmphiCOMMDs, and all AmphiCOMMD proteins contain the conserved COMM domain with two NES (Nuclear Export Signal) motifs. (nih.gov)